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Search of human proteins with 62243567
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62243567 netrin receptor Unc5h1 [Homo sapiens]
(842 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62243567 netrin receptor Unc5h1 [Homo sapiens] 1724 0.0
gi|16933525 unc5C [Homo sapiens] 906 0.0
gi|32261318 unc-5 homolog B [Homo sapiens] 831 0.0
gi|209977117 unc-5 homolog D [Homo sapiens] 645 0.0
gi|27734865 unc-5 homolog C-like [Homo sapiens] 100 1e-20
gi|118572606 hemicentin 1 [Homo sapiens] 91 6e-18
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 73 1e-12
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 71 5e-12
gi|224994173 roundabout 1 isoform d [Homo sapiens] 69 2e-11
gi|224994171 roundabout 1 isoform c [Homo sapiens] 69 2e-11
gi|19743806 roundabout 1 isoform b [Homo sapiens] 69 2e-11
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 69 2e-11
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 69 2e-11
gi|4506569 roundabout 1 isoform a [Homo sapiens] 69 2e-11
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 66 1e-10
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 66 2e-10
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 66 2e-10
gi|83281200 protogenin [Homo sapiens] 63 1e-09
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 61 5e-09
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens] 60 1e-08
gi|189242612 complement component 6 precursor [Homo sapiens] 59 2e-08
gi|169636415 complement component 6 precursor [Homo sapiens] 59 2e-08
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 58 4e-08
gi|4557389 complement component 8, alpha polypeptide precursor [... 57 9e-08
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 56 2e-07
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 55 2e-07
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 55 3e-07
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 55 3e-07
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 55 3e-07
gi|147904700 semaphorin 5A [Homo sapiens] 55 4e-07
>gi|62243567 netrin receptor Unc5h1 [Homo sapiens]
Length = 842
Score = 1724 bits (4464), Expect = 0.0
Identities = 842/842 (100%), Positives = 842/842 (100%)
Query: 1 MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP 60
MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP
Sbjct: 1 MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP 60
Query: 61 VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE 120
VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE
Sbjct: 61 VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE 120
Query: 121 EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE 180
EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE
Sbjct: 121 EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE 180
Query: 181 VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY 240
VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY
Sbjct: 181 VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY 240
Query: 241 VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGP 300
VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGP
Sbjct: 241 VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGP 300
Query: 301 EDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADN 360
EDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADN
Sbjct: 301 EDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADN 360
Query: 361 PHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE 420
PHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE
Sbjct: 361 PHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE 420
Query: 421 EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYL 480
EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYL
Sbjct: 421 EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYL 480
Query: 481 TLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSC 540
TLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSC
Sbjct: 481 TLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSC 540
Query: 541 EGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAP 600
EGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAP
Sbjct: 541 EGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAP 600
Query: 601 VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVP 660
VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVP
Sbjct: 601 VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVP 660
Query: 661 SSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSF 720
SSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSF
Sbjct: 661 SSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSF 720
Query: 721 SINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTL 780
SINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTL
Sbjct: 721 SINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTL 780
Query: 781 AQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEA 840
AQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEA
Sbjct: 781 AQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEA 840
Query: 841 EC 842
EC
Sbjct: 841 EC 842
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 906 bits (2341), Expect = 0.0
Identities = 464/911 (50%), Positives = 612/911 (67%), Gaps = 84/911 (9%)
Query: 9 PALLGIVLAAWLRGSGAQQSA---TVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVC 65
PAL +L+A GS AQ + P P+ LPHFL+EPE+ YIVKNKPV L C
Sbjct: 26 PALA--LLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYC 83
Query: 66 KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQ 125
KA PATQI+FKCN EWV Q DH+++ D +SGL EV I +SRQQVE++FG E+YWCQ
Sbjct: 84 KASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQ 143
Query: 126 CVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLR 185
CVAWSS+GTTKS+KAY+RIAYLRK FEQEPL KEVSLEQ ++L CRPPEGIP AEVEWL+
Sbjct: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
Query: 186 NEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVDGSW 245
NED++DP D N YIT +H+L+++QARL+DTANYTCVAKNIVA+R+S +A VIVYV+G W
Sbjct: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGW 263
Query: 246 SPWSKWSACGLDC-------------------------------------------THW- 261
S W++WS C C T W
Sbjct: 264 STWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWS 323
Query: 262 ------------RSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGPEDVALYVGL 309
R REC+ PAP+NGG++C G L ++NCT LC+ TA +DVALYVG+
Sbjct: 324 KWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGI 383
Query: 310 -IAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQP 368
IAV VCL + ++V + VY + +SD+ DSS L GFQPV+IK ++ D LL + P
Sbjct: 384 VIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQD---LLAVPP 440
Query: 369 DLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSS----PTSEAEEFVS 424
DL++ Y+G + D S K +TN +L PL + ++++S P + EF S
Sbjct: 441 DLTSAAAMYRGPVYALHD-VSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTS 499
Query: 425 RLS---TQNYF---------RSLPRGT--SNMTYGTFNFLGGRLMIPNTGISLLIPPDAI 470
+LS TQ+ +SL R T S +G+FN LGG L++PN+G+SLLIP AI
Sbjct: 500 KLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAI 559
Query: 471 PRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDS 530
P+G++YE+Y+T+H+ E +R P+ QTLL+P+VSCGPPG LLTRPV+L M HC +P+ +
Sbjct: 560 PQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTED 619
Query: 531 WSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAA 590
W + LK Q+ +G WEDV+ +GEE + Y +L+A AC++ TE L +ALVG + + AAA
Sbjct: 620 WKILLKNQAAQGQWEDVVVVGEENFTTPCYIKLDAEACHILTENLSTYALVGHSTTKAAA 679
Query: 591 KRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYH 650
KRLKL +F P+ C+SLEY+IRVYCL DT DALKE++ LE+Q GGQL++EP+ LHFK S H
Sbjct: 680 KRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQTGGQLLEEPKALHFKGSTH 739
Query: 651 NLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWV 710
NLRLSIHD+ SLWKSKLL YQEIPFYH+W+G+QR LHCTFTLER S +T +L CKL V
Sbjct: 740 NLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCV 799
Query: 711 WQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPP 770
QVEG+GQ F +N ++++ +L L+ + + GPSAF IP IRQK+ SSLD P
Sbjct: 800 RQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAP 859
Query: 771 CRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQP 830
RG DWR LA KL+LD +L++FA+K SPT +IL+LWEA++FP+GNLS LAA + +G+
Sbjct: 860 QTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRH 919
Query: 831 DAGLFTVSEAE 841
+ + +E +
Sbjct: 920 ETVVSLAAEGQ 930
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 831 bits (2146), Expect = 0.0
Identities = 450/948 (47%), Positives = 593/948 (62%), Gaps = 109/948 (11%)
Query: 1 MAVRPGLWPALLGIVLAAW---LRGSGAQQSATVA-NPVPGANPDLLPHFLVEPEDVYIV 56
M R G ALL +L W L +G + V + P A + LP+FL EP+D YIV
Sbjct: 1 MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV 60
Query: 57 KNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKV 116
KNKPV L C+A PATQI+FKCNGEWV Q DHV + D ++GL EV+I VSRQQVE++
Sbjct: 61 KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL 120
Query: 117 FGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGI 176
FGLE+YWCQCVAWSS+GTTKS++AY+RIAYLRKNF+QEPL KEV L+ ++L CRPPEG+
Sbjct: 121 FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV 180
Query: 177 PPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAA 236
P AEVEWL+NED++DP+ D N +T +H+L++RQARL+DTANYTCVAKNIVA+RRS +A
Sbjct: 181 PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT 240
Query: 237 VIVYVDGSWSPWSKWSACGLDC-------------------------------------- 258
VIVYV+G WS W++WS C C
Sbjct: 241 VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP 300
Query: 259 -----THW-------------RSRECSDPAPRNGGEECQGTDLDTRNCTSDLCV------ 294
T W RSREC P P+NGG +C GT LD++NCT LC+
Sbjct: 301 VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL 360
Query: 295 -----HTASGPEDVALYVGL-IAVAVCLVLLLLVLILVYCRKKEGLDSDVADSS-ILTSG 347
H D ALY GL +A+ V + +L+ V ++VY R D+D+ DSS LT G
Sbjct: 361 SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG 420
Query: 348 FQPVSIKPSKADNPHLL--TIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGG 405
F PV+ K ++ NP LL ++ PDL+ + Y+G + QD + K +TN LL PL
Sbjct: 421 FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDS-TDKIPMTNSPLLDPLPS 479
Query: 406 GRHTLHHSSPT------SEAEEFVSRLSTQNY----------------------FRSLPR 437
+ ++ SS T ++ + + L Y LPR
Sbjct: 480 LKVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPR 539
Query: 438 GTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLA-GCQ 496
+ GTF LGGRL IP TG+SLL+P AIP+GK YE+YL ++K E LPL+ G Q
Sbjct: 540 DPGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAEST-LPLSEGTQ 598
Query: 497 TLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPS 556
T+LSP V+CGP G+LL RPVIL M HC E S W +LK Q+ +G WE+V+ L EE +
Sbjct: 599 TVLSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLN 658
Query: 557 HLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLH 616
YCQLE AC++ +QLG + GE+ S +A KRL+L +FAP CTSLEY++RVYCL
Sbjct: 659 TPCYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLE 718
Query: 617 DTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIP 676
DT ALKEV++LE+ LGG L++EP+ L FKDSYHNLRLS+HD+P + W+SKLL YQEIP
Sbjct: 719 DTPVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIP 778
Query: 677 FYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELL 736
FYHIW+G+Q+ LHCTFTLER S ++++L CK+ V QVEG+GQ F ++ + +T L
Sbjct: 779 FYHIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLA-ETPAGSLD 837
Query: 737 ALESEAG--VPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFA 794
L S G V +GP AFKIP IRQKI +SLD P RG DWR LAQKL +D +L++FA
Sbjct: 838 TLCSAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFA 897
Query: 795 SKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC 842
+K SPT +IL+LWEA +G+L+ LA+A+ +G+ + + ++ +C
Sbjct: 898 TKASPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC 945
>gi|209977117 unc-5 homolog D [Homo sapiens]
Length = 953
Score = 645 bits (1664), Expect = 0.0
Identities = 363/934 (38%), Positives = 523/934 (55%), Gaps = 111/934 (11%)
Query: 8 WPALLGIVLAAWLRGS----GAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLL 63
W LG L W G+ G + +P A P LPHF+ EP+D YI+K+ P+ L
Sbjct: 17 WLPWLG--LCFWAAGTAAARGTDNGEALPESIPSA-PGTLPHFIEEPDDAYIIKSNPIAL 73
Query: 64 VCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYW 123
CKA PA QIFFKCNGEWV Q +HV E + D SSGL EV INV+RQQVE G E+YW
Sbjct: 74 RCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQQVEDFHGPEDYW 133
Query: 124 CQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEW 183
CQCVAWS GT+KS+KA +RIAYLRKNFEQ+P +EV +E IVL CRPPEG+P AEVEW
Sbjct: 134 CQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEW 193
Query: 184 LRNE--------DLVDPSLDPNVYITREH------------SLVVRQARLADTA------ 217
L+NE + +D D N+ I + ++V ++ L+ T
Sbjct: 194 LKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNG 253
Query: 218 -----------NYTCVAKNIVARRRSAS--------------------AAVIVYVDGSWS 246
N C + R R+ + + VDGSW
Sbjct: 254 GWSSWTEWSACNVRC-GRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTSLCPVDGSWE 312
Query: 247 PWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCV-----------H 295
WS+WS C +C H R REC+ P PRNGG+ C+G ++ NCT LC+
Sbjct: 313 VWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQ 372
Query: 296 TASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKP 355
+ D+ALY GL AV V +L++ + +Y R + DV DSS LT GFQ + K
Sbjct: 373 SIENASDIALYSGL-GAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKT 431
Query: 356 SKADNPHLL--TIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHS 413
+ N LL +QPDL T + TY G +C + P K +T L +PL + + S
Sbjct: 432 VRQGNSLLLNSAMQPDL-TVSRTYSGPICLQD--PLDKELMTESSLFNPLSDIKVKVQSS 488
Query: 414 SPTSEAEEFVSRLSTQNYFRSLPRG--------------------------TSNMTYGTF 447
S + +N+ R+ P G T T G F
Sbjct: 489 FMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVF 548
Query: 448 NFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGP 507
LGGRL++PNTG+SLLIP AIP +EIY+++++ E L G + LLSP V+CGP
Sbjct: 549 GHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEP-SLQSDGSEVLLSPEVTCGP 607
Query: 508 PGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASA 567
P +++T P L + HC + S + W++ LKK++ +G WE+V+ + +E+ S YC L+ A
Sbjct: 608 PDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTS--CYCLLDPFA 665
Query: 568 CYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQ 627
C+V + G +AL GE ++ A K+LK+ +F ++C SL+YN+RVYC+ +T A +EVV
Sbjct: 666 CHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVS 725
Query: 628 LEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRY 687
E+ GGQL++EP++LHFK + +L++S+ D+P LW+ K + QE+PF +W ++
Sbjct: 726 DERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQP 785
Query: 688 LHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPAL 747
LHC F+LER +P+T+ L+CK+ + Q++G Q + +I + R + ++ PA
Sbjct: 786 LHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQ 845
Query: 748 VGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLW 807
GP AFKIP+ IRQ+I ++ D P +G DW+ LAQK ++ +LS+FA++ SP+A+ILNLW
Sbjct: 846 TGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLW 905
Query: 808 EARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAE 841
EARH +G+L LA A+ +G+ L +SE++
Sbjct: 906 EARHQHDGDLDSLACALEEIGRTHTKLSNISESQ 939
>gi|27734865 unc-5 homolog C-like [Homo sapiens]
Length = 518
Score = 99.8 bits (247), Expect = 1e-20
Identities = 102/386 (26%), Positives = 167/386 (43%), Gaps = 42/386 (10%)
Query: 451 GGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGV 510
GG LM+ +TGISLLIPP A+ G+ + L L L+ Q L+SP+V+CGP G
Sbjct: 112 GGCLMLQDTGISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSQAQGLVSPVVACGPHGA 171
Query: 511 LLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGS-WEDVLHLGEEAPSHLYYCQLEASACY 569
+P L HC E + + + W + G A C
Sbjct: 172 SFLKPCTLTFKHCAEQPSHARTYSSNTTLLDAKVWRPLGRPGAHA---------SRDECR 222
Query: 570 VFTEQLGRFALVGEA-LSVAAAKRLKLLLF-APVACTSLEYNIRVYCLHDTHDALKEVVQ 627
+ + V EA + A K L+L +F +P+ +R+Y L++T AL+ +
Sbjct: 223 IHLSHFSLYTCVLEAPVGREARKWLQLAVFCSPLVPGQSHLQLRIYFLNNTPCALQWALT 282
Query: 628 LEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRY 687
E+ GG+L ++ F + + L + + S W++ S Q +P HIW+G +
Sbjct: 283 NEQPHGGRLRGPCQLFDFNGARGDQCLKLTYI-SEGWENVDDSSCQLVPHLHIWHGKCPF 341
Query: 688 LHCTFTL------ERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESE 741
F E S T+++ + +Q DG +T++ E+L ++
Sbjct: 342 RSFCFRRKAADENEDCSALTNEIIVTMHTFQ---DG----------LETKYMEILRFQAS 388
Query: 742 ------AGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHL-DSHLSFFA 794
A P P ++P + +++ L+P G DWR LA L L + F +
Sbjct: 389 EEESWAAPPPVSQPPPCNRLPPELFEQLRMLLEPNSITGNDWRGLASHLGLCGMKIRFLS 448
Query: 795 SKPSPTAMILNLWEARHFPNGNLSQL 820
+ SP A IL L+E + NG+L +L
Sbjct: 449 CQRSPAAAILELFEEQ---NGSLQEL 471
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 90.5 bits (223), Expect = 6e-18
Identities = 51/143 (35%), Positives = 74/143 (51%), Gaps = 7/143 (4%)
Query: 154 EPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARL 213
EP+ ++ I+L C+ G P + W R + S D V + +SL + A+
Sbjct: 4445 EPVETVINAGGKIILNCQAT-GEPQPTITWSRQGHSI--SWDDRVNVLSNNSLYIADAQK 4501
Query: 214 ADTANYTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDC---THWRSRECSDPA 270
DT+ + CVA+N++ VIV V G +S WS W AC + C RSR C+ P
Sbjct: 4502 EDTSEFECVARNLMGSVL-VRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPL 4560
Query: 271 PRNGGEECQGTDLDTRNCTSDLC 293
P NGG+ CQG+DL+ RNC + C
Sbjct: 4561 PANGGKPCQGSDLEMRNCQNKPC 4583
Score = 63.5 bits (153), Expect = 8e-10
Identities = 24/56 (42%), Positives = 35/56 (62%), Gaps = 3/56 (5%)
Query: 241 VDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
+ G W+ W+ WSAC + C R+R CSDP P+ GG +C+G+D+ + C SD C
Sbjct: 4699 IHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPC 4754
Score = 58.2 bits (139), Expect = 3e-08
Identities = 54/186 (29%), Positives = 84/186 (45%), Gaps = 24/186 (12%)
Query: 49 EPEDVYIVKNKPVLLVCKA--VPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRI 106
E E++ ++ N P+ L C A +PA ++ + +G + Q D V T G + +
Sbjct: 3534 EHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQV---QTLGGGEV------L 3584
Query: 107 NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFE--QEPLAKEVSLEQ 164
+S QVE Y C +SS K Y+ ++ N EP V +
Sbjct: 3585 RISTAQVEDT---GRYTCL----ASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNR 3637
Query: 165 GIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYI-TREHSLVVRQARLADTANYTCVA 223
+ L C+ + +PP + WLRN + + + P V I + L + A L DTANYTCVA
Sbjct: 3638 QVTLECKS-DAVPPPVITWLRNGERLQAT--PRVRILSGGRYLQINNADLGDTANYTCVA 3694
Query: 224 KNIVAR 229
NI +
Sbjct: 3695 SNIAGK 3700
Score = 58.2 bits (139), Expect = 3e-08
Identities = 23/54 (42%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 243 GSWSPWSKWSACGLDCTHW---RSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
G+WSPWS W C C R R C +P P NGG C G D + C +D+C
Sbjct: 4758 GNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMC 4811
Score = 50.8 bits (120), Expect = 5e-06
Identities = 24/61 (39%), Positives = 33/61 (54%), Gaps = 4/61 (6%)
Query: 241 VDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC-VHT 296
VDGSWS WS W C C R+R C++P+ ++GG C+G ++ C C VH
Sbjct: 4585 VDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHG 4644
Query: 297 A 297
A
Sbjct: 4645 A 4645
Score = 48.9 bits (115), Expect = 2e-05
Identities = 21/56 (37%), Positives = 21/56 (37%), Gaps = 3/56 (5%)
Query: 241 VDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
VDGSW W WS C C R R C P P GG C G C C
Sbjct: 4813 VDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQAC 4868
Score = 48.5 bits (114), Expect = 3e-05
Identities = 47/185 (25%), Positives = 74/185 (40%), Gaps = 20/185 (10%)
Query: 49 EPEDVYIVKNKPVLLVCK--AVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRI 106
EP D+ +++N+ V L CK AVP I + NGE ++ V R G L +
Sbjct: 3627 EPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRV--RILSGGRYLQINNADL 3684
Query: 107 NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGI 166
+ CVA + +G K+ + +I + N + P + + L +
Sbjct: 3685 GDTANYT------------CVASNIAG--KTTREFILTVNVPPNIKGGPQSLVILLNKST 3730
Query: 167 VLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNI 226
VL C EG+P + W R + V I L ++ A + DT Y C+A N
Sbjct: 3731 VLECIA-EGVPTPRITW-RKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNA 3788
Query: 227 VARRR 231
R
Sbjct: 3789 AGTDR 3793
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/199 (21%), Positives = 88/199 (44%), Gaps = 30/199 (15%)
Query: 49 EPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINV 108
+P +++++ N P+LL C+A F E + + S + LP+ ++I+
Sbjct: 3993 QPSELHVILNNPILLPCEATGTPSPFITWQKEGIN-----VNTSGRNHAVLPSGGLQISR 4047
Query: 109 SRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKE------VSL 162
+ ++ + CVA + +GT + ++ N + P+ +++
Sbjct: 4048 AVREDAGTY-------MCVAQNPAGTA--------LGKIKLNVQVPPVISPHLKEYVIAV 4092
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCV 222
++ I L C +G+PP ++ W ++ + S+ V SL + + D +YTC+
Sbjct: 4093 DKPITLSCE-ADGLPPPDITWHKDGRAIVESIRQRV--LSSGSLQIAFVQPGDAGHYTCM 4149
Query: 223 AKNIVARRRSASAAVIVYV 241
A N VA S S + V+V
Sbjct: 4150 AAN-VAGSSSTSTKLTVHV 4167
Score = 48.1 bits (113), Expect = 3e-05
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 241 VDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
V G+WS W W C C T R+R C++P P GG C G + + C C
Sbjct: 4642 VHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNC 4697
Score = 47.4 bits (111), Expect = 6e-05
Identities = 50/188 (26%), Positives = 82/188 (43%), Gaps = 30/188 (15%)
Query: 50 PEDVYIVKNKPVLLVCKAV---PATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRI 106
PEDV ++ N P LVC+A PAT +FK DG+ +RI
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFK-----------------DGTPLESNRNIRI 2624
Query: 107 NVSRQQVEKVFGLEEYWCQ--CVAWSSSGTTKSQ---KAYIRIAYLRKNFEQEPLA-KEV 160
+ ++ + E+ + CVA + +G K YI + + L+ KEV
Sbjct: 2625 LPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEV 2684
Query: 161 SLEQG--IVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTAN 218
++ + L C IP A + W ++ + N+ H+L +++A+++DT
Sbjct: 2685 KIKVNNTLTLECEA-YAIPSASLSWYKDGQPLKSDDHVNI-AANGHTLQIKEAQISDTGR 2742
Query: 219 YTCVAKNI 226
YTCVA NI
Sbjct: 2743 YTCVASNI 2750
Score = 44.7 bits (104), Expect = 4e-04
Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 3/116 (2%)
Query: 126 CVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLR 185
C A + G +S+ + P V Q + LPC G P E W++
Sbjct: 867 CEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK 926
Query: 186 NEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYV 241
N ++ +P + + + SL + + +L D YTCVA N VA + + +V+V+V
Sbjct: 927 NSAML--LQNPYITVRSDGSLHIERVQLQDGGEYTCVASN-VAGTNNKTTSVVVHV 979
Score = 44.7 bits (104), Expect = 4e-04
Identities = 55/220 (25%), Positives = 90/220 (40%), Gaps = 43/220 (19%)
Query: 35 VPGANPDLLPHFLVEPEDVYIVKNKPVLLVC--KAVPATQIFFKCNGEWVRQVDHVIERS 92
+ GAN DL PE+V ++ NK L+ C PA + ++ +G+ + + DH +
Sbjct: 2871 IKGANSDL-------PEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDH--HKF 2921
Query: 93 TDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFE 152
L + +I + V CVA +++G+ K Y N
Sbjct: 2922 LSNGRILQILNTQITDIGRYV------------CVAENTAGSAKK--------YFNLNVH 2961
Query: 153 QEPLA-------KEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYIT-REH 204
P V + I L C G PP ++ WL+NE + L+ N I
Sbjct: 2962 VPPSVIGPKSENLTVVVNNFISLTCEV-SGFPPPDLSWLKNEQPI--KLNTNTLIVPGGR 3018
Query: 205 SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVDGS 244
+L + +A+++D YTC+A N A ++ VYV S
Sbjct: 3019 TLQIIRAKVSDGGEYTCIAIN-QAGESKKKFSLTVYVPPS 3057
Score = 43.5 bits (101), Expect = 8e-04
Identities = 46/181 (25%), Positives = 80/181 (44%), Gaps = 23/181 (12%)
Query: 53 VYIVKNKPVLLVCKA--VPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSR 110
V +V N PV L C+A +PA + + +G V + ++ + G T + R
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGR 2080
Query: 111 QQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPC 170
CVA +++G K + +R+ Y+ N E V + Q + L C
Sbjct: 2081 YT-------------CVAVNAAGE-KQRDIDLRV-YVPPNIMGEEQNVSVLISQAVELLC 2125
Query: 171 RPPEGIPPAEVEWLRNEDLVDPSLD-PNVYITREHSLV-VRQARLADTANYTCVAKNIVA 228
+ + IPP + WL++ P L P + I+ S++ + A++ DT YTC A N+
Sbjct: 2126 QS-DAIPPPTLTWLKDGH---PLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG 2181
Query: 229 R 229
+
Sbjct: 2182 K 2182
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 7/104 (6%)
Query: 126 CVAWSSSGTTKSQKAYIRIAYLRK---NFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVE 182
CVA + +GT K K Y Y+R N P V+ + I L C +GIPP V
Sbjct: 2269 CVASNVAGTAK--KEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPPPTVT 2325
Query: 183 WLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNI 226
W+++ + + + + H L ++ ++DT Y CVA N+
Sbjct: 2326 WMKDGHPLIKAKGVEI-LDEGHILQLKNIHVSDTGRYVCVAVNV 2368
Score = 41.6 bits (96), Expect = 0.003
Identities = 46/193 (23%), Positives = 83/193 (43%), Gaps = 25/193 (12%)
Query: 40 PDLLPHFLVEPEDVYIVKNKPVLLVCK--AVPATQIFFKCNGEWVRQVDHVIERSTDGSS 97
P + H V + + V L C+ AVP I + NG + + HV E DG
Sbjct: 3056 PSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHV-EILADGQM 3114
Query: 98 GLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFE---QE 154
+++ + +V +Y C+ + + + K + Y+ + E +E
Sbjct: 3115 --------LHIKKAEVSDT---GQYVCRAINVAG----RDDKNFHLNVYVPPSIEGPERE 3159
Query: 155 PLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHS-LVVRQARL 213
+ + +S + L C GIPP + WL+N ++ S V I S L + +++
Sbjct: 3160 VIVETIS--NPVTLTC-DATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQH 3216
Query: 214 ADTANYTCVAKNI 226
+D+ NYTC+A N+
Sbjct: 3217 SDSGNYTCIASNM 3229
Score = 40.4 bits (93), Expect = 0.007
Identities = 47/190 (24%), Positives = 79/190 (41%), Gaps = 22/190 (11%)
Query: 43 LPHFLVEPEDVYIVK--NKPVLLVCKA--VPATQIFFKCNGEWVRQVDHVIERSTDGSSG 98
+P + PE IV+ + PV L C A +P I + N + + D + R G S
Sbjct: 3149 VPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGS- 3207
Query: 99 LPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAK 158
++ ++R Q C+A + G K+QK Y + + +
Sbjct: 3208 ------KLQIARSQHSDSGNYT-----CIASNMEG--KAQKYYFLSIQVPPSVAGAEIPS 3254
Query: 159 EVS--LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHS-LVVRQARLAD 215
+VS L + + L C GIP ++WL++ + + ++ S L + A +D
Sbjct: 3255 DVSVLLGENVELVCNA-NGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSD 3313
Query: 216 TANYTCVAKN 225
T YTCVA N
Sbjct: 3314 TGKYTCVATN 3323
Score = 40.0 bits (92), Expect = 0.009
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 12/108 (11%)
Query: 126 CVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLR 185
C+A +S+GT K I + Q L V+L V+ C+ GIPP +V+W +
Sbjct: 681 CLASNSAGTDKQNSTLRYIEAPKLMVVQSELL--VALGDITVMECKT-SGIPPPQVKWFK 737
Query: 186 NEDLVDPS----LDPNVYITREHSLVVRQARLADTANYTCVAKNIVAR 229
+ + PS +DP + + L +++ + D +YTCVA N R
Sbjct: 738 GDLELRPSTFLIIDPLLGL-----LKIQETQDLDAGDYTCVAINEAGR 780
Score = 38.5 bits (88), Expect = 0.026
Identities = 45/181 (24%), Positives = 73/181 (40%), Gaps = 21/181 (11%)
Query: 50 PEDVYIVKNKPVLLVCKA--VPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRIN 107
P DV ++ + V LVC A +P I +W++ + T+ + V N
Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLI------QWLKDGKPIASGETE------RIRVSAN 3300
Query: 108 VSRQQVEKVFGLEEYWCQCVAWSSSGTTK---SQKAYIRIAYLRKNFEQEPLAKEVSLEQ 164
S + + CVA + +G + Y+ E E L V +
Sbjct: 3301 GSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLV--DT 3358
Query: 165 GIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAK 224
I + CR G PP ++ WL+N + S + + +VR A+++D A YTCVA
Sbjct: 3359 SINIECRAT-GTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVR-AQVSDVAVYTCVAS 3416
Query: 225 N 225
N
Sbjct: 3417 N 3417
Score = 37.0 bits (84), Expect = 0.077
Identities = 27/109 (24%), Positives = 54/109 (49%), Gaps = 10/109 (9%)
Query: 126 CVAWSSSGTTKSQKAYIRIAYLR---KNFEQEPLAKEVSLEQG--IVLPCRPPEGIPPAE 180
C+A + +G +S+K + Y+ K+ + E L+ V++ +G + L C +PP
Sbjct: 3035 CIAINQAG--ESKKKFSLTVYVPPSIKDHDSESLSV-VNVREGTSVSLECES-NAVPPPV 3090
Query: 181 VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVAR 229
+ W +N ++ S + + L +++A ++DT Y C A N+ R
Sbjct: 3091 ITWYKNGRMITESTHVEI-LADGQMLHIKKAEVSDTGQYVCRAINVAGR 3138
Score = 36.6 bits (83), Expect = 0.100
Identities = 26/107 (24%), Positives = 47/107 (43%), Gaps = 3/107 (2%)
Query: 125 QCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWL 184
+CVA +S+G T + Y ++ + V + + L C GIP + WL
Sbjct: 1990 KCVAINSAGAT--ELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEA-RGIPAPSLTWL 2046
Query: 185 RNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRR 231
++ V + ++ L + A+++DT YTCVA N ++
Sbjct: 2047 KDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQ 2093
Score = 35.0 bits (79), Expect = 0.29
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 175 GIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKN 225
G PP + WL++ L+D D + LV+ QA++++T Y C+A N
Sbjct: 1760 GSPPPTIMWLKDGQLIDER-DGFKILLNGRKLVIAQAQVSNTGLYRCMAAN 1809
Score = 35.0 bits (79), Expect = 0.29
Identities = 41/184 (22%), Positives = 71/184 (38%), Gaps = 20/184 (10%)
Query: 44 PHFLVEPEDVYIVKNKPVLLVCKA--VPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPT 101
P EP D + K+ P ++ C A VP I + NG +R + S +
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNG--IRLLPRGDGYRILSSGAIEI 3954
Query: 102 MEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVS 161
+ ++N + + CVA +++G+ + + + + +P V
Sbjct: 3955 LATQLNHAGRYT------------CVARNAAGS--AHRHVTLHVHEPPVIQPQPSELHVI 4000
Query: 162 LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTC 221
L I+LPC G P + W + V+ S N + L + +A D Y C
Sbjct: 4001 LNNPILLPCE-ATGTPSPFITWQKEGINVNTS-GRNHAVLPSGGLQISRAVREDAGTYMC 4058
Query: 222 VAKN 225
VA+N
Sbjct: 4059 VAQN 4062
Score = 34.7 bits (78), Expect = 0.38
Identities = 25/101 (24%), Positives = 47/101 (46%), Gaps = 4/101 (3%)
Query: 126 CVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLR 185
C+A +++GT + ++ +++ ++ + P V + L C GIP + W +
Sbjct: 3783 CMATNAAGTDR-RRIDLQV-HVPPSIAPGPTNMTVIVNVQTTLACEAT-GIPKPSINWRK 3839
Query: 186 NEDLVDPSLDPNVY-ITREHSLVVRQARLADTANYTCVAKN 225
N L++ + N Y + SLV+ + DTA Y C N
Sbjct: 3840 NGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880
Score = 33.5 bits (75), Expect = 0.85
Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 22/196 (11%)
Query: 50 PEDVYIVKNKPVLLVC--KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRIN 107
P +V +V N+ V L C K P I + +G+ + D +E D L R N
Sbjct: 1460 PNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVEL-LDRGQVLHLKNARRN 1518
Query: 108 VSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVS--LEQG 165
+ QC +++G K K Y+ + + + ++S +
Sbjct: 1519 DKGRY------------QCTVSNAAG--KQAKDIKLTIYIPPSIKGGNVTTDISVLINSL 1564
Query: 166 IVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKN 225
I L C G+P + W ++ + S +YI + L + +A+++D+A YTC N
Sbjct: 1565 IKLECET-RGLPMPAITWYKDGQPIMSSSQA-LYIDKGQYLHIPRAQVSDSATYTCHVAN 1622
Query: 226 IVARRRSASAAVIVYV 241
VA S V VYV
Sbjct: 1623 -VAGTAEKSFHVDVYV 1637
Score = 33.1 bits (74), Expect = 1.1
Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 6/77 (7%)
Query: 155 PLAKEVSLEQGIVLPCRP------PEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVV 208
P K L + +V+ +P GIP + WL+++ V+ + + L +
Sbjct: 1826 PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQI 1885
Query: 209 RQARLADTANYTCVAKN 225
+ L D YTCVA N
Sbjct: 1886 AKTLLEDAGRYTCVATN 1902
Score = 32.7 bits (73), Expect = 1.4
Identities = 21/74 (28%), Positives = 35/74 (47%), Gaps = 6/74 (8%)
Query: 156 LAKEVSLEQG--IVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARL 213
L +VSL +G + L C+ GIP ++ W N +++ D + LV+ +
Sbjct: 4265 LPGDVSLNKGEQLRLSCKAT-GIPLPKLTWTFNNNIIPAHFDS---VNGHSELVIERVSK 4320
Query: 214 ADTANYTCVAKNIV 227
D+ Y C A+N V
Sbjct: 4321 EDSGTYVCTAENSV 4334
Score = 30.8 bits (68), Expect = 5.5
Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 3/63 (4%)
Query: 164 QGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHS-LVVRQARLADTANYTCV 222
Q I PC P +G P ++WL N + +P + I + + LV+ D Y CV
Sbjct: 1282 QRIEFPC-PAKGTPKPTIKWLHNGREL-TGREPGISILEDGTLLVIASVTPYDNGEYICV 1339
Query: 223 AKN 225
A N
Sbjct: 1340 AVN 1342
Score = 30.8 bits (68), Expect = 5.5
Identities = 45/189 (23%), Positives = 77/189 (40%), Gaps = 28/189 (14%)
Query: 42 LLPHFLVEPEDVYIVKNKPVLLVCKA--VPATQIFFKCNGEWVRQVDHVIERSTDGSSGL 99
+LP F P DV + K + + L CKA +P ++ + N +++I D +G
Sbjct: 4258 VLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFN-------NNIIPAHFDSVNG- 4309
Query: 100 PTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKN--FEQEPLA 157
S +E+V + C A +S G K+ I Y+++ F+ + +
Sbjct: 4310 --------HSELVIERVSKEDSGTYVCTAENSVGFVKA----IGFVYVKEPPVFKGDYPS 4357
Query: 158 KEVS-LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
+ L +L C +G P ++W N VD + + SL + D
Sbjct: 4358 NWIEPLGGNAILNCE-VKGDPTPTIQW--NRKGVDIEISHRIRQLGNGSLAIYGTVNEDA 4414
Query: 217 ANYTCVAKN 225
+YTCVA N
Sbjct: 4415 GDYTCVATN 4423
Score = 30.4 bits (67), Expect = 7.2
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 2/69 (2%)
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
AK+V + I L C PP + W ++ + S D + + L + +A++ D
Sbjct: 2786 AKDVIINNPISLYCET-NAAPPPTLTWYKDGHPLTSS-DKVLILPGGRVLQIPRAKVEDA 2843
Query: 217 ANYTCVAKN 225
YTCVA N
Sbjct: 2844 GRYTCVAVN 2852
Score = 30.4 bits (67), Expect = 7.2
Identities = 26/104 (25%), Positives = 50/104 (48%), Gaps = 10/104 (9%)
Query: 126 CVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQG--IVLPCRPPEGIPPAEVEW 183
CVA + +G K Y + N + +E+++ +G + C +G P + W
Sbjct: 3413 CVASNRAGV--DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACIT-DGTPAPSMAW 3469
Query: 184 LRNEDLVDPSLDPNVYITREHSLVVR--QARLADTANYTCVAKN 225
LR+ + LD ++ ++ H +V++ +A D+ YTC+A N
Sbjct: 3470 LRDGQPL--GLDAHLTVST-HGMVLQLLKAETEDSGKYTCIASN 3510
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 73.2 bits (178), Expect = 1e-12
Identities = 67/241 (27%), Positives = 104/241 (43%), Gaps = 28/241 (11%)
Query: 9 PALLGIVLAAW-LRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKA 67
P LL + + W +G+G Q + + D P + P DV + K +P L CKA
Sbjct: 17 PGLLMMTVVFWGHQGNGQGQGSRLRQE------DFPPRIVEHPSDVIVSKGEPTTLNCKA 70
Query: 68 V--PATQIFFKCNGEWVRQVDHVIERSTDGSSG---LPTMEV---RINVSRQQVEKVFGL 119
P I EW + + V D S LP+ + RI R+
Sbjct: 71 EGRPTPTI------EWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP----- 119
Query: 120 EEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPA 179
+E CVA + G S+ A + +A LR +F Q P V+ + +L C+PP G P
Sbjct: 120 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEP 179
Query: 180 EVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIV 239
+ W +++ +D + + I R L++ R +D YTCV N+V R S A + V
Sbjct: 180 TIYWKKDKVRIDDK-EERISI-RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV 237
Query: 240 Y 240
+
Sbjct: 238 F 238
Score = 53.1 bits (126), Expect = 1e-06
Identities = 46/185 (24%), Positives = 78/185 (42%), Gaps = 13/185 (7%)
Query: 44 PHFLVEPEDVYIVKNKPVLLVC--KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPT 101
P F+V P D + + + V C K P +F++ G + ++ S PT
Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389
Query: 102 MEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKN--FEQEPLAK 158
++ I N+ R Y CQ + + S K+Q + R Q P +
Sbjct: 390 GDLTITNIQRSDAGY------YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQ 443
Query: 159 EVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTAN 218
++++ +L C+ G P + WL+ E P DP I + +L ++ R++DT
Sbjct: 444 TLAVDGTALLKCKAT-GDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLRISDTGT 501
Query: 219 YTCVA 223
YTCVA
Sbjct: 502 YTCVA 506
Score = 38.9 bits (89), Expect = 0.020
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 25/197 (12%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P +L C + P I++K + ++D ER
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV---RIDDKEER----------- 196
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
+ I + + + CV + G S A + + + R F + P+ + V
Sbjct: 197 -ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLE 254
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNE-DLVDPSLDPNVYITREHSLVVRQARLADTANYTC 221
E+ + C+ +G P V W +++ DL D I +++L +++ D Y C
Sbjct: 255 EEAVEFRCQV-QGDPQPTVRWKKDDADLPRGRYD----IKDDYTLRIKKTMSTDEGTYMC 309
Query: 222 VAKNIVARRRSASAAVI 238
+A+N V + +++ +
Sbjct: 310 IAENRVGKMEASATLTV 326
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 70.9 bits (172), Expect = 5e-12
Identities = 60/208 (28%), Positives = 91/208 (43%), Gaps = 21/208 (10%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVRQVDHVIERSTDGSSG 98
D P + P DV + K +P L CKA P I EW + + V D S
Sbjct: 28 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTI------EWYKDGERVETDKDDPRSH 81
Query: 99 ---LPTMEV---RINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFE 152
LP+ + RI R+ +E CVA + G S+ A + +A LR +F
Sbjct: 82 RMLLPSGSLFFLRIVHGRRSKP-----DEGSYVCVARNYLGEAVSRNASLEVALLRDDFR 136
Query: 153 QEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQAR 212
Q P V+ + +L C+PP G P + W +++ +D + + I R L++ R
Sbjct: 137 QNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDK-EERISI-RGGKLMISNTR 194
Query: 213 LADTANYTCVAKNIVARRRSASAAVIVY 240
+D YTCV N+V R S A + V+
Sbjct: 195 KSDAGMYTCVGTNMVGERDSDPAELTVF 222
Score = 53.1 bits (126), Expect = 1e-06
Identities = 46/185 (24%), Positives = 78/185 (42%), Gaps = 13/185 (7%)
Query: 44 PHFLVEPEDVYIVKNKPVLLVC--KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPT 101
P F+V P D + + + V C K P +F++ G + ++ S PT
Sbjct: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
Query: 102 MEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKN--FEQEPLAK 158
++ I N+ R Y CQ + + S K+Q + R Q P +
Sbjct: 374 GDLTITNIQRSDAGY------YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQ 427
Query: 159 EVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTAN 218
++++ +L C+ G P + WL+ E P DP I + +L ++ R++DT
Sbjct: 428 TLAVDGTALLKCKAT-GDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLRISDTGT 485
Query: 219 YTCVA 223
YTCVA
Sbjct: 486 YTCVA 490
Score = 38.9 bits (89), Expect = 0.020
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 25/197 (12%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P +L C + P I++K + ++D ER
Sbjct: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV---RIDDKEER----------- 180
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
+ I + + + CV + G S A + + + R F + P+ + V
Sbjct: 181 -ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLE 238
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNE-DLVDPSLDPNVYITREHSLVVRQARLADTANYTC 221
E+ + C+ +G P V W +++ DL D I +++L +++ D Y C
Sbjct: 239 EEAVEFRCQV-QGDPQPTVRWKKDDADLPRGRYD----IKDDYTLRIKKTMSTDEGTYMC 293
Query: 222 VAKNIVARRRSASAAVI 238
+A+N V + +++ +
Sbjct: 294 IAENRVGKMEASATLTV 310
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 13/203 (6%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVR--QVDHVIERSTDGS 96
D P + P D+ + K +P L CKA P I + GE V + D R S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 97 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL 156
L + + + E V+ CVA + G S A + +A LR +F Q P
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVY-------VCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
V++ + V+ C+PP G P + W ++ +D D + I R L++ R +D
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK-DERITI-RGGKLMITYTRKSDA 196
Query: 217 ANYTCVAKNIVARRRSASAAVIV 239
Y CV N+V R S A + V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTV 219
Score = 54.7 bits (130), Expect = 4e-07
Identities = 58/207 (28%), Positives = 91/207 (43%), Gaps = 23/207 (11%)
Query: 25 AQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWV 82
A+ SAT+ V G+ P PHF+V+P D + + V C+A P IF++ G
Sbjct: 300 AEASATLTVQV-GSEP---PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 355
Query: 83 RQVDHVIERSTDGSSGLPTMEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAY 141
+ +S+ S T ++ I NV R V Y CQ + + S TK AY
Sbjct: 356 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY------YICQTLNVAGSIITK---AY 406
Query: 142 IRIAYLRKN-----FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDP 196
+ + + + Q P+ + V+++ VL C G P + W ++ LV D
Sbjct: 407 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQ-DS 464
Query: 197 NVYITREHSLVVRQARLADTANYTCVA 223
+ L +R A+L DT YTC+A
Sbjct: 465 RIKQLENGVLQIRYAKLGDTGRYTCIA 491
Score = 47.0 bits (110), Expect = 7e-05
Identities = 52/205 (25%), Positives = 86/205 (41%), Gaps = 25/205 (12%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P ++ C + P I +K +G +D ER T L
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---PLDDKDERITIRGGKLMIT 189
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
R + + + V CV + G +S+ A + + R +F + P V++
Sbjct: 190 YTRKSDAGKYV------------CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCV 222
+ C G P V W +++ + S I +H+L +R+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 223 AKNIVARRRSASAAVIVYVDGSWSP 247
A+N+V + ASA + V V GS P
Sbjct: 293 AENMVG-KAEASATLTVQV-GSEPP 315
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 13/203 (6%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVR--QVDHVIERSTDGS 96
D P + P D+ + K +P L CKA P I + GE V + D R S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 97 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL 156
L + + + E V+ CVA + G S A + +A LR +F Q P
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVY-------VCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
V++ + V+ C+PP G P + W ++ +D D + I R L++ R +D
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK-DERITI-RGGKLMITYTRKSDA 196
Query: 217 ANYTCVAKNIVARRRSASAAVIV 239
Y CV N+V R S A + V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTV 219
Score = 54.7 bits (130), Expect = 4e-07
Identities = 58/207 (28%), Positives = 91/207 (43%), Gaps = 23/207 (11%)
Query: 25 AQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWV 82
A+ SAT+ V G+ P PHF+V+P D + + V C+A P IF++ G
Sbjct: 300 AEASATLTVQV-GSEP---PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 355
Query: 83 RQVDHVIERSTDGSSGLPTMEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAY 141
+ +S+ S T ++ I NV R V Y CQ + + S TK AY
Sbjct: 356 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY------YICQTLNVAGSIITK---AY 406
Query: 142 IRIAYLRKN-----FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDP 196
+ + + + Q P+ + V+++ VL C G P + W ++ LV D
Sbjct: 407 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQ-DS 464
Query: 197 NVYITREHSLVVRQARLADTANYTCVA 223
+ L +R A+L DT YTC+A
Sbjct: 465 RIKQLENGVLQIRYAKLGDTGRYTCIA 491
Score = 47.0 bits (110), Expect = 7e-05
Identities = 52/205 (25%), Positives = 86/205 (41%), Gaps = 25/205 (12%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P ++ C + P I +K +G +D ER T L
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---PLDDKDERITIRGGKLMIT 189
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
R + + + V CV + G +S+ A + + R +F + P V++
Sbjct: 190 YTRKSDAGKYV------------CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCV 222
+ C G P V W +++ + S I +H+L +R+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 223 AKNIVARRRSASAAVIVYVDGSWSP 247
A+N+V + ASA + V V GS P
Sbjct: 293 AENMVG-KAEASATLTVQV-GSEPP 315
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 13/203 (6%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVR--QVDHVIERSTDGS 96
D P + P D+ + K +P L CKA P I + GE V + D R S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 97 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL 156
L + + + E V+ CVA + G S A + +A LR +F Q P
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVY-------VCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
V++ + V+ C+PP G P + W ++ +D D + I R L++ R +D
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK-DERITI-RGGKLMITYTRKSDA 196
Query: 217 ANYTCVAKNIVARRRSASAAVIV 239
Y CV N+V R S A + V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTV 219
Score = 52.8 bits (125), Expect = 1e-06
Identities = 56/207 (27%), Positives = 88/207 (42%), Gaps = 26/207 (12%)
Query: 25 AQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWV 82
A+ SAT+ P PHF+V+P D + + V C+A P IF++ G
Sbjct: 300 AEASATLTVQEP-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 352
Query: 83 RQVDHVIERSTDGSSGLPTMEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAY 141
+ +S+ S T ++ I NV R V Y CQ + + S TK AY
Sbjct: 353 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY------YICQTLNVAGSIITK---AY 403
Query: 142 IRIAYLRKN-----FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDP 196
+ + + + Q P+ + V+++ VL C G P + W ++ LV D
Sbjct: 404 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQ-DS 461
Query: 197 NVYITREHSLVVRQARLADTANYTCVA 223
+ L +R A+L DT YTC+A
Sbjct: 462 RIKQLENGVLQIRYAKLGDTGRYTCIA 488
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/196 (22%), Positives = 81/196 (41%), Gaps = 23/196 (11%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P ++ C + P I +K +G +D ER T L
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---PLDDKDERITIRGGKLMIT 189
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
R + + + V CV + G +S+ A + + R +F + P V++
Sbjct: 190 YTRKSDAGKYV------------CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCV 222
+ C G P V W +++ + S I +H+L +R+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 223 AKNIVARRRSASAAVI 238
A+N+V + +++ +
Sbjct: 293 AENMVGKAEASATLTV 308
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 13/203 (6%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVR--QVDHVIERSTDGS 96
D P + P D+ + K +P L CKA P I + GE V + D R S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 97 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL 156
L + + + E V+ CVA + G S A + +A LR +F Q P
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVY-------VCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
V++ + V+ C+PP G P + W ++ +D D + I R L++ R +D
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK-DERITI-RGGKLMITYTRKSDA 196
Query: 217 ANYTCVAKNIVARRRSASAAVIV 239
Y CV N+V R S A + V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTV 219
Score = 54.7 bits (130), Expect = 4e-07
Identities = 58/207 (28%), Positives = 91/207 (43%), Gaps = 23/207 (11%)
Query: 25 AQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWV 82
A+ SAT+ V G+ P PHF+V+P D + + V C+A P IF++ G
Sbjct: 300 AEASATLTVQV-GSEP---PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 355
Query: 83 RQVDHVIERSTDGSSGLPTMEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAY 141
+ +S+ S T ++ I NV R V Y CQ + + S TK AY
Sbjct: 356 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY------YICQTLNVAGSIITK---AY 406
Query: 142 IRIAYLRKN-----FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDP 196
+ + + + Q P+ + V+++ VL C G P + W ++ LV D
Sbjct: 407 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQ-DS 464
Query: 197 NVYITREHSLVVRQARLADTANYTCVA 223
+ L +R A+L DT YTC+A
Sbjct: 465 RIKQLENGVLQIRYAKLGDTGRYTCIA 491
Score = 47.0 bits (110), Expect = 7e-05
Identities = 52/205 (25%), Positives = 86/205 (41%), Gaps = 25/205 (12%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P ++ C + P I +K +G +D ER T L
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---PLDDKDERITIRGGKLMIT 189
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
R + + + V CV + G +S+ A + + R +F + P V++
Sbjct: 190 YTRKSDAGKYV------------CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCV 222
+ C G P V W +++ + S I +H+L +R+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 223 AKNIVARRRSASAAVIVYVDGSWSP 247
A+N+V + ASA + V V GS P
Sbjct: 293 AENMVG-KAEASATLTVQV-GSEPP 315
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 13/203 (6%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVR--QVDHVIERSTDGS 96
D P + P D+ + K +P L CKA P I + GE V + D R S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 97 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL 156
L + + + E V+ CVA + G S A + +A LR +F Q P
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVY-------VCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
V++ + V+ C+PP G P + W ++ +D D + I R L++ R +D
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK-DERITI-RGGKLMITYTRKSDA 196
Query: 217 ANYTCVAKNIVARRRSASAAVIV 239
Y CV N+V R S A + V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTV 219
Score = 54.7 bits (130), Expect = 4e-07
Identities = 58/207 (28%), Positives = 91/207 (43%), Gaps = 23/207 (11%)
Query: 25 AQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWV 82
A+ SAT+ V G+ P PHF+V+P D + + V C+A P IF++ G
Sbjct: 300 AEASATLTVQV-GSEP---PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 355
Query: 83 RQVDHVIERSTDGSSGLPTMEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAY 141
+ +S+ S T ++ I NV R V Y CQ + + S TK AY
Sbjct: 356 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY------YICQTLNVAGSIITK---AY 406
Query: 142 IRIAYLRKN-----FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDP 196
+ + + + Q P+ + V+++ VL C G P + W ++ LV D
Sbjct: 407 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQ-DS 464
Query: 197 NVYITREHSLVVRQARLADTANYTCVA 223
+ L +R A+L DT YTC+A
Sbjct: 465 RIKQLENGVLQIRYAKLGDTGRYTCIA 491
Score = 47.0 bits (110), Expect = 7e-05
Identities = 52/205 (25%), Positives = 86/205 (41%), Gaps = 25/205 (12%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P ++ C + P I +K +G +D ER T L
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---PLDDKDERITIRGGKLMIT 189
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
R + + + V CV + G +S+ A + + R +F + P V++
Sbjct: 190 YTRKSDAGKYV------------CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 236
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCV 222
+ C G P V W +++ + S I +H+L +R+ D +YTCV
Sbjct: 237 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 223 AKNIVARRRSASAAVIVYVDGSWSP 247
A+N+V + ASA + V V GS P
Sbjct: 293 AENMVG-KAEASATLTVQV-GSEPP 315
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 13/203 (6%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVR--QVDHVIERSTDGS 96
D P + P D+ + K +P L CKA P I + GE V + D R S
Sbjct: 65 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
Query: 97 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL 156
L + + + E V+ CVA + G S A + +A LR +F Q P
Sbjct: 125 GSLFFLRIVHGRKSRPDEGVY-------VCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
V++ + V+ C+PP G P + W ++ +D D + I R L++ R +D
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK-DERITI-RGGKLMITYTRKSDA 235
Query: 217 ANYTCVAKNIVARRRSASAAVIV 239
Y CV N+V R S A + V
Sbjct: 236 GKYVCVGTNMVGERESEVAELTV 258
Score = 52.8 bits (125), Expect = 1e-06
Identities = 56/207 (27%), Positives = 88/207 (42%), Gaps = 26/207 (12%)
Query: 25 AQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWV 82
A+ SAT+ P PHF+V+P D + + V C+A P IF++ G
Sbjct: 339 AEASATLTVQEP-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 391
Query: 83 RQVDHVIERSTDGSSGLPTMEVRI-NVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAY 141
+ +S+ S T ++ I NV R V Y CQ + + S TK AY
Sbjct: 392 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY------YICQTLNVAGSIITK---AY 442
Query: 142 IRIAYLRKN-----FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDP 196
+ + + + Q P+ + V+++ VL C G P + W ++ LV D
Sbjct: 443 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQ-DS 500
Query: 197 NVYITREHSLVVRQARLADTANYTCVA 223
+ L +R A+L DT YTC+A
Sbjct: 501 RIKQLENGVLQIRYAKLGDTGRYTCIA 527
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/196 (22%), Positives = 81/196 (41%), Gaps = 23/196 (11%)
Query: 46 FLVEPEDVYIVKNKPVLLVC---KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM 102
F P DV + +P ++ C + P I +K +G +D ER T L
Sbjct: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---PLDDKDERITIRGGKLMIT 228
Query: 103 EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSL 162
R + + + V CV + G +S+ A + + R +F + P V++
Sbjct: 229 YTRKSDAGKYV------------CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTV 275
Query: 163 EQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCV 222
+ C G P V W +++ + S I +H+L +R+ D +YTCV
Sbjct: 276 DDSAEFKCEA-RGDPVPTVRWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCV 331
Query: 223 AKNIVARRRSASAAVI 238
A+N+V + +++ +
Sbjct: 332 AENMVGKAEASATLTV 347
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 66.2 bits (160), Expect = 1e-10
Identities = 57/203 (28%), Positives = 85/203 (41%), Gaps = 13/203 (6%)
Query: 41 DLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVRQV--DHVIERSTDGS 96
D +P + +P D+ + + +P L C+A P I + NG V V D R S
Sbjct: 61 DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
Query: 97 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL 156
L + + E V+ CVA + G S+ A + +A LR +F Q P
Sbjct: 121 GALFFPRIVHGRRARPDEGVY-------TCVARNYLGAAASRNASLEVAVLRDDFRQSPG 173
Query: 157 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT 216
V++ + VL C PP G P V W +D + R L++ +D
Sbjct: 174 NVVVAVGEPAVLECVPPRGHPEPSVSW--RKDGARLKEEEGRITIRGGKLMMSHTLKSDA 231
Query: 217 ANYTCVAKNIVARRRSASAAVIV 239
Y CVA N+ R SA+A V+V
Sbjct: 232 GMYVCVASNMAGERESAAAEVMV 254
Score = 44.7 bits (104), Expect = 4e-04
Identities = 36/116 (31%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 126 CVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLR 185
CVA + +G +S A + + R +F + P+ + V + + C +G PP + W R
Sbjct: 236 CVASNMAGERESAAAEVMVLE-RPSFLRRPVNQVVLADAPVTFLCEV-KGDPPPRLRW-R 292
Query: 186 NEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYV 241
ED P+ I +HSL + D YTCVA+N V R AS ++ V+V
Sbjct: 293 KEDGELPT--GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG-RAEASGSLSVHV 345
Score = 33.9 bits (76), Expect = 0.65
Identities = 32/98 (32%), Positives = 46/98 (46%), Gaps = 11/98 (11%)
Query: 153 QEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLV-----DPS----LDPNVYITRE 203
++P VS + LPCR EG P +EW +N V DP L P+ +
Sbjct: 68 EQPPDLLVSRGEPATLPCRA-EGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP 126
Query: 204 HSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYV 241
+ R+AR D YTCVA+N + S +A++ V V
Sbjct: 127 RIVHGRRAR-PDEGVYTCVARNYLGAAASRNASLEVAV 163
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 65.9 bits (159), Expect = 2e-10
Identities = 37/89 (41%), Positives = 49/89 (55%), Gaps = 5/89 (5%)
Query: 445 GTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPL--AGCQTLLSPI 502
G FN GG L TG+S++IP AIP G EIY + + + PL +TLLSP+
Sbjct: 1558 GIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPL 1617
Query: 503 VSCGPPGVLLTRPVILAMDHCGEPSPDSW 531
V CGP G+ +PV L + HC P +W
Sbjct: 1618 VMCGPHGLKFLKPVELRLPHC---DPKTW 1643
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 65.9 bits (159), Expect = 2e-10
Identities = 37/89 (41%), Positives = 49/89 (55%), Gaps = 5/89 (5%)
Query: 445 GTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPL--AGCQTLLSPI 502
G FN GG L TG+S++IP AIP G EIY + + + PL +TLLSP+
Sbjct: 1638 GIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPL 1697
Query: 503 VSCGPPGVLLTRPVILAMDHCGEPSPDSW 531
V CGP G+ +PV L + HC P +W
Sbjct: 1698 VMCGPHGLKFLKPVELRLPHC---DPKTW 1723
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/210 (27%), Positives = 98/210 (46%), Gaps = 17/210 (8%)
Query: 33 NPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKA---VPATQIFFKCNGEWVRQVDHVI 89
+P+PG F+ EP+DV + + PV+L C+A VP + K NG + + + I
Sbjct: 28 SPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLK-NGAKMSE-NKRI 85
Query: 90 ERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRK 149
E ++GS + +E R +E + QC+A + G SQKA++ ++ +
Sbjct: 86 EVLSNGSLYISEVEGRRGEQS---------DEGFYQCLAMNKYGAILSQKAHLALSTISA 136
Query: 150 NFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVR 209
FE +P++ EV E G+ PPA + W N + ++D + L +
Sbjct: 137 -FEVQPISTEVH-EGGVARFACKISSHPPAVITWEFNRTTLPMTMD-RITALPTGVLQIY 193
Query: 210 QARLADTANYTCVAKNIVARRRSASAAVIV 239
D+ NY C+A + RR+S A++ V
Sbjct: 194 DVSQRDSGNYRCIAATVAHRRKSMEASLTV 223
Score = 30.4 bits (67), Expect = 7.2
Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 3/52 (5%)
Query: 174 EGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKN 225
EGIP ++ WL+N + + +Y ++ LV+ Q D A Y C+A+N
Sbjct: 351 EGIPSPKMSWLKNGRKIHSNGRIKMYNSK---LVINQIIPEDDAIYQCMAEN 399
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 60.8 bits (146), Expect = 5e-09
Identities = 30/89 (33%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 209 RQARLADTANYTCVAKNIVARRRSASAA-VIVYVDGSWSPWSKWSACGLDC---THWRSR 264
++ R D + TC+ +I R S S + DG WS WS WS+C + C R R
Sbjct: 403 QRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
Query: 265 ECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
C+ P P+ GG+ C+G+ +T+ C C
Sbjct: 463 LCNSPVPQMGGKNCKGSGRETKACQGAPC 491
Score = 55.5 bits (132), Expect = 2e-07
Identities = 23/56 (41%), Positives = 31/56 (55%), Gaps = 3/56 (5%)
Query: 241 VDGSWSPWSKWSACGLDCT---HWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
+DG WSPWS WSAC + C R+R C+ P P+ GG+ C G + + C C
Sbjct: 493 IDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSC 548
Score = 41.6 bits (96), Expect = 0.003
Identities = 22/77 (28%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 220 TCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGE 276
TC + + V S V + WSPW++W+ C + C T R R C +
Sbjct: 359 TCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTS-----N 413
Query: 277 ECQGTDLDTRNCTSDLC 293
C G + TR C+ C
Sbjct: 414 TCLGPSIQTRACSLSKC 430
>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
Length = 1007
Score = 59.7 bits (143), Expect = 1e-08
Identities = 58/209 (27%), Positives = 88/209 (42%), Gaps = 14/209 (6%)
Query: 37 GANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVRQVD----HVIE 90
G D P LV P+D P + C+A P I + NG+ + V H++
Sbjct: 25 GMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLP 84
Query: 91 RSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKN 150
DG+ L R + Q L Y C+ A + GT S+ A + +A LR++
Sbjct: 85 ---DGTLLLLQPPARGHAHDGQALST-DLGVYTCE--ASNRLGTAVSRGARLSVAVLRED 138
Query: 151 FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQ 210
F+ +P + + L C PP G P V W + D +L P + SL++ +
Sbjct: 139 FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWK--DGKPLALQPGRHTVSGGSLLMAR 196
Query: 211 ARLADTANYTCVAKNIVARRRSASAAVIV 239
A +D Y CVA N R S +A V +
Sbjct: 197 AEKSDEGTYMCVATNSAGHRESRAARVSI 225
>gi|189242612 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 58.5 bits (140), Expect = 2e-08
Identities = 22/49 (44%), Positives = 29/49 (59%)
Query: 241 VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCT 289
VDG W WS WS C R+REC++PAP+ GG+ C+G +CT
Sbjct: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
>gi|169636415 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 58.5 bits (140), Expect = 2e-08
Identities = 22/49 (44%), Positives = 29/49 (59%)
Query: 241 VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCT 289
VDG W WS WS C R+REC++PAP+ GG+ C+G +CT
Sbjct: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 57.8 bits (138), Expect = 4e-08
Identities = 26/56 (46%), Positives = 35/56 (62%), Gaps = 5/56 (8%)
Query: 241 VDGSWSPWSKWSACGLDCT---HWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
VDG+W+ WS WSAC C+ R+REC+ P+ GG ECQG ++TR+C C
Sbjct: 466 VDGNWNEWSSWSACSASCSQGRQQRTRECNGPS--YGGAECQGHWVETRDCFLQQC 519
Score = 49.3 bits (116), Expect = 1e-05
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 210 QARLADTANYTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDCTH-WRSRECSD 268
+ R +++Y+ + +R + + + V G+W WS WS C C +R R +
Sbjct: 377 RTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTC 436
Query: 269 PAPRNGGEECQGTDLDTRNCTSDLC 293
P+ GG C+G + T+ C LC
Sbjct: 437 RPPQFGGNPCEGPEKQTKFCNIALC 461
Score = 45.4 bits (106), Expect = 2e-04
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 5/56 (8%)
Query: 241 VDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
VDG W W+ W +C + C + R R CS P GG CQG + R C + C
Sbjct: 521 VDGKWQAWASWGSCSVTCGAGSQRRERVCS--GPFFGGAACQGPQDEYRQCGTQRC 574
Score = 39.7 bits (91), Expect = 0.012
Identities = 20/54 (37%), Positives = 24/54 (44%), Gaps = 4/54 (7%)
Query: 243 GSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
G W WS W C DC R+R C PAP G C+G + R C + C
Sbjct: 262 GGWKLWSLWGECTRDCGGGLQTRTRTCL-PAPGVEGGGCEGVLEEGRQCNREAC 314
>gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
Length = 584
Score = 56.6 bits (135), Expect = 9e-08
Identities = 24/47 (51%), Positives = 28/47 (59%), Gaps = 1/47 (2%)
Query: 242 DGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNC 288
DGSWS WS WS C R REC +PAP+NGG C G + T+ C
Sbjct: 539 DGSWSCWSSWSVCRAGIQE-RRRECDNPAPQNGGASCPGRKVQTQAC 584
Score = 30.8 bits (68), Expect = 5.5
Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 4/74 (5%)
Query: 230 RRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCT 289
RR+A+ A + +WS W+ C +R R P + GG C G D +C+
Sbjct: 29 RRAATPAAVTCQLSNWSEWTDCFPC--QDKKYRHRSLLQP-NKFGGTICSGDIWDQASCS 85
Query: 290 SD-LCVHTASGPED 302
S CV A +D
Sbjct: 86 SSTTCVRQAQCGQD 99
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 55.8 bits (133), Expect = 2e-07
Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 3/62 (4%)
Query: 241 VDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTA 297
VDGSW+ W + C C R+C++P P NGG+ C+G + R+C + C +A
Sbjct: 515 VDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSA 574
Query: 298 SG 299
SG
Sbjct: 575 SG 576
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 55.5 bits (132), Expect = 2e-07
Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 207 VVRQARLADTANYTCVAKNIVARRRSASAAVIVYV-DGSWSPWSKWSACGLDC---THWR 262
+ ++ R D+ N C ++ R + DG WS WS WS+C + C R
Sbjct: 399 IQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITR 458
Query: 263 SRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
R C+ P+P+ G+ C+G +T+ C D C
Sbjct: 459 IRLCNSPSPQMNGKPCEGEARETKACKKDAC 489
Score = 52.8 bits (125), Expect = 1e-06
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 228 ARRRSASAAVIVYVDGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLD 284
AR A ++G W PWS W C + C RSR C++P P+ GG++C G +
Sbjct: 478 ARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTE 537
Query: 285 TRNCTSDLC 293
+ C C
Sbjct: 538 NQICNKQDC 546
Score = 42.0 bits (97), Expect = 0.002
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 8/55 (14%)
Query: 242 DGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
D WSPWS+W++C C R R C R C+G+ + TR C C
Sbjct: 379 DDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQEC 428
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 55.1 bits (131), Expect = 3e-07
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 3/54 (5%)
Query: 243 GSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
G W PW W C C + SR+C+ P PRNGG+ C+G R+C ++ C
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC 574
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 55.1 bits (131), Expect = 3e-07
Identities = 19/55 (34%), Positives = 35/55 (63%), Gaps = 3/55 (5%)
Query: 242 DGSWSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
DG+W W+K+ +C C +R+R+C++P P NGG++C G + + + C ++ C
Sbjct: 551 DGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 605
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 55.1 bits (131), Expect = 3e-07
Identities = 22/53 (41%), Positives = 30/53 (56%), Gaps = 3/53 (5%)
Query: 242 DGSWSPWSKWSACGLDCT---HWRSRECSDPAPRNGGEECQGTDLDTRNCTSD 291
+G+W+PWS W+ C C R R CS+PAPR+GG C G + R C +
Sbjct: 664 NGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNEN 716
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/56 (39%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 241 VDGSWSPWSKWSACGLDCT---HWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
V G W+ W WS+C DC R R C++P PRNGG C G + ++C C
Sbjct: 852 VSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQAC 907
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/56 (35%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Query: 241 VDGSWSPWSKWSACGLDCT---HWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
V G+WS W+ WS C C + R+R C+ PAP G + C G + C + C
Sbjct: 909 VRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQAC 964
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/87 (33%), Positives = 41/87 (47%), Gaps = 11/87 (12%)
Query: 209 RQARLADTANYTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACG-LDCTH-----WR 262
R + L D++N + +NI +A V DG + PWS W C LD + R
Sbjct: 581 RCSTLEDSSNMSLWTQNI-----TACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCR 635
Query: 263 SRECSDPAPRNGGEECQGTDLDTRNCT 289
+R C P PR GG +C G + NC+
Sbjct: 636 ARSCDSPRPRCGGLDCLGPAIHIANCS 662
Score = 43.1 bits (100), Expect = 0.001
Identities = 19/44 (43%), Positives = 22/44 (50%), Gaps = 2/44 (4%)
Query: 245 WSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNC 288
WSPWS+WS C D RSR C + P G C G +R C
Sbjct: 968 WSPWSEWSKCTDDGAQSRSRHCEELLP--GSSACAGNSSQSRPC 1009
Score = 32.0 bits (71), Expect = 2.5
Identities = 14/52 (26%), Positives = 21/52 (40%), Gaps = 9/52 (17%)
Query: 245 WSPWSKWSACGLDC---THWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
W+ W WS C +C R R C + G C G ++ + C + C
Sbjct: 725 WASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPEGC 770
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 54.7 bits (130), Expect = 4e-07
Identities = 22/54 (40%), Positives = 29/54 (53%), Gaps = 3/54 (5%)
Query: 242 DGSWSPWSKWSACGLDCT---HWRSRECSDPAPRNGGEECQGTDLDTRNCTSDL 292
+G W+PW+ WS C C R R CS+P PR+GG C G + + R C L
Sbjct: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHL 648
Score = 53.1 bits (126), Expect = 1e-06
Identities = 21/51 (41%), Positives = 30/51 (58%), Gaps = 3/51 (5%)
Query: 241 VDGSWSPWSKWSACGLDCTHW---RSRECSDPAPRNGGEECQGTDLDTRNC 288
V+G+WS W+ WS C DC+ R R C++P P+ GG C G L+ + C
Sbjct: 783 VNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQEC 833
Score = 53.1 bits (126), Expect = 1e-06
Identities = 23/56 (41%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 241 VDGSWSPWSKWSACGLDCT---HWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLC 293
VDG WS WS W+ C C + R+R CS+PAP GG+ C G + C + C
Sbjct: 840 VDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPC 895
Score = 44.7 bits (104), Expect = 4e-04
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 6/55 (10%)
Query: 241 VDGSWSPWSKWSAC------GLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCT 289
VDG + WS W+ C + R+R C PAP+ GG +C+G ++ NC+
Sbjct: 539 VDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCS 593
Score = 41.2 bits (95), Expect = 0.004
Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 15/107 (14%)
Query: 244 SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSD------LCVHTA 297
SWS WS WS C R+R+C P G +C G ++R C D + V +
Sbjct: 898 SWSEWSDWSECEASGVQVRARQCILLFPM--GSQCSGNTTESRPCVFDSNFIPEVSVARS 955
Query: 298 SGPEDVAL----YVGLIAVAV---CLVLLLLVLILVYCRKKEGLDSD 337
S E+ +IAV + L LL +L+ YC++ + D
Sbjct: 956 SSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHD 1002
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,475,508
Number of Sequences: 37866
Number of extensions: 1828260
Number of successful extensions: 5374
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 147
Number of HSP's that attempted gapping in prelim test: 4450
Number of HSP's gapped (non-prelim): 869
length of query: 842
length of database: 18,247,518
effective HSP length: 111
effective length of query: 731
effective length of database: 14,044,392
effective search space: 10266450552
effective search space used: 10266450552
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.