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Search of human proteins with 61676188
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61676188 HECT, UBA and WWE domain containing 1 [Homo
sapiens]
(4374 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 8596 0.0
gi|222352183 neural precursor cell expressed, developmentally do... 343 2e-93
gi|21361472 neural precursor cell expressed, developmentally dow... 343 2e-93
gi|222352094 neural precursor cell expressed, developmentally do... 343 2e-93
gi|222352092 neural precursor cell expressed, developmentally do... 343 2e-93
gi|222352090 neural precursor cell expressed, developmentally do... 343 2e-93
gi|222352088 neural precursor cell expressed, developmentally do... 343 2e-93
gi|222352086 neural precursor cell expressed, developmentally do... 343 2e-93
gi|222352084 neural precursor cell expressed, developmentally do... 343 2e-93
gi|222352082 neural precursor cell expressed, developmentally do... 343 2e-93
gi|114520609 neural precursor cell expressed, developmentally do... 339 3e-92
gi|114520607 neural precursor cell expressed, developmentally do... 339 3e-92
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 336 3e-91
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 332 4e-90
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 330 2e-89
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 330 2e-89
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 325 6e-88
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 321 9e-87
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 321 9e-87
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 310 3e-83
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 305 5e-82
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 305 6e-82
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 207 2e-52
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 204 2e-51
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 204 2e-51
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 204 2e-51
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 202 6e-51
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 189 7e-47
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 189 7e-47
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 188 1e-46
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 8596 bits (22305), Expect = 0.0
Identities = 4374/4374 (100%), Positives = 4374/4374 (100%)
Query: 1 MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR 60
MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR
Sbjct: 1 MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR 60
Query: 61 FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT 120
FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT
Sbjct: 61 FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT 120
Query: 121 TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA 180
TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA
Sbjct: 121 TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA 180
Query: 181 ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM 240
ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM
Sbjct: 181 ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM 240
Query: 241 ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI 300
ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI
Sbjct: 241 ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI 300
Query: 301 LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP 360
LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP
Sbjct: 301 LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP 360
Query: 361 VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG 420
VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG
Sbjct: 361 VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG 420
Query: 421 DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ 480
DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ
Sbjct: 421 DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ 480
Query: 481 RPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL 540
RPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL
Sbjct: 481 RPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL 540
Query: 541 KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV 600
KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV
Sbjct: 541 KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV 600
Query: 601 LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG 660
LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG
Sbjct: 601 LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG 660
Query: 661 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH 720
SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH
Sbjct: 661 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH 720
Query: 721 AAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI 780
AAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI
Sbjct: 721 AAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI 780
Query: 781 LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV 840
LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV
Sbjct: 781 LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV 840
Query: 841 LQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH 900
LQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH
Sbjct: 841 LQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH 900
Query: 901 AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL 960
AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL
Sbjct: 901 AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL 960
Query: 961 PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA 1020
PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA
Sbjct: 961 PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA 1020
Query: 1021 PMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR 1080
PMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR
Sbjct: 1021 PMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR 1080
Query: 1081 QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP 1140
QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP
Sbjct: 1081 QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP 1140
Query: 1141 MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD 1200
MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD
Sbjct: 1141 MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD 1200
Query: 1201 AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRK 1260
AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRK
Sbjct: 1201 AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRK 1260
Query: 1261 PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ 1320
PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ
Sbjct: 1261 PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ 1320
Query: 1321 QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIA 1380
QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIA
Sbjct: 1321 QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIA 1380
Query: 1381 MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT 1440
MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT
Sbjct: 1381 MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT 1440
Query: 1441 DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL 1500
DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL
Sbjct: 1441 DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL 1500
Query: 1501 PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL 1560
PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL
Sbjct: 1501 PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL 1560
Query: 1561 LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF 1620
LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF
Sbjct: 1561 LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF 1620
Query: 1621 DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML 1680
DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML
Sbjct: 1621 DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML 1680
Query: 1681 TLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEET 1740
TLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEET
Sbjct: 1681 TLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEET 1740
Query: 1741 KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS 1800
KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS
Sbjct: 1741 KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS 1800
Query: 1801 TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG 1860
TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG
Sbjct: 1801 TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG 1860
Query: 1861 SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN 1920
SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN
Sbjct: 1861 SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN 1920
Query: 1921 AVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLL 1980
AVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLL
Sbjct: 1921 AVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLL 1980
Query: 1981 QDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESR 2040
QDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESR
Sbjct: 1981 QDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESR 2040
Query: 2041 DGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE 2100
DGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE
Sbjct: 2041 DGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE 2100
Query: 2101 LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL 2160
LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL
Sbjct: 2101 LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL 2160
Query: 2161 GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG 2220
GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG
Sbjct: 2161 GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG 2220
Query: 2221 LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ 2280
LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ
Sbjct: 2221 LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ 2280
Query: 2281 GASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ 2340
GASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ
Sbjct: 2281 GASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ 2340
Query: 2341 EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR 2400
EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR
Sbjct: 2341 EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR 2400
Query: 2401 EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD 2460
EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD
Sbjct: 2401 EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD 2460
Query: 2461 DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV 2520
DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV
Sbjct: 2461 DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV 2520
Query: 2521 RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL 2580
RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL
Sbjct: 2521 RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL 2580
Query: 2581 LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT 2640
LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT
Sbjct: 2581 LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT 2640
Query: 2641 LSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEE 2700
LSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEE
Sbjct: 2641 LSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEE 2700
Query: 2701 ETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKE 2760
ETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKE
Sbjct: 2701 ETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKE 2760
Query: 2761 TLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAET 2820
TLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAET
Sbjct: 2761 TLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAET 2820
Query: 2821 TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSS 2880
TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSS
Sbjct: 2821 TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSS 2880
Query: 2881 EQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADS 2940
EQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADS
Sbjct: 2881 EQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADS 2940
Query: 2941 RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS 3000
RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS
Sbjct: 2941 RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS 3000
Query: 3001 TNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT 3060
TNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT
Sbjct: 3001 TNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT 3060
Query: 3061 FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA 3120
FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA
Sbjct: 3061 FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA 3120
Query: 3121 LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL 3180
LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL
Sbjct: 3121 LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL 3180
Query: 3181 LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI 3240
LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI
Sbjct: 3181 LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI 3240
Query: 3241 ETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI 3300
ETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI
Sbjct: 3241 ETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI 3300
Query: 3301 FQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN 3360
FQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN
Sbjct: 3301 FQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN 3360
Query: 3361 CESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGE 3420
CESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGE
Sbjct: 3361 CESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGE 3420
Query: 3421 TSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGA 3480
TSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGA
Sbjct: 3421 TSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGA 3480
Query: 3481 SSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTA 3540
SSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTA
Sbjct: 3481 SSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTA 3540
Query: 3541 TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED 3600
TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED
Sbjct: 3541 TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED 3600
Query: 3601 AANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCET 3660
AANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCET
Sbjct: 3601 AANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCET 3660
Query: 3661 LSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQ 3720
LSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQ
Sbjct: 3661 LSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQ 3720
Query: 3721 KFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVR 3780
KFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVR
Sbjct: 3721 KFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVR 3780
Query: 3781 EGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEER 3840
EGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEER
Sbjct: 3781 EGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEER 3840
Query: 3841 PPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV 3900
PPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV
Sbjct: 3841 PPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV 3900
Query: 3901 RDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE 3960
RDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE
Sbjct: 3901 RDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE 3960
Query: 3961 THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVH 4020
THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVH
Sbjct: 3961 THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVH 4020
Query: 4021 VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL 4080
VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL
Sbjct: 4021 VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL 4080
Query: 4081 FRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS 4140
FRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS
Sbjct: 4081 FRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS 4140
Query: 4141 VRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTE 4200
VRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTE
Sbjct: 4141 VRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTE 4200
Query: 4201 ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDID 4260
ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDID
Sbjct: 4201 ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDID 4260
Query: 4261 DLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI 4320
DLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI
Sbjct: 4261 DLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI 4320
Query: 4321 QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA
Sbjct: 4321 QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 475 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 532
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 533 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 592
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 593 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 650
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 829
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 830 YETFEDLREKLLMAV-ENAQGF 850
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 576 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 633
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 634 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 693
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 694 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 751
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 752 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 811
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 812 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 871
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 872 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 930
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 931 YETFEDLREKLLMAV-ENAQGF 951
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 455 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 512
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 513 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 572
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 573 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 630
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 631 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 690
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 691 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 750
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 751 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 809
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 810 YETFEDLREKLLMAV-ENAQGF 830
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 455 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 512
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 513 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 572
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 573 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 630
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 631 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 690
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 691 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 750
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 751 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 809
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 810 YETFEDLREKLLMAV-ENAQGF 830
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 568 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 625
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 626 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 685
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 686 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 743
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 744 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 803
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 804 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 863
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 864 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 922
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 923 YETFEDLREKLLMAV-ENAQGF 943
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 588 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 645
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 646 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 705
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 706 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 763
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 764 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 823
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 824 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 883
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 884 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 942
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 943 YETFEDLREKLLMAV-ENAQGF 963
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 596 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 653
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 654 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 713
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 714 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 771
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 772 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 831
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 832 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 891
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 892 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 950
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 951 YETFEDLREKLLMAV-ENAQGF 971
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 475 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 532
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 533 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 592
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 593 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 650
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 829
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 830 YETFEDLREKLLMAV-ENAQGF 850
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 343 bits (880), Expect = 2e-93
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 475 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 532
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 533 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 592
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 593 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 650
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 829
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YE+FE LR LL+A+ E ++GF
Sbjct: 830 YETFEDLREKLLMAV-ENAQGF 850
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 339 bits (870), Expect = 3e-92
Identities = 186/382 (48%), Positives = 254/382 (66%), Gaps = 11/382 (2%)
Query: 3995 DVKRKY--FRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
D KRKY FR++L++ ++ K +M + RR V EDSYR + K + +K RL+I F+
Sbjct: 521 DYKRKYEFFRRKLKKQNDIPNKFEMKL--RRATVLEDSYRRIMGVKRADFLKARLWIEFD 578
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
GE+G D GG+ REW+ +IS+EMFNP Y LF S D T INP+S CN +HLSYFKF+
Sbjct: 579 GEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFI 638
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AVY +LL+ +F R FYK +L K + DMES D +Y L ++LEND + L
Sbjct: 639 GRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL-- 696
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG +LK G+ I+VT +NKKEY++LV Q R I+KQ+AAF EGF
Sbjct: 697 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 756
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
+E+IP+ LI IF E ELELL+ GL +D++D + +T+Y + Y +N IQWFW+A+ D
Sbjct: 757 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 816
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F + + + ++LP AHTCFN+LDLP
Sbjct: 817 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAHTCFNRLDLPP 875
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YESFE+L L +AI E ++GF
Sbjct: 876 YESFEELWDKLQMAI-ENTQGF 896
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 339 bits (870), Expect = 3e-92
Identities = 186/382 (48%), Positives = 254/382 (66%), Gaps = 11/382 (2%)
Query: 3995 DVKRKY--FRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
D KRKY FR++L++ ++ K +M + RR V EDSYR + K + +K RL+I F+
Sbjct: 868 DYKRKYEFFRRKLKKQNDIPNKFEMKL--RRATVLEDSYRRIMGVKRADFLKARLWIEFD 925
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
GE+G D GG+ REW+ +IS+EMFNP Y LF S D T INP+S CN +HLSYFKF+
Sbjct: 926 GEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFI 985
Query: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
GR+ AVY +LL+ +F R FYK +L K + DMES D +Y L ++LEND + L
Sbjct: 986 GRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL-- 1043
Query: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
DL F + + FG +LK G+ I+VT +NKKEY++LV Q R I+KQ+AAF EGF
Sbjct: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
Query: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
+E+IP+ LI IF E ELELL+ GL +D++D + +T+Y + Y +N IQWFW+A+ D
Sbjct: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
Query: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
R + LQFVTGTS+VP+ GFA L G NG Q F + + + ++LP AHTCFN+LDLP
Sbjct: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAHTCFNRLDLPP 1222
Query: 4350 YESFEKLRHMLLLAIQECSEGF 4371
YESFE+L L +AI E ++GF
Sbjct: 1223 YESFEELWDKLQMAI-ENTQGF 1243
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 336 bits (862), Expect = 3e-91
Identities = 168/402 (41%), Positives = 257/402 (63%), Gaps = 10/402 (2%)
Query: 3971 RQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDS 4030
R + L +GP + Y+R DF K +YFR ++L + + + V R +FEDS
Sbjct: 469 RTGKSALDNGP---QIAYVR--DFKAKVQYFRFWCQQL---AMPQHIKITVTRKTLFEDS 520
Query: 4031 YRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVT 4090
++++ SP++++ RL+++F GEEG D GG+ REW+ ++S E+ NPMY LF + D
Sbjct: 521 FQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYC 580
Query: 4091 YTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESED 4150
INP+S+ NP+HL YF+F+GR +A A++ + ++ F+ FYK IL K V D+ES D
Sbjct: 581 LQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESID 640
Query: 4151 YHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLV 4210
FY L+++ EN++ ++ FS + + G + DLKPNG NILVTEENK+EY+ +V
Sbjct: 641 PEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMV 700
Query: 4211 CQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK 4270
+ R++ + +Q AF EGF EI+P++ + F +ELE+L+ G+ ID++D + + Y
Sbjct: 701 AEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH 760
Query: 4271 YQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDR 4330
Y S QI WFW+ ++ D R + LQFVTGT ++P+ GFA L G NG QKF I + +
Sbjct: 761 YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGK 820
Query: 4331 STDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
+ LP +HTCFN+LDLP Y+S+E+L+ LL AI+E +EGFG
Sbjct: 821 E-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 860
Score = 33.1 bits (74), Expect = 6.2
Identities = 24/94 (25%), Positives = 41/94 (43%), Gaps = 1/94 (1%)
Query: 3470 SEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTS-APALVAATAISTIVV 3528
S+ ++G+G + + ++ S + + P P+ P P T PA V + +T
Sbjct: 180 SDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSES 239
Query: 3529 AASTTVTTPTTATTTVSISPTTKGSKSPAKVSDG 3562
S+T + P T T T + T G P +S G
Sbjct: 240 DGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGG 273
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 332 bits (852), Expect = 4e-90
Identities = 175/374 (46%), Positives = 232/374 (62%), Gaps = 3/374 (0%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEG 4052
D K K RQEL + + + V R+ +FE+SYR++ + P+++ RL I F G
Sbjct: 371 DLVQKLKILRQELSQQQP--QAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRG 428
Query: 4053 EEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 4112
EEG D GG+ REW ++S EM NP Y LF+ S D T INP S NP HLSYF FVGR
Sbjct: 429 EEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGR 488
Query: 4113 IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDL 4172
I+ AV+ ++ FT FYK +LGKS+ DME D + LV++LEND++ + D
Sbjct: 489 IMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV-LDH 547
Query: 4173 TFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYE 4232
TF E +G +LKPNG +I V EENKKEYV L R I Q A +GF E
Sbjct: 548 TFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNE 607
Query: 4233 IIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQAD 4292
+IP+ L+ F E+ELEL+I GL ID++D K NT +S ++WFW+A+ FD+
Sbjct: 608 VIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEER 667
Query: 4293 RAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYES 4352
RA+ LQFVTG+S+VPLQGF AL+G G + F IH+ D T+ LP AHTCFN++D+P YES
Sbjct: 668 RARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYES 727
Query: 4353 FEKLRHMLLLAIQE 4366
+EKL LL AI+E
Sbjct: 728 YEKLYEKLLTAIEE 741
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 330 bits (846), Expect = 2e-89
Identities = 165/351 (47%), Positives = 229/351 (65%), Gaps = 4/351 (1%)
Query: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
+ V R+ +FE+SYR++ + P+++K RL + F GEEG D GG+ REW ++ EM NP Y
Sbjct: 401 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 460
Query: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
LF+ S + INP S NP+HLSYF FVGRI+ AV+ + FT FYK +LG
Sbjct: 461 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 520
Query: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
K ++ +D+ES D ++ LV++LEND++ + D TF E FG +LKPNG N+ V
Sbjct: 521 KPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPV 579
Query: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
TEENKKEYV L R I Q A +GF E+IP+ L+ F ++ELEL+I GL ID
Sbjct: 580 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 639
Query: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
++D KSNT ++S ++WFW+A+ +FD+ RA+ LQFVTG+++VPLQGF AL+G
Sbjct: 640 LNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGST 699
Query: 4319 GI---QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQE 4366
G + F IH D +TD LP AHTCFN++D+P YES+EKL LL A++E
Sbjct: 700 GAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 750
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 330 bits (846), Expect = 2e-89
Identities = 165/351 (47%), Positives = 229/351 (65%), Gaps = 4/351 (1%)
Query: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
+ V R+ +FE+SYR++ + P+++K RL + F GEEG D GG+ REW ++ EM NP Y
Sbjct: 375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 434
Query: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
LF+ S + INP S NP+HLSYF FVGRI+ AV+ + FT FYK +LG
Sbjct: 435 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 494
Query: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
K ++ +D+ES D ++ LV++LEND++ + D TF E FG +LKPNG N+ V
Sbjct: 495 KPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPV 553
Query: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
TEENKKEYV L R I Q A +GF E+IP+ L+ F ++ELEL+I GL ID
Sbjct: 554 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 613
Query: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
++D KSNT ++S ++WFW+A+ +FD+ RA+ LQFVTG+++VPLQGF AL+G
Sbjct: 614 LNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGST 673
Query: 4319 GI---QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQE 4366
G + F IH D +TD LP AHTCFN++D+P YES+EKL LL A++E
Sbjct: 674 GAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 724
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 325 bits (833), Expect = 6e-88
Identities = 155/354 (43%), Positives = 234/354 (66%), Gaps = 2/354 (0%)
Query: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
++V R +FEDS++++ P +++ RLY++F GEEG D GGL REW+ ++S E+ NPMY
Sbjct: 569 INVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMY 628
Query: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
LF + + INP+S NP+HLSYF F+GR +A A++ + ++ F+ FYK +L
Sbjct: 629 CLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLS 688
Query: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
K + D+ES D FY L+++ +N++ G ++ FS +++ G DLK G+NILV
Sbjct: 689 KKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILV 748
Query: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
TEENK EY+ L+ + R + +++Q AFL+GF E++P + + F E+ELE+++ G+ +D
Sbjct: 749 TEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVD 808
Query: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
+ D + NT Y Y NS QI WFW+ ++ D R + LQFVTGT ++PL GFA L G N
Sbjct: 809 LADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSN 868
Query: 4319 GIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
G QKF I + + T LP +HTCFN+LDLP Y+S+E+L+ LL AI+E +EGFG
Sbjct: 869 GPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 920
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 321 bits (823), Expect = 9e-87
Identities = 156/354 (44%), Positives = 227/354 (64%), Gaps = 2/354 (0%)
Query: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
+ V R +FEDS++++ P +++ RLYI+ GEEG D GG+ REW+ ++S E+ NPMY
Sbjct: 78 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 137
Query: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
LF + + INP+S NP+HL+YF+F+GR +A A+Y + ++ FT FYK +L
Sbjct: 138 CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLN 197
Query: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
K D+ES D FY +V++ EN++ G +L F +++ G +LK G +I V
Sbjct: 198 KRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRV 257
Query: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
TEENK+EY+ L+ R T + +Q AFL+GF E+ P + F E+ELEL++ G+ ID
Sbjct: 258 TEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEID 317
Query: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
+ D + +T Y Y NS QIQWFW+ ++ D R + LQFVTGT ++P+ GFA L G N
Sbjct: 318 MSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 377
Query: 4319 GIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
G QKF I + + T LP +HTCFN+LDLP Y+S+E+LR LL AI+E +EGFG
Sbjct: 378 GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEE-TEGFG 429
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 321 bits (823), Expect = 9e-87
Identities = 156/354 (44%), Positives = 227/354 (64%), Gaps = 2/354 (0%)
Query: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
+ V R +FEDS++++ P +++ RLYI+ GEEG D GG+ REW+ ++S E+ NPMY
Sbjct: 517 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 576
Query: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
LF + + INP+S NP+HL+YF+F+GR +A A+Y + ++ FT FYK +L
Sbjct: 577 CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLN 636
Query: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
K D+ES D FY +V++ EN++ G +L F +++ G +LK G +I V
Sbjct: 637 KRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRV 696
Query: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
TEENK+EY+ L+ R T + +Q AFL+GF E+ P + F E+ELEL++ G+ ID
Sbjct: 697 TEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEID 756
Query: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
+ D + +T Y Y NS QIQWFW+ ++ D R + LQFVTGT ++P+ GFA L G N
Sbjct: 757 MSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 816
Query: 4319 GIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
G QKF I + + T LP +HTCFN+LDLP Y+S+E+LR LL AI+E +EGFG
Sbjct: 817 GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEE-TEGFG 868
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 310 bits (793), Expect = 3e-83
Identities = 163/383 (42%), Positives = 239/383 (62%), Gaps = 5/383 (1%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEM-KNRLYIVFE 4051
DF+ K + F ++LE G + + +RRDH+ ED++ ++ S +++ +N+LY+ F
Sbjct: 1192 DFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFV 1251
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVG 4111
GEEG D G RE++ ++SRE+FNP Y LF S D T I+P S NH +F+F G
Sbjct: 1252 GEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSG 1311
Query: 4112 RIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYD 4171
RI+ A+ LL+ +FTR FYK +L +D+E D F+Q L ++ +ND+ + D
Sbjct: 1312 RILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI-LD 1370
Query: 4172 LTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFY 4231
LTF+ + FG R+LKP GANI VTE+NKKEY+ + + R+ + +Q + + GFY
Sbjct: 1371 LTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFY 1430
Query: 4232 EIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQ 4290
E++ RL+S+F +ELEL+I+G ID+ D ++NTEY Y N I I+WFW A+ F+
Sbjct: 1431 EVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNN 1490
Query: 4291 ADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAY 4350
R + LQFVTGTS +P +GFA+L G NG ++F + + + T LP AHTCFN+LDLP Y
Sbjct: 1491 EQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPY 1549
Query: 4351 ESFEKLRHMLLLAIQECSEGFGL 4373
SF L LL A++E S FGL
Sbjct: 1550 PSFSMLYEKLLTAVEETST-FGL 1571
Score = 38.5 bits (88), Expect = 0.15
Identities = 64/270 (23%), Positives = 101/270 (37%), Gaps = 40/270 (14%)
Query: 2730 TEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGE----VPQ 2785
+E+++ + S+PT +S E + + Q L P +L E +
Sbjct: 437 SERSMGASPKLRSSFPTDTRLNAMLHIDSDE-----EDHEFQQDLGYPSSLEEEGGLIMF 491
Query: 2786 ELQSPAGEGGSSTQLLM---PVEPEELGP-------TRPSGEAETTQMEL--SPAPTITS 2833
S A +G ++Q + PVE EE +P E + L PAP
Sbjct: 492 SRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESSLPAGPAPEEGE 551
Query: 2834 LSPERAEDSDALTA-------VSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAG 2886
PE +D +A V G+ TS AS AV +T + +P
Sbjct: 552 GGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSD-ASGGSRRAVSETESLDQGSEPSQV 610
Query: 2887 SSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSR-GILE 2945
SS + PA R++ E++ PE S ++SS +S D+R LE
Sbjct: 611 SSETEPSDPA------RTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLE 664
Query: 2946 E----PLPSTSSEEEDPLAGISLPEGVDPS 2971
P+ SS+EE+ A + P P+
Sbjct: 665 SARFPETPAFSSQEEEDGACAAEPTSSGPA 694
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 305 bits (782), Expect = 5e-82
Identities = 183/455 (40%), Positives = 258/455 (56%), Gaps = 28/455 (6%)
Query: 3942 MHISSSLPPD--TQKFLRFAETHRTVLNQILRQSTTHLADGPFAVL---------VDYIR 3990
M S +PP + +F+ F H VL + ++ + D +L + I+
Sbjct: 461 MCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIK 520
Query: 3991 VLDFDVKRKYFRQELERLDEGLRKEDMAVH----------VRRDHVFEDSYRELHRKSPE 4040
F + ++F E L G DM VH V RD +F S + + +
Sbjct: 521 AQPFKDRCEWF---YEHLHSGQPDSDM-VHRPVNENDILLVHRDSIFRSSCEVVSKANCA 576
Query: 4041 EMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCN 4100
++K + + F GEEG G ++REW+ I+S E+ NP YALF T D T+ N +S+ N
Sbjct: 577 KLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYALF-TQSADGTTFQPNSNSYVN 634
Query: 4101 PNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL 4160
P+HL+YF+F G+I+ A+ +L+ YFTRSFYKHILG V Y D+ S D + + L ++
Sbjct: 635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI 694
Query: 4161 LENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIR 4220
L+ND+S LG +LTFS E FG E LKP G +ILVT+ NK EYV LV ++RMT AI+
Sbjct: 695 LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQ 754
Query: 4221 KQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQ 4279
Q+ AFL+GF+ IP LI +F E ELELL+SG+P ID+ D NTEY Y+ IQ
Sbjct: 755 PQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQ 814
Query: 4280 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAH 4339
WFW + Q +R LQFVTG+S+VP GFA + G +G+Q F I + + LP++
Sbjct: 815 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSS 874
Query: 4340 TCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
TC N L LP Y S E L+ LL+A+ S G+ +A
Sbjct: 875 TCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 909
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 305 bits (781), Expect = 6e-82
Identities = 161/383 (42%), Positives = 239/383 (62%), Gaps = 5/383 (1%)
Query: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEM-KNRLYIVFE 4051
DF+ K + F ++LE G + + +RRDH+ E ++ ++ S +E+ +N+LY+ F
Sbjct: 1226 DFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFV 1285
Query: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVG 4111
GEEG D G RE++ ++S+E+FNP Y LF S D T I+P S NHL +F+F G
Sbjct: 1286 GEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSG 1345
Query: 4112 RIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYD 4171
RI+ A+ LL+ +FTR FYK +L +D+E D F+Q L ++ +N+++ + D
Sbjct: 1346 RILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LD 1404
Query: 4172 LTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFY 4231
LTF+ + FG R+LK GAN VTE+NKKEY+ + + R+ + +Q A + GFY
Sbjct: 1405 LTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFY 1464
Query: 4232 EIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQ 4290
E++ RL+S+F +ELEL+I+G ID++D ++NTEY Y + I+WFW A+ F+
Sbjct: 1465 EVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNN 1524
Query: 4291 ADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAY 4350
R + LQFVTGTS VP +GFAAL G NG+++F I + + T LP AHTCFN+LDLP Y
Sbjct: 1525 EQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPY 1583
Query: 4351 ESFEKLRHMLLLAIQECSEGFGL 4373
S+ L LL A++E S FGL
Sbjct: 1584 PSYSMLYEKLLTAVEETST-FGL 1605
Score = 40.0 bits (92), Expect = 0.051
Identities = 41/174 (23%), Positives = 68/174 (39%), Gaps = 21/174 (12%)
Query: 2284 QDSSSN---QQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ 2340
QDS N + GEP +E E ++ +G + DG +Q
Sbjct: 365 QDSPMNNLMESGSGEP-RSEAPESSESWKPEQLGEGSVPDGPG---------------NQ 408
Query: 2341 EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR 2400
+++ E+ ++ G G ++ +GE +Q + APS A L
Sbjct: 409 SIELSRPAEEAA--VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGE 466
Query: 2401 EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEG 2454
E S +L+ + T+EE + + EEEE+E++EE D E EG
Sbjct: 467 EASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEG 520
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 207 bits (527), Expect = 2e-52
Identities = 135/395 (34%), Positives = 210/395 (53%), Gaps = 26/395 (6%)
Query: 3994 FDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGE 4053
F K +F++EL ++ + + V R + E S + S + +VF+ E
Sbjct: 439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDE 498
Query: 4054 EGQDAGGLLREWYMIISREMFNPMYALF-RTSPGDRVTYTINPSSHCNPNHL--SYFKFV 4110
E D GG REW+ +I + +F+ LF R S ++ NP+ P HL ++F
Sbjct: 499 EALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFA 555
Query: 4111 GRIVAKAVYDNRLLECY-------FTRSFYKHILGKSVRYTDMESEDYHFYQGLV-YLLE 4162
GR+V K +Y++ L Y FTRSF I+G + Y E++D FY+ V ++L
Sbjct: 556 GRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILN 615
Query: 4163 NDVSTLGYDLTFSTEVQEFG--VCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIR 4220
ND+S + +L F+ E + +V +L GA VT NK Y++L+ Q R+ ++
Sbjct: 616 NDMSEM--ELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVK 673
Query: 4221 KQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY--HKYQSNSIQI 4278
+++ FL+G E++P+ L++IF E ELELL+ G I + D K++ + +
Sbjct: 674 EEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVM 733
Query: 4279 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 4338
+WFW + S Q + A+ LQF TG+S++P GFAAL FQI + LP+A
Sbjct: 734 RWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAAL-----CPSFQIIAAP-THSTLPTA 787
Query: 4339 HTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGL 4373
HTCFNQL LP Y+S+E++ ML LAI E EGFG+
Sbjct: 788 HTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 204 bits (518), Expect = 2e-51
Identities = 124/365 (33%), Positives = 199/365 (54%), Gaps = 21/365 (5%)
Query: 4017 MAVHVRRDHVFEDSYRELHR---KSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREM 4073
+ + VRRDH+ +D+ L ++P ++K +LY+ FEGE+G D GG+ +E++ ++ E+
Sbjct: 520 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 579
Query: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133
FNP +F ++ + NPSS F +G ++ A+Y+N +L+ +F Y
Sbjct: 580 FNPDIGMFTYDESTKL-FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 635
Query: 4134 KHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE---FGVCEVRDLK 4190
+ ++GK + D+ YQ L LLE + + D+ + ++ + FG + DLK
Sbjct: 636 RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE-GNVEDDMMITFQISQTDLFGNPMMYDLK 694
Query: 4191 PNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKR-LISIFTEQELEL 4249
NG I +T EN+KE+V+L + ++ KQ AF GF+ + + L +F +E+EL
Sbjct: 695 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 754
Query: 4250 LISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 4308
LI G +D L+ TEY Y +S+ I+ FW + SF + FLQF TGT + P+
Sbjct: 755 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 814
Query: 4309 QGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECS 4368
G L K I ++ T+RLP++HTCFN L LP Y S EKL+ LL AI +
Sbjct: 815 GGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYA 866
Query: 4369 EGFGL 4373
+GFG+
Sbjct: 867 KGFGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 204 bits (518), Expect = 2e-51
Identities = 124/365 (33%), Positives = 199/365 (54%), Gaps = 21/365 (5%)
Query: 4017 MAVHVRRDHVFEDSYRELHR---KSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREM 4073
+ + VRRDH+ +D+ L ++P ++K +LY+ FEGE+G D GG+ +E++ ++ E+
Sbjct: 500 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 559
Query: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133
FNP +F ++ + NPSS F +G ++ A+Y+N +L+ +F Y
Sbjct: 560 FNPDIGMFTYDESTKL-FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 615
Query: 4134 KHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE---FGVCEVRDLK 4190
+ ++GK + D+ YQ L LLE + + D+ + ++ + FG + DLK
Sbjct: 616 RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE-GNVEDDMMITFQISQTDLFGNPMMYDLK 674
Query: 4191 PNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKR-LISIFTEQELEL 4249
NG I +T EN+KE+V+L + ++ KQ AF GF+ + + L +F +E+EL
Sbjct: 675 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 734
Query: 4250 LISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 4308
LI G +D L+ TEY Y +S+ I+ FW + SF + FLQF TGT + P+
Sbjct: 735 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 794
Query: 4309 QGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECS 4368
G L K I ++ T+RLP++HTCFN L LP Y S EKL+ LL AI +
Sbjct: 795 GGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYA 846
Query: 4369 EGFGL 4373
+GFG+
Sbjct: 847 KGFGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 204 bits (518), Expect = 2e-51
Identities = 124/365 (33%), Positives = 199/365 (54%), Gaps = 21/365 (5%)
Query: 4017 MAVHVRRDHVFEDSYRELHR---KSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREM 4073
+ + VRRDH+ +D+ L ++P ++K +LY+ FEGE+G D GG+ +E++ ++ E+
Sbjct: 523 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 582
Query: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133
FNP +F ++ + NPSS F +G ++ A+Y+N +L+ +F Y
Sbjct: 583 FNPDIGMFTYDESTKL-FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 638
Query: 4134 KHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE---FGVCEVRDLK 4190
+ ++GK + D+ YQ L LLE + + D+ + ++ + FG + DLK
Sbjct: 639 RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE-GNVEDDMMITFQISQTDLFGNPMMYDLK 697
Query: 4191 PNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKR-LISIFTEQELEL 4249
NG I +T EN+KE+V+L + ++ KQ AF GF+ + + L +F +E+EL
Sbjct: 698 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
Query: 4250 LISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 4308
LI G +D L+ TEY Y +S+ I+ FW + SF + FLQF TGT + P+
Sbjct: 758 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 817
Query: 4309 QGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECS 4368
G L K I ++ T+RLP++HTCFN L LP Y S EKL+ LL AI +
Sbjct: 818 GGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYA 869
Query: 4369 EGFGL 4373
+GFG+
Sbjct: 870 KGFGM 874
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 202 bits (514), Expect = 6e-51
Identities = 129/375 (34%), Positives = 197/375 (52%), Gaps = 42/375 (11%)
Query: 4021 VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL 4080
VRR H+ DS EL RK + +K +L + F GE G D GGL +EW++++ R++F+P Y +
Sbjct: 421 VRRTHLVSDSLDELTRKRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGM 479
Query: 4081 FRTSPGDRVTYTINPSSHCN------PNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYK 4134
F T + SHC+ ++ S F+ VG ++ AVY++ L+ F YK
Sbjct: 480 F----------TYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYK 529
Query: 4135 HILGKSVRYTDMES---------EDY-----HFYQGLVYLL--ENDVSTLGYDLTFSTEV 4178
+L + +D +D GL LL E +V Y TF
Sbjct: 530 KLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYS-TFQVFQ 588
Query: 4179 QEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRL 4238
+EFG+ + +LKP G I VT +N+KEYV L + +I KQ AAF GF+ +
Sbjct: 589 EEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNA 648
Query: 4239 ISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQ 4298
+ + +E+E+L+ G P +D+ L+ +T+Y Y + I++FW + F + K L
Sbjct: 649 LMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLH 708
Query: 4299 FVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRH 4358
F TG+ +VP+ G A L F+I +++ ST+ LP AHTCFNQL LP Y+S + L+
Sbjct: 709 FTTGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761
Query: 4359 MLLLAIQECSEGFGL 4373
L++ I SEGFGL
Sbjct: 762 KLIIGISN-SEGFGL 775
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 189 bits (479), Expect = 7e-47
Identities = 134/390 (34%), Positives = 200/390 (51%), Gaps = 38/390 (9%)
Query: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEG-----EEGQDAGGLLREWYMIISREM 4073
+ +RR + ED Y +L + S MK + + F E G D G+ +E+ I + +
Sbjct: 683 ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
Query: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133
F+P LF+T+ GD Y +P+S+ + N+L F+FVG+++ KAVY+ +++ F F
Sbjct: 743 FDPALNLFKTTSGDERLYP-SPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFL 801
Query: 4134 KHILGK--SVRYTDME---SEDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEV 4186
+LG SV Y+ ++ S D FY+ L + + D++ LG L++ +V VC
Sbjct: 802 SQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCH- 860
Query: 4187 RDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQE 4246
+L P G I VT ENK Y+HL+ RM I+ Q AA + GF II I +F+ E
Sbjct: 861 -ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPE 919
Query: 4247 LELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRS-FDQADRAKFLQFVTGT 4303
L+ LISG ID++DLK +T Y+ + + I W W L S F +RA FL+FVT
Sbjct: 920 LQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSC 979
Query: 4304 SKVPLQGFAALEGMNGIQKFQIHRDDRSTD-------------------RLPSAHTCFNQ 4344
S+ PL GFA L+ I+ ++ D + D RLP++ TCFN
Sbjct: 980 SRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNL 1039
Query: 4345 LDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
L LP Y LR L AI + GF L+
Sbjct: 1040 LKLPNYSKKSVLREKLRYAI-SMNTGFELS 1068
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 189 bits (479), Expect = 7e-47
Identities = 134/390 (34%), Positives = 200/390 (51%), Gaps = 38/390 (9%)
Query: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEG-----EEGQDAGGLLREWYMIISREM 4073
+ +RR + ED Y +L + S MK + + F E G D G+ +E+ I + +
Sbjct: 683 ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
Query: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133
F+P LF+T+ GD Y +P+S+ + N+L F+FVG+++ KAVY+ +++ F F
Sbjct: 743 FDPALNLFKTTSGDERLYP-SPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFL 801
Query: 4134 KHILGK--SVRYTDME---SEDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEV 4186
+LG SV Y+ ++ S D FY+ L + + D++ LG L++ +V VC
Sbjct: 802 SQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCH- 860
Query: 4187 RDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQE 4246
+L P G I VT ENK Y+HL+ RM I+ Q AA + GF II I +F+ E
Sbjct: 861 -ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPE 919
Query: 4247 LELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRS-FDQADRAKFLQFVTGT 4303
L+ LISG ID++DLK +T Y+ + + I W W L S F +RA FL+FVT
Sbjct: 920 LQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSC 979
Query: 4304 SKVPLQGFAALEGMNGIQKFQIHRDDRSTD-------------------RLPSAHTCFNQ 4344
S+ PL GFA L+ I+ ++ D + D RLP++ TCFN
Sbjct: 980 SRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNL 1039
Query: 4345 LDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
L LP Y LR L AI + GF L+
Sbjct: 1040 LKLPNYSKKSVLREKLRYAI-SMNTGFELS 1068
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 188 bits (477), Expect = 1e-46
Identities = 134/410 (32%), Positives = 215/410 (52%), Gaps = 28/410 (6%)
Query: 3983 AVLVDYIRVLDFDVKRKYFRQEL-----ERLDEGLRKEDMAVHVRRDHVFEDSYRELHRK 4037
AVL + V+ F+ + K F++ + E +G + + V +RR++++ED+Y +L +
Sbjct: 684 AVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPE 743
Query: 4038 SPEEMKNRLYIVFEG-----EEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYT 4092
+ ++K R+ + E G D GG+ RE+ + + FNP F+T+ + + Y
Sbjct: 744 NEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTT-NEGLLYP 802
Query: 4093 INPSSHC--NPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS--VRYTDMES 4148
NP++ + ++ F+GR++ KA+Y+N L+E F F +LG S V + S
Sbjct: 803 -NPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLAS 861
Query: 4149 EDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEY 4206
D Y+ L++L E+DV LG L F+ + G +V +LK G +I VT N+ Y
Sbjct: 862 LDPEVYKNLLFLKSYEDDVEELG--LNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAY 919
Query: 4207 VHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT-IDIDDLKSN 4265
+HLV R+ IR+ AF +G ++ + +F +QE+++LISG I ++DLKS
Sbjct: 920 IHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSF 979
Query: 4266 TEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQ 4324
T Y Y ++ I+ FWR + F ++ K L+FVT S+ PL GF L F
Sbjct: 980 TNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKEL-----YPAFC 1034
Query: 4325 IHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
IH +RLP+A TC N L LP + LR LL AI EC+ GF L+
Sbjct: 1035 IHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAI-ECAAGFELS 1083
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 169,304,996
Number of Sequences: 37866
Number of extensions: 8357058
Number of successful extensions: 113118
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 813
Number of HSP's successfully gapped in prelim test: 1080
Number of HSP's that attempted gapping in prelim test: 46954
Number of HSP's gapped (non-prelim): 35684
length of query: 4374
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4251
effective length of database: 13,590,000
effective search space: 57771090000
effective search space used: 57771090000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.