Search of human proteins with 61675704

Search of human proteins with 61675704

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61675704 hypothetical protein LOC347487 [Homo sapiens]
         (361 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61675704 hypothetical protein LOC347487 [Homo sapiens]             720   0.0  
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    43   5e-04
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor...    42   9e-04
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         40   0.003
gi|236459851 ubinuclein 2 [Homo sapiens]                               39   0.006
gi|114842410 zinc finger CCCH-type containing 11A [Homo sapiens]       39   0.007
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        39   0.009
gi|8923040 CDKN2A interacting protein [Homo sapiens]                   38   0.016
gi|33356174 pinin, desmosome associated protein [Homo sapiens]         38   0.016
gi|50083281 KIAA1853 protein [Homo sapiens]                            37   0.021
gi|55741677 SET domain containing 1A [Homo sapiens]                    37   0.027
gi|7019499 peroxisome proliferator-activated receptor gamma, coa...    37   0.036
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         36   0.061
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...    36   0.061
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...    36   0.061
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...    36   0.061
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...    36   0.061
gi|116875765 tight junction protein 1 isoform b [Homo sapiens]         35   0.080
gi|116875767 tight junction protein 1 isoform a [Homo sapiens]         35   0.080
gi|4759310 bestrophin 1 isoform 1 [Homo sapiens]                       35   0.080
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    35   0.080
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    35   0.080
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    35   0.080
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    35   0.080
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    35   0.10 
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    35   0.10 
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...    35   0.10 
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    35   0.10 
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    35   0.10 
gi|150170670 piccolo isoform 2 [Homo sapiens]                          35   0.10 

>gi|61675704 hypothetical protein LOC347487 [Homo sapiens]
          Length = 361

 Score =  720 bits (1859), Expect = 0.0
 Identities = 361/361 (100%), Positives = 361/361 (100%)

Query: 1   MNLVICVLLLSIWKNNCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFV 60
           MNLVICVLLLSIWKNNCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFV
Sbjct: 1   MNLVICVLLLSIWKNNCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFV 60

Query: 61  FICFCYLHYNCLSDDASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSS 120
           FICFCYLHYNCLSDDASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSS
Sbjct: 61  FICFCYLHYNCLSDDASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSS 120

Query: 121 DSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLE 180
           DSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLE
Sbjct: 121 DSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLE 180

Query: 181 KAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPP 240
           KAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPP
Sbjct: 181 KAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPP 240

Query: 241 KHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRPLVNDISEAKEKNTQNLHVS 300
           KHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRPLVNDISEAKEKNTQNLHVS
Sbjct: 241 KHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRPLVNDISEAKEKNTQNLHVS 300

Query: 301 SKVKSSSRSFRKLDSRNNAYGDHVNDSDTMKYYSEVDSDKVIIITCDRGYNQVTSEVTLN 360
           SKVKSSSRSFRKLDSRNNAYGDHVNDSDTMKYYSEVDSDKVIIITCDRGYNQVTSEVTLN
Sbjct: 301 SKVKSSSRSFRKLDSRNNAYGDHVNDSDTMKYYSEVDSDKVIIITCDRGYNQVTSEVTLN 360

Query: 361 D 361
           D
Sbjct: 361 D 361


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 43/163 (26%), Positives = 72/163 (44%), Gaps = 15/163 (9%)

Query: 73  SDDASKAGMVKKKGIAAKS--SKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASA 130
           S D+S     K+KG A +   +K    E +  SQ S       S++ K S  + P R S+
Sbjct: 803 SSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSS-----SSSHKESSKTKPSRPSS 857

Query: 131 QSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPK-RSSKSSCSKKLSKSSHLEKA-HKKGSL 188
           QSS ++++ P     P + +S+ K  +P+  + R    +C +   KS+   K+ HK  S+
Sbjct: 858 QSSKKEMLPP-----PPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSI 912

Query: 189 EKLCKLDYACKLASSDKPVRPPQLFKPL-YSSHPQNEISPSKP 230
            K  +++     +SS+          P    S P     P KP
Sbjct: 913 PKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKP 955


>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 3 [Homo sapiens]
          Length = 568

 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 58/230 (25%), Positives = 93/230 (40%), Gaps = 28/230 (12%)

Query: 114 STADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKL 173
           S++  SS SSS   +S+ SS+      SS    S  +S+   T  S P +  K    K  
Sbjct: 149 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPS 208

Query: 174 SKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPF-G 232
             S   + A K+ S +            SS +  + P+  KPL     + +I P   F  
Sbjct: 209 KDSREHKSAFKEPSRD---------HNKSSKESSKKPKENKPL----KEEKIVPKMAFKE 255

Query: 233 PQELAKPPKHFNPKRSVSLG--------RAALLSNSELAETCQPYKKKHLVAKTYR---P 281
           P+ ++K PK  +   +++ G        R  +  + EL+   +       + K++    P
Sbjct: 256 PKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPP 315

Query: 282 LVNDISEAKEKNTQNLHVS-SKVKSSSRSFRKLDSRNNAYGDHV--NDSD 328
           L+   S  K++     HV   KVK  S +  K  S    + D V  NDSD
Sbjct: 316 LILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSD 365


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 47/189 (24%), Positives = 74/189 (39%), Gaps = 25/189 (13%)

Query: 75   DASKAGMVKKKGIAAKSSKTSFSEAKTASQ-----------------CSPETQPMLSTAD 117
            + S++      G ++ SS +S S ++T  +                 CS  +    S A 
Sbjct: 2555 EESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPAS 2614

Query: 118  KSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSS 177
             SS SSS   +S+ SS+      SS    S  +S+   +  S    SS SS S   S SS
Sbjct: 2615 SSSSSSSSSSSSSSSSSSS---SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2671

Query: 178  HLEKAHKKGSLEKLCKLDYACKLASSDKPVR-PPQLFKPLYSSHPQNEISPSKPFGPQEL 236
              ++     S ++      A   A +  P +   Q  K   S+H   + +P+    PQ  
Sbjct: 2672 TTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPA----PQPQ 2727

Query: 237  AKPPKHFNP 245
            A PP+   P
Sbjct: 2728 APPPQPTQP 2736


>gi|236459851 ubinuclein 2 [Homo sapiens]
          Length = 1347

 Score = 39.3 bits (90), Expect = 0.006
 Identities = 65/254 (25%), Positives = 102/254 (40%), Gaps = 38/254 (14%)

Query: 87   IAAKSSKTSFSEAKTASQCSPETQ-------------PMLSTADKSSD------SSSPER 127
            IAA S     SEA+ AS  +  T+             P+ +T  KS        S++P+ 
Sbjct: 905  IAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQL 964

Query: 128  ASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGS 187
            + + S  +   +P   + P    S G  ++ S+P  S   +     + S++L KA     
Sbjct: 965  SCSSSLIKTSDKPLMYRLPLSTPSPGNGSQGSHPLVS--RTVPSTTTSSNYLAKAMVSQI 1022

Query: 188  LEKLCKLDYAC----KLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHF 243
              +  K  ++     KLA+S KP   P   KPL S  P     PS    P    K     
Sbjct: 1023 STQGFKSPFSMAASPKLAASPKPATSP---KPLPSPKPSASPKPSLSAKPSVSTKLISKS 1079

Query: 244  N--PKRSVSLGRA---ALLSNSELAETCQPYKKKHLVAKTYR--PLVNDISEAKEKN--- 293
            N  PK +VS   +   AL++    + T  P  K+       R  P +N +  ++      
Sbjct: 1080 NPTPKPTVSPSSSSPNALVAQGSHSSTNSPVHKQPSGMNISRQSPTLNLLPSSRTSGLPP 1139

Query: 294  TQNLHVSSKVKSSS 307
            T+NL   SK+ +SS
Sbjct: 1140 TKNLQAPSKLTNSS 1153


>gi|114842410 zinc finger CCCH-type containing 11A [Homo sapiens]
          Length = 810

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 48/246 (19%), Positives = 95/246 (38%), Gaps = 18/246 (7%)

Query: 73  SDDASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQS 132
           SD   K  + ++ G   ++ +T+  +    +Q S   +  L  +    +  + ++ +   
Sbjct: 295 SDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVG 354

Query: 133 -----STEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSS---KSSCSKKLSKSSHL--EKA 182
                + E+++   + QK     +  K   PS    S+   +SS + ++   S +  EK 
Sbjct: 355 EIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKK 414

Query: 183 HKKGSLEKL-CKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPK 241
           H++   E+   K D  C     D  ++   +  P+ +S  Q+E    K    QE+     
Sbjct: 415 HRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEV----- 469

Query: 242 HFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRPLVNDISEAKEKNTQNLHVSS 301
           H      + L +A  +  S  + T  P   +H      R L+        K  +NL   +
Sbjct: 470 HIKTLEEIKLEKALRVQQSSESSTSSP--SQHEATPGARRLLRITKRTGMKEEKNLQEGN 527

Query: 302 KVKSSS 307
           +V S S
Sbjct: 528 EVDSQS 533


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 45/160 (28%), Positives = 61/160 (38%), Gaps = 32/160 (20%)

Query: 98   EAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKL-IRPSSLQK--PS---IPNS 151
            E +++S  S  +    S++  SS SSS   +S+ S    L ++P    K  PS    P  
Sbjct: 2529 ERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKE 2588

Query: 152  AGKLTRPSYP------KRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDK 205
            A +  RP  P      +RSS SS S   S SS    +    S         +   +SS  
Sbjct: 2589 AVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648

Query: 206  PVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNP 245
            P                   SP+KP GPQ L KP     P
Sbjct: 2649 P-------------------SPAKP-GPQALPKPASPKKP 2668



 Score = 35.4 bits (80), Expect = 0.080
 Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 2/92 (2%)

Query: 83   KKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSS 142
            ++   ++ SS +S S + ++S  S  +    S++  SS SSS   + A+   + L +P+S
Sbjct: 2605 RRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPAS 2664

Query: 143  LQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLS 174
             +KP  P    +   P  P  S + S S   S
Sbjct: 2665 PKKP--PPGERRSRSPRKPIDSLRDSRSLSYS 2694



 Score = 32.0 bits (71), Expect = 0.88
 Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 10/79 (12%)

Query: 98   EAKTASQCSPETQPMLSTADKSSDSSS---------PERASAQSSTEKLIRPSSLQKPSI 148
            E  ++++ SPE  P   TA + S SS          P R S++SS E L R + L + S 
Sbjct: 1650 EGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPE-LTRKARLSRRSR 1708

Query: 149  PNSAGKLTRPSYPKRSSKS 167
              S+   TR   P R  +S
Sbjct: 1709 SASSSPETRSRTPPRHRRS 1727



 Score = 29.3 bits (64), Expect = 5.7
 Identities = 43/185 (23%), Positives = 70/185 (37%), Gaps = 24/185 (12%)

Query: 90  KSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSP-ERASAQSSTEKLIRPSS---LQK 145
           + +K+  S+ ++ S  SPE +    ++ +S   SSP  +A ++ S  + +  SS    QK
Sbjct: 730 RKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQK 789

Query: 146 PSIP-------NSAGKLTRPSYPKRS-SKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYA 197
              P       +S  K    + P+RS S SS   K    +   ++H   S     K    
Sbjct: 790 SQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTP 849

Query: 198 CKLASSDKPVRPPQLFKP----LYSSHPQNEISPSKP--------FGPQELAKPPKHFNP 245
            +  S   P    Q   P     + S P  E+    P          P+  +  P   +P
Sbjct: 850 PRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSP 909

Query: 246 KRSVS 250
            RS S
Sbjct: 910 SRSSS 914



 Score = 29.3 bits (64), Expect = 5.7
 Identities = 52/231 (22%), Positives = 86/231 (37%), Gaps = 34/231 (14%)

Query: 89   AKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSS---LQK 145
            ++S  +  S+AKT +     ++   S    S    SP R+ + SS E   +P +    Q 
Sbjct: 1557 SESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQS 1616

Query: 146  PSIPNSAGKLTRP-SYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSD 204
             S  +   K   P + P+RS   S SK    S        +GS             ++  
Sbjct: 1617 GSDSSPEPKAPAPRALPRRSRSGSSSKGRGPS-------PEGS------------SSTES 1657

Query: 205  KPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNPKRSVSLGRAALLSNSELAE 264
             P  PP+       S      S S P    +   PP+  + + S  L R A LS    + 
Sbjct: 1658 SPEHPPK-------SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSA 1710

Query: 265  TCQPYKKKHLVAKTYR-PLVNDISEAKEKNTQNLHVSS---KVKSSSRSFR 311
            +  P  +     +  R P V+    A++  +     S+   + K++SR  R
Sbjct: 1711 SSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGR 1761



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 40/176 (22%), Positives = 60/176 (34%), Gaps = 27/176 (15%)

Query: 107  PETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSK 166
            PE  P       SS SSS   +S+ SS+      SS                     SS 
Sbjct: 2596 PEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSS---------------------SSS 2634

Query: 167  SSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEIS 226
            SS S   S SS    +  K   + L K     K    ++  R P+  KP+ S      +S
Sbjct: 2635 SSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPR--KPIDSLRDSRSLS 2692

Query: 227  PSKPFGPQELAKPPKHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRPL 282
                + P E  +P    +P+   S          +  ++  P  K+     + RP+
Sbjct: 2693 ----YSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPM 2744


>gi|8923040 CDKN2A interacting protein [Homo sapiens]
          Length = 580

 Score = 37.7 bits (86), Expect = 0.016
 Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 5/134 (3%)

Query: 86  GIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQK 145
           G+ +K+S  +   +  A   S     +L+   KSS S++    +++S+++  +  S L  
Sbjct: 318 GLTSKTSSEASVSSSVAKNSSSSGTSLLTP--KSSSSTNTSLLTSKSTSQ--VAASLLAS 373

Query: 146 PSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDK 205
            S   ++G L   S    S     SK  S++S  +   K  S      + ++CKL + D 
Sbjct: 374 KSSSQTSGSLVSKSTSLASVSQLASKSSSQTSTSQLPSKSTSQSSESSVKFSCKLTNEDV 433

Query: 206 PVRPPQLFKPLYSS 219
             + P  F  LY +
Sbjct: 434 KQKQP-FFNRLYKT 446



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 33/117 (28%), Positives = 49/117 (41%), Gaps = 15/117 (12%)

Query: 68  HYNCLSDDASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSD------ 121
           H    +D   ++G  KK  +   S+        +ASQ S E +  L  +  SS+      
Sbjct: 255 HMTQSTDSRQQSGSPKKSALEGSSA--------SASQSSSEIEVPLLGSSGSSEVELPLL 306

Query: 122 SSSPERASAQSS-TEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSS 177
           SS P   +A S  T K    +S+      NS+   T    PK SS ++ S   SKS+
Sbjct: 307 SSKPSSETASSGLTSKTSSEASVSSSVAKNSSSSGTSLLTPKSSSSTNTSLLTSKST 363


>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
          Length = 717

 Score = 37.7 bits (86), Expect = 0.016
 Identities = 33/129 (25%), Positives = 57/129 (44%), Gaps = 15/129 (11%)

Query: 92  SKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNS 151
           +KTS S ++++S  S  +    S++  SS S S    S+ SS+      SS    S  +S
Sbjct: 568 NKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSS 627

Query: 152 AGKLTRPSYPK-----RSSKSSCSKKLSKSSHLEKAHK----------KGSLEKLCKLDY 196
           + +    S  +     R  + S  +K   +S LE++HK          KGS +K  + D 
Sbjct: 628 SSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDR 687

Query: 197 ACKLASSDK 205
              ++ S +
Sbjct: 688 KRSISESSR 696


>gi|50083281 KIAA1853 protein [Homo sapiens]
          Length = 611

 Score = 37.4 bits (85), Expect = 0.021
 Identities = 52/252 (20%), Positives = 107/252 (42%), Gaps = 13/252 (5%)

Query: 82  VKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPS 141
           VKK  +   ++++S  +  + S     T+    ++   +  +SP    ++S++ +  + S
Sbjct: 371 VKKSSLVPSTARSSPMKGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSE--KRS 428

Query: 142 SLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLE-KAHKKGSLEKLCKLDYACKL 200
             + PS  + +GK + PS   RS +S    + S S   + K  +K S ++  + + A + 
Sbjct: 429 YSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQR--ERERARRR 486

Query: 201 ASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNPKRSVSL-GRAALLSN 259
             S  P+R  +   P   SH +     S    P    +P    +P  S SL   ++  S+
Sbjct: 487 RRSYSPMRKRRRDSP---SHLEARRITSARKRPIPYYRP----SPSSSGSLSSTSSWYSS 539

Query: 260 SELAETCQPYKKKHLVAKTYRPLVNDISEAKEKNTQNLHVSSKVKSSSRSFRKLDSRNNA 319
           S      + Y +    +++ R      S +    + +    S+ +S SRS  +  S++ +
Sbjct: 540 SSSRSASRSYSRSRSRSRSRRRSRTRTSSSSSSRSPSPGSRSRSRSRSRSRSRSRSQSRS 599

Query: 320 YGDHVNDSDTMK 331
           Y    + S T +
Sbjct: 600 YSSADSYSSTRR 611



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 48/222 (21%), Positives = 85/222 (38%), Gaps = 31/222 (13%)

Query: 103 SQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPK 162
           S C    +   S+   S+  SSP +  ++SS+    R SS    S PN       P Y +
Sbjct: 363 SPCLECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRSSSHSSRS-PNPRAS---PRYTQ 418

Query: 163 RSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFK-PLYSSHP 221
             S SS  +  S+S                   Y+ K      P R  +  + P YS + 
Sbjct: 419 SRSTSSEKRSYSRSP-----------------SYSSKSGKRSPPSRSSRSRRSPSYSRY- 460

Query: 222 QNEISPSKPFGPQELAKPPKHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRP 281
               SPS+   P+   K  +    +R+    R+         ++    + + + +   RP
Sbjct: 461 ----SPSRERDPKYSEKDSQQRERERARRRRRSYSPMRKRRRDSPSHLEARRITSARKRP 516

Query: 282 L----VNDISEAKEKNTQNLHVSSKVKSSSRSFRKLDSRNNA 319
           +     +  S     +T + + SS  +S+SRS+ +  SR+ +
Sbjct: 517 IPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRSRS 558



 Score = 28.9 bits (63), Expect = 7.5
 Identities = 27/101 (26%), Positives = 38/101 (37%), Gaps = 8/101 (7%)

Query: 83  KKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSS 142
           KKK       + SFS+ +  S  SP+++       K    S P ++          R  S
Sbjct: 135 KKKSSKKHKRRRSFSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSHRHRHHRCPSRSQS 194

Query: 143 LQKPSIPNSAGKLTRPSYPKRSSKS------SCSKKLSKSS 177
            +  S P+S     R   P+   KS       CSK L K S
Sbjct: 195 SE--SRPSSCESRHRGRSPEEGQKSRRRHSRRCSKTLCKDS 233


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 40/188 (21%), Positives = 65/188 (34%), Gaps = 25/188 (13%)

Query: 83   KKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSS 142
            +++G      + SF+      + S E+       D   D    +R  A  +T+K    S 
Sbjct: 946  EERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSD 1005

Query: 143  LQKPSIPNSA-----------GKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKL 191
             +     +S+              T  S    SS SS S   S SS    +  + S E  
Sbjct: 1006 GEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDE 1065

Query: 192  CKLDYACKLASSDKPVR--------------PPQLFKPLYSSHPQNEISPSKPFGPQELA 237
             + +    L S+  P R              P ++     +  P+ E SP++P GP E +
Sbjct: 1066 EEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEES 1125

Query: 238  KPPKHFNP 245
             P     P
Sbjct: 1126 PPSAPLRP 1133


>gi|7019499 peroxisome proliferator-activated receptor gamma,
           coactivator 1 alpha [Homo sapiens]
          Length = 798

 Score = 36.6 bits (83), Expect = 0.036
 Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 14/143 (9%)

Query: 101 TASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKL-IRPSSLQKPSIPNSAGKLTRPS 159
           T +   P T+P  +        +S +++  QS ++ L  +P++L  P  P S        
Sbjct: 215 TTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSP 274

Query: 160 YPKRSSKSSCSKKLSKSSHL-------EKAHKKGSLEKLCKLDYACKLASSDKPVRPPQL 212
           +  ++ + + S +LS ++ L        KA++        KL  +CK       V PP  
Sbjct: 275 FENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKT------VVPPPS 328

Query: 213 FKPLYSSHPQNEISPSKPFGPQE 235
            KP YS     + + S   GP++
Sbjct: 329 KKPRYSESSGTQGNNSTKKGPEQ 351



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 7/86 (8%)

Query: 101 TASQCSPETQPMLSTADKSSDSSSPERASAQ-SSTEKLIRPSSLQKPSIPNSAGKLTRPS 159
           TA    P T P  +  D      +P RAS +  S+ K + P   +KP    S+G     S
Sbjct: 291 TAGLTPPTTPPHKANQD------NPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNS 344

Query: 160 YPKRSSKSSCSKKLSKSSHLEKAHKK 185
             K   +S    +LSKSS L   H++
Sbjct: 345 TKKGPEQSELYAQLSKSSVLTGGHEE 370


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 43/152 (28%), Positives = 57/152 (37%), Gaps = 11/152 (7%)

Query: 87   IAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPS-SLQK 145
            +  K    S S  K +S  S  T   +S  D  S  S        S T +L +P   L+ 
Sbjct: 2231 VKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKY 2290

Query: 146  PSIPNSA--GKLTRPSYPKRSSKSSC----SKKLSKSSHLEKAHKKGSLEKLCKLDYACK 199
            PS P SA   K  R   P    +S      S  LS SS             + KL    K
Sbjct: 2291 PSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKL----K 2346

Query: 200  LASSDKPVRPPQLFKPLYSSHPQNEISPSKPF 231
            +A+ D+ V+     K  + S PQ+   P K F
Sbjct: 2347 MAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIF 2378


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 33/144 (22%), Positives = 57/144 (39%), Gaps = 20/144 (13%)

Query: 16  NCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFVFICFCYLHYNCLSDD 75
           NC+      GS  +G  P    + K  YL         I++++ +FI  C L+  C    
Sbjct: 652 NCLIKGY-GGSVDSGPPPKRKKKKKFCYLC--------ILLLIVLFILLCCLYRLCKKSK 702

Query: 76  ASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTE 135
             K    K++ +   S+K      +   +  P++QP +  +      S P    +QS  +
Sbjct: 703 PIK----KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPS-----QSQPPVTPSQSHPQ 753

Query: 136 KLIRPSSLQKPSIPNSAGKLTRPS 159
             + PS  Q P  P+ +     PS
Sbjct: 754 --VMPSQSQPPVTPSQSQPRVMPS 775


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 33/144 (22%), Positives = 57/144 (39%), Gaps = 20/144 (13%)

Query: 16  NCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFVFICFCYLHYNCLSDD 75
           NC+      GS  +G  P    + K  YL         I++++ +FI  C L+  C    
Sbjct: 652 NCLIKGY-GGSVDSGPPPKRKKKKKFCYLC--------ILLLIVLFILLCCLYRLCKKSK 702

Query: 76  ASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTE 135
             K    K++ +   S+K      +   +  P++QP +  +      S P    +QS  +
Sbjct: 703 PIK----KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPS-----QSQPPVTPSQSHPQ 753

Query: 136 KLIRPSSLQKPSIPNSAGKLTRPS 159
             + PS  Q P  P+ +     PS
Sbjct: 754 --VMPSQSQPPVTPSQSQPRVMPS 775


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 33/144 (22%), Positives = 57/144 (39%), Gaps = 20/144 (13%)

Query: 16  NCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFVFICFCYLHYNCLSDD 75
           NC+      GS  +G  P    + K  YL         I++++ +FI  C L+  C    
Sbjct: 652 NCLIKGY-GGSVDSGPPPKRKKKKKFCYLC--------ILLLIVLFILLCCLYRLCKKSK 702

Query: 76  ASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTE 135
             K    K++ +   S+K      +   +  P++QP +  +      S P    +QS  +
Sbjct: 703 PIK----KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPS-----QSQPPVTPSQSHPQ 753

Query: 136 KLIRPSSLQKPSIPNSAGKLTRPS 159
             + PS  Q P  P+ +     PS
Sbjct: 754 --VMPSQSQPPVTPSQSQPRVMPS 775


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 33/144 (22%), Positives = 57/144 (39%), Gaps = 20/144 (13%)

Query: 16  NCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFVFICFCYLHYNCLSDD 75
           NC+      GS  +G  P    + K  YL         I++++ +FI  C L+  C    
Sbjct: 652 NCLIKGY-GGSVDSGPPPKRKKKKKFCYLC--------ILLLIVLFILLCCLYRLCKKSK 702

Query: 76  ASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTE 135
             K    K++ +   S+K      +   +  P++QP +  +      S P    +QS  +
Sbjct: 703 PIK----KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPS-----QSQPPVTPSQSHPQ 753

Query: 136 KLIRPSSLQKPSIPNSAGKLTRPS 159
             + PS  Q P  P+ +     PS
Sbjct: 754 --VMPSQSQPPVTPSQSQPRVMPS 775


>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
          Length = 1668

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 39/163 (23%), Positives = 59/163 (36%), Gaps = 9/163 (5%)

Query: 91   SSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSI-P 149
            S +  F   +  +  S +++P    A ++S     E+ +    T   +RP +   PS  P
Sbjct: 1044 SERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGP 1103

Query: 150  NSA-GKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVR 208
              A  K     Y +   +       S++ H E  H   ++  L         +S  KP  
Sbjct: 1104 KPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIP-------SSQHKPEA 1156

Query: 209  PPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNPKRSVSL 251
             P   KPL     Q E        PQ +    K F  KRS SL
Sbjct: 1157 LPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASL 1199



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 34/118 (28%), Positives = 43/118 (36%), Gaps = 15/118 (12%)

Query: 119  SSDSSSPERASAQSST-EKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSS 177
            SS    PE      S  EK   P     P  P    +  +PS P  S+        S   
Sbjct: 1319 SSKGKPPEADGVDRSFGEKRYEPIQATPPP-PPLPSQYAQPSQPVTSA--------SLHI 1369

Query: 178  HLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQE 235
            H + AH +G+      LD+   L S  KP  PP   KP     P  E +    F PQ+
Sbjct: 1370 HSKGAHGEGNS---VSLDFQNSLVS--KPDPPPSQNKPATFRPPNREDTAQAAFYPQK 1422


>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
          Length = 1748

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 39/163 (23%), Positives = 59/163 (36%), Gaps = 9/163 (5%)

Query: 91   SSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSI-P 149
            S +  F   +  +  S +++P    A ++S     E+ +    T   +RP +   PS  P
Sbjct: 1124 SERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGP 1183

Query: 150  NSA-GKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVR 208
              A  K     Y +   +       S++ H E  H   ++  L         +S  KP  
Sbjct: 1184 KPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIP-------SSQHKPEA 1236

Query: 209  PPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNPKRSVSL 251
             P   KPL     Q E        PQ +    K F  KRS SL
Sbjct: 1237 LPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASL 1279



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 34/118 (28%), Positives = 43/118 (36%), Gaps = 15/118 (12%)

Query: 119  SSDSSSPERASAQSST-EKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSS 177
            SS    PE      S  EK   P     P  P    +  +PS P  S+        S   
Sbjct: 1399 SSKGKPPEADGVDRSFGEKRYEPIQATPPP-PPLPSQYAQPSQPVTSA--------SLHI 1449

Query: 178  HLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQE 235
            H + AH +G+      LD+   L S  KP  PP   KP     P  E +    F PQ+
Sbjct: 1450 HSKGAHGEGNS---VSLDFQNSLVS--KPDPPPSQNKPATFRPPNREDTAQAAFYPQK 1502


>gi|4759310 bestrophin 1 isoform 1 [Homo sapiens]
          Length = 585

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 28/191 (14%)

Query: 149 PNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVR 208
           P  A   T+  +PKR  +S   + L K+    K + +G  +     + A KL + D    
Sbjct: 403 PPRANSRTKLLWPKR--ESLLHEGLPKNHKAAKQNVRGQED-----NKAWKLKAVDAFKS 455

Query: 209 PPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFN---------PKRSVSLGRA---AL 256
            P   +P Y S PQ  +SP+  F P E + P K  +           ++VS G      L
Sbjct: 456 APLYQRPGYYSAPQTPLSPTPMFFPLEPSAPSKLHSVTGIDTKDKSLKTVSSGAKKSFEL 515

Query: 257 LSNSELA-----ETCQPYKKKHLVAKTYRPLV--NDISEAKEKNTQNLHVSSKVKSSSRS 309
           LS S+ A     E  Q  +K      T  P +  N + E  E++  N+H +  +K     
Sbjct: 516 LSESDGALMEHPEVSQVRRKTVEFNLTDMPEIPENHLKEPLEQSPTNIHTT--LKDHMDP 573

Query: 310 FRKLDSRNNAY 320
           +  L++R+ A+
Sbjct: 574 YWALENRDEAH 584


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 42/155 (27%), Positives = 63/155 (40%), Gaps = 7/155 (4%)

Query: 106 SPETQPMLST-ADKSSDSSSPERASAQSSTEKLIRPSS---LQKPSIPNSAGKLTRPSYP 161
           +P  +P   T   + S SS+ E ++ + S     RPS+   LQ+P+  + +   T  S P
Sbjct: 184 APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243

Query: 162 KRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHP 221
            RS  S+     + + H  +   KG L+ L +            P   P    PL +  P
Sbjct: 244 ARSGPSARGTPRAPA-HPSQPKPKG-LQAL-RPPQVTPPRKDAAPALGPLSSSPLATPSP 300

Query: 222 QNEISPSKPFGPQELAKPPKHFNPKRSVSLGRAAL 256
               SPS P   Q L  PP     + + SLG   L
Sbjct: 301 SAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 335



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 44/192 (22%), Positives = 73/192 (38%), Gaps = 15/192 (7%)

Query: 77  SKAGMVKKKGIAAKSSKT----SFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQS 132
           ++ G + +KG+   + +T      +EA   S  S   +   S     + S +  R S  +
Sbjct: 115 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAA 174

Query: 133 STEK-LIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKL 191
            TE  L RP+   +P  P           P++S  S+     ++ S    A ++ S    
Sbjct: 175 GTEVGLPRPAPSARPRPPTEG--------PRKSVSSASEHSTTEPS--PAARRRPSAGGG 224

Query: 192 CKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNPKRSVSL 251
            +   +  L+SS  P+  P    P     P+    PS+P      A  P    P R  + 
Sbjct: 225 LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 284

Query: 252 GRAALLSNSELA 263
                LS+S LA
Sbjct: 285 PALGPLSSSPLA 296


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 28/189 (14%)

Query: 84  KKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSL 143
           K+G   K+ + +    K     S E        D    S+ P +    +  +  ++PS  
Sbjct: 108 KEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 167

Query: 144 QKPSIPNSAGKLTRP------------------SYPKRSSKSSCSKK--LSKSSHLEKAH 183
           ++  IP S  +  +P                  + PK S K S  K+  +SKS       
Sbjct: 168 KESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQP 227

Query: 184 KKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHP---QNEISPSK---PFGPQELA 237
           K+G L K   L+ A +    D P  P +  +P     P   +  I P +   P  P+E  
Sbjct: 228 KEGDLPK--SLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETI 285

Query: 238 KPPKHFNPK 246
           +P K   PK
Sbjct: 286 QPKKGDIPK 294



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 19/191 (9%)

Query: 119 SSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSH 178
           S+++S P++  +  S+E+ I+P     P  P    +  +   PK S K+       K S+
Sbjct: 26  SANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAI----QPKESN 81

Query: 179 LEKAHKKGSLEKLCKLDYACKLASSDK----PVRPPQLFKPLYSSHPQNE---ISPSKPF 231
           + K+  K    KL  +  A    S  K    P  P +  +      P++    I P +  
Sbjct: 82  IPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGD 141

Query: 232 GPQELAKP--PKHFN-PKRSV--SLGRAALLSNSELAETCQPYKK--KHLVAKTYRPLVN 284
            P+  AKP  PK  N  K SV  S  + + +  S   ET QP +       AK  +P + 
Sbjct: 142 IPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSP-EETIQPKEGDIPKSSAKPIQPKLG 200

Query: 285 DISEAKEKNTQ 295
           +I +A  K +Q
Sbjct: 201 NIPKASVKPSQ 211


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 28/189 (14%)

Query: 84  KKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSL 143
           K+G   K+ + +    K     S E        D    S+ P +    +  +  ++PS  
Sbjct: 175 KEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 234

Query: 144 QKPSIPNSAGKLTRP------------------SYPKRSSKSSCSKK--LSKSSHLEKAH 183
           ++  IP S  +  +P                  + PK S K S  K+  +SKS       
Sbjct: 235 KESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQP 294

Query: 184 KKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHP---QNEISPSK---PFGPQELA 237
           K+G L K   L+ A +    D P  P +  +P     P   +  I P +   P  P+E  
Sbjct: 295 KEGDLPK--SLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETI 352

Query: 238 KPPKHFNPK 246
           +P K   PK
Sbjct: 353 QPKKGDIPK 361



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 19/191 (9%)

Query: 119 SSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSH 178
           S+++S P++  +  S+E+ I+P     P  P    +  +   PK S K+       K S+
Sbjct: 93  SANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAI----QPKESN 148

Query: 179 LEKAHKKGSLEKLCKLDYACKLASSDK----PVRPPQLFKPLYSSHPQNE---ISPSKPF 231
           + K+  K    KL  +  A    S  K    P  P +  +      P++    I P +  
Sbjct: 149 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGD 208

Query: 232 GPQELAKP--PKHFN-PKRSV--SLGRAALLSNSELAETCQPYKK--KHLVAKTYRPLVN 284
            P+  AKP  PK  N  K SV  S  + + +  S   ET QP +       AK  +P + 
Sbjct: 209 IPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSP-EETIQPKEGDIPKSSAKPIQPKLG 267

Query: 285 DISEAKEKNTQ 295
           +I +A  K +Q
Sbjct: 268 NIPKASVKPSQ 278


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 28/189 (14%)

Query: 84  KKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSL 143
           K+G   K+ + +    K     S E        D    S+ P +    +  +  ++PS  
Sbjct: 108 KEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 167

Query: 144 QKPSIPNSAGKLTRP------------------SYPKRSSKSSCSKK--LSKSSHLEKAH 183
           ++  IP S  +  +P                  + PK S K S  K+  +SKS       
Sbjct: 168 KESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQP 227

Query: 184 KKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHP---QNEISPSK---PFGPQELA 237
           K+G L K   L+ A +    D P  P +  +P     P   +  I P +   P  P+E  
Sbjct: 228 KEGDLPK--SLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETI 285

Query: 238 KPPKHFNPK 246
           +P K   PK
Sbjct: 286 QPKKGDIPK 294



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 19/191 (9%)

Query: 119 SSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSH 178
           S+++S P++  +  S+E+ I+P     P  P    +  +   PK S K+       K S+
Sbjct: 26  SANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAI----QPKESN 81

Query: 179 LEKAHKKGSLEKLCKLDYACKLASSDK----PVRPPQLFKPLYSSHPQNE---ISPSKPF 231
           + K+  K    KL  +  A    S  K    P  P +  +      P++    I P +  
Sbjct: 82  IPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGD 141

Query: 232 GPQELAKP--PKHFN-PKRSV--SLGRAALLSNSELAETCQPYKK--KHLVAKTYRPLVN 284
            P+  AKP  PK  N  K SV  S  + + +  S   ET QP +       AK  +P + 
Sbjct: 142 IPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSP-EETIQPKEGDIPKSSAKPIQPKLG 200

Query: 285 DISEAKEKNTQ 295
           +I +A  K +Q
Sbjct: 201 NIPKASVKPSQ 211


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 41/147 (27%), Positives = 60/147 (40%), Gaps = 14/147 (9%)

Query: 107 PETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSK 166
           PE + +LS   K +    PE++   SS  +     SL  PS+         PS   R  +
Sbjct: 510 PEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSV--RQIR 567

Query: 167 SSCSKKLSKSSHLEKAHKKGSLEKLCKLD--YACKLASSD----KPVR---PPQ--LFKP 215
           +    +LS ++  E     GSL    +L+    C+  + D    KPV    PPQ     P
Sbjct: 568 NELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLP 627

Query: 216 LYSSHPQNEISPS-KPFGPQELAKPPK 241
             S  P+  + P+  P    E A PPK
Sbjct: 628 TTSLQPKAMLGPAIPPKATPEPAIPPK 654


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 41/147 (27%), Positives = 60/147 (40%), Gaps = 14/147 (9%)

Query: 107 PETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSK 166
           PE + +LS   K +    PE++   SS  +     SL  PS+         PS   R  +
Sbjct: 510 PEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSV--RQIR 567

Query: 167 SSCSKKLSKSSHLEKAHKKGSLEKLCKLD--YACKLASSD----KPVR---PPQ--LFKP 215
           +    +LS ++  E     GSL    +L+    C+  + D    KPV    PPQ     P
Sbjct: 568 NELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLP 627

Query: 216 LYSSHPQNEISPS-KPFGPQELAKPPK 241
             S  P+  + P+  P    E A PPK
Sbjct: 628 TTSLQPKAMLGPAIPPKATPEPAIPPK 654


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 41/147 (27%), Positives = 60/147 (40%), Gaps = 14/147 (9%)

Query: 107 PETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSK 166
           PE + +LS   K +    PE++   SS  +     SL  PS+         PS   R  +
Sbjct: 510 PEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSV--RQIR 567

Query: 167 SSCSKKLSKSSHLEKAHKKGSLEKLCKLD--YACKLASSD----KPVR---PPQ--LFKP 215
           +    +LS ++  E     GSL    +L+    C+  + D    KPV    PPQ     P
Sbjct: 568 NELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLP 627

Query: 216 LYSSHPQNEISPS-KPFGPQELAKPPK 241
             S  P+  + P+  P    E A PPK
Sbjct: 628 TTSLQPKAMLGPAIPPKATPEPAIPPK 654


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens]
          Length = 2462

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 39/152 (25%), Positives = 59/152 (38%), Gaps = 31/152 (20%)

Query: 110  QPMLSTADKSSDSSSPERASAQ---------SSTEKLIRPSSLQKPSIPNSAGKLTRPSY 160
            +P   T  +S+ +SSP R +A            T   + P+ ++   +P  A ++ RP  
Sbjct: 1882 EPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPER 1941

Query: 161  PKRSSKSSCSKKLSKSSHLEKAHK--KGS--------------LEKLCKLDYACKLASSD 204
            P+  +  +   K    S LE A    KGS              + +    + A   AS D
Sbjct: 1942 PRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPD 2001

Query: 205  KPVRPPQLFKPLYSSHPQNEISPSKPFGPQEL 236
             P  P        +S P  E + SKPF  QEL
Sbjct: 2002 PPAPPAS------ASDPHREKTQSKPFSIQEL 2027


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens]
          Length = 2524

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 39/152 (25%), Positives = 59/152 (38%), Gaps = 31/152 (20%)

Query: 110  QPMLSTADKSSDSSSPERASAQ---------SSTEKLIRPSSLQKPSIPNSAGKLTRPSY 160
            +P   T  +S+ +SSP R +A            T   + P+ ++   +P  A ++ RP  
Sbjct: 1898 EPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPER 1957

Query: 161  PKRSSKSSCSKKLSKSSHLEKAHK--KGS--------------LEKLCKLDYACKLASSD 204
            P+  +  +   K    S LE A    KGS              + +    + A   AS D
Sbjct: 1958 PRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPD 2017

Query: 205  KPVRPPQLFKPLYSSHPQNEISPSKPFGPQEL 236
             P  P        +S P  E + SKPF  QEL
Sbjct: 2018 PPAPPAS------ASDPHREKTQSKPFSIQEL 2043


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 33/137 (24%), Positives = 60/137 (43%), Gaps = 9/137 (6%)

Query: 92   SKTSFSEAKTASQCSPETQP-MLSTADKSSDSS-SPERASAQSSTEKLIRPSSLQKPSIP 149
            S+   S +  AS  +P T P  +S+ D+ SDSS S ++  ++   +   RP     P+I 
Sbjct: 1712 SRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIE 1771

Query: 150  NSAGKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCK-LDYACKLASSDKPVR 208
            +S+ +       +   +    K+  K   +E+  +K S +K  K  D        ++P  
Sbjct: 1772 DSSEE------EELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKT 1825

Query: 209  PPQLFKPLYSSHPQNEI 225
            PP    P+  + P  E+
Sbjct: 1826 PPSNLSPIEDASPTEEL 1842



 Score = 28.9 bits (63), Expect = 7.5
 Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 4/111 (3%)

Query: 98   EAKTASQCSPETQPMLST--ADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKL 155
            +A   SQ      P  ST  A  +   S P +   ++   + + P + Q P++  +  + 
Sbjct: 966  QAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEK 1025

Query: 156  TRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKP 206
              P      S ++  +K    + LEK+ K  S   LCK +    + S D P
Sbjct: 1026 KPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTE--LNIGSKDPP 1074


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.125    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,520,951
Number of Sequences: 37866
Number of extensions: 605283
Number of successful extensions: 3527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 218
Number of HSP's that attempted gapping in prelim test: 3212
Number of HSP's gapped (non-prelim): 504
length of query: 361
length of database: 18,247,518
effective HSP length: 104
effective length of query: 257
effective length of database: 14,309,454
effective search space: 3677529678
effective search space used: 3677529678
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.