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Search of human proteins with 61563742
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61563742 hect domain and RLD 6 [Homo sapiens]
(1022 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61563742 hect domain and RLD 6 [Homo sapiens] 2073 0.0
gi|110825982 hect domain and RLD 5 [Homo sapiens] 936 0.0
gi|7657152 hect domain and RLD 3 [Homo sapiens] 659 0.0
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 651 0.0
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 649 0.0
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 226 8e-59
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 226 8e-59
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 226 8e-59
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 179 2e-44
gi|126032348 hect domain and RLD 2 [Homo sapiens] 154 4e-37
gi|222352183 neural precursor cell expressed, developmentally do... 152 1e-36
gi|21361472 neural precursor cell expressed, developmentally dow... 152 1e-36
gi|222352094 neural precursor cell expressed, developmentally do... 152 1e-36
gi|222352092 neural precursor cell expressed, developmentally do... 152 1e-36
gi|222352090 neural precursor cell expressed, developmentally do... 152 1e-36
gi|222352088 neural precursor cell expressed, developmentally do... 152 1e-36
gi|222352086 neural precursor cell expressed, developmentally do... 152 1e-36
gi|222352084 neural precursor cell expressed, developmentally do... 152 1e-36
gi|222352082 neural precursor cell expressed, developmentally do... 152 1e-36
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 150 8e-36
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 145 2e-34
gi|114520609 neural precursor cell expressed, developmentally do... 144 4e-34
gi|114520607 neural precursor cell expressed, developmentally do... 144 4e-34
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 143 7e-34
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 143 7e-34
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 139 2e-32
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 139 2e-32
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 135 3e-31
gi|4557445 regulator of chromosome condensation and BTB domain c... 129 1e-29
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 127 7e-29
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 2073 bits (5370), Expect = 0.0
Identities = 1022/1022 (100%), Positives = 1022/1022 (100%)
Query: 1 MYFCWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGA 60
MYFCWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGA
Sbjct: 1 MYFCWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGA 60
Query: 61 QRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPK 120
QRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPK
Sbjct: 61 QRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPK 120
Query: 121 KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEG 180
KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEG
Sbjct: 121 KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEG 180
Query: 181 IPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVY 240
IPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVY
Sbjct: 181 IPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVY 240
Query: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTL 300
ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTL
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTL 300
Query: 301 AYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFV 360
AYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFV
Sbjct: 301 AYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFV 360
Query: 361 TTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTAS 420
TTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTAS
Sbjct: 361 TTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTAS 420
Query: 421 FLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEALS 480
FLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEALS
Sbjct: 421 FLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEALS 480
Query: 481 VFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKA 540
VFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKA
Sbjct: 481 VFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKA 540
Query: 541 AIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRG 600
AIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRG
Sbjct: 541 AIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRG 600
Query: 601 RQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETIL 660
RQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETIL
Sbjct: 601 RQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETIL 660
Query: 661 QKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEF 720
QKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEF
Sbjct: 661 QKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEF 720
Query: 721 FHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFP 780
FHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFP
Sbjct: 721 FHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFP 780
Query: 781 LALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVDLIP 840
LALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVDLIP
Sbjct: 781 LALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVDLIP 840
Query: 841 NGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAI 900
NGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAI
Sbjct: 841 NGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAI 900
Query: 901 IGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARG 960
IGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARG
Sbjct: 901 IGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARG 960
Query: 961 IQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGFVSPMLT 1020
IQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGFVSPMLT
Sbjct: 961 IQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGFVSPMLT 1020
Query: 1021 QS 1022
QS
Sbjct: 1021 QS 1022
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 936 bits (2418), Expect = 0.0
Identities = 504/1017 (49%), Positives = 671/1017 (65%), Gaps = 39/1017 (3%)
Query: 18 AGSPGAEL--LQAASGERHSLLLLTN-HRVLSCGDNSRGQLGRRGAQ-----------RG 63
A SPGA+L +A+G +LL R L C L R GA
Sbjct: 26 AKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLAVLERGGAGVQVHQLLAGSGGA 85
Query: 64 ELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM 123
P+ I+ + + + V G EH L + G+ F + S L F+ I
Sbjct: 86 RTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHL---RFESI-------- 134
Query: 124 TLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 183
L + KIIQ++CG YHSLALSK ++F+WG+N HGQLG+G++FPS +PQ V L G+PL
Sbjct: 135 -LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPL 193
Query: 184 AQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243
AQ++AG AHS ALS+ G + WG N GQL L + P + L N V +++C
Sbjct: 194 AQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTE---SKDDPSLIEGLDNQKVEFVAC 250
Query: 244 GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302
G +H+A+LTQDG +FTFG + GQLG++ T + P LV + G V+QI CG +HTLAY
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAY 310
Query: 303 VHTTGQVVSFGHGPSDT--SKPTHPEALTENFDISCL--ISAEDFVDVQVKHIFAGTYAN 358
V G+V SFG G + T + + +S + E + + AG +
Sbjct: 311 VSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQS 370
Query: 359 FVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLT 418
+ + +S +T+P ++ + ++WIA + + K EI+ IFSSPACLT
Sbjct: 371 ILLWIKKENSYVNLKRTIPTLN---EGTVKRWIA-DVETKRWQSTKREIQEIFSSPACLT 426
Query: 419 ASFLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEA 478
SFL+KR T E + +DL AR+ FK+LT+K+WI++MITTCL+D+LL+ LP HSP QEA
Sbjct: 427 GSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFHSPPQEA 486
Query: 479 LSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQML 538
L +F LLPECP+MH S NW++LVVPFAK VC+MS QS VL++ WA LQES+ + L+QM
Sbjct: 487 LEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMF 546
Query: 539 KAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYID 598
K A+I QL + ++ +++ NV+ALL M+K+LH+VN+ C+LPE+ F ++EL + LNF+++
Sbjct: 547 KTAVICQLDYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHRLNFFVE 606
Query: 599 RGRQLFRDNHLIPAETPSP-VIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHE 657
R+ + +E VIFS FPFIFN+LSKIKLL D+ +K++ + KAY+
Sbjct: 607 VCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAA 666
Query: 658 TILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVS 717
+++ EF P F L VRR+ L++D L QLSQ E D K L V F EI + GGV
Sbjct: 667 IEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVK 726
Query: 718 SEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANL 777
EFF+C+F EM +PEYGMFMYPE SCMWFP KPK EKKRYF FG+LCGLSLFN NVANL
Sbjct: 727 KEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANL 786
Query: 778 PFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVD 837
PFPLAL+KKLLDQ PSLEDLKELSP LGK+LQ +LDD D+ + I F++HWD+ND +
Sbjct: 787 PFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTN 846
Query: 838 LIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELM 897
LIPNG SI V+QTNKRDYVSKYI+YIFN SVKAVYEEF+RGFY++C+++I++ F+PEEL
Sbjct: 847 LIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELK 906
Query: 898 TAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 957
I+GNTDYDWK FE+N++YE GY SHPTI +FWKAFHKLTL+EKKKFL FLTG DRL
Sbjct: 907 DVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQ 966
Query: 958 ARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
+ + M+I F CPE+++ERD ++TC ++L LPKYSTME +EEALQ AINNNRGF
Sbjct: 967 MKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 659 bits (1700), Expect = 0.0
Identities = 394/1017 (38%), Positives = 578/1017 (56%), Gaps = 36/1017 (3%)
Query: 27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEH 86
+ A G HS+ LL + V +CG N++GQLG + G PE I AL + V+CG+ H
Sbjct: 38 EVACGGNHSVFLLEDGEVYTCGLNTKGQLGHE--REGNKPEQIGALADQHIIHVACGESH 95
Query: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
SLA+ +G++F+WGAGS+GQLG+ ++ P+ I LN I+QVSCG++H LAL+ D
Sbjct: 96 SLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 155
Query: 147 SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWG 206
Q F+WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL G FGWG
Sbjct: 156 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 215
Query: 207 SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSG 266
N+AGQL LS P V L+ VVYISCG+ HTAVLT+ G VFTFG G
Sbjct: 216 MNNAGQLGLSDEK---DRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272
Query: 267 QLGYSPTPEKRGP-QLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG---------P 316
QLG+ ++ P +++E + V+QI CG HTLA+V ++G + +FG G
Sbjct: 273 QLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332
Query: 317 SDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTL 376
+ P+ + A+ F VK IF+G FV + + + A
Sbjct: 333 CNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRT 392
Query: 377 PEISRISQSMAEKWIAV-KRRSTEHEMAK--SEIRMIFSSPACLTASFLKKRGTGETTSI 433
+ + + ++ IAV +++ +EH A + + I SS AC SFL+K+ +
Sbjct: 393 MNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTS 452
Query: 434 ----DVDLEMARDTFKKL--TKKEWISSMITTCLEDDLLRALPCHSPHQEALSVFLLLPE 487
+DL R F+KL ++ I I E L+ L P EA+ ++L+LPE
Sbjct: 453 PKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPE 512
Query: 488 CPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQLL 547
P++ DSK + L +P A A+ + +VL W+ + L+ + K A++ LL
Sbjct: 513 FPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVL-YLL 571
Query: 548 HQTKT----EQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQL 603
KT + + A L ++++L+KVN + +TF I E+SNL++ D
Sbjct: 572 RGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWF 631
Query: 604 FRDNHL--IPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQ 661
+ P+ V +PFIF++ +K K+LQ D+ ++MQ++ A + +L
Sbjct: 632 LHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLT 691
Query: 662 KKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFF 721
+ SP +L VRR+ LV DALR+LS D K L V F E ++GGV+ EFF
Sbjct: 692 LEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFF 751
Query: 722 HCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPL 781
+ +E+ P YGMF Y + + +WF E + L G+ CGL+++N V +L FPL
Sbjct: 752 LLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPL 811
Query: 782 ALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDV----D 837
ALYKKLL+ KP LEDLKELSP G+SLQE+LD +D+ + C+ F+I + V
Sbjct: 812 ALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKK 871
Query: 838 LIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELM 897
LIP G ++ V + N++++V Y++Y+F +SV Y F GF +VC ++L F P EL
Sbjct: 872 LIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELR 931
Query: 898 TAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 957
++GN++Y+W++ E+ + Y+ Y +HPT++LFW+ FH+ L++KKKFL FLTG DR+
Sbjct: 932 AMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIP 991
Query: 958 ARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
G+ ++IV + + E P + TC+N+L LPKYS+ E + L A++N GF
Sbjct: 992 IYGMASLQIVIQSTAS-GEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
Score = 110 bits (276), Expect = 5e-24
Identities = 74/221 (33%), Positives = 114/221 (51%), Gaps = 9/221 (4%)
Query: 96 VFAWGAGSEGQLGIG-EFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGK 154
+ WG S GQ GI + I P+ ++D + +V+CG HS+ L +D +V++ G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
N+ GQLG +E P+++ +L + VA G +HS ALS G F WG+ S GQL
Sbjct: 61 NTKGQLGHERE---GNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117
Query: 215 LSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPT- 273
L V P + L ++ +SCG+ H L DG+ FT+G N GQLG
Sbjct: 118 LMTTEDSVA--VPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF 175
Query: 274 PEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFG 313
P + PQ V ++G+ ++Q+ G H+ A + +G V +G
Sbjct: 176 PSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWG 215
Score = 92.0 bits (227), Expect = 2e-18
Identities = 56/174 (32%), Positives = 86/174 (49%), Gaps = 13/174 (7%)
Query: 2 YFCWGADSR-----------ELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDN 50
+F WG +S + +R G L Q A+G HS L + V G N
Sbjct: 158 FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMN 217
Query: 51 SRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIG 110
+ GQLG + E P ++ L T V +SCG+EH+ + G VF +GAGS GQLG
Sbjct: 218 NAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHD 277
Query: 111 EFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDS-QVFSWGKNSHGQLGLG 163
+ P++++ L ++ Q++CG H+LA S ++++G + GQLG G
Sbjct: 278 SMND-EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 3/111 (2%)
Query: 205 WGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNR 264
WG S GQ +S N+ +P G + + V ++CG H+ L +DG+V+T G N
Sbjct: 4 WGYWSLGQPGIS-TNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNT 62
Query: 265 SGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
GQLG+ K Q+ D + + CG H+LA + GQ+ S+G G
Sbjct: 63 KGQLGHEREGNK-PEQIGALADQHIIHVACGESHSLA-LSDRGQLFSWGAG 111
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 651 bits (1680), Expect = 0.0
Identities = 387/1025 (37%), Positives = 592/1025 (57%), Gaps = 53/1025 (5%)
Query: 31 GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
G RH++ +L + V +CG N GQLG +++ PE + AL+ + VSCG+ H+LA+
Sbjct: 42 GLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKK--PEQVVALDAQNIVAVSCGEAHTLAL 99
Query: 91 CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150
KG+V+AWG S+GQLG+ +E P+ I +L+DI+I+QV+CG+YHSLALSK S+VF
Sbjct: 100 NDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVF 159
Query: 151 SWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
WG+N +GQLGLG + Q SPQ ++SL GIP QVAAGGAHSF L+L G FGWG N
Sbjct: 160 CWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270
GQL L+ N P + +L++ +VYI CG+ HTA LT++G VFTFG GQLG+
Sbjct: 220 GQLGLNDEN---DRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276
Query: 271 SPTPEKRGPQLV-ERIDGLVSQIDCGSYHTLAYVHTTGQVVSFG------HGPSDTSKPT 323
+ T + P+ V E + +V++I CG HT A+V ++G++ SFG G TS
Sbjct: 277 NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 324 HPEALTEN---FDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSST-------RAPG 373
P + N ++ CL + VK IF+G +F +H + R P
Sbjct: 337 SPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSF--SHYSSPQNCGPPDDFRCPN 394
Query: 374 KTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTASFLKKRG-----TG 428
T +I +++++ +KW++ E+A +EI FSS CL SFL TG
Sbjct: 395 PT-KQIWTVNEALIQKWLSYPSGRFPVEIA-NEIDGTFSSSGCLNGSFLAVSNDDHYRTG 452
Query: 429 ETTSIDVDLEMARDTFKKLTKKE--WISSMITTCLEDDLLRALPCHSPHQEALSVFLLLP 486
T VD+ AR F KL + + IS + LE +L+ L P EAL +L LP
Sbjct: 453 -TRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLP 511
Query: 487 ECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQL 546
ECP+M DS N+ + +PF A+ + K L+VL+ W+ L+ ++++ K ++ L
Sbjct: 512 ECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLL 571
Query: 547 ------LHQTKTEQDHCNVKALLGMMKELHKVN-KANCRLPENTFNINELSNLL---NFY 596
+ ++ + + L +++ LH+VN K + + F I+E+ L+ N Y
Sbjct: 572 KLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDY 631
Query: 597 IDRGRQL---FRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYM 653
I+ +Q NH + PV +PF+F++ +K LLQ D+ ++MQM+ +A+
Sbjct: 632 INWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHR 691
Query: 654 LMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPES 713
++ E +P IL VRR +V DA+ L + + D+ K L V F+ E ++
Sbjct: 692 QNVSSLFLPVIE-SVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDA 750
Query: 714 GGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLN 773
GGV EFF + E+ P+YGMF Y E +WF K + + L G++CGL+++N
Sbjct: 751 GGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNCT 810
Query: 774 VANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSI---H 830
+ +L FPLALYKKLL +KPSL+DLKEL P +G+S+Q++LD DDI + C+ F+I +
Sbjct: 811 IVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVEN 870
Query: 831 WDQNDV-DLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILR 889
+ +V +L+ NG V++ N++++V Y+DYIFN SV ++++ F GF++VC ++L
Sbjct: 871 FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLL 930
Query: 890 HFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFF 949
F P EL +IGNT+YDWK+ E+N++Y+ Y HPTI++FW+ FH+L L++KK+FL F
Sbjct: 931 LFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLF 990
Query: 950 LTGRDRLHARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAIN 1009
LTG DR+ G++ +++V + E P S TC N+L LPKY+ E + L AI+
Sbjct: 991 LTGSDRIPILGMKSLKLVIQSTGG-GEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAID 1049
Query: 1010 NNRGF 1014
+N GF
Sbjct: 1050 HNEGF 1054
Score = 107 bits (266), Expect = 7e-23
Identities = 69/221 (31%), Positives = 120/221 (54%), Gaps = 9/221 (4%)
Query: 96 VFAWGAGSEGQLGIGEF-KEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGK 154
+ WG S GQLG+G +EI P+K + ++ V CG H++ + D V++ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
N GQLG K S+ P++V +L+ + V+ G AH+ AL+ G + WG +S GQL
Sbjct: 61 NDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 215 LSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTP 274
L G ++ P ++ +L ++ +V ++CG H+ L++ +VF +G N+ GQLG
Sbjct: 118 LVGSEECIR--VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDC 175
Query: 275 EKR-GPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFG 313
+K+ PQL++ + G+ Q+ G H+ + +G + +G
Sbjct: 176 KKQTSPQLLKSLLGIPFMQVAAGGAHSFV-LTLSGAIFGWG 215
Score = 92.4 bits (228), Expect = 2e-18
Identities = 58/192 (30%), Positives = 96/192 (50%), Gaps = 4/192 (2%)
Query: 24 ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG-RRGAQRGELPEPIQALETLIVDLVSC 82
+++Q A G HSL L V G N GQLG ++ P+ +++L + V+
Sbjct: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
Query: 83 GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
G HS + G +F WG GQLG+ + + + P + +L KI+ + CG H+ A
Sbjct: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND-RYVPNLLKSLRSQKIVYICCGEDHTAA 256
Query: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLCGT 201
L+K+ VF++G +GQLG + +P++V L G + ++A G H+ A + G
Sbjct: 257 LTKEGGVFTFGAGGYGQLG-HNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGR 315
Query: 202 SFGWGSNSAGQL 213
+ +G GQL
Sbjct: 316 IYSFGLGGNGQL 327
Score = 83.2 bits (204), Expect = 1e-15
Identities = 48/173 (27%), Positives = 82/173 (47%), Gaps = 13/173 (7%)
Query: 3 FCWGADS-----------RELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNS 51
FCWG + ++ + G +Q A+G HS +L + + G N
Sbjct: 159 FCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNK 218
Query: 52 RGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGE 111
GQLG +P +++L + + + CG++H+ A+ +G VF +GAG GQLG
Sbjct: 219 FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278
Query: 112 FKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDS-QVFSWGKNSHGQLGLG 163
P+K+ L + +++CG H+ A S +++S+G +GQLG G
Sbjct: 279 TSH-EINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 649 bits (1675), Expect = 0.0
Identities = 383/1019 (37%), Positives = 591/1019 (57%), Gaps = 49/1019 (4%)
Query: 31 GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
G RH++ +L + V +CG N GQLG +++ PE + AL+ + VSCG+ H+LA+
Sbjct: 42 GLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKK--PEQVVALDAQNIVAVSCGEAHTLAL 99
Query: 91 CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150
KG+V+AWG S+GQLG+ +E P+ I +L+DI+I+QV+CG+YHSLALSK S+VF
Sbjct: 100 NDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVF 159
Query: 151 SWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
WG+N +GQLGLG + Q SPQ ++SL GIP QVAAGGAHSF L+L G FGWG N
Sbjct: 160 CWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
Query: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270
GQL L+ N P + +L++ +VYI CG+ HTA LT++G VFTFG GQLG+
Sbjct: 220 GQLGLNDEN---DRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276
Query: 271 SPTPEKRGPQLV-ERIDGLVSQIDCGSYHTLAYVHTTGQVVSFG------HGPSDTSKPT 323
+ T + P+ V E + +V++I CG HT A+V ++G++ SFG G TS
Sbjct: 277 NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 324 HPEALTEN---FDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSST-------RAPG 373
P + N ++ CL + VK IF+G +F +H + R P
Sbjct: 337 SPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSF--SHYSSPQNCGPPDDFRCPN 394
Query: 374 KTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTASFLKKRG-----TG 428
T +I +++++ +KW++ E+A +EI FSS CL SFL TG
Sbjct: 395 PT-KQIWTVNEALIQKWLSYPSGRFPVEIA-NEIDGTFSSSGCLNGSFLAVSNDDHYRTG 452
Query: 429 ETTSIDVDLEMARDTFKKLTKKE--WISSMITTCLEDDLLRALPCHSPHQEALSVFLLLP 486
T VD+ AR F KL + + IS + LE +L+ L P EAL +L LP
Sbjct: 453 -TRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLP 511
Query: 487 ECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQL 546
ECP+M DS N+ + +PF A+ + K L+VL+ W+ L+ ++++ K ++ L
Sbjct: 512 ECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLL 571
Query: 547 ------LHQTKTEQDHCNVKALLGMMKELHKVN-KANCRLPENTFNINELSNLLNFYIDR 599
+ ++ + + L +++ LH+VN K + + F I+E+ L++ D
Sbjct: 572 KLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDY 631
Query: 600 GRQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETI 659
+ + + + A+ PV +PF+F++ +K LLQ D+ ++MQM+ +A+ ++
Sbjct: 632 INWVQQQAYGMLADI--PVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSL 689
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSE 719
E +P IL VRR +V DA+ L + + D+ K L V F+ E ++GGV E
Sbjct: 690 FLPVIE-SVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKE 748
Query: 720 FFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPF 779
FF + E+ P+YGMF Y E +WF K + + L G++CGL+++N + +L F
Sbjct: 749 FFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHF 808
Query: 780 PLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSI---HWDQNDV 836
PLALYKKLL +KPSL+DLKEL P +G+S+Q++LD DDI + C+ F+I ++ +V
Sbjct: 809 PLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEV 868
Query: 837 -DLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEE 895
+L+ NG V++ N++++V Y+DYIFN SV ++++ F GF++VC ++L F P E
Sbjct: 869 KELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNE 928
Query: 896 LMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDR 955
L +IGNT+YDWK+ E+N++Y+ Y HPTI++FW+ FH+L L++KK+FL FLTG DR
Sbjct: 929 LQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDR 988
Query: 956 LHARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
+ G++ +++V + E P S TC N+L LPKY+ E + L AI++N GF
Sbjct: 989 IPILGMKSLKLVIQSTGG-GEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
Score = 107 bits (266), Expect = 7e-23
Identities = 69/221 (31%), Positives = 120/221 (54%), Gaps = 9/221 (4%)
Query: 96 VFAWGAGSEGQLGIGEF-KEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGK 154
+ WG S GQLG+G +EI P+K + ++ V CG H++ + D V++ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
N GQLG K S+ P++V +L+ + V+ G AH+ AL+ G + WG +S GQL
Sbjct: 61 NDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 215 LSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTP 274
L G ++ P ++ +L ++ +V ++CG H+ L++ +VF +G N+ GQLG
Sbjct: 118 LVGSEECIR--VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDC 175
Query: 275 EKR-GPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFG 313
+K+ PQL++ + G+ Q+ G H+ + +G + +G
Sbjct: 176 KKQTSPQLLKSLLGIPFMQVAAGGAHSFV-LTLSGAIFGWG 215
Score = 92.4 bits (228), Expect = 2e-18
Identities = 58/192 (30%), Positives = 96/192 (50%), Gaps = 4/192 (2%)
Query: 24 ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG-RRGAQRGELPEPIQALETLIVDLVSC 82
+++Q A G HSL L V G N GQLG ++ P+ +++L + V+
Sbjct: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
Query: 83 GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
G HS + G +F WG GQLG+ + + + P + +L KI+ + CG H+ A
Sbjct: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND-RYVPNLLKSLRSQKIVYICCGEDHTAA 256
Query: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLCGT 201
L+K+ VF++G +GQLG + +P++V L G + ++A G H+ A + G
Sbjct: 257 LTKEGGVFTFGAGGYGQLG-HNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGR 315
Query: 202 SFGWGSNSAGQL 213
+ +G GQL
Sbjct: 316 IYSFGLGGNGQL 327
Score = 83.2 bits (204), Expect = 1e-15
Identities = 48/173 (27%), Positives = 82/173 (47%), Gaps = 13/173 (7%)
Query: 3 FCWGADS-----------RELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNS 51
FCWG + ++ + G +Q A+G HS +L + + G N
Sbjct: 159 FCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNK 218
Query: 52 RGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGE 111
GQLG +P +++L + + + CG++H+ A+ +G VF +GAG GQLG
Sbjct: 219 FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278
Query: 112 FKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDS-QVFSWGKNSHGQLGLG 163
P+K+ L + +++CG H+ A S +++S+G +GQLG G
Sbjct: 279 TSH-EINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 226 bits (576), Expect = 8e-59
Identities = 147/454 (32%), Positives = 246/454 (54%), Gaps = 26/454 (5%)
Query: 572 VNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLS 631
V +CR P F +N ++ ++ +D ET + F PFI N+++
Sbjct: 431 VKTLDCRKPLIPFE-----EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT 485
Query: 632 KIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQL-- 689
K L D+ I+M SE++ +L +++Q + +P L+VRR ++ DAL +L
Sbjct: 486 KNLGLYYDNRIRMY-SERRITVLY--SLVQGQQL---NPYLRLKVRRDHIIDDALVRLEM 539
Query: 690 -SQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFP 748
+ D K L VEF E + GGVS EFF + EE+ P+ GMF Y E WF
Sbjct: 540 IAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFN 599
Query: 749 AKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808
+ ++ L G++ GL+++N + ++ FP+ +Y+KL+ +K + DL + P L +SL
Sbjct: 600 PSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL 659
Query: 809 QEVLDDAADDIGDALCIRFSIHWDQNDV-------DLIPNGISIPVDQTNKRDYVSKYID 861
+++L + ++ D + I F I Q D+ DL NG IP+ N++++V+ Y D
Sbjct: 660 KDLL-EYEGNVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD 716
Query: 862 YIFNVSVKAVYEEFQRGFYRVCEKEILRH-FYPEELMTAIIGNTDYDWKQFEQNSKYEQG 920
YI N SV+ ++ F+RGF+ V + L++ F PEE+ I G+ + D++ E+ ++Y+ G
Sbjct: 717 YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGG 776
Query: 921 YQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHP 980
Y + I+ FW+ H T ++K+ FL F TG DR G+ K++++ +ER P
Sbjct: 777 YTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER-LP 835
Query: 981 TSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
TS TC N+L LP+YS+ E+++E L AI +GF
Sbjct: 836 TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 226 bits (576), Expect = 8e-59
Identities = 147/454 (32%), Positives = 246/454 (54%), Gaps = 26/454 (5%)
Query: 572 VNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLS 631
V +CR P F +N ++ ++ +D ET + F PFI N+++
Sbjct: 411 VKTLDCRKPLIPFE-----EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT 465
Query: 632 KIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQL-- 689
K L D+ I+M SE++ +L +++Q + +P L+VRR ++ DAL +L
Sbjct: 466 KNLGLYYDNRIRMY-SERRITVLY--SLVQGQQL---NPYLRLKVRRDHIIDDALVRLEM 519
Query: 690 -SQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFP 748
+ D K L VEF E + GGVS EFF + EE+ P+ GMF Y E WF
Sbjct: 520 IAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFN 579
Query: 749 AKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808
+ ++ L G++ GL+++N + ++ FP+ +Y+KL+ +K + DL + P L +SL
Sbjct: 580 PSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL 639
Query: 809 QEVLDDAADDIGDALCIRFSIHWDQNDV-------DLIPNGISIPVDQTNKRDYVSKYID 861
+++L + ++ D + I F I Q D+ DL NG IP+ N++++V+ Y D
Sbjct: 640 KDLL-EYEGNVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD 696
Query: 862 YIFNVSVKAVYEEFQRGFYRVCEKEILRH-FYPEELMTAIIGNTDYDWKQFEQNSKYEQG 920
YI N SV+ ++ F+RGF+ V + L++ F PEE+ I G+ + D++ E+ ++Y+ G
Sbjct: 697 YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGG 756
Query: 921 YQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHP 980
Y + I+ FW+ H T ++K+ FL F TG DR G+ K++++ +ER P
Sbjct: 757 YTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER-LP 815
Query: 981 TSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
TS TC N+L LP+YS+ E+++E L AI +GF
Sbjct: 816 TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 226 bits (576), Expect = 8e-59
Identities = 147/454 (32%), Positives = 246/454 (54%), Gaps = 26/454 (5%)
Query: 572 VNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLS 631
V +CR P F +N ++ ++ +D ET + F PFI N+++
Sbjct: 434 VKTLDCRKPLIPFE-----EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT 488
Query: 632 KIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQL-- 689
K L D+ I+M SE++ +L +++Q + +P L+VRR ++ DAL +L
Sbjct: 489 KNLGLYYDNRIRMY-SERRITVLY--SLVQGQQL---NPYLRLKVRRDHIIDDALVRLEM 542
Query: 690 -SQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFP 748
+ D K L VEF E + GGVS EFF + EE+ P+ GMF Y E WF
Sbjct: 543 IAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFN 602
Query: 749 AKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808
+ ++ L G++ GL+++N + ++ FP+ +Y+KL+ +K + DL + P L +SL
Sbjct: 603 PSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL 662
Query: 809 QEVLDDAADDIGDALCIRFSIHWDQNDV-------DLIPNGISIPVDQTNKRDYVSKYID 861
+++L + ++ D + I F I Q D+ DL NG IP+ N++++V+ Y D
Sbjct: 663 KDLL-EYEGNVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD 719
Query: 862 YIFNVSVKAVYEEFQRGFYRVCEKEILRH-FYPEELMTAIIGNTDYDWKQFEQNSKYEQG 920
YI N SV+ ++ F+RGF+ V + L++ F PEE+ I G+ + D++ E+ ++Y+ G
Sbjct: 720 YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGG 779
Query: 921 YQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHP 980
Y + I+ FW+ H T ++K+ FL F TG DR G+ K++++ +ER P
Sbjct: 780 YTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER-LP 838
Query: 981 TSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
TS TC N+L LP+YS+ E+++E L AI +GF
Sbjct: 839 TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 179 bits (453), Expect = 2e-44
Identities = 121/417 (29%), Positives = 203/417 (48%), Gaps = 33/417 (7%)
Query: 620 FSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFIL----R 675
F +PF+ + +K ++Q DS E++ + ++++ K IL +
Sbjct: 368 FCQYPFVISVAAKKIIIQRDS-------EQQMINIARQSLVDKVSRRQRPDMNILFLNMK 420
Query: 676 VRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGM 735
VRR+ LV D+L +L++ A D K L V F+ E + GG++ E+F + ++ P+YGM
Sbjct: 421 VRRTHLVSDSLDELTRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGM 479
Query: 736 FMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLL------- 788
F Y + C WF + + L G+L GL+++N ++ FP YKKLL
Sbjct: 480 FTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPS 539
Query: 789 DQ-------KPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQ----NDVD 837
DQ +++DL ++ P L L E+L ++ + F + ++ +
Sbjct: 540 DQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEG-NVEEDFYSTFQVFQEEFGIIKSYN 598
Query: 838 LIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELM 897
L P G I V N+++YV Y D++ N S+ + F GF+ VC L PEE+
Sbjct: 599 LKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVE 658
Query: 898 TAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 957
+ G+ D D +++++Y+ GY K+ TI+ FW LD +KK L F TG DR+
Sbjct: 659 ILVCGSPDLDMHALQRSTQYD-GYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVP 717
Query: 958 ARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
G+ + ET S P + TC N L LP Y + + +++ L + I+N+ GF
Sbjct: 718 VGGMADLNFKISKNET-STNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGF 773
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 154 bits (389), Expect = 4e-37
Identities = 91/276 (32%), Positives = 140/276 (50%), Gaps = 8/276 (2%)
Query: 30 SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLA 89
SG RH+ L + +V S G+ G+LG + P I+AL+T + ++CG HS A
Sbjct: 3054 SGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAA 3113
Query: 90 VCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCG--HYHSLALSKDS 147
+ G ++ WG G G+LG G+ PK + L ++IQV+CG +LAL+ +
Sbjct: 3114 LTSSGELYTWGLGEYGRLGHGD-NTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG 3172
Query: 148 QVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS 207
VFSWG G+LG G PQ + L G + Q+ G S AL+ G + WG
Sbjct: 3173 LVFSWGDGDFGKLGRGGSEGCNI-PQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
Query: 208 NSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
+L G V KP V L+ +V+++ G H +T G+V+ +GDN GQ
Sbjct: 3232 GDYFRL---GHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQ 3288
Query: 268 LGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAY 302
G T R P LV+ ++G ++++ CGS H++A+
Sbjct: 3289 QGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAW 3324
Score = 148 bits (373), Expect = 3e-35
Identities = 101/283 (35%), Positives = 149/283 (52%), Gaps = 17/283 (6%)
Query: 48 GDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQL 107
G N RGQLG + ++P P +AL TL + G++ AV G+++A G G+ G+L
Sbjct: 3958 GHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRL 4017
Query: 108 GIGEFKEISFTPKKIMTLND--IKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE 165
GIG + +S TP + ++ IK + V+ G H LALS + +V+SWG+ G+LG G
Sbjct: 4018 GIGGTESVS-TPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNR 4076
Query: 166 FPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSN 225
P P+ + SL GI + VAAGGAHS ++ G + WG G+L G +
Sbjct: 4077 SPCD-RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRL---GHSDSEDQL 4132
Query: 226 KPLSVGALKNLGVVYISC--GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVE 283
KP V AL+ VV I+C GDA T LT D V+++GD G+LG + + P ++
Sbjct: 4133 KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKID 4192
Query: 284 RIDGL-VSQIDCGSYHTLA-------YVHTTGQVVSFGHGPSD 318
+ GL V +++CGS ++A Y G GHG D
Sbjct: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDD 4235
Score = 144 bits (364), Expect = 3e-34
Identities = 94/291 (32%), Positives = 145/291 (49%), Gaps = 10/291 (3%)
Query: 30 SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLA 89
SG +H L L + V S G+ G+LG + P I++L + V V+ G HS
Sbjct: 4046 SGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSAC 4105
Query: 90 VCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGH--YHSLALSKDS 147
V G ++ WG G G+LG + E PK + L +++ ++CG +L L+ D
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSD-SEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDD 4164
Query: 148 QVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS 207
V+SWG +G+LG G + P ++ SL G+ + +V G S AL+ G + WG
Sbjct: 4165 TVWSWGDGDYGKLGRGGSDGCKV-PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGK 4223
Query: 208 NSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
+L G +P V L+ V+ I+ G H T+DG+V+T+GDN GQ
Sbjct: 4224 GDYHRL---GHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQ 4280
Query: 268 LGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFGHGPS 317
LG T + P+LV + G V+++ CGS HTLA+ +T + S G P+
Sbjct: 4281 LGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAW--STSKPASAGKLPA 4329
Score = 130 bits (326), Expect = 8e-30
Identities = 95/302 (31%), Positives = 154/302 (50%), Gaps = 12/302 (3%)
Query: 19 GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVD 78
G+ G+ + + A+G + + T +V G N + QLG + ++P + L L V
Sbjct: 2938 GNSGSLIRKKAAGLESAATIRT--KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVV 2995
Query: 79 LVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLND--IKIIQVSCG 136
V+ G + AV +G+V+A G + G+LG+G P++I L+ +K + V G
Sbjct: 2996 QVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSG 3055
Query: 137 HYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
H+ AL+ D +VFSWG+ G+LG P+ + +L+ + +A G +HS AL
Sbjct: 3056 GRHATALTVDGKVFSWGEGDDGKLGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAAL 3114
Query: 197 SLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG--DAHTAVLTQD 254
+ G + WG G+L G KP V L V+ ++CG DA T LT +
Sbjct: 3115 TSSGELYTWGLGEYGRL---GHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDE 3171
Query: 255 GKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFG 313
G VF++GD G+LG + PQ +ER++G V QI+CG+ +LA + +G V ++G
Sbjct: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLA-LTKSGVVWTWG 3230
Query: 314 HG 315
G
Sbjct: 3231 KG 3232
Score = 124 bits (310), Expect = 6e-28
Identities = 80/293 (27%), Positives = 147/293 (50%), Gaps = 11/293 (3%)
Query: 26 LQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVD--LVSCG 83
+Q GE+ + + ++ + G + G+LG G + P +++++ + + V+ G
Sbjct: 3988 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSG 4047
Query: 84 KEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
+H LA+ +G V++WG +G+LG G + P+ I +L I+++ V+ G HS +
Sbjct: 4048 GKHCLALSSEGEVYSWGEAEDGKLGHGN-RSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106
Query: 144 SKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLCGT 201
+ +++WGK +G+LG + Q P+ V +L+G + +A +G A + L+ T
Sbjct: 4107 TAAGDLYTWGKGRYGRLG-HSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
Query: 202 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
+ WG G+L GR P+ + +L LGVV + CG + LT+ G V+T+G
Sbjct: 4166 VWSWGDGDYGKL---GRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWG 4222
Query: 262 DNRSGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFG 313
+LG+ R P+ V+ + G V I GS H + G+V ++G
Sbjct: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTE-DGEVYTWG 4274
Score = 119 bits (298), Expect = 1e-26
Identities = 88/313 (28%), Positives = 153/313 (48%), Gaps = 29/313 (9%)
Query: 27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE- 85
Q A E+ L+L N RV + NS P+ +Q L + + ++ +
Sbjct: 455 QIACAEKRFLILSRNGRVYTQAYNSDTLA----------PQLVQGLASRNIVKIAAHSDG 504
Query: 86 -HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK----IIQVSCGHYHS 140
H LA+ G V++WG G G+LG G+ + PK I + + ++ ++CG +S
Sbjct: 505 HHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQAGKHVVHIACGSTYS 563
Query: 141 LALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG--AHSFALSL 198
A++ + ++++WG+ ++G+LG G +A P V L+G+ + VA G A + A++
Sbjct: 564 AAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTE 622
Query: 199 CGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVF 258
G + WG G+L G + P + L++L VV + CG + LT+DG+V+
Sbjct: 623 NGQVWSWGDGDYGKLGRGGSD---GCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVY 679
Query: 259 TFGDNRSGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFGHGPS 317
++G + +LG+ R P+L+E + G V + GS H LA + +V S+G
Sbjct: 680 SWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS-EVHSWGSNDQ 738
Query: 318 ----DTSKPTHPE 326
DT + T PE
Sbjct: 739 CQHFDTLRVTKPE 751
Score = 112 bits (281), Expect = 1e-24
Identities = 74/229 (32%), Positives = 115/229 (50%), Gaps = 7/229 (3%)
Query: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
G ++ A G +S + + + G + G+LG ++ +P + L+ L V V+
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
Query: 82 CGK--EHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
CG +LAV G+V++WG G G+LG G + TPK I L D+ +++V CG
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG-SDGCKTPKLIEKLQDLDVVKVRCGSQF 668
Query: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
S+AL+KD QV+SWGK + +LG G E P+ + L+G + VAAG H AL+
Sbjct: 669 SIALTKDGQVYSWGKGDNQRLGHGTE-EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED 727
Query: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
WGSN Q + V +P ++ L +V I+CG A +
Sbjct: 728 SEVHSWGSNDQCQ---HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQS 773
Score = 109 bits (273), Expect = 1e-23
Identities = 71/226 (31%), Positives = 108/226 (47%), Gaps = 7/226 (3%)
Query: 29 ASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE--H 86
A G HS L ++ + + G G+LG P+ ++ L V V+CG
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQ 3164
Query: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
+LA+ +G VF+WG G G+LG G + + P+ I LN + Q+ CG SLAL+K
Sbjct: 3165 TLALTDEGLVFSWGDGDFGKLGRGGSEGCNI-PQNIERLNGQGVCQIECGAQFSLALTKS 3223
Query: 147 SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWG 206
V++WGK + +LG G + + PQ V L G + VA G H A++ G + WG
Sbjct: 3224 GVVWTWGKGDYFRLGHGSDVHVR-KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3282
Query: 207 SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLT 252
N GQ G + KP V L+ + ++CG +H+ T
Sbjct: 3283 DNDHGQ---QGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325
Score = 107 bits (268), Expect = 4e-23
Identities = 69/229 (30%), Positives = 115/229 (50%), Gaps = 7/229 (3%)
Query: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
G E++ A+G HS + + + G G+LG ++ P+ ++AL+ V ++
Sbjct: 4090 GIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIA 4149
Query: 82 CGKEHSLAVC--HKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
CG + +C V++WG G G+LG G + P KI +L + +++V CG
Sbjct: 4150 CGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGG-SDGCKVPMKIDSLTGLGVVKVECGSQF 4208
Query: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
S+AL+K V++WGK + +LG G + P++V+ L+G + +A G H +
Sbjct: 4209 SVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCTED 4267
Query: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
G + WG N GQL G +Q +P V AL+ V ++CG AHT
Sbjct: 4268 GEVYTWGDNDEGQLG-DGTTNAIQ--RPRLVAALQGKKVNRVACGSAHT 4313
Score = 103 bits (258), Expect = 6e-22
Identities = 65/212 (30%), Positives = 106/212 (50%), Gaps = 13/212 (6%)
Query: 26 LQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE 85
+ SG+ +L L + V S GD G+LGR G+ ++P I +L L V V CG +
Sbjct: 4148 IACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQ 4207
Query: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSK 145
S+A+ G V+ WG G +LG G + P+++ L K+I ++ G H + ++
Sbjct: 4208 FSVALTKSGAVYTWGKGDYHRLGHGSDDHVR-RPRQVQGLQGKKVIAIATGSLHCVCCTE 4266
Query: 146 DSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGW 205
D +V++WG N GQLG G Q P+ V +L+G + +VA G AH+ A W
Sbjct: 4267 DGEVYTWGDNDEGQLGDGTTNAIQ-RPRLVAALQGKKVNRVACGSAHTLA---------W 4316
Query: 206 GSNSAGQLALSGRNVPVQSN--KPLSVGALKN 235
++ VP++ N + + + AL+N
Sbjct: 4317 STSKPASAGKLPAQVPMEYNHLQEIPIIALRN 4348
Score = 103 bits (257), Expect = 8e-22
Identities = 77/260 (29%), Positives = 129/260 (49%), Gaps = 27/260 (10%)
Query: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTL 125
P + L L V ++C ++ L + GRV+ S+ + P+ + L
Sbjct: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490
Query: 126 ---NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP 182
N +KI S GH H LAL+ +V+SWG G+LG G P + P+ + + G
Sbjct: 491 ASRNIVKIAAHSDGH-HYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQ 548
Query: 183 ----LAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGV 238
+ +A G +S A++ G + WG + G+L G P+ V LK L V
Sbjct: 549 AGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRL---GHGSSEDEAIPMLVAGLKGLKV 605
Query: 239 VYISC--GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCG 295
+ ++C GDA T +T++G+V+++GD G+LG + + P+L+E++ L V ++ CG
Sbjct: 606 IDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCG 665
Query: 296 SYHTLAYVHTTGQVVSFGHG 315
S ++A + GQV S+G G
Sbjct: 666 SQFSIA-LTKDGQVYSWGKG 684
Score = 102 bits (255), Expect = 1e-21
Identities = 66/196 (33%), Positives = 102/196 (52%), Gaps = 4/196 (2%)
Query: 6 GADSRELQRRRTAGSPGAELLQAA--SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRG 63
G+ E AG G +++ A SG+ +L + N +V S GD G+LGR G+
Sbjct: 586 GSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 645
Query: 64 ELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIM 123
+ P+ I+ L+ L V V CG + S+A+ G+V++WG G +LG G + + + PK +
Sbjct: 646 KTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRY-PKLLE 704
Query: 124 TLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 183
L K+I V+ G H LAL++DS+V SWG N Q ++ P + L+ +
Sbjct: 705 GLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-HFDTLRVTKPEPAALPGLDTKHI 763
Query: 184 AQVAAGGAHSFALSLC 199
+A G A SFA S C
Sbjct: 764 VGIACGPAQSFAWSSC 779
Score = 100 bits (249), Expect = 7e-21
Identities = 64/213 (30%), Positives = 115/213 (53%), Gaps = 8/213 (3%)
Query: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
+L+ G ++ WG GQLG E ++ P L ++ +Q+ G A++ D
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVK-VPTPCEALATLRPVQLIGGEQTLFAVTAD 4003
Query: 147 SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLCGTSFG 204
++++ G + G+LG+G S ++P + S++ + + +VA +GG H ALS G +
Sbjct: 4004 GKLYATGYGAGGRLGIGGT-ESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 4062
Query: 205 WGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNR 264
WG G+L R+ ++P + +L+ + VV ++ G AH+A +T G ++T+G R
Sbjct: 4063 WGEAEDGKLGHGNRS---PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGR 4119
Query: 265 SGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGS 296
G+LG+S + ++ P+LVE + G V I CGS
Sbjct: 4120 YGRLGHSDSEDQLKPKLVEALQGHRVVDIACGS 4152
Score = 89.4 bits (220), Expect = 2e-17
Identities = 71/234 (30%), Positives = 115/234 (49%), Gaps = 29/234 (12%)
Query: 92 HKG---RVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQ 148
HKG V WG +G + + P + L ++ + Q++C L LS++ +
Sbjct: 418 HKGSLQEVIGWGL-----IGWKYYANV-IGPIQCEGLANLGVTQIACAEKRFLILSRNGR 471
Query: 149 VFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAA--GGAHSFALSLCGTSFGWG 206
V++ NS +PQ V+ L + ++AA G H AL+ G + WG
Sbjct: 472 VYTQAYNS-----------DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWG 520
Query: 207 SNSAGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISCGDAHTAVLTQDGKVFTFGDNR 264
G+L G VP++ K +S + K G VV+I+CG ++A +T +G+++T+G
Sbjct: 521 CGDGGRLG-HGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGN 579
Query: 265 SGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGS--YHTLAYVHTTGQVVSFGHG 315
G+LG+ + ++ P LV + GL V + CGS TLA V GQV S+G G
Sbjct: 580 YGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLA-VTENGQVWSWGDG 632
Score = 81.3 bits (199), Expect = 4e-15
Identities = 87/330 (26%), Positives = 145/330 (43%), Gaps = 26/330 (7%)
Query: 699 KVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG--------SC-MWFPA 749
+V V+F+ E + GG SE + EE+ + + G C + PA
Sbjct: 4464 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPA 4523
Query: 750 KPKPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808
P F F G+L G+++ + +L ++K+L ++ DL E+ L
Sbjct: 4524 ARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGL 4583
Query: 809 QEVLD-DAADDIGDALCIRFSI-HWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYI--- 863
+ D +A + +A+ + F++ D+ L I +D N+ +YV I+Y
Sbjct: 4584 MYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLD--NRAEYVRLAINYRLHE 4641
Query: 864 FNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQK 923
F+ V AV E G RV +L F EL T + G+ D + + Y+ G +
Sbjct: 4642 FDEQVAAVRE----GMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYK-GIEP 4696
Query: 924 SHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHAR--GIQKMEIVFRCPETFSERDH-- 979
S IQ FW+ + E+ FL F+ GR RL + + V + + ++ DH
Sbjct: 4697 SASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFL 4756
Query: 980 PTSITCHNILSLPKYSTMERMEEALQVAIN 1009
P S TC +L LP+YS + +EE L+ AI+
Sbjct: 4757 PESYTCFFLLKLPRYSCKQVLEEKLKYAIH 4786
Score = 58.5 bits (140), Expect = 3e-08
Identities = 42/162 (25%), Positives = 67/162 (41%), Gaps = 14/162 (8%)
Query: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
G +++ G + S+ L + V + G +LG P +Q L+ V ++
Sbjct: 4196 GLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIA 4255
Query: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
G H + G V+ WG EGQLG G I P+ + L K+ +V+CG H+L
Sbjct: 4256 TGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQ-RPRLVAALQGKKVNRVACGSAHTL 4314
Query: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 183
A W + G + P+Q P L+ IP+
Sbjct: 4315 A---------WSTSKPASAG---KLPAQV-PMEYNHLQEIPI 4343
Score = 54.3 bits (129), Expect = 6e-07
Identities = 37/121 (30%), Positives = 55/121 (45%), Gaps = 1/121 (0%)
Query: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
G + Q G + SL L + V + G +LG P+ ++ L + V+
Sbjct: 3204 GQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVA 3263
Query: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
G H LAV G+V+AWG GQ G G ++ P + L KI +V+CG HS+
Sbjct: 3264 VGALHCLAVTDSGQVYAWGDNDHGQQGNGT-TTVNRKPTLVQGLEGQKITRVACGSSHSV 3322
Query: 142 A 142
A
Sbjct: 3323 A 3323
Score = 48.1 bits (113), Expect = 4e-05
Identities = 26/84 (30%), Positives = 42/84 (50%)
Query: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
G+D + R+ G G +++ A+G H + + V + GDN GQLG +
Sbjct: 4232 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR 4291
Query: 66 PEPIQALETLIVDLVSCGKEHSLA 89
P + AL+ V+ V+CG H+LA
Sbjct: 4292 PRLVAALQGKKVNRVACGSAHTLA 4315
Score = 44.3 bits (103), Expect = 6e-04
Identities = 25/84 (29%), Positives = 39/84 (46%)
Query: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
G+D + + G G +++ A G H L + + +V + GDN GQ G
Sbjct: 3240 GSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRK 3299
Query: 66 PEPIQALETLIVDLVSCGKEHSLA 89
P +Q LE + V+CG HS+A
Sbjct: 3300 PTLVQGLEGQKITRVACGSSHSVA 3323
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 487 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 544
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 545 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 597
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 657
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 658 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 717
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 718 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 777
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 778 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 837
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 838 EKLLMAVENAQGF 850
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 588 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 645
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 646 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 698
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 699 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 758
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 759 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 818
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 819 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 878
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 879 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 938
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 939 EKLLMAVENAQGF 951
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 467 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 524
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 525 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 577
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 578 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 637
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 638 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 697
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 698 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 757
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 758 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 817
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 818 EKLLMAVENAQGF 830
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 467 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 524
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 525 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 577
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 578 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 637
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 638 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 697
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 698 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 757
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 758 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 817
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 818 EKLLMAVENAQGF 830
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 580 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 637
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 638 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 690
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 691 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 750
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 751 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 810
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 811 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 870
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 871 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 930
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 931 EKLLMAVENAQGF 943
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 600 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 657
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 658 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 710
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 711 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 770
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 771 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 830
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 831 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 890
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 891 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 950
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 951 EKLLMAVENAQGF 963
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 608 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 665
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 666 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 718
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 719 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 778
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 779 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 838
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 839 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 898
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 899 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 958
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 959 EKLLMAVENAQGF 971
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 487 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 544
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 545 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 597
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 657
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 658 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 717
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 718 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 777
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 778 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 837
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 838 EKLLMAVENAQGF 850
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 152 bits (385), Expect = 1e-36
Identities = 107/373 (28%), Positives = 178/373 (47%), Gaps = 27/373 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K + P RF +++ R+ + +++ R++ + D K L +EF +E + GGV+
Sbjct: 487 LKKPADIPN--RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 544
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 545 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFTFIGRVAG 597
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
L++F+ + + F YK +L ++ +L D++ + SL+ +L++ ++ CI
Sbjct: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID 657
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
VDL PNG I V NKR+Y+ I + F V+ F GF + +
Sbjct: 658 EENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPID 717
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + Q+S Y+ GY +HP IQ FWKA + +++ +
Sbjct: 718 LIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRL 777
Query: 947 LFFLTGRDRLHARGIQKM-----EIVFRCPETFSERDHPTSITCHNILSLPKYSTMERME 1001
L F+TG R+ G ++ +F + S P + TC N L LP Y T E +
Sbjct: 778 LQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLR 837
Query: 1002 EALQVAINNNRGF 1014
E L +A+ N +GF
Sbjct: 838 EKLLMAVENAQGF 850
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 150 bits (378), Expect = 8e-36
Identities = 110/391 (28%), Positives = 190/391 (48%), Gaps = 18/391 (4%)
Query: 27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVD--LVSCGK 84
Q G+ + ++ N VL+CG+ S G+LG+ + + I AL+ +V + SCG
Sbjct: 4031 QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS 4090
Query: 85 E-HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
+ HS+A+ G VF+WG G G+LG G + P++I L +++Q+SCG HS +
Sbjct: 4091 DGHSMALTESGEVFSWGDGDYGKLGHGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSAVV 4149
Query: 144 SKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS- 202
+ D ++F++G +G+LGLG ++ P+RV +LEG + QVA G H+ A+S G+
Sbjct: 4150 TSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMV 4208
Query: 203 FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGD 262
+ +G G+L L + P + L +G+ ++CG + LT+DG V+TFG
Sbjct: 4209 WAFGDGDYGKLGLGNSTA---KSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ 4265
Query: 263 NRSGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSK 321
+R L PQ + + G ++ + G+ HTLA + + G V ++G
Sbjct: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLA-LASNGDVYAWGSNSEGQLG 4324
Query: 322 PTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISR 381
H + E ++ L V+ I AG + T RAPG ++P
Sbjct: 4325 LGHTNHVREPTLVTGLQGK------NVRQISAGRCHSAAWTAPPV-PPRAPGVSVPLQLG 4377
Query: 382 ISQSMAEKWIAVKRRSTEHEMAKSEIRMIFS 412
+ ++ ++ A++ S A+ + FS
Sbjct: 4378 LPDTVPPQYGALREVSIHTVRARLRLLYHFS 4408
Score = 143 bits (360), Expect = 9e-34
Identities = 95/281 (33%), Positives = 147/281 (52%), Gaps = 7/281 (2%)
Query: 24 ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCG 83
+L+ + + HS+ L + V S GD G+LG + R P I+AL+ V +SCG
Sbjct: 4083 QLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 4142
Query: 84 KEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
+HS V G++F +G G G+LG+G P+++ L +I QV+CG H+LA+
Sbjct: 4143 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAV 4201
Query: 144 SKD-SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202
S D S V+++G +G+LGLG +++SPQ++ L GI + +VA G S AL+ G
Sbjct: 4202 SADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV 4260
Query: 203 FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGD 262
+ +G + L GR N+P + L + + ++ G HT L +G V+ +G
Sbjct: 4261 YTFGQDRLIGLP-EGR--ARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGS 4317
Query: 263 NRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302
N GQLG T R P LV + G V QI G H+ A+
Sbjct: 4318 NSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAW 4358
Score = 130 bits (326), Expect = 8e-30
Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 12/273 (4%)
Query: 34 HSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQA-LETLIVDLVSCGKEHSLAVCH 92
H+L T V S GD G+LG + + P+ IQ L+ +V VS G HS AV
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTE 528
Query: 93 KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQ-VFS 151
G ++ WG G G+LG G+ + P + ++++ +VSCG H++ALSKD + V+S
Sbjct: 529 DGELYTWGEGDFGRLGHGDSNSRNI-PTLVKDISNVG--EVSCGSSHTIALSKDGRTVWS 585
Query: 152 WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAG 211
+G +G+LG G + P+ + +L+G+ + +V AG S AL+ G + WG +
Sbjct: 586 FGGGDNGKLGHG-DTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGA-- 642
Query: 212 QLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY- 270
L + + +P + L +V +S GD+H L+ D +V+ +G+N GQ G
Sbjct: 643 --CLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQG 700
Query: 271 SPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302
+ T P+ V +DG+ + QI G+ H+LA+
Sbjct: 701 NSTGPITKPKKVSGLDGIAIQQISAGTSHSLAW 733
Score = 129 bits (325), Expect = 1e-29
Identities = 85/248 (34%), Positives = 133/248 (53%), Gaps = 6/248 (2%)
Query: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
G R+ + R+ G E++Q + G +HS ++ ++ ++ + G+ G+LG +L
Sbjct: 4117 GNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL 4176
Query: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKG-RVFAWGAGSEGQLGIGEFKEISFTPKKIMT 124
PE + ALE + V+CG H+LAV G V+A+G G G+LG+G S +P+KI
Sbjct: 4177 PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS-SPQKIDV 4235
Query: 125 LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184
L I I +V+CG S+AL+KD V+++G++ L G+ + PQ++ L G+ +
Sbjct: 4236 LCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVIIE 4294
Query: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244
VA G H+ AL+ G + WGSNS GQL L N +P V L+ V IS G
Sbjct: 4295 DVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTN---HVREPTLVTGLQGKNVRQISAG 4351
Query: 245 DAHTAVLT 252
H+A T
Sbjct: 4352 RCHSAAWT 4359
Score = 114 bits (285), Expect = 5e-25
Identities = 109/376 (28%), Positives = 182/376 (48%), Gaps = 41/376 (10%)
Query: 48 GDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQL 107
G NS QL G Q ++ +P A + G+ + + G V A G GS G+L
Sbjct: 378 GSNSSHQLVE-GTQE-KILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRL 435
Query: 108 GIGE------FKEISFTPKKIMTLNDIKIIQVSCGHY-HSLALSKDSQVFSWGKNSHGQL 160
G+G+ K+++F P + IK + S G H+LA + + +VFSWG +G+L
Sbjct: 436 GLGDSNNQSTLKKLTFEPHR-----SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKL 490
Query: 161 GLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRN 219
G G +Q P+ ++ L+G + V+AG HS A++ G + WG G+L N
Sbjct: 491 GHGNS-STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
Query: 220 VPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGK-VFTFGDNRSGQLGYSPTPEKRG 278
N P V + N+G V SCG +HT L++DG+ V++FG +G+LG+ T
Sbjct: 550 ---SRNIPTLVKDISNVGEV--SCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYK 604
Query: 279 PQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFGHGP-----SDTSKPTHPEALTENF 332
P+++E + G+ + ++ GS +LA +TGQV ++G G S + P+ + E
Sbjct: 605 PKVIEALQGMFIRKVCAGSQSSLALT-STGQVYAWGCGACLGCGSSEATALRPKLIEE-- 661
Query: 333 DISCLISAEDFVDVQV--KHIFAGTYANFVTTHQDTSSTR-APGKTLPEISRISQSMAEK 389
++A VDV + H A ++ N V + S + G + I++ +
Sbjct: 662 -----LAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLD 716
Query: 390 WIAVKRRS--TEHEMA 403
IA+++ S T H +A
Sbjct: 717 GIAIQQISAGTSHSLA 732
Score = 111 bits (278), Expect = 3e-24
Identities = 63/170 (37%), Positives = 94/170 (55%), Gaps = 3/170 (1%)
Query: 27 QAASGERHSLLLLTNHR-VLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE 85
+ + G H++ L + R V S G G+LG R P+ I+AL+ + + V G +
Sbjct: 565 EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ 624
Query: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSK 145
SLA+ G+V+AWG G+ LG G + + PK I L +I+ VS G H LALS
Sbjct: 625 SSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH 682
Query: 146 DSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 195
D++V++WG NS GQ G G P++V L+GI + Q++AG +HS A
Sbjct: 683 DNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732
Score = 109 bits (272), Expect = 2e-23
Identities = 73/224 (32%), Positives = 108/224 (48%), Gaps = 12/224 (5%)
Query: 96 VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKN 155
V+ WGAG GQL E P + + + QV CG + + + V + G+
Sbjct: 3999 VYLWGAGRHGQL--AEAGRNVMVPAAAPSFSQAQ--QVICGQNCTFVIQANGTVLACGEG 4054
Query: 156 SHGQLGLGKEFPSQASPQRVRSLEGIPLAQV---AAGGAHSFALSLCGTSFGWGSNSAGQ 212
S+G+LG G + +L+G + Q+ HS AL+ G F WG G+
Sbjct: 4055 SYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 4113
Query: 213 LALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSP 272
L G + +P + AL+ VV +SCG H+AV+T DGK+FTFG+ G+LG
Sbjct: 4114 L---GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 4170
Query: 273 TPEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFGHG 315
T K+ P+ V ++G + Q+ CG HTLA V +FG G
Sbjct: 4171 TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 4214
Score = 106 bits (264), Expect = 1e-22
Identities = 68/232 (29%), Positives = 112/232 (48%), Gaps = 8/232 (3%)
Query: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
G ++ ++G RHS + + + + G+ G+LG + +P ++ + V VS
Sbjct: 510 GKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGEVS 567
Query: 82 CGKEHSLAVCHKGR-VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHS 140
CG H++A+ GR V+++G G G+LG G+ + + PK I L + I +V G S
Sbjct: 568 CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRV-YKPKVIEALQGMFIRKVCAGSQSS 626
Query: 141 LALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCG 200
LAL+ QV++WG + LG G + P+ + L + V+ G +H ALS
Sbjct: 627 LALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684
Query: 201 TSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLT 252
+ WG+NS GQ P+ KP V L + + IS G +H+ T
Sbjct: 685 EVYAWGNNSMGQCGQGNSTGPI--TKPKKVSGLDGIAIQQISAGTSHSLAWT 734
Score = 103 bits (256), Expect = 1e-21
Identities = 75/244 (30%), Positives = 127/244 (52%), Gaps = 20/244 (8%)
Query: 96 VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKN 155
V+ WG+ S QL G ++I PK + +D + I+ G Y + +S D V + GK
Sbjct: 374 VYVWGSNSSHQLVEGTQEKI-LQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGKG 430
Query: 156 SHGQLGLGKEFPSQASPQRV-----RSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
S+G+LGLG + +Q++ +++ RS++ + ++ + G H+ A + G F WG
Sbjct: 431 SYGRLGLG-DSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFSWGDGDY 487
Query: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270
G+L N Q L G L+ VV +S G H+A +T+DG+++T+G+ G+LG+
Sbjct: 488 GKLGHG--NSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGH 545
Query: 271 SPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPS------DTSKPTH 324
+ + P LV+ I V ++ CGS HT+A V SFG G + DT++
Sbjct: 546 GDSNSRNIPTLVKDISN-VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYK 604
Query: 325 PEAL 328
P+ +
Sbjct: 605 PKVI 608
Score = 73.9 bits (180), Expect = 7e-13
Identities = 84/353 (23%), Positives = 153/353 (43%), Gaps = 36/353 (10%)
Query: 687 RQLSQAEATDF---CKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFM-----Y 738
RQ+ + A+D + V+ + E ++GGV + M +E+ + +
Sbjct: 4495 RQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNAT 4554
Query: 739 PEMG----SCMWFPAKPKPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPS 793
E+G ++ P+ E F F G+L G+++ +L ++K+L +
Sbjct: 4555 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLT 4614
Query: 794 LEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHW------------DQNDVDLIPN 841
LEDL+E+ ++L +L I D+ S H D V +IP
Sbjct: 4615 LEDLEEVDLLYVQTLNSILH-----IEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPG 4669
Query: 842 GISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAII 901
G SIP+ +N+++YV + I+Y + + V + G + +L ++L +
Sbjct: 4670 GNSIPLTFSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVC 4728
Query: 902 GNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHAR-- 959
G + + ++ +Y + + H +Q FW + + +E+ F+ F++GR RL A
Sbjct: 4729 GMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTA 4787
Query: 960 GIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNR 1012
I + + + + PTS TC L LP YS+ M E L+ AINN R
Sbjct: 4788 DISQRFQIMKVDRPYDSL--PTSQTCFFQLRLPPYSSQLVMAERLRYAINNCR 4838
Score = 58.2 bits (139), Expect = 4e-08
Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 57/181 (31%)
Query: 205 WGSNSAGQLALSGRNVPVQSNKP----------------------------------LSV 230
WG+ GQLA +GRNV V + P L
Sbjct: 4002 WGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQ 4061
Query: 231 GALKNLGVVYI--------------SCG-DAHTAVLTQDGKVFTFGDNRSGQLGYSPTPE 275
G +L V+ + SCG D H+ LT+ G+VF++GD G+LG+ +
Sbjct: 4062 GNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDR 4121
Query: 276 KRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFGHGP------SDTSKPTHPEAL 328
+R P+ +E + G V Q+ CG H+ A V + G++ +FG+G +TS PE +
Sbjct: 4122 QRRPRQIEALQGEEVVQMSCGFKHS-AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV 4180
Query: 329 T 329
T
Sbjct: 4181 T 4181
Score = 40.8 bits (94), Expect = 0.007
Identities = 23/88 (26%), Positives = 44/88 (50%), Gaps = 3/88 (3%)
Query: 4 CWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRG 63
C +++ L+ + ++ + G+ H L L ++ V + G+NS GQ G +G G
Sbjct: 646 CGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCG-QGNSTG 704
Query: 64 EL--PEPIQALETLIVDLVSCGKEHSLA 89
+ P+ + L+ + + +S G HSLA
Sbjct: 705 PITKPKKVSGLDGIAIQQISAGTSHSLA 732
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 145 bits (365), Expect = 2e-34
Identities = 118/465 (25%), Positives = 224/465 (48%), Gaps = 30/465 (6%)
Query: 578 RLPENTFNIN--ELSNLLNFYIDR----GRQLFRDNHLIPAETPSPVIFSDFPFIFNSLS 631
R+P + NIN EL L + R GR F D++ + P + ++ + N +
Sbjct: 283 RVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQN 342
Query: 632 KIKLLQADSHIKM--------QMSEKKAYMLMHETILQKK--DEFPPSPRFILRVRRSRL 681
++K Q + + + K ++ IL+++ + P + + V R +
Sbjct: 343 QLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEI 402
Query: 682 VKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYP-- 739
+++ RQ+ + D K L+++F E + GGV+ E+ + + EM P YG+F Y
Sbjct: 403 FEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRD 462
Query: 740 EMGSCMWFP-AKPKPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDL 797
++ + P + PE YF F G + G+++F+ + + F L YK+LL + +L+D+
Sbjct: 463 DIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDM 522
Query: 798 KELSPRLGKSLQEVLDDAADDIGD-ALCIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYV 856
+ + P L SL +L++ + D C+ + + + +L PNG SIPV++ NK++YV
Sbjct: 523 ELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYV 582
Query: 857 SKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSK 916
Y+++ F ++A + Q+GF V + +L+ F +EL I G D ++ N++
Sbjct: 583 RLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTR 642
Query: 917 YEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFS- 975
+ S+ ++ FWKA + + + L F+TG R+ +G + ++ P F+
Sbjct: 643 LKHCTPDSN-IVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGA-AGPRLFTI 700
Query: 976 ------ERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
+ P + TC N + +P Y + E++ E L AI GF
Sbjct: 701 HQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 144 bits (363), Expect = 4e-34
Identities = 98/374 (26%), Positives = 184/374 (49%), Gaps = 29/374 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K+++ P +F +++RR+ +++D+ R++ + DF K L +EF E + GGV+
Sbjct: 533 LKKQNDIPN--KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAR 590
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 591 EWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFKFIGRVAG 643
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
+++++ + + F YK +L + +L D++ + SL+ +L++ ++ I
Sbjct: 644 MAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIID 703
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
+ + +L G I V NK++Y+ I + F ++ F+ GF+ + ++
Sbjct: 704 EELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQD 763
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + +++KY+ GY +H IQ FWKA + +++ +
Sbjct: 764 LIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRL 823
Query: 947 LFFLTGRDRLHARGIQKMEIVFRCPETFSERDH------PTSITCHNILSLPKYSTMERM 1000
L F+TG R+ G ++ P++F+ P + TC N L LP Y + E +
Sbjct: 824 LQFVTGTSRVPMNGFAEL-YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEEL 882
Query: 1001 EEALQVAINNNRGF 1014
+ LQ+AI N +GF
Sbjct: 883 WDKLQMAIENTQGF 896
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 144 bits (363), Expect = 4e-34
Identities = 98/374 (26%), Positives = 184/374 (49%), Gaps = 29/374 (7%)
Query: 660 LQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKV-LVVEFINEICPESGGVSS 718
L+K+++ P +F +++RR+ +++D+ R++ + DF K L +EF E + GGV+
Sbjct: 880 LKKQNDIPN--KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAR 937
Query: 719 EFFHCMFEEMTKPEYGMFMY-----------PEMGSCMWFPAKPKPEKKRYFLF-GMLCG 766
E+F + +EM P YG+F Y P G C + YF F G + G
Sbjct: 938 EWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLC-------NEDHLSYFKFIGRVAG 990
Query: 767 LSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIR 826
+++++ + + F YK +L + +L D++ + SL+ +L++ ++ I
Sbjct: 991 MAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIID 1050
Query: 827 FSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKE 886
+ + +L G I V NK++Y+ I + F ++ F+ GF+ + ++
Sbjct: 1051 EELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQD 1110
Query: 887 ILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 946
+++ F EL + G D D + +++KY+ GY +H IQ FWKA + +++ +
Sbjct: 1111 LIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRL 1170
Query: 947 LFFLTGRDRLHARGIQKMEIVFRCPETFSERDH------PTSITCHNILSLPKYSTMERM 1000
L F+TG R+ G ++ P++F+ P + TC N L LP Y + E +
Sbjct: 1171 LQFVTGTSRVPMNGFAEL-YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEEL 1229
Query: 1001 EEALQVAINNNRGF 1014
+ LQ+AI N +GF
Sbjct: 1230 WDKLQMAIENTQGF 1243
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 143 bits (361), Expect = 7e-34
Identities = 102/380 (26%), Positives = 185/380 (48%), Gaps = 19/380 (5%)
Query: 649 KKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINE 708
+K +L HE LQ+ P + + V R + +++ RQ+ + D K L+V+F E
Sbjct: 380 QKLKVLRHELSLQQ----PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGE 435
Query: 709 ICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWF---PAKPKPEKKRYFLF-GML 764
+ GGV+ E+ + + EM P YG+F Y M + P+ YF F G +
Sbjct: 436 EGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRI 495
Query: 765 CGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGD-AL 823
GL++F+ + N F + YK+LL + L DL+ + P L KSL +L++ + D
Sbjct: 496 MGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTF 555
Query: 824 CIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVC 883
C+ + +L PNG ++PV + NK++YV Y+++ F ++A + Q+GF +
Sbjct: 556 CVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELI 615
Query: 884 EKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEK 943
+ +L+ F +EL I G D ++ N++ + S+ ++ FW+A + +
Sbjct: 616 PQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERR 674
Query: 944 KKFLFFLTGRDRLHARGIQKME--------IVFRCPETFSERDH-PTSITCHNILSLPKY 994
+ L F+TG R+ +G + ++ +F + D+ P + TC N + +P Y
Sbjct: 675 ARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPY 734
Query: 995 STMERMEEALQVAINNNRGF 1014
+ E++ E L A+ GF
Sbjct: 735 ESYEKLYEKLLTAVEETCGF 754
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 143 bits (361), Expect = 7e-34
Identities = 102/380 (26%), Positives = 185/380 (48%), Gaps = 19/380 (5%)
Query: 649 KKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINE 708
+K +L HE LQ+ P + + V R + +++ RQ+ + D K L+V+F E
Sbjct: 354 QKLKVLRHELSLQQ----PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGE 409
Query: 709 ICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWF---PAKPKPEKKRYFLF-GML 764
+ GGV+ E+ + + EM P YG+F Y M + P+ YF F G +
Sbjct: 410 EGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRI 469
Query: 765 CGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGD-AL 823
GL++F+ + N F + YK+LL + L DL+ + P L KSL +L++ + D
Sbjct: 470 MGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTF 529
Query: 824 CIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVC 883
C+ + +L PNG ++PV + NK++YV Y+++ F ++A + Q+GF +
Sbjct: 530 CVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELI 589
Query: 884 EKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEK 943
+ +L+ F +EL I G D ++ N++ + S+ ++ FW+A + +
Sbjct: 590 PQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERR 648
Query: 944 KKFLFFLTGRDRLHARGIQKME--------IVFRCPETFSERDH-PTSITCHNILSLPKY 994
+ L F+TG R+ +G + ++ +F + D+ P + TC N + +P Y
Sbjct: 649 ARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPY 708
Query: 995 STMERMEEALQVAINNNRGF 1014
+ E++ E L A+ GF
Sbjct: 709 ESYEKLYEKLLTAVEETCGF 728
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 139 bits (349), Expect = 2e-32
Identities = 96/287 (33%), Positives = 151/287 (52%), Gaps = 9/287 (3%)
Query: 31 GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
G+ HS ++ N+++ G N+ GQLG P ++AL+ V L +CG+ H+L
Sbjct: 43 GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102
Query: 91 CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150
G V+A G +EGQLG+G+ +E + ++ KI Q+S G S AL++D ++F
Sbjct: 103 TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLF 162
Query: 151 SWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
WG NS GQ+GL K + PQ+V G P++ ++ G HS ++ G + +G
Sbjct: 163 MWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPEN 219
Query: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270
G+L L + + P V + V+ ++CG HT VLT++ V+TFG + GQLG
Sbjct: 220 GKLGLPNQLLG-NHRTPQLVSEIPE-KVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGL 276
Query: 271 SP-TPEKRGPQLVERI-DGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
E P+++E I D +S I CG HT A + G + +FG G
Sbjct: 277 GTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDG 322
Score = 119 bits (297), Expect = 2e-26
Identities = 83/238 (34%), Positives = 119/238 (50%), Gaps = 10/238 (4%)
Query: 80 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
+SCG EHS V +++ +G+ + GQLG+G IS P + L K+ +CG H
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAIS-KPTCVKALKPEKVKLAACGRNH 98
Query: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
+L ++ V++ G N+ GQLGLG + Q++AG S AL+
Sbjct: 99 TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
Query: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFT 259
G F WG NS GQ+ L +NV SN + V +ISCG H+A +T DG+++
Sbjct: 159 GRLFMWGDNSEGQIGL--KNV---SNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 260 FGDNRSGQLGY--SPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
FG+ +G+LG R PQLV I V Q+ CG HT+ V T V +FG G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV--VLTENAVYTFGLG 269
Score = 91.3 bits (225), Expect = 4e-18
Identities = 74/233 (31%), Positives = 112/233 (48%), Gaps = 14/233 (6%)
Query: 110 GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQ 169
G+ K P K ND+ + +SCG HS ++ +++++ +G N+ GQLGLG + +
Sbjct: 18 GKSKFAENNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK-SAI 75
Query: 170 ASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSG---RNVPVQSNK 226
+ P V++L+ + A G H+ + G + G N+ GQL L RN +
Sbjct: 76 SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISF 135
Query: 227 PLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERID 286
S +K L S G +A LT+DG++F +GDN GQ+G PQ V I
Sbjct: 136 FTSEHKIKQL-----SAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-TIG 189
Query: 287 GLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLIS 339
VS I CG YH+ A+V T G++ FG + K P L N L+S
Sbjct: 190 KPVSWISCGYYHS-AFVTTDGELYVFGE--PENGKLGLPNQLLGNHRTPQLVS 239
Score = 87.4 bits (215), Expect = 6e-17
Identities = 59/228 (25%), Positives = 112/228 (49%), Gaps = 6/228 (2%)
Query: 24 ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCG 83
++ Q ++G S L + R+ GDNS GQ+G + +P+ + + V +SCG
Sbjct: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCG 198
Query: 84 KEHSLAVCHKGRVFAWGAGSEGQLGI-GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
HS V G ++ +G G+LG+ + TP+ + + + K+IQV+CG H++
Sbjct: 199 YYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVV 257
Query: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202
L++++ V+++G GQLGLG + P+ + ++ ++ ++ G H+ ++ G
Sbjct: 258 LTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
Query: 203 FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
+ +G G+L L N L L+ + V ++CG H V
Sbjct: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI-VKLVACGGCHMVV 363
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 139 bits (349), Expect = 2e-32
Identities = 96/287 (33%), Positives = 151/287 (52%), Gaps = 9/287 (3%)
Query: 31 GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
G+ HS ++ N+++ G N+ GQLG P ++AL+ V L +CG+ H+L
Sbjct: 43 GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102
Query: 91 CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150
G V+A G +EGQLG+G+ +E + ++ KI Q+S G S AL++D ++F
Sbjct: 103 TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLF 162
Query: 151 SWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
WG NS GQ+GL K + PQ+V G P++ ++ G HS ++ G + +G
Sbjct: 163 MWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPEN 219
Query: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270
G+L L + + P V + V+ ++CG HT VLT++ V+TFG + GQLG
Sbjct: 220 GKLGLPNQLLG-NHRTPQLVSEIPE-KVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGL 276
Query: 271 SP-TPEKRGPQLVERI-DGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
E P+++E I D +S I CG HT A + G + +FG G
Sbjct: 277 GTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDG 322
Score = 119 bits (297), Expect = 2e-26
Identities = 83/238 (34%), Positives = 119/238 (50%), Gaps = 10/238 (4%)
Query: 80 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
+SCG EHS V +++ +G+ + GQLG+G IS P + L K+ +CG H
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAIS-KPTCVKALKPEKVKLAACGRNH 98
Query: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
+L ++ V++ G N+ GQLGLG + Q++AG S AL+
Sbjct: 99 TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
Query: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFT 259
G F WG NS GQ+ L +NV SN + V +ISCG H+A +T DG+++
Sbjct: 159 GRLFMWGDNSEGQIGL--KNV---SNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 260 FGDNRSGQLGY--SPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
FG+ +G+LG R PQLV I V Q+ CG HT+ V T V +FG G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV--VLTENAVYTFGLG 269
Score = 91.3 bits (225), Expect = 4e-18
Identities = 74/233 (31%), Positives = 112/233 (48%), Gaps = 14/233 (6%)
Query: 110 GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQ 169
G+ K P K ND+ + +SCG HS ++ +++++ +G N+ GQLGLG + +
Sbjct: 18 GKSKFAENNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK-SAI 75
Query: 170 ASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSG---RNVPVQSNK 226
+ P V++L+ + A G H+ + G + G N+ GQL L RN +
Sbjct: 76 SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISF 135
Query: 227 PLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERID 286
S +K L S G +A LT+DG++F +GDN GQ+G PQ V I
Sbjct: 136 FTSEHKIKQL-----SAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-TIG 189
Query: 287 GLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLIS 339
VS I CG YH+ A+V T G++ FG + K P L N L+S
Sbjct: 190 KPVSWISCGYYHS-AFVTTDGELYVFGE--PENGKLGLPNQLLGNHRTPQLVS 239
Score = 87.4 bits (215), Expect = 6e-17
Identities = 59/228 (25%), Positives = 112/228 (49%), Gaps = 6/228 (2%)
Query: 24 ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCG 83
++ Q ++G S L + R+ GDNS GQ+G + +P+ + + V +SCG
Sbjct: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCG 198
Query: 84 KEHSLAVCHKGRVFAWGAGSEGQLGI-GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
HS V G ++ +G G+LG+ + TP+ + + + K+IQV+CG H++
Sbjct: 199 YYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVV 257
Query: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202
L++++ V+++G GQLGLG + P+ + ++ ++ ++ G H+ ++ G
Sbjct: 258 LTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
Query: 203 FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
+ +G G+L L N L L+ + V ++CG H V
Sbjct: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI-VKLVACGGCHMVV 363
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 135 bits (339), Expect = 3e-31
Identities = 98/359 (27%), Positives = 167/359 (46%), Gaps = 22/359 (6%)
Query: 667 PPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFE 726
P + IL V R + + + +S+A + + V F E GV E+F +
Sbjct: 548 PVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEE-GMGQGVVREWFDILSN 606
Query: 727 EMTKPEYGMFMYPEMGSCMWFPAKP--KPEKKRYFLF-GMLCGLSLFNLNVANLPFPLAL 783
E+ P+Y +F G+ + P+ YF F G + GL+L + + N+ F +
Sbjct: 607 EIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSF 666
Query: 784 YKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWD----QNDVDLI 839
YK +L + +D+ + P K+LQ +LD+ D+G L + FS+ D +V L
Sbjct: 667 YKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLG--LELTFSVETDVFGAMEEVPLK 724
Query: 840 PNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTA 899
P G SI V Q NK +YV + +++ F +GF+ +++ F EL
Sbjct: 725 PGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELL 784
Query: 900 IIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDR---- 955
+ G + D + +N++Y GY++ P IQ FW+ +T +E+ L F+TG R
Sbjct: 785 LSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHG 844
Query: 956 -----LHARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAIN 1009
+ G+Q I ++ PTS TC N+L LP+Y + E +++ L VA++
Sbjct: 845 GFANIMGGSGLQNFTI---AAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH 900
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 129 bits (324), Expect = 1e-29
Identities = 104/311 (33%), Positives = 144/311 (46%), Gaps = 24/311 (7%)
Query: 11 ELQRRRTA---GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPE 67
ELQ R A GS G E+L N + G N G LG Q P
Sbjct: 41 ELQLIRQACVFGSAGNEVLYTT----------VNDEIFVLGTNCCGCLGLGDVQSTIEPR 90
Query: 68 PIQALETLIVDLVSCGK-EHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMT-L 125
+ +L + +S G H + +G VF WG + QLG G P I T L
Sbjct: 91 RLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNH-GLVPCHISTNL 149
Query: 126 NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLA 184
++ ++I+V+CG YHSL L+ D +VF+WG N+ GQ+G G +Q P+RV L+ +
Sbjct: 150 SNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTV-NQPIPRRVTGCLQNKVVV 208
Query: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLAL-SGRNVPVQSNKPLSVGALKNLGVVYISC 243
+A G A+ G + WG N GQL L + N P P V AL+ + V ++C
Sbjct: 209 TIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT----PCRVAALQGIRVQRVAC 264
Query: 244 GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVE-RIDGLVSQIDCGSYHTLAY 302
G AHT VLT +G+V+ +G N GQLG + P V D ++ C S HT A
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAA 324
Query: 303 VHTTGQVVSFG 313
G V +G
Sbjct: 325 KTQGGHVYMWG 335
Score = 69.3 bits (168), Expect = 2e-11
Identities = 45/149 (30%), Positives = 76/149 (51%), Gaps = 6/149 (4%)
Query: 9 SRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEP 68
++ + RR T ++ A G+ + ++ V G N GQLG + P
Sbjct: 191 NQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCR 250
Query: 69 IQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISF-TPKKIMTLND 127
+ AL+ + V V+CG H+L + +G+V+AWGA S GQLG G S+ TP +T+
Sbjct: 251 VAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTP---VTVEK 307
Query: 128 IKIIQVSCGH--YHSLALSKDSQVFSWGK 154
+II+++ H + S A ++ V+ WG+
Sbjct: 308 DRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 127 bits (318), Expect = 7e-29
Identities = 97/353 (27%), Positives = 166/353 (47%), Gaps = 14/353 (3%)
Query: 674 LRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEY 733
+ V R L +D+ +Q+ + D + L + E + GG++ E+F + E+ P Y
Sbjct: 78 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 137
Query: 734 GMFMYPEMGS-CMWF-PAKP-KPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLD 789
+F Y + C+ PA P+ YF F G ++L++ + F L YK++L+
Sbjct: 138 CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLN 197
Query: 790 QKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCI--RFSIHWDQNDVDLIPNGISIPV 847
++P+L+DL+ + P S+ + ++ ++ G L I +L G SI V
Sbjct: 198 KRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRV 257
Query: 848 DQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYD 907
+ NK +Y+ D+ F V+ + F GF V E LR+F +EL + G + D
Sbjct: 258 TEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEID 317
Query: 908 WKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIV 967
+++++ Y Y K+ IQ FW+ ++ +++ + L F+TG RL G ++ I
Sbjct: 318 MSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAEL-IG 375
Query: 968 FRCPETF------SERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
P+ F E P S TC N L LP Y + E++ E L AI GF
Sbjct: 376 SNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,441,268
Number of Sequences: 37866
Number of extensions: 1780203
Number of successful extensions: 5146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 4143
Number of HSP's gapped (non-prelim): 272
length of query: 1022
length of database: 18,247,518
effective HSP length: 112
effective length of query: 910
effective length of database: 14,006,526
effective search space: 12745938660
effective search space used: 12745938660
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.