Search of human proteins with 56237021

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|56237021 fibrillin 3 precursor [Homo sapiens]
         (2809 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|56237021 fibrillin 3 precursor [Homo sapiens]                     6291   0.0  
gi|66346695 fibrillin 2 precursor [Homo sapiens]                     4477   0.0  
gi|24430141 fibrillin 1 precursor [Homo sapiens]                     4007   0.0  
gi|110347437 latent transforming growth factor beta binding prot...   581   e-165
gi|110347412 latent transforming growth factor beta binding prot...   581   e-165
gi|110347431 latent transforming growth factor beta binding prot...   581   e-165
gi|46249414 latent transforming growth factor beta binding prote...   532   e-150
gi|46249412 latent transforming growth factor beta binding prote...   532   e-150
gi|4557733 latent transforming growth factor beta binding protei...   504   e-142
gi|148833508 notch1 preproprotein [Homo sapiens]                      494   e-139
gi|24041035 notch 2 preproprotein [Homo sapiens]                      473   e-133
gi|194328809 latent transforming growth factor beta binding prot...   468   e-131
gi|134244285 Notch homolog 3 [Homo sapiens]                           436   e-121
gi|18497288 latent transforming growth factor beta binding prote...   429   e-119
gi|55770876 notch4 preproprotein [Homo sapiens]                       344   6e-94
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               304   9e-82
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             290   1e-77
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             290   1e-77
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              288   7e-77
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              262   3e-69
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              251   5e-66
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              251   7e-66
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        251   7e-66
gi|118572606 hemicentin 1 [Homo sapiens]                              243   1e-63
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     235   4e-61
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              234   1e-60
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               231   1e-59
gi|4557679 jagged 1 precursor [Homo sapiens]                          217   1e-55
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               215   6e-55
gi|10190748 CEGP1 protein [Homo sapiens]                              209   3e-53

>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score = 6291 bits (16320), Expect = 0.0
 Identities = 2809/2809 (100%), Positives = 2809/2809 (100%)

Query: 1    MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 60
            MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
Sbjct: 1    MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC 60

Query: 61   GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 120
            GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
Sbjct: 61   GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 120

Query: 121  SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 180
            SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
Sbjct: 121  SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 180

Query: 181  DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 240
            DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
Sbjct: 181  DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 240

Query: 241  HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 300
            HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
Sbjct: 241  HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF 300

Query: 301  GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 360
            GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
Sbjct: 301  GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF 360

Query: 361  PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 420
            PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
Sbjct: 361  PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL 420

Query: 421  NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 480
            NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
Sbjct: 421  NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA 480

Query: 481  TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 540
            TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
Sbjct: 481  TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 540

Query: 541  CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 600
            CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
Sbjct: 541  CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG 600

Query: 601  GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 660
            GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
Sbjct: 601  GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA 660

Query: 661  KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 720
            KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
Sbjct: 661  KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK 720

Query: 721  DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 780
            DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
Sbjct: 721  DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC 780

Query: 781  RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840
            RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
Sbjct: 781  RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840

Query: 841  AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 900
            AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
Sbjct: 841  AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL 900

Query: 901  MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 960
            MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
Sbjct: 901  MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 960

Query: 961  EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 1020
            EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
Sbjct: 961  EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD 1020

Query: 1021 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 1080
            AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
Sbjct: 1021 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL 1080

Query: 1081 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1140
            LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
Sbjct: 1081 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC 1140

Query: 1141 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1200
            HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
Sbjct: 1141 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1200

Query: 1201 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1260
            EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
Sbjct: 1201 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS 1260

Query: 1261 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320
            FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
Sbjct: 1261 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH 1320

Query: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
            DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380

Query: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1440
            APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1440

Query: 1441 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1500
            GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
Sbjct: 1441 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1500

Query: 1501 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1560
            DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
Sbjct: 1501 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1560

Query: 1561 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1620
            LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
Sbjct: 1561 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1620

Query: 1621 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1680
            CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
Sbjct: 1621 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI 1680

Query: 1681 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1740
            GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
Sbjct: 1681 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1740

Query: 1741 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1800
            IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
Sbjct: 1741 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1800

Query: 1801 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1860
            GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
Sbjct: 1801 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1860

Query: 1861 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
            CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
Sbjct: 1861 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920

Query: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1980
            TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
Sbjct: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1980

Query: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 2040
            LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
Sbjct: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 2040

Query: 2041 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2100
            CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
Sbjct: 2041 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2100

Query: 2101 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2160
            VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
Sbjct: 2101 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2160

Query: 2161 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2220
            MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
Sbjct: 2161 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2220

Query: 2221 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2280
            RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
Sbjct: 2221 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2280

Query: 2281 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2340
            EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
Sbjct: 2281 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2340

Query: 2341 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2400
            LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
Sbjct: 2341 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2400

Query: 2401 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2460
            TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
Sbjct: 2401 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2460

Query: 2461 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2520
            CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
Sbjct: 2461 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2520

Query: 2521 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2580
            SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
Sbjct: 2521 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2580

Query: 2581 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2640
            SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
Sbjct: 2581 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2640

Query: 2641 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2700
            FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
Sbjct: 2641 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA 2700

Query: 2701 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2760
            TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
Sbjct: 2701 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS 2760

Query: 2761 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2809
            LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
Sbjct: 2761 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL 2809


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score = 4477 bits (11613), Expect = 0.0
 Identities = 1911/2852 (67%), Positives = 2277/2852 (79%), Gaps = 90/2852 (3%)

Query: 39   AAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQP 98
            AA   RVRRRG   +L+GPNVCGSRFH+YCCPGW+T PG +QC+VPICR +CG+GFCS+P
Sbjct: 68   AAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRP 127

Query: 99   NLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNG 158
            N+CTC+ G ++ +CG      CSV CMNGGTC    C CQKGY GT CGQP+C+ GC NG
Sbjct: 128  NMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNG 187

Query: 159  GRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAW 218
            GRCIGPNRCACVYGF GPQCERDYRTGPCF QV  + CQ QLTG+VCTK LCCAT+GRAW
Sbjct: 188  GRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAW 247

Query: 219  GLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGH 278
            G PCE+CPAQP PCRRGFIPNI TGACQDVDECQA+PG+CQGG+C+N VGSF CRCP GH
Sbjct: 248  GHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGH 307

Query: 279  RLSDSSAACEDY------------------------------------------RAGACF 296
            + S+++  CED                                           R G CF
Sbjct: 308  KQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCF 367

Query: 297  SVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPL--LP 354
            S L  GRCA +L G  T+ QCCC+ GRCW  G +PE CP RGS E+++LC   LP+  +P
Sbjct: 368  SGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIP 427

Query: 355  GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIP-----SLGPGNSNIGTA------ 403
            G  G  PG  G G NG  P        P G+    IP     S G G + +G        
Sbjct: 428  GSAGSRPG--GTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPII 485

Query: 404  ----TLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCH 459
                 LNQTIDIC+H  NLCLNGRC+PT SSYRCECN+GY QD  G+CIDVDECTS+PC 
Sbjct: 486  TGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCT 545

Query: 460  HGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAG 519
            +GDCVN PG+Y+C+C+ GFQ TPT+QAC+D+DECI +G LC  GRCVNT+GSFQC+CNAG
Sbjct: 546  NGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAG 605

Query: 520  FELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTP 579
            FEL+ DGKNCVDH+EC T+ MC+NG+C+NEDGSF C+CKPGF+LAP G YC D+DECQTP
Sbjct: 606  FELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTP 665

Query: 580  GICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTK 639
            GIC+NGHC N+EGSFRC C  GLAVG DGRVCVDTH+RSTCYG I+KG C RPFPG VTK
Sbjct: 666  GICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTK 725

Query: 640  SECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCE 699
            SECCCANPD+GFGEPCQ CPAK+SAEF  LCSSG+GIT DGRDINECALDP++CANG+CE
Sbjct: 726  SECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICE 785

Query: 700  NLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQ 759
            NLRGSYRC CN GYE  ASG++C D+DEC +N LLCDNG C+N+PGSYSC+CPPG+ F  
Sbjct: 786  NLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 845

Query: 760  DTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQES 819
            +TE C+D++EC S+PCV+G CRN  GS+ C+C PGS+L  +G  C+DS KGTCWL IQ+S
Sbjct: 846  ETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDS 905

Query: 820  RCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGV 879
            RCEVN+ GA+L+SECCATLGAAWGSPCERCE+D AC RG AR+ GVTC+DVNECE FPGV
Sbjct: 906  RCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGV 965

Query: 880  CPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVC 939
            CPNGRCVN+ GSF CECPEGL LD +GR+C+D+R+E C+L+WDEDEC   +PGK+RMD C
Sbjct: 966  CPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDAC 1025

Query: 940  CCSIGAVWGVECEACPDPESLEFASLCPRGLGFASR-DFLSGRPFYKDVNECKVFPGLCT 998
            CC++GA WG ECE CP P + E+ +LCPRG GFA+R D L+GRPFYKD+NECK FPG+CT
Sbjct: 1026 CCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCT 1085

Query: 999  HGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPG 1058
            +G CRNT+GSF C C  GFALD +ERNCTDIDECRISPDLCG G CVNTPGSFECECF G
Sbjct: 1086 YGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEG 1145

Query: 1059 YESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECS 1118
            YESGFM+MKNCMD+DEC R+PLLCRGGTC NT+GS++C CP GHEL+     C DI+ECS
Sbjct: 1146 YESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205

Query: 1119 LSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYR 1178
            LSD LC +G+CVN+IG +QCSC+ G+Q+TPDRQGC DI+EC + NGGCD  C N+EGSY 
Sbjct: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265

Query: 1179 CSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVD 1238
            CSC +GY+LMPDGR+CAD+DECE NP +CD G CTN+PG +RCLCYDGFMA+ DM+TC+D
Sbjct: 1266 CSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID 1325

Query: 1239 VDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCL 1298
            V+ECDLN +IC+ G+CENTKGSF+CHCQLGY V+KG TGC+DVDECE+G HNCD HASCL
Sbjct: 1326 VNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL 1385

Query: 1299 NIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF 1358
            NIPGSF C C  GW+G+G +C DLDEC +  H+CS    C+N PGSYRC C +GF GDGF
Sbjct: 1386 NIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGF 1445

Query: 1359 FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS 1418
             C D DECAEN++LC+NGQCLN PG YRCECEMGF P  D R+CQD+DEC+  N+C FG+
Sbjct: 1446 TCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGT 1505

Query: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELN 1478
            C NLPGMF CIC+ GYELDR GGNCTDI+ECADP+NC+NG+C+NTPG Y C+CP DF+LN
Sbjct: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLN 1565

Query: 1479 PSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMAN 1538
            P+GVGCVD R GNC+L+   RGD  +SC+ EIGVGV+R+SCCCSLG+AWGNPCE CP  N
Sbjct: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625

Query: 1539 TTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSE 1598
            +TEY TLCPGGEGF+PN IT+ILEDIDECQELPGLCQGG+C+NTFGSFQCECP GY+LSE
Sbjct: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685

Query: 1599 HTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYN 1658
             TRICEDIDEC  H G+CGPGTCYNTLGNYTC+CP EY+QVNGG+NCMDMRKS C+R YN
Sbjct: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745

Query: 1659 G-TCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTG 1717
            G TC+NEL FNVT++MCCC+YN+G+AWN+PCE CPTP + D++ +CGN  PGF  DIHTG
Sbjct: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGN-IPGFTFDIHTG 1804

Query: 1718 KPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQN 1777
            K +DIDEC EIP ICANG+CINQIGSFRCECP GF+YN +LL CED+DEC + ++ CQ+N
Sbjct: 1805 KAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRN 1864

Query: 1778 ADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQ 1837
            ADCIN PGSYRC+C  G+KLSP GACV RNEC EIPNVCSHG C+D +GSY C+CH GF+
Sbjct: 1865 ADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924

Query: 1838 ASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQV 1897
            AS DQT+CMD+DEC+R PCGNGTCKN +GSYNCLC+PGF +THN DC+D DEC++  GQV
Sbjct: 1925 ASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQV 1984

Query: 1898 CRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICP 1957
            CR G C N  GSF CLC +G+ELT DGKNC+DTNEC++L G+C PGTCQNLEGSFRCICP
Sbjct: 1985 CRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICP 2044

Query: 1958 PGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFC 2017
            PG++V+S++CIDI+EC E+PN+CLFG+CTN+PG FQCLCPPGFVLSDNG RCFDTRQSFC
Sbjct: 2045 PGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFC 2104

Query: 2018 FTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPG 2077
            FT FE GKCSVPKAFNTTK +CCCSK PGEGWGDPCELCP++   AFQ+LCP+GHG VP 
Sbjct: 2105 FTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPS 2164

Query: 2078 PDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCG 2137
              D+REDVNEC E+PG+C+NG C+NTDGSFRCECP GY+LD+TG+ CVDTDECS+G+PCG
Sbjct: 2165 LHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCG 2224

Query: 2138 QGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYT 2197
             GTCTNVIG FEC C +GFEPG MM CEDI+EC+ NPLLCAFRC NT GSY CTCP GY 
Sbjct: 2225 NGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYA 2284

Query: 2198 LREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECH 2257
            LRED  MC+D+DECA+G  DC +RGM CKNLIGTF C+CPPGM   P  GEGC D+NEC 
Sbjct: 2285 LREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRP-DGEGCVDENECR 2343

Query: 2258 AQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSE 2317
             +P +C NGRCVN  GS+RC+C+EGFQ S + TEC D RQG CFAEVLQT+C+  SSS  
Sbjct: 2344 TKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRN 2403

Query: 2318 AVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG 2377
             VT++ECCC GGRGWG +CELCPLPGT+ Y+K+CPHG GYT +GRD+DEC+++ +LC +G
Sbjct: 2404 LVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG 2463

Query: 2378 ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLL 2437
            +CIN++GSFRC C+ GYT D + T+C+D+DECSQ PKPC ++CKNT+GS+ CSCPRGY+L
Sbjct: 2464 QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVL 2523

Query: 2438 EEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCG 2497
            +EDG+TCKDLDEC ++QHNCQFLCVNT+G FTC+CPPGFTQHH AC DN+EC +QP  CG
Sbjct: 2524 QEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCG 2583

Query: 2498 AHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGF 2557
            A G C NTPGSF CEC +GF+L ++G  CEDV+ECDG HRCQHGCQN LGGYRC CPQG+
Sbjct: 2584 AKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGY 2643

Query: 2558 TQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGR 2617
             QH QW QCVDENEC+ +P  CGSASC NTLG ++C CPSGF FDQ    C +V+EC+  
Sbjct: 2644 IQHYQWNQCVDENECS-NPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSS 2702

Query: 2618 RGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ---DTP-DKEELLSSEAC 2673
            + PC+Y C+NT GG+LCGCP GY+R GQGHCVSG+GF+ G     DT  D+E  LS EAC
Sbjct: 2703 KNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEAC 2762

Query: 2674 YECKINGLSPRD-RPRRSAHRD-----HQVNLATLDSEALLTLGLNLSHLGRAERILELR 2727
            YECKING S +D R +RS H        Q++L ++D ++ + +  NLSHLG  E ILELR
Sbjct: 2763 YECKINGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILELR 2822

Query: 2728 PALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVVSHMAGPWGV 2787
            PA++ L   IRYVI +GN+   FR+H   G+S L   +++  PGTY LE+ S    P   
Sbjct: 2823 PAIQPLNNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSI---PLYK 2879

Query: 2788 QPEGQP-----------GPWGQALRLKVQLQL 2808
            + E +            G  G+ALR+++Q+QL
Sbjct: 2880 KKELKKLEESNEDDYLLGELGEALRMRLQIQL 2911


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score = 4007 bits (10393), Expect = 0.0
 Identities = 1709/2855 (59%), Positives = 2134/2855 (74%), Gaps = 105/2855 (3%)

Query: 8    LARGPLARLLLAWSALLCMAGGQGRWDGALEAAG-----PGRVRRRGSPG--ILQGPNVC 60
            + RG L  + L ++ LL      G  D  LEA         R +RRG  G   L+GPNVC
Sbjct: 1    MRRGRLLEIALGFTVLLASYTSHGA-DANLEAGNVKETRASRAKRRGGGGHDALKGPNVC 59

Query: 61   GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 120
            GSR++AYCCPGW+T PG +QC+VPICR +CG+GFCS+PN+CTC  G +APSCG      C
Sbjct: 60   GSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHC 119

Query: 121  SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 180
            ++ CMNGG+C    CLCQKGY GT CGQP+C+ GC NGGRC+ PNRCAC YGF GPQCER
Sbjct: 120  NIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCER 179

Query: 181  DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI 240
            DYRTGPCF  +  + CQ QL+G+VCTK LCCATVGRAWG PCE+CPAQPHPCRRGFIPNI
Sbjct: 180  DYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNI 239

Query: 241  HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDY---------- 290
             TGACQDVDECQA+PGLCQGG+C+N VGSF C+CP GH+L++ S  CED           
Sbjct: 240  RTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGIC 299

Query: 291  --------------------------------RAGACFSVLFGGRCAGDLAGHYTRRQCC 318
                                            R G C++ L  GRC+  L    T+ QCC
Sbjct: 300  EGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCC 359

Query: 319  CDRGRCWAAGPV--PELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLG 376
            CD GRCW+ G    PE+CP R + +F +LC+  + ++PG P   P           PPLG
Sbjct: 360  CDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPM-VIPGRPEYPP-----------PPLG 407

Query: 377  PAR----LNPHGSDARGIPS-------LGPGNSNIGTATLNQTIDICRHFTNLCLNGRCL 425
            P      + P       IP        L P         +N T D C+    LC NGRC+
Sbjct: 408  PIPPVLPVPPGFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVT-DYCQLVRYLCQNGRCI 466

Query: 426  PTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQ 485
            PTP S RCECN G+  D+RGECIDVDEC  +PC  G+C+N  G+Y C+C  G+Q+T TR 
Sbjct: 467  PTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQCRAGYQSTLTRT 526

Query: 486  ACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGV 545
             C D+DEC+ +G +C+ GRC+NT+GSF CVCNAGF ++ DGKNC D +EC+   MC+NG+
Sbjct: 527  ECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGM 586

Query: 546  CLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG 605
            C+NEDGSF C+CKPGF LA  G YC DI+EC+TPGIC+NG C NT+GS+RC+C  GLAVG
Sbjct: 587  CINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVG 646

Query: 606  TDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAE 665
             DGRVCVDTH+RSTCYG  ++G C +P  G VTKSECCCA+ ++ FGEPCQ CPA++SAE
Sbjct: 647  LDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAE 706

Query: 666  FQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDV 725
            +QALCSSG G+T+ G DINECALDP++C NG+CENLRG+Y+C+CN GYE  ++GK+C D+
Sbjct: 707  YQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDI 766

Query: 726  DECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAG 785
            +EC LNSLLCDNG C+N+PGS+ C+CP GF +  D + C+D+DEC SSPC++GVC+N  G
Sbjct: 767  NECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPG 826

Query: 786  SYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSP 845
            S+ C+C   S LDP+ T C+++ KGTCW  + + RCE+N+ GA+L+S+CC++LGAAWGSP
Sbjct: 827  SFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSP 886

Query: 846  CERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDAS 905
            C  C++DP C +G++R+ G  C+D++ECE FPGVC NG CVNT GSF+C+CP G+ LDA+
Sbjct: 887  CTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDAT 946

Query: 906  GRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVE-CEACPDPESLEFAS 964
            GR+C+D+RLE CFLR++++EC + + G++RMD CCCS+GA WG E CE CP   + E+  
Sbjct: 947  GRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEE 1006

Query: 965  LCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQER 1024
            LCPRG GFA+++  +G+PF+KD+NECK+ P LCTHG CRNT+GSF C C  GFALD++ER
Sbjct: 1007 LCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEER 1066

Query: 1025 NCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRG 1084
            NCTDIDECRISPDLCG+G CVNTPG FEC+C  GYESGFM+MKNCMD+DEC RDPLLCRG
Sbjct: 1067 NCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRG 1126

Query: 1085 GTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGF 1144
            G C NT+GSY+C+CPPGH+L+   +AC DI+EC LS  LCP+G+CVN+IG +QC+C+ G+
Sbjct: 1127 GVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGY 1186

Query: 1145 QSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204
             STPDR  CVDI+EC + NGGC+  C N+EGSY CSC  G++LMPD R+C D+DECE+NP
Sbjct: 1187 HSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNP 1246

Query: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCH 1264
             +CD G CTN+PG +RCLCYDGFMA+ DM+TCVDV+ECDLNP+ICL G CENTKGSF+CH
Sbjct: 1247 NICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICH 1306

Query: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDE 1324
            C +GY  +KG TGC+D++ECE+G HNC  HA C N  GSF C C PGW+GDG +C DLDE
Sbjct: 1307 CDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDE 1366

Query: 1325 CVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGG 1384
            C +  H CS   DC N  GSYRC C++G+ GDGF C D DEC+EN++LC NGQCLNAPGG
Sbjct: 1367 CSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGG 1426

Query: 1385 YRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCT 1444
            YRCEC+MGF P+ D +AC+D+DEC+  N+C FG+C NLPG+FRC C  GYELDR GGNCT
Sbjct: 1427 YRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCT 1486

Query: 1445 DINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSG- 1503
            D+NEC DP  CI+G C+NTPGSY+C CP DFELNP+ VGCVDTR+GNC+L+   RGD+G 
Sbjct: 1487 DVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGD 1546

Query: 1504 ISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILED 1563
             +CS EIGVGV++ASCCCSLG+AWG PCE+CP  NT+EY+ LCPGGEGF+PN ITVILED
Sbjct: 1547 TACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILED 1606

Query: 1564 IDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYN 1623
            IDECQELPGLCQGG C+NTFGSFQC CP GY+L+E TR+C+D++EC T  GICGPGTCYN
Sbjct: 1607 IDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECET-PGICGPGTCYN 1665

Query: 1624 TLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHY---NGTCQNELAFNVTRKMCCCSYNI 1680
            T+GNYTC+CP +Y+QVNGGNNCMDMR+S+C+R+Y   N TC  EL FN+T+KMCCCSYNI
Sbjct: 1666 TVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNI 1725

Query: 1681 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1740
            G+AWN+PCE CP P + ++  LCG+Q PGF+ DI+TG P+DIDEC EIP +C NG+CIN 
Sbjct: 1726 GRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINM 1785

Query: 1741 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1800
            +GSFRCECP GF YN  LL CED+DEC      CQ+NA+CIN  GSYRC C  GY+ +  
Sbjct: 1786 VGSFRCECPVGFFYNDKLLVCEDIDEC-QNGPVCQRNAECINTAGSYRCDCKPGYRFTST 1844

Query: 1801 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT 1860
            G C  RNEC+EIPN+CSHG C+DT GS+ CLCH GF+ + DQT+C+DI+EC+R  CGNGT
Sbjct: 1845 GQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGT 1904

Query: 1861 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
            C+N IGS+NC C  GF+++HN DC+D DEC +  G +CR G C+NT GSF C C +G+E+
Sbjct: 1905 CRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEV 1964

Query: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC 1980
              DG+ CVD NECL     C PGTCQNL+GS+RCICPPG+ +Q++ C DIDEC EEP +C
Sbjct: 1965 APDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEIC 2024

Query: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 2040
              GTC+N+ GSF+CLCP GF LS +G RC D R S+C+ +FE GKCS PK+ N +K  CC
Sbjct: 2025 ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC 2084

Query: 2041 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2100
            C+ + GEGWGDPCELCP E   AF+++CP+G G + GPDDS  D++EC E P VC +G C
Sbjct: 2085 CALK-GEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKE-PDVCKHGQC 2142

Query: 2101 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL 2160
            +NTDGS+RCECPFGY L   G  CVDTDECSVG+PCG GTC NVIGGFEC C +GFEPG 
Sbjct: 2143 INTDGSYRCECPFGYIL--AGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP 2200

Query: 2161 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA 2220
            MMTCEDI+EC+ NPLLCAFRC NT GSY C CP GY LRED  MC+D DEC +G+ DC  
Sbjct: 2201 MMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTE 2260

Query: 2221 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2280
            + MECKNLIGT+ C+C PG +  P  GEGC D+NEC  +P +C NGRC+NT GS+ C+C+
Sbjct: 2261 KQMECKNLIGTYMCICGPGYQRRP-DGEGCVDENECQTKPGICENGRCLNTRGSYTCECN 2319

Query: 2281 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2340
            +GF  SP   EC D R+G CF EVLQ MC+  SS+   VT++ECCC GGRGWGP CE+CP
Sbjct: 2320 DGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICP 2379

Query: 2341 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2400
              GT A++KLCPHG G+   G D+DEC+++  +C +GEC+N  GS+ C C+ GYTPD T 
Sbjct: 2380 FQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITG 2439

Query: 2401 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL 2460
            T+C+D++EC+Q PKPC F+CKNT+GS+ CSCP+GY+L+EDGR+CKDLDEC ++QHNCQFL
Sbjct: 2440 TSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFL 2499

Query: 2461 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV 2520
            CVNT+G FTC+CPPGFTQHH +C DN+EC++    CG+ G C NTPGSF CEC +GF+L 
Sbjct: 2500 CVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLD 2559

Query: 2521 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2580
             +G  CEDV+EC+G HRCQHGCQN +GGYRCSCPQG+ QH QW QCVDENEC LS   CG
Sbjct: 2560 QTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENEC-LSAHICG 2618

Query: 2581 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2640
             ASC NTLG ++C+CP+GF ++Q  GGCQ+++EC   + PCSY C+NT GG+LCGCP GY
Sbjct: 2619 GASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678

Query: 2641 FRAGQGHCVSGLGFSPGPQDTPDKEEL----LSSEACYECKINGLSPRDRPRRSAHR--- 2693
            FR GQGHCVSG+G   G  + P   E+    LS EACYECKING   R R RRS +    
Sbjct: 2679 FRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSPEACYECKINGYPKRGRKRRSTNETDA 2738

Query: 2694 ---------DHQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRG 2744
                     +  V+LA+ D E       N+SH+    RILEL PAL  L    RY+I  G
Sbjct: 2739 SNIEDQSETEANVSLASWDVEKTAIFAFNISHVSNKVRILELLPALTTLTNHNRYLIESG 2798

Query: 2745 NEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVVS 2779
            NE GFF+++   G+S L   +++P  GTY L++ S
Sbjct: 2799 NEDGFFKINQKEGISYLHFTKKKPVAGTYSLQISS 2833


>gi|110347437 latent transforming growth factor beta binding protein 4
            isoform c [Homo sapiens]
          Length = 1557

 Score =  581 bits (1497), Expect = e-165
 Identities = 439/1396 (31%), Positives = 570/1396 (40%), Gaps = 207/1396 (14%)

Query: 620  CYGAIEKGSCARPFPGTVTKSECCCANPDHGFG-EPCQLCPAK--DSAEFQAL---CSSG 673
            C+  +  G CA P PG  T+ E CC      +G   CQLC  +  +S    A    C +G
Sbjct: 222  CFRELRGGECASPLPGLRTQ-EVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 280

Query: 674  LG-ITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNS 732
               +     D++ECA     C +G C N RG Y CVC  G+   +S   C  + +  ++ 
Sbjct: 281  FERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE 337

Query: 733  LLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGS---YTC 789
                 G C        CS P   +  +    C  V +     C   +C           C
Sbjct: 338  A---KGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQ--LCPPFGSEGFREIC 392

Query: 790  KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVN----LQGASLRSECCATLGAAWGSP 845
              GPG     S     D    T  L  +  R  ++    L   S  S            P
Sbjct: 393  PAGPGYHYSAS-----DLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRP 447

Query: 846  CERCEIDPACARGFARMTGVTCDDVNE-------CESFPGVCPNGRCVNTAGSFRCECPE 898
              R +  P        +   T  ++ E       C+  P VC  GRC++    + C C  
Sbjct: 448  EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDS 507

Query: 899  GLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPE 958
            G  L   G  C+DV           DEC    P         C+ G      CE  P   
Sbjct: 508  GFRLSPQGTRCIDV-----------DECRRVPPP--------CAPG-----RCENSPG-- 541

Query: 959  SLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFA 1018
               F  +C  G     R          DV+EC   P  C  G C NT GSF C C  G+ 
Sbjct: 542  --SFRCVCGPGFRAGPR-----AAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQ 594

Query: 1019 LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARD 1078
                  +C D+DEC  SP LCG+G C N PGSF C C  G+           DVDECA++
Sbjct: 595  AAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE----DVDECAQE 650

Query: 1079 PLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQC 1138
            P  C  G C NT GS+ C CP G      G  C+D+DEC+ S   C +G+C N  G+FQC
Sbjct: 651  PPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQC 710

Query: 1139 SCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRC-SCGQGYSLMPDGRACADV 1197
             C  GFQ       C D++EC          C+N+ GS++C +C  G+ L   GR C DV
Sbjct: 711  VCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHR-GR-CTDV 768

Query: 1198 DECEENPRVCD-QGHCTNMPGGHRCLCYDGFMATPDMRT--CVDVDECDLNPHICL-HGD 1253
            DEC      C   GHCTN  G  RC C  G+ A P  R   C DV+EC L    C  HG+
Sbjct: 769  DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRA-PSGRPGPCADVNEC-LEGDFCFPHGE 826

Query: 1254 CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWV 1313
            C NT GSF C C  GY        C DVDEC      C S   C N  GSF C C PG  
Sbjct: 827  CLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDL-CQS-GICTNTDGSFECICPPGHR 884

Query: 1314 G--DGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCT--CRQGF-AGDGFFCEDRDECAE 1368
               D   C D+DEC  +         C N PGSYRC   C  G+ AG    C+D DEC E
Sbjct: 885  AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQE 944

Query: 1369 -NVDLCDNGQCLNAPGGYRCE--CEMGFDPTEDHRACQDVDECAQGNLC-AFGSCENLPG 1424
               ++C   +C N PG YRC   C+ G+ PT     CQDVDEC   + C A   C+NLPG
Sbjct: 945  YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPG 1003

Query: 1425 MFRCICNGGYELDRGGGNCTDINECADPVN-CINGVCINTPGSYLCSCPQD-FELNPSGV 1482
             F+C+C+ GYE  R G +C D+NEC      C   +C N  GS+LC CP    E +P   
Sbjct: 1004 SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG 1063

Query: 1483 GCVDTRAG-------------------------------------------NCFLETHDR 1499
             CV  R                                              C+ +T   
Sbjct: 1064 RCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTA-- 1121

Query: 1500 GDSGISCSAEIGVGVTRASCCCSLGRAWGNPCEL--CPMANTTEYRTLCPGGEGF-QPNR 1556
              +  +C   +   VT   CCC++G  WG+ C +  CP   T EY++LCP G G+  P+ 
Sbjct: 1122 --APDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSG 1179

Query: 1557 ITVILEDIDECQELPG-LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGI 1615
               +  D+DECQ     +C+ G CVNT   + C C  GY+       C D DEC+     
Sbjct: 1180 DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPA 1239

Query: 1616 CGPGTCYNTLGNYTCVCPAEYLQVNGGNNC-------MDMRKSVCFRHYNG--TCQN-EL 1665
            C  G C NT+G+Y C C    +       C       +D    VC++       C +  L
Sbjct: 1240 CEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRL 1299

Query: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAP---------GF------ 1710
                T   CCC Y  G+AW   C  CP   S D++ LC    P         GF      
Sbjct: 1300 DRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEY 1357

Query: 1711 ---LTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC 1767
               L   + G P    E    PA+  +          R E P G     +    +D    
Sbjct: 1358 GPDLGPPYQGLPYG-PELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPY 1416

Query: 1768 GSRESPCQQNADCINIPGS---YRCKCTRGYKLSP-----GGACVG----------RNEC 1809
            G  E+P          PG+   YR + TR     P     GG+  G            EC
Sbjct: 1417 GESEAPAPPG------PGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEEC 1470

Query: 1810 REIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP-----CGNGTCKNI 1864
              I + C++G C+     + C C  G++    +  C+DI+ECD        C N  C N 
Sbjct: 1471 -GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1529

Query: 1865 IGSYNCLCFPGFVVTH 1880
             GS+ C+C PGF  TH
Sbjct: 1530 DGSFRCICRPGFAPTH 1545



 Score =  538 bits (1386), Expect = e-152
 Identities = 356/1161 (30%), Positives = 481/1161 (41%), Gaps = 168/1161 (14%)

Query: 810  GTCWLKIQESRCEVNLQGASLRSECCATLGAAWG-SPCERCEI-----------DPACAR 857
            G C+ +++   C   L G   +  CC   G AWG   C+ C             D  C  
Sbjct: 220  GYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPT 279

Query: 858  GFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRL--- 914
            GF R+ G +C+DV+EC +  G C +G C NT G + C CP+G +LD+S   C+   +   
Sbjct: 280  GFERVNG-SCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISE 337

Query: 915  --EPCFLRWDEDECGVTLPGKYRMDVCCCS-IGAVWGVECEACPDPESLEFASLCPRGLG 971
               PCF    +  C + +       +CCCS +G  WG  C+ CP   S  F  +CP G G
Sbjct: 338  AKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPG 397

Query: 972  F---ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVG--------------------- 1007
            +   AS    + RP  ++     +        T R + G                     
Sbjct: 398  YHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGP 457

Query: 1008 SFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM- 1066
                     +       +      C+ +P +CG G C++ P  + C C    +SGF L  
Sbjct: 458  ELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCAC----DSGFRLSP 513

Query: 1067 --KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLC 1124
                C+DVDEC R P  C  G C N+ GS++C C PG     +   C D+DEC      C
Sbjct: 514  QGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC 573

Query: 1125 PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCD-VHCINTEGSYRCSCGQ 1183
              G+C N  G+F C C AG+Q+ P    C D++EC    G C    C N  GS+RC C  
Sbjct: 574  DLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPA 633

Query: 1184 GYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC 1242
            G+     G AC  DVDEC + P  C  G C N  G   C C  GF +      C DVDEC
Sbjct: 634  GFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC 689

Query: 1243 DLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPG 1302
              +P  C +G CENT+GSF C C +G+      + C DVDECE   H       C+N PG
Sbjct: 690  ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE--NHLACPGQECVNSPG 747

Query: 1303 SFSCR-CLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF---AGDGF 1358
            SF CR C  G       C D+DEC S    C P G C N  GS+RC+C  G+   +G   
Sbjct: 748  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 807

Query: 1359 FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS 1418
             C D +EC E      +G+CLN  G + C C  G+ P     +C DVDEC++ +LC  G 
Sbjct: 808  PCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGI 867

Query: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECAD--PVNCINGVCINTPGSYLC--SCPQD 1474
            C N  G F CIC  G+       +C D++EC +  P  C +  C N+PGSY C   C   
Sbjct: 868  CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPG 927

Query: 1475 FELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELC 1534
            +   P G              T D  D       EI          C   R     CE  
Sbjct: 928  YHAGPEG--------------TCDDVDECQEYGPEI----------CGAQR-----CENT 958

Query: 1535 PMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGY 1594
            P      YR       G+QP       +D+DEC+          C N  GSFQC C  GY
Sbjct: 959  P----GSYRCTPACDPGYQPTP-GGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGY 1013

Query: 1595 HLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVC---PAEYLQVNGGNNC------ 1645
              +   R C D++EC T  G+CG   C N  G++ CVC   P E+  + G   C      
Sbjct: 1014 EGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG--RCVPPRTS 1071

Query: 1646 -------------------------MDMRKSVCFRHYNGTCQNELAFNVTRKMCC----- 1675
                                     +  R S   +   G+ + E  F+      C     
Sbjct: 1072 AGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILA 1131

Query: 1676 -------CSYNIGQAWNRPC--EACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG 1726
                   C   +G+ W   C  + CP   + +YQ LC +               D+DEC 
Sbjct: 1132 RNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQ 1191

Query: 1727 EI-PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785
                 +C +G+C+N    + C C  G+ Y++  L C D DEC   E  C +   C+N  G
Sbjct: 1192 LFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCVNTVG 1250

Query: 1786 SYRCKCTRGYKLSPGGACVGRNECREIPN-------------VCSHGDCMDTEGSYM-CL 1831
            SY C C     L         NE + + +             VCSH   +D + +Y  C 
Sbjct: 1251 SYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH-PRLDRQATYTECC 1309

Query: 1832 CHRGFQASADQTLCMDIDECD 1852
            C  G     D  LC   D  D
Sbjct: 1310 CLYGEAWGMDCALCPAQDSDD 1330



 Score =  453 bits (1166), Expect = e-127
 Identities = 344/1156 (29%), Positives = 457/1156 (39%), Gaps = 260/1156 (22%)

Query: 1430 CNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
            C  G+E  R  G+C D++ECA    C +G C NT G Y C CP  F L+ S   C+    
Sbjct: 277  CPTGFE--RVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 334

Query: 1490 -----GNCFLETHDRGDSGISCSAEIGVGVTRASCCCS-LGRAWGNPC------------ 1531
                 G CF    D G     CS  I   +T+  CCCS +G+AWG  C            
Sbjct: 335  ISEAKGPCFRVLRDGG-----CSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFR 389

Query: 1532 ELCPM-------ANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFG 1584
            E+CP        A+   Y T   G E   P R++     + + + LP   +         
Sbjct: 390  EICPAGPGYHYSASDLRYNTRPLGQE---PPRVS-----LSQPRTLPATSRPSAGFLPTH 441

Query: 1585 SFQC------------ECP----PGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNY 1628
              +             E P    P +   E          C  +  +CGPG C +    Y
Sbjct: 442  RLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGY 501

Query: 1629 TCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPC 1688
            TC C + +     G  C+D+ +                                     C
Sbjct: 502  TCACDSGFRLSPQGTRCIDVDE-------------------------------------C 524

Query: 1689 EACPTPISP--------DYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1740
               P P +P         ++ +CG   PGF       + LD+DEC  +P  C  G C N 
Sbjct: 525  RRVPPPCAPGRCENSPGSFRCVCG---PGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 581

Query: 1741 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLS-- 1798
             GSF C CPAG+       +C+DVDEC      C + A C N+PGS+RC C  G++ S  
Sbjct: 582  PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSAC 640

Query: 1799 --------------------------------------PGGACVGRNECREIPNVCSHGD 1820
                                                  PG  C   +EC   P  C++G 
Sbjct: 641  EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 700

Query: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ-PCGNGTCKNIIGSYNCLCFPGFVVT 1879
            C +TEGS+ C+C  GFQ +   + C D+DEC+    C    C N  GS+ C   P     
Sbjct: 701  CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL 760

Query: 1880 HNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN-CVDTNECLSLAG 1938
            H G C D DEC++        GHC NT GSF C C  G+   +     C D NECL    
Sbjct: 761  HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLE-GD 819

Query: 1939 TCLP-GTCQNLEGSFRCICPPGFQ--VQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCL 1995
             C P G C N +GSF C C PG++   +   C+D+DECSEE +LC  G CTN+ GSF+C+
Sbjct: 820  FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE-DLCQSGICTNTDGSFECI 878

Query: 1996 CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCEL 2055
            CPPG     +   C D  +                         C  + P       CE 
Sbjct: 879  CPPGHRAGPDLASCLDVDE-------------------------CRERGPALCGSQRCEN 913

Query: 2056 CPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAE-NPGVCTNGVCVNTDGSFRC--ECP 2112
             P  GS      C  G+ A  GP+ + +DV+EC E  P +C    C NT GS+RC   C 
Sbjct: 914  SP--GSYRCVRDCDPGYHA--GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACD 969

Query: 2113 FGYSLDFTGINCVDTDECSVGHPCG-QGTCTNVIGGFECACADGFEPGL-MMTCEDIDEC 2170
             GY     G  C D DEC     CG    C N+ G F+C C  G+E       C D++EC
Sbjct: 970  PGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNEC 1028

Query: 2171 SLNPLLC-AFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
                 +C A  C N EGS+LC CP                   +       R +  +   
Sbjct: 1029 ETLQGVCGAALCENVEGSFLCVCP----------------NSPEEFDPMTGRCVPPRTSA 1072

Query: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
            GTF     PG +P            +  A P L                      P P  
Sbjct: 1073 GTF-----PGSQP------------QAPASPVLPARP-----------------PPPPLP 1098

Query: 2290 TECHDIRQGPC--------FAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL--C 2339
                  RQGP         F       C ++ + +  VT  ECCC  G GWG  C +  C
Sbjct: 1099 RRPSTPRQGPVGSGRRECYFDTAAPDACDNILARN--VTWQECCCTVGEGWGSGCRIQQC 1156

Query: 2340 PLPGTSAYRKLCPHGSGYTAEG------RDVDECRMLA-HLCAHGECINSLGSFRCHCQA 2392
            P   T+ Y+ LCPHG GY A        RDVDEC++    +C  G C+N+   + C+C  
Sbjct: 1157 PGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1216

Query: 2393 GYTPDATATTCLDMDECSQVPKPCT-FLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT 2451
            GY        C+D DEC+     C    C NT GS+ C+C    +L+   R C   +E  
Sbjct: 1217 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQ 1275

Query: 2452 SRQHNCQFLCVNTVGA 2467
            S   N   +C   VGA
Sbjct: 1276 SLDDNLG-VCWQEVGA 1290



 Score =  452 bits (1163), Expect = e-126
 Identities = 378/1156 (32%), Positives = 480/1156 (41%), Gaps = 220/1156 (19%)

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGL-PCELCP----------AQPHPCR 233
            G CF ++    C   L GL  T+ +CC   G AWG+  C+LC           A   PC 
Sbjct: 220  GYCFRELRGGECASPLPGLR-TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 278

Query: 234  RGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA- 292
             GF      G+C+DVDEC A  G CQ G C N  G + C CP G  L  S ++C      
Sbjct: 279  TGF--ERVNGSCEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 335

Query: 293  ----GACFSVLFGGRCAGDLAGHYTRRQCCCDR-GRCWAAGPVPELCPPRGSNEFQQLCA 347
                G CF VL  G C+  +  + T++ CCC R G+ W  G   +LCPP GS  F+++C 
Sbjct: 336  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRG--CQLCPPFGSEGFREIC- 392

Query: 348  QRLPLLPGH-------------------------PGLFPGL----LGFGSNGMGPPLGPA 378
               P  PG+                         P   P       GF       P    
Sbjct: 393  ---PAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEP 449

Query: 379  RLNPHGSDARGIPSL----GPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCE 434
            R +P       +PS+    GP     G ++      +C+    +C  GRC+  PS Y C 
Sbjct: 450  RPDPRPGPELPLPSIPAWTGPEIPESGPSS-----GMCQRNPQVCGPGRCISRPSGYTCA 504

Query: 435  CNVGYTQDVRG-ECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVD 491
            C+ G+    +G  CIDVDEC     PC  G C N PG++ C C PGF+A P    C+DVD
Sbjct: 505  CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVD 564

Query: 492  ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATST-MCVNGVCLNED 550
            EC      C LGRC NT GSF CVC AG++ +P G +C D +EC  S  +C  G C N  
Sbjct: 565  ECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLP 624

Query: 551  GSFSCLCKPGFLLAPGGHYC-MDIDEC-QTPGICVNGHCTNTEGSFRCQCLGGLAVGTDG 608
            GSF C+C  GF     G  C  D+DEC Q P  C  G C NT GSF C C  G      G
Sbjct: 625  GSFRCVCPAGF----RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPG 680

Query: 609  RVC--VDTHVRS---TCYGAIE--KGS----CARPFPGTVTKSEC----CCANPDHGFGE 653
              C  VD   RS     YG  E  +GS    C   F      SEC     C N     G+
Sbjct: 681  APCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQ 740

Query: 654  PCQLCPAKDSAEFQA-LCSSGLGITTDGR--DINECALDPEVCA-NGVCENLRGSYRCVC 709
             C   P      FQ   C SG  +   GR  D++EC+     C  +G C N  GS+RC C
Sbjct: 741  ECVNSP----GSFQCRTCPSGHHLHR-GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 795

Query: 710  NLGYEAGASGK--DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV 767
              GY A  SG+   C DV+EC        +G C N+ GS++C+C PG+        C DV
Sbjct: 796  APGYRA-PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDV 854

Query: 768  DECLSSP-CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQ 826
            DEC     C SG+C N  GS+ C C PG R  P    CLD                    
Sbjct: 855  DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDV------------------- 895

Query: 827  GASLRSECCATLGAAWGSPCERCEIDPA-------CARGFARMTGVTCDDVNECESF-PG 878
                  EC     A  GS  +RCE  P        C  G+      TCDDV+EC+ + P 
Sbjct: 896  -----DECRERGPALCGS--QRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPE 948

Query: 879  VCPNGRCVNTAGSFRC--ECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRM 936
            +C   RC NT GS+RC   C  G      G  C DV           DEC          
Sbjct: 949  ICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDV-----------DEC---------R 987

Query: 937  DVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGL 996
            +   C   AV    C+  P      F  LC +G    +RD   GR    DVNEC+   G+
Sbjct: 988  NRSFCGAHAV----CQNLPG----SFQCLCDQGYE-GARD---GR-HCVDVNECETLQGV 1034

Query: 997  CTHGTCRNTVGSFHCAC--------------------AGGFALDAQERNCTDIDECRISP 1036
            C    C N  GSF C C                    AG F     +   + +   R  P
Sbjct: 1035 CGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1094

Query: 1037 DLCGQGTCVNTP-----GSFECECFPGYES----GFMLMKN------CMDVDECARDPLL 1081
                +    +TP     GS   EC+    +      +L +N      C  V E       
Sbjct: 1095 PPLPRRP--STPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSG-- 1150

Query: 1082 CRGGTCTNTD-GSYKCQCPPGHELTAKG---TACEDIDECSL-SDGLCPHGQCVNVIGAF 1136
            CR   C  T+   Y+  CP G    A     +   D+DEC L  D +C  G CVN    +
Sbjct: 1151 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1210

Query: 1137 QCSCHAGFQSTPDRQGCVDINECRVQNGGCD-VHCINTEGSYRCSCGQGYSLMPDGRACA 1195
             C C  G+     R  C+D +EC  +   C+   C+NT GSY C+C     L    R C 
Sbjct: 1211 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1270

Query: 1196 --DVDECEENPRVCDQ 1209
              +    ++N  VC Q
Sbjct: 1271 SNESQSLDDNLGVCWQ 1286



 Score =  442 bits (1137), Expect = e-123
 Identities = 292/923 (31%), Positives = 399/923 (43%), Gaps = 164/923 (17%)

Query: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQ-GNLCAFGSCENLPG 1424
            C  N  +C  G+C++ P GY C C+ GF  +     C DVDEC +    CA G CEN PG
Sbjct: 482  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 541

Query: 1425 MFRCICNGGYELDRGGGNCTDINECAD-PVNCINGVCINTPGSYLCSCPQDFELNPSGVG 1483
             FRC+C  G+        C D++EC   P  C  G C NTPGS+LC CP  ++  P G  
Sbjct: 542  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGAS 601

Query: 1484 CVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYR 1543
            C D                                C  S G      C+  P +    +R
Sbjct: 602  CQDVD-----------------------------ECTQSPGLCGRGACKNLPGS----FR 628

Query: 1544 TLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC 1603
             +CP G      R +   ED+DEC + P  C  G C NT GSF C CP G+        C
Sbjct: 629  CVCPAGF-----RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC 683

Query: 1604 EDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQN 1663
            +D+DEC+     C  G C NT G++ CVCP  +     G+ C D+ +          C+N
Sbjct: 684  QDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE----------CEN 733

Query: 1664 ELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDID 1723
             LA       C     +    +  C  CP+          G+        +H G+  D+D
Sbjct: 734  HLA-------CPGQECVNSPGSFQCRTCPS----------GHH-------LHRGRCTDVD 769

Query: 1724 ECGEIPAICA-NGICINQIGSFRCECPAGFNYNSILLA-CEDVDECGSRESPCQQNADCI 1781
            EC      C  +G C N  GSFRC C  G+   S     C DV+EC   +  C  + +C+
Sbjct: 770  ECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECL 828

Query: 1782 NIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASA 1840
            N  GS+ C C  GY+  P GA C+  +EC E  ++C  G C +T+GS+ C+C  G +A  
Sbjct: 829  NTDGSFACTCAPGYRPGPRGASCLDVDECSE-EDLCQSGICTNTDGSFECICPPGHRAGP 887

Query: 1841 DQTLCMDIDEC-DRQP--CGNGTCKNIIGSYNCL--CFPGFVVTHNGDCVDFDECTTLVG 1895
            D   C+D+DEC +R P  CG+  C+N  GSY C+  C PG+     G C D DEC     
Sbjct: 888  DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 947

Query: 1896 QVCRFGHCLNTAGSFHCL--CQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFR 1953
            ++C    C NT GS+ C   C  G++ T  G  C D +EC + +       CQNL GSF+
Sbjct: 948  EICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQ 1006

Query: 1954 CICPPGFQVQSD--HCIDIDECSEEPNLC-----------LFGTCTNSPGSF-----QCL 1995
            C+C  G++   D  HC+D++EC     +C               C NSP  F     +C+
Sbjct: 1007 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1066

Query: 1996 CPPGFVLSDNGHR-----------------------------CFDTRQSFCFTRFEAGKC 2026
             P     +  G +                                 R+   F       C
Sbjct: 1067 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1126

Query: 2027 SVPKAFNTTKTRCCCSKRPGEGWGDPCEL--CPQEGSAAFQELCPFGHG--AVPGPDDSR 2082
                A N T   CCC+   GEGWG  C +  CP   +A +Q LCP G G  A  G    R
Sbjct: 1127 DNILARNVTWQECCCTV--GEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLR 1184

Query: 2083 EDVNECAE-NPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP-CGQGT 2140
             DV+EC      VC +GVCVNT   + C C  GY      + C+D DEC+   P C  G 
Sbjct: 1185 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1244

Query: 2141 CTNVIGGFECACADGFEPGLMM-----TCEDIDECSLN------------PLLCAFRCHN 2183
            C N +G + C C    EP L++      C   +  SL+             L+C+    +
Sbjct: 1245 CVNTVGSYHCTC----EPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLD 1300

Query: 2184 TEGSYL-CTCPAGYTLREDGAMC 2205
             + +Y  C C  G     D A+C
Sbjct: 1301 RQATYTECCCLYGEAWGMDCALC 1323



 Score =  440 bits (1131), Expect = e-122
 Identities = 363/1186 (30%), Positives = 488/1186 (41%), Gaps = 203/1186 (17%)

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG-NPCELCPMANTTEYRTLCPG 1548
            G CF E       G  C++ +    T+  CC   G AWG + C+LC        R   P 
Sbjct: 220  GYCFRELR-----GGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPD 274

Query: 1549 GEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDE 1608
            G                                        CP G+     +  CED+DE
Sbjct: 275  GP---------------------------------------CPTGFERVNGS--CEDVDE 293

Query: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMR-----KSVCFRHY-NGTCQ 1662
            C+T  G C  G C NT G YTCVCP  +L  +  ++C+        K  CFR   +G C 
Sbjct: 294  CAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCS 352

Query: 1663 NELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGF---LTDI-HTGK 1718
              +  N+T+++CCCS  +G+AW R C+ CP   S  ++ +C    PG+    +D+ +  +
Sbjct: 353  LPILRNITKQICCCS-RVGKAWGRGCQLCPPFGSEGFREICP-AGPGYHYSASDLRYNTR 410

Query: 1719 PLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNA 1778
            PL     G+ P      + ++Q  +     PA    ++  L    + E      P  +  
Sbjct: 411  PL-----GQEPP----RVSLSQPRTL----PATSRPSAGFLPTHRL-EPRPEPRPDPRPG 456

Query: 1779 DCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA 1838
              + +P         G ++   G   G   C+  P VC  G C+     Y C C  GF+ 
Sbjct: 457  PELPLPS---IPAWTGPEIPESGPSSGM--CQRNPQVCGPGRCISRPSGYTCACDSGFRL 511

Query: 1839 SADQTLCMDIDECDR--QPCGNGTCKNIIGSYNCLCFPGFVV-THNGDCVDFDECTTLVG 1895
            S   T C+D+DEC R   PC  G C+N  GS+ C+C PGF       +C+D DEC   V 
Sbjct: 512  SPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHR-VP 570

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI 1955
              C  G C NT GSF C+C  G++    G +C D +EC    G C  G C+NL GSFRC+
Sbjct: 571  PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 630

Query: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
            CP GF+  +    D+DEC++EP  C  G C N+ GSF C CP GF     G  C D  + 
Sbjct: 631  CPAGFRGSACE-EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE- 688

Query: 2016 FCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV 2075
                                     C++ P       CE    EGS  FQ +CP G    
Sbjct: 689  -------------------------CARSPPPCTYGRCE--NTEGS--FQCVCPMGFQPN 719

Query: 2076 PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCE-CPFGYSLDFTGINCVDTDECSVGH 2134
                +  EDV+EC EN   C    CVN+ GSF+C  CP G+ L      C D DECS G 
Sbjct: 720  TAGSEC-EDVDEC-ENHLACPGQECVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGA 775

Query: 2135 P-CG-QGTCTNVIGGFECACADGFEP--GLMMTCEDIDECSLNPLLCAF-RCHNTEGSYL 2189
            P CG  G CTN  G F C+CA G+    G    C D++EC           C NT+GS+ 
Sbjct: 776  PPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFA 835

Query: 2190 CTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249
            CTC  GY     GA C DVDEC++  +D    G+ C N  G+F C+CPPG R  P     
Sbjct: 836  CTCAPGYRPGPRGASCLDVDECSE--EDLCQSGI-CTNTDGSFECICPPGHRAGPDLAS- 891

Query: 2250 CTDDNECHAQ-PDLCVNGRCVNTAGSFRC--DCDEGFQPSPTLT-----ECHDIRQGPCF 2301
            C D +EC  + P LC + RC N+ GS+RC  DCD G+   P  T     EC +     C 
Sbjct: 892  CLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICG 951

Query: 2302 AEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCE---------LCP-LPGTSAYRKLC 2351
            A+  +    S   +       +   GGG      C          +C  LPG+  ++ LC
Sbjct: 952  AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGS--FQCLC 1009

Query: 2352 PHGSGYTAEGR---DVDECRML-----AHLCAHGE------CINSLGSF-----RC---H 2389
              G     +GR   DV+EC  L     A LC + E      C NS   F     RC    
Sbjct: 1010 DQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPR 1069

Query: 2390 CQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDE 2449
              AG  P +           ++ P P                PR       G       E
Sbjct: 1070 TSAGTFPGSQPQAPASPVLPARPPPP--------------PLPRRPSTPRQGPVGSGRRE 1115

Query: 2450 C---TSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTP 2506
            C   T+    C  +    V    C C  G             C  Q  P        +  
Sbjct: 1116 CYFDTAAPDACDNILARNVTWQECCCTVGEGW-------GSGCRIQQCPGTETAEYQSL- 1167

Query: 2507 GSFRCECHQGFTLVSSGHGCE-DVNECD--GPHRCQHG-CQNQLGGYRCSCPQGFTQHSQ 2562
                C   +G+   S       DV+EC       C+ G C N   GY C C  G+  H+Q
Sbjct: 1168 ----CPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1223

Query: 2563 WAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
              +C+D +ECA   P C    C NT+G + C C      D +   C
Sbjct: 1224 RLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1269



 Score =  407 bits (1046), Expect = e-113
 Identities = 296/890 (33%), Positives = 387/890 (43%), Gaps = 112/890 (12%)

Query: 1763 DVDECGSRESPCQQNAD------CINIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNV 1815
            ++ E G     CQ+N        CI+ P  Y C C  G++LSP G  C+  +ECR +P  
Sbjct: 471  EIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPP 530

Query: 1816 CSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDR--QPCGNGTCKNIIGSYNCLCF 1873
            C+ G C ++ GS+ C+C  GF+A      C+D+DEC R   PC  G C+N  GS+ C+C 
Sbjct: 531  CAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCP 590

Query: 1874 PGF-VVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV-DTN 1931
             G+    H   C D DECT   G +C  G C N  GSF C+C  GF     G  C  D +
Sbjct: 591  AGYQAAPHGASCQDVDECTQSPG-LCGRGACKNLPGSFRCVCPAGFR----GSACEEDVD 645

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSP 1989
            EC      C PG C N  GSF C CP GF+ +     C D+DEC+  P  C +G C N+ 
Sbjct: 646  ECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTE 705

Query: 1990 GSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKC----------SVPKAFNTTKTRC 2039
            GSFQC+CP GF  +  G  C D  +          +C          + P   +  + RC
Sbjct: 706  GSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC 765

Query: 2040 -----CCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGV 2094
                 C S  P  G    C     EGS  F+  C  G+ A  G      DVNEC E    
Sbjct: 766  TDVDECSSGAPPCGPHGHCT--NTEGS--FRCSCAPGYRAPSGRPGPCADVNECLEGDFC 821

Query: 2095 CTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACAD 2154
              +G C+NTDGSF C C  GY     G +C+D DECS    C  G CTN  G FEC C  
Sbjct: 822  FPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPP 881

Query: 2155 GFEPGL-MMTCEDIDEC-SLNPLLCAF-RCHNTEGSYLCT--CPAGYTLREDGAMCRDVD 2209
            G   G  + +C D+DEC    P LC   RC N+ GSY C   C  GY    +G  C DVD
Sbjct: 882  GHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT-CDDVD 940

Query: 2210 ECAD-GQQDCHARGMECKNLIGTFACV--CPPGMRPLPGSGEGCTDDNECHAQPDLCVNG 2266
            EC + G + C A+   C+N  G++ C   C PG +P PG G  C D +EC  +     + 
Sbjct: 941  ECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGGG--CQDVDECRNRSFCGAHA 996

Query: 2267 RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCC 2326
             C N  GSF+C CD+G++ +     C D+ +     E LQ +C +    +   +    C 
Sbjct: 997  VCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCVCP 1052

Query: 2327 GGGRGWGPRCELCPLPGTSAY-------------------------RKLCPHGSGYTAEG 2361
                 + P    C  P TSA                          R+      G    G
Sbjct: 1053 NSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSG 1112

Query: 2362 RDVDECRMLAHLCAHGECINSLGSF----RCHCQAGYTPDATATTCLDMDECSQVPKPCT 2417
            R   EC       A   C N L        C C  G   +   + C  + +C     P T
Sbjct: 1113 RR--ECYF--DTAAPDACDNILARNVTWQECCCTVG---EGWGSGCR-IQQC-----PGT 1159

Query: 2418 FLCKNTKGSFLCSCPRGYLLEE-DGRTCKDLDECTS-RQHNCQF-LCVNTVGAFTCRCPP 2474
               +  +   LC   RGYL    D    +D+DEC   R   C+  +CVNT   ++C C  
Sbjct: 1160 ---ETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1216

Query: 2475 GFTQHHQ--ACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC 2532
            G+  H Q   C DNDEC+ +   C   G C NT GS+ C C     L  S   C   NE 
Sbjct: 1217 GYYYHTQRLECIDNDECADEEPACEG-GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NES 1274

Query: 2533 DGPHRCQHGCQNQLGG-YRCSCPQGFTQHSQWAQCVDENE-----CALSP 2576
                     C  ++G    CS P+   Q +    C    E     CAL P
Sbjct: 1275 QSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCP 1324



 Score =  382 bits (981), Expect = e-105
 Identities = 275/840 (32%), Positives = 359/840 (42%), Gaps = 140/840 (16%)

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI 1955
            QVC  G C++    + C C  GF L+  G  C+D +EC  +   C PG C+N  GSFRC+
Sbjct: 487  QVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCV 546

Query: 1956 CPPGFQV--QSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013
            C PGF+   ++  C+D+DEC   P  C  G C N+PGSF C+CP G+  + +G  C D  
Sbjct: 547  CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVD 606

Query: 2014 QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG 2073
            +                          C++ PG      C+  P     +F+ +CP G  
Sbjct: 607  E--------------------------CTQSPGLCGRGACKNLP----GSFRCVCPAGFR 636

Query: 2074 AVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVG 2133
                     EDV+ECA+ P  C  G C NT GSF C CP G+     G  C D DEC+  
Sbjct: 637  G----SACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARS 692

Query: 2134 HP-CGQGTCTNVIGGFECACADGFEPGLMMT-CEDIDECSLNPLLCAFR-CHNTEGSYLC 2190
             P C  G C N  G F+C C  GF+P    + CED+DEC  N L C  + C N+ GS+ C
Sbjct: 693  PPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQC 751

Query: 2191 -TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249
             TCP+G+ L      C DVDEC+ G   C   G  C N  G+F C C PG R   G    
Sbjct: 752  RTCPSGHHLHR--GRCTDVDECSSGAPPCGPHG-HCTNTEGSFRCSCAPGYRAPSGRPGP 808

Query: 2250 CTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVL--Q 2306
            C D NEC  + D C  +G C+NT GSF C C  G++P P    C D+ +  C  E L   
Sbjct: 809  CADVNEC-LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE--CSEEDLCQS 865

Query: 2307 TMCRSLSSSSEAVTRAECCCGGGRGWGP----------------------RCELCPLPGT 2344
             +C +   S E      C C  G   GP                      RCE  P    
Sbjct: 866  GICTNTDGSFE------CICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSP---- 915

Query: 2345 SAYRKLCPHGSGYTA--EGR--DVDECRMLA-HLCAHGECINSLGSFRCH--CQAGYTPD 2397
             +YR +     GY A  EG   DVDEC+     +C    C N+ GS+RC   C  GY P 
Sbjct: 916  GSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQP- 974

Query: 2398 ATATTCLDMDEC-SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN 2456
                 C D+DEC ++       +C+N  GSF C C +GY    DGR C D++EC + Q  
Sbjct: 975  TPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGV 1034

Query: 2457 C-QFLCVNTVGAFTC--------------RCPPGFTQHHQACFDNDECSAQP-----GPC 2496
            C   LC N  G+F C              RC P  T          +  A P      P 
Sbjct: 1035 CGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1094

Query: 2497 GAHGHCHNTP-----GSFRCECHQGFTLVSSGHGCEDV-------NEC--------DGPH 2536
                   +TP     GS R EC+      ++   C+++        EC            
Sbjct: 1095 PPLPRRPSTPRQGPVGSGRRECYFD---TAAPDACDNILARNVTWQECCCTVGEGWGSGC 1151

Query: 2537 RCQHGCQNQLGGYRCSCPQG---FTQHSQWAQCVDENECAL-SPPTCGSASCRNTLGGFR 2592
            R Q     +   Y+  CP G          +   D +EC L     C S  C NT  G+ 
Sbjct: 1152 RIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYS 1211

Query: 2593 CVCPSGFDFDQALGGCQEVDECAGRRGPCSYS-CANTPGGFLCGC-PQGYFRAGQGHCVS 2650
            C C +G+ +      C + DECA     C    C NT G + C C P       Q  CVS
Sbjct: 1212 CYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS 1271



 Score =  374 bits (960), Expect = e-103
 Identities = 268/807 (33%), Positives = 329/807 (40%), Gaps = 156/807 (19%)

Query: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGF-------------VL 2002
            CP GF+  +  C D+DEC+     C  G C N+ G + C+CP GF             V+
Sbjct: 277  CPTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 335

Query: 2003 SDNGHRCFD---------------TRQSFCFTRFEAGK-----CSVPKAFNTTKTRCCCS 2042
            S+    CF                T+Q  C +R   GK     C +   F +   R  C 
Sbjct: 336  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSR--VGKAWGRGCQLCPPFGSEGFREICP 393

Query: 2043 KRPGEGWGD-------------------------PCELCPQEGSAAFQELCPFGHGAV-- 2075
              PG  +                           P    P  G      L P        
Sbjct: 394  AGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDP 453

Query: 2076 -PGPD---------------DSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDF 2119
             PGP+               +S      C  NP VC  G C++    + C C  G+ L  
Sbjct: 454  RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSP 513

Query: 2120 TGINCVDTDECS-VGHPCGQGTCTNVIGGFECACADGFEPGLMMT-CEDIDECSLNPLLC 2177
             G  C+D DEC  V  PC  G C N  G F C C  GF  G     C D+DEC   P  C
Sbjct: 514  QGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC 573

Query: 2178 AF-RCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVC 2236
               RC NT GS+LC CPAGY     GA C+DVDEC      C  RG  CKNL G+F CVC
Sbjct: 574  DLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLC-GRGA-CKNLPGSFRCVC 631

Query: 2237 PPGMR--------------PLP------------------------GSGEGCTDDNECHA 2258
            P G R              P P                        G G  C D +EC  
Sbjct: 632  PAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 691

Query: 2259 QPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ---------GPCFAEVLQTMC 2309
             P  C  GRC NT GSF+C C  GFQP+   +EC D+ +           C        C
Sbjct: 692  SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQC 751

Query: 2310 RSLSSSSEAVTRAEC-----CCGGGRGWGPRCELCPLPGTSAYRKLCPHG----SGYTAE 2360
            R+  S    + R  C     C  G    GP        G+  +R  C  G    SG    
Sbjct: 752  RTCPSGHH-LHRGRCTDVDECSSGAPPCGPHGHCTNTEGS--FRCSCAPGYRAPSGRPGP 808

Query: 2361 GRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLC 2420
              DV+EC        HGEC+N+ GSF C C  GY P     +CLD+DECS+     + +C
Sbjct: 809  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGIC 868

Query: 2421 KNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC--QFLCVNTVGAFTC--RCPPGF 2476
             NT GSF C CP G+    D  +C D+DEC  R         C N+ G++ C   C PG+
Sbjct: 869  TNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 928

Query: 2477 TQHHQ-ACFDNDECSAQ-PGPCGAHGHCHNTPGSFRC--ECHQGFTLVSSGHGCEDVNEC 2532
                +  C D DEC    P  CGA   C NTPGS+RC   C  G+   + G GC+DV+EC
Sbjct: 929  HAGPEGTCDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDEC 986

Query: 2533 DGPHRC-QHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGG 2590
                 C  H  CQN  G ++C C QG+        CVD NEC      CG+A C N  G 
Sbjct: 987  RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1046

Query: 2591 FRCVCP-SGFDFDQALGGCQEVDECAG 2616
            F CVCP S  +FD   G C      AG
Sbjct: 1047 FLCVCPNSPEEFDPMTGRCVPPRTSAG 1073



 Score =  371 bits (953), Expect = e-102
 Identities = 326/1115 (29%), Positives = 438/1115 (39%), Gaps = 234/1115 (20%)

Query: 1297 CLNIPGSFSCRCLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA 1354
            C++ P  ++C C  G+     G  C D+DEC      C+P G C N PGS+RC C  GF 
Sbjct: 494  CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAP-GRCENSPGSFRCVCGPGFR 552

Query: 1355 GD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG- 1411
                   C D DEC      CD G+C N PG + C C  G+       +CQDVDEC Q  
Sbjct: 553  AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 612

Query: 1412 NLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECA-DPVNCINGVCINTPGSYLCS 1470
             LC  G+C+NLPG FRC+C  G+   RG     D++ECA +P  C  G C NT GS+ C+
Sbjct: 613  GLCGRGACKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCA 669

Query: 1471 CPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNP 1530
            CP  F     G  C D                   C+        R+   C+ GR     
Sbjct: 670  CPAGFRSRGPGAPCQDVD----------------ECA--------RSPPPCTYGR----- 700

Query: 1531 CELCPMANTT-EYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCE 1589
            CE     NT   ++ +CP   GFQPN      ED+DEC+     C G +CVN+ GSFQC 
Sbjct: 701  CE-----NTEGSFQCVCP--MGFQPNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCR 752

Query: 1590 -CPPGYHLSEHTRICEDIDECSTHSGICGP-GTCYNTLGNYTCVCPAEYLQVNGGNN-CM 1646
             CP G+HL  H   C D+DECS+ +  CGP G C NT G++ C C   Y   +G    C 
Sbjct: 753  TCPSGHHL--HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCA 810

Query: 1647 DMRKSV----CFRHYNGTCQN-ELAFNVTRKMCCCSYNIGQAWNRPC---------EACP 1692
            D+ + +    CF H  G C N + +F  T   C   Y  G      C         + C 
Sbjct: 811  DVNECLEGDFCFPH--GECLNTDGSFACT---CAPGYRPGPR-GASCLDVDECSEEDLCQ 864

Query: 1693 TPISPD----YQILCGNQAPGFLTDIHTGKPLDIDECGEI-PAICANGICINQIGSFRC- 1746
            + I  +    ++ +C    PG          LD+DEC E  PA+C +  C N  GS+RC 
Sbjct: 865  SGICTNTDGSFECIC---PPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCV 921

Query: 1747 -ECPAGFN---------------YNSILLA----------------------------CE 1762
             +C  G++               Y   +                              C+
Sbjct: 922  RDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ 981

Query: 1763 DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDC 1821
            DVDEC +R S C  +A C N+PGS++C C +GY+ +  G  CV  NEC  +  VC    C
Sbjct: 982  DVDECRNR-SFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALC 1040

Query: 1822 MDTEGSYMCLCHRG--------------------FQASADQTLCMDI-------DECDRQ 1854
             + EGS++C+C                       F  S  Q     +           R+
Sbjct: 1041 ENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR 1100

Query: 1855 PCGNGTCKNIIGSYNCLCFPGFVVTHNGDC-------VDFDECTTLVGQV----CRFGHC 1903
            P  +   +  +GS    C+  F       C       V + EC   VG+     CR   C
Sbjct: 1101 P--STPRQGPVGSGRRECY--FDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQC 1156

Query: 1904 LNT-AGSFHCLCQDGFELTADGKNCV---DTNEC-LSLAGTCLPGTCQNLEGSFRCICPP 1958
              T    +  LC  G    A   +     D +EC L     C  G C N    + C C  
Sbjct: 1157 PGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1216

Query: 1959 GF--QVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC------- 2009
            G+    Q   CID DEC++E   C  G C N+ GS+ C C P  VL  +  RC       
Sbjct: 1217 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQS 1276

Query: 2010 FDTRQSFCFTRFEAG-KCSVPKA-FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQEL 2067
             D     C+    A   CS P+     T T CCC    GE WG  C LCP + S  F+ L
Sbjct: 1277 LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEAL 1334

Query: 2068 C------------------PFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSF-R 2108
            C                  P+ +G   GP             P            G F R
Sbjct: 1335 CNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFAR 1394

Query: 2109 CECPFG---YSLDFTGINCVDTDECSVGHPCGQGTCTNVI-----------------GGF 2148
             E P+G   + +     +     E     P G GT                      G +
Sbjct: 1395 REAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSY 1454

Query: 2149 ECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDV 2208
              + A+ +E      C  +D C+        RC      + C C  GY L      C D+
Sbjct: 1455 AGSLAEPYEELEAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDI 1508

Query: 2209 DECADGQQDCH-ARGMECKNLIGTFACVCPPGMRP 2242
            +EC + +          C N  G+F C+C PG  P
Sbjct: 1509 NECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1543



 Score =  367 bits (943), Expect = e-101
 Identities = 300/982 (30%), Positives = 400/982 (40%), Gaps = 182/982 (18%)

Query: 945  AVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNEC-KVFPGLCTHGTCR 1003
            A + V  ++ P  +    AS    G G+  R+   G        EC    PGL T   C 
Sbjct: 198  APYTVLAQSAPREDGYSDAS----GFGYCFRELRGG--------ECASPLPGLRTQEVC- 244

Query: 1004 NTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGF 1063
                   C  AG             + +C++  +  G    V+ P      C  G+E   
Sbjct: 245  -------CRGAG---------LAWGVHDCQLCSERLGNSERVSAPDG---PCPTGFER-- 283

Query: 1064 MLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL 1123
             +  +C DVDECA     C+ G C NT G Y C CP G  L +  ++C  I +  +S+  
Sbjct: 284  -VNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISEA- 338

Query: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHC--INTEGSYR-CS 1180
               G C  V+    CS       T  +Q C      +    GC + C    +EG    C 
Sbjct: 339  --KGPCFRVLRDGGCSLPILRNIT--KQICCCSRVGKAWGRGCQL-CPPFGSEGFREICP 393

Query: 1181 CGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMAT---------- 1230
             G GY               +E PRV        +P   R     GF+ T          
Sbjct: 394  AGPGYHYSASDLRYNTRPLGQEPPRV-SLSQPRTLPATSRPSA--GFLPTHRLEPRPEPR 450

Query: 1231 PDMR-------------TCVDVDE-------CDLNPHICLHGDCENTKGSFVCHCQLGYM 1270
            PD R             T  ++ E       C  NP +C  G C +    + C C  G+ 
Sbjct: 451  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR 510

Query: 1271 VRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD--GFECHDLDECVSQ 1328
            +    T C DVDEC      C +   C N PGSF C C PG+       EC D+DEC   
Sbjct: 511  LSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC--- 566

Query: 1329 EHRCSP---RGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPG 1383
             HR  P    G C N PGS+ C C  G+  A  G  C+D DEC ++  LC  G C N PG
Sbjct: 567  -HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPG 625

Query: 1384 GYRCECEMGFDPTEDHRAC-QDVDECAQ-GNLCAFGSCENLPGMFRCICNGGYELDRGGG 1441
             +RC C  GF  +    AC +DVDECAQ    C  G C+N  G F C C  G+     G 
Sbjct: 626  SFRCVCPAGFRGS----ACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGA 681

Query: 1442 NCTDINECA-DPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1500
             C D++ECA  P  C  G C NT GS+ C CP  F+ N +G  C D           D  
Sbjct: 682  PCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDV----------DEC 731

Query: 1501 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1560
            ++ ++C                     G  C   P   + + RT CP G      R T  
Sbjct: 732  ENHLACP--------------------GQECVNSP--GSFQCRT-CPSGHHLHRGRCT-- 766

Query: 1561 LEDIDECQE-LPGLCQGGDCVNTFGSFQCECPPGYHL-SEHTRICEDIDECSTHSGICGP 1618
              D+DEC    P     G C NT GSF+C C PGY   S     C D++EC      C P
Sbjct: 767  --DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFP 823

Query: 1619 -GTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCS 1677
             G C NT G++ C C   Y     G +C+D+ +          CQ+ +  N      C  
Sbjct: 824  HGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC----SEEDLCQSGICTNTDGSFEC-- 877

Query: 1678 YNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEI-PAICANGI 1736
                         CP               PG          LD+DEC E  PA+C +  
Sbjct: 878  ------------ICP---------------PGHRAGPDLASCLDVDECRERGPALCGSQR 910

Query: 1737 CINQIGSFRC--ECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRC--KCT 1792
            C N  GS+RC  +C  G++       C+DVDEC            C N PGSYRC   C 
Sbjct: 911  CENSPGSYRCVRDCDPGYHAGP-EGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACD 969

Query: 1793 RGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECD 1852
             GY+ +PGG C   +ECR      +H  C +  GS+ CLC +G++ + D   C+D++EC+
Sbjct: 970  PGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECE 1029

Query: 1853 --RQPCGNGTCKNIIGSYNCLC 1872
              +  CG   C+N+ GS+ C+C
Sbjct: 1030 TLQGVCGAALCENVEGSFLCVC 1051



 Score =  348 bits (894), Expect = 3e-95
 Identities = 306/999 (30%), Positives = 366/999 (36%), Gaps = 223/999 (22%)

Query: 184  TGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTG 243
            TGP   + GP     Q    VC    C   + R  G  C         C  GF  +    
Sbjct: 468  TGPEIPESGPSSGMCQRNPQVCGPGRC---ISRPSGYTCA--------CDSGFRLSPQGT 516

Query: 244  ACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303
             C DVDEC+ VP  C  G C N  GSF C C  G R           RA  C  V     
Sbjct: 517  RCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGP--------RAAECLDV----- 563

Query: 304  CAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGL 363
                      R    CD GRC                                PG F  +
Sbjct: 564  ------DECHRVPPPCDLGRC-----------------------------ENTPGSFLCV 588

Query: 364  LGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGR 423
               G              PHG+                     Q +D C     LC  G 
Sbjct: 589  CPAGYQAA----------PHGASC-------------------QDVDECTQSPGLCGRGA 619

Query: 424  CLPTPSSYRCECNVGYTQDVRGECIDVDECTSSP--CHHGDCVNIPGTYHCRCYPGFQAT 481
            C   P S+RC C  G+      E  DVDEC   P  C  G C N  G++HC C  GF++ 
Sbjct: 620  CKNLPGSFRCVCPAGFRGSACEE--DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSR 677

Query: 482  PTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMC 541
                 C DVDEC  S   C  GRC NTEGSFQCVC  GF+ +  G  C D +EC     C
Sbjct: 678  GPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLAC 737

Query: 542  VNGVCLNEDGSFSC-LCKPGFLLAPGGHYCMDIDECQT--PGICVNGHCTNTEGSFRCQC 598
                C+N  GSF C  C  G  L  G   C D+DEC +  P    +GHCTNTEGSFRC C
Sbjct: 738  PGQECVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 795

Query: 599  LGGLAV--GTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQ 656
              G     G  G  C D +        +E   C   FP         C N D  F   C 
Sbjct: 796  APGYRAPSGRPG-PCADVN------ECLEGDFC---FPHGE------CLNTDGSFA--CT 837

Query: 657  LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAG 716
              P        A C           D++EC+ + ++C +G+C N  GS+ C+C  G+ AG
Sbjct: 838  CAPGYRPGPRGASC----------LDVDECS-EEDLCQSGICTNTDGSFECICPPGHRAG 886

Query: 717  ASGKDCTDVDEC-ALNSLLCDNGWCQNSPGSYSC--SCPPGFHFWQDTEICKDVDECLS- 772
                 C DVDEC      LC +  C+NSPGSY C   C PG+H   +   C DVDEC   
Sbjct: 887  PDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE-GTCDDVDECQEY 945

Query: 773  SPCVSGV--CRNLAGSYTC--KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828
             P + G   C N  GSY C   C PG +  P G  C D         + E R   N    
Sbjct: 946  GPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQD---------VDECR---NRSFC 992

Query: 829  SLRSECCATLGAAWGSPCERCEIDPACARGF-ARMTGVTCDDVNECESFPGVCPNGRCVN 887
               + C    G+              C +G+     G  C DVNECE+  GVC    C N
Sbjct: 993  GAHAVCQNLPGS----------FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCEN 1042

Query: 888  TAGSFRCECPEG-LMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAV 946
              GSF C CP      D     CV  R               T PG            A 
Sbjct: 1043 VEGSFLCVCPNSPEEFDPMTGRCVPPRTS-----------AGTFPGSQPQ--------AP 1083

Query: 947  WGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTV 1006
                  A P P  L      PR     S      R  Y D       P  C +   RN  
Sbjct: 1084 ASPVLPARPPPPPLPRRPSTPRQGPVGS----GRRECYFDT----AAPDACDNILARNVT 1135

Query: 1007 GSFHCACAG-GFALDAQERNC----------------------------TDIDECRISPD 1037
                C   G G+    + + C                             D+DEC++  D
Sbjct: 1136 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRD 1195

Query: 1038 -LCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKC 1096
             +C  G CVNT   + C C  GY      ++ C+D DECA +   C GG C NT GSY C
Sbjct: 1196 QVCKSGVCVNTAPGYSCYCSNGYYYHTQRLE-CIDNDECADEEPACEGGRCVNTVGSYHC 1254

Query: 1097 QCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGA 1135
             C P   L      C   +  SL D L   G C   +GA
Sbjct: 1255 TCEPPLVLDGSQRRCVSNESQSLDDNL---GVCWQEVGA 1290



 Score =  346 bits (888), Expect = 2e-94
 Identities = 344/1150 (29%), Positives = 440/1150 (38%), Gaps = 192/1150 (16%)

Query: 117  GSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQP-----ICDRGCHNGGRCIGPNRCACVY 171
            GS C+ +C      R A+ +      G   G P     +C   CHNGG C+ P+RC C  
Sbjct: 51   GSRCTPTCAP----RNATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRCLCPP 106

Query: 172  GFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHP 231
             F G  C+         G   P      LT  V T  L         G+   +     HP
Sbjct: 107  DFAGKFCQLH-----SSGARPPAPAVPGLTRSVYTMPLANHR-DDEHGVASMVSVHVEHP 160

Query: 232  CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
                 +  +H      V+            +      +        + +   SA  ED  
Sbjct: 161  QEASVV--VH-----QVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGY 213

Query: 292  AGA-----CFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLC 346
            + A     CF  L GG CA  L G  T+  CC   G  W                  QLC
Sbjct: 214  SDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDC-------------QLC 260

Query: 347  AQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLN 406
            ++RL                 S  +  P GP    P G +              G+    
Sbjct: 261  SERLG---------------NSERVSAPDGPC---PTGFERVN-----------GSC--- 288

Query: 407  QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQD-VRGECIDVDECTSSPCHHGDCVN 465
            + +D C      C +G C  T   Y C C  G+  D  R  CI     + +    G C  
Sbjct: 289  EDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEA---KGPCFR 344

Query: 466  IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPD 525
            +     C          T+Q C         G  C L     +EG F+ +C AG    P 
Sbjct: 345  VLRDGGCSL--PILRNITKQICCCSRVGKAWGRGCQLCPPFGSEG-FREICPAG----PG 397

Query: 526  GKNCVDHNECATSTMCVN--GVCLNEDGSFSCLCKP--GFL----LAPGGHYCMDI---D 574
                       T  +      V L++  +     +P  GFL    L P      D     
Sbjct: 398  YHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGP 457

Query: 575  ECQTPGI-CVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPF 633
            E   P I    G      G     C     V   GR C+      TC  A + G    P 
Sbjct: 458  ELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR-CISRPSGYTC--ACDSGFRLSP- 513

Query: 634  PGT--VTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGI---TTDGRDINECAL 688
             GT  +   EC    P    G  C+  P      F+ +C  G        +  D++EC  
Sbjct: 514  QGTRCIDVDECRRVPPPCAPGR-CENSP----GSFRCVCGPGFRAGPRAAECLDVDECHR 568

Query: 689  DPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYS 748
             P  C  G CEN  GS+ CVC  GY+A   G  C DVDEC  +  LC  G C+N PGS+ 
Sbjct: 569  VPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFR 628

Query: 749  CSCPPGFHFWQDTEICKDVDECLSS--PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLD 806
            C CP GF   + +   +DVDEC     PC  G C N AGS+ C C  G R    G  C D
Sbjct: 629  CVCPAGF---RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQD 685

Query: 807  STKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCE--IDPACARGFARMT- 863
                                      EC  +        CE  E      C  GF   T 
Sbjct: 686  V------------------------DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTA 721

Query: 864  GVTCDDVNECESFPGVCPNGRCVNTAGSFRCE-CPEGLMLDASGRLCVDVRLEPCFLRWD 922
            G  C+DV+ECE+    CP   CVN+ GSF+C  CP G  L   GR C DV          
Sbjct: 722  GSECEDVDECENHL-ACPGQECVNSPGSFQCRTCPSGHHLH-RGR-CTDV---------- 768

Query: 923  EDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRP 982
             DEC    P       C  + G+     C   P               G+ +    SGRP
Sbjct: 769  -DECSSGAPPCGPHGHCTNTEGS---FRCSCAP---------------GYRAP---SGRP 806

Query: 983  F-YKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQ 1041
                DVNEC        HG C NT GSF C CA G+    +  +C D+DEC    DLC  
Sbjct: 807  GPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDLCQS 865

Query: 1042 GTCVNTPGSFECECFPGYESGFMLMKNCMDVDEC-ARDPLLCRGGTCTNTDGSYKC--QC 1098
            G C NT GSFEC C PG+ +G  L  +C+DVDEC  R P LC    C N+ GSY+C   C
Sbjct: 866  GICTNTDGSFECICPPGHRAGPDL-ASCLDVDECRERGPALCGSQRCENSPGSYRCVRDC 924

Query: 1099 PPGHELTAKGTACEDIDEC-SLSDGLCPHGQCVNVIGAFQC--SCHAGFQSTPDRQGCVD 1155
             PG+    +GT C+D+DEC      +C   +C N  G+++C  +C  G+Q TP   GC D
Sbjct: 925  DPGYHAGPEGT-CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPG-GGCQD 982

Query: 1156 INECRVQNGGCDVH--CINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCT 1213
            ++ECR     C  H  C N  GS++C C QGY    DGR C DV+ECE    VC    C 
Sbjct: 983  VDECR-NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCE 1041

Query: 1214 NMPGGHRCLC 1223
            N+ G   C+C
Sbjct: 1042 NVEGSFLCVC 1051



 Score =  344 bits (882), Expect = 8e-94
 Identities = 272/913 (29%), Positives = 350/913 (38%), Gaps = 187/913 (20%)

Query: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLG 1626
            CQ  P +C  G C++    + C C  G+ LS     C D+DEC      C PG C N+ G
Sbjct: 482  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 541

Query: 1627 NYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNR 1686
            ++ CVC   +        C+D+ +  C R     C      N      C           
Sbjct: 542  SFRCVCGPGFRAGPRAAECLDVDE--CHR-VPPPCDLGRCENTPGSFLC----------- 587

Query: 1687 PCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRC 1746
                CP                G+    H     D+DEC + P +C  G C N  GSFRC
Sbjct: 588  ---VCPA---------------GYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 629

Query: 1747 ECPAGFNYNSILLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL-SPGGACV 1804
             CPAGF  +    ACE DVDEC     PC     C N  GS+ C C  G++   PG  C 
Sbjct: 630  VCPAGFRGS----ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQ 684

Query: 1805 GRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ-PCGNGTCKN 1863
              +EC   P  C++G C +TEGS+ C+C  GFQ +   + C D+DEC+    C    C N
Sbjct: 685  DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVN 744

Query: 1864 IIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTAD 1923
              GS+ C   P     H G C D DEC++        GHC NT GSF C C  G+   + 
Sbjct: 745  SPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 804

Query: 1924 GKN-CVDTNECLSLAGTCLP-GTCQNLEGSFRCICPPGFQV--QSDHCIDIDECSEEPNL 1979
                C D NECL     C P G C N +GSF C C PG++   +   C+D+DECSEE +L
Sbjct: 805  RPGPCADVNECLE-GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE-DL 862

Query: 1980 CLFGTCTNSPGSFQCLCPPGFVLSDN-------------------GHRCFDTRQSF---- 2016
            C  G CTN+ GSF+C+CPPG     +                     RC ++  S+    
Sbjct: 863  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 922

Query: 2017 -CFTRFEAGK-----------------CSVPKAFNTTKTRCCC-------SKRPGEGWGD 2051
             C   + AG                  C   +  NT  +  C           PG G  D
Sbjct: 923  DCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQD 982

Query: 2052 PCE-----------LCPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNG 2098
              E           +C Q    +FQ LC  G+    G  D R   DVNEC    GVC   
Sbjct: 983  VDECRNRSFCGAHAVC-QNLPGSFQCLCDQGY---EGARDGRHCVDVNECETLQGVCGAA 1038

Query: 2099 -----------VCVNTDGSF-----RCECPFGYSLDFTGIN-----------------CV 2125
                       VC N+   F     RC  P   +  F G                     
Sbjct: 1039 LCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLP 1098

Query: 2126 DTDECSVGHPCGQG------------TCTNVIGGF----ECACADGFEPGLMMTCEDIDE 2169
                     P G G             C N++       EC C  G   G          
Sbjct: 1099 RRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWG--------SG 1150

Query: 2170 CSLNPLLCAFRCHNTE-GSYLCTCPAG---YTLREDGAMCRDVDECADGQQDCHARGMEC 2225
            C +       +C  TE   Y   CP G        D ++ RDVDEC   +      G+ C
Sbjct: 1151 CRIQ------QCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV-C 1203

Query: 2226 KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD----- 2280
             N    ++C C  G        E C D++EC  +   C  GRCVNT GS+ C C+     
Sbjct: 1204 VNTAPGYSCYCSNGYYYHTQRLE-CIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1262

Query: 2281 EGFQPSPTLTECH--DIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL 2338
            +G Q      E    D   G C+ EV   +  S        T  ECCC  G  WG  C L
Sbjct: 1263 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1322

Query: 2339 CPLPGTSAYRKLC 2351
            CP   +  +  LC
Sbjct: 1323 CPAQDSDDFEALC 1335



 Score =  340 bits (873), Expect = 9e-93
 Identities = 195/490 (39%), Positives = 243/490 (49%), Gaps = 46/490 (9%)

Query: 2170 CSLNPLLCA-FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNL 2228
            C  NP +C   RC +    Y C C +G+ L   G  C DVDEC      C A G  C+N 
Sbjct: 482  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APG-RCENS 539

Query: 2229 IGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPT 2288
             G+F CVC PG R  P + E C D +ECH  P  C  GRC NT GSF C C  G+Q +P 
Sbjct: 540  PGSFRCVCGPGFRAGPRAAE-CLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPH 598

Query: 2289 LTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYR 2348
               C D+                     +  T++   CG G      C+   LPG+  +R
Sbjct: 599  GASCQDV---------------------DECTQSPGLCGRGA-----CK--NLPGS--FR 628

Query: 2349 KLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDE 2408
             +CP G   +A   DVDEC      C  G C N+ GSF C C AG+        C D+DE
Sbjct: 629  CVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 688

Query: 2409 CSQVPKPCTF-LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGA 2467
            C++ P PCT+  C+NT+GSF C CP G+     G  C+D+DEC +        CVN+ G+
Sbjct: 689  CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGS 748

Query: 2468 FTCR-CPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHG- 2525
            F CR CP G   H   C D DECS+   PCG HGHC NT GSFRC C  G+   S   G 
Sbjct: 749  FQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 808

Query: 2526 CEDVNEC-DGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSAS 2583
            C DVNEC +G     HG C N  G + C+C  G+    + A C+D +EC+     C S  
Sbjct: 809  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDLCQSGI 867

Query: 2584 CRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPC---SYSCANTPGGFLC--GCPQ 2638
            C NT G F C+CP G      L  C +VDEC   RGP    S  C N+PG + C   C  
Sbjct: 868  CTNTDGSFECICPPGHRAGPDLASCLDVDECR-ERGPALCGSQRCENSPGSYRCVRDCDP 926

Query: 2639 GYFRAGQGHC 2648
            GY    +G C
Sbjct: 927  GYHAGPEGTC 936



 Score =  291 bits (745), Expect = 6e-78
 Identities = 336/1223 (27%), Positives = 443/1223 (36%), Gaps = 283/1223 (23%)

Query: 33   WDGA-LEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCP---GWRTFPGRSQCV-VPICR 87
            W G  +  +GP     + +P +  GP  C SR   Y C    G+R  P  ++C+ V  CR
Sbjct: 467  WTGPEIPESGPSSGMCQRNPQVC-GPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECR 525

Query: 88   RA-------------------CGEGFCSQPNLCTCAD----GTLAPSCGVSRGSGCSVSC 124
            R                    CG GF + P    C D      + P C + R       C
Sbjct: 526  RVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR-------C 578

Query: 125  MNGGTCRGASCLCQKGYTGTVCGQP------------ICDRG-CHNGGRCIGPNRCACVY 171
             N  T     C+C  GY     G              +C RG C N     G  RC C  
Sbjct: 579  EN--TPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKN---LPGSFRCVCPA 633

Query: 172  GFMGPQCERDY-----RTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
            GF G  CE D         PC    GP  C +      C                   CP
Sbjct: 634  GFRGSACEEDVDECAQEPPPC----GPGRCDNTAGSFHCA------------------CP 671

Query: 227  AQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286
            A       GF        CQDVDEC   P  C  G C N  GSF C CP+G + + + + 
Sbjct: 672  A-------GFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE 724

Query: 287  CEDYR---------AGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPR 337
            CED              C +     +C    +GH+  R  C D   C +  P    C P 
Sbjct: 725  CEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPP---CGPH 781

Query: 338  G-----SNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS 392
            G        F+  CA      PG+                                  PS
Sbjct: 782  GHCTNTEGSFRCSCA------PGYRA--------------------------------PS 803

Query: 393  LGPGNSNIGTATLNQTIDICRHFTNLCL-NGRCLPTPSSYRCECNVGYTQDVRG-ECIDV 450
              PG      A +N+ ++      + C  +G CL T  S+ C C  GY    RG  C+DV
Sbjct: 804  GRPGPC----ADVNECLE-----GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDV 854

Query: 451  DECTSSP-CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSG-GLCHLGRCVNT 508
            DEC+    C  G C N  G++ C C PG +A P   +C+DVDEC   G  LC   RC N+
Sbjct: 855  DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENS 914

Query: 509  EGSFQCV--CNAGFELSPDGKNCVDHNECAT--STMCVNGVCLNEDGSFSCL--CKPGFL 562
             GS++CV  C+ G+   P+G  C D +EC      +C    C N  GS+ C   C PG+ 
Sbjct: 915  PGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ 973

Query: 563  LAPGGHYCMDIDECQTPGIC-VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCY 621
              PGG  C D+DEC+    C  +  C N  GSF+C C  G     DGR CVD +   T  
Sbjct: 974  PTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1032

Query: 622  GAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLC-PAKDSA------EFQALCSSGL 674
            G      C       +    C C N    F      C P + SA      + QA  S  L
Sbjct: 1033 GVCGAALCENVEGSFL----CVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVL 1088

Query: 675  ------------------GITTDGRDINECALD---PEVCANGVCENLRGSYRCVCNLG- 712
                              G    GR   EC  D   P+ C N +  N+     C C +G 
Sbjct: 1089 PARPPPPPLPRRPSTPRQGPVGSGR--RECYFDTAAPDACDNILARNVTWQ-ECCCTVGE 1145

Query: 713  -YEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL 771
             + +G   + C   +     SL C +G    +P               D  + +DVDEC 
Sbjct: 1146 GWGSGCRIQQCPGTETAEYQSL-CPHGRGYLAPSG-------------DLSLRRDVDECQ 1191

Query: 772  ---SSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828
                  C SGVC N A  Y+C C  G         C+D+ +       +E  CE      
Sbjct: 1192 LFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDE----CADEEPACE------ 1241

Query: 829  SLRSECCATLGAAWGSPCER-CEIDPACARGFARMTGVTCDDVNECESFPG---VCPNGR 884
                 C  T+G+ +   CE    +D +  R  +  +    D++  C    G   VC + R
Sbjct: 1242 --GGRCVNTVGS-YHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPR 1298

Query: 885  CVNTAGSFRCECPEGLMLDASGRLC-----------VDVRLEPCFLRWDEDECGVTLPGK 933
                A    C C  G        LC            +V   P +        G  LP +
Sbjct: 1299 LDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYS--PPRPGGFGLPYE 1356

Query: 934  YRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYK-------- 985
            Y  D+     G  +G E      P +L +    P    FA R+   G P +         
Sbjct: 1357 YGPDLGPPYQGLPYGPELYP---PPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDG 1413

Query: 986  ---DVNECKVFPGLCTHGT--CRNTVGSFH--------CACAGGFALDAQERNCTDIDEC 1032
                 +E    PG  T      R+T  SF          + AG  A   +E    + +EC
Sbjct: 1414 GPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEE---LEAEEC 1470

Query: 1033 RISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDEC----ARDPLLCRGGTCT 1088
             I  D C  G CV  P  F C CF GY      M  C+D++EC    A  PL C    C 
Sbjct: 1471 GIL-DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMA-CVDINECDEAEAASPL-CVNARCL 1527

Query: 1089 NTDGSYKCQCPPGHELTAKGTAC 1111
            NTDGS++C C PG   T +   C
Sbjct: 1528 NTDGSFRCICRPGFAPTHQPHHC 1550



 Score =  247 bits (630), Expect = 1e-64
 Identities = 176/548 (32%), Positives = 224/548 (40%), Gaps = 54/548 (9%)

Query: 2152 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC 2211
            C  GFE  +  +CED+DEC+         C NT G Y C CP G+ L    + C      
Sbjct: 277  CPTGFER-VNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 335

Query: 2212 ADGQQDCHA--RGMEC-----KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCV 2264
            ++ +  C    R   C     +N+     C    G       G GC           LC 
Sbjct: 336  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGK----AWGRGC----------QLCP 381

Query: 2265 NGRCVNTAGSFRCDCDEG----FQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEA-- 2318
                   +  FR  C  G    +  S        + Q P    + Q      +S   A  
Sbjct: 382  PFG----SEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 437

Query: 2319 --VTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAH 2376
                R E          P  EL PLP   A+      G      G     C+    +C  
Sbjct: 438  LPTHRLEPRPEPRPDPRPGPEL-PLPSIPAWT-----GPEIPESGPSSGMCQRNPQVCGP 491

Query: 2377 GECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCT-FLCKNTKGSFLCSCPRGY 2435
            G CI+    + C C +G+      T C+D+DEC +VP PC    C+N+ GSF C C  G+
Sbjct: 492  GRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGF 551

Query: 2436 LLEEDGRTCKDLDECTSRQHNCQF-LCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQ 2492
                    C D+DEC      C    C NT G+F C CP G+    H  +C D DEC+  
Sbjct: 552  RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQS 611

Query: 2493 PGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNEC-DGPHRCQHG-CQNQLGGY 2549
            PG CG  G C N PGSFRC C  GF     G  CE DV+EC   P  C  G C N  G +
Sbjct: 612  PGLCG-RGACKNLPGSFRCVCPAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSF 666

Query: 2550 RCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQ 2609
             C+CP GF      A C D +ECA SPP C    C NT G F+CVCP GF  + A   C+
Sbjct: 667  HCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE 726

Query: 2610 EVDECAGRRGPCSYSCANTPGGFLC-GCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELL 2668
            +VDEC          C N+PG F C  CP G+    +G C      S G           
Sbjct: 727  DVDECENHLACPGQECVNSPGSFQCRTCPSGH-HLHRGRCTDVDECSSGAPPCGPHGHCT 785

Query: 2669 SSEACYEC 2676
            ++E  + C
Sbjct: 786  NTEGSFRC 793



 Score =  238 bits (608), Expect = 5e-62
 Identities = 166/497 (33%), Positives = 215/497 (43%), Gaps = 72/497 (14%)

Query: 2198 LREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV------CPPGMRPLPGSGEGCT 2251
            LR     CR     A G  DC      C   +G    V      CP G   + GS   C 
Sbjct: 238  LRTQEVCCRGAG-LAWGVHDCQL----CSERLGNSERVSAPDGPCPTGFERVNGS---CE 289

Query: 2252 DDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC---HDIRQ--GPCFAEVLQ 2306
            D +EC A    C +G C NT G + C C +GF    + + C   H I +  GPCF  +  
Sbjct: 290  DVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRD 348

Query: 2307 TMCRSLSSSSEAVTRAECCCGG-GRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRD-- 2363
              C SL      +T+  CCC   G+ WG  C+LCP  G+  +R++CP G GY     D  
Sbjct: 349  GGC-SLPILRN-ITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLR 406

Query: 2364 --------------VDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
                          + + R L            L + R   +    PD      L +   
Sbjct: 407  YNTRPLGQEPPRVSLSQPRTLP--ATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSI 464

Query: 2410 -----SQVPK--PCTFLCK------------NTKGSFLCSCPRGYLLEEDGRTCKDLDEC 2450
                  ++P+  P + +C+            +    + C+C  G+ L   G  C D+DEC
Sbjct: 465  PAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDEC 524

Query: 2451 TSRQHNC-QFLCVNTVGAFTCRCPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPG 2507
                  C    C N+ G+F C C PGF    +A  C D DEC   P PC   G C NTPG
Sbjct: 525  RRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL-GRCENTPG 583

Query: 2508 SFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQ 2565
            SF C C  G+     G  C+DV+EC   P  C  G C+N  G +RC CP GF    + + 
Sbjct: 584  SFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSA 639

Query: 2566 C-VDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYS 2624
            C  D +ECA  PP CG   C NT G F C CP+GF        CQ+VDECA    PC+Y 
Sbjct: 640  CEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYG 699

Query: 2625 -CANTPGGFLCGCPQGY 2640
             C NT G F C CP G+
Sbjct: 700  RCENTEGSFQCVCPMGF 716



 Score =  137 bits (345), Expect = 1e-31
 Identities = 112/393 (28%), Positives = 147/393 (37%), Gaps = 57/393 (14%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR-CELCPLPGTSAYRKLCPHGSG 2356
            G CF E+    C S        T+  CC G G  WG   C+LC     ++ R   P G  
Sbjct: 220  GYCFRELRGGECASPLPGLR--TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPC 277

Query: 2357 YTAEGR------DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECS 2410
             T   R      DVDEC      C HGEC N+ G + C C  G+  D++ ++C+     S
Sbjct: 278  PTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVIS 336

Query: 2411 QVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTC 2470
            +   PC  + ++      CS P    + +    C  + +   R   CQ         F  
Sbjct: 337  EAKGPCFRVLRDGG----CSLPILRNITKQICCCSRVGKAWGR--GCQLCPPFGSEGFRE 390

Query: 2471 RCPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPGSFR------------------ 2510
             CP G   H+ A     N     Q  P  +       P + R                  
Sbjct: 391  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR 450

Query: 2511 -------------CECHQGFTLVSSGHG---CEDVNECDGPHRCQHGCQNQLGGYRCSCP 2554
                              G  +  SG     C+   +  GP R    C ++  GY C+C 
Sbjct: 451  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR----CISRPSGYTCACD 506

Query: 2555 QGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC 2614
             GF    Q  +C+D +EC   PP C    C N+ G FRCVC  GF        C +VDEC
Sbjct: 507  SGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC 566

Query: 2615 AGRRGPCSYS-CANTPGGFLCGCPQGYFRAGQG 2646
                 PC    C NTPG FLC CP GY  A  G
Sbjct: 567  HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 599



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 5/87 (5%)

Query: 1113 DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG----CDV 1168
            + +EC + DG C +G+CV V   F C C  G++    R  CVDINEC           + 
Sbjct: 1466 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 1169 HCINTEGSYRCSCGQGYSLMPDGRACA 1195
             C+NT+GS+RC C  G++       CA
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHCA 1551



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 35/88 (39%), Positives = 44/88 (50%), Gaps = 7/88 (7%)

Query: 1885 VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNEC---LSLAGTCL 1941
            ++ +EC  L G  C  G C+     F C C DG+ L      CVD NEC    + +  C+
Sbjct: 1465 LEAEECGILDG--CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1522

Query: 1942 PGTCQNLEGSFRCICPPGFQV--QSDHC 1967
               C N +GSFRCIC PGF    Q  HC
Sbjct: 1523 NARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 32/93 (34%), Positives = 42/93 (45%), Gaps = 4/93 (4%)

Query: 530  VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ----TPGICVNG 585
            ++  EC     C NG C+     F+C C  G+ L      C+DI+EC        +CVN 
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 586  HCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS 618
             C NT+GSFRC C  G A       C     R+
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1557



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 32/91 (35%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1928 VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPN---LCLF 1982
            ++  EC  L G C  G C  +   F C C  G+++      C+DI+EC E      LC+ 
Sbjct: 1465 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523

Query: 1983 GTCTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013
              C N+ GSF+C+C PGF  +   H C   R
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 56/220 (25%), Positives = 82/220 (37%), Gaps = 24/220 (10%)

Query: 8   LARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAY 67
           +AR   A    A +    +A    R DG  +A+G G   R    G    P + G R    
Sbjct: 185 VARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASP-LPGLRTQEV 243

Query: 68  CCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVS-CMN 126
           CC G     G   C      + C E   +   + +  DG          GS   V  C  
Sbjct: 244 CCRGAGLAWGVHDC------QLCSERLGNSERV-SAPDGPCPTGFERVNGSCEDVDECAT 296

Query: 127 GGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGP 186
           GG C+   C   +G    VC            G  +  +R +C+   +  + +     GP
Sbjct: 297 GGRCQHGECANTRGGYTCVCPD----------GFLLDSSRSSCISQHVISEAK-----GP 341

Query: 187 CFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
           CF  +   GC   +   +  +  CC+ VG+AWG  C+LCP
Sbjct: 342 CFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 381



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 5/99 (5%)

Query: 1141 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1200
            +AG  + P  +  ++  EC + +G  +  C+     + C C  GY L     AC D++EC
Sbjct: 1454 YAGSLAEPYEE--LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINEC 1511

Query: 1201 EENPR---VCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236
            +E      +C    C N  G  RC+C  GF  T     C
Sbjct: 1512 DEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 33/90 (36%), Positives = 40/90 (44%), Gaps = 13/90 (14%)

Query: 1318 ECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGD--GFFCEDRDECAENV---DL 1372
            EC  LD C +        G C+ VP  + C C  G+  D     C D +EC E      L
Sbjct: 1469 ECGILDGCTN--------GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL 1520

Query: 1373 CDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402
            C N +CLN  G +RC C  GF PT     C
Sbjct: 1521 CVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 36/95 (37%), Positives = 43/95 (45%), Gaps = 13/95 (13%)

Query: 2205 CRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNEC---HAQPD 2261
            C  +D C +G+         C  +   F C C  G R L  +   C D NEC    A   
Sbjct: 1470 CGILDGCTNGR---------CVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASP 1519

Query: 2262 LCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296
            LCVN RC+NT GSFRC C  GF P+     C   R
Sbjct: 1520 LCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 1082 CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDG---LCPHGQCVNVIGAFQC 1138
            C  G C      + C+C  G+ L     AC DI+EC  ++    LC + +C+N  G+F+C
Sbjct: 1476 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRC 1535

Query: 1139 SCHAGFQSTPDRQGC 1153
             C  GF  T     C
Sbjct: 1536 ICRPGFAPTHQPHHC 1550



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 31/94 (32%), Positives = 41/94 (43%), Gaps = 11/94 (11%)

Query: 2352 PHGSGYTA------EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLD 2405
            P G  Y        E  + +EC +L   C +G C+     F C C  GY  D T   C+D
Sbjct: 1449 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1507

Query: 2406 MDECSQV----PKPCTFLCKNTKGSFLCSCPRGY 2435
            ++EC +     P      C NT GSF C C  G+
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1541



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 1563 DIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDEC---STHSGICGPG 1619
            + +EC  L G C  G CV     F C C  GY L      C DI+EC      S +C   
Sbjct: 1466 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 1620 TCYNTLGNYTCVCPAEYLQVNGGNNCMDMR 1649
             C NT G++ C+C   +   +  ++C   R
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 35/114 (30%), Positives = 47/114 (41%), Gaps = 18/114 (15%)

Query: 1224 YDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
            Y G +A P     ++ +EC +    C +G C      F C C  GY +      C D++E
Sbjct: 1454 YAGSLAEPYEE--LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE 1510

Query: 1284 C---EVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSP 1334
            C   E     C  +A CLN  GSF C C PG+               Q H C+P
Sbjct: 1511 CDEAEAASPLC-VNARCLNTDGSFRCICRPGFAP-----------THQPHHCAP 1552



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 28/76 (36%), Positives = 35/76 (46%), Gaps = 4/76 (5%)

Query: 2528 DVNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENEC---ALSPPTCGSAS 2583
            +  EC     C +G C     G+ C C  G+        CVD NEC     + P C +A 
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525

Query: 2584 CRNTLGGFRCVCPSGF 2599
            C NT G FRC+C  GF
Sbjct: 1526 CLNTDGSFRCICRPGF 1541



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 29/85 (34%), Positives = 35/85 (41%), Gaps = 7/85 (8%)

Query: 2487 DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-----GPHRCQHG 2541
            +EC    G C  +G C   P  F C C  G+ L  +   C D+NECD      P      
Sbjct: 1468 EECGILDG-C-TNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525

Query: 2542 CQNQLGGYRCSCPQGFTQHSQWAQC 2566
            C N  G +RC C  GF    Q   C
Sbjct: 1526 CLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 26/82 (31%), Positives = 35/82 (42%), Gaps = 4/82 (4%)

Query: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL--- 2460
            L+ +EC  +       C      F C C  GY L+     C D++EC   +         
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 2461 -CVNTVGAFTCRCPPGFTQHHQ 2481
             C+NT G+F C C PGF   HQ
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQ 1546



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 31/90 (34%), Positives = 38/90 (42%), Gaps = 6/90 (6%)

Query: 830  LRSECCATLGAAWGSPCERCE--IDPACARGFAR-MTGVTCDDVNEC---ESFPGVCPNG 883
            L +E C  L       C R        C  G+   MT + C D+NEC   E+   +C N 
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
            RC+NT GSFRC C  G         C   R
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1554



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 8/101 (7%)

Query: 2554 PQGFTQHSQWAQCVDE---NECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQE 2610
            P+G +     A+  +E    EC +    C +  C     GF C C  G+  D     C +
Sbjct: 1449 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1507

Query: 2611 VDEC--AGRRGPCSYS--CANTPGGFLCGCPQGYFRAGQGH 2647
            ++EC  A    P   +  C NT G F C C  G+    Q H
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPH 1548



 Score = 40.4 bits (93), Expect = 0.025
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 3/61 (4%)

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPG---LCQGGDCVNTFGSFQCECPPGYHLSEHTRI 1602
            C   +G++ +   +   DI+EC E      LC    C+NT GSF+C C PG+  +     
Sbjct: 1490 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHH 1549

Query: 1603 C 1603
            C
Sbjct: 1550 C 1550



 Score = 38.9 bits (89), Expect = 0.072
 Identities = 14/34 (41%), Positives = 21/34 (61%)

Query: 2363 DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTP 2396
            + DE    + LC +  C+N+ GSFRC C+ G+ P
Sbjct: 1510 ECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1543



 Score = 37.4 bits (85), Expect = 0.21
 Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 11/94 (11%)

Query: 247  DVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDY----RAGACFSVLFGG 302
            + +EC  + G C  G CV +   F CRC  G+RL  +  AC D      A A   +    
Sbjct: 1466 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524

Query: 303  RCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPP 336
            RC  +  G +   +C C  G  +A    P  C P
Sbjct: 1525 RCL-NTDGSF---RCICRPG--FAPTHQPHHCAP 1552



 Score = 36.6 bits (83), Expect = 0.36
 Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 3/66 (4%)

Query: 232  CRRGFIPNIHTGACQDVDEC---QAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACE 288
            C  G+  ++   AC D++EC   +A   LC    C+N  GSF C C  G   +     C 
Sbjct: 1492 CFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCA 1551

Query: 289  DYRAGA 294
              R  A
Sbjct: 1552 PARPRA 1557



 Score = 36.2 bits (82), Expect = 0.47
 Identities = 15/37 (40%), Positives = 19/37 (51%)

Query: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
            D C NGRCV     F C C +G++   T   C DI +
Sbjct: 1474 DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE 1510



 Score = 32.0 bits (71), Expect = 8.8
 Identities = 37/130 (28%), Positives = 47/130 (36%), Gaps = 24/130 (18%)

Query: 18  LAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPG 77
           L W +LL +    G   G        RVR          P VCG R    C  G    P 
Sbjct: 7   LLWVSLLVLLAQLGPQPGLGRLGERLRVRFT--------PVVCGLR----CVHG----PT 50

Query: 78  RSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTC-RGASCL 136
            S+C  P C         +  ++ + A G  AP     R   C + C NGG C +   CL
Sbjct: 51  GSRCT-PTCAPR------NATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRCL 103

Query: 137 CQKGYTGTVC 146
           C   + G  C
Sbjct: 104 CPPDFAGKFC 113


>gi|110347412 latent transforming growth factor beta binding protein 4
            isoform b [Homo sapiens]
          Length = 1587

 Score =  581 bits (1497), Expect = e-165
 Identities = 439/1396 (31%), Positives = 570/1396 (40%), Gaps = 207/1396 (14%)

Query: 620  CYGAIEKGSCARPFPGTVTKSECCCANPDHGFG-EPCQLCPAK--DSAEFQAL---CSSG 673
            C+  +  G CA P PG  T+ E CC      +G   CQLC  +  +S    A    C +G
Sbjct: 252  CFRELRGGECASPLPGLRTQ-EVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 310

Query: 674  LG-ITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNS 732
               +     D++ECA     C +G C N RG Y CVC  G+   +S   C  + +  ++ 
Sbjct: 311  FERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE 367

Query: 733  LLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGS---YTC 789
                 G C        CS P   +  +    C  V +     C   +C           C
Sbjct: 368  A---KGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQ--LCPPFGSEGFREIC 422

Query: 790  KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVN----LQGASLRSECCATLGAAWGSP 845
              GPG     S     D    T  L  +  R  ++    L   S  S            P
Sbjct: 423  PAGPGYHYSAS-----DLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRP 477

Query: 846  CERCEIDPACARGFARMTGVTCDDVNE-------CESFPGVCPNGRCVNTAGSFRCECPE 898
              R +  P        +   T  ++ E       C+  P VC  GRC++    + C C  
Sbjct: 478  EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDS 537

Query: 899  GLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPE 958
            G  L   G  C+DV           DEC    P         C+ G      CE  P   
Sbjct: 538  GFRLSPQGTRCIDV-----------DECRRVPPP--------CAPG-----RCENSPG-- 571

Query: 959  SLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFA 1018
               F  +C  G     R          DV+EC   P  C  G C NT GSF C C  G+ 
Sbjct: 572  --SFRCVCGPGFRAGPR-----AAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQ 624

Query: 1019 LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARD 1078
                  +C D+DEC  SP LCG+G C N PGSF C C  G+           DVDECA++
Sbjct: 625  AAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE----DVDECAQE 680

Query: 1079 PLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQC 1138
            P  C  G C NT GS+ C CP G      G  C+D+DEC+ S   C +G+C N  G+FQC
Sbjct: 681  PPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQC 740

Query: 1139 SCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRC-SCGQGYSLMPDGRACADV 1197
             C  GFQ       C D++EC          C+N+ GS++C +C  G+ L   GR C DV
Sbjct: 741  VCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHR-GR-CTDV 798

Query: 1198 DECEENPRVCD-QGHCTNMPGGHRCLCYDGFMATPDMRT--CVDVDECDLNPHICL-HGD 1253
            DEC      C   GHCTN  G  RC C  G+ A P  R   C DV+EC L    C  HG+
Sbjct: 799  DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRA-PSGRPGPCADVNEC-LEGDFCFPHGE 856

Query: 1254 CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWV 1313
            C NT GSF C C  GY        C DVDEC      C S   C N  GSF C C PG  
Sbjct: 857  CLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDL-CQS-GICTNTDGSFECICPPGHR 914

Query: 1314 G--DGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCT--CRQGF-AGDGFFCEDRDECAE 1368
               D   C D+DEC  +         C N PGSYRC   C  G+ AG    C+D DEC E
Sbjct: 915  AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQE 974

Query: 1369 -NVDLCDNGQCLNAPGGYRCE--CEMGFDPTEDHRACQDVDECAQGNLC-AFGSCENLPG 1424
               ++C   +C N PG YRC   C+ G+ PT     CQDVDEC   + C A   C+NLPG
Sbjct: 975  YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPG 1033

Query: 1425 MFRCICNGGYELDRGGGNCTDINECADPVN-CINGVCINTPGSYLCSCPQD-FELNPSGV 1482
             F+C+C+ GYE  R G +C D+NEC      C   +C N  GS+LC CP    E +P   
Sbjct: 1034 SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG 1093

Query: 1483 GCVDTRAG-------------------------------------------NCFLETHDR 1499
             CV  R                                              C+ +T   
Sbjct: 1094 RCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTA-- 1151

Query: 1500 GDSGISCSAEIGVGVTRASCCCSLGRAWGNPCEL--CPMANTTEYRTLCPGGEGF-QPNR 1556
              +  +C   +   VT   CCC++G  WG+ C +  CP   T EY++LCP G G+  P+ 
Sbjct: 1152 --APDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSG 1209

Query: 1557 ITVILEDIDECQELPG-LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGI 1615
               +  D+DECQ     +C+ G CVNT   + C C  GY+       C D DEC+     
Sbjct: 1210 DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPA 1269

Query: 1616 CGPGTCYNTLGNYTCVCPAEYLQVNGGNNC-------MDMRKSVCFRHYNG--TCQN-EL 1665
            C  G C NT+G+Y C C    +       C       +D    VC++       C +  L
Sbjct: 1270 CEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRL 1329

Query: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAP---------GF------ 1710
                T   CCC Y  G+AW   C  CP   S D++ LC    P         GF      
Sbjct: 1330 DRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEY 1387

Query: 1711 ---LTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC 1767
               L   + G P    E    PA+  +          R E P G     +    +D    
Sbjct: 1388 GPDLGPPYQGLPYG-PELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPY 1446

Query: 1768 GSRESPCQQNADCINIPGS---YRCKCTRGYKLSP-----GGACVG----------RNEC 1809
            G  E+P          PG+   YR + TR     P     GG+  G            EC
Sbjct: 1447 GESEAPAPPG------PGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEEC 1500

Query: 1810 REIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP-----CGNGTCKNI 1864
              I + C++G C+     + C C  G++    +  C+DI+ECD        C N  C N 
Sbjct: 1501 -GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1559

Query: 1865 IGSYNCLCFPGFVVTH 1880
             GS+ C+C PGF  TH
Sbjct: 1560 DGSFRCICRPGFAPTH 1575



 Score =  538 bits (1386), Expect = e-152
 Identities = 356/1161 (30%), Positives = 481/1161 (41%), Gaps = 168/1161 (14%)

Query: 810  GTCWLKIQESRCEVNLQGASLRSECCATLGAAWG-SPCERCEI-----------DPACAR 857
            G C+ +++   C   L G   +  CC   G AWG   C+ C             D  C  
Sbjct: 250  GYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPT 309

Query: 858  GFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRL--- 914
            GF R+ G +C+DV+EC +  G C +G C NT G + C CP+G +LD+S   C+   +   
Sbjct: 310  GFERVNG-SCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISE 367

Query: 915  --EPCFLRWDEDECGVTLPGKYRMDVCCCS-IGAVWGVECEACPDPESLEFASLCPRGLG 971
               PCF    +  C + +       +CCCS +G  WG  C+ CP   S  F  +CP G G
Sbjct: 368  AKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPG 427

Query: 972  F---ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVG--------------------- 1007
            +   AS    + RP  ++     +        T R + G                     
Sbjct: 428  YHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGP 487

Query: 1008 SFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM- 1066
                     +       +      C+ +P +CG G C++ P  + C C    +SGF L  
Sbjct: 488  ELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCAC----DSGFRLSP 543

Query: 1067 --KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLC 1124
                C+DVDEC R P  C  G C N+ GS++C C PG     +   C D+DEC      C
Sbjct: 544  QGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC 603

Query: 1125 PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCD-VHCINTEGSYRCSCGQ 1183
              G+C N  G+F C C AG+Q+ P    C D++EC    G C    C N  GS+RC C  
Sbjct: 604  DLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPA 663

Query: 1184 GYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC 1242
            G+     G AC  DVDEC + P  C  G C N  G   C C  GF +      C DVDEC
Sbjct: 664  GFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC 719

Query: 1243 DLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPG 1302
              +P  C +G CENT+GSF C C +G+      + C DVDECE   H       C+N PG
Sbjct: 720  ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE--NHLACPGQECVNSPG 777

Query: 1303 SFSCR-CLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF---AGDGF 1358
            SF CR C  G       C D+DEC S    C P G C N  GS+RC+C  G+   +G   
Sbjct: 778  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 837

Query: 1359 FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS 1418
             C D +EC E      +G+CLN  G + C C  G+ P     +C DVDEC++ +LC  G 
Sbjct: 838  PCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGI 897

Query: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECAD--PVNCINGVCINTPGSYLC--SCPQD 1474
            C N  G F CIC  G+       +C D++EC +  P  C +  C N+PGSY C   C   
Sbjct: 898  CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPG 957

Query: 1475 FELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELC 1534
            +   P G              T D  D       EI          C   R     CE  
Sbjct: 958  YHAGPEG--------------TCDDVDECQEYGPEI----------CGAQR-----CENT 988

Query: 1535 PMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGY 1594
            P      YR       G+QP       +D+DEC+          C N  GSFQC C  GY
Sbjct: 989  P----GSYRCTPACDPGYQPTP-GGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGY 1043

Query: 1595 HLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVC---PAEYLQVNGGNNC------ 1645
              +   R C D++EC T  G+CG   C N  G++ CVC   P E+  + G   C      
Sbjct: 1044 EGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG--RCVPPRTS 1101

Query: 1646 -------------------------MDMRKSVCFRHYNGTCQNELAFNVTRKMCC----- 1675
                                     +  R S   +   G+ + E  F+      C     
Sbjct: 1102 AGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILA 1161

Query: 1676 -------CSYNIGQAWNRPC--EACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG 1726
                   C   +G+ W   C  + CP   + +YQ LC +               D+DEC 
Sbjct: 1162 RNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQ 1221

Query: 1727 EI-PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785
                 +C +G+C+N    + C C  G+ Y++  L C D DEC   E  C +   C+N  G
Sbjct: 1222 LFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCVNTVG 1280

Query: 1786 SYRCKCTRGYKLSPGGACVGRNECREIPN-------------VCSHGDCMDTEGSYM-CL 1831
            SY C C     L         NE + + +             VCSH   +D + +Y  C 
Sbjct: 1281 SYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH-PRLDRQATYTECC 1339

Query: 1832 CHRGFQASADQTLCMDIDECD 1852
            C  G     D  LC   D  D
Sbjct: 1340 CLYGEAWGMDCALCPAQDSDD 1360



 Score =  453 bits (1166), Expect = e-127
 Identities = 344/1156 (29%), Positives = 457/1156 (39%), Gaps = 260/1156 (22%)

Query: 1430 CNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
            C  G+E  R  G+C D++ECA    C +G C NT G Y C CP  F L+ S   C+    
Sbjct: 307  CPTGFE--RVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 364

Query: 1490 -----GNCFLETHDRGDSGISCSAEIGVGVTRASCCCS-LGRAWGNPC------------ 1531
                 G CF    D G     CS  I   +T+  CCCS +G+AWG  C            
Sbjct: 365  ISEAKGPCFRVLRDGG-----CSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFR 419

Query: 1532 ELCPM-------ANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFG 1584
            E+CP        A+   Y T   G E   P R++     + + + LP   +         
Sbjct: 420  EICPAGPGYHYSASDLRYNTRPLGQE---PPRVS-----LSQPRTLPATSRPSAGFLPTH 471

Query: 1585 SFQC------------ECP----PGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNY 1628
              +             E P    P +   E          C  +  +CGPG C +    Y
Sbjct: 472  RLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGY 531

Query: 1629 TCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPC 1688
            TC C + +     G  C+D+ +                                     C
Sbjct: 532  TCACDSGFRLSPQGTRCIDVDE-------------------------------------C 554

Query: 1689 EACPTPISP--------DYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1740
               P P +P         ++ +CG   PGF       + LD+DEC  +P  C  G C N 
Sbjct: 555  RRVPPPCAPGRCENSPGSFRCVCG---PGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 611

Query: 1741 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLS-- 1798
             GSF C CPAG+       +C+DVDEC      C + A C N+PGS+RC C  G++ S  
Sbjct: 612  PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSAC 670

Query: 1799 --------------------------------------PGGACVGRNECREIPNVCSHGD 1820
                                                  PG  C   +EC   P  C++G 
Sbjct: 671  EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 730

Query: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ-PCGNGTCKNIIGSYNCLCFPGFVVT 1879
            C +TEGS+ C+C  GFQ +   + C D+DEC+    C    C N  GS+ C   P     
Sbjct: 731  CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL 790

Query: 1880 HNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN-CVDTNECLSLAG 1938
            H G C D DEC++        GHC NT GSF C C  G+   +     C D NECL    
Sbjct: 791  HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLE-GD 849

Query: 1939 TCLP-GTCQNLEGSFRCICPPGFQ--VQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCL 1995
             C P G C N +GSF C C PG++   +   C+D+DECSEE +LC  G CTN+ GSF+C+
Sbjct: 850  FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE-DLCQSGICTNTDGSFECI 908

Query: 1996 CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCEL 2055
            CPPG     +   C D  +                         C  + P       CE 
Sbjct: 909  CPPGHRAGPDLASCLDVDE-------------------------CRERGPALCGSQRCEN 943

Query: 2056 CPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAE-NPGVCTNGVCVNTDGSFRC--ECP 2112
             P  GS      C  G+ A  GP+ + +DV+EC E  P +C    C NT GS+RC   C 
Sbjct: 944  SP--GSYRCVRDCDPGYHA--GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACD 999

Query: 2113 FGYSLDFTGINCVDTDECSVGHPCG-QGTCTNVIGGFECACADGFEPGL-MMTCEDIDEC 2170
             GY     G  C D DEC     CG    C N+ G F+C C  G+E       C D++EC
Sbjct: 1000 PGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNEC 1058

Query: 2171 SLNPLLC-AFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
                 +C A  C N EGS+LC CP                   +       R +  +   
Sbjct: 1059 ETLQGVCGAALCENVEGSFLCVCP----------------NSPEEFDPMTGRCVPPRTSA 1102

Query: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
            GTF     PG +P            +  A P L                      P P  
Sbjct: 1103 GTF-----PGSQP------------QAPASPVLPARP-----------------PPPPLP 1128

Query: 2290 TECHDIRQGPC--------FAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL--C 2339
                  RQGP         F       C ++ + +  VT  ECCC  G GWG  C +  C
Sbjct: 1129 RRPSTPRQGPVGSGRRECYFDTAAPDACDNILARN--VTWQECCCTVGEGWGSGCRIQQC 1186

Query: 2340 PLPGTSAYRKLCPHGSGYTAEG------RDVDECRMLA-HLCAHGECINSLGSFRCHCQA 2392
            P   T+ Y+ LCPHG GY A        RDVDEC++    +C  G C+N+   + C+C  
Sbjct: 1187 PGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1246

Query: 2393 GYTPDATATTCLDMDECSQVPKPCT-FLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT 2451
            GY        C+D DEC+     C    C NT GS+ C+C    +L+   R C   +E  
Sbjct: 1247 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQ 1305

Query: 2452 SRQHNCQFLCVNTVGA 2467
            S   N   +C   VGA
Sbjct: 1306 SLDDNLG-VCWQEVGA 1320



 Score =  452 bits (1163), Expect = e-126
 Identities = 378/1156 (32%), Positives = 480/1156 (41%), Gaps = 220/1156 (19%)

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGL-PCELCP----------AQPHPCR 233
            G CF ++    C   L GL  T+ +CC   G AWG+  C+LC           A   PC 
Sbjct: 250  GYCFRELRGGECASPLPGLR-TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 308

Query: 234  RGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA- 292
             GF      G+C+DVDEC A  G CQ G C N  G + C CP G  L  S ++C      
Sbjct: 309  TGF--ERVNGSCEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 365

Query: 293  ----GACFSVLFGGRCAGDLAGHYTRRQCCCDR-GRCWAAGPVPELCPPRGSNEFQQLCA 347
                G CF VL  G C+  +  + T++ CCC R G+ W  G   +LCPP GS  F+++C 
Sbjct: 366  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRG--CQLCPPFGSEGFREIC- 422

Query: 348  QRLPLLPGH-------------------------PGLFPGL----LGFGSNGMGPPLGPA 378
               P  PG+                         P   P       GF       P    
Sbjct: 423  ---PAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEP 479

Query: 379  RLNPHGSDARGIPSL----GPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCE 434
            R +P       +PS+    GP     G ++      +C+    +C  GRC+  PS Y C 
Sbjct: 480  RPDPRPGPELPLPSIPAWTGPEIPESGPSS-----GMCQRNPQVCGPGRCISRPSGYTCA 534

Query: 435  CNVGYTQDVRG-ECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVD 491
            C+ G+    +G  CIDVDEC     PC  G C N PG++ C C PGF+A P    C+DVD
Sbjct: 535  CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVD 594

Query: 492  ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATST-MCVNGVCLNED 550
            EC      C LGRC NT GSF CVC AG++ +P G +C D +EC  S  +C  G C N  
Sbjct: 595  ECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLP 654

Query: 551  GSFSCLCKPGFLLAPGGHYC-MDIDEC-QTPGICVNGHCTNTEGSFRCQCLGGLAVGTDG 608
            GSF C+C  GF     G  C  D+DEC Q P  C  G C NT GSF C C  G      G
Sbjct: 655  GSFRCVCPAGF----RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPG 710

Query: 609  RVC--VDTHVRS---TCYGAIE--KGS----CARPFPGTVTKSEC----CCANPDHGFGE 653
              C  VD   RS     YG  E  +GS    C   F      SEC     C N     G+
Sbjct: 711  APCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQ 770

Query: 654  PCQLCPAKDSAEFQA-LCSSGLGITTDGR--DINECALDPEVCA-NGVCENLRGSYRCVC 709
             C   P      FQ   C SG  +   GR  D++EC+     C  +G C N  GS+RC C
Sbjct: 771  ECVNSP----GSFQCRTCPSGHHLHR-GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 825

Query: 710  NLGYEAGASGK--DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV 767
              GY A  SG+   C DV+EC        +G C N+ GS++C+C PG+        C DV
Sbjct: 826  APGYRA-PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDV 884

Query: 768  DECLSSP-CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQ 826
            DEC     C SG+C N  GS+ C C PG R  P    CLD                    
Sbjct: 885  DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDV------------------- 925

Query: 827  GASLRSECCATLGAAWGSPCERCEIDPA-------CARGFARMTGVTCDDVNECESF-PG 878
                  EC     A  GS  +RCE  P        C  G+      TCDDV+EC+ + P 
Sbjct: 926  -----DECRERGPALCGS--QRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPE 978

Query: 879  VCPNGRCVNTAGSFRC--ECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRM 936
            +C   RC NT GS+RC   C  G      G  C DV           DEC          
Sbjct: 979  ICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDV-----------DEC---------R 1017

Query: 937  DVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGL 996
            +   C   AV    C+  P      F  LC +G    +RD   GR    DVNEC+   G+
Sbjct: 1018 NRSFCGAHAV----CQNLPG----SFQCLCDQGYE-GARD---GR-HCVDVNECETLQGV 1064

Query: 997  CTHGTCRNTVGSFHCAC--------------------AGGFALDAQERNCTDIDECRISP 1036
            C    C N  GSF C C                    AG F     +   + +   R  P
Sbjct: 1065 CGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1124

Query: 1037 DLCGQGTCVNTP-----GSFECECFPGYES----GFMLMKN------CMDVDECARDPLL 1081
                +    +TP     GS   EC+    +      +L +N      C  V E       
Sbjct: 1125 PPLPRRP--STPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSG-- 1180

Query: 1082 CRGGTCTNTD-GSYKCQCPPGHELTAKG---TACEDIDECSL-SDGLCPHGQCVNVIGAF 1136
            CR   C  T+   Y+  CP G    A     +   D+DEC L  D +C  G CVN    +
Sbjct: 1181 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1240

Query: 1137 QCSCHAGFQSTPDRQGCVDINECRVQNGGCD-VHCINTEGSYRCSCGQGYSLMPDGRACA 1195
             C C  G+     R  C+D +EC  +   C+   C+NT GSY C+C     L    R C 
Sbjct: 1241 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1300

Query: 1196 --DVDECEENPRVCDQ 1209
              +    ++N  VC Q
Sbjct: 1301 SNESQSLDDNLGVCWQ 1316



 Score =  442 bits (1137), Expect = e-123
 Identities = 292/923 (31%), Positives = 399/923 (43%), Gaps = 164/923 (17%)

Query: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQ-GNLCAFGSCENLPG 1424
            C  N  +C  G+C++ P GY C C+ GF  +     C DVDEC +    CA G CEN PG
Sbjct: 512  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 571

Query: 1425 MFRCICNGGYELDRGGGNCTDINECAD-PVNCINGVCINTPGSYLCSCPQDFELNPSGVG 1483
             FRC+C  G+        C D++EC   P  C  G C NTPGS+LC CP  ++  P G  
Sbjct: 572  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGAS 631

Query: 1484 CVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYR 1543
            C D                                C  S G      C+  P +    +R
Sbjct: 632  CQDVD-----------------------------ECTQSPGLCGRGACKNLPGS----FR 658

Query: 1544 TLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC 1603
             +CP G      R +   ED+DEC + P  C  G C NT GSF C CP G+        C
Sbjct: 659  CVCPAGF-----RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC 713

Query: 1604 EDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQN 1663
            +D+DEC+     C  G C NT G++ CVCP  +     G+ C D+ +          C+N
Sbjct: 714  QDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE----------CEN 763

Query: 1664 ELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDID 1723
             LA       C     +    +  C  CP+          G+        +H G+  D+D
Sbjct: 764  HLA-------CPGQECVNSPGSFQCRTCPS----------GHH-------LHRGRCTDVD 799

Query: 1724 ECGEIPAICA-NGICINQIGSFRCECPAGFNYNSILLA-CEDVDECGSRESPCQQNADCI 1781
            EC      C  +G C N  GSFRC C  G+   S     C DV+EC   +  C  + +C+
Sbjct: 800  ECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECL 858

Query: 1782 NIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASA 1840
            N  GS+ C C  GY+  P GA C+  +EC E  ++C  G C +T+GS+ C+C  G +A  
Sbjct: 859  NTDGSFACTCAPGYRPGPRGASCLDVDECSE-EDLCQSGICTNTDGSFECICPPGHRAGP 917

Query: 1841 DQTLCMDIDEC-DRQP--CGNGTCKNIIGSYNCL--CFPGFVVTHNGDCVDFDECTTLVG 1895
            D   C+D+DEC +R P  CG+  C+N  GSY C+  C PG+     G C D DEC     
Sbjct: 918  DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 977

Query: 1896 QVCRFGHCLNTAGSFHCL--CQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFR 1953
            ++C    C NT GS+ C   C  G++ T  G  C D +EC + +       CQNL GSF+
Sbjct: 978  EICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQ 1036

Query: 1954 CICPPGFQVQSD--HCIDIDECSEEPNLC-----------LFGTCTNSPGSF-----QCL 1995
            C+C  G++   D  HC+D++EC     +C               C NSP  F     +C+
Sbjct: 1037 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1096

Query: 1996 CPPGFVLSDNGHR-----------------------------CFDTRQSFCFTRFEAGKC 2026
             P     +  G +                                 R+   F       C
Sbjct: 1097 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1156

Query: 2027 SVPKAFNTTKTRCCCSKRPGEGWGDPCEL--CPQEGSAAFQELCPFGHG--AVPGPDDSR 2082
                A N T   CCC+   GEGWG  C +  CP   +A +Q LCP G G  A  G    R
Sbjct: 1157 DNILARNVTWQECCCTV--GEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLR 1214

Query: 2083 EDVNECAE-NPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP-CGQGT 2140
             DV+EC      VC +GVCVNT   + C C  GY      + C+D DEC+   P C  G 
Sbjct: 1215 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1274

Query: 2141 CTNVIGGFECACADGFEPGLMM-----TCEDIDECSLN------------PLLCAFRCHN 2183
            C N +G + C C    EP L++      C   +  SL+             L+C+    +
Sbjct: 1275 CVNTVGSYHCTC----EPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLD 1330

Query: 2184 TEGSYL-CTCPAGYTLREDGAMC 2205
             + +Y  C C  G     D A+C
Sbjct: 1331 RQATYTECCCLYGEAWGMDCALC 1353



 Score =  440 bits (1131), Expect = e-122
 Identities = 363/1186 (30%), Positives = 488/1186 (41%), Gaps = 203/1186 (17%)

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG-NPCELCPMANTTEYRTLCPG 1548
            G CF E       G  C++ +    T+  CC   G AWG + C+LC        R   P 
Sbjct: 250  GYCFRELR-----GGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPD 304

Query: 1549 GEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDE 1608
            G                                        CP G+     +  CED+DE
Sbjct: 305  GP---------------------------------------CPTGFERVNGS--CEDVDE 323

Query: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMR-----KSVCFRHY-NGTCQ 1662
            C+T  G C  G C NT G YTCVCP  +L  +  ++C+        K  CFR   +G C 
Sbjct: 324  CAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCS 382

Query: 1663 NELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGF---LTDI-HTGK 1718
              +  N+T+++CCCS  +G+AW R C+ CP   S  ++ +C    PG+    +D+ +  +
Sbjct: 383  LPILRNITKQICCCS-RVGKAWGRGCQLCPPFGSEGFREICP-AGPGYHYSASDLRYNTR 440

Query: 1719 PLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNA 1778
            PL     G+ P      + ++Q  +     PA    ++  L    + E      P  +  
Sbjct: 441  PL-----GQEPP----RVSLSQPRTL----PATSRPSAGFLPTHRL-EPRPEPRPDPRPG 486

Query: 1779 DCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA 1838
              + +P         G ++   G   G   C+  P VC  G C+     Y C C  GF+ 
Sbjct: 487  PELPLPS---IPAWTGPEIPESGPSSGM--CQRNPQVCGPGRCISRPSGYTCACDSGFRL 541

Query: 1839 SADQTLCMDIDECDR--QPCGNGTCKNIIGSYNCLCFPGFVV-THNGDCVDFDECTTLVG 1895
            S   T C+D+DEC R   PC  G C+N  GS+ C+C PGF       +C+D DEC   V 
Sbjct: 542  SPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHR-VP 600

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI 1955
              C  G C NT GSF C+C  G++    G +C D +EC    G C  G C+NL GSFRC+
Sbjct: 601  PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 660

Query: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
            CP GF+  +    D+DEC++EP  C  G C N+ GSF C CP GF     G  C D  + 
Sbjct: 661  CPAGFRGSACE-EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE- 718

Query: 2016 FCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV 2075
                                     C++ P       CE    EGS  FQ +CP G    
Sbjct: 719  -------------------------CARSPPPCTYGRCE--NTEGS--FQCVCPMGFQPN 749

Query: 2076 PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCE-CPFGYSLDFTGINCVDTDECSVGH 2134
                +  EDV+EC EN   C    CVN+ GSF+C  CP G+ L      C D DECS G 
Sbjct: 750  TAGSEC-EDVDEC-ENHLACPGQECVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGA 805

Query: 2135 P-CG-QGTCTNVIGGFECACADGFEP--GLMMTCEDIDECSLNPLLCAF-RCHNTEGSYL 2189
            P CG  G CTN  G F C+CA G+    G    C D++EC           C NT+GS+ 
Sbjct: 806  PPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFA 865

Query: 2190 CTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249
            CTC  GY     GA C DVDEC++  +D    G+ C N  G+F C+CPPG R  P     
Sbjct: 866  CTCAPGYRPGPRGASCLDVDECSE--EDLCQSGI-CTNTDGSFECICPPGHRAGPDLAS- 921

Query: 2250 CTDDNECHAQ-PDLCVNGRCVNTAGSFRC--DCDEGFQPSPTLT-----ECHDIRQGPCF 2301
            C D +EC  + P LC + RC N+ GS+RC  DCD G+   P  T     EC +     C 
Sbjct: 922  CLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICG 981

Query: 2302 AEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCE---------LCP-LPGTSAYRKLC 2351
            A+  +    S   +       +   GGG      C          +C  LPG+  ++ LC
Sbjct: 982  AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGS--FQCLC 1039

Query: 2352 PHGSGYTAEGR---DVDECRML-----AHLCAHGE------CINSLGSF-----RC---H 2389
              G     +GR   DV+EC  L     A LC + E      C NS   F     RC    
Sbjct: 1040 DQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPR 1099

Query: 2390 CQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDE 2449
              AG  P +           ++ P P                PR       G       E
Sbjct: 1100 TSAGTFPGSQPQAPASPVLPARPPPP--------------PLPRRPSTPRQGPVGSGRRE 1145

Query: 2450 C---TSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTP 2506
            C   T+    C  +    V    C C  G             C  Q  P        +  
Sbjct: 1146 CYFDTAAPDACDNILARNVTWQECCCTVGEGW-------GSGCRIQQCPGTETAEYQSL- 1197

Query: 2507 GSFRCECHQGFTLVSSGHGCE-DVNECD--GPHRCQHG-CQNQLGGYRCSCPQGFTQHSQ 2562
                C   +G+   S       DV+EC       C+ G C N   GY C C  G+  H+Q
Sbjct: 1198 ----CPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1253

Query: 2563 WAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
              +C+D +ECA   P C    C NT+G + C C      D +   C
Sbjct: 1254 RLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1299



 Score =  407 bits (1046), Expect = e-113
 Identities = 296/890 (33%), Positives = 387/890 (43%), Gaps = 112/890 (12%)

Query: 1763 DVDECGSRESPCQQNAD------CINIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNV 1815
            ++ E G     CQ+N        CI+ P  Y C C  G++LSP G  C+  +ECR +P  
Sbjct: 501  EIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPP 560

Query: 1816 CSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDR--QPCGNGTCKNIIGSYNCLCF 1873
            C+ G C ++ GS+ C+C  GF+A      C+D+DEC R   PC  G C+N  GS+ C+C 
Sbjct: 561  CAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCP 620

Query: 1874 PGF-VVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV-DTN 1931
             G+    H   C D DECT   G +C  G C N  GSF C+C  GF     G  C  D +
Sbjct: 621  AGYQAAPHGASCQDVDECTQSPG-LCGRGACKNLPGSFRCVCPAGFR----GSACEEDVD 675

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSP 1989
            EC      C PG C N  GSF C CP GF+ +     C D+DEC+  P  C +G C N+ 
Sbjct: 676  ECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTE 735

Query: 1990 GSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKC----------SVPKAFNTTKTRC 2039
            GSFQC+CP GF  +  G  C D  +          +C          + P   +  + RC
Sbjct: 736  GSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC 795

Query: 2040 -----CCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGV 2094
                 C S  P  G    C     EGS  F+  C  G+ A  G      DVNEC E    
Sbjct: 796  TDVDECSSGAPPCGPHGHCT--NTEGS--FRCSCAPGYRAPSGRPGPCADVNECLEGDFC 851

Query: 2095 CTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACAD 2154
              +G C+NTDGSF C C  GY     G +C+D DECS    C  G CTN  G FEC C  
Sbjct: 852  FPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPP 911

Query: 2155 GFEPGL-MMTCEDIDEC-SLNPLLCAF-RCHNTEGSYLCT--CPAGYTLREDGAMCRDVD 2209
            G   G  + +C D+DEC    P LC   RC N+ GSY C   C  GY    +G  C DVD
Sbjct: 912  GHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT-CDDVD 970

Query: 2210 ECAD-GQQDCHARGMECKNLIGTFACV--CPPGMRPLPGSGEGCTDDNECHAQPDLCVNG 2266
            EC + G + C A+   C+N  G++ C   C PG +P PG G  C D +EC  +     + 
Sbjct: 971  ECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGGG--CQDVDECRNRSFCGAHA 1026

Query: 2267 RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCC 2326
             C N  GSF+C CD+G++ +     C D+ +     E LQ +C +    +   +    C 
Sbjct: 1027 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCVCP 1082

Query: 2327 GGGRGWGPRCELCPLPGTSAY-------------------------RKLCPHGSGYTAEG 2361
                 + P    C  P TSA                          R+      G    G
Sbjct: 1083 NSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSG 1142

Query: 2362 RDVDECRMLAHLCAHGECINSLGSF----RCHCQAGYTPDATATTCLDMDECSQVPKPCT 2417
            R   EC       A   C N L        C C  G   +   + C  + +C     P T
Sbjct: 1143 RR--ECYF--DTAAPDACDNILARNVTWQECCCTVG---EGWGSGCR-IQQC-----PGT 1189

Query: 2418 FLCKNTKGSFLCSCPRGYLLEE-DGRTCKDLDECTS-RQHNCQF-LCVNTVGAFTCRCPP 2474
               +  +   LC   RGYL    D    +D+DEC   R   C+  +CVNT   ++C C  
Sbjct: 1190 ---ETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1246

Query: 2475 GFTQHHQ--ACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC 2532
            G+  H Q   C DNDEC+ +   C   G C NT GS+ C C     L  S   C   NE 
Sbjct: 1247 GYYYHTQRLECIDNDECADEEPACEG-GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NES 1304

Query: 2533 DGPHRCQHGCQNQLGG-YRCSCPQGFTQHSQWAQCVDENE-----CALSP 2576
                     C  ++G    CS P+   Q +    C    E     CAL P
Sbjct: 1305 QSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCP 1354



 Score =  382 bits (981), Expect = e-105
 Identities = 275/840 (32%), Positives = 359/840 (42%), Gaps = 140/840 (16%)

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI 1955
            QVC  G C++    + C C  GF L+  G  C+D +EC  +   C PG C+N  GSFRC+
Sbjct: 517  QVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCV 576

Query: 1956 CPPGFQV--QSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013
            C PGF+   ++  C+D+DEC   P  C  G C N+PGSF C+CP G+  + +G  C D  
Sbjct: 577  CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVD 636

Query: 2014 QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG 2073
            +                          C++ PG      C+  P     +F+ +CP G  
Sbjct: 637  E--------------------------CTQSPGLCGRGACKNLP----GSFRCVCPAGFR 666

Query: 2074 AVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVG 2133
                     EDV+ECA+ P  C  G C NT GSF C CP G+     G  C D DEC+  
Sbjct: 667  G----SACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARS 722

Query: 2134 HP-CGQGTCTNVIGGFECACADGFEPGLMMT-CEDIDECSLNPLLCAFR-CHNTEGSYLC 2190
             P C  G C N  G F+C C  GF+P    + CED+DEC  N L C  + C N+ GS+ C
Sbjct: 723  PPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQC 781

Query: 2191 -TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249
             TCP+G+ L      C DVDEC+ G   C   G  C N  G+F C C PG R   G    
Sbjct: 782  RTCPSGHHLHR--GRCTDVDECSSGAPPCGPHG-HCTNTEGSFRCSCAPGYRAPSGRPGP 838

Query: 2250 CTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVL--Q 2306
            C D NEC  + D C  +G C+NT GSF C C  G++P P    C D+ +  C  E L   
Sbjct: 839  CADVNEC-LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE--CSEEDLCQS 895

Query: 2307 TMCRSLSSSSEAVTRAECCCGGGRGWGP----------------------RCELCPLPGT 2344
             +C +   S E      C C  G   GP                      RCE  P    
Sbjct: 896  GICTNTDGSFE------CICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSP---- 945

Query: 2345 SAYRKLCPHGSGYTA--EGR--DVDECRMLA-HLCAHGECINSLGSFRCH--CQAGYTPD 2397
             +YR +     GY A  EG   DVDEC+     +C    C N+ GS+RC   C  GY P 
Sbjct: 946  GSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQP- 1004

Query: 2398 ATATTCLDMDEC-SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN 2456
                 C D+DEC ++       +C+N  GSF C C +GY    DGR C D++EC + Q  
Sbjct: 1005 TPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGV 1064

Query: 2457 C-QFLCVNTVGAFTC--------------RCPPGFTQHHQACFDNDECSAQP-----GPC 2496
            C   LC N  G+F C              RC P  T          +  A P      P 
Sbjct: 1065 CGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1124

Query: 2497 GAHGHCHNTP-----GSFRCECHQGFTLVSSGHGCEDV-------NEC--------DGPH 2536
                   +TP     GS R EC+      ++   C+++        EC            
Sbjct: 1125 PPLPRRPSTPRQGPVGSGRRECYFD---TAAPDACDNILARNVTWQECCCTVGEGWGSGC 1181

Query: 2537 RCQHGCQNQLGGYRCSCPQG---FTQHSQWAQCVDENECAL-SPPTCGSASCRNTLGGFR 2592
            R Q     +   Y+  CP G          +   D +EC L     C S  C NT  G+ 
Sbjct: 1182 RIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYS 1241

Query: 2593 CVCPSGFDFDQALGGCQEVDECAGRRGPCSYS-CANTPGGFLCGC-PQGYFRAGQGHCVS 2650
            C C +G+ +      C + DECA     C    C NT G + C C P       Q  CVS
Sbjct: 1242 CYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS 1301



 Score =  374 bits (960), Expect = e-103
 Identities = 268/807 (33%), Positives = 329/807 (40%), Gaps = 156/807 (19%)

Query: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGF-------------VL 2002
            CP GF+  +  C D+DEC+     C  G C N+ G + C+CP GF             V+
Sbjct: 307  CPTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 365

Query: 2003 SDNGHRCFD---------------TRQSFCFTRFEAGK-----CSVPKAFNTTKTRCCCS 2042
            S+    CF                T+Q  C +R   GK     C +   F +   R  C 
Sbjct: 366  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSR--VGKAWGRGCQLCPPFGSEGFREICP 423

Query: 2043 KRPGEGWGD-------------------------PCELCPQEGSAAFQELCPFGHGAV-- 2075
              PG  +                           P    P  G      L P        
Sbjct: 424  AGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDP 483

Query: 2076 -PGPD---------------DSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDF 2119
             PGP+               +S      C  NP VC  G C++    + C C  G+ L  
Sbjct: 484  RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSP 543

Query: 2120 TGINCVDTDECS-VGHPCGQGTCTNVIGGFECACADGFEPGLMMT-CEDIDECSLNPLLC 2177
             G  C+D DEC  V  PC  G C N  G F C C  GF  G     C D+DEC   P  C
Sbjct: 544  QGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC 603

Query: 2178 AF-RCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVC 2236
               RC NT GS+LC CPAGY     GA C+DVDEC      C  RG  CKNL G+F CVC
Sbjct: 604  DLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLC-GRGA-CKNLPGSFRCVC 661

Query: 2237 PPGMR--------------PLP------------------------GSGEGCTDDNECHA 2258
            P G R              P P                        G G  C D +EC  
Sbjct: 662  PAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 721

Query: 2259 QPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ---------GPCFAEVLQTMC 2309
             P  C  GRC NT GSF+C C  GFQP+   +EC D+ +           C        C
Sbjct: 722  SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQC 781

Query: 2310 RSLSSSSEAVTRAEC-----CCGGGRGWGPRCELCPLPGTSAYRKLCPHG----SGYTAE 2360
            R+  S    + R  C     C  G    GP        G+  +R  C  G    SG    
Sbjct: 782  RTCPSGHH-LHRGRCTDVDECSSGAPPCGPHGHCTNTEGS--FRCSCAPGYRAPSGRPGP 838

Query: 2361 GRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLC 2420
              DV+EC        HGEC+N+ GSF C C  GY P     +CLD+DECS+     + +C
Sbjct: 839  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGIC 898

Query: 2421 KNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC--QFLCVNTVGAFTC--RCPPGF 2476
             NT GSF C CP G+    D  +C D+DEC  R         C N+ G++ C   C PG+
Sbjct: 899  TNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 958

Query: 2477 TQHHQ-ACFDNDECSAQ-PGPCGAHGHCHNTPGSFRC--ECHQGFTLVSSGHGCEDVNEC 2532
                +  C D DEC    P  CGA   C NTPGS+RC   C  G+   + G GC+DV+EC
Sbjct: 959  HAGPEGTCDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDEC 1016

Query: 2533 DGPHRC-QHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGG 2590
                 C  H  CQN  G ++C C QG+        CVD NEC      CG+A C N  G 
Sbjct: 1017 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1076

Query: 2591 FRCVCP-SGFDFDQALGGCQEVDECAG 2616
            F CVCP S  +FD   G C      AG
Sbjct: 1077 FLCVCPNSPEEFDPMTGRCVPPRTSAG 1103



 Score =  371 bits (953), Expect = e-102
 Identities = 326/1115 (29%), Positives = 438/1115 (39%), Gaps = 234/1115 (20%)

Query: 1297 CLNIPGSFSCRCLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA 1354
            C++ P  ++C C  G+     G  C D+DEC      C+P G C N PGS+RC C  GF 
Sbjct: 524  CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAP-GRCENSPGSFRCVCGPGFR 582

Query: 1355 GD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG- 1411
                   C D DEC      CD G+C N PG + C C  G+       +CQDVDEC Q  
Sbjct: 583  AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 642

Query: 1412 NLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECA-DPVNCINGVCINTPGSYLCS 1470
             LC  G+C+NLPG FRC+C  G+   RG     D++ECA +P  C  G C NT GS+ C+
Sbjct: 643  GLCGRGACKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCA 699

Query: 1471 CPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNP 1530
            CP  F     G  C D                   C+        R+   C+ GR     
Sbjct: 700  CPAGFRSRGPGAPCQDVD----------------ECA--------RSPPPCTYGR----- 730

Query: 1531 CELCPMANTT-EYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCE 1589
            CE     NT   ++ +CP   GFQPN      ED+DEC+     C G +CVN+ GSFQC 
Sbjct: 731  CE-----NTEGSFQCVCP--MGFQPNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCR 782

Query: 1590 -CPPGYHLSEHTRICEDIDECSTHSGICGP-GTCYNTLGNYTCVCPAEYLQVNGGNN-CM 1646
             CP G+HL  H   C D+DECS+ +  CGP G C NT G++ C C   Y   +G    C 
Sbjct: 783  TCPSGHHL--HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCA 840

Query: 1647 DMRKSV----CFRHYNGTCQN-ELAFNVTRKMCCCSYNIGQAWNRPC---------EACP 1692
            D+ + +    CF H  G C N + +F  T   C   Y  G      C         + C 
Sbjct: 841  DVNECLEGDFCFPH--GECLNTDGSFACT---CAPGYRPGPR-GASCLDVDECSEEDLCQ 894

Query: 1693 TPISPD----YQILCGNQAPGFLTDIHTGKPLDIDECGEI-PAICANGICINQIGSFRC- 1746
            + I  +    ++ +C    PG          LD+DEC E  PA+C +  C N  GS+RC 
Sbjct: 895  SGICTNTDGSFECIC---PPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCV 951

Query: 1747 -ECPAGFN---------------YNSILLA----------------------------CE 1762
             +C  G++               Y   +                              C+
Sbjct: 952  RDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ 1011

Query: 1763 DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDC 1821
            DVDEC +R S C  +A C N+PGS++C C +GY+ +  G  CV  NEC  +  VC    C
Sbjct: 1012 DVDECRNR-SFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALC 1070

Query: 1822 MDTEGSYMCLCHRG--------------------FQASADQTLCMDI-------DECDRQ 1854
             + EGS++C+C                       F  S  Q     +           R+
Sbjct: 1071 ENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR 1130

Query: 1855 PCGNGTCKNIIGSYNCLCFPGFVVTHNGDC-------VDFDECTTLVGQV----CRFGHC 1903
            P  +   +  +GS    C+  F       C       V + EC   VG+     CR   C
Sbjct: 1131 P--STPRQGPVGSGRRECY--FDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQC 1186

Query: 1904 LNT-AGSFHCLCQDGFELTADGKNCV---DTNEC-LSLAGTCLPGTCQNLEGSFRCICPP 1958
              T    +  LC  G    A   +     D +EC L     C  G C N    + C C  
Sbjct: 1187 PGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1246

Query: 1959 GF--QVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC------- 2009
            G+    Q   CID DEC++E   C  G C N+ GS+ C C P  VL  +  RC       
Sbjct: 1247 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQS 1306

Query: 2010 FDTRQSFCFTRFEAG-KCSVPKA-FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQEL 2067
             D     C+    A   CS P+     T T CCC    GE WG  C LCP + S  F+ L
Sbjct: 1307 LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEAL 1364

Query: 2068 C------------------PFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSF-R 2108
            C                  P+ +G   GP             P            G F R
Sbjct: 1365 CNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFAR 1424

Query: 2109 CECPFG---YSLDFTGINCVDTDECSVGHPCGQGTCTNVI-----------------GGF 2148
             E P+G   + +     +     E     P G GT                      G +
Sbjct: 1425 REAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSY 1484

Query: 2149 ECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDV 2208
              + A+ +E      C  +D C+        RC      + C C  GY L      C D+
Sbjct: 1485 AGSLAEPYEELEAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDI 1538

Query: 2209 DECADGQQDCH-ARGMECKNLIGTFACVCPPGMRP 2242
            +EC + +          C N  G+F C+C PG  P
Sbjct: 1539 NECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1573



 Score =  367 bits (943), Expect = e-101
 Identities = 300/982 (30%), Positives = 400/982 (40%), Gaps = 182/982 (18%)

Query: 945  AVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNEC-KVFPGLCTHGTCR 1003
            A + V  ++ P  +    AS    G G+  R+   G        EC    PGL T   C 
Sbjct: 228  APYTVLAQSAPREDGYSDAS----GFGYCFRELRGG--------ECASPLPGLRTQEVC- 274

Query: 1004 NTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGF 1063
                   C  AG             + +C++  +  G    V+ P      C  G+E   
Sbjct: 275  -------CRGAG---------LAWGVHDCQLCSERLGNSERVSAPDG---PCPTGFER-- 313

Query: 1064 MLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL 1123
             +  +C DVDECA     C+ G C NT G Y C CP G  L +  ++C  I +  +S+  
Sbjct: 314  -VNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISEA- 368

Query: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHC--INTEGSYR-CS 1180
               G C  V+    CS       T  +Q C      +    GC + C    +EG    C 
Sbjct: 369  --KGPCFRVLRDGGCSLPILRNIT--KQICCCSRVGKAWGRGCQL-CPPFGSEGFREICP 423

Query: 1181 CGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMAT---------- 1230
             G GY               +E PRV        +P   R     GF+ T          
Sbjct: 424  AGPGYHYSASDLRYNTRPLGQEPPRV-SLSQPRTLPATSRPSA--GFLPTHRLEPRPEPR 480

Query: 1231 PDMR-------------TCVDVDE-------CDLNPHICLHGDCENTKGSFVCHCQLGYM 1270
            PD R             T  ++ E       C  NP +C  G C +    + C C  G+ 
Sbjct: 481  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR 540

Query: 1271 VRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD--GFECHDLDECVSQ 1328
            +    T C DVDEC      C +   C N PGSF C C PG+       EC D+DEC   
Sbjct: 541  LSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC--- 596

Query: 1329 EHRCSP---RGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPG 1383
             HR  P    G C N PGS+ C C  G+  A  G  C+D DEC ++  LC  G C N PG
Sbjct: 597  -HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPG 655

Query: 1384 GYRCECEMGFDPTEDHRAC-QDVDECAQ-GNLCAFGSCENLPGMFRCICNGGYELDRGGG 1441
             +RC C  GF  +    AC +DVDECAQ    C  G C+N  G F C C  G+     G 
Sbjct: 656  SFRCVCPAGFRGS----ACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGA 711

Query: 1442 NCTDINECA-DPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1500
             C D++ECA  P  C  G C NT GS+ C CP  F+ N +G  C D           D  
Sbjct: 712  PCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDV----------DEC 761

Query: 1501 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1560
            ++ ++C                     G  C   P   + + RT CP G      R T  
Sbjct: 762  ENHLACP--------------------GQECVNSP--GSFQCRT-CPSGHHLHRGRCT-- 796

Query: 1561 LEDIDECQE-LPGLCQGGDCVNTFGSFQCECPPGYHL-SEHTRICEDIDECSTHSGICGP 1618
              D+DEC    P     G C NT GSF+C C PGY   S     C D++EC      C P
Sbjct: 797  --DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFP 853

Query: 1619 -GTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCS 1677
             G C NT G++ C C   Y     G +C+D+ +          CQ+ +  N      C  
Sbjct: 854  HGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC----SEEDLCQSGICTNTDGSFEC-- 907

Query: 1678 YNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEI-PAICANGI 1736
                         CP               PG          LD+DEC E  PA+C +  
Sbjct: 908  ------------ICP---------------PGHRAGPDLASCLDVDECRERGPALCGSQR 940

Query: 1737 CINQIGSFRC--ECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRC--KCT 1792
            C N  GS+RC  +C  G++       C+DVDEC            C N PGSYRC   C 
Sbjct: 941  CENSPGSYRCVRDCDPGYHAGP-EGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACD 999

Query: 1793 RGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECD 1852
             GY+ +PGG C   +ECR      +H  C +  GS+ CLC +G++ + D   C+D++EC+
Sbjct: 1000 PGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECE 1059

Query: 1853 --RQPCGNGTCKNIIGSYNCLC 1872
              +  CG   C+N+ GS+ C+C
Sbjct: 1060 TLQGVCGAALCENVEGSFLCVC 1081



 Score =  348 bits (894), Expect = 3e-95
 Identities = 306/999 (30%), Positives = 366/999 (36%), Gaps = 223/999 (22%)

Query: 184  TGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTG 243
            TGP   + GP     Q    VC    C   + R  G  C         C  GF  +    
Sbjct: 498  TGPEIPESGPSSGMCQRNPQVCGPGRC---ISRPSGYTCA--------CDSGFRLSPQGT 546

Query: 244  ACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303
             C DVDEC+ VP  C  G C N  GSF C C  G R           RA  C  V     
Sbjct: 547  RCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGP--------RAAECLDV----- 593

Query: 304  CAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGL 363
                      R    CD GRC                                PG F  +
Sbjct: 594  ------DECHRVPPPCDLGRC-----------------------------ENTPGSFLCV 618

Query: 364  LGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGR 423
               G              PHG+                     Q +D C     LC  G 
Sbjct: 619  CPAGYQAA----------PHGASC-------------------QDVDECTQSPGLCGRGA 649

Query: 424  CLPTPSSYRCECNVGYTQDVRGECIDVDECTSSP--CHHGDCVNIPGTYHCRCYPGFQAT 481
            C   P S+RC C  G+      E  DVDEC   P  C  G C N  G++HC C  GF++ 
Sbjct: 650  CKNLPGSFRCVCPAGFRGSACEE--DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSR 707

Query: 482  PTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMC 541
                 C DVDEC  S   C  GRC NTEGSFQCVC  GF+ +  G  C D +EC     C
Sbjct: 708  GPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLAC 767

Query: 542  VNGVCLNEDGSFSC-LCKPGFLLAPGGHYCMDIDECQT--PGICVNGHCTNTEGSFRCQC 598
                C+N  GSF C  C  G  L  G   C D+DEC +  P    +GHCTNTEGSFRC C
Sbjct: 768  PGQECVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 825

Query: 599  LGGLAV--GTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQ 656
              G     G  G  C D +        +E   C   FP         C N D  F   C 
Sbjct: 826  APGYRAPSGRPG-PCADVN------ECLEGDFC---FPHGE------CLNTDGSFA--CT 867

Query: 657  LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAG 716
              P        A C           D++EC+ + ++C +G+C N  GS+ C+C  G+ AG
Sbjct: 868  CAPGYRPGPRGASC----------LDVDECS-EEDLCQSGICTNTDGSFECICPPGHRAG 916

Query: 717  ASGKDCTDVDEC-ALNSLLCDNGWCQNSPGSYSC--SCPPGFHFWQDTEICKDVDECLS- 772
                 C DVDEC      LC +  C+NSPGSY C   C PG+H   +   C DVDEC   
Sbjct: 917  PDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE-GTCDDVDECQEY 975

Query: 773  SPCVSGV--CRNLAGSYTC--KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828
             P + G   C N  GSY C   C PG +  P G  C D         + E R   N    
Sbjct: 976  GPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQD---------VDECR---NRSFC 1022

Query: 829  SLRSECCATLGAAWGSPCERCEIDPACARGF-ARMTGVTCDDVNECESFPGVCPNGRCVN 887
               + C    G+              C +G+     G  C DVNECE+  GVC    C N
Sbjct: 1023 GAHAVCQNLPGS----------FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCEN 1072

Query: 888  TAGSFRCECPEG-LMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAV 946
              GSF C CP      D     CV  R               T PG            A 
Sbjct: 1073 VEGSFLCVCPNSPEEFDPMTGRCVPPRTS-----------AGTFPGSQPQ--------AP 1113

Query: 947  WGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTV 1006
                  A P P  L      PR     S      R  Y D       P  C +   RN  
Sbjct: 1114 ASPVLPARPPPPPLPRRPSTPRQGPVGS----GRRECYFDT----AAPDACDNILARNVT 1165

Query: 1007 GSFHCACAG-GFALDAQERNC----------------------------TDIDECRISPD 1037
                C   G G+    + + C                             D+DEC++  D
Sbjct: 1166 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRD 1225

Query: 1038 -LCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKC 1096
             +C  G CVNT   + C C  GY      ++ C+D DECA +   C GG C NT GSY C
Sbjct: 1226 QVCKSGVCVNTAPGYSCYCSNGYYYHTQRLE-CIDNDECADEEPACEGGRCVNTVGSYHC 1284

Query: 1097 QCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGA 1135
             C P   L      C   +  SL D L   G C   +GA
Sbjct: 1285 TCEPPLVLDGSQRRCVSNESQSLDDNL---GVCWQEVGA 1320



 Score =  344 bits (882), Expect = 8e-94
 Identities = 335/1112 (30%), Positives = 427/1112 (38%), Gaps = 183/1112 (16%)

Query: 150  ICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKAL 209
            +C   CHNGG C+ P+RC C   F G  C+         G   P      LT  V T  L
Sbjct: 115  LCPLICHNGGVCVKPDRCLCPPDFAGKFCQLH-----SSGARPPAPAVPGLTRSVYTMPL 169

Query: 210  CCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGS 269
                     G+   +     HP     +  +H      V+            +      +
Sbjct: 170  ANHR-DDEHGVASMVSVHVEHPQEASVV--VH-----QVERVSGPWEEADAEAVARAEAA 221

Query: 270  FHCRCPVGHRLSDSSAACEDYRAGA-----CFSVLFGGRCAGDLAGHYTRRQCCCDRGRC 324
                    + +   SA  ED  + A     CF  L GG CA  L G  T+  CC   G  
Sbjct: 222  ARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLA 281

Query: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG 384
            W                  QLC++RL                 S  +  P GP    P G
Sbjct: 282  WGVHDC-------------QLCSERLG---------------NSERVSAPDGPC---PTG 310

Query: 385  SDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQD-V 443
             +              G+    + +D C      C +G C  T   Y C C  G+  D  
Sbjct: 311  FERVN-----------GSC---EDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSS 355

Query: 444  RGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLG 503
            R  CI     + +    G C  +     C          T+Q C         G  C L 
Sbjct: 356  RSSCISQHVISEA---KGPCFRVLRDGGCSL--PILRNITKQICCCSRVGKAWGRGCQLC 410

Query: 504  RCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVN--GVCLNEDGSFSCLCKP-- 559
                +EG F+ +C AG    P            T  +      V L++  +     +P  
Sbjct: 411  PPFGSEG-FREICPAG----PGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSA 465

Query: 560  GFL----LAPGGHYCMDI---DECQTPGI-CVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
            GFL    L P      D     E   P I    G      G     C     V   GR C
Sbjct: 466  GFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR-C 524

Query: 612  VDTHVRSTCYGAIEKGSCARPFPGT--VTKSECCCANPDHGFGEPCQLCPAKDSAEFQAL 669
            +      TC  A + G    P  GT  +   EC    P    G  C+  P      F+ +
Sbjct: 525  ISRPSGYTC--ACDSGFRLSP-QGTRCIDVDECRRVPPPCAPGR-CENSP----GSFRCV 576

Query: 670  CSSGLGI---TTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVD 726
            C  G        +  D++EC   P  C  G CEN  GS+ CVC  GY+A   G  C DVD
Sbjct: 577  CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVD 636

Query: 727  ECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSS--PCVSGVCRNLA 784
            EC  +  LC  G C+N PGS+ C CP GF   + +   +DVDEC     PC  G C N A
Sbjct: 637  ECTQSPGLCGRGACKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRCDNTA 693

Query: 785  GSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGS 844
            GS+ C C  G R    G  C D                          EC  +       
Sbjct: 694  GSFHCACPAGFRSRGPGAPCQDV------------------------DECARSPPPCTYG 729

Query: 845  PCERCE--IDPACARGFARMT-GVTCDDVNECESFPGVCPNGRCVNTAGSFRCE-CPEGL 900
             CE  E      C  GF   T G  C+DV+ECE+    CP   CVN+ GSF+C  CP G 
Sbjct: 730  RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHL-ACPGQECVNSPGSFQCRTCPSGH 788

Query: 901  MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL 960
             L   GR C DV           DEC    P       C  + G+     C   P     
Sbjct: 789  HLH-RGR-CTDV-----------DECSSGAPPCGPHGHCTNTEGS---FRCSCAP----- 827

Query: 961  EFASLCPRGLGFASRDFLSGRPF-YKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFAL 1019
                      G+ +    SGRP    DVNEC        HG C NT GSF C CA G+  
Sbjct: 828  ----------GYRAP---SGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRP 874

Query: 1020 DAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDEC-ARD 1078
              +  +C D+DEC    DLC  G C NT GSFEC C PG+ +G  L  +C+DVDEC  R 
Sbjct: 875  GPRGASCLDVDECS-EEDLCQSGICTNTDGSFECICPPGHRAGPDL-ASCLDVDECRERG 932

Query: 1079 PLLCRGGTCTNTDGSYKC--QCPPGHELTAKGTACEDIDEC-SLSDGLCPHGQCVNVIGA 1135
            P LC    C N+ GSY+C   C PG+    +GT C+D+DEC      +C   +C N  G+
Sbjct: 933  PALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT-CDDVDECQEYGPEICGAQRCENTPGS 991

Query: 1136 FQC--SCHAGFQSTPDRQGCVDINECRVQNGGCDVH--CINTEGSYRCSCGQGYSLMPDG 1191
            ++C  +C  G+Q TP   GC D++ECR     C  H  C N  GS++C C QGY    DG
Sbjct: 992  YRCTPACDPGYQPTPG-GGCQDVDECR-NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDG 1049

Query: 1192 RACADVDECEENPRVCDQGHCTNMPGGHRCLC 1223
            R C DV+ECE    VC    C N+ G   C+C
Sbjct: 1050 RHCVDVNECETLQGVCGAALCENVEGSFLCVC 1081



 Score =  344 bits (882), Expect = 8e-94
 Identities = 272/913 (29%), Positives = 350/913 (38%), Gaps = 187/913 (20%)

Query: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLG 1626
            CQ  P +C  G C++    + C C  G+ LS     C D+DEC      C PG C N+ G
Sbjct: 512  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 571

Query: 1627 NYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNR 1686
            ++ CVC   +        C+D+ +  C R     C      N      C           
Sbjct: 572  SFRCVCGPGFRAGPRAAECLDVDE--CHR-VPPPCDLGRCENTPGSFLC----------- 617

Query: 1687 PCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRC 1746
                CP                G+    H     D+DEC + P +C  G C N  GSFRC
Sbjct: 618  ---VCPA---------------GYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 659

Query: 1747 ECPAGFNYNSILLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL-SPGGACV 1804
             CPAGF  +    ACE DVDEC     PC     C N  GS+ C C  G++   PG  C 
Sbjct: 660  VCPAGFRGS----ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQ 714

Query: 1805 GRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ-PCGNGTCKN 1863
              +EC   P  C++G C +TEGS+ C+C  GFQ +   + C D+DEC+    C    C N
Sbjct: 715  DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVN 774

Query: 1864 IIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTAD 1923
              GS+ C   P     H G C D DEC++        GHC NT GSF C C  G+   + 
Sbjct: 775  SPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 834

Query: 1924 GKN-CVDTNECLSLAGTCLP-GTCQNLEGSFRCICPPGFQV--QSDHCIDIDECSEEPNL 1979
                C D NECL     C P G C N +GSF C C PG++   +   C+D+DECSEE +L
Sbjct: 835  RPGPCADVNECLE-GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE-DL 892

Query: 1980 CLFGTCTNSPGSFQCLCPPGFVLSDN-------------------GHRCFDTRQSF---- 2016
            C  G CTN+ GSF+C+CPPG     +                     RC ++  S+    
Sbjct: 893  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 952

Query: 2017 -CFTRFEAGK-----------------CSVPKAFNTTKTRCCC-------SKRPGEGWGD 2051
             C   + AG                  C   +  NT  +  C           PG G  D
Sbjct: 953  DCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQD 1012

Query: 2052 PCE-----------LCPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNG 2098
              E           +C Q    +FQ LC  G+    G  D R   DVNEC    GVC   
Sbjct: 1013 VDECRNRSFCGAHAVC-QNLPGSFQCLCDQGY---EGARDGRHCVDVNECETLQGVCGAA 1068

Query: 2099 -----------VCVNTDGSF-----RCECPFGYSLDFTGIN-----------------CV 2125
                       VC N+   F     RC  P   +  F G                     
Sbjct: 1069 LCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLP 1128

Query: 2126 DTDECSVGHPCGQG------------TCTNVIGGF----ECACADGFEPGLMMTCEDIDE 2169
                     P G G             C N++       EC C  G   G          
Sbjct: 1129 RRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWG--------SG 1180

Query: 2170 CSLNPLLCAFRCHNTE-GSYLCTCPAG---YTLREDGAMCRDVDECADGQQDCHARGMEC 2225
            C +       +C  TE   Y   CP G        D ++ RDVDEC   +      G+ C
Sbjct: 1181 CRIQ------QCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV-C 1233

Query: 2226 KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD----- 2280
             N    ++C C  G        E C D++EC  +   C  GRCVNT GS+ C C+     
Sbjct: 1234 VNTAPGYSCYCSNGYYYHTQRLE-CIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1292

Query: 2281 EGFQPSPTLTECH--DIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL 2338
            +G Q      E    D   G C+ EV   +  S        T  ECCC  G  WG  C L
Sbjct: 1293 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1352

Query: 2339 CPLPGTSAYRKLC 2351
            CP   +  +  LC
Sbjct: 1353 CPAQDSDDFEALC 1365



 Score =  340 bits (873), Expect = 9e-93
 Identities = 195/490 (39%), Positives = 243/490 (49%), Gaps = 46/490 (9%)

Query: 2170 CSLNPLLCA-FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNL 2228
            C  NP +C   RC +    Y C C +G+ L   G  C DVDEC      C A G  C+N 
Sbjct: 512  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APG-RCENS 569

Query: 2229 IGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPT 2288
             G+F CVC PG R  P + E C D +ECH  P  C  GRC NT GSF C C  G+Q +P 
Sbjct: 570  PGSFRCVCGPGFRAGPRAAE-CLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPH 628

Query: 2289 LTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYR 2348
               C D+                     +  T++   CG G      C+   LPG+  +R
Sbjct: 629  GASCQDV---------------------DECTQSPGLCGRGA-----CK--NLPGS--FR 658

Query: 2349 KLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDE 2408
             +CP G   +A   DVDEC      C  G C N+ GSF C C AG+        C D+DE
Sbjct: 659  CVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 718

Query: 2409 CSQVPKPCTF-LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGA 2467
            C++ P PCT+  C+NT+GSF C CP G+     G  C+D+DEC +        CVN+ G+
Sbjct: 719  CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGS 778

Query: 2468 FTCR-CPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHG- 2525
            F CR CP G   H   C D DECS+   PCG HGHC NT GSFRC C  G+   S   G 
Sbjct: 779  FQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 838

Query: 2526 CEDVNEC-DGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSAS 2583
            C DVNEC +G     HG C N  G + C+C  G+    + A C+D +EC+     C S  
Sbjct: 839  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDLCQSGI 897

Query: 2584 CRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPC---SYSCANTPGGFLC--GCPQ 2638
            C NT G F C+CP G      L  C +VDEC   RGP    S  C N+PG + C   C  
Sbjct: 898  CTNTDGSFECICPPGHRAGPDLASCLDVDECR-ERGPALCGSQRCENSPGSYRCVRDCDP 956

Query: 2639 GYFRAGQGHC 2648
            GY    +G C
Sbjct: 957  GYHAGPEGTC 966



 Score =  291 bits (745), Expect = 6e-78
 Identities = 336/1223 (27%), Positives = 443/1223 (36%), Gaps = 283/1223 (23%)

Query: 33   WDGA-LEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCP---GWRTFPGRSQCV-VPICR 87
            W G  +  +GP     + +P +  GP  C SR   Y C    G+R  P  ++C+ V  CR
Sbjct: 497  WTGPEIPESGPSSGMCQRNPQVC-GPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECR 555

Query: 88   RA-------------------CGEGFCSQPNLCTCAD----GTLAPSCGVSRGSGCSVSC 124
            R                    CG GF + P    C D      + P C + R       C
Sbjct: 556  RVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR-------C 608

Query: 125  MNGGTCRGASCLCQKGYTGTVCGQP------------ICDRG-CHNGGRCIGPNRCACVY 171
             N  T     C+C  GY     G              +C RG C N     G  RC C  
Sbjct: 609  EN--TPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKN---LPGSFRCVCPA 663

Query: 172  GFMGPQCERDY-----RTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
            GF G  CE D         PC    GP  C +      C                   CP
Sbjct: 664  GFRGSACEEDVDECAQEPPPC----GPGRCDNTAGSFHCA------------------CP 701

Query: 227  AQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286
            A       GF        CQDVDEC   P  C  G C N  GSF C CP+G + + + + 
Sbjct: 702  A-------GFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE 754

Query: 287  CEDYR---------AGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPR 337
            CED              C +     +C    +GH+  R  C D   C +  P    C P 
Sbjct: 755  CEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPP---CGPH 811

Query: 338  G-----SNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS 392
            G        F+  CA      PG+                                  PS
Sbjct: 812  GHCTNTEGSFRCSCA------PGYRA--------------------------------PS 833

Query: 393  LGPGNSNIGTATLNQTIDICRHFTNLCL-NGRCLPTPSSYRCECNVGYTQDVRG-ECIDV 450
              PG      A +N+ ++      + C  +G CL T  S+ C C  GY    RG  C+DV
Sbjct: 834  GRPGPC----ADVNECLE-----GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDV 884

Query: 451  DECTSSP-CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSG-GLCHLGRCVNT 508
            DEC+    C  G C N  G++ C C PG +A P   +C+DVDEC   G  LC   RC N+
Sbjct: 885  DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENS 944

Query: 509  EGSFQCV--CNAGFELSPDGKNCVDHNECAT--STMCVNGVCLNEDGSFSCL--CKPGFL 562
             GS++CV  C+ G+   P+G  C D +EC      +C    C N  GS+ C   C PG+ 
Sbjct: 945  PGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ 1003

Query: 563  LAPGGHYCMDIDECQTPGIC-VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCY 621
              PGG  C D+DEC+    C  +  C N  GSF+C C  G     DGR CVD +   T  
Sbjct: 1004 PTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1062

Query: 622  GAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLC-PAKDSA------EFQALCSSGL 674
            G      C       +    C C N    F      C P + SA      + QA  S  L
Sbjct: 1063 GVCGAALCENVEGSFL----CVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVL 1118

Query: 675  ------------------GITTDGRDINECALD---PEVCANGVCENLRGSYRCVCNLG- 712
                              G    GR   EC  D   P+ C N +  N+     C C +G 
Sbjct: 1119 PARPPPPPLPRRPSTPRQGPVGSGR--RECYFDTAAPDACDNILARNVTWQ-ECCCTVGE 1175

Query: 713  -YEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL 771
             + +G   + C   +     SL C +G    +P               D  + +DVDEC 
Sbjct: 1176 GWGSGCRIQQCPGTETAEYQSL-CPHGRGYLAPSG-------------DLSLRRDVDECQ 1221

Query: 772  ---SSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828
                  C SGVC N A  Y+C C  G         C+D+ +       +E  CE      
Sbjct: 1222 LFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDE----CADEEPACE------ 1271

Query: 829  SLRSECCATLGAAWGSPCER-CEIDPACARGFARMTGVTCDDVNECESFPG---VCPNGR 884
                 C  T+G+ +   CE    +D +  R  +  +    D++  C    G   VC + R
Sbjct: 1272 --GGRCVNTVGS-YHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPR 1328

Query: 885  CVNTAGSFRCECPEGLMLDASGRLC-----------VDVRLEPCFLRWDEDECGVTLPGK 933
                A    C C  G        LC            +V   P +        G  LP +
Sbjct: 1329 LDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYS--PPRPGGFGLPYE 1386

Query: 934  YRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYK-------- 985
            Y  D+     G  +G E      P +L +    P    FA R+   G P +         
Sbjct: 1387 YGPDLGPPYQGLPYGPELYP---PPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDG 1443

Query: 986  ---DVNECKVFPGLCTHGT--CRNTVGSFH--------CACAGGFALDAQERNCTDIDEC 1032
                 +E    PG  T      R+T  SF          + AG  A   +E    + +EC
Sbjct: 1444 GPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEE---LEAEEC 1500

Query: 1033 RISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDEC----ARDPLLCRGGTCT 1088
             I  D C  G CV  P  F C CF GY      M  C+D++EC    A  PL C    C 
Sbjct: 1501 GIL-DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMA-CVDINECDEAEAASPL-CVNARCL 1557

Query: 1089 NTDGSYKCQCPPGHELTAKGTAC 1111
            NTDGS++C C PG   T +   C
Sbjct: 1558 NTDGSFRCICRPGFAPTHQPHHC 1580



 Score =  247 bits (630), Expect = 1e-64
 Identities = 176/548 (32%), Positives = 224/548 (40%), Gaps = 54/548 (9%)

Query: 2152 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC 2211
            C  GFE  +  +CED+DEC+         C NT G Y C CP G+ L    + C      
Sbjct: 307  CPTGFER-VNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 365

Query: 2212 ADGQQDCHA--RGMEC-----KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCV 2264
            ++ +  C    R   C     +N+     C    G       G GC           LC 
Sbjct: 366  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGK----AWGRGC----------QLCP 411

Query: 2265 NGRCVNTAGSFRCDCDEG----FQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEA-- 2318
                   +  FR  C  G    +  S        + Q P    + Q      +S   A  
Sbjct: 412  PFG----SEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 467

Query: 2319 --VTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAH 2376
                R E          P  EL PLP   A+      G      G     C+    +C  
Sbjct: 468  LPTHRLEPRPEPRPDPRPGPEL-PLPSIPAWT-----GPEIPESGPSSGMCQRNPQVCGP 521

Query: 2377 GECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCT-FLCKNTKGSFLCSCPRGY 2435
            G CI+    + C C +G+      T C+D+DEC +VP PC    C+N+ GSF C C  G+
Sbjct: 522  GRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGF 581

Query: 2436 LLEEDGRTCKDLDECTSRQHNCQF-LCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQ 2492
                    C D+DEC      C    C NT G+F C CP G+    H  +C D DEC+  
Sbjct: 582  RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQS 641

Query: 2493 PGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNEC-DGPHRCQHG-CQNQLGGY 2549
            PG CG  G C N PGSFRC C  GF     G  CE DV+EC   P  C  G C N  G +
Sbjct: 642  PGLCG-RGACKNLPGSFRCVCPAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSF 696

Query: 2550 RCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQ 2609
             C+CP GF      A C D +ECA SPP C    C NT G F+CVCP GF  + A   C+
Sbjct: 697  HCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE 756

Query: 2610 EVDECAGRRGPCSYSCANTPGGFLC-GCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELL 2668
            +VDEC          C N+PG F C  CP G+    +G C      S G           
Sbjct: 757  DVDECENHLACPGQECVNSPGSFQCRTCPSGH-HLHRGRCTDVDECSSGAPPCGPHGHCT 815

Query: 2669 SSEACYEC 2676
            ++E  + C
Sbjct: 816  NTEGSFRC 823



 Score =  238 bits (608), Expect = 5e-62
 Identities = 166/497 (33%), Positives = 215/497 (43%), Gaps = 72/497 (14%)

Query: 2198 LREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV------CPPGMRPLPGSGEGCT 2251
            LR     CR     A G  DC      C   +G    V      CP G   + GS   C 
Sbjct: 268  LRTQEVCCRGAG-LAWGVHDCQL----CSERLGNSERVSAPDGPCPTGFERVNGS---CE 319

Query: 2252 DDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC---HDIRQ--GPCFAEVLQ 2306
            D +EC A    C +G C NT G + C C +GF    + + C   H I +  GPCF  +  
Sbjct: 320  DVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRD 378

Query: 2307 TMCRSLSSSSEAVTRAECCCGG-GRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRD-- 2363
              C SL      +T+  CCC   G+ WG  C+LCP  G+  +R++CP G GY     D  
Sbjct: 379  GGC-SLPILRN-ITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLR 436

Query: 2364 --------------VDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
                          + + R L            L + R   +    PD      L +   
Sbjct: 437  YNTRPLGQEPPRVSLSQPRTLP--ATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSI 494

Query: 2410 -----SQVPK--PCTFLCK------------NTKGSFLCSCPRGYLLEEDGRTCKDLDEC 2450
                  ++P+  P + +C+            +    + C+C  G+ L   G  C D+DEC
Sbjct: 495  PAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDEC 554

Query: 2451 TSRQHNC-QFLCVNTVGAFTCRCPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPG 2507
                  C    C N+ G+F C C PGF    +A  C D DEC   P PC   G C NTPG
Sbjct: 555  RRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL-GRCENTPG 613

Query: 2508 SFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQ 2565
            SF C C  G+     G  C+DV+EC   P  C  G C+N  G +RC CP GF    + + 
Sbjct: 614  SFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSA 669

Query: 2566 C-VDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYS 2624
            C  D +ECA  PP CG   C NT G F C CP+GF        CQ+VDECA    PC+Y 
Sbjct: 670  CEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYG 729

Query: 2625 -CANTPGGFLCGCPQGY 2640
             C NT G F C CP G+
Sbjct: 730  RCENTEGSFQCVCPMGF 746



 Score =  137 bits (345), Expect = 1e-31
 Identities = 112/393 (28%), Positives = 147/393 (37%), Gaps = 57/393 (14%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR-CELCPLPGTSAYRKLCPHGSG 2356
            G CF E+    C S        T+  CC G G  WG   C+LC     ++ R   P G  
Sbjct: 250  GYCFRELRGGECASPLPGLR--TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPC 307

Query: 2357 YTAEGR------DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECS 2410
             T   R      DVDEC      C HGEC N+ G + C C  G+  D++ ++C+     S
Sbjct: 308  PTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVIS 366

Query: 2411 QVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTC 2470
            +   PC  + ++      CS P    + +    C  + +   R   CQ         F  
Sbjct: 367  EAKGPCFRVLRDGG----CSLPILRNITKQICCCSRVGKAWGR--GCQLCPPFGSEGFRE 420

Query: 2471 RCPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPGSFR------------------ 2510
             CP G   H+ A     N     Q  P  +       P + R                  
Sbjct: 421  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR 480

Query: 2511 -------------CECHQGFTLVSSGHG---CEDVNECDGPHRCQHGCQNQLGGYRCSCP 2554
                              G  +  SG     C+   +  GP R    C ++  GY C+C 
Sbjct: 481  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR----CISRPSGYTCACD 536

Query: 2555 QGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC 2614
             GF    Q  +C+D +EC   PP C    C N+ G FRCVC  GF        C +VDEC
Sbjct: 537  SGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC 596

Query: 2615 AGRRGPCSYS-CANTPGGFLCGCPQGYFRAGQG 2646
                 PC    C NTPG FLC CP GY  A  G
Sbjct: 597  HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 629



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 5/87 (5%)

Query: 1113 DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG----CDV 1168
            + +EC + DG C +G+CV V   F C C  G++    R  CVDINEC           + 
Sbjct: 1496 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 1169 HCINTEGSYRCSCGQGYSLMPDGRACA 1195
             C+NT+GS+RC C  G++       CA
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHCA 1581



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 35/88 (39%), Positives = 44/88 (50%), Gaps = 7/88 (7%)

Query: 1885 VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNEC---LSLAGTCL 1941
            ++ +EC  L G  C  G C+     F C C DG+ L      CVD NEC    + +  C+
Sbjct: 1495 LEAEECGILDG--CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1552

Query: 1942 PGTCQNLEGSFRCICPPGFQV--QSDHC 1967
               C N +GSFRCIC PGF    Q  HC
Sbjct: 1553 NARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 32/93 (34%), Positives = 42/93 (45%), Gaps = 4/93 (4%)

Query: 530  VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ----TPGICVNG 585
            ++  EC     C NG C+     F+C C  G+ L      C+DI+EC        +CVN 
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 586  HCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS 618
             C NT+GSFRC C  G A       C     R+
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1587



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 32/91 (35%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1928 VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPN---LCLF 1982
            ++  EC  L G C  G C  +   F C C  G+++      C+DI+EC E      LC+ 
Sbjct: 1495 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553

Query: 1983 GTCTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013
              C N+ GSF+C+C PGF  +   H C   R
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 56/220 (25%), Positives = 82/220 (37%), Gaps = 24/220 (10%)

Query: 8   LARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAY 67
           +AR   A    A +    +A    R DG  +A+G G   R    G    P + G R    
Sbjct: 215 VARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASP-LPGLRTQEV 273

Query: 68  CCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVS-CMN 126
           CC G     G   C      + C E   +   + +  DG          GS   V  C  
Sbjct: 274 CCRGAGLAWGVHDC------QLCSERLGNSERV-SAPDGPCPTGFERVNGSCEDVDECAT 326

Query: 127 GGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGP 186
           GG C+   C   +G    VC            G  +  +R +C+   +  + +     GP
Sbjct: 327 GGRCQHGECANTRGGYTCVCPD----------GFLLDSSRSSCISQHVISEAK-----GP 371

Query: 187 CFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
           CF  +   GC   +   +  +  CC+ VG+AWG  C+LCP
Sbjct: 372 CFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 411



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 5/99 (5%)

Query: 1141 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1200
            +AG  + P  +  ++  EC + +G  +  C+     + C C  GY L     AC D++EC
Sbjct: 1484 YAGSLAEPYEE--LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINEC 1541

Query: 1201 EENPR---VCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236
            +E      +C    C N  G  RC+C  GF  T     C
Sbjct: 1542 DEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 33/90 (36%), Positives = 40/90 (44%), Gaps = 13/90 (14%)

Query: 1318 ECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGD--GFFCEDRDECAENV---DL 1372
            EC  LD C +        G C+ VP  + C C  G+  D     C D +EC E      L
Sbjct: 1499 ECGILDGCTN--------GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL 1550

Query: 1373 CDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402
            C N +CLN  G +RC C  GF PT     C
Sbjct: 1551 CVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 36/95 (37%), Positives = 43/95 (45%), Gaps = 13/95 (13%)

Query: 2205 CRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNEC---HAQPD 2261
            C  +D C +G+         C  +   F C C  G R L  +   C D NEC    A   
Sbjct: 1500 CGILDGCTNGR---------CVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASP 1549

Query: 2262 LCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296
            LCVN RC+NT GSFRC C  GF P+     C   R
Sbjct: 1550 LCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 1082 CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDG---LCPHGQCVNVIGAFQC 1138
            C  G C      + C+C  G+ L     AC DI+EC  ++    LC + +C+N  G+F+C
Sbjct: 1506 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRC 1565

Query: 1139 SCHAGFQSTPDRQGC 1153
             C  GF  T     C
Sbjct: 1566 ICRPGFAPTHQPHHC 1580



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 31/94 (32%), Positives = 41/94 (43%), Gaps = 11/94 (11%)

Query: 2352 PHGSGYTA------EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLD 2405
            P G  Y        E  + +EC +L   C +G C+     F C C  GY  D T   C+D
Sbjct: 1479 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1537

Query: 2406 MDECSQV----PKPCTFLCKNTKGSFLCSCPRGY 2435
            ++EC +     P      C NT GSF C C  G+
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1571



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 1563 DIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDEC---STHSGICGPG 1619
            + +EC  L G C  G CV     F C C  GY L      C DI+EC      S +C   
Sbjct: 1496 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 1620 TCYNTLGNYTCVCPAEYLQVNGGNNCMDMR 1649
             C NT G++ C+C   +   +  ++C   R
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 35/114 (30%), Positives = 47/114 (41%), Gaps = 18/114 (15%)

Query: 1224 YDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
            Y G +A P     ++ +EC +    C +G C      F C C  GY +      C D++E
Sbjct: 1484 YAGSLAEPYEE--LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE 1540

Query: 1284 C---EVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSP 1334
            C   E     C  +A CLN  GSF C C PG+               Q H C+P
Sbjct: 1541 CDEAEAASPLC-VNARCLNTDGSFRCICRPGFAP-----------THQPHHCAP 1582



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 28/76 (36%), Positives = 35/76 (46%), Gaps = 4/76 (5%)

Query: 2528 DVNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENEC---ALSPPTCGSAS 2583
            +  EC     C +G C     G+ C C  G+        CVD NEC     + P C +A 
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555

Query: 2584 CRNTLGGFRCVCPSGF 2599
            C NT G FRC+C  GF
Sbjct: 1556 CLNTDGSFRCICRPGF 1571



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 29/85 (34%), Positives = 35/85 (41%), Gaps = 7/85 (8%)

Query: 2487 DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-----GPHRCQHG 2541
            +EC    G C  +G C   P  F C C  G+ L  +   C D+NECD      P      
Sbjct: 1498 EECGILDG-C-TNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555

Query: 2542 CQNQLGGYRCSCPQGFTQHSQWAQC 2566
            C N  G +RC C  GF    Q   C
Sbjct: 1556 CLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 26/82 (31%), Positives = 35/82 (42%), Gaps = 4/82 (4%)

Query: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL--- 2460
            L+ +EC  +       C      F C C  GY L+     C D++EC   +         
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 2461 -CVNTVGAFTCRCPPGFTQHHQ 2481
             C+NT G+F C C PGF   HQ
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQ 1576



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 31/90 (34%), Positives = 38/90 (42%), Gaps = 6/90 (6%)

Query: 830  LRSECCATLGAAWGSPCERCE--IDPACARGFAR-MTGVTCDDVNEC---ESFPGVCPNG 883
            L +E C  L       C R        C  G+   MT + C D+NEC   E+   +C N 
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
            RC+NT GSFRC C  G         C   R
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1584



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 8/101 (7%)

Query: 2554 PQGFTQHSQWAQCVDE---NECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQE 2610
            P+G +     A+  +E    EC +    C +  C     GF C C  G+  D     C +
Sbjct: 1479 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1537

Query: 2611 VDEC--AGRRGPCSYS--CANTPGGFLCGCPQGYFRAGQGH 2647
            ++EC  A    P   +  C NT G F C C  G+    Q H
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPH 1578



 Score = 40.4 bits (93), Expect = 0.025
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 3/61 (4%)

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPG---LCQGGDCVNTFGSFQCECPPGYHLSEHTRI 1602
            C   +G++ +   +   DI+EC E      LC    C+NT GSF+C C PG+  +     
Sbjct: 1520 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHH 1579

Query: 1603 C 1603
            C
Sbjct: 1580 C 1580



 Score = 38.9 bits (89), Expect = 0.072
 Identities = 14/34 (41%), Positives = 21/34 (61%)

Query: 2363 DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTP 2396
            + DE    + LC +  C+N+ GSFRC C+ G+ P
Sbjct: 1540 ECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1573



 Score = 37.4 bits (85), Expect = 0.21
 Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 11/94 (11%)

Query: 247  DVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDY----RAGACFSVLFGG 302
            + +EC  + G C  G CV +   F CRC  G+RL  +  AC D      A A   +    
Sbjct: 1496 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554

Query: 303  RCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPP 336
            RC  +  G +   +C C  G  +A    P  C P
Sbjct: 1555 RCL-NTDGSF---RCICRPG--FAPTHQPHHCAP 1582



 Score = 36.6 bits (83), Expect = 0.36
 Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 3/66 (4%)

Query: 232  CRRGFIPNIHTGACQDVDEC---QAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACE 288
            C  G+  ++   AC D++EC   +A   LC    C+N  GSF C C  G   +     C 
Sbjct: 1522 CFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCA 1581

Query: 289  DYRAGA 294
              R  A
Sbjct: 1582 PARPRA 1587



 Score = 36.2 bits (82), Expect = 0.47
 Identities = 15/37 (40%), Positives = 19/37 (51%)

Query: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
            D C NGRCV     F C C +G++   T   C DI +
Sbjct: 1504 DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE 1540


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  581 bits (1497), Expect = e-165
 Identities = 439/1396 (31%), Positives = 570/1396 (40%), Gaps = 207/1396 (14%)

Query: 620  CYGAIEKGSCARPFPGTVTKSECCCANPDHGFG-EPCQLCPAK--DSAEFQAL---CSSG 673
            C+  +  G CA P PG  T+ E CC      +G   CQLC  +  +S    A    C +G
Sbjct: 289  CFRELRGGECASPLPGLRTQ-EVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 347

Query: 674  LG-ITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNS 732
               +     D++ECA     C +G C N RG Y CVC  G+   +S   C  + +  ++ 
Sbjct: 348  FERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE 404

Query: 733  LLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGS---YTC 789
                 G C        CS P   +  +    C  V +     C   +C           C
Sbjct: 405  A---KGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQ--LCPPFGSEGFREIC 459

Query: 790  KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVN----LQGASLRSECCATLGAAWGSP 845
              GPG     S     D    T  L  +  R  ++    L   S  S            P
Sbjct: 460  PAGPGYHYSAS-----DLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRP 514

Query: 846  CERCEIDPACARGFARMTGVTCDDVNE-------CESFPGVCPNGRCVNTAGSFRCECPE 898
              R +  P        +   T  ++ E       C+  P VC  GRC++    + C C  
Sbjct: 515  EPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDS 574

Query: 899  GLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPE 958
            G  L   G  C+DV           DEC    P         C+ G      CE  P   
Sbjct: 575  GFRLSPQGTRCIDV-----------DECRRVPPP--------CAPG-----RCENSPG-- 608

Query: 959  SLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFA 1018
               F  +C  G     R          DV+EC   P  C  G C NT GSF C C  G+ 
Sbjct: 609  --SFRCVCGPGFRAGPR-----AAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQ 661

Query: 1019 LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARD 1078
                  +C D+DEC  SP LCG+G C N PGSF C C  G+           DVDECA++
Sbjct: 662  AAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE----DVDECAQE 717

Query: 1079 PLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQC 1138
            P  C  G C NT GS+ C CP G      G  C+D+DEC+ S   C +G+C N  G+FQC
Sbjct: 718  PPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQC 777

Query: 1139 SCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRC-SCGQGYSLMPDGRACADV 1197
             C  GFQ       C D++EC          C+N+ GS++C +C  G+ L   GR C DV
Sbjct: 778  VCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHR-GR-CTDV 835

Query: 1198 DECEENPRVCD-QGHCTNMPGGHRCLCYDGFMATPDMRT--CVDVDECDLNPHICL-HGD 1253
            DEC      C   GHCTN  G  RC C  G+ A P  R   C DV+EC L    C  HG+
Sbjct: 836  DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRA-PSGRPGPCADVNEC-LEGDFCFPHGE 893

Query: 1254 CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWV 1313
            C NT GSF C C  GY        C DVDEC      C S   C N  GSF C C PG  
Sbjct: 894  CLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDL-CQS-GICTNTDGSFECICPPGHR 951

Query: 1314 G--DGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCT--CRQGF-AGDGFFCEDRDECAE 1368
               D   C D+DEC  +         C N PGSYRC   C  G+ AG    C+D DEC E
Sbjct: 952  AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQE 1011

Query: 1369 -NVDLCDNGQCLNAPGGYRCE--CEMGFDPTEDHRACQDVDECAQGNLC-AFGSCENLPG 1424
               ++C   +C N PG YRC   C+ G+ PT     CQDVDEC   + C A   C+NLPG
Sbjct: 1012 YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPG 1070

Query: 1425 MFRCICNGGYELDRGGGNCTDINECADPVN-CINGVCINTPGSYLCSCPQD-FELNPSGV 1482
             F+C+C+ GYE  R G +C D+NEC      C   +C N  GS+LC CP    E +P   
Sbjct: 1071 SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG 1130

Query: 1483 GCVDTRAG-------------------------------------------NCFLETHDR 1499
             CV  R                                              C+ +T   
Sbjct: 1131 RCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTA-- 1188

Query: 1500 GDSGISCSAEIGVGVTRASCCCSLGRAWGNPCEL--CPMANTTEYRTLCPGGEGF-QPNR 1556
              +  +C   +   VT   CCC++G  WG+ C +  CP   T EY++LCP G G+  P+ 
Sbjct: 1189 --APDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSG 1246

Query: 1557 ITVILEDIDECQELPG-LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGI 1615
               +  D+DECQ     +C+ G CVNT   + C C  GY+       C D DEC+     
Sbjct: 1247 DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPA 1306

Query: 1616 CGPGTCYNTLGNYTCVCPAEYLQVNGGNNC-------MDMRKSVCFRHYNG--TCQN-EL 1665
            C  G C NT+G+Y C C    +       C       +D    VC++       C +  L
Sbjct: 1307 CEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRL 1366

Query: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAP---------GF------ 1710
                T   CCC Y  G+AW   C  CP   S D++ LC    P         GF      
Sbjct: 1367 DRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEY 1424

Query: 1711 ---LTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC 1767
               L   + G P    E    PA+  +          R E P G     +    +D    
Sbjct: 1425 GPDLGPPYQGLPYG-PELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPY 1483

Query: 1768 GSRESPCQQNADCINIPGS---YRCKCTRGYKLSP-----GGACVG----------RNEC 1809
            G  E+P          PG+   YR + TR     P     GG+  G            EC
Sbjct: 1484 GESEAPAPPG------PGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEEC 1537

Query: 1810 REIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP-----CGNGTCKNI 1864
              I + C++G C+     + C C  G++    +  C+DI+ECD        C N  C N 
Sbjct: 1538 -GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1596

Query: 1865 IGSYNCLCFPGFVVTH 1880
             GS+ C+C PGF  TH
Sbjct: 1597 DGSFRCICRPGFAPTH 1612



 Score =  538 bits (1386), Expect = e-152
 Identities = 356/1161 (30%), Positives = 481/1161 (41%), Gaps = 168/1161 (14%)

Query: 810  GTCWLKIQESRCEVNLQGASLRSECCATLGAAWG-SPCERCEI-----------DPACAR 857
            G C+ +++   C   L G   +  CC   G AWG   C+ C             D  C  
Sbjct: 287  GYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPT 346

Query: 858  GFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRL--- 914
            GF R+ G +C+DV+EC +  G C +G C NT G + C CP+G +LD+S   C+   +   
Sbjct: 347  GFERVNG-SCEDVDECAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISE 404

Query: 915  --EPCFLRWDEDECGVTLPGKYRMDVCCCS-IGAVWGVECEACPDPESLEFASLCPRGLG 971
               PCF    +  C + +       +CCCS +G  WG  C+ CP   S  F  +CP G G
Sbjct: 405  AKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPG 464

Query: 972  F---ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVG--------------------- 1007
            +   AS    + RP  ++     +        T R + G                     
Sbjct: 465  YHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGP 524

Query: 1008 SFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM- 1066
                     +       +      C+ +P +CG G C++ P  + C C    +SGF L  
Sbjct: 525  ELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCAC----DSGFRLSP 580

Query: 1067 --KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLC 1124
                C+DVDEC R P  C  G C N+ GS++C C PG     +   C D+DEC      C
Sbjct: 581  QGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC 640

Query: 1125 PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCD-VHCINTEGSYRCSCGQ 1183
              G+C N  G+F C C AG+Q+ P    C D++EC    G C    C N  GS+RC C  
Sbjct: 641  DLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPA 700

Query: 1184 GYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC 1242
            G+     G AC  DVDEC + P  C  G C N  G   C C  GF +      C DVDEC
Sbjct: 701  GFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC 756

Query: 1243 DLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPG 1302
              +P  C +G CENT+GSF C C +G+      + C DVDECE   H       C+N PG
Sbjct: 757  ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE--NHLACPGQECVNSPG 814

Query: 1303 SFSCR-CLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF---AGDGF 1358
            SF CR C  G       C D+DEC S    C P G C N  GS+RC+C  G+   +G   
Sbjct: 815  SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 874

Query: 1359 FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS 1418
             C D +EC E      +G+CLN  G + C C  G+ P     +C DVDEC++ +LC  G 
Sbjct: 875  PCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGI 934

Query: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECAD--PVNCINGVCINTPGSYLC--SCPQD 1474
            C N  G F CIC  G+       +C D++EC +  P  C +  C N+PGSY C   C   
Sbjct: 935  CTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPG 994

Query: 1475 FELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELC 1534
            +   P G              T D  D       EI          C   R     CE  
Sbjct: 995  YHAGPEG--------------TCDDVDECQEYGPEI----------CGAQR-----CENT 1025

Query: 1535 PMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGY 1594
            P      YR       G+QP       +D+DEC+          C N  GSFQC C  GY
Sbjct: 1026 P----GSYRCTPACDPGYQPTP-GGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGY 1080

Query: 1595 HLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVC---PAEYLQVNGGNNC------ 1645
              +   R C D++EC T  G+CG   C N  G++ CVC   P E+  + G   C      
Sbjct: 1081 EGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG--RCVPPRTS 1138

Query: 1646 -------------------------MDMRKSVCFRHYNGTCQNELAFNVTRKMCC----- 1675
                                     +  R S   +   G+ + E  F+      C     
Sbjct: 1139 AGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILA 1198

Query: 1676 -------CSYNIGQAWNRPC--EACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG 1726
                   C   +G+ W   C  + CP   + +YQ LC +               D+DEC 
Sbjct: 1199 RNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQ 1258

Query: 1727 EI-PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785
                 +C +G+C+N    + C C  G+ Y++  L C D DEC   E  C +   C+N  G
Sbjct: 1259 LFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCVNTVG 1317

Query: 1786 SYRCKCTRGYKLSPGGACVGRNECREIPN-------------VCSHGDCMDTEGSYM-CL 1831
            SY C C     L         NE + + +             VCSH   +D + +Y  C 
Sbjct: 1318 SYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH-PRLDRQATYTECC 1376

Query: 1832 CHRGFQASADQTLCMDIDECD 1852
            C  G     D  LC   D  D
Sbjct: 1377 CLYGEAWGMDCALCPAQDSDD 1397



 Score =  453 bits (1166), Expect = e-127
 Identities = 344/1156 (29%), Positives = 457/1156 (39%), Gaps = 260/1156 (22%)

Query: 1430 CNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
            C  G+E  R  G+C D++ECA    C +G C NT G Y C CP  F L+ S   C+    
Sbjct: 344  CPTGFE--RVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 401

Query: 1490 -----GNCFLETHDRGDSGISCSAEIGVGVTRASCCCS-LGRAWGNPC------------ 1531
                 G CF    D G     CS  I   +T+  CCCS +G+AWG  C            
Sbjct: 402  ISEAKGPCFRVLRDGG-----CSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFR 456

Query: 1532 ELCPM-------ANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFG 1584
            E+CP        A+   Y T   G E   P R++     + + + LP   +         
Sbjct: 457  EICPAGPGYHYSASDLRYNTRPLGQE---PPRVS-----LSQPRTLPATSRPSAGFLPTH 508

Query: 1585 SFQC------------ECP----PGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNY 1628
              +             E P    P +   E          C  +  +CGPG C +    Y
Sbjct: 509  RLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGY 568

Query: 1629 TCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPC 1688
            TC C + +     G  C+D+ +                                     C
Sbjct: 569  TCACDSGFRLSPQGTRCIDVDE-------------------------------------C 591

Query: 1689 EACPTPISP--------DYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ 1740
               P P +P         ++ +CG   PGF       + LD+DEC  +P  C  G C N 
Sbjct: 592  RRVPPPCAPGRCENSPGSFRCVCG---PGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 648

Query: 1741 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLS-- 1798
             GSF C CPAG+       +C+DVDEC      C + A C N+PGS+RC C  G++ S  
Sbjct: 649  PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSAC 707

Query: 1799 --------------------------------------PGGACVGRNECREIPNVCSHGD 1820
                                                  PG  C   +EC   P  C++G 
Sbjct: 708  EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 767

Query: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ-PCGNGTCKNIIGSYNCLCFPGFVVT 1879
            C +TEGS+ C+C  GFQ +   + C D+DEC+    C    C N  GS+ C   P     
Sbjct: 768  CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL 827

Query: 1880 HNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN-CVDTNECLSLAG 1938
            H G C D DEC++        GHC NT GSF C C  G+   +     C D NECL    
Sbjct: 828  HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLE-GD 886

Query: 1939 TCLP-GTCQNLEGSFRCICPPGFQ--VQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCL 1995
             C P G C N +GSF C C PG++   +   C+D+DECSEE +LC  G CTN+ GSF+C+
Sbjct: 887  FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE-DLCQSGICTNTDGSFECI 945

Query: 1996 CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCEL 2055
            CPPG     +   C D  +                         C  + P       CE 
Sbjct: 946  CPPGHRAGPDLASCLDVDE-------------------------CRERGPALCGSQRCEN 980

Query: 2056 CPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAE-NPGVCTNGVCVNTDGSFRC--ECP 2112
             P  GS      C  G+ A  GP+ + +DV+EC E  P +C    C NT GS+RC   C 
Sbjct: 981  SP--GSYRCVRDCDPGYHA--GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACD 1036

Query: 2113 FGYSLDFTGINCVDTDECSVGHPCG-QGTCTNVIGGFECACADGFEPGL-MMTCEDIDEC 2170
             GY     G  C D DEC     CG    C N+ G F+C C  G+E       C D++EC
Sbjct: 1037 PGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNEC 1095

Query: 2171 SLNPLLC-AFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
                 +C A  C N EGS+LC CP                   +       R +  +   
Sbjct: 1096 ETLQGVCGAALCENVEGSFLCVCP----------------NSPEEFDPMTGRCVPPRTSA 1139

Query: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
            GTF     PG +P            +  A P L                      P P  
Sbjct: 1140 GTF-----PGSQP------------QAPASPVLPARP-----------------PPPPLP 1165

Query: 2290 TECHDIRQGPC--------FAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL--C 2339
                  RQGP         F       C ++ + +  VT  ECCC  G GWG  C +  C
Sbjct: 1166 RRPSTPRQGPVGSGRRECYFDTAAPDACDNILARN--VTWQECCCTVGEGWGSGCRIQQC 1223

Query: 2340 PLPGTSAYRKLCPHGSGYTAEG------RDVDECRMLA-HLCAHGECINSLGSFRCHCQA 2392
            P   T+ Y+ LCPHG GY A        RDVDEC++    +C  G C+N+   + C+C  
Sbjct: 1224 PGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1283

Query: 2393 GYTPDATATTCLDMDECSQVPKPCT-FLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT 2451
            GY        C+D DEC+     C    C NT GS+ C+C    +L+   R C   +E  
Sbjct: 1284 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQ 1342

Query: 2452 SRQHNCQFLCVNTVGA 2467
            S   N   +C   VGA
Sbjct: 1343 SLDDNLG-VCWQEVGA 1357



 Score =  452 bits (1163), Expect = e-126
 Identities = 378/1156 (32%), Positives = 480/1156 (41%), Gaps = 220/1156 (19%)

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGL-PCELCP----------AQPHPCR 233
            G CF ++    C   L GL  T+ +CC   G AWG+  C+LC           A   PC 
Sbjct: 287  GYCFRELRGGECASPLPGLR-TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCP 345

Query: 234  RGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA- 292
             GF      G+C+DVDEC A  G CQ G C N  G + C CP G  L  S ++C      
Sbjct: 346  TGF--ERVNGSCEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 402

Query: 293  ----GACFSVLFGGRCAGDLAGHYTRRQCCCDR-GRCWAAGPVPELCPPRGSNEFQQLCA 347
                G CF VL  G C+  +  + T++ CCC R G+ W  G   +LCPP GS  F+++C 
Sbjct: 403  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRG--CQLCPPFGSEGFREIC- 459

Query: 348  QRLPLLPGH-------------------------PGLFPGL----LGFGSNGMGPPLGPA 378
               P  PG+                         P   P       GF       P    
Sbjct: 460  ---PAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEP 516

Query: 379  RLNPHGSDARGIPSL----GPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCE 434
            R +P       +PS+    GP     G ++      +C+    +C  GRC+  PS Y C 
Sbjct: 517  RPDPRPGPELPLPSIPAWTGPEIPESGPSS-----GMCQRNPQVCGPGRCISRPSGYTCA 571

Query: 435  CNVGYTQDVRG-ECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVD 491
            C+ G+    +G  CIDVDEC     PC  G C N PG++ C C PGF+A P    C+DVD
Sbjct: 572  CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVD 631

Query: 492  ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATST-MCVNGVCLNED 550
            EC      C LGRC NT GSF CVC AG++ +P G +C D +EC  S  +C  G C N  
Sbjct: 632  ECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLP 691

Query: 551  GSFSCLCKPGFLLAPGGHYC-MDIDEC-QTPGICVNGHCTNTEGSFRCQCLGGLAVGTDG 608
            GSF C+C  GF     G  C  D+DEC Q P  C  G C NT GSF C C  G      G
Sbjct: 692  GSFRCVCPAGF----RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPG 747

Query: 609  RVC--VDTHVRS---TCYGAIE--KGS----CARPFPGTVTKSEC----CCANPDHGFGE 653
              C  VD   RS     YG  E  +GS    C   F      SEC     C N     G+
Sbjct: 748  APCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQ 807

Query: 654  PCQLCPAKDSAEFQA-LCSSGLGITTDGR--DINECALDPEVCA-NGVCENLRGSYRCVC 709
             C   P      FQ   C SG  +   GR  D++EC+     C  +G C N  GS+RC C
Sbjct: 808  ECVNSP----GSFQCRTCPSGHHLHR-GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 862

Query: 710  NLGYEAGASGK--DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV 767
              GY A  SG+   C DV+EC        +G C N+ GS++C+C PG+        C DV
Sbjct: 863  APGYRA-PSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDV 921

Query: 768  DECLSSP-CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQ 826
            DEC     C SG+C N  GS+ C C PG R  P    CLD                    
Sbjct: 922  DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDV------------------- 962

Query: 827  GASLRSECCATLGAAWGSPCERCEIDPA-------CARGFARMTGVTCDDVNECESF-PG 878
                  EC     A  GS  +RCE  P        C  G+      TCDDV+EC+ + P 
Sbjct: 963  -----DECRERGPALCGS--QRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPE 1015

Query: 879  VCPNGRCVNTAGSFRC--ECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRM 936
            +C   RC NT GS+RC   C  G      G  C DV           DEC          
Sbjct: 1016 ICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQDV-----------DEC---------R 1054

Query: 937  DVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGL 996
            +   C   AV    C+  P      F  LC +G    +RD   GR    DVNEC+   G+
Sbjct: 1055 NRSFCGAHAV----CQNLPG----SFQCLCDQGYE-GARD---GR-HCVDVNECETLQGV 1101

Query: 997  CTHGTCRNTVGSFHCAC--------------------AGGFALDAQERNCTDIDECRISP 1036
            C    C N  GSF C C                    AG F     +   + +   R  P
Sbjct: 1102 CGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1161

Query: 1037 DLCGQGTCVNTP-----GSFECECFPGYES----GFMLMKN------CMDVDECARDPLL 1081
                +    +TP     GS   EC+    +      +L +N      C  V E       
Sbjct: 1162 PPLPRRP--STPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSG-- 1217

Query: 1082 CRGGTCTNTD-GSYKCQCPPGHELTAKG---TACEDIDECSL-SDGLCPHGQCVNVIGAF 1136
            CR   C  T+   Y+  CP G    A     +   D+DEC L  D +C  G CVN    +
Sbjct: 1218 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1277

Query: 1137 QCSCHAGFQSTPDRQGCVDINECRVQNGGCD-VHCINTEGSYRCSCGQGYSLMPDGRACA 1195
             C C  G+     R  C+D +EC  +   C+   C+NT GSY C+C     L    R C 
Sbjct: 1278 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1337

Query: 1196 --DVDECEENPRVCDQ 1209
              +    ++N  VC Q
Sbjct: 1338 SNESQSLDDNLGVCWQ 1353



 Score =  442 bits (1137), Expect = e-123
 Identities = 292/923 (31%), Positives = 399/923 (43%), Gaps = 164/923 (17%)

Query: 1366 CAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQ-GNLCAFGSCENLPG 1424
            C  N  +C  G+C++ P GY C C+ GF  +     C DVDEC +    CA G CEN PG
Sbjct: 549  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 608

Query: 1425 MFRCICNGGYELDRGGGNCTDINECAD-PVNCINGVCINTPGSYLCSCPQDFELNPSGVG 1483
             FRC+C  G+        C D++EC   P  C  G C NTPGS+LC CP  ++  P G  
Sbjct: 609  SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGAS 668

Query: 1484 CVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYR 1543
            C D                                C  S G      C+  P +    +R
Sbjct: 669  CQDVD-----------------------------ECTQSPGLCGRGACKNLPGS----FR 695

Query: 1544 TLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC 1603
             +CP G      R +   ED+DEC + P  C  G C NT GSF C CP G+        C
Sbjct: 696  CVCPAGF-----RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC 750

Query: 1604 EDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQN 1663
            +D+DEC+     C  G C NT G++ CVCP  +     G+ C D+ +          C+N
Sbjct: 751  QDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE----------CEN 800

Query: 1664 ELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDID 1723
             LA       C     +    +  C  CP+          G+        +H G+  D+D
Sbjct: 801  HLA-------CPGQECVNSPGSFQCRTCPS----------GHH-------LHRGRCTDVD 836

Query: 1724 ECGEIPAICA-NGICINQIGSFRCECPAGFNYNSILLA-CEDVDECGSRESPCQQNADCI 1781
            EC      C  +G C N  GSFRC C  G+   S     C DV+EC   +  C  + +C+
Sbjct: 837  ECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECL 895

Query: 1782 NIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASA 1840
            N  GS+ C C  GY+  P GA C+  +EC E  ++C  G C +T+GS+ C+C  G +A  
Sbjct: 896  NTDGSFACTCAPGYRPGPRGASCLDVDECSE-EDLCQSGICTNTDGSFECICPPGHRAGP 954

Query: 1841 DQTLCMDIDEC-DRQP--CGNGTCKNIIGSYNCL--CFPGFVVTHNGDCVDFDECTTLVG 1895
            D   C+D+DEC +R P  CG+  C+N  GSY C+  C PG+     G C D DEC     
Sbjct: 955  DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 1014

Query: 1896 QVCRFGHCLNTAGSFHCL--CQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFR 1953
            ++C    C NT GS+ C   C  G++ T  G  C D +EC + +       CQNL GSF+
Sbjct: 1015 EICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQ 1073

Query: 1954 CICPPGFQVQSD--HCIDIDECSEEPNLC-----------LFGTCTNSPGSF-----QCL 1995
            C+C  G++   D  HC+D++EC     +C               C NSP  F     +C+
Sbjct: 1074 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1133

Query: 1996 CPPGFVLSDNGHR-----------------------------CFDTRQSFCFTRFEAGKC 2026
             P     +  G +                                 R+   F       C
Sbjct: 1134 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1193

Query: 2027 SVPKAFNTTKTRCCCSKRPGEGWGDPCEL--CPQEGSAAFQELCPFGHG--AVPGPDDSR 2082
                A N T   CCC+   GEGWG  C +  CP   +A +Q LCP G G  A  G    R
Sbjct: 1194 DNILARNVTWQECCCTV--GEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLR 1251

Query: 2083 EDVNECAE-NPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP-CGQGT 2140
             DV+EC      VC +GVCVNT   + C C  GY      + C+D DEC+   P C  G 
Sbjct: 1252 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1311

Query: 2141 CTNVIGGFECACADGFEPGLMM-----TCEDIDECSLN------------PLLCAFRCHN 2183
            C N +G + C C    EP L++      C   +  SL+             L+C+    +
Sbjct: 1312 CVNTVGSYHCTC----EPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLD 1367

Query: 2184 TEGSYL-CTCPAGYTLREDGAMC 2205
             + +Y  C C  G     D A+C
Sbjct: 1368 RQATYTECCCLYGEAWGMDCALC 1390



 Score =  440 bits (1131), Expect = e-122
 Identities = 363/1186 (30%), Positives = 488/1186 (41%), Gaps = 203/1186 (17%)

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG-NPCELCPMANTTEYRTLCPG 1548
            G CF E       G  C++ +    T+  CC   G AWG + C+LC        R   P 
Sbjct: 287  GYCFRELR-----GGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPD 341

Query: 1549 GEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDE 1608
            G                                        CP G+     +  CED+DE
Sbjct: 342  GP---------------------------------------CPTGFERVNGS--CEDVDE 360

Query: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMR-----KSVCFRHY-NGTCQ 1662
            C+T  G C  G C NT G YTCVCP  +L  +  ++C+        K  CFR   +G C 
Sbjct: 361  CAT-GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCS 419

Query: 1663 NELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGF---LTDI-HTGK 1718
              +  N+T+++CCCS  +G+AW R C+ CP   S  ++ +C    PG+    +D+ +  +
Sbjct: 420  LPILRNITKQICCCS-RVGKAWGRGCQLCPPFGSEGFREICP-AGPGYHYSASDLRYNTR 477

Query: 1719 PLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNA 1778
            PL     G+ P      + ++Q  +     PA    ++  L    + E      P  +  
Sbjct: 478  PL-----GQEPP----RVSLSQPRTL----PATSRPSAGFLPTHRL-EPRPEPRPDPRPG 523

Query: 1779 DCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA 1838
              + +P         G ++   G   G   C+  P VC  G C+     Y C C  GF+ 
Sbjct: 524  PELPLPS---IPAWTGPEIPESGPSSGM--CQRNPQVCGPGRCISRPSGYTCACDSGFRL 578

Query: 1839 SADQTLCMDIDECDR--QPCGNGTCKNIIGSYNCLCFPGFVV-THNGDCVDFDECTTLVG 1895
            S   T C+D+DEC R   PC  G C+N  GS+ C+C PGF       +C+D DEC   V 
Sbjct: 579  SPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHR-VP 637

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI 1955
              C  G C NT GSF C+C  G++    G +C D +EC    G C  G C+NL GSFRC+
Sbjct: 638  PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 697

Query: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
            CP GF+  +    D+DEC++EP  C  G C N+ GSF C CP GF     G  C D  + 
Sbjct: 698  CPAGFRGSACE-EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE- 755

Query: 2016 FCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV 2075
                                     C++ P       CE    EGS  FQ +CP G    
Sbjct: 756  -------------------------CARSPPPCTYGRCE--NTEGS--FQCVCPMGFQPN 786

Query: 2076 PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCE-CPFGYSLDFTGINCVDTDECSVGH 2134
                +  EDV+EC EN   C    CVN+ GSF+C  CP G+ L      C D DECS G 
Sbjct: 787  TAGSEC-EDVDEC-ENHLACPGQECVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGA 842

Query: 2135 P-CG-QGTCTNVIGGFECACADGFEP--GLMMTCEDIDECSLNPLLCAF-RCHNTEGSYL 2189
            P CG  G CTN  G F C+CA G+    G    C D++EC           C NT+GS+ 
Sbjct: 843  PPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFA 902

Query: 2190 CTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249
            CTC  GY     GA C DVDEC++  +D    G+ C N  G+F C+CPPG R  P     
Sbjct: 903  CTCAPGYRPGPRGASCLDVDECSE--EDLCQSGI-CTNTDGSFECICPPGHRAGPDLAS- 958

Query: 2250 CTDDNECHAQ-PDLCVNGRCVNTAGSFRC--DCDEGFQPSPTLT-----ECHDIRQGPCF 2301
            C D +EC  + P LC + RC N+ GS+RC  DCD G+   P  T     EC +     C 
Sbjct: 959  CLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICG 1018

Query: 2302 AEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCE---------LCP-LPGTSAYRKLC 2351
            A+  +    S   +       +   GGG      C          +C  LPG+  ++ LC
Sbjct: 1019 AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGS--FQCLC 1076

Query: 2352 PHGSGYTAEGR---DVDECRML-----AHLCAHGE------CINSLGSF-----RC---H 2389
              G     +GR   DV+EC  L     A LC + E      C NS   F     RC    
Sbjct: 1077 DQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPR 1136

Query: 2390 CQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDE 2449
              AG  P +           ++ P P                PR       G       E
Sbjct: 1137 TSAGTFPGSQPQAPASPVLPARPPPP--------------PLPRRPSTPRQGPVGSGRRE 1182

Query: 2450 C---TSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTP 2506
            C   T+    C  +    V    C C  G             C  Q  P        +  
Sbjct: 1183 CYFDTAAPDACDNILARNVTWQECCCTVGEGW-------GSGCRIQQCPGTETAEYQSL- 1234

Query: 2507 GSFRCECHQGFTLVSSGHGCE-DVNECD--GPHRCQHG-CQNQLGGYRCSCPQGFTQHSQ 2562
                C   +G+   S       DV+EC       C+ G C N   GY C C  G+  H+Q
Sbjct: 1235 ----CPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1290

Query: 2563 WAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
              +C+D +ECA   P C    C NT+G + C C      D +   C
Sbjct: 1291 RLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC 1336



 Score =  407 bits (1046), Expect = e-113
 Identities = 296/890 (33%), Positives = 387/890 (43%), Gaps = 112/890 (12%)

Query: 1763 DVDECGSRESPCQQNAD------CINIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNV 1815
            ++ E G     CQ+N        CI+ P  Y C C  G++LSP G  C+  +ECR +P  
Sbjct: 538  EIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPP 597

Query: 1816 CSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDR--QPCGNGTCKNIIGSYNCLCF 1873
            C+ G C ++ GS+ C+C  GF+A      C+D+DEC R   PC  G C+N  GS+ C+C 
Sbjct: 598  CAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCP 657

Query: 1874 PGF-VVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV-DTN 1931
             G+    H   C D DECT   G +C  G C N  GSF C+C  GF     G  C  D +
Sbjct: 658  AGYQAAPHGASCQDVDECTQSPG-LCGRGACKNLPGSFRCVCPAGFR----GSACEEDVD 712

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSP 1989
            EC      C PG C N  GSF C CP GF+ +     C D+DEC+  P  C +G C N+ 
Sbjct: 713  ECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTE 772

Query: 1990 GSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKC----------SVPKAFNTTKTRC 2039
            GSFQC+CP GF  +  G  C D  +          +C          + P   +  + RC
Sbjct: 773  GSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC 832

Query: 2040 -----CCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGV 2094
                 C S  P  G    C     EGS  F+  C  G+ A  G      DVNEC E    
Sbjct: 833  TDVDECSSGAPPCGPHGHCT--NTEGS--FRCSCAPGYRAPSGRPGPCADVNECLEGDFC 888

Query: 2095 CTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACAD 2154
              +G C+NTDGSF C C  GY     G +C+D DECS    C  G CTN  G FEC C  
Sbjct: 889  FPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPP 948

Query: 2155 GFEPGL-MMTCEDIDEC-SLNPLLCAF-RCHNTEGSYLCT--CPAGYTLREDGAMCRDVD 2209
            G   G  + +C D+DEC    P LC   RC N+ GSY C   C  GY    +G  C DVD
Sbjct: 949  GHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGT-CDDVD 1007

Query: 2210 ECAD-GQQDCHARGMECKNLIGTFACV--CPPGMRPLPGSGEGCTDDNECHAQPDLCVNG 2266
            EC + G + C A+   C+N  G++ C   C PG +P PG G  C D +EC  +     + 
Sbjct: 1008 ECQEYGPEICGAQ--RCENTPGSYRCTPACDPGYQPTPGGG--CQDVDECRNRSFCGAHA 1063

Query: 2267 RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCC 2326
             C N  GSF+C CD+G++ +     C D+ +     E LQ +C +    +   +    C 
Sbjct: 1064 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCVCP 1119

Query: 2327 GGGRGWGPRCELCPLPGTSAY-------------------------RKLCPHGSGYTAEG 2361
                 + P    C  P TSA                          R+      G    G
Sbjct: 1120 NSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSG 1179

Query: 2362 RDVDECRMLAHLCAHGECINSLGSF----RCHCQAGYTPDATATTCLDMDECSQVPKPCT 2417
            R   EC       A   C N L        C C  G   +   + C  + +C     P T
Sbjct: 1180 RR--ECYF--DTAAPDACDNILARNVTWQECCCTVG---EGWGSGCR-IQQC-----PGT 1226

Query: 2418 FLCKNTKGSFLCSCPRGYLLEE-DGRTCKDLDECTS-RQHNCQF-LCVNTVGAFTCRCPP 2474
               +  +   LC   RGYL    D    +D+DEC   R   C+  +CVNT   ++C C  
Sbjct: 1227 ---ETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1283

Query: 2475 GFTQHHQ--ACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC 2532
            G+  H Q   C DNDEC+ +   C   G C NT GS+ C C     L  S   C   NE 
Sbjct: 1284 GYYYHTQRLECIDNDECADEEPACEG-GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NES 1341

Query: 2533 DGPHRCQHGCQNQLGG-YRCSCPQGFTQHSQWAQCVDENE-----CALSP 2576
                     C  ++G    CS P+   Q +    C    E     CAL P
Sbjct: 1342 QSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCP 1391



 Score =  382 bits (981), Expect = e-105
 Identities = 275/840 (32%), Positives = 359/840 (42%), Gaps = 140/840 (16%)

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI 1955
            QVC  G C++    + C C  GF L+  G  C+D +EC  +   C PG C+N  GSFRC+
Sbjct: 554  QVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCV 613

Query: 1956 CPPGFQV--QSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013
            C PGF+   ++  C+D+DEC   P  C  G C N+PGSF C+CP G+  + +G  C D  
Sbjct: 614  CGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVD 673

Query: 2014 QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG 2073
            +                          C++ PG      C+  P     +F+ +CP G  
Sbjct: 674  E--------------------------CTQSPGLCGRGACKNLP----GSFRCVCPAGFR 703

Query: 2074 AVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVG 2133
                     EDV+ECA+ P  C  G C NT GSF C CP G+     G  C D DEC+  
Sbjct: 704  G----SACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARS 759

Query: 2134 HP-CGQGTCTNVIGGFECACADGFEPGLMMT-CEDIDECSLNPLLCAFR-CHNTEGSYLC 2190
             P C  G C N  G F+C C  GF+P    + CED+DEC  N L C  + C N+ GS+ C
Sbjct: 760  PPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECE-NHLACPGQECVNSPGSFQC 818

Query: 2191 -TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249
             TCP+G+ L      C DVDEC+ G   C   G  C N  G+F C C PG R   G    
Sbjct: 819  RTCPSGHHLHR--GRCTDVDECSSGAPPCGPHG-HCTNTEGSFRCSCAPGYRAPSGRPGP 875

Query: 2250 CTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVL--Q 2306
            C D NEC  + D C  +G C+NT GSF C C  G++P P    C D+ +  C  E L   
Sbjct: 876  CADVNEC-LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE--CSEEDLCQS 932

Query: 2307 TMCRSLSSSSEAVTRAECCCGGGRGWGP----------------------RCELCPLPGT 2344
             +C +   S E      C C  G   GP                      RCE  P    
Sbjct: 933  GICTNTDGSFE------CICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSP---- 982

Query: 2345 SAYRKLCPHGSGYTA--EGR--DVDECRMLA-HLCAHGECINSLGSFRCH--CQAGYTPD 2397
             +YR +     GY A  EG   DVDEC+     +C    C N+ GS+RC   C  GY P 
Sbjct: 983  GSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQP- 1041

Query: 2398 ATATTCLDMDEC-SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN 2456
                 C D+DEC ++       +C+N  GSF C C +GY    DGR C D++EC + Q  
Sbjct: 1042 TPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGV 1101

Query: 2457 C-QFLCVNTVGAFTC--------------RCPPGFTQHHQACFDNDECSAQP-----GPC 2496
            C   LC N  G+F C              RC P  T          +  A P      P 
Sbjct: 1102 CGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPP 1161

Query: 2497 GAHGHCHNTP-----GSFRCECHQGFTLVSSGHGCEDV-------NEC--------DGPH 2536
                   +TP     GS R EC+      ++   C+++        EC            
Sbjct: 1162 PPLPRRPSTPRQGPVGSGRRECYFD---TAAPDACDNILARNVTWQECCCTVGEGWGSGC 1218

Query: 2537 RCQHGCQNQLGGYRCSCPQG---FTQHSQWAQCVDENECAL-SPPTCGSASCRNTLGGFR 2592
            R Q     +   Y+  CP G          +   D +EC L     C S  C NT  G+ 
Sbjct: 1219 RIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYS 1278

Query: 2593 CVCPSGFDFDQALGGCQEVDECAGRRGPCSYS-CANTPGGFLCGC-PQGYFRAGQGHCVS 2650
            C C +G+ +      C + DECA     C    C NT G + C C P       Q  CVS
Sbjct: 1279 CYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVS 1338



 Score =  374 bits (960), Expect = e-103
 Identities = 268/807 (33%), Positives = 329/807 (40%), Gaps = 156/807 (19%)

Query: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGF-------------VL 2002
            CP GF+  +  C D+DEC+     C  G C N+ G + C+CP GF             V+
Sbjct: 344  CPTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 402

Query: 2003 SDNGHRCFD---------------TRQSFCFTRFEAGK-----CSVPKAFNTTKTRCCCS 2042
            S+    CF                T+Q  C +R   GK     C +   F +   R  C 
Sbjct: 403  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSR--VGKAWGRGCQLCPPFGSEGFREICP 460

Query: 2043 KRPGEGWGD-------------------------PCELCPQEGSAAFQELCPFGHGAV-- 2075
              PG  +                           P    P  G      L P        
Sbjct: 461  AGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDP 520

Query: 2076 -PGPD---------------DSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDF 2119
             PGP+               +S      C  NP VC  G C++    + C C  G+ L  
Sbjct: 521  RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSP 580

Query: 2120 TGINCVDTDECS-VGHPCGQGTCTNVIGGFECACADGFEPGLMMT-CEDIDECSLNPLLC 2177
             G  C+D DEC  V  PC  G C N  G F C C  GF  G     C D+DEC   P  C
Sbjct: 581  QGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC 640

Query: 2178 AF-RCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVC 2236
               RC NT GS+LC CPAGY     GA C+DVDEC      C  RG  CKNL G+F CVC
Sbjct: 641  DLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLC-GRGA-CKNLPGSFRCVC 698

Query: 2237 PPGMR--------------PLP------------------------GSGEGCTDDNECHA 2258
            P G R              P P                        G G  C D +EC  
Sbjct: 699  PAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 758

Query: 2259 QPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ---------GPCFAEVLQTMC 2309
             P  C  GRC NT GSF+C C  GFQP+   +EC D+ +           C        C
Sbjct: 759  SPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQC 818

Query: 2310 RSLSSSSEAVTRAEC-----CCGGGRGWGPRCELCPLPGTSAYRKLCPHG----SGYTAE 2360
            R+  S    + R  C     C  G    GP        G+  +R  C  G    SG    
Sbjct: 819  RTCPSGHH-LHRGRCTDVDECSSGAPPCGPHGHCTNTEGS--FRCSCAPGYRAPSGRPGP 875

Query: 2361 GRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLC 2420
              DV+EC        HGEC+N+ GSF C C  GY P     +CLD+DECS+     + +C
Sbjct: 876  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGIC 935

Query: 2421 KNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC--QFLCVNTVGAFTC--RCPPGF 2476
             NT GSF C CP G+    D  +C D+DEC  R         C N+ G++ C   C PG+
Sbjct: 936  TNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 995

Query: 2477 TQHHQ-ACFDNDECSAQ-PGPCGAHGHCHNTPGSFRC--ECHQGFTLVSSGHGCEDVNEC 2532
                +  C D DEC    P  CGA   C NTPGS+RC   C  G+   + G GC+DV+EC
Sbjct: 996  HAGPEGTCDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDEC 1053

Query: 2533 DGPHRC-QHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGG 2590
                 C  H  CQN  G ++C C QG+        CVD NEC      CG+A C N  G 
Sbjct: 1054 RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGS 1113

Query: 2591 FRCVCP-SGFDFDQALGGCQEVDECAG 2616
            F CVCP S  +FD   G C      AG
Sbjct: 1114 FLCVCPNSPEEFDPMTGRCVPPRTSAG 1140



 Score =  371 bits (953), Expect = e-102
 Identities = 326/1115 (29%), Positives = 438/1115 (39%), Gaps = 234/1115 (20%)

Query: 1297 CLNIPGSFSCRCLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA 1354
            C++ P  ++C C  G+     G  C D+DEC      C+P G C N PGS+RC C  GF 
Sbjct: 561  CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAP-GRCENSPGSFRCVCGPGFR 619

Query: 1355 GD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG- 1411
                   C D DEC      CD G+C N PG + C C  G+       +CQDVDEC Q  
Sbjct: 620  AGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 679

Query: 1412 NLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECA-DPVNCINGVCINTPGSYLCS 1470
             LC  G+C+NLPG FRC+C  G+   RG     D++ECA +P  C  G C NT GS+ C+
Sbjct: 680  GLCGRGACKNLPGSFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCA 736

Query: 1471 CPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNP 1530
            CP  F     G  C D                   C+        R+   C+ GR     
Sbjct: 737  CPAGFRSRGPGAPCQDVD----------------ECA--------RSPPPCTYGR----- 767

Query: 1531 CELCPMANTT-EYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCE 1589
            CE     NT   ++ +CP   GFQPN      ED+DEC+     C G +CVN+ GSFQC 
Sbjct: 768  CE-----NTEGSFQCVCP--MGFQPNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCR 819

Query: 1590 -CPPGYHLSEHTRICEDIDECSTHSGICGP-GTCYNTLGNYTCVCPAEYLQVNGGNN-CM 1646
             CP G+HL  H   C D+DECS+ +  CGP G C NT G++ C C   Y   +G    C 
Sbjct: 820  TCPSGHHL--HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCA 877

Query: 1647 DMRKSV----CFRHYNGTCQN-ELAFNVTRKMCCCSYNIGQAWNRPC---------EACP 1692
            D+ + +    CF H  G C N + +F  T   C   Y  G      C         + C 
Sbjct: 878  DVNECLEGDFCFPH--GECLNTDGSFACT---CAPGYRPGPR-GASCLDVDECSEEDLCQ 931

Query: 1693 TPISPD----YQILCGNQAPGFLTDIHTGKPLDIDECGEI-PAICANGICINQIGSFRC- 1746
            + I  +    ++ +C    PG          LD+DEC E  PA+C +  C N  GS+RC 
Sbjct: 932  SGICTNTDGSFECIC---PPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCV 988

Query: 1747 -ECPAGFN---------------YNSILLA----------------------------CE 1762
             +C  G++               Y   +                              C+
Sbjct: 989  RDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ 1048

Query: 1763 DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDC 1821
            DVDEC +R S C  +A C N+PGS++C C +GY+ +  G  CV  NEC  +  VC    C
Sbjct: 1049 DVDECRNR-SFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALC 1107

Query: 1822 MDTEGSYMCLCHRG--------------------FQASADQTLCMDI-------DECDRQ 1854
             + EGS++C+C                       F  S  Q     +           R+
Sbjct: 1108 ENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR 1167

Query: 1855 PCGNGTCKNIIGSYNCLCFPGFVVTHNGDC-------VDFDECTTLVGQV----CRFGHC 1903
            P  +   +  +GS    C+  F       C       V + EC   VG+     CR   C
Sbjct: 1168 P--STPRQGPVGSGRRECY--FDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQC 1223

Query: 1904 LNT-AGSFHCLCQDGFELTADGKNCV---DTNEC-LSLAGTCLPGTCQNLEGSFRCICPP 1958
              T    +  LC  G    A   +     D +EC L     C  G C N    + C C  
Sbjct: 1224 PGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1283

Query: 1959 GF--QVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC------- 2009
            G+    Q   CID DEC++E   C  G C N+ GS+ C C P  VL  +  RC       
Sbjct: 1284 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQS 1343

Query: 2010 FDTRQSFCFTRFEAG-KCSVPKA-FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQEL 2067
             D     C+    A   CS P+     T T CCC    GE WG  C LCP + S  F+ L
Sbjct: 1344 LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLY--GEAWGMDCALCPAQDSDDFEAL 1401

Query: 2068 C------------------PFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSF-R 2108
            C                  P+ +G   GP             P            G F R
Sbjct: 1402 CNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFAR 1461

Query: 2109 CECPFG---YSLDFTGINCVDTDECSVGHPCGQGTCTNVI-----------------GGF 2148
             E P+G   + +     +     E     P G GT                      G +
Sbjct: 1462 REAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSY 1521

Query: 2149 ECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDV 2208
              + A+ +E      C  +D C+        RC      + C C  GY L      C D+
Sbjct: 1522 AGSLAEPYEELEAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDI 1575

Query: 2209 DECADGQQDCH-ARGMECKNLIGTFACVCPPGMRP 2242
            +EC + +          C N  G+F C+C PG  P
Sbjct: 1576 NECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1610



 Score =  367 bits (943), Expect = e-101
 Identities = 300/982 (30%), Positives = 400/982 (40%), Gaps = 182/982 (18%)

Query: 945  AVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNEC-KVFPGLCTHGTCR 1003
            A + V  ++ P  +    AS    G G+  R+   G        EC    PGL T   C 
Sbjct: 265  APYTVLAQSAPREDGYSDAS----GFGYCFRELRGG--------ECASPLPGLRTQEVC- 311

Query: 1004 NTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGF 1063
                   C  AG             + +C++  +  G    V+ P      C  G+E   
Sbjct: 312  -------CRGAG---------LAWGVHDCQLCSERLGNSERVSAPDG---PCPTGFER-- 350

Query: 1064 MLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL 1123
             +  +C DVDECA     C+ G C NT G Y C CP G  L +  ++C  I +  +S+  
Sbjct: 351  -VNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISEA- 405

Query: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHC--INTEGSYR-CS 1180
               G C  V+    CS       T  +Q C      +    GC + C    +EG    C 
Sbjct: 406  --KGPCFRVLRDGGCSLPILRNIT--KQICCCSRVGKAWGRGCQL-CPPFGSEGFREICP 460

Query: 1181 CGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMAT---------- 1230
             G GY               +E PRV        +P   R     GF+ T          
Sbjct: 461  AGPGYHYSASDLRYNTRPLGQEPPRV-SLSQPRTLPATSRPSA--GFLPTHRLEPRPEPR 517

Query: 1231 PDMR-------------TCVDVDE-------CDLNPHICLHGDCENTKGSFVCHCQLGYM 1270
            PD R             T  ++ E       C  NP +C  G C +    + C C  G+ 
Sbjct: 518  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR 577

Query: 1271 VRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD--GFECHDLDECVSQ 1328
            +    T C DVDEC      C +   C N PGSF C C PG+       EC D+DEC   
Sbjct: 578  LSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC--- 633

Query: 1329 EHRCSP---RGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPG 1383
             HR  P    G C N PGS+ C C  G+  A  G  C+D DEC ++  LC  G C N PG
Sbjct: 634  -HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPG 692

Query: 1384 GYRCECEMGFDPTEDHRAC-QDVDECAQ-GNLCAFGSCENLPGMFRCICNGGYELDRGGG 1441
             +RC C  GF  +    AC +DVDECAQ    C  G C+N  G F C C  G+     G 
Sbjct: 693  SFRCVCPAGFRGS----ACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGA 748

Query: 1442 NCTDINECA-DPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1500
             C D++ECA  P  C  G C NT GS+ C CP  F+ N +G  C D           D  
Sbjct: 749  PCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDV----------DEC 798

Query: 1501 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI 1560
            ++ ++C                     G  C   P   + + RT CP G      R T  
Sbjct: 799  ENHLACP--------------------GQECVNSP--GSFQCRT-CPSGHHLHRGRCT-- 833

Query: 1561 LEDIDECQE-LPGLCQGGDCVNTFGSFQCECPPGYHL-SEHTRICEDIDECSTHSGICGP 1618
              D+DEC    P     G C NT GSF+C C PGY   S     C D++EC      C P
Sbjct: 834  --DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFP 890

Query: 1619 -GTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCS 1677
             G C NT G++ C C   Y     G +C+D+ +          CQ+ +  N      C  
Sbjct: 891  HGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC----SEEDLCQSGICTNTDGSFEC-- 944

Query: 1678 YNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEI-PAICANGI 1736
                         CP               PG          LD+DEC E  PA+C +  
Sbjct: 945  ------------ICP---------------PGHRAGPDLASCLDVDECRERGPALCGSQR 977

Query: 1737 CINQIGSFRC--ECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRC--KCT 1792
            C N  GS+RC  +C  G++       C+DVDEC            C N PGSYRC   C 
Sbjct: 978  CENSPGSYRCVRDCDPGYHAGP-EGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACD 1036

Query: 1793 RGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECD 1852
             GY+ +PGG C   +ECR      +H  C +  GS+ CLC +G++ + D   C+D++EC+
Sbjct: 1037 PGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECE 1096

Query: 1853 --RQPCGNGTCKNIIGSYNCLC 1872
              +  CG   C+N+ GS+ C+C
Sbjct: 1097 TLQGVCGAALCENVEGSFLCVC 1118



 Score =  350 bits (897), Expect = 1e-95
 Identities = 360/1213 (29%), Positives = 465/1213 (38%), Gaps = 206/1213 (16%)

Query: 68   CCPGWRTFPGRSQCVVPICR-RACGEGFCSQPNLC-TCADGTLAPSCGVSRGSGCSVSCM 125
            CCPG  +   RS+C+   CR R+C    C+ P  C        +PS  V R    S++  
Sbjct: 55   CCPGQTS--RRSRCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSV-RKRQVSLN-W 110

Query: 126  NGGTCRGASCLCQK------GYTGTVCGQP-----------ICDRGCHNGGRCIGPNRCA 168
               T + A  L ++      G  G +  +P           +C   CHNGG C+ P+RC 
Sbjct: 111  QPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCL 170

Query: 169  CVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQ 228
            C   F G  C+         G   P      LT  V T  L         G+   +    
Sbjct: 171  CPPDFAGKFCQLH-----SSGARPPAPAVPGLTRSVYTMPLANHR-DDEHGVASMVSVHV 224

Query: 229  PHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACE 288
             HP     +  +H      V+            +      +        + +   SA  E
Sbjct: 225  EHPQEASVV--VH-----QVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPRE 277

Query: 289  DYRAGA-----CFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQ 343
            D  + A     CF  L GG CA  L G  T+  CC   G  W                  
Sbjct: 278  DGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDC------------- 324

Query: 344  QLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTA 403
            QLC++RL                 S  +  P GP    P G +              G+ 
Sbjct: 325  QLCSERLG---------------NSERVSAPDGPC---PTGFERVN-----------GSC 355

Query: 404  TLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQD-VRGECIDVDECTSSPCHHGD 462
               + +D C      C +G C  T   Y C C  G+  D  R  CI     + +    G 
Sbjct: 356  ---EDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEA---KGP 408

Query: 463  CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
            C  +     C          T+Q C         G  C L     +EG F+ +C AG   
Sbjct: 409  CFRVLRDGGCSL--PILRNITKQICCCSRVGKAWGRGCQLCPPFGSEG-FREICPAG--- 462

Query: 523  SPDGKNCVDHNECATSTMCVN--GVCLNEDGSFSCLCKP--GFL----LAPGGHYCMDI- 573
             P            T  +      V L++  +     +P  GFL    L P      D  
Sbjct: 463  -PGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPR 521

Query: 574  --DECQTPGI-CVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCA 630
               E   P I    G      G     C     V   GR C+      TC  A + G   
Sbjct: 522  PGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR-CISRPSGYTC--ACDSGFRL 578

Query: 631  RPFPGT--VTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGI---TTDGRDINE 685
             P  GT  +   EC    P    G  C+  P      F+ +C  G        +  D++E
Sbjct: 579  SP-QGTRCIDVDECRRVPPPCAPGR-CENSP----GSFRCVCGPGFRAGPRAAECLDVDE 632

Query: 686  CALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPG 745
            C   P  C  G CEN  GS+ CVC  GY+A   G  C DVDEC  +  LC  G C+N PG
Sbjct: 633  CHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPG 692

Query: 746  SYSCSCPPGFHFWQDTEICKDVDECLSS--PCVSGVCRNLAGSYTCKCGPGSRLDPSGTF 803
            S+ C CP GF   + +   +DVDEC     PC  G C N AGS+ C C  G R    G  
Sbjct: 693  SFRCVCPAGF---RGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAP 749

Query: 804  CLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCE--IDPACARGFAR 861
            C D                          EC  +        CE  E      C  GF  
Sbjct: 750  CQDV------------------------DECARSPPPCTYGRCENTEGSFQCVCPMGFQP 785

Query: 862  MT-GVTCDDVNECESFPGVCPNGRCVNTAGSFRCE-CPEGLMLDASGRLCVDVRLEPCFL 919
             T G  C+DV+ECE+    CP   CVN+ GSF+C  CP G  L   GR C DV       
Sbjct: 786  NTAGSECEDVDECENHL-ACPGQECVNSPGSFQCRTCPSGHHLH-RGR-CTDV------- 835

Query: 920  RWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLS 979
                DEC    P       C  + G+     C   P               G+ +    S
Sbjct: 836  ----DECSSGAPPCGPHGHCTNTEGS---FRCSCAP---------------GYRAP---S 870

Query: 980  GRPF-YKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDL 1038
            GRP    DVNEC        HG C NT GSF C CA G+    +  +C D+DEC    DL
Sbjct: 871  GRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDL 929

Query: 1039 CGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDEC-ARDPLLCRGGTCTNTDGSYKC- 1096
            C  G C NT GSFEC C PG+ +G  L  +C+DVDEC  R P LC    C N+ GSY+C 
Sbjct: 930  CQSGICTNTDGSFECICPPGHRAGPDL-ASCLDVDECRERGPALCGSQRCENSPGSYRCV 988

Query: 1097 -QCPPGHELTAKGTACEDIDEC-SLSDGLCPHGQCVNVIGAFQC--SCHAGFQSTPDRQG 1152
              C PG+    +GT C+D+DEC      +C   +C N  G+++C  +C  G+Q TP   G
Sbjct: 989  RDCDPGYHAGPEGT-CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPG-GG 1046

Query: 1153 CVDINECRVQNGGCDVH--CINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQG 1210
            C D++ECR     C  H  C N  GS++C C QGY    DGR C DV+ECE    VC   
Sbjct: 1047 CQDVDECR-NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAA 1105

Query: 1211 HCTNMPGGHRCLC 1223
             C N+ G   C+C
Sbjct: 1106 LCENVEGSFLCVC 1118



 Score =  348 bits (894), Expect = 3e-95
 Identities = 306/999 (30%), Positives = 366/999 (36%), Gaps = 223/999 (22%)

Query: 184  TGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTG 243
            TGP   + GP     Q    VC    C   + R  G  C         C  GF  +    
Sbjct: 535  TGPEIPESGPSSGMCQRNPQVCGPGRC---ISRPSGYTCA--------CDSGFRLSPQGT 583

Query: 244  ACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303
             C DVDEC+ VP  C  G C N  GSF C C  G R           RA  C  V     
Sbjct: 584  RCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGP--------RAAECLDV----- 630

Query: 304  CAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGL 363
                      R    CD GRC                                PG F  +
Sbjct: 631  ------DECHRVPPPCDLGRC-----------------------------ENTPGSFLCV 655

Query: 364  LGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGR 423
               G              PHG+                     Q +D C     LC  G 
Sbjct: 656  CPAGYQAA----------PHGASC-------------------QDVDECTQSPGLCGRGA 686

Query: 424  CLPTPSSYRCECNVGYTQDVRGECIDVDECTSSP--CHHGDCVNIPGTYHCRCYPGFQAT 481
            C   P S+RC C  G+      E  DVDEC   P  C  G C N  G++HC C  GF++ 
Sbjct: 687  CKNLPGSFRCVCPAGFRGSACEE--DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSR 744

Query: 482  PTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMC 541
                 C DVDEC  S   C  GRC NTEGSFQCVC  GF+ +  G  C D +EC     C
Sbjct: 745  GPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLAC 804

Query: 542  VNGVCLNEDGSFSC-LCKPGFLLAPGGHYCMDIDECQT--PGICVNGHCTNTEGSFRCQC 598
                C+N  GSF C  C  G  L  G   C D+DEC +  P    +GHCTNTEGSFRC C
Sbjct: 805  PGQECVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 862

Query: 599  LGGLAV--GTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQ 656
              G     G  G  C D +        +E   C   FP         C N D  F   C 
Sbjct: 863  APGYRAPSGRPG-PCADVN------ECLEGDFC---FPHGE------CLNTDGSFA--CT 904

Query: 657  LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAG 716
              P        A C           D++EC+ + ++C +G+C N  GS+ C+C  G+ AG
Sbjct: 905  CAPGYRPGPRGASC----------LDVDECS-EEDLCQSGICTNTDGSFECICPPGHRAG 953

Query: 717  ASGKDCTDVDEC-ALNSLLCDNGWCQNSPGSYSC--SCPPGFHFWQDTEICKDVDECLS- 772
                 C DVDEC      LC +  C+NSPGSY C   C PG+H   +   C DVDEC   
Sbjct: 954  PDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE-GTCDDVDECQEY 1012

Query: 773  SPCVSGV--CRNLAGSYTC--KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828
             P + G   C N  GSY C   C PG +  P G  C D         + E R   N    
Sbjct: 1013 GPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG-CQD---------VDECR---NRSFC 1059

Query: 829  SLRSECCATLGAAWGSPCERCEIDPACARGF-ARMTGVTCDDVNECESFPGVCPNGRCVN 887
               + C    G+              C +G+     G  C DVNECE+  GVC    C N
Sbjct: 1060 GAHAVCQNLPGS----------FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCEN 1109

Query: 888  TAGSFRCECPEG-LMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAV 946
              GSF C CP      D     CV  R               T PG            A 
Sbjct: 1110 VEGSFLCVCPNSPEEFDPMTGRCVPPRTS-----------AGTFPGSQPQ--------AP 1150

Query: 947  WGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTV 1006
                  A P P  L      PR     S      R  Y D       P  C +   RN  
Sbjct: 1151 ASPVLPARPPPPPLPRRPSTPRQGPVGS----GRRECYFDT----AAPDACDNILARNVT 1202

Query: 1007 GSFHCACAG-GFALDAQERNC----------------------------TDIDECRISPD 1037
                C   G G+    + + C                             D+DEC++  D
Sbjct: 1203 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRD 1262

Query: 1038 -LCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKC 1096
             +C  G CVNT   + C C  GY      ++ C+D DECA +   C GG C NT GSY C
Sbjct: 1263 QVCKSGVCVNTAPGYSCYCSNGYYYHTQRLE-CIDNDECADEEPACEGGRCVNTVGSYHC 1321

Query: 1097 QCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGA 1135
             C P   L      C   +  SL D L   G C   +GA
Sbjct: 1322 TCEPPLVLDGSQRRCVSNESQSLDDNL---GVCWQEVGA 1357



 Score =  344 bits (882), Expect = 8e-94
 Identities = 272/913 (29%), Positives = 350/913 (38%), Gaps = 187/913 (20%)

Query: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLG 1626
            CQ  P +C  G C++    + C C  G+ LS     C D+DEC      C PG C N+ G
Sbjct: 549  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG 608

Query: 1627 NYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNR 1686
            ++ CVC   +        C+D+ +  C R     C      N      C           
Sbjct: 609  SFRCVCGPGFRAGPRAAECLDVDE--CHR-VPPPCDLGRCENTPGSFLC----------- 654

Query: 1687 PCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRC 1746
                CP                G+    H     D+DEC + P +C  G C N  GSFRC
Sbjct: 655  ---VCPA---------------GYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRC 696

Query: 1747 ECPAGFNYNSILLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL-SPGGACV 1804
             CPAGF  +    ACE DVDEC     PC     C N  GS+ C C  G++   PG  C 
Sbjct: 697  VCPAGFRGS----ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQ 751

Query: 1805 GRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ-PCGNGTCKN 1863
              +EC   P  C++G C +TEGS+ C+C  GFQ +   + C D+DEC+    C    C N
Sbjct: 752  DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVN 811

Query: 1864 IIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTAD 1923
              GS+ C   P     H G C D DEC++        GHC NT GSF C C  G+   + 
Sbjct: 812  SPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSG 871

Query: 1924 GKN-CVDTNECLSLAGTCLP-GTCQNLEGSFRCICPPGFQV--QSDHCIDIDECSEEPNL 1979
                C D NECL     C P G C N +GSF C C PG++   +   C+D+DECSEE +L
Sbjct: 872  RPGPCADVNECLE-GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE-DL 929

Query: 1980 CLFGTCTNSPGSFQCLCPPGFVLSDN-------------------GHRCFDTRQSF---- 2016
            C  G CTN+ GSF+C+CPPG     +                     RC ++  S+    
Sbjct: 930  CQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 989

Query: 2017 -CFTRFEAGK-----------------CSVPKAFNTTKTRCCC-------SKRPGEGWGD 2051
             C   + AG                  C   +  NT  +  C           PG G  D
Sbjct: 990  DCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQD 1049

Query: 2052 PCE-----------LCPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNG 2098
              E           +C Q    +FQ LC  G+    G  D R   DVNEC    GVC   
Sbjct: 1050 VDECRNRSFCGAHAVC-QNLPGSFQCLCDQGY---EGARDGRHCVDVNECETLQGVCGAA 1105

Query: 2099 -----------VCVNTDGSF-----RCECPFGYSLDFTGIN-----------------CV 2125
                       VC N+   F     RC  P   +  F G                     
Sbjct: 1106 LCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLP 1165

Query: 2126 DTDECSVGHPCGQG------------TCTNVIGGF----ECACADGFEPGLMMTCEDIDE 2169
                     P G G             C N++       EC C  G   G          
Sbjct: 1166 RRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWG--------SG 1217

Query: 2170 CSLNPLLCAFRCHNTE-GSYLCTCPAG---YTLREDGAMCRDVDECADGQQDCHARGMEC 2225
            C +       +C  TE   Y   CP G        D ++ RDVDEC   +      G+ C
Sbjct: 1218 CRIQ------QCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV-C 1270

Query: 2226 KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD----- 2280
             N    ++C C  G        E C D++EC  +   C  GRCVNT GS+ C C+     
Sbjct: 1271 VNTAPGYSCYCSNGYYYHTQRLE-CIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1329

Query: 2281 EGFQPSPTLTECH--DIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL 2338
            +G Q      E    D   G C+ EV   +  S        T  ECCC  G  WG  C L
Sbjct: 1330 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1389

Query: 2339 CPLPGTSAYRKLC 2351
            CP   +  +  LC
Sbjct: 1390 CPAQDSDDFEALC 1402



 Score =  340 bits (873), Expect = 9e-93
 Identities = 195/490 (39%), Positives = 243/490 (49%), Gaps = 46/490 (9%)

Query: 2170 CSLNPLLCA-FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNL 2228
            C  NP +C   RC +    Y C C +G+ L   G  C DVDEC      C A G  C+N 
Sbjct: 549  CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APG-RCENS 606

Query: 2229 IGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPT 2288
             G+F CVC PG R  P + E C D +ECH  P  C  GRC NT GSF C C  G+Q +P 
Sbjct: 607  PGSFRCVCGPGFRAGPRAAE-CLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPH 665

Query: 2289 LTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYR 2348
               C D+                     +  T++   CG G      C+   LPG+  +R
Sbjct: 666  GASCQDV---------------------DECTQSPGLCGRGA-----CK--NLPGS--FR 695

Query: 2349 KLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDE 2408
             +CP G   +A   DVDEC      C  G C N+ GSF C C AG+        C D+DE
Sbjct: 696  CVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 755

Query: 2409 CSQVPKPCTF-LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGA 2467
            C++ P PCT+  C+NT+GSF C CP G+     G  C+D+DEC +        CVN+ G+
Sbjct: 756  CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGS 815

Query: 2468 FTCR-CPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHG- 2525
            F CR CP G   H   C D DECS+   PCG HGHC NT GSFRC C  G+   S   G 
Sbjct: 816  FQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 875

Query: 2526 CEDVNEC-DGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSAS 2583
            C DVNEC +G     HG C N  G + C+C  G+    + A C+D +EC+     C S  
Sbjct: 876  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDLCQSGI 934

Query: 2584 CRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPC---SYSCANTPGGFLC--GCPQ 2638
            C NT G F C+CP G      L  C +VDEC   RGP    S  C N+PG + C   C  
Sbjct: 935  CTNTDGSFECICPPGHRAGPDLASCLDVDECR-ERGPALCGSQRCENSPGSYRCVRDCDP 993

Query: 2639 GYFRAGQGHC 2648
            GY    +G C
Sbjct: 994  GYHAGPEGTC 1003



 Score =  291 bits (745), Expect = 6e-78
 Identities = 336/1223 (27%), Positives = 443/1223 (36%), Gaps = 283/1223 (23%)

Query: 33   WDGA-LEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCP---GWRTFPGRSQCV-VPICR 87
            W G  +  +GP     + +P +  GP  C SR   Y C    G+R  P  ++C+ V  CR
Sbjct: 534  WTGPEIPESGPSSGMCQRNPQVC-GPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECR 592

Query: 88   RA-------------------CGEGFCSQPNLCTCAD----GTLAPSCGVSRGSGCSVSC 124
            R                    CG GF + P    C D      + P C + R       C
Sbjct: 593  RVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR-------C 645

Query: 125  MNGGTCRGASCLCQKGYTGTVCGQP------------ICDRG-CHNGGRCIGPNRCACVY 171
             N  T     C+C  GY     G              +C RG C N     G  RC C  
Sbjct: 646  EN--TPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKN---LPGSFRCVCPA 700

Query: 172  GFMGPQCERDY-----RTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
            GF G  CE D         PC    GP  C +      C                   CP
Sbjct: 701  GFRGSACEEDVDECAQEPPPC----GPGRCDNTAGSFHCA------------------CP 738

Query: 227  AQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286
            A       GF        CQDVDEC   P  C  G C N  GSF C CP+G + + + + 
Sbjct: 739  A-------GFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE 791

Query: 287  CEDYR---------AGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPR 337
            CED              C +     +C    +GH+  R  C D   C +  P    C P 
Sbjct: 792  CEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPP---CGPH 848

Query: 338  G-----SNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS 392
            G        F+  CA      PG+                                  PS
Sbjct: 849  GHCTNTEGSFRCSCA------PGYRA--------------------------------PS 870

Query: 393  LGPGNSNIGTATLNQTIDICRHFTNLCL-NGRCLPTPSSYRCECNVGYTQDVRG-ECIDV 450
              PG      A +N+ ++      + C  +G CL T  S+ C C  GY    RG  C+DV
Sbjct: 871  GRPGPC----ADVNECLE-----GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDV 921

Query: 451  DECTSSP-CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSG-GLCHLGRCVNT 508
            DEC+    C  G C N  G++ C C PG +A P   +C+DVDEC   G  LC   RC N+
Sbjct: 922  DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENS 981

Query: 509  EGSFQCV--CNAGFELSPDGKNCVDHNECAT--STMCVNGVCLNEDGSFSCL--CKPGFL 562
             GS++CV  C+ G+   P+G  C D +EC      +C    C N  GS+ C   C PG+ 
Sbjct: 982  PGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ 1040

Query: 563  LAPGGHYCMDIDECQTPGIC-VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCY 621
              PGG  C D+DEC+    C  +  C N  GSF+C C  G     DGR CVD +   T  
Sbjct: 1041 PTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1099

Query: 622  GAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLC-PAKDSA------EFQALCSSGL 674
            G      C       +    C C N    F      C P + SA      + QA  S  L
Sbjct: 1100 GVCGAALCENVEGSFL----CVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVL 1155

Query: 675  ------------------GITTDGRDINECALD---PEVCANGVCENLRGSYRCVCNLG- 712
                              G    GR   EC  D   P+ C N +  N+     C C +G 
Sbjct: 1156 PARPPPPPLPRRPSTPRQGPVGSGR--RECYFDTAAPDACDNILARNVTWQ-ECCCTVGE 1212

Query: 713  -YEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL 771
             + +G   + C   +     SL C +G    +P               D  + +DVDEC 
Sbjct: 1213 GWGSGCRIQQCPGTETAEYQSL-CPHGRGYLAPSG-------------DLSLRRDVDECQ 1258

Query: 772  ---SSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828
                  C SGVC N A  Y+C C  G         C+D+ +       +E  CE      
Sbjct: 1259 LFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDE----CADEEPACE------ 1308

Query: 829  SLRSECCATLGAAWGSPCER-CEIDPACARGFARMTGVTCDDVNECESFPG---VCPNGR 884
                 C  T+G+ +   CE    +D +  R  +  +    D++  C    G   VC + R
Sbjct: 1309 --GGRCVNTVGS-YHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPR 1365

Query: 885  CVNTAGSFRCECPEGLMLDASGRLC-----------VDVRLEPCFLRWDEDECGVTLPGK 933
                A    C C  G        LC            +V   P +        G  LP +
Sbjct: 1366 LDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYS--PPRPGGFGLPYE 1423

Query: 934  YRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYK-------- 985
            Y  D+     G  +G E      P +L +    P    FA R+   G P +         
Sbjct: 1424 YGPDLGPPYQGLPYGPELYP---PPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDG 1480

Query: 986  ---DVNECKVFPGLCTHGT--CRNTVGSFH--------CACAGGFALDAQERNCTDIDEC 1032
                 +E    PG  T      R+T  SF          + AG  A   +E    + +EC
Sbjct: 1481 GPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEE---LEAEEC 1537

Query: 1033 RISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDEC----ARDPLLCRGGTCT 1088
             I  D C  G CV  P  F C CF GY      M  C+D++EC    A  PL C    C 
Sbjct: 1538 GIL-DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMA-CVDINECDEAEAASPL-CVNARCL 1594

Query: 1089 NTDGSYKCQCPPGHELTAKGTAC 1111
            NTDGS++C C PG   T +   C
Sbjct: 1595 NTDGSFRCICRPGFAPTHQPHHC 1617



 Score =  247 bits (630), Expect = 1e-64
 Identities = 176/548 (32%), Positives = 224/548 (40%), Gaps = 54/548 (9%)

Query: 2152 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC 2211
            C  GFE  +  +CED+DEC+         C NT G Y C CP G+ L    + C      
Sbjct: 344  CPTGFER-VNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVI 402

Query: 2212 ADGQQDCHA--RGMEC-----KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCV 2264
            ++ +  C    R   C     +N+     C    G       G GC           LC 
Sbjct: 403  SEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGK----AWGRGC----------QLCP 448

Query: 2265 NGRCVNTAGSFRCDCDEG----FQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEA-- 2318
                   +  FR  C  G    +  S        + Q P    + Q      +S   A  
Sbjct: 449  PFG----SEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGF 504

Query: 2319 --VTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAH 2376
                R E          P  EL PLP   A+      G      G     C+    +C  
Sbjct: 505  LPTHRLEPRPEPRPDPRPGPEL-PLPSIPAWT-----GPEIPESGPSSGMCQRNPQVCGP 558

Query: 2377 GECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCT-FLCKNTKGSFLCSCPRGY 2435
            G CI+    + C C +G+      T C+D+DEC +VP PC    C+N+ GSF C C  G+
Sbjct: 559  GRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGF 618

Query: 2436 LLEEDGRTCKDLDECTSRQHNCQF-LCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQ 2492
                    C D+DEC      C    C NT G+F C CP G+    H  +C D DEC+  
Sbjct: 619  RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQS 678

Query: 2493 PGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNEC-DGPHRCQHG-CQNQLGGY 2549
            PG CG  G C N PGSFRC C  GF     G  CE DV+EC   P  C  G C N  G +
Sbjct: 679  PGLCG-RGACKNLPGSFRCVCPAGFR----GSACEEDVDECAQEPPPCGPGRCDNTAGSF 733

Query: 2550 RCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQ 2609
             C+CP GF      A C D +ECA SPP C    C NT G F+CVCP GF  + A   C+
Sbjct: 734  HCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE 793

Query: 2610 EVDECAGRRGPCSYSCANTPGGFLC-GCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELL 2668
            +VDEC          C N+PG F C  CP G+    +G C      S G           
Sbjct: 794  DVDECENHLACPGQECVNSPGSFQCRTCPSGH-HLHRGRCTDVDECSSGAPPCGPHGHCT 852

Query: 2669 SSEACYEC 2676
            ++E  + C
Sbjct: 853  NTEGSFRC 860



 Score =  238 bits (608), Expect = 5e-62
 Identities = 166/497 (33%), Positives = 215/497 (43%), Gaps = 72/497 (14%)

Query: 2198 LREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV------CPPGMRPLPGSGEGCT 2251
            LR     CR     A G  DC      C   +G    V      CP G   + GS   C 
Sbjct: 305  LRTQEVCCRGAG-LAWGVHDCQL----CSERLGNSERVSAPDGPCPTGFERVNGS---CE 356

Query: 2252 DDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC---HDIRQ--GPCFAEVLQ 2306
            D +EC A    C +G C NT G + C C +GF    + + C   H I +  GPCF  +  
Sbjct: 357  DVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRD 415

Query: 2307 TMCRSLSSSSEAVTRAECCCGG-GRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRD-- 2363
              C SL      +T+  CCC   G+ WG  C+LCP  G+  +R++CP G GY     D  
Sbjct: 416  GGC-SLPILRN-ITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLR 473

Query: 2364 --------------VDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
                          + + R L            L + R   +    PD      L +   
Sbjct: 474  YNTRPLGQEPPRVSLSQPRTLP--ATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSI 531

Query: 2410 -----SQVPK--PCTFLCK------------NTKGSFLCSCPRGYLLEEDGRTCKDLDEC 2450
                  ++P+  P + +C+            +    + C+C  G+ L   G  C D+DEC
Sbjct: 532  PAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDEC 591

Query: 2451 TSRQHNC-QFLCVNTVGAFTCRCPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPG 2507
                  C    C N+ G+F C C PGF    +A  C D DEC   P PC   G C NTPG
Sbjct: 592  RRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL-GRCENTPG 650

Query: 2508 SFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQ 2565
            SF C C  G+     G  C+DV+EC   P  C  G C+N  G +RC CP GF    + + 
Sbjct: 651  SFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF----RGSA 706

Query: 2566 C-VDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYS 2624
            C  D +ECA  PP CG   C NT G F C CP+GF        CQ+VDECA    PC+Y 
Sbjct: 707  CEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYG 766

Query: 2625 -CANTPGGFLCGCPQGY 2640
             C NT G F C CP G+
Sbjct: 767  RCENTEGSFQCVCPMGF 783



 Score =  137 bits (345), Expect = 1e-31
 Identities = 112/393 (28%), Positives = 147/393 (37%), Gaps = 57/393 (14%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR-CELCPLPGTSAYRKLCPHGSG 2356
            G CF E+    C S        T+  CC G G  WG   C+LC     ++ R   P G  
Sbjct: 287  GYCFRELRGGECASPLPGLR--TQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPC 344

Query: 2357 YTAEGR------DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECS 2410
             T   R      DVDEC      C HGEC N+ G + C C  G+  D++ ++C+     S
Sbjct: 345  PTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVIS 403

Query: 2411 QVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTC 2470
            +   PC  + ++      CS P    + +    C  + +   R   CQ         F  
Sbjct: 404  EAKGPCFRVLRDGG----CSLPILRNITKQICCCSRVGKAWGR--GCQLCPPFGSEGFRE 457

Query: 2471 RCPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPGSFR------------------ 2510
             CP G   H+ A     N     Q  P  +       P + R                  
Sbjct: 458  ICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR 517

Query: 2511 -------------CECHQGFTLVSSGHG---CEDVNECDGPHRCQHGCQNQLGGYRCSCP 2554
                              G  +  SG     C+   +  GP R    C ++  GY C+C 
Sbjct: 518  PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGR----CISRPSGYTCACD 573

Query: 2555 QGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC 2614
             GF    Q  +C+D +EC   PP C    C N+ G FRCVC  GF        C +VDEC
Sbjct: 574  SGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDEC 633

Query: 2615 AGRRGPCSYS-CANTPGGFLCGCPQGYFRAGQG 2646
                 PC    C NTPG FLC CP GY  A  G
Sbjct: 634  HRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHG 666



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 5/87 (5%)

Query: 1113 DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG----CDV 1168
            + +EC + DG C +G+CV V   F C C  G++    R  CVDINEC           + 
Sbjct: 1533 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 1169 HCINTEGSYRCSCGQGYSLMPDGRACA 1195
             C+NT+GS+RC C  G++       CA
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHCA 1618



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 35/88 (39%), Positives = 44/88 (50%), Gaps = 7/88 (7%)

Query: 1885 VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNEC---LSLAGTCL 1941
            ++ +EC  L G  C  G C+     F C C DG+ L      CVD NEC    + +  C+
Sbjct: 1532 LEAEECGILDG--CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV 1589

Query: 1942 PGTCQNLEGSFRCICPPGFQV--QSDHC 1967
               C N +GSFRCIC PGF    Q  HC
Sbjct: 1590 NARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 32/93 (34%), Positives = 42/93 (45%), Gaps = 4/93 (4%)

Query: 530  VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ----TPGICVNG 585
            ++  EC     C NG C+     F+C C  G+ L      C+DI+EC        +CVN 
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 586  HCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS 618
             C NT+GSFRC C  G A       C     R+
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA 1624



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 32/91 (35%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1928 VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPN---LCLF 1982
            ++  EC  L G C  G C  +   F C C  G+++      C+DI+EC E      LC+ 
Sbjct: 1532 LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590

Query: 1983 GTCTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013
              C N+ GSF+C+C PGF  +   H C   R
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 56/220 (25%), Positives = 82/220 (37%), Gaps = 24/220 (10%)

Query: 8   LARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAY 67
           +AR   A    A +    +A    R DG  +A+G G   R    G    P + G R    
Sbjct: 252 VARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASP-LPGLRTQEV 310

Query: 68  CCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVS-CMN 126
           CC G     G   C      + C E   +   + +  DG          GS   V  C  
Sbjct: 311 CCRGAGLAWGVHDC------QLCSERLGNSERV-SAPDGPCPTGFERVNGSCEDVDECAT 363

Query: 127 GGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGP 186
           GG C+   C   +G    VC            G  +  +R +C+   +  + +     GP
Sbjct: 364 GGRCQHGECANTRGGYTCVCPD----------GFLLDSSRSSCISQHVISEAK-----GP 408

Query: 187 CFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
           CF  +   GC   +   +  +  CC+ VG+AWG  C+LCP
Sbjct: 409 CFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP 448



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 5/99 (5%)

Query: 1141 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC 1200
            +AG  + P  +  ++  EC + +G  +  C+     + C C  GY L     AC D++EC
Sbjct: 1521 YAGSLAEPYEE--LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINEC 1578

Query: 1201 EENPR---VCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236
            +E      +C    C N  G  RC+C  GF  T     C
Sbjct: 1579 DEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 33/90 (36%), Positives = 40/90 (44%), Gaps = 13/90 (14%)

Query: 1318 ECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGD--GFFCEDRDECAENV---DL 1372
            EC  LD C +        G C+ VP  + C C  G+  D     C D +EC E      L
Sbjct: 1536 ECGILDGCTN--------GRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL 1587

Query: 1373 CDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402
            C N +CLN  G +RC C  GF PT     C
Sbjct: 1588 CVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 36/95 (37%), Positives = 43/95 (45%), Gaps = 13/95 (13%)

Query: 2205 CRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNEC---HAQPD 2261
            C  +D C +G+         C  +   F C C  G R L  +   C D NEC    A   
Sbjct: 1537 CGILDGCTNGR---------CVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASP 1586

Query: 2262 LCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296
            LCVN RC+NT GSFRC C  GF P+     C   R
Sbjct: 1587 LCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 1082 CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDG---LCPHGQCVNVIGAFQC 1138
            C  G C      + C+C  G+ L     AC DI+EC  ++    LC + +C+N  G+F+C
Sbjct: 1543 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRC 1602

Query: 1139 SCHAGFQSTPDRQGC 1153
             C  GF  T     C
Sbjct: 1603 ICRPGFAPTHQPHHC 1617



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 31/94 (32%), Positives = 41/94 (43%), Gaps = 11/94 (11%)

Query: 2352 PHGSGYTA------EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLD 2405
            P G  Y        E  + +EC +L   C +G C+     F C C  GY  D T   C+D
Sbjct: 1516 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1574

Query: 2406 MDECSQV----PKPCTFLCKNTKGSFLCSCPRGY 2435
            ++EC +     P      C NT GSF C C  G+
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1608



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 1563 DIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDEC---STHSGICGPG 1619
            + +EC  L G C  G CV     F C C  GY L      C DI+EC      S +C   
Sbjct: 1533 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 1620 TCYNTLGNYTCVCPAEYLQVNGGNNCMDMR 1649
             C NT G++ C+C   +   +  ++C   R
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 35/114 (30%), Positives = 47/114 (41%), Gaps = 18/114 (15%)

Query: 1224 YDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
            Y G +A P     ++ +EC +    C +G C      F C C  GY +      C D++E
Sbjct: 1521 YAGSLAEPYEE--LEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE 1577

Query: 1284 C---EVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSP 1334
            C   E     C  +A CLN  GSF C C PG+               Q H C+P
Sbjct: 1578 CDEAEAASPLC-VNARCLNTDGSFRCICRPGFAP-----------THQPHHCAP 1619



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 28/76 (36%), Positives = 35/76 (46%), Gaps = 4/76 (5%)

Query: 2528 DVNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENEC---ALSPPTCGSAS 2583
            +  EC     C +G C     G+ C C  G+        CVD NEC     + P C +A 
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592

Query: 2584 CRNTLGGFRCVCPSGF 2599
            C NT G FRC+C  GF
Sbjct: 1593 CLNTDGSFRCICRPGF 1608



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 29/85 (34%), Positives = 35/85 (41%), Gaps = 7/85 (8%)

Query: 2487 DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-----GPHRCQHG 2541
            +EC    G C  +G C   P  F C C  G+ L  +   C D+NECD      P      
Sbjct: 1535 EECGILDG-C-TNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592

Query: 2542 CQNQLGGYRCSCPQGFTQHSQWAQC 2566
            C N  G +RC C  GF    Q   C
Sbjct: 1593 CLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 26/82 (31%), Positives = 35/82 (42%), Gaps = 4/82 (4%)

Query: 2404 LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL--- 2460
            L+ +EC  +       C      F C C  GY L+     C D++EC   +         
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 2461 -CVNTVGAFTCRCPPGFTQHHQ 2481
             C+NT G+F C C PGF   HQ
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQ 1613



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 31/90 (34%), Positives = 38/90 (42%), Gaps = 6/90 (6%)

Query: 830  LRSECCATLGAAWGSPCERCE--IDPACARGFAR-MTGVTCDDVNEC---ESFPGVCPNG 883
            L +E C  L       C R        C  G+   MT + C D+NEC   E+   +C N 
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
            RC+NT GSFRC C  G         C   R
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTHQPHHCAPAR 1621



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 8/101 (7%)

Query: 2554 PQGFTQHSQWAQCVDE---NECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQE 2610
            P+G +     A+  +E    EC +    C +  C     GF C C  G+  D     C +
Sbjct: 1516 PEGGSYAGSLAEPYEELEAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD 1574

Query: 2611 VDEC--AGRRGPCSYS--CANTPGGFLCGCPQGYFRAGQGH 2647
            ++EC  A    P   +  C NT G F C C  G+    Q H
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPH 1615



 Score = 40.4 bits (93), Expect = 0.025
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 3/61 (4%)

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPG---LCQGGDCVNTFGSFQCECPPGYHLSEHTRI 1602
            C   +G++ +   +   DI+EC E      LC    C+NT GSF+C C PG+  +     
Sbjct: 1557 CRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHH 1616

Query: 1603 C 1603
            C
Sbjct: 1617 C 1617



 Score = 38.9 bits (89), Expect = 0.072
 Identities = 14/34 (41%), Positives = 21/34 (61%)

Query: 2363 DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTP 2396
            + DE    + LC +  C+N+ GSFRC C+ G+ P
Sbjct: 1577 ECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP 1610



 Score = 37.4 bits (85), Expect = 0.21
 Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 11/94 (11%)

Query: 247  DVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDY----RAGACFSVLFGG 302
            + +EC  + G C  G CV +   F CRC  G+RL  +  AC D      A A   +    
Sbjct: 1533 EAEECGILDG-CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591

Query: 303  RCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPP 336
            RC  +  G +   +C C  G  +A    P  C P
Sbjct: 1592 RCL-NTDGSF---RCICRPG--FAPTHQPHHCAP 1619



 Score = 36.6 bits (83), Expect = 0.36
 Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 3/66 (4%)

Query: 232  CRRGFIPNIHTGACQDVDEC---QAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACE 288
            C  G+  ++   AC D++EC   +A   LC    C+N  GSF C C  G   +     C 
Sbjct: 1559 CFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCA 1618

Query: 289  DYRAGA 294
              R  A
Sbjct: 1619 PARPRA 1624



 Score = 36.2 bits (82), Expect = 0.47
 Identities = 15/37 (40%), Positives = 19/37 (51%)

Query: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
            D C NGRCV     F C C +G++   T   C DI +
Sbjct: 1541 DGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINE 1577


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  532 bits (1370), Expect = e-150
 Identities = 304/848 (35%), Positives = 426/848 (50%), Gaps = 102/848 (12%)

Query: 1027 TDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGT 1086
            T+I+EC ++PD+CG G C+N P  + C C+ GY       + C+D+DEC +   LC  G 
Sbjct: 873  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQ-QRKCVDIDECTQVQHLCSQGR 931

Query: 1087 CTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCS-CHAGFQ 1145
            C NT+GS+ C CP G   + +GT C D+DEC L   +C  G CVN +GAF+C  C +G++
Sbjct: 932  CENTEGSFLCICPAGFMASEEGTNCIDVDEC-LRPDVCGEGHCVNTVGAFRCEYCDSGYR 990

Query: 1146 STPDRQGCVDINECRVQNGGCDVHCINTEGSYRC-SCGQGYSLMPDGRACADVDECEENP 1204
             T  R  C DI+EC   +   D  C+N+ GSY+C  C +G+        C DVDEC E P
Sbjct: 991  MT-QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGW--NGQCLDVDECLE-P 1046

Query: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCH 1264
             VC  G C+N+ G + C C+ G+  TPD + C D+DEC    ++C++G C+NT+GSF C 
Sbjct: 1047 NVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQ-QGNLCVNGQCKNTEGSFRCT 1105

Query: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGW--VGDGFECHDL 1322
            C  GY +      C D+DEC+   H C +H  C N  GSF C C  G+   G G  C D+
Sbjct: 1106 CGQGYQLSAAKDQCEDIDECQ-HRHLC-AHGQCRNTEGSFQCVCDQGYRASGLGDHCEDI 1163

Query: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGF-AGDGFFCEDRDECAENVDLC-DNGQCLN 1380
            +EC+  +  C  RGDC+N  GSY CTC  GF   D   C+D +EC E+  LC   G+CLN
Sbjct: 1164 NECLEDKSVCQ-RGDCINTAGSYDCTCPDGFQLDDNKTCQDINEC-EHPGLCGPQGECLN 1221

Query: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLC-AFGSCENLPGMFRCICNGGYELDRG 1439
              G + C C+ GF  + D R C+D+DEC    +C + G C+N  G FRC+C  G++  + 
Sbjct: 1222 TEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQD 1281

Query: 1440 GGNCTDINECADPVN-CINGVCINTPGSYLCSC-PQDFELNPSGVGC---------VDT- 1487
            G  C D+NEC      C    C N  GS+LC C  ++ E +P    C         VD  
Sbjct: 1282 GQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVD 1341

Query: 1488 ----RAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCEL--CPMANTTE 1541
                    C+   +D       C   +   VT+  CCC+ G  WG+ CE+  CP+  T E
Sbjct: 1342 QPKEEKKECYYNLNDAS----LCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE 1397

Query: 1542 YRTLCPGGEGFQPNRITVI------LEDIDEC----QELPGLCQGGDCVNTFGSFQCECP 1591
            +  +CP G+GF P   +         +D DEC    QE   +C+ G C+NT   ++C C 
Sbjct: 1398 FTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE---ICKNGFCLNTRPGYECYCK 1454

Query: 1592 PGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCM----- 1646
             G +       C D+DEC   S  C  G C NT G+Y C C    +       C+     
Sbjct: 1455 QGTYYDPVKLQCFDMDECQDPSS-CIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAES 1513

Query: 1647 -------DMRKSVCFRHYNG--TCQNEL-AFNVTRKMCCCSYNIGQAWNRPCEACPTPIS 1696
                   D+ + +C+ H +    C   L     T   CCC Y  G+AW   C  CP   S
Sbjct: 1514 NEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY--GEAWGMQCALCPLKDS 1571

Query: 1697 PDYQILC-----------GNQA-------------PGFLTD--IHTGKPLDIDECGEIPA 1730
             DY  LC           G  A             P F+ D  +++ + L  +ECG +  
Sbjct: 1572 DDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG 1631

Query: 1731 ICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC---GSRESPCQQNADCINIPGSY 1787
             C NG C+     + C+C  G++ ++  + C DV+EC    +R S C +NA CIN  GSY
Sbjct: 1632 -CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNAKCINTDGSY 1689

Query: 1788 RCKCTRGY 1795
            +C C  GY
Sbjct: 1690 KCLCLPGY 1697



 Score =  472 bits (1215), Expect = e-132
 Identities = 360/1197 (30%), Positives = 502/1197 (41%), Gaps = 184/1197 (15%)

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGL-PCELCPAQPH--------PCRRG 235
            G CF +     C   L GL   +  CC TVG +WG   C+ CP +P          C  G
Sbjct: 557  GRCFQETIGSQCGKALPGL-SKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPG 615

Query: 236  FIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACE------D 289
            +   ++   CQD++ECQ + G+C  G C+N +GS+ C C +G     + ++C        
Sbjct: 616  Y-KRVNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVIS 673

Query: 290  YRAGACFSVLFGGR-CAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLC-- 346
               G C+ ++  GR C   L+ H T++ CCC  G+ W  GP  E CP  G+  F+++C  
Sbjct: 674  EEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAW--GPHCEKCPLPGTAAFKEICPG 731

Query: 347  --------AQRLPLLPGHPGLFPGLL------GFGSNGMGPPL----------------G 376
                      R   +  H G  P  +          +   PPL                G
Sbjct: 732  GMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHG 791

Query: 377  PARLNPHGSDA---RGIPSLG-------PGNSNIGTATLNQTIDICRHFTNLCLNGRCLP 426
            P    P  + A   + IPSL        PG   +       TI +   F  + +     P
Sbjct: 792  PGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGI--STIHLHPQFPGIVIEKTSPP 849

Query: 427  TPSSYRCECNVGYTQDVRG--ECIDVDECTSSP--CHHGDCVNIPGTYHCRCYPGFQATP 482
             P     E +      V    +  +++ECT +P  C  G C+N+P  Y C CY G++ + 
Sbjct: 850  VPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSE 909

Query: 483  TRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV 542
             ++ CVD+DEC     LC  GRC NTEGSF C+C AGF  S +G NC+D +EC    +C 
Sbjct: 910  QQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCG 969

Query: 543  NGVCLNEDGSFSC-LCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRC-QCLG 600
             G C+N  G+F C  C  G+ +   G  C DIDEC  P  C +  C N+ GS++C  C  
Sbjct: 970  EGHCVNTVGAFRCEYCDSGYRMTQRGR-CEDIDECLNPSTCPDEQCVNSPGSYQCVPCTE 1028

Query: 601  GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN------PDHGFG-- 652
            G   G +G+ C+D          +E   CA      +  S  C  +      PDH     
Sbjct: 1029 GFR-GWNGQ-CLDVD------ECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRD 1080

Query: 653  -EPCQ---LCP----AKDSAEFQALCSSGLGITT---DGRDINECALDPEVCANGVCENL 701
             + CQ   LC           F+  C  G  ++       DI+EC     +CA+G C N 
Sbjct: 1081 IDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ-HRHLCAHGQCRNT 1139

Query: 702  RGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDT 761
             GS++CVC+ GY A   G  C D++EC  +  +C  G C N+ GSY C+CP GF    D 
Sbjct: 1140 EGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDN 1198

Query: 762  EICKDVDEC----LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQ 817
            + C+D++EC    L  P   G C N  GS+ C C  G  +   G  C D         I 
Sbjct: 1199 KTCQDINECEHPGLCGP--QGECLNTEGSFHCVCQQGFSISADGRTCED---------ID 1247

Query: 818  ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF-ARMTGVTCDDVNECESF 876
            E    VN         C  T G+       RC     C +GF A   G  C DVNECE  
Sbjct: 1248 EC---VNNTVCDSHGFCDNTAGSF------RC----LCYQGFQAPQDGQGCVDVNECELL 1294

Query: 877  PGVCPNGRCVNTAGSFRCECPE----------GLMLDASGRLCVDV-----RLEPCFLRW 921
             GVC    C N  GSF C C +                S  L VDV       + C+   
Sbjct: 1295 SGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNL 1354

Query: 922  -DEDECGVTLPGKYRMDVCCCSIGAVWGVECE--ACPDPESLEFASLCPRGLGFASRDFL 978
             D   C   L        CCC+ GA WG  CE   CP   + EF  +CP+G GF      
Sbjct: 1355 NDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGES 1414

Query: 979  S---GRPFYKDVNECKVF-PGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRI 1034
            S   G   YKD +EC +F   +C +G C NT   + C C  G   D  +  C D+DEC+ 
Sbjct: 1415 SSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ- 1473

Query: 1035 SPDLCGQGTCVNTPGSFEC-------------ECFPGYESGFMLMKNCMDVDEC---ARD 1078
             P  C  G CVNT GS+ C              C    ES   + +  +  D C     D
Sbjct: 1474 DPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSD 1533

Query: 1079 PLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC--EDIDE----CSL--SDGLCPHGQCV 1130
              +C            +C C  G     +   C  +D D+    C++  +    P+G+  
Sbjct: 1534 EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDA 1593

Query: 1131 NVIGAFQCSCHAGFQSTPDR----QGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYS 1186
             V  + Q +  A      DR       +   EC + NG  +  C+  +  Y C C  GY 
Sbjct: 1594 LVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYH 1653

Query: 1187 LMPDGRACADVDECEE-NPR--VCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVD 1240
            L      C DV+EC+E N R  +C    C N  G ++CLC  G++ +     C  ++
Sbjct: 1654 LDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score =  440 bits (1132), Expect = e-123
 Identities = 288/889 (32%), Positives = 396/889 (44%), Gaps = 154/889 (17%)

Query: 869  DVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGV 928
            ++NEC   P +C  G C+N    + C C EG       R CVD+           DEC  
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDI-----------DECTQ 922

Query: 929  TLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVN 988
                        CS G         C + E   F  +CP G   AS +  +      DV+
Sbjct: 923  VQH--------LCSQGR--------CENTEG-SFLCICPAGF-MASEEGTN----CIDVD 960

Query: 989  ECKVFPGLCTHGTCRNTVGSFHCA-CAGGFALDAQERNCTDIDECRISPDLCGQGTCVNT 1047
            EC + P +C  G C NTVG+F C  C  G+ +  Q   C DIDEC ++P  C    CVN+
Sbjct: 961  EC-LRPDVCGEGHCVNTVGAFRCEYCDSGYRM-TQRGRCEDIDEC-LNPSTCPDEQCVNS 1017

Query: 1048 PGSFEC----ECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHE 1103
            PGS++C    E F G+         C+DVDEC  +P +C  G C+N +GSY C C  G+ 
Sbjct: 1018 PGSYQCVPCTEGFRGWNG------QCLDVDECL-EPNVCANGDCSNLEGSYMCSCHKGYT 1070

Query: 1104 LTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQN 1163
             T     C DIDEC   + LC +GQC N  G+F+C+C  G+Q +  +  C DI+EC+ ++
Sbjct: 1071 RTPDHKHCRDIDECQQGN-LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRH 1129

Query: 1164 GGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLC 1223
                  C NTEGS++C C QGY     G  C D++EC E+  VC +G C N  G + C C
Sbjct: 1130 LCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTC 1189

Query: 1224 YDGFMATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVCHCQLGYMVRKGATGCSDVD 1282
             DGF    D +TC D++EC+ +P +C   G+C NT+GSF C CQ G+ +      C D+D
Sbjct: 1190 PDGFQLD-DNKTCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDID 1247

Query: 1283 ECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG--DGFECHDLDECVSQEHRCSPRGDCLN 1340
            EC V    CDSH  C N  GSF C C  G+    DG  C D++EC      C     C N
Sbjct: 1248 EC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG-EAFCEN 1305

Query: 1341 VPGSYRCTC---RQGFAGDGFFC----------------EDRDECAENVD---LCDNGQ- 1377
            V GS+ C C    Q ++     C                E++ EC  N++   LCDN   
Sbjct: 1306 VEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLA 1365

Query: 1378 --------CLNAPGGYRCECEM-------------------GFDPTEDHRA------CQD 1404
                    C  +  G+   CE+                   GF P  +  +       +D
Sbjct: 1366 PNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1425

Query: 1405 VDECAQ--GNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCIN 1462
             DEC      +C  G C N    + C C  G   D     C D++EC DP +CI+G C+N
Sbjct: 1426 ADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVN 1485

Query: 1463 TPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHD---------RGDSGISCSAEIGVG 1513
            T GSY C C     L+ S   C+     N  +E  D           D  +     +G  
Sbjct: 1486 TEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQ 1545

Query: 1514 VTRASCCCSLGRAWGNPCELCPMANTTEYRTLC---------PGG--------EGFQPNR 1556
             T   CCC  G AWG  C LCP+ ++ +Y  LC         P G        E + P  
Sbjct: 1546 TTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEA 1605

Query: 1557 ITVILED----------IDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI 1606
                ++D           +EC  L G C+ G CV     + C+C  GYHL      C D+
Sbjct: 1606 DPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDV 1664

Query: 1607 DEC---STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSV 1652
            +EC   +    +C    C NT G+Y C+C   Y+  +  N C  +  ++
Sbjct: 1665 NECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1713



 Score =  432 bits (1110), Expect = e-120
 Identities = 277/868 (31%), Positives = 405/868 (46%), Gaps = 121/868 (13%)

Query: 1807 NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP--CGNGTCKNI 1864
            NEC   P++C  G C++    Y C+C+ G++ S  Q  C+DIDEC +    C  G C+N 
Sbjct: 876  NECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENT 935

Query: 1865 IGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHC-LCQDGFELTA 1922
             GS+ C+C  GF+ +  G +C+D DEC  L   VC  GHC+NT G+F C  C  G+ +T 
Sbjct: 936  EGSFLCICPAGFMASEEGTNCIDVDEC--LRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993

Query: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI-CPPGFQVQSDHCIDIDECSEEPNLCL 1981
             G+ C D +ECL+   TC    C N  GS++C+ C  GF+  +  C+D+DEC E PN+C 
Sbjct: 994  RGR-CEDIDECLN-PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLE-PNVCA 1050

Query: 1982 FGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKT-RCC 2040
             G C+N  GS+ C C  G+  + +   C D  +         G+C      NT  + RC 
Sbjct: 1051 NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCK-----NTEGSFRCT 1105

Query: 2041 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2100
            C    G+G+         + SAA                D  ED++EC ++  +C +G C
Sbjct: 1106 C----GQGY---------QLSAA---------------KDQCEDIDEC-QHRHLCAHGQC 1136

Query: 2101 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP-CGQGTCTNVIGGFECACADGFEPG 2159
             NT+GSF+C C  GY     G +C D +EC      C +G C N  G ++C C DGF+  
Sbjct: 1137 RNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 1196

Query: 2160 LMMTCEDIDECSLNPLLCAFR--CHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
               TC+DI+EC  +P LC  +  C NTEGS+ C C  G+++  DG  C D+DEC +    
Sbjct: 1197 DNKTCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTV- 1254

Query: 2218 CHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRC 2277
            C + G  C N  G+F C+C  G +  P  G+GC D NEC     +C    C N  GSF C
Sbjct: 1255 CDSHGF-CDNTAGSFRCLCYQGFQA-PQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC 1312

Query: 2278 DC-DEGFQPSPTLTECHDIRQGPCFAEVLQ---------------TMCRSLSSSSEAVTR 2321
             C DE  + SP   +C          +V Q               ++C ++ + +  VT+
Sbjct: 1313 VCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN--VTK 1370

Query: 2322 AECCCGGGRGWGPRCEL--CPLPGTSAYRKLCPHGSGYTAEG-----------RDVDECR 2368
             ECCC  G GWG  CE+  CP+ GT+ + ++CP G G+   G           +D DEC 
Sbjct: 1371 QECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECL 1430

Query: 2369 MLAH-LCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSF 2427
            +    +C +G C+N+   + C+C+ G   D     C DMDEC          C NT+GS+
Sbjct: 1431 LFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSY 1490

Query: 2428 LCSCPRGYLLEEDGRTC-------KDLDECTSRQHNC------QFLCVN-TVGAFT---- 2469
             C C    +L+   + C       + ++E    Q  C      +++C    VG  T    
Sbjct: 1491 NCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTE 1550

Query: 2470 CRCPPGFTQHHQACF----DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHG 2525
            C C  G     Q       D+D+  AQ       G           +  + +T  +  + 
Sbjct: 1551 CCCLYGEAWGMQCALCPLKDSDD-YAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYF 1609

Query: 2526 CED----------VNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENEC-- 2572
             +D            EC   + C++G C     GY C C  G+   +    CVD NEC  
Sbjct: 1610 IQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDE 1669

Query: 2573 -ALSPPTCGSASCRNTLGGFRCVCPSGF 2599
                   C +A C NT G ++C+C  G+
Sbjct: 1670 LNNRMSLCKNAKCINTDGSYKCLCLPGY 1697



 Score =  408 bits (1048), Expect = e-113
 Identities = 276/844 (32%), Positives = 382/844 (45%), Gaps = 104/844 (12%)

Query: 1530 PCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCE 1589
            P E+ P A+T+         +   P ++T    +I+EC   P +C  G C+N    + C 
Sbjct: 851  PVEVAPEASTSS------ASQVIAPTQVT----EINECTVNPDICGAGHCINLPVRYTCI 900

Query: 1590 CPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMD-- 1647
            C  GY  SE  R C DIDEC+    +C  G C NT G++ C+CPA ++    G NC+D  
Sbjct: 901  CYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVD 960

Query: 1648 --MRKSVCFRHYNGTCQNEL-AFNVTRKMCCCSYNIGQAWN-RPCEACPTPIS-PDYQIL 1702
              +R  VC     G C N + AF    + C   Y + Q       + C  P + PD Q  
Sbjct: 961  ECLRPDVCGE---GHCVNTVGAFRC--EYCDSGYRMTQRGRCEDIDECLNPSTCPDEQ-- 1013

Query: 1703 CGNQAPGFLTDIH--------TGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNY 1754
            C N +PG    +          G+ LD+DEC E P +CANG C N  GS+ C C  G+  
Sbjct: 1014 CVN-SPGSYQCVPCTEGFRGWNGQCLDVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTR 1071

Query: 1755 NSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG-GACVGRNECREIP 1813
                  C D+DEC  ++     N  C N  GS+RC C +GY+LS     C   +EC+   
Sbjct: 1072 TPDHKHCRDIDEC--QQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH-R 1128

Query: 1814 NVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCL 1871
            ++C+HG C +TEGS+ C+C +G++AS     C DI+EC  D+  C  G C N  GSY+C 
Sbjct: 1129 HLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCT 1188

Query: 1872 CFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
            C  GF +  N  C D +EC    G     G CLNT GSFHC+CQ GF ++ADG+ C D +
Sbjct: 1189 CPDGFQLDDNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDID 1247

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989
            EC++       G C N  GSFRC+C  GFQ   D   C+D++EC     +C    C N  
Sbjct: 1248 ECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVE 1307

Query: 1990 GSFQCLCP----------------PGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFN 2033
            GSF C+C                     L  +  +  + ++   +   +A  C    A N
Sbjct: 1308 GSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN 1367

Query: 2034 TTKTRCCCSKRPGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE-------D 2084
             TK  CCC+   G GWGD CE+  CP  G+A F E+CP G G VP  + S E       D
Sbjct: 1368 VTKQECCCTS--GAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1425

Query: 2085 VNEC-AENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTN 2143
             +EC      +C NG C+NT   + C C  G   D   + C D DEC     C  G C N
Sbjct: 1426 ADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVN 1485

Query: 2144 VIGGFECACA-----DGFEPGLMMTC---EDIDECSLNPLLC------AFRCH----NTE 2185
              G + C C      D  E   +      E I+E  +   LC       + C       +
Sbjct: 1486 TEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQ 1545

Query: 2186 GSYL-CTCPAGYTLREDGAMC--RDVDECADGQQDCH-----ARGMECKNLIGTFACVCP 2237
             +Y  C C  G       A+C  +D D+ A   Q C+      R    ++ +  F+    
Sbjct: 1546 TTYTECCCLYGEAWGMQCALCPLKDSDDYA---QLCNIPVTGRRQPYGRDALVDFSEQYT 1602

Query: 2238 PGMRPLPGSGEGCTDDNECHAQP----DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECH 2293
            P   P            E  A+     + C NGRCV     + CDC +G+        C 
Sbjct: 1603 PEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCV 1662

Query: 2294 DIRQ 2297
            D+ +
Sbjct: 1663 DVNE 1666



 Score =  394 bits (1012), Expect = e-109
 Identities = 337/1199 (28%), Positives = 461/1199 (38%), Gaps = 298/1199 (24%)

Query: 90   CGE---GFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLC-QKGYTGTV 145
            CG+   G   Q + C    GT+  S G ++   C       G  +   CL   K    T 
Sbjct: 568  CGKALPGLSKQEDCC----GTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTF 623

Query: 146  CG-------QPICDRG-CHNGGRCIGPNRCACVYGFMGPQ-----CERD-----YRTGPC 187
            C        Q +C  G C N    +G  RC C  GF GP      C  D        GPC
Sbjct: 624  CQDINECQLQGVCPNGECLN---TMGSYRCTCKIGF-GPDPTFSSCVPDPPVISEEKGPC 679

Query: 188  FGQVGP-EGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQ 246
            +  V     C H L+ +  TK LCC +VG+AWG  CE CP          +P   T A +
Sbjct: 680  YRLVSSGRQCMHPLS-VHLTKQLCCCSVGKAWGPHCEKCP----------LPG--TAAFK 726

Query: 247  DVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR----AGACFSVLFGG 302
            ++         C GG    + G  H R P+ H +       +       A +        
Sbjct: 727  EI---------CPGGMGYTVSG-VHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPA 776

Query: 303  RCAGDLAGHYTRRQCCCDRGRCWAAGP---VPELCPPRGSNEFQQLCAQRLPLLPGHPGL 359
            +     A  ++R             GP    PE+       E   L  ++  L PG P L
Sbjct: 777  KEEPVEALTFSREH-----------GPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQL 825

Query: 360  FPGLL---------GFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTID 410
             PG+          G       PP+ P  + P  S +     + P        T    I+
Sbjct: 826  SPGISTIHLHPQFPGIVIEKTSPPV-PVEVAPEASTSSASQVIAP--------TQVTEIN 876

Query: 411  ICRHFTNLCLNGRCLPTPSSYRCECNVGYT-QDVRGECIDVDECTSSP--CHHGDCVNIP 467
             C    ++C  G C+  P  Y C C  GY   + + +C+D+DECT     C  G C N  
Sbjct: 877  ECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTE 936

Query: 468  GTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQC-VCNAGFELSPDG 526
            G++ C C  GF A+     C+DVDEC+    +C  G CVNT G+F+C  C++G+ ++  G
Sbjct: 937  GSFLCICPAGFMASEEGTNCIDVDECL-RPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRG 995

Query: 527  K---------------------------------------NCVDHNECATSTMCVNGVCL 547
            +                                        C+D +EC    +C NG C 
Sbjct: 996  RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCS 1055

Query: 548  NEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTD 607
            N +GS+ C C  G+   P   +C DIDECQ   +CVNG C NTEGSFRC C  G  +   
Sbjct: 1056 NLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAA 1115

Query: 608  GRVCVD---THVRSTCYGAIEKGSCARPFPGTVTKSECCC--ANPDHGFGEPCQLCPAKD 662
               C D      R  C      G C      T    +C C       G G+ C+     +
Sbjct: 1116 KDQCEDIDECQHRHLC----AHGQCR----NTEGSFQCVCDQGYRASGLGDHCE--DINE 1165

Query: 663  SAEFQALCSSGLGITTDG------------------RDINECALDPEVCA-NGVCENLRG 703
              E +++C  G  I T G                  +DINEC   P +C   G C N  G
Sbjct: 1166 CLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE-HPGLCGPQGECLNTEG 1224

Query: 704  SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763
            S+ CVC  G+   A G+ C D+DEC  N++   +G+C N+ GS+ C C  GF   QD + 
Sbjct: 1225 SFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQG 1284

Query: 764  CKDVDEC--LSSPCVSGVCRNLAGSYTCKCG-PGSRLDPSGTFCLDSTKGTCWL-----K 815
            C DV+EC  LS  C    C N+ GS+ C C        P    C   T     +     K
Sbjct: 1285 CVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPK 1344

Query: 816  IQESRCEVNLQGASL----------RSECCATLGAAWGSPCERCEIDPACARGFARMT-- 863
             ++  C  NL  ASL          + ECC T GA WG   + CEI P    G A  T  
Sbjct: 1345 EEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWG---DNCEIFPCPVLGTAEFTEM 1401

Query: 864  ------------------GVTCDDVNECESF----------------------------- 876
                              G    D +EC  F                             
Sbjct: 1402 CPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDP 1461

Query: 877  -------------PGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV------------D 911
                         P  C +G+CVNT GS+ C C   ++LDAS + C+            D
Sbjct: 1462 VKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETD 1521

Query: 912  VRLEPCFLRW-DEDECGVTLPGKY-RMDVCCCSIGAVWGVECEACPDPESLEFASLC--- 966
            V  + C+    DE  C   L GK      CCC  G  WG++C  CP  +S ++A LC   
Sbjct: 1522 VYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIP 1581

Query: 967  ------PRG----LGFASRDFLSGRPFY-----------KDVNECKVFPGLCTHGTCRNT 1005
                  P G    + F+ +      P++               EC +  G C +G C   
Sbjct: 1582 VTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRV 1640

Query: 1006 VGSFHCACAGGFALDAQERNCTDIDEC-----RISPDLCGQGTCVNTPGSFECECFPGY 1059
               + C C  G+ LD  +  C D++EC     R+S  LC    C+NT GS++C C PGY
Sbjct: 1641 QEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMS--LCKNAKCINTDGSYKCLCLPGY 1697



 Score =  394 bits (1012), Expect = e-109
 Identities = 364/1244 (29%), Positives = 491/1244 (39%), Gaps = 248/1244 (19%)

Query: 1308 CLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDE 1365
            CLPG+  V + F C D++EC  Q     P G+CLN  GSYRCTC+ GF  D  F      
Sbjct: 612  CLPGYKRVNNTF-CQDINEC--QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTF----SS 664

Query: 1366 CAENVDLC--DNGQCLN-APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG-SCEN 1421
            C  +  +   + G C      G +C       P   H   Q +  C+ G   A+G  CE 
Sbjct: 665  CVPDPPVISEEKGPCYRLVSSGRQC-----MHPLSVHLTKQ-LCCCSVGK--AWGPHCEK 716

Query: 1422 LP----GMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477
             P      F+ IC GG                      ++GV    P  +       F +
Sbjct: 717  CPLPGTAAFKEICPGGMGY------------------TVSGVHRRRPIHHHVGKGPVF-V 757

Query: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
             P     V        L   +     ++ S E G GV       +       P E    +
Sbjct: 758  KPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATA-------PPEKEIPS 810

Query: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLS 1597
               E   L PG     P   T+ L       + PG+        T      E  P    S
Sbjct: 811  LDQEKTKLEPGQPQLSPGISTIHLH-----PQFPGIV----IEKTSPPVPVEVAPEASTS 861

Query: 1598 EHTRICEDIDECSTHSGICGPGTC-----YNTLGNYTCVCPAEYLQVNGGNNCMDMRKSV 1652
              +++         +     P  C      N    YTC+C   Y        C+D+ +  
Sbjct: 862  SASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECT 921

Query: 1653 CFRHY--NGTCQN-ELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPG 1709
              +H    G C+N E +F     +C C                                G
Sbjct: 922  QVQHLCSQGRCENTEGSF-----LCIC------------------------------PAG 946

Query: 1710 FLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCE-CPAGFNYNSILLACEDVDECG 1768
            F+        +D+DEC   P +C  G C+N +G+FRCE C +G+        CED+DEC 
Sbjct: 947  FMASEEGTNCIDVDECLR-PDVCGEGHCVNTVGAFRCEYCDSGYRMTQ-RGRCEDIDEC- 1003

Query: 1769 SRESPCQQNADCINIPGSYRC-KCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGS 1827
               S C  +  C+N PGSY+C  CT G++    G C+  +EC E PNVC++GDC + EGS
Sbjct: 1004 LNPSTC-PDEQCVNSPGSYQCVPCTEGFR-GWNGQCLDVDECLE-PNVCANGDCSNLEGS 1060

Query: 1828 YMCLCHRGFQASADQTLCMDIDECDR-QPCGNGTCKNIIGSYNCLCFPGFVVTHNGD-CV 1885
            YMC CH+G+  + D   C DIDEC +   C NG CKN  GS+ C C  G+ ++   D C 
Sbjct: 1061 YMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE 1120

Query: 1886 DFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTC 1945
            D DEC      +C  G C NT GSF C+C  G+  +  G +C D NECL     C  G C
Sbjct: 1121 DIDECQH--RHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC 1178

Query: 1946 QNLEGSFRCICPPGFQVQSDH-CIDIDECSEEPNLC-LFGTCTNSPGSFQCLCPPGFVLS 2003
             N  GS+ C CP GFQ+  +  C DI+EC E P LC   G C N+ GSF C+C  GF +S
Sbjct: 1179 INTAGSYDCTCPDGFQLDDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSIS 1237

Query: 2004 DNGHRCFDTRQSFCFTRFEA-GKCSVPKAFNTTKT-RCCCSKRPGEGWGDPCELCPQEGS 2061
             +G  C D  +    T  ++ G C      NT  + RC C                 +G 
Sbjct: 1238 ADGRTCEDIDECVNNTVCDSHGFCD-----NTAGSFRCLC----------------YQGF 1276

Query: 2062 AAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECP--------- 2112
             A Q+    G G V        DVNEC    GVC    C N +GSF C C          
Sbjct: 1277 QAPQD----GQGCV--------DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPM 1324

Query: 2113 FGYSLDFTGINC-VDTD-------ECSVGHPCGQGTCTNVIG----GFECACADGFEPGL 2160
             G     T  +  VD D       EC   +      C NV+       EC C  G   G 
Sbjct: 1325 TGQCRSRTSTDLDVDVDQPKEEKKECYY-NLNDASLCDNVLAPNVTKQECCCTSGAGWG- 1382

Query: 2161 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCT-----CPAGYTLRE-DGAMCRDVDEC-AD 2213
                   D C + P         TE   +C       PAG +  E  G   +D DEC   
Sbjct: 1383 -------DNCEIFPCPVLGTAEFTE---MCPKGKGFVPAGESSSEAGGENYKDADECLLF 1432

Query: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAG 2273
            GQ+ C  +   C N    + C C  G    P   + C D +EC   P  C++G+CVNT G
Sbjct: 1433 GQEIC--KNGFCLNTRPGYECYCKQGTYYDPVKLQ-CFDMDECQ-DPSSCIDGQCVNTEG 1488

Query: 2274 SFRCDCDEGFQPSPTLTEC------------HDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
            S+ C C        +   C             D+ Q  C+  +      S     +  T 
Sbjct: 1489 SYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTY 1548

Query: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLC---------PHG--------SGYTAEG--- 2361
             ECCC  G  WG +C LCPL  +  Y +LC         P+G          YT E    
Sbjct: 1549 TECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPY 1608

Query: 2362 ------------RDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
                           +EC +L + C +G C+     + C C  GY  D    TC+D++EC
Sbjct: 1609 FIQDRFLNSFEELQAEECGIL-NGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC 1667

Query: 2410 SQVPKPCTFLCKNTK-----GSFLCSCPRGYLLEEDGRTCKDLD 2448
             ++    + LCKN K     GS+ C C  GY+  +    C  L+
Sbjct: 1668 DELNNRMS-LCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score =  367 bits (942), Expect = e-101
 Identities = 337/1194 (28%), Positives = 476/1194 (39%), Gaps = 222/1194 (18%)

Query: 529  CVDHNECATSTMCVNGVCLNEDGSFSCLCK------------------------PGFLLA 564
            C D NEC    +C NG CLN  GS+ C CK                        P + L 
Sbjct: 624  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLV 683

Query: 565  PGGHYCMDIDE--------CQTPGICVNGHCTNTE----GSFRCQCLGGLAVGTDG---R 609
              G  CM            C + G     HC         +F+  C GG+     G   R
Sbjct: 684  SSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRR 743

Query: 610  VCVDTHV-------RSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFG--EPCQLCPA 660
              +  HV       +      + K +   P P      E    + +HG G  EP ++  A
Sbjct: 744  RPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEP-EVATA 802

Query: 661  KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRG------SYRCVCNLGYE 714
                E  +L      +     +  +  L P +    +     G      S      +  E
Sbjct: 803  PPEKEIPSLDQEKTKL-----EPGQPQLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPE 857

Query: 715  AGASGKD-------CTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV 767
            A  S           T+++EC +N  +C  G C N P  Y+C C  G+ F +    C D+
Sbjct: 858  ASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDI 917

Query: 768  DEC--LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQES-RCEVN 824
            DEC  +   C  G C N  GS+ C C  G          + S +GT  + + E  R +V 
Sbjct: 918  DECTQVQHLCSQGRCENTEGSFLCICPAGF---------MASEEGTNCIDVDECLRPDVC 968

Query: 825  LQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGR 884
             +G      C  T+GA       RCE    C  G+       C+D++EC + P  CP+ +
Sbjct: 969  GEG-----HCVNTVGAF------RCEY---CDSGYRMTQRGRCEDIDECLN-PSTCPDEQ 1013

Query: 885  CVNTAGSFRC-ECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943
            CVN+ GS++C  C EG         C+DV           DEC         ++   C+ 
Sbjct: 1014 CVNSPGSYQCVPCTEGFR--GWNGQCLDV-----------DEC---------LEPNVCAN 1051

Query: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCR 1003
            G           D  +LE + +C    G+            +D++EC+    LC +G C+
Sbjct: 1052 G-----------DCSNLEGSYMCSCHKGYTRTP---DHKHCRDIDECQQ-GNLCVNGQCK 1096

Query: 1004 NTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGF 1063
            NT GSF C C  G+ L A +  C DIDEC+    LC  G C NT GSF+C C  GY +  
Sbjct: 1097 NTEGSFRCTCGQGYQLSAAKDQCEDIDECQ-HRHLCAHGQCRNTEGSFQCVCDQGYRASG 1155

Query: 1064 MLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL 1123
             L  +C D++EC  D  +C+ G C NT GSY C CP G +L    T C+DI+EC    GL
Sbjct: 1156 -LGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKT-CQDINECE-HPGL 1212

Query: 1124 C-PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVH--CINTEGSYRCS 1180
            C P G+C+N  G+F C C  GF  + D + C DI+EC V N  CD H  C NT GS+RC 
Sbjct: 1213 CGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCL 1271

Query: 1181 CGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMA-TPDMRTC--- 1236
            C QG+    DG+ C DV+ECE    VC +  C N+ G   C+C D     +P    C   
Sbjct: 1272 CYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSR 1331

Query: 1237 ------VDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHN 1290
                  VDVD+       C +    N   + +C   L   V K    C+        G N
Sbjct: 1332 TSTDLDVDVDQPKEEKKECYY----NLNDASLCDNVLAPNVTKQECCCT---SGAGWGDN 1384

Query: 1291 CDSHASCLNIPGSFSCRCLPG----------WVGDGFECHDLDECVSQEHRCSPRGDCLN 1340
            C+     +     F+  C  G              G    D DEC+         G CLN
Sbjct: 1385 CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLN 1444

Query: 1341 VPGSYRCTCRQGFAGD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC--EMGFDPT 1396
                Y C C+QG   D     C D DEC ++   C +GQC+N  G Y C C   M  D +
Sbjct: 1445 TRPGYECYCKQGTYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDAS 1503

Query: 1397 EDH--RACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVN 1454
            E    R  +  ++  + ++      E+L   +  +C+         G  T   EC     
Sbjct: 1504 EKRCIRPAESNEQIEETDVYQDLCWEHLSDEY--VCSRPLV-----GKQTTYTECC---- 1552

Query: 1455 CING-----VCINTP------GSYLCSCPQDFELNPSGVGCV-------DTRAGNCFLET 1496
            C+ G      C   P       + LC+ P      P G   +          A   F++ 
Sbjct: 1553 CLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQ- 1611

Query: 1497 HDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNR 1556
                D  ++   E+     +A  C  L     N CE        E  T C   +G+  + 
Sbjct: 1612 ----DRFLNSFEEL-----QAEECGIL-----NGCENGRCVRVQEGYT-CDCFDGYHLDT 1656

Query: 1557 ITVILEDIDECQEL---PGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607
              +   D++EC EL     LC+   C+NT GS++C C PGY  S+    C  ++
Sbjct: 1657 AKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score =  365 bits (937), Expect = e-100
 Identities = 279/946 (29%), Positives = 385/946 (40%), Gaps = 195/946 (20%)

Query: 1364 DECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQ-GNLCAFGSCENL 1422
            +EC  N D+C  G C+N P  Y C C  G+  +E  R C D+DEC Q  +LC+ G CEN 
Sbjct: 876  NECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENT 935

Query: 1423 PGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCS-CPQDFELNPSG 1481
             G F CIC  G+     G NC D++EC  P  C  G C+NT G++ C  C   + +    
Sbjct: 936  EGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM---- 991

Query: 1482 VGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC--CSLG-RAWGNPCELCPMAN 1538
                 T+ G C  E  D   +  +C  E  V    +  C  C+ G R W   C       
Sbjct: 992  -----TQRGRC--EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCL------ 1038

Query: 1539 TTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSE 1598
                                    D+DEC E P +C  GDC N  GS+ C C  GY  + 
Sbjct: 1039 ------------------------DVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTP 1073

Query: 1599 HTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYN 1658
              + C DIDEC     +C  G C NT G++ C C   Y      + C D+ +        
Sbjct: 1074 DHKHCRDIDECQ-QGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDE-------- 1124

Query: 1659 GTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILC--GNQAPGFLTDIHT 1716
              CQ+       R +C      GQ  N             +Q +C  G +A G       
Sbjct: 1125 --CQH-------RHLCAH----GQCRNT---------EGSFQCVCDQGYRASGLGDHCE- 1161

Query: 1717 GKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESP--C 1774
                DI+EC E  ++C  G CIN  GS+ C CP GF  +     C+D++EC   E P  C
Sbjct: 1162 ----DINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK-TCQDINEC---EHPGLC 1213

Query: 1775 QQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCLCH 1833
                +C+N  GS+ C C +G+ +S  G  C   +EC       SHG C +T GS+ CLC+
Sbjct: 1214 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 1273

Query: 1834 RGFQASADQTLCMDIDECDRQP--CGNGTCKNIIGSYNCLCFPGF--VVTHNGDC----- 1884
            +GFQA  D   C+D++EC+     CG   C+N+ GS+ C+C           G C     
Sbjct: 1274 QGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTS 1333

Query: 1885 ----VDFDE-----------------CTTLVGQVCRFGHCLNTAGS--------FHCLCQ 1915
                VD D+                 C  ++        C  T+G+        F C   
Sbjct: 1334 TDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVL 1393

Query: 1916 DGFELT------------------ADGKNCVDTNECLSLAGT-CLPGTCQNLEGSFRCIC 1956
               E T                  A G+N  D +ECL      C  G C N    + C C
Sbjct: 1394 GTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYC 1453

Query: 1957 PPG--FQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCF---- 2010
              G  +      C D+DEC ++P+ C+ G C N+ GS+ C C    VL  +  RC     
Sbjct: 1454 KQGTYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE 1512

Query: 2011 --------DTRQSFCFTRF-EAGKCSVPKAFN-TTKTRCCCSKRPGEGWGDPCELCPQEG 2060
                    D  Q  C+    +   CS P     TT T CCC    GE WG  C LCP + 
Sbjct: 1513 SNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY--GEAWGMQCALCPLKD 1570

Query: 2061 SAAFQELC--PFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD 2118
            S  + +LC  P      P   D+  D +E                   +  E    +  D
Sbjct: 1571 SDDYAQLCNIPVTGRRQPYGRDALVDFSE------------------QYTPEADPYFIQD 1612

Query: 2119 --FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFE-PGLMMTCEDIDECS-LNP 2174
                    +  +EC + + C  G C  V  G+ C C DG+      MTC D++EC  LN 
Sbjct: 1613 RFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNN 1672

Query: 2175 L--LCA-FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
               LC   +C NT+GSY C C  GY   +    C  ++   + ++D
Sbjct: 1673 RMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKD 1718



 Score =  296 bits (758), Expect = 2e-79
 Identities = 202/621 (32%), Positives = 269/621 (43%), Gaps = 110/621 (17%)

Query: 2084 DVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTN 2143
            D++EC +   +C+ G C NT+GSF C CP G+     G NC+D DEC     CG+G C N
Sbjct: 916  DIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVN 975

Query: 2144 VIGGFECA-CADGFEPGLMMTCEDIDECSLNPLLCA-FRCHNTEGSYLCT-CPAGYTLRE 2200
             +G F C  C  G+       CEDIDEC LNP  C   +C N+ GSY C  C  G+  R 
Sbjct: 976  TVGAFRCEYCDSGYRMTQRGRCEDIDEC-LNPSTCPDEQCVNSPGSYQCVPCTEGF--RG 1032

Query: 2201 DGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQP 2260
                C DVDEC   + +  A G +C NL G++ C C  G    P   + C D +EC  Q 
Sbjct: 1033 WNGQCLDVDECL--EPNVCANG-DCSNLEGSYMCSCHKGYTRTP-DHKHCRDIDECQ-QG 1087

Query: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT 2320
            +LCVNG+C NT GSFRC C +G+Q S    +C DI +           CR+   S     
Sbjct: 1088 NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGS----- 1142

Query: 2321 RAECCCGGG---RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG 2377
              +C C  G    G G  CE                         D++EC     +C  G
Sbjct: 1143 -FQCVCDQGYRASGLGDHCE-------------------------DINECLEDKSVCQRG 1176

Query: 2378 ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPC--TFLCKNTKGSFLCSCPRGY 2435
            +CIN+ GS+ C C  G+  D    TC D++EC   P  C     C NT+GSF C C +G+
Sbjct: 1177 DCINTAGSYDCTCPDGFQLDDN-KTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGF 1234

Query: 2436 LLEEDGRTCKDLDECTSRQ-HNCQFLCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQ 2492
             +  DGRTC+D+DEC +    +    C NT G+F C C  GF   Q  Q C D +EC   
Sbjct: 1235 SISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELL 1294

Query: 2493 PGPCGAHGHCHNTPGSFRCEC---HQGFTLVSSG------------------------HG 2525
             G CG    C N  GSF C C   +Q ++ ++                          + 
Sbjct: 1295 SGVCG-EAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYN 1353

Query: 2526 CEDVNECD---GPHRCQHGCQNQLG---GYRCS---------------CPQG-------- 2556
              D + CD    P+  +  C    G   G  C                CP+G        
Sbjct: 1354 LNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGE 1413

Query: 2557 FTQHSQWAQCVDENECAL-SPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECA 2615
             +  +      D +EC L     C +  C NT  G+ C C  G  +D     C ++DEC 
Sbjct: 1414 SSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ 1473

Query: 2616 GRRGPCSYSCANTPGGFLCGC 2636
                     C NT G + C C
Sbjct: 1474 DPSSCIDGQCVNTEGSYNCFC 1494



 Score =  228 bits (580), Expect = 8e-59
 Identities = 141/407 (34%), Positives = 189/407 (46%), Gaps = 50/407 (12%)

Query: 2251 TDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCR 2310
            T+ NEC   PD+C  G C+N    + C C EG++ S    +C DI               
Sbjct: 873  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDI--------------- 917

Query: 2311 SLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGR---DVDEC 2367
                  +  T+ +  C  GR     CE        ++  +CP G   + EG    DVDEC
Sbjct: 918  ------DECTQVQHLCSQGR-----CENTE----GSFLCICPAGFMASEEGTNCIDVDEC 962

Query: 2368 RMLAHLCAHGECINSLGSFRC-HCQAGYTPDATATTCLDMDECSQVPKPCTF-LCKNTKG 2425
             +   +C  G C+N++G+FRC +C +GY        C D+DEC   P  C    C N+ G
Sbjct: 963  -LRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGR-CEDIDECLN-PSTCPDEQCVNSPG 1019

Query: 2426 SFLC-SCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ--HHQA 2482
            S+ C  C  G+        C D+DEC          C N  G++ C C  G+T+   H+ 
Sbjct: 1020 SYQCVPCTEGF--RGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKH 1077

Query: 2483 CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG- 2541
            C D DEC  Q G    +G C NT GSFRC C QG+ L ++   CED++EC   H C HG 
Sbjct: 1078 CRDIDEC--QQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQ 1135

Query: 2542 CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDF 2601
            C+N  G ++C C QG+        C D NEC      C    C NT G + C CP GF  
Sbjct: 1136 CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL 1195

Query: 2602 DQALGGCQEVDECA--GRRGPCSYSCANTPGGFLCGCPQGYFRAGQG 2646
            D     CQ+++EC   G  GP    C NT G F C C QG+  +  G
Sbjct: 1196 DDNKT-CQDINECEHPGLCGPQG-ECLNTEGSFHCVCQQGFSISADG 1240



 Score =  211 bits (538), Expect = 6e-54
 Identities = 115/292 (39%), Positives = 152/292 (52%), Gaps = 11/292 (3%)

Query: 2363 DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF-LCK 2421
            +++EC +   +C  G CIN    + C C  GY        C+D+DEC+QV   C+   C+
Sbjct: 874  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 933

Query: 2422 NTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCR-CPPGFTQHH 2480
            NT+GSFLC CP G++  E+G  C D+DEC       +  CVNTVGAF C  C  G+    
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993

Query: 2481 QA-CFDNDECSAQPGPCGAHGHCHNTPGSFRC-ECHQGFTLVSSGHGCEDVNECDGPHRC 2538
            +  C D DEC   P  C     C N+PGS++C  C +GF        C DV+EC  P+ C
Sbjct: 994  RGRCEDIDEC-LNPSTCPDE-QCVNSPGSYQCVPCTEGFR--GWNGQCLDVDECLEPNVC 1049

Query: 2539 QHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPS 2597
             +G C N  G Y CSC +G+T+      C D +EC      C +  C+NT G FRC C  
Sbjct: 1050 ANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN-LCVNGQCKNTEGSFRCTCGQ 1108

Query: 2598 GFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQG-HC 2648
            G+    A   C+++DEC  R       C NT G F C C QGY  +G G HC
Sbjct: 1109 GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHC 1160



 Score =  116 bits (290), Expect = 4e-25
 Identities = 149/644 (23%), Positives = 209/644 (32%), Gaps = 155/644 (24%)

Query: 55   QGPNVCGSRFHAYCCPGWRTFPGRSQCV-VPIC--RRACGEGFCSQPN---LCTCADGTL 108
            Q  N  GS F   C  G++    + QC  +  C  R  C  G C        C C  G  
Sbjct: 1094 QCKNTEGS-FRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGY- 1151

Query: 109  APSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPIC----------DRGCHNG 158
                   R SG    C +   C     +CQ+G      G   C          ++ C + 
Sbjct: 1152 -------RASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDI 1204

Query: 159  GRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCA--TVGR 216
              C  P  C       GPQ E    T   F  V  +G      G  C     C   TV  
Sbjct: 1205 NECEHPGLC-------GPQGEC-LNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCD 1256

Query: 217  AWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRC-P 275
            + G       +    C +GF        C DV+EC+ + G+C    C N+ GSF C C  
Sbjct: 1257 SHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 1316

Query: 276  VGHRLSDSSAAC---------------EDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCD 320
                 S  +  C               ++ +    +++     C   LA + T+++CCC 
Sbjct: 1317 ENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCT 1376

Query: 321  RGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARL 380
             G  W        CP  G+ EF ++C                                  
Sbjct: 1377 SGAGWGDNCEIFPCPVLGTAEFTEMC---------------------------------- 1402

Query: 381  NPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVG-Y 439
             P G   +G    G  +S  G        +       +C NG CL T   Y C C  G Y
Sbjct: 1403 -PKG---KGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTY 1458

Query: 440  TQDVRGECIDVDECTS-SPCHHGDCVNIPGTYHCRCYPGFQATPTRQACV-------DVD 491
               V+ +C D+DEC   S C  G CVN  G+Y+C C        + + C+        ++
Sbjct: 1459 YDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIE 1518

Query: 492  ECIVSGGLC--HLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNG----- 544
            E  V   LC  HL        S + VC+         +  V      T   C+ G     
Sbjct: 1519 ETDVYQDLCWEHL--------SDEYVCS---------RPLVGKQTTYTECCCLYGEAWGM 1561

Query: 545  ---VC-LNEDGSFSCLCK---PGFLLAPGGHYCMDIDECQTP------------------ 579
               +C L +   ++ LC     G     G    +D  E  TP                  
Sbjct: 1562 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1621

Query: 580  -----GI---CVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTH 615
                 GI   C NG C   +  + C C  G  + T    CVD +
Sbjct: 1622 QAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVN 1665



 Score =  101 bits (251), Expect = 1e-20
 Identities = 128/550 (23%), Positives = 176/550 (32%), Gaps = 158/550 (28%)

Query: 57   PNVCGSR---------FHAYCCPGW------RTFPGRSQCVV-PICRRACGEGFCSQPN- 99
            P +CG +         FH  C  G+      RT     +CV   +C      GFC     
Sbjct: 1210 PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCD---SHGFCDNTAG 1266

Query: 100  --LCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHN 157
               C C  G  AP  G          C++   C   S +C + +   V G  +C     N
Sbjct: 1267 SFRCLCYQGFQAPQDGQG--------CVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 1318

Query: 158  G------GRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCC 211
                   G+C              P+ E+      C+  +        +     TK  CC
Sbjct: 1319 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKK----ECYYNLNDASLCDNVLAPNVTKQECC 1374

Query: 212  ATVGRAWGLPCELCPAQ------------------------------------------P 229
             T G  WG  CE+ P                                             
Sbjct: 1375 CTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQ 1434

Query: 230  HPCRRGFIPNIHTG----------------ACQDVDECQAVPGLCQGGSCVNMVGSFHCR 273
              C+ GF  N   G                 C D+DECQ  P  C  G CVN  GS++C 
Sbjct: 1435 EICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCF 1493

Query: 274  CPVGHRLSDSSAAC------------EDYRAGACFSVLFGGR-CAGDLAGHYTR-RQCCC 319
            C     L  S   C             D     C+  L     C+  L G  T   +CCC
Sbjct: 1494 CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCC 1553

Query: 320  DRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPAR 379
              G  W  G    LCP + S+++ QLC   +P+                          R
Sbjct: 1554 LYGEAW--GMQCALCPLKDSDDYAQLC--NIPVT------------------------GR 1585

Query: 380  LNPHGSDA------RGIPSLGPGNSNIGTATLNQTIDICRH---FTNLCLNGRCLPTPSS 430
              P+G DA      +  P   P    I    LN   ++        N C NGRC+     
Sbjct: 1586 RQPYGRDALVDFSEQYTPEADP--YFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEG 1643

Query: 431  YRCECNVGYTQDV-RGECIDVDECTS-----SPCHHGDCVNIPGTYHCRCYPGFQATPTR 484
            Y C+C  GY  D  +  C+DV+EC       S C +  C+N  G+Y C C PG+  +   
Sbjct: 1644 YTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKP 1703

Query: 485  QACVDVDECI 494
              C  ++  +
Sbjct: 1704 NYCTPLNTAL 1713



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 64/237 (27%), Positives = 102/237 (43%), Gaps = 47/237 (19%)

Query: 1487 TRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG-NPCELCPMANTTE-YRT 1544
            T+ G CF ET      G  C   +     +  CC ++G +WG N C+ CP   +   Y  
Sbjct: 554  TQLGRCFQET-----IGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQ 608

Query: 1545 LCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC- 1603
            +     G++    T   +DI+ECQ L G+C  G+C+NT GS++C C  G+        C 
Sbjct: 609  MMECLPGYKRVNNT-FCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666

Query: 1604 EDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQN 1663
             D    S   G C                   Y  V+ G  CM                +
Sbjct: 667  PDPPVISEEKGPC-------------------YRLVSSGRQCM----------------H 691

Query: 1664 ELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPL 1720
             L+ ++T+++CCCS  +G+AW   CE CP P +  ++ +C       ++ +H  +P+
Sbjct: 692  PLSVHLTKQLCCCS--VGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPI 746



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 180/769 (23%), Positives = 246/769 (31%), Gaps = 185/769 (24%)

Query: 68   CCPGWRTFPGR----SQCVVPICRRACGEGFCSQPN---LCTCADG-TLAPSCGVSRGSG 119
            C  G+R + G+     +C+ P     C  G CS      +C+C  G T  P     R   
Sbjct: 1026 CTEGFRGWNGQCLDVDECLEP---NVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDID 1082

Query: 120  CSVSCMNGGTCRGASCLCQKGYTGTVCGQP--------------------ICDRG-CHNG 158
                C  G  C    C   +G     CGQ                     +C  G C N 
Sbjct: 1083 ---ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNT 1139

Query: 159  GRCIGPNRCACVYGF----MGPQCE---------RDYRTGPCFGQVG------PEG---- 195
                G  +C C  G+    +G  CE            + G C    G      P+G    
Sbjct: 1140 E---GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 1196

Query: 196  ----------CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGAC 245
                      C+H   GL   +  C  T G      C         C++GF  +     C
Sbjct: 1197 DNKTCQDINECEHP--GLCGPQGECLNTEG---SFHCV--------CQQGFSISADGRTC 1243

Query: 246  QDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCA 305
            +D+DEC         G C N  GSF C C  G +       C D       S + G    
Sbjct: 1244 EDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFC 1303

Query: 306  GDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLG 365
             ++ G +     C D  + ++  P+   C  R S +        L +    P        
Sbjct: 1304 ENVEGSFLC--VCADENQEYS--PMTGQCRSRTSTD--------LDVDVDQPKEEKKECY 1351

Query: 366  FGSNGMGPPLGPARLNPHGSDARGIPSLGPG---NSNIGTATLNQTIDICRHFTNLCLNG 422
            +  N     L    L P+ +      + G G   N  I    +  T +    FT +C  G
Sbjct: 1352 YNLNDAS--LCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE----FTEMCPKG 1405

Query: 423  R-CLPTPSSYRCECNVGYTQDVRGECI-DVDECT---SSPCHHGDCVNIPGTYHCRCYPG 477
            +  +P   S         + +  GE   D DEC       C +G C+N    Y C C  G
Sbjct: 1406 KGFVPAGES---------SSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1456

Query: 478  FQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECAT 537
                P +  C D+DEC      C  G+CVNTEGS+ C C     L    K C+   E   
Sbjct: 1457 TYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNE 1515

Query: 538  STMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQ 597
                     + E   +  LC           +  D   C  P   V    T TE    C 
Sbjct: 1516 Q--------IEETDVYQDLC---------WEHLSDEYVCSRP--LVGKQTTYTE----CC 1552

Query: 598  CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGT---------VTKSECCCANPD 648
            CL G A G    +C      S  Y  +    C  P  G          V  SE      D
Sbjct: 1553 CLYGEAWGMQCALCPLKD--SDDYAQL----CNIPVTGRRQPYGRDALVDFSEQYTPEAD 1606

Query: 649  HGF-------------GEPCQLCPAKDSAE-------FQALCSSGLGITTDGR---DINE 685
              F              E C +    ++         +   C  G  + T      D+NE
Sbjct: 1607 PYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNE 1666

Query: 686  CAL---DPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALN 731
            C        +C N  C N  GSY+C+C  GY        CT ++  ALN
Sbjct: 1667 CDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN-TALN 1714



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 46/165 (27%), Positives = 67/165 (40%), Gaps = 40/165 (24%)

Query: 1388 ECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDIN 1447
            EC  G+    ++  CQD++EC    +C  G C N  G +RC C  G+  D    +C    
Sbjct: 611  ECLPGYKRV-NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV--- 666

Query: 1448 ECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCS 1507
               DP                                +    G C+        SG  C 
Sbjct: 667  --PDP------------------------------PVISEEKGPCYRLV----SSGRQCM 690

Query: 1508 AEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGF 1552
              + V +T+  CCCS+G+AWG  CE CP+  T  ++ +CPGG G+
Sbjct: 691  HPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGY 735



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 42/127 (33%), Positives = 68/127 (53%), Gaps = 12/127 (9%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGG-GRGWG-PRCELCPL-PGTSAYRKLCPHG 2354
            G CF E + + C     +   +++ E CCG  G  WG  +C+ CP  P    Y ++    
Sbjct: 557  GRCFQETIGSQC---GKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECL 613

Query: 2355 SGYTAEG----RDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCL-DMDEC 2409
             GY        +D++EC+ L  +C +GEC+N++GS+RC C+ G+ PD T ++C+ D    
Sbjct: 614  PGYKRVNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVI 672

Query: 2410 SQVPKPC 2416
            S+   PC
Sbjct: 673  SEEKGPC 679



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 19/108 (17%)

Query: 2565 QCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYS 2624
            Q  + NEC ++P  CG+  C N    + C+C  G+ F +    C ++DEC   +  CS  
Sbjct: 871  QVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQG 930

Query: 2625 -CANTPGGFLCGCPQGYFRA------------------GQGHCVSGLG 2653
             C NT G FLC CP G+  +                  G+GHCV+ +G
Sbjct: 931  RCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVG 978



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 61/219 (27%), Positives = 82/219 (37%), Gaps = 38/219 (17%)

Query: 76   PGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCR---G 132
            PG  QCV       C EGF      C   D  L P+            C NG        
Sbjct: 1018 PGSYQCV------PCTEGFRGWNGQCLDVDECLEPNV-----------CANGDCSNLEGS 1060

Query: 133  ASCLCQKGYTGTVCGQPICDRG-CHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQV 191
              C C KGYT T   +   D   C  G  C+   +C    G     C + Y+      Q 
Sbjct: 1061 YMCSCHKGYTRTPDHKHCRDIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQLSAAKDQC 1119

Query: 192  GP-EGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDE 250
               + CQH+    +C    C  T G      C         C +G+  +     C+D++E
Sbjct: 1120 EDIDECQHRH---LCAHGQCRNTEG---SFQCV--------CDQGYRASGLGDHCEDINE 1165

Query: 251  CQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED 289
            C     +CQ G C+N  GS+ C CP G +L D+   C+D
Sbjct: 1166 CLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK-TCQD 1203



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 5/115 (4%)

Query: 913  RLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGV-ECEACPDPESLEFASLCPRGLG 971
            +L  CF      +CG  LPG  + + CC ++G  WG  +C+ CP   S    +     L 
Sbjct: 555  QLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLP 614

Query: 972  FASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNC 1026
               R       F +D+NEC++  G+C +G C NT+GS+ C C  GF  D    +C
Sbjct: 615  GYKR---VNNTFCQDINECQL-QGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 33/82 (40%), Positives = 38/82 (46%), Gaps = 6/82 (7%)

Query: 54  LQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRAC-GEGFCSQPNLCTCADGTLAPSC 112
           LQG NVCG R    CC GW   PG  +C  P C   C   G C +P LC C  GT   +C
Sbjct: 163 LQGVNVCGGR----CCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKAC 218

Query: 113 GVSRGSGCSVSCMNGGTCRGAS 134
                   S S + GG   GA+
Sbjct: 219 ETIAAQDTS-SPVFGGQSPGAA 239



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 86/370 (23%), Positives = 120/370 (32%), Gaps = 93/370 (25%)

Query: 98  PNLC--TCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGC 155
           P++C  TC  G+   SC   +G+  ++   NG     A  L    +   +C  P     C
Sbjct: 358 PSICKVTCTKGSCQNSC--EKGNTTTLISENG---HAADTLTATNFRVVICHLP-----C 407

Query: 156 HNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQH-QLTGLVCTKALCCATV 214
            NGG+C   ++C C   F G  C+      P  G   P+  QH Q  G    KAL    +
Sbjct: 408 MNGGQCSSRDKCQCPPNFTGKLCQI-----PVHGASVPKLYQHSQQPG----KALGTHVI 458

Query: 215 GRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDEC-------------------QAVP 255
                LP  +   Q    +  F PNI     +   E                    +A P
Sbjct: 459 HSTHTLPLTVTSQQGVKVK--FPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQP 516

Query: 256 GLCQ---GGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHY 312
           G  Q    G  V    + H        +          + G CF    G +C   L G  
Sbjct: 517 GQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLS 576

Query: 313 TRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG 372
            +  CC   G  W      + CP + S        Q +  LPG+                
Sbjct: 577 KQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYN---QMMECLPGY---------------- 616

Query: 373 PPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYR 432
                 R+N                      T  Q I+ C+    +C NG CL T  SYR
Sbjct: 617 -----KRVN---------------------NTFCQDINECQ-LQGVCPNGECLNTMGSYR 649

Query: 433 CECNVGYTQD 442
           C C +G+  D
Sbjct: 650 CTCKIGFGPD 659



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 39/117 (33%), Positives = 57/117 (48%), Gaps = 7/117 (5%)

Query: 2012 TRQSFCFTRFEAGKCSVPKAF-NTTKTRCCCSKRPGEGWG-DPCELCPQEGSA-AFQELC 2068
            T+   CF      +C   KA    +K   CC    G  WG + C+ CP++ S   + ++ 
Sbjct: 554  TQLGRCFQETIGSQCG--KALPGLSKQEDCCGT-VGTSWGFNKCQKCPKKPSYHGYNQMM 610

Query: 2069 PFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCV 2125
                G     +   +D+NEC +  GVC NG C+NT GS+RC C  G+  D T  +CV
Sbjct: 611  ECLPGYKRVNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 5/124 (4%)

Query: 1653 CFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWN-RPCEACPTPISPDYQILCGNQAPGFL 1711
            CF+   G+   +    ++++  CC   +G +W    C+ CP   S           PG+ 
Sbjct: 559  CFQETIGSQCGKALPGLSKQEDCCG-TVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYK 617

Query: 1712 TDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLAC-EDVDECGSR 1770
              ++     DI+EC ++  +C NG C+N +GS+RC C  GF  +    +C  D       
Sbjct: 618  R-VNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEE 675

Query: 1771 ESPC 1774
            + PC
Sbjct: 676  KGPC 679



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 53/202 (26%), Positives = 80/202 (39%), Gaps = 37/202 (18%)

Query: 2464 TVGAFTCRCPPGFTQHHQAC------FDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGF 2517
            T+G+   +  PG ++    C      +  ++C   P     HG+      +   EC  G+
Sbjct: 563  TIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGY------NQMMECLPGY 616

Query: 2518 TLVSSGHGCEDVNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSP 2576
              V++   C+D+NEC     C +G C N +G YRC+C  GF     ++ CV +      P
Sbjct: 617  KRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPD------P 669

Query: 2577 PTCGSAS---CRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRR-GPCSYSCANTPG-- 2630
            P          R    G +C+ P      + L  C       G+  GP    C   PG  
Sbjct: 670  PVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCS-----VGKAWGPHCEKCP-LPGTA 723

Query: 2631 GFLCGCPQGYFRAGQGHCVSGL 2652
             F   CP      G G+ VSG+
Sbjct: 724  AFKEICP-----GGMGYTVSGV 740



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 1/57 (1%)

Query: 1790 KCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCM 1846
            +C  GYK      C   NEC ++  VC +G+C++T GSY C C  GF      + C+
Sbjct: 611  ECLPGYKRVNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 25/75 (33%), Positives = 29/75 (38%), Gaps = 7/75 (9%)

Query: 122 VSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCE-- 179
           V+   G  C G S    K      C +P C   C NGG C+ P  C C  G  G  CE  
Sbjct: 166 VNVCGGRCCHGWS----KAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETI 221

Query: 180 -RDYRTGPCFGQVGP 193
                + P FG   P
Sbjct: 222 AAQDTSSPVFGGQSP 236



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 4/66 (6%)

Query: 2579 CGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC---AGRRGPC-SYSCANTPGGFLC 2634
            C +  C     G+ C C  G+  D A   C +V+EC     R   C +  C NT G + C
Sbjct: 1632 CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKC 1691

Query: 2635 GCPQGY 2640
             C  GY
Sbjct: 1692 LCLPGY 1697



 Score = 39.3 bits (90), Expect = 0.055
 Identities = 45/203 (22%), Positives = 68/203 (33%), Gaps = 51/203 (25%)

Query: 2399 TATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQ 2458
            T  T    ++C + PK  ++   N     +  C  GY    +   C+D++EC  +     
Sbjct: 584  TVGTSWGFNKCQKCPKKPSYHGYNQ----MMECLPGYK-RVNNTFCQDINECQLQGVCPN 638

Query: 2459 FLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFT 2518
              C+NT+G++ C C  GF                 GP      C   P     E    + 
Sbjct: 639  GECLNTMGSYRCTCKIGF-----------------GPDPTFSSCVPDPPVISEEKGPCYR 681

Query: 2519 LVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPT 2578
            LVSSG             +C H     L    C C  G        +C          P 
Sbjct: 682  LVSSG------------RQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC----------PL 719

Query: 2579 CGSASCRNTLGGFRCVCPSGFDF 2601
             G+A+       F+ +CP G  +
Sbjct: 720  PGTAA-------FKEICPGGMGY 735



 Score = 39.3 bits (90), Expect = 0.055
 Identities = 18/49 (36%), Positives = 22/49 (44%), Gaps = 1/49 (2%)

Query: 2110 ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEP 2158
            EC  GY        C D +EC +   C  G C N +G + C C  GF P
Sbjct: 611  ECLPGYKR-VNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGP 658



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 22/96 (22%)

Query: 1724 ECGE-IPAICANGICINQIGSF----RCE-CP---AGFNYNSILLA-----------CED 1763
            +CG+ +P +     C   +G+     +C+ CP   +   YN ++             C+D
Sbjct: 567  QCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQD 626

Query: 1764 VDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSP 1799
            ++EC   +  C  N +C+N  GSYRC C  G+   P
Sbjct: 627  INEC-QLQGVCP-NGECLNTMGSYRCTCKIGFGPDP 660



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 8/71 (11%)

Query: 2413 PKPCTFLCKNTKGSFLCSCPRGY---LLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469
            P  C   C  TKGS   SC +G    L+ E+G     L     R   C   C+N     +
Sbjct: 358  PSICKVTC--TKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSS 415

Query: 2470 ---CRCPPGFT 2477
               C+CPP FT
Sbjct: 416  RDKCQCPPNFT 426



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%)

Query: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD 1315
            C  GY  R   T C D++EC++ G     +  CLN  GS+ C C  G+  D
Sbjct: 612  CLPGYK-RVNNTFCQDINECQLQG--VCPNGECLNTMGSYRCTCKIGFGPD 659



 Score = 32.7 bits (73), Expect = 5.2
 Identities = 23/76 (30%), Positives = 27/76 (35%), Gaps = 9/76 (11%)

Query: 2507 GSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQC 2566
            G  R + HQ   L       + VN C G  RC HG     G  RC+ P           C
Sbjct: 151  GGSRLQVHQKQQL-------QGVNVCGG--RCCHGWSKAPGSQRCTKPSCVPPCQNGGMC 201

Query: 2567 VDENECALSPPTCGSA 2582
            +    C   P T G A
Sbjct: 202  LRPQLCVCKPGTKGKA 217


>gi|46249412 latent transforming growth factor beta binding protein 1
            isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  532 bits (1370), Expect = e-150
 Identities = 304/848 (35%), Positives = 426/848 (50%), Gaps = 102/848 (12%)

Query: 1027 TDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGT 1086
            T+I+EC ++PD+CG G C+N P  + C C+ GY       + C+D+DEC +   LC  G 
Sbjct: 547  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQ-QRKCVDIDECTQVQHLCSQGR 605

Query: 1087 CTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCS-CHAGFQ 1145
            C NT+GS+ C CP G   + +GT C D+DEC L   +C  G CVN +GAF+C  C +G++
Sbjct: 606  CENTEGSFLCICPAGFMASEEGTNCIDVDEC-LRPDVCGEGHCVNTVGAFRCEYCDSGYR 664

Query: 1146 STPDRQGCVDINECRVQNGGCDVHCINTEGSYRC-SCGQGYSLMPDGRACADVDECEENP 1204
             T  R  C DI+EC   +   D  C+N+ GSY+C  C +G+        C DVDEC E P
Sbjct: 665  MT-QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGW--NGQCLDVDECLE-P 720

Query: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCH 1264
             VC  G C+N+ G + C C+ G+  TPD + C D+DEC    ++C++G C+NT+GSF C 
Sbjct: 721  NVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQ-QGNLCVNGQCKNTEGSFRCT 779

Query: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGW--VGDGFECHDL 1322
            C  GY +      C D+DEC+   H C +H  C N  GSF C C  G+   G G  C D+
Sbjct: 780  CGQGYQLSAAKDQCEDIDECQ-HRHLC-AHGQCRNTEGSFQCVCDQGYRASGLGDHCEDI 837

Query: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGF-AGDGFFCEDRDECAENVDLC-DNGQCLN 1380
            +EC+  +  C  RGDC+N  GSY CTC  GF   D   C+D +EC E+  LC   G+CLN
Sbjct: 838  NECLEDKSVCQ-RGDCINTAGSYDCTCPDGFQLDDNKTCQDINEC-EHPGLCGPQGECLN 895

Query: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLC-AFGSCENLPGMFRCICNGGYELDRG 1439
              G + C C+ GF  + D R C+D+DEC    +C + G C+N  G FRC+C  G++  + 
Sbjct: 896  TEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQD 955

Query: 1440 GGNCTDINECADPVN-CINGVCINTPGSYLCSC-PQDFELNPSGVGC---------VDT- 1487
            G  C D+NEC      C    C N  GS+LC C  ++ E +P    C         VD  
Sbjct: 956  GQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVD 1015

Query: 1488 ----RAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCEL--CPMANTTE 1541
                    C+   +D       C   +   VT+  CCC+ G  WG+ CE+  CP+  T E
Sbjct: 1016 QPKEEKKECYYNLNDAS----LCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE 1071

Query: 1542 YRTLCPGGEGFQPNRITVI------LEDIDEC----QELPGLCQGGDCVNTFGSFQCECP 1591
            +  +CP G+GF P   +         +D DEC    QE   +C+ G C+NT   ++C C 
Sbjct: 1072 FTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE---ICKNGFCLNTRPGYECYCK 1128

Query: 1592 PGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCM----- 1646
             G +       C D+DEC   S  C  G C NT G+Y C C    +       C+     
Sbjct: 1129 QGTYYDPVKLQCFDMDECQDPSS-CIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAES 1187

Query: 1647 -------DMRKSVCFRHYNG--TCQNEL-AFNVTRKMCCCSYNIGQAWNRPCEACPTPIS 1696
                   D+ + +C+ H +    C   L     T   CCC Y  G+AW   C  CP   S
Sbjct: 1188 NEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY--GEAWGMQCALCPLKDS 1245

Query: 1697 PDYQILC-----------GNQA-------------PGFLTD--IHTGKPLDIDECGEIPA 1730
             DY  LC           G  A             P F+ D  +++ + L  +ECG +  
Sbjct: 1246 DDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG 1305

Query: 1731 ICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC---GSRESPCQQNADCINIPGSY 1787
             C NG C+     + C+C  G++ ++  + C DV+EC    +R S C +NA CIN  GSY
Sbjct: 1306 -CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNAKCINTDGSY 1363

Query: 1788 RCKCTRGY 1795
            +C C  GY
Sbjct: 1364 KCLCLPGY 1371



 Score =  472 bits (1215), Expect = e-132
 Identities = 360/1197 (30%), Positives = 502/1197 (41%), Gaps = 184/1197 (15%)

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGL-PCELCPAQPH--------PCRRG 235
            G CF +     C   L GL   +  CC TVG +WG   C+ CP +P          C  G
Sbjct: 231  GRCFQETIGSQCGKALPGL-SKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPG 289

Query: 236  FIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACE------D 289
            +   ++   CQD++ECQ + G+C  G C+N +GS+ C C +G     + ++C        
Sbjct: 290  Y-KRVNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVIS 347

Query: 290  YRAGACFSVLFGGR-CAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLC-- 346
               G C+ ++  GR C   L+ H T++ CCC  G+ W  GP  E CP  G+  F+++C  
Sbjct: 348  EEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAW--GPHCEKCPLPGTAAFKEICPG 405

Query: 347  --------AQRLPLLPGHPGLFPGLL------GFGSNGMGPPL----------------G 376
                      R   +  H G  P  +          +   PPL                G
Sbjct: 406  GMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHG 465

Query: 377  PARLNPHGSDA---RGIPSLG-------PGNSNIGTATLNQTIDICRHFTNLCLNGRCLP 426
            P    P  + A   + IPSL        PG   +       TI +   F  + +     P
Sbjct: 466  PGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGI--STIHLHPQFPGIVIEKTSPP 523

Query: 427  TPSSYRCECNVGYTQDVRG--ECIDVDECTSSP--CHHGDCVNIPGTYHCRCYPGFQATP 482
             P     E +      V    +  +++ECT +P  C  G C+N+P  Y C CY G++ + 
Sbjct: 524  VPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSE 583

Query: 483  TRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCV 542
             ++ CVD+DEC     LC  GRC NTEGSF C+C AGF  S +G NC+D +EC    +C 
Sbjct: 584  QQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCG 643

Query: 543  NGVCLNEDGSFSC-LCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRC-QCLG 600
             G C+N  G+F C  C  G+ +   G  C DIDEC  P  C +  C N+ GS++C  C  
Sbjct: 644  EGHCVNTVGAFRCEYCDSGYRMTQRGR-CEDIDECLNPSTCPDEQCVNSPGSYQCVPCTE 702

Query: 601  GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN------PDHGFG-- 652
            G   G +G+ C+D          +E   CA      +  S  C  +      PDH     
Sbjct: 703  GFR-GWNGQ-CLDVD------ECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRD 754

Query: 653  -EPCQ---LCP----AKDSAEFQALCSSGLGITT---DGRDINECALDPEVCANGVCENL 701
             + CQ   LC           F+  C  G  ++       DI+EC     +CA+G C N 
Sbjct: 755  IDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ-HRHLCAHGQCRNT 813

Query: 702  RGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDT 761
             GS++CVC+ GY A   G  C D++EC  +  +C  G C N+ GSY C+CP GF    D 
Sbjct: 814  EGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDN 872

Query: 762  EICKDVDEC----LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQ 817
            + C+D++EC    L  P   G C N  GS+ C C  G  +   G  C D         I 
Sbjct: 873  KTCQDINECEHPGLCGP--QGECLNTEGSFHCVCQQGFSISADGRTCED---------ID 921

Query: 818  ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF-ARMTGVTCDDVNECESF 876
            E    VN         C  T G+       RC     C +GF A   G  C DVNECE  
Sbjct: 922  EC---VNNTVCDSHGFCDNTAGSF------RC----LCYQGFQAPQDGQGCVDVNECELL 968

Query: 877  PGVCPNGRCVNTAGSFRCECPE----------GLMLDASGRLCVDV-----RLEPCFLRW 921
             GVC    C N  GSF C C +                S  L VDV       + C+   
Sbjct: 969  SGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNL 1028

Query: 922  -DEDECGVTLPGKYRMDVCCCSIGAVWGVECE--ACPDPESLEFASLCPRGLGFASRDFL 978
             D   C   L        CCC+ GA WG  CE   CP   + EF  +CP+G GF      
Sbjct: 1029 NDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGES 1088

Query: 979  S---GRPFYKDVNECKVF-PGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRI 1034
            S   G   YKD +EC +F   +C +G C NT   + C C  G   D  +  C D+DEC+ 
Sbjct: 1089 SSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ- 1147

Query: 1035 SPDLCGQGTCVNTPGSFEC-------------ECFPGYESGFMLMKNCMDVDEC---ARD 1078
             P  C  G CVNT GS+ C              C    ES   + +  +  D C     D
Sbjct: 1148 DPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSD 1207

Query: 1079 PLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC--EDIDE----CSL--SDGLCPHGQCV 1130
              +C            +C C  G     +   C  +D D+    C++  +    P+G+  
Sbjct: 1208 EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDA 1267

Query: 1131 NVIGAFQCSCHAGFQSTPDR----QGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYS 1186
             V  + Q +  A      DR       +   EC + NG  +  C+  +  Y C C  GY 
Sbjct: 1268 LVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYH 1327

Query: 1187 LMPDGRACADVDECEE-NPR--VCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVD 1240
            L      C DV+EC+E N R  +C    C N  G ++CLC  G++ +     C  ++
Sbjct: 1328 LDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384



 Score =  440 bits (1132), Expect = e-123
 Identities = 288/889 (32%), Positives = 396/889 (44%), Gaps = 154/889 (17%)

Query: 869  DVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGV 928
            ++NEC   P +C  G C+N    + C C EG       R CVD+           DEC  
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDI-----------DECTQ 596

Query: 929  TLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVN 988
                        CS G         C + E   F  +CP G   AS +  +      DV+
Sbjct: 597  VQH--------LCSQGR--------CENTEG-SFLCICPAGF-MASEEGTN----CIDVD 634

Query: 989  ECKVFPGLCTHGTCRNTVGSFHCA-CAGGFALDAQERNCTDIDECRISPDLCGQGTCVNT 1047
            EC + P +C  G C NTVG+F C  C  G+ +  Q   C DIDEC ++P  C    CVN+
Sbjct: 635  EC-LRPDVCGEGHCVNTVGAFRCEYCDSGYRM-TQRGRCEDIDEC-LNPSTCPDEQCVNS 691

Query: 1048 PGSFEC----ECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHE 1103
            PGS++C    E F G+         C+DVDEC  +P +C  G C+N +GSY C C  G+ 
Sbjct: 692  PGSYQCVPCTEGFRGWNG------QCLDVDECL-EPNVCANGDCSNLEGSYMCSCHKGYT 744

Query: 1104 LTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQN 1163
             T     C DIDEC   + LC +GQC N  G+F+C+C  G+Q +  +  C DI+EC+ ++
Sbjct: 745  RTPDHKHCRDIDECQQGN-LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRH 803

Query: 1164 GGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLC 1223
                  C NTEGS++C C QGY     G  C D++EC E+  VC +G C N  G + C C
Sbjct: 804  LCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTC 863

Query: 1224 YDGFMATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVCHCQLGYMVRKGATGCSDVD 1282
             DGF    D +TC D++EC+ +P +C   G+C NT+GSF C CQ G+ +      C D+D
Sbjct: 864  PDGFQLD-DNKTCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDID 921

Query: 1283 ECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG--DGFECHDLDECVSQEHRCSPRGDCLN 1340
            EC V    CDSH  C N  GSF C C  G+    DG  C D++EC      C     C N
Sbjct: 922  EC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG-EAFCEN 979

Query: 1341 VPGSYRCTC---RQGFAGDGFFC----------------EDRDECAENVD---LCDNGQ- 1377
            V GS+ C C    Q ++     C                E++ EC  N++   LCDN   
Sbjct: 980  VEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLA 1039

Query: 1378 --------CLNAPGGYRCECEM-------------------GFDPTEDHRA------CQD 1404
                    C  +  G+   CE+                   GF P  +  +       +D
Sbjct: 1040 PNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1099

Query: 1405 VDECAQ--GNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCIN 1462
             DEC      +C  G C N    + C C  G   D     C D++EC DP +CI+G C+N
Sbjct: 1100 ADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVN 1159

Query: 1463 TPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHD---------RGDSGISCSAEIGVG 1513
            T GSY C C     L+ S   C+     N  +E  D           D  +     +G  
Sbjct: 1160 TEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQ 1219

Query: 1514 VTRASCCCSLGRAWGNPCELCPMANTTEYRTLC---------PGG--------EGFQPNR 1556
             T   CCC  G AWG  C LCP+ ++ +Y  LC         P G        E + P  
Sbjct: 1220 TTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEA 1279

Query: 1557 ITVILED----------IDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI 1606
                ++D           +EC  L G C+ G CV     + C+C  GYHL      C D+
Sbjct: 1280 DPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDV 1338

Query: 1607 DEC---STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSV 1652
            +EC   +    +C    C NT G+Y C+C   Y+  +  N C  +  ++
Sbjct: 1339 NECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1387



 Score =  432 bits (1110), Expect = e-120
 Identities = 277/868 (31%), Positives = 405/868 (46%), Gaps = 121/868 (13%)

Query: 1807 NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP--CGNGTCKNI 1864
            NEC   P++C  G C++    Y C+C+ G++ S  Q  C+DIDEC +    C  G C+N 
Sbjct: 550  NECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENT 609

Query: 1865 IGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHC-LCQDGFELTA 1922
             GS+ C+C  GF+ +  G +C+D DEC  L   VC  GHC+NT G+F C  C  G+ +T 
Sbjct: 610  EGSFLCICPAGFMASEEGTNCIDVDEC--LRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 667

Query: 1923 DGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI-CPPGFQVQSDHCIDIDECSEEPNLCL 1981
             G+ C D +ECL+   TC    C N  GS++C+ C  GF+  +  C+D+DEC E PN+C 
Sbjct: 668  RGR-CEDIDECLN-PSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLE-PNVCA 724

Query: 1982 FGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKT-RCC 2040
             G C+N  GS+ C C  G+  + +   C D  +         G+C      NT  + RC 
Sbjct: 725  NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCK-----NTEGSFRCT 779

Query: 2041 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC 2100
            C    G+G+         + SAA                D  ED++EC ++  +C +G C
Sbjct: 780  C----GQGY---------QLSAA---------------KDQCEDIDEC-QHRHLCAHGQC 810

Query: 2101 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP-CGQGTCTNVIGGFECACADGFEPG 2159
             NT+GSF+C C  GY     G +C D +EC      C +G C N  G ++C C DGF+  
Sbjct: 811  RNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 870

Query: 2160 LMMTCEDIDECSLNPLLCAFR--CHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
               TC+DI+EC  +P LC  +  C NTEGS+ C C  G+++  DG  C D+DEC +    
Sbjct: 871  DNKTCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTV- 928

Query: 2218 CHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRC 2277
            C + G  C N  G+F C+C  G +  P  G+GC D NEC     +C    C N  GSF C
Sbjct: 929  CDSHGF-CDNTAGSFRCLCYQGFQA-PQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC 986

Query: 2278 DC-DEGFQPSPTLTECHDIRQGPCFAEVLQ---------------TMCRSLSSSSEAVTR 2321
             C DE  + SP   +C          +V Q               ++C ++ + +  VT+
Sbjct: 987  VCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN--VTK 1044

Query: 2322 AECCCGGGRGWGPRCEL--CPLPGTSAYRKLCPHGSGYTAEG-----------RDVDECR 2368
             ECCC  G GWG  CE+  CP+ GT+ + ++CP G G+   G           +D DEC 
Sbjct: 1045 QECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECL 1104

Query: 2369 MLAH-LCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSF 2427
            +    +C +G C+N+   + C+C+ G   D     C DMDEC          C NT+GS+
Sbjct: 1105 LFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSY 1164

Query: 2428 LCSCPRGYLLEEDGRTC-------KDLDECTSRQHNC------QFLCVN-TVGAFT---- 2469
             C C    +L+   + C       + ++E    Q  C      +++C    VG  T    
Sbjct: 1165 NCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTE 1224

Query: 2470 CRCPPGFTQHHQACF----DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHG 2525
            C C  G     Q       D+D+  AQ       G           +  + +T  +  + 
Sbjct: 1225 CCCLYGEAWGMQCALCPLKDSDD-YAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYF 1283

Query: 2526 CED----------VNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENEC-- 2572
             +D            EC   + C++G C     GY C C  G+   +    CVD NEC  
Sbjct: 1284 IQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDE 1343

Query: 2573 -ALSPPTCGSASCRNTLGGFRCVCPSGF 2599
                   C +A C NT G ++C+C  G+
Sbjct: 1344 LNNRMSLCKNAKCINTDGSYKCLCLPGY 1371



 Score =  408 bits (1048), Expect = e-113
 Identities = 276/844 (32%), Positives = 382/844 (45%), Gaps = 104/844 (12%)

Query: 1530 PCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCE 1589
            P E+ P A+T+         +   P ++T    +I+EC   P +C  G C+N    + C 
Sbjct: 525  PVEVAPEASTSS------ASQVIAPTQVT----EINECTVNPDICGAGHCINLPVRYTCI 574

Query: 1590 CPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMD-- 1647
            C  GY  SE  R C DIDEC+    +C  G C NT G++ C+CPA ++    G NC+D  
Sbjct: 575  CYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVD 634

Query: 1648 --MRKSVCFRHYNGTCQNEL-AFNVTRKMCCCSYNIGQAWN-RPCEACPTPIS-PDYQIL 1702
              +R  VC     G C N + AF    + C   Y + Q       + C  P + PD Q  
Sbjct: 635  ECLRPDVCGE---GHCVNTVGAFRC--EYCDSGYRMTQRGRCEDIDECLNPSTCPDEQ-- 687

Query: 1703 CGNQAPGFLTDIH--------TGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNY 1754
            C N +PG    +          G+ LD+DEC E P +CANG C N  GS+ C C  G+  
Sbjct: 688  CVN-SPGSYQCVPCTEGFRGWNGQCLDVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTR 745

Query: 1755 NSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG-GACVGRNECREIP 1813
                  C D+DEC  ++     N  C N  GS+RC C +GY+LS     C   +EC+   
Sbjct: 746  TPDHKHCRDIDEC--QQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH-R 802

Query: 1814 NVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCL 1871
            ++C+HG C +TEGS+ C+C +G++AS     C DI+EC  D+  C  G C N  GSY+C 
Sbjct: 803  HLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCT 862

Query: 1872 CFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
            C  GF +  N  C D +EC    G     G CLNT GSFHC+CQ GF ++ADG+ C D +
Sbjct: 863  CPDGFQLDDNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDID 921

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989
            EC++       G C N  GSFRC+C  GFQ   D   C+D++EC     +C    C N  
Sbjct: 922  ECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVE 981

Query: 1990 GSFQCLCP----------------PGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFN 2033
            GSF C+C                     L  +  +  + ++   +   +A  C    A N
Sbjct: 982  GSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN 1041

Query: 2034 TTKTRCCCSKRPGEGWGDPCEL--CPQEGSAAFQELCPFGHGAVPGPDDSRE-------D 2084
             TK  CCC+   G GWGD CE+  CP  G+A F E+CP G G VP  + S E       D
Sbjct: 1042 VTKQECCCTS--GAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1099

Query: 2085 VNEC-AENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTN 2143
             +EC      +C NG C+NT   + C C  G   D   + C D DEC     C  G C N
Sbjct: 1100 ADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVN 1159

Query: 2144 VIGGFECACA-----DGFEPGLMMTC---EDIDECSLNPLLC------AFRCH----NTE 2185
              G + C C      D  E   +      E I+E  +   LC       + C       +
Sbjct: 1160 TEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQ 1219

Query: 2186 GSYL-CTCPAGYTLREDGAMC--RDVDECADGQQDCH-----ARGMECKNLIGTFACVCP 2237
             +Y  C C  G       A+C  +D D+ A   Q C+      R    ++ +  F+    
Sbjct: 1220 TTYTECCCLYGEAWGMQCALCPLKDSDDYA---QLCNIPVTGRRQPYGRDALVDFSEQYT 1276

Query: 2238 PGMRPLPGSGEGCTDDNECHAQP----DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECH 2293
            P   P            E  A+     + C NGRCV     + CDC +G+        C 
Sbjct: 1277 PEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCV 1336

Query: 2294 DIRQ 2297
            D+ +
Sbjct: 1337 DVNE 1340



 Score =  394 bits (1012), Expect = e-109
 Identities = 337/1199 (28%), Positives = 461/1199 (38%), Gaps = 298/1199 (24%)

Query: 90   CGE---GFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLC-QKGYTGTV 145
            CG+   G   Q + C    GT+  S G ++   C       G  +   CL   K    T 
Sbjct: 242  CGKALPGLSKQEDCC----GTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTF 297

Query: 146  CG-------QPICDRG-CHNGGRCIGPNRCACVYGFMGPQ-----CERD-----YRTGPC 187
            C        Q +C  G C N    +G  RC C  GF GP      C  D        GPC
Sbjct: 298  CQDINECQLQGVCPNGECLN---TMGSYRCTCKIGF-GPDPTFSSCVPDPPVISEEKGPC 353

Query: 188  FGQVGP-EGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQ 246
            +  V     C H L+ +  TK LCC +VG+AWG  CE CP          +P   T A +
Sbjct: 354  YRLVSSGRQCMHPLS-VHLTKQLCCCSVGKAWGPHCEKCP----------LPG--TAAFK 400

Query: 247  DVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR----AGACFSVLFGG 302
            ++         C GG    + G  H R P+ H +       +       A +        
Sbjct: 401  EI---------CPGGMGYTVSG-VHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPA 450

Query: 303  RCAGDLAGHYTRRQCCCDRGRCWAAGP---VPELCPPRGSNEFQQLCAQRLPLLPGHPGL 359
            +     A  ++R             GP    PE+       E   L  ++  L PG P L
Sbjct: 451  KEEPVEALTFSREH-----------GPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQL 499

Query: 360  FPGLL---------GFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTID 410
             PG+          G       PP+ P  + P  S +     + P        T    I+
Sbjct: 500  SPGISTIHLHPQFPGIVIEKTSPPV-PVEVAPEASTSSASQVIAP--------TQVTEIN 550

Query: 411  ICRHFTNLCLNGRCLPTPSSYRCECNVGYT-QDVRGECIDVDECTSSP--CHHGDCVNIP 467
             C    ++C  G C+  P  Y C C  GY   + + +C+D+DECT     C  G C N  
Sbjct: 551  ECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTE 610

Query: 468  GTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQC-VCNAGFELSPDG 526
            G++ C C  GF A+     C+DVDEC+    +C  G CVNT G+F+C  C++G+ ++  G
Sbjct: 611  GSFLCICPAGFMASEEGTNCIDVDECL-RPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRG 669

Query: 527  K---------------------------------------NCVDHNECATSTMCVNGVCL 547
            +                                        C+D +EC    +C NG C 
Sbjct: 670  RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCS 729

Query: 548  NEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTD 607
            N +GS+ C C  G+   P   +C DIDECQ   +CVNG C NTEGSFRC C  G  +   
Sbjct: 730  NLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAA 789

Query: 608  GRVCVD---THVRSTCYGAIEKGSCARPFPGTVTKSECCC--ANPDHGFGEPCQLCPAKD 662
               C D      R  C      G C      T    +C C       G G+ C+     +
Sbjct: 790  KDQCEDIDECQHRHLC----AHGQCR----NTEGSFQCVCDQGYRASGLGDHCE--DINE 839

Query: 663  SAEFQALCSSGLGITTDG------------------RDINECALDPEVCA-NGVCENLRG 703
              E +++C  G  I T G                  +DINEC   P +C   G C N  G
Sbjct: 840  CLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE-HPGLCGPQGECLNTEG 898

Query: 704  SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763
            S+ CVC  G+   A G+ C D+DEC  N++   +G+C N+ GS+ C C  GF   QD + 
Sbjct: 899  SFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQG 958

Query: 764  CKDVDEC--LSSPCVSGVCRNLAGSYTCKCG-PGSRLDPSGTFCLDSTKGTCWL-----K 815
            C DV+EC  LS  C    C N+ GS+ C C        P    C   T     +     K
Sbjct: 959  CVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPK 1018

Query: 816  IQESRCEVNLQGASL----------RSECCATLGAAWGSPCERCEIDPACARGFARMT-- 863
             ++  C  NL  ASL          + ECC T GA WG   + CEI P    G A  T  
Sbjct: 1019 EEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWG---DNCEIFPCPVLGTAEFTEM 1075

Query: 864  ------------------GVTCDDVNECESF----------------------------- 876
                              G    D +EC  F                             
Sbjct: 1076 CPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDP 1135

Query: 877  -------------PGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCV------------D 911
                         P  C +G+CVNT GS+ C C   ++LDAS + C+            D
Sbjct: 1136 VKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETD 1195

Query: 912  VRLEPCFLRW-DEDECGVTLPGKY-RMDVCCCSIGAVWGVECEACPDPESLEFASLC--- 966
            V  + C+    DE  C   L GK      CCC  G  WG++C  CP  +S ++A LC   
Sbjct: 1196 VYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIP 1255

Query: 967  ------PRG----LGFASRDFLSGRPFY-----------KDVNECKVFPGLCTHGTCRNT 1005
                  P G    + F+ +      P++               EC +  G C +G C   
Sbjct: 1256 VTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRV 1314

Query: 1006 VGSFHCACAGGFALDAQERNCTDIDEC-----RISPDLCGQGTCVNTPGSFECECFPGY 1059
               + C C  G+ LD  +  C D++EC     R+S  LC    C+NT GS++C C PGY
Sbjct: 1315 QEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMS--LCKNAKCINTDGSYKCLCLPGY 1371



 Score =  394 bits (1012), Expect = e-109
 Identities = 364/1244 (29%), Positives = 491/1244 (39%), Gaps = 248/1244 (19%)

Query: 1308 CLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDE 1365
            CLPG+  V + F C D++EC  Q     P G+CLN  GSYRCTC+ GF  D  F      
Sbjct: 286  CLPGYKRVNNTF-CQDINEC--QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTF----SS 338

Query: 1366 CAENVDLC--DNGQCLN-APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG-SCEN 1421
            C  +  +   + G C      G +C       P   H   Q +  C+ G   A+G  CE 
Sbjct: 339  CVPDPPVISEEKGPCYRLVSSGRQC-----MHPLSVHLTKQ-LCCCSVGK--AWGPHCEK 390

Query: 1422 LP----GMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477
             P      F+ IC GG                      ++GV    P  +       F +
Sbjct: 391  CPLPGTAAFKEICPGGMGY------------------TVSGVHRRRPIHHHVGKGPVF-V 431

Query: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
             P     V        L   +     ++ S E G GV       +       P E    +
Sbjct: 432  KPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATA-------PPEKEIPS 484

Query: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLS 1597
               E   L PG     P   T+ L       + PG+        T      E  P    S
Sbjct: 485  LDQEKTKLEPGQPQLSPGISTIHLH-----PQFPGIV----IEKTSPPVPVEVAPEASTS 535

Query: 1598 EHTRICEDIDECSTHSGICGPGTC-----YNTLGNYTCVCPAEYLQVNGGNNCMDMRKSV 1652
              +++         +     P  C      N    YTC+C   Y        C+D+ +  
Sbjct: 536  SASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECT 595

Query: 1653 CFRHY--NGTCQN-ELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPG 1709
              +H    G C+N E +F     +C C                                G
Sbjct: 596  QVQHLCSQGRCENTEGSF-----LCIC------------------------------PAG 620

Query: 1710 FLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCE-CPAGFNYNSILLACEDVDECG 1768
            F+        +D+DEC   P +C  G C+N +G+FRCE C +G+        CED+DEC 
Sbjct: 621  FMASEEGTNCIDVDECLR-PDVCGEGHCVNTVGAFRCEYCDSGYRMTQ-RGRCEDIDEC- 677

Query: 1769 SRESPCQQNADCINIPGSYRC-KCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGS 1827
               S C  +  C+N PGSY+C  CT G++    G C+  +EC E PNVC++GDC + EGS
Sbjct: 678  LNPSTC-PDEQCVNSPGSYQCVPCTEGFR-GWNGQCLDVDECLE-PNVCANGDCSNLEGS 734

Query: 1828 YMCLCHRGFQASADQTLCMDIDECDR-QPCGNGTCKNIIGSYNCLCFPGFVVTHNGD-CV 1885
            YMC CH+G+  + D   C DIDEC +   C NG CKN  GS+ C C  G+ ++   D C 
Sbjct: 735  YMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE 794

Query: 1886 DFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTC 1945
            D DEC      +C  G C NT GSF C+C  G+  +  G +C D NECL     C  G C
Sbjct: 795  DIDECQH--RHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC 852

Query: 1946 QNLEGSFRCICPPGFQVQSDH-CIDIDECSEEPNLC-LFGTCTNSPGSFQCLCPPGFVLS 2003
             N  GS+ C CP GFQ+  +  C DI+EC E P LC   G C N+ GSF C+C  GF +S
Sbjct: 853  INTAGSYDCTCPDGFQLDDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSIS 911

Query: 2004 DNGHRCFDTRQSFCFTRFEA-GKCSVPKAFNTTKT-RCCCSKRPGEGWGDPCELCPQEGS 2061
             +G  C D  +    T  ++ G C      NT  + RC C                 +G 
Sbjct: 912  ADGRTCEDIDECVNNTVCDSHGFCD-----NTAGSFRCLC----------------YQGF 950

Query: 2062 AAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECP--------- 2112
             A Q+    G G V        DVNEC    GVC    C N +GSF C C          
Sbjct: 951  QAPQD----GQGCV--------DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPM 998

Query: 2113 FGYSLDFTGINC-VDTD-------ECSVGHPCGQGTCTNVIG----GFECACADGFEPGL 2160
             G     T  +  VD D       EC   +      C NV+       EC C  G   G 
Sbjct: 999  TGQCRSRTSTDLDVDVDQPKEEKKECYY-NLNDASLCDNVLAPNVTKQECCCTSGAGWG- 1056

Query: 2161 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCT-----CPAGYTLRE-DGAMCRDVDEC-AD 2213
                   D C + P         TE   +C       PAG +  E  G   +D DEC   
Sbjct: 1057 -------DNCEIFPCPVLGTAEFTE---MCPKGKGFVPAGESSSEAGGENYKDADECLLF 1106

Query: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAG 2273
            GQ+ C  +   C N    + C C  G    P   + C D +EC   P  C++G+CVNT G
Sbjct: 1107 GQEIC--KNGFCLNTRPGYECYCKQGTYYDPVKLQ-CFDMDECQ-DPSSCIDGQCVNTEG 1162

Query: 2274 SFRCDCDEGFQPSPTLTEC------------HDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
            S+ C C        +   C             D+ Q  C+  +      S     +  T 
Sbjct: 1163 SYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTY 1222

Query: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLC---------PHG--------SGYTAEG--- 2361
             ECCC  G  WG +C LCPL  +  Y +LC         P+G          YT E    
Sbjct: 1223 TECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPY 1282

Query: 2362 ------------RDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
                           +EC +L + C +G C+     + C C  GY  D    TC+D++EC
Sbjct: 1283 FIQDRFLNSFEELQAEECGIL-NGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC 1341

Query: 2410 SQVPKPCTFLCKNTK-----GSFLCSCPRGYLLEEDGRTCKDLD 2448
             ++    + LCKN K     GS+ C C  GY+  +    C  L+
Sbjct: 1342 DELNNRMS-LCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384



 Score =  367 bits (942), Expect = e-101
 Identities = 337/1194 (28%), Positives = 476/1194 (39%), Gaps = 222/1194 (18%)

Query: 529  CVDHNECATSTMCVNGVCLNEDGSFSCLCK------------------------PGFLLA 564
            C D NEC    +C NG CLN  GS+ C CK                        P + L 
Sbjct: 298  CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLV 357

Query: 565  PGGHYCMDIDE--------CQTPGICVNGHCTNTE----GSFRCQCLGGLAVGTDG---R 609
              G  CM            C + G     HC         +F+  C GG+     G   R
Sbjct: 358  SSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRR 417

Query: 610  VCVDTHV-------RSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFG--EPCQLCPA 660
              +  HV       +      + K +   P P      E    + +HG G  EP ++  A
Sbjct: 418  RPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEP-EVATA 476

Query: 661  KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRG------SYRCVCNLGYE 714
                E  +L      +     +  +  L P +    +     G      S      +  E
Sbjct: 477  PPEKEIPSLDQEKTKL-----EPGQPQLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPE 531

Query: 715  AGASGKD-------CTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV 767
            A  S           T+++EC +N  +C  G C N P  Y+C C  G+ F +    C D+
Sbjct: 532  ASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDI 591

Query: 768  DEC--LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQES-RCEVN 824
            DEC  +   C  G C N  GS+ C C  G          + S +GT  + + E  R +V 
Sbjct: 592  DECTQVQHLCSQGRCENTEGSFLCICPAGF---------MASEEGTNCIDVDECLRPDVC 642

Query: 825  LQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGR 884
             +G      C  T+GA       RCE    C  G+       C+D++EC + P  CP+ +
Sbjct: 643  GEG-----HCVNTVGAF------RCEY---CDSGYRMTQRGRCEDIDECLN-PSTCPDEQ 687

Query: 885  CVNTAGSFRC-ECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943
            CVN+ GS++C  C EG         C+DV           DEC         ++   C+ 
Sbjct: 688  CVNSPGSYQCVPCTEGFR--GWNGQCLDV-----------DEC---------LEPNVCAN 725

Query: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCR 1003
            G           D  +LE + +C    G+            +D++EC+    LC +G C+
Sbjct: 726  G-----------DCSNLEGSYMCSCHKGYTRTP---DHKHCRDIDECQQ-GNLCVNGQCK 770

Query: 1004 NTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGF 1063
            NT GSF C C  G+ L A +  C DIDEC+    LC  G C NT GSF+C C  GY +  
Sbjct: 771  NTEGSFRCTCGQGYQLSAAKDQCEDIDECQ-HRHLCAHGQCRNTEGSFQCVCDQGYRASG 829

Query: 1064 MLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL 1123
             L  +C D++EC  D  +C+ G C NT GSY C CP G +L    T C+DI+EC    GL
Sbjct: 830  -LGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKT-CQDINECE-HPGL 886

Query: 1124 C-PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVH--CINTEGSYRCS 1180
            C P G+C+N  G+F C C  GF  + D + C DI+EC V N  CD H  C NT GS+RC 
Sbjct: 887  CGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCL 945

Query: 1181 CGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMA-TPDMRTC--- 1236
            C QG+    DG+ C DV+ECE    VC +  C N+ G   C+C D     +P    C   
Sbjct: 946  CYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSR 1005

Query: 1237 ------VDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHN 1290
                  VDVD+       C +    N   + +C   L   V K    C+        G N
Sbjct: 1006 TSTDLDVDVDQPKEEKKECYY----NLNDASLCDNVLAPNVTKQECCCT---SGAGWGDN 1058

Query: 1291 CDSHASCLNIPGSFSCRCLPG----------WVGDGFECHDLDECVSQEHRCSPRGDCLN 1340
            C+     +     F+  C  G              G    D DEC+         G CLN
Sbjct: 1059 CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLN 1118

Query: 1341 VPGSYRCTCRQGFAGD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC--EMGFDPT 1396
                Y C C+QG   D     C D DEC ++   C +GQC+N  G Y C C   M  D +
Sbjct: 1119 TRPGYECYCKQGTYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDAS 1177

Query: 1397 EDH--RACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVN 1454
            E    R  +  ++  + ++      E+L   +  +C+         G  T   EC     
Sbjct: 1178 EKRCIRPAESNEQIEETDVYQDLCWEHLSDEY--VCSRPLV-----GKQTTYTECC---- 1226

Query: 1455 CING-----VCINTP------GSYLCSCPQDFELNPSGVGCV-------DTRAGNCFLET 1496
            C+ G      C   P       + LC+ P      P G   +          A   F++ 
Sbjct: 1227 CLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQ- 1285

Query: 1497 HDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNR 1556
                D  ++   E+     +A  C  L     N CE        E  T C   +G+  + 
Sbjct: 1286 ----DRFLNSFEEL-----QAEECGIL-----NGCENGRCVRVQEGYT-CDCFDGYHLDT 1330

Query: 1557 ITVILEDIDECQEL---PGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607
              +   D++EC EL     LC+   C+NT GS++C C PGY  S+    C  ++
Sbjct: 1331 AKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384



 Score =  365 bits (937), Expect = e-100
 Identities = 279/946 (29%), Positives = 385/946 (40%), Gaps = 195/946 (20%)

Query: 1364 DECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQ-GNLCAFGSCENL 1422
            +EC  N D+C  G C+N P  Y C C  G+  +E  R C D+DEC Q  +LC+ G CEN 
Sbjct: 550  NECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENT 609

Query: 1423 PGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCS-CPQDFELNPSG 1481
             G F CIC  G+     G NC D++EC  P  C  G C+NT G++ C  C   + +    
Sbjct: 610  EGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM---- 665

Query: 1482 VGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCC--CSLG-RAWGNPCELCPMAN 1538
                 T+ G C  E  D   +  +C  E  V    +  C  C+ G R W   C       
Sbjct: 666  -----TQRGRC--EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCL------ 712

Query: 1539 TTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSE 1598
                                    D+DEC E P +C  GDC N  GS+ C C  GY  + 
Sbjct: 713  ------------------------DVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTP 747

Query: 1599 HTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYN 1658
              + C DIDEC     +C  G C NT G++ C C   Y      + C D+ +        
Sbjct: 748  DHKHCRDIDECQ-QGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDE-------- 798

Query: 1659 GTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILC--GNQAPGFLTDIHT 1716
              CQ+       R +C      GQ  N             +Q +C  G +A G       
Sbjct: 799  --CQH-------RHLCAH----GQCRNT---------EGSFQCVCDQGYRASGLGDHCE- 835

Query: 1717 GKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESP--C 1774
                DI+EC E  ++C  G CIN  GS+ C CP GF  +     C+D++EC   E P  C
Sbjct: 836  ----DINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK-TCQDINEC---EHPGLC 887

Query: 1775 QQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCLCH 1833
                +C+N  GS+ C C +G+ +S  G  C   +EC       SHG C +T GS+ CLC+
Sbjct: 888  GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 947

Query: 1834 RGFQASADQTLCMDIDECDRQP--CGNGTCKNIIGSYNCLCFPGF--VVTHNGDC----- 1884
            +GFQA  D   C+D++EC+     CG   C+N+ GS+ C+C           G C     
Sbjct: 948  QGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTS 1007

Query: 1885 ----VDFDE-----------------CTTLVGQVCRFGHCLNTAGS--------FHCLCQ 1915
                VD D+                 C  ++        C  T+G+        F C   
Sbjct: 1008 TDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVL 1067

Query: 1916 DGFELT------------------ADGKNCVDTNECLSLAGT-CLPGTCQNLEGSFRCIC 1956
               E T                  A G+N  D +ECL      C  G C N    + C C
Sbjct: 1068 GTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYC 1127

Query: 1957 PPG--FQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCF---- 2010
              G  +      C D+DEC ++P+ C+ G C N+ GS+ C C    VL  +  RC     
Sbjct: 1128 KQGTYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE 1186

Query: 2011 --------DTRQSFCFTRF-EAGKCSVPKAFN-TTKTRCCCSKRPGEGWGDPCELCPQEG 2060
                    D  Q  C+    +   CS P     TT T CCC    GE WG  C LCP + 
Sbjct: 1187 SNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY--GEAWGMQCALCPLKD 1244

Query: 2061 SAAFQELC--PFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD 2118
            S  + +LC  P      P   D+  D +E                   +  E    +  D
Sbjct: 1245 SDDYAQLCNIPVTGRRQPYGRDALVDFSE------------------QYTPEADPYFIQD 1286

Query: 2119 --FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFE-PGLMMTCEDIDECS-LNP 2174
                    +  +EC + + C  G C  V  G+ C C DG+      MTC D++EC  LN 
Sbjct: 1287 RFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNN 1346

Query: 2175 L--LCA-FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
               LC   +C NT+GSY C C  GY   +    C  ++   + ++D
Sbjct: 1347 RMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKD 1392



 Score =  296 bits (758), Expect = 2e-79
 Identities = 202/621 (32%), Positives = 269/621 (43%), Gaps = 110/621 (17%)

Query: 2084 DVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTN 2143
            D++EC +   +C+ G C NT+GSF C CP G+     G NC+D DEC     CG+G C N
Sbjct: 590  DIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVN 649

Query: 2144 VIGGFECA-CADGFEPGLMMTCEDIDECSLNPLLCA-FRCHNTEGSYLCT-CPAGYTLRE 2200
             +G F C  C  G+       CEDIDEC LNP  C   +C N+ GSY C  C  G+  R 
Sbjct: 650  TVGAFRCEYCDSGYRMTQRGRCEDIDEC-LNPSTCPDEQCVNSPGSYQCVPCTEGF--RG 706

Query: 2201 DGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQP 2260
                C DVDEC   + +  A G +C NL G++ C C  G    P   + C D +EC  Q 
Sbjct: 707  WNGQCLDVDECL--EPNVCANG-DCSNLEGSYMCSCHKGYTRTP-DHKHCRDIDECQ-QG 761

Query: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT 2320
            +LCVNG+C NT GSFRC C +G+Q S    +C DI +           CR+   S     
Sbjct: 762  NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGS----- 816

Query: 2321 RAECCCGGG---RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG 2377
              +C C  G    G G  CE                         D++EC     +C  G
Sbjct: 817  -FQCVCDQGYRASGLGDHCE-------------------------DINECLEDKSVCQRG 850

Query: 2378 ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPC--TFLCKNTKGSFLCSCPRGY 2435
            +CIN+ GS+ C C  G+  D    TC D++EC   P  C     C NT+GSF C C +G+
Sbjct: 851  DCINTAGSYDCTCPDGFQLDDN-KTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGF 908

Query: 2436 LLEEDGRTCKDLDECTSRQ-HNCQFLCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQ 2492
             +  DGRTC+D+DEC +    +    C NT G+F C C  GF   Q  Q C D +EC   
Sbjct: 909  SISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELL 968

Query: 2493 PGPCGAHGHCHNTPGSFRCEC---HQGFTLVSSG------------------------HG 2525
             G CG    C N  GSF C C   +Q ++ ++                          + 
Sbjct: 969  SGVCG-EAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYN 1027

Query: 2526 CEDVNECD---GPHRCQHGCQNQLG---GYRCS---------------CPQG-------- 2556
              D + CD    P+  +  C    G   G  C                CP+G        
Sbjct: 1028 LNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGE 1087

Query: 2557 FTQHSQWAQCVDENECAL-SPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECA 2615
             +  +      D +EC L     C +  C NT  G+ C C  G  +D     C ++DEC 
Sbjct: 1088 SSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ 1147

Query: 2616 GRRGPCSYSCANTPGGFLCGC 2636
                     C NT G + C C
Sbjct: 1148 DPSSCIDGQCVNTEGSYNCFC 1168



 Score =  228 bits (580), Expect = 8e-59
 Identities = 141/407 (34%), Positives = 189/407 (46%), Gaps = 50/407 (12%)

Query: 2251 TDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCR 2310
            T+ NEC   PD+C  G C+N    + C C EG++ S    +C DI               
Sbjct: 547  TEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDI--------------- 591

Query: 2311 SLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGR---DVDEC 2367
                  +  T+ +  C  GR     CE        ++  +CP G   + EG    DVDEC
Sbjct: 592  ------DECTQVQHLCSQGR-----CENTE----GSFLCICPAGFMASEEGTNCIDVDEC 636

Query: 2368 RMLAHLCAHGECINSLGSFRC-HCQAGYTPDATATTCLDMDECSQVPKPCTF-LCKNTKG 2425
             +   +C  G C+N++G+FRC +C +GY        C D+DEC   P  C    C N+ G
Sbjct: 637  -LRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGR-CEDIDECLN-PSTCPDEQCVNSPG 693

Query: 2426 SFLC-SCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ--HHQA 2482
            S+ C  C  G+        C D+DEC          C N  G++ C C  G+T+   H+ 
Sbjct: 694  SYQCVPCTEGF--RGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKH 751

Query: 2483 CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG- 2541
            C D DEC  Q G    +G C NT GSFRC C QG+ L ++   CED++EC   H C HG 
Sbjct: 752  CRDIDEC--QQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQ 809

Query: 2542 CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDF 2601
            C+N  G ++C C QG+        C D NEC      C    C NT G + C CP GF  
Sbjct: 810  CRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL 869

Query: 2602 DQALGGCQEVDECA--GRRGPCSYSCANTPGGFLCGCPQGYFRAGQG 2646
            D     CQ+++EC   G  GP    C NT G F C C QG+  +  G
Sbjct: 870  DDNKT-CQDINECEHPGLCGPQG-ECLNTEGSFHCVCQQGFSISADG 914



 Score =  211 bits (538), Expect = 6e-54
 Identities = 115/292 (39%), Positives = 152/292 (52%), Gaps = 11/292 (3%)

Query: 2363 DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF-LCK 2421
            +++EC +   +C  G CIN    + C C  GY        C+D+DEC+QV   C+   C+
Sbjct: 548  EINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCE 607

Query: 2422 NTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCR-CPPGFTQHH 2480
            NT+GSFLC CP G++  E+G  C D+DEC       +  CVNTVGAF C  C  G+    
Sbjct: 608  NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 667

Query: 2481 QA-CFDNDECSAQPGPCGAHGHCHNTPGSFRC-ECHQGFTLVSSGHGCEDVNECDGPHRC 2538
            +  C D DEC   P  C     C N+PGS++C  C +GF        C DV+EC  P+ C
Sbjct: 668  RGRCEDIDEC-LNPSTCPDE-QCVNSPGSYQCVPCTEGFR--GWNGQCLDVDECLEPNVC 723

Query: 2539 QHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPS 2597
             +G C N  G Y CSC +G+T+      C D +EC      C +  C+NT G FRC C  
Sbjct: 724  ANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN-LCVNGQCKNTEGSFRCTCGQ 782

Query: 2598 GFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQG-HC 2648
            G+    A   C+++DEC  R       C NT G F C C QGY  +G G HC
Sbjct: 783  GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHC 834



 Score =  116 bits (290), Expect = 4e-25
 Identities = 149/644 (23%), Positives = 209/644 (32%), Gaps = 155/644 (24%)

Query: 55   QGPNVCGSRFHAYCCPGWRTFPGRSQCV-VPIC--RRACGEGFCSQPN---LCTCADGTL 108
            Q  N  GS F   C  G++    + QC  +  C  R  C  G C        C C  G  
Sbjct: 768  QCKNTEGS-FRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGY- 825

Query: 109  APSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPIC----------DRGCHNG 158
                   R SG    C +   C     +CQ+G      G   C          ++ C + 
Sbjct: 826  -------RASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDI 878

Query: 159  GRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCA--TVGR 216
              C  P  C       GPQ E    T   F  V  +G      G  C     C   TV  
Sbjct: 879  NECEHPGLC-------GPQGEC-LNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCD 930

Query: 217  AWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRC-P 275
            + G       +    C +GF        C DV+EC+ + G+C    C N+ GSF C C  
Sbjct: 931  SHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 990

Query: 276  VGHRLSDSSAAC---------------EDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCD 320
                 S  +  C               ++ +    +++     C   LA + T+++CCC 
Sbjct: 991  ENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCT 1050

Query: 321  RGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARL 380
             G  W        CP  G+ EF ++C                                  
Sbjct: 1051 SGAGWGDNCEIFPCPVLGTAEFTEMC---------------------------------- 1076

Query: 381  NPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVG-Y 439
             P G   +G    G  +S  G        +       +C NG CL T   Y C C  G Y
Sbjct: 1077 -PKG---KGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTY 1132

Query: 440  TQDVRGECIDVDECTS-SPCHHGDCVNIPGTYHCRCYPGFQATPTRQACV-------DVD 491
               V+ +C D+DEC   S C  G CVN  G+Y+C C        + + C+        ++
Sbjct: 1133 YDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIE 1192

Query: 492  ECIVSGGLC--HLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNG----- 544
            E  V   LC  HL        S + VC+         +  V      T   C+ G     
Sbjct: 1193 ETDVYQDLCWEHL--------SDEYVCS---------RPLVGKQTTYTECCCLYGEAWGM 1235

Query: 545  ---VC-LNEDGSFSCLCK---PGFLLAPGGHYCMDIDECQTP------------------ 579
               +C L +   ++ LC     G     G    +D  E  TP                  
Sbjct: 1236 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1295

Query: 580  -----GI---CVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTH 615
                 GI   C NG C   +  + C C  G  + T    CVD +
Sbjct: 1296 QAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVN 1339



 Score =  101 bits (251), Expect = 1e-20
 Identities = 128/550 (23%), Positives = 176/550 (32%), Gaps = 158/550 (28%)

Query: 57   PNVCGSR---------FHAYCCPGW------RTFPGRSQCVV-PICRRACGEGFCSQPN- 99
            P +CG +         FH  C  G+      RT     +CV   +C      GFC     
Sbjct: 884  PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCD---SHGFCDNTAG 940

Query: 100  --LCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHN 157
               C C  G  AP  G          C++   C   S +C + +   V G  +C     N
Sbjct: 941  SFRCLCYQGFQAPQDGQG--------CVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 992

Query: 158  G------GRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCC 211
                   G+C              P+ E+      C+  +        +     TK  CC
Sbjct: 993  QEYSPMTGQCRSRTSTDLDVDVDQPKEEKK----ECYYNLNDASLCDNVLAPNVTKQECC 1048

Query: 212  ATVGRAWGLPCELCPAQ------------------------------------------P 229
             T G  WG  CE+ P                                             
Sbjct: 1049 CTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQ 1108

Query: 230  HPCRRGFIPNIHTG----------------ACQDVDECQAVPGLCQGGSCVNMVGSFHCR 273
              C+ GF  N   G                 C D+DECQ  P  C  G CVN  GS++C 
Sbjct: 1109 EICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDGQCVNTEGSYNCF 1167

Query: 274  CPVGHRLSDSSAAC------------EDYRAGACFSVLFGGR-CAGDLAGHYTR-RQCCC 319
            C     L  S   C             D     C+  L     C+  L G  T   +CCC
Sbjct: 1168 CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCC 1227

Query: 320  DRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPAR 379
              G  W  G    LCP + S+++ QLC   +P+                          R
Sbjct: 1228 LYGEAW--GMQCALCPLKDSDDYAQLC--NIPVT------------------------GR 1259

Query: 380  LNPHGSDA------RGIPSLGPGNSNIGTATLNQTIDICRH---FTNLCLNGRCLPTPSS 430
              P+G DA      +  P   P    I    LN   ++        N C NGRC+     
Sbjct: 1260 RQPYGRDALVDFSEQYTPEADP--YFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEG 1317

Query: 431  YRCECNVGYTQDV-RGECIDVDECTS-----SPCHHGDCVNIPGTYHCRCYPGFQATPTR 484
            Y C+C  GY  D  +  C+DV+EC       S C +  C+N  G+Y C C PG+  +   
Sbjct: 1318 YTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKP 1377

Query: 485  QACVDVDECI 494
              C  ++  +
Sbjct: 1378 NYCTPLNTAL 1387



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 64/237 (27%), Positives = 102/237 (43%), Gaps = 47/237 (19%)

Query: 1487 TRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG-NPCELCPMANTTE-YRT 1544
            T+ G CF ET      G  C   +     +  CC ++G +WG N C+ CP   +   Y  
Sbjct: 228  TQLGRCFQET-----IGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQ 282

Query: 1545 LCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC- 1603
            +     G++    T   +DI+ECQ L G+C  G+C+NT GS++C C  G+        C 
Sbjct: 283  MMECLPGYKRVNNT-FCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340

Query: 1604 EDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQN 1663
             D    S   G C                   Y  V+ G  CM                +
Sbjct: 341  PDPPVISEEKGPC-------------------YRLVSSGRQCM----------------H 365

Query: 1664 ELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPL 1720
             L+ ++T+++CCCS  +G+AW   CE CP P +  ++ +C       ++ +H  +P+
Sbjct: 366  PLSVHLTKQLCCCS--VGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPI 420



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 180/769 (23%), Positives = 246/769 (31%), Gaps = 185/769 (24%)

Query: 68   CCPGWRTFPGR----SQCVVPICRRACGEGFCSQPN---LCTCADG-TLAPSCGVSRGSG 119
            C  G+R + G+     +C+ P     C  G CS      +C+C  G T  P     R   
Sbjct: 700  CTEGFRGWNGQCLDVDECLEP---NVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDID 756

Query: 120  CSVSCMNGGTCRGASCLCQKGYTGTVCGQP--------------------ICDRG-CHNG 158
                C  G  C    C   +G     CGQ                     +C  G C N 
Sbjct: 757  ---ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNT 813

Query: 159  GRCIGPNRCACVYGF----MGPQCE---------RDYRTGPCFGQVG------PEG---- 195
                G  +C C  G+    +G  CE            + G C    G      P+G    
Sbjct: 814  E---GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 870

Query: 196  ----------CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGAC 245
                      C+H   GL   +  C  T G      C         C++GF  +     C
Sbjct: 871  DNKTCQDINECEHP--GLCGPQGECLNTEG---SFHCV--------CQQGFSISADGRTC 917

Query: 246  QDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCA 305
            +D+DEC         G C N  GSF C C  G +       C D       S + G    
Sbjct: 918  EDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFC 977

Query: 306  GDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLG 365
             ++ G +     C D  + ++  P+   C  R S +        L +    P        
Sbjct: 978  ENVEGSFLC--VCADENQEYS--PMTGQCRSRTSTD--------LDVDVDQPKEEKKECY 1025

Query: 366  FGSNGMGPPLGPARLNPHGSDARGIPSLGPG---NSNIGTATLNQTIDICRHFTNLCLNG 422
            +  N     L    L P+ +      + G G   N  I    +  T +    FT +C  G
Sbjct: 1026 YNLNDAS--LCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE----FTEMCPKG 1079

Query: 423  R-CLPTPSSYRCECNVGYTQDVRGECI-DVDECT---SSPCHHGDCVNIPGTYHCRCYPG 477
            +  +P   S         + +  GE   D DEC       C +G C+N    Y C C  G
Sbjct: 1080 KGFVPAGES---------SSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQG 1130

Query: 478  FQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECAT 537
                P +  C D+DEC      C  G+CVNTEGS+ C C     L    K C+   E   
Sbjct: 1131 TYYDPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNE 1189

Query: 538  STMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQ 597
                     + E   +  LC           +  D   C  P   V    T TE    C 
Sbjct: 1190 Q--------IEETDVYQDLC---------WEHLSDEYVCSRP--LVGKQTTYTE----CC 1226

Query: 598  CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGT---------VTKSECCCANPD 648
            CL G A G    +C      S  Y  +    C  P  G          V  SE      D
Sbjct: 1227 CLYGEAWGMQCALCPLKD--SDDYAQL----CNIPVTGRRQPYGRDALVDFSEQYTPEAD 1280

Query: 649  HGF-------------GEPCQLCPAKDSAE-------FQALCSSGLGITTDGR---DINE 685
              F              E C +    ++         +   C  G  + T      D+NE
Sbjct: 1281 PYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNE 1340

Query: 686  CAL---DPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALN 731
            C        +C N  C N  GSY+C+C  GY        CT ++  ALN
Sbjct: 1341 CDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN-TALN 1388



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 46/165 (27%), Positives = 67/165 (40%), Gaps = 40/165 (24%)

Query: 1388 ECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDIN 1447
            EC  G+    ++  CQD++EC    +C  G C N  G +RC C  G+  D    +C    
Sbjct: 285  ECLPGYKRV-NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV--- 340

Query: 1448 ECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCS 1507
               DP                                +    G C+        SG  C 
Sbjct: 341  --PDP------------------------------PVISEEKGPCYRLV----SSGRQCM 364

Query: 1508 AEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGF 1552
              + V +T+  CCCS+G+AWG  CE CP+  T  ++ +CPGG G+
Sbjct: 365  HPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGY 409



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 42/127 (33%), Positives = 68/127 (53%), Gaps = 12/127 (9%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGG-GRGWG-PRCELCPL-PGTSAYRKLCPHG 2354
            G CF E + + C     +   +++ E CCG  G  WG  +C+ CP  P    Y ++    
Sbjct: 231  GRCFQETIGSQC---GKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECL 287

Query: 2355 SGYTAEG----RDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCL-DMDEC 2409
             GY        +D++EC+ L  +C +GEC+N++GS+RC C+ G+ PD T ++C+ D    
Sbjct: 288  PGYKRVNNTFCQDINECQ-LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVI 346

Query: 2410 SQVPKPC 2416
            S+   PC
Sbjct: 347  SEEKGPC 353



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 19/108 (17%)

Query: 2565 QCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYS 2624
            Q  + NEC ++P  CG+  C N    + C+C  G+ F +    C ++DEC   +  CS  
Sbjct: 545  QVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQG 604

Query: 2625 -CANTPGGFLCGCPQGYFRA------------------GQGHCVSGLG 2653
             C NT G FLC CP G+  +                  G+GHCV+ +G
Sbjct: 605  RCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVG 652



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 61/219 (27%), Positives = 82/219 (37%), Gaps = 38/219 (17%)

Query: 76  PGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCR---G 132
           PG  QCV       C EGF      C   D  L P+            C NG        
Sbjct: 692 PGSYQCV------PCTEGFRGWNGQCLDVDECLEPNV-----------CANGDCSNLEGS 734

Query: 133 ASCLCQKGYTGTVCGQPICDRG-CHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQV 191
             C C KGYT T   +   D   C  G  C+   +C    G     C + Y+      Q 
Sbjct: 735 YMCSCHKGYTRTPDHKHCRDIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQLSAAKDQC 793

Query: 192 GP-EGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDE 250
              + CQH+    +C    C  T G      C         C +G+  +     C+D++E
Sbjct: 794 EDIDECQHRH---LCAHGQCRNTEG---SFQCV--------CDQGYRASGLGDHCEDINE 839

Query: 251 CQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED 289
           C     +CQ G C+N  GS+ C CP G +L D+   C+D
Sbjct: 840 CLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK-TCQD 877



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 5/115 (4%)

Query: 913  RLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGV-ECEACPDPESLEFASLCPRGLG 971
            +L  CF      +CG  LPG  + + CC ++G  WG  +C+ CP   S    +     L 
Sbjct: 229  QLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLP 288

Query: 972  FASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNC 1026
               R       F +D+NEC++  G+C +G C NT+GS+ C C  GF  D    +C
Sbjct: 289  GYKR---VNNTFCQDINECQL-QGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 86/370 (23%), Positives = 120/370 (32%), Gaps = 93/370 (25%)

Query: 98  PNLC--TCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGC 155
           P++C  TC  G+   SC   +G+  ++   NG     A  L    +   +C  P     C
Sbjct: 32  PSICKVTCTKGSCQNSC--EKGNTTTLISENG---HAADTLTATNFRVVICHLP-----C 81

Query: 156 HNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQH-QLTGLVCTKALCCATV 214
            NGG+C   ++C C   F G  C+      P  G   P+  QH Q  G    KAL    +
Sbjct: 82  MNGGQCSSRDKCQCPPNFTGKLCQI-----PVHGASVPKLYQHSQQPG----KALGTHVI 132

Query: 215 GRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDEC-------------------QAVP 255
                LP  +   Q    +  F PNI     +   E                    +A P
Sbjct: 133 HSTHTLPLTVTSQQGVKVK--FPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQP 190

Query: 256 GLCQ---GGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHY 312
           G  Q    G  V    + H        +          + G CF    G +C   L G  
Sbjct: 191 GQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLS 250

Query: 313 TRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG 372
            +  CC   G  W      + CP + S        Q +  LPG+                
Sbjct: 251 KQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYN---QMMECLPGY---------------- 290

Query: 373 PPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYR 432
                 R+N                      T  Q I+ C+    +C NG CL T  SYR
Sbjct: 291 -----KRVN---------------------NTFCQDINECQ-LQGVCPNGECLNTMGSYR 323

Query: 433 CECNVGYTQD 442
           C C +G+  D
Sbjct: 324 CTCKIGFGPD 333



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 39/117 (33%), Positives = 57/117 (48%), Gaps = 7/117 (5%)

Query: 2012 TRQSFCFTRFEAGKCSVPKAF-NTTKTRCCCSKRPGEGWG-DPCELCPQEGSA-AFQELC 2068
            T+   CF      +C   KA    +K   CC    G  WG + C+ CP++ S   + ++ 
Sbjct: 228  TQLGRCFQETIGSQCG--KALPGLSKQEDCCGT-VGTSWGFNKCQKCPKKPSYHGYNQMM 284

Query: 2069 PFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCV 2125
                G     +   +D+NEC +  GVC NG C+NT GS+RC C  G+  D T  +CV
Sbjct: 285  ECLPGYKRVNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 5/124 (4%)

Query: 1653 CFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWN-RPCEACPTPISPDYQILCGNQAPGFL 1711
            CF+   G+   +    ++++  CC   +G +W    C+ CP   S           PG+ 
Sbjct: 233  CFQETIGSQCGKALPGLSKQEDCCG-TVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYK 291

Query: 1712 TDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLAC-EDVDECGSR 1770
              ++     DI+EC ++  +C NG C+N +GS+RC C  GF  +    +C  D       
Sbjct: 292  R-VNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEE 349

Query: 1771 ESPC 1774
            + PC
Sbjct: 350  KGPC 353



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 53/202 (26%), Positives = 80/202 (39%), Gaps = 37/202 (18%)

Query: 2464 TVGAFTCRCPPGFTQHHQAC------FDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGF 2517
            T+G+   +  PG ++    C      +  ++C   P     HG+      +   EC  G+
Sbjct: 237  TIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGY------NQMMECLPGY 290

Query: 2518 TLVSSGHGCEDVNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSP 2576
              V++   C+D+NEC     C +G C N +G YRC+C  GF     ++ CV +      P
Sbjct: 291  KRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPD------P 343

Query: 2577 PTCGSAS---CRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRR-GPCSYSCANTPG-- 2630
            P          R    G +C+ P      + L  C       G+  GP    C   PG  
Sbjct: 344  PVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCS-----VGKAWGPHCEKCP-LPGTA 397

Query: 2631 GFLCGCPQGYFRAGQGHCVSGL 2652
             F   CP      G G+ VSG+
Sbjct: 398  AFKEICP-----GGMGYTVSGV 414



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 1/57 (1%)

Query: 1790 KCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCM 1846
            +C  GYK      C   NEC ++  VC +G+C++T GSY C C  GF      + C+
Sbjct: 285  ECLPGYKRVNNTFCQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 4/66 (6%)

Query: 2579 CGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC---AGRRGPC-SYSCANTPGGFLC 2634
            C +  C     G+ C C  G+  D A   C +V+EC     R   C +  C NT G + C
Sbjct: 1306 CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKC 1365

Query: 2635 GCPQGY 2640
             C  GY
Sbjct: 1366 LCLPGY 1371



 Score = 39.3 bits (90), Expect = 0.055
 Identities = 45/203 (22%), Positives = 68/203 (33%), Gaps = 51/203 (25%)

Query: 2399 TATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQ 2458
            T  T    ++C + PK  ++   N     +  C  GY    +   C+D++EC  +     
Sbjct: 258  TVGTSWGFNKCQKCPKKPSYHGYNQ----MMECLPGYK-RVNNTFCQDINECQLQGVCPN 312

Query: 2459 FLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFT 2518
              C+NT+G++ C C  GF                 GP      C   P     E    + 
Sbjct: 313  GECLNTMGSYRCTCKIGF-----------------GPDPTFSSCVPDPPVISEEKGPCYR 355

Query: 2519 LVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPT 2578
            LVSSG             +C H     L    C C  G        +C          P 
Sbjct: 356  LVSSG------------RQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC----------PL 393

Query: 2579 CGSASCRNTLGGFRCVCPSGFDF 2601
             G+A+       F+ +CP G  +
Sbjct: 394  PGTAA-------FKEICPGGMGY 409



 Score = 39.3 bits (90), Expect = 0.055
 Identities = 18/49 (36%), Positives = 22/49 (44%), Gaps = 1/49 (2%)

Query: 2110 ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEP 2158
            EC  GY        C D +EC +   C  G C N +G + C C  GF P
Sbjct: 285  ECLPGYKR-VNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGP 332



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 22/96 (22%)

Query: 1724 ECGE-IPAICANGICINQIGSF----RCE-CP---AGFNYNSILLA-----------CED 1763
            +CG+ +P +     C   +G+     +C+ CP   +   YN ++             C+D
Sbjct: 241  QCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQD 300

Query: 1764 VDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSP 1799
            ++EC   +  C  N +C+N  GSYRC C  G+   P
Sbjct: 301  INEC-QLQGVCP-NGECLNTMGSYRCTCKIGFGPDP 334



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 8/71 (11%)

Query: 2413 PKPCTFLCKNTKGSFLCSCPRGY---LLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469
            P  C   C  TKGS   SC +G    L+ E+G     L     R   C   C+N     +
Sbjct: 32   PSICKVTC--TKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSS 89

Query: 2470 ---CRCPPGFT 2477
               C+CPP FT
Sbjct: 90   RDKCQCPPNFT 100



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%)

Query: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD 1315
            C  GY  R   T C D++EC++ G     +  CLN  GS+ C C  G+  D
Sbjct: 286  CLPGYK-RVNNTFCQDINECQLQG--VCPNGECLNTMGSYRCTCKIGFGPD 333


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  504 bits (1297), Expect = e-142
 Identities = 291/799 (36%), Positives = 385/799 (48%), Gaps = 108/799 (13%)

Query: 996  LCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTCVNTPGSFECE 1054
            +C  GTC N    + C C+ G+ L   +  CTD +EC   P  C G+G C+N  GS+ C 
Sbjct: 855  VCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCF 912

Query: 1055 CFPGYESGFM-LMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACED 1113
            C+PGY        + C D++EC + P +C GG CTNT+GSY C+C  G+ +  KG  C+D
Sbjct: 913  CYPGYTLATSGATQECQDINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGH-CQD 970

Query: 1114 IDECSLSDGLCPHGQCVNVIGAFQC-SCHAGFQSTPDRQGCVDINECRVQNGGCDVHCIN 1172
            I+EC    G CP G+CVN  G++ C +C  G++       CVD+NEC          C N
Sbjct: 971  INECR-HPGTCPDGRCVNSPGSYTCLACEEGYRGQSG--SCVDVNECLTPGVCAHGKCTN 1027

Query: 1173 TEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRC-LCYDGFMATP 1231
             EGS+RCSC QGY +  D + C DVDEC      C  G C N  G   C  C +G+    
Sbjct: 1028 LEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFACSACENGYWVNE 1086

Query: 1232 DMRTCVDVDECDLNPHICLHGDCENTKGSFVCH-CQLGYMVRKGATGCSDVDECEVGGHN 1290
            D   C D+DEC   P +C  G C NT GSF C  C  GY        C DVDECE    +
Sbjct: 1087 DGTACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSS 1145

Query: 1291 CDSHASCLNIPGSFSCRCLPGW-VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTC 1349
            C     C N  GS+ C C  G+ + +G  C D++EC+ +EH C+P G+CLN  GS+ C C
Sbjct: 1146 CLG-GECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEH-CAPHGECLNSHGSFFCLC 1203

Query: 1350 RQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDE 1407
              GF  A  G  C+D DECA   D C  G C+N  G + C CE GF P+ +   C D+DE
Sbjct: 1204 APGFVSAEGGTSCQDVDECA-TTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDE 1262

Query: 1408 CAQGN--LCAFGSCENLPGMFRCI--CNGGYELDRGGGNCTDINECADPVNC-INGVCIN 1462
            C      +C    CEN PG +RC+  C  G+ +    G+C DI+ECA+   C  +G C N
Sbjct: 1263 CEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECANDTMCGSHGFCDN 1321

Query: 1463 TPGSYLCSCPQDFELNPSGVGCVDTR----------AGNCF-------------LETHD- 1498
            T GS+ C C Q FE++PSG  CVD            A  C              LE +D 
Sbjct: 1322 TDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDA 1381

Query: 1499 -------RGDSGIS---------------------------CSAEIGVGVTRASCCCSLG 1524
                   RG  G S                           CS+ +G   T+A CCC+ G
Sbjct: 1382 QEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQG 1441

Query: 1525 RAWGNPCELCPMANTTEYRTLCPGGEGFQPNRIT-----VILEDIDECQEL-PGLCQGGD 1578
             +WG+ C+LCP  ++ E+  +CP G+G+ P          +  D DEC    PGLC  G 
Sbjct: 1442 ASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGR 1501

Query: 1579 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ 1638
            C+NT   + C C PG+H     + CED DEC   +  C  G C NT G++ C C      
Sbjct: 1502 CLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENGECVNTEGSFHCFCSPPLTL 1559

Query: 1639 VNGGNNCM------------DMRKSVCFRHY-NGTCQNEL-AFNVTRKMCCCSYNIGQAW 1684
                  CM            D+   +C++   N  C   L     T   CCC    G+AW
Sbjct: 1560 DLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCC--QDGEAW 1617

Query: 1685 NRPCEACPTPISPDYQILC 1703
            ++ C  CP   S  Y  LC
Sbjct: 1618 SQQCALCPPRSSEVYAQLC 1636



 Score =  449 bits (1156), Expect = e-125
 Identities = 345/1120 (30%), Positives = 462/1120 (41%), Gaps = 225/1120 (20%)

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLP-CELCPAQPHP---------CRR 234
            G C+       C + L  L  T+  CC +VG  WG+  C  CP +P           C +
Sbjct: 552  GRCYLNTVNGQCANPLLELT-TQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQ 610

Query: 235  GFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA-- 292
            G+   ++   CQD++EC  + GLC+   CVN  GS+ C C  G  L  S + C   +A  
Sbjct: 611  GY-KRLNLTHCQDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAIS 668

Query: 293  ---GACFSVLFGGRCAGDLAGHYTRRQCCCDR-GRCWAAG----PVP------ELCPPRG 338
               G C+  L  G C   LA   T++ CCC R G+ W +     P+P      E+C P G
Sbjct: 669  MLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREIC-PAG 727

Query: 339  SNEFQQLCAQRLPLLPGHPGLF---PGLLGFGSNGMGPPLGPARLNP------HGSDARG 389
                      RL +           P   G  S+G  P  GPA   P         +A  
Sbjct: 728  HGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALP--GPAERQPLRVVTDTWLEAGT 785

Query: 390  IPSLGPGNSNIGTATLNQT----------------------------------------- 408
            IP    G+S  G  T + T                                         
Sbjct: 786  IPD--KGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP 843

Query: 409  -IDICRH-FTNLCLNGRCLPTPSSYRCECNVGY-TQDVRGECIDVDECTSSPCH-HGDCV 464
             ID C    TN+C  G C+  P  YRC C+ GY     +  C D +EC   PC   G C+
Sbjct: 844  GIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI 903

Query: 465  NIPGTYHCRCYPGF--QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
            N  G+Y C CYPG+    +   Q C D++EC    G+C  G+C NTEGS+ C C+ G+ +
Sbjct: 904  NRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIM 962

Query: 523  SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCL-CKPGFLLAPGGHYCMDIDECQTPGI 581
               G +C D NEC     C +G C+N  GS++CL C+ G+    G   C+D++EC TPG+
Sbjct: 963  VRKG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGS--CVDVNECLTPGV 1019

Query: 582  CVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTH---VRSTCYGAIEKGSCARPFPGTVT 638
            C +G CTN EGSFRC C  G  V +D + C D      R++C      G C        T
Sbjct: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASC----PTGLCLN------T 1069

Query: 639  KSECCCANPDHGF--GEPCQLCPAKDSAEFQALCSSGLGITTDG---------------- 680
            +    C+  ++G+   E    C   D   F  +C SG+   T G                
Sbjct: 1070 EGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPL 1129

Query: 681  ----RDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCD 736
                 D++EC      C  G C+N  GSY+C+C  G++  A+G  C DV+EC        
Sbjct: 1130 GDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAP 1188

Query: 737  NGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSS-PCVSGVCRNLAGSYTCKCGPGS 795
            +G C NS GS+ C C PGF   +    C+DVDEC ++ PCV G C N  GS+ C C  G 
Sbjct: 1189 HGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGF 1248

Query: 796  RLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPAC 855
            +  P    C+D              CE            C T          RC +   C
Sbjct: 1249 QPSPESGECVDI-----------DECE------DYGDPVCGTWKCENSPGSYRCVL--GC 1289

Query: 856  ARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDV--- 912
              GF       C D++EC +      +G C NT GSFRC C +G  +  SG  CVDV   
Sbjct: 1290 QPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNEC 1349

Query: 913  -------------RLEPCFL--------RWDEDE-----------------CGVTLPGKY 934
                          +E  FL         +D  E                  G   P   
Sbjct: 1350 ELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPT 1409

Query: 935  RMDV----------------------CCCSIGAVWGVECEACPDPESLEFASLCPRGLGF 972
            RMD                       CCC+ GA WG  C+ CP  +S EF+ +CP G G+
Sbjct: 1410 RMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGY 1469

Query: 973  ASRD--FLSGRPFYKDVNECKVF-PGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDI 1029
               +  +  G+  Y D +EC +F PGLC +G C NTV  + C C  GF  DA  + C D 
Sbjct: 1470 IPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDH 1529

Query: 1030 DECRISPDL-CGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARD--PLLCRGGT 1086
            DEC+   DL C  G CVNT GSF C C P      +  + CM+      D          
Sbjct: 1530 DECQ---DLACENGECVNTEGSFHCFCSPPLTLD-LSQQRCMNSTSSTEDLPDHDIHMDI 1585

Query: 1087 CTNTDGSYKCQCP-PGHELTAKGTACEDIDECSLSDGLCP 1125
            C     +  C  P  GH  T     C+D +  S    LCP
Sbjct: 1586 CWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCP 1625



 Score =  447 bits (1151), Expect = e-125
 Identities = 330/1108 (29%), Positives = 460/1108 (41%), Gaps = 232/1108 (20%)

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG----NPCELCPMANTTEYRTL 1545
            G C+L T +       C+  +    T+  CC S+G  WG     PC   P +   E   L
Sbjct: 552  GRCYLNTVNG-----QCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQL 606

Query: 1546 -CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICE 1604
             CP  +G++   +T   +DI+EC  L GLC+  +CVNT GS+ C C PG  L      C 
Sbjct: 607  ECP--QGYKRLNLTHC-QDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662

Query: 1605 DIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNE 1664
                 S   G+     CY +LG  TC  P                               
Sbjct: 663  SDKAISMLQGL-----CYRSLGPGTCTLP------------------------------- 686

Query: 1665 LAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILC--------------------- 1703
            LA  +T+++CCCS  +G+AW   CE CP P +  ++ +C                     
Sbjct: 687  LAQRITKQICCCS-RVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAE 745

Query: 1704 -----------GNQAPGFLTDIHTGKPLDID-----ECGEIPAICANGICINQIGSFRCE 1747
                       G ++ G L      +PL +      E G IP          Q+ +    
Sbjct: 746  EEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPD--KGDSQAGQVTTSVTH 803

Query: 1748 CPAGFNYNSILLACEDVDECGSRESPCQQNAD---CINIPGSYRCKCTRGYKLSPGGACV 1804
             PA    N+      +      +E     + D    ++ PG  RC           GA  
Sbjct: 804  APAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRC---------AAGA-- 852

Query: 1805 GRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPC-GNGTCKN 1863
                     NVC  G C++    Y C+C  G+Q    Q  C D +EC R PC G G C N
Sbjct: 853  --------TNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904

Query: 1864 IIGSYNCLCFPGFVVTHNG---DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
             +GSY+C C+PG+ +  +G   +C D +EC      VC  G C NT GS+HC C  G+ +
Sbjct: 905  RVGSYSCFCYPGYTLATSGATQECQDINECEQ--PGVCSGGQCTNTEGSYHCECDQGYIM 962

Query: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCI-CPPGFQVQSDHCIDIDECSEEPNL 1979
               G +C D NEC    GTC  G C N  GS+ C+ C  G++ QS  C+D++EC   P +
Sbjct: 963  VRKG-HCQDINECRH-PGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECL-TPGV 1019

Query: 1980 CLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRC 2039
            C  G CTN  GSF+C C  G+ ++ +   C D  +  C +R     C      NT  +  
Sbjct: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDE--CASR---ASCPTGLCLNTEGSFA 1074

Query: 2040 CCSKRPGEGWGDPCELCPQEGSAAFQELCPFG---------------HGAVPGP-DDSRE 2083
            C +   G    +    C      AF  +CP G                G  P P  DS E
Sbjct: 1075 CSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE 1134

Query: 2084 DVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCG-QGTCT 2142
            DV+EC +    C  G C NT GS++C CP G+ L   G  C D +EC     C   G C 
Sbjct: 1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECL 1193

Query: 2143 NVIGGFECACADGF---EPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLR 2199
            N  G F C CA GF   E G   +C+D+DEC+         C NTEGS+ C C  G+   
Sbjct: 1194 NSHGSFFCLCAPGFVSAEGG--TSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPS 1251

Query: 2200 EDGAMCRDVDECAD-GQQDCHARGMECKNLIGTFACV--CPPGMRPLPGSGEGCTDDNEC 2256
             +   C D+DEC D G   C     +C+N  G++ CV  C PG    P     C D +EC
Sbjct: 1252 PESGECVDIDECEDYGDPVCGT--WKCENSPGSYRCVLGCQPGFHMAPNG--DCIDIDEC 1307

Query: 2257 HAQPDLC-VNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ-----GPCFAEVLQTM-- 2308
             A   +C  +G C NT GSFRC CD+GF+ SP+  +C D+ +       C A + + +  
Sbjct: 1308 -ANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEG 1366

Query: 2309 -------------------CRSLSSSSEAVTRA--------------------------- 2322
                               CR   +  ++++ A                           
Sbjct: 1367 SFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSV 1426

Query: 2323 --------ECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGY-TAEG---------RDV 2364
                    ECCC  G  WG  C+LCP   ++ + ++CP G GY   EG          D 
Sbjct: 1427 LGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDA 1486

Query: 2365 DECRMLA-HLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNT 2423
            DEC +    LC +G C+N++  + C C  G+  DA+   C D DEC  +       C NT
Sbjct: 1487 DECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACE-NGECVNT 1545

Query: 2424 KGSFLCSCPRGYLLEEDGRTCKDLDECT 2451
            +GSF C C     L+   + C +    T
Sbjct: 1546 EGSFHCFCSPPLTLDLSQQRCMNSTSST 1573



 Score =  437 bits (1124), Expect = e-122
 Identities = 315/1057 (29%), Positives = 421/1057 (39%), Gaps = 216/1057 (20%)

Query: 1281 VDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFE--CHDLDECVSQEHRCSPRGDC 1338
            +D C  G  N     +C+N+P  + C C PG+     +  C D +EC+     C  +G C
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRC 902

Query: 1339 LNVPGSYRCTCRQGF----AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFD 1394
            +N  GSY C C  G+    +G    C+D +EC E   +C  GQC N  G Y CEC+ G+ 
Sbjct: 903  INRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYI 961

Query: 1395 PTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCI-CNGGYELDRG-GGNCTDINECADP 1452
                   CQD++EC     C  G C N PG + C+ C  GY   RG  G+C D+NEC  P
Sbjct: 962  MVRKGH-CQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY---RGQSGSCVDVNECLTP 1017

Query: 1453 VNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGV 1512
              C +G C N  GS+ CSC Q +E+     GC D                   C++    
Sbjct: 1018 GVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD----------------ECAS---- 1057

Query: 1513 GVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGE-GFQPNRITVILEDIDECQELP 1571
               RASC          P  LC     TE    C   E G+  N      ED+DEC   P
Sbjct: 1058 ---RASC----------PTGLCL---NTEGSFACSACENGYWVNEDGTACEDLDECA-FP 1100

Query: 1572 GLCQGGDCVNTFGSFQC-ECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTC 1630
            G+C  G C NT GSF C +C  GY  S     CED+DEC      C  G C NT+G+Y C
Sbjct: 1101 GVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQC 1160

Query: 1631 VCPAEYLQVNGGNNCMDMRKSVCFRHY--NGTCQNELAFNVTRKMCCCSYNIGQAWNRPC 1688
            +CP  + Q+  G  C D+ + +   H   +G C N          C C            
Sbjct: 1161 LCPQGF-QLANGTVCEDVNECMGEEHCAPHGECLNSHG----SFFCLC------------ 1203

Query: 1689 EACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCEC 1748
                              APGF++        D+DEC      C  G C+N  GSF C C
Sbjct: 1204 ------------------APGFVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFNCLC 1244

Query: 1749 PAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCK--CTRGYKLSPGGACVGR 1806
              GF  +     C D+DEC     P      C N PGSYRC   C  G+ ++P G C+  
Sbjct: 1245 ETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDI 1304

Query: 1807 NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQ--PCGNGTCKNI 1864
            +EC       SHG C +T+GS+ CLC +GF+ S     C+D++EC+     CG   C+N+
Sbjct: 1305 DECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENV 1364

Query: 1865 IGSYNCLCFPGFV-----------------------------VTHNGDCVDFDE----CT 1891
             GS+ CLC                                       DC    +    C+
Sbjct: 1365 EGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCS 1424

Query: 1892 TLVGQVCRFGHCLNTAGSFH------CLCQDGFELTA---DGKNCV-------------- 1928
            +++G+      C  T G+        C  +D  E +     GK  +              
Sbjct: 1425 SVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYT 1484

Query: 1929 DTNECLSLA-GTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTC 1985
            D +EC+    G C  G C N    + C+C PGF   + H  C D DEC +    C  G C
Sbjct: 1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENGEC 1542

Query: 1986 TNSPGSFQCLCPPGFVLSDNGHRCFDTRQS------------FCFTRFEAGKCSVP-KAF 2032
             N+ GSF C C P   L  +  RC ++  S             C+ +     CS P +  
Sbjct: 1543 VNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGH 1602

Query: 2033 NTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPF---------------GHGAVPG 2077
             TT T CCC  + GE W   C LCP   S  + +LC                 G+   PG
Sbjct: 1603 RTTYTECCC--QDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPG 1660

Query: 2078 PDDSREDVNECAENP--------GVCTNGVCVNTDGSFRCECPF---------------- 2113
            PDD    +      P                 NT G      P                 
Sbjct: 1661 PDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVA 1720

Query: 2114 GYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFE-PGLMMTCEDIDEC-S 2171
             +     G   +  +EC + + C  G C  V  G+ C C +GF+     M C D++EC  
Sbjct: 1721 SHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDD 1780

Query: 2172 LN--PLLCAF-RCHNTEGSYLCTCPAGYTLREDGAMC 2205
            LN   +LC    C NTEGSY C C  GY        C
Sbjct: 1781 LNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817



 Score =  418 bits (1074), Expect = e-116
 Identities = 328/1049 (31%), Positives = 435/1049 (41%), Gaps = 194/1049 (18%)

Query: 1722 IDECGE-IPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADC 1780
            ID C      +C  G C+N    +RC C  G+  +     C D +EC     PC+    C
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRC 902

Query: 1781 INIPGSYRCKCTRGYKLSPGGA---CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQ 1837
            IN  GSY C C  GY L+  GA   C   NEC + P VCS G C +TEGSY C C +G+ 
Sbjct: 903  INRVGSYSCFCYPGYTLATSGATQECQDINECEQ-PGVCSGGQCTNTEGSYHCECDQGY- 960

Query: 1838 ASADQTLCMDIDECDRQP--CGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVG 1895
                +  C DI+EC R P  C +G C N  GSY CL         +G CVD +EC T   
Sbjct: 961  IMVRKGHCQDINEC-RHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLT--P 1017

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRC- 1954
             VC  G C N  GSF C C+ G+E+T+D K C D +EC S A +C  G C N EGSF C 
Sbjct: 1018 GVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTGLCLNTEGSFACS 1076

Query: 1955 ICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSPGSFQCL-CPPGFVLSDNGHRCFD 2011
             C  G+ V  D   C D+DEC+  P +C  G CTN+ GSF C  C  G+  S  G  C D
Sbjct: 1077 ACENGYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCED 1135

Query: 2012 TR-----QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQE 2066
                   QS C      G+C      NT  +  C              LCPQ    A   
Sbjct: 1136 VDECEDPQSSCL----GGECK-----NTVGSYQC--------------LCPQGFQLANGT 1172

Query: 2067 LCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
            +C              EDVNEC        +G C+N+ GSF C C  G+     G +C D
Sbjct: 1173 VC--------------EDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218

Query: 2127 TDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM-TCEDIDECSL--NPLLCAFRCHN 2183
             DEC+   PC  G C N  G F C C  GF+P      C DIDEC    +P+   ++C N
Sbjct: 1219 VDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCEN 1278

Query: 2184 TEGSYLCT--CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMR 2241
            + GSY C   C  G+ +  +G  C D+DECA+    C + G  C N  G+F C+C  G  
Sbjct: 1279 SPGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTM-CGSHGF-CDNTDGSFRCLCDQGFE 1335

Query: 2242 PLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQ----------------- 2284
              P SG  C D NEC     +C    C N  GSF C C    +                 
Sbjct: 1336 ISP-SGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQ 1394

Query: 2285 -----------PSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWG 2333
                       P+PT  +C+  ++G          C S+   +   T+AECCC  G  WG
Sbjct: 1395 SMSEAPTGDHAPAPTRMDCYSGQKG-------HAPCSSVLGRN--TTQAECCCTQGASWG 1445

Query: 2334 PRCELCPLPGTSAYRKLCPHGSG--------------YT-------------AEGR---- 2362
              C+LCP   ++ + ++CP G G              YT               GR    
Sbjct: 1446 DACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNT 1505

Query: 2363 ----------------------DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2400
                                  D DEC+ LA  C +GEC+N+ GSF C C    T D + 
Sbjct: 1506 VPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENGECVNTEGSFHCFCSPPLTLDLSQ 1563

Query: 2401 TTCLDMDECSQ-VPKPCTFL--CKNTKGSFLCSCP-RGYLLEEDGRTCKDLDECTSRQHN 2456
              C++    ++ +P     +  C     + +CS P RG+        C+D  E  S+Q  
Sbjct: 1564 QRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQD-GEAWSQQ-- 1620

Query: 2457 CQFLCV---NTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGS-FRCE 2512
            C  LC    + V A  C       +              PGP   H   +   G+ F   
Sbjct: 1621 CA-LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNY 1679

Query: 2513 CHQGFTLV------SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQC 2566
                 T+       ++GH  +     + P +      + +  +    P GF       + 
Sbjct: 1680 LGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHP-EPPAGF-------EG 1731

Query: 2567 VDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGP---CSY 2623
            +   EC +    C +  C     G+ C C  GF  D A   C +V+EC    GP   C +
Sbjct: 1732 LQAEECGILNG-CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH 1790

Query: 2624 S-CANTPGGFLCGCPQGYF-RAGQGHCVS 2650
              C NT G + C C  GY   AG  HC +
Sbjct: 1791 GYCENTEGSYRCHCSPGYVAEAGPPHCTA 1819



 Score =  416 bits (1068), Expect = e-115
 Identities = 293/905 (32%), Positives = 372/905 (41%), Gaps = 196/905 (21%)

Query: 725  VDECALNSL-LCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVS-GVCRN 782
            +D CA  +  +C  G C N P  Y C C PG+        C D +ECL  PC   G C N
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904

Query: 783  LAGSYTCKCGPGSRLDPSGTF--CLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840
              GSY+C C PG  L  SG    C D  +           CE    G     +C  T G+
Sbjct: 905  RVGSYSCFCYPGYTLATSGATQECQDINE-----------CEQ--PGVCSGGQCTNTEGS 951

Query: 841  AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRC-ECPEG 899
                    CE    C +G+  +    C D+NEC   PG CP+GRCVN+ GS+ C  C EG
Sbjct: 952  Y------HCE----CDQGYIMVRKGHCQDINECRH-PGTCPDGRCVNSPGSYTCLACEEG 1000

Query: 900  LMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPES 959
                +    CVDV           +EC    PG        C+ G    +E         
Sbjct: 1001 YRGQSGS--CVDV-----------NEC--LTPG-------VCAHGKCTNLEGS------- 1031

Query: 960  LEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC-ACAGGFA 1018
              F   C +G      +  S     +DV+EC      C  G C NT GSF C AC  G+ 
Sbjct: 1032 --FRCSCEQGY-----EVTSDEKGCQDVDEC-ASRASCPTGLCLNTEGSFACSACENGYW 1083

Query: 1019 LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFEC-ECFPGYESGFMLMKNCMDVDECAR 1077
            ++     C D+DEC   P +C  G C NT GSF C +C  GY     L  +C DVDEC  
Sbjct: 1084 VNEDGTACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPS-PLGDSCEDVDECED 1141

Query: 1078 DPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQ 1137
                C GG C NT GSY+C CP G +L A GT CED++EC   +   PHG+C+N  G+F 
Sbjct: 1142 PQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFF 1200

Query: 1138 CSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADV 1197
            C C  GF S      C D++EC   +     HC+NTEGS+ C C  G+   P+   C D+
Sbjct: 1201 CLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDI 1260

Query: 1198 DECEE-NPRVCDQGHCTNMPGGHRCL--CYDGFMATPDMRTCVDVDECDLNPHICLHGDC 1254
            DECE+    VC    C N PG +RC+  C  GF   P+   C+D+DEC  +     HG C
Sbjct: 1261 DECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPN-GDCIDIDECANDTMCGSHGFC 1319

Query: 1255 ENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVG 1314
            +NT GSF C C  G+ +      C DV+ECE+    C + A C N+ GSF C C      
Sbjct: 1320 DNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGA-ALCENVEGSFLCLC------ 1372

Query: 1315 DGFECHDLDECVSQEHRCSPRG-------------------------------DCLNVPG 1343
                  DL+E  +QE  C PRG                                C +V G
Sbjct: 1373 ----ASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLG 1428

Query: 1344 ----SYRCTCRQGF----------------------AGDGF------------FCEDRDE 1365
                   C C QG                       +G G+               D DE
Sbjct: 1429 RNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADE 1488

Query: 1366 CA-ENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPG 1424
            C      LC NG+CLN   GY C C  GF     H+ C+D DEC Q   C  G C N  G
Sbjct: 1489 CVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC-QDLACENGECVNTEG 1547

Query: 1425 MFRCICNGGYELDRGGGNCTDINECAD--PVNCIN-GVCINTPGSYLCSCPQDFELNPSG 1481
             F C C+    LD     C +     +  P + I+  +C     + +CS P         
Sbjct: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLR------- 1600

Query: 1482 VGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTE 1541
                                         G   T   CCC  G AW   C LCP  ++  
Sbjct: 1601 -----------------------------GHRTTYTECCCQDGEAWSQQCALCPPRSSEV 1631

Query: 1542 YRTLC 1546
            Y  LC
Sbjct: 1632 YAQLC 1636



 Score =  413 bits (1061), Expect = e-114
 Identities = 319/1033 (30%), Positives = 419/1033 (40%), Gaps = 175/1033 (16%)

Query: 502  LGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGF 561
            LGRC     + QC  N   EL+     C         T+C    C     S   + + G 
Sbjct: 551  LGRCYLNTVNGQCA-NPLLELTTQEDCCGSVGAFWGVTLCAP--CPPRPAS--PVIENGQ 605

Query: 562  LLAPGGH------YCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVD-- 613
            L  P G+      +C DI+EC T G+C +  C NT GS+ C C  GL +      CV   
Sbjct: 606  LECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665

Query: 614  --THVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCS 671
              + ++  CY ++  G+C  P    +TK  CCC+     +G  C+ CP   +  F+ +C 
Sbjct: 666  AISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICP 725

Query: 672  SGLGITTDGRDI---------NECALDPEVCANGVCENLRG-----SYRCVCNLGYEAGA 717
            +G G T    DI          E A  P          L G       R V +   EAG 
Sbjct: 726  AGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGT 785

Query: 718  SGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPP----GFHFWQDTEI--CKDVDECL 771
                          S+     W        + + PP    G    Q+ ++    DV   L
Sbjct: 786  IPDKGDSQAGQVTTSVTHAPAWVTG-----NATTPPMPEQGIAEIQEEQVTPSTDVLVTL 840

Query: 772  SSP------------CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDST---------KG 810
            S+P            C  G C NL   Y C C PG +L PS  +C D           KG
Sbjct: 841  STPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKG 900

Query: 811  TCWLKIQESRC----EVNLQGASLRSEC-----CATLGAAWGSPCERCE--IDPACARGF 859
             C  ++    C       L  +    EC     C   G   G  C   E      C +G+
Sbjct: 901  RCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGY 960

Query: 860  ARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRC-ECPEGLMLDASGRLCVDVR--LEP 916
              +    C D+NEC   PG CP+GRCVN+ GS+ C  C EG    +    CVDV   L P
Sbjct: 961  IMVRKGHCQDINECR-HPGTCPDGRCVNSPGSYTCLACEEGYRGQSGS--CVDVNECLTP 1017

Query: 917  CFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGL------ 970
                    +C   L G +R   C C  G     + + C D +     + CP GL      
Sbjct: 1018 GVCA--HGKC-TNLEGSFR---CSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEG 1071

Query: 971  GFASRDFLSGRPFYKDVNECK-----VFPGLCTHGTCRNTVGSFHCA-CAGGFALDAQER 1024
             FA     +G    +D   C+      FPG+C  G C NT GSF C  C GG+       
Sbjct: 1072 SFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGD 1131

Query: 1025 NCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKN--CMDVDECARDPLLC 1082
            +C D+DEC      C  G C NT GS++C C      GF L     C DV+EC  +    
Sbjct: 1132 SCEDVDECEDPQSSCLGGECKNTVGSYQCLC----PQGFQLANGTVCEDVNECMGEEHCA 1187

Query: 1083 RGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHA 1142
              G C N+ GS+ C C PG      GT+C+D+DEC+ +D  C  G CVN  G+F C C  
Sbjct: 1188 PHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFNCLCET 1246

Query: 1143 GFQSTPDRQGCVDINECRVQNGGCDV----HCINTEGSYRC--SCGQGYSLMPDGRACAD 1196
            GFQ +P+   CVDI+EC  ++ G  V     C N+ GSYRC   C  G+ + P+G  C D
Sbjct: 1247 GFQPSPESGECVDIDEC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCID 1303

Query: 1197 VDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCEN 1256
            +DEC  +      G C N  G  RCLC  GF  +P    CVDV+EC+L   +C    CEN
Sbjct: 1304 IDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCEN 1363

Query: 1257 TKGSFVCHC---------QLGYMVRKGATGCSDVDECEVGGH-------NCDS----HAS 1296
             +GSF+C C         Q G+   +GA G S + E   G H       +C S    HA 
Sbjct: 1364 VEGSFLCLCASDLEEYDAQEGHCRPRGAGGQS-MSEAPTGDHAPAPTRMDCYSGQKGHAP 1422

Query: 1297 CLNIPG----SFSCRCLPG----------------------------------WVGDGFE 1318
            C ++ G       C C  G                                  W      
Sbjct: 1423 CSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTM 1482

Query: 1319 CHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFF--CEDRDECAENVDLCDNG 1376
              D DECV       P G CLN    Y C C  GF  D     CED DEC +    C+NG
Sbjct: 1483 YTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENG 1540

Query: 1377 QCLNAPGGYRCEC 1389
            +C+N  G + C C
Sbjct: 1541 ECVNTEGSFHCFC 1553



 Score =  397 bits (1021), Expect = e-110
 Identities = 319/1081 (29%), Positives = 437/1081 (40%), Gaps = 206/1081 (19%)

Query: 479  QATPTRQACVD-----VDECIVSG-GLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDH 532
            Q TP+    V      +D C      +C  G CVN    ++CVC+ G++L P    C D 
Sbjct: 829  QVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDD 888

Query: 533  NECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGG--HYCMDIDECQTPGICVNGHCTNT 590
            NEC        G C+N  GS+SC C PG+ LA  G    C DI+EC+ PG+C  G CTNT
Sbjct: 889  NECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNT 948

Query: 591  EGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHG 650
            EGS+ C+C  G  +   G  C D +      G    G C    PG+ T   C     + G
Sbjct: 949  EGSYHCECDQGYIMVRKGH-CQDIN-ECRHPGTCPDGRCVNS-PGSYTCLAC-----EEG 1000

Query: 651  FGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCN 710
            +      C                       D+NEC L P VCA+G C NL GS+RC C 
Sbjct: 1001 YRGQSGSCV----------------------DVNEC-LTPGVCAHGKCTNLEGSFRCSCE 1037

Query: 711  LGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCS-CPPGFHFWQDTEICKDVDE 769
             GYE  +  K C DVDECA  +  C  G C N+ GS++CS C  G+   +D   C+D+DE
Sbjct: 1038 QGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDE 1096

Query: 770  C-LSSPCVSGVCRNLAGSYTCK-CGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQG 827
            C     C SGVC N AGS++CK C  G R  P G  C D  +           CE + Q 
Sbjct: 1097 CAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDE-----------CE-DPQS 1144

Query: 828  ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVN 887
            + L  EC  T+G+       +C     C +GF    G  C+DVNEC       P+G C+N
Sbjct: 1145 SCLGGECKNTVGSY------QC----LCPQGFQLANGTVCEDVNECMGEEHCAPHGECLN 1194

Query: 888  TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLP--GKYRMDV-----CC 940
            + GSF C C  G +    G  C DV           DEC  T P  G + ++      C 
Sbjct: 1195 SHGSFFCLCAPGFVSAEGGTSCQDV-----------DECATTDPCVGGHCVNTEGSFNCL 1243

Query: 941  CSIGAVWGVECEACPDPESLEFAS-------LCPRGLGFASRDFLSGRPFYK-------- 985
            C  G     E   C D +  E           C    G + R  L  +P +         
Sbjct: 1244 CETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPG-SYRCVLGCQPGFHMAPNGDCI 1302

Query: 986  DVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCV 1045
            D++EC       +HG C NT GSF C C  GF +     +C D++EC +   +CG   C 
Sbjct: 1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCE 1362

Query: 1046 NTPGSFECECFPGYE-------------SGFMLMKNCMDVDEC-ARDPLLCRGGT----- 1086
            N  GSF C C    E             +G   M      D   A   + C  G      
Sbjct: 1363 NVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAP 1422

Query: 1087 CTNTDG----SYKCQCPPGHELTAKGTACE------------------------------ 1112
            C++  G      +C C  G    + G AC+                              
Sbjct: 1423 CSSVLGRNTTQAECCCTQG---ASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFG 1479

Query: 1113 -----DIDECSL-SDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECR---VQN 1163
                 D DEC +   GLCP+G+C+N +  + C C+ GF      + C D +EC+    +N
Sbjct: 1480 QTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACEN 1539

Query: 1164 GGCDVHCINTEGSYRCSCGQGYSLMPDGRACA-------DVDECEENPRVC----DQGHC 1212
            G     C+NTEGS+ C C    +L    + C        D+ + + +  +C        C
Sbjct: 1540 G----ECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVC 1595

Query: 1213 TNMPGGHR-----CLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQL 1267
            +    GHR     C C DG   +     C      ++   +C     E  + + V H + 
Sbjct: 1596 SEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSS-EVYAQLCNVARIEAEREAGV-HFRP 1653

Query: 1268 GYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVS 1327
            GY    G     D     + G +     + L    +      P   G   +   + E   
Sbjct: 1654 GYEYGPGP----DDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPL 1709

Query: 1328 QEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRC 1387
            Q     P          Y  +  +  AG  F     +EC   ++ C+NG+C+    GY C
Sbjct: 1710 QPSELQPH---------YVASHPEPPAG--FEGLQAEECGI-LNGCENGRCVRVREGYTC 1757

Query: 1388 ECEMGFDPTEDHRACQDVDECAQGN----LCAFGSCENLPGMFRCICNGGYELDRGGGNC 1443
            +C  GF     H AC DV+EC   N    LC  G CEN  G +RC C+ GY  + G  +C
Sbjct: 1758 DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817

Query: 1444 T 1444
            T
Sbjct: 1818 T 1818



 Score =  378 bits (970), Expect = e-104
 Identities = 313/1079 (29%), Positives = 429/1079 (39%), Gaps = 186/1079 (17%)

Query: 1446 INECADPVN--CINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSG 1503
            I+ CA      C  G C+N P  Y C C   ++L+PS   C D     C  +        
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDN--ECLRDP------- 895

Query: 1504 ISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILED 1563
                            C   GR          +     Y   C  G     +  T   +D
Sbjct: 896  ----------------CKGKGRC---------INRVGSYSCFCYPGYTLATSGATQECQD 930

Query: 1564 IDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYN 1623
            I+EC++ PG+C GG C NT GS+ CEC  GY +      C+DI+EC  H G C  G C N
Sbjct: 931  INECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGH-CQDINECR-HPGTCPDGRCVN 987

Query: 1624 TLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQA 1683
            + G+YTC+   E  +   G+ C+D+ + +      G C +    N+     C        
Sbjct: 988  SPGSYTCLACEEGYRGQSGS-CVDVNECLT----PGVCAHGKCTNLEGSFRCS------- 1035

Query: 1684 WNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGS 1743
                CE         Y++    +              D+DEC    A C  G+C+N  GS
Sbjct: 1036 ----CEQ-------GYEVTSDEKGCQ-----------DVDECAS-RASCPTGLCLNTEGS 1072

Query: 1744 FRCE-CPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCK-CTRGYKLSP-G 1800
            F C  C  G+  N    ACED+DEC      C     C N  GS+ CK C  GY+ SP G
Sbjct: 1073 FACSACENGYWVNEDGTACEDLDECAF-PGVCPSGV-CTNTAGSFSCKDCDGGYRPSPLG 1130

Query: 1801 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC--DRQPCGN 1858
             +C   +EC +  + C  G+C +T GSY CLC +GFQ  A+ T+C D++EC  +     +
Sbjct: 1131 DSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPH 1189

Query: 1859 GTCKNIIGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDG 1917
            G C N  GS+ CLC PGFV    G  C D DEC T     C  GHC+NT GSF+CLC+ G
Sbjct: 1190 GECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATT--DPCVGGHCVNTEGSFNCLCETG 1247

Query: 1918 FELTADGKNCVDTNECLSLAG-TCLPGTCQNLEGSFRCI--CPPGFQVQSD-HCIDIDEC 1973
            F+ + +   CVD +EC       C    C+N  GS+RC+  C PGF +  +  CIDIDEC
Sbjct: 1248 FQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDEC 1307

Query: 1974 SEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFN 2033
            + +      G C N+ GSF+CLC  GF +S +G  C D  +           C      N
Sbjct: 1308 ANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNEC----ELMLAVCGAALCEN 1363

Query: 2034 TTKT-RCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENP 2092
               +  C C+    E         P+          P G  A   P  +R D     +  
Sbjct: 1364 VEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHA---PAPTRMDCYSGQKGH 1420

Query: 2093 GVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECAC 2152
              C++ +  NT  +  C C  G S       C   D       C  G     + G     
Sbjct: 1421 APCSSVLGRNTTQA-ECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEG----- 1474

Query: 2153 ADGFEPGLMMTCEDIDECSL-NPLLCAF-RCHNTEGSYLCTCPAGYTLREDGAMCRDVDE 2210
               +  G  M   D DEC +  P LC   RC NT   Y+C C  G+        C D DE
Sbjct: 1475 --AWTFGQTMYT-DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDE 1531

Query: 2211 CADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTD---------DNECHAQPD 2261
            C    QD      EC N  G+F C C P +  L  S + C +         D++ H   D
Sbjct: 1532 C----QDLACENGECVNTEGSFHCFCSPPLT-LDLSQQRCMNSTSSTEDLPDHDIHM--D 1584

Query: 2262 LC----VNGRCVNTAGSFR-----CDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSL 2312
            +C     N  C       R     C C +G   S     C      P  +EV   +C   
Sbjct: 1585 ICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCP-----PRSSEVYAQLCNVA 1639

Query: 2313 SSSSEAVTRAECCCGGGRGWGP---RCELCPLPGTSAYRKL----------CPHGSGYTA 2359
               +E         G   G GP      +    G   Y  L           P+ +G++A
Sbjct: 1640 RIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSA 1699

Query: 2360 ------------------------------EGRDVDECRMLAHLCAHGECINSLGSFRCH 2389
                                          EG   +EC +L + C +G C+     + C 
Sbjct: 1700 DRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGIL-NGCENGRCVRVREGYTCD 1758

Query: 2390 CQAGYTPDATATTCLDMDECSQVPKPCTF----LCKNTKGSFLCSCPRGYLLEEDGRTC 2444
            C  G+  DA    C+D++EC  +  P        C+NT+GS+ C C  GY+ E     C
Sbjct: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817



 Score =  372 bits (955), Expect = e-102
 Identities = 395/1388 (28%), Positives = 510/1388 (36%), Gaps = 326/1388 (23%)

Query: 1375 NGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGY 1434
            NGQC N             + T     C  V       LCA   C   P     I NG  
Sbjct: 560  NGQCANPL----------LELTTQEDCCGSVGAFWGVTLCA--PCPPRPAS-PVIENGQL 606

Query: 1435 ELDRGGG-----NCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
            E  +G       +C DINEC     C +  C+NT GSYLC+C     L+PS   CV  +A
Sbjct: 607  ECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKA 666

Query: 1490 --------------GNCFLETHDRGDSGISCSAEI------------------------- 1510
                          G C L    R    I C + +                         
Sbjct: 667  ISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPA 726

Query: 1511 GVGVTRASCCCSLGRAWGNPCELC--PMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ 1568
            G G T AS    L        EL   P           PG    QP R  V+ +   E  
Sbjct: 727  GHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLR--VVTDTWLEAG 784

Query: 1569 ELP--GLCQGGDCVNTF--------GSFQCECPPGYHLSEH-------------TRICED 1605
             +P  G  Q G    +         G+      P   ++E              T     
Sbjct: 785  TIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPG 844

Query: 1606 IDECSTHS-GICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNE 1664
            ID C+  +  +CGPGTC N    Y CVC   Y        C D               NE
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTD--------------DNE 890

Query: 1665 LAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFL--TDIHTGKPLDI 1722
               +  +    C   +G                 Y   C    PG+   T   T +  DI
Sbjct: 891  CLRDPCKGKGRCINRVGS----------------YSCFC---YPGYTLATSGATQECQDI 931

Query: 1723 DECGEIPAICANGICINQIGSFRCECPAGFNYNSILLA---CEDVDECGSRESPCQQNAD 1779
            +EC E P +C+ G C N  GS+ CEC  G+    I++    C+D++EC  R      +  
Sbjct: 932  NEC-EQPGVCSGGQCTNTEGSYHCECDQGY----IMVRKGHCQDINEC--RHPGTCPDGR 984

Query: 1780 CINIPGSYRC-KCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA 1838
            C+N PGSY C  C  GY+    G+CV  NEC   P VC+HG C + EGS+ C C +G++ 
Sbjct: 985  CVNSPGSYTCLACEEGYR-GQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEV 1042

Query: 1839 SADQTLCMDIDEC-DRQPCGNGTCKNIIGSYNC-LCFPGFVVTHNGD-CVDFDECTTLVG 1895
            ++D+  C D+DEC  R  C  G C N  GS+ C  C  G+ V  +G  C D DEC     
Sbjct: 1043 TSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECA--FP 1100

Query: 1896 QVCRFGHCLNTAGSFHCL-CQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRC 1954
             VC  G C NTAGSF C  C  G+  +  G +C D +EC     +CL G C+N  GS++C
Sbjct: 1101 GVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQC 1160

Query: 1955 ICPPGFQVQSDH-CIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFD-- 2011
            +CP GFQ+ +   C D++EC  E +    G C NS GSF CLC PGFV ++ G  C D  
Sbjct: 1161 LCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVD 1220

Query: 2012 ---------------TRQSF---CFTRF----EAGKC--------------SVPKAFNTT 2035
                           T  SF   C T F    E+G+C                 K  N+ 
Sbjct: 1221 ECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSP 1280

Query: 2036 KT-RCCCSKRPGEGWG--------DPCE---LCPQEG-----SAAFQELCPFGHGAVPGP 2078
             + RC    +PG            D C    +C   G       +F+ LC  G    P  
Sbjct: 1281 GSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSG 1340

Query: 2079 DDSREDVNECAENPGVCTNGVCVNTDGSFRCECPF------------------GYSLDF- 2119
             D   DVNEC     VC   +C N +GSF C C                    G S+   
Sbjct: 1341 WDC-VDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEA 1399

Query: 2120 -TGINCVDTD--ECSVGHPCGQGTCTNVIGG----FECACADGFEPGLMMTCEDIDECSL 2172
             TG +       +C  G   G   C++V+G      EC C  G   G        D C L
Sbjct: 1400 PTGDHAPAPTRMDCYSGQK-GHAPCSSVLGRNTTQAECCCTQGASWG--------DACDL 1450

Query: 2173 NPLLCAFRCHNTEGSYLCTCPAGYTLREDG-----AMCRDVDECADGQQDCHARGMECKN 2227
             P        + E S +C    GY   E        M  D DEC          G  C N
Sbjct: 1451 CPSE-----DSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLN 1504

Query: 2228 LIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSP 2287
             +  + C+C PG      S + C D +EC  Q   C NG CVNT GSF C C        
Sbjct: 1505 TVPGYVCLCNPGFH-YDASHKKCEDHDEC--QDLACENGECVNTEGSFHCFCSPPLTLDL 1561

Query: 2288 TLTEC------------HDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR 2335
            +   C            HDI    C+ +V   +C S        T  ECCC  G  W  +
Sbjct: 1562 SQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVC-SEPLRGHRTTYTECCCQDGEAWSQQ 1620

Query: 2336 CELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLC--AHGECINSLG-SFRCHCQA 2392
            C             LCP  S             + A LC  A  E     G  FR   + 
Sbjct: 1621 CA------------LCPPRSS-----------EVYAQLCNVARIEAEREAGVHFRPGYEY 1657

Query: 2393 GYTPDATATTCLDMDEC---------SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRT 2443
            G  PD    +    D             VP+P      NT G    S  R  +LE   + 
Sbjct: 1658 GPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAF---PNTAGH---SADRTPILESPLQP 1711

Query: 2444 CKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCH 2503
             +      +                    PP   +  QA    +EC    G C  +G C 
Sbjct: 1712 SELQPHYVASHPE----------------PPAGFEGLQA----EECGILNG-C-ENGRCV 1749

Query: 2504 NTPGSFRCECHQGFTLVSSGHGCEDVNECD---GPH-RCQHG-CQNQLGGYRCSCPQGFT 2558
                 + C+C +GF L ++   C DVNECD   GP   C HG C+N  G YRC C  G+ 
Sbjct: 1750 RVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYV 1809

Query: 2559 QHSQWAQC 2566
              +    C
Sbjct: 1810 AEAGPPHC 1817



 Score =  327 bits (839), Expect = 8e-89
 Identities = 238/706 (33%), Positives = 311/706 (44%), Gaps = 144/706 (20%)

Query: 1970 IDECSE-EPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
            ID C+    N+C  GTC N P  ++C+C PG+ L  +   C D  +              
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNE-------------- 890

Query: 2029 PKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG-AVPGPDDSREDVNE 2087
                        C + P +G G       + GS  +   C  G+  A  G     +D+NE
Sbjct: 891  ------------CLRDPCKGKG---RCINRVGS--YSCFCYPGYTLATSGATQECQDINE 933

Query: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGG 2147
            C E PGVC+ G C NT+GS+ CEC  GY +   G +C D +EC     C  G C N  G 
Sbjct: 934  C-EQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGS 991

Query: 2148 FEC-ACADGFEPGLMMTCEDIDECSLNPLLCAF-RCHNTEGSYLCTCPAGYTLREDGAMC 2205
            + C AC +G+  G   +C D++EC L P +CA  +C N EGS+ C+C  GY +  D   C
Sbjct: 992  YTCLACEEGYR-GQSGSCVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGC 1049

Query: 2206 RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVN 2265
            +DVDECA  +  C   G+ C N  G+FAC        +   G  C D +EC A P +C +
Sbjct: 1050 QDVDECAS-RASCPT-GL-CLNTEGSFACSACENGYWVNEDGTACEDLDEC-AFPGVCPS 1105

Query: 2266 GRCVNTAGSFRC-DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAEC 2324
            G C NTAGSF C DCD G++PSP    C D+ +           C    SS         
Sbjct: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDE-----------CEDPQSS--------- 1145

Query: 2325 CCGGGRGWGPRCELCPLPGTSAYRKLCPHG----SGYTAEGRDVDECRMLAHLCAHGECI 2380
            C GG       C+        +Y+ LCP G    +G   E  DV+EC    H   HGEC+
Sbjct: 1146 CLGG------ECKNT----VGSYQCLCPQGFQLANGTVCE--DVNECMGEEHCAPHGECL 1193

Query: 2381 NSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEED 2440
            NS GSF C C  G+      T+C D+DEC+         C NT+GSF C C  G+    +
Sbjct: 1194 NSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPE 1253

Query: 2441 GRTCKDLDECTSRQHNC--QFLCVNTVGAFTC--RCPPGFTQHHQA----CFDNDECSAQ 2492
               C D+DEC          + C N+ G++ C   C PGF   H A    C D DEC A 
Sbjct: 1254 SGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF---HMAPNGDCIDIDEC-AN 1309

Query: 2493 PGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCS 2552
               CG+HG C NT GSFRC C QGF +  SG  C DVNEC+                   
Sbjct: 1310 DTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECE------------------- 1350

Query: 2553 CPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGF-DFDQALGGCQEV 2611
                                 L    CG+A C N  G F C+C S   ++D   G C+  
Sbjct: 1351 ---------------------LMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRP- 1388

Query: 2612 DECAGRRGPCSYSCANTPGGFLCGCP--QGYFRAGQGH--CVSGLG 2653
                  RG    S +  P G     P     +   +GH  C S LG
Sbjct: 1389 ------RGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLG 1428



 Score =  247 bits (630), Expect = 1e-64
 Identities = 244/884 (27%), Positives = 334/884 (37%), Gaps = 220/884 (24%)

Query: 113  GVSRGSGCSVSCMNGGTC----RGASCLCQKGYTGTVCGQPIC--DRGCHNGGRCIGPNR 166
            G+ R +  + +    GTC     G  C+C  GY      Q  C  D  C     C G  R
Sbjct: 844  GIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQ-LHPSQAYCTDDNECLRDP-CKGKGR 901

Query: 167  CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
            C    G     C   Y           +         VC+   C  T G      CE   
Sbjct: 902  CINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEG---SYHCE--- 955

Query: 227  AQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHC-RCPVGHRLSDSSA 285
                 C +G+I  +  G CQD++EC+  PG C  G CVN  GS+ C  C  G+R    S 
Sbjct: 956  -----CDQGYIM-VRKGHCQDINECRH-PGTCPDGRCVNSPGSYTCLACEEGYR--GQSG 1006

Query: 286  ACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQL 345
            +C D        V   G+C  +L G +   +C C++G              +G  +  + 
Sbjct: 1007 SCVDVNECLTPGVCAHGKCT-NLEGSF---RCSCEQG-------YEVTSDEKGCQDVDE- 1054

Query: 346  CAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATL 405
            CA R     G                        LN  GS A      G   +  GTA  
Sbjct: 1055 CASRASCPTG----------------------LCLNTEGSFACSACENGYWVNEDGTAC- 1091

Query: 406  NQTIDICRHFTNLCLNGRCLPTPSSYRC-ECNVGYTQDVRGE-CIDVDECTS--SPCHHG 461
             + +D C  F  +C +G C  T  S+ C +C+ GY     G+ C DVDEC    S C  G
Sbjct: 1092 -EDLDECA-FPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGG 1149

Query: 462  DCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFE 521
            +C N  G+Y C C  GFQ       C DV+EC+        G C+N+ GSF C+C  GF 
Sbjct: 1150 ECKNTVGSYQCLCPQGFQLA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFV 1208

Query: 522  LSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPG- 580
             +  G +C D +ECAT+  CV G C+N +GSF+CLC+ GF  +P    C+DIDEC+  G 
Sbjct: 1209 SAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGD 1268

Query: 581  -ICVNGHCTNTEGSFRC--QCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTV 637
             +C    C N+ GS+RC   C  G  +  +G  C+D               CA       
Sbjct: 1269 PVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDI------------DECA------- 1308

Query: 638  TKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDPEVCA 694
              ++  C +  HGF      C   D + F+ LC  G  I+  G    D+NEC L   VC 
Sbjct: 1309 --NDTMCGS--HGF------CDNTDGS-FRCLCDQGFEISPSGWDCVDVNECELMLAVCG 1357

Query: 695  NGVCENLRGSYRCVCNLGYE-----------AGASGKDCTDV----DECALNSLLCDNGW 739
              +CEN+ GS+ C+C    E            GA G+  ++        A   + C +G 
Sbjct: 1358 AALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ 1417

Query: 740  CQNSPGS---------YSCSCPPGFHFWQD-------------TEIC------------- 764
              ++P S           C C  G   W D             +EIC             
Sbjct: 1418 KGHAPCSSVLGRNTTQAECCCTQGAS-WGDACDLCPSEDSAEFSEICPSGKGYIPVEGAW 1476

Query: 765  -------KDVDECL---SSPCVSGVCRNLAGSYTCKCGPGSRLDPS-------------- 800
                    D DEC+      C +G C N    Y C C PG   D S              
Sbjct: 1477 TFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA 1536

Query: 801  ----------GTF----------------CLDSTKGT------------CWLKIQESRCE 822
                      G+F                C++ST  T            CW K+    C 
Sbjct: 1537 CENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCS 1596

Query: 823  VNLQG-ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGV 865
              L+G  +  +ECC   G AW   C  C   P  +  +A++  V
Sbjct: 1597 EPLRGHRTTYTECCCQDGEAWSQQCALC--PPRSSEVYAQLCNV 1638



 Score =  171 bits (432), Expect = 1e-41
 Identities = 222/958 (23%), Positives = 317/958 (33%), Gaps = 286/958 (29%)

Query: 55   QGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLC-----TCADGTLA 109
            +G   C +R  +Y C     +PG +       +       C QP +C     T  +G+  
Sbjct: 897  KGKGRCINRVGSYSC---FCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYH 953

Query: 110  PSCG-----VSRGSGCSVS-CMNGGTCRGASCL----------CQKGYTGTVCGQPICDR 153
              C      V +G    ++ C + GTC    C+          C++GY G   G  +   
Sbjct: 954  CECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQ-SGSCVDVN 1012

Query: 154  GCHNGGRCI--------GPNRCACVYGFMGPQCERDYR------------TGPCFGQVGP 193
             C   G C         G  RC+C  G+     E+  +            TG C    G 
Sbjct: 1013 ECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGS 1072

Query: 194  EGCQHQLTGL-------------------VCTKALCCATVGRAWGLPCELCPAQPHPCRR 234
              C     G                    VC   +C  T G      C+ C         
Sbjct: 1073 FACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAG---SFSCKDCDG------- 1122

Query: 235  GFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGA 294
            G+ P+    +C+DVDEC+     C GG C N VGS+ C CP G +L++ +  CED     
Sbjct: 1123 GYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGT-VCEDV---- 1177

Query: 295  CFSVLFGGRCAGDLAGHYTRRQCCCDRGRCW-AAGPVPELCPP-----RGSNEFQQL--C 346
                     C G+        + C   G C  + G    LC P      G    Q +  C
Sbjct: 1178 -------NECMGE--------EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDEC 1222

Query: 347  AQRLPLLPGH----PGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGT 402
            A   P + GH     G F  L      G  P       +P   +                
Sbjct: 1223 ATTDPCVGGHCVNTEGSFNCLC---ETGFQP-------SPESGEC--------------- 1257

Query: 403  ATLNQTIDICRHFTN-LCLNGRCLPTPSSYRC--ECNVGYTQDVRGECIDVDECTSSPC- 458
                  ID C  + + +C   +C  +P SYRC   C  G+     G+CID+DEC +    
Sbjct: 1258 ----VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMC 1313

Query: 459  -HHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCN 517
              HG C N  G++ C C  GF+ +P+   CVDV+EC +   +C    C N EGSF C+C 
Sbjct: 1314 GSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCA 1373

Query: 518  AGFE--------LSPDGKN--------CVDHNECATSTMCVNG----------------- 544
            +  E          P G            DH    T   C +G                 
Sbjct: 1374 SDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQ 1433

Query: 545  ----------------VCLNEDGS-FSCLCKPGFLLAP-------GGHYCMDIDECQT-- 578
                            +C +ED + FS +C  G    P       G     D DEC    
Sbjct: 1434 AECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFG 1493

Query: 579  PGICVN----------------------------------------GHCTNTEGSFRCQC 598
            PG+C N                                        G C NTEGSF C C
Sbjct: 1494 PGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFC 1553

Query: 599  LGGLAVGTDGRVCV------------DTHVRSTCYGAIEKGSCARPFPG-TVTKSECCCA 645
               L +    + C+            D H+   C+  +    C+ P  G   T +ECCC 
Sbjct: 1554 SPPLTLDLSQQRCMNSTSSTEDLPDHDIHM-DICWKKVTNDVCSEPLRGHRTTYTECCCQ 1612

Query: 646  NPDHGFGEPCQLCPAKDSAEFQALCS---------------SGLGITTDGRDINECALDP 690
            + +  + + C LCP + S  +  LC+                G        D++     P
Sbjct: 1613 DGE-AWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGP 1671

Query: 691  EVCANGVCENLRGSYRCVCNLGY-EAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSC 749
            +        N  G    V    +        D T + E  L        +  + P     
Sbjct: 1672 D---GAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHP----- 1723

Query: 750  SCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLD 806
              P GF   Q        +EC + + C +G C  +   YTC C  G +LD +   C+D
Sbjct: 1724 EPPAGFEGLQ-------AEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVD 1774



 Score =  131 bits (330), Expect = 8e-30
 Identities = 155/590 (26%), Positives = 210/590 (35%), Gaps = 172/590 (29%)

Query: 69   CPGWR--TFPGRSQCVVPICRRACGEGFCSQPN-----LCTCADGTLAPSCGVSRGSGCS 121
            C  W+    PG  +CV+      C  GF   PN     +  CA+ T+  S G        
Sbjct: 1271 CGTWKCENSPGSYRCVL-----GCQPGFHMAPNGDCIDIDECANDTMCGSHGF------- 1318

Query: 122  VSCMNGGTCRGASCLCQKGYTGT-----------------VCGQPICDRG-------CHN 157
              C N  T     CLC +G+  +                 VCG  +C+         C +
Sbjct: 1319 --CDN--TDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374

Query: 158  GGRCIGPNRCACVYGFMGPQCERDYRTGP---------CF-GQVGPEGCQHQLTGLVCTK 207
                       C     G Q   +  TG          C+ GQ G   C   L G   T+
Sbjct: 1375 DLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVL-GRNTTQ 1433

Query: 208  ALCCATVGRAWGLPCELCPAQPH-------PCRRGFIP---------NIHTGA------- 244
            A CC T G +WG  C+LCP++         P  +G+IP          ++T A       
Sbjct: 1434 AECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFG 1493

Query: 245  --------------------------------CQDVDECQAVPGLCQGGSCVNMVGSFHC 272
                                            C+D DECQ +   C+ G CVN  GSFHC
Sbjct: 1494 PGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENGECVNTEGSFHC 1551

Query: 273  RCPVGHRLSDSSAAC------------EDYRAGACFSVLFGGRCAGDLAGHYTR-RQCCC 319
             C     L  S   C             D     C+  +    C+  L GH T   +CCC
Sbjct: 1552 FCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCC 1611

Query: 320  DRGRCWAAGPVPELCPPRGSNEFQQLC------AQR---LPLLPGHP-GLFPGLLGFGSN 369
              G  W+      LCPPR S  + QLC      A+R   +   PG+  G  P  L +   
Sbjct: 1612 QDGEAWSQQCA--LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIY 1669

Query: 370  GM-GPP----LGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRC 424
            G  G P    LGP    P  +     P+   G+S   T  L   +               
Sbjct: 1670 GPDGAPFYNYLGPEDTVPEPA----FPNTA-GHSADRTPILESPLQ-------------- 1710

Query: 425  LPTPSSYRCECNVGYTQDVRG-ECIDVDEC-TSSPCHHGDCVNIPGTYHCRCYPGFQATP 482
               PS  +      + +   G E +  +EC   + C +G CV +   Y C C+ GFQ   
Sbjct: 1711 ---PSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDA 1767

Query: 483  TRQACVDVDECIVSGG---LCHLGRCVNTEGSFQCVCNAGFELSPDGKNC 529
               ACVDV+EC    G   LC  G C NTEGS++C C+ G+       +C
Sbjct: 1768 AHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817



 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 49/161 (30%), Positives = 62/161 (38%), Gaps = 9/161 (5%)

Query: 350 LPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTI 409
           LP  PGH       +   S     PL PA   P G   R   +   G        L    
Sbjct: 515 LPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQE 574

Query: 410 DICRH---FTNLCLNGRCLPTPSSY-----RCECNVGYTQDVRGECIDVDEC-TSSPCHH 460
           D C     F  + L   C P P+S      + EC  GY +     C D++EC T   C  
Sbjct: 575 DCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKD 634

Query: 461 GDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCH 501
            +CVN  G+Y C C PG    P+R  CV      +  GLC+
Sbjct: 635 AECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCY 675



 Score = 58.9 bits (141), Expect = 7e-08
 Identities = 26/62 (41%), Positives = 31/62 (50%), Gaps = 5/62 (8%)

Query: 52  GILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRAC-GEGFCSQPNLCTCADGTLAP 110
           G L G NVCG +    CCPGW T    + C+ P+C   C   G CS+P LC C  G    
Sbjct: 161 GRLTGRNVCGGQ----CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGA 216

Query: 111 SC 112
            C
Sbjct: 217 RC 218



 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 16/185 (8%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR-CELCP----LPGTSAYRKLCP 2352
            G C+   +   C +     E  T+ +CC   G  WG   C  CP     P     +  CP
Sbjct: 552  GRCYLNTVNGQCAN--PLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECP 609

Query: 2353 HGSGYT--AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECS 2410
             G         +D++EC  L  LC   EC+N+ GS+ C C+ G   D + + C+     S
Sbjct: 610  QGYKRLNLTHCQDINECLTLG-LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAIS 668

Query: 2411 QVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTC 2470
             +      LC  + G   C+ P    + +    C  + +    +  C+   +    AF  
Sbjct: 669  MLQG----LCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFRE 722

Query: 2471 RCPPG 2475
             CP G
Sbjct: 723  ICPAG 727



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 6/83 (7%)

Query: 1249 CLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECE--VGGHNCDSHASCLNIPGSFSC 1306
            C +G C   +  + C C  G+ +      C DV+EC+   G      H  C N  GS+ C
Sbjct: 1743 CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRC 1802

Query: 1307 RCLPGWVGDGFECHDLDECVSQE 1329
             C PG+V +    H    C ++E
Sbjct: 1803 HCSPGYVAEAGPPH----CTAKE 1821



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 45/173 (26%), Positives = 62/173 (35%), Gaps = 11/173 (6%)

Query: 2491 AQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQ----HGCQNQL 2546
            A P P G  G C+    + +C  +    L +    C  V    G   C           +
Sbjct: 543  AAPRPRGLLGRCYLNTVNGQC-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVI 601

Query: 2547 GGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALG 2606
               +  CPQG+ +      C D NEC L+   C  A C NT G + C C  G   D +  
Sbjct: 602  ENGQLECPQGY-KRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRS 659

Query: 2607 GCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
             C      +  +G C  S    PG   C  P       Q  C S +G + G +
Sbjct: 660  RCVSDKAISMLQGLCYRSLG--PG--TCTLPLAQRITKQICCCSRVGKAWGSE 708



 Score = 42.0 bits (97), Expect = 0.009
 Identities = 35/132 (26%), Positives = 49/132 (37%), Gaps = 10/132 (7%)

Query: 110 PSCGVSRGSGCSVSCMNGGTCRGASCL---CQKGYTGTV----CGQPICDRGCHNGGRCI 162
           P  G  + SG +      G   G +     C  G+T       C +P+C+  C N G C 
Sbjct: 143 PRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCS 202

Query: 163 GPNRCACVYGFMGPQCER---DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWG 219
            P  C C  GF G +CE    D    P   ++ P     +   L  + A    T+ RA  
Sbjct: 203 RPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQP 262

Query: 220 LPCELCPAQPHP 231
              +  PA   P
Sbjct: 263 PAPQSPPAPQSP 274



 Score = 42.0 bits (97), Expect = 0.009
 Identities = 27/78 (34%), Positives = 32/78 (41%), Gaps = 17/78 (21%)

Query: 85  ICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSG-----------CSVSCMNGGTCRGA 133
           IC++ C  G C+  N C   D T   S G   G G           C + C+NGG C G 
Sbjct: 359 ICKQTCARGHCA--NSCERGDTTTLYSQG---GHGHDPKSGFRIYFCQIPCLNGGRCIGR 413

Query: 134 -SCLCQKGYTGTVCGQPI 150
             C C    TG  C  PI
Sbjct: 414 DECWCPANSTGKFCHLPI 431



 Score = 34.3 bits (77), Expect = 1.8
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 15/65 (23%)

Query: 129 TCRGASCL--CQKGYTGTVCGQP-------------ICDRGCHNGGRCIGPNRCACVYGF 173
           TC    C   C++G T T+  Q               C   C NGGRCIG + C C    
Sbjct: 363 TCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANS 422

Query: 174 MGPQC 178
            G  C
Sbjct: 423 TGKFC 427


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  494 bits (1271), Expect = e-139
 Identities = 482/1575 (30%), Positives = 649/1575 (41%), Gaps = 361/1575 (22%)

Query: 76   PGRSQCVVPICRRACGEGFCSQPNL----CTCADGTLAPSCGVSRGSGCSVS-CMNGGTC 130
            P  + C+   CR     G C    L    C C  G    SC   +   C+ + C NGG C
Sbjct: 101  PLDNACLTNPCRNG---GTCDLLTLTEYKCRCPPGWSGKSC--QQADPCASNPCANGGQC 155

Query: 131  ----RGASCLCQKGYTGTVCGQPICDRG-----CHNGGRC---IGPNRCACVYGFMGPQC 178
                    C C   + G  C Q + + G     C +GG C   +G  RC C     GP C
Sbjct: 156  LPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNC 215

Query: 179  ERDYRTGPCFGQVGPEGCQH----QLTGLVCTKALCCATVGRAWGLPCEL----CPAQPH 230
            ER Y   PC     P  CQ+    + TG V  +   CA +    G  CE     CP   +
Sbjct: 216  ERPYV--PC----SPSPCQNGGTCRPTGDVTHE---CACLPGFTGQNCEENIDDCPG--N 264

Query: 231  PCRRG--FIPNIHTGAC------------QDVDECQAVPGLCQ-GGSCVNMVGSFHCRCP 275
             C+ G   +  ++T  C            +DVDECQ +P  CQ GG+C N  G ++C C 
Sbjct: 265  NCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCV 324

Query: 276  VGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP 335
             G    D S   +D  + ACF    G  C   +A  Y    C C  GR      + + C 
Sbjct: 325  NGWTGEDCSENIDDCASAACF---HGATCHDRVASFY----CECPHGRTGLLCHLNDACI 377

Query: 336  PRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS--L 393
                NE                         GSN    P+       +G      PS   
Sbjct: 378  SNPCNE-------------------------GSNCDTNPV-------NGKAICTCPSGYT 405

Query: 394  GPGNSNIGTATLNQTIDICRHFTNLCLN-GRCLPTPSSYRCECNVGYTQDVRGECIDVDE 452
            GP  S        Q +D C    N C + G+C+ T  S+ C+C  GYT   R E IDV+E
Sbjct: 406  GPACS--------QDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT-GPRCE-IDVNE 455

Query: 453  CTSSPCHH-GDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGS 511
            C S+PC +   C++  G + C C PG++        V+ DEC  S    H GRC++    
Sbjct: 456  CVSNPCQNDATCLDQIGEFQCICMPGYEGVHCE---VNTDEC-ASSPCLHNGRCLDKINE 511

Query: 512  FQCVCNAGFELSPDGKNC-VDHNECATSTMCVNGV-CLNEDGSFSCLCKPGFLLAPGGHY 569
            FQC C  GF     G  C  D +ECA ST C NG  CL+   +++C+C  G+    G H 
Sbjct: 512  FQCECPTGF----TGHLCQYDVDECA-STPCKNGAKCLDGPNTYTCVCTEGY---TGTHC 563

Query: 570  CMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSC 629
             +DIDEC  P  C  G C +   +F C C  G      G  C +T++             
Sbjct: 564  EVDIDECD-PDPCHYGSCKDGVATFTCLCRPGYT----GHHC-ETNI------------- 604

Query: 630  ARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDIN--ECA 687
                      +EC      HG       C  +D+A    LC    G T    +IN  +CA
Sbjct: 605  ----------NECSSQPCRHG-----GTCQDRDNA---YLCFCLKGTTGPNCEINLDDCA 646

Query: 688  LDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCT-DVDECALNSLLCDN-GWCQNSPG 745
              P  C +G C +    Y C C  GY    +G  C  ++DECA N   C N G C++   
Sbjct: 647  SSP--CDSGTCLDKIDGYECACEPGY----TGSMCNINIDECAGNP--CHNGGTCEDGIN 698

Query: 746  SYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCL 805
             ++C CP G+H   D     +V+EC S+PCV G CR+    Y C C PG     SGT C 
Sbjct: 699  GFTCRCPEGYH---DPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGW----SGTNC- 750

Query: 806  DSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGV 865
                      I  + CE N     +    C  + +  G  C        C  GF   +G 
Sbjct: 751  ---------DINNNECESN---PCVNGGTCKDMTS--GYVC-------TCREGF---SGP 786

Query: 866  TCD-DVNECESFPGVCPN-GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDE 923
             C  ++NEC S P  C N G C++    ++C C    +L  +G  C +V L PC      
Sbjct: 787  NCQTNINECASNP--CLNQGTCIDDVAGYKCNC----LLPYTGATC-EVVLAPC------ 833

Query: 924  DECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPF 983
                   P   R            G EC    D ES  F+ +CP G          G+  
Sbjct: 834  ------APSPCRN-----------GGECRQSEDYES--FSCVCPTG--------WQGQTC 866

Query: 984  YKDVNECKVFPGLCTHG-TCRNTVGSFHCACAGGFALDAQERNC-TDIDECRISPDLCGQ 1041
              D+NEC + P  C HG +C+NT G + C C  G++     RNC TDID+CR +P   G 
Sbjct: 867  EVDINECVLSP--CRHGASCQNTHGGYRCHCQAGYS----GRNCETDIDDCRPNPCHNG- 919

Query: 1042 GTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCR-GGTCTNTDGSYKCQCPP 1100
            G+C +   +  C+C PG+   F       D++ECA DP  CR G  CT+   SY C CP 
Sbjct: 920  GSCTDGINTAFCDCLPGFRGTFCE----EDINECASDP--CRNGANCTDCVDSYTCTCPA 973

Query: 1101 GHELTAKGTACE----DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDI 1156
            G      G  CE    D  E S  +G    G CV+ I +F C C  GF  +  +    D+
Sbjct: 974  GF----SGIHCENNTPDCTESSCFNG----GTCVDGINSFTCLCPPGFTGSYCQH---DV 1022

Query: 1157 NECRVQ----NGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD-VDECEENPRVCDQGH 1211
            NEC  Q     G C   C    GSYRC+C QGY+    G  C + V  C+ +P   + G 
Sbjct: 1023 NECDSQPCLHGGTCQDGC----GSYRCTCPQGYT----GPNCQNLVHWCDSSP-CKNGGK 1073

Query: 1212 CTNMPGGHRCLCYDG----FMATPDMRTCVDVDECDLN-PHICLHGD-CENTKGSFVCHC 1265
            C      +RC C  G    +   P +   V      ++   +C HG  C +   +  C C
Sbjct: 1074 CWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRC 1133

Query: 1266 QLGYMVRKGATGCSD-VDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC-HDLD 1323
            Q GY      + C D VDEC      C + A+C +  G +SC+C+ G+   G  C  ++D
Sbjct: 1134 QAGYT----GSYCEDLVDECSPS--PCQNGATCTDYLGGYSCKCVAGY--HGVNCSEEID 1185

Query: 1324 ECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAENVD-------LCDN 1375
            EC+S  H C   G CL++P +Y+C+C +G    G  CE + D+C   VD         +N
Sbjct: 1186 ECLS--HPCQNGGTCLDLPNTYKCSCPRG--TQGVHCEINVDDCNPPVDPVSRSPKCFNN 1241

Query: 1376 GQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG--SCENLPGMFRCICNGG 1433
            G C++  GGY C C  GF      R   DV+EC      A G  +C      F C C  G
Sbjct: 1242 GTCVDQVGGYSCTCPPGF---VGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAG 1298

Query: 1434 YELDRGGGNCTDINECADPVNCING----VCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
            +     G  C  +        C NG    V  NT   ++C CP  FE    G  C +  A
Sbjct: 1299 HT----GRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFE----GATC-ENDA 1349

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCC-------------SLGRAWGNPC---EL 1533
              C       G + IS       G    +C C             S     GNPC     
Sbjct: 1350 RTCGSLRCLNGGTCIS-------GPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGT 1402

Query: 1534 C-PMANTTEYRTLCP 1547
            C P + +  YR LCP
Sbjct: 1403 CEPTSESPFYRCLCP 1417



 Score =  461 bits (1185), Expect = e-129
 Identities = 489/1787 (27%), Positives = 666/1787 (37%), Gaps = 416/1787 (23%)

Query: 948  GVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTH-GTC---- 1002
            G +CEA    E+      C  G  F         P  +D N C   P  C + GTC    
Sbjct: 34   GGKCEAANGTEA------CVCGGAFVG-------PRCQDPNPCLSTP--CKNAGTCHVVD 78

Query: 1003 RNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTC-VNTPGSFECECFPGYES 1061
            R  V  + C+CA GF+        T +D   ++      GTC + T   ++C C PG+  
Sbjct: 79   RRGVADYACSCALGFS---GPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSG 135

Query: 1062 GFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC-EDIDECSLS 1120
                 K+C   D CA +P    GG C   + SY C CPP       G  C +D++EC   
Sbjct: 136  -----KSCQQADPCASNPC-ANGGQCLPFEASYICHCPPSFH----GPTCRQDVNECGQK 185

Query: 1121 DGLCPHG-QCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG-------------- 1165
             GLC HG  C N +G+++C C A        +  V  +    QNGG              
Sbjct: 186  PGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECAC 245

Query: 1166 --------CDVH--------------CINTEGSYRCSCGQGYSLMPDGRACA-DVDECEE 1202
                    C+ +              C++   +Y C C   ++    G+ C  DVDEC+ 
Sbjct: 246  LPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWT----GQYCTEDVDECQL 301

Query: 1203 NPRVCDQGH-CTNMPGGHRCLCYDG-------------------------------FMAT 1230
             P  C  G  C N  GG+ C+C +G                               +   
Sbjct: 302  MPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCEC 361

Query: 1231 PDMRT---CVDVDECDLNPHICLHG---DCENTKGSFVCHCQLGYMVRKGATGCSDVDEC 1284
            P  RT   C   D C  NP  C  G   D     G  +C C  GY    G     DVDEC
Sbjct: 362  PHGRTGLLCHLNDACISNP--CNEGSNCDTNPVNGKAICTCPSGYT---GPACSQDVDEC 416

Query: 1285 EVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGS 1344
             +G + C+    C+N  GSF C+CL G+ G   E  D++ECVS  + C     CL+  G 
Sbjct: 417  SLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEI-DVNECVS--NPCQNDATCLDQIGE 473

Query: 1345 YRCTCRQGFAGDGFFCE-DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ 1403
            ++C C  G+  +G  CE + DECA +  L  NG+CL+    ++CEC  GF     H    
Sbjct: 474  FQCICMPGY--EGVHCEVNTDECASSPCL-HNGRCLDKINEFQCECPTGF---TGHLCQY 527

Query: 1404 DVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-TDINECADPVNCINGVCIN 1462
            DVDECA         C + P  + C+C  GY     G +C  DI+EC DP  C  G C +
Sbjct: 528  DVDECASTPCKNGAKCLDGPNTYTCVCTEGYT----GTHCEVDIDEC-DPDPCHYGSCKD 582

Query: 1463 TPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG------DSGISCSAEIGVGVTR 1516
               ++ C C   +    +G  C +T    C  +    G      D+   C      G T 
Sbjct: 583  GVATFTCLCRPGY----TGHHC-ETNINECSSQPCRHGGTCQDRDNAYLCFCL--KGTTG 635

Query: 1517 ASCCCSLGRAWGNPCELCPMANTTE-YRTLC-PGGEGFQPNRITVILEDIDECQELPGLC 1574
             +C  +L     +PC+     +  + Y   C PG  G   N       +IDEC   P   
Sbjct: 636  PNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCN------INIDECAGNP-CH 688

Query: 1575 QGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPA 1634
             GG C +    F C CP GYH         +++EC  +S  C  G C ++L  Y C C  
Sbjct: 689  NGGTCEDGINGFTCRCPEGYH---DPTCLSEVNEC--NSNPCVHGACRDSLNGYKCDCDP 743

Query: 1635 EYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCC----------CSYNIGQAW 1684
             +   N   N  +   + C     GTC+     ++T    C          C  NI +  
Sbjct: 744  GWSGTNCDINNNECESNPCVN--GGTCK-----DMTSGYVCTCREGFSGPNCQTNINECA 796

Query: 1685 NRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ---I 1741
            + PC    T I       C    P      +TG   ++      P+ C NG    Q    
Sbjct: 797  SNPCLNQGTCIDDVAGYKCNCLLP------YTGATCEVVLAPCAPSPCRNGGECRQSEDY 850

Query: 1742 GSFRCECPAGFNYNSILLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG 1800
             SF C CP G+   +    CE D++EC    SPC+  A C N  G YRC C  GY    G
Sbjct: 851  ESFSCVCPTGWQGQT----CEVDINECVL--SPCRHGASCQNTHGGYRCHCQAGYS---G 901

Query: 1801 GAC-VGRNECREIPNVCSH-GDCMDTEGSYMCLCHRGFQASADQTLC-MDIDECDRQPCG 1857
              C    ++CR  PN C + G C D   +  C C  GF+     T C  DI+EC   PC 
Sbjct: 902  RNCETDIDDCR--PNPCHNGGSCTDGINTAFCDCLPGFRG----TFCEEDINECASDPCR 955

Query: 1858 NG-TCKNIIGSYNCLCFPGFVVTH-NGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQ 1915
            NG  C + + SY C C  GF   H   +  D  E +   G     G C++   SF CLC 
Sbjct: 956  NGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNG-----GTCVDGINSFTCLCP 1010

Query: 1916 DGFELTADGKNCV-DTNECLSLAGTCL-PGTCQNLEGSFRCICPPGFQVQSDHCIDIDEC 1973
             GF     G  C  D NEC S    CL  GTCQ+  GS+RC CP G+     +C ++   
Sbjct: 1011 PGF----TGSYCQHDVNECDS--QPCLHGGTCQDGCGSYRCTCPQGY--TGPNCQNLVHW 1062

Query: 1974 SEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFN 2033
             +       G C  +   ++C CP G+                         C VP    
Sbjct: 1063 CDSSPCKNGGKCWQTHTQYRCECPSGWT---------------------GLYCDVPSV-- 1099

Query: 2034 TTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPG 2093
                               CE+  Q        LC  G                      
Sbjct: 1100 ------------------SCEVAAQRQGVDVARLCQHG---------------------- 1119

Query: 2094 VCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD-TDECSVGHPCGQG-TCTNVIGGFECA 2151
                G+CV+   +  C C  GY    TG  C D  DECS   PC  G TCT+ +GG+ C 
Sbjct: 1120 ----GLCVDAGNTHHCRCQAGY----TGSYCEDLVDECSPS-PCQNGATCTDYLGGYSCK 1170

Query: 2152 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR-DVDE 2210
            C  G+    +   E+IDEC  +P      C +   +Y C+CP G      G  C  +VD+
Sbjct: 1171 CVAGYHG--VNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRG----TQGVHCEINVDD 1224

Query: 2211 C------ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQP-DL 2262
            C            C   G  C + +G ++C CPPG       GE C  D NEC + P D 
Sbjct: 1225 CNPPVDPVSRSPKCFNNG-TCVDQVGGYSCTCPPGF-----VGERCEGDVNECLSNPCDA 1278

Query: 2263 CVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRA 2322
                 CV     F C+C  G     T   C  +  G                      + 
Sbjct: 1279 RGTQNCVQRVNDFHCECRAGH----TGRRCESVING---------------------CKG 1313

Query: 2323 ECCCGGGRGWGPRCELCPLPGTSA--YRKLCPHG-SGYTAEGRDVDECRMLAHLCAHGEC 2379
            + C  GG         C +   +A  +   CP G  G T E  D   C  L  L   G C
Sbjct: 1314 KPCKNGG--------TCAVASNTARGFICKCPAGFEGATCE-NDARTCGSLRCLNG-GTC 1363

Query: 2380 INSLGSFRCHCQAGYT-PDA---TATTCLDMDECSQVPKPCTFLCKNTKGS--FLCSCPR 2433
            I+   S  C C   +T P+     ++ CL  + C          C+ T  S  + C CP 
Sbjct: 1364 ISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYN-----QGTCEPTSESPFYRCLCPA 1418

Query: 2434 GYLLEEDGRTCKDLD----------------ECTSRQHNCQFLCVNTVGAFTCRCPPGFT 2477
             +    +G  C  LD                E       CQ    N V +  C       
Sbjct: 1419 KF----NGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQC------- 1467

Query: 2478 QHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHR 2537
             +H   +D  +CS             N P     +  Q +   S GH C+  ++C+    
Sbjct: 1468 NNHACGWDGGDCSLN----------FNDPWKNCTQSLQCWKYFSDGH-CD--SQCNSA-- 1512

Query: 2538 CQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASC 2584
               GC     G+ C   +G         C D          C SA C
Sbjct: 1513 ---GC--LFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAEC 1554



 Score =  457 bits (1177), Expect = e-128
 Identities = 492/1745 (28%), Positives = 690/1745 (39%), Gaps = 413/1745 (23%)

Query: 412  CRHFTNLCLNG-RCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIP--- 467
            C      CLNG +C     +  C C   +   V   C D + C S+PC +    ++    
Sbjct: 24   CSQPGETCLNGGKCEAANGTEACVCGGAF---VGPRCQDPNPCLSTPCKNAGTCHVVDRR 80

Query: 468  --GTYHCRCYPGFQA----TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFE 521
                Y C C  GF      TP   AC+  + C  +GG C L     T   ++C C  G+ 
Sbjct: 81   GVADYACSCALGFSGPLCLTPLDNACL-TNPCR-NGGTCDL----LTLTEYKCRCPPGWS 134

Query: 522  LSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC-MDIDEC-QTP 579
                GK+C   + CA++     G CL  + S+ C C P F     G  C  D++EC Q P
Sbjct: 135  ----GKSCQQADPCASNPCANGGQCLPFEASYICHCPPSF----HGPTCRQDVNECGQKP 186

Query: 580  GICVN-GHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCY--------GAIEKGSCA 630
            G+C + G C N  GS+RC             VC  TH    C            + G   
Sbjct: 187  GLCRHGGTCHNEVGSYRC-------------VCRATHTGPNCERPYVPCSPSPCQNGGTC 233

Query: 631  RPFPGTVTKSECCCANPDHGF-GEPCQL----CPAKDSAEFQALCSSGLGITTDG----- 680
            RP  G VT  EC C     GF G+ C+     CP  +       C +G G   DG     
Sbjct: 234  RP-TGDVT-HECACL---PGFTGQNCEENIDDCPGNN-------CKNG-GACVDGVNTYN 280

Query: 681  -------------RDINECALDPEVCAN-GVCENLRGSYRCVCNLGYEAGASGKDCTD-V 725
                          D++EC L P  C N G C N  G Y CVC  G+    +G+DC++ +
Sbjct: 281  CRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGW----TGEDCSENI 336

Query: 726  DECALNSLLCDNG-WCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGV---CR 781
            D+CA  S  C +G  C +   S+ C CP G    +   +C   D C+S+PC  G      
Sbjct: 337  DDCA--SAACFHGATCHDRVASFYCECPHG----RTGLLCHLNDACISNPCNEGSNCDTN 390

Query: 782  NLAGSYTCKCGPGSRLDPSGTFCLDSTK---------GTCWLKIQESRCEVNLQGASLRS 832
             + G   C C P     P+ +  +D            G C   +    C+  LQG +   
Sbjct: 391  PVNGKAICTC-PSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQC-LQGYT-GP 447

Query: 833  ECCATLGAAWGSPCER---C-----EIDPACARGFARMTGVTCD-DVNECESFPGVCPNG 883
             C   +     +PC+    C     E    C  G+    GV C+ + +EC S P    NG
Sbjct: 448  RCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGY---EGVHCEVNTDECASSP-CLHNG 503

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTL----------PGK 933
            RC++    F+CECP G     +G LC          ++D DEC  T           P  
Sbjct: 504  RCLDKINEFQCECPTGF----TGHLC----------QYDVDECASTPCKNGAKCLDGPNT 549

Query: 934  YRMDVCCCSIGAVWGVECEA----CPDPESLEFASLCPRGLGFAS---RDFLSGRPFYKD 986
            Y    C C+ G   G  CE     C DP+   + S C  G+   +   R   +G     +
Sbjct: 550  Y---TCVCTEGYT-GTHCEVDIDEC-DPDPCHYGS-CKDGVATFTCLCRPGYTGHHCETN 603

Query: 987  VNECKVFPGLCTH-GTCRNTVGSFHCACAGGFALDAQERNC-TDIDECRISPDLCGQGTC 1044
            +NEC   P  C H GTC++   ++ C C  G        NC  ++D+C  SP  C  GTC
Sbjct: 604  INECSSQP--CRHGGTCQDRDNAYLCFCLKG----TTGPNCEINLDDCASSP--CDSGTC 655

Query: 1045 VNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHEL 1104
            ++    +EC C PGY +G M   N   +DECA +P    GGTC +    + C+CP G+  
Sbjct: 656  LDKIDGYECACEPGY-TGSMCNIN---IDECAGNP-CHNGGTCEDGINGFTCRCPEGYH- 709

Query: 1105 TAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINECRVQ- 1162
                T   +++EC+ +   C HG C + +  ++C C  G+  T     C ++ NEC    
Sbjct: 710  --DPTCLSEVNECNSNP--CVHGACRDSLNGYKCDCDPGWSGT----NCDINNNECESNP 761

Query: 1163 --NGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGH 1219
              NGG    C +    Y C+C +G+S    G  C  +++EC  NP   +QG C +   G+
Sbjct: 762  CVNGGT---CKDMTSGYVCTCREGFS----GPNCQTNINECASNP-CLNQGTCIDDVAGY 813

Query: 1220 RCLC--------------------------------YDGFMATPDM----RTC-VDVDEC 1242
            +C C                                Y+ F          +TC VD++EC
Sbjct: 814  KCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINEC 873

Query: 1243 DLNPHICLHG-DCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301
             L+P  C HG  C+NT G + CHCQ GY  R   T   D+D+C    + C +  SC +  
Sbjct: 874  VLSP--CRHGASCQNTHGGYRCHCQAGYSGRNCET---DIDDCR--PNPCHNGGSCTDGI 926

Query: 1302 GSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE 1361
             +  C CLPG+ G   E  D++EC S    C    +C +   SY CTC  GF+  G  CE
Sbjct: 927  NTAFCDCLPGFRGTFCE-EDINECASDP--CRNGANCTDCVDSYTCTCPAGFS--GIHCE 981

Query: 1362 DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ-DVDECAQGNLCAFGSCE 1420
            +           + G C++    + C C  GF  +     CQ DV+EC        G+C+
Sbjct: 982  NNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGS----YCQHDVNECDSQPCLHGGTCQ 1037

Query: 1421 NLPGMFRCICNGGYELDRGGGNCTDINECADPVNCIN-GVCINTPGSYLCSCPQDFELNP 1479
            +  G +RC C  GY     G NC ++    D   C N G C  T   Y C CP  +    
Sbjct: 1038 DGCGSYRCTCPQGYT----GPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGW---- 1089

Query: 1480 SGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANT 1539
            +G+ C D  + +C +    +           GV V R    C  G        LC  A  
Sbjct: 1090 TGLYC-DVPSVSCEVAAQRQ-----------GVDVAR---LCQHG-------GLCVDAGN 1127

Query: 1540 TEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQ-GGDCVNTFGSFQCECPPGYHLSE 1598
            T +     G  G      +   + +DEC   P  CQ G  C +  G + C+C  GYH   
Sbjct: 1128 THHCRCQAGYTG------SYCEDLVDECS--PSPCQNGATCTDYLGGYSCKCVAGYH--- 1176

Query: 1599 HTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMD--------MRK 1650
                 E+IDEC +H    G GTC +    Y C CP     V+   N  D         R 
Sbjct: 1177 GVNCSEEIDECLSHPCQNG-GTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRS 1235

Query: 1651 SVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGF 1710
              CF   NGTC                  + Q     C  CP               PGF
Sbjct: 1236 PKCFN--NGTC------------------VDQVGGYSC-TCP---------------PGF 1259

Query: 1711 LTDIHTGKPLDIDECGEIPAICANGI--CINQIGSFRCECPAGFNYNSILLACEDVDECG 1768
            + +   G   D++EC   P   A G   C+ ++  F CEC AG         CE V   G
Sbjct: 1260 VGERCEG---DVNECLSNPC-DARGTQNCVQRVNDFHCECRAGHTGR----RCESVIN-G 1310

Query: 1769 SRESPCQQNADCI---NIPGSYRCKCTRGYKLSPGGACVGRNECREIPNV--CSHGDCMD 1823
             +  PC+    C    N    + CKC  G++   G  C   N+ R   ++   + G C+ 
Sbjct: 1311 CKGKPCKNGGTCAVASNTARGFICKCPAGFE---GATC--ENDARTCGSLRCLNGGTCIS 1365

Query: 1824 TEGSYMCLCHRGFQASADQ----TLCMDIDECDRQPCGNGTCKNIIGS--YNCLCFPGF- 1876
               S  CLC   F     Q    + C+  + C  Q    GTC+    S  Y CLC   F 
Sbjct: 1366 GPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQ----GTCEPTSESPFYRCLCPAKFN 1421

Query: 1877 -VVTH-----NGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQ--------DGFELTA 1922
             ++ H      G     D    L+ + C    C   AG+  C  Q        DG + + 
Sbjct: 1422 GLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSL 1481

Query: 1923 D----GKNCVDTNEC------------LSLAGTCLPG-TCQNLEGSFRCICPPGF-QVQS 1964
            +     KNC  + +C             + AG    G  CQ  EG     C P + Q   
Sbjct: 1482 NFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQ----CNPLYDQYCK 1537

Query: 1965 DHCID 1969
            DH  D
Sbjct: 1538 DHFSD 1542



 Score =  449 bits (1155), Expect = e-125
 Identities = 447/1589 (28%), Positives = 637/1589 (40%), Gaps = 349/1589 (21%)

Query: 1242 CDLNPHICLHGD-CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNI 1300
            C      CL+G  CE   G+  C C   ++  +    C D + C      C +  +C  +
Sbjct: 24   CSQPGETCLNGGKCEAANGTEACVCGGAFVGPR----CQDPNPCL--STPCKNAGTCHVV 77

Query: 1301 P----GSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGD 1356
                   ++C C  G+ G        + C++   R     D L +   Y+C C  G++G 
Sbjct: 78   DRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLT-EYKCRCPPGWSGK 136

Query: 1357 GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFD-PTEDHRACQDVDECAQG-NLC 1414
               C+  D CA N    + GQCL     Y C C   F  PT      QDV+EC Q   LC
Sbjct: 137  S--CQQADPCASN-PCANGGQCLPFEASYICHCPPSFHGPT----CRQDVNECGQKPGLC 189

Query: 1415 AFG-SCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPG--SYLCSC 1471
              G +C N  G +RC+C   +     G NC        P  C NG      G  ++ C+C
Sbjct: 190  RHGGTCHNEVGSYRCVCRATHT----GPNCERPYVPCSPSPCQNGGTCRPTGDVTHECAC 245

Query: 1472 PQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPC 1531
               F          D    NC         +G +C      GV   +C            
Sbjct: 246  LPGFTGQNCEENIDDCPGNNC--------KNGGACVD----GVNTYNC------------ 281

Query: 1532 ELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQ-GGDCVNTFGSFQCEC 1590
              CP   T +Y T                 ED+DECQ +P  CQ GG C NT G + C C
Sbjct: 282  -RCPPEWTGQYCT-----------------EDVDECQLMPNACQNGGTCHNTHGGYNCVC 323

Query: 1591 PPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQV----------- 1639
              G+   + +   E+ID+C++ +   G  TC++ + ++ C CP     +           
Sbjct: 324  VNGWTGEDCS---ENIDDCASAACFHG-ATCHDRVASFYCECPHGRTGLLCHLNDACISN 379

Query: 1640 --NGGNNCMDMR---KSVCF--RHYNG-TCQNEL---------------AFNVTRKMCC- 1675
              N G+NC       K++C     Y G  C  ++                 N      C 
Sbjct: 380  PCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQ 439

Query: 1676 ---------CSYNIGQAWNRPCEACPTPISP--DYQILCGNQAPGFLTDIHTGKPLDIDE 1724
                     C  ++ +  + PC+   T +    ++Q +C     G   +++T      DE
Sbjct: 440  CLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNT------DE 493

Query: 1725 CGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIP 1784
            C   P +  NG C+++I  F+CECP GF  +   L   DVDEC S  +PC+  A C++ P
Sbjct: 494  CASSPCL-HNGRCLDKINEFQCECPTGFTGH---LCQYDVDECAS--TPCKNGAKCLDGP 547

Query: 1785 GSYRCKCTRGYKLSPGGAC-VGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQT 1843
             +Y C CT GY    G  C V  +EC   P+ C +G C D   ++ CLC  G+     +T
Sbjct: 548  NTYTCVCTEGYT---GTHCEVDIDECD--PDPCHYGSCKDGVATFTCLCRPGYTGHHCET 602

Query: 1844 LCMDIDECDRQPCGNG-TCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFG 1901
               +I+EC  QPC +G TC++   +Y C C  G   T   +C ++ D+C +     C  G
Sbjct: 603  ---NINECSSQPCRHGGTCQDRDNAYLCFCLKG---TTGPNCEINLDDCAS---SPCDSG 653

Query: 1902 HCLNTAGSFHCLCQDGFELTADGKNC-VDTNECLSLAGTCLPG-TCQNLEGSFRCICPPG 1959
             CL+    + C C+ G+     G  C ++ +EC      C  G TC++    F C CP G
Sbjct: 654  TCLDKIDGYECACEPGYT----GSMCNINIDECAG--NPCHNGGTCEDGINGFTCRCPEG 707

Query: 1960 FQVQSDHCI-DIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSD-------------- 2004
            +   +  C+ +++EC+  P  C+ G C +S   ++C C PG+  ++              
Sbjct: 708  YHDPT--CLSEVNECNSNP--CVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV 763

Query: 2005 NGHRCFDTRQSFCFTRFEA----------GKCSVPKAFNTT---------KTRCC----- 2040
            NG  C D    +  T  E            +C+     N           K  C      
Sbjct: 764  NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTG 823

Query: 2041 ---------CSKRPGEGWGDPCELCPQ-EGSAAFQELCPFGHGAVPGPDDSREDVNECAE 2090
                     C+  P    G+    C Q E   +F  +CP G            D+NEC  
Sbjct: 824  ATCEVVLAPCAPSPCRNGGE----CRQSEDYESFSCVCPTGWQG----QTCEVDINECVL 875

Query: 2091 NPGVCTNGV-CVNTDGSFRCECPFGYSLDFTGINC-VDTDECSVGHPCGQG-TCTNVIGG 2147
            +P  C +G  C NT G +RC C  GYS    G NC  D D+C   +PC  G +CT+ I  
Sbjct: 876  SP--CRHGASCQNTHGGYRCHCQAGYS----GRNCETDIDDCRP-NPCHNGGSCTDGINT 928

Query: 2148 FECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRD 2207
              C C  GF        EDI+EC+ +P      C +   SY CTCPAG++    G  C +
Sbjct: 929  AFCDCLPGFRGTFCE--EDINECASDPCRNGANCTDCVDSYTCTCPAGFS----GIHCEN 982

Query: 2208 VDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQPDLCVNG 2266
                 D  +     G  C + I +F C+CPPG      +G  C  D NEC +QP L   G
Sbjct: 983  --NTPDCTESSCFNGGTCVDGINSFTCLCPPGF-----TGSYCQHDVNECDSQPCLH-GG 1034

Query: 2267 RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCC 2326
             C +  GS+RC C +G+              GP         C++L    ++      C 
Sbjct: 1035 TCQDGCGSYRCTCPQGYT-------------GP--------NCQNLVHWCDSSP----CK 1069

Query: 2327 GGGRGWGP----RCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGE-CIN 2381
             GG+ W      RCE CP   T  Y  +        A+ + VD    +A LC HG  C++
Sbjct: 1070 NGGKCWQTHTQYRCE-CPSGWTGLYCDVPSVSCEVAAQRQGVD----VARLCQHGGLCVD 1124

Query: 2382 SLGSFRCHCQAGYTPDATATTCLDM-DECSQVPKPCT--FLCKNTKGSFLCSCPRGYLLE 2438
            +  +  C CQAGYT     + C D+ DECS  P PC     C +  G + C C  GY   
Sbjct: 1125 AGNTHHCRCQAGYT----GSYCEDLVDECS--PSPCQNGATCTDYLGGYSCKCVAGY--- 1175

Query: 2439 EDGRTC-KDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGP 2495
              G  C +++DEC S  H CQ    C++    + C CP G TQ      + D+C+    P
Sbjct: 1176 -HGVNCSEEIDECLS--HPCQNGGTCLDLPNTYKCSCPRG-TQGVHCEINVDDCNPPVDP 1231

Query: 2496 ------CGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNEC-DGP--HRCQHGCQNQ 2545
                  C  +G C +  G + C C  GF     G  CE DVNEC   P   R    C  +
Sbjct: 1232 VSRSPKCFNNGTCVDQVGGYSCTCPPGFV----GERCEGDVNECLSNPCDARGTQNCVQR 1287

Query: 2546 LGGYRCSCPQGFTQHSQWAQCVDE-NECALSP----PTCGSASCRNTLGGFRCVCPSGFD 2600
            +  + C C  G T      +C    N C   P     TC  AS  NT  GF C CP+GF+
Sbjct: 1288 VNDFHCECRAGHTGR----RCESVINGCKGKPCKNGGTCAVAS--NTARGFICKCPAGFE 1341

Query: 2601 FDQALGGCQEVD--ECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGP 2658
                 G   E D   C   R     +C + P    C C               LG   GP
Sbjct: 1342 -----GATCENDARTCGSLRCLNGGTCISGPRSPTCLC---------------LGPFTGP 1381

Query: 2659 Q-DTPDKEELLSSEACYE---CKINGLSP 2683
            +   P     L    CY    C+    SP
Sbjct: 1382 ECQFPASSPCLGGNPCYNQGTCEPTSESP 1410



 Score =  337 bits (865), Expect = 8e-92
 Identities = 377/1356 (27%), Positives = 520/1356 (38%), Gaps = 312/1356 (23%)

Query: 51   PGILQGPNVCGSRFHAY---CCPGWRTFPGRSQCVVPICRRACGEG----------FCSQ 97
            P   Q    C +    Y   C  GW T    S+ +      AC  G          +C  
Sbjct: 303  PNACQNGGTCHNTHGGYNCVCVNGW-TGEDCSENIDDCASAACFHGATCHDRVASFYCEC 361

Query: 98   PN-----LCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPI-- 150
            P+     LC   D  ++  C  + GS C  + +NG     A C C  GYTG  C Q +  
Sbjct: 362  PHGRTGLLCHLNDACISNPC--NEGSNCDTNPVNGK----AICTCPSGYTGPACSQDVDE 415

Query: 151  CDRG---CHNGGRCI---GPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLV 204
            C  G   C + G+CI   G   C C+ G+ GP+CE D        +     CQ+  T L 
Sbjct: 416  CSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVN------ECVSNPCQNDATCLD 469

Query: 205  CTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCV 264
                  C  +    G+ CE+                      + DEC + P L   G C+
Sbjct: 470  QIGEFQCICMPGYEGVHCEV----------------------NTDECASSPCL-HNGRCL 506

Query: 265  NMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF--GGRCAGDLAGHYTRRQCCCDRG 322
            + +  F C CP G     +   C+ Y    C S     G +C  D    YT   C C  G
Sbjct: 507  DKINEFQCECPTGF----TGHLCQ-YDVDECASTPCKNGAKCL-DGPNTYT---CVCTEG 557

Query: 323  RCWAAGPVP-ELCPPR---------GSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG 372
                   V  + C P          G   F  LC       PG+ G         +N   
Sbjct: 558  YTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCR------PGYTGHH-----CETNINE 606

Query: 373  PPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYR 432
                P R   HG   +   +        GT   N  I++    ++ C +G CL     Y 
Sbjct: 607  CSSQPCR---HGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYE 663

Query: 433  CECNVGYTQDVRGECIDVDECTSSPCHH-GDCVNIPGTYHCRCYPGFQATPTRQACVDVD 491
            C C  GYT  +    I++DEC  +PCH+ G C +    + CRC  G+   PT     +V+
Sbjct: 664  CACEPGYTGSMCN--INIDECAGNPCHNGGTCEDGINGFTCRCPEGYH-DPT--CLSEVN 718

Query: 492  ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVN-GVCLNE 549
            EC  +   C  G C ++   ++C C+ G+     G NC +++NEC  S  CVN G C + 
Sbjct: 719  EC--NSNPCVHGACRDSLNGYKCDCDPGW----SGTNCDINNNEC-ESNPCVNGGTCKDM 771

Query: 550  DGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGR 609
               + C C+ GF    G +   +I+EC +      G C +    ++C CL    +   G 
Sbjct: 772  TSGYVCTCREGF---SGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCL----LPYTGA 824

Query: 610  VCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQAL 669
             C            +    CA P P         C N     G  C+   ++D   F  +
Sbjct: 825  TC-----------EVVLAPCA-PSP---------CRN-----GGECR--QSEDYESFSCV 856

Query: 670  CSSGLGITTDGRDINECALDPEVCANGV-CENLRGSYRCVCNLGYEAGASGKDC-TDVDE 727
            C +G    T   DINEC L P  C +G  C+N  G YRC C  GY    SG++C TD+D+
Sbjct: 857  CPTGWQGQTCEVDINECVLSP--CRHGASCQNTHGGYRCHCQAGY----SGRNCETDIDD 910

Query: 728  CALNSLLCDNGW-CQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGV-CRNLAG 785
            C  N   C NG  C +   +  C C PGF   + T   +D++EC S PC +G  C +   
Sbjct: 911  CRPNP--CHNGGSCTDGINTAFCDCLPGF---RGTFCEEDINECASDPCRNGANCTDCVD 965

Query: 786  SYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSP 845
            SYTC C  G     SG  C ++T         ES C             C       G  
Sbjct: 966  SYTCTCPAGF----SGIHCENNTP-----DCTESSC--------FNGGTCVD-----GIN 1003

Query: 846  CERCEIDPACARGFARMTGVTCD-DVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDA 904
               C     C  GF   TG  C  DVNEC+S P     G C +  GS+RC CP+G     
Sbjct: 1004 SFTC----LCPPGF---TGSYCQHDVNECDSQP-CLHGGTCQDGCGSYRCTCPQGYTGPN 1055

Query: 905  SGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIG------AVWGVECEACPDPE 958
               L       PC    +  +C  T   +YR   C C  G       V  V CE     +
Sbjct: 1056 CQNLVHWCDSSPC---KNGGKCWQT-HTQYR---CECPSGWTGLYCDVPSVSCEVAAQRQ 1108

Query: 959  SLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFA 1018
             ++ A LC  G                              G C +   + HC C  G+ 
Sbjct: 1109 GVDVARLCQHG------------------------------GLCVDAGNTHHCRCQAGYT 1138

Query: 1019 LDAQERNCTD-IDECRISPDLCGQG-TCVNTPGSFECECFPGYESGFMLMKNCM-DVDEC 1075
                   C D +DEC  SP  C  G TC +  G + C+C  GY        NC  ++DEC
Sbjct: 1139 ----GSYCEDLVDEC--SPSPCQNGATCTDYLGGYSCKCVAGYHG-----VNCSEEIDEC 1187

Query: 1076 ARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDEC-------SLSDGLCPHG 1127
               P    GGTC +   +YKC CP G     +G  CE ++D+C       S S     +G
Sbjct: 1188 LSHPCQ-NGGTCLDLPNTYKCSCPRG----TQGVHCEINVDDCNPPVDPVSRSPKCFNNG 1242

Query: 1128 QCVNVIGAFQCSCHAGFQSTPDRQGCV-DINECRVQNGGCDV----HCINTEGSYRCSCG 1182
             CV+ +G + C+C  GF      + C  D+NEC   +  CD     +C+     + C C 
Sbjct: 1243 TCVDQVGGYSCTCPPGFVG----ERCEGDVNEC--LSNPCDARGTQNCVQRVNDFHCECR 1296

Query: 1183 QGYSLMPDGRACADV-DECEENPRVCDQGH----CTNMPGGHRCLC---YDGFMATPDMR 1234
             G++    GR C  V + C+  P  C  G      +N   G  C C   ++G     D R
Sbjct: 1297 AGHT----GRRCESVINGCKGKP--CKNGGTCAVASNTARGFICKCPAGFEGATCENDAR 1350

Query: 1235 TCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECE-------VG 1287
            TC  +  C LN   C+ G    T     C C           G     EC+       +G
Sbjct: 1351 TCGSL-RC-LNGGTCISGPRSPT-----CLC----------LGPFTGPECQFPASSPCLG 1393

Query: 1288 GHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLD 1323
            G+ C +  +C     S   RCL     +G  CH LD
Sbjct: 1394 GNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILD 1429



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 46/151 (30%), Positives = 57/151 (37%), Gaps = 28/151 (18%)

Query: 100  LCTCADGTLAPSCGVSRGSGCSVSCMNGGTC----RGASCLCQKGYTGTVCGQPI---CD 152
            +C C  G    +C     +  S+ C+NGGTC    R  +CLC   +TG  C  P    C 
Sbjct: 1333 ICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCL 1392

Query: 153  RG--CHNGGRCIGPN-----RCACVYGFMGPQCE-RDYRTGPCFGQVGP----------E 194
             G  C+N G C   +     RC C   F G  C   DY  G   G+  P           
Sbjct: 1393 GGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELP 1452

Query: 195  GCQHQLTGLVCTKALCCATVGRAW-GLPCEL 224
             CQ      VC  +L C      W G  C L
Sbjct: 1453 ECQEDAGNKVC--SLQCNNHACGWDGGDCSL 1481


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  473 bits (1218), Expect = e-133
 Identities = 432/1508 (28%), Positives = 623/1508 (41%), Gaps = 291/1508 (19%)

Query: 1283 ECEVGGHNCDSHASCLNIP-GSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLN- 1340
            +C  G   C +   C+    G+  C+C  G++G+   C   D C  +++RC   G C+  
Sbjct: 27   QCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE--YCQHRDPC--EKNRCQNGGTCVAQ 82

Query: 1341 -VPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQC-LNAPGGYRCECEMGFDPTED 1398
             + G   C C  GF G+         C  +    + G C + +   Y C C++GF   E 
Sbjct: 83   AMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKE- 141

Query: 1399 HRACQDVDECAQGNLCAFGS-CENLPGMFRCICNGGYELDRGGGNC-TDINECADPVNCI 1456
               CQ  D C   + CA GS C  +   F C C  G+     G  C TD+NEC  P +C 
Sbjct: 142  ---CQWTDACLS-HPCANGSTCTTVANQFSCKCLTGFT----GQKCETDVNECDIPGHCQ 193

Query: 1457 NG-VCINTPGSYLCSCPQDFE---LNPSGVGCVDT---RAGNCFLETHDRGDSGISCSAE 1509
            +G  C+N PGSY C CPQ F     +   V C  +     G C       GD    C+  
Sbjct: 194  HGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTC----RQTGDFTFECNCL 249

Query: 1510 IGVGVTRASCCCSLGRAWGNPCE---LCPMANTTEYRTLCPGGEGFQPNRITVILEDIDE 1566
               G   ++C  ++     + C+   +C +     Y   CP     Q        ED+DE
Sbjct: 250  --PGFEGSTCERNIDDCPNHRCQNGGVC-VDGVNTYNCRCPPQWTGQ-----FCTEDVDE 301

Query: 1567 CQELPGLCQ-GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPG-TCYNT 1624
            C   P  CQ GG C N  G + C C  G+   + +   E+ID+C+  S  C PG TC + 
Sbjct: 302  CLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCS---ENIDDCAFAS--CTPGSTCIDR 356

Query: 1625 LGNYTCVCP------------------------AEYLQVNGGNNCM--------DMRKSV 1652
            + +++C+CP                         +   +NG   C         D  + V
Sbjct: 357  VASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDV 416

Query: 1653 --CFRHYNGTCQNE-LAFNVTRKMCC----------CSYNIGQAWNRPCEACPTPISP-- 1697
              C    +  C++     N      C          C  +I +  + PC+   T +    
Sbjct: 417  DECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIG 476

Query: 1698 DYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSI 1757
             +  LC    PGF   +H    L+I+EC   P +  NG C++++  F+C CP GF     
Sbjct: 477  GFTCLC---MPGF-KGVHC--ELEINECQSNPCV-NNGQCVDKVNRFQCLCPPGFTGP-- 527

Query: 1758 LLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVC 1816
               C+ D+D+C S  +PC   A CI+ P  Y C+C  G+     G     N     P+ C
Sbjct: 528  --VCQIDIDDCSS--TPCLNGAKCIDHPNGYECQCATGFT----GVLCEENIDNCDPDPC 579

Query: 1817 SHGDCMDTEGSYMCLCHRGFQASADQTLCMD-IDECDRQPCGN-GTCKNIIGSYNCLCFP 1874
             HG C D   SY C+C+ G+  +    +C D IDEC   PC N G C +++  Y C C P
Sbjct: 580  HHGQCQDGIDSYTCICNPGYMGA----ICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQP 635

Query: 1875 GFVVTHNGDC-VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNC-VDTNE 1932
            G   T   +C ++FD+C +     C  G C++    + C+C  GF     G+ C +D +E
Sbjct: 636  G---TSGVNCEINFDDCAS---NPCIHGICMDGINRYSCVCSPGFT----GQRCNIDIDE 685

Query: 1933 CLSLAGTCLPG-TCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGS 1991
            C S    C  G TC N    FRCICP G    S +   ++EC   P  C+ G CT     
Sbjct: 686  CAS--NPCRKGATCINGVNGFRCICPEGPHHPSCYS-QVNECLSNP--CIHGNCTGGLSG 740

Query: 1992 FQCLCPPGFV-----------LSD---NGHRCFDTRQSF---CFTRFEAGKCSVP----- 2029
            ++CLC  G+V           LS+   NG  C +    +   C   F+   C V      
Sbjct: 741  YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECA 800

Query: 2030 --------KAFNTTKTRCCCSKRPGEGWG-----DPCELCPQEGSAAFQELCPFGHGA-- 2074
                      F+      C    P  G        PC   P E +A  +E   F      
Sbjct: 801  SNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCL 860

Query: 2075 -VPGPDDSR--EDVNECAENPGVCTN-GVCVNTDGSFRCECPFGYSLDFTGINCV-DTDE 2129
              PG    R   D++EC   P  C N G+C NT GS+ CECP G+S    G++C  D D+
Sbjct: 861  CAPGWQGQRCTIDIDECISKP--CMNHGLCHNTQGSYMCECPPGFS----GMDCEEDIDD 914

Query: 2130 CSVGHPCGQG-TCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSY 2188
            C + +PC  G +C + +  F C C  GF      T  D++EC   P      C +   SY
Sbjct: 915  C-LANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQT--DMNECLSEPCKNGGTCSDYVNSY 971

Query: 2189 LCTCPAGYTLREDGAMCRD-VDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSG 2247
             C C AG+    DG  C + ++EC +    C   G  C + I +F+C+CP G      +G
Sbjct: 972  TCKCQAGF----DGVHCENNINECTESS--CF-NGGTCVDGINSFSCLCPVGF-----TG 1019

Query: 2248 EGCTDD-NECHAQPDLCVN-GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVL 2305
              C  + NEC + P  C+N G CV+  G++RC C  G+      T  +   + PC     
Sbjct: 1020 SFCLHEINECSSHP--CLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPC----- 1072

Query: 2306 QTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVD 2365
                ++  +  +    ++C C  G  W      C +P  S             A  R V 
Sbjct: 1073 ----KNKGTCVQKKAESQCLCPSG--WAGA--YCDVPNVSC---------DIAASRRGV- 1114

Query: 2366 ECRMLAHLCAH-GECINSLGSFRCHCQAGYTPDATATTCLD-MDECSQVPKPCTFLCKNT 2423
               ++ HLC H G CIN+  +  C C  GYT     + C + +DEC+  P      C + 
Sbjct: 1115 ---LVEHLCQHSGVCINAGNTHYCQCPLGYT----GSYCEEQLDECASNPCQHGATCSDF 1167

Query: 2424 KGSFLCSCPRGYLLEEDGRTCK-DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQA 2482
             G + C C  GY     G  C+ ++DEC ++       C++ V  F C CPPG       
Sbjct: 1168 IGGYRCECVPGY----QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPG--TRGLL 1221

Query: 2483 CFDN-DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNECDGPHRCQH 2540
            C +N D+C+  P  C   G C +  G + C C  GF    +G  CE D+NEC        
Sbjct: 1222 CEENIDDCARGPH-CLNGGQCMDRIGGYSCRCLPGF----AGERCEGDINECLSNPCSSE 1276

Query: 2541 G---CQNQLGGYRCSCPQGFT-QHSQW-------AQCVDENECALS-----------PP- 2577
            G   C      Y C C   FT +H +          C++   CA++           PP 
Sbjct: 1277 GSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPG 1336

Query: 2578 --------TCGSASCR------NTLGGFRCVCPSGFDFDQ--ALGGCQEVDECAGRRGPC 2621
                    +CG   CR      +T  G RC CPS  D +   A   CQ    C  +R P 
Sbjct: 1337 FSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPP 1396

Query: 2622 SYSCANTP 2629
             YSC   P
Sbjct: 1397 YYSCQCAP 1404



 Score =  465 bits (1196), Expect = e-130
 Identities = 443/1559 (28%), Positives = 633/1559 (40%), Gaps = 307/1559 (19%)

Query: 60   CGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFC----SQPNLCTCADGTLAPSCGVS 115
            C +  HA  C       G   CV         EG C    +    C C +G L   C   
Sbjct: 19   CAAPAHALQCRD-----GYEPCV--------NEGMCVTYHNGTGYCKCPEGFLGEYC--Q 63

Query: 116  RGSGCSVS-CMNGGTCRG------ASCLCQKGYTGTVCGQP-----ICDRGCHNGGRCIG 163
                C  + C NGGTC        A+C C  G+TG  C           R C NGG C  
Sbjct: 64   HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHM 123

Query: 164  PNR----CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWG 219
             +R    C C  GF G +C+    T  C                 C     C TV   + 
Sbjct: 124  LSRDTYECTCQVGFTGKECQ---WTDACLSH-------------PCANGSTCTTVANQFS 167

Query: 220  LPCELCPAQPHPCRRGFIPNIHTG-ACQ-DVDECQAVPGLCQ-GGSCVNMVGSFHCRCPV 276
              C+        C  GF     TG  C+ DV+EC  +PG CQ GG+C+N+ GS+ C+CP 
Sbjct: 168  --CK--------CLTGF-----TGQKCETDVNECD-IPGHCQHGGTCLNLPGSYQCQCPQ 211

Query: 277  GH--RLSDS----SAACEDYRAGACFSV---LFGGRCAGDLAGHYTRRQC-CCDRGRCWA 326
            G   +  DS     A       G C       F   C     G    R    C   RC  
Sbjct: 212  GFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQN 271

Query: 327  AGPVPE-------LCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPAR 379
             G   +        CPP+ + +F   C +                          +    
Sbjct: 272  GGVCVDGVNTYNCRCPPQWTGQF---CTE-------------------------DVDECL 303

Query: 380  LNPHGSDARGIPSLGPGNSNIGTATLN--------QTIDICRHFTNLCLNGRCLPTPSSY 431
            L P+     G  +    N   G   +N        + ID C  F +      C+   +S+
Sbjct: 304  LQPNACQNGG--TCANRNGGYGCVCVNGWSGDDCSENIDDCA-FASCTPGSTCIDRVASF 360

Query: 432  RCECNVGYTQDVRGECIDVDECTSSPCHHG---DCVNIPGTYHCRCYPGFQATPTRQACV 488
             C C  G    +   C   D C S+PCH G   D   + G Y C C  G++     +   
Sbjct: 361  SCMCPEGKAGLL---CHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTE--- 414

Query: 489  DVDECIV--SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVNGV 545
            DVDEC +  S    H G+CVNT+G+F C C  G+     G  C +D NEC +     +  
Sbjct: 415  DVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA----GPRCEMDINECHSDPCQNDAT 470

Query: 546  CLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG 605
            CL++ G F+CLC PGF    G H  ++I+ECQ+     NG C +    F+C C  G    
Sbjct: 471  CLDKIGGFTCLCMPGF---KGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFT-- 525

Query: 606  TDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAE 665
              G VC            I+   C+      +  ++C     DH  G  CQ         
Sbjct: 526  --GPVC-----------QIDIDDCSS--TPCLNGAKCI----DHPNGYECQ--------- 557

Query: 666  FQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTD- 724
                C++G        +I+ C  DP+ C +G C++   SY C+CN GY     G  C+D 
Sbjct: 558  ----CATGFTGVLCEENIDNC--DPDPCHHGQCQDGIDSYTCICNPGY----MGAICSDQ 607

Query: 725  VDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLA 784
            +DEC  +  L D G C +    Y C+C PG     + EI  + D+C S+PC+ G+C +  
Sbjct: 608  IDECYSSPCLND-GRCIDLVNGYQCNCQPGTS-GVNCEI--NFDDCASNPCIHGICMDGI 663

Query: 785  GSYTCKCGPG-----SRLDPSGTFCLDSTKG-TCWLKIQESRCEVNLQGASLRSECCATL 838
              Y+C C PG       +D          KG TC   +   RC +  +G      C + +
Sbjct: 664  NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRC-ICPEGPH-HPSCYSQV 721

Query: 839  GAAWGSPCERCEIDPACARGF--------ARMTGVTCD-DVNECESFPGVCPN-GRCVNT 888
                 +PC    I   C  G         A   G+ C+ D NEC S P  C N G C N 
Sbjct: 722  NECLSNPC----IHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNP--CQNGGTCDNL 775

Query: 889  AGSFRCECPEGLMLDASGRLCVDVRLEPCFLR--WDEDECGVTLPGKYRMDVCCCSIGAV 946
               +RC C +G      G  C  V ++ C      ++  C   + G       C  +   
Sbjct: 776  VNGYRCTCKKGF----KGYNC-QVNIDECASNPCLNQGTCFDDISG-----YTCHCVLPY 825

Query: 947  WGVECE---ACPDPESLEFASLCPRGLGFASRDFL-----SGRPFYKDVNECKVFPGLCT 998
             G  C+   A   P   E A++C     F S   L      G+    D++EC   P +  
Sbjct: 826  TGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCM-N 884

Query: 999  HGTCRNTVGSFHCACAGGFA-LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFP 1057
            HG C NT GS+ C C  GF+ +D +E    DID+C  +P   G G+C++   +F C C P
Sbjct: 885  HGLCHNTQGSYMCECPPGFSGMDCEE----DIDDCLANPCQNG-GSCMDGVNTFSCLCLP 939

Query: 1058 GYESGFMLMKNCMDVDECARDPLLCR-GGTCTNTDGSYKCQCPPGHELTAKGTACE-DID 1115
            G+       K   D++EC  +P  C+ GGTC++   SY C+C  G +    G  CE +I+
Sbjct: 940  GFTGD----KCQTDMNECLSEP--CKNGGTCSDYVNSYTCKCQAGFD----GVHCENNIN 989

Query: 1116 ECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCV-DINECRVQNGGCDVHCINTE 1174
            EC+ S      G CV+ I +F C C  GF  +     C+ +INEC       +  C++  
Sbjct: 990  ECTES-SCFNGGTCVDGINSFSCLCPVGFTGS----FCLHEINECSSHPCLNEGTCVDGL 1044

Query: 1175 GSYRCSCGQGYSLMPDGRACAD-VDECEENPRVCDQGHCTNMPGGHRCLCYDG----FMA 1229
            G+YRCSC  GY+    G+ C   V+ C  +P   ++G C       +CLC  G    +  
Sbjct: 1045 GTYRCSCPLGYT----GKNCQTLVNLCSRSP-CKNKGTCVQKKAESQCLCPSGWAGAYCD 1099

Query: 1230 TPDMRTCVDVDECD-LNPHICLH-GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVG 1287
             P++   +       L  H+C H G C N   +  C C LGY    G+     +DEC   
Sbjct: 1100 VPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY---TGSYCEEQLDEC--A 1154

Query: 1288 GHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRC 1347
             + C   A+C +  G + C C+PG+ G   E +++DEC  Q   C   G C+++   ++C
Sbjct: 1155 SNPCQHGATCSDFIGGYRCECVPGYQGVNCE-YEVDEC--QNQPCQNGGTCIDLVNHFKC 1211

Query: 1348 TCRQGFAGDGFFCEDR-DECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD 1406
            +C  G    G  CE+  D+CA      + GQC++  GGY C C  GF      R   D++
Sbjct: 1212 SCPPGTR--GLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGF---AGERCEGDIN 1266

Query: 1407 ECAQGNLCAFGS--CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCING----VC 1460
            EC      + GS  C  L   + C+C   +     G +C    +    + C+NG    V 
Sbjct: 1267 ECLSNPCSSEGSLDCIQLTNDYLCVCRSAFT----GRHCETFVDVCPQMPCLNGGTCAVA 1322

Query: 1461 INTPGSYLCSCPQDFE-----------LNPSGVGCVDTRAG-NCFLETHDRGDSGISCS 1507
             N P  ++C CP  F                G  CV T +G  CF  +    +SG + S
Sbjct: 1323 SNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASS 1381



 Score =  451 bits (1161), Expect = e-126
 Identities = 454/1616 (28%), Positives = 645/1616 (39%), Gaps = 335/1616 (20%)

Query: 541  CVN-GVCLN-EDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTE--GSFRC 596
            CVN G+C+   +G+  C C  GFL    G YC   D C+       G C      G   C
Sbjct: 35   CVNEGMCVTYHNGTGYCKCPEGFL----GEYCQHRDPCEKNRCQNGGTCVAQAMLGKATC 90

Query: 597  QCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGF-GEPC 655
            +C  G   G D +    +H        +  G+C      T    EC C     GF G+ C
Sbjct: 91   RCASGFT-GEDCQYST-SHPCFVSRPCLNGGTCHMLSRDTY---ECTC---QVGFTGKEC 142

Query: 656  QLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANG-VCENLRGSYRCVCNLGYE 714
            Q   A                         C   P  CANG  C  +   + C C  G+ 
Sbjct: 143  QWTDA-------------------------CLSHP--CANGSTCTTVANQFSCKCLTGF- 174

Query: 715  AGASGKDC-TDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV-DECLS 772
               +G+ C TDV+EC +       G C N PGSY C CP GF      + C  +   C  
Sbjct: 175  ---TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF----TGQYCDSLYVPCAP 227

Query: 773  SPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRS 832
            SPCV+G      G +T +C            CL   +G        S CE N+       
Sbjct: 228  SPCVNGGTCRQTGDFTFECN-----------CLPGFEG--------STCERNI------D 262

Query: 833  ECCATLGAAWGSPCERCEIDPACARGF--------ARMTGVTC-DDVNECESFPGVCPN- 882
            +C          P  RC+    C  G          + TG  C +DV+EC   P  C N 
Sbjct: 263  DC----------PNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNG 312

Query: 883  GRCVNTAGSFRCECPEGLMLD--------------ASGRLCVDVRLEPCFLRWDEDECGV 928
            G C N  G + C C  G   D                G  C+D R+        E + G+
Sbjct: 313  GTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCID-RVASFSCMCPEGKAGL 371

Query: 929  TLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVN 988
                   +D  C S     G  C+   +P + ++   CP+G          G    +DV+
Sbjct: 372  LC----HLDDACISNPCHKGALCDT--NPLNGQYICTCPQG--------YKGADCTEDVD 417

Query: 989  ECKVF-PGLCTH-GTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVN 1046
            EC +     C H G C NT G+FHC C  G+A    E    DI+EC   P      TC++
Sbjct: 418  ECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE---MDINECHSDP-CQNDATCLD 473

Query: 1047 TPGSFECECFPGYESGFMLMKNC-MDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELT 1105
              G F C C PG++       +C ++++EC  +P +   G C +    ++C CPPG    
Sbjct: 474  KIGGFTCLCMPGFKG-----VHCELEINECQSNPCV-NNGQCVDKVNRFQCLCPPGF--- 524

Query: 1106 AKGTACE-DIDECSLSDGLCPHG-QCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQN 1163
              G  C+ DID+CS +   C +G +C++    ++C C  GF      +   + +     +
Sbjct: 525  -TGPVCQIDIDDCSSTP--CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHH 581

Query: 1164 GGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD-VDECEENPRVCDQGHCTNMPGGHRCL 1222
            G C     +   SY C C  GY     G  C+D +DEC  +P + D G C ++  G++C 
Sbjct: 582  GQCQ----DGIDSYTCICNPGYM----GAICSDQIDECYSSPCLND-GRCIDLVNGYQCN 632

Query: 1223 CYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYM------------ 1270
            C  G   T  +   ++ D+C  NP  C+HG C +    + C C  G+             
Sbjct: 633  CQPG---TSGVNCEINFDDCASNP--CIHGICMDGINRYSCVCSPGFTGQRCNIDIDECA 687

Query: 1271 ---VRKGATGCSDVDE----CEVGGH--NCDS-----------HASCLNIPGSFSCRCLP 1310
                RKGAT  + V+     C  G H  +C S           H +C      + C C  
Sbjct: 688  SNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDA 747

Query: 1311 GWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAEN 1369
            GWVG   E  D +EC+S  + C   G C N+   YRCTC++GF   G+ C+ + DECA N
Sbjct: 748  GWVGINCEV-DKNECLS--NPCQNGGTCDNLVNGYRCTCKKGF--KGYNCQVNIDECASN 802

Query: 1370 VDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS-CENLPGM--F 1426
              L + G C +   GY C C + +      + CQ V      N C   + C+  P    +
Sbjct: 803  PCL-NQGTCFDDISGYTCHCVLPY----TGKNCQTVLAPCSPNPCENAAVCKESPNFESY 857

Query: 1427 RCICNGGYELDRGGGNCT-DINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCV 1485
             C+C  G++    G  CT DI+EC       +G+C NT GSY+C CP  F    SG+ C 
Sbjct: 858  TCLCAPGWQ----GQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGF----SGMDC- 908

Query: 1486 DTRAGNCFLETHDRGDS---GISCSAEIGV-GVTRASCCCSLGRAWGNPCELCPMANTTE 1541
            +    +C       G S   G++  + + + G T   C   +      PC+     +   
Sbjct: 909  EEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYV 968

Query: 1542 YRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTR 1601
                C    GF          +I+EC E      GG CV+   SF C CP G+  S    
Sbjct: 969  NSYTCKCQAGFDGVHCE---NNINECTE-SSCFNGGTCVDGINSFSCLCPVGFTGS---- 1020

Query: 1602 IC-EDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR---HY 1657
             C  +I+ECS+H  +   GTC + LG Y C CP  Y     G NC  +  ++C R     
Sbjct: 1021 FCLHEINECSSHPCL-NEGTCVDGLGTYRCSCPLGYT----GKNCQTL-VNLCSRSPCKN 1074

Query: 1658 NGTCQNELAFNVTRKMCCCSYNIGQAW----NRPCEACPTPISPDYQILCGNQAPGFLTD 1713
             GTC  + A       C C      A+    N  C+   +      + LC +        
Sbjct: 1075 KGTCVQKKA----ESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQH-------- 1122

Query: 1714 IHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACED-VDECGSRES 1772
                                +G+CIN   +  C+CP G+  +     CE+ +DEC S  +
Sbjct: 1123 --------------------SGVCINAGNTHYCQCPLGYTGS----YCEEQLDECAS--N 1156

Query: 1773 PCQQNADCINIPGSYRCKCTRGYKLSPGGACVGR-NECREIPNVCSH-GDCMDTEGSYMC 1830
            PCQ  A C +  G YRC+C  GY+   G  C    +EC+  P  C + G C+D    + C
Sbjct: 1157 PCQHGATCSDFIGGYRCECVPGYQ---GVNCEYEVDECQNQP--CQNGGTCIDLVNHFKC 1211

Query: 1831 LCHRGFQASADQTLCMD-IDECDRQP-CGN-GTCKNIIGSYNCLCFPGFVVTHNGDCVDF 1887
             C  G +      LC + ID+C R P C N G C + IG Y+C C PGF         D 
Sbjct: 1212 SCPPGTRG----LLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEG--DI 1265

Query: 1888 DECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNC---VDT---NECLSLAGTCL 1941
            +EC +          C+     + C+C+  F     G++C   VD      CL+  GTC 
Sbjct: 1266 NECLSNPCSSEGSLDCIQLTNDYLCVCRSAF----TGRHCETFVDVCPQMPCLN-GGTC- 1319

Query: 1942 PGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFG-TCTNSPGSFQCLCP--- 1997
                 N+   F C CPPGF      C     C +    C  G  C ++    +C CP   
Sbjct: 1320 -AVASNMPDGFICRCPPGF--SGARC--QSSCGQVK--CRKGEQCVHTASGPRCFCPSPR 1372

Query: 1998 ---PGFVLS--DNGHRCFDTRQ-----SFCFTRFEAGKCSVPKAFNTTKTRCCCSK 2043
                G   S   +G  C   RQ       C   F   +C +  A  +T    C S+
Sbjct: 1373 DCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQ 1428



 Score =  440 bits (1131), Expect = e-122
 Identities = 450/1667 (26%), Positives = 645/1667 (38%), Gaps = 346/1667 (20%)

Query: 1031 ECRISPDLC-GQGTCVNTP-GSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCT 1088
            +CR   + C  +G CV    G+  C+C  G+     L + C   D C ++     GGTC 
Sbjct: 27   QCRDGYEPCVNEGMCVTYHNGTGYCKCPEGF-----LGEYCQHRDPCEKNRCQ-NGGTCV 80

Query: 1089 NTD--GSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVI-GAFQCSCHAGFQ 1145
                 G   C+C  G   T +         C +S      G C  +    ++C+C  GF 
Sbjct: 81   AQAMLGKATCRCASG--FTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFT 138

Query: 1146 STPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC-ADVDECEENP 1204
                 + C   + C          C      + C C  G++    G+ C  DV+EC+   
Sbjct: 139  G----KECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFT----GQKCETDVNECDIPG 190

Query: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFV-- 1262
                 G C N+PG ++C C  GF      + C D       P  C++G      G F   
Sbjct: 191  HCQHGGTCLNLPGSYQCQCPQGFTG----QYC-DSLYVPCAPSPCVNGGTCRQTGDFTFE 245

Query: 1263 CHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDL 1322
            C+C  G+   +G+T   ++D+C    H C +   C++   +++CRC P W G  F   D+
Sbjct: 246  CNCLPGF---EGSTCERNIDDCP--NHRCQNGGVCVDGVNTYNCRCPPQWTGQ-FCTEDV 299

Query: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLC------DNG 1376
            DEC+ Q + C   G C N  G Y C C  G++G        D+C+EN+D C         
Sbjct: 300  DECLLQPNACQNGGTCANRNGGYGCVCVNGWSG--------DDCSENIDDCAFASCTPGS 351

Query: 1377 QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS-CENLP--GMFRCICNGG 1433
             C++    + C C  G      H     +D+    N C  G+ C+  P  G + C C  G
Sbjct: 352  TCIDRVASFSCMCPEGKAGLLCH-----LDDACISNPCHKGALCDTNPLNGQYICTCPQG 406

Query: 1434 YELDRGGGNCT-DINEC--ADPVNCIN-GVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
            Y+    G +CT D++EC  A+   C + G C+NT G++ C C + +    +G  C +   
Sbjct: 407  YK----GADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY----AGPRC-EMDI 457

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGG 1549
              C     D   +  +C  +IG G T   C C  G   G  CEL                
Sbjct: 458  NECH---SDPCQNDATCLDKIG-GFT---CLCMPGFK-GVHCEL---------------- 493

Query: 1550 EGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICE-DIDE 1608
                         +I+ECQ  P     G CV+    FQC CPPG+       +C+ DID+
Sbjct: 494  -------------EINECQSNP-CVNNGQCVDKVNRFQCLCPPGF----TGPVCQIDIDD 535

Query: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNEL--- 1665
            CS+   + G   C +    Y C C   +  V    N  +     C   ++G CQ+ +   
Sbjct: 536  CSSTPCLNG-AKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPC---HHGQCQDGIDSY 591

Query: 1666 --AFNVTRKMCCCSYNIGQAWNRPC--EACPTPISPDYQILCGNQAPGFLTDIHTGKPLD 1721
                N       CS  I + ++ PC  +     +   YQ  C     G   +I      +
Sbjct: 592  TCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEI------N 645

Query: 1722 IDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCI 1781
             D+C   P  C +GIC++ I  + C C  GF      +   D+DEC S  +PC++ A CI
Sbjct: 646  FDDCASNP--CIHGICMDGINRYSCVCSPGFTGQRCNI---DIDECAS--NPCRKGATCI 698

Query: 1782 NIPGSYRCKCTRGYKLSPGGACVGR-NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASA 1840
            N    +RC C  G       +C  + NEC  + N C HG+C      Y CLC  G+    
Sbjct: 699  NGVNGFRCICPEG---PHHPSCYSQVNEC--LSNPCIHGNCTGGLSGYKCLCDAGWVGIN 753

Query: 1841 DQTLCMDIDECDRQPCGN-GTCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVC 1898
             +   +D +EC   PC N GTC N++  Y C C  GF      +C V+ DEC +      
Sbjct: 754  CE---VDKNECLSNPCQNGGTCDNLVNGYRCTCKKGF---KGYNCQVNIDECAS--NPCL 805

Query: 1899 RFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLE--------G 1950
              G C +    + C C     L   GKN      C ++   C P  C+N           
Sbjct: 806  NQGTCFDDISGYTCHC----VLPYTGKN------CQTVLAPCSPNPCENAAVCKESPNFE 855

Query: 1951 SFRCICPPGFQVQSDHC-IDIDECSEEPNLCL-FGTCTNSPGSFQCLCPPGFVLSD---- 2004
            S+ C+C PG+Q Q   C IDIDEC  +P  C+  G C N+ GS+ C CPPGF   D    
Sbjct: 856  SYTCLCAPGWQGQ--RCTIDIDECISKP--CMNHGLCHNTQGSYMCECPPGFSGMDCEED 911

Query: 2005 ----------NGHRCFDTRQSF---CFTRFEAGKCSVP---------------KAFNTTK 2036
                      NG  C D   +F   C   F   KC                    +  + 
Sbjct: 912  IDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSY 971

Query: 2037 TRCCCSKRPGEGWGDPCELCPQ----------EGSAAFQELCPFGHGAVPGPDDSREDVN 2086
            T  C +   G    +    C +          +G  +F  LCP G            ++N
Sbjct: 972  TCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTG----SFCLHEIN 1027

Query: 2087 ECAENPGVCTN-GVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPC-GQGTCTNV 2144
            EC+ +P  C N G CV+  G++RC CP GY    TG NC          PC  +GTC   
Sbjct: 1028 ECSSHP--CLNEGTCVDGLGTYRCSCPLGY----TGKNCQTLVNLCSRSPCKNKGTCVQK 1081

Query: 2145 IGGFECACADGFE------PGLMMTCEDIDECSLNPLLCAFR--CHNTEGSYLCTCPAGY 2196
                +C C  G+       P +           L   LC     C N   ++ C CP GY
Sbjct: 1082 KAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY 1141

Query: 2197 TLREDGAMCRD-VDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCT-DDN 2254
            T    G+ C + +DECA     C   G  C + IG + C C PG +     G  C  + +
Sbjct: 1142 T----GSYCEEQLDECA--SNPCQ-HGATCSDFIGGYRCECVPGYQ-----GVNCEYEVD 1189

Query: 2255 ECHAQPDLCVN-GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLS 2313
            EC  QP  C N G C++    F+C C  G +         D  +GP              
Sbjct: 1190 ECQNQP--CQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGP-------------- 1233

Query: 2314 SSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHL 2373
                 +   +C    G G+  RC    LPG           +G   EG D++EC  L++ 
Sbjct: 1234 ---HCLNGGQCMDRIG-GYSCRC----LPGF----------AGERCEG-DINEC--LSNP 1272

Query: 2374 CAHG---ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP----KPCTFLCKNTKGS 2426
            C+     +CI     + C C++ +T     T    +D C Q+P      C  +  N    
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFTGRHCETF---VDVCPQMPCLNGGTCA-VASNMPDG 1328

Query: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDN 2486
            F+C CP G+     G  C+    C   +      CV+T     C CP       + C   
Sbjct: 1329 FICRCPPGF----SGARCQ--SSCGQVKCRKGEQCVHTASGPRCFCP-----SPRDC--- 1374

Query: 2487 DECSAQPGPCGAHGHCH--NTPGSFRCECHQGFTLVSSGHGCEDVNE------------- 2531
             E      PC   G CH    P  + C+C   F    SG  CE                 
Sbjct: 1375 -ESGCASSPCQHGGSCHPQRQPPYYSCQCAPPF----SGSRCELYTAPPSTPPATCLSQY 1429

Query: 2532 CDGPHR---CQHGCQN---QLGGYRCSCPQGFTQHSQWAQCVDENEC 2572
            C    R   C   C +   Q  G  CS     T  + WA C     C
Sbjct: 1430 CADKARDGVCDEACNSHACQWDGGDCS----LTMENPWANCSSPLPC 1472



 Score =  431 bits (1108), Expect = e-120
 Identities = 419/1519 (27%), Positives = 608/1519 (40%), Gaps = 322/1519 (21%)

Query: 419  CLNGRC--LPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD-CVNIPGTYHCRCY 475
            CLNG    + +  +Y C C VG+T     EC   D C S PC +G  C  +   + C+C 
Sbjct: 115  CLNGGTCHMLSRDTYECTCQVGFTGK---ECQWTDACLSHPCANGSTCTTVANQFSCKCL 171

Query: 476  PGFQATPTRQAC-VDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD-HN 533
             GF    T Q C  DV+EC + G   H G C+N  GS+QC C  GF     G+ C   + 
Sbjct: 172  TGF----TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF----TGQYCDSLYV 223

Query: 534  ECATSTMCVNGVCLNEDG--SFSCLCKPGF---------------------LLAPG---- 566
             CA S  CVNG    + G  +F C C PGF                     +   G    
Sbjct: 224  PCAPSP-CVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTY 282

Query: 567  ---------GHYCM-DIDEC-QTPGICVN-GHCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
                     G +C  D+DEC   P  C N G C N  G + C C+ G + G D    +D 
Sbjct: 283  NCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWS-GDDCSENIDD 341

Query: 615  HV------RSTCYGAIEKGSCARP--FPGTVTK-SECCCANPDHGFGEPCQLCPAKDSAE 665
                     STC   +   SC  P    G +    + C +NP H  G  C   P   + +
Sbjct: 342  CAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHK-GALCDTNPL--NGQ 398

Query: 666  FQALCSSGLGITTDGRDINECAL-DPEVCAN-GVCENLRGSYRCVCNLGYEAGASGKDC- 722
            +   C  G        D++ECA+ +   C + G C N  G++ C C  GY    +G  C 
Sbjct: 399  YICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY----AGPRCE 454

Query: 723  TDVDECALNSLLCDN-GWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCV-SGVC 780
             D++EC  +S  C N   C +  G ++C C PGF   +      +++EC S+PCV +G C
Sbjct: 455  MDINEC--HSDPCQNDATCLDKIGGFTCLCMPGF---KGVHCELEINECQSNPCVNNGQC 509

Query: 781  RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840
             +    + C C PG             T   C + I +      L GA         +  
Sbjct: 510  VDKVNRFQCLCPPG------------FTGPVCQIDIDDCSSTPCLNGAK-------CIDH 550

Query: 841  AWGSPCERCEIDPACARGFARMTGVTCDD-VNECESFPGVCPNGRCVNTAGSFRCECPEG 899
              G  C+       CA GF   TGV C++ ++ C+  P  C +G+C +   S+ C C  G
Sbjct: 551  PNGYECQ-------CATGF---TGVLCEENIDNCD--PDPCHHGQCQDGIDSYTCICNPG 598

Query: 900  LMLDASGRLCVDVRLEPCFLR--WDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDP 957
             M    G +C D +++ C+     ++  C + L   Y+   C C  G   GV CE     
Sbjct: 599  YM----GAICSD-QIDECYSSPCLNDGRC-IDLVNGYQ---CNCQPGTS-GVNCEI---- 644

Query: 958  ESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGF 1017
                                        + ++C   P  C HG C + +  + C C+ GF
Sbjct: 645  ----------------------------NFDDCASNP--CIHGICMDGINRYSCVCSPGF 674

Query: 1018 ALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECECFPGYESGFMLMKNC-MDVDEC 1075
                 +R   DIDEC  +P  C +G TC+N    F C C  G         +C   V+EC
Sbjct: 675  ---TGQRCNIDIDECASNP--CRKGATCINGVNGFRCICPEGPHH-----PSCYSQVNEC 724

Query: 1076 ARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECSLSDGLCPHGQCVNVIG 1134
              +P  C  G CT     YKC C  G      G  CE D +EC LS+     G C N++ 
Sbjct: 725  LSNP--CIHGNCTGGLSGYKCLCDAGW----VGINCEVDKNEC-LSNPCQNGGTCDNLVN 777

Query: 1135 AFQCSCHAGFQSTPDRQGC-VDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRA 1193
             ++C+C  GF+       C V+I+EC          C +    Y C C   Y+    G+ 
Sbjct: 778  GYRCTCKKGFKG----YNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYT----GKN 829

Query: 1194 CADV-DECEENPRVCDQGH-CTNMPG--GHRCLCYDGFMATPDMRTCVDVDECDLNPHIC 1249
            C  V   C  NP  C+    C   P    + CLC  G+      R  +D+DEC   P  C
Sbjct: 830  CQTVLAPCSPNP--CENAAVCKESPNFESYTCLCAPGWQG---QRCTIDIDECISKP--C 882

Query: 1250 L-HGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRC 1308
            + HG C NT+GS++C C  G+    G     D+D+C    + C +  SC++   +FSC C
Sbjct: 883  MNHGLCHNTQGSYMCECPPGF---SGMDCEEDIDDCL--ANPCQNGGSCMDGVNTFSCLC 937

Query: 1309 LPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDR-DECA 1367
            LPG+ GD  +  D++EC+S+   C   G C +   SY C C+ GF  DG  CE+  +EC 
Sbjct: 938  LPGFTGDKCQT-DMNECLSEP--CKNGGTCSDYVNSYTCKCQAGF--DGVHCENNINECT 992

Query: 1368 ENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFR 1427
            E+    + G C++    + C C +GF  +       +++EC+       G+C +  G +R
Sbjct: 993  ES-SCFNGGTCVDGINSFSCLCPVGFTGS---FCLHEINECSSHPCLNEGTCVDGLGTYR 1048

Query: 1428 CICNGGYELDRGGGNC-TDINECADPVNCINGVCINTPGSYLCSCPQDFE---LNPSGVG 1483
            C C  GY     G NC T +N C+       G C+       C CP  +     +   V 
Sbjct: 1049 CSCPLGYT----GKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVS 1104

Query: 1484 CVDTRAGNCFLETHDRGDSGISCSA------EIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
            C    +    L  H    SG+  +A      +  +G T + C   L     NPC+     
Sbjct: 1105 CDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATC 1164

Query: 1538 N--TTEYRTLC-PGGEGFQPNRITVILEDIDECQELPGLCQ-GGDCVNTFGSFQCECPPG 1593
            +     YR  C PG +G           ++DECQ  P  CQ GG C++    F+C CPPG
Sbjct: 1165 SDFIGGYRCECVPGYQGVNCE------YEVDECQNQP--CQNGGTCIDLVNHFKCSCPPG 1216

Query: 1594 YHLSEHTRICED-IDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSV 1652
                    +CE+ ID+C+        G C + +G Y+C C   +                
Sbjct: 1217 ----TRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGER------------ 1260

Query: 1653 CFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEA-----CPTPISPDYQILCGNQA 1707
                                   C  +I +  + PC +     C   ++ DY  +C +  
Sbjct: 1261 -----------------------CEGDINECLSNPCSSEGSLDC-IQLTNDYLCVCRSAF 1296

Query: 1708 PGFLTDIHTGKPLDIDECGEIPAICANG----ICINQIGSFRCECPAGFNYNSILLACED 1763
             G   +        +D C ++P  C NG    +  N    F C CP GF+      +C  
Sbjct: 1297 TGRHCETF------VDVCPQMP--CLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQ 1348

Query: 1764 VDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMD 1823
            V         C++   C++     RC C        G        C   P  C HG    
Sbjct: 1349 V--------KCRKGEQCVHTASGPRCFCPSPRDCESG--------CASSP--CQHGGSCH 1390

Query: 1824 TEGS---YMCLCHRGFQAS 1839
             +     Y C C   F  S
Sbjct: 1391 PQRQPPYYSCQCAPPFSGS 1409



 Score =  369 bits (946), Expect = e-101
 Identities = 420/1508 (27%), Positives = 575/1508 (38%), Gaps = 290/1508 (19%)

Query: 51   PGILQGPNVCGSRFHAYCCPGWRTFPGR--SQCVVPICRRAC-GEGFCSQPN----LCTC 103
            PG  Q    C +   +Y C   + F G+      VP     C   G C Q       C C
Sbjct: 189  PGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 248

Query: 104  ADGTLAPSCGVSRGSGCSVSCMNGGTCRGA----SCLCQKGYTGTVCGQPICD-----RG 154
              G    +C  +     +  C NGG C       +C C   +TG  C + + +       
Sbjct: 249  LPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNA 308

Query: 155  CHNGGRCIGPNR---CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCC 211
            C NGG C   N    C CV G+ G  C  +              C  ++    C   +C 
Sbjct: 309  CQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSC---MC- 364

Query: 212  ATVGRAWGLPCELCPAQ-PHPCRRGFI--------------PNIHTGA--CQDVDEC-QA 253
               G+A GL C L  A   +PC +G +              P  + GA   +DVDEC  A
Sbjct: 365  -PEGKA-GLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMA 422

Query: 254  VPGLCQ-GGSCVNMVGSFHCRCPVGHR--------------LSDSSAACEDYRAG---AC 295
                C+  G CVN  G+FHC C  G+                  + A C D   G    C
Sbjct: 423  NSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLC 482

Query: 296  FSVLFGGRCAGDLAGHYTRRQCCCDRGRCW-AAGPVPELCPPRGSNEFQQL----CAQRL 350
                 G  C  +L  +  +   C + G+C         LCPP  +    Q+    C+   
Sbjct: 483  MPGFKGVHC--ELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSST- 539

Query: 351  PLLPG-----HPGLFPGLLGFGSNGMGPPLGPARLNP----HGSDARGIPSL----GPGN 397
            P L G     HP  +      G  G+         +P    HG    GI S      PG 
Sbjct: 540  PCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGY 599

Query: 398  SNIGTATLNQTIDICRHFTNLCLN-GRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSS 456
                 A  +  ID C  +++ CLN GRC+   + Y+C C  G T  V  E I+ D+C S+
Sbjct: 600  MG---AICSDQIDEC--YSSPCLNDGRCIDLVNGYQCNCQPG-TSGVNCE-INFDDCASN 652

Query: 457  PCHHGDCVNIPGTYHCRCYPGFQATPTRQAC-VDVDECIVSGGLCHLG-RCVNTEGSFQC 514
            PC HG C++    Y C C PGF    T Q C +D+DEC  +   C  G  C+N    F+C
Sbjct: 653  PCIHGICMDGINRYSCVCSPGF----TGQRCNIDIDEC--ASNPCRKGATCINGVNGFRC 706

Query: 515  VCNAGFELSPDGKNCVDH-NECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDI 573
            +C  G    P   +C    NEC  S  C++G C      + CLC  G++   G +  +D 
Sbjct: 707  ICPEG----PHHPSCYSQVNEC-LSNPCIHGNCTGGLSGYKCLCDAGWV---GINCEVDK 758

Query: 574  DECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPF 633
            +EC +      G C N    +RC C  G   G + +V +D    + C   + +G+C    
Sbjct: 759  NECLSNPCQNGGTCDNLVNGYRCTCKKGFK-GYNCQVNIDECASNPC---LNQGTCFDDI 814

Query: 634  PGTVTKSECCCANPDHGFG-----EPCQLCPAKDSA---------EFQALCSSGLGITTD 679
             G      C C  P  G        PC   P +++A          +  LC+ G      
Sbjct: 815  SGYT----CHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRC 870

Query: 680  GRDINECALDPEVCAN-GVCENLRGSYRCVCNLGYEAGASGKDC-TDVDECALNSLLCDN 737
              DI+EC   P  C N G+C N +GSY C C  G+    SG DC  D+D+C  N   C N
Sbjct: 871  TIDIDECISKP--CMNHGLCHNTQGSYMCECPPGF----SGMDCEEDIDDCLANP--CQN 922

Query: 738  GW-CQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVS-GVCRNLAGSYTCKCGPGS 795
            G  C +   ++SC C PGF      +   D++ECLS PC + G C +   SYTCKC  G 
Sbjct: 923  GGSCMDGVNTFSCLCLPGF---TGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAG- 978

Query: 796  RLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPAC 855
                                     CE N+   +  S C        G     C     C
Sbjct: 979  --------------------FDGVHCENNINECT-ESSCFNGGTCVDGINSFSC----LC 1013

Query: 856  ARGFARMTGVTC-DDVNECESFPGVCPN-GRCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
              GF   TG  C  ++NEC S P  C N G CV+  G++RC CP G     +G+ C  + 
Sbjct: 1014 PVGF---TGSFCLHEINECSSHP--CLNEGTCVDGLGTYRCSCPLGY----TGKNCQTL- 1063

Query: 914  LEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFA 973
                                  +++C  S     G   +     +  E   LCP G   A
Sbjct: 1064 ----------------------VNLCSRSPCKNKGTCVQ-----KKAESQCLCPSGWAGA 1096

Query: 974  SRDFLSGRPFYKDVNECKVFPGLCTH-GTCRNTVGSFHCACAGGFALDAQERNCTDIDEC 1032
              D  +            +   LC H G C N   + +C C  G+     E     +DEC
Sbjct: 1097 YCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEE---QLDEC 1153

Query: 1033 RISPDLCGQG-TCVNTPGSFECECFPGYESGFMLMKNC-MDVDECARDPLLCRGGTCTNT 1090
              +P  C  G TC +  G + CEC PGY+       NC  +VDEC   P    GGTC + 
Sbjct: 1154 ASNP--CQHGATCSDFIGGYRCECVPGYQG-----VNCEYEVDECQNQPCQ-NGGTCIDL 1205

Query: 1091 DGSYKCQCPPGHELTAKGTACED-IDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPD 1149
               +KC CPPG     +G  CE+ ID+C+        GQC++ IG + C C  GF     
Sbjct: 1206 VNHFKCSCPPG----TRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAG--- 1258

Query: 1150 RQGCV-DINECRVQ--NGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD-VDECEENPR 1205
             + C  DINEC     +    + CI     Y C C   ++    GR C   VD C + P 
Sbjct: 1259 -ERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFT----GRHCETFVDVCPQMP- 1312

Query: 1206 VCDQGHC---TNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSF 1261
              + G C   +NMP G  C C  GF       +C  V         C  G+ C +T    
Sbjct: 1313 CLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVK--------CRKGEQCVHTASGP 1364

Query: 1262 VCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHD 1321
             C C      R   +GC+    C+ GG +C         P  +SC+C P + G   E + 
Sbjct: 1365 RCFCP---SPRDCESGCAS-SPCQHGG-SCHPQRQ----PPYYSCQCAPPFSGSRCELYT 1415

Query: 1322 LD------ECVSQ----------------EHRCS-PRGDCLNVPGSYRCTCRQGFAGDGF 1358
                     C+SQ                 H C    GDC     +    C        +
Sbjct: 1416 APPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDY 1475

Query: 1359 FCEDRDECAENVD-LCDNGQCL--NAPGGYRCECEMGFDPTEDHRACQDVDECAQGNL-C 1414
                 DE    V+ L DN +C   +    Y   C   F      + C   +EC    L C
Sbjct: 1476 INNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNS-EECGWDGLDC 1534

Query: 1415 AFGSCENL 1422
            A    ENL
Sbjct: 1535 AADQPENL 1542



 Score =  292 bits (748), Expect = 3e-78
 Identities = 272/882 (30%), Positives = 357/882 (40%), Gaps = 132/882 (14%)

Query: 1808 ECREIPNVC-SHGDCMDTE-GSYMCLCHRGFQASADQTLCMDIDECDRQPCGNG-TC--K 1862
            +CR+    C + G C+    G+  C C  GF        C   D C++  C NG TC  +
Sbjct: 27   QCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE----YCQHRDPCEKNRCQNGGTCVAQ 82

Query: 1863 NIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFG---HCLNTAGSFHCLCQDGFE 1919
             ++G   C C  GF      DC         V + C  G   H L+   ++ C CQ GF 
Sbjct: 83   AMLGKATCRCASGFT---GEDCQYSTSHPCFVSRPCLNGGTCHMLSR-DTYECTCQVGFT 138

Query: 1920 LTADGKNCVDTNECLSLAGTCLPG-TCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPN 1978
                GK C  T+ CLS    C  G TC  +   F C C  GF  Q     D++EC    +
Sbjct: 139  ----GKECQWTDACLS--HPCANGSTCTTVANQFSCKCLTGFTGQKCET-DVNECDIPGH 191

Query: 1979 LCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTR--FEAGKCSVPKAFNTTK 2036
                GTC N PGS+QC CP GF     G  C D+    C        G C     F    
Sbjct: 192  CQHGGTCLNLPGSYQCQCPQGFT----GQYC-DSLYVPCAPSPCVNGGTCRQTGDFTFE- 245

Query: 2037 TRCCCSKRPGEGWGDPCEL----CP----QEGSAAFQELCPFGHGAVPGPDDS--REDVN 2086
                C+  PG   G  CE     CP    Q G      +  +     P        EDV+
Sbjct: 246  ----CNCLPGFE-GSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD 300

Query: 2087 ECAENPGVCTNG-VCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVI 2145
            EC   P  C NG  C N +G + C C  G+S D    N    D+C+        TC + +
Sbjct: 301  ECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENI---DDCAFASCTPGSTCIDRV 357

Query: 2146 GGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNT--EGSYLCTCPAGYTLREDGA 2203
              F C C +G + GL+  C   D C  NP      C      G Y+CTCP GY     GA
Sbjct: 358  ASFSCMCPEG-KAGLL--CHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYK----GA 410

Query: 2204 MC-RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQPD 2261
             C  DVDECA    +      +C N  G F C C  G      +G  C  D NECH+ P 
Sbjct: 411  DCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY-----AGPRCEMDINECHSDP- 464

Query: 2262 LCVN-GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT 2320
             C N   C++  G F C C  GF+      E ++ +  PC   V    C       + V 
Sbjct: 465  -CQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPC---VNNGQC------VDKVN 514

Query: 2321 RAECCCGGGRGWGPRCEL----CPLPGTSAYRKLCPHGSGYTAE----------GRDVDE 2366
            R +C C  G   GP C++    C         K   H +GY  +            ++D 
Sbjct: 515  RFQCLCPPGFT-GPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN 573

Query: 2367 CRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLD-MDECSQVPKPCTFLCKNTKG 2425
            C      C HG+C + + S+ C C  GY        C D +DEC   P      C +   
Sbjct: 574  CD--PDPCHHGQCQDGIDSYTCICNPGYM----GAICSDQIDECYSSPCLNDGRCIDLVN 627

Query: 2426 SFLCSCPRGYLLEEDGRTCK-DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQAC- 2483
             + C+C  G      G  C+ + D+C S       +C++ +  ++C C PGFT   Q C 
Sbjct: 628  GYQCNCQPG----TSGVNCEINFDDCASNPC-IHGICMDGINRYSCVCSPGFTG--QRCN 680

Query: 2484 FDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG-C 2542
             D DEC++ P  C     C N    FRC C +G    S       VNEC   + C HG C
Sbjct: 681  IDIDECASNP--CRKGATCINGVNGFRCICPEGPHHPSC---YSQVNECLS-NPCIHGNC 734

Query: 2543 QNQLGGYRCSCPQGFTQHSQWAQC-VDENECALSPPTCGSASCRNTLGGFRCVCPSGFDF 2601
               L GY+C C  G+        C VD+NEC LS P     +C N + G+RC C  GF  
Sbjct: 735  TGGLSGYKCLCDAGWVG----INCEVDKNEC-LSNPCQNGGTCDNLVNGYRCTCKKGFKG 789

Query: 2602 DQALGGCQ-EVDECAGRRGPC--SYSCANTPGGFLCGCPQGY 2640
                  CQ  +DECA    PC    +C +   G+ C C   Y
Sbjct: 790  ----YNCQVNIDECAS--NPCLNQGTCFDDISGYTCHCVLPY 825


>gi|194328809 latent transforming growth factor beta binding protein 3
            isoform 1 [Homo sapiens]
          Length = 1303

 Score =  468 bits (1204), Expect = e-131
 Identities = 321/1010 (31%), Positives = 427/1010 (42%), Gaps = 146/1010 (14%)

Query: 745  GSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTF 803
            G     CP G+     T  C+D++EC +   C  G C N  GSY C C PG  L PS T 
Sbjct: 335  GEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 804  CL---DSTKGTCWLKIQ-ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF 859
            C+      K  C+  +  E +C+  L     R  CC ++G AWG+ C+RC  D   A   
Sbjct: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA--- 450

Query: 860  ARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFL 919
                            F  +CP G+  +   S +    +G   D S  L  D   +P  L
Sbjct: 451  ----------------FKEICPAGKGYHILTSHQTLTIQGES-DFSLFLHPDGPPKPQQL 493

Query: 920  RWD----------EDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969
                         E+E GVT       +               A P PE +   S  P  
Sbjct: 494  PESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPT-ATTTPARPYPELISRPS--PPT 550

Query: 970  LGFASRDFLSGRPFYK-------DVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
            + +   D    R   +       + +EC++   +C HG C      + C C  G+    Q
Sbjct: 551  MRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQ 610

Query: 1023 ERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFML-MKNCMDVDECARDPLL 1081
             R C D++EC   P   G+G C+NT GS+ C C  GY        ++C+D++ECA+  L 
Sbjct: 611  HRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLC 670

Query: 1082 CRGGTCTNTDGSYKCQCPPGHELTA-KGTACEDIDECSLSDGLCPHGQCVNVIGAFQC-S 1139
              GG C N  G YKC C PG+ L A +   CEDIDEC      CP G+C N  G+F+C +
Sbjct: 671  GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIA 729

Query: 1140 CHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDE 1199
            C  G++S      C D+NEC   +      C N  GS+RC+C QGY+  PDGR+C DVDE
Sbjct: 730  CQPGYRS-QGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDE 788

Query: 1200 CEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKG 1259
            CE    VCD G C+N PG  +C C  G+  + D   C D+DECD  P  C+ GDC NT G
Sbjct: 789  CEAGD-VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNG 846

Query: 1260 SFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319
            S+ C C  G+ +  G   C D+DEC      C  H +C N+ GS+ C C  G+     + 
Sbjct: 847  SYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ-DQ 904

Query: 1320 HDLDECVSQEHR--CSPRGD----CLNVPGS----YRCTCRQGFAGDGFFCE-------- 1361
            H  +E     H+  C    D    C +V  +      C C  G AG G  CE        
Sbjct: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLG-AGWGDHCEIYPCPVYS 963

Query: 1362 -----------------------------DRDEC-AENVDLCDNGQCLNAPGGYRCECEM 1391
                                         D DEC     ++C  G+C+N   GY C C+ 
Sbjct: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023

Query: 1392 GFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-----TDI 1446
            GF    +   C DVDEC   + C  G CEN  G +RC C    E       C      D+
Sbjct: 1024 GFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDV 1083

Query: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGC---------VDTRAGNCFLETH 1497
            +EC DP  C  G C+N PGSY C C   +   PSG  C            R   C+ +  
Sbjct: 1084 DECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQ-- 1141

Query: 1498 DRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGE------- 1550
             RG+ G+      G  +T   CCC  GR WG  C  CP      +   CP  +       
Sbjct: 1142 -RGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFW 1197

Query: 1551 -------GFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC 1603
                   G  P       ED DEC+     C  G CV   G   CECP G+ L      C
Sbjct: 1198 DTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARC 1252

Query: 1604 EDIDEC---STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRK 1650
             DIDEC   +    +C    C NT G++ CVC A + +      C+  R+
Sbjct: 1253 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1302



 Score =  388 bits (996), Expect = e-107
 Identities = 330/1098 (30%), Positives = 445/1098 (40%), Gaps = 204/1098 (18%)

Query: 185  GPCFGQVGP-EGC-QHQLTGLVCTKALCCATVGRAWGLP-CELCPA-------QPHP--- 231
            G CF    P + C  + L GL   +  CC ++G AWG   C  CP        +P P   
Sbjct: 277  GRCFQDTLPKQPCGSNPLPGLTKQED-CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRG 335

Query: 232  -----CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286
                 C +G+   +++  CQD++EC A+PG+C+ G C+N  GS+ C CP GH L  S   
Sbjct: 336  EVGADCPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 287  C---EDYRAGACFSVLF-GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEF 342
            C   +      CF ++    +C   L    TR+ CCC  G+ W  G   + CP  G+  F
Sbjct: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW--GARCQRCPTDGTAAF 451

Query: 343  QQLC--AQRLPLLPGHPGL-FPGLLGFG--SNGMGPPL------GPARLNP--HGSDARG 389
            +++C   +   +L  H  L   G   F    +  GPP        P++  P     + RG
Sbjct: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511

Query: 390  IPSLGPGNS--NIGTATLNQTIDICRHFTNLCLNGR------CLPTPSSYRCECNVGYTQ 441
            + +  P +   ++  +    T    R +  L            LP     R    +  TQ
Sbjct: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQ 571

Query: 442  DVRGECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL 499
                   + DEC    + C HG+CV  P  Y C C PG+++ P  + CVDV+EC      
Sbjct: 572  -----VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCG 626

Query: 500  CHLGRCVNTEGSFQCVCNAGFEL--SPDGKNCVDHNECATSTMCVN-GVCLNEDGSFSCL 556
               G C+NT GS+ C CN G+ L     G++CVD NECA   +C + G C+N  G + C 
Sbjct: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCN 686

Query: 557  CKPGF-LLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRC-QCLGGLAVGTDGRVCVDT 614
            C PG+ L A     C DIDEC+ P  C +G C N  GSF+C  C  G      G  C D 
Sbjct: 687  CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDV 745

Query: 615  HVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKD-SAEFQALCSSG 673
            +             CA                     G PC     ++    F+  C+ G
Sbjct: 746  N------------ECAE--------------------GSPCSPGWCENLPGSFRCTCAQG 773

Query: 674  LGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECAL 730
                 DGR   D++EC    +VC NG+C N  GS++C C  GY        C D+DEC  
Sbjct: 774  YAPAPDGRSCLDVDECEAG-DVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF 832

Query: 731  NSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCV---SGVCRNLAGSY 787
             +  C  G C N+ GSY C CP G H       C+D+DEC   P +    G C+NL GSY
Sbjct: 833  PA-ACIGGDCINTNGSYRCLCPQG-HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSY 890

Query: 788  TCKCGPGSRLDPSGTFCLD----STKGTCWLKIQES-RCEVNLQGASLRSECCATLGAAW 842
             C C  G         C +      K  C+L   ++  C+  L     + ECC +LGA W
Sbjct: 891  VCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGW 950

Query: 843  GSPCE--------RCEIDPAC--ARGFARMTGV------TCDDVNECESFPG-VCPNGRC 885
            G  CE          E    C   +G+ +   +         D++EC  F   +C  G+C
Sbjct: 951  GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKC 1010

Query: 886  VNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGA 945
            VNT   + C C +G   D +   CVDV  + C    DE  C        R  VC  + G 
Sbjct: 1011 VNTQPGYECYCKQGFYYDGNLLECVDV--DECL---DESNC--------RNGVCENTRG- 1056

Query: 946  VWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNT 1005
              G  C AC  P     A   P     A R  LS  P   DV+EC+  P  C  G C N 
Sbjct: 1057 --GYRC-ACTPP-----AEYSP-----AQRQCLS--PEEMDVDECQ-DPAACRPGRCVNL 1100

Query: 1006 VGSFHCAC-----AGGFALDAQ------ERNCTDIDEC-------------RISPDLCGQ 1041
             GS+ C C      G    D Q      ER     D C                P L   
Sbjct: 1101 PGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFD 1160

Query: 1042 GTCVNTPGSFECECFPGYESG--------------------FMLMKNCMDVDECARDPLL 1081
              C      +  +C P    G                     +L K   D D    D   
Sbjct: 1161 DCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1220

Query: 1082 CR--GGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC---SLSDGLCPHGQCVNVIGAF 1136
            CR   G C    G   C+CP G +L A    C DIDEC   +    LC   +CVN  G+F
Sbjct: 1221 CRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSF 1280

Query: 1137 QCSCHAGFQSTPDRQGCV 1154
            +C C AGF  +     CV
Sbjct: 1281 RCVCKAGFARSRPHGACV 1298



 Score =  377 bits (967), Expect = e-103
 Identities = 264/786 (33%), Positives = 355/786 (45%), Gaps = 100/786 (12%)

Query: 1276 TGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFE--CHDLDECVSQEHRCS 1333
            T  ++ DEC +  + C  H  C+  P  +SC C PG+        C D++EC ++   C 
Sbjct: 570  TQVTETDECRLNQNIC-GHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEP--CG 626

Query: 1334 P-RGDCLNVPGSYRCTCRQGF----AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCE 1388
            P RG C+N  GSY C C +G+       G  C D +ECA+     D G C+N PG Y+C 
Sbjct: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCN 686

Query: 1389 CEMGFDPTEDHR-ACQDVDECAQGNLCAFGSCENLPGMFRCI-CNGGYELDRGGGNCTDI 1446
            C  G+         C+D+DEC   + C  G CEN PG F+CI C  GY   +GGG C D+
Sbjct: 687  CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDV 745

Query: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISC 1506
            NECA+   C  G C N PGS+ C+C Q +   P G  C+D     C  E  D  D+GI C
Sbjct: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV--DEC--EAGDVCDNGI-C 800

Query: 1507 SAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDE 1566
            S   G       C C                             G+  +R     EDIDE
Sbjct: 801  SNTPG----SFQCQCL---------------------------SGYHLSRDRSHCEDIDE 829

Query: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGP-GTCYNTL 1625
            C + P  C GGDC+NT GS++C CP G+ L    R C+DIDECS    +C P G C N  
Sbjct: 830  C-DFPAACIGGDCINTNGSYRCLCPQGHRLVGG-RKCQDIDECSQDPSLCLPHGACKNLQ 887

Query: 1626 GNYTCVCPAEYLQVNGGNNCMDMR----KSVCFRHYNGT--CQNELAFNVTRKMCCCSYN 1679
            G+Y CVC   +      + C ++     K  C+ +++ T  C + LA NVT++ CCCS  
Sbjct: 888  GSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS-- 945

Query: 1680 IGQAWNRPCEACPTPI--SPDYQILCGNQAPGFLTD---IHTGKPL--DIDECGEIPA-I 1731
            +G  W   CE  P P+  S ++  LC +   G+  D   ++ G P   DIDEC    + I
Sbjct: 946  LGAGWGDHCEIYPCPVYSSAEFHSLCPD-GKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004

Query: 1732 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 1791
            C  G C+N    + C C  GF Y+  LL C DVDEC   ES C +N  C N  G YRC C
Sbjct: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNC-RNGVCENTRGGYRCAC 1062

Query: 1792 TRGYKLSPG-GACVGR-----NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLC 1845
            T   + SP    C+       +EC++ P  C  G C++  GSY C C   +        C
Sbjct: 1063 TPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDC 1121

Query: 1846 -MDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQ----VCR- 1899
             +     +R P     C +  G       P       G  + FD+C    G+     CR 
Sbjct: 1122 QLPESPAERAPERRDVCWSQRGEDGMCAGP-----LAGPALTFDDCCCRQGRGWGAQCRP 1176

Query: 1900 ------FGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFR 1953
                    HC  +    +        L        D++E  S    C+ G C    G   
Sbjct: 1177 CPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAV 1236

Query: 1954 CICPPGFQVQSD--HCIDIDECSE---EPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHR 2008
            C CP GFQ+ +    C+DIDEC E      LC    C N+ GSF+C+C  GF  S     
Sbjct: 1237 CECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGA 1296

Query: 2009 CFDTRQ 2014
            C   R+
Sbjct: 1297 CVPQRR 1302



 Score =  364 bits (934), Expect = e-100
 Identities = 310/1119 (27%), Positives = 440/1119 (39%), Gaps = 262/1119 (23%)

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCC-SLGRAWG-NPCELCPMANTTEYRTLCP 1547
            G CF +T  +      C +    G+T+   CC S+G AWG + C  CP    T  +   P
Sbjct: 277  GRCFQDTLPKQP----CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQK--P 330

Query: 1548 GGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607
            G     P R                           G    +CP GY     T  C+DI+
Sbjct: 331  G-----PVR---------------------------GEVGADCPQGYKRLNSTH-CQDIN 357

Query: 1608 ECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMR---KSVCFRHYNGT--CQ 1662
            EC+   G+C  G C N  G+Y CVCP  +        C+  +   KS+CFR  +    CQ
Sbjct: 358  ECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQ 416

Query: 1663 NELAFNVTRKMCCCSYNIGQAWNRPCEACPT----------PISPDYQILCGNQA----- 1707
            + L   +TR++CCCS  +G+AW   C+ CPT          P    Y IL  +Q      
Sbjct: 417  HPLTTRLTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQG 474

Query: 1708 -PGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYN-------SILL 1759
               F   +H   P    +  E P+         +      + P     +       +   
Sbjct: 475  ESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTT 534

Query: 1760 ACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHG 1819
                  E  SR SP        ++P S         +++P       +ECR   N+C HG
Sbjct: 535  PARPYPELISRPSPPTMRWFLPDLPPS-----RSAVEIAPTQV-TETDECRLNQNICGHG 588

Query: 1820 DCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPC--GNGTCKNIIGSYNCLCFPGF- 1876
            +C+     Y C C+ G+++      C+D++EC+ +PC  G G C N  GSYNC C  G+ 
Sbjct: 589  ECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYR 648

Query: 1877 --VVTHNGDCVDFDECTT--LVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN-CVDTN 1931
              V      CVD +EC    L G     G C+N  G + C C  G+ L A     C D +
Sbjct: 649  LHVGAGGRSCVDLNECAKPHLCGD---GGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCI-CPPGFQVQ-SDHCIDIDECSEEPNLCLFGTCTNSP 1989
            EC     +C  G C+N  GSF+CI C PG++ Q    C D++EC+ E + C  G C N P
Sbjct: 706  ECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA-EGSPCSPGWCENLP 763

Query: 1990 GSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGW 2049
            GSF+C C  G+  + +G  C D  +       EAG                CS  PG   
Sbjct: 764  GSFRCTCAQGYAPAPDGRSCLDVDEC------EAGDVC---------DNGICSNTPG--- 805

Query: 2050 GDPCELCPQEGSAAFQELCPFGHGAVPGPDDSR-EDVNECAENPGVCTNGVCVNTDGSFR 2108
                         +FQ  C  G+      D S  ED++EC + P  C  G C+NT+GS+R
Sbjct: 806  -------------SFQCQCLSGYHL--SRDRSHCEDIDEC-DFPAACIGGDCINTNGSYR 849

Query: 2109 CECPFGYSLDFTGINCVDTDECSVGHP--CGQGTCTNVIGGFECACADGFEPGL-MMTCE 2165
            C CP G+ L   G  C D DECS         G C N+ G + C C +GF P      CE
Sbjct: 850  CLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCE 908

Query: 2166 DID------ECSLN---PLLC--AFRCHNTEGSYLCTCPAG------------YTLREDG 2202
            +++      EC LN    + C      + T+    C+  AG            Y+  E  
Sbjct: 909  EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH 968

Query: 2203 AMC--------------------RDVDECA-----------------------------D 2213
            ++C                    RD+DEC                              D
Sbjct: 969  SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYD 1028

Query: 2214 GQ-----------QDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCT----DDNECHA 2258
            G             + + R   C+N  G + C C P     P   +  +    D +EC  
Sbjct: 1029 GNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ- 1087

Query: 2259 QPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECH---------DIRQGPCFAEVLQTMC 2309
             P  C  GRCVN  GS+RC+C   + P P+  +C            R+  C+++  +   
Sbjct: 1088 DPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGM 1147

Query: 2310 RSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYT----------- 2358
             +   +  A+T  +CCC  GRGWG +C  CP  G  ++   CP     +           
Sbjct: 1148 CAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLLL 1204

Query: 2359 --------AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECS 2410
                    +   D DECR     C  G C+   G   C C  G+  DA+   C+D+DEC 
Sbjct: 1205 GKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECR 1259

Query: 2411 QVPKPCTFLCK-----NTKGSFLCSCPRGYLLEEDGRTC 2444
            ++ +    LCK     NT GSF C C  G+        C
Sbjct: 1260 ELNQR-GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297



 Score =  333 bits (855), Expect = 1e-90
 Identities = 225/739 (30%), Positives = 312/739 (42%), Gaps = 114/739 (15%)

Query: 1969 DIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
            + DEC    N+C  G C   P  + C C PG+        C D  +       EA  C  
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC------EAEPCGP 627

Query: 2029 PK--AFNTTKT-RCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSR--- 2082
             +    NT  +  C C++      G     C      A   LC  G   +  P   +   
Sbjct: 628  GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687

Query: 2083 --------------EDVNECAENPGVCTNGVCVNTDGSFRC-ECPFGYSLDFTGINCVDT 2127
                          ED++EC  +P  C +G C N  GSF+C  C  GY     G  C D 
Sbjct: 688  YPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDV 745

Query: 2128 DECSVGHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECSLNPLLCAFRCHNTEG 2186
            +EC+ G PC  G C N+ G F C CA G+ P     +C D+DEC    +     C NT G
Sbjct: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805

Query: 2187 SYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGS 2246
            S+ C C +GY L  D + C D+DEC D    C   G +C N  G++ C+CP G R +   
Sbjct: 806  SFQCQCLSGYHLSRDRSHCEDIDEC-DFPAAC--IGGDCINTNGSYRCLCPQGHRLV--G 860

Query: 2247 GEGCTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ----GPCF 2301
            G  C D +EC   P LC+ +G C N  GS+ C CDEGF P+     C ++ Q      C+
Sbjct: 861  GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECY 920

Query: 2302 AEVLQTM-CRSLSSSSEAVTRAECCCGGGRGWGPRCEL--CPLPGTSAYRKLCPHGSGYT 2358
                 T+ C S+ +++  VT+ ECCC  G GWG  CE+  CP+  ++ +  LCP G GYT
Sbjct: 921  LNFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYT 978

Query: 2359 AEG----------RDVDECRML-AHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMD 2407
             +           RD+DEC +  + +C  G+C+N+   + C+C+ G+  D     C+D+D
Sbjct: 979  QDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVD 1038

Query: 2408 ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC-----KDLDECTSRQHNCQFLCV 2462
            EC         +C+NT+G + C+C          R C      D+DEC          CV
Sbjct: 1039 ECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCV 1098

Query: 2463 NTVGAFTCRCPPGFT-------------------QHHQACFDN----------------- 2486
            N  G++ C C P +                    +    C+                   
Sbjct: 1099 NLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALT 1158

Query: 2487 -DECSAQPG--------PC---GAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG 2534
             D+C  + G        PC   GA  HC  +             L+      ED +E D 
Sbjct: 1159 FDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDS 1218

Query: 2535 PH-RCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECA---LSPPTCGSASCRNTLG 2589
               RC  G C  + GG  C CP GF   +  A+CVD +EC         C S  C NT G
Sbjct: 1219 DECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSG 1278

Query: 2590 GFRCVCPSGFDFDQALGGC 2608
             FRCVC +GF   +  G C
Sbjct: 1279 SFRCVCKAGFARSRPHGAC 1297



 Score =  312 bits (799), Expect = 3e-84
 Identities = 309/1077 (28%), Positives = 397/1077 (36%), Gaps = 211/1077 (19%)

Query: 426  PTPSSYRCECNVGYTQDVRGECIDVDECTS-SPCHHGDCVNIPGTYHCRCYPGFQATPTR 484
            P       +C  GY +     C D++EC     C HGDC+N PG+Y C C PG    P+R
Sbjct: 332  PVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 485  QACV-DVDECIVSGGLCHLGRCVNTEGSFQ-----------CVCNAGFELSPDGKNCVDH 532
              C+ D  E      LC   R V+ E   Q           C C+ G       + C   
Sbjct: 392  TQCIADKPE---EKSLCF--RLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTD 446

Query: 533  NECATSTMCVNGVCLNEDGSFSCLCKPG------FLLAPGGHYCMDIDECQTPGICVNGH 586
               A   +C  G   +   S   L   G      FL   G      + E  +P       
Sbjct: 447  GTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE--SPSQAPPPE 504

Query: 587  CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
             T  E            V TD  V  +  V+ +   A    + ARP+P  +++     + 
Sbjct: 505  DTEEERG----------VTTDSPVSEERSVQQSHPTATT--TPARPYPELISRP----SP 548

Query: 647  PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYR 706
            P   +  P  L P++ + E            T   + +EC L+  +C +G C      Y 
Sbjct: 549  PTMRWFLP-DLPPSRSAVEIAP---------TQVTETDECRLNQNICGHGECVPGPPDYS 598

Query: 707  CVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGF--HFWQDTEIC 764
            C CN GY +    + C DV+EC         G C N+ GSY+C C  G+  H       C
Sbjct: 599  CHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC 658

Query: 765  KDVDECLSSPCV--SGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822
             D++EC         G C N  G Y C C PG RL  S                +   CE
Sbjct: 659  VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS----------------RPPVCE 702

Query: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDP------ACARGFARMTGVTCDDVNEC-ES 875
             ++      S C          P  +CE  P      AC  G+    G  C DVNEC E 
Sbjct: 703  -DIDECRDPSSC----------PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751

Query: 876  FPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYR 935
             P  C  G C N  GSFRC C +G      GR C+DV         DE E G        
Sbjct: 752  SP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV---------DECEAG-------- 792

Query: 936  MDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPG 995
             DVC   I       C   P      F   C  G    SRD    R   +D++EC  FP 
Sbjct: 793  -DVCDNGI-------CSNTPG----SFQCQCLSGY-HLSRD----RSHCEDIDECD-FPA 834

Query: 996  LCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTCVNTPGSFECE 1054
             C  G C NT GS+ C C  G  L    R C DIDEC   P LC   G C N  GS+ C 
Sbjct: 835  ACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV 893

Query: 1055 CFPGYESGFMLMKNCMDVD------EC---ARDPLLCRGGTCTN---------------- 1089
            C  G+ +       C +V+      EC     D + C     TN                
Sbjct: 894  CDEGF-TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD 952

Query: 1090 ----------TDGSYKCQCPPGHELTAKGT-------ACEDIDECSL-SDGLCPHGQCVN 1131
                      +   +   CP G   T           A  DIDEC L    +C  G+CVN
Sbjct: 953  HCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVN 1012

Query: 1132 VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG 1191
                ++C C  GF    +   CVD++EC  ++   +  C NT G YRC+C       P  
Sbjct: 1013 TQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQ 1072

Query: 1192 RAC-----ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC----VDVDEC 1242
            R C      DVDEC++ P  C  G C N+PG +RC C   ++  P  R C       +  
Sbjct: 1073 RQCLSPEEMDVDECQD-PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA 1131

Query: 1243 DLNPHIC--LHGDCENTKGSFV--------CHCQLGYMVRKGATGCSDVDECEVGGHNCD 1292
                 +C    G+     G           C C+ G   R     C        G H C 
Sbjct: 1132 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG---RGWGAQCRPCPPRGAGSH-CP 1187

Query: 1293 SHASCLNIPGSFSCRCL--PGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCR 1350
            +  S  N     S   L  P    D  E  D DEC     RC PR      PG   C C 
Sbjct: 1188 TSQSESNSFWDTSPLLLGKPPRDEDSSE-EDSDECRCVSGRCVPR------PGGAVCECP 1240

Query: 1351 QGFAGDG--FFCEDRDECAENVD---LCDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402
             GF  D     C D DEC E      LC + +C+N  G +RC C+ GF  +  H AC
Sbjct: 1241 GGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297



 Score =  301 bits (770), Expect = 8e-81
 Identities = 220/766 (28%), Positives = 308/766 (40%), Gaps = 164/766 (21%)

Query: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCT 1986
            +T+EC      C  G C      + C C PG++    H  C+D++EC  EP     G C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 1987 NSPGSFQCLCPPGFVL--SDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKR 2044
            N+ GS+ C C  G+ L     G  C D  +                          C+K 
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE--------------------------CAKP 667

Query: 2045 PGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTD 2104
               G G  C   P      ++  C  G+          ED++EC + P  C +G C N  
Sbjct: 668  HLCGDGGFCINFPGH----YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722

Query: 2105 GSFRC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-M 2162
            GSF+C  C  GY     G  C D +EC+ G PC  G C N+ G F C CA G+ P     
Sbjct: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781

Query: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222
            +C D+DEC    +     C NT GS+ C C +GY L  D + C D+DEC D    C   G
Sbjct: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACI--G 838

Query: 2223 MECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDE 2281
             +C N  G++ C+CP G R +   G  C D +EC   P LC+ +G C N  GS+ C CDE
Sbjct: 839  GDCINTNGSYRCLCPQGHRLV--GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896

Query: 2282 GFQPSPTLTECHDIRQG----PCFAEVLQTM-CRSLSSSSEAVTRAECCCGGGRGWGPRC 2336
            GF P+     C ++ Q      C+     T+ C S+ +++  VT+ ECCC  G GWG  C
Sbjct: 897  GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHC 954

Query: 2337 EL--CPLPGTSAYRKLCPHGSGYTAEG----------RDVDECRML-AHLCAHGECINSL 2383
            E+  CP+  ++ +  LCP G GYT +           RD+DEC +  + +C  G+C+N+ 
Sbjct: 955  EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQ 1014

Query: 2384 GSFRCHCQAGYTPDATATTCLDMDEC---------------------------------- 2409
              + C+C+ G+  D     C+D+DEC                                  
Sbjct: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074

Query: 2410 -----------SQVPKPCT-FLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC 2457
                        Q P  C    C N  GS+ C C   ++    GR C+  +    R    
Sbjct: 1075 CLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPER 1134

Query: 2458 QFLCVNTVGAF-TCRCP---PGFTQHHQACFDNDECSAQPGPC-----GAH--------- 2499
            + +C +  G    C  P   P  T     C       AQ  PC     G+H         
Sbjct: 1135 RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESN 1194

Query: 2500 -------------------------------GHCHNTPGSFRCECHQGFTLVSSGHGCED 2528
                                           G C   PG   CEC  GF L +S   C D
Sbjct: 1195 SFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVD 1254

Query: 2529 VNECDGPHR----CQ-HGCQNQLGGYRCSCPQGFTQHSQWAQCVDE 2569
            ++EC   ++    C+   C N  G +RC C  GF +      CV +
Sbjct: 1255 IDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ 1300



 Score =  237 bits (605), Expect = 1e-61
 Identities = 177/540 (32%), Positives = 226/540 (41%), Gaps = 91/540 (16%)

Query: 2166 DIDECSLNPLLCAF-RCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGME 2224
            + DEC LN  +C    C      Y C C  GY        C DV+EC + +     RG+ 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC-EAEPCGPGRGI- 631

Query: 2225 CKNLIGTFACVCPPGMRPLPGSG-EGCTDDNECHAQPDLCVNGR-CVNTAGSFRCDCDEG 2282
            C N  G++ C C  G R   G+G   C D NEC A+P LC +G  C+N  G ++C+C  G
Sbjct: 632  CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPG 690

Query: 2283 FQPSPTLTE-CHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPL 2341
            ++   +    C DI +           CR  SS           C  G+     CE    
Sbjct: 691  YRLKASRPPVCEDIDE-----------CRDPSS-----------CPDGK-----CE--NK 721

Query: 2342 PGTSAYRKLCPHGSGYTAEG----RDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPD 2397
            PG+       P   GY ++G    RDV+EC      C+ G C N  GSFRC C  GY P 
Sbjct: 722  PGSFKCIACQP---GYRSQGGGACRDVNECAE-GSPCSPGWCENLPGSFRCTCAQGYAPA 777

Query: 2398 ATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC 2457
                +CLD+DEC         +C NT GSF C C  GY L  D   C+D+DEC       
Sbjct: 778  PDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI 837

Query: 2458 QFLCVNTVGAFTCRCPPGFTQ-HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQG 2516
               C+NT G++ C CP G      + C D DECS  P  C  HG C N  GS+ C C +G
Sbjct: 838  GGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897

Query: 2517 FTLVSSGHGCEDVNECDGPHRC-------------------QHGCQNQLGG--------Y 2549
            FT     HGCE+V +      C                   Q  C   LG         Y
Sbjct: 898  FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIY 957

Query: 2550 RCS----------CP--QGFTQHSQWAQCV-----DENECAL-SPPTCGSASCRNTLGGF 2591
             C           CP  +G+TQ +           D +EC L     C    C NT  G+
Sbjct: 958  PCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGY 1017

Query: 2592 RCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGC-PQGYFRAGQGHCVS 2650
             C C  GF +D  L  C +VDEC       +  C NT GG+ C C P   +   Q  C+S
Sbjct: 1018 ECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLS 1077



 Score =  195 bits (495), Expect = 6e-49
 Identities = 131/389 (33%), Positives = 178/389 (45%), Gaps = 47/389 (12%)

Query: 2237 PPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296
            PP    +  +    T+ +EC    ++C +G CV     + C C+ G++  P    C D+ 
Sbjct: 559  PPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN 618

Query: 2297 QGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHG-- 2354
            +  C AE                      CG GRG      +C   G S Y   C  G  
Sbjct: 619  E--CEAEP---------------------CGPGRG------ICMNTGGS-YNCHCNRGYR 648

Query: 2355 SGYTAEGR---DVDECRMLAHLCAHGE-CINSLGSFRCHCQAGYTPDAT-ATTCLDMDEC 2409
                A GR   D++EC    HLC  G  CIN  G ++C+C  GY   A+    C D+DEC
Sbjct: 649  LHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDEC 707

Query: 2410 SQVPKPCTFLCKNTKGSFLC-SCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAF 2468
                      C+N  GSF C +C  GY   + G  C+D++EC          C N  G+F
Sbjct: 708  RDPSSCPDGKCENKPGSFKCIACQPGY-RSQGGGACRDVNECAEGSPCSPGWCENLPGSF 766

Query: 2469 TCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGC 2526
             C C  G+      ++C D DEC A  G    +G C NTPGSF+C+C  G+ L      C
Sbjct: 767  RCTCAQGYAPAPDGRSCLDVDECEA--GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHC 824

Query: 2527 EDVNECDGPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTC-GSASC 2584
            ED++ECD P  C  G C N  G YRC CPQG  +     +C D +EC+  P  C    +C
Sbjct: 825  EDIDECDFPAACIGGDCINTNGSYRCLCPQGH-RLVGGRKCQDIDECSQDPSLCLPHGAC 883

Query: 2585 RNTLGGFRCVCPSGFDFDQALGGCQEVDE 2613
            +N  G + CVC  GF   Q   GC+EV++
Sbjct: 884  KNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912



 Score =  162 bits (409), Expect = 6e-39
 Identities = 191/766 (24%), Positives = 261/766 (34%), Gaps = 190/766 (24%)

Query: 38   EAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGR--------SQCVVPICRRA 89
            E  GPGR       GI       G  ++ +C  G+R   G         ++C  P     
Sbjct: 623  EPCGPGR-------GICMNT---GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP---HL 669

Query: 90   CGEG-FCSQ---PNLCTCADGTLAPSCGVSRGSGCSV--SCMNGGTCRGASC-------- 135
            CG+G FC        C C  G    +   SR   C     C +  +C    C        
Sbjct: 670  CGDGGFCINFPGHYKCNCYPGYRLKA---SRPPVCEDIDECRDPSSCPDGKCENKPGSFK 726

Query: 136  --LCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQ-VG 192
               CQ GY     G       C  G  C  P  C  + G     C + Y   P     + 
Sbjct: 727  CIACQPGYRSQGGGACRDVNECAEGSPC-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785

Query: 193  PEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQ 252
             + C+    G VC   +C  T G      C+        C  G+  +     C+D+DEC 
Sbjct: 786  VDECE---AGDVCDNGICSNTPG---SFQCQ--------CLSGYHLSRDRSHCEDIDECD 831

Query: 253  AVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA-----------GACFSVLFG 301
              P  C GG C+N  GS+ C CP GHRL      C+D              GAC ++   
Sbjct: 832  -FPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGS 889

Query: 302  GRCAGD-------------------------------------LAGHYTRRQCCCDRGRC 324
              C  D                                     LA + T+++CCC  G  
Sbjct: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 949

Query: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG 384
            W        CP   S EF  LC                           P G      + 
Sbjct: 950  WGDHCEIYPCPVYSSAEFHSLC---------------------------PDGKGYTQDNN 982

Query: 385  SDARGIPSLGPGNSNIGTATLNQTIDICRHF-TNLCLNGRCLPTPSSYRCECNVGYTQDV 443
                GIP+             ++ ID C  F + +C  G+C+ T   Y C C  G+  D 
Sbjct: 983  IVNYGIPA-------------HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDG 1029

Query: 444  R-GECIDVDEC-TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQAC-----VDVDECIVS 496
               EC+DVDEC   S C +G C N  G Y C C P  + +P ++ C     +DVDEC   
Sbjct: 1030 NLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QD 1088

Query: 497  GGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCL 556
               C  GRCVN  GS++C C   +   P G++C      A        VC ++ G     
Sbjct: 1089 PAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRG----- 1143

Query: 557  CKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHV 616
             + G    P     +  D+C          C      +  QC      G  G  C  +  
Sbjct: 1144 -EDGMCAGPLAGPALTFDDC----------CCRQGRGWGAQCRPCPPRGA-GSHCPTSQS 1191

Query: 617  RSTCYGAIEKGSCARP----FPGTVTKSECCCAN----PDHGFGEPCQLCPAKDSAEFQA 668
             S  +         +P            EC C +    P  G G  C+ CP      FQ 
Sbjct: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPG-GAVCE-CP----GGFQL 1245

Query: 669  LCSSGLGITTDG-RDINECALDPEVCANGVCENLRGSYRCVCNLGY 713
              S    +  D  R++N+  L   +C +  C N  GS+RCVC  G+
Sbjct: 1246 DASRARCVDIDECRELNQRGL---LCKSERCVNTSGSFRCVCKAGF 1288



 Score =  108 bits (271), Expect = 6e-23
 Identities = 149/592 (25%), Positives = 202/592 (34%), Gaps = 139/592 (23%)

Query: 19   AWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFP-G 77
            ++  + C  G + +  GA             SPG  +  N+ GS F   C  G+   P G
Sbjct: 724  SFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE--NLPGS-FRCTCAQGYAPAPDG 780

Query: 78   RSQCVVPICRRA--CGEGFCSQPN---LCTCADGTLAPS----CGVSRGSGCSVSCMNGG 128
            RS   V  C     C  G CS       C C  G         C          +C+ GG
Sbjct: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GG 839

Query: 129  TCRGAS----CLCQKGYT---GTVCGQPI--CDRG---CHNGGRCI---GPNRCACVYGF 173
             C   +    CLC +G+    G  C Q I  C +    C   G C    G   C C  GF
Sbjct: 840  DCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898

Query: 174  MGPQ-------CERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
               Q        E+ +    C+           +     T+  CC ++G  WG  CE+ P
Sbjct: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958

Query: 227  AQPH---------PCRRGF-----IPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGSFH 271
               +         P  +G+     I N    A +D+DEC      +C+ G CVN    + 
Sbjct: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018

Query: 272  CRCPVGHRLSDSSAACEDY---------RAGACFSVLFGGRCAGDLAGHYT--RRQC--- 317
            C C  G     +   C D          R G C +   G RCA      Y+  +RQC   
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSP 1078

Query: 318  ------------CCDRGRC--------------WAAGPVPELC-----PPRGSNEFQQLC 346
                         C  GRC              W  GP    C     P   + E + +C
Sbjct: 1079 EEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVC 1138

Query: 347  -AQRLPLLPGHPGLFPGLLGFGS-----------NGMGPPLGPARLNPHGSDARGIPSLG 394
             +QR     G  G+  G L   +            G G    P    P G+ +    S  
Sbjct: 1139 WSQR-----GEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPC--PPRGAGSHCPTSQS 1191

Query: 395  PGNSNIGTATL------------NQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQD 442
              NS   T+ L             +  D CR     C++GRC+P P    CEC  G+  D
Sbjct: 1192 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLD 1246

Query: 443  V-RGECIDVDECTSSP-----CHHGDCVNIPGTYHCRCYPGFQATPTRQACV 488
              R  C+D+DEC         C    CVN  G++ C C  GF  +    ACV
Sbjct: 1247 ASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298



 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 94/335 (28%), Positives = 120/335 (35%), Gaps = 88/335 (26%)

Query: 58  NVCGSR--------FHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLA 109
           N+CG          +  +C PG+R+ P    CV                N C       A
Sbjct: 583 NICGHGECVPGPPDYSCHCNPGYRSHPQHRYCV--------------DVNECE------A 622

Query: 110 PSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTV------------CGQPICDRGCHN 157
             CG  RG      CMN G     +C C +GY   V            C +P     C +
Sbjct: 623 EPCGPGRG-----ICMNTG--GSYNCHCNRGYRLHVGAGGRSCVDLNECAKP---HLCGD 672

Query: 158 GGRCI---GPNRCACVYGF-----MGPQCE-----RDYRT---GPCFGQVGPEGCQHQLT 201
           GG CI   G  +C C  G+       P CE     RD  +   G C  + G   C     
Sbjct: 673 GGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQP 732

Query: 202 GLVCTKALCCATVGR-AWGLPCE--LCPAQPH----PCRRGFIPNIHTGACQDVDECQAV 254
           G        C  V   A G PC    C   P      C +G+ P     +C DVDEC+A 
Sbjct: 733 GYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA- 791

Query: 255 PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTR 314
             +C  G C N  GSF C+C  G+ LS   + CED       +   GG C  +  G Y  
Sbjct: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI-NTNGSY-- 848

Query: 315 RQCCCDRGRCWAAG----------PVPELCPPRGS 339
            +C C +G     G            P LC P G+
Sbjct: 849 -RCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGA 882



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 44/137 (32%), Positives = 62/137 (45%), Gaps = 29/137 (21%)

Query: 2472 CPPGFTQHHQA-CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGC---- 2526
            CP G+ + +   C D +EC A PG C  HG C N PGS+RC C  G +L  S   C    
Sbjct: 341  CPQGYKRLNSTHCQDINEC-AMPGVC-RHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 2527 -EDVNEC----DGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGS 2581
             E+ + C       H+CQH    +L    C C  G    ++  +C          PT G+
Sbjct: 399  PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRC----------PTDGT 448

Query: 2582 ASCRNTLGGFRCVCPSG 2598
            A+       F+ +CP+G
Sbjct: 449  AA-------FKEICPAG 458



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 36/104 (34%), Positives = 46/104 (44%), Gaps = 19/104 (18%)

Query: 124 CMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYR 183
           C   G CR   CL   G    VC            G  +GP+R  C+        ++   
Sbjct: 359 CAMPGVCRHGDCLNNPGSYRCVCPP----------GHSLGPSRTQCI-------ADKPEE 401

Query: 184 TGPCFGQVGPE-GCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
              CF  V PE  CQH LT  + T+ LCC +VG+AWG  C+ CP
Sbjct: 402 KSLCFRLVSPEHQCQHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 70/296 (23%), Positives = 84/296 (28%), Gaps = 109/296 (36%)

Query: 90   CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQP 149
            C +GF    NL  C D                  C++   CR   C   +G     C  P
Sbjct: 1021 CKQGFYYDGNLLECVDVD---------------ECLDESNCRNGVCENTRGGYRCACTPP 1065

Query: 150  I-------------------C-DRGCHNGGRCI---GPNRCAC----VYGFMGPQCE--- 179
                                C D      GRC+   G  RC C    V G  G  C+   
Sbjct: 1066 AEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPE 1125

Query: 180  -----RDYRTGPCFGQVGPEG-CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQ----- 228
                    R   C+ Q G +G C   L G   T   CC   GR WG  C  CP +     
Sbjct: 1126 SPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH 1185

Query: 229  --------------------------------------------PHP------CRRGFIP 238
                                                        P P      C  GF  
Sbjct: 1186 CPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQL 1245

Query: 239  NIHTGACQDVDECQAVPG---LCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
            +     C D+DEC+ +     LC+   CVN  GSF C C  G   S    AC   R
Sbjct: 1246 DASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1301



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 35/118 (29%), Positives = 43/118 (36%), Gaps = 20/118 (16%)

Query: 1122 GLCPHGQCVNVIGAF--QCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRC 1179
            GL     C   IG    Q  CH           C  +    VQ  G         G    
Sbjct: 296  GLTKQEDCCGSIGTAWGQSKCHK----------CPQLQYTGVQKPG------PVRGEVGA 339

Query: 1180 SCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCV 1237
             C QGY  + +   C D++EC   P VC  G C N PG +RC+C  G    P    C+
Sbjct: 340  DCPQGYKRL-NSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 12/93 (12%)

Query: 2526 CEDVNECDGPHRCQHGCQNQLGGYR----------CSCPQGFTQHSQWAQCVDENECALS 2575
            C  +    G  +C    Q Q  G +            CPQG+ + +    C D NECA+ 
Sbjct: 304  CGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS-THCQDINECAM- 361

Query: 2576 PPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
            P  C    C N  G +RCVCP G     +   C
Sbjct: 362  PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 59/201 (29%), Positives = 71/201 (35%), Gaps = 51/201 (25%)

Query: 9   ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC 68
           A G LA LLL    LL + G  GR +G     GP   R  G  G L        RF    
Sbjct: 20  AAGLLALLLLL---LLLLLGLGGRVEG-----GPAGERGAGGGGAL-----ARERFKVVF 66

Query: 69  CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG 128
            P              IC+R C +G C               SC   +GS  ++   NG 
Sbjct: 67  AP-------------VICKRTCLKGQCRD-------------SC--QQGSNMTLIGENG- 97

Query: 129 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF 188
                  L   G+   VC  P     C NGG+C   N+C C   F G  C+     G   
Sbjct: 98  --HSTDTLTGSGFRVVVCPLP-----CMNGGQCSSRNQCLCPPDFTGRFCQ--VPAGGAG 148

Query: 189 GQVGPEGCQHQLTGLVCTKAL 209
           G  G  G     TG + T AL
Sbjct: 149 GGTGGSGPGLSRTGALSTGAL 169



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 47/189 (24%), Positives = 65/189 (34%), Gaps = 43/189 (22%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGG-GRGWGP-RCELCPLPGTSAYRKLCPHGS 2355
            G CF + L       S+    +T+ E CCG  G  WG  +C  CP    +  +K  P   
Sbjct: 277  GRCFQDTLPKQPCG-SNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP--- 332

Query: 2356 GYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKP 2415
                                        G     C  GY     +T C D++EC+ +P  
Sbjct: 333  --------------------------VRGEVGADCPQGYKR-LNSTHCQDINECA-MPGV 364

Query: 2416 CTFL-CKNTKGSFLCSCPRGYLLEEDGRTC-----KDLDEC---TSRQHNCQFLCVNTVG 2466
            C    C N  GS+ C CP G+ L      C     ++   C    S +H CQ      + 
Sbjct: 365  CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLT 424

Query: 2467 AFTCRCPPG 2475
               C C  G
Sbjct: 425  RQLCCCSVG 433



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 3/75 (4%)

Query: 1341 VPGSYRCTCRQGFAG-DGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDH 1399
            V G     C QG+   +   C+D +ECA    +C +G CLN PG YRC C  G       
Sbjct: 333  VRGEVGADCPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 1400 RACQDVDECAQGNLC 1414
              C   D+  + +LC
Sbjct: 392  TQC-IADKPEEKSLC 405



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 41/163 (25%), Positives = 61/163 (37%), Gaps = 35/163 (21%)

Query: 2059 EGSAAFQELCPFGHGAVPGPDDSR------EDV---NECAENP--GVCTNGVCVNTDGSF 2107
            E +A  Q L P    + P P   +      +D      C  NP  G+     C  + G+ 
Sbjct: 251  ESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTA 310

Query: 2108 ----RC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM 2162
                +C +CP    L +TG+         VG  C QG                ++     
Sbjct: 311  WGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQG----------------YKRLNST 351

Query: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC 2205
             C+DI+EC++  +     C N  GSY C CP G++L      C
Sbjct: 352  HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394



 Score = 37.4 bits (85), Expect = 0.21
 Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 3/47 (6%)

Query: 2595 CPSGFDFDQALGGCQEVDECAGRRGPCSYS-CANTPGGFLCGCPQGY 2640
            CP G+    +   CQ+++ECA   G C +  C N PG + C CP G+
Sbjct: 341  CPQGYKRLNSTH-CQDINECA-MPGVCRHGDCLNNPGSYRCVCPPGH 385


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  436 bits (1121), Expect = e-121
 Identities = 478/1713 (27%), Positives = 653/1713 (38%), Gaps = 359/1713 (20%)

Query: 995  GLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNT----PGS 1050
            G CT    R       C C  G+  +     C   D C   P   G+G C ++       
Sbjct: 53   GRCTQLPSREAA----CLCPPGWVGE----RCQLEDPCHSGP-CAGRGVCQSSVVAGTAR 103

Query: 1051 FECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCT-NTDGSYKCQCPPGHELTAKGT 1109
            F C C  G+        +C   D C   P    G  C+   DG + C CPPG++    G 
Sbjct: 104  FSCRCPRGFRG-----PDCSLPDPCLSSPC-AHGARCSVGPDGRFLCSCPPGYQ----GR 153

Query: 1110 ACE-DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDV 1168
            +C  D+DEC + +     G C+N  G+F+C C AG+         V       +NGG   
Sbjct: 154  SCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGT-- 211

Query: 1169 HCINT-EGSYRCSCGQGYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLC--- 1223
             C  + + +Y C+C  G+    +G+ C  +VD+C  + R  + G C +    + C C   
Sbjct: 212  -CRQSGDLTYDCACLPGF----EGQNCEVNVDDCPGH-RCLNGGTCVDGVNTYNCQCPPE 265

Query: 1224 YDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVCHCQLGYMVRKGATGCSDVD 1282
            + G   T D      VDEC L P+ C +G  C NT G   C C  G+    G +   ++D
Sbjct: 266  WTGQFCTED------VDECQLQPNACHNGGTCFNTLGGHSCVCVNGWT---GESCSQNID 316

Query: 1283 ECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVP 1342
            +C      C   A+C +   SF C C  G  G    CH  D CVS         D   V 
Sbjct: 317  DCATAV--CFHGATCHDRVASFYCACPMGKTG--LLCHLDDACVSNPCHEDAICDTNPVN 372

Query: 1343 GSYRCTCRQGFAGDGFFCEDRDECAENVDLCDN-GQCLNAPGGYRCECEMGFDPTEDHRA 1401
            G   CTC  GF G G   +D DEC+   + C++ G+C+N  G + C+C  G+      R 
Sbjct: 373  GRAICTCPPGFTG-GACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGP---RC 428

Query: 1402 CQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-TDINECADPVNCING-V 1459
              DV+EC  G      +C +  G F CIC  G+     G  C  DI+EC     C+NG V
Sbjct: 429  ETDVNECLSGPCRNQATCLDRIGQFTCICMAGFT----GTYCEVDIDECQSSP-CVNGGV 483

Query: 1460 CINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASC 1519
            C +    + C+CP  F                          SG +C  ++         
Sbjct: 484  CKDRVNGFSCTCPSGF--------------------------SGSTCQLDVDE------- 510

Query: 1520 CCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDC 1579
            C S     G  C   P      Y   C   EGF+    T+   ++D+C   P  C  G C
Sbjct: 511  CASTPCRNGAKCVDQPDG----YECRC--AEGFEG---TLCDRNVDDCS--PDPCHHGRC 559

Query: 1580 VNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQV 1639
            V+   SF C C PGY     TR    +DEC +     G G C + +  Y C CP+    V
Sbjct: 560  VDGIASFSCACAPGY---TGTRCESQVDECRSQPCRHG-GKCLDLVDKYLCRCPSGTTGV 615

Query: 1640 NGGNNCMDMRKSVC--------FRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEAC 1691
            N   N  D   + C           Y+  CQ      +      C+  I +  + PC   
Sbjct: 616  NCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPL------CNVEINECASSPCGEG 669

Query: 1692 PTPISPD--YQILC--GNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCE 1747
             + +  +  ++ LC  G+  P  L   H         C   P  C++GIC +  G FRC 
Sbjct: 670  GSCVDGENGFRCLCPPGSLPPLCLPPSHP--------CAHEP--CSHGICYDAPGGFRCV 719

Query: 1748 CPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRN 1807
            C  G++      +    D C S+  PC+    C +    + C C  G +   G  C   +
Sbjct: 720  CEPGWSGPRCSQSLAR-DACESQ--PCRAGGTCSSDGMGFHCTCPPGVQ---GRQCELLS 773

Query: 1808 ECREIPNVCSHGD-CMDTEGSY-MCLCHRGFQASADQTLCMDIDEC-DRQPCG-NGTCKN 1863
             C   PN C HG  C    G   +C C +G+Q    Q    D+DEC    PCG +G C N
Sbjct: 774  PCT--PNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ---QDVDECAGPAPCGPHGICTN 828

Query: 1864 IIGSYNCLCFPGFV-VTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTA 1922
            + GS++C C  G+   + + D  D D    L G     G C +  GSF C C  GF    
Sbjct: 829  LAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNG-----GSCQDGVGSFSCSCLPGFA--- 880

Query: 1923 DGKNCV-DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCI-DIDECSEEPNLC 1980
             G  C  D +ECLS    C PGTC +   SF C CPPG+     HC  D+ +CS  P+ C
Sbjct: 881  -GPRCARDVDECLS--NPCGPGTCTDHVASFTCTCPPGYG--GFHCEQDLPDCS--PSSC 933

Query: 1981 LFG-TCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRC 2039
              G TC +   SF CLC PG+  +   H         C      G CS          RC
Sbjct: 934  FNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCL---HGGVCSAAHP----GFRC 986

Query: 2040 CCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGV 2099
             C +      G  C+                              V+ C+  P  C NG 
Sbjct: 987  TCLE---SFTGPQCQTL----------------------------VDWCSRQP--CQNGG 1013

Query: 2100 -CVNTDGSFRCECPFGYSLDFTGINCVDTDECS--VGHPCGQ-----GTCTNVIGGFECA 2151
             CV T G++ C CP G+S     I  +   E +  +G    Q     G C +      C 
Sbjct: 1014 RCVQT-GAY-CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCV 1071

Query: 2152 CADGFEPGLMMTCE-DIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRD-VD 2209
            C +G        CE ++D C   P      C    G Y+C C  GY    +G  C D VD
Sbjct: 1072 CPEGRTGS---HCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVD 1124

Query: 2210 ECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCT-DDNECHAQPDL-----C 2263
            ECA   Q C   G  C +L+  + C CPPG       G  C  ++++C   P L     C
Sbjct: 1125 ECAS--QPCQ-HGGSCIDLVARYLCSCPPGTL-----GVLCEINEDDCGPGPPLDSGPRC 1176

Query: 2264 V-NGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRA 2322
            + NG CV+  G FRC C  G+       + ++ R G C A   +   +            
Sbjct: 1177 LHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGG------F 1230

Query: 2323 ECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINS 2382
             C C  G   GPRC+    P  S   + C HG                      G+C  S
Sbjct: 1231 RCLCHAGFS-GPRCQTVLSPCES---QPCQHG----------------------GQCRPS 1264

Query: 2383 LG-----SFRCHC-QAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYL 2436
             G     +F CHC Q  + P            C ++  P    C+ T     C+CP G  
Sbjct: 1265 PGPGGGLTFTCHCAQPFWGPRCERVA----RSCRELQCPVGVPCQQTPRGPRCACPPGL- 1319

Query: 2437 LEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPC 2496
                G +C+                           PPG +        N  C+A   PC
Sbjct: 1320 ---SGPSCRSFP----------------------GSPPGAS--------NASCAA--APC 1344

Query: 2497 GAHGHCHNTPGS--FRCECHQGFTLVSSGHGCE---DVNECDGPHRC-QHGCQNQLGGYR 2550
               G C   P +  FRC C QG+T    G  CE      E     RC +  CQ + G  R
Sbjct: 1345 LHGGSCRPAPLAPFFRCACAQGWT----GPRCEAPAAAPEVSEEPRCPRAACQAKRGDQR 1400

Query: 2551 CSCPQGFTQHSQWAQCVDENECALSP----PTCGSASCRNTLGGFRC--VCPSGF----D 2600
            C   +  +    W    D  +C+LS       C +  C       RC   C S      +
Sbjct: 1401 CD-RECNSPGCGW----DGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDN 1455

Query: 2601 FDQALGG----CQEVDE--CAGR--RGPCSYSC 2625
            FD   GG    C  V E  CA     G C   C
Sbjct: 1456 FDCHAGGRERTCNPVYEKYCADHFADGRCDQGC 1488



 Score =  431 bits (1108), Expect = e-120
 Identities = 428/1486 (28%), Positives = 588/1486 (39%), Gaps = 328/1486 (22%)

Query: 1275 ATGCSDVDECEVGGHNCDSHASCLNIPG-SFSCRCLPGWVGDGFECHDLDECVSQEHRCS 1333
            A  C D   C  GG        C  +P    +C C PGWVG+   C   D C S    C+
Sbjct: 40   APPCLDGSPCANGGR-------CTQLPSREAACLCPPGWVGE--RCQLEDPCHSGP--CA 88

Query: 1334 PRGDCLN--VPGSYR--CTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCEC 1389
             RG C +  V G+ R  C C +GF G      D               CL++P       
Sbjct: 89   GRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPD--------------PCLSSP------- 127

Query: 1390 EMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-TDINE 1448
                              CA G  C+ G      G F C C  GY+    G +C +D++E
Sbjct: 128  ------------------CAHGARCSVGP----DGRFLCSCPPGYQ----GRSCRSDVDE 161

Query: 1449 CADPVNCING-VCINTPGSYLCSCPQDFE----LNPSGVGCVDT---RAGNCFLETHDRG 1500
            C     C +G  C+NTPGS+ C CP  +      NP+ V C  +     G C       G
Sbjct: 162  CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPA-VPCAPSPCRNGGTC----RQSG 216

Query: 1501 DSGISCSAEIGVGVTRASCCCSLGRAWGNPC---ELCPMANTTEYRTLCPGGEGFQPNRI 1557
            D    C+     G    +C  ++    G+ C     C +     Y   CP     Q    
Sbjct: 217  DLTYDCACL--PGFEGQNCEVNVDDCPGHRCLNGGTC-VDGVNTYNCQCPPEWTGQ---- 269

Query: 1558 TVILEDIDECQELPGLCQ-GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGIC 1616
                ED+DECQ  P  C  GG C NT G   C C  G+         ++ID+C+T   +C
Sbjct: 270  -FCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW---TGESCSQNIDDCAT--AVC 323

Query: 1617 GPG-TCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR---HYNGTCQNELAFNVTRK 1672
              G TC++ + ++ C CP       G    +      C     H +  C         R 
Sbjct: 324  FHGATCHDRVASFYCACPM------GKTGLLCHLDDACVSNPCHEDAICDTNPVNG--RA 375

Query: 1673 MCCCSYNI-GQAWNR----------PCEACPTPISPDYQILC----GNQAPGFLTDIH-- 1715
            +C C     G A ++          PCE     ++     LC    G   P   TD++  
Sbjct: 376  ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNEC 435

Query: 1716 ----------------------------TGKPLDIDECGEIPAICANG-ICINQIGSFRC 1746
                                        T   +DIDEC   P  C NG +C +++  F C
Sbjct: 436  LSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSP--CVNGGVCKDRVNGFSC 493

Query: 1747 ECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGR 1806
             CP+GF+ ++  L   DVDEC S  +PC+  A C++ P  Y C+C  G++    G    R
Sbjct: 494  TCPSGFSGSTCQL---DVDECAS--TPCRNGAKCVDQPDGYECRCAEGFE----GTLCDR 544

Query: 1807 NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNG-TCKNII 1865
            N     P+ C HG C+D   S+ C C  G+  +  ++    +DEC  QPC +G  C +++
Sbjct: 545  NVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCES---QVDECRSQPCRHGGKCLDLV 601

Query: 1866 GSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
              Y C C  G   T   +C V+ D+C +     C FG C +    + C+CQ GF     G
Sbjct: 602  DKYLCRCPSG---TTGVNCEVNIDDCAS---NPCTFGVCRDGINRYDCVCQPGFT----G 651

Query: 1925 KNC-VDTNECLSL----AGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDE-CSEEPN 1978
              C V+ NEC S      G+C+ G     E  FRC+CPPG       C+     C+ EP 
Sbjct: 652  PLCNVEINECASSPCGEGGSCVDG-----ENGFRCLCPPGSLPPL--CLPPSHPCAHEP- 703

Query: 1979 LCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTR 2038
             C  G C ++PG F+C+C PG+    +G RC                       + +  R
Sbjct: 704  -CSHGICYDAPGGFRCVCEPGW----SGPRC-----------------------SQSLAR 735

Query: 2039 CCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSR-EDVNECAENPGVCTN 2097
              C  +P    G     C  +G   F   CP      PG    + E ++ C  NP  C +
Sbjct: 736  DACESQPCRAGGT----CSSDGMG-FHCTCP------PGVQGRQCELLSPCTPNP--CEH 782

Query: 2098 GV-CVNTDGSFR-CECPFGYSLDFTGINCV-DTDECSVGHPCG-QGTCTNVIGGFECACA 2153
            G  C +  G    C CP G+     G  C  D DEC+   PCG  G CTN+ G F C C 
Sbjct: 783  GGRCESAPGQLPVCSCPQGWQ----GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCH 838

Query: 2154 DGFEPGLMMTCE-DIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC-RDVDEC 2211
             G+      +C+ DI++C  NP L    C +  GS+ C+C  G+     G  C RDVDEC
Sbjct: 839  GGYTGP---SCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFA----GPRCARDVDEC 891

Query: 2212 ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQPDLCVNG-RCV 2269
                         C + + +F C CPPG       G  C  D  +C   P  C NG  CV
Sbjct: 892  LSNP----CGPGTCTDHVASFTCTCPPGY-----GGFHCEQDLPDC--SPSSCFNGGTCV 940

Query: 2270 NTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVL--------QTMCRSLSSSSEAVTR 2321
            +   SF C C  G+  +    E       PC    +        +  C    +  +  T 
Sbjct: 941  DGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTL 1000

Query: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPHG-SGYTAEGRDVDECR--------MLAH 2372
             + C       G RC       T AY  LCP G SG   + R +  CR         L  
Sbjct: 1001 VDWCSRQPCQNGGRCVQ-----TGAYC-LCPPGWSGRLCDIRSLP-CREAAAQIGVRLEQ 1053

Query: 2373 LC-AHGECINSLGSFRCHCQAGYTPDATATTC-LDMDECSQVPKPCTFLCKNTKGSFLCS 2430
            LC A G+C++   S  C C  G     T + C  ++D C   P      C+   G ++C 
Sbjct: 1054 LCQAGGQCVDEDSSHYCVCPEG----RTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCE 1109

Query: 2431 CPRGYLLEEDGRTCKD-LDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDEC 2489
            C  GY    +G  C+D +DEC S+       C++ V  + C CPPG T       + D+C
Sbjct: 1110 CLPGY----NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPG-TLGVLCEINEDDC 1164

Query: 2490 SAQP----GP-CGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNEC-DGPHRCQHG- 2541
               P    GP C  +G C +  G FRC C  G+T    G  CE D+NEC  G     H  
Sbjct: 1165 GPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYT----GLRCEADINECRSGACHAAHTR 1220

Query: 2542 --CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGG-----FRCV 2594
               Q+  GG+RC C  GF+      +C        S P      CR + G      F C 
Sbjct: 1221 DCLQDPGGGFRCLCHAGFSG----PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCH 1276

Query: 2595 CPSGFDFDQALGGCQEVDE-CAGRRGPCSYSCANTPGGFLCGCPQG 2639
            C   F   +    C+ V   C   + P    C  TP G  C CP G
Sbjct: 1277 CAQPFWGPR----CERVARSCRELQCPVGVPCQQTPRGPRCACPPG 1318



 Score =  425 bits (1093), Expect = e-118
 Identities = 476/1610 (29%), Positives = 625/1610 (38%), Gaps = 307/1610 (19%)

Query: 100  LCTCADGTLAPSCGVSRGSGCSVSCMNGGTC-----RGASCLCQKGYTGTVC-------G 147
            L     G  AP C    GS C+    NGG C     R A+CLC  G+ G  C        
Sbjct: 31   LLLAGPGAAAPPC--LDGSPCA----NGGRCTQLPSREAACLCPPGWVGERCQLEDPCHS 84

Query: 148  QPICDRGCHNGGRCIGPNR--CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVC 205
             P   RG        G  R  C C  GF GP C       PC        C H   G  C
Sbjct: 85   GPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP---DPCLSSP----CAH---GARC 134

Query: 206  TKALCCATVGRAWGLPCELCPA-QPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCV 264
            +       VG      C   P  Q   CR             DVDEC+       GG+C+
Sbjct: 135  S-------VGPDGRFLCSCPPGYQGRSCR------------SDVDECRVGEPCRHGGTCL 175

Query: 265  NMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRC 324
            N  GSF C+CP G+    +   CE+       S                    C + G C
Sbjct: 176  NTPGSFRCQCPAGY----TGPLCENPAVPCAPSP-------------------CRNGGTC 212

Query: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG---PP------- 374
              +G +   C      E Q  C   +   PGH  L  G    G N      PP       
Sbjct: 213  RQSGDLTYDCACLPGFEGQN-CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC 271

Query: 375  ---LGPARLNPHGSDARG--IPSLGPGNSNIGT-----ATLNQTIDICRHFTNLCLNG-R 423
               +   +L P+     G    +LG G+S +        + +Q ID C   T +C +G  
Sbjct: 272  TEDVDECQLQPNACHNGGTCFNTLG-GHSCVCVNGWTGESCSQNIDDCA--TAVCFHGAT 328

Query: 424  CLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHG---DCVNIPGTYHCRCYPGFQA 480
            C    +S+ C C +G T  +   C   D C S+PCH     D   + G   C C PGF  
Sbjct: 329  CHDRVASFYCACPMGKTGLL---CHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGF-- 383

Query: 481  TPTRQAC-VDVDECIVSGGLC-HLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECAT 537
              T  AC  DVDEC +    C HLGRCVNT+GSF C C  G+     G  C  D NEC +
Sbjct: 384  --TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNECLS 437

Query: 538  STMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC-MDIDECQTPGICVNGH-CTNTEGSFR 595
                    CL+  G F+C+C  GF     G YC +DIDECQ+   CVNG  C +    F 
Sbjct: 438  GPCRNQATCLDRIGQFTCICMAGFT----GTYCEVDIDECQS-SPCVNGGVCKDRVNGFS 492

Query: 596  CQCLGGLAVGTDGRVCVDTHVRSTCYGAIE--------KGSCARPFPGTVTKSECCCANP 647
            C C  G + G+  ++ VD    + C    +        +  CA  F GT+     C  N 
Sbjct: 493  CTCPSGFS-GSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTL-----CDRNV 546

Query: 648  DHGFGEPCQLCPAKDS-AEFQALCSSGLGITTDGRDINECALDPEVCAN-GVCENLRGSY 705
            D    +PC      D  A F   C+ G   T     ++EC   P  C + G C +L   Y
Sbjct: 547  DDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQP--CRHGGKCLDLVDKY 604

Query: 706  RCVCNLGYEAGASGKDC-TDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEIC 764
             C C     +G +G +C  ++D+CA N   C  G C++    Y C C PGF       +C
Sbjct: 605  LCRC----PSGTTGVNCEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGF----TGPLC 654

Query: 765  K-DVDECLSSPC-VSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822
              +++EC SSPC   G C +    + C C PGS L P    CL  +            C 
Sbjct: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPGS-LPP---LCLPPSH-----PCAHEPCS 705

Query: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPN 882
              +         C      +   CE     P C++  AR         + CES P     
Sbjct: 706  HGI---------CYDAPGGFRCVCEPGWSGPRCSQSLAR---------DACESQP-CRAG 746

Query: 883  GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDE--DECGVTLPGKYRMDVCC 940
            G C +    F C CP G+     GR C    L PC     E    C  + PG  ++ VC 
Sbjct: 747  GTCSSDGMGFHCTCPPGV----QGRQC--ELLSPCTPNPCEHGGRC-ESAPG--QLPVCS 797

Query: 941  CSIGAVW-GVEC----EACPDPESLEFASLCPRGLGFAS---RDFLSGRPFYKDVNECKV 992
            C  G  W G  C    + C  P       +C    G  S       +G    +D+N+C  
Sbjct: 798  CPQG--WQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDP 855

Query: 993  FPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFE 1052
             P L   G+C++ VGSF C+C  GF   A  R   D+DEC  +P  CG GTC +   SF 
Sbjct: 856  NPCL-NGGSCQDGVGSFSCSCLPGF---AGPRCARDVDECLSNP--CGPGTCTDHVASFT 909

Query: 1053 CECFPGYESGFMLMKNC-MDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTA 1110
            C C PGY  GF    +C  D+ +C+  P  C  GGTC +   S+ C C PG+     G  
Sbjct: 910  CTCPPGY-GGF----HCEQDLPDCS--PSSCFNGGTCVDGVNSFSCLCRPGY----TGAH 958

Query: 1111 CEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVD-INECRVQNGGCDVH 1169
            C+   +  LS      G C      F+C+C   F + P  Q  VD  +    QNGG    
Sbjct: 959  CQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESF-TGPQCQTLVDWCSRQPCQNGG---R 1014

Query: 1170 CINTEGSYRCSCGQGYSLMPDGRACADVDE--CEEN--------PRVCDQ-GHCTNMPGG 1218
            C+ T G+Y C C  G+S    GR C D+    C E          ++C   G C +    
Sbjct: 1015 CVQT-GAY-CLCPPGWS----GRLC-DIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSS 1067

Query: 1219 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLH-GDCENTKGSFVCHCQLGYMVRKGATG 1277
            H C+C +G   +   +   +VD C   P  C H G C    G ++C C  GY    G   
Sbjct: 1068 HYCVCPEGRTGSHCEQ---EVDPCLAQP--CQHGGTCRGYMGGYMCECLPGY---NGDNC 1119

Query: 1278 CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDEC-----VSQEHRC 1332
              DVDEC      C    SC+++   + C C PG +G   E ++ D+C     +    RC
Sbjct: 1120 EDDVDEC--ASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINE-DDCGPGPPLDSGPRC 1176

Query: 1333 SPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAENV-DLCDNGQCLNAP-GGYRCEC 1389
               G C+++ G +RCTC  G+   G  CE D +EC            CL  P GG+RC C
Sbjct: 1177 LHNGTCVDLVGGFRCTCPPGYT--GLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLC 1234

Query: 1390 EMGFDPTEDHRACQDVDECAQGNLCAF-GSCENLPG-----MFRCICNGGYELDRGGGNC 1443
              GF        CQ V    +   C   G C   PG      F C C   +     G  C
Sbjct: 1235 HAGFSGPR----CQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPF----WGPRC 1286

Query: 1444 TDINECADPVNCINGV-CINTPGSYLCSCP--------QDFELNPSGVGCVDTRAGNCFL 1494
              +      + C  GV C  TP    C+CP        + F  +P G       A  C  
Sbjct: 1287 ERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCL- 1345

Query: 1495 ETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNP-CELCPMANTTEYRTLCPGGEGFQ 1553
                    G SC         R  C C+ G  W  P CE    A        CP     Q
Sbjct: 1346 -------HGGSCRPAPLAPFFR--CACAQG--WTGPRCEAPAAAPEVSEEPRCPRA-ACQ 1393

Query: 1554 PNRITVILEDIDECQELPGLCQGGDCVNTFGS--FQCECPPGYHLSEHTR 1601
              R     +   EC        GGDC  + G    QCE    + L  ++R
Sbjct: 1394 AKRGDQRCD--RECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSR 1441



 Score =  422 bits (1086), Expect = e-117
 Identities = 445/1571 (28%), Positives = 606/1571 (38%), Gaps = 362/1571 (23%)

Query: 951  CEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGS-- 1008
            C++     +  F+  CPRG  F   D     P       C   P  C HG  R +VG   
Sbjct: 93   CQSSVVAGTARFSCRCPRG--FRGPDCSLPDP-------CLSSP--CAHGA-RCSVGPDG 140

Query: 1009 -FHCACAGGFALDAQERNC-TDIDECRISPDLCGQGTCVNTPGSFECECFPGY------- 1059
             F C+C  G+    Q R+C +D+DECR+       GTC+NTPGSF C+C  GY       
Sbjct: 141  RFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCEN 196

Query: 1060 -----------------ESGFMLM----------KNC-MDVDECARDPLLCRGGTCTNTD 1091
                             +SG +            +NC ++VD+C     L  GGTC +  
Sbjct: 197  PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCL-NGGTCVDGV 255

Query: 1092 GSYKCQCPPGHELTAKGTAC-EDIDECSLSDGLCPH-GQCVNVIGAFQCSCHAGFQSTPD 1149
             +Y CQCPP  E T  G  C ED+DEC L    C + G C N +G   C C  G+     
Sbjct: 256  NTYNCQCPP--EWT--GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESC 311

Query: 1150 RQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP----R 1205
             Q   +I++C          C +   S+ C+C  G +    G  C   D C  NP     
Sbjct: 312  SQ---NIDDCATAVCFHGATCHDRVASFYCACPMGKT----GLLCHLDDACVSNPCHEDA 364

Query: 1206 VCDQGHCTNMPGGHR-CLCYDGFMATPDMRTC-VDVDECDLNPHICLH-GDCENTKGSFV 1262
            +CD    TN   G   C C  GF        C  DVDEC +  + C H G C NT+GSF+
Sbjct: 365  ICD----TNPVNGRAICTCPPGFTG----GACDQDVDECSIGANPCEHLGRCVNTQGSFL 416

Query: 1263 CHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDL 1322
            C C  GY    G    +DV+EC  G   C + A+CL+  G F+C C+ G+ G   E  D+
Sbjct: 417  CQCGRGY---TGPRCETDVNECLSG--PCRNQATCLDRIGQFTCICMAGFTGTYCEV-DI 470

Query: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAENVDLCDNG-QCLN 1380
            DEC  Q   C   G C +    + CTC  GF+G    C+ D DECA     C NG +C++
Sbjct: 471  DEC--QSSPCVNGGVCKDRVNGFSCTCPSGFSGS--TCQLDVDECASTP--CRNGAKCVD 524

Query: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1440
             P GY C C  GF+ T   R   +VD+C+  + C  G C +    F C C  GY     G
Sbjct: 525  QPDGYECRCAEGFEGTLCDR---NVDDCSP-DPCHHGRCVDGIASFSCACAPGYT----G 576

Query: 1441 GNC-TDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDR 1499
              C + ++EC        G C++    YLC CP                           
Sbjct: 577  TRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPS-------------------------- 610

Query: 1500 GDSGISCSAEIGVGVTRASCCCSLGRAWGNPCE--LCPMANTTEYRTLC-PGGEGFQPNR 1556
            G +G++C   I         C S      NPC   +C       Y  +C PG  G   N 
Sbjct: 611  GTTGVNCEVNI-------DDCAS------NPCTFGVC-RDGINRYDCVCQPGFTGPLCN- 655

Query: 1557 ITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGIC 1616
                  +I+EC   P   +GG CV+    F+C CPPG        +C        H   C
Sbjct: 656  -----VEINECASSP-CGEGGSCVDGENGFRCLCPPG----SLPPLCLPPSHPCAHEP-C 704

Query: 1617 GPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR---HYNGTCQNE-LAFNVTRK 1672
              G CY+  G + CVC   +   +G      + +  C        GTC ++ + F+    
Sbjct: 705  SHGICYDAPGGFRCVCEPGW---SGPRCSQSLARDACESQPCRAGGTCSSDGMGFH---- 757

Query: 1673 MCCCSYNIGQAWNRPCEACP--TPISPDYQILCGNQAPGFLTDIHTGK-------PLDID 1723
             C C   +     R CE     TP   ++   C   APG L      +         D+D
Sbjct: 758  -CTCPPGV---QGRQCELLSPCTPNPCEHGGRC-ESAPGQLPVCSCPQGWQGPRCQQDVD 812

Query: 1724 ECGEIPAICA-NGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCIN 1782
            EC   PA C  +GIC N  GSF C C  G+   S     +D+++C    +PC     C +
Sbjct: 813  ECAG-PAPCGPHGICTNLAGSFSCTCHGGYTGPS---CDQDINDCD--PNPCLNGGSCQD 866

Query: 1783 IPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQ 1842
              GS+ C C  G+     G    R+    + N C  G C D   S+ C C  G+     +
Sbjct: 867  GVGSFSCSCLPGF----AGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCE 922

Query: 1843 TLCMDIDECDRQPCGN-GTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTT---LVGQVC 1898
                D+ +C    C N GTC + + S++CLC PG+   H     + D C +   L G VC
Sbjct: 923  ---QDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQH--EADPCLSRPCLHGGVC 977

Query: 1899 RFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQN----LEGSFRC 1954
               H       F C C + F             +C +L   C    CQN    ++    C
Sbjct: 978  SAAH-----PGFRCTCLESF----------TGPQCQTLVDWCSRQPCQNGGRCVQTGAYC 1022

Query: 1955 ICPPGFQVQSDHCIDIDE--CSEE--------PNLC-LFGTCTNSPGSFQCLCPPGFVLS 2003
            +CPPG+   S    DI    C E           LC   G C +   S  C+CP G    
Sbjct: 1023 LCPPGW---SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG---- 1075

Query: 2004 DNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAA 2063
                                            +T   C +        PC    Q G   
Sbjct: 1076 --------------------------------RTGSHCEQEVDPCLAQPC----QHGGTC 1099

Query: 2064 FQELCPFGHGAVPG--PDDSREDVNECAENPGVCTN-GVCVNTDGSFRCECPFGYSLDFT 2120
               +  +    +PG   D+  +DV+ECA  P  C + G C++    + C CP G      
Sbjct: 1100 RGYMGGYMCECLPGYNGDNCEDDVDECASQP--CQHGGSCIDLVARYLCSCPPG----TL 1153

Query: 2121 GINC-VDTDECSVGHPCG-------QGTCTNVIGGFECACADGFEPGLMMTCE-DIDECS 2171
            G+ C ++ D+C  G P          GTC +++GGF C C  G+     + CE DI+EC 
Sbjct: 1154 GVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG---LRCEADINECR 1210

Query: 2172 LNPLLCAFR---CHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNL 2228
                  A       +  G + C C AG++    G  C+ V    + Q   H  G +C   
Sbjct: 1211 SGACHAAHTRDCLQDPGGGFRCLCHAGFS----GPRCQTVLSPCESQPCQH--GGQC--- 1261

Query: 2229 IGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFR-CDCDEGFQPSP 2287
                        RP PG G G T    C AQP      RC   A S R   C       P
Sbjct: 1262 ------------RPSPGPGGGLTFTCHC-AQP--FWGPRCERVARSCRELQC-------P 1299

Query: 2288 TLTECHDIRQGP---CFAEVLQTMCRSLSSSSEAVTRAEC----CCGGG----------- 2329
                C    +GP   C   +    CRS   S    + A C    C  GG           
Sbjct: 1300 VGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFF 1359

Query: 2330 -----RGW-GPRCELCPLPGTSAYRKLCPHGSGYTAEG--RDVDECRMLAHLCAHGECIN 2381
                 +GW GPRCE        +    CP  +     G  R   EC         G+C  
Sbjct: 1360 RCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSL 1419

Query: 2382 SLGSFRCHCQA 2392
            S+G     C+A
Sbjct: 1420 SVGDPWRQCEA 1430



 Score =  413 bits (1062), Expect = e-114
 Identities = 454/1593 (28%), Positives = 609/1593 (38%), Gaps = 325/1593 (20%)

Query: 447  CIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRC- 505
            C +   CT  P     C+  PG    RC               +++   SG     G C 
Sbjct: 49   CANGGRCTQLPSREAACLCPPGWVGERC--------------QLEDPCHSGPCAGRGVCQ 94

Query: 506  ---VNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGV--CLNEDGSFSCLCKPG 560
               V     F C C  GF     G +C   + C +S  C +G    +  DG F C C PG
Sbjct: 95   SSVVAGTARFSCRCPRGFR----GPDCSLPDPCLSSP-CAHGARCSVGPDGRFLCSCPPG 149

Query: 561  FLLAPGGHYC-MDIDECQTPGICVN-GHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS 618
            +     G  C  D+DEC+    C + G C NT GSFRCQC      G  G +C +  V  
Sbjct: 150  Y----QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQC----PAGYTGPLCENPAVPC 201

Query: 619  TCYGAIEKGSCARPFPGTVTKSECCCANPDHGF-GEPCQL----CPAKDSAEFQALCSSG 673
                    G+C +   G +T  +C C     GF G+ C++    CP          C +G
Sbjct: 202  APSPCRNGGTCRQ--SGDLT-YDCACL---PGFEGQNCEVNVDDCPGH-------RCLNG 248

Query: 674  LGITTDG------------------RDINECALDPEVCAN-GVCENLRGSYRCVCNLGYE 714
             G   DG                   D++EC L P  C N G C N  G + CVC  G+ 
Sbjct: 249  -GTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW- 306

Query: 715  AGASGKDCT-DVDECALNSLLCDNG-WCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLS 772
               +G+ C+ ++D+CA  + +C +G  C +   S+ C+CP G    +   +C   D C+S
Sbjct: 307  ---TGESCSQNIDDCA--TAVCFHGATCHDRVASFYCACPMG----KTGLLCHLDDACVS 357

Query: 773  SPC-VSGVC--RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGAS 829
            +PC    +C    + G   C C PG             T G C   + E  C +      
Sbjct: 358  NPCHEDAICDTNPVNGRAICTCPPG------------FTGGACDQDVDE--CSIGANPCE 403

Query: 830  LRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNECESFPGVCPN-GRCVN 887
                C  T G+     C+       C RG+   TG  C+ DVNEC S  G C N   C++
Sbjct: 404  HLGRCVNTQGSFL---CQ-------CGRGY---TGPRCETDVNECLS--GPCRNQATCLD 448

Query: 888  TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVW 947
              G F C C  G     +G  C            D DEC              C  G V 
Sbjct: 449  RIGQFTCICMAGF----TGTYC----------EVDIDEC----------QSSPCVNGGV- 483

Query: 948  GVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT-CRNTV 1006
                  C D  +  F+  CP G         SG     DV+EC   P  C +G  C +  
Sbjct: 484  ------CKDRVN-GFSCTCPSG--------FSGSTCQLDVDECASTP--CRNGAKCVDQP 526

Query: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM 1066
              + C CA GF     +RN   +D+C  SPD C  G CV+   SF C C PGY       
Sbjct: 527  DGYECRCAEGFEGTLCDRN---VDDC--SPDPCHHGRCVDGIASFSCACAPGYTG----- 576

Query: 1067 KNC-MDVDECARDPLLCR-GGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECSLSDGL 1123
              C   VDEC   P  CR GG C +    Y C+CP G      G  CE +ID+C+ +   
Sbjct: 577  TRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSG----TTGVNCEVNIDDCASNP-- 628

Query: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQ 1183
            C  G C + I  + C C  GF         V+INEC     G    C++ E  +RC C  
Sbjct: 629  CTFGVCRDGINRYDCVCQPGFTGPLCN---VEINECASSPCGEGGSCVDGENGFRCLCPP 685

Query: 1184 GYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECD 1243
            G SL P          C   P  C  G C + PGG RC+C  G+ + P     +  D C+
Sbjct: 686  G-SLPP--LCLPPSHPCAHEP--CSHGICYDAPGGFRCVCEPGW-SGPRCSQSLARDACE 739

Query: 1244 LNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGS 1303
              P     G C +    F C C  G   R+    C  +  C    + C+    C + PG 
Sbjct: 740  SQP-CRAGGTCSSDGMGFHCTCPPGVQGRQ----CELLSPCT--PNPCEHGGRCESAPGQ 792

Query: 1304 FS-CRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC-E 1361
               C C  GW G   +  D+DEC      C P G C N+ GS+ CTC  G+ G    C +
Sbjct: 793  LPVCSCPQGWQGPRCQ-QDVDECAGPA-PCGPHGICTNLAGSFSCTCHGGYTGPS--CDQ 848

Query: 1362 DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCEN 1421
            D ++C  N  L + G C +  G + C C  GF      R  +DVDEC   N C  G+C +
Sbjct: 849  DINDCDPNPCL-NGGSCQDGVGSFSCSCLPGF---AGPRCARDVDECL-SNPCGPGTCTD 903

Query: 1422 LPGMFRCICNGGYELDRGGGNC-TDINECADPVNCIN-GVCINTPGSYLCSCPQDFELNP 1479
                F C C  GY    GG +C  D+ +C+ P +C N G C++   S+ C C   +    
Sbjct: 904  HVASFTCTCPPGY----GGFHCEQDLPDCS-PSSCFNGGTCVDGVNSFSCLCRPGY---- 954

Query: 1480 SGVGCVDTRAGNCFLETHDRGDSGISCSAEIGV------GVTRASCCCSLGRAWGNPCEL 1533
            +G  C    A  C       G  G+  +A  G         T   C   +      PC+ 
Sbjct: 955  TGAHC-QHEADPCLSRPCLHG--GVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQN 1011

Query: 1534 CPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQE--------LPGLCQ-GGDCVNTFG 1584
                  T    LCP G   +   I  +      C+E        L  LCQ GG CV+   
Sbjct: 1012 GGRCVQTGAYCLCPPGWSGRLCDIRSL-----PCREAAAQIGVRLEQLCQAGGQCVDEDS 1066

Query: 1585 SFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644
            S  C CP G     H    +++D C       G GTC   +G Y C C   Y     G+N
Sbjct: 1067 SHYCVCPEG-RTGSHCE--QEVDPCLAQPCQHG-GTCRGYMGGYMCECLPGY----NGDN 1118

Query: 1645 CMDMRKSVCFR--HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQIL 1702
            C D       +   + G+C + +A    R +C C               P  +     +L
Sbjct: 1119 CEDDVDECASQPCQHGGSCIDLVA----RYLCSCP--------------PGTLG----VL 1156

Query: 1703 CGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACE 1762
            C         D   G PLD       P    NG C++ +G FRC CP G+      L CE
Sbjct: 1157 CEINE----DDCGPGPPLDSG-----PRCLHNGTCVDLVGGFRCTCPPGYTG----LRCE 1203

Query: 1763 -DVDECGSRESPCQQNADCINIP-GSYRCKCTRGYKLSPGGAC-VGRNECREIPNVCSH- 1818
             D++EC S         DC+  P G +RC C  G+    G  C    + C   P  C H 
Sbjct: 1204 ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS---GPRCQTVLSPCESQP--CQHG 1258

Query: 1819 GDCMDTEG-----SYMCLCHRGFQASADQTLCMDIDE--------CDRQPCG-NGTCKNI 1864
            G C  + G     ++ C C + F     + +     E        C + P G    C   
Sbjct: 1259 GQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPG 1318

Query: 1865 IGSYNCLCFPGFVV-THNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTAD 1923
            +   +C  FPG      N  C        L G  CR       A  F C C  G+     
Sbjct: 1319 LSGPSCRSFPGSPPGASNASCA---AAPCLHGGSCR---PAPLAPFFRCACAQGW----T 1368

Query: 1924 GKNCVDTNEC--LSLAGTCLPGTCQNLEGSFRC 1954
            G  C        +S    C    CQ   G  RC
Sbjct: 1369 GPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRC 1401



 Score =  397 bits (1021), Expect = e-110
 Identities = 403/1378 (29%), Positives = 549/1378 (39%), Gaps = 285/1378 (20%)

Query: 1366 CAENVDLCDNGQCLNAPGGYR-CECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENL-- 1422
            C +     + G+C   P     C C  G+        CQ  D C  G     G C++   
Sbjct: 43   CLDGSPCANGGRCTQLPSREAACLCPPGWVGER----CQLEDPCHSGPCAGRGVCQSSVV 98

Query: 1423 --PGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVC-------INTPGSYLCSCPQ 1473
                 F C C  G+   RG        +C+ P  C++  C       +   G +LCSCP 
Sbjct: 99   AGTARFSCRCPRGF---RGP-------DCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPP 148

Query: 1474 DFE-------LNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRA 1526
             ++       ++   VG      G C    +  G     C A    G T   C       
Sbjct: 149  GYQGRSCRSDVDECRVGEPCRHGGTCL---NTPGSFRCQCPA----GYTGPLCENPAVPC 201

Query: 1527 WGNPCE---LCPMANTTEYRTLC-PGGEGFQPNRITVILEDIDECQELPG--LCQGGDCV 1580
              +PC     C  +    Y   C PG EG           ++D+C   PG     GG CV
Sbjct: 202  APSPCRNGGTCRQSGDLTYDCACLPGFEGQNCE------VNVDDC---PGHRCLNGGTCV 252

Query: 1581 NTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGIC-GPGTCYNTLGNYTCVCPAEYLQV 1639
            +   ++ C+CPP +     T   ED+DEC      C   GTC+NTLG ++CVC   +   
Sbjct: 253  DGVNTYNCQCPPEWTGQFCT---EDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGE 309

Query: 1640 NGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSY-------NIGQAW-NRPCEA- 1690
            +   N  D   +VCF  +  TC + +A       C C         ++  A  + PC   
Sbjct: 310  SCSQNIDDCATAVCF--HGATCHDRVA----SFYCACPMGKTGLLCHLDDACVSNPCHED 363

Query: 1691 --CPT-PISPDYQILCGNQAPGFLTDIHTGKPLD--IDECGEIPAICAN-GICINQIGSF 1744
              C T P++      C    PGF     TG   D  +DEC      C + G C+N  GSF
Sbjct: 364  AICDTNPVNGRAICTC---PPGF-----TGGACDQDVDECSIGANPCEHLGRCVNTQGSF 415

Query: 1745 RCECPAGFNYNSILLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC 1803
             C+C  G+        CE DV+EC S   PC+  A C++  G + C C  G+    G  C
Sbjct: 416  LCQCGRGYTGPR----CETDVNECLS--GPCRNQATCLDRIGQFTCICMAGFT---GTYC 466

Query: 1804 -VGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT-C 1861
             V  +EC+  P V + G C D    + C C  GF  S  Q   +D+DEC   PC NG  C
Sbjct: 467  EVDIDECQSSPCV-NGGVCKDRVNGFSCTCPSGFSGSTCQ---LDVDECASTPCRNGAKC 522

Query: 1862 KNIIGSYNCLCFPGFVVTHNGDCVD--FDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFE 1919
             +    Y C C  GF     G   D   D+C+      C  G C++   SF C C  G+ 
Sbjct: 523  VDQPDGYECRCAEGF----EGTLCDRNVDDCSP---DPCHHGRCVDGIASFSCACAPGYT 575

Query: 1920 LTADGKNCVD-TNECLSLAGTCLPG-TCQNLEGSFRCICPPGFQVQSDHC-IDIDECSEE 1976
                G  C    +EC S    C  G  C +L   + C CP G      +C ++ID+C+  
Sbjct: 576  ----GTRCESQVDECRSQP--CRHGGKCLDLVDKYLCRCPSG--TTGVNCEVNIDDCASN 627

Query: 1977 PNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTK 2036
            P  C FG C +    + C+C PGF     G  C                          +
Sbjct: 628  P--CTFGVCRDGINRYDCVCQPGFT----GPLC------------------------NVE 657

Query: 2037 TRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPG--PDDSREDVNECAENPGV 2094
               C S   GEG       C  +G   F+ LCP      PG  P       + CA  P  
Sbjct: 658  INECASSPCGEGGS-----CV-DGENGFRCLCP------PGSLPPLCLPPSHPCAHEP-- 703

Query: 2095 CTNGVCVNTDGSFRCECPFGYSLDFTGINCVDT---DECSVGHPC-GQGTCTNVIGGFEC 2150
            C++G+C +  G FRC C  G+S    G  C  +   D C    PC   GTC++   GF C
Sbjct: 704  CSHGICYDAPGGFRCVCEPGWS----GPRCSQSLARDACE-SQPCRAGGTCSSDGMGFHC 758

Query: 2151 ACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSY-LCTCPAGYTLREDGAMCR-DV 2208
             C  G +      CE +  C+ NP     RC +  G   +C+CP G+     G  C+ DV
Sbjct: 759  TCPPGVQG---RQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGW----QGPRCQQDV 811

Query: 2209 DECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQPDLCVNG- 2266
            DECA G   C   G+ C NL G+F+C C  G      +G  C  D N+C   P  C+NG 
Sbjct: 812  DECA-GPAPCGPHGI-CTNLAGSFSCTCHGGY-----TGPSCDQDINDCDPNP--CLNGG 862

Query: 2267 RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCC 2326
             C +  GSF C C  GF       +  +    PC             + ++ V    C C
Sbjct: 863  SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC----------GPGTCTDHVASFTCTC 912

Query: 2327 GGGRGWGPRCELCPLP---------------GTSAYRKLCPHGSGYTAEGRDVDECRMLA 2371
              G G G  CE   LP               G +++  LC  G        + D C  L+
Sbjct: 913  PPGYG-GFHCEQ-DLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC--LS 968

Query: 2372 HLCAHGE-CINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCS 2430
              C HG  C  +   FRC C   +T     T    +D CS+ P      C  T G++ C 
Sbjct: 969  RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTL---VDWCSRQPCQNGGRCVQT-GAY-CL 1023

Query: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQF------------LCVNTVGAFTCRCPPGFTQ 2478
            CP G+     GR C D+     R+   Q              CV+   +  C CP G T 
Sbjct: 1024 CPPGW----SGRLC-DIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTG 1078

Query: 2479 HHQACFDN-DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCED-VNECDGPH 2536
             H  C    D C AQP  C   G C    G + CEC  G+    +G  CED V+EC    
Sbjct: 1079 SH--CEQEVDPCLAQP--CQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDEC-ASQ 1129

Query: 2537 RCQHG--CQNQLGGYRCSCPQGFTQHSQWAQC-VDENECALSPPTCG------SASCRNT 2587
             CQHG  C + +  Y CSCP G    +    C ++E++C   PP         + +C + 
Sbjct: 1130 PCQHGGSCIDLVARYLCSCPPG----TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDL 1185

Query: 2588 LGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPC----SYSCANTP-GGFLCGCPQGY 2640
            +GGFRC CP G+     L    +++EC  R G C    +  C   P GGF C C  G+
Sbjct: 1186 VGGFRCTCPPGY---TGLRCEADINEC--RSGACHAAHTRDCLQDPGGGFRCLCHAGF 1238



 Score =  396 bits (1017), Expect = e-109
 Identities = 461/1636 (28%), Positives = 633/1636 (38%), Gaps = 344/1636 (21%)

Query: 716  GASGKDCTDVDECALNSLLCDNGWCQNSPG-SYSCSCPPGFHFWQDTEICKDVDECLSSP 774
            GA+   C D   CA      + G C   P    +C CPPG   W   E C+  D C S P
Sbjct: 37   GAAAPPCLDGSPCA------NGGRCTQLPSREAACLCPPG---WVG-ERCQLEDPCHSGP 86

Query: 775  CVS-GVCRN--LAGS--YTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGAS 829
            C   GVC++  +AG+  ++C+C  G R    G  C                        S
Sbjct: 87   CAGRGVCQSSVVAGTARFSCRCPRGFR----GPDC------------------------S 118

Query: 830  LRSECCATLGAAWGSPCE---RCEIDP------ACARGFARMTGVTC-DDVNECESFPGV 879
            L   C +       SPC    RC + P      +C  G+    G +C  DV+EC      
Sbjct: 119  LPDPCLS-------SPCAHGARCSVGPDGRFLCSCPPGYQ---GRSCRSDVDECRVGEPC 168

Query: 880  CPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC--GVTLPGKYRMD 937
               G C+NT GSFRC+CP G     +G LC +  + PC        C  G T      + 
Sbjct: 169  RHGGTCLNTPGSFRCQCPAGY----TGPLCENPAV-PCA----PSPCRNGGTCRQSGDLT 219

Query: 938  VCCCSIGAVWGVECEA----CPDPESLEFASLCPRGLGFASRDF---LSGRPFYKDVNEC 990
              C  +    G  CE     CP    L     C  G+   +       +G+   +DV+EC
Sbjct: 220  YDCACLPGFEGQNCEVNVDDCPGHRCLN-GGTCVDGVNTYNCQCPPEWTGQFCTEDVDEC 278

Query: 991  KVFPGLCTHG-TCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTP 1048
            ++ P  C +G TC NT+G   C C  G+  ++  +N   ID+C  +  +C  G TC +  
Sbjct: 279  QLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQN---IDDCATA--VCFHGATCHDRV 333

Query: 1049 GSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTD---GSYKCQCPPGHELT 1105
             SF C C P  ++G +    C   D C  +P  C      +T+   G   C CPPG    
Sbjct: 334  ASFYCAC-PMGKTGLL----CHLDDACVSNP--CHEDAICDTNPVNGRAICTCPPGFT-- 384

Query: 1106 AKGTACE-DIDECSLSDGLCPH-GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQN 1163
              G AC+ D+DECS+    C H G+CVN  G+F C C  G+          D+NEC   +
Sbjct: 385  --GGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE---TDVNECL--S 437

Query: 1164 GGC--DVHCINTEGSYRCSCGQGYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHR 1220
            G C     C++  G + C C  G++    G  C  D+DEC+ +P V + G C +   G  
Sbjct: 438  GPCRNQATCLDRIGQFTCICMAGFT----GTYCEVDIDECQSSPCV-NGGVCKDRVNGFS 492

Query: 1221 CLCYDGFMATPDMRTC-VDVDECDLNPHICLHG-DCENTKGSFVCHCQLGYMVRKGATGC 1278
            C C  GF  +    TC +DVDEC   P  C +G  C +    + C C  G+   +G    
Sbjct: 493  CTCPSGFSGS----TCQLDVDECASTP--CRNGAKCVDQPDGYECRCAEGF---EGTLCD 543

Query: 1279 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDC 1338
             +VD+C     +   H  C++   SFSC C PG+ G   E   +DEC SQ   C   G C
Sbjct: 544  RNVDDCSPDPCH---HGRCVDGIASFSCACAPGYTGTRCESQ-VDECRSQP--CRHGGKC 597

Query: 1339 LNVPGSYRCTCRQGFAGDGFFCE-DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTE 1397
            L++   Y C C  G  G    CE + D+CA N   C  G C +    Y C C+ GF    
Sbjct: 598  LDLVDKYLCRCPSGTTGVN--CEVNIDDCASNP--CTFGVCRDGINRYDCVCQPGFTGP- 652

Query: 1398 DHRACQ-DVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCI 1456
                C  +++ECA       GSC +    FRC+C  G         C   +       C 
Sbjct: 653  ---LCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPL----CLPPSHPCAHEPCS 705

Query: 1457 NGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTR 1516
            +G+C + PG + C C   +    SG  C  + A +       R  +G +CS++ G+G   
Sbjct: 706  HGICYDAPGGFRCVCEPGW----SGPRCSQSLARDACESQPCR--AGGTCSSD-GMGF-H 757

Query: 1517 ASC--------CCSLGRAWGNPCE---------------LCPMA----NTTEYRTLCPGG 1549
             +C        C  L     NPCE                CP         +    C G 
Sbjct: 758  CTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGP 817

Query: 1550 EGFQPNRITVIL------------------EDIDECQELPGLCQGGDCVNTFGSFQCECP 1591
                P+ I   L                  +DI++C   P L  GG C +  GSF C C 
Sbjct: 818  APCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCL-NGGSCQDGVGSFSCSCL 876

Query: 1592 PGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKS 1651
            PG+      R   D+DEC ++   CGPGTC + + ++TC CP  Y   +   +  D   S
Sbjct: 877  PGF---AGPRCARDVDECLSNP--CGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPS 931

Query: 1652 VCFRHYNGTCQNELAFNVTRKMCC-------CSYNIGQAWNRPCEACPTPISPDYQILCG 1704
             CF    GTC + +  N    +C        C +      +RPC          +  +C 
Sbjct: 932  SCFN--GGTCVDGV--NSFSCLCRPGYTGAHCQHEADPCLSRPCL---------HGGVCS 978

Query: 1705 NQAPGF---LTDIHTGKPLD--IDECGEIPAICANGICINQIGSFRCECPAGFNYNSI-- 1757
               PGF     +  TG      +D C   P  C NG    Q G++ C CP G++      
Sbjct: 979  AAHPGFRCTCLESFTGPQCQTLVDWCSRQP--CQNGGRCVQTGAY-CLCPPGWSGRLCDI 1035

Query: 1758 -LLAC-EDVDECGSR-ESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGR-NECREIP 1813
              L C E   + G R E  CQ    C++   S+ C C  G     G  C    + C   P
Sbjct: 1036 RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG---RTGSHCEQEVDPCLAQP 1092

Query: 1814 NVCSHGD-CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNG-TCKNIIGSYNCL 1871
              C HG  C    G YMC C  G+     +    D+DEC  QPC +G +C +++  Y C 
Sbjct: 1093 --CQHGGTCRGYMGGYMCECLPGYNGDNCED---DVDECASQPCQHGGSCIDLVARYLCS 1147

Query: 1872 CFPGFVVT----HNGDCVDFDECTTLVGQVCRF-GHCLNTAGSFHCLCQDGFELTADGKN 1926
            C PG +      +  DC       +  G  C   G C++  G F C C  G+     G  
Sbjct: 1148 CPPGTLGVLCEINEDDCGPGPPLDS--GPRCLHNGTCVDLVGGFRCTCPPGYT----GLR 1201

Query: 1927 C-VDTNECLSLAGTCLPG----TCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCL 1981
            C  D NEC S  G C         Q+  G FRC+C  GF       + +  C  +P  C 
Sbjct: 1202 CEADINECRS--GACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTV-LSPCESQP--CQ 1256

Query: 1982 FG-TCTNSPG-----SFQCLCPPGFVLSDNGHRCFDTRQSF----------CFTRFEAGK 2025
             G  C  SPG     +F C C   F     G RC    +S           C       +
Sbjct: 1257 HGGQCRPSPGPGGGLTFTCHCAQPFW----GPRCERVARSCRELQCPVGVPCQQTPRGPR 1312

Query: 2026 CSVPKAFNTTKTRCCCSKRPGEGWGDPCELCP--QEGSAAFQELCPFGHGAVP----GPD 2079
            C+ P   +    R      PG      C   P    GS     L PF   A      GP 
Sbjct: 1313 CACPPGLSGPSCRSFPGSPPGAS-NASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPR 1371

Query: 2080 -DSREDVNECAENPGVCTNGVCVNTDGSFRC--ECPF-GYSLD----------------- 2118
             ++     E +E P  C    C    G  RC  EC   G   D                 
Sbjct: 1372 CEAPAAAPEVSEEPR-CPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEA 1430

Query: 2119 ------FTGINC----------VDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM 2162
                  F    C           D  +C  G    + TC  V   +E  CAD F  G   
Sbjct: 1431 LQCWRLFNNSRCDPACSSPACLYDNFDCHAGGR--ERTCNPV---YEKYCADHFADGRCD 1485

Query: 2163 TCEDIDECSLNPLLCA 2178
               + +EC  + L CA
Sbjct: 1486 QGCNTEECGWDGLDCA 1501



 Score =  382 bits (981), Expect = e-105
 Identities = 391/1344 (29%), Positives = 532/1344 (39%), Gaps = 272/1344 (20%)

Query: 431  YRCECNVGYTQDVRG-ECIDVDECTSSPCHHGDCVNI--PGTYHCRCYPGFQATPTRQAC 487
            + C C  G+    RG +C   D C SSPC HG   ++   G + C C PG+Q    R   
Sbjct: 104  FSCRCPRGF----RGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS-- 157

Query: 488  VDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGF--------------------------- 520
             DVDEC V     H G C+NT GSF+C C AG+                           
Sbjct: 158  -DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSG 216

Query: 521  ELSPD--------GKNC-VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCM 571
            +L+ D        G+NC V+ ++C        G C++   +++C C P +     G +C 
Sbjct: 217  DLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT----GQFCT 272

Query: 572  -DIDECQ-TPGICVN-GHCTNTEGSFRCQCLGG-----LAVGTDGRVCVDTHVRSTCYGA 623
             D+DECQ  P  C N G C NT G   C C+ G      +   D          +TC+  
Sbjct: 273  EDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDR 332

Query: 624  IEKGSCARPFPGT---VTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG 680
            +    CA P   T       + C +NP H     C   P       +A+C+   G T   
Sbjct: 333  VASFYCACPMGKTGLLCHLDDACVSNPCHE-DAICDTNPVNG----RAICTCPPGFTGGA 387

Query: 681  --RDINECALDPEVCAN-GVCENLRGSYRCVCNLGYEAGASGKDC-TDVDECALNSLLCD 736
              +D++EC++    C + G C N +GS+ C C  GY    +G  C TDV+EC L+    +
Sbjct: 388  CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNEC-LSGPCRN 442

Query: 737  NGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVS-GVCRNLAGSYTCKC---- 791
               C +  G ++C C  GF     T    D+DEC SSPCV+ GVC++    ++C C    
Sbjct: 443  QATCLDRIGQFTCICMAGF---TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF 499

Query: 792  -GPGSRLD---------PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAA 841
             G   +LD          +G  C+D   G       E RC    +G    + C   +   
Sbjct: 500  SGSTCQLDVDECASTPCRNGAKCVDQPDG------YECRCAEGFEG----TLCDRNVDDC 549

Query: 842  WGSPCE--RC-----EIDPACARGFARMTGVTCD-DVNECESFPGVCPN-GRCVNTAGSF 892
               PC   RC         ACA G+   TG  C+  V+EC S P  C + G+C++    +
Sbjct: 550  SPDPCHHGRCVDGIASFSCACAPGY---TGTRCESQVDECRSQP--CRHGGKCLDLVDKY 604

Query: 893  RCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC--GVTLPGKYRMDVCCCS---IGAVW 947
             C CP G     +G  C +V ++ C      + C  GV   G  R D C C     G + 
Sbjct: 605  LCRCPSG----TTGVNC-EVNIDDC----ASNPCTFGVCRDGINRYD-CVCQPGFTGPLC 654

Query: 948  GVECEACPDPESLE----------FASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLC 997
             VE   C      E          F  LCP G    S   L   P +   +E       C
Sbjct: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPG----SLPPLCLPPSHPCAHE------PC 704

Query: 998  THGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFP 1057
            +HG C +  G F C C  G++     ++    D C   P   G GTC +    F C C P
Sbjct: 705  SHGICYDAPGGFRCVCEPGWSGPRCSQSLAR-DACESQPCRAG-GTCSSDGMGFHCTCPP 762

Query: 1058 GYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYK-CQCPPGHELTAKGTAC-EDID 1115
            G +      + C  +  C  +P    GG C +  G    C CP G +    G  C +D+D
Sbjct: 763  GVQG-----RQCELLSPCTPNPCE-HGGRCESAPGQLPVCSCPQGWQ----GPRCQQDVD 812

Query: 1116 ECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQ---NGGCDVHCIN 1172
            EC+      PHG C N+ G+F C+CH G+      Q   DIN+C      NGG    C +
Sbjct: 813  ECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ---DINDCDPNPCLNGG---SCQD 866

Query: 1173 TEGSYRCSCGQGYSLMPDGRACA-DVDECEENPRVCDQGHCTNMPGGHRCLC---YDGFM 1228
              GS+ CSC  G++    G  CA DVDEC  NP  C  G CT+      C C   Y GF 
Sbjct: 867  GVGSFSCSCLPGFA----GPRCARDVDECLSNP--CGPGTCTDHVASFTCTCPPGYGGFH 920

Query: 1229 ATPDMRTCVDVDECDLNPHICLH-GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVG 1287
               D+  C        +P  C + G C +   SF C C+ GY    GA    + D C   
Sbjct: 921  CEQDLPDC--------SPSSCFNGGTCVDGVNSFSCLCRPGY---TGAHCQHEADPCL-- 967

Query: 1288 GHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRC 1347
               C     C      F C CL  + G   +C  L +  S++  C   G C+   G+Y C
Sbjct: 968  SRPCLHGGVCSAAHPGFRCTCLESFTGP--QCQTLVDWCSRQ-PCQNGGRCVQT-GAY-C 1022

Query: 1348 TCRQGFAGDGFFCEDRD----ECAENV-----DLCD-NGQCLNAPGGYRCECEMGFDPTE 1397
             C  G++G    C+ R     E A  +      LC   GQC++    + C C  G   T 
Sbjct: 1023 LCPPGWSGR--LCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG--RTG 1078

Query: 1398 DHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-TDINECADPVNCI 1456
             H   Q+VD C        G+C    G + C C  GY     G NC  D++ECA      
Sbjct: 1079 SH-CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY----NGDNCEDDVDECASQPCQH 1133

Query: 1457 NGVCINTPGSYLCSCPQD-----FELNPSGVG----------------CVDTRAGNCFLE 1495
             G CI+    YLCSCP        E+N    G                CVD   G  F  
Sbjct: 1134 GGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGG--FRC 1191

Query: 1496 THDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPN 1555
            T   G +G+ C A+I          C  G         C       +R LC    GF   
Sbjct: 1192 TCPPGYTGLRCEADINE--------CRSGACHAAHTRDCLQDPGGGFRCLCHA--GFSGP 1241

Query: 1556 RITVILEDIDECQELPGLCQ-GGDCVNTFG-----SFQCECPPGYHLSEHTRICEDIDEC 1609
            R   +L     C+  P  CQ GG C  + G     +F C C   +      R+     E 
Sbjct: 1242 RCQTVL---SPCESQP--CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCREL 1296

Query: 1610 STHSGICGPGTCYNTLGNYTCVCP 1633
                G+     C  T     C CP
Sbjct: 1297 QCPVGV----PCQQTPRGPRCACP 1316



 Score =  365 bits (937), Expect = e-100
 Identities = 425/1459 (29%), Positives = 559/1459 (38%), Gaps = 298/1459 (20%)

Query: 69   CPGWRTFPGRSQCVVPICRRACGEG-FCSQPNL----CTCADGTLAPSCGVSRGSGCSVS 123
            CP   T P      VP     C  G  C Q       C C  G    +C V+        
Sbjct: 185  CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHR 244

Query: 124  CMNGGTCRGA----SCLCQKGYTGTVCGQPICD-----RGCHNGGRC---IGPNRCACVY 171
            C+NGGTC       +C C   +TG  C + + +       CHNGG C   +G + C CV 
Sbjct: 245  CLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVN 304

Query: 172  GFMGPQCER---DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPA- 227
            G+ G  C +   D  T  CF       C  ++    C        +G+  GL C L  A 
Sbjct: 305  GWTGESCSQNIDDCATAVCFHGAT---CHDRVASFYCA-----CPMGKT-GLLCHLDDAC 355

Query: 228  QPHPCRRGFI---------------PNIHTGAC-QDVDECQAVPGLCQG-GSCVNMVGSF 270
              +PC    I               P    GAC QDVDEC      C+  G CVN  GSF
Sbjct: 356  VSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSF 415

Query: 271  HCRCPVGHRLSDSSAACEDYRAGACFSVL--------FGGRCAGDLAGHYTRRQCCCDRG 322
             C+C  G+          +  +G C +          F   C     G Y    C  D  
Sbjct: 416  LCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTY----CEVDID 471

Query: 323  RCWAAGPVPE-LCPPRGSNEFQQLCAQRLPLLPGHPGLFPGL---LGFGSNGMGPPLGPA 378
             C ++  V   +C  R  N F   C          P  F G    L        P    A
Sbjct: 472  ECQSSPCVNGGVCKDR-VNGFSCTC----------PSGFSGSTCQLDVDECASTPCRNGA 520

Query: 379  RL--NPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECN 436
            +    P G + R            GT   ++ +D C    + C +GRC+   +S+ C C 
Sbjct: 521  KCVDQPDGYECRCAEGFE------GTLC-DRNVDDCS--PDPCHHGRCVDGIASFSCACA 571

Query: 437  VGYTQDVRGECIDVDECTSSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIV 495
             GYT   R E   VDEC S PC HG  C+++   Y CRC  G   T      V++D+C  
Sbjct: 572  PGYT-GTRCES-QVDECRSQPCRHGGKCLDLVDKYLCRCPSG---TTGVNCEVNIDDC-- 624

Query: 496  SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVNGVCLNEDGSFS 554
            +   C  G C +    + CVC  GF     G  C V+ NECA+S     G C++ +  F 
Sbjct: 625  ASNPCTFGVCRDGINRYDCVCQPGFT----GPLCNVEINECASSPCGEGGSCVDGENGFR 680

Query: 555  CLCKPGFL---LAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
            CLC PG L     P  H C        P  C +G C +  G FRC C      G  G  C
Sbjct: 681  CLCPPGSLPPLCLPPSHPC-----AHEP--CSHGICYDAPGGFRCVC----EPGWSGPRC 729

Query: 612  VDTHVRSTCYGAIEK--GSCARP-------FPGTVTKSEC-----CCANP-DHGFGEPCQ 656
              +  R  C     +  G+C+          P  V   +C     C  NP +HG    C+
Sbjct: 730  SQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG--GRCE 787

Query: 657  LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAG 716
              P +        C  G       +D++ECA       +G+C NL GS+ C C+ GY   
Sbjct: 788  SAPGQLPV---CSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY--- 841

Query: 717  ASGKDCT-DVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPC 775
             +G  C  D+++C  N  L + G CQ+  GS+SCSC PGF         +DVDECLS+PC
Sbjct: 842  -TGPSCDQDINDCDPNPCL-NGGSCQDGVGSFSCSCLPGF---AGPRCARDVDECLSNPC 896

Query: 776  VSGVCRNLAGSYTCKCGPG--------SRLDPSGTFCLDSTKGTC--WLKIQESRCEVNL 825
              G C +   S+TC C PG           D S + C +   GTC   +      C    
Sbjct: 897  GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNG--GTCVDGVNSFSCLCRPGY 954

Query: 826  QGASLRSEC--CATLGAAWGSPCERCEIDPACARGFARMTGVTCDD-VNECESFPGVCPN 882
             GA  + E   C +     G  C        C       TG  C   V+ C   P  C N
Sbjct: 955  TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCT-CLESFTGPQCQTLVDWCSRQP--CQN 1011

Query: 883  -GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCC 941
             GRCV T G++ C CP G     SGRLC D+R  PC  R    + GV      R++  C 
Sbjct: 1012 GGRCVQT-GAY-CLCPPGW----SGRLC-DIRSLPC--REAAAQIGV------RLEQLCQ 1056

Query: 942  SIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTH-G 1000
            + G         C D +S  +  +CP G         +G    ++V+ C   P  C H G
Sbjct: 1057 AGG--------QCVDEDSSHYC-VCPEG--------RTGSHCEQEVDPCLAQP--CQHGG 1097

Query: 1001 TCRNTVGSFHCACAGGFALDAQERNC-TDIDECRISPDLCGQGTCVNTPGSFECECFPGY 1059
            TCR  +G + C C  G+  D    NC  D+DEC   P   G G+C++    + C C PG 
Sbjct: 1098 TCRGYMGGYMCECLPGYNGD----NCEDDVDECASQPCQHG-GSCIDLVARYLCSCPPG- 1151

Query: 1060 ESGFMLMKNC-MDVDECARDPLLCRG------GTCTNTDGSYKCQCPPGHELTAKGTACE 1112
                 L   C ++ D+C   P L  G      GTC +  G ++C CPPG+     G  CE
Sbjct: 1152 ----TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY----TGLRCE 1203

Query: 1113 -DIDECSLSDGLCPHGQCVNVI----GAFQCSCHAGFQSTPDRQGCVDINECR-VQNGGC 1166
             DI+EC    G C      + +    G F+C CHAGF S P  Q  +   E +  Q+GG 
Sbjct: 1204 ADINEC--RSGACHAAHTRDCLQDPGGGFRCLCHAGF-SGPRCQTVLSPCESQPCQHGG- 1259

Query: 1167 DVHCINTEG-----SYRCSCGQGYSLMPDGRACADV-DECEENPRVCDQG-HCTNMPGGH 1219
               C  + G     ++ C C Q +     G  C  V   C E    C  G  C   P G 
Sbjct: 1260 --QCRPSPGPGGGLTFTCHCAQPFW----GPRCERVARSCRE--LQCPVGVPCQQTPRGP 1311

Query: 1220 RCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCS 1279
            RC C  G                           C +  GS             GA+  S
Sbjct: 1312 RCACPPGLSGP----------------------SCRSFPGS-----------PPGASNAS 1338

Query: 1280 DVDECEVGGHNCDSHASCLNIPGS--FSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGD 1337
                       C    SC   P +  F C C  GW G   E       VS+E RC PR  
Sbjct: 1339 ------CAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRC-PRAA 1391

Query: 1338 CLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVD----LCDNGQCLNAPGGYRCECEMGF 1393
            C    G  RC       G G+   D  +C+ +V      C+  QC       RC      
Sbjct: 1392 CQAKRGDQRCDRECNSPGCGW---DGGDCSLSVGDPWRQCEALQCWRLFNNSRC------ 1442

Query: 1394 DPTEDHRAC-QDVDECAQG 1411
            DP     AC  D  +C  G
Sbjct: 1443 DPACSSPACLYDNFDCHAG 1461



 Score =  359 bits (921), Expect = 2e-98
 Identities = 358/1256 (28%), Positives = 485/1256 (38%), Gaps = 300/1256 (23%)

Query: 1531 CELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDC-VNTFGSFQCE 1589
            C+   +A T  +   CP   GF+    ++     D C   P    G  C V   G F C 
Sbjct: 93   CQSSVVAGTARFSCRCP--RGFRGPDCSLP----DPCLSSP-CAHGARCSVGPDGRFLCS 145

Query: 1590 CPPGYHLSEHTRICE-DIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDM 1648
            CPPGY      R C  D+DEC         GTC NT G++ C CPA Y      N  +  
Sbjct: 146  CPPGYQ----GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPC 201

Query: 1649 RKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAP 1708
              S C     GTC+   + ++T    C     GQ      + CP           G++  
Sbjct: 202  APSPC--RNGGTCRQ--SGDLTYDCACLPGFEGQNCEVNVDDCP-----------GHR-- 244

Query: 1709 GFLTDIHTGKPLDIDECGEIPAICANG-ICINQIGSFRCECPAGFNYNSILLACEDVDEC 1767
                                   C NG  C++ + ++ C+CP  +         EDVDEC
Sbjct: 245  -----------------------CLNGGTCVDGVNTYNCQCPPEWTGQ---FCTEDVDEC 278

Query: 1768 GSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGR-NECREIPNVCSHG-DCMDTE 1825
              + + C     C N  G + C C  G+    G +C    ++C     VC HG  C D  
Sbjct: 279  QLQPNACHNGGTCFNTLGGHSCVCVNGWT---GESCSQNIDDCATA--VCFHGATCHDRV 333

Query: 1826 GSYMCLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKN--IIGSYNCLCFPGFVVTHNG 1882
             S+ C C  G        LC   D C   PC  +  C    + G   C C PGF     G
Sbjct: 334  ASFYCACPMGKTG----LLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFT---GG 386

Query: 1883 DC-VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNC-VDTNECLSLAGTC 1940
             C  D DEC+         G C+NT GSF C C  G+     G  C  D NECLS  G C
Sbjct: 387  ACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT----GPRCETDVNECLS--GPC 440

Query: 1941 L-PGTCQNLEGSFRCICPPGFQVQSDHC-IDIDECSEEPNLCLFG-TCTNSPGSFQCLCP 1997
                TC +  G F CIC  GF     +C +DIDEC   P  C+ G  C +    F C CP
Sbjct: 441  RNQATCLDRIGQFTCICMAGFT--GTYCEVDIDECQSSP--CVNGGVCKDRVNGFSCTCP 496

Query: 1998 PGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCP 2057
             GF    +G  C          + +  +C+     N  K    C  +P +G+   C    
Sbjct: 497  SGF----SGSTC----------QLDVDECASTPCRNGAK----CVDQP-DGYECRCA--- 534

Query: 2058 QEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSL 2117
             EG      LC               +V++C+ +P  C +G CV+   SF C C  GY  
Sbjct: 535  -EGFEG--TLCD-------------RNVDDCSPDP--CHHGRCVDGIASFSCACAPGY-- 574

Query: 2118 DFTGINCVD-TDECSVGHPCGQG-TCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNP 2174
              TG  C    DEC    PC  G  C +++  + C C  G      + CE +ID+C+ NP
Sbjct: 575  --TGTRCESQVDECR-SQPCRHGGKCLDLVDKYLCRCPSGTTG---VNCEVNIDDCASNP 628

Query: 2175 LLCAFR-CHNTEGSYLCTCPAGYTLREDGAMCR-DVDECADGQQDCHARGMECKNLIGTF 2232
              C F  C +    Y C C  G+T    G +C  +++ECA     C   G  C +    F
Sbjct: 629  --CTFGVCRDGINRYDCVCQPGFT----GPLCNVEINECASSP--C-GEGGSCVDGENGF 679

Query: 2233 ACVCPPGMRP---LPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
             C+CPPG  P   LP S       + C  +P  C +G C +  G FRC C+ G+   P  
Sbjct: 680  RCLCPPGSLPPLCLPPS-------HPCAHEP--CSHGICYDAPGGFRCVCEPGWS-GPRC 729

Query: 2290 TECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGG-RG---------------WG 2333
            ++   + +  C ++     CR+  + S       C C  G +G                G
Sbjct: 730  SQ--SLARDACESQP----CRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG 783

Query: 2334 PRCELCP--LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQ 2391
             RCE  P  LP  S     CP G       +DVDEC   A    HG C N  GSF C C 
Sbjct: 784  GRCESAPGQLPVCS-----CPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCH 838

Query: 2392 AGYTPDATATTCLDMDECSQVPKPCTF--LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDE 2449
             GYT  +      D+++C   P PC     C++  GSF CSC  G+      R  +D+DE
Sbjct: 839  GGYTGPSCDQ---DINDCD--PNPCLNGGSCQDGVGSFSCSCLPGFA---GPRCARDVDE 890

Query: 2450 CTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH----------QACFDND---------ECS 2490
            C S        C + V +FTC CPPG+   H           +CF+            C 
Sbjct: 891  CLSNPCG-PGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCL 949

Query: 2491 AQPGPCGAH----------------GHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG 2534
             +PG  GAH                G C      FRC C + FT    G  C+ + +   
Sbjct: 950  CRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFT----GPQCQTLVDWCS 1005

Query: 2535 PHRCQHGCQNQLGGYRCSCPQGFTQH------------------------SQWAQCVDEN 2570
               CQ+G +    G  C CP G++                              QCVDE+
Sbjct: 1006 RQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDED 1065

Query: 2571 EC--------------------ALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQ- 2609
                                   L+ P     +CR  +GG+ C C  G++ D     C+ 
Sbjct: 1066 SSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGD----NCED 1121

Query: 2610 EVDECAGRRGPCSY--SCANTPGGFLCGCPQGYF----RAGQGHCVSGLGFSPGPQ 2659
            +VDECA +  PC +  SC +    +LC CP G         +  C  G     GP+
Sbjct: 1122 DVDECASQ--PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPR 1175



 Score =  349 bits (896), Expect = 2e-95
 Identities = 308/998 (30%), Positives = 430/998 (43%), Gaps = 168/998 (16%)

Query: 1732 CANGICINQIGSFR--CECPAGFNYNSILLACEDVDECGSRESPCQQNADCIN--IPGSY 1787
            CANG    Q+ S    C CP G+    +   C+  D C S   PC     C +  + G+ 
Sbjct: 49   CANGGRCTQLPSREAACLCPPGW----VGERCQLEDPCHS--GPCAGRGVCQSSVVAGTA 102

Query: 1788 R--CKCTRGYKLSPGGACVGRNECREIPNVCSHGD--CMDTEGSYMCLCHRGFQASADQT 1843
            R  C+C RG++   G  C   + C   P  C+HG    +  +G ++C C  G+Q  + ++
Sbjct: 103  RFSCRCPRGFR---GPDCSLPDPCLSSP--CAHGARCSVGPDGRFLCSCPPGYQGRSCRS 157

Query: 1844 LCMDIDECD-RQPCGNG-TCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFG 1901
               D+DEC   +PC +G TC N  GS+ C C  G+     G   + +         CR G
Sbjct: 158  ---DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT----GPLCE-NPAVPCAPSPCRNG 209

Query: 1902 HCLNTAG--SFHCLCQDGFELTADGKNC-VDTNECLSLAGTCLPG-TCQNLEGSFRCICP 1957
                 +G  ++ C C  GFE    G+NC V+ ++C      CL G TC +   ++ C CP
Sbjct: 210  GTCRQSGDLTYDCACLPGFE----GQNCEVNVDDCPG--HRCLNGGTCVDGVNTYNCQCP 263

Query: 1958 PGFQVQSDHCI-DIDECSEEPNLCLFG-TCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQS 2015
            P +  Q   C  D+DEC  +PN C  G TC N+ G   C+C  G+          D   +
Sbjct: 264  PEWTGQ--FCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATA 321

Query: 2016 FCF------TRFEAGKCSVPKAFNTTKTRC----CCSKRPGEGWGDPCELCPQEGSAAFQ 2065
             CF       R  +  C+ P     T   C     C   P       C+  P  G A   
Sbjct: 322  VCFHGATCHDRVASFYCACP--MGKTGLLCHLDDACVSNPCHE-DAICDTNPVNGRA--- 375

Query: 2066 ELCPFGHGAVPGPDDSREDVNECAENPGVCTN-GVCVNTDGSFRCECPFGYSLDFTGINC 2124
             +C    G   G  D  +DV+EC+     C + G CVNT GSF C+C  GY    TG  C
Sbjct: 376  -ICTCPPGFTGGACD--QDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRC 428

Query: 2125 -VDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNPLLCAFRCH 2182
              D +EC  G    Q TC + IG F C C  GF       CE DIDEC  +P +    C 
Sbjct: 429  ETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTY---CEVDIDECQSSPCVNGGVCK 485

Query: 2183 NTEGSYLCTCPAGYTLREDGAMCR-DVDECADGQQDCHARGMECKNLIGTFACVCPPGMR 2241
            +    + CTCP+G++    G+ C+ DVDECA     C   G +C +    + C C  G  
Sbjct: 486  DRVNGFSCTCPSGFS----GSTCQLDVDECAS--TPCR-NGAKCVDQPDGYECRCAEGFE 538

Query: 2242 PLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPC- 2300
                 G  C D N     PD C +GRCV+   SF C C  G+  +   ++  + R  PC 
Sbjct: 539  -----GTLC-DRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCR 592

Query: 2301 -----FAEVLQTMCRSLSSSS----------------------EAVTRAECCCGGGRGWG 2333
                    V + +CR  S ++                      + + R +C C  G   G
Sbjct: 593  HGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFT-G 651

Query: 2334 PRCEL----CP----------LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHL-CAHGE 2378
            P C +    C           + G + +R LCP GS        +      AH  C+HG 
Sbjct: 652  PLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGS---LPPLCLPPSHPCAHEPCSHGI 708

Query: 2379 CINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLE 2438
            C ++ G FRC C+ G++    + + L  D C   P      C +    F C+CP G    
Sbjct: 709  CYDAPGGFRCVCEPGWSGPRCSQS-LARDACESQPCRAGGTCSSDGMGFHCTCPPGV--- 764

Query: 2439 EDGRTCKDLDECTSRQHNCQFLCVNTVGAF-TCRCPPGFTQHHQACFDNDECSAQPGPCG 2497
              GR C+ L  CT         C +  G    C CP G+ Q  +   D DEC A P PCG
Sbjct: 765  -QGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGW-QGPRCQQDVDEC-AGPAPCG 821

Query: 2498 AHGHCHNTPGSFRCECHQGFTLVSSGHGC-EDVNECDGPHRCQHG--CQNQLGGYRCSCP 2554
             HG C N  GSF C CH G+T    G  C +D+N+CD P+ C +G  CQ+ +G + CSC 
Sbjct: 822  PHGICTNLAGSFSCTCHGGYT----GPSCDQDINDCD-PNPCLNGGSCQDGVGSFSCSCL 876

Query: 2555 QGFTQHSQWAQCV-DENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC---QE 2610
             GF       +C  D +EC  +P  CG  +C + +  F C CP G+      GG    Q+
Sbjct: 877  PGFA----GPRCARDVDECLSNP--CGPGTCTDHVASFTCTCPPGY------GGFHCEQD 924

Query: 2611 VDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHC 2648
            + +C+        +C +    F C C  GY  A   HC
Sbjct: 925  LPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGA---HC 959



 Score = 92.0 bits (227), Expect = 7e-18
 Identities = 168/674 (24%), Positives = 205/674 (30%), Gaps = 204/674 (30%)

Query: 64   FHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQ---PNLCTCADGTLAPSCGVSRGSGC 120
            F   C PG+   P  ++ V       CG G C+       CTC  G     C        
Sbjct: 871  FSCSCLPGFAG-PRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCS 929

Query: 121  SVSCMNGGTC----RGASCLCQKGYTGTVC---GQPICDRGCHNGGRCIGPN---RCACV 170
              SC NGGTC       SCLC+ GYTG  C     P   R C +GG C   +   RC C+
Sbjct: 930  PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCL 989

Query: 171  YGFMGPQCE---------------RDYRTGP-CFGQVGPEGCQHQLTGLVCTKAL----- 209
              F GPQC+               R  +TG  C    G  G    +  L C +A      
Sbjct: 990  ESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGV 1049

Query: 210  --------------------CCATVGRAWGLPCE--LCPAQPHPCRRG------------ 235
                                C    GR  G  CE  + P    PC+ G            
Sbjct: 1050 RLEQLCQAGGQCVDEDSSHYCVCPEGRT-GSHCEQEVDPCLAQPCQHGGTCRGYMGGYMC 1108

Query: 236  -FIPNIHTGACQD-VDECQAVP----GLC------------------------------- 258
              +P  +   C+D VDEC + P    G C                               
Sbjct: 1109 ECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGP 1168

Query: 259  ---------QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLA 309
                       G+CV++VG F C CP G+      A   + R+GAC +      C  D  
Sbjct: 1169 PLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAA-HTRDCLQDPG 1227

Query: 310  GHYTRRQCCCDRG----RCWAAGPVPELCP------------PRGSNEFQQLCAQRL--P 351
            G +   +C C  G    RC       E  P            P G   F   CAQ    P
Sbjct: 1228 GGF---RCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGP 1284

Query: 352  LLPGHPGLFPGL-LGFGSNGMGPPLGPARLNP---HGSDARGIPSLGPGNSNIGTATLNQ 407
                       L    G      P GP    P    G   R  P   PG SN   A    
Sbjct: 1285 RCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAP- 1343

Query: 408  TIDICRHFTNLCLNGRCLPTPSS--YRCECNVGYT------------------------Q 441
                C H       G C P P +  +RC C  G+T                        Q
Sbjct: 1344 ----CLH------GGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQ 1393

Query: 442  DVRGECIDVDECTSSPC--HHGDCVNIPGT--YHC---RCYPGFQATPTRQACVDVDECI 494
              RG+     EC S  C    GDC    G     C   +C+  F  +    AC     C+
Sbjct: 1394 AKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPAC-SSPACL 1452

Query: 495  VSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDG--S 552
                 CH G    T       CN  +E     K C DH        C  G    E G   
Sbjct: 1453 YDNFDCHAGGRERT-------CNPVYE-----KYCADH---FADGRCDQGCNTEECGWDG 1497

Query: 553  FSCLCKPGFLLAPG 566
              C  +   LLA G
Sbjct: 1498 LDCASEVPALLARG 1511



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 44/163 (26%), Positives = 55/163 (33%), Gaps = 47/163 (28%)

Query: 61   GSRFHAYCC-PGWRTFPGRSQCVVPICRRA-CGEGFCSQPN----LCTCADGTLAPSC-- 112
            G  F  +C  P W     R + V   CR   C  G   Q       C C  G   PSC  
Sbjct: 1270 GLTFTCHCAQPFWGP---RCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRS 1326

Query: 113  ------GVSRGSGCSVSCMNGGTCRGAS------CLCQKGYTGTVCGQPI---------- 150
                  G S  S  +  C++GG+CR A       C C +G+TG  C  P           
Sbjct: 1327 FPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPR 1386

Query: 151  --------------CDRGCHNGGRCIGPNRCACVYGFMGPQCE 179
                          CDR C++ G       C+   G    QCE
Sbjct: 1387 CPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCE 1429


>gi|18497288 latent transforming growth factor beta binding protein 3
            isoform 2 [Homo sapiens]
          Length = 1256

 Score =  429 bits (1102), Expect = e-119
 Identities = 306/996 (30%), Positives = 411/996 (41%), Gaps = 165/996 (16%)

Query: 745  GSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTF 803
            G     CP G+     T  C+D++EC +   C  G C N  GSY C C PG  L PS T 
Sbjct: 335  GEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 804  CL---DSTKGTCWLKIQ-ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF 859
            C+      K  C+  +  E +C+  L     R  CC ++G AWG+ C+RC  D   A   
Sbjct: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA--- 450

Query: 860  ARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFL 919
                            F  +CP G+  +   S +    +G   D S  L  D   +P  L
Sbjct: 451  ----------------FKEICPAGKGYHILTSHQTLTIQGES-DFSLFLHPDGPPKPQQL 493

Query: 920  RWD----------EDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969
                         E+E GVT       +               A P PE +   S  P  
Sbjct: 494  PESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPT-ATTTPARPYPELISRPS--PPT 550

Query: 970  LGFASRDFLSGRPFYK-------DVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
            + +   D    R   +       + +EC++   +C HG C      + C C  G+    Q
Sbjct: 551  MRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQ 610

Query: 1023 ERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFML-MKNCMDVDECARDPLL 1081
             R C D++EC   P   G+G C+NT GS+ C C  GY        ++C+D++ECA+  L 
Sbjct: 611  HRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLC 670

Query: 1082 CRGGTCTNTDGSYKCQCPPGHELTA-KGTACEDIDECSLSDGLCPHGQCVNVIGAFQC-S 1139
              GG C N  G YKC C PG+ L A +   CEDIDEC      CP G+C N  G+F+C +
Sbjct: 671  GDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIA 729

Query: 1140 CHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDE 1199
            C  G++S      C D+NEC   +      C N  GS+RC+C QGY+  PDGR+C DVDE
Sbjct: 730  CQPGYRS-QGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDE 788

Query: 1200 CEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKG 1259
            CE    VCD G C+N PG  +C C  G+  + D   C D+DECD  P  C+ GDC NT G
Sbjct: 789  CEAGD-VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNG 846

Query: 1260 SFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319
            S+ C C  G+ +  G   C D+DEC      C  H +C N+ GS+ C C  G+     + 
Sbjct: 847  SYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQ-DQ 904

Query: 1320 HDLDECVSQEHR--CSPRGD----CLNVPGS----YRCTCRQGFAGDGFFCE-------- 1361
            H  +E     H+  C    D    C +V  +      C C  G AG G  CE        
Sbjct: 905  HGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLG-AGWGDHCEIYPCPVYS 963

Query: 1362 -----------------------------DRDEC-AENVDLCDNGQCLNAPGGYRCECEM 1391
                                         D DEC     ++C  G+C+N   GY C C+ 
Sbjct: 964  SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQ 1023

Query: 1392 GFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECAD 1451
            GF    +   C DVDEC   + C  G CEN  G +RC C    E                
Sbjct: 1024 GFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEY--------------- 1068

Query: 1452 PVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIG 1511
                       +P    C  P++ E  P        R   C+ +   RG+ G+      G
Sbjct: 1069 -----------SPAQRQCLSPEEMERAPE-------RRDVCWSQ---RGEDGMCAGPLAG 1107

Query: 1512 VGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGE--------------GFQPNRI 1557
              +T   CCC  GR WG  C  CP      +   CP  +              G  P   
Sbjct: 1108 PALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSPLLLGKPPRDE 1164

Query: 1558 TVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDEC---STHSG 1614
                ED DEC+     C  G CV   G   CECP G+ L      C DIDEC   +    
Sbjct: 1165 DSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGL 1219

Query: 1615 ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRK 1650
            +C    C NT G++ CVC A + +      C+  R+
Sbjct: 1220 LCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRR 1255



 Score =  410 bits (1055), Expect = e-114
 Identities = 253/696 (36%), Positives = 342/696 (49%), Gaps = 64/696 (9%)

Query: 1155 DINECRVQNGGCDV-HCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCT 1213
            + +ECR+    C    C+     Y C C  GY   P  R C DV+ECE  P    +G C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 1214 NMPGGHRCLCYDGFMATPDM--RTCVDVDECDLNPHICLHGD-CENTKGSFVCHCQLGYM 1270
            N  G + C C  G+        R+CVD++EC   PH+C  G  C N  G + C+C  GY 
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYR 692

Query: 1271 VRKGATG-CSDVDECEVGGHNCDSHASCLNIPGSFSC-RCLPGWVGDGF-ECHDLDECVS 1327
            ++      C D+DEC       D    C N PGSF C  C PG+   G   C D++EC +
Sbjct: 693  LKASRPPVCEDIDECRDPSSCPDG--KCENKPGSFKCIACQPGYRSQGGGACRDVNEC-A 749

Query: 1328 QEHRCSPRGDCLNVPGSYRCTCRQGFAG--DGFFCEDRDECAENVDLCDNGQCLNAPGGY 1385
            +   CSP G C N+PGS+RCTC QG+A   DG  C D DEC E  D+CDNG C N PG +
Sbjct: 750  EGSPCSP-GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGICSNTPGSF 807

Query: 1386 RCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTD 1445
            +C+C  G+  + D   C+D+DEC     C  G C N  G +RC+C  G+ L  GG  C D
Sbjct: 808  QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQD 866

Query: 1446 INECA-DPVNCI-NGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSG 1503
            I+EC+ DP  C+ +G C N  GSY+C C + F       GC +    +   E +   D  
Sbjct: 867  IDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDT 926

Query: 1504 ISCSAEIGVGVTRASCCCSLGRAWGNPCEL--CPMANTTEYRTLCPGGEGF-QPNRIT-- 1558
            + C + +   VT+  CCCSLG  WG+ CE+  CP+ ++ E+ +LCP G+G+ Q N I   
Sbjct: 927  VFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNY 986

Query: 1559 --VILEDIDECQELPG-LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGI 1615
                  DIDEC      +C+ G CVNT   ++C C  G++   +   C D+DEC   S  
Sbjct: 987  GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN- 1045

Query: 1616 CGPGTCYNTLGNYTCVC--PAEYLQVNGGNNCMDM--------RKSVCF--RHYNGTCQN 1663
            C  G C NT G Y C C  PAEY        C+          R+ VC+  R  +G C  
Sbjct: 1046 CRNGVCENTRGGYRCACTPPAEYSPAQ--RQCLSPEEMERAPERRDVCWSQRGEDGMCAG 1103

Query: 1664 ELAFN-VTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGF--LTDIHTGKPL 1720
             LA   +T   CCC    G+ W   C  CP   +  +     +++  F   + +  GKP 
Sbjct: 1104 PLAGPALTFDDCCCRQ--GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPP 1161

Query: 1721 --------DIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC---GS 1769
                    D DEC      C +G C+ + G   CECP GF  ++    C D+DEC     
Sbjct: 1162 RDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1216

Query: 1770 RESPCQQNADCINIPGSYRCKCTRGYKLS-PGGACV 1804
            R   C+    C+N  GS+RC C  G+  S P GACV
Sbjct: 1217 RGLLCKSER-CVNTSGSFRCVCKAGFARSRPHGACV 1251



 Score =  390 bits (1003), Expect = e-108
 Identities = 308/1019 (30%), Positives = 416/1019 (40%), Gaps = 198/1019 (19%)

Query: 185  GPCFGQVGP-EGC-QHQLTGLVCTKALCCATVGRAWGLP-CELCPA-------QPHP--- 231
            G CF    P + C  + L GL   +  CC ++G AWG   C  CP        +P P   
Sbjct: 277  GRCFQDTLPKQPCGSNPLPGLTKQED-CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRG 335

Query: 232  -----CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286
                 C +G+   +++  CQD++EC A+PG+C+ G C+N  GS+ C CP GH L  S   
Sbjct: 336  EVGADCPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQ 393

Query: 287  C---EDYRAGACFSVLF-GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEF 342
            C   +      CF ++    +C   L    TR+ CCC  G+ W  G   + CP  G+  F
Sbjct: 394  CIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW--GARCQRCPTDGTAAF 451

Query: 343  QQLC--AQRLPLLPGHPGL-FPGLLGFG--SNGMGPPL------GPARLNP--HGSDARG 389
            +++C   +   +L  H  L   G   F    +  GPP        P++  P     + RG
Sbjct: 452  KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERG 511

Query: 390  IPSLGPGNS--NIGTATLNQTIDICRHFTNLCLNGR------CLPTPSSYRCECNVGYTQ 441
            + +  P +   ++  +    T    R +  L            LP     R    +  TQ
Sbjct: 512  VTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQ 571

Query: 442  DVRGECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL 499
                   + DEC    + C HG+CV  P  Y C C PG+++ P  + CVDV+EC      
Sbjct: 572  -----VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCG 626

Query: 500  CHLGRCVNTEGSFQCVCNAGFEL--SPDGKNCVDHNECATSTMCVN-GVCLNEDGSFSCL 556
               G C+NT GS+ C CN G+ L     G++CVD NECA   +C + G C+N  G + C 
Sbjct: 627  PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCN 686

Query: 557  CKPGF-LLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRC-QCLGGLAVGTDGRVCVDT 614
            C PG+ L A     C DIDEC+ P  C +G C N  GSF+C  C  G      G  C D 
Sbjct: 687  CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDV 745

Query: 615  HVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKD-SAEFQALCSSG 673
            +             CA                     G PC     ++    F+  C+ G
Sbjct: 746  N------------ECAE--------------------GSPCSPGWCENLPGSFRCTCAQG 773

Query: 674  LGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECAL 730
                 DGR   D++EC    +VC NG+C N  GS++C C  GY        C D+DEC  
Sbjct: 774  YAPAPDGRSCLDVDECEAG-DVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF 832

Query: 731  NSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCV---SGVCRNLAGSY 787
             +  C  G C N+ GSY C CP G H       C+D+DEC   P +    G C+NL GSY
Sbjct: 833  PA-ACIGGDCINTNGSYRCLCPQG-HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSY 890

Query: 788  TCKCGPGSRLDPSGTFCLD----STKGTCWLKIQES-RCEVNLQGASLRSECCATLGAAW 842
             C C  G         C +      K  C+L   ++  C+  L     + ECC +LGA W
Sbjct: 891  VCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGW 950

Query: 843  GSPCE--------RCEIDPAC--ARGFARMTGV------TCDDVNECESFPG-VCPNGRC 885
            G  CE          E    C   +G+ +   +         D++EC  F   +C  G+C
Sbjct: 951  GDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKC 1010

Query: 886  VNTAGSFRCECPEGLMLDASGRLCVDV--------------------------------- 912
            VNT   + C C +G   D +   CVDV                                 
Sbjct: 1011 VNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSP 1070

Query: 913  ----------------RLEPCFLRWDED-ECGVTLPG-KYRMDVCCCSIGAVWGVECEAC 954
                            R + C+ +  ED  C   L G     D CCC  G  WG +C  C
Sbjct: 1071 AQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPC 1130

Query: 955  P-----------DPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCR 1003
            P             ES  F    P  LG   RD  S     +D +EC+     C  G C 
Sbjct: 1131 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSE---EDSDECR-----CVSGRCV 1182

Query: 1004 NTVGSFHCACAGGFALDAQERNCTDIDECRISPD---LCGQGTCVNTPGSFECECFPGY 1059
               G   C C GGF LDA    C DIDECR       LC    CVNT GSF C C  G+
Sbjct: 1183 PRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241



 Score =  369 bits (946), Expect = e-101
 Identities = 307/1075 (28%), Positives = 438/1075 (40%), Gaps = 221/1075 (20%)

Query: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCC-SLGRAWG-NPCELCPMANTTEYRTLCP 1547
            G CF +T  +      C +    G+T+   CC S+G AWG + C  CP    T  +   P
Sbjct: 277  GRCFQDTLPKQP----CGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQK--P 330

Query: 1548 GGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607
            G     P R                           G    +CP GY     T  C+DI+
Sbjct: 331  G-----PVR---------------------------GEVGADCPQGYKRLNSTH-CQDIN 357

Query: 1608 ECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMR---KSVCFRHYNGT--CQ 1662
            EC+   G+C  G C N  G+Y CVCP  +        C+  +   KS+CFR  +    CQ
Sbjct: 358  ECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQ 416

Query: 1663 NELAFNVTRKMCCCSYNIGQAWNRPCEACPT----------PISPDYQILCGNQA----- 1707
            + L   +TR++CCCS  +G+AW   C+ CPT          P    Y IL  +Q      
Sbjct: 417  HPLTTRLTRQLCCCS--VGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQG 474

Query: 1708 -PGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYN-------SILL 1759
               F   +H   P    +  E P+         +      + P     +       +   
Sbjct: 475  ESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTT 534

Query: 1760 ACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHG 1819
                  E  SR SP        ++P S         +++P       +ECR   N+C HG
Sbjct: 535  PARPYPELISRPSPPTMRWFLPDLPPS-----RSAVEIAPTQV-TETDECRLNQNICGHG 588

Query: 1820 DCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPC--GNGTCKNIIGSYNCLCFPGF- 1876
            +C+     Y C C+ G+++      C+D++EC+ +PC  G G C N  GSYNC C  G+ 
Sbjct: 589  ECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYR 648

Query: 1877 --VVTHNGDCVDFDECTT--LVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN-CVDTN 1931
              V      CVD +EC    L G     G C+N  G + C C  G+ L A     C D +
Sbjct: 649  LHVGAGGRSCVDLNECAKPHLCGD---GGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCI-CPPGFQVQ-SDHCIDIDECSEEPNLCLFGTCTNSP 1989
            EC     +C  G C+N  GSF+CI C PG++ Q    C D++EC+ E + C  G C N P
Sbjct: 706  ECRD-PSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA-EGSPCSPGWCENLP 763

Query: 1990 GSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGW 2049
            GSF+C C  G+  + +G  C D  +       EAG                CS  PG   
Sbjct: 764  GSFRCTCAQGYAPAPDGRSCLDVDEC------EAGDVC---------DNGICSNTPG--- 805

Query: 2050 GDPCELCPQEGSAAFQELCPFGHGAVPGPDDSR-EDVNECAENPGVCTNGVCVNTDGSFR 2108
                         +FQ  C  G+      D S  ED++EC + P  C  G C+NT+GS+R
Sbjct: 806  -------------SFQCQCLSGYHL--SRDRSHCEDIDEC-DFPAACIGGDCINTNGSYR 849

Query: 2109 CECPFGYSLDFTGINCVDTDECSVGHP--CGQGTCTNVIGGFECACADGFEPGL-MMTCE 2165
            C CP G+ L   G  C D DECS         G C N+ G + C C +GF P      CE
Sbjct: 850  CLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCE 908

Query: 2166 DID------ECSLN---PLLC--AFRCHNTEGSYLCTCPAG------------YTLREDG 2202
            +++      EC LN    + C      + T+    C+  AG            Y+  E  
Sbjct: 909  EVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFH 968

Query: 2203 AMC--------------------RDVDEC-ADGQQDCHARGMECKNLIGTFACVCPPGMR 2241
            ++C                    RD+DEC   G + C  +  +C N    + C C  G  
Sbjct: 969  SLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEIC--KEGKCVNTQPGYECYCKQGFY 1026

Query: 2242 PLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC---HDIRQG 2298
               G+   C D +EC  + + C NG C NT G +RC C    + SP   +C    ++ + 
Sbjct: 1027 -YDGNLLECVDVDECLDESN-CRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERA 1084

Query: 2299 P-----CFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPH 2353
            P     C+++  +    +   +  A+T  +CCC  GRGWG +C  CP  G  ++   CP 
Sbjct: 1085 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPT 1141

Query: 2354 GSGYT-------------------AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGY 2394
                +                   +   D DECR     C  G C+   G   C C  G+
Sbjct: 1142 SQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR-----CVSGRCVPRPGGAVCECPGGF 1196

Query: 2395 TPDATATTCLDMDECSQVPKPCTFLCK-----NTKGSFLCSCPRGYLLEEDGRTC 2444
              DA+   C+D+DEC ++ +    LCK     NT GSF C C  G+        C
Sbjct: 1197 QLDASRARCVDIDECRELNQR-GLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250



 Score =  330 bits (845), Expect = 2e-89
 Identities = 218/698 (31%), Positives = 304/698 (43%), Gaps = 79/698 (11%)

Query: 1969 DIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
            + DEC    N+C  G C   P  + C C PG+        C D  +       EA  C  
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC------EAEPCGP 627

Query: 2029 PK--AFNTTKT-RCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSR--- 2082
             +    NT  +  C C++      G     C      A   LC  G   +  P   +   
Sbjct: 628  GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC 687

Query: 2083 --------------EDVNECAENPGVCTNGVCVNTDGSFRC-ECPFGYSLDFTGINCVDT 2127
                          ED++EC  +P  C +G C N  GSF+C  C  GY     G  C D 
Sbjct: 688  YPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDV 745

Query: 2128 DECSVGHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECSLNPLLCAFRCHNTEG 2186
            +EC+ G PC  G C N+ G F C CA G+ P     +C D+DEC    +     C NT G
Sbjct: 746  NECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPG 805

Query: 2187 SYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGS 2246
            S+ C C +GY L  D + C D+DEC D    C   G +C N  G++ C+CP G R +   
Sbjct: 806  SFQCQCLSGYHLSRDRSHCEDIDEC-DFPAAC--IGGDCINTNGSYRCLCPQGHRLV--G 860

Query: 2247 GEGCTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ----GPCF 2301
            G  C D +EC   P LC+ +G C N  GS+ C CDEGF P+     C ++ Q      C+
Sbjct: 861  GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECY 920

Query: 2302 AEVLQTM-CRSLSSSSEAVTRAECCCGGGRGWGPRCEL--CPLPGTSAYRKLCPHGSGYT 2358
                 T+ C S+ +++  VT+ ECCC  G GWG  CE+  CP+  ++ +  LCP G GYT
Sbjct: 921  LNFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYT 978

Query: 2359 AEG----------RDVDECRML-AHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMD 2407
             +           RD+DEC +  + +C  G+C+N+   + C+C+ G+  D     C+D+D
Sbjct: 979  QDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVD 1038

Query: 2408 ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC---KDLDECTSRQHNC------Q 2458
            EC         +C+NT+G + C+C          R C   ++++    R+  C       
Sbjct: 1039 ECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGED 1098

Query: 2459 FLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPC---GAHGHCHNTPGSFRCECHQ 2515
             +C   +        P  T     C       AQ  PC   GA  HC  +          
Sbjct: 1099 GMCAGPLAG------PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDT 1152

Query: 2516 GFTLVSSGHGCEDVNECDGPH-RCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECA 2573
               L+      ED +E D    RC  G C  + GG  C CP GF   +  A+CVD +EC 
Sbjct: 1153 SPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECR 1212

Query: 2574 ---LSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
                    C S  C NT G FRCVC +GF   +  G C
Sbjct: 1213 ELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250



 Score =  317 bits (812), Expect = 1e-85
 Identities = 217/725 (29%), Positives = 310/725 (42%), Gaps = 129/725 (17%)

Query: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCT 1986
            +T+EC      C  G C      + C C PG++    H  C+D++EC  EP     G C 
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 1987 NSPGSFQCLCPPGFVL--SDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKR 2044
            N+ GS+ C C  G+ L     G  C D  +                          C+K 
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDLNE--------------------------CAKP 667

Query: 2045 PGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTD 2104
               G G  C   P      ++  C  G+          ED++EC + P  C +G C N  
Sbjct: 668  HLCGDGGFCINFPGH----YKCNCYPGYRLKASRPPVCEDIDECRD-PSSCPDGKCENKP 722

Query: 2105 GSFRC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-M 2162
            GSF+C  C  GY     G  C D +EC+ G PC  G C N+ G F C CA G+ P     
Sbjct: 723  GSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGR 781

Query: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222
            +C D+DEC    +     C NT GS+ C C +GY L  D + C D+DEC D    C   G
Sbjct: 782  SCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFPAACI--G 838

Query: 2223 MECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDE 2281
             +C N  G++ C+CP G R +   G  C D +EC   P LC+ +G C N  GS+ C CDE
Sbjct: 839  GDCINTNGSYRCLCPQGHRLV--GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDE 896

Query: 2282 GFQPSPTLTECHDIRQG----PCFAEVLQTM-CRSLSSSSEAVTRAECCCGGGRGWGPRC 2336
            GF P+     C ++ Q      C+     T+ C S+ +++  VT+ ECCC  G GWG  C
Sbjct: 897  GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHC 954

Query: 2337 EL--CPLPGTSAYRKLCPHGSGYTAEG----------RDVDECRML-AHLCAHGECINSL 2383
            E+  CP+  ++ +  LCP G GYT +           RD+DEC +  + +C  G+C+N+ 
Sbjct: 955  EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQ 1014

Query: 2384 GSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRT 2443
              + C+C+ G+  D     C+D+DEC         +C+NT+G + C+C          R 
Sbjct: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074

Query: 2444 C---KDLDECTSRQHNC------QFLCVNTVG--AFT---------------CR-CPPGF 2476
            C   ++++    R+  C        +C   +   A T               CR CPP  
Sbjct: 1075 CLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG 1134

Query: 2477 TQHH---------------------------QACFDNDECSAQPGPCGAHGHCHNTPGSF 2509
               H                            +  D+DEC          G C   PG  
Sbjct: 1135 AGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC------VSGRCVPRPGGA 1188

Query: 2510 RCECHQGFTLVSSGHGCEDVNECDGPHR----CQ-HGCQNQLGGYRCSCPQGFTQHSQWA 2564
             CEC  GF L +S   C D++EC   ++    C+   C N  G +RC C  GF +     
Sbjct: 1189 VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248

Query: 2565 QCVDE 2569
             CV +
Sbjct: 1249 ACVPQ 1253



 Score =  304 bits (778), Expect = 9e-82
 Identities = 262/968 (27%), Positives = 358/968 (36%), Gaps = 208/968 (21%)

Query: 64   FHAYCCPGWRTFPGRSQCVVP------ICRRACG-EGFCSQP-------NLCTCADGTLA 109
            +   C PG    P R+QC+        +C R    E  C  P        LC C      
Sbjct: 377  YRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCC------ 430

Query: 110  PSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCAC 169
             S G + G+ C     +G       C   KGY      Q +  +G  +    + P+    
Sbjct: 431  -SVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPD---- 485

Query: 170  VYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQP 229
                 GP   +     P   Q  P     +  G+     +      +         PA+P
Sbjct: 486  -----GPPKPQQLPESP--SQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARP 538

Query: 230  HP---------CRRGFIPNIHTGACQ---------DVDECQAVPGLCQGGSCVNMVGSFH 271
            +P           R F+P++               + DEC+    +C  G CV     + 
Sbjct: 539  YPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYS 598

Query: 272  CRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVP 331
            C C  G+R       C D           G     +  G Y    C C+RG     G   
Sbjct: 599  CHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYN---CHCNRGYRLHVGAGG 655

Query: 332  ELCPPRGSNEFQQLCAQRLPLL--PGHP--GLFPGLLGFGSNGMGPPLGPARLNPHGSDA 387
              C          LC      +  PGH     +PG   +      PP+            
Sbjct: 656  RSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPG---YRLKASRPPVC----------- 701

Query: 388  RGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRC-ECNVGYTQDVRGE 446
                               + ID CR  ++ C +G+C   P S++C  C  GY     G 
Sbjct: 702  -------------------EDIDECRDPSS-CPDGKCENKPGSFKCIACQPGYRSQGGGA 741

Query: 447  CIDVDECTS-SPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRC 505
            C DV+EC   SPC  G C N+PG++ C C  G+   P  ++C+DVDEC  +G +C  G C
Sbjct: 742  CRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDEC-EAGDVCDNGIC 800

Query: 506  VNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAP 565
             NT GSFQC C +G+ LS D  +C D +EC     C+ G C+N +GS+ CLC  G  L  
Sbjct: 801  SNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV- 859

Query: 566  GGHYCMDIDEC-QTPGICV-NGHCTNTEGSFRCQCLGGLAVGTDGRVCVDT---HVRSTC 620
            GG  C DIDEC Q P +C+ +G C N +GS+ C C  G     D   C +    H +  C
Sbjct: 860  GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKEC 919

Query: 621  YGAIEKGS-CARPFPGTVTKSECCCANPDHGFGEPCQL--CPAKDSAEFQALCSSGLGIT 677
            Y   +    C       VT+ ECCC+    G+G+ C++  CP   SAEF +LC  G G T
Sbjct: 920  YLNFDDTVFCDSVLATNVTQQECCCSL-GAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYT 978

Query: 678  TDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECAL-NSLLCD 736
             D                            + N G  A        D+DEC L  S +C 
Sbjct: 979  QDNN--------------------------IVNYGIPAHR------DIDECMLFGSEICK 1006

Query: 737  NGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLS-SPCVSGVCRNLAGSYTCKCGPGS 795
             G C N+   Y C C  GF++  +   C DVDECL  S C +GVC N  G Y C C P +
Sbjct: 1007 EGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPA 1066

Query: 796  RLDPSGTFCLD--------STKGTCWLKI-QESRCEVNLQGASLR-SECCATLGAAWGSP 845
               P+   CL           +  CW +  ++  C   L G +L   +CC   G  WG+ 
Sbjct: 1067 EYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQ 1126

Query: 846  CE---------------------------------------------------RCEIDPA 854
            C                                                    RC   P 
Sbjct: 1127 CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPG 1186

Query: 855  -----CARGFAR-MTGVTCDDVNECESFPG---VCPNGRCVNTAGSFRCECPEGLMLDAS 905
                 C  GF    +   C D++EC        +C + RCVNT+GSFRC C  G      
Sbjct: 1187 GAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRP 1246

Query: 906  GRLCVDVR 913
               CV  R
Sbjct: 1247 HGACVPQR 1254



 Score =  275 bits (704), Expect = 4e-73
 Identities = 279/1010 (27%), Positives = 359/1010 (35%), Gaps = 223/1010 (22%)

Query: 426  PTPSSYRCECNVGYTQDVRGECIDVDECTS-SPCHHGDCVNIPGTYHCRCYPGFQATPTR 484
            P       +C  GY +     C D++EC     C HGDC+N PG+Y C C PG    P+R
Sbjct: 332  PVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 485  QACV-DVDECIVSGGLCHLGRCVNTEGSFQ-----------CVCNAGFELSPDGKNCVDH 532
              C+ D  E      LC   R V+ E   Q           C C+ G       + C   
Sbjct: 392  TQCIADKPE---EKSLCF--RLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTD 446

Query: 533  NECATSTMCVNGVCLNEDGSFSCLCKPG------FLLAPGGHYCMDIDECQTPGICVNGH 586
               A   +C  G   +   S   L   G      FL   G      + E  +P       
Sbjct: 447  GTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE--SPSQAPPPE 504

Query: 587  CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
             T  E            V TD  V  +  V+ +   A    + ARP+P  +++     + 
Sbjct: 505  DTEEERG----------VTTDSPVSEERSVQQSHPTATT--TPARPYPELISRP----SP 548

Query: 647  PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYR 706
            P   +  P  L P++ + E            T   + +EC L+  +C +G C      Y 
Sbjct: 549  PTMRWFLP-DLPPSRSAVEIAP---------TQVTETDECRLNQNICGHGECVPGPPDYS 598

Query: 707  CVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGF--HFWQDTEIC 764
            C CN GY +    + C DV+EC         G C N+ GSY+C C  G+  H       C
Sbjct: 599  CHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC 658

Query: 765  KDVDECLSSPCV--SGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822
             D++EC         G C N  G Y C C PG RL  S                +   CE
Sbjct: 659  VDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS----------------RPPVCE 702

Query: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDP------ACARGFARMTGVTCDDVNEC-ES 875
             ++      S C          P  +CE  P      AC  G+    G  C DVNEC E 
Sbjct: 703  -DIDECRDPSSC----------PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751

Query: 876  FPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYR 935
             P  C  G C N  GSFRC C +G      GR C+DV         DE E G        
Sbjct: 752  SP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDV---------DECEAG-------- 792

Query: 936  MDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPG 995
             DVC   I       C   P      F   C  G    SRD    R   +D++EC  FP 
Sbjct: 793  -DVCDNGI-------CSNTPG----SFQCQCLSGY-HLSRD----RSHCEDIDECD-FPA 834

Query: 996  LCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTCVNTPGSFECE 1054
             C  G C NT GS+ C C  G  L    R C DIDEC   P LC   G C N  GS+ C 
Sbjct: 835  ACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV 893

Query: 1055 CFPGYESGFMLMKNCMDVD------EC---ARDPLLCRGGTCTN---------------- 1089
            C  G+ +       C +V+      EC     D + C     TN                
Sbjct: 894  CDEGF-TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD 952

Query: 1090 ----------TDGSYKCQCPPGHELTAKGT-------ACEDIDECSL-SDGLCPHGQCVN 1131
                      +   +   CP G   T           A  DIDEC L    +C  G+CVN
Sbjct: 953  HCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVN 1012

Query: 1132 VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG 1191
                ++C C  GF    +   CVD++EC  ++   +  C NT G YRC+C       P  
Sbjct: 1013 TQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQ 1072

Query: 1192 RACADVDECEENPR---VC-----DQGHCTNMPGG-----HRCLCYDGFMATPDMRTC-- 1236
            R C   +E E  P    VC     + G C     G       C C  G       R C  
Sbjct: 1073 RQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPP 1132

Query: 1237 -------------------------------VDVDECDLNPHICLHGDCENTKGSFVCHC 1265
                                            D  E D +   C+ G C    G  VC C
Sbjct: 1133 RGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCEC 1192

Query: 1266 QLGYMVRKGATGCSDVDEC---EVGGHNCDSHASCLNIPGSFSCRCLPGW 1312
              G+ +      C D+DEC      G  C S   C+N  GSF C C  G+
Sbjct: 1193 PGGFQLDASRARCVDIDECRELNQRGLLCKSE-RCVNTSGSFRCVCKAGF 1241



 Score =  267 bits (683), Expect = 1e-70
 Identities = 257/902 (28%), Positives = 346/902 (38%), Gaps = 206/902 (22%)

Query: 1934 LSLAGTCLPGTCQNLEGSFRCICPPGFQ-VQSDHCIDIDECSEEPNLCLFGTCTNSPGSF 1992
            L   G   PG    + G     CP G++ + S HC DI+EC+  P +C  G C N+PGS+
Sbjct: 322  LQYTGVQKPGP---VRGEVGADCPQGYKRLNSTHCQDINECAM-PGVCRHGDCLNNPGSY 377

Query: 1993 QCLCPPGFVLSDNGHRCFDTR---QSFCFTRFEAG-KCSVPKAFNTTKTRCCCSKRPGEG 2048
            +C+CPPG  L  +  +C   +   +S CF       +C  P     T+  CCCS   G+ 
Sbjct: 378  RCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSV--GKA 435

Query: 2049 WGDPC------------ELCPQ---------------EGSAAFQ-----------ELCPF 2070
            WG  C            E+CP                +G + F            +  P 
Sbjct: 436  WGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPE 495

Query: 2071 GHGAVPGPDDSREDVNECAENP-----GVCTNGVCVNTDGS-----------------FR 2108
                 P P+D+ E+     ++P      V  +     T  +                 F 
Sbjct: 496  SPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFL 555

Query: 2109 CECPFGYS-LDFTGINCVDTDECSVGHP-CGQGTCTNVIGGFECACADGFEPGLMMT-CE 2165
             + P   S ++       +TDEC +    CG G C      + C C  G+        C 
Sbjct: 556  PDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCV 615

Query: 2166 DIDECSLNPLLCAFR---CHNTEGSYLCTCPAGYTLR--EDGAMCRDVDECADGQQDCHA 2220
            D++EC   P  C      C NT GSY C C  GY L     G  C D++ECA     C  
Sbjct: 616  DVNECEAEP--CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHL-CGD 672

Query: 2221 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRC-DC 2279
             G  C N  G + C C PG R        C D +EC   P  C +G+C N  GSF+C  C
Sbjct: 673  GGF-CINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIAC 730

Query: 2280 DEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELC 2339
              G++ S     C D+ +           C   S  S              GW   CE  
Sbjct: 731  QPGYR-SQGGGACRDVNE-----------CAEGSPCSP-------------GW---CE-- 760

Query: 2340 PLPGTSAYRKLCPHGSGYTAEGR---DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTP 2396
             LPG+  +R  C  G     +GR   DVDEC     +C +G C N+ GSF+C C +GY  
Sbjct: 761  NLPGS--FRCTCAQGYAPAPDGRSCLDVDECEA-GDVCDNGICSNTPGSFQCQCLSGYHL 817

Query: 2397 DATATTCLDMDECSQVPKPCTFL-CKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQH 2455
                + C D+DEC   P  C    C NT GS+ C CP+G+ L   GR C+D+DEC+    
Sbjct: 818  SRDRSHCEDIDECD-FPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPS 875

Query: 2456 NC--QFLCVNTVGAFTCRCPPGFT--------------QHHQACFDN------------- 2486
             C     C N  G++ C C  GFT               H + C+ N             
Sbjct: 876  LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLAT 935

Query: 2487 ----DECSAQPGPCGAHGHCHNTP------GSFRCECH--QGFT----LVSSGHGCE-DV 2529
                 EC    G  G   HC   P        F   C   +G+T    +V+ G     D+
Sbjct: 936  NVTQQECCCSLG-AGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDI 994

Query: 2530 NECD--GPHRCQHG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRN 2586
            +EC   G   C+ G C N   GY C C QGF       +CVD +EC L    C +  C N
Sbjct: 995  DECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCEN 1053

Query: 2587 TLGGFRCVCPSGFDFDQALGGC---QEVDECAGRRGPC------SYSCANTPGGFL---- 2633
            T GG+RC C    ++  A   C   +E++    RR  C         CA    G      
Sbjct: 1054 TRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFD 1113

Query: 2634 -CGCPQGYF----------RAGQGHCVSGLGFSPGPQDT-------PDKEELLSSEACYE 2675
             C C QG            R    HC +    S    DT       P ++E  S E   E
Sbjct: 1114 DCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDE 1173

Query: 2676 CK 2677
            C+
Sbjct: 1174 CR 1175



 Score =  220 bits (561), Expect = 1e-56
 Identities = 203/734 (27%), Positives = 281/734 (38%), Gaps = 175/734 (23%)

Query: 1404 DVDECAQG-NLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINEC-ADPVNCINGVCI 1461
            + DEC    N+C  G C   P  + C CN GY        C D+NEC A+P     G+C+
Sbjct: 574  ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633

Query: 1462 NTPGSYLCSCPQDFELN--PSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASC 1519
            NT GSY C C + + L+    G  CVD    N   + H  GD G                
Sbjct: 634  NTGGSYNCHCNRGYRLHVGAGGRSCVDL---NECAKPHLCGDGGF--------------- 675

Query: 1520 CCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDC 1579
                       C   P      Y+  C  G   + +R  V  EDIDEC++ P  C  G C
Sbjct: 676  -----------CINFP----GHYKCNCYPGYRLKASRPPVC-EDIDECRD-PSSCPDGKC 718

Query: 1580 VNTFGSFQC-ECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ 1638
             N  GSF+C  C PGY  S+    C D++EC+  S  C PG C N  G++ C C   Y  
Sbjct: 719  ENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGSP-CSPGWCENLPGSFRCTCAQGYAP 776

Query: 1639 VNGGNNCMDMRK----SVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCE---AC 1691
               G +C+D+ +     VC    NG C N       +  C   Y++ +  +  CE    C
Sbjct: 777  APDGRSCLDVDECEAGDVCD---NGICSNTPGS--FQCQCLSGYHLSRDRSH-CEDIDEC 830

Query: 1692 PTPIS----------PDYQILC--GNQAPGFLTDIHTGKPLDIDECGEIPAICA-NGICI 1738
              P +            Y+ LC  G++  G        K  DIDEC + P++C  +G C 
Sbjct: 831  DFPAACIGGDCINTNGSYRCLCPQGHRLVG------GRKCQDIDECSQDPSLCLPHGACK 884

Query: 1739 NQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNAD----CINIPGS----YRCK 1790
            N  GS+ C C  GF        CE+V++   ++  C  N D    C ++  +      C 
Sbjct: 885  NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKE-CYLNFDDTVFCDSVLATNVTQQECC 943

Query: 1791 CTRG--------------------YKLSPGGACVGRNECREIPN---------------- 1814
            C+ G                    + L P G   G  +   I N                
Sbjct: 944  CSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK--GYTQDNNIVNYGIPAHRDIDECMLFG 1001

Query: 1815 --VCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC-DRQPCGNGTCKNIIGSYNCL 1871
              +C  G C++T+  Y C C +GF    +   C+D+DEC D   C NG C+N  G Y C 
Sbjct: 1002 SEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCA 1061

Query: 1872 CFPGFVVT---------------------------HNGDC--------VDFDECTTLVGQ 1896
            C P    +                            +G C        + FD+C    G+
Sbjct: 1062 CTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGR 1121

Query: 1897 ----VCR-------FGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTC 1945
                 CR         HC  +    +        L        D++E  S    C+ G C
Sbjct: 1122 GWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRC 1181

Query: 1946 QNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPN---LCLFGTCTNSPGSFQCLCPPGF 2000
                G   C CP GFQ+ +    C+DIDEC E      LC    C N+ GSF+C+C  GF
Sbjct: 1182 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241

Query: 2001 VLSDNGHRCFDTRQ 2014
              S     C   R+
Sbjct: 1242 ARSRPHGACVPQRR 1255



 Score =  154 bits (389), Expect = 1e-36
 Identities = 177/706 (25%), Positives = 238/706 (33%), Gaps = 208/706 (29%)

Query: 38   EAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFPGR--------SQCVVPICRRA 89
            E  GPGR       GI       G  ++ +C  G+R   G         ++C  P     
Sbjct: 623  EPCGPGR-------GICMNT---GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP---HL 669

Query: 90   CGEG-FCSQ---PNLCTCADGTLAPSCGVSRGSGCSV--SCMNGGTCRGASC-------- 135
            CG+G FC        C C  G    +   SR   C     C +  +C    C        
Sbjct: 670  CGDGGFCINFPGHYKCNCYPGYRLKA---SRPPVCEDIDECRDPSSCPDGKCENKPGSFK 726

Query: 136  --LCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQ-VG 192
               CQ GY     G       C  G  C  P  C  + G     C + Y   P     + 
Sbjct: 727  CIACQPGYRSQGGGACRDVNECAEGSPC-SPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785

Query: 193  PEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQ 252
             + C+    G VC   +C  T G      C+        C  G+  +     C+D+DEC 
Sbjct: 786  VDECE---AGDVCDNGICSNTPG---SFQCQ--------CLSGYHLSRDRSHCEDIDECD 831

Query: 253  AVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA-----------GACFSVLFG 301
              P  C GG C+N  GS+ C CP GHRL      C+D              GAC ++   
Sbjct: 832  -FPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGS 889

Query: 302  GRCAGD-------------------------------------LAGHYTRRQCCCDRGRC 324
              C  D                                     LA + T+++CCC  G  
Sbjct: 890  YVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 949

Query: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG 384
            W        CP   S EF  LC                           P G      + 
Sbjct: 950  WGDHCEIYPCPVYSSAEFHSLC---------------------------PDGKGYTQDNN 982

Query: 385  SDARGIPSLGPGNSNIGTATLNQTIDICRHF-TNLCLNGRCLPTPSSYRCECNVGYTQDV 443
                GIP+             ++ ID C  F + +C  G+C+ T   Y C C  G+  D 
Sbjct: 983  IVNYGIPA-------------HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDG 1029

Query: 444  R-GECIDVDEC-TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDEC-------- 493
               EC+DVDEC   S C +G C N  G Y C C P  + +P ++ C+  +E         
Sbjct: 1030 NLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRD 1089

Query: 494  ----------IVSGGL-----------CHLGRCVNTE---------GSF----QCVCNAG 519
                      + +G L           C  GR    +         GS     Q   N+ 
Sbjct: 1090 VCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSF 1149

Query: 520  FELSP---------DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC 570
            ++ SP         +  +  D +EC     CV+G C+   G   C C  GF L      C
Sbjct: 1150 WDTSPLLLGKPPRDEDSSEEDSDEC----RCVSGRCVPRPGGAVCECPGGFQLDASRARC 1205

Query: 571  MDIDEC----QTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCV 612
            +DIDEC    Q   +C +  C NT GSFRC C  G A       CV
Sbjct: 1206 VDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251



 Score =  108 bits (269), Expect = 1e-22
 Identities = 146/585 (24%), Positives = 190/585 (32%), Gaps = 172/585 (29%)

Query: 19   AWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTFP-G 77
            ++  + C  G + +  GA             SPG  +  N+ GS F   C  G+   P G
Sbjct: 724  SFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCE--NLPGS-FRCTCAQGYAPAPDG 780

Query: 78   RSQCVVPICRRA--CGEGFCSQPN---LCTCADGTLAPS----CGVSRGSGCSVSCMNGG 128
            RS   V  C     C  G CS       C C  G         C          +C+ GG
Sbjct: 781  RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACI-GG 839

Query: 129  TCRGAS----CLCQKGYT---GTVCGQPI--CDRG---CHNGGRCI---GPNRCACVYGF 173
             C   +    CLC +G+    G  C Q I  C +    C   G C    G   C C  GF
Sbjct: 840  DCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898

Query: 174  MGPQ-------CERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
               Q        E+ +    C+           +     T+  CC ++G  WG  CE+ P
Sbjct: 899  TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958

Query: 227  AQPH---------PCRRGF-----IPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGSFH 271
               +         P  +G+     I N    A +D+DEC      +C+ G CVN    + 
Sbjct: 959  CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018

Query: 272  CRCPVGHRLSDSSAACEDY---------RAGACFSVLFG--------------------- 301
            C C  G     +   C D          R G C +   G                     
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSP 1078

Query: 302  --------------------GRCAGDLAG-HYTRRQCCCDRGRCWAAGPVPELCPPRG-- 338
                                G CAG LAG   T   CCC +GR W A   P  CPPRG  
Sbjct: 1079 EEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRP--CPPRGAG 1136

Query: 339  ---------SNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARG 389
                     SN F        PLL G P                        P   D+  
Sbjct: 1137 SHCPTSQSESNSFWDTS----PLLLGKP------------------------PRDEDSS- 1167

Query: 390  IPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDV-RGECI 448
                             +  D CR     C++GRC+P P    CEC  G+  D  R  C+
Sbjct: 1168 ----------------EEDSDECR-----CVSGRCVPRPGGAVCECPGGFQLDASRARCV 1206

Query: 449  DVDECTSSP-----CHHGDCVNIPGTYHCRCYPGFQATPTRQACV 488
            D+DEC         C    CVN  G++ C C  GF  +    ACV
Sbjct: 1207 DIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251



 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 94/335 (28%), Positives = 120/335 (35%), Gaps = 88/335 (26%)

Query: 58  NVCGSR--------FHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLA 109
           N+CG          +  +C PG+R+ P    CV                N C       A
Sbjct: 583 NICGHGECVPGPPDYSCHCNPGYRSHPQHRYCV--------------DVNECE------A 622

Query: 110 PSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTV------------CGQPICDRGCHN 157
             CG  RG      CMN G     +C C +GY   V            C +P     C +
Sbjct: 623 EPCGPGRG-----ICMNTG--GSYNCHCNRGYRLHVGAGGRSCVDLNECAKP---HLCGD 672

Query: 158 GGRCI---GPNRCACVYGF-----MGPQCE-----RDYRT---GPCFGQVGPEGCQHQLT 201
           GG CI   G  +C C  G+       P CE     RD  +   G C  + G   C     
Sbjct: 673 GGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQP 732

Query: 202 GLVCTKALCCATVGR-AWGLPCE--LCPAQPH----PCRRGFIPNIHTGACQDVDECQAV 254
           G        C  V   A G PC    C   P      C +G+ P     +C DVDEC+A 
Sbjct: 733 GYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA- 791

Query: 255 PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTR 314
             +C  G C N  GSF C+C  G+ LS   + CED       +   GG C  +  G Y  
Sbjct: 792 GDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI-NTNGSY-- 848

Query: 315 RQCCCDRGRCWAAG----------PVPELCPPRGS 339
            +C C +G     G            P LC P G+
Sbjct: 849 -RCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGA 882



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 45/122 (36%), Positives = 55/122 (45%), Gaps = 14/122 (11%)

Query: 1019 LDAQERNCTDI------DECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKN--CM 1070
            L  QE  C  I       +C   P L  Q T V  PG    E       G+  + +  C 
Sbjct: 297  LTKQEDCCGSIGTAWGQSKCHKCPQL--QYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQ 354

Query: 1071 DVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC--EDIDECSLSDGL-CPHG 1127
            D++ECA  P +CR G C N  GSY+C CPPGH L    T C  +  +E SL   L  P  
Sbjct: 355  DINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEH 413

Query: 1128 QC 1129
            QC
Sbjct: 414  QC 415



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 36/104 (34%), Positives = 46/104 (44%), Gaps = 19/104 (18%)

Query: 124 CMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYR 183
           C   G CR   CL   G    VC            G  +GP+R  C+        ++   
Sbjct: 359 CAMPGVCRHGDCLNNPGSYRCVCPP----------GHSLGPSRTQCI-------ADKPEE 401

Query: 184 TGPCFGQVGPE-GCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
              CF  V PE  CQH LT  + T+ LCC +VG+AWG  C+ CP
Sbjct: 402 KSLCFRLVSPEHQCQHPLTTRL-TRQLCCCSVGKAWGARCQRCP 444



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 35/118 (29%), Positives = 43/118 (36%), Gaps = 20/118 (16%)

Query: 1122 GLCPHGQCVNVIGAF--QCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRC 1179
            GL     C   IG    Q  CH           C  +    VQ  G         G    
Sbjct: 296  GLTKQEDCCGSIGTAWGQSKCHK----------CPQLQYTGVQKPG------PVRGEVGA 339

Query: 1180 SCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCV 1237
             C QGY  + +   C D++EC   P VC  G C N PG +RC+C  G    P    C+
Sbjct: 340  DCPQGYKRL-NSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 12/93 (12%)

Query: 2526 CEDVNECDGPHRCQHGCQNQLGGYR----------CSCPQGFTQHSQWAQCVDENECALS 2575
            C  +    G  +C    Q Q  G +            CPQG+ + +    C D NECA+ 
Sbjct: 304  CGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS-THCQDINECAM- 361

Query: 2576 PPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
            P  C    C N  G +RCVCP G     +   C
Sbjct: 362  PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 59/201 (29%), Positives = 71/201 (35%), Gaps = 51/201 (25%)

Query: 9   ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC 68
           A G LA LLL    LL + G  GR +G     GP   R  G  G L        RF    
Sbjct: 20  AAGLLALLLLL---LLLLLGLGGRVEG-----GPAGERGAGGGGAL-----ARERFKVVF 66

Query: 69  CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG 128
            P              IC+R C +G C               SC   +GS  ++   NG 
Sbjct: 67  AP-------------VICKRTCLKGQCRD-------------SC--QQGSNMTLIGENG- 97

Query: 129 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF 188
                  L   G+   VC  P     C NGG+C   N+C C   F G  C+     G   
Sbjct: 98  --HSTDTLTGSGFRVVVCPLP-----CMNGGQCSSRNQCLCPPDFTGRFCQ--VPAGGAG 148

Query: 189 GQVGPEGCQHQLTGLVCTKAL 209
           G  G  G     TG + T AL
Sbjct: 149 GGTGGSGPGLSRTGALSTGAL 169



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 47/189 (24%), Positives = 65/189 (34%), Gaps = 43/189 (22%)

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGG-GRGWGP-RCELCPLPGTSAYRKLCPHGS 2355
            G CF + L       S+    +T+ E CCG  G  WG  +C  CP    +  +K  P   
Sbjct: 277  GRCFQDTLPKQPCG-SNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGP--- 332

Query: 2356 GYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKP 2415
                                        G     C  GY     +T C D++EC+ +P  
Sbjct: 333  --------------------------VRGEVGADCPQGYKR-LNSTHCQDINECA-MPGV 364

Query: 2416 CTFL-CKNTKGSFLCSCPRGYLLEEDGRTC-----KDLDEC---TSRQHNCQFLCVNTVG 2466
            C    C N  GS+ C CP G+ L      C     ++   C    S +H CQ      + 
Sbjct: 365  CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLT 424

Query: 2467 AFTCRCPPG 2475
               C C  G
Sbjct: 425  RQLCCCSVG 433



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 3/75 (4%)

Query: 1341 VPGSYRCTCRQGFAG-DGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDH 1399
            V G     C QG+   +   C+D +ECA    +C +G CLN PG YRC C  G       
Sbjct: 333  VRGEVGADCPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391

Query: 1400 RACQDVDECAQGNLC 1414
              C   D+  + +LC
Sbjct: 392  TQC-IADKPEEKSLC 405



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 41/163 (25%), Positives = 61/163 (37%), Gaps = 35/163 (21%)

Query: 2059 EGSAAFQELCPFGHGAVPGPDDSR------EDV---NECAENP--GVCTNGVCVNTDGSF 2107
            E +A  Q L P    + P P   +      +D      C  NP  G+     C  + G+ 
Sbjct: 251  ESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTA 310

Query: 2108 ----RC-ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM 2162
                +C +CP    L +TG+         VG  C QG                ++     
Sbjct: 311  WGQSKCHKCP---QLQYTGVQKPGPVRGEVGADCPQG----------------YKRLNST 351

Query: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC 2205
             C+DI+EC++  +     C N  GSY C CP G++L      C
Sbjct: 352  HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  344 bits (883), Expect = 6e-94
 Identities = 389/1371 (28%), Positives = 525/1371 (38%), Gaps = 293/1371 (21%)

Query: 873  CESFPGVCPNG-RCVNTA-GSFRCECPEGLMLDASGRLCVDVRLEPCF---LRWDEDECG 927
            C SFP  C NG  C++ + G   C+C  G +    G  C     +PC    L  +   C 
Sbjct: 28   CGSFPEPCANGGTCLSLSLGQGTCQCAPGFL----GETCQFP--DPCQNAQLCQNGGSCQ 81

Query: 928  VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDV 987
              LP    +                + P P +  F   C  G       F   R   K  
Sbjct: 82   ALLPAPLGLP---------------SSPSPLTPSFLCTCLPG-------FTGERCQAKLE 119

Query: 988  NECKVFPGLCT-HGTCR-NTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCV 1045
            + C   P  C+  G C     G   C+C  G+  +     C   D C  +P + G G C+
Sbjct: 120  DPCP--PSFCSKRGRCHIQASGRPQCSCMPGWTGE----QCQLRDFCSANPCVNG-GVCL 172

Query: 1046 NTPGSFECECFPGYESGFMLMKNC-MDVDECARDPLLCRGGT-CTNTDGSYKCQCPPGHE 1103
             T    +C C PG+E        C  DV+EC +DP  C  GT C NT GS++C CP G E
Sbjct: 173  ATYPQIQCHCPPGFEG-----HACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQE 227

Query: 1104 LTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQ-----------CSCHAGF-----QST 1147
                G  CE      L  G CP   C N  G  Q           C C  GF     +  
Sbjct: 228  ----GPRCE------LRAGPCPPRGCSNG-GTCQLMPEKDSTFHLCLCPPGFIGPDCEVN 276

Query: 1148 PDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACA-DVDECEEN--P 1204
            PD   CV  ++C  QNGG    C +   +Y C C + ++    G  C+ DVDECE    P
Sbjct: 277  PDN--CVS-HQC--QNGGT---CQDGLDTYTCLCPETWT----GWDCSEDVDECETQGPP 324

Query: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMR--------------TCVD---VDECDLNP- 1246
               + G C N  G   C+C  G+  T                  TC+D      C   P 
Sbjct: 325  HCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPG 384

Query: 1247 ---------HICL----HGDCENTK----GSFVCHCQLGYMVRKGATGCSDVDEC---EV 1286
                      +CL    HGD + +     GS +C CQ GY    G T   D+DEC   + 
Sbjct: 385  RTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGY---SGPTCHQDLDECLMAQQ 441

Query: 1287 GGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYR 1346
            G   C+   SCLN PGSF+C C PG+ G   E  D +EC+SQ   C P   CL++  ++ 
Sbjct: 442  GPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEA-DHNECLSQP--CHPGSTCLDLLATFH 498

Query: 1347 CTCRQGFAGDGFFCE-DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDV 1405
            C C  G   +G  CE + +ECA +    ++  C +   G++C C  GF  T   R  +D+
Sbjct: 499  CLCPPGL--EGQLCEVETNECA-SAPCLNHADCHDLLNGFQCICLPGFSGT---RCEEDI 552

Query: 1406 DECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC-TDINECADPVNCINGVCINTP 1464
            DEC        G C++ PG F C C  G+E    G  C T+++EC      +   C++ P
Sbjct: 553  DECRSSPCANGGQCQDQPGAFHCKCLPGFE----GPRCQTEVDECLSDPCPVGASCLDLP 608

Query: 1465 GSYLCSCPQDFE-------------LNPSGVGCVDTR-AGNCFLETHDRG--DSGISCSA 1508
            G++ C CP  F                P  + C D +   NC       G      +C+ 
Sbjct: 609  GAFFCLCPSGFTGQLCEVPLCAPNLCQPKQI-CKDQKDKANCLCPDGSPGCAPPEDNCTC 667

Query: 1509 EIGVGVTRASCCCSLGRAWGNP-CEL----CPMANTTEYRTLCPGGEGFQ---PNRIT-- 1558
              G    R+SC C +G  W  P CE     C  A      T  P   G+    P   T  
Sbjct: 668  HHG-HCQRSSCVCDVG--WTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGP 724

Query: 1559 VILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGIC-- 1616
               E++  C   P L  GG C  + G + C CPP      HT       +C T +  C  
Sbjct: 725  TCSEEMTACHSGPCL-NGGSCNPSPGGYYCTCPP-----SHTG-----PQCQTSTDYCVS 773

Query: 1617 ----GPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR---HYNGTCQNELAFNV 1669
                  GTC N  G ++C+C   +     G  C    +  C         TCQ+  +   
Sbjct: 774  APCFNGGTCVNRPGTFSCLCAMGF----QGPRCEGKLRPSCADSPCRNRATCQD--SPQG 827

Query: 1670 TRKMCCCSYNIG--QAWNRPCEACPTP-------ISPDYQILC--GNQAPGFLTDIHTGK 1718
             R +C   Y  G  Q     C   P P         P +  LC  G   P     + + +
Sbjct: 828  PRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQ 887

Query: 1719 PLDIDECGEIPAICAN-GICINQIGSFRCECPAGFNYNSILLACED-VDECGSRESPCQQ 1776
               + +  ++ ++C N G+C++   S+ C CP GF  +     C+D V+ C SR  PCQ 
Sbjct: 888  KAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGS----LCQDHVNPCESR--PCQN 941

Query: 1777 NADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGF 1836
             A C+  P  Y C+C  GY    G  C    +  +     +HG C    G + C C  GF
Sbjct: 942  GATCMAQPSGYLCQCAPGY---DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGF 998

Query: 1837 QASADQTLCMDIDECDRQPC---GNGTCKNIIGSYNCLCFPGFVVTHNGDC--VDFDECT 1891
                 +    D+DEC  QPC   G   C ++  ++ C C PG    H G    V+ D C 
Sbjct: 999  VGLRCEG---DVDECLDQPCHPTGTAACHSLANAFYCQCLPG----HTGQWCEVEIDPCH 1051

Query: 1892 TLVGQVC-RFGHCLNTAGS---FHCLCQDGFELTADGKNCVDTNECLSL-----AGTCLP 1942
            +   Q C   G C  TAGS   F C C  GFE    G  C               G CLP
Sbjct: 1052 S---QPCFHGGTCEATAGSPLGFICHCPKGFE----GPTCSHRAPSCGFHHCHHGGLCLP 1104

Query: 1943 GTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLF-GTCTNSPG----SFQCLCP 1997
                      RC C  G+           +    P+ CL+ G+C+ + G     F+C CP
Sbjct: 1105 SPKPGFPP--RCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCP 1162

Query: 1998 PGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWG------- 2050
                 S  G RC       C  R   G C              CS  PG  W        
Sbjct: 1163 H----SSPGPRCQKPGAKGCEGRSGDGACDAG-----------CS-GPGGNWDGGDCSLG 1206

Query: 2051 --DPCELCPQEGSAAFQELCPFGHGAVPGPDDSRE---DVNECAENPGVCT 2096
              DP + CP            F  G      DS E   D  +C E P  CT
Sbjct: 1207 VPDPWKGCPSHSRCWLL----FRDGQCHPQCDSEECLFDGYDC-ETPPACT 1252



 Score =  343 bits (880), Expect = 1e-93
 Identities = 395/1374 (28%), Positives = 523/1374 (38%), Gaps = 320/1374 (23%)

Query: 1406 DECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPG 1465
            + CA G  C   S     G   C C  G+     G  C   + C +   C NG      G
Sbjct: 33   EPCANGGTCLSLSL----GQGTCQCAPGFL----GETCQFPDPCQNAQLCQNG------G 78

Query: 1466 SYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGR 1525
            S     P      P G+    +     FL T   G +G  C A++       S C   GR
Sbjct: 79   SCQALLPA-----PLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLE-DPCPPSFCSKRGR 132

Query: 1526 AWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGS 1585
                 C +   A+     +  PG  G Q        +  D C   P +  GG C+ T+  
Sbjct: 133  -----CHI--QASGRPQCSCMPGWTGEQ-------CQLRDFCSANPCV-NGGVCLATYPQ 177

Query: 1586 FQCECPPGYHLSEHTRICE-DIDECSTHSGICGPGT-CYNTLGNYTCVCPAEYLQVNGGN 1643
             QC CPPG+        CE D++EC    G C  GT C+NTLG++ C+CP        G 
Sbjct: 178  IQCHCPPGFE----GHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG----QEGP 229

Query: 1644 NCMDMRKSVCFRH---YNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQ 1700
             C ++R   C        GTCQ     + T  +C C               P  I PD +
Sbjct: 230  RC-ELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCP--------------PGFIGPDCE 274

Query: 1701 ILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANG-ICINQIGSFRCECPAGFNYNSILL 1759
            +                   + D C  +   C NG  C + + ++ C CP  +       
Sbjct: 275  V-------------------NPDNC--VSHQCQNGGTCQDGLDTYTCLCPETWTGWD--- 310

Query: 1760 ACEDVDECGSRESP-CQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSH 1818
              EDVDEC ++  P C+    C N  GS+ C C  G+    GG     N    I   C+ 
Sbjct: 311  CSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGW----GGTSCEENLDDCIAATCAP 366

Query: 1819 GD-CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPC-GNGTCKN--IIGSYNCLCFP 1874
            G  C+D  GS+ CLC  G        LC   D C  QPC G+  C    + GS  CLC P
Sbjct: 367  GSTCIDRVGSFSCLCPPGRTG----LLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQP 422

Query: 1875 GFV--VTHNGDCVDFDECTTLVGQV----CRFG-HCLNTAGSFHCLCQDGFELTADGKNC 1927
            G+     H     D DEC  L+ Q     C  G  CLNT GSF+CLC  G+     G  C
Sbjct: 423  GYSGPTCHQ----DLDEC--LMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYT----GSRC 472

Query: 1928 -VDTNECLSLAGTCLPG-TCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCL-FGT 1984
              D NECLS    C PG TC +L  +F C+CPPG + Q    ++ +EC+  P  CL    
Sbjct: 473  EADHNECLSQP--CHPGSTCLDLLATFHCLCPPGLEGQLCE-VETNECASAP--CLNHAD 527

Query: 1985 CTNSPGSFQCLCPPGFVLSDNGHRCFDT----RQSFCFTRFEAGKCS-VPKAFNTTKTRC 2039
            C +    FQC+C PGF    +G RC +     R S C      G+C   P AF+    +C
Sbjct: 528  CHDLLNGFQCICLPGF----SGTRCEEDIDECRSSPCAN---GGQCQDQPGAFHC---KC 577

Query: 2040 C-------CSKRPGEGWGDPCELCPQ--EGSAAFQELCPFGHGAVPGPDDSREDVNECAE 2090
                    C     E   DPC +     +   AF  LCP G            +V  CA 
Sbjct: 578  LPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTG------QLCEVPLCA- 630

Query: 2091 NPGVCT-NGVCVNTDGSFRCECPFGYSLDFTGINCVDTDE---CSVGHPCGQGTCTNVIG 2146
             P +C    +C +      C CP G         C   ++   C  GH C + +C   +G
Sbjct: 631  -PNLCQPKQICKDQKDKANCLCPDGSP------GCAPPEDNCTCHHGH-CQRSSCVCDVG 682

Query: 2147 --GFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAM 2204
              G EC               ++  C   P      C+     Y CTCP GYT       
Sbjct: 683  WTGPECEA-------------ELGGCISAPCAHGGTCYPQPSGYNCTCPTGYT------- 722

Query: 2205 CRDVDECADGQQDCHA----RGMECKNLIGTFACVCPPGMRPLPGSGEGC-TDDNECHAQ 2259
                  C++    CH+     G  C    G + C CPP       +G  C T  + C + 
Sbjct: 723  ---GPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSH-----TGPQCQTSTDYCVSA 774

Query: 2260 PDLCVNG-RCVNTAGSFRCDCDEGFQ---------------PSPTLTECHDIRQGP---C 2300
            P  C NG  CVN  G+F C C  GFQ               P      C D  QGP   C
Sbjct: 775  P--CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLC 832

Query: 2301 FAEVLQTMCRSLSS--SSEAVTRAECCCGGG--------RGW-GPRCELCPLPGTSAYRK 2349
                    C++L    + +   R   C   G        +GW GP   LC LP +S  + 
Sbjct: 833  PTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGP---LCNLPLSSCQKA 889

Query: 2350 LCPHGSGYTAEGRDVDECRMLAHLCAHGE-CINSLGSFRCHCQAGYTPDATATTCLD-MD 2407
                     ++G DV        LC +G  C++S  S+ CHC  G+      + C D ++
Sbjct: 890  AL-------SQGIDVSS------LCHNGGLCVDSGPSYFCHCPPGFQ----GSLCQDHVN 932

Query: 2408 ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC-KDLDECTSRQHNCQFLCVNTVG 2466
             C   P      C      +LC C  GY    DG+ C K+LD C S+  +    C    G
Sbjct: 933  PCESRPCQNGATCMAQPSGYLCQCAPGY----DGQNCSKELDACQSQPCHNHGTCTPKPG 988

Query: 2467 AFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGC 2526
             F C CPPGF    +   D DEC  QP        CH+   +F C+C  G T    G  C
Sbjct: 989  GFHCACPPGFV-GLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHT----GQWC 1043

Query: 2527 E-DVNECDGPHRCQHG--CQNQLG---GYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2580
            E +++ C     C HG  C+   G   G+ C CP+GF          +   C+   P+CG
Sbjct: 1044 EVEIDPCHS-QPCFHGGTCEATAGSPLGFICHCPKGF----------EGPTCSHRAPSCG 1092

Query: 2581 SASCRNTLGGF-----------RCVCPSGFDFDQALGGCQEVDECAGRRGPCSY--SCAN 2627
               C +  GG            RC C SG+     L       +  G   PC Y  SC+ 
Sbjct: 1093 FHHCHH--GGLCLPSPKPGFPPRCACLSGYGGPDCL--TPPAPKGCGPPSPCLYNGSCSE 1148

Query: 2628 TPG----GFLCGCPQG--------------YFRAGQGHCVSGLGFSPGPQDTPD 2663
            T G    GF C CP                  R+G G C +G     G  D  D
Sbjct: 1149 TTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGD 1202



 Score =  294 bits (753), Expect = 7e-79
 Identities = 354/1297 (27%), Positives = 489/1297 (37%), Gaps = 246/1297 (18%)

Query: 100  LCTCADGTLAPSCGVSRGSGCSVS-CMNGGTCR-----GASCLCQKGYTGTVCG-QPICD 152
            LCTC  G     C       C  S C   G C         C C  G+TG  C  +  C 
Sbjct: 102  LCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCS 161

Query: 153  RG-CHNGGRCIGPN---RCACVYGFMGPQCERDYRTGPCFGQVGP----EGCQHQLTGLV 204
               C NGG C+      +C C  GF G  CERD     CF   GP      C + L    
Sbjct: 162  ANPCVNGGVCLATYPQIQCHCPPGFEGHACERD--VNECFQDPGPCPKGTSCHNTLGSFQ 219

Query: 205  C------------TKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQ 252
            C             +A  C   G + G  C+L P +         P    G   +V+   
Sbjct: 220  CLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDN 279

Query: 253  AVPGLCQ-GGSCVNMVGSFHCRCP---VGHRLSDSSAACEDYRAGACFSVLFGGRCAGDL 308
             V   CQ GG+C + + ++ C CP    G   S+    CE      C +   GG C    
Sbjct: 280  CVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRN---GGTCQNS- 335

Query: 309  AGHYTRRQCCCDRGRCWAAGPVPE--------LCPPRGSNEFQQLCAQRLPLLPGHPGLF 360
            AG +    C C  G  W      E         C P GS    ++ +      PG  GL 
Sbjct: 336  AGSF---HCVCVSG--WGGTSCEENLDDCIAATCAP-GSTCIDRVGSFSCLCPPGRTGLL 389

Query: 361  PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDIC---RHFTN 417
              L     +   P  G A+ + +      +    PG S     T +Q +D C   +   +
Sbjct: 390  CHLEDMCLS--QPCHGDAQCSTNPLTGSTLCLCQPGYSG---PTCHQDLDECLMAQQGPS 444

Query: 418  LCLN-GRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD-CVNIPGTYHCRCY 475
             C + G CL TP S+ C C  GYT   R E  D +EC S PCH G  C+++  T+HC C 
Sbjct: 445  PCEHGGSCLNTPGSFNCLCPPGYTGS-RCEA-DHNECLSQPCHPGSTCLDLLATFHCLCP 502

Query: 476  PGFQATPTRQAC-VDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHN 533
            PG +     Q C V+ +EC  +  L H   C +    FQC+C  GF     G  C  D +
Sbjct: 503  PGLEG----QLCEVETNECASAPCLNH-ADCHDLLNGFQCICLPGF----SGTRCEEDID 553

Query: 534  ECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGS 593
            EC +S     G C ++ G+F C C PGF    G     ++DEC +    V   C +  G+
Sbjct: 554  ECRSSPCANGGQCQDQPGAFHCKCLPGF---EGPRCQTEVDECLSDPCPVGASCLDLPGA 610

Query: 594  FRCQCLGGLAVGTDGRVC-VDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFG 652
            F C C  G      G++C V     + C     K  C         K+ C C +   G  
Sbjct: 611  FFCLCPSGFT----GQLCEVPLCAPNLCQ---PKQIC----KDQKDKANCLCPDGSPGCA 659

Query: 653  EPCQLCPAKDSAEFQALCSSGLGITTD--GRDINECALDPEVCAN-GVCENLRGSYRCVC 709
             P   C        ++ C   +G T      ++  C   P  CA+ G C      Y C C
Sbjct: 660  PPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAP--CAHGGTCYPQPSGYNCTC 717

Query: 710  NLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
              GY    +G  C++      +    + G C  SPG Y C+CPP        +     D 
Sbjct: 718  PTGY----TGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSH---TGPQCQTSTDY 770

Query: 770  CLSSPCVS-GVCRNLAGSYTCKCGPG-------SRLDPSGTFCLDS---TKGTCWLKIQE 818
            C+S+PC + G C N  G+++C C  G        +L PS   C DS    + TC    Q 
Sbjct: 771  CVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPS---CADSPCRNRATCQDSPQG 827

Query: 819  SR--CEVNLQGASLRS--ECCATLGAAWGSPCERC--EIDPACARGFARMTGVTCD-DVN 871
             R  C     G S ++  + CA       S C +        C +G+   TG  C+  ++
Sbjct: 828  PRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGW---TGPLCNLPLS 884

Query: 872  ECE--------SFPGVCPN-GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWD 922
             C+            +C N G CV++  S+ C CP G      G LC D  + PC  R  
Sbjct: 885  SCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGF----QGSLCQD-HVNPCESR-- 937

Query: 923  EDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRP 982
                              C  GA     C A P         LC    G+       G+ 
Sbjct: 938  -----------------PCQNGAT----CMAQPS------GYLCQCAPGY------DGQN 964

Query: 983  FYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISP-DLCGQ 1041
              K+++ C+  P    HGTC    G FHCAC  GF      R   D+DEC   P    G 
Sbjct: 965  CSKELDACQSQP-CHNHGTCTPKPGGFHCACPPGF---VGLRCEGDVDECLDQPCHPTGT 1020

Query: 1042 GTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGS---YKCQC 1098
              C +   +F C+C PG+   +      +++D C   P    GGTC  T GS   + C C
Sbjct: 1021 AACHSLANAFYCQCLPGHTGQWCE----VEIDPCHSQPCF-HGGTCEATAGSPLGFICHC 1075

Query: 1099 PPGHELTAKGTACED-IDECSLSDGLCPH-GQCV-NVIGAF--QCSCHAGF-----QSTP 1148
            P G E    G  C      C      C H G C+ +    F  +C+C +G+      + P
Sbjct: 1076 PKGFE----GPTCSHRAPSCGFHH--CHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPP 1129

Query: 1149 DRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQG----YSLMPDGRACADVDECEENP 1204
              +GC   + C + NG C          +RCSC           P  + C    E     
Sbjct: 1130 APKGCGPPSPC-LYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGC----EGRSGD 1184

Query: 1205 RVCDQGHCTNMPGGHRCLCYDG---FMATPD-MRTCVDVDECDLNPHICLHGDCENTKGS 1260
              CD G C+  PGG+    +DG    +  PD  + C     C L     L  D +     
Sbjct: 1185 GACDAG-CSG-PGGN----WDGGDCSLGVPDPWKGCPSHSRCWL-----LFRDGQ----- 1228

Query: 1261 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASC 1297
              CH Q             D +EC   G++C++  +C
Sbjct: 1229 --CHPQ------------CDSEECLFDGYDCETPPAC 1251



 Score =  292 bits (747), Expect = 4e-78
 Identities = 298/1054 (28%), Positives = 398/1054 (37%), Gaps = 221/1054 (20%)

Query: 1725 CGEIPAICAN-GICIN-QIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADC-- 1780
            CG  P  CAN G C++  +G   C+C  GF    +   C+  D C + +  CQ    C  
Sbjct: 28   CGSFPEPCANGGTCLSLSLGQGTCQCAPGF----LGETCQFPDPCQNAQL-CQNGGSCQA 82

Query: 1781 -----INIPG-------SYRCKCTRGYKLSPGGACVGRNECREIPNVCS-HGDC-MDTEG 1826
                 + +P        S+ C C  G+    G  C  + E    P+ CS  G C +   G
Sbjct: 83   LLPAPLGLPSSPSPLTPSFLCTCLPGF---TGERCQAKLEDPCPPSFCSKRGRCHIQASG 139

Query: 1827 SYMCLCHRGFQASADQTLCMDIDECDRQPCGN-GTCKNIIGSYNCLCFPGFVVTHNGDCV 1885
               C C  G+        C   D C   PC N G C        C C PGF       C 
Sbjct: 140  RPQCSCMPGWTGEQ----CQLRDFCSANPCVNGGVCLATYPQIQCHCPPGF---EGHACE 192

Query: 1886 -DFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLP-- 1942
             D +EC    G   +   C NT GSF CLC  G E             C   AG C P  
Sbjct: 193  RDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQE----------GPRCELRAGPCPPRG 242

Query: 1943 ----GTCQNL---EGSFR-CICPPGF-----QVQSDHCI--------------------- 1968
                GTCQ +   + +F  C+CPPGF     +V  D+C+                     
Sbjct: 243  CSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLC 302

Query: 1969 -----------DIDECSEE--PNLCLFGTCTNSPGSFQCLCPPGF---VLSDNGHRCFDT 2012
                       D+DEC  +  P+    GTC NS GSF C+C  G+      +N   C   
Sbjct: 303  PETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAA 362

Query: 2013 R---QSFCFTRFEAGKCSVPKAFNTTKTRC----CCSKRPGEGWGDPCELCPQEGSAAFQ 2065
                 S C  R  +  C  P     T   C     C  +P  G    C   P  GS    
Sbjct: 363  TCAPGSTCIDRVGSFSCLCPP--GRTGLLCHLEDMCLSQPCHG-DAQCSTNPLTGSTLC- 418

Query: 2066 ELCPFGHGAVPGPDDSREDVNEC---AENPGVCTN-GVCVNTDGSFRCECPFGYSLDFTG 2121
             LC  G+    GP    +D++EC    + P  C + G C+NT GSF C CP GY    TG
Sbjct: 419  -LCQPGYS---GP-TCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY----TG 469

Query: 2122 INC-VDTDECSVGHPCGQG-TCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNPLLCA 2178
              C  D +EC +  PC  G TC +++  F C C  G E  L   CE + +EC+  P L  
Sbjct: 470  SRCEADHNEC-LSQPCHPGSTCLDLLATFHCLCPPGLEGQL---CEVETNECASAPCLNH 525

Query: 2179 FRCHNTEGSYLCTCPAGYTLREDGAMC-RDVDECADGQQDCHARGMECKNLIGTFACVCP 2237
              CH+    + C C  G++    G  C  D+DEC      C A G +C++  G F C C 
Sbjct: 526  ADCHDLLNGFQCICLPGFS----GTRCEEDIDECR--SSPC-ANGGQCQDQPGAFHCKCL 578

Query: 2238 PGMRPLPGSGEGC-TDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296
            PG       G  C T+ +EC + P   V   C++  G+F C C  GF           + 
Sbjct: 579  PGF-----EGPRCQTEVDECLSDP-CPVGASCLDLPGAFFCLCPSGF--------TGQLC 624

Query: 2297 QGPCFAEVLQTMCRSLSSSSEAVTRAECCC-GGGRGWGPRCELCPLPGTSAYRKLCPHGS 2355
            + P  A     +C+      +   +A C C  G  G  P  + C        R  C    
Sbjct: 625  EVPLCA---PNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDV 681

Query: 2356 GYTAEGRDVDECRMLAHLCAH-GECINSLGSFRCHCQAGYTPDATATTCL-DMDECSQVP 2413
            G+T    + +    ++  CAH G C      + C C  GY    T  TC  +M  C   P
Sbjct: 682  GWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGY----TGPTCSEEMTACHSGP 737

Query: 2414 KPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCK-DLDECTSRQHNCQFLCVNTVGAFTCRC 2472
                  C  + G + C+CP  +     G  C+   D C S        CVN  G F+C C
Sbjct: 738  CLNGGSCNPSPGGYYCTCPPSH----TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLC 793

Query: 2473 PPGF-----------------TQHHQACFDNDE---CSAQPG----------------PC 2496
              GF                  ++   C D+ +   C    G                PC
Sbjct: 794  AMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPC 853

Query: 2497 GAHGHCHNTPGSFRCECHQGFT------LVSSGHGCEDVNECDGPHRCQHG--CQNQLGG 2548
              + HC  T  SF C C QG+T       +SS          D    C +G  C +    
Sbjct: 854  PRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPS 913

Query: 2549 YRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
            Y C CP GF    Q + C D      S P    A+C     G+ C C  G+D        
Sbjct: 914  YFCHCPPGF----QGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNC---S 966

Query: 2609 QEVDECAGRRGPCSY--SCANTPGGFLCGCPQGY 2640
            +E+D C  +  PC    +C   PGGF C CP G+
Sbjct: 967  KELDACQSQ--PCHNHGTCTPKPGGFHCACPPGF 998



 Score =  278 bits (710), Expect = 7e-74
 Identities = 380/1413 (26%), Positives = 498/1413 (35%), Gaps = 408/1413 (28%)

Query: 124  CMNGGTCRGAS-----CLCQKGYTGTVCGQPI-CDRG--CHNGGRC-------------- 161
            C NGGTC   S     C C  G+ G  C  P  C     C NGG C              
Sbjct: 35   CANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSP 94

Query: 162  --IGPN-RCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAW 218
              + P+  C C+ GF G +C+      PC                 C+K   C    +A 
Sbjct: 95   SPLTPSFLCTCLPGFTGERCQAKLED-PC-------------PPSFCSKRGRCHI--QAS 138

Query: 219  GLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGH 278
            G P   C           +P      CQ  D C A P +  GG C+       C CP G 
Sbjct: 139  GRPQCSC-----------MPGWTGEQCQLRDFCSANPCV-NGGVCLATYPQIQCHCPPGF 186

Query: 279  RLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR--QCCCDRGRCWAAGPVPEL--- 333
                   ACE      CF     G C    + H T    QC C  G+    GP  EL   
Sbjct: 187  E----GHACER-DVNECFQD--PGPCPKGTSCHNTLGSFQCLCPVGQ---EGPRCELRAG 236

Query: 334  -CPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPP--LGP-ARLNPHGSDARG 389
             CPPRG +           L+P     F   L        PP  +GP   +NP       
Sbjct: 237  PCPPRGCSN-----GGTCQLMPEKDSTFHLCLC-------PPGFIGPDCEVNP------- 277

Query: 390  IPSLGPGNSNIGTATLNQTIDICRHFTNLCLNG-RCLPTPSSYRCECNVGYTQDVRGECI 448
                                D C   ++ C NG  C     +Y C C   +T     E  
Sbjct: 278  --------------------DNC--VSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSE-- 313

Query: 449  DVDEC-TSSPCH---HGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR 504
            DVDEC T  P H    G C N  G++HC C  G+  T   +   ++D+CI +   C  G 
Sbjct: 314  DVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEE---NLDDCIAA--TCAPGS 368

Query: 505  -CVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNE--------DGSFSC 555
             C++  GSF C+C       P G+  +    C    MC++  C  +         GS  C
Sbjct: 369  TCIDRVGSFSCLC-------PPGRTGL---LCHLEDMCLSQPCHGDAQCSTNPLTGSTLC 418

Query: 556  LCKPGFLLAPGGHYC-MDIDEC----QTPGICVNG-HCTNTEGSFRCQCLGGLAVGTDGR 609
            LC+PG+     G  C  D+DEC    Q P  C +G  C NT GSF C C  G      G 
Sbjct: 419  LCQPGY----SGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYT----GS 470

Query: 610  VCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQAL 669
             C   H                           C + P H       L      A F  L
Sbjct: 471  RCEADHNE-------------------------CLSQPCHPGSTCLDLL-----ATFHCL 500

Query: 670  CSSGLGITTDGRDINECALDPEVCANGV-CENLRGSYRCVCNLGYEAGASGKDCT-DVDE 727
            C  GL       + NECA  P  C N   C +L   ++C+C  G+    SG  C  D+DE
Sbjct: 501  CPPGLEGQLCEVETNECASAP--CLNHADCHDLLNGFQCICLPGF----SGTRCEEDIDE 554

Query: 728  CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPC-VSGVCRNLAGS 786
            C  +S   + G CQ+ PG++ C C PGF   +      +VDECLS PC V   C +L G+
Sbjct: 555  CR-SSPCANGGQCQDQPGAFHCKCLPGF---EGPRCQTEVDECLSDPCPVGASCLDLPGA 610

Query: 787  YTCKCGPG-----------------------SRLDPSGTFCLDSTKG--------TC--- 812
            + C C  G                        + D +   C D + G        TC   
Sbjct: 611  FFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHG 670

Query: 813  WLKIQESRCEVNLQGASLRSECCATLGAAWGSPCER---CEIDPA-----CARGFARMTG 864
              +     C+V   G     EC A LG    +PC     C   P+     C  G+   TG
Sbjct: 671  HCQRSSCVCDVGWTG----PECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGY---TG 723

Query: 865  VTC-DDVNECESFPGVCPN-GRCVNTAGSFRCECP---EGLMLDASGRLCVDVRLEPCFL 919
             TC +++  C S  G C N G C  + G + C CP    G     S   CV     PCF 
Sbjct: 724  PTCSEEMTACHS--GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSA---PCF- 777

Query: 920  RWDEDECGVTLPGKYRMDVCCCSIGAVWGVECE-----ACPDPESLEFAS---------- 964
              +   C V  PG +    C C++G   G  CE     +C D      A+          
Sbjct: 778  --NGGTC-VNRPGTFS---CLCAMG-FQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRC 830

Query: 965  LCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCT------HGTCRNTVGSFHCACAGGFA 1018
            LCP G    S               C+    LC       +  C  T  SFHC C  G+ 
Sbjct: 831  LCPTGYTGGS---------------CQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWT 875

Query: 1019 LDAQERNCTDIDECRIS-----PDLC-GQGTCVNTPGSFECECFPGYESGFMLMKNCMD- 1071
                    +   +  +S       LC   G CV++  S+ C C PG++        C D 
Sbjct: 876  GPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSL-----CQDH 930

Query: 1072 VDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC-EDIDECSLSDGLCPHGQCV 1130
            V+ C   P    G TC      Y CQC PG++    G  C +++D C  S     HG C 
Sbjct: 931  VNPCESRPCQ-NGATCMAQPSGYLCQCAPGYD----GQNCSKELDACQ-SQPCHNHGTCT 984

Query: 1131 NVIGAFQCSCHAGFQSTPDRQGCVDINECRVQ--NGGCDVHCINTEGSYRCSCGQGYSLM 1188
               G F C+C  GF          D++EC  Q  +      C +   ++ C C  G++  
Sbjct: 985  PKPGGFHCACPPGFVGLRCEG---DVDECLDQPCHPTGTAACHSLANAFYCQCLPGHT-- 1039

Query: 1189 PDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPH 1247
              G+ C  ++D C   P                  C+ G                     
Sbjct: 1040 --GQWCEVEIDPCHSQP------------------CFHG--------------------- 1058

Query: 1248 ICLHGDCENTKGS---FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSF 1304
                G CE T GS   F+CHC  G+   +G T       C  G H+C     CL  P   
Sbjct: 1059 ----GTCEATAGSPLGFICHCPKGF---EGPTCSHRAPSC--GFHHCHHGGLCLPSPKPG 1109

Query: 1305 ---SCRCLPGWVGDGFECHDLDECVS--QEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFF 1359
                C CL G+ G         +C++      C P   CL   GS  C+   G  G GF 
Sbjct: 1110 FPPRCACLSGYGG--------PDCLTPPAPKGCGPPSPCL-YNGS--CSETTGLGGPGFR 1158

Query: 1360 CEDRDECAENVDLCDNGQCLNAPGGYRCECEMG 1392
            C     C  +      G     PG   CE   G
Sbjct: 1159 C----SCPHS----SPGPRCQKPGAKGCEGRSG 1183



 Score =  210 bits (535), Expect = 1e-53
 Identities = 311/1217 (25%), Positives = 425/1217 (34%), Gaps = 273/1217 (22%)

Query: 69   CPGWRTFPGRSQCVVPICRRACGEGFCSQP--------NLCTCADGTLAPSCGVSRGSGC 120
            CP  +  P       P   R C  G   Q         +LC C  G + P C V+  +  
Sbjct: 222  CPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCV 281

Query: 121  SVSCMNGGTCRGA----SCLCQKGYTGTVCGQPI--CDR----GCHNGGRC---IGPNRC 167
            S  C NGGTC+      +CLC + +TG  C + +  C+      C NGG C    G   C
Sbjct: 282  SHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHC 341

Query: 168  ACVYGFMGPQCERDYRT---------GPCFGQVGPEG--CQHQLTGLVCTKALCCATVGR 216
             CV G+ G  CE +              C  +VG     C    TGL+C     C +   
Sbjct: 342  VCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPC 401

Query: 217  AWGLPCELCPAQPHP---CRRGFI-PNIHTGACQDVDEC---QAVPGLCQ-GGSCVNMVG 268
                 C   P        C+ G+  P  H    QD+DEC   Q  P  C+ GGSC+N  G
Sbjct: 402  HGDAQCSTNPLTGSTLCLCQPGYSGPTCH----QDLDECLMAQQGPSPCEHGGSCLNTPG 457

Query: 269  SFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAG 328
            SF+C CP G+  S   A   +  +  C     G  C   LA  +    C C        G
Sbjct: 458  SFNCLCPPGYTGSRCEADHNECLSQPCHP---GSTCLDLLATFH----CLC------PPG 504

Query: 329  PVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDAR 388
               +LC    +NE    CA   P L  H      L GF    +                 
Sbjct: 505  LEGQLCEVE-TNE----CAS-APCL-NHADCHDLLNGFQCICL----------------- 540

Query: 389  GIPSLGPGNSNIGTATLNQTIDICRHFTNLCLN-GRCLPTPSSYRCECNVGYTQDVRGEC 447
                  PG S        + ID CR  ++ C N G+C   P ++ C+C  G+ +  R + 
Sbjct: 541  ------PGFSG---TRCEEDIDECR--SSPCANGGQCQDQPGAFHCKCLPGF-EGPRCQ- 587

Query: 448  IDVDECTSSPCHHG-DCVNIPGTYHCRCYPGF------------QATPTRQACVDVDE-- 492
             +VDEC S PC  G  C+++PG + C C  GF                 +Q C D  +  
Sbjct: 588  TEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKA 647

Query: 493  -CIVSGG-----------LCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATST 539
             C+   G            CH G C  +     CVC+ G+     G  C  +   C ++ 
Sbjct: 648  NCLCPDGSPGCAPPEDNCTCHHGHCQRS----SCVCDVGW----TGPECEAELGGCISAP 699

Query: 540  MCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVN-GHCTNTEGSFRCQC 598
                G C  +   ++C C  G+     G  C +       G C+N G C  + G + C C
Sbjct: 700  CAHGGTCYPQPSGYNCTCPTGYT----GPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTC 755

Query: 599  LGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEP---- 654
                  G   +   D  V + C+     G+C    PGT +   C CA    GF  P    
Sbjct: 756  PPS-HTGPQCQTSTDYCVSAPCFNG---GTCVNR-PGTFS---CLCA---MGFQGPRCEG 804

Query: 655  -----CQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCA------NGVCENLRG 703
                 C   P ++ A  Q        +   G     C    ++CA      N  C     
Sbjct: 805  KLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGP 864

Query: 704  SYRCVCNLGYEAGASGKDCTDVDECALN-----SLLCDN-GWCQNSPGSYSCSCPPGFHF 757
            S+ C+C  G+         +   + AL+     S LC N G C +S  SY C CPPGF  
Sbjct: 865  SFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGF-- 922

Query: 758  WQDTEICKD-VDECLSSPCVSG-VCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLK 815
                 +C+D V+ C S PC +G  C      Y C+C PG                     
Sbjct: 923  --QGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPG--------------------- 959

Query: 816  IQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNECE 874
                 C   L   + +S+ C   G     P        AC  GF    G+ C+ DV+EC 
Sbjct: 960  YDGQNCSKELD--ACQSQPCHNHGTCTPKP---GGFHCACPPGF---VGLRCEGDVDECL 1011

Query: 875  SFPGVCPNG--RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPG 932
              P   P G   C + A +F C+C  G     +G+ C +V ++PC               
Sbjct: 1012 DQP-CHPTGTAACHSLANAFYCQCLPG----HTGQWC-EVEIDPCH-------------- 1051

Query: 933  KYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKV 992
                     S     G  CEA      L F   CP+G         S R      + C  
Sbjct: 1052 ---------SQPCFHGGTCEATAG-SPLGFICHCPKGF---EGPTCSHRAPSCGFHHCH- 1097

Query: 993  FPGLCTHGTCRNTVGSFHCACAGGFA-----LDAQERNCTDIDECRISPDLCGQGTCVNT 1047
              GLC             CAC  G+           + C     C  +   C + T +  
Sbjct: 1098 HGGLCLPSPKPGFPP--RCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGS-CSETTGLGG 1154

Query: 1048 PGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYK-CQCPPGHELTA 1106
            PG F C C P    G    K      E       C  G C+   G++    C  G     
Sbjct: 1155 PG-FRCSC-PHSSPGPRCQKPGAKGCEGRSGDGACDAG-CSGPGGNWDGGDCSLGVPDPW 1211

Query: 1107 KGTACEDIDECSL--SDGLCPHGQCVN---VIGAFQCS------------CHAGFQSTPD 1149
            KG  C     C L   DG C H QC +   +   + C             CH  F +   
Sbjct: 1212 KG--CPSHSRCWLLFRDGQC-HPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHC 1268

Query: 1150 RQGCVDINECRVQNGGC 1166
             +GC +  EC    G C
Sbjct: 1269 EKGC-NTAECGWDGGDC 1284



 Score =  164 bits (414), Expect = 1e-39
 Identities = 233/925 (25%), Positives = 308/925 (33%), Gaps = 230/925 (24%)

Query: 55   QGPNVC---GS------RFHAYCCPGW---RTFPGRSQCVVPICRRACGEGFCSQPNLCT 102
            QGP+ C   GS       F+  C PG+   R     ++C+   C              C 
Sbjct: 441  QGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCL 500

Query: 103  CADGTLAPSCGVSRGSGCSVSCMNGGTCR----GASCLCQKGYTGTVCGQPICD---RGC 155
            C  G     C V      S  C+N   C     G  C+C  G++GT C + I +     C
Sbjct: 501  CPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPC 560

Query: 156  HNGGRC---IGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG-------------CQHQ 199
             NGG+C    G   C C+ GF GP+C+ +     C     P G             C   
Sbjct: 561  ANGGQCQDQPGAFHCKCLPGFEGPRCQTE--VDECLSDPCPVGASCLDLPGAFFCLCPSG 618

Query: 200  LTGLVCTKALCCATVGRAWGLPCELCPAQPHPCR-------RGFIP-----NIHTGACQ- 246
             TG +C   LC   + +    P ++C  Q             G  P       H G CQ 
Sbjct: 619  FTGQLCEVPLCAPNLCQ----PKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQR 674

Query: 247  -----DV----DECQAVPGLC------QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
                 DV     EC+A  G C       GG+C      ++C CP G+     S       
Sbjct: 675  SSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACH 734

Query: 292  AGACFSVLFGGRCAGDLAGHY-------TRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
            +G C   L GG C     G+Y       T  QC      C +A      C   G+     
Sbjct: 735  SGPC---LNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAP-----CFNGGT----- 781

Query: 345  LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
             C  R       PG F  L   G  G   P    +L P  +D+                 
Sbjct: 782  -CVNR-------PGTFSCLCAMGFQG---PRCEGKLRPSCADSP---------------- 814

Query: 405  LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECID-VDECTSSPC-HHGD 462
                   CR+         C  +P   RC C  GYT    G C   +D C   PC  +  
Sbjct: 815  -------CRN------RATCQDSPQGPRCLCPTGYT---GGSCQTLMDLCAQKPCPRNSH 858

Query: 463  CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGG-----LCHL-GRCVNTEGSFQCVC 516
            C+    ++HC C  G+             +  +S G     LCH  G CV++  S+ C C
Sbjct: 859  CLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHC 918

Query: 517  NAGFELSPDGKNCVDHNECATSTMCVNG-VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDE 575
              GF+    G  C DH     S  C NG  C+ +   + C C PG+    G +   ++D 
Sbjct: 919  PPGFQ----GSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGY---DGQNCSKELDA 971

Query: 576  CQTPGICVNGHCTNTEGSFRCQC---LGGLAVGTDGRVCVDTHVRST----CYGAIEKGS 628
            CQ+     +G CT   G F C C     GL    D   C+D     T    C+       
Sbjct: 972  CQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFY 1031

Query: 629  CARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGI---TTDGRDINE 685
            C +  PG     + C    D     PC   P       +A   S LG       G +   
Sbjct: 1032 C-QCLPGHT--GQWCEVEID-----PCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPT 1083

Query: 686  CALDPEVCA------NGVC-ENLRGSY--RCVCNLGYEAGASGKDCTDVDE---CALNSL 733
            C+     C        G+C  + +  +  RC C  GY     G DC        C   S 
Sbjct: 1084 CSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGY----GGPDCLTPPAPKGCGPPSP 1139

Query: 734  LCDNGWCQNSPG----SYSCSCP---PGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGS 786
               NG C  + G     + CSCP   PG               C   P   G C   +G 
Sbjct: 1140 CLYNGSCSETTGLGGPGFRCSCPHSSPG-------------PRC-QKPGAKG-CEGRSGD 1184

Query: 787  YTCKC---GPGSRLDPSGTFCL----DSTKG-----TCWLKIQESRCEVNLQGASLRSEC 834
              C     GPG   D  G  C     D  KG      CWL  ++ +C          SE 
Sbjct: 1185 GACDAGCSGPGGNWD--GGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCD-----SEE 1237

Query: 835  CATLGAAWGSPCERCEIDPACARGF 859
            C   G         CE  PAC   +
Sbjct: 1238 CLFDG-------YDCETPPACTPAY 1255



 Score =  136 bits (342), Expect = 3e-31
 Identities = 172/602 (28%), Positives = 220/602 (36%), Gaps = 123/602 (20%)

Query: 50   SPGILQGPNVC-GSRFHAYC-CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGT 107
            +P + Q   +C   +  A C CP      G   C  P     C  G C Q + C C  G 
Sbjct: 630  APNLCQPKQICKDQKDKANCLCPD-----GSPGCAPPEDNCTCHHGHC-QRSSCVCDVGW 683

Query: 108  LAPSCGVSRGSGCSVSCMNGGTC----RGASCLCQKGYTGTVCGQPI--CDRG-CHNGGR 160
              P C    G   S  C +GGTC     G +C C  GYTG  C + +  C  G C NGG 
Sbjct: 684  TGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGS 743

Query: 161  C---IGPNRCACVYGFMGPQCE--RDY-RTGPCFGQ---VGPEG-----CQHQLTGLVCT 206
            C    G   C C     GPQC+   DY  + PCF     V   G     C     G  C 
Sbjct: 744  CNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCE 803

Query: 207  KAL--CCATVGRAWGLPCELCPAQPHPCRRGFIPNIHT-GACQDVDECQAVPGLCQGGSC 263
              L   CA         C+  P  P    R   P  +T G+CQ + +  A     +   C
Sbjct: 804  GKLRPSCADSPCRNRATCQDSPQGP----RCLCPTGYTGGSCQTLMDLCAQKPCPRNSHC 859

Query: 264  VNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGR 323
            +    SFHC C  G     +   C    +    + L  G     L         C + G 
Sbjct: 860  LQTGPSFHCLCLQGW----TGPLCNLPLSSCQKAALSQGIDVSSL---------CHNGGL 906

Query: 324  CWAAGPVPEL-CPPRGSNEFQ-QLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLN 381
            C  +GP     CPP     FQ  LC   +      P         G+  M  P G     
Sbjct: 907  CVDSGPSYFCHCPP----GFQGSLCQDHVNPCESRP------CQNGATCMAQPSGYLCQC 956

Query: 382  PHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLN-GRCLPTPSSYRCECNVGYT 440
              G D +                 ++ +D C+  +  C N G C P P  + C C  G+ 
Sbjct: 957  APGYDGQ---------------NCSKELDACQ--SQPCHNHGTCTPKPGGFHCACPPGFV 999

Query: 441  QDVRGECIDVDECTSSPCH---HGDCVNIPGTYHCRCYPGFQATPTRQAC-VDVDECIVS 496
              +R E  DVDEC   PCH      C ++   ++C+C PG     T Q C V++D C  S
Sbjct: 1000 -GLRCEG-DVDECLDQPCHPTGTAACHSLANAFYCQCLPGH----TGQWCEVEIDPC-HS 1052

Query: 497  GGLCHLGRCVNTEGS---FQCVCNAGFE---LSPDGKNCVDHNECATSTMCVNG------ 544
                H G C  T GS   F C C  GFE    S    +C  H+ C    +C+        
Sbjct: 1053 QPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHH-CHHGGLCLPSPKPGFP 1111

Query: 545  ---VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICV-NGHCTNTEG----SFRC 596
                CL+  G   CL  P    AP G        C  P  C+ NG C+ T G     FRC
Sbjct: 1112 PRCACLSGYGGPDCLTPP----APKG--------CGPPSPCLYNGSCSETTGLGGPGFRC 1159

Query: 597  QC 598
             C
Sbjct: 1160 SC 1161


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  304 bits (778), Expect = 9e-82
 Identities = 408/1563 (26%), Positives = 526/1563 (33%), Gaps = 355/1563 (22%)

Query: 1013 CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFE-CECFPGYESGFMLMKNCM 1070
            C  G+     E  C    EC  S  LC  G  CV  PGS + C C PG++        C 
Sbjct: 110  CCRGWMQQPDEEGCLSA-EC--SASLCFHGGRCV--PGSAQPCHCPPGFQG-----PRCQ 159

Query: 1071 -DVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQC 1129
             DVDEC      C+   C NT GSY C+C PG  L      C  I+ C+L +G C H  C
Sbjct: 160  YDVDECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQH-HC 217

Query: 1130 VNV-IGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLM 1188
            V + I   +C C  GFQ   D + CV  + C  +NG C   C    G  RC C  GY L 
Sbjct: 218  VQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLA 277

Query: 1189 PDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVD-----VDECD 1243
             DG+AC DVDEC      C  G C N  G  +C+C+ G+    D R C       V+ C+
Sbjct: 278  ADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCE 336

Query: 1244 LNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGS 1303
             N   C HG C +T    +C C  GY +      C DVD+C      C     C N PG 
Sbjct: 337  ANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDC--ADSPCCQQV-CTNNPGG 392

Query: 1304 FSCRCLPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDGFF 1359
            + C C  G+    DG  C D+DEC S    C     C N+ GS++C+C  G+    D   
Sbjct: 393  YECGCYAGYRLSADGCGCEDVDECASSRGGCEHH--CTNLAGSFQCSCEAGYRLHEDRRG 450

Query: 1360 CEDRDECAENVD--------------LCDNGQCL---NAPGGYRCECEMG---------- 1392
            C   +E   ++D              L D    L   +  G    E E+           
Sbjct: 451  CSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFV 510

Query: 1393 -FDPTEDHRACQDVDECAQGNLCAFG--SCENLPG-------------------MFRCIC 1430
              D +  H      D+C  G  C  G   C+   G                    F C C
Sbjct: 511  CLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSC 570

Query: 1431 NGGYELDR-----------GGGNCTD-------INECADPVNCIN--------GVCINTP 1464
              G   D             G NC D          C    NC N        G C+  P
Sbjct: 571  QNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDP 630

Query: 1465 GSYLCSCPQDFELNPSGVGC-VDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSL 1523
            G Y   C         G GC  + +      ++ D+ D   SCS + G    R    C L
Sbjct: 631  GLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDG--SCSCKAGFRGERCQAECEL 688

Query: 1524 GRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELP----GL------ 1573
            G         C  A T      C    G    R     +  D  QE P    G+      
Sbjct: 689  GYFGPG----CWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSC 744

Query: 1574 -CQGGDCVNTFGSFQCECPPGYHLSEHTRI----------CEDIDECSTHSGICGPGTCY 1622
             C G  C    G  QC CPPG    E              C++I     H+  C P T  
Sbjct: 745  SCGGAPCHGVTG--QCRCPPG-RTGEDCEADCPEGRWGLGCQEICPACQHAARCDPET-- 799

Query: 1623 NTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNG-------TCQNELAFNVTRKMCC 1675
                   C+C   ++    G+ C D    VC   + G       +C N+   +     C 
Sbjct: 800  -----GACLCLPGFV----GSRCQD----VCPAGWYGPSCQTRCSCANDGHCHPATGHCS 846

Query: 1676 CSYN-IGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICAN 1734
            C+    G +  R C+       PD    C   A                  G       +
Sbjct: 847  CAPGWTGFSCQRACDT--GHWGPDCSHPCNCSA------------------GHGSCDAIS 886

Query: 1735 GICINQIGSF--RCE--CPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCK 1790
            G+C+ + G    RCE  CP G         C+           CQ  A C ++ G+  C 
Sbjct: 887  GLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQ-----------CQHGAACDHVSGA--CT 933

Query: 1791 CTRGYK------LSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTL 1844
            C  G++        P G      +CR   N  +   C    GS  CLC  G +       
Sbjct: 934  CPAGWRGTFCEHACPAG--FFGLDCRSACNCTAGAACDAVNGS--CLCPAGRRGPRCAET 989

Query: 1845 CMDI---DECDRQ-PCGNG-TCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTT-LVGQVC 1898
            C        C +   C NG +C  + G   C C PG++      C+    C   L G  C
Sbjct: 990  CPAHTYGHNCSQACACFNGASCDPVHG--QCHCAPGWM---GPSCL--QACPAGLYGDNC 1042

Query: 1899 RFGHCLNTAG-----SFHCLCQDGFELTADGKNCV--DTNECLSLAGTCL-PGTCQNLEG 1950
            R        G     S HC C +G+   A  K C+  D       +G CL  G C    G
Sbjct: 1043 RHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTG 1102

Query: 1951 SFRCICPPGFQVQSDHCIDI-------DECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLS 2003
              RC+CP G+    D C          + C++  +      C +  G+  C CPPGF   
Sbjct: 1103 --RCLCPAGW--TGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGA--CRCPPGF--- 1153

Query: 2004 DNGHRCFDTRQSFCFTRFEAGKCSVP---KAFNTTKTRCCCSKRPGEGWGDPCELCPQEG 2060
              G  C        F    A  C  P    A +     C C+     G+  P        
Sbjct: 1154 -TGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCA----AGYHGP-------- 1200

Query: 2061 SAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPF-GYSLDF 2119
              + Q+ CP G    PG          C +  G    G C    G+ RC   F G   + 
Sbjct: 1201 --SCQQRCPPGRYG-PG----------CEQLCGCLNGGSCDAATGACRCPTGFLGTDCNL 1247

Query: 2120 T------GINCVDTDECSVGHPCG--QGTCTNVIGGFECACADGFEPGLM-MTCEDIDEC 2170
            T      G NC     C  G  C    GTC    G     C  G       + CE    C
Sbjct: 1248 TCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSC 1307

Query: 2171 SLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA-RGMECKNLI 2229
                L     CH + GS  C+C  G+T R     C      A    +C       C+   
Sbjct: 1308 RNGGL-----CHASNGS--CSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPAT 1360

Query: 2230 GTFAC-----------VCPPGMRPLPGSGEGCTDDNEC-HAQPDLCVNGRCVNTAGSFRC 2277
            GT  C            CPPG       G GC     C H  P   ++GRC+  AG    
Sbjct: 1361 GTCRCGPGFYGQACEHPCPPGFH-----GAGCQGLCWCQHGAPCDPISGRCLCPAGFHGH 1415

Query: 2278 DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCE 2337
             C+ G +P      CH                              C C GG    P   
Sbjct: 1416 FCERGCEPGSFGEGCHQ----------------------------RCDCDGGAPCDPVTG 1447

Query: 2338 LCPLPGTSAYRKLCPHG-SGYTA-----EGRDVDECRMLAHLCAHGECINSLGSFRCHCQ 2391
            LC          LCP G SG T       G+    C +        +C    G  +CHC 
Sbjct: 1448 LC----------LCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSG--QCHCV 1495

Query: 2392 AGY 2394
             GY
Sbjct: 1496 DGY 1498



 Score =  296 bits (757), Expect = 3e-79
 Identities = 410/1596 (25%), Positives = 551/1596 (34%), Gaps = 336/1596 (21%)

Query: 830  LRSECCATLGAAWGSPCERCEIDPA-CARGFARMTGVTCD-DVNECESFPGVCPNGRCVN 887
            L +EC A+L    G  C      P  C  GF    G  C  DV+EC +  G C + RCVN
Sbjct: 124  LSAECSASL-CFHGGRCVPGSAQPCHCPPGFQ---GPRCQYDVDECRTHNGGCQH-RCVN 178

Query: 888  TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVW 947
            T GS+ CEC  G  L    R C+ +           + C +   G        C    + 
Sbjct: 179  TPGSYLCECKPGFRLHTDSRTCLAI-----------NSCALGNGGCQHH----CVQLTIT 223

Query: 948  GVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVG 1007
               C+  P  +  E    C R    A+R+                  G C H  C+   G
Sbjct: 224  RHRCQCRPGFQLQEDGRHCVRRSPCANRN------------------GSCMH-RCQVVRG 264

Query: 1008 SFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYE---SGFM 1064
               C C  G+ L A  + C D+DEC      C  G C+NT GSF+C C  GYE    G  
Sbjct: 265  LARCECHVGYQLAADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQ 323

Query: 1065 LMKNCMD-VDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL 1123
              +  M+ V+ C  +   C  G C++T     C CP G+EL      C D+D+C+  D  
Sbjct: 324  CYRIEMEIVNSCEANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA--DSP 380

Query: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQ 1183
            C    C N  G ++C C+AG++ + D  GC D++EC    GGC+ HC N  GS++CSC  
Sbjct: 381  CCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEA 440

Query: 1184 GYSLMPDGRACADVDECEENPRVCDQGHCTNM-PGGHRCLCYDGF-MATPDMRTCVDVDE 1241
            GY L  D R C+ ++E    P V   G    + P  H  +  D       D     D +E
Sbjct: 441  GYRLHEDRRGCSPLEE----PMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEE 496

Query: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301
             +L     L         SF   C L              D+C  GG       +CL   
Sbjct: 497  AELRGEHTLTEKFVCLDDSFGHDCSL------------TCDDCRNGG-------TCL--L 535

Query: 1302 GSFSCRCLPGWVGDGFECHD------LDECVSQEHRCSPRGDCLNVPGSYRCT------- 1348
            G   C C  GW   G  C++        +  S    C   G C +V G+ RC        
Sbjct: 536  GLDGCDCPEGWT--GLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTN 593

Query: 1349 ----CRQGFAGDGFFCEDRDECAENVDLCDN--GQCLNAPGGYRCECEMGFDPTEDHRAC 1402
                C +G+ G    C  +  CA N   C    G CL  PG Y   C +   P      C
Sbjct: 594  CEDGCPKGYYGK--HCRKKCNCA-NRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGC 650

Query: 1403 QDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCIN 1462
             +  +C Q +     SC+   G   C C  G+  +R    C               +   
Sbjct: 651  SEECQCVQPHT---QSCDKRDG--SCSCKAGFRGERCQAECE--------------LGYF 691

Query: 1463 TPGSY-LCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASC-- 1519
             PG +  C+C       P GV C D+ +G C  +    G  G  C  E  VG    +C  
Sbjct: 692  GPGCWQACTC-------PVGVAC-DSVSGECG-KRCPAGFQGEDCGQECPVGTFGVNCSS 742

Query: 1520 CCSLGRAWGNPCE------LCPMANTTE-YRTLCPGGE-GFQPNRITVILEDIDECQELP 1571
             CS G   G PC        CP   T E     CP G  G     I    +    C    
Sbjct: 743  SCSCG---GAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPET 799

Query: 1572 GLCQGGDCVNTFGSFQCE--CPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYT 1629
            G C    C+  F   +C+  CP G++             C T       G C+   G+ +
Sbjct: 800  GACL---CLPGFVGSRCQDVCPAGWY----------GPSCQTRCSCANDGHCHPATGHCS 846

Query: 1630 CVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMC-----CCSYNIGQAW 1684
            C           G      +++    H+   C +    +     C      C    G   
Sbjct: 847  CA---------PGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVG 897

Query: 1685 NRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSF 1744
             R  + CP           G+  PG                 E    C +G   + + S 
Sbjct: 898  PRCEQQCPQ----------GHFGPGC----------------EQRCQCQHGAACDHV-SG 930

Query: 1745 RCECPAGFNYNSILLACEDVD---ECGSRESPCQQNADCINIPGSYRC-------KC--- 1791
             C CPAG+       AC       +C S    C   A C  + GS  C       +C   
Sbjct: 931  ACTCPAGWRGTFCEHACPAGFFGLDCRS-ACNCTAGAACDAVNGSCLCPAGRRGPRCAET 989

Query: 1792 ----TRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEG----SYMCLCHRGFQASADQT 1843
                T G+  S   AC     C  +     HG C    G    S +  C  G      + 
Sbjct: 990  CPAHTYGHNCSQACACFNGASCDPV-----HGQCHCAPGWMGPSCLQACPAGLYGDNCRH 1044

Query: 1844 LCMDIDECDRQPCGN-GTCKNIIGSYNCLCFPGFV-VTHNGDCVDFDECTTLVGQVCRF- 1900
             C+         C N GTC  + G  +C C  G+  +    +C+  D     V   CR  
Sbjct: 1045 SCL---------CQNGGTCDPVSG--HCACPEGWAGLACEKECLPRD-----VRAGCRHS 1088

Query: 1901 GHCLN----TAGSFHCLCQDGFELTADGKNCVD--TNECLSLAGTCLPG-TCQNLEGSFR 1953
            G CLN       +  CLC  G+        C+     E  +   +C PG  C ++ G+  
Sbjct: 1089 GGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGA-- 1146

Query: 1954 CICPPGFQVQ-----------SDHCIDIDECSEEPNLC--LFGTCTNSPG----SFQCLC 1996
            C CPPGF               + C  + +C  E   C    GTC+ + G    S Q  C
Sbjct: 1147 CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRC 1206

Query: 1997 PPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRP---------GE 2047
            PPG         C       C      G C  P  F  T     C +           G 
Sbjct: 1207 PPGRYGPGCEQLCGCLNGGSCDA--ATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGC 1264

Query: 2048 GWGDPCELCPQEGSAAFQELCPFGHGAV---PGPDDSREDVNECAENPGVCTNGVCVNTD 2104
            G G  C+  P  G+     LCP G   V    G   +R  V  C         G+C  ++
Sbjct: 1265 GQGAACD--PVTGTC----LCPPGRAGVRCERGCPQNRFGVG-CEHTCSCRNGGLCHASN 1317

Query: 2105 GSFRCECPFGYSLDFTGINCVD---TDECSVGHPC-GQGTCTNVIGGFECACADGFEPGL 2160
            GS  C C  G++     + C        C +   C    TC    G   C C  GF    
Sbjct: 1318 GS--CSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATG--TCRCGPGF---Y 1370

Query: 2161 MMTCEDIDECSLNPLLCAFRCHNTEG------SYLCTCPAGYTLREDGAMCRDVDECADG 2214
               CE       +   C   C    G      S  C CPAG+     G  C    E    
Sbjct: 1371 GQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGF----HGHFCERGCEPGSF 1426

Query: 2215 QQDCHAR-----GMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCV 2269
             + CH R     G  C  + G   C+CPPG      SG  C  D         C  G+  
Sbjct: 1427 GEGCHQRCDCDGGAPCDPVTG--LCLCPPGR-----SGATCNLD---------CRRGQ-F 1469

Query: 2270 NTAGSFRCDCDEGFQPSPTLTECH--DIRQGPCFAE 2303
              + +  CDC  G    P   +CH  D   GP   E
Sbjct: 1470 GPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCRE 1505



 Score =  279 bits (713), Expect = 3e-74
 Identities = 416/1598 (26%), Positives = 545/1598 (34%), Gaps = 359/1598 (22%)

Query: 1257 TKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFS-CRCLPGWVGD 1315
            T+   V  C  G+M +    GC      E     C     C  +PGS   C C PG+ G 
Sbjct: 102  TEARTVLRCCRGWMQQPDEEGCLSA---ECSASLCFHGGRC--VPGSAQPCHCPPGFQGP 156

Query: 1316 GFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDGFFCEDRDECAENVDLC 1373
              + +D+DEC +    C  R  C+N PGSY C C+ GF    D   C   + CA     C
Sbjct: 157  RCQ-YDVDECRTHNGGCQHR--CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGC 213

Query: 1374 DNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGG 1433
             +         +RC+C  GF   ED R C     CA  N      C+ + G+ RC C+ G
Sbjct: 214  QHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVG 273

Query: 1434 YELDRGGGNCTDINECADPV-NCINGVCINTPGSYLCSCPQDFELNPSGVGC--VDTRAG 1490
            Y+L   G  C D++ECA  +  C +G C+NT GS+ C C   +EL   G  C  ++    
Sbjct: 274  YQLAADGKACEDVDECAAGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIV 332

Query: 1491 NCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGE 1550
            N             SC A  G         CS G +  +   LC           CP G 
Sbjct: 333  N-------------SCEANNG--------GCSHGCSHTSAGPLC----------TCPRGY 361

Query: 1551 GFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECS 1610
                ++ T I  D+D+C + P  C    C N  G ++C C  GY LS     CED+DEC+
Sbjct: 362  ELDTDQRTCI--DVDDCADSP--CCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECA 417

Query: 1611 THSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNC-------MDMRKSVCFRH---YNGT 1660
            +  G C    C N  G++ C C A Y        C       +D+   + F     +   
Sbjct: 418  SSRGGC-EHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAV 476

Query: 1661 CQNEL--------------------AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQ 1700
             Q+EL                       +T K  C   + G   +  C+ C         
Sbjct: 477  LQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNG-GTCLL 535

Query: 1701 ILCGNQAPGFLTDIHTGKPLDIDECGE---IPAICAN-GICINQIGSFRCECPAGFNYNS 1756
             L G   P   T +   +    D  G+       C N G C +  G+  C CP G +  +
Sbjct: 536  GLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGA--CRCPPGVSGTN 593

Query: 1757 ILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVC 1816
                CED    G     C++  +C N     R +C R Y                     
Sbjct: 594  ----CEDGCPKGYYGKHCRKKCNCAN-----RGRCHRLY--------------------- 623

Query: 1817 SHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGF 1876
              G C+   G Y   CH      A    C   +EC        +C    GS  C C  GF
Sbjct: 624  --GACLCDPGLYGRFCHLTCPPWAFGPGCS--EECQCVQPHTQSCDKRDGS--CSCKAGF 677

Query: 1877 VVTH-NGDCV-------DFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV 1928
                   +C         +  CT  VG  C      + +G     C  GF+    G+ C 
Sbjct: 678  RGERCQAECELGYFGPGCWQACTCPVGVACD-----SVSGECGKRCPAGFQGEDCGQECP 732

Query: 1929 DTNECLSLAGTCLPG--TCQNLEGSFRCICPPGFQVQSDHCIDIDE------CSEEPNLC 1980
                 ++ + +C  G   C  + G  +C CPPG +   D   D  E      C E    C
Sbjct: 733  VGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPG-RTGEDCEADCPEGRWGLGCQEICPAC 789

Query: 1981 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC 2040
                  + P +  CLC PGFV    G RC    Q  C   +    C         +TRC 
Sbjct: 790  QHAARCD-PETGACLCLPGFV----GSRC----QDVCPAGWYGPSC---------QTRCS 831

Query: 2041 CSK----RPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVC- 2095
            C+      P  G    C   P     + Q  C  GH    GPD S      C+   G C 
Sbjct: 832  CANDGHCHPATG---HCSCAPGWTGFSCQRACDTGHW---GPDCSHP--CNCSAGHGSCD 883

Query: 2096 -TNGVCVNTDGSF--RCE--CPFGYSLDFTGINCVDTDECSVGHPCG--QGTCTNVIG-- 2146
              +G+C+   G    RCE  CP G+     G  C    +C  G  C    G CT   G  
Sbjct: 884  AISGLCLCEAGYVGPRCEQQCPQGH----FGPGCEQRCQCQHGAACDHVSGACTCPAGWR 939

Query: 2147 GFEC--ACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAM 2204
            G  C  AC  GF     + C     C+         C    GS  C CPAG      G  
Sbjct: 940  GTFCEHACPAGF---FGLDCRSACNCT-----AGAACDAVNGS--CLCPAG----RRGPR 985

Query: 2205 CRDVDECADGQQDCHA-----RGMECKNLIGTFACVCPPG-MRP--LPGSGEGCTDDNEC 2256
            C +         +C        G  C  + G   C C PG M P  L     G   DN  
Sbjct: 986  CAETCPAHTYGHNCSQACACFNGASCDPVHG--QCHCAPGWMGPSCLQACPAGLYGDNCR 1043

Query: 2257 HAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTEC--HDIRQGPCFAEVLQTMCR---- 2310
            H+   LC NG   +   S  C C EG+       EC   D+R G          CR    
Sbjct: 1044 HS--CLCQNGGTCDPV-SGHCACPEGWAGLACEKECLPRDVRAG----------CRHSGG 1090

Query: 2311 SLSSSSEAVTRAECCCGGG-----------RGW-----GPRCELCPLPGTSAYR--KLCP 2352
             L+          C C  G           RGW       RC  CP PG + +     C 
Sbjct: 1091 CLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCS-CP-PGAACHHVTGACR 1148

Query: 2353 HGSGYTAEGRDV--------DECRMLAHLCAHG-ECINSLGSFRCHCQAGYTPDATATTC 2403
               G+T  G +         ++C  +         C  + G+  C C AGY       +C
Sbjct: 1149 CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGT--CSCAAGY----HGPSC 1202

Query: 2404 LDMDECSQVPKPCTFLCKNTKG------SFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC 2457
                   +    C  LC    G      +  C CP G+L  +   TC           NC
Sbjct: 1203 QQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQ----GRFGPNC 1258

Query: 2458 QFLCVNTVGAF------TCRCPPGFT-----------------QHHQACFDNDECSAQPG 2494
              +C    GA       TC CPPG                   +H  +C +   C A  G
Sbjct: 1259 THVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNG 1318

Query: 2495 PC--------------------GAHGH----CHNT----PGSFRCECHQGFTLVSSGHGC 2526
             C                    GA  H    CHN     P +  C C  GF   +  H C
Sbjct: 1319 SCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPC 1378

Query: 2527 EDVNE---CDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDEN---ECALSPPTCG 2580
                    C G   CQHG        RC CP GF  H     C   +    C       G
Sbjct: 1379 PPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDG 1438

Query: 2581 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQG 2639
             A C    G   C+CP G       G    +D   G+ GP C+  C +  GG  C     
Sbjct: 1439 GAPCDPVTG--LCLCPPG-----RSGATCNLDCRRGQFGPSCTLHC-DCGGGADCDPV-- 1488

Query: 2640 YFRAGQGHCVSGLGFSP-----GPQDTPDKEELLSSEA 2672
               +GQ HCV G    P     GP   P+   L    A
Sbjct: 1489 ---SGQCHCVDGY-MGPTCREGGPLRLPENPSLAQGSA 1522



 Score =  278 bits (712), Expect = 4e-74
 Identities = 431/1651 (26%), Positives = 558/1651 (33%), Gaps = 382/1651 (23%)

Query: 473  RCYPGFQATPTRQACVDVDECIVSGGLC-HLGRCVNTEGSFQ-CVCNAGFELSPDGKNC- 529
            RC  G+   P  + C+   EC  S  LC H GRCV   GS Q C C  GF+    G  C 
Sbjct: 109  RCCRGWMQQPDEEGCLSA-EC--SASLCFHGGRCV--PGSAQPCHCPPGFQ----GPRCQ 159

Query: 530  VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTN 589
             D +EC T        C+N  GS+ C CKPGF L      C+ I+ C         HC  
Sbjct: 160  YDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQ 219

Query: 590  -TEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPD 648
             T    RCQC  G  +  DGR CV    RS C  A   GSC                   
Sbjct: 220  LTITRHRCQCRPGFQLQEDGRHCVR---RSPC--ANRNGSCMHR---------------- 258

Query: 649  HGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSY 705
                  CQ+       E    C  G  +  DG+   D++ECA     CA+G C N +GS+
Sbjct: 259  ------CQVVRGLARCE----CHVGYQLAADGKACEDVDECAAGLAQCAHG-CLNTQGSF 307

Query: 706  RCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYS----CSCPPGFHFWQDT 761
            +CVC+ GYE GA G+ C  ++   +NS   +NG C +     S    C+CP G+    D 
Sbjct: 308  KCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQ 367

Query: 762  EICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRC 821
              C DVD+C  SPC   VC N  G Y C C  G RL   G  C D               
Sbjct: 368  RTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVD------------- 414

Query: 822  EVNLQGASLRSEC---CATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNE-CESFP 877
                + AS R  C   C  L  ++   CE         RG        C  + E      
Sbjct: 415  ----ECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRG--------CSPLEEPMVDLD 462

Query: 878  GVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMD 937
            G  P  R +      + E P+    D  G               DE+E    L G++ + 
Sbjct: 463  GELPFVRPLPHIAVLQDELPQLFQDDDVGA--------------DEEE--AELRGEHTLT 506

Query: 938  VCCCSIGAVWGVECE-ACPDPESLEFASL------CPRG-LGFASRDFLSGRPFYKDVNE 989
                 +   +G +C   C D  +     L      CP G  G    +      F K+   
Sbjct: 507  EKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKN--- 563

Query: 990  CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTD---IDECRISPDLCGQGTCVN 1046
            C         GTC +  G+  C C  G +    E  C        CR   +   +G C  
Sbjct: 564  CSFSCSCQNGGTCDSVTGA--CRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHR 621

Query: 1047 TPGSFECECFPGYESGFMLM--------KNCMDVDECARDPLLCRGGTCTNTDGSYKCQC 1098
              G+  C C PG    F  +          C +  +C +        +C   DGS  C C
Sbjct: 622  LYGA--CLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQP----HTQSCDKRDGS--CSC 673

Query: 1099 PPGHELTAKGTACEDIDECSL--------SDGLCPHG-QCVNVIGAFQCSCHAGFQSTPD 1149
              G     +G  C+   EC L            CP G  C +V G     C AGFQ    
Sbjct: 674  KAGF----RGERCQ--AECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDC 727

Query: 1150 RQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQ 1209
             Q      EC V  G   V+C     S  CSCG        G  C  V            
Sbjct: 728  GQ------ECPV--GTFGVNC-----SSSCSCG--------GAPCHGV-----------T 755

Query: 1210 GHCTNMPG--GHRCL--CYDGFMATPDMRTCVDVDECDLNPHICLH-GDCENTKGSFVCH 1264
            G C   PG  G  C   C +G         C            C H   C+   G+  C 
Sbjct: 756  GQCRCPPGRTGEDCEADCPEGRWGLGCQEIC----------PACQHAARCDPETGA--CL 803

Query: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLN----IPGSFSCRCLPGWVGDGFEC- 1319
            C  G++     + C DV      G +C +  SC N     P +  C C PGW   GF C 
Sbjct: 804  CLPGFV----GSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWT--GFSCQ 857

Query: 1320 ------HDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAG--------DGFF---CED 1362
                  H   +C    +  +  G C  + G   C C  G+ G         G F   CE 
Sbjct: 858  RACDTGHWGPDCSHPCNCSAGHGSCDAISG--LCLCEAGYVGPRCEQQCPQGHFGPGCEQ 915

Query: 1363 RDECAENVDLCD--NGQCLNAPGGYR---CE--CEMGFDPTEDHRACQDVDECAQGNLC- 1414
            R +C      CD  +G C   P G+R   CE  C  GF   +   AC     C  G  C 
Sbjct: 916  RCQCQHGA-ACDHVSGAC-TCPAGWRGTFCEHACPAGFFGLDCRSAC----NCTAGAACD 969

Query: 1415 -AFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNC--INGVCINTPG----SY 1467
               GSC    G     C         G NC+    C +  +C  ++G C   PG    S 
Sbjct: 970  AVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSC 1029

Query: 1468 LCSCPQDFELNPSGVGCVDTRAGNCF-LETH---DRGDSGISCSAEIGVGVTRASCCCSL 1523
            L +CP     +     C+    G C  +  H     G +G++C  E      RA C  S 
Sbjct: 1030 LQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSG 1089

Query: 1524 GRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDE-CQELPGLCQGGDCVNT 1582
            G   G  C+  P       R LCP G      +   +     E C +      G  C + 
Sbjct: 1090 GCLNGGLCD--PHTG----RCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHV 1143

Query: 1583 FGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGG 1642
             G+  C CPPG+  S     CE           C PG+         C CP E       
Sbjct: 1144 TGA--CRCPPGFTGSG----CEQ---------ACPPGSFGEDCAQ-MCQCPGE------- 1180

Query: 1643 NNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQIL 1702
                    +       GTC            C   Y+ G +  + C   P    P  + L
Sbjct: 1181 --------NPACHPATGTCS-----------CAAGYH-GPSCQQRCP--PGRYGPGCEQL 1218

Query: 1703 CGNQAPGFLTDIHTGKPLDIDECGEIPAICAN-GICINQIGSFRCECPAGFNYNSILLAC 1761
            CG                           C N G C    G+  C CP GF      L C
Sbjct: 1219 CG---------------------------CLNGGSCDAATGA--CRCPTGFLGTDCNLTC 1249

Query: 1762 ED---------VDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSP-GGACVGRNECRE 1811
                       V  CG   +       C+  PG    +C RG   +  G  C     CR 
Sbjct: 1250 PQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCR- 1308

Query: 1812 IPNVCSHGDCMDTEGSYMC-----------LCHRGFQASADQTLCMDIDECDRQPCGNGT 1860
                 + G C  + GS  C            C  G   +A    C   +    +P   GT
Sbjct: 1309 -----NGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEP-ATGT 1362

Query: 1861 CKNIIGSYNCLCF----PGFVVTHNGDCVDFDECTTLVGQVCR--FGHCLNTAGSFHCLC 1914
            C+   G Y   C     PGF   H   C     C    G  C    G CL  AG     C
Sbjct: 1363 CRCGPGFYGQACEHPCPPGF---HGAGCQGL--CWCQHGAPCDPISGRCLCPAGFHGHFC 1417

Query: 1915 QDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECS 1974
            + G E  + G+ C    +C   A       C  + G   C+CPPG    + + +D     
Sbjct: 1418 ERGCEPGSFGEGCHQRCDCDGGA------PCDPVTG--LCLCPPGRSGATCN-LDCRRGQ 1468

Query: 1975 EEPNLCLFGTCTN----SPGSFQCLCPPGFV 2001
              P+  L   C       P S QC C  G++
Sbjct: 1469 FGPSCTLHCDCGGGADCDPVSGQCHCVDGYM 1499



 Score =  262 bits (670), Expect = 3e-69
 Identities = 416/1622 (25%), Positives = 523/1622 (32%), Gaps = 393/1622 (24%)

Query: 137  CQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRT--GPCFG---QV 191
            C +  + TV   P+   GC     C+G  R    Y         + RT    C G   Q 
Sbjct: 62   CVQALSHTV---PVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQP 118

Query: 192  GPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQ-DVDE 250
              EGC        C+ +LC        G  C    AQP  C  GF        CQ DVDE
Sbjct: 119  DEEGC----LSAECSASLCFH------GGRCVPGSAQPCHCPPGF----QGPRCQYDVDE 164

Query: 251  CQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAG 310
            C+   G CQ   CVN  GS+ C C  G RL   S  C      +C   L  G C      
Sbjct: 165  CRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRTC--LAINSC--ALGNGGCQHHCVQ 219

Query: 311  -HYTRRQCCC--------DRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPG------ 355
               TR +C C        D   C    P    C  R  +     C  R  ++ G      
Sbjct: 220  LTITRHRCQCRPGFQLQEDGRHCVRRSP----CANRNGS-----CMHRCQVVRGLARCEC 270

Query: 356  HPGLFPGLLGFGSNGMGP-PLGPAR-----LNPHGS---DARGIPSLGPGNSNIGTATLN 406
            H G      G     +     G A+     LN  GS          LG          + 
Sbjct: 271  HVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEM- 329

Query: 407  QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDV-RGECIDVDECTSSPCHHGDCVN 465
            + ++ C      C +G C  T +   C C  GY  D  +  CIDVD+C  SPC    C N
Sbjct: 330  EIVNSCEANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTN 388

Query: 466  IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPD 525
             PG Y C CY G++ +     C DVDEC  S G C    C N  GSFQC C AG+ L  D
Sbjct: 389  NPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCE-HHCTNLAGSFQCSCEAGYRLHED 447

Query: 526  GKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDE---------- 575
             + C    E            ++ DG           + P  H  +  DE          
Sbjct: 448  RRGCSPLEE----------PMVDLDGELP-------FVRPLPHIAVLQDELPQLFQDDDV 490

Query: 576  -CQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFP 634
                    + G  T TE   +  CL           C D     TC   ++   C   + 
Sbjct: 491  GADEEEAELRGEHTLTE---KFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWT 547

Query: 635  GTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCA 694
            G +    C    P   FG+ C          F   C +G                     
Sbjct: 548  GLICNETC----PPDTFGKNC---------SFSCSCQNG--------------------- 573

Query: 695  NGVCENLRGSYRCV-------CNLGYEAGASGKDCTDVDECALNSLLCDN--GWCQNSPG 745
             G C+++ G+ RC        C  G   G  GK C     CA N   C    G C   PG
Sbjct: 574  -GTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCA-NRGRCHRLYGACLCDPG 631

Query: 746  SYS----CSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCG-PGSRLD-- 798
             Y      +CPP    W     C +  +C+     S  C    GS +CK G  G R    
Sbjct: 632  LYGRFCHLTCPP----WAFGPGCSEECQCVQPHTQS--CDKRDGSCSCKAGFRGERCQAE 685

Query: 799  ----------------PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAW 842
                            P G  C DS  G C       RC    QG     EC       +
Sbjct: 686  CELGYFGPGCWQACTCPVGVAC-DSVSGEC-----GKRCPAGFQGEDCGQECPV---GTF 736

Query: 843  GSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLML 902
            G  C       +C+ G A   GVT     +C      CP GR   T      +CPEG   
Sbjct: 737  GVNC-----SSSCSCGGAPCHGVT----GQCR-----CPPGR---TGEDCEADCPEG--- 776

Query: 903  DASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEF 962
                             RW    C    P       C    GA     C   P       
Sbjct: 777  -----------------RWGLG-CQEICPACQHAARCDPETGA-----CLCLPGFVGSRC 813

Query: 963  ASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQ 1022
              +CP G    S               C+        G C    G  HC+CA G+   + 
Sbjct: 814  QDVCPAGWYGPS---------------CQTRCSCANDGHCHPATG--HCSCAPGWTGFSC 856

Query: 1023 ERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLC 1082
            +R C   D     PD            S  C C  G+ S   +   C           LC
Sbjct: 857  QRAC---DTGHWGPDC-----------SHPCNCSAGHGSCDAISGLC-----------LC 891

Query: 1083 RGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHG-QCVNVIGAFQCSCH 1141
              G         + QCP GH     G  CE    C      C HG  C +V GA  C+C 
Sbjct: 892  EAG---YVGPRCEQQCPQGH----FGPGCE--QRCQ-----CQHGAACDHVSGA--CTCP 935

Query: 1142 AGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGR---ACADVD 1198
            AG++ T     C            C   C  T G+  C    G  L P GR    CA+  
Sbjct: 936  AGWRGTFCEHAC----PAGFFGLDCRSACNCTAGA-ACDAVNGSCLCPAGRRGPRCAETC 990

Query: 1199 ECEENPRVCDQG-HCTN----MPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICL--- 1250
                    C Q   C N     P   +C C  G+M    ++ C      D   H CL   
Sbjct: 991  PAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQN 1050

Query: 1251 HGDCENTKGSFVC-------HCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGS 1303
             G C+   G   C        C+   + R    GC     C  GG  CD H         
Sbjct: 1051 GGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGG-LCDPHTG------- 1102

Query: 1304 FSCRCLPGWVGDGFECHDL----DECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFF 1359
              C C  GW GD  +   L     E  +Q   C P   C +V G+  C C  GF G G  
Sbjct: 1103 -RCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGA--CRCPPGFTGSG-- 1157

Query: 1360 CEDR-------DECAENVDLCD-----------NGQCLNAPGGYRCECEMGFDPTEDHRA 1401
            CE         ++CA+   +C             G C  A G +   C+    P      
Sbjct: 1158 CEQACPPGSFGEDCAQ---MCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPG 1214

Query: 1402 CQDVDECAQGNLC--AFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNC--IN 1457
            C+ +  C  G  C  A G+C    G     CN      R G NCT +  C     C  + 
Sbjct: 1215 CEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVT 1274

Query: 1458 GVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRA 1517
            G C+  PG     C +    N  GVGC  T +            +G  C A  G      
Sbjct: 1275 GTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCR----------NGGLCHASNG------ 1318

Query: 1518 SCCCSLGRAW-GNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQG 1576
            SC C LG  W G  CEL            CP G       +     +   C+   G C+ 
Sbjct: 1319 SCSCGLG--WTGRHCELA-----------CPPGRYGAACHLECSCHNNSTCEPATGTCR- 1364

Query: 1577 GDCVNTFGSFQCE--CPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPA 1634
              C   F    CE  CPPG+H +     C+ +  C  H   C P        +  C+CPA
Sbjct: 1365 --CGPGFYGQACEHPCPPGFHGAG----CQGLCWCQ-HGAPCDP-------ISGRCLCPA 1410

Query: 1635 EY 1636
             +
Sbjct: 1411 GF 1412



 Score =  224 bits (570), Expect = 1e-57
 Identities = 259/926 (27%), Positives = 330/926 (35%), Gaps = 180/926 (19%)

Query: 1803 CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCK 1862
            CVG    R       +     TE   +  C RG+    D+  C+   EC    C +G  +
Sbjct: 83   CVGHE--RRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSA-ECSASLCFHGG-R 138

Query: 1863 NIIGSYN-CLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
             + GS   C C PGF       C  D DEC T  G  C+   C+NT GS+ C C+ GF L
Sbjct: 139  CVPGSAQPCHCPPGF---QGPRCQYDVDECRTHNGG-CQH-RCVNTPGSYLCECKPGFRL 193

Query: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPN 1978
              D + C+  N C    G C     Q      RC C PGFQ+Q D  HC+    C+    
Sbjct: 194  HTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNG 253

Query: 1979 LCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTR 2038
             C+   C    G  +C C  G+ L+ +G  C D  +        AG          T+  
Sbjct: 254  SCMH-RCQVVRGLARCECHVGYQLAADGKACEDVDEC------AAGLAQCAHGCLNTQGS 306

Query: 2039 CCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNG 2098
              C    G   G     C +                        E VN C  N G C++G
Sbjct: 307  FKCVCHAGYELGADGRQCYR---------------------IEMEIVNSCEANNGGCSHG 345

Query: 2099 VCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEP 2158
             C +T     C CP GY LD     C+D D+C+   PC Q  CTN  GG+EC C  G+  
Sbjct: 346  -CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA-DSPCCQQVCTNNPGGYECGCYAGYRL 403

Query: 2159 GL-MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
                  CED+DEC+ +   C   C N  GS+ C+C AGY L ED   C  ++E       
Sbjct: 404  SADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE------- 456

Query: 2218 CHARGMECKNLIGTFACVCPPGMRPLP------------------GSGEG---------- 2249
                     +L G       P +RPLP                  G+ E           
Sbjct: 457  ------PMVDLDGEL-----PFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTL 505

Query: 2250 -----CTDD---NECHAQPDLCVN-GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPC 2300
                 C DD   ++C    D C N G C+   G   CDC EG+    T   C++      
Sbjct: 506  TEKFVCLDDSFGHDCSLTCDDCRNGGTCL--LGLDGCDCPEGW----TGLICNETCPPDT 559

Query: 2301 FAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCE-LCPLPGTSAYRKLCPHGSGYTA 2359
            F +     C   +  +       C C  G   G  CE  CP      Y K C        
Sbjct: 560  FGKNCSFSCSCQNGGTCDSVTGACRCPPGVS-GTNCEDGCP---KGYYGKHCRKKCNCAN 615

Query: 2360 EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFL 2419
             GR    C  L     +G C+   G +   C     P A    C +  +C Q   P T  
Sbjct: 616  RGR----CHRL-----YGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQ---PHTQS 663

Query: 2420 CKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTC--------- 2470
            C    GS  CSC  G+     G  C+   E       C   C   VG   C         
Sbjct: 664  CDKRDGS--CSCKAGF----RGERCQAECELGYFGPGCWQACTCPVGV-ACDSVSGECGK 716

Query: 2471 RCPPGFTQHH--QAC-------FDNDECSAQPGPC-GAHGHCHNTPGSFRCECHQGFTLV 2520
            RCP GF      Q C         +  CS    PC G  G C   PG    +C       
Sbjct: 717  RCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEG 776

Query: 2521 SSGHGCEDVNECDGPHRCQHG--CQNQLG---------GYRCS--CPQGFTQHSQWAQCV 2567
              G GC+++  C     CQH   C  + G         G RC   CP G+   S   +C 
Sbjct: 777  RWGLGCQEI--CPA---CQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS 831

Query: 2568 DENECALSPPTCGSASCRNTLGGFRC--VCPSGFDFDQALGGCQEVDECAGRRGPC---S 2622
              N+    P T G  SC     GF C   C +G         C     C+   G C   S
Sbjct: 832  CANDGHCHPAT-GHCSCAPGWTGFSCQRACDTGHWGPD----CSHPCNCSAGHGSCDAIS 886

Query: 2623 YSCANTPG--GFLC--GCPQGYFRAG 2644
              C    G  G  C   CPQG+F  G
Sbjct: 887  GLCLCEAGYVGPRCEQQCPQGHFGPG 912



 Score =  215 bits (547), Expect = 6e-55
 Identities = 383/1526 (25%), Positives = 511/1526 (33%), Gaps = 298/1526 (19%)

Query: 90   CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGAS---CLCQKGYTGTVC 146
            C  G+  QP+     +G L+  C  S        C +GG C   S   C C  G+ G  C
Sbjct: 110  CCRGWMQQPD----EEGCLSAECSASL-------CFHGGRCVPGSAQPCHCPPGFQGPRC 158

Query: 147  GQPICDRGCHNGG---RCI---GPNRCACVYGFMGPQCERDYRTGPCFGQ--VGPEGCQH 198
               + +   HNGG   RC+   G   C C  GF   +   D RT        +G  GCQH
Sbjct: 159  QYDVDECRTHNGGCQHRCVNTPGSYLCECKPGF---RLHTDSRTCLAINSCALGNGGCQH 215

Query: 199  QLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLC 258
                L  T+  C    G       +L     H  RR    N   G+C  +  CQ V GL 
Sbjct: 216  HCVQLTITRHRCQCRPG------FQLQEDGRHCVRRSPCAN-RNGSC--MHRCQVVRGLA 266

Query: 259  QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCC 318
            +            C C VG++L+    ACED     C + L   +CA          +C 
Sbjct: 267  R------------CECHVGYQLAADGKACED--VDECAAGL--AQCAHGCLNTQGSFKCV 310

Query: 319  CDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG-PPLGP 377
            C  G  +  G     C  R   E    C                  G  S+G      GP
Sbjct: 311  CHAG--YELGADGRQCY-RIEMEIVNSCEANN--------------GGCSHGCSHTSAGP 353

Query: 378  ARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNV 437
                P G +                      ID+     + C    C   P  Y C C  
Sbjct: 354  LCTCPRGYEL--------------DTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYA 399

Query: 438  GYTQDVRG-ECIDVDECTSSP--CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECI 494
            GY     G  C DVDEC SS   C H  C N+ G++ C C  G++    R+ C  ++E +
Sbjct: 400  GYRLSADGCGCEDVDECASSRGGCEH-HCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPM 458

Query: 495  VS-GGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSF 553
            V   G     R +      Q      F+    G +  +       T+    VCL++    
Sbjct: 459  VDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGH 518

Query: 554  SC--LCKPGFLLAPGGHYCMDIDECQTP----GICVNGHC-TNTEG---SFRCQCLGG-- 601
             C   C        GG   + +D C  P    G+  N  C  +T G   SF C C  G  
Sbjct: 519  DCSLTCDD---CRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGT 575

Query: 602  ---------LAVGTDGRVCVD--------THVRSTCYGAIEKGSCARPF------PGTVT 638
                        G  G  C D         H R  C     +G C R +      PG   
Sbjct: 576  CDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKC-NCANRGRCHRLYGACLCDPGLYG 634

Query: 639  KSECCCANPDHGFGEPC-----------QLCPAKDSAEFQALCSSGLGITTDGRDINECA 687
            +  C    P   FG  C           Q C  +D +     CS   G   + R   EC 
Sbjct: 635  RF-CHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGS-----CSCKAGFRGE-RCQAECE 687

Query: 688  L--------DPEVCANGV-CENLRGSYRCVCNLGYEAGASGKDC---TDVDECALNSLLC 735
            L            C  GV C+++ G     C  G++    G++C   T    C+ +S  C
Sbjct: 688  LGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCS-SSCSC 746

Query: 736  DNGWCQNSPGSYSCSCPPGFHFWQDTEI-CKDVDECLSSPCVSGVCRNLA----GSYTCK 790
                C    G   C CPPG    +D E  C +    L    +   C++ A     +  C 
Sbjct: 747  GGAPCHGVTG--QCRCPPG-RTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACL 803

Query: 791  CGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAW-GSPCERC 849
            C PG      G+ C D      +    ++RC     G    +    +    W G  C+R 
Sbjct: 804  CLPGF----VGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQR- 858

Query: 850  EIDPACARGFARMTGVTCDDVNECESFPGVCP--NGRCVNTAGSF--RCE--CPEGLMLD 903
                AC  G     G  C     C +  G C   +G C+  AG    RCE  CP+G    
Sbjct: 859  ----ACDTGH---WGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGP 911

Query: 904  ASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVC--CCSIGAVWGVEC-EAC-----P 955
               + C       C    D      T P  +R   C   C  G  +G++C  AC      
Sbjct: 912  GCEQRCQCQHGAAC----DHVSGACTCPAGWRGTFCEHACPAG-FFGLDCRSACNCTAGA 966

Query: 956  DPESLEFASLCPRG-LGFASRDFLSGRPFYKDVNE-CKVFPGLCTHGTCRNTVGSFHCA- 1012
              +++  + LCP G  G    +      +  + ++ C  F G     +C    G  HCA 
Sbjct: 967  ACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNG----ASCDPVHGQCHCAP 1022

Query: 1013 -CAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMD 1071
               G   L A        D CR S      GTC   P S  C C  G+ +G    K C+ 
Sbjct: 1023 GWMGPSCLQACPAGLYG-DNCRHSCLCQNGGTC--DPVSGHCACPEGW-AGLACEKECLP 1078

Query: 1072 VD---ECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACED------IDECSLSDG 1122
             D    C        GG C    G  +C CP G      G  C+         E      
Sbjct: 1079 RDVRAGCRHSGGCLNGGLCDPHTG--RCLCPAGW----TGDKCQSPCLRGWFGEACAQRC 1132

Query: 1123 LCPHG-QCVNVIGAFQCSCHAGFQSTPDRQG---------CVDINECRVQNGGCDVHCIN 1172
             CP G  C +V GA  C C  GF  +   Q          C  + +C  +N  C      
Sbjct: 1133 SCPPGAACHHVTGA--CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACH----- 1185

Query: 1173 TEGSYRCSCGQGY------SLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDG 1226
               +  CSC  GY         P GR       CE+     + G C    G   C C  G
Sbjct: 1186 -PATGTCSCAAGYHGPSCQQRCPPGRYGPG---CEQLCGCLNGGSCDAATGA--CRCPTG 1239

Query: 1227 FMATPDMRTCVDVDECDLNPHICLHGD---CENTKGSFVC-------HCQLGYMVRKGAT 1276
            F+ T    TC          H+C  G    C+   G+ +C        C+ G    +   
Sbjct: 1240 FLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGV 1299

Query: 1277 GCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD-----------GFECHDLDEC 1325
            GC     C  GG     HAS      + SC C  GW G            G  CH L+  
Sbjct: 1300 GCEHTCSCRNGGL---CHAS------NGSCSCGLGWTGRHCELACPPGRYGAACH-LECS 1349

Query: 1326 VSQEHRCSP-RGDCLNVPGSYRCTCRQ----GFAGDGFFCEDRDECAENVDLCD--NGQC 1378
                  C P  G C   PG Y   C      GF G G  C+    C      CD  +G+C
Sbjct: 1350 CHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAG--CQGLCWCQHGAP-CDPISGRC 1406

Query: 1379 LNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLC--AFGSCENLPGMFRCICNGGYEL 1436
            L   G +   CE G +P      C    +C  G  C    G C   PG     CN     
Sbjct: 1407 LCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRR 1466

Query: 1437 DRGGGNCTDINECADPVNC--INGVC 1460
             + G +CT   +C    +C  ++G C
Sbjct: 1467 GQFGPSCTLHCDCGGGADCDPVSGQC 1492



 Score =  157 bits (398), Expect = 1e-37
 Identities = 196/776 (25%), Positives = 256/776 (32%), Gaps = 149/776 (19%)

Query: 1956 CPPGFQVQSDH--CIDIDECSEEPNLCLFG-TCTNSPGSFQ-CLCPPGFVLSDNGHRC-F 2010
            C  G+  Q D   C+   ECS   +LC  G  C   PGS Q C CPPGF     G RC +
Sbjct: 110  CCRGWMQQPDEEGCLSA-ECSA--SLCFHGGRCV--PGSAQPCHCPPGF----QGPRCQY 160

Query: 2011 DTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPF 2070
            D  +     R   G C   +  NT  +  C  K PG         C              
Sbjct: 161  DVDEC----RTHNGGCQ-HRCVNTPGSYLCECK-PGFRLHTDSRTCLA------------ 202

Query: 2071 GHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDEC 2130
                          +N CA   G C +     T    RC+C  G+ L   G +CV    C
Sbjct: 203  --------------INSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPC 248

Query: 2131 SVGHPCGQGTCTNVIGGFECACADGFEPGLM-MTCEDIDECSLNPLLCAFRCHNTEGSYL 2189
            +  +      C  V G   C C  G++       CED+DEC+     CA  C NT+GS+ 
Sbjct: 249  ANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFK 308

Query: 2190 CTCPAGYTLREDGAMC-----RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLP 2244
            C C AGY L  DG  C       V+ C      C      C +      C CP G   L 
Sbjct: 309  CVCHAGYELGADGRQCYRIEMEIVNSCEANNGGC---SHGCSHTSAGPLCTCPRGYE-LD 364

Query: 2245 GSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEV 2304
                 C D ++C   P  C    C N  G + C C  G++ S     C D+ +       
Sbjct: 365  TDQRTCIDVDDCADSP--CCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGG 422

Query: 2305 LQTMCRSLSSSSEAVTRAECCCGGG-------RGWGPRCE-LCPLPGTSAYRKLCPHGSG 2356
             +  C +L+ S       +C C  G       RG  P  E +  L G   + +  PH + 
Sbjct: 423  CEHHCTNLAGS------FQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAV 476

Query: 2357 YTAE----------GRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDM 2406
               E          G D +E  +        + +    SF   C           TCL  
Sbjct: 477  LQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCL-- 534

Query: 2407 DECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVG 2466
                              G   C CP G+     G  C +     +   NC F C    G
Sbjct: 535  -----------------LGLDGCDCPEGW----TGLICNETCPPDTFGKNCSFSCSCQNG 573

Query: 2467 AF------TCRCPPGF--TQHHQAC---FDNDECSAQPGPCGAHGHCHNTPGSFRCE--- 2512
                     CRCPPG   T     C   +    C  +   C   G CH   G+  C+   
Sbjct: 574  GTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCN-CANRGRCHRLYGACLCDPGL 632

Query: 2513 ----CHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVD 2568
                CH      + G GC +  +C  PH     C  + G   CSC  GF    +  +C  
Sbjct: 633  YGRFCHLTCPPWAFGPGCSEECQCVQPH--TQSCDKRDGS--CSCKAGF----RGERCQA 684

Query: 2569 ENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSC--- 2625
            E E     P C  A          C CP G   D   G C +      +   C   C   
Sbjct: 685  ECELGYFGPGCWQA----------CTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVG 734

Query: 2626 ---ANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPD-KEELLSSEACYECK 2677
                N      CG    +   GQ  C  G        D P+ +  L   E C  C+
Sbjct: 735  TFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQ 790



 Score =  122 bits (305), Expect = 6e-27
 Identities = 199/764 (26%), Positives = 237/764 (31%), Gaps = 182/764 (23%)

Query: 65   HAYCCPGWRTFPGRSQCVV----PICRRAC----GEGFCSQ-PNLCTCADGTLAPSCGVS 115
            H  C PGW  F  +  C      P C   C    G G C     LC C  G + P C   
Sbjct: 844  HCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQ 903

Query: 116  -----RGSGCS--VSCMNGGTCRGAS--CLCQKGYTGTVCGQPICDRG-----------C 155
                  G GC     C +G  C   S  C C  G+ GT C +  C  G           C
Sbjct: 904  CPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFC-EHACPAGFFGLDCRSACNC 962

Query: 156  HNGGRCIGPN-RCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATV 214
              G  C   N  C C  G  GP+C               E C     G  C++A  C   
Sbjct: 963  TAGAACDAVNGSCLCPAGRRGPRC--------------AETCPAHTYGHNCSQACACFN- 1007

Query: 215  GRAWGLPCELCPAQPHPCRRGFIPNIHTGACQD---VDECQAVPGLCQ-GGSCVNMVGSF 270
                G  C+    Q H C  G++      AC      D C+    LCQ GG+C  + G  
Sbjct: 1008 ----GASCDPVHGQCH-CAPGWMGPSCLQACPAGLYGDNCRH-SCLCQNGGTCDPVSG-- 1059

Query: 271  HCRCPVGHRLSDSSAACE------DYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRC 324
            HC CP G     +  ACE      D RAG   S   GG   G L   +T R C C  G  
Sbjct: 1060 HCACPEGW----AGLACEKECLPRDVRAGCRHS---GGCLNGGLCDPHTGR-CLCPAG-- 1109

Query: 325  WAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG 384
            W        C  RG   F + CAQR    PG                    G  R  P  
Sbjct: 1110 WTGDKCQSPC-LRG--WFGEACAQRCSCPPG-------------AACHHVTGACRCPPGF 1153

Query: 385  SDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVR 444
            + +    +  PG+     A + Q           C        P++  C C  GY     
Sbjct: 1154 TGSGCEQACPPGSFGEDCAQMCQ-----------CPGENPACHPATGTCSCAAGY----- 1197

Query: 445  GECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCH--L 502
                          H   C         RC PG       Q C     C+ +GG C    
Sbjct: 1198 --------------HGPSCQQ-------RCPPGRYGPGCEQLC----GCL-NGGSCDAAT 1231

Query: 503  GRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMC--VNGVCLNEDGSFSCLCKPG 560
            G C    G     CN        G NC     C     C  V G CL   G     C+ G
Sbjct: 1232 GACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERG 1291

Query: 561  FLLAPGGHYCMDIDECQTPGIC--VNGHCTNTEGSFRCQCLGGLAVGTDGRVC---VDTH 615
                  G  C     C+  G+C   NG C+   G     C      G  G  C      H
Sbjct: 1292 CPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCH 1351

Query: 616  VRSTC-------------YGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQ------ 656
              STC             YG   +  C   F G   +  C C +     G PC       
Sbjct: 1352 NNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQH-----GAPCDPISGRC 1406

Query: 657  LCPAKDSAEFQALCSSGLGITTDGRDINE-CALD---PEVCANGVCENLRGSYRCVCNLG 712
            LCPA     F   C  G    + G   ++ C  D   P     G+C    G     CNL 
Sbjct: 1407 LCPAGFHGHF---CERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLD 1463

Query: 713  YEAGASGKDCTDVDECALNSLLCD-NGWCQNSPGSYSCSCPPGF 755
               G  G  CT         L CD  G     P S  C C  G+
Sbjct: 1464 CRRGQFGPSCT---------LHCDCGGGADCDPVSGQCHCVDGY 1498



 Score =  120 bits (301), Expect = 2e-26
 Identities = 267/1136 (23%), Positives = 354/1136 (31%), Gaps = 284/1136 (25%)

Query: 81   CVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRG--ASCLCQ 138
            C++ +    C EG+       TC   T   +C  S       SC NGGTC     +C C 
Sbjct: 533  CLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFS------CSCQNGGTCDSVTGACRCP 586

Query: 139  KGYTGTVC-----------------------------GQPICD----------------- 152
             G +GT C                             G  +CD                 
Sbjct: 587  PGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAF 646

Query: 153  -RGCHNGGRCIGPN---------RCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTG 202
              GC    +C+ P+          C+C  GF G +C+ +       G  GP GC    T 
Sbjct: 647  GPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECE----LGYFGP-GCWQACT- 700

Query: 203  LVCTKALCCATVGRAWGLPCELCPA--QPHPCRRGFIPNIHTGACQDVDECQAVPGLCQG 260
              C   + C +V    G   + CPA  Q   C  G    + T        C      C G
Sbjct: 701  --CPVGVACDSVSGECG---KRCPAGFQGEDC--GQECPVGTFGVNCSSSCS-----CGG 748

Query: 261  GSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAG-----ACFSVLFGGRCAGDLAGHYTRR 315
              C  + G   CRCP G    D  A C + R G      C +     RC  +        
Sbjct: 749  APCHGVTG--QCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGA----- 801

Query: 316  QCCCDRGRCWAAGPVPELCPP---RGSNEFQQLCAQRLPLLP--GHPGLFPGLLGFGSNG 370
             C C  G  +      ++CP      S + +  CA      P  GH    PG  GF    
Sbjct: 802  -CLCLPG--FVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQR 858

Query: 371  MGPP--LGPARLNPHGSDARGIPSLGPGNSN-IGTATLNQTIDICRHFTNLCLNGRCLPT 427
                   GP   +P    A      G G+ + I    L +   +       C  G   P 
Sbjct: 859  ACDTGHWGPDCSHPCNCSA------GHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGP- 911

Query: 428  PSSYRCECNVGYTQD-VRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQA 486
                RC+C  G   D V G C        + C H             C  GF     R A
Sbjct: 912  GCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHA------------CPAGFFGLDCRSA 959

Query: 487  CVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDH---NECATSTMCVN 543
            C     C           C    GS  C+C AG       + C  H   + C+ +  C N
Sbjct: 960  C----NCTAGAA------CDAVNGS--CLCPAGRRGPRCAETCPAHTYGHNCSQACACFN 1007

Query: 544  GV-CLNEDGSFSCLCKPGFL------LAPGGHY---CMDIDECQTPGIC--VNGHCTNTE 591
            G  C    G   C C PG++        P G Y   C     CQ  G C  V+GHC   E
Sbjct: 1008 GASCDPVHG--QCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPE 1065

Query: 592  GSFRCQCLGGLAVGTDGRVCVDTHVRSTC--YGAIEKGSCARPFPGTVTKSECCCANPDH 649
            G        GLA   +   C+   VR+ C   G    G    P  G      C C  P  
Sbjct: 1066 G------WAGLACEKE---CLPRDVRAGCRHSGGCLNGGLCDPHTG-----RCLC--PAG 1109

Query: 650  GFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCV- 708
              G+ CQ    +    F   C+              C+  P       C ++ G+ RC  
Sbjct: 1110 WTGDKCQSPCLR--GWFGEACA------------QRCSCPP----GAACHHVTGACRCPP 1151

Query: 709  ------CNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTE 762
                  C      G+ G+DC  + +C   +  C        P + +CSC  G+H     +
Sbjct: 1152 GFTGSGCEQACPPGSFGEDCAQMCQCPGENPAC-------HPATGTCSCAAGYHGPSCQQ 1204

Query: 763  ICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822
             C         P    +C  L G  +C    G+   P+G    D              C 
Sbjct: 1205 RC---PPGRYGPGCEQLCGCLNGG-SCDAATGACRCPTGFLGTD--------------CN 1246

Query: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPN 882
            +          C    G   G+ C+       C  G A   GV C+           CP 
Sbjct: 1247 LTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRA---GVRCE---------RGCPQ 1294

Query: 883  GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTL-PGKYRMDVCCC 941
             R         C C  G +  AS   C       C L W    C +   PG+Y       
Sbjct: 1295 NR-FGVGCEHTCSCRNGGLCHASNGSC------SCGLGWTGRHCELACPPGRY------- 1340

Query: 942  SIGAVWGVECEACPDPESLEFAS-LCPRGLGFASRDFLSGRPFYKDVNECKVFPGL---- 996
              GA   +EC +C +  + E A+  C  G G           FY    E    PG     
Sbjct: 1341 --GAACHLEC-SCHNNSTCEPATGTCRCGPG-----------FYGQACEHPCPPGFHGAG 1386

Query: 997  ------CTHGTCRNTVGSFHCACAGGFALDAQERNC---TDIDECRISPDLCGQGTCVNT 1047
                  C HG   + + S  C C  GF     ER C   +  + C    D  G   C   
Sbjct: 1387 CQGLCWCQHGAPCDPI-SGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPC--D 1443

Query: 1048 PGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDG-SYKCQCPPGH 1102
            P +  C C PG  SG     +C          L C  G   + D  S +C C  G+
Sbjct: 1444 PVTGLCLCPPG-RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGY 1498



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 74/278 (26%), Positives = 92/278 (33%), Gaps = 71/278 (25%)

Query: 68  CCPGWRTFPGRSQCVVPICRRACGEGFCSQP--------NLCTCADGTLAPSCG------ 113
           C PG+R       C+  I   A G G C           + C C  G      G      
Sbjct: 187 CKPGFRLHTDSRTCLA-INSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRR 245

Query: 114 ---VSRGSGCSVSCMNGGTCRG-ASCLCQKGYT----GTVC--------GQPICDRGCHN 157
               +R   C   C      RG A C C  GY     G  C        G   C  GC N
Sbjct: 246 SPCANRNGSCMHRCQ---VVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLN 302

Query: 158 GGRCIGPNRCACVYGFM----GPQCER---------DYRTGPCFGQVGPEGCQHQLTGLV 204
                G  +C C  G+     G QC R         +   G C       GC H   G +
Sbjct: 303 TQ---GSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGC-----SHGCSHTSAGPL 354

Query: 205 CT---------KALCCATVGRAWGLPC--ELCPAQPHP----CRRGFIPNIHTGACQDVD 249
           CT             C  V      PC  ++C   P      C  G+  +     C+DVD
Sbjct: 355 CTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVD 414

Query: 250 ECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287
           EC +  G C+   C N+ GSF C C  G+RL +    C
Sbjct: 415 ECASSRGGCEH-HCTNLAGSFQCSCEAGYRLHEDRRGC 451



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 53/187 (28%), Positives = 65/187 (34%), Gaps = 33/187 (17%)

Query: 18   LAWSALLC-MAGGQGRWDGA--LEAAGPGRVRRRGSPGILQ-GPNVCGSRFHAYCCPGWR 73
            L W+   C +A   GR+  A  LE +         + G  + GP   G      C PG+ 
Sbjct: 1324 LGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFH 1383

Query: 74   TFPGRSQCVVPICRRACGEGFCSQP--NLCTCADGTLAPSCGV-----SRGSGCS--VSC 124
                +  C        C  G    P    C C  G     C       S G GC     C
Sbjct: 1384 GAGCQGLCW-------CQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDC 1436

Query: 125  MNGGTCRGAS--CLCQKGYTGTVC------GQ--PICDRGCH-NGGRCIGP--NRCACVY 171
              G  C   +  CLC  G +G  C      GQ  P C   C   GG    P   +C CV 
Sbjct: 1437 DGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVD 1496

Query: 172  GFMGPQC 178
            G+MGP C
Sbjct: 1497 GYMGPTC 1503


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  290 bits (742), Expect = 1e-77
 Identities = 158/429 (36%), Positives = 215/429 (50%), Gaps = 25/429 (5%)

Query: 990  CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPG 1049
            C      C H  C N  GS+ C C  G+ L++ +  C   D C +    C Q  CVN PG
Sbjct: 242  CSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299

Query: 1050 SFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTA 1106
            SF C+C+ GY   E G    K C+ VD CA +   C    C N DGSY CQC  G  L  
Sbjct: 300  SFVCQCYSGYALAEDG----KRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNP 354

Query: 1107 KGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGC 1166
                C  ID C+ S+  C H +CVN   ++ C C  GF   PD++ C  IN C +   GC
Sbjct: 355  DKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413

Query: 1167 DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDG 1226
            +  C+N E SY C C +GY+L P+G+ C+ VD C +    C+Q  C N      C C +G
Sbjct: 414  EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEG 472

Query: 1227 FMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEV 1286
            F+   D++TC  VD C L+ H C +  C N   SF C C  G+++R     C+ +D C +
Sbjct: 473  FLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCAL 531

Query: 1287 GGHNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGS 1344
            G H C+   SC++   SF C+C  G++   DG  C   D C + +H C     C+N   S
Sbjct: 532  GDHGCEH--SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDS 587

Query: 1345 YRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402
            Y C C +GF  A DG  C  +D C      C++  C+N    Y C+C  GF   ED R C
Sbjct: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRC 646

Query: 1403 QDVDECAQG 1411
            +   +C +G
Sbjct: 647  K---KCTEG 652



 Score =  216 bits (551), Expect = 2e-55
 Identities = 136/447 (30%), Positives = 184/447 (41%), Gaps = 40/447 (8%)

Query: 2170 CSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
            CS     CA  C N  GSY+C C  GY L  D   CR  D CA    +C      C N+ 
Sbjct: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL---CVNVP 298

Query: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
            G+F C C  G   L   G+ C   + C ++   C +  CVN  GS+ C C EGF  +P  
Sbjct: 299  GSFVCQCYSGYA-LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDK 356

Query: 2290 TECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRK 2349
              C  I          Q  C +   S        C C  G    P  + C          
Sbjct: 357  KTCTKIDYCASSNHGCQHECVNTDDSYS------CHCLKGFTLNPDKKTC---------- 400

Query: 2350 LCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
                        R ++ C +    C H EC+N   S+ C C  GYT D    TC  +D C
Sbjct: 401  ------------RRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447

Query: 2410 SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469
            +Q    C  LC NT+ SF+C C  G+L+ ED +TC  +D C    H C++ CVN   +F 
Sbjct: 448  AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507

Query: 2470 CRCPPG--FTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527
            C+CP G       + C   D C+   G  G    C ++  SF C+C +G+ L   G  C 
Sbjct: 508  CQCPEGHVLRSDGKTCAKLDSCAL--GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565

Query: 2528 DVNECDG-PHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRN 2586
              + C    H C+H C N    Y C C +GF       +C  ++ C  +   C    C N
Sbjct: 566  RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVN 624

Query: 2587 TLGGFRCVCPSGFDFDQALGGCQEVDE 2613
                + C C  GF   +    C++  E
Sbjct: 625  NGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  205 bits (521), Expect = 6e-52
 Identities = 131/421 (31%), Positives = 189/421 (44%), Gaps = 33/421 (7%)

Query: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301
            C    H C H  C N  GS+VC C+ GY++    T C   D C +  HNC+    C+N+P
Sbjct: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVP 298

Query: 1302 GSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDG 1357
            GSF C+C  G+    DG  C  +D C S+ H C    +C+N  GSY C C +GFA   D 
Sbjct: 299  GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDK 356

Query: 1358 FFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG 1417
              C   D CA +   C + +C+N    Y C C  GF    D + C+ ++ CA        
Sbjct: 357  KTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH 415

Query: 1418 SCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477
             C N+   + C C+ GY LD  G  C+ ++ CA   +    +C+NT  S++C C + F +
Sbjct: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475

Query: 1478 NPSGVGCVDTRAGNCFLETHD------RGDSGISCSAEIG-----VGVTRASC-CCSLGR 1525
            N     C  +R   C L  H         D   +C    G      G T A    C+LG 
Sbjct: 476  NEDLKTC--SRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG- 532

Query: 1526 AWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGS 1585
               + CE   +++   +   C  G   + +  T   +D+  CQ +   C+   CVN+  S
Sbjct: 533  --DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV--CQAIDHGCE-HICVNSDDS 587

Query: 1586 FQCECPPGYHLSEHTRICEDIDEC-STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644
            + CEC  G+ L+E  + C   D C STH G      C N   +Y C C   ++    G  
Sbjct: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICKCSEGFVLAEDGRR 645

Query: 1645 C 1645
            C
Sbjct: 646  C 646



 Score =  198 bits (503), Expect = 7e-50
 Identities = 130/408 (31%), Positives = 173/408 (42%), Gaps = 43/408 (10%)

Query: 410 DICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSP--CHHGDCVNI 466
           D+C    + C    C+  P S+ C+C  GY     G+ C+ VD C S    C H +CVN 
Sbjct: 281 DLCAMEDHNC-EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNA 338

Query: 467 PGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDG 526
            G+Y C+C+ GF   P ++ C  +D C  S   C    CVNT+ S+ C C  GF L+PD 
Sbjct: 339 DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQ-HECVNTDDSYSCHCLKGFTLNPDK 397

Query: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586
           K C   N CA +       C+N + S+ C C  G+ L P G  C  +D C          
Sbjct: 398 KTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL 457

Query: 587 CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
           C NTE SF CQC  G  +  D + C         Y  +    C           E  C N
Sbjct: 458 CLNTEDSFVCQCSEGFLINEDLKTC-----SRVDYCLLSDHGC-----------EYSCVN 501

Query: 647 PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRG 703
            D  F   CQ             C  G  + +DG+    ++ CAL    C +  C +   
Sbjct: 502 MDRSFA--CQ-------------CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSED 545

Query: 704 SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763
           S+ C C  GY     GK C   D C      C++  C NS  SY+C C  GF   +D + 
Sbjct: 546 SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKR 604

Query: 764 CKDVDECLSS-PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKG 810
           C+  D C S+      +C N   SY CKC  G  L   G  C   T+G
Sbjct: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652



 Score =  197 bits (500), Expect = 2e-49
 Identities = 110/314 (35%), Positives = 142/314 (45%), Gaps = 8/314 (2%)

Query: 2367 CRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGS 2426
            C  L H CAH  CIN  GS+ C C+ GY  ++  TTC   D C+     C  LC N  GS
Sbjct: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQH--HQACF 2484
            F+C C  GY L EDG+ C  +D C S  H C+  CVN  G++ C+C  GF  +   + C 
Sbjct: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360

Query: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQ 2543
              D C++    C     C NT  S+ C C +GFTL      C  +N C      C+H C 
Sbjct: 361  KIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418

Query: 2544 NQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQ 2603
            N    Y C C +G+T       C   + CA     C    C NT   F C C  GF  ++
Sbjct: 419  NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL-CLNTEDSFVCQCSEGFLINE 477

Query: 2604 ALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPD 2663
             L  C  VD C      C YSC N    F C CP+G+     G   + L  S    D   
Sbjct: 478  DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD-SCALGDHGC 536

Query: 2664 KEELLSSEACYECK 2677
            +   +SSE  + C+
Sbjct: 537  EHSCVSSEDSFVCQ 550



 Score =  190 bits (483), Expect = 1e-47
 Identities = 136/454 (29%), Positives = 188/454 (41%), Gaps = 52/454 (11%)

Query: 1711 LTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
            LT +   K      C  +   CA+  CIN  GS+ C C  G+  NS    C   D C   
Sbjct: 228  LTSVFQKKLCTAHMCSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME 286

Query: 1771 ESPCQQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYM 1829
            +  C+Q   C+N+PGS+ C+C  GY L+  G  CV  + C    + C H +C++ +GSY+
Sbjct: 287  DHNCEQL--CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYL 343

Query: 1830 CLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVT-HNGDCVDF 1887
            C CH GF  + D+  C  ID C     G    C N   SY+C C  GF +      C   
Sbjct: 344  CQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI 403

Query: 1888 DECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQN 1947
            + C  L    C    C+N   S++C C  G+ L  +GK C   + C      C    C N
Sbjct: 404  NYC-ALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLN 460

Query: 1948 LEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDN 2005
             E SF C C  GF +  D   C  +D C    + C + +C N   SF C CP G VL  +
Sbjct: 461  TEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSD 519

Query: 2006 GHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQ 2065
            G  C                          K   C     G      CE        +F 
Sbjct: 520  GKTC-------------------------AKLDSCALGDHG------CEHSCVSSEDSF- 547

Query: 2066 ELCPFGHGAV---PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGI 2122
             +C    G +    G    R+DV +  ++   C + +CVN+D S+ CEC  G+ L   G 
Sbjct: 548  -VCQCFEGYILREDGKTCRRKDVCQAIDHG--CEH-ICVNSDDSYTCECLEGFRLAEDGK 603

Query: 2123 NCVDTDECSVGHPCGQGTCTNVIGGFECACADGF 2156
             C   D C   H   +  C N    + C C++GF
Sbjct: 604  RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGF 637



 Score =  188 bits (477), Expect = 7e-47
 Identities = 114/428 (26%), Positives = 170/428 (39%), Gaps = 43/428 (10%)

Query: 2225 CKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQ 2284
            C N+ G++ C C  G   L      C   + C  +   C    CVN  GSF C C  G+ 
Sbjct: 253  CINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGY- 309

Query: 2285 PSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGT 2344
                                      +L+   +     + C     G    CE   +   
Sbjct: 310  --------------------------ALAEDGKRCVAVDYCASENHG----CEHECVNAD 339

Query: 2345 SAYRKLCPHGSGYTAEGRD---VDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATAT 2401
             +Y   C  G     + +    +D C    H C H EC+N+  S+ CHC  G+T +    
Sbjct: 340  GSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKK 398

Query: 2402 TCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLC 2461
            TC  ++ C+     C   C N + S+ C C RGY L+ +G+TC  +D C  + H C+ LC
Sbjct: 399  TCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC 458

Query: 2462 VNTVGAFTCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTL 2519
            +NT  +F C+C  GF   +  + C   D C      C     C N   SF C+C +G  L
Sbjct: 459  LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFACQCPEGHVL 516

Query: 2520 VSSGHGCEDVNECD-GPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPT 2578
             S G  C  ++ C  G H C+H C +    + C C +G+        C  ++ C      
Sbjct: 517  RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHG 576

Query: 2579 CGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQ 2638
            C    C N+   + C C  GF   +    C+  D C      C + C N    ++C C +
Sbjct: 577  CEHI-CVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSE 635

Query: 2639 GYFRAGQG 2646
            G+  A  G
Sbjct: 636  GFVLAEDG 643



 Score =  182 bits (463), Expect = 3e-45
 Identities = 131/419 (31%), Positives = 173/419 (41%), Gaps = 46/419 (10%)

Query: 463 CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
           C+NIPG+Y CRC  G+     +  C   D C +    C    CVN  GSF C C +G+ L
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 523 SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGIC 582
           + DGK CV  + CA+        C+N DGS+ C C  GF L P    C  ID C +    
Sbjct: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371

Query: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSEC 642
               C NT+ S+ C CL G  +  D + C     R   Y A+ K  C            C
Sbjct: 372 CQHECVNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNKPGCEHECVNMEESYYC 426

Query: 643 -C------------------CANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD- 682
            C                  CA  DHG    C+         F   CS G  I  D +  
Sbjct: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFVCQCSEGFLINEDLKTC 482

Query: 683 --INECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWC 740
             ++ C L    C    C N+  S+ C C  G+   + GK C  +D CAL    C++  C
Sbjct: 483 SRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-C 540

Query: 741 QNSPGSYSCSCPPGFHFWQDTEIC--KDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD 798
            +S  S+ C C  G+   +D + C  KDV + +   C   +C N   SYTC+C  G RL 
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCECLEGFRLA 599

Query: 799 PSGTFCLDSTKGTCWLKIQESRCE---VNLQGASLRSECC-ATLGAAWGSPCERCEIDP 853
             G  C    K  C  K     CE   VN  G S   +C    + A  G  C++C   P
Sbjct: 600 EDGKRC--RRKDVC--KSTHHGCEHICVN-NGNSYICKCSEGFVLAEDGRRCKKCTEGP 653



 Score =  181 bits (458), Expect = 1e-44
 Identities = 134/465 (28%), Positives = 196/465 (42%), Gaps = 65/465 (13%)

Query: 1767 CGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGD------ 1820
            C + E  C     CINIPGSY C+C +GY L+       +  CR I ++C+  D      
Sbjct: 242  CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSD-----QTTCR-IQDLCAMEDHNCEQL 293

Query: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVT 1879
            C++  GS++C C+ G+  + D   C+ +D C  +  G    C N  GSY C C  GF + 
Sbjct: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 1880 HNGD-CVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG 1938
             +   C   D C +     C+   C+NT  S+ C C  GF L  D K C   N C     
Sbjct: 354  PDKKTCTKIDYCASS-NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKP 411

Query: 1939 TCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSPGSFQCLC 1996
             C    C N+E S+ C C  G+ +  +   C  +D C+++ + C    C N+  SF C C
Sbjct: 412  GC-EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQC 469

Query: 1997 PPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELC 2056
              GF+++++   C  +R  +C                                   CE  
Sbjct: 470  SEGFLINEDLKTC--SRVDYCLLSDHG-----------------------------CEYS 498

Query: 2057 PQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYS 2116
                  +F   CP GH  +     +   ++ CA     C +  CV+++ SF C+C  GY 
Sbjct: 499  CVNMDRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYI 556

Query: 2117 LDFTGINCVDTDEC-SVGHPCGQGTCTNVIGGFECACADGF---EPGLMMTCEDIDECSL 2172
            L   G  C   D C ++ H C +  C N    + C C +GF   E G    C   D C  
Sbjct: 557  LREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDG--KRCRRKDVCKS 613

Query: 2173 NPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
                C   C N   SY+C C  G+ L EDG  C+   +C +G  D
Sbjct: 614  THHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGPID 655



 Score =  179 bits (453), Expect = 4e-44
 Identities = 129/445 (28%), Positives = 181/445 (40%), Gaps = 50/445 (11%)

Query: 1861 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
            C NI GSY C C  G+++  +       +   +    C    C+N  GSF C C  G+ L
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGSFVCQCYSGYAL 311

Query: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPN 1978
              DGK CV  + C S    C    C N +GS+ C C  GF +  D   C  ID C+   +
Sbjct: 312  AEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370

Query: 1979 LCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTR 2038
             C    C N+  S+ C C  GF L+ +   C                          +  
Sbjct: 371  GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC-------------------------RRIN 404

Query: 2039 CCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVP-GPDDSREDVNECAENPGVCTN 2097
             C   +PG      CE        ++   C  G+   P G   SR  V+ CA+    C  
Sbjct: 405  YCALNKPG------CEHECVNMEESYYCRCHRGYTLDPNGKTCSR--VDHCAQQDHGCEQ 456

Query: 2098 GVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGF- 2156
             +C+NT+ SF C+C  G+ ++     C   D C +     + +C N+   F C C +G  
Sbjct: 457  -LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHV 515

Query: 2157 --EPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADG 2214
                G   TC  +D C+L    C   C ++E S++C C  GY LREDG  CR  D C   
Sbjct: 516  LRSDG--KTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI 573

Query: 2215 QQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGS 2274
               C      C N   ++ C C  G R L   G+ C   + C +    C +  CVN   S
Sbjct: 574  DHGCEHI---CVNSDDSYTCECLEGFR-LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNS 628

Query: 2275 FRCDCDEGFQPSPTLTECHDIRQGP 2299
            + C C EGF  +     C    +GP
Sbjct: 629  YICKCSEGFVLAEDGRRCKKCTEGP 653



 Score =  171 bits (434), Expect = 7e-42
 Identities = 122/399 (30%), Positives = 168/399 (42%), Gaps = 47/399 (11%)

Query: 1890 CTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLE 1949
            C+TL      F  C+N  GS+ C C+ G+ L +D   C   + C      C    C N+ 
Sbjct: 242  CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVP 298

Query: 1950 GSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGH 2007
            GSF C C  G+ +  D   C+ +D C+ E + C    C N+ GS+ C C  GF L+ +  
Sbjct: 299  GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKK 357

Query: 2008 RCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQEL 2067
             C                         TK   C S   G      C+        ++   
Sbjct: 358  TC-------------------------TKIDYCASSNHG------CQHECVNTDDSYSCH 386

Query: 2068 CPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDT 2127
            C  G    P     R  +N CA N   C +  CVN + S+ C C  GY+LD  G  C   
Sbjct: 387  CLKGFTLNPDKKTCRR-INYCALNKPGCEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRV 444

Query: 2128 DECSV-GHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECSLNPLLCAFRCHNTE 2185
            D C+   H C Q  C N    F C C++GF     + TC  +D C L+   C + C N +
Sbjct: 445  DHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD 503

Query: 2186 GSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPG 2245
             S+ C CP G+ LR DG  C  +D CA G   C      C +   +F C C  G   L  
Sbjct: 504  RSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE---HSCVSSEDSFVCQCFEGY-ILRE 559

Query: 2246 SGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQ 2284
             G+ C   + C A    C +  CVN+  S+ C+C EGF+
Sbjct: 560  DGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFR 597



 Score =  167 bits (424), Expect = 1e-40
 Identities = 133/475 (28%), Positives = 189/475 (39%), Gaps = 82/475 (17%)

Query: 739  WCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRL 797
            +C N PGSY C C  G+    D   C+  D C +       +C N+ GS+ C+C  G  L
Sbjct: 252  FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311

Query: 798  DPSGTFCLDSTKGTCWLKIQESRCE---VNLQGASLRSECCATLGAAWGSPCERCEIDPA 854
               G  C+       +   +   CE   VN  G+ L               C+       
Sbjct: 312  AEDGKRCV----AVDYCASENHGCEHECVNADGSYL---------------CQ------- 345

Query: 855  CARGFA-RMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
            C  GFA      TC  ++ C S    C +  CVNT  S+ C C +G  L+   + C  + 
Sbjct: 346  CHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRI- 403

Query: 914  LEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECE-ACPDPESLEFASLCPRGLGF 972
                      + C +  PG                  CE  C + E   +   C RG   
Sbjct: 404  ----------NYCALNKPG------------------CEHECVNMEE-SYYCRCHRGYTL 434

Query: 973  ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDEC 1032
                    R     V+ C      C    C NT  SF C C+ GF ++   + C+ +D C
Sbjct: 435  DPNGKTCSR-----VDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC 488

Query: 1033 RISPDLCGQGTCVNTPGSFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTN 1089
             +S   C + +CVN   SF C+C  G+     G    K C  +D CA     C   +C +
Sbjct: 489  LLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDG----KTCAKLDSCALGDHGCE-HSCVS 542

Query: 1090 TDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPD 1149
            ++ S+ CQC  G+ L   G  C   D C   D  C H  CVN   ++ C C  GF+   D
Sbjct: 543  SEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAED 601

Query: 1150 RQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204
             + C   + C+  + GC+  C+N   SY C C +G+ L  DGR C    +C E P
Sbjct: 602  GKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC---KKCTEGP 653



 Score =  157 bits (398), Expect = 1e-37
 Identities = 120/406 (29%), Positives = 171/406 (42%), Gaps = 47/406 (11%)

Query: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFN 1668
            CST    C    C N  G+Y C C   Y+ +N       ++       +N  C+ +L  N
Sbjct: 242  CSTLEHNCAH-FCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHN--CE-QLCVN 296

Query: 1669 VTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEI 1728
            V     C  Y+ G A     + C   ++ DY   C ++  G                   
Sbjct: 297  VPGSFVCQCYS-GYALAEDGKRC---VAVDY---CASENHG------------------- 330

Query: 1729 PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYR 1788
               C +  C+N  GS+ C+C  GF  N     C  +D C S    CQ   +C+N   SY 
Sbjct: 331  ---CEHE-CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH--ECVNTDDSYS 384

Query: 1789 CKCTRGYKLSPG-GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
            C C +G+ L+P    C   N C      C H +C++ E SY C CHRG+    +   C  
Sbjct: 385  CHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR 443

Query: 1848 IDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVTHN-GDCVDFDECTTLVGQVCRFGHCLN 1905
            +D C +Q  G    C N   S+ C C  GF++  +   C   D C  L    C +  C+N
Sbjct: 444  VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYS-CVN 501

Query: 1906 TAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD 1965
               SF C C +G  L +DGK C   + C +L       +C + E SF C C  G+ ++ D
Sbjct: 502  MDRSFACQCPEGHVLRSDGKTCAKLDSC-ALGDHGCEHSCVSSEDSFVCQCFEGYILRED 560

Query: 1966 --HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC 2009
               C   D C    + C    C NS  S+ C C  GF L+++G RC
Sbjct: 561  GKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605



 Score =  150 bits (378), Expect = 2e-35
 Identities = 115/436 (26%), Positives = 163/436 (37%), Gaps = 57/436 (13%)

Query: 1378 CLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELD 1437
            C+N PG Y C C+ G+    D   C+  D CA  +      C N+PG F C C  GY L 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312

Query: 1438 RGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETH 1497
              G  C  ++ CA   +     C+N  GSYLC C + F LNP    C  T+   C    H
Sbjct: 313  EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYCASSNH 370

Query: 1498 D------RGDSGISCSAEIG--VGVTRASC----CCSLGRAWGNPCELCPMANTTEYRTL 1545
                     D   SC    G  +   + +C     C+L +     CE   +     Y   
Sbjct: 371  GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKP---GCEHECVNMEESYYCR 427

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICED 1605
            C  G    PN  T     +D C +    C+   C+NT  SF C+C  G+ ++E  + C  
Sbjct: 428  CHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484

Query: 1606 IDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNEL 1665
            +D C      C   +C N   ++ C CP  ++  + G  C  +       H    C++  
Sbjct: 485  VDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH---GCEHSC 540

Query: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDEC 1725
              +    +C C    G       + C                               D C
Sbjct: 541  VSSEDSFVCQCFE--GYILREDGKTCRRK----------------------------DVC 570

Query: 1726 GEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785
              I   C + IC+N   S+ CEC  GF        C   D C S    C+    C+N   
Sbjct: 571  QAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICVNNGN 627

Query: 1786 SYRCKCTRGYKLSPGG 1801
            SY CKC+ G+ L+  G
Sbjct: 628  SYICKCSEGFVLAEDG 643



 Score =  147 bits (371), Expect = 1e-34
 Identities = 136/471 (28%), Positives = 182/471 (38%), Gaps = 64/471 (13%)

Query: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586
           K C  H  C+T        C+N  GS+ C CK G++L      C   D C          
Sbjct: 235 KLCTAHM-CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293

Query: 587 CTNTEGSFRCQCLGGLAVGTDGRVCV-------DTH-VRSTCYGA-------IEKGSCAR 631
           C N  GSF CQC  G A+  DG+ CV       + H     C  A         +G    
Sbjct: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECAL 688
           P   T TK +  CA+ +HG    CQ         +   C  G  +  D    R IN CAL
Sbjct: 354 PDKKTCTKID-YCASSNHG----CQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCAL 408

Query: 689 DPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYS 748
           +   C +  C N+  SY C C+ GY    +GK C+ VD CA     C+   C N+  S+ 
Sbjct: 409 NKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFV 466

Query: 749 CSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFC--L 805
           C C  GF   +D + C  VD C LS       C N+  S+ C+C  G  L   G  C  L
Sbjct: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKL 526

Query: 806 DSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF-ARMTG 864
           DS        + +  CE +   +     C                    C  G+  R  G
Sbjct: 527 DS------CALGDHGCEHSCVSSEDSFVC-------------------QCFEGYILREDG 561

Query: 865 VTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDED 924
            TC   + C++    C +  CVN+  S+ CEC EG  L   G+ C   R + C  +    
Sbjct: 562 KTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC--KSTHH 616

Query: 925 ECGVTLPGKYRMDVCCCSIGAVW---GVECEACPD-PESLEFASLCPRGLG 971
            C           +C CS G V    G  C+ C + P  L F     + LG
Sbjct: 617 GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLG 667



 Score =  146 bits (368), Expect = 3e-34
 Identities = 132/499 (26%), Positives = 191/499 (38%), Gaps = 102/499 (20%)

Query: 587  CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
            C N  GS+ C+C  G  + +D   C                           + +  CA 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTC---------------------------RIQDLCAM 285

Query: 647  PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD---INECALDPEVCANGVCENLRG 703
             DH   + C   P      F   C SG  +  DG+    ++ CA +   C +  C N  G
Sbjct: 286  EDHNCEQLCVNVPGS----FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADG 340

Query: 704  SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763
            SY C C+ G+      K CT +D CA ++  C +  C N+  SYSC C  GF    D + 
Sbjct: 341  SYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKT 399

Query: 764  CKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822
            C+ ++ C L+ P     C N+  SY C+C  G  LDP+G  C  S    C    Q+  CE
Sbjct: 400  CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC--SRVDHC--AQQDHGCE 455

Query: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGV-TCDDVNECESFPGVCP 881
                      + C  L       C+       C+ GF     + TC  V+ C      C 
Sbjct: 456  ----------QLC--LNTEDSFVCQ-------CSEGFLINEDLKTCSRVDYCLLSDHGCE 496

Query: 882  NGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCC 941
               CVN   SF C+CPEG +L + G+ C   +L+ C L   +  C  +        VC C
Sbjct: 497  YS-CVNMDRSFACQCPEGHVLRSDGKTC--AKLDSCAL--GDHGCEHSCVSSEDSFVCQC 551

Query: 942  SIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT 1001
              G +   + + C                              KDV  C+     C H  
Sbjct: 552  FEGYILREDGKTCR----------------------------RKDV--CQAIDHGCEH-I 580

Query: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYES 1061
            C N+  S+ C C  GF L    + C   D C+ +   C +  CVN   S+ C+C      
Sbjct: 581  CVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC----SE 635

Query: 1062 GFMLMKNCMDVDECARDPL 1080
            GF+L ++     +C   P+
Sbjct: 636  GFVLAEDGRRCKKCTEGPI 654



 Score =  137 bits (344), Expect = 2e-31
 Identities = 123/470 (26%), Positives = 170/470 (36%), Gaps = 91/470 (19%)

Query: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC--ED 289
           C++G+I N     C+  D C      C+   CVN+ GSF C+C  G+ L++    C   D
Sbjct: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322

Query: 290 YRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP-----PRGSNEFQQ 344
           Y    C S   G  C  +         C C  G  +A  P  + C         ++  Q 
Sbjct: 323 Y----CASENHG--CEHECVNADGSYLCQCHEG--FALNPDKKTCTKIDYCASSNHGCQH 374

Query: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
            C         H      L GF             LNP     R           I    
Sbjct: 375 ECVNTDDSYSCH-----CLKGF------------TLNPDKKTCR----------RINYCA 407

Query: 405 LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGD- 462
           LN+    C H         C+    SY C C+ GYT D  G+ C  VD C      HG  
Sbjct: 408 LNK--PGCEH--------ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGCE 455

Query: 463 --CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGF 520
             C+N   ++ C+C  GF      + C  VD C++S   C    CVN + SF C C  G 
Sbjct: 456 QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGH 514

Query: 521 ELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPG 580
            L  DGK C   + CA         C++ + SF C C  G++L   G  C   D CQ   
Sbjct: 515 VLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAID 574

Query: 581 ICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKS 640
                 C N++ S+ C+CL G  +  DG+ C                           + 
Sbjct: 575 HGCEHICVNSDDSYTCECLEGFRLAEDGKRC---------------------------RR 607

Query: 641 ECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDP 690
           +  C +  HG    C+     +   +   CS G  +  DGR   +C   P
Sbjct: 608 KDVCKSTHHG----CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653



 Score =  113 bits (283), Expect = 2e-24
 Identities = 105/409 (25%), Positives = 154/409 (37%), Gaps = 63/409 (15%)

Query: 223 ELCPAQPHPCRR-------GFIPNIHTG--------ACQDVDECQAVPGLCQGGSCVNMV 267
           +LC  + H C +        F+   ++G         C  VD C +    C+   CVN  
Sbjct: 281 DLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339

Query: 268 GSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAA 327
           GS+ C+C  G  L+     C   +   C S   G  C  +         C C +G  +  
Sbjct: 340 GSYLCQCHEGFALNPDKKTCT--KIDYCASSNHG--CQHECVNTDDSYSCHCLKG--FTL 393

Query: 328 GPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDA 387
            P  + C  R  N     CA         PG     +    +          L+P+G   
Sbjct: 394 NPDKKTC--RRIN----YCAL------NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441

Query: 388 RGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGY--TQDVRG 445
                                +D C    + C    CL T  S+ C+C+ G+   +D++ 
Sbjct: 442 -------------------SRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFLINEDLK- 480

Query: 446 ECIDVDECTSSPCHHG---DCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHL 502
            C  VD C  S   HG    CVN+  ++ C+C  G       + C  +D C +    C  
Sbjct: 481 TCSRVDYCLLS--DHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE- 537

Query: 503 GRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL 562
             CV++E SF C C  G+ L  DGK C   + C         +C+N D S++C C  GF 
Sbjct: 538 HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFR 597

Query: 563 LAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
           LA  G  C   D C++        C N   S+ C+C  G  +  DGR C
Sbjct: 598 LAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 61/211 (28%), Positives = 74/211 (35%), Gaps = 46/211 (21%)

Query: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGT----- 144
           C EGF   P+  TC   T    C  S   GC   C+N  T    SC C KG+T       
Sbjct: 346 CHEGFALNPDKKTC---TKIDYCA-SSNHGCQHECVN--TDDSYSCHCLKGFTLNPDKKT 399

Query: 145 -------VCGQPICDRGCHNGGRCIGPNRCACVYGF-MGPQCERDYRTGPCFGQVGPEGC 196
                     +P C+  C N         C C  G+ + P  +   R   C  Q    GC
Sbjct: 400 CRRINYCALNKPGCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGC 454

Query: 197 QHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPG 256
           +           LC  T        C+        C  GF+ N     C  VD C     
Sbjct: 455 EQ----------LCLNTED---SFVCQ--------CSEGFLINEDLKTCSRVDYCLLSDH 493

Query: 257 LCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287
            C+  SCVNM  SF C+CP GH L      C
Sbjct: 494 GCEY-SCVNMDRSFACQCPEGHVLRSDGKTC 523



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 66/265 (24%), Positives = 92/265 (34%), Gaps = 47/265 (17%)

Query: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145
           C +GF   P+  TC        C +++  GC   C+N        C C +GYT    G  
Sbjct: 387 CLKGFTLNPDKKTCRRINY---CALNK-PGCEHECVNME--ESYYCRCHRGYTLDPNGKT 440

Query: 146 CGQ-PIC---DRGCHNGGRCIGPNR---CACVYGFM-GPQCERDYRTGPCFGQVGPEGCQ 197
           C +   C   D GC     C+       C C  GF+     +   R   C   +   GC+
Sbjct: 441 CSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL--LSDHGCE 496

Query: 198 HQLTGLVCTKALCCAT--VGRAWGLPC---ELCPAQPHPCRR---------------GFI 237
           +    +  + A  C    V R+ G  C   + C    H C                 G+I
Sbjct: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556

Query: 238 PNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFS 297
                  C+  D CQA+   C+   CVN   S+ C C  G RL++    C   R   C S
Sbjct: 557 LREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCR--RKDVCKS 613

Query: 298 VLFGGRCAGDLAGHYTRRQCCCDRG 322
              G  C      +     C C  G
Sbjct: 614 THHG--CEHICVNNGNSYICKCSEG 636



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 56/219 (25%), Positives = 81/219 (36%), Gaps = 50/219 (22%)

Query: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145
           C EGF    +L TC+       C +S   GC  SC+N    R  +C C +G+     G  
Sbjct: 469 CSEGFLINEDLKTCSR---VDYCLLS-DHGCEYSCVNMD--RSFACQCPEGHVLRSDGKT 522

Query: 146 CGQ----PICDRGCHNGGRCIGPNR---CACVYGFM----GPQCERDYRTGPCFGQVGPE 194
           C +     + D GC +   C+       C C  G++    G  C R      C  Q    
Sbjct: 523 CAKLDSCALGDHGCEHS--CVSSEDSFVCQCFEGYILREDGKTCRRK---DVC--QAIDH 575

Query: 195 GCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAV 254
           GC+H     +C  +    T        CE        C  GF        C+  D C++ 
Sbjct: 576 GCEH-----ICVNSDDSYT--------CE--------CLEGFRLAEDGKRCRRKDVCKST 614

Query: 255 PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAG 293
              C+   CVN   S+ C+C  G  L++    C+    G
Sbjct: 615 HHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  290 bits (742), Expect = 1e-77
 Identities = 158/429 (36%), Positives = 215/429 (50%), Gaps = 25/429 (5%)

Query: 990  CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPG 1049
            C      C H  C N  GS+ C C  G+ L++ +  C   D C +    C Q  CVN PG
Sbjct: 242  CSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299

Query: 1050 SFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTA 1106
            SF C+C+ GY   E G    K C+ VD CA +   C    C N DGSY CQC  G  L  
Sbjct: 300  SFVCQCYSGYALAEDG----KRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNP 354

Query: 1107 KGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGC 1166
                C  ID C+ S+  C H +CVN   ++ C C  GF   PD++ C  IN C +   GC
Sbjct: 355  DKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413

Query: 1167 DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDG 1226
            +  C+N E SY C C +GY+L P+G+ C+ VD C +    C+Q  C N      C C +G
Sbjct: 414  EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEG 472

Query: 1227 FMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEV 1286
            F+   D++TC  VD C L+ H C +  C N   SF C C  G+++R     C+ +D C +
Sbjct: 473  FLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCAL 531

Query: 1287 GGHNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGS 1344
            G H C+   SC++   SF C+C  G++   DG  C   D C + +H C     C+N   S
Sbjct: 532  GDHGCEH--SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDS 587

Query: 1345 YRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402
            Y C C +GF  A DG  C  +D C      C++  C+N    Y C+C  GF   ED R C
Sbjct: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRC 646

Query: 1403 QDVDECAQG 1411
            +   +C +G
Sbjct: 647  K---KCTEG 652



 Score =  216 bits (551), Expect = 2e-55
 Identities = 136/447 (30%), Positives = 184/447 (41%), Gaps = 40/447 (8%)

Query: 2170 CSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
            CS     CA  C N  GSY+C C  GY L  D   CR  D CA    +C      C N+ 
Sbjct: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL---CVNVP 298

Query: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
            G+F C C  G   L   G+ C   + C ++   C +  CVN  GS+ C C EGF  +P  
Sbjct: 299  GSFVCQCYSGYA-LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDK 356

Query: 2290 TECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRK 2349
              C  I          Q  C +   S        C C  G    P  + C          
Sbjct: 357  KTCTKIDYCASSNHGCQHECVNTDDSYS------CHCLKGFTLNPDKKTC---------- 400

Query: 2350 LCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
                        R ++ C +    C H EC+N   S+ C C  GYT D    TC  +D C
Sbjct: 401  ------------RRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447

Query: 2410 SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469
            +Q    C  LC NT+ SF+C C  G+L+ ED +TC  +D C    H C++ CVN   +F 
Sbjct: 448  AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507

Query: 2470 CRCPPG--FTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527
            C+CP G       + C   D C+   G  G    C ++  SF C+C +G+ L   G  C 
Sbjct: 508  CQCPEGHVLRSDGKTCAKLDSCAL--GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565

Query: 2528 DVNECDG-PHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRN 2586
              + C    H C+H C N    Y C C +GF       +C  ++ C  +   C    C N
Sbjct: 566  RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVN 624

Query: 2587 TLGGFRCVCPSGFDFDQALGGCQEVDE 2613
                + C C  GF   +    C++  E
Sbjct: 625  NGNSYICKCSEGFVLAEDGRRCKKCTE 651



 Score =  205 bits (521), Expect = 6e-52
 Identities = 131/421 (31%), Positives = 189/421 (44%), Gaps = 33/421 (7%)

Query: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301
            C    H C H  C N  GS+VC C+ GY++    T C   D C +  HNC+    C+N+P
Sbjct: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVP 298

Query: 1302 GSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDG 1357
            GSF C+C  G+    DG  C  +D C S+ H C    +C+N  GSY C C +GFA   D 
Sbjct: 299  GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDK 356

Query: 1358 FFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG 1417
              C   D CA +   C + +C+N    Y C C  GF    D + C+ ++ CA        
Sbjct: 357  KTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH 415

Query: 1418 SCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477
             C N+   + C C+ GY LD  G  C+ ++ CA   +    +C+NT  S++C C + F +
Sbjct: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475

Query: 1478 NPSGVGCVDTRAGNCFLETHD------RGDSGISCSAEIG-----VGVTRASC-CCSLGR 1525
            N     C  +R   C L  H         D   +C    G      G T A    C+LG 
Sbjct: 476  NEDLKTC--SRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG- 532

Query: 1526 AWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGS 1585
               + CE   +++   +   C  G   + +  T   +D+  CQ +   C+   CVN+  S
Sbjct: 533  --DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV--CQAIDHGCE-HICVNSDDS 587

Query: 1586 FQCECPPGYHLSEHTRICEDIDEC-STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644
            + CEC  G+ L+E  + C   D C STH G      C N   +Y C C   ++    G  
Sbjct: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICKCSEGFVLAEDGRR 645

Query: 1645 C 1645
            C
Sbjct: 646  C 646



 Score =  198 bits (503), Expect = 7e-50
 Identities = 130/408 (31%), Positives = 173/408 (42%), Gaps = 43/408 (10%)

Query: 410 DICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSP--CHHGDCVNI 466
           D+C    + C    C+  P S+ C+C  GY     G+ C+ VD C S    C H +CVN 
Sbjct: 281 DLCAMEDHNC-EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNA 338

Query: 467 PGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDG 526
            G+Y C+C+ GF   P ++ C  +D C  S   C    CVNT+ S+ C C  GF L+PD 
Sbjct: 339 DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQ-HECVNTDDSYSCHCLKGFTLNPDK 397

Query: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586
           K C   N CA +       C+N + S+ C C  G+ L P G  C  +D C          
Sbjct: 398 KTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL 457

Query: 587 CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
           C NTE SF CQC  G  +  D + C         Y  +    C           E  C N
Sbjct: 458 CLNTEDSFVCQCSEGFLINEDLKTC-----SRVDYCLLSDHGC-----------EYSCVN 501

Query: 647 PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRG 703
            D  F   CQ             C  G  + +DG+    ++ CAL    C +  C +   
Sbjct: 502 MDRSFA--CQ-------------CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSED 545

Query: 704 SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763
           S+ C C  GY     GK C   D C      C++  C NS  SY+C C  GF   +D + 
Sbjct: 546 SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKR 604

Query: 764 CKDVDECLSS-PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKG 810
           C+  D C S+      +C N   SY CKC  G  L   G  C   T+G
Sbjct: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652



 Score =  197 bits (500), Expect = 2e-49
 Identities = 110/314 (35%), Positives = 142/314 (45%), Gaps = 8/314 (2%)

Query: 2367 CRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGS 2426
            C  L H CAH  CIN  GS+ C C+ GY  ++  TTC   D C+     C  LC N  GS
Sbjct: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQH--HQACF 2484
            F+C C  GY L EDG+ C  +D C S  H C+  CVN  G++ C+C  GF  +   + C 
Sbjct: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360

Query: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQ 2543
              D C++    C     C NT  S+ C C +GFTL      C  +N C      C+H C 
Sbjct: 361  KIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418

Query: 2544 NQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQ 2603
            N    Y C C +G+T       C   + CA     C    C NT   F C C  GF  ++
Sbjct: 419  NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL-CLNTEDSFVCQCSEGFLINE 477

Query: 2604 ALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPD 2663
             L  C  VD C      C YSC N    F C CP+G+     G   + L  S    D   
Sbjct: 478  DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD-SCALGDHGC 536

Query: 2664 KEELLSSEACYECK 2677
            +   +SSE  + C+
Sbjct: 537  EHSCVSSEDSFVCQ 550



 Score =  190 bits (483), Expect = 1e-47
 Identities = 136/454 (29%), Positives = 188/454 (41%), Gaps = 52/454 (11%)

Query: 1711 LTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
            LT +   K      C  +   CA+  CIN  GS+ C C  G+  NS    C   D C   
Sbjct: 228  LTSVFQKKLCTAHMCSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME 286

Query: 1771 ESPCQQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYM 1829
            +  C+Q   C+N+PGS+ C+C  GY L+  G  CV  + C    + C H +C++ +GSY+
Sbjct: 287  DHNCEQL--CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYL 343

Query: 1830 CLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVT-HNGDCVDF 1887
            C CH GF  + D+  C  ID C     G    C N   SY+C C  GF +      C   
Sbjct: 344  CQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI 403

Query: 1888 DECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQN 1947
            + C  L    C    C+N   S++C C  G+ L  +GK C   + C      C    C N
Sbjct: 404  NYC-ALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLN 460

Query: 1948 LEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDN 2005
             E SF C C  GF +  D   C  +D C    + C + +C N   SF C CP G VL  +
Sbjct: 461  TEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSD 519

Query: 2006 GHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQ 2065
            G  C                          K   C     G      CE        +F 
Sbjct: 520  GKTC-------------------------AKLDSCALGDHG------CEHSCVSSEDSF- 547

Query: 2066 ELCPFGHGAV---PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGI 2122
             +C    G +    G    R+DV +  ++   C + +CVN+D S+ CEC  G+ L   G 
Sbjct: 548  -VCQCFEGYILREDGKTCRRKDVCQAIDHG--CEH-ICVNSDDSYTCECLEGFRLAEDGK 603

Query: 2123 NCVDTDECSVGHPCGQGTCTNVIGGFECACADGF 2156
             C   D C   H   +  C N    + C C++GF
Sbjct: 604  RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGF 637



 Score =  188 bits (477), Expect = 7e-47
 Identities = 114/428 (26%), Positives = 170/428 (39%), Gaps = 43/428 (10%)

Query: 2225 CKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQ 2284
            C N+ G++ C C  G   L      C   + C  +   C    CVN  GSF C C  G+ 
Sbjct: 253  CINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGY- 309

Query: 2285 PSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGT 2344
                                      +L+   +     + C     G    CE   +   
Sbjct: 310  --------------------------ALAEDGKRCVAVDYCASENHG----CEHECVNAD 339

Query: 2345 SAYRKLCPHGSGYTAEGRD---VDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATAT 2401
             +Y   C  G     + +    +D C    H C H EC+N+  S+ CHC  G+T +    
Sbjct: 340  GSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKK 398

Query: 2402 TCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLC 2461
            TC  ++ C+     C   C N + S+ C C RGY L+ +G+TC  +D C  + H C+ LC
Sbjct: 399  TCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC 458

Query: 2462 VNTVGAFTCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTL 2519
            +NT  +F C+C  GF   +  + C   D C      C     C N   SF C+C +G  L
Sbjct: 459  LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFACQCPEGHVL 516

Query: 2520 VSSGHGCEDVNECD-GPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPT 2578
             S G  C  ++ C  G H C+H C +    + C C +G+        C  ++ C      
Sbjct: 517  RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHG 576

Query: 2579 CGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQ 2638
            C    C N+   + C C  GF   +    C+  D C      C + C N    ++C C +
Sbjct: 577  CEHI-CVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSE 635

Query: 2639 GYFRAGQG 2646
            G+  A  G
Sbjct: 636  GFVLAEDG 643



 Score =  182 bits (463), Expect = 3e-45
 Identities = 131/419 (31%), Positives = 173/419 (41%), Gaps = 46/419 (10%)

Query: 463 CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
           C+NIPG+Y CRC  G+     +  C   D C +    C    CVN  GSF C C +G+ L
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311

Query: 523 SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGIC 582
           + DGK CV  + CA+        C+N DGS+ C C  GF L P    C  ID C +    
Sbjct: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371

Query: 583 VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSEC 642
               C NT+ S+ C CL G  +  D + C     R   Y A+ K  C            C
Sbjct: 372 CQHECVNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNKPGCEHECVNMEESYYC 426

Query: 643 -C------------------CANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD- 682
            C                  CA  DHG    C+         F   CS G  I  D +  
Sbjct: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFVCQCSEGFLINEDLKTC 482

Query: 683 --INECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWC 740
             ++ C L    C    C N+  S+ C C  G+   + GK C  +D CAL    C++  C
Sbjct: 483 SRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-C 540

Query: 741 QNSPGSYSCSCPPGFHFWQDTEIC--KDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD 798
            +S  S+ C C  G+   +D + C  KDV + +   C   +C N   SYTC+C  G RL 
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCECLEGFRLA 599

Query: 799 PSGTFCLDSTKGTCWLKIQESRCE---VNLQGASLRSECC-ATLGAAWGSPCERCEIDP 853
             G  C    K  C  K     CE   VN  G S   +C    + A  G  C++C   P
Sbjct: 600 EDGKRC--RRKDVC--KSTHHGCEHICVN-NGNSYICKCSEGFVLAEDGRRCKKCTEGP 653



 Score =  181 bits (458), Expect = 1e-44
 Identities = 134/465 (28%), Positives = 196/465 (42%), Gaps = 65/465 (13%)

Query: 1767 CGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGD------ 1820
            C + E  C     CINIPGSY C+C +GY L+       +  CR I ++C+  D      
Sbjct: 242  CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSD-----QTTCR-IQDLCAMEDHNCEQL 293

Query: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVT 1879
            C++  GS++C C+ G+  + D   C+ +D C  +  G    C N  GSY C C  GF + 
Sbjct: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 1880 HNGD-CVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG 1938
             +   C   D C +     C+   C+NT  S+ C C  GF L  D K C   N C     
Sbjct: 354  PDKKTCTKIDYCASS-NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKP 411

Query: 1939 TCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSPGSFQCLC 1996
             C    C N+E S+ C C  G+ +  +   C  +D C+++ + C    C N+  SF C C
Sbjct: 412  GC-EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQC 469

Query: 1997 PPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELC 2056
              GF+++++   C  +R  +C                                   CE  
Sbjct: 470  SEGFLINEDLKTC--SRVDYCLLSDHG-----------------------------CEYS 498

Query: 2057 PQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYS 2116
                  +F   CP GH  +     +   ++ CA     C +  CV+++ SF C+C  GY 
Sbjct: 499  CVNMDRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYI 556

Query: 2117 LDFTGINCVDTDEC-SVGHPCGQGTCTNVIGGFECACADGF---EPGLMMTCEDIDECSL 2172
            L   G  C   D C ++ H C +  C N    + C C +GF   E G    C   D C  
Sbjct: 557  LREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDG--KRCRRKDVCKS 613

Query: 2173 NPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
                C   C N   SY+C C  G+ L EDG  C+   +C +G  D
Sbjct: 614  THHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGPID 655



 Score =  179 bits (453), Expect = 4e-44
 Identities = 129/445 (28%), Positives = 181/445 (40%), Gaps = 50/445 (11%)

Query: 1861 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
            C NI GSY C C  G+++  +       +   +    C    C+N  GSF C C  G+ L
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGSFVCQCYSGYAL 311

Query: 1921 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPN 1978
              DGK CV  + C S    C    C N +GS+ C C  GF +  D   C  ID C+   +
Sbjct: 312  AEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370

Query: 1979 LCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTR 2038
             C    C N+  S+ C C  GF L+ +   C                          +  
Sbjct: 371  GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC-------------------------RRIN 404

Query: 2039 CCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVP-GPDDSREDVNECAENPGVCTN 2097
             C   +PG      CE        ++   C  G+   P G   SR  V+ CA+    C  
Sbjct: 405  YCALNKPG------CEHECVNMEESYYCRCHRGYTLDPNGKTCSR--VDHCAQQDHGCEQ 456

Query: 2098 GVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGF- 2156
             +C+NT+ SF C+C  G+ ++     C   D C +     + +C N+   F C C +G  
Sbjct: 457  -LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHV 515

Query: 2157 --EPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADG 2214
                G   TC  +D C+L    C   C ++E S++C C  GY LREDG  CR  D C   
Sbjct: 516  LRSDG--KTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI 573

Query: 2215 QQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGS 2274
               C      C N   ++ C C  G R L   G+ C   + C +    C +  CVN   S
Sbjct: 574  DHGCEHI---CVNSDDSYTCECLEGFR-LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNS 628

Query: 2275 FRCDCDEGFQPSPTLTECHDIRQGP 2299
            + C C EGF  +     C    +GP
Sbjct: 629  YICKCSEGFVLAEDGRRCKKCTEGP 653



 Score =  171 bits (434), Expect = 7e-42
 Identities = 122/399 (30%), Positives = 168/399 (42%), Gaps = 47/399 (11%)

Query: 1890 CTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLE 1949
            C+TL      F  C+N  GS+ C C+ G+ L +D   C   + C      C    C N+ 
Sbjct: 242  CSTLEHNCAHF--CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVP 298

Query: 1950 GSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGH 2007
            GSF C C  G+ +  D   C+ +D C+ E + C    C N+ GS+ C C  GF L+ +  
Sbjct: 299  GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKK 357

Query: 2008 RCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQEL 2067
             C                         TK   C S   G      C+        ++   
Sbjct: 358  TC-------------------------TKIDYCASSNHG------CQHECVNTDDSYSCH 386

Query: 2068 CPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDT 2127
            C  G    P     R  +N CA N   C +  CVN + S+ C C  GY+LD  G  C   
Sbjct: 387  CLKGFTLNPDKKTCRR-INYCALNKPGCEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRV 444

Query: 2128 DECSV-GHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECSLNPLLCAFRCHNTE 2185
            D C+   H C Q  C N    F C C++GF     + TC  +D C L+   C + C N +
Sbjct: 445  DHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD 503

Query: 2186 GSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPG 2245
             S+ C CP G+ LR DG  C  +D CA G   C      C +   +F C C  G   L  
Sbjct: 504  RSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE---HSCVSSEDSFVCQCFEGY-ILRE 559

Query: 2246 SGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQ 2284
             G+ C   + C A    C +  CVN+  S+ C+C EGF+
Sbjct: 560  DGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFR 597



 Score =  167 bits (424), Expect = 1e-40
 Identities = 133/475 (28%), Positives = 189/475 (39%), Gaps = 82/475 (17%)

Query: 739  WCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRL 797
            +C N PGSY C C  G+    D   C+  D C +       +C N+ GS+ C+C  G  L
Sbjct: 252  FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311

Query: 798  DPSGTFCLDSTKGTCWLKIQESRCE---VNLQGASLRSECCATLGAAWGSPCERCEIDPA 854
               G  C+       +   +   CE   VN  G+ L               C+       
Sbjct: 312  AEDGKRCV----AVDYCASENHGCEHECVNADGSYL---------------CQ------- 345

Query: 855  CARGFA-RMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
            C  GFA      TC  ++ C S    C +  CVNT  S+ C C +G  L+   + C  + 
Sbjct: 346  CHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRI- 403

Query: 914  LEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECE-ACPDPESLEFASLCPRGLGF 972
                      + C +  PG                  CE  C + E   +   C RG   
Sbjct: 404  ----------NYCALNKPG------------------CEHECVNMEE-SYYCRCHRGYTL 434

Query: 973  ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDEC 1032
                    R     V+ C      C    C NT  SF C C+ GF ++   + C+ +D C
Sbjct: 435  DPNGKTCSR-----VDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC 488

Query: 1033 RISPDLCGQGTCVNTPGSFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTN 1089
             +S   C + +CVN   SF C+C  G+     G    K C  +D CA     C   +C +
Sbjct: 489  LLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDG----KTCAKLDSCALGDHGCE-HSCVS 542

Query: 1090 TDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPD 1149
            ++ S+ CQC  G+ L   G  C   D C   D  C H  CVN   ++ C C  GF+   D
Sbjct: 543  SEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAED 601

Query: 1150 RQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204
             + C   + C+  + GC+  C+N   SY C C +G+ L  DGR C    +C E P
Sbjct: 602  GKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC---KKCTEGP 653



 Score =  157 bits (398), Expect = 1e-37
 Identities = 120/406 (29%), Positives = 171/406 (42%), Gaps = 47/406 (11%)

Query: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFN 1668
            CST    C    C N  G+Y C C   Y+ +N       ++       +N  C+ +L  N
Sbjct: 242  CSTLEHNCAH-FCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHN--CE-QLCVN 296

Query: 1669 VTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEI 1728
            V     C  Y+ G A     + C   ++ DY   C ++  G                   
Sbjct: 297  VPGSFVCQCYS-GYALAEDGKRC---VAVDY---CASENHG------------------- 330

Query: 1729 PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYR 1788
               C +  C+N  GS+ C+C  GF  N     C  +D C S    CQ   +C+N   SY 
Sbjct: 331  ---CEHE-CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH--ECVNTDDSYS 384

Query: 1789 CKCTRGYKLSPG-GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
            C C +G+ L+P    C   N C      C H +C++ E SY C CHRG+    +   C  
Sbjct: 385  CHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR 443

Query: 1848 IDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVTHN-GDCVDFDECTTLVGQVCRFGHCLN 1905
            +D C +Q  G    C N   S+ C C  GF++  +   C   D C  L    C +  C+N
Sbjct: 444  VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYS-CVN 501

Query: 1906 TAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD 1965
               SF C C +G  L +DGK C   + C +L       +C + E SF C C  G+ ++ D
Sbjct: 502  MDRSFACQCPEGHVLRSDGKTCAKLDSC-ALGDHGCEHSCVSSEDSFVCQCFEGYILRED 560

Query: 1966 --HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC 2009
               C   D C    + C    C NS  S+ C C  GF L+++G RC
Sbjct: 561  GKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605



 Score =  150 bits (378), Expect = 2e-35
 Identities = 115/436 (26%), Positives = 163/436 (37%), Gaps = 57/436 (13%)

Query: 1378 CLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELD 1437
            C+N PG Y C C+ G+    D   C+  D CA  +      C N+PG F C C  GY L 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312

Query: 1438 RGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETH 1497
              G  C  ++ CA   +     C+N  GSYLC C + F LNP    C  T+   C    H
Sbjct: 313  EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYCASSNH 370

Query: 1498 D------RGDSGISCSAEIG--VGVTRASC----CCSLGRAWGNPCELCPMANTTEYRTL 1545
                     D   SC    G  +   + +C     C+L +     CE   +     Y   
Sbjct: 371  GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKP---GCEHECVNMEESYYCR 427

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICED 1605
            C  G    PN  T     +D C +    C+   C+NT  SF C+C  G+ ++E  + C  
Sbjct: 428  CHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484

Query: 1606 IDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNEL 1665
            +D C      C   +C N   ++ C CP  ++  + G  C  +       H    C++  
Sbjct: 485  VDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH---GCEHSC 540

Query: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDEC 1725
              +    +C C    G       + C                               D C
Sbjct: 541  VSSEDSFVCQCFE--GYILREDGKTCRRK----------------------------DVC 570

Query: 1726 GEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785
              I   C + IC+N   S+ CEC  GF        C   D C S    C+    C+N   
Sbjct: 571  QAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICVNNGN 627

Query: 1786 SYRCKCTRGYKLSPGG 1801
            SY CKC+ G+ L+  G
Sbjct: 628  SYICKCSEGFVLAEDG 643



 Score =  147 bits (371), Expect = 1e-34
 Identities = 136/471 (28%), Positives = 182/471 (38%), Gaps = 64/471 (13%)

Query: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586
           K C  H  C+T        C+N  GS+ C CK G++L      C   D C          
Sbjct: 235 KLCTAHM-CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293

Query: 587 CTNTEGSFRCQCLGGLAVGTDGRVCV-------DTH-VRSTCYGA-------IEKGSCAR 631
           C N  GSF CQC  G A+  DG+ CV       + H     C  A         +G    
Sbjct: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353

Query: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECAL 688
           P   T TK +  CA+ +HG    CQ         +   C  G  +  D    R IN CAL
Sbjct: 354 PDKKTCTKID-YCASSNHG----CQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCAL 408

Query: 689 DPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYS 748
           +   C +  C N+  SY C C+ GY    +GK C+ VD CA     C+   C N+  S+ 
Sbjct: 409 NKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFV 466

Query: 749 CSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFC--L 805
           C C  GF   +D + C  VD C LS       C N+  S+ C+C  G  L   G  C  L
Sbjct: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKL 526

Query: 806 DSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGF-ARMTG 864
           DS        + +  CE +   +     C                    C  G+  R  G
Sbjct: 527 DS------CALGDHGCEHSCVSSEDSFVC-------------------QCFEGYILREDG 561

Query: 865 VTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDED 924
            TC   + C++    C +  CVN+  S+ CEC EG  L   G+ C   R + C  +    
Sbjct: 562 KTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC--KSTHH 616

Query: 925 ECGVTLPGKYRMDVCCCSIGAVW---GVECEACPD-PESLEFASLCPRGLG 971
            C           +C CS G V    G  C+ C + P  L F     + LG
Sbjct: 617 GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLG 667



 Score =  146 bits (368), Expect = 3e-34
 Identities = 132/499 (26%), Positives = 191/499 (38%), Gaps = 102/499 (20%)

Query: 587  CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
            C N  GS+ C+C  G  + +D   C                           + +  CA 
Sbjct: 253  CINIPGSYVCRCKQGYILNSDQTTC---------------------------RIQDLCAM 285

Query: 647  PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD---INECALDPEVCANGVCENLRG 703
             DH   + C   P      F   C SG  +  DG+    ++ CA +   C +  C N  G
Sbjct: 286  EDHNCEQLCVNVPGS----FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADG 340

Query: 704  SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763
            SY C C+ G+      K CT +D CA ++  C +  C N+  SYSC C  GF    D + 
Sbjct: 341  SYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKT 399

Query: 764  CKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822
            C+ ++ C L+ P     C N+  SY C+C  G  LDP+G  C  S    C    Q+  CE
Sbjct: 400  CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC--SRVDHC--AQQDHGCE 455

Query: 823  VNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGV-TCDDVNECESFPGVCP 881
                      + C  L       C+       C+ GF     + TC  V+ C      C 
Sbjct: 456  ----------QLC--LNTEDSFVCQ-------CSEGFLINEDLKTCSRVDYCLLSDHGCE 496

Query: 882  NGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCC 941
               CVN   SF C+CPEG +L + G+ C   +L+ C L   +  C  +        VC C
Sbjct: 497  YS-CVNMDRSFACQCPEGHVLRSDGKTC--AKLDSCAL--GDHGCEHSCVSSEDSFVCQC 551

Query: 942  SIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT 1001
              G +   + + C                              KDV  C+     C H  
Sbjct: 552  FEGYILREDGKTCR----------------------------RKDV--CQAIDHGCEH-I 580

Query: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYES 1061
            C N+  S+ C C  GF L    + C   D C+ +   C +  CVN   S+ C+C      
Sbjct: 581  CVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC----SE 635

Query: 1062 GFMLMKNCMDVDECARDPL 1080
            GF+L ++     +C   P+
Sbjct: 636  GFVLAEDGRRCKKCTEGPI 654



 Score =  137 bits (344), Expect = 2e-31
 Identities = 123/470 (26%), Positives = 170/470 (36%), Gaps = 91/470 (19%)

Query: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC--ED 289
           C++G+I N     C+  D C      C+   CVN+ GSF C+C  G+ L++    C   D
Sbjct: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322

Query: 290 YRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP-----PRGSNEFQQ 344
           Y    C S   G  C  +         C C  G  +A  P  + C         ++  Q 
Sbjct: 323 Y----CASENHG--CEHECVNADGSYLCQCHEG--FALNPDKKTCTKIDYCASSNHGCQH 374

Query: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
            C         H      L GF             LNP     R           I    
Sbjct: 375 ECVNTDDSYSCH-----CLKGF------------TLNPDKKTCR----------RINYCA 407

Query: 405 LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGD- 462
           LN+    C H         C+    SY C C+ GYT D  G+ C  VD C      HG  
Sbjct: 408 LNK--PGCEH--------ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGCE 455

Query: 463 --CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGF 520
             C+N   ++ C+C  GF      + C  VD C++S   C    CVN + SF C C  G 
Sbjct: 456 QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGH 514

Query: 521 ELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPG 580
            L  DGK C   + CA         C++ + SF C C  G++L   G  C   D CQ   
Sbjct: 515 VLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAID 574

Query: 581 ICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKS 640
                 C N++ S+ C+CL G  +  DG+ C                           + 
Sbjct: 575 HGCEHICVNSDDSYTCECLEGFRLAEDGKRC---------------------------RR 607

Query: 641 ECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDP 690
           +  C +  HG    C+     +   +   CS G  +  DGR   +C   P
Sbjct: 608 KDVCKSTHHG----CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653



 Score =  113 bits (283), Expect = 2e-24
 Identities = 105/409 (25%), Positives = 154/409 (37%), Gaps = 63/409 (15%)

Query: 223 ELCPAQPHPCRR-------GFIPNIHTG--------ACQDVDECQAVPGLCQGGSCVNMV 267
           +LC  + H C +        F+   ++G         C  VD C +    C+   CVN  
Sbjct: 281 DLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339

Query: 268 GSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAA 327
           GS+ C+C  G  L+     C   +   C S   G  C  +         C C +G  +  
Sbjct: 340 GSYLCQCHEGFALNPDKKTCT--KIDYCASSNHG--CQHECVNTDDSYSCHCLKG--FTL 393

Query: 328 GPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDA 387
            P  + C  R  N     CA         PG     +    +          L+P+G   
Sbjct: 394 NPDKKTC--RRIN----YCAL------NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441

Query: 388 RGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGY--TQDVRG 445
                                +D C    + C    CL T  S+ C+C+ G+   +D++ 
Sbjct: 442 -------------------SRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFLINEDLK- 480

Query: 446 ECIDVDECTSSPCHHG---DCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHL 502
            C  VD C  S   HG    CVN+  ++ C+C  G       + C  +D C +    C  
Sbjct: 481 TCSRVDYCLLS--DHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE- 537

Query: 503 GRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL 562
             CV++E SF C C  G+ L  DGK C   + C         +C+N D S++C C  GF 
Sbjct: 538 HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFR 597

Query: 563 LAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
           LA  G  C   D C++        C N   S+ C+C  G  +  DGR C
Sbjct: 598 LAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 61/211 (28%), Positives = 74/211 (35%), Gaps = 46/211 (21%)

Query: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGT----- 144
           C EGF   P+  TC   T    C  S   GC   C+N  T    SC C KG+T       
Sbjct: 346 CHEGFALNPDKKTC---TKIDYCA-SSNHGCQHECVN--TDDSYSCHCLKGFTLNPDKKT 399

Query: 145 -------VCGQPICDRGCHNGGRCIGPNRCACVYGF-MGPQCERDYRTGPCFGQVGPEGC 196
                     +P C+  C N         C C  G+ + P  +   R   C  Q    GC
Sbjct: 400 CRRINYCALNKPGCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGC 454

Query: 197 QHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPG 256
           +           LC  T        C+        C  GF+ N     C  VD C     
Sbjct: 455 EQ----------LCLNTED---SFVCQ--------CSEGFLINEDLKTCSRVDYCLLSDH 493

Query: 257 LCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287
            C+  SCVNM  SF C+CP GH L      C
Sbjct: 494 GCEY-SCVNMDRSFACQCPEGHVLRSDGKTC 523



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 66/265 (24%), Positives = 92/265 (34%), Gaps = 47/265 (17%)

Query: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145
           C +GF   P+  TC        C +++  GC   C+N        C C +GYT    G  
Sbjct: 387 CLKGFTLNPDKKTCRRINY---CALNK-PGCEHECVNME--ESYYCRCHRGYTLDPNGKT 440

Query: 146 CGQ-PIC---DRGCHNGGRCIGPNR---CACVYGFM-GPQCERDYRTGPCFGQVGPEGCQ 197
           C +   C   D GC     C+       C C  GF+     +   R   C   +   GC+
Sbjct: 441 CSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL--LSDHGCE 496

Query: 198 HQLTGLVCTKALCCAT--VGRAWGLPC---ELCPAQPHPCRR---------------GFI 237
           +    +  + A  C    V R+ G  C   + C    H C                 G+I
Sbjct: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556

Query: 238 PNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFS 297
                  C+  D CQA+   C+   CVN   S+ C C  G RL++    C   R   C S
Sbjct: 557 LREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCR--RKDVCKS 613

Query: 298 VLFGGRCAGDLAGHYTRRQCCCDRG 322
              G  C      +     C C  G
Sbjct: 614 THHG--CEHICVNNGNSYICKCSEG 636



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 56/219 (25%), Positives = 81/219 (36%), Gaps = 50/219 (22%)

Query: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145
           C EGF    +L TC+       C +S   GC  SC+N    R  +C C +G+     G  
Sbjct: 469 CSEGFLINEDLKTCSR---VDYCLLS-DHGCEYSCVNMD--RSFACQCPEGHVLRSDGKT 522

Query: 146 CGQ----PICDRGCHNGGRCIGPNR---CACVYGFM----GPQCERDYRTGPCFGQVGPE 194
           C +     + D GC +   C+       C C  G++    G  C R      C  Q    
Sbjct: 523 CAKLDSCALGDHGCEHS--CVSSEDSFVCQCFEGYILREDGKTCRRK---DVC--QAIDH 575

Query: 195 GCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAV 254
           GC+H     +C  +    T        CE        C  GF        C+  D C++ 
Sbjct: 576 GCEH-----ICVNSDDSYT--------CE--------CLEGFRLAEDGKRCRRKDVCKST 614

Query: 255 PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAG 293
              C+   CVN   S+ C+C  G  L++    C+    G
Sbjct: 615 HHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  288 bits (736), Expect = 7e-77
 Identities = 187/513 (36%), Positives = 238/513 (46%), Gaps = 74/513 (14%)

Query: 1028 DIDECRISPDLCGQGTCVNTPGSFECECFPGY----ESGFMLMKNCMDVDECARDPLL-- 1081
            D DEC + P    Q  C+NT GS+ C CFPG+    +      +      E  ++P L  
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 1082 -------------------CRGG-----TCTNTDGSYKCQCPPGHELTAKGTACEDIDEC 1117
                               C+        C+   GS  C C PG+ + A G +CED DEC
Sbjct: 664  EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDEC 723

Query: 1118 SLSDGLCPHGQ-CVNVIGAFQCSCHA-----GFQSTPDRQGCVDINECRVQNGGCD--VH 1169
             +    C   Q CVN +G+F C  H      G+     R+ CVDINEC      C    H
Sbjct: 724  LMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRGEH 782

Query: 1170 CINTEGSYRC----SCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPGGHRCL-- 1222
            C+NT GS+ C    +C  GY+L  DG  C DVDEC      C  G  C N  G   C   
Sbjct: 783  CVNTLGSFHCYKALTCEPGYALK-DGE-CEDVDECAMGTHTCQPGFLCQNTKGSFYCQAR 840

Query: 1223 --CYDGFMATPDMRTCVDVDECDLNPHICLHG-DCENTKGSFVCH-----CQLGYMVRKG 1274
              C DGF+  P+   CVD++EC      C  G  C NT GS+ C      C  GY     
Sbjct: 841  QRCMDGFLQDPE-GNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDD 899

Query: 1275 ATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGF--ECHDLDECVSQEHRC 1332
             T C DV+ECE G H C     C N+PGS+ C C  G+  D F   C D++EC +   R 
Sbjct: 900  GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRL 959

Query: 1333 SPRGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECE 1390
              +  C N  GSYRC+C  GF  A DG  CED +EC      C   +C N  G Y+C C 
Sbjct: 960  C-QHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC--EAQRCSQ-ECANIYGSYQCYCR 1015

Query: 1391 MGFDPTEDHRACQDVDECAQGN--LCAFGSCENLPGMFRCIC-NGGYELDRGGGNCTDIN 1447
             G+   ED   C D+DECAQG   LC F  C N+PG ++C C   GY +   G +C D++
Sbjct: 1016 QGYQLAEDGHTCTDIDECAQGAGILCTF-RCLNVPGSYQCACPEQGYTMTANGRSCKDVD 1074

Query: 1448 ECA-DPVNCING-VCINTPGSYLC---SCPQDF 1475
            ECA    NC     C N  GS+ C    CP ++
Sbjct: 1075 ECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1107



 Score =  277 bits (708), Expect = 1e-73
 Identities = 224/723 (30%), Positives = 295/723 (40%), Gaps = 136/723 (18%)

Query: 979  SGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC-------ACAGGF--ALDAQERNCTDI 1029
            +G+ +  D +EC   P   T      T     C       +C  G   A + +     D 
Sbjct: 448  AGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDN 507

Query: 1030 DECRISP-----DLCGQGTCVNTPGSFECECFP--GYESGFMLMKNCMDVDECARDPLLC 1082
            D C IS      D CG G  V   G   CE  P  GY    +++ +C + +E    P + 
Sbjct: 508  DSCGISLYKQCCDCCGLGLRVRAEGQ-SCESNPNLGYPCNHVML-SCCEGEEPLIVPEVR 565

Query: 1083 RGGTCTNTDGSYKCQCPPGHELTAKGTACE--------DIDECSLSDG-LCPHGQCVNVI 1133
            R                 G E  + GT  E        D DEC L  G LC H  C+N +
Sbjct: 566  RPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQH-LCINTV 624

Query: 1134 GAFQCSCHAGFQSTPDRQGC---------------------------------VDINECR 1160
            G++ C+C  GF    D + C                                    N C+
Sbjct: 625  GSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCK 684

Query: 1161 VQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPG-- 1217
              NG C   C    GS  CSC  GY++M DG +C D DEC      C +   C N  G  
Sbjct: 685  -DNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSF 743

Query: 1218 ---GHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVCH----CQLGY 1269
                H  LC DG++     R CVD++EC  + H C  G+ C NT GSF C+    C+ GY
Sbjct: 744  YCVNHTVLCADGYILNAH-RKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 802

Query: 1270 MVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC----RCLPGWVGD-GFECHDLDE 1324
             ++ G   C DVDEC +G H C     C N  GSF C    RC+ G++ D    C D++E
Sbjct: 803  ALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINE 860

Query: 1325 CVSQEHRCSPRGDCLNVPGSYRC-----TCRQGF--AGDGFFCEDRDECAENVDLCDNGQ 1377
            C S    C P   C+N  GSY C      C +G+  + DG  C D +EC   V  C  GQ
Sbjct: 861  CTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQ 920

Query: 1378 -CLNAPGGYRCECEMGFDPTEDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGY 1434
             C N PG YRC+C+ GF      R C DV+EC  + G LC   +CEN  G +RC C  G+
Sbjct: 921  VCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGF 979

Query: 1435 ELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFL 1494
             L   G  C D+NEC +   C +  C N  GSY C C Q ++L   G  C D        
Sbjct: 980  LLAADGKRCEDVNEC-EAQRC-SQECANIYGSYQCYCRQGYQLAEDGHTCTDID------ 1031

Query: 1495 ETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQP 1554
                       C+   G G+     C ++                  Y+  CP  +G+  
Sbjct: 1032 ----------ECAQ--GAGILCTFRCLNV---------------PGSYQCACP-EQGYTM 1063

Query: 1555 NRITVILEDIDECQELPGLCQGGD-CVNTFGSFQC---ECPPGYHLSEHTR----ICEDI 1606
                   +D+DEC      C   + C N  GSF+C   ECPP Y     T+     C D 
Sbjct: 1064 TANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDF 1123

Query: 1607 DEC 1609
             EC
Sbjct: 1124 LEC 1126



 Score =  261 bits (668), Expect = 5e-69
 Identities = 239/814 (29%), Positives = 328/814 (40%), Gaps = 131/814 (16%)

Query: 2027 SVPKAFNTTKTRCCCSKRPGEGWG---DPCELCPQEGSA-----AFQELCPFGH------ 2072
            S P+         CC+   G+ W    D C   P+ G+        Q  C   +      
Sbjct: 432  SSPEGSTKDLIETCCAA--GQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSC 489

Query: 2073 -----GAVPGPDDSREDVNECA-----ENPGVCTNGVCVNTDGSFRCECP--FGYSLDFT 2120
                 GA  G     ED + C      +    C  G+ V  +G   CE     GY  +  
Sbjct: 490  MAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQ-SCESNPNLGYPCNHV 548

Query: 2121 GINCVDTDEC----SVGHPCGQGTCTNVIGGFECACADGFEPGL------MMTCEDIDEC 2170
             ++C + +E      V  P         +   E A  +    G        +  +D DEC
Sbjct: 549  MLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDEC 608

Query: 2171 SLNP-LLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
             L P  LC   C NT GSY C C  G++L++DG  CR        +     +    K+  
Sbjct: 609  LLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAP---QEPALKSEF 665

Query: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
               A    P   P P +   C D+  C           C    GS  C C  G+      
Sbjct: 666  SQVASNTIPLPLPQPNT---CKDNGPCKQV--------CSTVGGSAICSCFPGYAIMADG 714

Query: 2290 TECHDIRQGPCFAEV----LQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTS 2345
              C D  Q  C         +  C +   S   V     C  G                +
Sbjct: 715  VSCED--QDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYI-------------LN 759

Query: 2346 AYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGE-CINSLGSFRCH----CQAGYTPDATA 2400
            A+RK             D++EC    H C+ GE C+N+LGSF C+    C+ GY      
Sbjct: 760  AHRKCV-----------DINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYA--LKD 806

Query: 2401 TTCLDMDECSQVPKPCT--FLCKNTKGSFLCS----CPRGYLLEEDGRTCKDLDECTSRQ 2454
              C D+DEC+     C   FLC+NTKGSF C     C  G+L + +G  C D++ECTS  
Sbjct: 807  GECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDINECTSLS 865

Query: 2455 HNCQ--FLCVNTVGAFTCR-----CPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHNT 2505
              C+  F C+NTVG++TC+     C  G+  +     C D +EC      CG    CHN 
Sbjct: 866  EPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNL 925

Query: 2506 PGSFRCECHQGFTLVSSGHGCEDVNEC-DGPHR-CQHGCQNQLGGYRCSCPQGFTQHSQW 2563
            PGS+RC+C  GF   + G GC DVNEC   P R CQH C+N LG YRCSC  GF   +  
Sbjct: 926  PGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADG 985

Query: 2564 AQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGP-CS 2622
             +C D NEC      C S  C N  G ++C C  G+   +    C ++DECA   G  C+
Sbjct: 986  KRCEDVNECEAQ--RC-SQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCT 1042

Query: 2623 YSCANTPGGFLCGCP-QGYFRAGQGH-CVSGLGFSPGPQDTPDKE---ELLSSEAC--YE 2675
            + C N PG + C CP QGY     G  C      + G  +  + E    +  S  C  +E
Sbjct: 1043 FRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFE 1102

Query: 2676 CKINGLS-PRDRPRRSAHRDHQVNLATLDSEALLT---LGLNLSHLGRAERILELRPALE 2731
            C  N +   + +  R+   D    L   +S A +T   L      L  A  I  + PA  
Sbjct: 1103 CPPNYVQVSKTKCERTTCHDF---LECQNSPARITHYQLNFQTGLLVPAH-IFRIGPAPA 1158

Query: 2732 GLEGRIRYVIVRGNEQGFF---RMHHLRGVSSLQ 2762
                 I   I++GNE+G+F   R++   GV  LQ
Sbjct: 1159 FTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQ 1192



 Score =  261 bits (668), Expect = 5e-69
 Identities = 191/573 (33%), Positives = 259/573 (45%), Gaps = 102/573 (17%)

Query: 766  DVDECLSSP--CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDS---------------- 807
            D DECL  P      +C N  GSY C C PG  L   G  C                   
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 808  -----TKGTCWLKI-QESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFAR 861
                    T  L + Q + C+ N        + C+T+G +  + C       +C  G+A 
Sbjct: 664  EFSQVASNTIPLPLPQPNTCKDN----GPCKQVCSTVGGS--AIC-------SCFPGYAI 710

Query: 862  MT-GVTCDDVNECESFPGVCPNGR-CVNTAGSFRCE-----CPEGLMLDASGRLCVDVRL 914
            M  GV+C+D +EC      C   + CVNT GSF C      C +G +L+A  R CVD+  
Sbjct: 711  MADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAH-RKCVDI-- 767

Query: 915  EPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFAS 974
                     +EC   L    R + C  ++G+    +   C                G+A 
Sbjct: 768  ---------NECVTDLHTCSRGEHCVNTLGSFHCYKALTCEP--------------GYAL 804

Query: 975  RDFLSGRPFYKDVNECKVFPGLCTHG-TCRNTVGSFHCA----CAGGFALDAQERNCTDI 1029
            +D        +DV+EC +    C  G  C+NT GSF+C     C  GF  D  E NC DI
Sbjct: 805  KDGEC-----EDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDP-EGNCVDI 858

Query: 1030 DECRISPDLCGQG-TCVNTPGSFECE-----CFPGYESGFMLMKNCMDVDECARDPLLC- 1082
            +EC    + C  G +C+NT GS+ C+     C  GY +     K C+DV+EC      C 
Sbjct: 859  NECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK-CVDVNECETGVHRCG 917

Query: 1083 RGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDG-LCPHGQCVNVIGAFQCSCH 1141
             G  C N  GSY+C C  G +  A G  C D++EC  S G LC H  C N +G+++CSC 
Sbjct: 918  EGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCA 976

Query: 1142 AGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECE 1201
            +GF    D + C D+NEC  Q   C   C N  GSY+C C QGY L  DG  C D+DEC 
Sbjct: 977  SGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECA 1034

Query: 1202 ENPRVCDQGHCTNMPGGHRCLCYD-GFMATPDMRTCVDVDECDLNPHICLHGD-CENTKG 1259
            +   +     C N+PG ++C C + G+  T + R+C DVDEC L  H C   + C N +G
Sbjct: 1035 QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQG 1094

Query: 1260 SFVC---HCQLGYM----VRKGATGCSDVDECE 1285
            SF C    C   Y+     +   T C D  EC+
Sbjct: 1095 SFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ 1127



 Score =  254 bits (648), Expect = 1e-66
 Identities = 207/612 (33%), Positives = 258/612 (42%), Gaps = 120/612 (19%)

Query: 1969 DIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
            D DEC   P       C N+ GS+ C C PGF L D+G  C                   
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTC------------------- 644

Query: 2029 PKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNEC 2088
                           RP EG   P    PQE  A   E        +P P       N C
Sbjct: 645  ---------------RP-EGH-PPQPEAPQE-PALKSEFSQVASNTIPLP---LPQPNTC 683

Query: 2089 AENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVG-HPCGQGT-CTNVIG 2146
             +N G C   VC    GS  C C  GY++   G++C D DEC +G H C +   C N +G
Sbjct: 684  KDN-GPCKQ-VCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLG 741

Query: 2147 GFECA-----CADGFEPGLMMTCEDIDECSLNPLLCAF--RCHNTEGSYLC----TCPAG 2195
             F C      CADG+       C DI+EC  +   C+    C NT GS+ C    TC  G
Sbjct: 742  SFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPG 801

Query: 2196 YTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV----CPPGMRPLPGSGEGCT 2251
            Y L++    C DVDECA G   C   G  C+N  G+F C     C  G    P     C 
Sbjct: 802  YALKD--GECEDVDECAMGTHTCQP-GFLCQNTKGSFYCQARQRCMDGFLQDPEGN--CV 856

Query: 2252 DDNECHAQPDLCVNG-RCVNTAGSFRCD-----CDEGFQPSPTLTECHDIRQGPCFAEVL 2305
            D NEC +  + C  G  C+NT GS+ C      C  G+  S   T+C D+          
Sbjct: 857  DINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVN--------- 907

Query: 2306 QTMCRSLSSSSEAVTRAECCCGGGR-GWGPRCELCPLPGTSAYRKLCPHGSGYTAEGR-- 2362
                             EC  G  R G G  C    LPG+  YR  C  G    A GR  
Sbjct: 908  -----------------ECETGVHRCGEGQVCH--NLPGS--YRCDCKAGFQRDAFGRGC 946

Query: 2363 -DVDEC-RMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLC 2420
             DV+EC      LC H  C N+LGS+RC C +G+   A    C D++EC    + C+  C
Sbjct: 947  IDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQEC 1003

Query: 2421 KNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHN-CQFLCVNTVGAFTCRCPP-GFTQ 2478
             N  GS+ C C +GY L EDG TC D+DEC       C F C+N  G++ C CP  G+T 
Sbjct: 1004 ANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTM 1063

Query: 2479 --HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRC---ECHQGFTLVSSGH----GCEDV 2529
              + ++C D DEC+     C     CHN  GSFRC   EC   +  VS        C D 
Sbjct: 1064 TANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDF 1123

Query: 2530 NEC-DGPHRCQH 2540
             EC + P R  H
Sbjct: 1124 LECQNSPARITH 1135



 Score =  253 bits (646), Expect = 2e-66
 Identities = 194/568 (34%), Positives = 246/568 (43%), Gaps = 83/568 (14%)

Query: 1762 EDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDC 1821
            +D DEC        Q+  CIN  GSY C C  G+ L   G       CR        G  
Sbjct: 603  DDQDECLLLPGELCQHL-CINTVGSYHCACFPGFSLQDDG-----RTCRP------EGHP 650

Query: 1822 MDTEGSYMCLCHRGFQASADQTLCMDIDE---C-DRQPCGNGTCKNIIGSYNCLCFPGFV 1877
               E          F   A  T+ + + +   C D  PC    C  + GS  C CFPG+ 
Sbjct: 651  PQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGYA 709

Query: 1878 VTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHC-----LCQDGFELTADGKNCVDTN 1931
            +  +G  C D DEC        R   C+NT GSF+C     LC DG+ L A  K CVD N
Sbjct: 710  IMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDIN 768

Query: 1932 ECLSLAGTCLPGT-CQNLEGSFRCI----CPPGFQVQSDHCIDIDECSEEPNLCLFG-TC 1985
            EC++   TC  G  C N  GSF C     C PG+ ++   C D+DEC+   + C  G  C
Sbjct: 769  ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLC 828

Query: 1986 TNSPGSFQCL----CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCC 2041
             N+ GSF C     C  GF+    G+ C D  +  C +  E   C    +   T     C
Sbjct: 829  QNTKGSFYCQARQRCMDGFLQDPEGN-CVDINE--CTSLSEP--CRPGFSCINTVGSYTC 883

Query: 2042 SKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNECAENPGVCTNG- 2098
             + P                     +C  G+ A    DD  +  DVNEC      C  G 
Sbjct: 884  QRNP--------------------LICARGYHA---SDDGTKCVDVNECETGVHRCGEGQ 920

Query: 2099 VCVNTDGSFRCECPFGYSLDFTGINCVDTDEC--SVGHPCGQGTCTNVIGGFECACADGF 2156
            VC N  GS+RC+C  G+  D  G  C+D +EC  S G  C Q TC N +G + C+CA GF
Sbjct: 921  VCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC-QHTCENTLGSYRCSCASGF 979

Query: 2157 EPGLM-MTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQ 2215
                    CED++EC      C+  C N  GSY C C  GY L EDG  C D+DECA G 
Sbjct: 980  LLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGA 1037

Query: 2216 QD-CHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGR-CVNTAG 2273
               C  R   C N+ G++ C CP     +  +G  C D +EC      C     C N  G
Sbjct: 1038 GILCTFR---CLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQG 1094

Query: 2274 SFRC---DCDEGF-QPSPT---LTECHD 2294
            SFRC   +C   + Q S T    T CHD
Sbjct: 1095 SFRCLRFECPPNYVQVSKTKCERTTCHD 1122



 Score =  232 bits (591), Expect = 4e-60
 Identities = 188/623 (30%), Positives = 245/623 (39%), Gaps = 118/623 (18%)

Query: 1188 MPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC----------- 1236
            +P+     D DEC   P    Q  C N  G + C C+ GF    D RTC           
Sbjct: 596  LPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEA 655

Query: 1237 ------------VDVDECDL---NPHICLHGD-----CENTKGSFVCHCQLGYMVRKGAT 1276
                        V  +   L    P+ C         C    GS +C C  GY +     
Sbjct: 656  PQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGV 715

Query: 1277 GCSDVDECEVGGHNCDSHASCLNIPGSFSC-----RCLPGWVGDGF-ECHDLDECVSQEH 1330
             C D DEC +G H+C     C+N  GSF C      C  G++ +   +C D++ECV+  H
Sbjct: 716  SCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLH 775

Query: 1331 RCSPRGDCLNVPGSYRC----TCRQGFAGDGFFCEDRDECAENVDLCDNG-QCLNAPGGY 1385
             CS    C+N  GS+ C    TC  G+A     CED DECA     C  G  C N  G +
Sbjct: 776  TCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSF 835

Query: 1386 RCE----CEMGF--DPTEDHRACQDVDECAQ-GNLCAFG-SCENLPGMFRC-----ICNG 1432
             C+    C  GF  DP  +   C D++EC      C  G SC N  G + C     IC  
Sbjct: 836  YCQARQRCMDGFLQDPEGN---CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICAR 892

Query: 1433 GYELDRGGGNCTDINECADPVN-CING-VCINTPGSYLCSCPQDFELNPSGVGCVDTRAG 1490
            GY     G  C D+NEC   V+ C  G VC N PGSY C C   F+ +  G GC+D    
Sbjct: 893  GYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVN-- 950

Query: 1491 NCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTT-EYRTLCPGG 1549
                                        C  S GR   + CE     NT   YR  C   
Sbjct: 951  ---------------------------ECWASPGRLCQHTCE-----NTLGSYRCSC--A 976

Query: 1550 EGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDEC 1609
             GF         ED++EC+     C   +C N +GS+QC C  GY L+E    C DIDEC
Sbjct: 977  SGFLLAADGKRCEDVNECEAQR--CSQ-ECANIYGSYQCYCRQGYQLAEDGHTCTDIDEC 1033

Query: 1610 STHSGICGPGTCYNTLGNYTCVCPAE-YLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFN 1668
            +  +GI     C N  G+Y C CP + Y     G +C D+ +  C    +   + E   N
Sbjct: 1034 AQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE--CALGTHNCSEAETCHN 1091

Query: 1669 VTRKMCC----CSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLT----DIHTG--K 1718
            +     C    C  N  Q     CE      +  +  L    +P  +T    +  TG   
Sbjct: 1092 IQGSFRCLRFECPPNYVQVSKTKCER-----TTCHDFLECQNSPARITHYQLNFQTGLLV 1146

Query: 1719 PLDIDECGEIPAICANGICINQI 1741
            P  I   G  PA   + I +N I
Sbjct: 1147 PAHIFRIGPAPAFTGDTIALNII 1169



 Score =  230 bits (586), Expect = 2e-59
 Identities = 224/766 (29%), Positives = 305/766 (39%), Gaps = 140/766 (18%)

Query: 507  NTEGSFQCVCNAGFELSPDGKNCVDHNECATS-TMCVNG---VCLNEDGSFSCLCKPGFL 562
            +T+   +  C AG + + D   C++  E  T   +C       C++     SC+   G L
Sbjct: 437  STKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMA--GVL 494

Query: 563  LAPGGHYC--MDIDECQTPGICVNGHCTNTEGSFRCQCLG-GLAVGTDGRVCVDTHVRST 619
             A  G  C   D D C   GI +   C        C C G GL V  +G+ C        
Sbjct: 495  GAKEGETCGAEDNDSC---GISLYKQC--------CDCCGLGLRVRAEGQSCESNPNLGY 543

Query: 620  CYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC---SSGLGI 676
                +    C    P  V +       P      P ++  A + A  +AL     + L  
Sbjct: 544  PCNHVMLSCCEGEEPLIVPEVR----RPPEPAAAPRRVSEA-EMAGREALSLGTEAELPN 598

Query: 677  TTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDC-------------- 722
            +  G D +EC L P      +C N  GSY C C  G+     G+ C              
Sbjct: 599  SLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQE 658

Query: 723  ----TDVDECALNSL--------LC-DNG----WCQNSPGSYSCSCPPGFHFWQDTEICK 765
                ++  + A N++         C DNG     C    GS  CSC PG+    D   C+
Sbjct: 659  PALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCE 718

Query: 766  DVDECL--SSPCV-SGVCRNLAGSYTC-----KCGPGSRLDPSGTFCLDSTKGTCWLKIQ 817
            D DECL  +  C     C N  GS+ C      C  G  L+ +   C+D           
Sbjct: 719  DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILN-AHRKCVDI---------- 767

Query: 818  ESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFP 877
             + C  +L   S    C  TLG+        C     C  G+A   G  C+DV+EC    
Sbjct: 768  -NECVTDLHTCSRGEHCVNTLGSF------HCYKALTCEPGYALKDG-ECEDVDECAMGT 819

Query: 878  GVC-PNGRCVNTAGSFRCE----CPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPG 932
              C P   C NT GSF C+    C +G + D  G  CVD+           +EC  +L  
Sbjct: 820  HTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDI-----------NEC-TSLSE 866

Query: 933  KYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKV 992
              R    C  I  V    C+  P         +C RG   AS D         DVNEC+ 
Sbjct: 867  PCRPGFSC--INTVGSYTCQRNP--------LICARGY-HASDDGTK----CVDVNECET 911

Query: 993  FPGLCTHG-TCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSF 1051
                C  G  C N  GS+ C C  GF  DA  R C D++EC  SP    Q TC NT GS+
Sbjct: 912  GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSY 971

Query: 1052 ECECFPGYESGFMLM---KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKG 1108
             C C     SGF+L    K C DV+EC           C N  GSY+C C  G++L   G
Sbjct: 972  RCSC----ASGFLLAADGKRCEDVNECEAQRC---SQECANIYGSYQCYCRQGYQLAEDG 1024

Query: 1109 TACEDIDECSLSDGLCPHGQCVNVIGAFQCSC-HAGFQSTPDRQGCVDINECRVQNGGCD 1167
              C DIDEC+   G+    +C+NV G++QC+C   G+  T + + C D++EC +    C 
Sbjct: 1025 HTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCS 1084

Query: 1168 --VHCINTEGSYRC---SCGQGYSLMP----DGRACADVDECEENP 1204
                C N +GS+RC    C   Y  +     +   C D  EC+ +P
Sbjct: 1085 EAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSP 1130



 Score =  226 bits (576), Expect = 2e-58
 Identities = 221/761 (29%), Positives = 299/761 (39%), Gaps = 163/761 (21%)

Query: 1306 CRCLPGWVGDGFECHDLDECVSQEHRC--SPRGDCLNVPGSYRCTCRQGFAGDGFFC--E 1361
            C     W  D  EC ++ E  ++++ C  + R  C++      C      A +G  C  E
Sbjct: 446  CAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAE 505

Query: 1362 DRDECAENV-----DLCDNGQCLNAPG---------GYRCE-----CEMGFDPT------ 1396
            D D C  ++     D C  G  + A G         GY C      C  G +P       
Sbjct: 506  DNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVR 565

Query: 1397 ---EDHRACQDVDEC--AQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECAD 1451
               E   A + V E   A     + G+   LP                     D +EC  
Sbjct: 566  RPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPG---------------DDQDECLL 610

Query: 1452 -PVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEI 1510
             P      +CINT GSY C+C   F L                       D G +C  E 
Sbjct: 611  LPGELCQHLCINTVGSYHCACFPGFSLQ----------------------DDGRTCRPE- 647

Query: 1511 GVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQEL 1570
                             G+P    P     +   L         N I + L   + C++ 
Sbjct: 648  -----------------GHP----PQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKD- 685

Query: 1571 PGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT-CYNTLGNYT 1629
             G C+   C    GS  C C PGY +      CED DEC   +  C     C NTLG++ 
Sbjct: 686  NGPCKQV-CSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFY 744

Query: 1630 CV-----CPAEYLQVNGGNNCMDMRKSVCFRHYNGTC-QNELAFNVTRKMCCCSYNIGQA 1683
            CV     C   Y+ +N    C+D+ + V   H   TC + E   N      C        
Sbjct: 745  CVNHTVLCADGYI-LNAHRKCVDINECVTDLH---TCSRGEHCVNTLGSFHCYKA----- 795

Query: 1684 WNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANG-ICINQIG 1742
                CE                  PG+   +  G+  D+DEC      C  G +C N  G
Sbjct: 796  --LTCE------------------PGYA--LKDGECEDVDECAMGTHTCQPGFLCQNTKG 833

Query: 1743 SFRCE----CPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCK-----CTR 1793
            SF C+    C  GF  +     C D++EC S   PC+    CIN  GSY C+     C R
Sbjct: 834  SFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICAR 892

Query: 1794 GYKLSPGGA-CVGRNECREIPNVCSHGD-CMDTEGSYMCLCHRGFQASADQTLCMDIDEC 1851
            GY  S  G  CV  NEC    + C  G  C +  GSY C C  GFQ  A    C+D++EC
Sbjct: 893  GYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNEC 952

Query: 1852 DRQP---CGNGTCKNIIGSYNCLCFPGFVVTHNGD-CVDFDECTTLVGQVCRFGHCLNTA 1907
               P   C + TC+N +GSY C C  GF++  +G  C D +EC     Q C    C N  
Sbjct: 953  WASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECEA---QRCS-QECANIY 1007

Query: 1908 GSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICP-PGFQVQSD- 1965
            GS+ C C+ G++L  DG  C D +EC   AG      C N+ GS++C CP  G+ + ++ 
Sbjct: 1008 GSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANG 1067

Query: 1966 -HCIDIDECSEEPNLCLFG-TCTNSPGSFQCL---CPPGFV 2001
              C D+DEC+   + C    TC N  GSF+CL   CPP +V
Sbjct: 1068 RSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYV 1108



 Score =  224 bits (572), Expect = 7e-58
 Identities = 183/597 (30%), Positives = 250/597 (41%), Gaps = 127/597 (21%)

Query: 237  IPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGAC 295
            +PN   G   D DEC  +PG LCQ   C+N VGS+HC C  G  L D    C        
Sbjct: 596  LPNSLPG--DDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRP------ 646

Query: 296  FSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP-PRGSNEFQQLCAQRLPLLP 354
                          GH                 P PE    P   +EF Q+ +  +PL  
Sbjct: 647  -------------EGH----------------PPQPEAPQEPALKSEFSQVASNTIPLPL 677

Query: 355  GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRH 414
              P                  GP +          I S  PG + +      +  D C  
Sbjct: 678  PQPNTCKDN------------GPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLM 725

Query: 415  FTNLCLNGR-CLPTPSSYRCE-----CNVGYTQDVRGECIDVDECTSS--PCHHGD-CVN 465
              + C   + C+ T  S+ C      C  GY  +   +C+D++EC +    C  G+ CVN
Sbjct: 726  GAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVN 785

Query: 466  IPGTYHC----RCYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQCV----C 516
              G++HC     C PG+        C DVDEC +    C  G  C NT+GSF C     C
Sbjct: 786  TLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRC 843

Query: 517  NAGFELSPDGKNCVDHNECAT-STMCVNGV-CLNEDGSFSC-----LCKPGFLLAPGGHY 569
              GF   P+G NCVD NEC + S  C  G  C+N  GS++C     +C  G+  +  G  
Sbjct: 844  MDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK 902

Query: 570  CMDIDECQTPGI--CVNGH-CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEK 626
            C+D++EC+T G+  C  G  C N  GS+RC C  G      GR C+D +           
Sbjct: 903  CVDVNECET-GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE---------- 951

Query: 627  GSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DI 683
                            C A+P    G  CQ         ++  C+SG  +  DG+   D+
Sbjct: 952  ----------------CWASP----GRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDV 991

Query: 684  NECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNS 743
            NEC  + + C+   C N+ GSY+C C  GY+    G  CTD+DECA  + +     C N 
Sbjct: 992  NEC--EAQRCSQE-CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNV 1048

Query: 744  PGSYSCSCP-PGFHFWQDTEICKDVDECL--SSPCVSG-VCRNLAGSYTC---KCGP 793
            PGSY C+CP  G+    +   CKDVDEC   +  C     C N+ GS+ C   +C P
Sbjct: 1049 PGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPP 1105



 Score =  202 bits (515), Expect = 3e-51
 Identities = 183/666 (27%), Positives = 266/666 (39%), Gaps = 110/666 (16%)

Query: 1503 GISCSAE----IGVGVTRASC-CCSLG---RAWGNPCELCPMANTTEYRTLCPGGEGFQP 1554
            G +C AE     G+ + +  C CC LG   RA G  CE  P         +    EG +P
Sbjct: 499  GETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEP 558

Query: 1555 NRITVILEDIDEC---QELPGLCQGGDCVNTFGSFQCECP---PGYHLSEHTRICEDIDE 1608
              +  +    +     + +      G    + G+ + E P   PG          +D DE
Sbjct: 559  LIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGT-EAELPNSLPG----------DDQDE 607

Query: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDM---------RKSVCFRHYNG 1659
            C    G      C NT+G+Y C C   +   + G  C            ++      ++ 
Sbjct: 608  CLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQ 667

Query: 1660 TCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKP 1719
               N +   + +   C         N PC+   + +       C    PG+         
Sbjct: 668  VASNTIPLPLPQPNTCKD-------NGPCKQVCSTVGGSAICSC---FPGYAIMADGVSC 717

Query: 1720 LDIDECGEIPAICANG-ICINQIGSFRCE-----CPAGFNYNSILLACEDVDECGSRESP 1773
             D DEC      C+    C+N +GSF C      C  G+  N+    C D++EC +    
Sbjct: 718  EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHR-KCVDINECVTDLHT 776

Query: 1774 CQQNADCINIPGSYRC----KCTRGYKLSPGGACVGRNECREIPNVCSHGD-CMDTEGSY 1828
            C +   C+N  GS+ C     C  GY L  G  C   +EC    + C  G  C +T+GS+
Sbjct: 777  CSRGEHCVNTLGSFHCYKALTCEPGYALKDG-ECEDVDECAMGTHTCQPGFLCQNTKGSF 835

Query: 1829 MCL----CHRGFQASADQTLCMDIDECDR--QPCGNG-TCKNIIGSYNC-----LCFPGF 1876
             C     C  GF    +   C+DI+EC    +PC  G +C N +GSY C     +C  G+
Sbjct: 836  YCQARQRCMDGFLQDPEGN-CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGY 894

Query: 1877 VVTHNGD-CVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLS 1935
              + +G  CVD +EC T V +      C N  GS+ C C+ GF+  A G+ C+D NEC +
Sbjct: 895  HASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWA 954

Query: 1936 LAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQ 1993
              G     TC+N  GS+RC C  GF + +D   C D++EC  E   C    C N  GS+Q
Sbjct: 955  SPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC--EAQRC-SQECANIYGSYQ 1011

Query: 1994 CLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPC 2053
            C C  G+ L+++GH C D  +                                +G G  C
Sbjct: 1012 CYCRQGYQLAEDGHTCTDIDEC------------------------------AQGAGILC 1041

Query: 2054 ELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNG-VCVNTDGSFRC--- 2109
                     ++Q  CP     +     S +DV+ECA     C+    C N  GSFRC   
Sbjct: 1042 TFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRF 1101

Query: 2110 ECPFGY 2115
            ECP  Y
Sbjct: 1102 ECPPNY 1107



 Score =  200 bits (509), Expect = 1e-50
 Identities = 177/552 (32%), Positives = 232/552 (42%), Gaps = 125/552 (22%)

Query: 410  DICRHFTNLCLNGRCLPTPSSYRCECNVGYT-QD---------------------VRGEC 447
            ++C+H   LC+N     T  SY C C  G++ QD                     ++ E 
Sbjct: 614  ELCQH---LCIN-----TVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEF 665

Query: 448  IDVDECT-------------SSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECI 494
              V   T             + PC    C  + G+  C C+PG+       +C D DEC+
Sbjct: 666  SQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGYAIMADGVSCEDQDECL 724

Query: 495  VSGGLCHLGR-CVNTEGSFQCV-----CNAGFELSPDGKNCVDHNECATST-MCVNGV-C 546
            +    C   + CVNT GSF CV     C  G+ L+   K CVD NEC T    C  G  C
Sbjct: 725  MGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRGEHC 783

Query: 547  LNEDGSFSC----LCKPGFLLAPGGHYCMDIDEC-QTPGICVNGH-CTNTEGSFRCQ--- 597
            +N  GSF C     C+PG+ L  G   C D+DEC      C  G  C NT+GSF CQ   
Sbjct: 784  VNTLGSFHCYKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ 841

Query: 598  -CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQ 656
             C+ G     +G  CVD +  ++       G       G+ T    C  NP         
Sbjct: 842  RCMDGFLQDPEGN-CVDINECTSLSEPCRPGFSCINTVGSYT----CQRNP--------- 887

Query: 657  LCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANG-VCENLRGSYRCVCNLG 712
                        +C+ G   + DG    D+NEC      C  G VC NL GSYRC C  G
Sbjct: 888  -----------LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAG 936

Query: 713  YEAGASGKDCTDVDEC-ALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECL 771
            ++  A G+ C DV+EC A    LC +  C+N+ GSY CSC  GF    D + C+DV+EC 
Sbjct: 937  FQRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECE 995

Query: 772  SSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGAS-L 830
            +  C S  C N+ GSY C C  G +L   G  C D         I E       QGA  L
Sbjct: 996  AQRC-SQECANIYGSYQCYCRQGYQLAEDGHTCTD---------IDEC-----AQGAGIL 1040

Query: 831  RSECCATLGAAWGSPCERCEIDPACARGFA-RMTGVTCDDVNECESFPGVCPNGR-CVNT 888
             +  C  +  ++   C          +G+     G +C DV+EC      C     C N 
Sbjct: 1041 CTFRCLNVPGSYQCACPE--------QGYTMTANGRSCKDVDECALGTHNCSEAETCHNI 1092

Query: 889  AGSFRC---ECP 897
             GSFRC   ECP
Sbjct: 1093 QGSFRCLRFECP 1104



 Score =  158 bits (399), Expect = 8e-38
 Identities = 143/526 (27%), Positives = 207/526 (39%), Gaps = 90/526 (17%)

Query: 1361 EDRDECAENV-DLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ---------------- 1403
            +D+DEC     +LC +  C+N  G Y C C  GF   +D R C+                
Sbjct: 603  DDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPAL 661

Query: 1404 --DVDECA---------QGNLCAFGS-----CENLPGMFRCICNGGYELDRGGGNCTDIN 1447
              +  + A         Q N C         C  + G   C C  GY +   G +C D +
Sbjct: 662  KSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQD 721

Query: 1448 ECADPVNCIN--GVCINTPGSYLC-----SCPQDFELNPSGVGCVDTRAGNCFLETHDRG 1500
            EC    +  +    C+NT GS+ C      C   + LN +   CVD       L T  RG
Sbjct: 722  ECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILN-AHRKCVDINECVTDLHTCSRG 780

Query: 1501 DSGI----------SCSAEIGVGVTRASC----CCSLGRAWGNPCELCPMANTTEY---R 1543
            +  +          + + E G  +    C     C++G     P  LC     + Y   R
Sbjct: 781  EHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQAR 840

Query: 1544 TLCPGGEGFQPNRITVILEDIDECQELPGLCQGG-DCVNTFGSFQCE-----CPPGYHLS 1597
              C  G    P    V   DI+EC  L   C+ G  C+NT GS+ C+     C  GYH S
Sbjct: 841  QRCMDGFLQDPEGNCV---DINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHAS 897

Query: 1598 EHTRICEDIDECSTHSGICGPG-TCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRH 1656
            +    C D++EC T    CG G  C+N  G+Y C C A + +   G  C+D+ +  C+  
Sbjct: 898  DDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE--CWAS 955

Query: 1657 YNGTCQNELAFNVTRKMCCCS------------YNIGQAWNRPCEACPTPISPDYQILCG 1704
                CQ+     +    C C+             ++ +   + C      I   YQ  C 
Sbjct: 956  PGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYC- 1014

Query: 1705 NQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECP-AGFNYNSILLACED 1763
             Q      D HT    DIDEC +   I     C+N  GS++C CP  G+   +   +C+D
Sbjct: 1015 RQGYQLAEDGHT--CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1072

Query: 1764 VDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNEC 1809
            VDEC      C +   C NI GS+RC     ++  P    V + +C
Sbjct: 1073 VDECALGTHNCSEAETCHNIQGSFRC---LRFECPPNYVQVSKTKC 1115



 Score =  155 bits (391), Expect = 7e-37
 Identities = 140/465 (30%), Positives = 187/465 (40%), Gaps = 74/465 (15%)

Query: 151  CDRGCHNGGRCIGPNRCACVYGFM----GPQCERDYRTGPCFGQVGPEGCQHQLTGLVCT 206
            C + C   G   G   C+C  G+     G  CE       C   +G   C          
Sbjct: 689  CKQVCSTVG---GSAICSCFPGYAIMADGVSCEDQ---DECL--MGAHDCSR-------- 732

Query: 207  KALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVN 265
            +  C  T+G  +      C      C  G+I N H   C D++EC      C  G  CVN
Sbjct: 733  RQFCVNTLGSFY------CVNHTVLCADGYILNAHR-KCVDINECVTDLHTCSRGEHCVN 785

Query: 266  MVGSFHC----RCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDR 321
             +GSFHC     C  G+ L D      D  A    +   G  C       Y     C  R
Sbjct: 786  TLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFY-----CQAR 840

Query: 322  GRCWAAGPVPELCPPRGS-NEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARL 380
             RC        L  P G+  +  +  +   P  PG    F  +   GS          + 
Sbjct: 841  QRCMDG----FLQDPEGNCVDINECTSLSEPCRPG----FSCINTVGSY-------TCQR 885

Query: 381  NPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGR-CLPTPSSYRCECNVGY 439
            NP       I + G   S+ GT  ++  ++ C    + C  G+ C   P SYRC+C  G+
Sbjct: 886  NPL------ICARGYHASDDGTKCVD--VNECETGVHRCGEGQVCHNLPGSYRCDCKAGF 937

Query: 440  TQDVRGE-CIDVDECTSSP---CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIV 495
             +D  G  CIDV+EC +SP   C H  C N  G+Y C C  GF      + C DV+EC  
Sbjct: 938  QRDAFGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNEC-- 994

Query: 496  SGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATST-MCVNGVCLNEDGSFS 554
                C    C N  GS+QC C  G++L+ DG  C D +ECA    +     CLN  GS+ 
Sbjct: 995  EAQRCS-QECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQ 1053

Query: 555  CLC-KPGFLLAPGGHYCMDIDECQ--TPGICVNGHCTNTEGSFRC 596
            C C + G+ +   G  C D+DEC   T        C N +GSFRC
Sbjct: 1054 CACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRC 1098



 Score =  153 bits (386), Expect = 3e-36
 Identities = 147/487 (30%), Positives = 196/487 (40%), Gaps = 83/487 (17%)

Query: 211  CATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGS 269
            C+TVG +      +C   P     G+       +C+D DEC      C     CVN +GS
Sbjct: 693  CSTVGGS-----AICSCFP-----GYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGS 742

Query: 270  FHC-----RCPVGHRLSDSSAACEDYRAGACFSVLF----GGRCAGDLAGHYTRRQCCCD 320
            F+C      C  G+ L+ +   C D     C + L     G  C   L   +  +   C+
Sbjct: 743  FYCVNHTVLCADGYILN-AHRKCVDINE--CVTDLHTCSRGEHCVNTLGSFHCYKALTCE 799

Query: 321  RGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARL 380
             G     G   ++            CA       G     PG L   + G        R 
Sbjct: 800  PGYALKDGECEDV----------DECAM------GTHTCQPGFLCQNTKGSFYCQARQRC 843

Query: 381  NPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNG-RCLPTPSSYRCE----- 434
                    G      GN           I+ C   +  C  G  C+ T  SY C+     
Sbjct: 844  MD------GFLQDPEGNC--------VDINECTSLSEPCRPGFSCINTVGSYTCQRNPLI 889

Query: 435  CNVGY-TQDVRGECIDVDECTSSPCHHGD---CVNIPGTYHCRCYPGFQATPTRQACVDV 490
            C  GY   D   +C+DV+EC +     G+   C N+PG+Y C C  GFQ     + C+DV
Sbjct: 890  CARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDV 949

Query: 491  DECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNED 550
            +EC  S G      C NT GS++C C +GF L+ DGK C D NEC       +  C N  
Sbjct: 950  NECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANIY 1007

Query: 551  GSFSCLCKPGFLLAPGGHYCMDIDEC-QTPGICVNGHCTNTEGSFRCQC-LGGLAVGTDG 608
            GS+ C C+ G+ LA  GH C DIDEC Q  GI     C N  GS++C C   G  +  +G
Sbjct: 1008 GSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANG 1067

Query: 609  RVCVD-------THVRS---TCYGAIEKGSCAR----PFPGTVTKSECCCANPDHGFGEP 654
            R C D       TH  S   TC+       C R    P    V+K++ C     H F E 
Sbjct: 1068 RSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTK-CERTTCHDFLE- 1125

Query: 655  CQLCPAK 661
            CQ  PA+
Sbjct: 1126 CQNSPAR 1132



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 79/293 (26%), Positives = 108/293 (36%), Gaps = 88/293 (30%)

Query: 58   NVCGSRFHAY----CCPGWRTFPGR----SQCVVP--------ICRRACGEGFCSQPNLC 101
            N  GS FH Y    C PG+    G      +C +         +C+   G  +C      
Sbjct: 785  NTLGS-FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ-- 841

Query: 102  TCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT-----GTVCGQP---ICDR 153
             C DG L    G         +C++   C   S  C+ G++     G+   Q    IC R
Sbjct: 842  RCMDGFLQDPEG---------NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICAR 892

Query: 154  GCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALC 210
            G H   +G +C+  N C              +R G   GQV    C H L G        
Sbjct: 893  GYHASDDGTKCVDVNECETGV----------HRCGE--GQV----C-HNLPG-------- 927

Query: 211  CATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGS 269
                       C+        C+ GF  +     C DV+EC A PG LCQ  +C N +GS
Sbjct: 928  --------SYRCD--------CKAGFQRDAFGRGCIDVNECWASPGRLCQ-HTCENTLGS 970

Query: 270  FHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG 322
            + C C  G  L+     CED     C +     RC+ + A  Y   QC C +G
Sbjct: 971  YRCSCASGFLLAADGKRCED--VNECEA----QRCSQECANIYGSYQCYCRQG 1017



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 65/244 (26%), Positives = 91/244 (37%), Gaps = 52/244 (21%)

Query: 87   RRACGEGFCSQP-------NLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQK 139
            R+ C +GF   P       N CT       P      G  C ++ +   TC+    +C +
Sbjct: 840  RQRCMDGFLQDPEGNCVDINECTSLSEPCRP------GFSC-INTVGSYTCQRNPLICAR 892

Query: 140  GY----TGTVC--------GQPICDRG--CHNGGRCIGPNRCACVYGFMGPQCERD-YRT 184
            GY     GT C        G   C  G  CHN     G  RC C  GF      R     
Sbjct: 893  GYHASDDGTKCVDVNECETGVHRCGEGQVCHN---LPGSYRCDCKAGFQRDAFGRGCIDV 949

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCAT--VGRAWGLPCE---LCPAQPHP-------- 231
              C+   G   CQH     + +    CA+  +  A G  CE    C AQ           
Sbjct: 950  NECWASPG-RLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYG 1008

Query: 232  -----CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCP-VGHRLSDSSA 285
                 CR+G+        C D+DEC    G+     C+N+ GS+ C CP  G+ ++ +  
Sbjct: 1009 SYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGR 1068

Query: 286  ACED 289
            +C+D
Sbjct: 1069 SCKD 1072



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 59/237 (24%), Positives = 82/237 (34%), Gaps = 36/237 (15%)

Query: 56   GPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVS 115
            G + CG     +  PG      R  C     R A G G C   N C  + G L       
Sbjct: 912  GVHRCGEGQVCHNLPG----SYRCDCKAGFQRDAFGRG-CIDVNECWASPGRL------- 959

Query: 116  RGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMG 175
                C  +C N  T     C C  G+     G+   D       RC     CA +YG   
Sbjct: 960  ----CQHTCEN--TLGSYRCSCASGFLLAADGKRCEDVNECEAQRC--SQECANIYGSYQ 1011

Query: 176  PQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRG 235
              C + Y+               Q  G++CT    C  V  ++   C           +G
Sbjct: 1012 CYCRQGYQLAEDGHTCTDIDECAQGAGILCT--FRCLNVPGSYQCACP---------EQG 1060

Query: 236  FIPNIHTGACQDVDECQAVPGLC-QGGSCVNMVGSFHC---RCPVGHRLSDSSAACE 288
            +    +  +C+DVDEC      C +  +C N+ GSF C    CP  + +  S   CE
Sbjct: 1061 YTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY-VQVSKTKCE 1116


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  262 bits (670), Expect = 3e-69
 Identities = 195/600 (32%), Positives = 262/600 (43%), Gaps = 92/600 (15%)

Query: 979  SGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC-------ACAGGF--ALDAQERNCTDI 1029
            +G+ +  D +EC   P   T      T     C       +C  G   A + +     D 
Sbjct: 448  AGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDN 507

Query: 1030 DECRISP-----DLCGQGTCVNTPGSFECECFP--GYESGFMLMKNCMDVDECARDPLLC 1082
            D C IS      D CG G  V   G   CE  P  GY    +++ +C + +E    P + 
Sbjct: 508  DSCGISLYKQCCDCCGLGLRVRAEGQ-SCESNPNLGYPCNHVML-SCCEGEEPLIVPEVR 565

Query: 1083 RGGTCTNTDGSYKCQCPPGHELTAKGTACE--------DIDECSLSDG-LCPHGQCVNVI 1133
            R                 G E  + GT  E        D DEC L  G LC H  C+N +
Sbjct: 566  RPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQH-LCINTV 624

Query: 1134 GAFQCSCHAGFQSTPDRQGC---------------------------------VDINECR 1160
            G++ C+C  GF    D + C                                    N C+
Sbjct: 625  GSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCK 684

Query: 1161 VQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQG-HCTNMPGGH 1219
              NG C   C    GS  CSC  GY++M DG +C D++EC  +   C +G HC N  G  
Sbjct: 685  -DNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSF 743

Query: 1220 RC----LCYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVC----HCQLGYM 1270
             C     C  G+ A  D   C DVDEC +  H C  G  C+NTKGSF C     C  G++
Sbjct: 744  HCYKALTCEPGY-ALKD-GECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFL 801

Query: 1271 VRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCR-----CLPGW--VGDGFECHDLD 1323
             +     C D++EC      C    SC+N  GS++C+     C  G+    DG +C D++
Sbjct: 802  -QDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVN 860

Query: 1324 ECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF--FCEDRDEC-AENVDLCDNGQCLN 1380
            EC +  HRC     C N+PGSYRC C+ GF  D F   C D +EC A    LC +  C N
Sbjct: 861  ECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH-TCEN 919

Query: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1440
              G YRC C  GF    D + C+DV+EC +   C+   C N+ G ++C C  GY+L   G
Sbjct: 920  TLGSYRCSCASGFLLAADGKRCEDVNEC-EAQRCS-QECANIYGSYQCYCRQGYQLAEDG 977

Query: 1441 GNCTDINECADPVNCI-NGVCINTPGSYLCSCP-QDFELNPSGVGCVDTRAGNCFLETHD 1498
              CTDI+ECA     +    C+N PGSY C+CP Q + +  +G  C D     C L TH+
Sbjct: 978  HTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD--VDECALGTHN 1035



 Score =  253 bits (645), Expect = 2e-66
 Identities = 211/662 (31%), Positives = 286/662 (43%), Gaps = 85/662 (12%)

Query: 2152 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNT-----EGSYLCTCPAGYTLREDGAMCR 2206
            C D    GL +  E    C  NP L  + C++      EG      P      E  A  R
Sbjct: 518  CCDCCGLGLRVRAEG-QSCESNPNL-GYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPR 575

Query: 2207 DVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG 2266
             V E     ++  + G E +                LP S  G  D +EC   P      
Sbjct: 576  RVSEAEMAGREALSLGTEAE----------------LPNSLPG-DDQDECLLLPGELCQH 618

Query: 2267 RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT------ 2320
             C+NT GS+ C C  GF        C      P      +   +S  S   + T      
Sbjct: 619  LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLP 678

Query: 2321 RAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEG---RDVDECRMLAHLCAHG 2377
            +   C    +  GP  ++C   G SA     P G    A+G    D++EC    H C+ G
Sbjct: 679  QPNTC----KDNGPCKQVCSTVGGSAICSCFP-GYAIMADGVSCEDINECVTDLHTCSRG 733

Query: 2378 E-CINSLGSFRCH----CQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCS 2430
            E C+N+LGSF C+    C+ GY        C D+DEC+     C   FLC+NTKGSF C 
Sbjct: 734  EHCVNTLGSFHCYKALTCEPGYA--LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQ 791

Query: 2431 ----CPRGYLLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTCR-----CPPGF--T 2477
                C  G+L + +G  C D++ECTS    C+  F C+NTVG++TC+     C  G+  +
Sbjct: 792  ARQRCMDGFLQDPEGN-CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHAS 850

Query: 2478 QHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC-DGPH 2536
                 C D +EC      CG    CHN PGS+RC+C  GF   + G GC DVNEC   P 
Sbjct: 851  DDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPG 910

Query: 2537 R-CQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVC 2595
            R CQH C+N LG YRCSC  GF   +   +C D NEC      C S  C N  G ++C C
Sbjct: 911  RLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ--RC-SQECANIYGSYQCYC 967

Query: 2596 PSGFDFDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCP-QGYFRAGQGH-CVSGL 2652
              G+   +    C ++DECA   G  C++ C N PG + C CP QGY     G  C    
Sbjct: 968  RQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVD 1027

Query: 2653 GFSPGPQDTPDKE---ELLSSEAC--YECKINGLS-PRDRPRRSAHRDHQVNLATLDSEA 2706
              + G  +  + E    +  S  C  +EC  N +   + +  R+   D    L   +S A
Sbjct: 1028 ECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDF---LECQNSPA 1084

Query: 2707 LLT---LGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFF---RMHHLRGVSS 2760
             +T   L      L  A  I  + PA       I   I++GNE+G+F   R++   GV  
Sbjct: 1085 RITHYQLNFQTGLLVPAH-IFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVY 1143

Query: 2761 LQ 2762
            LQ
Sbjct: 1144 LQ 1145



 Score =  253 bits (645), Expect = 2e-66
 Identities = 171/466 (36%), Positives = 208/466 (44%), Gaps = 70/466 (15%)

Query: 1071 DVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC---------EDIDECSLS- 1120
            D DEC   P       C NT GSY C C PG  L   G  C         E   E +L  
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 1121 ----------------------DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE 1158
                                  +G C    C  V G+  CSC  G+    D   C DINE
Sbjct: 664  EFSQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGYAIMADGVSCEDINE 722

Query: 1159 CRVQNGGCD--VHCINTEGSYRC----SCGQGYSLMPDGRACADVDECEENPRVCDQGH- 1211
            C      C    HC+NT GS+ C    +C  GY+L  DG  C DVDEC      C  G  
Sbjct: 723  CVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK-DGE-CEDVDECAMGTHTCQPGFL 780

Query: 1212 CTNMPGGHRCL----CYDGFMATPDMRTCVDVDECDLNPHICLHG-DCENTKGSFVCH-- 1264
            C N  G   C     C DGF+  P+   CVD++EC      C  G  C NT GS+ C   
Sbjct: 781  CQNTKGSFYCQARQRCMDGFLQDPE-GNCVDINECTSLSEPCRPGFSCINTVGSYTCQRN 839

Query: 1265 ---CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGF--EC 1319
               C  GY      T C DV+ECE G H C     C N+PGS+ C C  G+  D F   C
Sbjct: 840  PLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGC 899

Query: 1320 HDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQ 1377
             D++EC +   R   +  C N  GSYRC+C  GF  A DG  CED +EC      C   +
Sbjct: 900  IDVNECWASPGRLC-QHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC--EAQRCSQ-E 955

Query: 1378 CLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN--LCAFGSCENLPGMFRCIC-NGGY 1434
            C N  G Y+C C  G+   ED   C D+DECAQG   LC F  C N+PG ++C C   GY
Sbjct: 956  CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTF-RCLNVPGSYQCACPEQGY 1014

Query: 1435 ELDRGGGNCTDINECA-DPVNCING-VCINTPGSYLC---SCPQDF 1475
             +   G +C D++ECA    NC     C N  GS+ C    CP ++
Sbjct: 1015 TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1060



 Score =  242 bits (617), Expect = 4e-63
 Identities = 165/483 (34%), Positives = 217/483 (44%), Gaps = 70/483 (14%)

Query: 868  DDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC--------VDVRLEPCFL 919
            DD +EC   PG      C+NT GS+ C C  G  L   GR C         +   EP   
Sbjct: 603  DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 920  RWDEDECGVTLP------------GKYRM--------DVCCCSIGAVWGVECEACPD-PE 958
                     T+P            G  +          +C C  G     +  +C D  E
Sbjct: 663  SEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINE 722

Query: 959  SLEFASLCPRG------LG-FASRDFLSGRPFY-------KDVNECKVFPGLCTHG-TCR 1003
             +     C RG      LG F     L+  P Y       +DV+EC +    C  G  C+
Sbjct: 723  CVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQ 782

Query: 1004 NTVGSFHCA----CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECE---- 1054
            NT GSF+C     C  GF  D  E NC DI+EC    + C  G +C+NT GS+ C+    
Sbjct: 783  NTKGSFYCQARQRCMDGFLQDP-EGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 841

Query: 1055 -CFPGYESGFMLMKNCMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE 1112
             C  GY +     K C+DV+EC      C  G  C N  GSY+C C  G +  A G  C 
Sbjct: 842  ICARGYHASDDGTK-CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI 900

Query: 1113 DIDECSLSDG-LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCI 1171
            D++EC  S G LC H  C N +G+++CSC +GF    D + C D+NEC  Q   C   C 
Sbjct: 901  DVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECA 957

Query: 1172 NTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYD-GFMAT 1230
            N  GSY+C C QGY L  DG  C D+DEC +   +     C N+PG ++C C + G+  T
Sbjct: 958  NIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMT 1017

Query: 1231 PDMRTCVDVDECDLNPHICLHGD-CENTKGSFVC---HCQLGYM----VRKGATGCSDVD 1282
             + R+C DVDEC L  H C   + C N +GSF C    C   Y+     +   T C D  
Sbjct: 1018 ANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFL 1077

Query: 1283 ECE 1285
            EC+
Sbjct: 1078 ECQ 1080



 Score =  241 bits (615), Expect = 7e-63
 Identities = 181/558 (32%), Positives = 232/558 (41%), Gaps = 111/558 (19%)

Query: 1969 DIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
            D DEC   P       C N+ GS+ C C PGF L D+G  C                   
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTC------------------- 644

Query: 2029 PKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNEC 2088
                           RP EG   P    PQE  A   E        +P P       N C
Sbjct: 645  ---------------RP-EGH-PPQPEAPQE-PALKSEFSQVASNTIPLP---LPQPNTC 683

Query: 2089 AENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVG-HPCGQGT-CTNVIG 2146
             +N G C   VC    GS  C C  GY++   G++C D +EC    H C +G  C N +G
Sbjct: 684  KDN-GPCKQ-VCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLG 741

Query: 2147 GFECACADGFEPGLMMT---CEDIDECSLNPLLC--AFRCHNTEGSYLCT----CPAGYT 2197
             F C  A   EPG  +    CED+DEC++    C   F C NT+GS+ C     C  G+ 
Sbjct: 742  SFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF- 800

Query: 2198 LREDGAMCRDVDECADGQQDCHARGMECKNLIGTFAC-----VCPPGMRPLPGSGEGCTD 2252
            L++    C D++EC    + C   G  C N +G++ C     +C  G       G  C D
Sbjct: 801  LQDPEGNCVDINECTSLSEPCRP-GFSCINTVGSYTCQRNPLICARGYHA-SDDGTKCVD 858

Query: 2253 DNECHAQPDLCVNGR-CVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRS 2311
             NEC      C  G+ C N  GS+RCDC  GFQ       C D+                
Sbjct: 859  VNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVN--------------- 903

Query: 2312 LSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGR---DVDECR 2368
                       EC    GR     CE        +YR  C  G    A+G+   DV+EC 
Sbjct: 904  -----------ECWASPGRLCQHTCENT----LGSYRCSCASGFLLAADGKRCEDVNECE 948

Query: 2369 MLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQ-VPKPCTFLCKNTKGSF 2427
              A  C+  EC N  GS++C+C+ GY       TC D+DEC+Q     CTF C N  GS+
Sbjct: 949  --AQRCSQ-ECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSY 1005

Query: 2428 LCSCP-RGYLLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTC---RCPPGFTQ--- 2478
             C+CP +GY +  +GR+CKD+DEC    HNC     C N  G+F C    CPP + Q   
Sbjct: 1006 QCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSK 1065

Query: 2479 ---HHQACFDNDECSAQP 2493
                   C D  EC   P
Sbjct: 1066 TKCERTTCHDFLECQNSP 1083



 Score =  234 bits (597), Expect = 9e-61
 Identities = 194/681 (28%), Positives = 268/681 (39%), Gaps = 139/681 (20%)

Query: 1590 CPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCV-------CPAEYLQVNGG 1642
            C  G   +     C +I E  T   +C       T   + CV       C A  L    G
Sbjct: 446  CAAGQQWAIDNDECLEIPESGTEDNVC------RTAQRHCCVSYLQEKSCMAGVLGAKEG 499

Query: 1643 NNCMDMRKSVC----FRHYNGTCQNELAFNVTRKMCCCSYNIGQAWN------------- 1685
              C       C    ++     C   L      + C  + N+G   N             
Sbjct: 500  ETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPL 559

Query: 1686 ------RPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPL---DIDECGEIPAICANGI 1736
                  RP E    P       + G +A    T+      L   D DEC  +P      +
Sbjct: 560  IVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHL 619

Query: 1737 CINQIGSFRCECPAGFNYNSILLACEDVDECGSRESP----------------------- 1773
            CIN +GS+ C C  GF+       C         E+P                       
Sbjct: 620  CINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQ 679

Query: 1774 ---CQQNAD----CINIPGSYRCKCTRGYK-LSPGGACVGRNECREIPNVCSHGD-CMDT 1824
               C+ N      C  + GS  C C  GY  ++ G +C   NEC    + CS G+ C++T
Sbjct: 680  PNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNT 739

Query: 1825 EGSYMC----LCHRGFQASADQTLCMDIDEC--DRQPCGNG-TCKNIIGSYNC----LCF 1873
             GS+ C     C  G+     +  C D+DEC      C  G  C+N  GS+ C     C 
Sbjct: 740  LGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCM 797

Query: 1874 PGFVVTHNGDCVDFDECTTLVGQVCRFG-HCLNTAGSFHC-----LCQDGFELTADGKNC 1927
             GF+    G+CVD +ECT+L  + CR G  C+NT GS+ C     +C  G+  + DG  C
Sbjct: 798  DGFLQDPEGNCVDINECTSL-SEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKC 856

Query: 1928 VDTNECLSLAGTCLPG-TCQNLEGSFRCICPPGFQVQS--DHCIDIDECSEEPNLCLFGT 1984
            VD NEC +    C  G  C NL GS+RC C  GFQ  +    CID++EC   P      T
Sbjct: 857  VDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHT 916

Query: 1985 CTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKR 2044
            C N+ GS++C C  GF+L+ +G RC D  +       EA +CS   A      +C C  R
Sbjct: 917  CENTLGSYRCSCASGFLLAADGKRCEDVNEC------EAQRCSQECANIYGSYQCYC--R 968

Query: 2045 PGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTD 2104
             G                   +L   GH           D++ECA+  G+     C+N  
Sbjct: 969  QG------------------YQLAEDGHTCT--------DIDECAQGAGILCTFRCLNVP 1002

Query: 2105 GSFRCECP-FGYSLDFTGINCVDTDECSVG-HPCGQG-TCTNVIGGFEC---ACADGF-- 2156
            GS++C CP  GY++   G +C D DEC++G H C +  TC N+ G F C    C   +  
Sbjct: 1003 GSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQ 1062

Query: 2157 ---EPGLMMTCEDIDECSLNP 2174
                     TC D  EC  +P
Sbjct: 1063 VSKTKCERTTCHDFLECQNSP 1083



 Score =  225 bits (573), Expect = 5e-58
 Identities = 211/715 (29%), Positives = 281/715 (39%), Gaps = 151/715 (21%)

Query: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ--VQSDHCIDIDECSEEPNLCLFGT-- 1984
            D N   S+  +   G+ ++L       C  G Q  + +D C++I E   E N+C      
Sbjct: 422  DPNSVHSIPRSSPEGSTKDL---IETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRH 478

Query: 1985 -CTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCF----------------TRFEAGKC- 2026
             C +      C+   G + +  G  C       C                  R E   C 
Sbjct: 479  CCVSYLQEKSCMA--GVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCE 536

Query: 2027 ---SVPKAFNTTKTRCCCS---------KRPGEGWGDPCELCPQEGSAAFQELCPFGHGA 2074
               ++    N     CC           +RP E    P  +   E   A +E    G  A
Sbjct: 537  SNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRV--SEAEMAGREALSLGTEA 594

Query: 2075 VPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINC---------- 2124
                    +D +EC   PG     +C+NT GS+ C C  G+SL   G  C          
Sbjct: 595  ELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPE 654

Query: 2125 -----------------------VDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM 2161
                                      + C    PC Q  C+ V G   C+C  G+   +M
Sbjct: 655  APQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGY--AIM 711

Query: 2162 ---MTCEDIDECSLNPLLCAF--RCHNTEGSYLC----TCPAGYTLREDGAMCRDVDECA 2212
               ++CEDI+EC  +   C+    C NT GS+ C    TC  GY L++    C DVDECA
Sbjct: 712  ADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKD--GECEDVDECA 769

Query: 2213 DGQQDCHARGMECKNLIGTFACV----CPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-R 2267
             G   C   G  C+N  G+F C     C  G    P     C D NEC +  + C  G  
Sbjct: 770  MGTHTCQP-GFLCQNTKGSFYCQARQRCMDGFLQDPEGN--CVDINECTSLSEPCRPGFS 826

Query: 2268 CVNTAGSFRCD-----CDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRA 2322
            C+NT GS+ C      C  G+  S   T+C D+                           
Sbjct: 827  CINTVGSYTCQRNPLICARGYHASDDGTKCVDVN-------------------------- 860

Query: 2323 ECCCGGGR-GWGPRCELCPLPGTSAYRKLCPHGSGYTAEGR---DVDEC-RMLAHLCAHG 2377
            EC  G  R G G  C    LPG+  YR  C  G    A GR   DV+EC      LC H 
Sbjct: 861  ECETGVHRCGEGQVCH--NLPGS--YRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH- 915

Query: 2378 ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLL 2437
             C N+LGS+RC C +G+   A    C D++EC    + C+  C N  GS+ C C +GY L
Sbjct: 916  TCENTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQECANIYGSYQCYCRQGYQL 973

Query: 2438 EEDGRTCKDLDECTSRQHN-CQFLCVNTVGAFTCRCPP-GFTQ--HHQACFDNDECSAQP 2493
             EDG TC D+DEC       C F C+N  G++ C CP  G+T   + ++C D DEC+   
Sbjct: 974  AEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGT 1033

Query: 2494 GPCGAHGHCHNTPGSFRC---ECHQGFTLVSSGH----GCEDVNEC-DGPHRCQH 2540
              C     CHN  GSFRC   EC   +  VS        C D  EC + P R  H
Sbjct: 1034 HNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPARITH 1088



 Score =  222 bits (566), Expect = 4e-57
 Identities = 167/519 (32%), Positives = 218/519 (42%), Gaps = 78/519 (15%)

Query: 1806 RNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDID-----ECDRQPCGNGT 1860
            ++EC  +P       C++T GSY C C  GF    D   C         E  ++P     
Sbjct: 605  QDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSE 664

Query: 1861 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL 1920
               +  +   L  P         C D   C  +         C    GS  C C  G+ +
Sbjct: 665  FSQVASNTIPLPLP-----QPNTCKDNGPCKQV---------CSTVGGSAICSCFPGYAI 710

Query: 1921 TADGKNCVDTNECLSLAGTCLPGT-CQNLEGSFRCI----CPPGFQVQSDHCIDIDECSE 1975
             ADG +C D NEC++   TC  G  C N  GSF C     C PG+ ++   C D+DEC+ 
Sbjct: 711  MADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAM 770

Query: 1976 EPNLCLFG-TCTNSPGSFQCL----CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPK 2030
              + C  G  C N+ GSF C     C  GF+    G+ C D  +  C +  E   C    
Sbjct: 771  GTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDINE--CTSLSEP--CRPGF 825

Query: 2031 AFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSRE--DVNEC 2088
            +   T     C + P                     +C  G+ A    DD  +  DVNEC
Sbjct: 826  SCINTVGSYTCQRNP--------------------LICARGYHA---SDDGTKCVDVNEC 862

Query: 2089 AENPGVCTNG-VCVNTDGSFRCECPFGYSLDFTGINCVDTDEC--SVGHPCGQGTCTNVI 2145
                  C  G VC N  GS+RC+C  G+  D  G  C+D +EC  S G  C Q TC N +
Sbjct: 863  ETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC-QHTCENTL 921

Query: 2146 GGFECACADGFEPGLM-MTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAM 2204
            G + C+CA GF        CED++EC      C+  C N  GSY C C  GY L EDG  
Sbjct: 922  GSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHT 979

Query: 2205 CRDVDECADGQQD-CHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLC 2263
            C D+DECA G    C  R   C N+ G++ C CP     +  +G  C D +EC      C
Sbjct: 980  CTDIDECAQGAGILCTFR---CLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNC 1036

Query: 2264 VNGR-CVNTAGSFRC---DCDEGF-QPSPT---LTECHD 2294
                 C N  GSFRC   +C   + Q S T    T CHD
Sbjct: 1037 SEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHD 1075



 Score =  214 bits (545), Expect = 1e-54
 Identities = 179/573 (31%), Positives = 229/573 (39%), Gaps = 120/573 (20%)

Query: 237  IPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGAC 295
            +PN   G   D DEC  +PG LCQ   C+N VGS+HC C  G  L D    C        
Sbjct: 596  LPNSLPG--DDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRP------ 646

Query: 296  FSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPEL-CPPRGSNEFQQLCAQRLPLLP 354
                          GH                 P PE    P   +EF Q+ +  +PL  
Sbjct: 647  -------------EGH----------------PPQPEAPQEPALKSEFSQVASNTIPLPL 677

Query: 355  GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRH 414
              P                  GP +          I S  PG + +      + I+ C  
Sbjct: 678  PQPNTC------------KDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVT 725

Query: 415  FTNLCLNG-RCLPTPSSYRC----ECNVGYTQDVRGECIDVDECT--SSPCHHGD-CVNI 466
              + C  G  C+ T  S+ C     C  GY     GEC DVDEC   +  C  G  C N 
Sbjct: 726  DLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK-DGECEDVDECAMGTHTCQPGFLCQNT 784

Query: 467  PGTYHC----RCYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQC-----VC 516
             G+++C    RC  GF   P    CVD++EC      C  G  C+NT GS+ C     +C
Sbjct: 785  KGSFYCQARQRCMDGFLQDPEGN-CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLIC 843

Query: 517  NAGFELSPDGKNCVDHNECATST-MCVNG-VCLNEDGSFSCLCKPGFLLAPGGHYCMDID 574
              G+  S DG  CVD NEC T    C  G VC N  GS+ C CK GF     G  C+D++
Sbjct: 844  ARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVN 903

Query: 575  EC-QTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPF 633
            EC  +PG      C NT GS+RC C  G  +  DG+ C D +         E   C++  
Sbjct: 904  ECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVN-------ECEAQRCSQ-- 954

Query: 634  PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDP 690
                   EC                 A     +Q  C  G  +  DG    DI+ECA   
Sbjct: 955  -------EC-----------------ANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGA 990

Query: 691  EVCANGVCENLRGSYRCVC-NLGYEAGASGKDCTDVDECALNSLLCDNG-WCQNSPGSYS 748
             +     C N+ GSY+C C   GY   A+G+ C DVDECAL +  C     C N  GS+ 
Sbjct: 991  GILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFR 1050

Query: 749  C---SCPPGFHFWQDTE----ICKDVDECLSSP 774
            C    CPP +     T+     C D  EC +SP
Sbjct: 1051 CLRFECPPNYVQVSKTKCERTTCHDFLECQNSP 1083



 Score =  206 bits (523), Expect = 3e-52
 Identities = 205/747 (27%), Positives = 273/747 (36%), Gaps = 173/747 (23%)

Query: 1098 CPPGHELTAKGTACEDIDECSLSDGLCPHGQ---CVNVIGAFQCSCHAGFQSTPDRQGC- 1153
            C  G +       C +I E    D +C   Q   CV+ +   + SC AG     + + C 
Sbjct: 446  CAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQ--EKSCMAGVLGAKEGETCG 503

Query: 1154 -VDINECRVQ--NGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD------------VD 1198
              D + C +      CD             CG G  +  +G++C              + 
Sbjct: 504  AEDNDSCGISLYKQCCDC------------CGLGLRVRAEGQSCESNPNLGYPCNHVMLS 551

Query: 1199 ECE-ENPRVCDQGHCTNMPG------------GHRCLCYDGFMATPDMRTCVDVDECDLN 1245
             CE E P +  +      P             G   L        P+     D DEC L 
Sbjct: 552  CCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLL 611

Query: 1246 P-HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGH--------------- 1289
            P  +C H  C NT GS+ C C  G+ ++       D   C   GH               
Sbjct: 612  PGELCQHL-CINTVGSYHCACFPGFSLQ------DDGRTCRPEGHPPQPEAPQEPALKSE 664

Query: 1290 ---------------------NCDSHASCLNIPGSFSCRCLPGW--VGDGFECHDLDECV 1326
                                 N      C  + GS  C C PG+  + DG  C D++ECV
Sbjct: 665  FSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECV 724

Query: 1327 SQEHRCSPRGDCLNVPGSYRC----TCRQGFAGDGFFCEDRDECAENVDLCDNG-QCLNA 1381
            +  H CS    C+N  GS+ C    TC  G+A     CED DECA     C  G  C N 
Sbjct: 725  TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNT 784

Query: 1382 PGGYRCE----CEMGF--DPTEDHRACQDVDECAQ-GNLCAFG-SCENLPGMFRC----- 1428
             G + C+    C  GF  DP  +   C D++EC      C  G SC N  G + C     
Sbjct: 785  KGSFYCQARQRCMDGFLQDPEGN---CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 841

Query: 1429 ICNGGYELDRGGGNCTDINECADPVN-CING-VCINTPGSYLCSCPQDFELNPSGVGCVD 1486
            IC  GY     G  C D+NEC   V+ C  G VC N PGSY C C   F+ +  G GC+D
Sbjct: 842  ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 901

Query: 1487 TRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTT-EYRTL 1545
                                            C  S GR   + CE     NT   YR  
Sbjct: 902  VN-----------------------------ECWASPGRLCQHTCE-----NTLGSYRCS 927

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICED 1605
            C    GF         ED++EC+     C   +C N +GS+QC C  GY L+E    C D
Sbjct: 928  C--ASGFLLAADGKRCEDVNECE--AQRC-SQECANIYGSYQCYCRQGYQLAEDGHTCTD 982

Query: 1606 IDECSTHSGICGPGTCYNTLGNYTCVCPAE-YLQVNGGNNCMDMRKSVCFRHYNGTCQNE 1664
            IDEC+  +GI     C N  G+Y C CP + Y     G +C D+ +  C    +   + E
Sbjct: 983  IDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE--CALGTHNCSEAE 1040

Query: 1665 LAFNVTRKMCC----CSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLT----DIHT 1716
               N+     C    C  N  Q     CE      +  +  L    +P  +T    +  T
Sbjct: 1041 TCHNIQGSFRCLRFECPPNYVQVSKTKCER-----TTCHDFLECQNSPARITHYQLNFQT 1095

Query: 1717 G--KPLDIDECGEIPAICANGICINQI 1741
            G   P  I   G  PA   + I +N I
Sbjct: 1096 GLLVPAHIFRIGPAPAFTGDTIALNII 1122



 Score =  201 bits (510), Expect = 1e-50
 Identities = 174/550 (31%), Positives = 221/550 (40%), Gaps = 112/550 (20%)

Query: 572  DIDECQT-PGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC------------VDTHVRS 618
            D DEC   PG      C NT GS+ C C  G ++  DGR C             +  ++S
Sbjct: 604  DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 619  TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITT 678
              +  +   +   P P   T         D+G   PC+   +         C  G  I  
Sbjct: 664  E-FSQVASNTIPLPLPQPNTCK-------DNG---PCKQVCSTVGGSAICSCFPGYAIMA 712

Query: 679  DG---RDINECALDPEVCANGV-CENLRGSYRCVCNLGYEAGASGKD--CTDVDECALNS 732
            DG    DINEC  D   C+ G  C N  GS+ C   L  E G + KD  C DVDECA+ +
Sbjct: 713  DGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGT 772

Query: 733  LLCDNGW-CQNSPGSYSCS----CPPGFHFWQDTE-ICKDVDEC--LSSPCVSGV-CRNL 783
              C  G+ CQN+ GS+ C     C  GF   QD E  C D++EC  LS PC  G  C N 
Sbjct: 773  HTCQPGFLCQNTKGSFYCQARQRCMDGF--LQDPEGNCVDINECTSLSEPCRPGFSCINT 830

Query: 784  AGSYTCK-----CGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATL 838
             GSYTC+     C  G      GT C+D  +           CE  +       + C  L
Sbjct: 831  VGSYTCQRNPLICARGYHASDDGTKCVDVNE-----------CETGVHRCG-EGQVCHNL 878

Query: 839  GAAWGSPCERCEIDPACARGFARMT-GVTCDDVNECESFPGVCPNGRCVNTAGSFRCECP 897
              ++     RC+    C  GF R   G  C DVNEC + PG      C NT GS+RC C 
Sbjct: 879  PGSY-----RCD----CKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCA 929

Query: 898  EGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDP 957
             G +L A G+ C DV    C  +    EC   + G Y+   C C  G     +   C D 
Sbjct: 930  SGFLLAADGKRCEDV--NECEAQRCSQEC-ANIYGSYQ---CYCRQGYQLAEDGHTCTDI 983

Query: 958  ESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCAC-AGG 1016
            +       C +G G                        LCT   C N  GS+ CAC   G
Sbjct: 984  DE------CAQGAGI-----------------------LCTF-RCLNVPGSYQCACPEQG 1013

Query: 1017 FALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFEC---ECFPGY---ESGFMLMKNC 1069
            + + A  R+C D+DEC +    C +  TC N  GSF C   EC P Y            C
Sbjct: 1014 YTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTC 1073

Query: 1070 MDVDECARDP 1079
             D  EC   P
Sbjct: 1074 HDFLECQNSP 1083



 Score =  199 bits (506), Expect = 3e-50
 Identities = 138/403 (34%), Positives = 186/403 (46%), Gaps = 70/403 (17%)

Query: 424  CLPTPSSYRCECNVGYTQDVRG-ECIDVDECTSS--PCHHGD-CVNIPGTYHC----RCY 475
            C     S  C C  GY     G  C D++EC +    C  G+ CVN  G++HC     C 
Sbjct: 693  CSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCE 752

Query: 476  PGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQCV----CNAGFELSPDGKNCV 530
            PG+        C DVDEC +    C  G  C NT+GSF C     C  GF   P+G NCV
Sbjct: 753  PGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCV 809

Query: 531  DHNECAT-STMCVNGV-CLNEDGSFSC-----LCKPGFLLAPGGHYCMDIDECQTPGI-- 581
            D NEC + S  C  G  C+N  GS++C     +C  G+  +  G  C+D++EC+T G+  
Sbjct: 810  DINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECET-GVHR 868

Query: 582  CVNGH-CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKS 640
            C  G  C N  GS+RC C  G      GR C+D +                         
Sbjct: 869  CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE------------------------ 904

Query: 641  ECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANGV 697
              C A+P    G  CQ         ++  C+SG  +  DG+   D+NEC  + + C+   
Sbjct: 905  --CWASP----GRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC--EAQRCSQE- 955

Query: 698  CENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCP-PGFH 756
            C N+ GSY+C C  GY+    G  CTD+DECA  + +     C N PGSY C+CP  G+ 
Sbjct: 956  CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYT 1015

Query: 757  FWQDTEICKDVDECL--SSPCVSG-VCRNLAGSYTC---KCGP 793
               +   CKDVDEC   +  C     C N+ GS+ C   +C P
Sbjct: 1016 MTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPP 1058



 Score =  175 bits (444), Expect = 5e-43
 Identities = 152/480 (31%), Positives = 198/480 (41%), Gaps = 97/480 (20%)

Query: 489  DVDECIV-SGGLC-HLGRCVNTEGSFQCVCNAGFELSPDGKNC----------------- 529
            D DEC++  G LC HL  C+NT GS+ C C  GF L  DG+ C                 
Sbjct: 604  DQDECLLLPGELCQHL--CINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPAL 661

Query: 530  -VDHNECATSTMCV----------NG----VCLNEDGSFSCLCKPGFLLAPGGHYCMDID 574
              + ++ A++T+ +          NG    VC    GS  C C PG+ +   G  C DI+
Sbjct: 662  KSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDIN 721

Query: 575  ECQTP-GICVNG-HCTNTEGSFRC---------------------QCLGGLAVGTDGRVC 611
            EC T    C  G HC NT GSF C                     +C  G      G +C
Sbjct: 722  ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLC 781

Query: 612  VDTHVRSTCYG--AIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQAL 669
             +T     C        G    P    V  +EC   +     G  C       + +   L
Sbjct: 782  QNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 841

Query: 670  -CSSGLGITTDGR---DINECALDPEVCANG-VCENLRGSYRCVCNLGYEAGASGKDCTD 724
             C+ G   + DG    D+NEC      C  G VC NL GSYRC C  G++  A G+ C D
Sbjct: 842  ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 901

Query: 725  VDEC-ALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNL 783
            V+EC A    LC +  C+N+ GSY CSC  GF    D + C+DV+EC +  C S  C N+
Sbjct: 902  VNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRC-SQECANI 959

Query: 784  AGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGAS-LRSECCATLGAAW 842
             GSY C C  G +L   G  C D         I E       QGA  L +  C  +  ++
Sbjct: 960  YGSYQCYCRQGYQLAEDGHTCTD---------IDEC-----AQGAGILCTFRCLNVPGSY 1005

Query: 843  GSPCERCEIDPACARGFA-RMTGVTCDDVNECESFPGVCPNGR-CVNTAGSFRC---ECP 897
               C          +G+     G +C DV+EC      C     C N  GSFRC   ECP
Sbjct: 1006 QCACPE--------QGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECP 1057



 Score =  157 bits (398), Expect = 1e-37
 Identities = 140/508 (27%), Positives = 197/508 (38%), Gaps = 101/508 (19%)

Query: 1361 EDRDECAENV-DLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ---------------- 1403
            +D+DEC     +LC +  C+N  G Y C C  GF   +D R C+                
Sbjct: 603  DDQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPAL 661

Query: 1404 --DVDECA---------QGNLCAFGS-----CENLPGMFRCICNGGYELDRGGGNCTDIN 1447
              +  + A         Q N C         C  + G   C C  GY +   G +C DIN
Sbjct: 662  KSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDIN 721

Query: 1448 EC-ADPVNCINGV-CINTPGSYLC----SCPQDFELNPSGVGCVDTRAGNCFLETHDRGD 1501
            EC  D   C  G  C+NT GS+ C    +C   + L       VD     C + TH    
Sbjct: 722  ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVD----ECAMGTH---- 773

Query: 1502 SGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVIL 1561
               +C        T+ S  C                   + R  C  G    P    V  
Sbjct: 774  ---TCQPGFLCQNTKGSFYC-------------------QARQRCMDGFLQDPEGNCV-- 809

Query: 1562 EDIDECQELPGLCQGG-DCVNTFGSFQCE-----CPPGYHLSEHTRICEDIDECSTHSGI 1615
             DI+EC  L   C+ G  C+NT GS+ C+     C  GYH S+    C D++EC T    
Sbjct: 810  -DINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHR 868

Query: 1616 CGPG-TCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMC 1674
            CG G  C+N  G+Y C C A + +   G  C+D+ +  C+      CQ+     +    C
Sbjct: 869  CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE--CWASPGRLCQHTCENTLGSYRC 926

Query: 1675 CCS------------YNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDI 1722
             C+             ++ +   + C      I   YQ  C  Q      D HT    DI
Sbjct: 927  SCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYC-RQGYQLAEDGHT--CTDI 983

Query: 1723 DECGEIPAICANGICINQIGSFRCECP-AGFNYNSILLACEDVDECGSRESPCQQNADCI 1781
            DEC +   I     C+N  GS++C CP  G+   +   +C+DVDEC      C +   C 
Sbjct: 984  DECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCH 1043

Query: 1782 NIPGSYRCKCTRGYKLSPGGACVGRNEC 1809
            NI GS+RC     ++  P    V + +C
Sbjct: 1044 NIQGSFRC---LRFECPPNYVQVSKTKC 1068



 Score =  151 bits (382), Expect = 8e-36
 Identities = 136/455 (29%), Positives = 181/455 (39%), Gaps = 74/455 (16%)

Query: 237  IPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF 296
            +P      C+D   C+ V        C  + GS  C C  G+ +     +CED     C 
Sbjct: 675  LPLPQPNTCKDNGPCKQV--------CSTVGGSAICSCFPGYAIMADGVSCEDINE--CV 724

Query: 297  SVLF----GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPL 352
            + L     G  C   L   +  +   C+ G     G   ++            CA     
Sbjct: 725  TDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDV----------DECAM---- 770

Query: 353  LPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDIC 412
              G     PG L   + G        R         G      GN           I+ C
Sbjct: 771  --GTHTCQPGFLCQNTKGSFYCQARQRCMD------GFLQDPEGNC--------VDINEC 814

Query: 413  RHFTNLCLNG-RCLPTPSSYRCE-----CNVGY-TQDVRGECIDVDECTSSPCHHGD--- 462
               +  C  G  C+ T  SY C+     C  GY   D   +C+DV+EC +     G+   
Sbjct: 815  TSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQV 874

Query: 463  CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
            C N+PG+Y C C  GFQ     + C+DV+EC  S G      C NT GS++C C +GF L
Sbjct: 875  CHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLL 934

Query: 523  SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC-QTPGI 581
            + DGK C D NEC       +  C N  GS+ C C+ G+ LA  GH C DIDEC Q  GI
Sbjct: 935  AADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGI 992

Query: 582  CVNGHCTNTEGSFRCQC-LGGLAVGTDGRVCVD-------THVRS---TCYGAIEKGSCA 630
                 C N  GS++C C   G  +  +GR C D       TH  S   TC+       C 
Sbjct: 993  LCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1052

Query: 631  R----PFPGTVTKSECCCANPDHGFGEPCQLCPAK 661
            R    P    V+K++ C     H F E CQ  PA+
Sbjct: 1053 RFECPPNYVQVSKTK-CERTTCHDFLE-CQNSPAR 1085



 Score =  151 bits (381), Expect = 1e-35
 Identities = 125/401 (31%), Positives = 170/401 (42%), Gaps = 57/401 (14%)

Query: 211  CATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGS 269
            C+TVG +      +C   P     G+       +C+D++EC      C  G  CVN +GS
Sbjct: 693  CSTVGGS-----AICSCFP-----GYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGS 742

Query: 270  FHC----RCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCW 325
            FHC     C  G+ L D      D  A    +   G  C       Y     C  R RC 
Sbjct: 743  FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFY-----CQARQRCM 797

Query: 326  AAGPVPELCPPRGS-NEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG 384
                   L  P G+  +  +  +   P  PG    F  +   GS          + NP  
Sbjct: 798  DG----FLQDPEGNCVDINECTSLSEPCRPG----FSCINTVGSY-------TCQRNPL- 841

Query: 385  SDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGR-CLPTPSSYRCECNVGYTQDV 443
                 I + G   S+ GT  ++  ++ C    + C  G+ C   P SYRC+C  G+ +D 
Sbjct: 842  -----ICARGYHASDDGTKCVD--VNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDA 894

Query: 444  RGE-CIDVDECTSSP---CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL 499
             G  CIDV+EC +SP   C H  C N  G+Y C C  GF      + C DV+EC      
Sbjct: 895  FGRGCIDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNEC--EAQR 951

Query: 500  CHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATST-MCVNGVCLNEDGSFSCLC- 557
            C    C N  GS+QC C  G++L+ DG  C D +ECA    +     CLN  GS+ C C 
Sbjct: 952  CS-QECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACP 1010

Query: 558  KPGFLLAPGGHYCMDIDECQ--TPGICVNGHCTNTEGSFRC 596
            + G+ +   G  C D+DEC   T        C N +GSFRC
Sbjct: 1011 EQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRC 1051



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 79/293 (26%), Positives = 108/293 (36%), Gaps = 88/293 (30%)

Query: 58  NVCGSRFHAY----CCPGWRTFPGR----SQCVVP--------ICRRACGEGFCSQPNLC 101
           N  GS FH Y    C PG+    G      +C +         +C+   G  +C      
Sbjct: 738 NTLGS-FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ-- 794

Query: 102 TCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT-----GTVCGQP---ICDR 153
            C DG L    G         +C++   C   S  C+ G++     G+   Q    IC R
Sbjct: 795 RCMDGFLQDPEG---------NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICAR 845

Query: 154 GCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALC 210
           G H   +G +C+  N C              +R G   GQV    C H L G        
Sbjct: 846 GYHASDDGTKCVDVNECETGV----------HRCGE--GQV----C-HNLPG-------- 880

Query: 211 CATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPG-LCQGGSCVNMVGS 269
                      C+        C+ GF  +     C DV+EC A PG LCQ  +C N +GS
Sbjct: 881 --------SYRCD--------CKAGFQRDAFGRGCIDVNECWASPGRLCQ-HTCENTLGS 923

Query: 270 FHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG 322
           + C C  G  L+     CED     C +     RC+ + A  Y   QC C +G
Sbjct: 924 YRCSCASGFLLAADGKRCED--VNECEA----QRCSQECANIYGSYQCYCRQG 970



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 65/244 (26%), Positives = 91/244 (37%), Gaps = 52/244 (21%)

Query: 87   RRACGEGFCSQP-------NLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQK 139
            R+ C +GF   P       N CT       P      G  C ++ +   TC+    +C +
Sbjct: 793  RQRCMDGFLQDPEGNCVDINECTSLSEPCRP------GFSC-INTVGSYTCQRNPLICAR 845

Query: 140  GY----TGTVC--------GQPICDRG--CHNGGRCIGPNRCACVYGFMGPQCERD-YRT 184
            GY     GT C        G   C  G  CHN     G  RC C  GF      R     
Sbjct: 846  GYHASDDGTKCVDVNECETGVHRCGEGQVCHN---LPGSYRCDCKAGFQRDAFGRGCIDV 902

Query: 185  GPCFGQVGPEGCQHQLTGLVCTKALCCAT--VGRAWGLPCE---LCPAQPHP-------- 231
              C+   G   CQH     + +    CA+  +  A G  CE    C AQ           
Sbjct: 903  NECWASPG-RLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYG 961

Query: 232  -----CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCP-VGHRLSDSSA 285
                 CR+G+        C D+DEC    G+     C+N+ GS+ C CP  G+ ++ +  
Sbjct: 962  SYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGR 1021

Query: 286  ACED 289
            +C+D
Sbjct: 1022 SCKD 1025



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 59/237 (24%), Positives = 82/237 (34%), Gaps = 36/237 (15%)

Query: 56   GPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVS 115
            G + CG     +  PG      R  C     R A G G C   N C  + G L       
Sbjct: 865  GVHRCGEGQVCHNLPG----SYRCDCKAGFQRDAFGRG-CIDVNECWASPGRL------- 912

Query: 116  RGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMG 175
                C  +C N  T     C C  G+     G+   D       RC     CA +YG   
Sbjct: 913  ----CQHTCEN--TLGSYRCSCASGFLLAADGKRCEDVNECEAQRC--SQECANIYGSYQ 964

Query: 176  PQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRG 235
              C + Y+               Q  G++CT    C  V  ++   C           +G
Sbjct: 965  CYCRQGYQLAEDGHTCTDIDECAQGAGILCT--FRCLNVPGSYQCACP---------EQG 1013

Query: 236  FIPNIHTGACQDVDECQAVPGLC-QGGSCVNMVGSFHC---RCPVGHRLSDSSAACE 288
            +    +  +C+DVDEC      C +  +C N+ GSF C    CP  + +  S   CE
Sbjct: 1014 YTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY-VQVSKTKCE 1069


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  251 bits (642), Expect = 5e-66
 Identities = 157/414 (37%), Positives = 211/414 (50%), Gaps = 51/414 (12%)

Query: 1030 DECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKN---CMDVDECARDPLLCR-GG 1085
            D CR     C Q  C +T     C CF GY+    L+ +   C DV+EC      CR G 
Sbjct: 178  DRCR-GGGPCKQ-QCRDTGDEVVCSCFVGYQ----LLSDGVSCEDVNECITGSHSCRLGE 231

Query: 1086 TCTNTDGSYKCQ----CPPGHELTAKGTACEDIDECSLSDGLC-PHGQCVNVIGAFQC-- 1138
            +C NT GS++CQ    C  G+ELT +  +C+DIDEC      C P   C N +G+F+C  
Sbjct: 232  SCINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 1139 --SCHAGFQSTPDRQG-CVDINECRVQNGGCDVH--CINTEGSYRC-----SCGQGYSLM 1188
               C +GF    D  G C+DINEC   +  C +   CINTEGSY C     +CG+GY L 
Sbjct: 291  KLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLN 348

Query: 1189 PDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNP- 1246
             +G  C DVDEC      C +GH C N PG  RC C  G+      R CVDV+EC   P 
Sbjct: 349  EEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408

Query: 1247 HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC 1306
             +C H  CENT GS++C C +G+ +      C D++EC     +      C N+ GS+ C
Sbjct: 409  RLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQC 463

Query: 1307 RCLPGWV---GDGFECHDLDECV--SQEHRCSPRGDCLNVPGSYRCTCRQG---FAGDGF 1358
             C  G+     DG  C D+DEC   +  H CS R  C+N+PGS++C+C       A +G 
Sbjct: 464  YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGR 521

Query: 1359 FCEDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG 1411
             C+D DEC   +  C  N  C N  GG+RC   + F+  E++R      +  +G
Sbjct: 522  NCQDIDECVTGIHNCSINETCFNIQGGFRC---LAFECPENYRRSAATQKSKKG 572



 Score =  222 bits (566), Expect = 4e-57
 Identities = 133/366 (36%), Positives = 177/366 (48%), Gaps = 65/366 (17%)

Query: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECE----CF 1056
            CR+T     C+C  G+ L +   +C D++EC      C  G +C+NT GSF C+    C 
Sbjct: 190  CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249

Query: 1057 PGYE------------------------------------------SGFM--LMKNCMDV 1072
             GYE                                          SGF+   + NC+D+
Sbjct: 250  TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDI 309

Query: 1073 DECARDPLLCR-GGTCTNTDGSYKCQ-----CPPGHELTAKGTACEDIDECSLSDGLCPH 1126
            +EC      C  G TC NT+GSY CQ     C  G+ L  +GT C D+DEC+     C  
Sbjct: 310  NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369

Query: 1127 G-QCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG-CDVHCINTEGSYRCSCGQG 1184
            G +CVN  G+F+C C  G+      + CVD+NEC+   G  C   C NT GSY CSC  G
Sbjct: 370  GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429

Query: 1185 YSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGF-MATPDMRTCVDVDECD 1243
            + L  DGR+C D++EC  +P  C Q  C N+ G ++C C  G+ ++  D  TC D+DEC 
Sbjct: 430  FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 1244 L--NPHICLHGDCENTKGSFVCHC-QLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNI 1300
            L    HIC +  C N  GSF C C   GY +      C D+DEC  G HNC  + +C NI
Sbjct: 487  LPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545

Query: 1301 PGSFSC 1306
             G F C
Sbjct: 546  QGGFRC 551



 Score =  216 bits (549), Expect = 3e-55
 Identities = 163/494 (32%), Positives = 216/494 (43%), Gaps = 93/494 (18%)

Query: 2111 CPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPG------LMMTC 2164
            C  G +    G +C  +    VG+ CGQ         F   C    E G      L  T 
Sbjct: 113  CLLGRAAQAQGQSCEYS--LMVGYQCGQV--------FRACCVKSQETGDLDVGGLQETD 162

Query: 2165 E--DIDECSLNPLL---------CAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECAD 2213
            +  +++E   +P L         C  +C +T    +C+C  GY L  DG  C DV+EC  
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT 222

Query: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG------- 2266
            G   C   G  C N +G+F C          G+G   T+DN C    D C +G       
Sbjct: 223  GSHSCRL-GESCINTVGSFRCQRDSSC----GTGYELTEDNSC-KDIDECESGIHNCLPD 276

Query: 2267 -RCVNTAGSFRC----DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
              C NT GSFRC     C  GF     L  C DI +           C S+S        
Sbjct: 277  FICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINE-----------CLSIS-------- 316

Query: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPH-GSGY--TAEGR---DVDECRMLAHLCA 2375
            A C  G               G+   +K  P+ G GY    EG    DVDEC   A  C 
Sbjct: 317  APCPIGH--------TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368

Query: 2376 HG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP-KPCTFLCKNTKGSFLCSCPR 2433
             G  C+NS GSFRC C+ GY  D  +  C+D++EC + P + C   C+NT GS+LCSC  
Sbjct: 369  KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH---QACFDNDECS 2490
            G+ L  DGR+C+D++EC+S    C   C N  G++ C C  G+         C D DEC+
Sbjct: 429  GFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 2491 AQPGPCGAHGHCHNTPGSFRCEC-HQGFTLVSSGHGCEDVNEC-DGPHRC--QHGCQNQL 2546
               G       C N PGSF+C C   G+ L  +G  C+D++EC  G H C     C N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 2547 GGYRC---SCPQGF 2557
            GG+RC    CP+ +
Sbjct: 547  GGFRCLAFECPENY 560



 Score =  213 bits (543), Expect = 2e-54
 Identities = 141/380 (37%), Positives = 182/380 (47%), Gaps = 51/380 (13%)

Query: 2330 RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEG---RDVDECRMLAHLCAHGE-CINSLGS 2385
            RG GP  + C   G       C  G    ++G    DV+EC   +H C  GE CIN++GS
Sbjct: 181  RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 2386 FRCH----CQAGY--TPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLC----SCPR 2433
            FRC     C  GY  T D    +C D+DEC      C   F+C+NT GSF C     C  
Sbjct: 240  FRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR-----CPPGFTQHHQA--CF 2484
            G++ +  G  C D++EC S    C     C+NT G++TC+     C  G+  + +   C 
Sbjct: 297  GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG-PHR-CQHGC 2542
            D DEC+    PCG    C N+PGSFRCEC  G+        C DVNEC   P R C H C
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 2543 QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFD 2602
            +N LG Y CSC  GF        C D NEC+ SP  C S  C N  G ++C C  G+   
Sbjct: 416  ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGYQLS 472

Query: 2603 QALG-GCQEVDECAGRRGP--CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
               G  C+++DECA   G   CSY C N PG F C CP            SG   +P  +
Sbjct: 473  DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-----------SGYRLAPNGR 521

Query: 2660 DTPDKEELLSSEACYECKIN 2679
            +  D +E ++    + C IN
Sbjct: 522  NCQDIDECVT--GIHNCSIN 539



 Score =  197 bits (500), Expect = 2e-49
 Identities = 137/397 (34%), Positives = 186/397 (46%), Gaps = 51/397 (12%)

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943
            +C +T     C C  G  L + G  C DV           +EC +T     R+   C  I
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NEC-ITGSHSCRLGESC--I 234

Query: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHG-TC 1002
              V    C+           S C  G G+   +  S     KD++EC+     C     C
Sbjct: 235  NTVGSFRCQR---------DSSC--GTGYELTEDNS----CKDIDECESGIHNCLPDFIC 279

Query: 1003 RNTVGSFHCA----CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECEC-F 1056
            +NT+GSF C     C  GF  DA   NC DI+EC      C  G TC+NT GS+ C+   
Sbjct: 280  QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1057 PGYESGFMLMKN---CMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE 1112
            P    G+ L +    C+DVDECA     C +G  C N+ GS++C+C  G+        C 
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 1113 DIDECSLSDG-LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCI 1171
            D++EC    G LC H +C N +G++ CSC  GF+ + D + C DINEC   +  C   C 
Sbjct: 399  DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECA 455

Query: 1172 NTEGSYRCSCGQGYSLMP-DGRACADVDEC--EENPRVCDQGHCTNMPGGHRCLC-YDGF 1227
            N  GSY+C C +GY L   DG  C D+DEC       +C    C N+PG  +C C   G+
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGY 514

Query: 1228 MATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVC 1263
               P+ R C D+DEC    H C ++  C N +G F C
Sbjct: 515  RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  187 bits (476), Expect = 1e-46
 Identities = 158/491 (32%), Positives = 211/491 (42%), Gaps = 84/491 (17%)

Query: 1672 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCG---------NQAPGFLTDI----HTGK 1718
            K CC    +G+A     ++C   +   YQ  CG         +Q  G L D+     T K
Sbjct: 107  KRCCHCCLLGRAAQAQGQSCEYSLMVGYQ--CGQVFRACCVKSQETGDL-DVGGLQETDK 163

Query: 1719 PLDIDECGEIPAI---CANG-----ICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
             ++++E  E P +   C  G      C +      C C  G+   S  ++CEDV+EC + 
Sbjct: 164  IIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG 223

Query: 1771 ESPCQQNADCINIPGSYRCK----CTRGYKLSPGGACVGRNECRE-IPNVCSHGDCMDTE 1825
               C+    CIN  GS+RC+    C  GY+L+   +C   +EC   I N      C +T 
Sbjct: 224  SHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 1826 GSYMCL----CHRGFQASADQTLCMDIDEC--DRQPCGNG-TCKNIIGSYNCL-----CF 1873
            GS+ C     C  GF   A    C+DI+EC     PC  G TC N  GSY C      C 
Sbjct: 284  GSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCG 342

Query: 1874 PGFVVTHNGD-CVDFDECTTLVGQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
             G+ +   G  CVD DEC     + C  GH C+N+ GSF C C+ G+      + CVD N
Sbjct: 343  RGYHLNEEGTRCVDVDECAP-PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989
            EC    G      C+N  GS+ C C  GF++  D   C DI+ECS  P       C N  
Sbjct: 402  ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVY 458

Query: 1990 GSFQCLCPPGFVLSD-NGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEG 2048
            GS+QC C  G+ LSD +G  C D             +C++P   +    RC     PG  
Sbjct: 459  GSYQCYCRRGYQLSDVDGVTCED-----------IDECALPTGGHICSYRCI--NIPG-- 503

Query: 2049 WGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCT-NGVCVNTDGSF 2107
                C  CP  G      L P G           +D++EC      C+ N  C N  G F
Sbjct: 504  -SFQCS-CPSSG----YRLAPNGRNC--------QDIDECVTGIHNCSINETCFNIQGGF 549

Query: 2108 RC---ECPFGY 2115
            RC   ECP  Y
Sbjct: 550  RCLAFECPENY 560



 Score =  176 bits (447), Expect = 2e-43
 Identities = 124/404 (30%), Positives = 177/404 (43%), Gaps = 60/404 (14%)

Query: 2224 ECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGR-CVNTAGSFRCDCDEG 2282
            +C++      C C  G + L   G  C D NEC      C  G  C+NT GSFRC  D  
Sbjct: 189  QCRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSS 247

Query: 2283 FQPSPTLTE---CHDIRQGPCFAEVLQTM----CRSLSSSSEAVTRAECCCGGGRGWGPR 2335
                  LTE   C DI +  C + +   +    C++   S     + +C  G  +     
Sbjct: 248  CGTGYELTEDNSCKDIDE--CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN 305

Query: 2336 CELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGE-CINSLGSFRC-----H 2389
            C                          D++EC  ++  C  G  CIN+ GS+ C     +
Sbjct: 306  CI-------------------------DINECLSISAPCPIGHTCINTEGSYTCQKNVPN 340

Query: 2390 CQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRGYLLEEDGRTCKDL 2447
            C  GY  +   T C+D+DEC+   +PC     C N+ GSF C C  GY  +   R C D+
Sbjct: 341  CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400

Query: 2448 DECTSRQHN-CQFLCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHN 2504
            +EC       C   C NT+G++ C C  GF  +   ++C D +ECS+ P        C N
Sbjct: 401  NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP----CSQECAN 456

Query: 2505 TPGSFRCECHQGFTLVS-SGHGCEDVNEC---DGPHRCQHGCQNQLGGYRCSCPQ-GFTQ 2559
              GS++C C +G+ L    G  CED++EC    G H C + C N  G ++CSCP  G+  
Sbjct: 457  VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRL 516

Query: 2560 HSQWAQCVDENECALSPPTCG-SASCRNTLGGFRCV---CPSGF 2599
                  C D +EC      C  + +C N  GGFRC+   CP  +
Sbjct: 517  APNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score =  173 bits (438), Expect = 2e-42
 Identities = 127/382 (33%), Positives = 177/382 (46%), Gaps = 51/382 (13%)

Query: 451 DECTSS-PCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNT 508
           D C    PC    C +      C C+ G+Q      +C DV+ECI     C LG  C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 509 EGSFQC----VCNAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSC----LCK 558
            GSF+C     C  G+EL+ D  +C D +EC +       + +C N  GSF C     CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 559 PGFLLAPGGHYCMDIDEC-QTPGICVNGH-CTNTEGSFRCQ-----CLGGLAVGTDGRVC 611
            GF+    G+ C+DI+EC      C  GH C NTEGS+ CQ     C  G  +  +G  C
Sbjct: 296 SGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354

Query: 612 VDTHVRSTCYGAIEKGSCARPFPGTVTKSEC-----------CCANPDHGFGEPCQLCPA 660
           VD    +       KG      PG+  + EC            C + +     P +LC  
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSF-RCECKTGYYFDGISRMCVDVNECQRYPGRLCGH 413

Query: 661 K---DSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYE 714
           K       +   CS G  ++ DGR   DINEC+  P    +  C N+ GSY+C C  GY+
Sbjct: 414 KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVYGSYQCYCRRGYQ 470

Query: 715 -AGASGKDCTDVDECAL--NSLLCDNGWCQNSPGSYSCSCP-PGFHFWQDTEICKDVDEC 770
            +   G  C D+DECAL     +C    C N PGS+ CSCP  G+    +   C+D+DEC
Sbjct: 471 LSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 771 LS---SPCVSGVCRNLAGSYTC 789
           ++   +  ++  C N+ G + C
Sbjct: 530 VTGIHNCSINETCFNIQGGFRC 551



 Score =  166 bits (421), Expect = 2e-40
 Identities = 144/506 (28%), Positives = 192/506 (37%), Gaps = 124/506 (24%)

Query: 2022 EAGKCSVPKAFNTTKT--------RCCCSKRPGEGWGDPCELCPQEG---SAAFQELC-- 2068
            E  +C+ P   N +           CC   R  +  G  CE     G      F+  C  
Sbjct: 87   EQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVK 146

Query: 2069 --PFGHGAVPGPDDSRE--DVNECAENPGV---CTNG-----VCVNTDGSFRCECPFGYS 2116
                G   V G  ++ +  +V E  E+P +   C  G      C +T     C C  GY 
Sbjct: 147  SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQ 206

Query: 2117 LDFTGINCVDTDECSVG-HPCGQG-TCTNVIGGFEC----ACADGFEPGLMMTCEDIDEC 2170
            L   G++C D +EC  G H C  G +C N +G F C    +C  G+E     +C+DIDEC
Sbjct: 207  LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDEC 266

Query: 2171 S------LNPLLC-----AFRCH------------------------------------- 2182
                   L   +C     +FRC                                      
Sbjct: 267  ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326

Query: 2183 NTEGSYLC-----TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCP 2237
            NTEGSY C      C  GY L E+G  C DVDECA   + C  +G  C N  G+F C C 
Sbjct: 327  NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECK 385

Query: 2238 PGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
             G     G    C D NEC   P      +C NT GS+ C C  GF+ S     C DI +
Sbjct: 386  TGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGY 2357
              C +      C ++  S       +C C  G       +L  + G +            
Sbjct: 445  --CSSSPCSQECANVYGS------YQCYCRRG------YQLSDVDGVTC----------- 479

Query: 2358 TAEGRDVDECRML--AHLCAHGECINSLGSFRCHC-QAGYTPDATATTCLDMDECSQVPK 2414
                 D+DEC +    H+C++  CIN  GSF+C C  +GY        C D+DEC     
Sbjct: 480  ----EDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 2415 PCTF--LCKNTKGSFLC---SCPRGY 2435
             C+    C N +G F C    CP  Y
Sbjct: 535  NCSINETCFNIQGGFRCLAFECPENY 560



 Score =  162 bits (410), Expect = 4e-39
 Identities = 113/377 (29%), Positives = 162/377 (42%), Gaps = 59/377 (15%)

Query: 2352 PHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS---------------FRCHC-QAGYT 2395
            PHG   + E   V  C    H C  G    + G                FR  C ++  T
Sbjct: 94   PHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150

Query: 2396 PDATATTCLDMDECSQVPK---------------PCTFLCKNTKGSFLCSCPRGYLLEED 2440
             D       + D+  +V +               PC   C++T    +CSC  GY L  D
Sbjct: 151  GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2441 GRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR----CPPGF-TQHHQACFDNDECSAQP 2493
            G +C+D++EC +  H+C+    C+NTVG+F C+    C  G+      +C D DEC +  
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270

Query: 2494 GPCGAHGHCHNTPGSFRC----ECHQGFTLVSSGHGCEDVNEC---DGPHRCQHGCQNQL 2546
              C     C NT GSFRC    +C  GF   + G+ C D+NEC     P    H C N  
Sbjct: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTE 329

Query: 2547 GGYRC-----SCPQGFTQHSQWAQCVDENECALSPPTCGSA-SCRNTLGGFRCVCPSGFD 2600
            G Y C     +C +G+  + +  +CVD +ECA     CG    C N+ G FRC C +G+ 
Sbjct: 330  GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 2601 FDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
            FD     C +V+EC    G  C + C NT G +LC C  G+  +  G     +       
Sbjct: 390  FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC---S 446

Query: 2660 DTPDKEELLSSEACYEC 2676
             +P  +E  +    Y+C
Sbjct: 447  SSPCSQECANVYGSYQC 463



 Score =  160 bits (405), Expect = 2e-38
 Identities = 172/631 (27%), Positives = 242/631 (38%), Gaps = 132/631 (20%)

Query: 479  QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-----VDHN 533
            +A P+R+  + +   ++ GGL  L   V+ +   +  C  G  ++   K+C      +  
Sbjct: 3    RAAPSRRVPLPL---LLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESK 59

Query: 534  ECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGS 593
            EC    M     C ++     C        A G     + D C TP    +G   + E +
Sbjct: 60   ECR---MVQEQCCHSQLEELHC--------ATGISLANEQDRCATP----HGDNASLEAT 104

Query: 594  F--RCQ--CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARP----------------F 633
            F  RC   CL G A    G+ C  + +     G + +  C +                  
Sbjct: 105  FVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKI 164

Query: 634  PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDP 690
                 + E    N     G PC+        E    C  G  + +DG    D+NEC    
Sbjct: 165  IEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224

Query: 691  EVCANGV-CENLRGSYRCV----CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSP 744
              C  G  C N  GS+RC     C  GYE       C D+DEC      C   + CQN+ 
Sbjct: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 745  GSYSC----SCPPGFHFWQDT-EICKDVDECLS--SPCVSG-VCRNLAGSYTCK-----C 791
            GS+ C     C  GF   QD    C D++ECLS  +PC  G  C N  GSYTC+     C
Sbjct: 284  GSFRCRPKLQCKSGFI--QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341

Query: 792  GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEI 851
            G G  L+  GT C+D  +           C    +       C  + G+       RCE 
Sbjct: 342  GRGYHLNEEGTRCVDVDE-----------CAPPAEPCGKGHRCVNSPGSF------RCE- 383

Query: 852  DPACARGFARMTGVT--CDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909
               C  G+    G++  C DVNEC+ +PG     +C NT GS+ C C  G  L   GR C
Sbjct: 384  ---CKTGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439

Query: 910  VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969
             D+           +EC            C      V+G             +   C RG
Sbjct: 440  EDI-----------NECS--------SSPCSQECANVYG------------SYQCYCRRG 468

Query: 970  LGFASRDFLSGRPFYKDVNECKVFPG--LCTHGTCRNTVGSFHCAC-AGGFALDAQERNC 1026
               +  D ++     +D++EC +  G  +C++  C N  GSF C+C + G+ L    RNC
Sbjct: 469  YQLSDVDGVT----CEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC 523

Query: 1027 TDIDECRISPDLCG-QGTCVNTPGSFECECF 1056
             DIDEC      C    TC N  G F C  F
Sbjct: 524  QDIDECVTGIHNCSINETCFNIQGGFRCLAF 554



 Score =  160 bits (405), Expect = 2e-38
 Identities = 144/480 (30%), Positives = 203/480 (42%), Gaps = 105/480 (21%)

Query: 1371 DLCDNG-----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN-LCAFG-SCENLP 1423
            D C  G     QC +      C C +G+    D  +C+DV+EC  G+  C  G SC N  
Sbjct: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 1424 GMFRC----ICNGGYELDRGGGNCTDINECADPV-NCI-NGVCINTPGSYLCSCPQDFEL 1477
            G FRC     C  GYEL     +C DI+EC   + NC+ + +C NT GS+ C      + 
Sbjct: 238  GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
                 G +    GNC     D  +  +S SA   +G T   C  + G             
Sbjct: 297  -----GFIQDALGNCI----DINEC-LSISAPCPIGHT---CINTEG------------- 330

Query: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCECPPGYHL 1596
            + T  + +   G G+  N       D+DEC      C +G  CVN+ GSF+CEC  GY+ 
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1597 SEHTRICEDIDECSTHSG-ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR 1655
               +R+C D++EC  + G +CG   C NTLG+Y C C   +     G +C D+ +     
Sbjct: 391  DGISRMCVDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINE----- 444

Query: 1656 HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILC--GNQAPGFLTD 1713
                                CS       + PC      +   YQ  C  G Q    L+D
Sbjct: 445  --------------------CS-------SSPCSQECANVYGSYQCYCRRGYQ----LSD 473

Query: 1714 IHTGKPLDIDECGEIPA---ICANGICINQIGSFRCECP-AGFNYNSILLACEDVDECGS 1769
            +      DIDEC  +P    IC+   CIN  GSF+C CP +G+        C+D+DEC +
Sbjct: 474  VDGVTCEDIDECA-LPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531

Query: 1770 RESPCQQNADCINIPGSYRC---KCTRGYKLS-------------PGGACVGRNECREIP 1813
                C  N  C NI G +RC   +C   Y+ S             P G+   + +CR +P
Sbjct: 532  GIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGS--SKEDCRVLP 589



 Score =  150 bits (379), Expect = 2e-35
 Identities = 110/335 (32%), Positives = 145/335 (43%), Gaps = 57/335 (17%)

Query: 409 IDICRHFTNLCL-NGRCLPTPSSYRC----ECNVGYTQDVRGECIDVDEC--TSSPCHHG 461
           ID C    + CL +  C  T  S+RC    +C  G+ QD  G CID++EC   S+PC  G
Sbjct: 263 IDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG 322

Query: 462 -DCVNIPGTYHCR-----CYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQC 514
             C+N  G+Y C+     C  G+        CVDVDEC      C  G RCVN+ GSF+C
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382

Query: 515 VCNAGFELSPDGKNCVDHNECA--TSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMD 572
            C  G+      + CVD NEC      +C    C N  GS+ C C  GF L+  G  C D
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSCED 441

Query: 573 IDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG-TDGRVCVDTHVRSTCYGAIEKGSCAR 631
           I+EC +     +  C N  GS++C C  G  +   DG  C D               CA 
Sbjct: 442 INECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDI------------DECAL 487

Query: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC-SSGLGITTDGR---DINECA 687
           P  G +    C                       FQ  C SSG  +  +GR   DI+EC 
Sbjct: 488 PTGGHICSYRC-----------------INIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530

Query: 688 LDPEVCA-NGVCENLRGSYRCV---CNLGYEAGAS 718
                C+ N  C N++G +RC+   C   Y   A+
Sbjct: 531 TGIHNCSINETCFNIQGGFRCLAFECPENYRRSAA 565



 Score =  147 bits (370), Expect = 2e-34
 Identities = 137/465 (29%), Positives = 181/465 (38%), Gaps = 77/465 (16%)

Query: 193 PEGCQHQLTGLVCTKALCCATVGRA---WGLPCELCPAQPHPCRRGF---------IPNI 240
           P G    L      +   C  +GRA    G  CE      + C + F           ++
Sbjct: 94  PHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDL 153

Query: 241 HTGACQDVD------ECQAVPGL---CQGGS-----CVNMVGSFHCRCPVGHRLSDSSAA 286
             G  Q+ D      E Q  P L   C+GG      C +      C C VG++L     +
Sbjct: 154 DVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVS 213

Query: 287 CEDYRA--GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
           CED         S   G  C   +     +R   C  G         EL       +  +
Sbjct: 214 CEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY--------ELTEDNSCKDIDE 265

Query: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
                        G+   L  F        LG  R  P      G      GN       
Sbjct: 266 C----------ESGIHNCLPDFICQNT---LGSFRCRPKLQCKSGFIQDALGNC------ 306

Query: 405 LNQTIDI--CRHFTNLCLNGR-CLPTPSSYRCECNV-----GYTQDVRG-ECIDVDECT- 454
               IDI  C   +  C  G  C+ T  SY C+ NV     GY  +  G  C+DVDEC  
Sbjct: 307 ----IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP 362

Query: 455 -SSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512
            + PC  G  CVN PG++ C C  G+      + CVDV+EC    G     +C NT GS+
Sbjct: 363 PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSY 422

Query: 513 QCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAP-GGHYCM 571
            C C+ GF LS DG++C D NEC++S    +  C N  GS+ C C+ G+ L+   G  C 
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 572 DIDECQTP--GICVNGHCTNTEGSFRCQC-LGGLAVGTDGRVCVD 613
           DIDEC  P  G   +  C N  GSF+C C   G  +  +GR C D
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525



 Score =  135 bits (340), Expect = 6e-31
 Identities = 107/357 (29%), Positives = 158/357 (44%), Gaps = 61/357 (17%)

Query: 244 ACQDVDECQAVPGLCQ-GGSCVNMVGSFHCR----CPVGHRLSDSSAACEDY---RAGA- 294
           +C+DV+EC      C+ G SC+N VGSF C+    C  G+ L++ ++ C+D     +G  
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271

Query: 295 -------CFSVLFGGRCAGDLAGHYTRRQC-----------CCDRGRCWAAG---PVPEL 333
                  C + L   RC   L       QC           C D   C +     P+   
Sbjct: 272 NCLPDFICQNTLGSFRCRPKL-------QCKSGFIQDALGNCIDINECLSISAPCPIGHT 324

Query: 334 CPPRGSNEFQQLCAQRLPLLP-GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS 392
           C    + E    C + +P    G+     G      +   PP  P      G   R + S
Sbjct: 325 CI---NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-----GKGHRCVNS 376

Query: 393 LGP-------GNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRG 445
            G        G    G + +   ++ C+ +       +C  T  SY C C+VG+   V G
Sbjct: 377 PGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDG 436

Query: 446 -ECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPT-RQACVDVDEC-IVSGGLCHL 502
             C D++EC+SSPC   +C N+ G+Y C C  G+Q +      C D+DEC + +GG    
Sbjct: 437 RSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS 495

Query: 503 GRCVNTEGSFQCVC-NAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSCL 556
            RC+N  GSFQC C ++G+ L+P+G+NC D +EC T      +N  C N  G F CL
Sbjct: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 93/365 (25%), Positives = 127/365 (34%), Gaps = 98/365 (26%)

Query: 85  ICRRACGEGFCSQPNLCTCADGTLAPSCG----VSRGSGCSVSCMNGGTCRGA--SCLCQ 138
           IC+   G   C +P L  C  G +  + G    ++     S  C  G TC     S  CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 139 KGYTGTVCGQPICDRGCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG 195
           K         P C RG H    G RC+  + CA       P  E   +   C    G   
Sbjct: 336 KNV-------PNCGRGYHLNEEGTRCVDVDECA-------PPAEPCGKGHRCVNSPGSFR 381

Query: 196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVP 255
           C+                                  C+ G+  +  +  C DV+ECQ  P
Sbjct: 382 CE----------------------------------CKTGYYFDGISRMCVDVNECQRYP 407

Query: 256 GLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR 315
           G   G  C N +GS+ C C VG RLS    +CED     C S      C+ + A  Y   
Sbjct: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INECSS----SPCSQECANVYGSY 461

Query: 316 QCCCDRGRCWA------AGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSN 369
           QC C RG   +         + E   P G +    +C+ R   +P            GS 
Sbjct: 462 QCYCRRGYQLSDVDGVTCEDIDECALPTGGH----ICSYRCINIP------------GSF 505

Query: 370 GMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCL--PT 427
               P    RL P+G + + I     G   I   ++N+T        N+    RCL    
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTG---IHNCSINETC------FNIQGGFRCLAFEC 556

Query: 428 PSSYR 432
           P +YR
Sbjct: 557 PENYR 561



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 105/423 (24%), Positives = 142/423 (33%), Gaps = 87/423 (20%)

Query: 86  CRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSV--SCMNGG-TCR-GASCLCQKGY 141
           C++ C +       +C+C  G    S GVS    C     C+ G  +CR G SC+   G 
Sbjct: 186 CKQQCRD--TGDEVVCSCFVGYQLLSDGVS----CEDVNECITGSHSCRLGESCINTVG- 238

Query: 142 TGTVCGQPICDRGCHNGGRCIGPNRCA----CVYGFMGPQCERDYRTGPCFGQVGPEGCQ 197
               C +   D  C  G      N C     C  G     C  D+    C   +G   C+
Sbjct: 239 -SFRCQR---DSSCGTGYELTEDNSCKDIDECESGIHN--CLPDFI---CQNTLGSFRCR 289

Query: 198 HQL---TGLVCTKALCCATVGRAWGL--PCEL------------CPAQPHPCRRGFIPNI 240
            +L   +G +      C  +     +  PC +            C      C RG+  N 
Sbjct: 290 PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 241 HTGACQDVDECQAVPGLC-QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF-SV 298
               C DVDEC      C +G  CVN  GSF C C  G+     S  C D      +   
Sbjct: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409

Query: 299 LFGGRCAGDLAGHYTRRQCCCDRG-RCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHP 357
           L G +C   L  +     C C  G R    G   E      S+   Q CA          
Sbjct: 410 LCGHKCENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECA---------- 455

Query: 358 GLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTN 417
                      N  G      R     SD  G+        +I    L     IC +   
Sbjct: 456 -----------NVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGGHICSY--- 496

Query: 418 LCLNGRCLPTPSSYRCEC-NVGYTQDVRG-ECIDVDECTSS--PCHHGD-CVNIPGTYHC 472
                RC+  P S++C C + GY     G  C D+DEC +    C   + C NI G + C
Sbjct: 497 -----RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551

Query: 473 RCY 475
             +
Sbjct: 552 LAF 554


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  251 bits (641), Expect = 7e-66
 Identities = 156/403 (38%), Positives = 208/403 (51%), Gaps = 51/403 (12%)

Query: 1030 DECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKN---CMDVDECARDPLLCR-GG 1085
            D CR     C Q  C +T     C CF GY+    L+ +   C DV+EC      CR G 
Sbjct: 178  DRCR-GGGPCKQ-QCRDTGDEVVCSCFVGYQ----LLSDGVSCEDVNECITGSHSCRLGE 231

Query: 1086 TCTNTDGSYKCQ----CPPGHELTAKGTACEDIDECSLSDGLC-PHGQCVNVIGAFQC-- 1138
            +C NT GS++CQ    C  G+ELT +  +C+DIDEC      C P   C N +G+F+C  
Sbjct: 232  SCINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 1139 --SCHAGFQSTPDRQG-CVDINECRVQNGGCDVH--CINTEGSYRC-----SCGQGYSLM 1188
               C +GF    D  G C+DINEC   +  C +   CINTEGSY C     +CG+GY L 
Sbjct: 291  KLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLN 348

Query: 1189 PDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNP- 1246
             +G  C DVDEC      C +GH C N PG  RC C  G+      R CVDV+EC   P 
Sbjct: 349  EEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408

Query: 1247 HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC 1306
             +C H  CENT GS++C C +G+ +      C D++EC     +      C N+ GS+ C
Sbjct: 409  RLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQC 463

Query: 1307 RCLPGWV---GDGFECHDLDECV--SQEHRCSPRGDCLNVPGSYRCTCRQG---FAGDGF 1358
             C  G+     DG  C D+DEC   +  H CS R  C+N+PGS++C+C       A +G 
Sbjct: 464  YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGR 521

Query: 1359 FCEDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDHR 1400
             C+D DEC   +  C  N  C N  GG+RC   + F+  E++R
Sbjct: 522  NCQDIDECVTGIHNCSINETCFNIQGGFRC---LAFECPENYR 561



 Score =  222 bits (566), Expect = 4e-57
 Identities = 133/366 (36%), Positives = 177/366 (48%), Gaps = 65/366 (17%)

Query: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECE----CF 1056
            CR+T     C+C  G+ L +   +C D++EC      C  G +C+NT GSF C+    C 
Sbjct: 190  CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249

Query: 1057 PGYE------------------------------------------SGFM--LMKNCMDV 1072
             GYE                                          SGF+   + NC+D+
Sbjct: 250  TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDI 309

Query: 1073 DECARDPLLCR-GGTCTNTDGSYKCQ-----CPPGHELTAKGTACEDIDECSLSDGLCPH 1126
            +EC      C  G TC NT+GSY CQ     C  G+ L  +GT C D+DEC+     C  
Sbjct: 310  NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369

Query: 1127 G-QCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG-CDVHCINTEGSYRCSCGQG 1184
            G +CVN  G+F+C C  G+      + CVD+NEC+   G  C   C NT GSY CSC  G
Sbjct: 370  GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429

Query: 1185 YSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGF-MATPDMRTCVDVDECD 1243
            + L  DGR+C D++EC  +P  C Q  C N+ G ++C C  G+ ++  D  TC D+DEC 
Sbjct: 430  FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 1244 L--NPHICLHGDCENTKGSFVCHC-QLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNI 1300
            L    HIC +  C N  GSF C C   GY +      C D+DEC  G HNC  + +C NI
Sbjct: 487  LPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545

Query: 1301 PGSFSC 1306
             G F C
Sbjct: 546  QGGFRC 551



 Score =  216 bits (549), Expect = 3e-55
 Identities = 163/494 (32%), Positives = 216/494 (43%), Gaps = 93/494 (18%)

Query: 2111 CPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPG------LMMTC 2164
            C  G +    G +C  +    VG+ CGQ         F   C    E G      L  T 
Sbjct: 113  CLLGRAAQAQGQSCEYS--LMVGYQCGQV--------FRACCVKSQETGDLDVGGLQETD 162

Query: 2165 E--DIDECSLNPLL---------CAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECAD 2213
            +  +++E   +P L         C  +C +T    +C+C  GY L  DG  C DV+EC  
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT 222

Query: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG------- 2266
            G   C   G  C N +G+F C          G+G   T+DN C    D C +G       
Sbjct: 223  GSHSCRL-GESCINTVGSFRCQRDSSC----GTGYELTEDNSC-KDIDECESGIHNCLPD 276

Query: 2267 -RCVNTAGSFRC----DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
              C NT GSFRC     C  GF     L  C DI +           C S+S        
Sbjct: 277  FICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINE-----------CLSIS-------- 316

Query: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPH-GSGY--TAEGR---DVDECRMLAHLCA 2375
            A C  G               G+   +K  P+ G GY    EG    DVDEC   A  C 
Sbjct: 317  APCPIGH--------TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368

Query: 2376 HG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP-KPCTFLCKNTKGSFLCSCPR 2433
             G  C+NS GSFRC C+ GY  D  +  C+D++EC + P + C   C+NT GS+LCSC  
Sbjct: 369  KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH---QACFDNDECS 2490
            G+ L  DGR+C+D++EC+S    C   C N  G++ C C  G+         C D DEC+
Sbjct: 429  GFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 2491 AQPGPCGAHGHCHNTPGSFRCEC-HQGFTLVSSGHGCEDVNEC-DGPHRC--QHGCQNQL 2546
               G       C N PGSF+C C   G+ L  +G  C+D++EC  G H C     C N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 2547 GGYRC---SCPQGF 2557
            GG+RC    CP+ +
Sbjct: 547  GGFRCLAFECPENY 560



 Score =  214 bits (546), Expect = 7e-55
 Identities = 136/379 (35%), Positives = 186/379 (49%), Gaps = 34/379 (8%)

Query: 1160 RVQNGG-CDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPG 1217
            R + GG C   C +T     CSC  GY L+ DG +C DV+EC      C  G  C N  G
Sbjct: 179  RCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVG 238

Query: 1218 GHRCL----CYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVCH----CQLG 1268
              RC     C  G+  T D  +C D+DEC+   H CL    C+NT GSF C     C+ G
Sbjct: 239  SFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297

Query: 1269 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCR-----CLPGWV--GDGFECHD 1321
            + ++     C D++EC      C    +C+N  GS++C+     C  G+    +G  C D
Sbjct: 298  F-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD 356

Query: 1322 LDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF--FCEDRDECAENVDLCDNGQCL 1379
            +DEC      C     C+N PGS+RC C+ G+  DG    C D +EC          +C 
Sbjct: 357  VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE 416

Query: 1380 NAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYEL-DR 1438
            N  G Y C C +GF  + D R+C+D++EC+  + C+   C N+ G ++C C  GY+L D 
Sbjct: 417  NTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCS-QECANVYGSYQCYCRRGYQLSDV 474

Query: 1439 GGGNCTDINECADPV--NCINGVCINTPGSYLCSCPQD-FELNPSGVGCVD-----TRAG 1490
             G  C DI+ECA P   +  +  CIN PGS+ CSCP   + L P+G  C D     T   
Sbjct: 475  DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 1491 NCFL-ETHDRGDSGISCSA 1508
            NC + ET      G  C A
Sbjct: 535  NCSINETCFNIQGGFRCLA 553



 Score =  213 bits (543), Expect = 2e-54
 Identities = 141/380 (37%), Positives = 182/380 (47%), Gaps = 51/380 (13%)

Query: 2330 RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEG---RDVDECRMLAHLCAHGE-CINSLGS 2385
            RG GP  + C   G       C  G    ++G    DV+EC   +H C  GE CIN++GS
Sbjct: 181  RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 2386 FRCH----CQAGY--TPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLC----SCPR 2433
            FRC     C  GY  T D    +C D+DEC      C   F+C+NT GSF C     C  
Sbjct: 240  FRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR-----CPPGFTQHHQA--CF 2484
            G++ +  G  C D++EC S    C     C+NT G++TC+     C  G+  + +   C 
Sbjct: 297  GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG-PHR-CQHGC 2542
            D DEC+    PCG    C N+PGSFRCEC  G+        C DVNEC   P R C H C
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 2543 QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFD 2602
            +N LG Y CSC  GF        C D NEC+ SP  C S  C N  G ++C C  G+   
Sbjct: 416  ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGYQLS 472

Query: 2603 QALG-GCQEVDECAGRRGP--CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
               G  C+++DECA   G   CSY C N PG F C CP            SG   +P  +
Sbjct: 473  DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-----------SGYRLAPNGR 521

Query: 2660 DTPDKEELLSSEACYECKIN 2679
            +  D +E ++    + C IN
Sbjct: 522  NCQDIDECVT--GIHNCSIN 539



 Score =  197 bits (500), Expect = 2e-49
 Identities = 137/397 (34%), Positives = 186/397 (46%), Gaps = 51/397 (12%)

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943
            +C +T     C C  G  L + G  C DV           +EC +T     R+   C  I
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NEC-ITGSHSCRLGESC--I 234

Query: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHG-TC 1002
              V    C+           S C  G G+   +  S     KD++EC+     C     C
Sbjct: 235  NTVGSFRCQR---------DSSC--GTGYELTEDNS----CKDIDECESGIHNCLPDFIC 279

Query: 1003 RNTVGSFHCA----CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECEC-F 1056
            +NT+GSF C     C  GF  DA   NC DI+EC      C  G TC+NT GS+ C+   
Sbjct: 280  QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1057 PGYESGFMLMKN---CMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE 1112
            P    G+ L +    C+DVDECA     C +G  C N+ GS++C+C  G+        C 
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 1113 DIDECSLSDG-LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCI 1171
            D++EC    G LC H +C N +G++ CSC  GF+ + D + C DINEC   +  C   C 
Sbjct: 399  DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECA 455

Query: 1172 NTEGSYRCSCGQGYSLMP-DGRACADVDEC--EENPRVCDQGHCTNMPGGHRCLC-YDGF 1227
            N  GSY+C C +GY L   DG  C D+DEC       +C    C N+PG  +C C   G+
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGY 514

Query: 1228 MATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVC 1263
               P+ R C D+DEC    H C ++  C N +G F C
Sbjct: 515  RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  187 bits (476), Expect = 1e-46
 Identities = 158/491 (32%), Positives = 211/491 (42%), Gaps = 84/491 (17%)

Query: 1672 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCG---------NQAPGFLTDI----HTGK 1718
            K CC    +G+A     ++C   +   YQ  CG         +Q  G L D+     T K
Sbjct: 107  KRCCHCCLLGRAAQAQGQSCEYSLMVGYQ--CGQVFRACCVKSQETGDL-DVGGLQETDK 163

Query: 1719 PLDIDECGEIPAI---CANG-----ICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
             ++++E  E P +   C  G      C +      C C  G+   S  ++CEDV+EC + 
Sbjct: 164  IIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG 223

Query: 1771 ESPCQQNADCINIPGSYRCK----CTRGYKLSPGGACVGRNECRE-IPNVCSHGDCMDTE 1825
               C+    CIN  GS+RC+    C  GY+L+   +C   +EC   I N      C +T 
Sbjct: 224  SHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 1826 GSYMCL----CHRGFQASADQTLCMDIDEC--DRQPCGNG-TCKNIIGSYNCL-----CF 1873
            GS+ C     C  GF   A    C+DI+EC     PC  G TC N  GSY C      C 
Sbjct: 284  GSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCG 342

Query: 1874 PGFVVTHNGD-CVDFDECTTLVGQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
             G+ +   G  CVD DEC     + C  GH C+N+ GSF C C+ G+      + CVD N
Sbjct: 343  RGYHLNEEGTRCVDVDECAP-PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989
            EC    G      C+N  GS+ C C  GF++  D   C DI+ECS  P       C N  
Sbjct: 402  ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVY 458

Query: 1990 GSFQCLCPPGFVLSD-NGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEG 2048
            GS+QC C  G+ LSD +G  C D             +C++P   +    RC     PG  
Sbjct: 459  GSYQCYCRRGYQLSDVDGVTCED-----------IDECALPTGGHICSYRCI--NIPG-- 503

Query: 2049 WGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCT-NGVCVNTDGSF 2107
                C  CP  G      L P G           +D++EC      C+ N  C N  G F
Sbjct: 504  -SFQCS-CPSSG----YRLAPNGRNC--------QDIDECVTGIHNCSINETCFNIQGGF 549

Query: 2108 RC---ECPFGY 2115
            RC   ECP  Y
Sbjct: 550  RCLAFECPENY 560



 Score =  176 bits (447), Expect = 2e-43
 Identities = 124/404 (30%), Positives = 177/404 (43%), Gaps = 60/404 (14%)

Query: 2224 ECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGR-CVNTAGSFRCDCDEG 2282
            +C++      C C  G + L   G  C D NEC      C  G  C+NT GSFRC  D  
Sbjct: 189  QCRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSS 247

Query: 2283 FQPSPTLTE---CHDIRQGPCFAEVLQTM----CRSLSSSSEAVTRAECCCGGGRGWGPR 2335
                  LTE   C DI +  C + +   +    C++   S     + +C  G  +     
Sbjct: 248  CGTGYELTEDNSCKDIDE--CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN 305

Query: 2336 CELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGE-CINSLGSFRC-----H 2389
            C                          D++EC  ++  C  G  CIN+ GS+ C     +
Sbjct: 306  CI-------------------------DINECLSISAPCPIGHTCINTEGSYTCQKNVPN 340

Query: 2390 CQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRGYLLEEDGRTCKDL 2447
            C  GY  +   T C+D+DEC+   +PC     C N+ GSF C C  GY  +   R C D+
Sbjct: 341  CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400

Query: 2448 DECTSRQHN-CQFLCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHN 2504
            +EC       C   C NT+G++ C C  GF  +   ++C D +ECS+ P        C N
Sbjct: 401  NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP----CSQECAN 456

Query: 2505 TPGSFRCECHQGFTLVS-SGHGCEDVNEC---DGPHRCQHGCQNQLGGYRCSCPQ-GFTQ 2559
              GS++C C +G+ L    G  CED++EC    G H C + C N  G ++CSCP  G+  
Sbjct: 457  VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRL 516

Query: 2560 HSQWAQCVDENECALSPPTCG-SASCRNTLGGFRCV---CPSGF 2599
                  C D +EC      C  + +C N  GGFRC+   CP  +
Sbjct: 517  APNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score =  173 bits (438), Expect = 2e-42
 Identities = 127/382 (33%), Positives = 177/382 (46%), Gaps = 51/382 (13%)

Query: 451 DECTSS-PCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNT 508
           D C    PC    C +      C C+ G+Q      +C DV+ECI     C LG  C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 509 EGSFQC----VCNAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSC----LCK 558
            GSF+C     C  G+EL+ D  +C D +EC +       + +C N  GSF C     CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 559 PGFLLAPGGHYCMDIDEC-QTPGICVNGH-CTNTEGSFRCQ-----CLGGLAVGTDGRVC 611
            GF+    G+ C+DI+EC      C  GH C NTEGS+ CQ     C  G  +  +G  C
Sbjct: 296 SGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354

Query: 612 VDTHVRSTCYGAIEKGSCARPFPGTVTKSEC-----------CCANPDHGFGEPCQLCPA 660
           VD    +       KG      PG+  + EC            C + +     P +LC  
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSF-RCECKTGYYFDGISRMCVDVNECQRYPGRLCGH 413

Query: 661 K---DSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYE 714
           K       +   CS G  ++ DGR   DINEC+  P    +  C N+ GSY+C C  GY+
Sbjct: 414 KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVYGSYQCYCRRGYQ 470

Query: 715 -AGASGKDCTDVDECAL--NSLLCDNGWCQNSPGSYSCSCP-PGFHFWQDTEICKDVDEC 770
            +   G  C D+DECAL     +C    C N PGS+ CSCP  G+    +   C+D+DEC
Sbjct: 471 LSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 771 LS---SPCVSGVCRNLAGSYTC 789
           ++   +  ++  C N+ G + C
Sbjct: 530 VTGIHNCSINETCFNIQGGFRC 551



 Score =  166 bits (421), Expect = 2e-40
 Identities = 144/506 (28%), Positives = 192/506 (37%), Gaps = 124/506 (24%)

Query: 2022 EAGKCSVPKAFNTTKT--------RCCCSKRPGEGWGDPCELCPQEG---SAAFQELC-- 2068
            E  +C+ P   N +           CC   R  +  G  CE     G      F+  C  
Sbjct: 87   EQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVK 146

Query: 2069 --PFGHGAVPGPDDSRE--DVNECAENPGV---CTNG-----VCVNTDGSFRCECPFGYS 2116
                G   V G  ++ +  +V E  E+P +   C  G      C +T     C C  GY 
Sbjct: 147  SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQ 206

Query: 2117 LDFTGINCVDTDECSVG-HPCGQG-TCTNVIGGFEC----ACADGFEPGLMMTCEDIDEC 2170
            L   G++C D +EC  G H C  G +C N +G F C    +C  G+E     +C+DIDEC
Sbjct: 207  LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDEC 266

Query: 2171 S------LNPLLC-----AFRCH------------------------------------- 2182
                   L   +C     +FRC                                      
Sbjct: 267  ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326

Query: 2183 NTEGSYLC-----TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCP 2237
            NTEGSY C      C  GY L E+G  C DVDECA   + C  +G  C N  G+F C C 
Sbjct: 327  NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECK 385

Query: 2238 PGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
             G     G    C D NEC   P      +C NT GS+ C C  GF+ S     C DI +
Sbjct: 386  TGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGY 2357
              C +      C ++  S       +C C  G       +L  + G +            
Sbjct: 445  --CSSSPCSQECANVYGS------YQCYCRRG------YQLSDVDGVTC----------- 479

Query: 2358 TAEGRDVDECRML--AHLCAHGECINSLGSFRCHC-QAGYTPDATATTCLDMDECSQVPK 2414
                 D+DEC +    H+C++  CIN  GSF+C C  +GY        C D+DEC     
Sbjct: 480  ----EDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 2415 PCTF--LCKNTKGSFLC---SCPRGY 2435
             C+    C N +G F C    CP  Y
Sbjct: 535  NCSINETCFNIQGGFRCLAFECPENY 560



 Score =  162 bits (410), Expect = 4e-39
 Identities = 113/377 (29%), Positives = 162/377 (42%), Gaps = 59/377 (15%)

Query: 2352 PHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS---------------FRCHC-QAGYT 2395
            PHG   + E   V  C    H C  G    + G                FR  C ++  T
Sbjct: 94   PHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150

Query: 2396 PDATATTCLDMDECSQVPK---------------PCTFLCKNTKGSFLCSCPRGYLLEED 2440
             D       + D+  +V +               PC   C++T    +CSC  GY L  D
Sbjct: 151  GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2441 GRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR----CPPGF-TQHHQACFDNDECSAQP 2493
            G +C+D++EC +  H+C+    C+NTVG+F C+    C  G+      +C D DEC +  
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270

Query: 2494 GPCGAHGHCHNTPGSFRC----ECHQGFTLVSSGHGCEDVNEC---DGPHRCQHGCQNQL 2546
              C     C NT GSFRC    +C  GF   + G+ C D+NEC     P    H C N  
Sbjct: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTE 329

Query: 2547 GGYRC-----SCPQGFTQHSQWAQCVDENECALSPPTCGSA-SCRNTLGGFRCVCPSGFD 2600
            G Y C     +C +G+  + +  +CVD +ECA     CG    C N+ G FRC C +G+ 
Sbjct: 330  GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 2601 FDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
            FD     C +V+EC    G  C + C NT G +LC C  G+  +  G     +       
Sbjct: 390  FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC---S 446

Query: 2660 DTPDKEELLSSEACYEC 2676
             +P  +E  +    Y+C
Sbjct: 447  SSPCSQECANVYGSYQC 463



 Score =  160 bits (405), Expect = 2e-38
 Identities = 172/631 (27%), Positives = 242/631 (38%), Gaps = 132/631 (20%)

Query: 479  QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-----VDHN 533
            +A P+R+  + +   ++ GGL  L   V+ +   +  C  G  ++   K+C      +  
Sbjct: 3    RAAPSRRVPLPL---LLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESK 59

Query: 534  ECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGS 593
            EC    M     C ++     C        A G     + D C TP    +G   + E +
Sbjct: 60   ECR---MVQEQCCHSQLEELHC--------ATGISLANEQDRCATP----HGDNASLEAT 104

Query: 594  F--RCQ--CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARP----------------F 633
            F  RC   CL G A    G+ C  + +     G + +  C +                  
Sbjct: 105  FVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKI 164

Query: 634  PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDP 690
                 + E    N     G PC+        E    C  G  + +DG    D+NEC    
Sbjct: 165  IEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224

Query: 691  EVCANGV-CENLRGSYRCV----CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSP 744
              C  G  C N  GS+RC     C  GYE       C D+DEC      C   + CQN+ 
Sbjct: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 745  GSYSC----SCPPGFHFWQDT-EICKDVDECLS--SPCVSG-VCRNLAGSYTCK-----C 791
            GS+ C     C  GF   QD    C D++ECLS  +PC  G  C N  GSYTC+     C
Sbjct: 284  GSFRCRPKLQCKSGFI--QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341

Query: 792  GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEI 851
            G G  L+  GT C+D  +           C    +       C  + G+       RCE 
Sbjct: 342  GRGYHLNEEGTRCVDVDE-----------CAPPAEPCGKGHRCVNSPGSF------RCE- 383

Query: 852  DPACARGFARMTGVT--CDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909
               C  G+    G++  C DVNEC+ +PG     +C NT GS+ C C  G  L   GR C
Sbjct: 384  ---CKTGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439

Query: 910  VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969
             D+           +EC            C      V+G             +   C RG
Sbjct: 440  EDI-----------NECS--------SSPCSQECANVYG------------SYQCYCRRG 468

Query: 970  LGFASRDFLSGRPFYKDVNECKVFPG--LCTHGTCRNTVGSFHCAC-AGGFALDAQERNC 1026
               +  D ++     +D++EC +  G  +C++  C N  GSF C+C + G+ L    RNC
Sbjct: 469  YQLSDVDGVT----CEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC 523

Query: 1027 TDIDECRISPDLCG-QGTCVNTPGSFECECF 1056
             DIDEC      C    TC N  G F C  F
Sbjct: 524  QDIDECVTGIHNCSINETCFNIQGGFRCLAF 554



 Score =  159 bits (403), Expect = 3e-38
 Identities = 139/452 (30%), Positives = 194/452 (42%), Gaps = 90/452 (19%)

Query: 1371 DLCDNG-----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN-LCAFG-SCENLP 1423
            D C  G     QC +      C C +G+    D  +C+DV+EC  G+  C  G SC N  
Sbjct: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 1424 GMFRC----ICNGGYELDRGGGNCTDINECADPV-NCI-NGVCINTPGSYLCSCPQDFEL 1477
            G FRC     C  GYEL     +C DI+EC   + NC+ + +C NT GS+ C      + 
Sbjct: 238  GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
                 G +    GNC     D  +  +S SA   +G T   C  + G             
Sbjct: 297  -----GFIQDALGNCI----DINEC-LSISAPCPIGHT---CINTEG------------- 330

Query: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCECPPGYHL 1596
            + T  + +   G G+  N       D+DEC      C +G  CVN+ GSF+CEC  GY+ 
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1597 SEHTRICEDIDECSTHSG-ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR 1655
               +R+C D++EC  + G +CG   C NTLG+Y C C   +     G +C D+ +     
Sbjct: 391  DGISRMCVDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINE----- 444

Query: 1656 HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILC--GNQAPGFLTD 1713
                                CS       + PC      +   YQ  C  G Q    L+D
Sbjct: 445  --------------------CS-------SSPCSQECANVYGSYQCYCRRGYQ----LSD 473

Query: 1714 IHTGKPLDIDECGEIPA---ICANGICINQIGSFRCECP-AGFNYNSILLACEDVDECGS 1769
            +      DIDEC  +P    IC+   CIN  GSF+C CP +G+        C+D+DEC +
Sbjct: 474  VDGVTCEDIDECA-LPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531

Query: 1770 RESPCQQNADCINIPGSYRC---KCTRGYKLS 1798
                C  N  C NI G +RC   +C   Y+ S
Sbjct: 532  GIHNCSINETCFNIQGGFRCLAFECPENYRRS 563



 Score =  150 bits (379), Expect = 2e-35
 Identities = 110/335 (32%), Positives = 145/335 (43%), Gaps = 57/335 (17%)

Query: 409 IDICRHFTNLCL-NGRCLPTPSSYRC----ECNVGYTQDVRGECIDVDEC--TSSPCHHG 461
           ID C    + CL +  C  T  S+RC    +C  G+ QD  G CID++EC   S+PC  G
Sbjct: 263 IDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG 322

Query: 462 -DCVNIPGTYHCR-----CYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQC 514
             C+N  G+Y C+     C  G+        CVDVDEC      C  G RCVN+ GSF+C
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382

Query: 515 VCNAGFELSPDGKNCVDHNECA--TSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMD 572
            C  G+      + CVD NEC      +C    C N  GS+ C C  GF L+  G  C D
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSCED 441

Query: 573 IDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG-TDGRVCVDTHVRSTCYGAIEKGSCAR 631
           I+EC +     +  C N  GS++C C  G  +   DG  C D               CA 
Sbjct: 442 INECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDI------------DECAL 487

Query: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC-SSGLGITTDGR---DINECA 687
           P  G +    C                       FQ  C SSG  +  +GR   DI+EC 
Sbjct: 488 PTGGHICSYRC-----------------INIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530

Query: 688 LDPEVCA-NGVCENLRGSYRCV---CNLGYEAGAS 718
                C+ N  C N++G +RC+   C   Y   A+
Sbjct: 531 TGIHNCSINETCFNIQGGFRCLAFECPENYRRSAA 565



 Score =  147 bits (370), Expect = 2e-34
 Identities = 137/465 (29%), Positives = 181/465 (38%), Gaps = 77/465 (16%)

Query: 193 PEGCQHQLTGLVCTKALCCATVGRA---WGLPCELCPAQPHPCRRGF---------IPNI 240
           P G    L      +   C  +GRA    G  CE      + C + F           ++
Sbjct: 94  PHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDL 153

Query: 241 HTGACQDVD------ECQAVPGL---CQGGS-----CVNMVGSFHCRCPVGHRLSDSSAA 286
             G  Q+ D      E Q  P L   C+GG      C +      C C VG++L     +
Sbjct: 154 DVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVS 213

Query: 287 CEDYRA--GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
           CED         S   G  C   +     +R   C  G         EL       +  +
Sbjct: 214 CEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY--------ELTEDNSCKDIDE 265

Query: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
                        G+   L  F        LG  R  P      G      GN       
Sbjct: 266 C----------ESGIHNCLPDFICQNT---LGSFRCRPKLQCKSGFIQDALGNC------ 306

Query: 405 LNQTIDI--CRHFTNLCLNGR-CLPTPSSYRCECNV-----GYTQDVRG-ECIDVDECT- 454
               IDI  C   +  C  G  C+ T  SY C+ NV     GY  +  G  C+DVDEC  
Sbjct: 307 ----IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP 362

Query: 455 -SSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512
            + PC  G  CVN PG++ C C  G+      + CVDV+EC    G     +C NT GS+
Sbjct: 363 PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSY 422

Query: 513 QCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAP-GGHYCM 571
            C C+ GF LS DG++C D NEC++S    +  C N  GS+ C C+ G+ L+   G  C 
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 572 DIDECQTP--GICVNGHCTNTEGSFRCQC-LGGLAVGTDGRVCVD 613
           DIDEC  P  G   +  C N  GSF+C C   G  +  +GR C D
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525



 Score =  135 bits (340), Expect = 6e-31
 Identities = 107/357 (29%), Positives = 158/357 (44%), Gaps = 61/357 (17%)

Query: 244 ACQDVDECQAVPGLCQ-GGSCVNMVGSFHCR----CPVGHRLSDSSAACEDY---RAGA- 294
           +C+DV+EC      C+ G SC+N VGSF C+    C  G+ L++ ++ C+D     +G  
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271

Query: 295 -------CFSVLFGGRCAGDLAGHYTRRQC-----------CCDRGRCWAAG---PVPEL 333
                  C + L   RC   L       QC           C D   C +     P+   
Sbjct: 272 NCLPDFICQNTLGSFRCRPKL-------QCKSGFIQDALGNCIDINECLSISAPCPIGHT 324

Query: 334 CPPRGSNEFQQLCAQRLPLLP-GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS 392
           C    + E    C + +P    G+     G      +   PP  P      G   R + S
Sbjct: 325 CI---NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-----GKGHRCVNS 376

Query: 393 LGP-------GNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRG 445
            G        G    G + +   ++ C+ +       +C  T  SY C C+VG+   V G
Sbjct: 377 PGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDG 436

Query: 446 -ECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPT-RQACVDVDEC-IVSGGLCHL 502
             C D++EC+SSPC   +C N+ G+Y C C  G+Q +      C D+DEC + +GG    
Sbjct: 437 RSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS 495

Query: 503 GRCVNTEGSFQCVC-NAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSCL 556
            RC+N  GSFQC C ++G+ L+P+G+NC D +EC T      +N  C N  G F CL
Sbjct: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 93/365 (25%), Positives = 127/365 (34%), Gaps = 98/365 (26%)

Query: 85  ICRRACGEGFCSQPNLCTCADGTLAPSCG----VSRGSGCSVSCMNGGTCRGA--SCLCQ 138
           IC+   G   C +P L  C  G +  + G    ++     S  C  G TC     S  CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 139 KGYTGTVCGQPICDRGCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG 195
           K         P C RG H    G RC+  + CA       P  E   +   C    G   
Sbjct: 336 KNV-------PNCGRGYHLNEEGTRCVDVDECA-------PPAEPCGKGHRCVNSPGSFR 381

Query: 196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVP 255
           C+                                  C+ G+  +  +  C DV+ECQ  P
Sbjct: 382 CE----------------------------------CKTGYYFDGISRMCVDVNECQRYP 407

Query: 256 GLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR 315
           G   G  C N +GS+ C C VG RLS    +CED     C S      C+ + A  Y   
Sbjct: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INECSS----SPCSQECANVYGSY 461

Query: 316 QCCCDRGRCWA------AGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSN 369
           QC C RG   +         + E   P G +    +C+ R   +P            GS 
Sbjct: 462 QCYCRRGYQLSDVDGVTCEDIDECALPTGGH----ICSYRCINIP------------GSF 505

Query: 370 GMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCL--PT 427
               P    RL P+G + + I     G   I   ++N+T        N+    RCL    
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTG---IHNCSINETC------FNIQGGFRCLAFEC 556

Query: 428 PSSYR 432
           P +YR
Sbjct: 557 PENYR 561



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 105/423 (24%), Positives = 142/423 (33%), Gaps = 87/423 (20%)

Query: 86  CRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSV--SCMNGG-TCR-GASCLCQKGY 141
           C++ C +       +C+C  G    S GVS    C     C+ G  +CR G SC+   G 
Sbjct: 186 CKQQCRD--TGDEVVCSCFVGYQLLSDGVS----CEDVNECITGSHSCRLGESCINTVG- 238

Query: 142 TGTVCGQPICDRGCHNGGRCIGPNRCA----CVYGFMGPQCERDYRTGPCFGQVGPEGCQ 197
               C +   D  C  G      N C     C  G     C  D+    C   +G   C+
Sbjct: 239 -SFRCQR---DSSCGTGYELTEDNSCKDIDECESGIHN--CLPDFI---CQNTLGSFRCR 289

Query: 198 HQL---TGLVCTKALCCATVGRAWGL--PCEL------------CPAQPHPCRRGFIPNI 240
            +L   +G +      C  +     +  PC +            C      C RG+  N 
Sbjct: 290 PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 241 HTGACQDVDECQAVPGLC-QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF-SV 298
               C DVDEC      C +G  CVN  GSF C C  G+     S  C D      +   
Sbjct: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409

Query: 299 LFGGRCAGDLAGHYTRRQCCCDRG-RCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHP 357
           L G +C   L  +     C C  G R    G   E      S+   Q CA          
Sbjct: 410 LCGHKCENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECA---------- 455

Query: 358 GLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTN 417
                      N  G      R     SD  G+        +I    L     IC +   
Sbjct: 456 -----------NVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGGHICSY--- 496

Query: 418 LCLNGRCLPTPSSYRCEC-NVGYTQDVRG-ECIDVDECTSS--PCHHGD-CVNIPGTYHC 472
                RC+  P S++C C + GY     G  C D+DEC +    C   + C NI G + C
Sbjct: 497 -----RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551

Query: 473 RCY 475
             +
Sbjct: 552 LAF 554


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  251 bits (641), Expect = 7e-66
 Identities = 156/403 (38%), Positives = 208/403 (51%), Gaps = 51/403 (12%)

Query: 1030 DECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKN---CMDVDECARDPLLCR-GG 1085
            D CR     C Q  C +T     C CF GY+    L+ +   C DV+EC      CR G 
Sbjct: 178  DRCR-GGGPCKQ-QCRDTGDEVVCSCFVGYQ----LLSDGVSCEDVNECITGSHSCRLGE 231

Query: 1086 TCTNTDGSYKCQ----CPPGHELTAKGTACEDIDECSLSDGLC-PHGQCVNVIGAFQC-- 1138
            +C NT GS++CQ    C  G+ELT +  +C+DIDEC      C P   C N +G+F+C  
Sbjct: 232  SCINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 1139 --SCHAGFQSTPDRQG-CVDINECRVQNGGCDVH--CINTEGSYRC-----SCGQGYSLM 1188
               C +GF    D  G C+DINEC   +  C +   CINTEGSY C     +CG+GY L 
Sbjct: 291  KLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLN 348

Query: 1189 PDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNP- 1246
             +G  C DVDEC      C +GH C N PG  RC C  G+      R CVDV+EC   P 
Sbjct: 349  EEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPG 408

Query: 1247 HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC 1306
             +C H  CENT GS++C C +G+ +      C D++EC     +      C N+ GS+ C
Sbjct: 409  RLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECS----SSPCSQECANVYGSYQC 463

Query: 1307 RCLPGWV---GDGFECHDLDECV--SQEHRCSPRGDCLNVPGSYRCTCRQG---FAGDGF 1358
             C  G+     DG  C D+DEC   +  H CS R  C+N+PGS++C+C       A +G 
Sbjct: 464  YCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPSSGYRLAPNGR 521

Query: 1359 FCEDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDHR 1400
             C+D DEC   +  C  N  C N  GG+RC   + F+  E++R
Sbjct: 522  NCQDIDECVTGIHNCSINETCFNIQGGFRC---LAFECPENYR 561



 Score =  222 bits (566), Expect = 4e-57
 Identities = 133/366 (36%), Positives = 177/366 (48%), Gaps = 65/366 (17%)

Query: 1002 CRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECE----CF 1056
            CR+T     C+C  G+ L +   +C D++EC      C  G +C+NT GSF C+    C 
Sbjct: 190  CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249

Query: 1057 PGYE------------------------------------------SGFM--LMKNCMDV 1072
             GYE                                          SGF+   + NC+D+
Sbjct: 250  TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDI 309

Query: 1073 DECARDPLLCR-GGTCTNTDGSYKCQ-----CPPGHELTAKGTACEDIDECSLSDGLCPH 1126
            +EC      C  G TC NT+GSY CQ     C  G+ L  +GT C D+DEC+     C  
Sbjct: 310  NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGK 369

Query: 1127 G-QCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG-CDVHCINTEGSYRCSCGQG 1184
            G +CVN  G+F+C C  G+      + CVD+NEC+   G  C   C NT GSY CSC  G
Sbjct: 370  GHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVG 429

Query: 1185 YSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGF-MATPDMRTCVDVDECD 1243
            + L  DGR+C D++EC  +P  C Q  C N+ G ++C C  G+ ++  D  TC D+DEC 
Sbjct: 430  FRLSVDGRSCEDINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 1244 L--NPHICLHGDCENTKGSFVCHC-QLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNI 1300
            L    HIC +  C N  GSF C C   GY +      C D+DEC  G HNC  + +C NI
Sbjct: 487  LPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545

Query: 1301 PGSFSC 1306
             G F C
Sbjct: 546  QGGFRC 551



 Score =  216 bits (550), Expect = 3e-55
 Identities = 164/502 (32%), Positives = 219/502 (43%), Gaps = 93/502 (18%)

Query: 2111 CPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPG------LMMTC 2164
            C  G +    G +C  +    VG+ CGQ         F   C    E G      L  T 
Sbjct: 113  CLLGRAAQAQGQSCEYS--LMVGYQCGQV--------FRACCVKSQETGDLDVGGLQETD 162

Query: 2165 E--DIDECSLNPLL---------CAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECAD 2213
            +  +++E   +P L         C  +C +T    +C+C  GY L  DG  C DV+EC  
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT 222

Query: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG------- 2266
            G   C   G  C N +G+F C          G+G   T+DN C    D C +G       
Sbjct: 223  GSHSCRL-GESCINTVGSFRCQRDSSC----GTGYELTEDNSC-KDIDECESGIHNCLPD 276

Query: 2267 -RCVNTAGSFRC----DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
              C NT GSFRC     C  GF     L  C DI +           C S+S        
Sbjct: 277  FICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINE-----------CLSIS-------- 316

Query: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPH-GSGY--TAEGR---DVDECRMLAHLCA 2375
            A C  G               G+   +K  P+ G GY    EG    DVDEC   A  C 
Sbjct: 317  APCPIGH--------TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368

Query: 2376 HG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP-KPCTFLCKNTKGSFLCSCPR 2433
             G  C+NS GSFRC C+ GY  D  +  C+D++EC + P + C   C+NT GS+LCSC  
Sbjct: 369  KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH---QACFDNDECS 2490
            G+ L  DGR+C+D++EC+S    C   C N  G++ C C  G+         C D DEC+
Sbjct: 429  GFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 2491 AQPGPCGAHGHCHNTPGSFRCEC-HQGFTLVSSGHGCEDVNEC-DGPHRC--QHGCQNQL 2546
               G       C N PGSF+C C   G+ L  +G  C+D++EC  G H C     C N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 2547 GGYRC---SCPQGFTQHSQWAQ 2565
            GG+RC    CP+ + + +   Q
Sbjct: 547  GGFRCLAFECPENYRRSAATLQ 568



 Score =  214 bits (546), Expect = 7e-55
 Identities = 136/379 (35%), Positives = 186/379 (49%), Gaps = 34/379 (8%)

Query: 1160 RVQNGG-CDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPG 1217
            R + GG C   C +T     CSC  GY L+ DG +C DV+EC      C  G  C N  G
Sbjct: 179  RCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVG 238

Query: 1218 GHRCL----CYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVCH----CQLG 1268
              RC     C  G+  T D  +C D+DEC+   H CL    C+NT GSF C     C+ G
Sbjct: 239  SFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297

Query: 1269 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCR-----CLPGWV--GDGFECHD 1321
            + ++     C D++EC      C    +C+N  GS++C+     C  G+    +G  C D
Sbjct: 298  F-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD 356

Query: 1322 LDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF--FCEDRDECAENVDLCDNGQCL 1379
            +DEC      C     C+N PGS+RC C+ G+  DG    C D +EC          +C 
Sbjct: 357  VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE 416

Query: 1380 NAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYEL-DR 1438
            N  G Y C C +GF  + D R+C+D++EC+  + C+   C N+ G ++C C  GY+L D 
Sbjct: 417  NTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCS-QECANVYGSYQCYCRRGYQLSDV 474

Query: 1439 GGGNCTDINECADPV--NCINGVCINTPGSYLCSCPQD-FELNPSGVGCVD-----TRAG 1490
             G  C DI+ECA P   +  +  CIN PGS+ CSCP   + L P+G  C D     T   
Sbjct: 475  DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 1491 NCFL-ETHDRGDSGISCSA 1508
            NC + ET      G  C A
Sbjct: 535  NCSINETCFNIQGGFRCLA 553



 Score =  213 bits (543), Expect = 2e-54
 Identities = 141/380 (37%), Positives = 182/380 (47%), Gaps = 51/380 (13%)

Query: 2330 RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEG---RDVDECRMLAHLCAHGE-CINSLGS 2385
            RG GP  + C   G       C  G    ++G    DV+EC   +H C  GE CIN++GS
Sbjct: 181  RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 2386 FRCH----CQAGY--TPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLC----SCPR 2433
            FRC     C  GY  T D    +C D+DEC      C   F+C+NT GSF C     C  
Sbjct: 240  FRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR-----CPPGFTQHHQA--CF 2484
            G++ +  G  C D++EC S    C     C+NT G++TC+     C  G+  + +   C 
Sbjct: 297  GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG-PHR-CQHGC 2542
            D DEC+    PCG    C N+PGSFRCEC  G+        C DVNEC   P R C H C
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 2543 QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFD 2602
            +N LG Y CSC  GF        C D NEC+ SP  C S  C N  G ++C C  G+   
Sbjct: 416  ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGYQLS 472

Query: 2603 QALG-GCQEVDECAGRRGP--CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
               G  C+++DECA   G   CSY C N PG F C CP            SG   +P  +
Sbjct: 473  DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-----------SGYRLAPNGR 521

Query: 2660 DTPDKEELLSSEACYECKIN 2679
            +  D +E ++    + C IN
Sbjct: 522  NCQDIDECVT--GIHNCSIN 539



 Score =  197 bits (500), Expect = 2e-49
 Identities = 137/397 (34%), Positives = 186/397 (46%), Gaps = 51/397 (12%)

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943
            +C +T     C C  G  L + G  C DV           +EC +T     R+   C  I
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NEC-ITGSHSCRLGESC--I 234

Query: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHG-TC 1002
              V    C+           S C  G G+   +  S     KD++EC+     C     C
Sbjct: 235  NTVGSFRCQR---------DSSC--GTGYELTEDNS----CKDIDECESGIHNCLPDFIC 279

Query: 1003 RNTVGSFHCA----CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECEC-F 1056
            +NT+GSF C     C  GF  DA   NC DI+EC      C  G TC+NT GS+ C+   
Sbjct: 280  QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1057 PGYESGFMLMKN---CMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE 1112
            P    G+ L +    C+DVDECA     C +G  C N+ GS++C+C  G+        C 
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 1113 DIDECSLSDG-LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCI 1171
            D++EC    G LC H +C N +G++ CSC  GF+ + D + C DINEC   +  C   C 
Sbjct: 399  DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECA 455

Query: 1172 NTEGSYRCSCGQGYSLMP-DGRACADVDEC--EENPRVCDQGHCTNMPGGHRCLC-YDGF 1227
            N  GSY+C C +GY L   DG  C D+DEC       +C    C N+PG  +C C   G+
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGY 514

Query: 1228 MATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVC 1263
               P+ R C D+DEC    H C ++  C N +G F C
Sbjct: 515  RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551



 Score =  187 bits (476), Expect = 1e-46
 Identities = 158/491 (32%), Positives = 211/491 (42%), Gaps = 84/491 (17%)

Query: 1672 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCG---------NQAPGFLTDI----HTGK 1718
            K CC    +G+A     ++C   +   YQ  CG         +Q  G L D+     T K
Sbjct: 107  KRCCHCCLLGRAAQAQGQSCEYSLMVGYQ--CGQVFRACCVKSQETGDL-DVGGLQETDK 163

Query: 1719 PLDIDECGEIPAI---CANG-----ICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
             ++++E  E P +   C  G      C +      C C  G+   S  ++CEDV+EC + 
Sbjct: 164  IIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG 223

Query: 1771 ESPCQQNADCINIPGSYRCK----CTRGYKLSPGGACVGRNECRE-IPNVCSHGDCMDTE 1825
               C+    CIN  GS+RC+    C  GY+L+   +C   +EC   I N      C +T 
Sbjct: 224  SHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 1826 GSYMCL----CHRGFQASADQTLCMDIDEC--DRQPCGNG-TCKNIIGSYNCL-----CF 1873
            GS+ C     C  GF   A    C+DI+EC     PC  G TC N  GSY C      C 
Sbjct: 284  GSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCG 342

Query: 1874 PGFVVTHNGD-CVDFDECTTLVGQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
             G+ +   G  CVD DEC     + C  GH C+N+ GSF C C+ G+      + CVD N
Sbjct: 343  RGYHLNEEGTRCVDVDECAP-PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989
            EC    G      C+N  GS+ C C  GF++  D   C DI+ECS  P       C N  
Sbjct: 402  ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVY 458

Query: 1990 GSFQCLCPPGFVLSD-NGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEG 2048
            GS+QC C  G+ LSD +G  C D             +C++P   +    RC     PG  
Sbjct: 459  GSYQCYCRRGYQLSDVDGVTCED-----------IDECALPTGGHICSYRCI--NIPG-- 503

Query: 2049 WGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCT-NGVCVNTDGSF 2107
                C  CP  G      L P G           +D++EC      C+ N  C N  G F
Sbjct: 504  -SFQCS-CPSSG----YRLAPNGRNC--------QDIDECVTGIHNCSINETCFNIQGGF 549

Query: 2108 RC---ECPFGY 2115
            RC   ECP  Y
Sbjct: 550  RCLAFECPENY 560



 Score =  176 bits (447), Expect = 2e-43
 Identities = 124/404 (30%), Positives = 177/404 (43%), Gaps = 60/404 (14%)

Query: 2224 ECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGR-CVNTAGSFRCDCDEG 2282
            +C++      C C  G + L   G  C D NEC      C  G  C+NT GSFRC  D  
Sbjct: 189  QCRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSS 247

Query: 2283 FQPSPTLTE---CHDIRQGPCFAEVLQTM----CRSLSSSSEAVTRAECCCGGGRGWGPR 2335
                  LTE   C DI +  C + +   +    C++   S     + +C  G  +     
Sbjct: 248  CGTGYELTEDNSCKDIDE--CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN 305

Query: 2336 CELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGE-CINSLGSFRC-----H 2389
            C                          D++EC  ++  C  G  CIN+ GS+ C     +
Sbjct: 306  CI-------------------------DINECLSISAPCPIGHTCINTEGSYTCQKNVPN 340

Query: 2390 CQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRGYLLEEDGRTCKDL 2447
            C  GY  +   T C+D+DEC+   +PC     C N+ GSF C C  GY  +   R C D+
Sbjct: 341  CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400

Query: 2448 DECTSRQHN-CQFLCVNTVGAFTCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHN 2504
            +EC       C   C NT+G++ C C  GF  +   ++C D +ECS+ P        C N
Sbjct: 401  NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP----CSQECAN 456

Query: 2505 TPGSFRCECHQGFTLVS-SGHGCEDVNEC---DGPHRCQHGCQNQLGGYRCSCPQ-GFTQ 2559
              GS++C C +G+ L    G  CED++EC    G H C + C N  G ++CSCP  G+  
Sbjct: 457  VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRL 516

Query: 2560 HSQWAQCVDENECALSPPTCG-SASCRNTLGGFRCV---CPSGF 2599
                  C D +EC      C  + +C N  GGFRC+   CP  +
Sbjct: 517  APNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560



 Score =  173 bits (438), Expect = 2e-42
 Identities = 127/382 (33%), Positives = 177/382 (46%), Gaps = 51/382 (13%)

Query: 451 DECTSS-PCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNT 508
           D C    PC    C +      C C+ G+Q      +C DV+ECI     C LG  C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 509 EGSFQC----VCNAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSC----LCK 558
            GSF+C     C  G+EL+ D  +C D +EC +       + +C N  GSF C     CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 559 PGFLLAPGGHYCMDIDEC-QTPGICVNGH-CTNTEGSFRCQ-----CLGGLAVGTDGRVC 611
            GF+    G+ C+DI+EC      C  GH C NTEGS+ CQ     C  G  +  +G  C
Sbjct: 296 SGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354

Query: 612 VDTHVRSTCYGAIEKGSCARPFPGTVTKSEC-----------CCANPDHGFGEPCQLCPA 660
           VD    +       KG      PG+  + EC            C + +     P +LC  
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSF-RCECKTGYYFDGISRMCVDVNECQRYPGRLCGH 413

Query: 661 K---DSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYE 714
           K       +   CS G  ++ DGR   DINEC+  P    +  C N+ GSY+C C  GY+
Sbjct: 414 KCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVYGSYQCYCRRGYQ 470

Query: 715 -AGASGKDCTDVDECAL--NSLLCDNGWCQNSPGSYSCSCP-PGFHFWQDTEICKDVDEC 770
            +   G  C D+DECAL     +C    C N PGS+ CSCP  G+    +   C+D+DEC
Sbjct: 471 LSDVDGVTCEDIDECALPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 529

Query: 771 LS---SPCVSGVCRNLAGSYTC 789
           ++   +  ++  C N+ G + C
Sbjct: 530 VTGIHNCSINETCFNIQGGFRC 551



 Score =  172 bits (435), Expect = 5e-42
 Identities = 152/542 (28%), Positives = 205/542 (37%), Gaps = 130/542 (23%)

Query: 2022 EAGKCSVPKAFNTTKT--------RCCCSKRPGEGWGDPCELCPQEG---SAAFQELC-- 2068
            E  +C+ P   N +           CC   R  +  G  CE     G      F+  C  
Sbjct: 87   EQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVK 146

Query: 2069 --PFGHGAVPGPDDSRE--DVNECAENPGV---CTNG-----VCVNTDGSFRCECPFGYS 2116
                G   V G  ++ +  +V E  E+P +   C  G      C +T     C C  GY 
Sbjct: 147  SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQ 206

Query: 2117 LDFTGINCVDTDECSVG-HPCGQG-TCTNVIGGFEC----ACADGFEPGLMMTCEDIDEC 2170
            L   G++C D +EC  G H C  G +C N +G F C    +C  G+E     +C+DIDEC
Sbjct: 207  LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDEC 266

Query: 2171 S------LNPLLC-----AFRCH------------------------------------- 2182
                   L   +C     +FRC                                      
Sbjct: 267  ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326

Query: 2183 NTEGSYLC-----TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCP 2237
            NTEGSY C      C  GY L E+G  C DVDECA   + C  +G  C N  G+F C C 
Sbjct: 327  NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECK 385

Query: 2238 PGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
             G     G    C D NEC   P      +C NT GS+ C C  GF+ S     C DI +
Sbjct: 386  TGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGY 2357
              C +      C ++  S       +C C  G       +L  + G +            
Sbjct: 445  --CSSSPCSQECANVYGS------YQCYCRRG------YQLSDVDGVTC----------- 479

Query: 2358 TAEGRDVDECRML--AHLCAHGECINSLGSFRCHC-QAGYTPDATATTCLDMDECSQVPK 2414
                 D+DEC +    H+C++  CIN  GSF+C C  +GY        C D+DEC     
Sbjct: 480  ----EDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 2415 PCTF--LCKNTKGSFLC---SCPRGY------LLEEDGRTCKDLDECTSRQHNCQFLCVN 2463
             C+    C N +G F C    CP  Y      L +E   T + +  C      C F  V+
Sbjct: 535  NCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVH 594

Query: 2464 TV 2465
            T+
Sbjct: 595  TI 596



 Score =  162 bits (410), Expect = 4e-39
 Identities = 113/377 (29%), Positives = 162/377 (42%), Gaps = 59/377 (15%)

Query: 2352 PHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS---------------FRCHC-QAGYT 2395
            PHG   + E   V  C    H C  G    + G                FR  C ++  T
Sbjct: 94   PHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150

Query: 2396 PDATATTCLDMDECSQVPK---------------PCTFLCKNTKGSFLCSCPRGYLLEED 2440
             D       + D+  +V +               PC   C++T    +CSC  GY L  D
Sbjct: 151  GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2441 GRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR----CPPGF-TQHHQACFDNDECSAQP 2493
            G +C+D++EC +  H+C+    C+NTVG+F C+    C  G+      +C D DEC +  
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270

Query: 2494 GPCGAHGHCHNTPGSFRC----ECHQGFTLVSSGHGCEDVNEC---DGPHRCQHGCQNQL 2546
              C     C NT GSFRC    +C  GF   + G+ C D+NEC     P    H C N  
Sbjct: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTE 329

Query: 2547 GGYRC-----SCPQGFTQHSQWAQCVDENECALSPPTCGSA-SCRNTLGGFRCVCPSGFD 2600
            G Y C     +C +G+  + +  +CVD +ECA     CG    C N+ G FRC C +G+ 
Sbjct: 330  GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 2601 FDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
            FD     C +V+EC    G  C + C NT G +LC C  G+  +  G     +       
Sbjct: 390  FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC---S 446

Query: 2660 DTPDKEELLSSEACYEC 2676
             +P  +E  +    Y+C
Sbjct: 447  SSPCSQECANVYGSYQC 463



 Score =  161 bits (408), Expect = 7e-39
 Identities = 181/667 (27%), Positives = 253/667 (37%), Gaps = 139/667 (20%)

Query: 479  QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-----VDHN 533
            +A P+R+  + +   ++ GGL  L   V+ +   +  C  G  ++   K+C      +  
Sbjct: 3    RAAPSRRVPLPL---LLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESK 59

Query: 534  ECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGS 593
            EC    M     C ++     C        A G     + D C TP    +G   + E +
Sbjct: 60   ECR---MVQEQCCHSQLEELHC--------ATGISLANEQDRCATP----HGDNASLEAT 104

Query: 594  F--RCQ--CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARP----------------F 633
            F  RC   CL G A    G+ C  + +     G + +  C +                  
Sbjct: 105  FVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKI 164

Query: 634  PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDP 690
                 + E    N     G PC+        E    C  G  + +DG    D+NEC    
Sbjct: 165  IEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224

Query: 691  EVCANGV-CENLRGSYRCV----CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSP 744
              C  G  C N  GS+RC     C  GYE       C D+DEC      C   + CQN+ 
Sbjct: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 745  GSYSC----SCPPGFHFWQDT-EICKDVDECLS--SPCVSG-VCRNLAGSYTCK-----C 791
            GS+ C     C  GF   QD    C D++ECLS  +PC  G  C N  GSYTC+     C
Sbjct: 284  GSFRCRPKLQCKSGFI--QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341

Query: 792  GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEI 851
            G G  L+  GT C+D  +           C    +       C  + G+       RCE 
Sbjct: 342  GRGYHLNEEGTRCVDVDE-----------CAPPAEPCGKGHRCVNSPGSF------RCE- 383

Query: 852  DPACARGFARMTGVT--CDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909
               C  G+    G++  C DVNEC+ +PG     +C NT GS+ C C  G  L   GR C
Sbjct: 384  ---CKTGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439

Query: 910  VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969
             D+           +EC            C      V+G             +   C RG
Sbjct: 440  EDI-----------NECS--------SSPCSQECANVYG------------SYQCYCRRG 468

Query: 970  LGFASRDFLSGRPFYKDVNECKVFPG--LCTHGTCRNTVGSFHCAC-AGGFALDAQERNC 1026
               +  D ++     +D++EC +  G  +C++  C N  GSF C+C + G+ L    RNC
Sbjct: 469  YQLSDVDGVT----CEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC 523

Query: 1027 TDIDECRISPDLCG-QGTCVNTPGSFEC---ECFPGY-ESGFMLMKNCMDVDECARDPLL 1081
             DIDEC      C    TC N  G F C   EC   Y  S   L +   D   C +    
Sbjct: 524  QDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKS--- 580

Query: 1082 CRGGTCT 1088
            CR    T
Sbjct: 581  CRPNDVT 587



 Score =  159 bits (403), Expect = 3e-38
 Identities = 139/452 (30%), Positives = 194/452 (42%), Gaps = 90/452 (19%)

Query: 1371 DLCDNG-----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN-LCAFG-SCENLP 1423
            D C  G     QC +      C C +G+    D  +C+DV+EC  G+  C  G SC N  
Sbjct: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 1424 GMFRC----ICNGGYELDRGGGNCTDINECADPV-NCI-NGVCINTPGSYLCSCPQDFEL 1477
            G FRC     C  GYEL     +C DI+EC   + NC+ + +C NT GS+ C      + 
Sbjct: 238  GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
                 G +    GNC     D  +  +S SA   +G T   C  + G             
Sbjct: 297  -----GFIQDALGNCI----DINEC-LSISAPCPIGHT---CINTEG------------- 330

Query: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCECPPGYHL 1596
            + T  + +   G G+  N       D+DEC      C +G  CVN+ GSF+CEC  GY+ 
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1597 SEHTRICEDIDECSTHSG-ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR 1655
               +R+C D++EC  + G +CG   C NTLG+Y C C   +     G +C D+ +     
Sbjct: 391  DGISRMCVDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINE----- 444

Query: 1656 HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILC--GNQAPGFLTD 1713
                                CS       + PC      +   YQ  C  G Q    L+D
Sbjct: 445  --------------------CS-------SSPCSQECANVYGSYQCYCRRGYQ----LSD 473

Query: 1714 IHTGKPLDIDECGEIPA---ICANGICINQIGSFRCECP-AGFNYNSILLACEDVDECGS 1769
            +      DIDEC  +P    IC+   CIN  GSF+C CP +G+        C+D+DEC +
Sbjct: 474  VDGVTCEDIDECA-LPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531

Query: 1770 RESPCQQNADCINIPGSYRC---KCTRGYKLS 1798
                C  N  C NI G +RC   +C   Y+ S
Sbjct: 532  GIHNCSINETCFNIQGGFRCLAFECPENYRRS 563



 Score =  151 bits (382), Expect = 8e-36
 Identities = 115/358 (32%), Positives = 154/358 (43%), Gaps = 63/358 (17%)

Query: 409 IDICRHFTNLCL-NGRCLPTPSSYRC----ECNVGYTQDVRGECIDVDEC--TSSPCHHG 461
           ID C    + CL +  C  T  S+RC    +C  G+ QD  G CID++EC   S+PC  G
Sbjct: 263 IDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG 322

Query: 462 -DCVNIPGTYHCR-----CYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQC 514
             C+N  G+Y C+     C  G+        CVDVDEC      C  G RCVN+ GSF+C
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382

Query: 515 VCNAGFELSPDGKNCVDHNECA--TSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMD 572
            C  G+      + CVD NEC      +C    C N  GS+ C C  GF L+  G  C D
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSCED 441

Query: 573 IDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG-TDGRVCVDTHVRSTCYGAIEKGSCAR 631
           I+EC +     +  C N  GS++C C  G  +   DG  C D               CA 
Sbjct: 442 INECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDI------------DECAL 487

Query: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC-SSGLGITTDGR---DINECA 687
           P  G +    C                       FQ  C SSG  +  +GR   DI+EC 
Sbjct: 488 PTGGHICSYRC-----------------INIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530

Query: 688 LDPEVCA-NGVCENLRGSYRCV---CNLGYEAGAS--GKDCTD----VDECALNSLLC 735
                C+ N  C N++G +RC+   C   Y   A+   ++ TD    +  C  N + C
Sbjct: 531 TGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTC 588



 Score =  147 bits (370), Expect = 2e-34
 Identities = 137/465 (29%), Positives = 181/465 (38%), Gaps = 77/465 (16%)

Query: 193 PEGCQHQLTGLVCTKALCCATVGRA---WGLPCELCPAQPHPCRRGF---------IPNI 240
           P G    L      +   C  +GRA    G  CE      + C + F           ++
Sbjct: 94  PHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDL 153

Query: 241 HTGACQDVD------ECQAVPGL---CQGGS-----CVNMVGSFHCRCPVGHRLSDSSAA 286
             G  Q+ D      E Q  P L   C+GG      C +      C C VG++L     +
Sbjct: 154 DVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVS 213

Query: 287 CEDYRA--GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
           CED         S   G  C   +     +R   C  G         EL       +  +
Sbjct: 214 CEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY--------ELTEDNSCKDIDE 265

Query: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
                        G+   L  F        LG  R  P      G      GN       
Sbjct: 266 C----------ESGIHNCLPDFICQNT---LGSFRCRPKLQCKSGFIQDALGNC------ 306

Query: 405 LNQTIDI--CRHFTNLCLNGR-CLPTPSSYRCECNV-----GYTQDVRG-ECIDVDECT- 454
               IDI  C   +  C  G  C+ T  SY C+ NV     GY  +  G  C+DVDEC  
Sbjct: 307 ----IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP 362

Query: 455 -SSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512
            + PC  G  CVN PG++ C C  G+      + CVDV+EC    G     +C NT GS+
Sbjct: 363 PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSY 422

Query: 513 QCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAP-GGHYCM 571
            C C+ GF LS DG++C D NEC++S    +  C N  GS+ C C+ G+ L+   G  C 
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 572 DIDECQTP--GICVNGHCTNTEGSFRCQC-LGGLAVGTDGRVCVD 613
           DIDEC  P  G   +  C N  GSF+C C   G  +  +GR C D
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525



 Score =  135 bits (340), Expect = 6e-31
 Identities = 107/357 (29%), Positives = 158/357 (44%), Gaps = 61/357 (17%)

Query: 244 ACQDVDECQAVPGLCQ-GGSCVNMVGSFHCR----CPVGHRLSDSSAACEDY---RAGA- 294
           +C+DV+EC      C+ G SC+N VGSF C+    C  G+ L++ ++ C+D     +G  
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIH 271

Query: 295 -------CFSVLFGGRCAGDLAGHYTRRQC-----------CCDRGRCWAAG---PVPEL 333
                  C + L   RC   L       QC           C D   C +     P+   
Sbjct: 272 NCLPDFICQNTLGSFRCRPKL-------QCKSGFIQDALGNCIDINECLSISAPCPIGHT 324

Query: 334 CPPRGSNEFQQLCAQRLPLLP-GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPS 392
           C    + E    C + +P    G+     G      +   PP  P      G   R + S
Sbjct: 325 CI---NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-----GKGHRCVNS 376

Query: 393 LGP-------GNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRG 445
            G        G    G + +   ++ C+ +       +C  T  SY C C+VG+   V G
Sbjct: 377 PGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDG 436

Query: 446 -ECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPT-RQACVDVDEC-IVSGGLCHL 502
             C D++EC+SSPC   +C N+ G+Y C C  G+Q +      C D+DEC + +GG    
Sbjct: 437 RSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS 495

Query: 503 GRCVNTEGSFQCVC-NAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSCL 556
            RC+N  GSFQC C ++G+ L+P+G+NC D +EC T      +N  C N  G F CL
Sbjct: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 102/407 (25%), Positives = 135/407 (33%), Gaps = 116/407 (28%)

Query: 85  ICRRACGEGFCSQPNLCTCADGTLAPSCG----VSRGSGCSVSCMNGGTCRGA--SCLCQ 138
           IC+   G   C +P L  C  G +  + G    ++     S  C  G TC     S  CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 139 KGYTGTVCGQPICDRGCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG 195
           K         P C RG H    G RC+  + CA       P  E   +   C    G   
Sbjct: 336 KNV-------PNCGRGYHLNEEGTRCVDVDECA-------PPAEPCGKGHRCVNSPGSFR 381

Query: 196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVP 255
           C+                                  C+ G+  +  +  C DV+ECQ  P
Sbjct: 382 CE----------------------------------CKTGYYFDGISRMCVDVNECQRYP 407

Query: 256 GLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR 315
           G   G  C N +GS+ C C VG RLS    +CED     C S      C+ + A  Y   
Sbjct: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INECSS----SPCSQECANVYGSY 461

Query: 316 QCCCDRGRCWA------AGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSN 369
           QC C RG   +         + E   P G +    +C+ R   +P            GS 
Sbjct: 462 QCYCRRGYQLSDVDGVTCEDIDECALPTGGH----ICSYRCINIP------------GSF 505

Query: 370 GMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDIC-RHFTNLCLNGRCLPTP 428
               P    RL P+G +                    Q ID C     N  +N  C    
Sbjct: 506 QCSCPSSGYRLAPNGRNC-------------------QDIDECVTGIHNCSINETCFNIQ 546

Query: 429 SSYRC---ECNVGYTQD---VRGECIDVDECTSSPCHHGD--CVNIP 467
             +RC   EC   Y +    ++ E  D   C  S C   D  CV  P
Sbjct: 547 GGFRCLAFECPENYRRSAATLQQEKTDTVRCIKS-CRPNDVTCVFDP 592



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 112/449 (24%), Positives = 151/449 (33%), Gaps = 92/449 (20%)

Query: 86  CRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSV--SCMNGG-TCR-GASCLCQKGY 141
           C++ C +       +C+C  G    S GVS    C     C+ G  +CR G SC+   G 
Sbjct: 186 CKQQCRD--TGDEVVCSCFVGYQLLSDGVS----CEDVNECITGSHSCRLGESCINTVG- 238

Query: 142 TGTVCGQPICDRGCHNGGRCIGPNRCA----CVYGFMGPQCERDYRTGPCFGQVGPEGCQ 197
               C +   D  C  G      N C     C  G     C  D+    C   +G   C+
Sbjct: 239 -SFRCQR---DSSCGTGYELTEDNSCKDIDECESGIHN--CLPDFI---CQNTLGSFRCR 289

Query: 198 HQL---TGLVCTKALCCATVGRAWGL--PCEL------------CPAQPHPCRRGFIPNI 240
            +L   +G +      C  +     +  PC +            C      C RG+  N 
Sbjct: 290 PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 241 HTGACQDVDECQAVPGLC-QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF-SV 298
               C DVDEC      C +G  CVN  GSF C C  G+     S  C D      +   
Sbjct: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409

Query: 299 LFGGRCAGDLAGHYTRRQCCCDRG-RCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHP 357
           L G +C   L  +     C C  G R    G   E      S+   Q CA          
Sbjct: 410 LCGHKCENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECA---------- 455

Query: 358 GLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTN 417
                      N  G      R     SD  G+        +I    L     IC +   
Sbjct: 456 -----------NVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGGHICSY--- 496

Query: 418 LCLNGRCLPTPSSYRCEC-NVGYTQDVRG-ECIDVDECTSS--PCHHGD-CVNIPGTYHC 472
                RC+  P S++C C + GY     G  C D+DEC +    C   + C NI G + C
Sbjct: 497 -----RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551

Query: 473 ---RCYPGFQ--ATPTRQACVDVDECIVS 496
               C   ++  A   +Q   D   CI S
Sbjct: 552 LAFECPENYRRSAATLQQEKTDTVRCIKS 580


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  243 bits (621), Expect = 1e-63
 Identities = 155/424 (36%), Positives = 203/424 (47%), Gaps = 61/424 (14%)

Query: 1069 CMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQ 1128
            C D DECA         +C N  G+Y C CP G  + A G  C+DIDEC+L    C  GQ
Sbjct: 5105 CADEDECAAGNPCSH--SCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQ 5162

Query: 1129 -CVNVIGAFQC--SCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGY 1185
             C N IG+++C   C +GF+ T D   C DINEC+ ++  C   C N  GS+ C C  GY
Sbjct: 5163 DCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ-ESSPCHQRCFNAIGSFHCGCEPGY 5221

Query: 1186 SLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRC--LCYDGFMATPDMRTCVDVDECD 1243
             L   GR C DV+EC +N    DQ HC N  GG++C  LC +G M   +  TC+D+DEC 
Sbjct: 5222 QLK--GRKCMDVNECRQNVCRPDQ-HCKNTRGGYKCIDLCPNG-MTKAENGTCIDIDECK 5277

Query: 1244 LNPHICLHGD-CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPG 1302
               H C +   CENT+GS+ C C  GY  +     C D++ECE     C +H  C N PG
Sbjct: 5278 DGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPC-AH-QCSNTPG 5335

Query: 1303 SFSCRCLPGW--VGDGFECHDLDECVS--------------------------------- 1327
            SF C C PG   +GDG  C  L+   +                                 
Sbjct: 5336 SFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLY 5395

Query: 1328 ---QEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGG 1384
                E+R S R        + R TC +G       C D DEC EN D C + +C N  G 
Sbjct: 5396 SSYSEYRNS-RTSLSRTRRTIRKTCPEGSEASHDTCVDIDEC-ENTDACQH-ECKNTFGS 5452

Query: 1385 YRCECEMGFDPTEDHRACQDVDECAQGNL-CAFG-SCENLPGMFRCI---CNGGYELDRG 1439
            Y+C C  G+  T + + CQD+DEC + N+ C     C N+ G ++CI   C   Y+ D  
Sbjct: 5453 YQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPV 5512

Query: 1440 GGNC 1443
             G C
Sbjct: 5513 SGFC 5516



 Score =  239 bits (609), Expect = 4e-62
 Identities = 156/468 (33%), Positives = 205/468 (43%), Gaps = 96/468 (20%)

Query: 2164 CEDIDECSL-NPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222
            C D DEC+  NP  C+  CHN  G+Y C+CP G T+  DG  C+D+DECA G+  CHA G
Sbjct: 5105 CADEDECAAGNP--CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHA-G 5161

Query: 2223 MECKNLIGTFACV--CPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD 2280
             +C N IG++ CV  C  G R     G  C D NEC  Q     + RC N  GSF C C+
Sbjct: 5162 QDCDNTIGSYRCVVRCGSGFRRT-SDGLSCQDINEC--QESSPCHQRCFNAIGSFHCGCE 5218

Query: 2281 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP 2340
             G+Q      +C D+ +           CR      + V R +  C   RG     +LCP
Sbjct: 5219 PGYQLKGR--KCMDVNE-----------CR------QNVCRPDQHCKNTRGGYKCIDLCP 5259

Query: 2341 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGE-CINSLGSFRCHCQAGYTPDAT 2399
               T A    C           D+DEC+   H C + + C N+ GS+RC C  GY     
Sbjct: 5260 NGMTKAENGTCI----------DIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGV 5309

Query: 2400 ATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTS------- 2452
               C+D++EC QVPKPC   C NT GSF C CP G  L  DG++C  L+   +       
Sbjct: 5310 GRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSS 5369

Query: 2453 ---------------RQH---------------NCQFLCVNTVGAFTCRCPPGFTQHHQA 2482
                           +QH               N +     T       CP G    H  
Sbjct: 5370 YNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDT 5429

Query: 2483 CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC------DGPH 2536
            C D DEC            C NT GS++C C  G+ L  +G  C+D++EC       GP+
Sbjct: 5430 CVDIDECE---NTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPN 5486

Query: 2537 RCQHGCQNQLGGYRC---SCPQGFTQHSQWAQCV-----DENECALSP 2576
            R    C N  G Y+C    CP  + +      C+     ++ ECALSP
Sbjct: 5487 RM---CFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSP 5531



 Score =  230 bits (586), Expect = 2e-59
 Identities = 153/443 (34%), Positives = 198/443 (44%), Gaps = 32/443 (7%)

Query: 1211 HCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDL-NPHICLHGDCENTKGSFVCHCQLGY 1269
            H +   G     C  GF        C D DEC   NP  C H  C N  G++ C C  G 
Sbjct: 5080 HASISKGDRSNQCPSGFTLDSVGPFCADEDECAAGNP--CSHS-CHNAMGTYYCSCPKGL 5136

Query: 1270 MVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC--RCLPGW--VGDGFECHDLDEC 1325
             +      C D+DEC +G H C +   C N  GS+ C  RC  G+    DG  C D++EC
Sbjct: 5137 TIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINEC 5196

Query: 1326 VSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGY 1385
              +   C  R  C N  GS+ C C  G+   G  C D +EC +NV   D   C N  GGY
Sbjct: 5197 -QESSPCHQR--CFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQ-HCKNTRGGY 5252

Query: 1386 RCE--CEMGFDPTEDHRACQDVDECAQG-NLCAFGS-CENLPGMFRCICNGGYELDRGGG 1441
            +C   C  G    E+   C D+DEC  G + C +   CEN  G +RC+C  GY     G 
Sbjct: 5253 KCIDLCPNGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGR 5311

Query: 1442 NCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA----GNCFLETH 1497
             C DINEC          C NTPGS+ C CP    L   G  C         G  +   +
Sbjct: 5312 PCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYN 5371

Query: 1498 DRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRI 1557
                S +  + +      + S   S    + N          T  R  CP  EG + +  
Sbjct: 5372 LARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRT-IRKTCP--EGSEASHD 5428

Query: 1558 TVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICG 1617
            T +  DIDEC+     CQ  +C NTFGS+QC CPPGY L+ + + C+DIDEC   +  CG
Sbjct: 5429 TCV--DIDECENTDA-CQ-HECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCG 5484

Query: 1618 PG-TCYNTLGNYTCV---CPAEY 1636
            P   C+N  G+Y C+   CP  Y
Sbjct: 5485 PNRMCFNMRGSYQCIDTPCPPNY 5507



 Score =  214 bits (544), Expect = 1e-54
 Identities = 158/488 (32%), Positives = 213/488 (43%), Gaps = 99/488 (20%)

Query: 895  ECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEAC 954
            +CP G  LD+ G  C D           EDEC    P         CS          +C
Sbjct: 5091 QCPSGFTLDSVGPFCAD-----------EDECAAGNP---------CS---------HSC 5121

Query: 955  PDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT-CRNTVGSFHCA- 1012
             +     + S CP+GL  A+     GR   +D++EC +    C  G  C NT+GS+ C  
Sbjct: 5122 HNAMGTYYCS-CPKGLTIAA----DGRTC-QDIDECALGRHTCHAGQDCDNTIGSYRCVV 5175

Query: 1013 -CAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMD 1071
             C  GF   +   +C DI+EC+ S   C Q  C N  GSF C C PGY+   +  + CMD
Sbjct: 5176 RCGSGFRRTSDGLSCQDINECQESSP-CHQ-RCFNAIGSFHCGCEPGYQ---LKGRKCMD 5230

Query: 1072 VDECARDPLLCRGGT-CTNTDGSYKC--QCPPGHELTAKGTACEDIDECSLSDGLCPHGQ 1128
            V+EC ++  +CR    C NT G YKC   CP G      GT C DIDEC      C + Q
Sbjct: 5231 VNECRQN--VCRPDQHCKNTRGGYKCIDLCPNGMTKAENGT-CIDIDECKDGTHQCRYNQ 5287

Query: 1129 -CVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSL 1187
             C N  G+++C C  G++S    + C+DINEC      C   C NT GS++C C  G  L
Sbjct: 5288 ICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHL 5347

Query: 1188 MPDGRACADVDECEENPRVCDQGHCTNM-----------PGGH----------------- 1219
            + DG++CA +   E  P    Q    N+           P  H                 
Sbjct: 5348 LGDGKSCAGL---ERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNS 5404

Query: 1220 -----------RCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLG 1268
                       R  C +G  A+ D  TCVD+DEC+ N   C H +C+NT GS+ C C  G
Sbjct: 5405 RTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECE-NTDACQH-ECKNTFGSYQCICPPG 5460

Query: 1269 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC---RCLPGWVGDGFECHDLDEC 1325
            Y +      C D+DEC     +C  +  C N+ GS+ C    C P +  D      L  C
Sbjct: 5461 YQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNC 5520

Query: 1326 VSQEHRCS 1333
               +  C+
Sbjct: 5521 PPNDLECA 5528



 Score =  205 bits (521), Expect = 6e-52
 Identities = 110/281 (39%), Positives = 146/281 (51%), Gaps = 17/281 (6%)

Query: 2382 SLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDG 2441
            S G     C +G+T D+    C D DEC+    PC+  C N  G++ CSCP+G  +  DG
Sbjct: 5084 SKGDRSNQCPSGFTLDSVGPFCADEDECA-AGNPCSHSCHNAMGTYYCSCPKGLTIAADG 5142

Query: 2442 RTCKDLDECTSRQHNCQFL--CVNTVGAFTC--RCPPGF--TQHHQACFDNDECSAQPGP 2495
            RTC+D+DEC   +H C     C NT+G++ C  RC  GF  T    +C D +EC  +  P
Sbjct: 5143 RTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ-ESSP 5201

Query: 2496 CGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHGCQNQLGGYRCS-- 2552
            C  H  C N  GSF C C  G+ L   G  C DVNEC     R    C+N  GGY+C   
Sbjct: 5202 C--HQRCFNAIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDL 5257

Query: 2553 CPQGFTQHSQWAQCVDENECALSPPTCG-SASCRNTLGGFRCVCPSGFDFDQALGGCQEV 2611
            CP G T+ ++   C+D +EC      C  +  C NT G +RCVCP G+        C ++
Sbjct: 5258 CPNGMTK-AENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDI 5316

Query: 2612 DECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGL 2652
            +EC     PC++ C+NTPG F C CP G    G G   +GL
Sbjct: 5317 NECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGL 5357



 Score =  203 bits (517), Expect = 2e-51
 Identities = 157/516 (30%), Positives = 220/516 (42%), Gaps = 74/516 (14%)

Query: 1705 NQAP-GFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACED 1763
            NQ P GF  D       D DEC      C++  C N +G++ C CP G    +    C+D
Sbjct: 5090 NQCPSGFTLDSVGPFCADEDECAAGNP-CSHS-CHNAMGTYYCSCPKGLTIAADGRTCQD 5147

Query: 1764 VDECGSRESPCQQNADCINIPGSYRC--KCTRGY-KLSPGGACVGRNECREIPNVCSHGD 1820
            +DEC      C    DC N  GSYRC  +C  G+ + S G +C   NEC+E  + C H  
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQE-SSPC-HQR 5205

Query: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPC-GNGTCKNIIGSYNC--LCFPGFV 1877
            C +  GS+ C C  G+Q    +  CMD++EC +  C  +  CKN  G Y C  LC  G  
Sbjct: 5206 CFNAIGSFHCGCEPGYQLKGRK--CMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMT 5263

Query: 1878 VTHNGDCVDFDECTTLVGQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSL 1936
               NG C+D DEC     Q CR+   C NT GS+ C+C  G+     G+ C+D NEC  +
Sbjct: 5264 KAENGTCIDIDECKDGTHQ-CRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQV 5322

Query: 1937 AGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLC 1996
               C    C N  GSF+CICPPG  +  D       C+    L  +GT  +S    +   
Sbjct: 5323 PKPC-AHQCSNTPGSFKCICPPGQHLLGDG----KSCAGLERLPNYGTQYSSYNLARFSP 5377

Query: 1997 PPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELC 2056
                      +R +    S  ++ +   + S+ +   T +  C                 
Sbjct: 5378 VRNNYQPQQHYRQYSHLYS-SYSEYRNSRTSLSRTRRTIRKTC----------------- 5419

Query: 2057 PQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYS 2116
              EGS A  + C               D++EC EN   C +  C NT GS++C CP GY 
Sbjct: 5420 -PEGSEASHDTC--------------VDIDEC-ENTDACQH-ECKNTFGSYQCICPPGYQ 5462

Query: 2117 LDFTGINCVDTDEC-SVGHPCGQG-TCTNVIGGFEC---ACADGFEPG-----LMMTCED 2166
            L   G  C D DEC      CG    C N+ G ++C    C   ++        +  C  
Sbjct: 5463 LTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPP 5522

Query: 2167 ID-ECSLNPLLCAFRCHNTEGSYLCTCPAGYTLRED 2201
             D EC+L+P    ++        L + P G    +D
Sbjct: 5523 NDLECALSPYALEYK--------LVSLPFGIATNQD 5550



 Score =  184 bits (467), Expect = 1e-45
 Identities = 130/418 (31%), Positives = 175/418 (41%), Gaps = 81/418 (19%)

Query: 434  ECNVGYTQDVRGE-CIDVDECTS-SPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVD 491
            +C  G+T D  G  C D DEC + +PC H  C N  GTY+C C  G       + C D+D
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 492  ECIVSGGLCHLGR-CVNTEGSFQCV--CNAGFELSPDGKNCVDHNECATSTMCVNGVCLN 548
            EC +    CH G+ C NT GS++CV  C +GF  + DG +C D NEC  S+ C +  C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC-HQRCFN 5208

Query: 549  EDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRC--QCLGGLAVGT 606
              GSF C C+PG+ L   G  CMD++EC+      + HC NT G ++C   C  G+    
Sbjct: 5209 AIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAE 5266

Query: 607  DGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN--PDHGFGEPCQLCPAKDSA 664
            +G  C+D      C     +    +    T     C C       G G PC         
Sbjct: 5267 NG-TCIDI---DECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCM-------- 5314

Query: 665  EFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTD 724
                             DINEC   P+ CA+  C N  GS++C+C  G      GK C  
Sbjct: 5315 -----------------DINECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGDGKSCAG 5356

Query: 725  VD------------ECALNSLLCDNGWCQNSPGSYS------------------------ 748
            ++              A  S + +N   Q     YS                        
Sbjct: 5357 LERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIR 5416

Query: 749  CSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLD 806
             +CP G     DT  C D+DEC ++      C+N  GSY C C PG +L  +G  C D
Sbjct: 5417 KTCPEGSEASHDT--CVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQD 5472



 Score =  179 bits (455), Expect = 3e-44
 Identities = 140/471 (29%), Positives = 192/471 (40%), Gaps = 60/471 (12%)

Query: 1349 CRQGFAGD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD 1406
            C  GF  D  G FC D DECA   + C +  C NA G Y C C  G     D R CQD+D
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAG-NPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 1407 ECAQG-NLCAFGS-CENLPGMFRCI--CNGGYELDRGGGNCTDINECADPVNCINGVCIN 1462
            ECA G + C  G  C+N  G +RC+  C  G+     G +C DINEC +   C +  C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC-HQRCFN 5208

Query: 1463 TPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCS 1522
              GS+ C C   ++L   G  C+D                      E    V R    C 
Sbjct: 5209 AIGSFHCGCEPGYQLK--GRKCMDVN--------------------ECRQNVCRPDQHCK 5246

Query: 1523 LGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD-CVN 1581
              R      +LCP   T      C                DIDEC++    C+    C N
Sbjct: 5247 NTRGGYKCIDLCPNGMTKAENGTCI---------------DIDECKDGTHQCRYNQICEN 5291

Query: 1582 TFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNG 1641
            T GS++C CP GY      R C DI+EC      C    C NT G++ C+CP     +  
Sbjct: 5292 TRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGD 5350

Query: 1642 GNNCMDMRK----SVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISP 1697
            G +C  + +       +  YN    + +  N   +     Y+   +         T +S 
Sbjct: 5351 GKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSR 5410

Query: 1698 DYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSI 1757
              + +      G  ++      +DIDEC    A C +  C N  GS++C CP G+     
Sbjct: 5411 TRRTIRKTCPEG--SEASHDTCVDIDECENTDA-CQHE-CKNTFGSYQCICPPGYQLTHN 5466

Query: 1758 LLACEDVDECGSRESPCQQNADCINIPGSYRC---KCTRGYKLSP-GGACV 1804
               C+D+DEC  +   C  N  C N+ GSY+C    C   Y+  P  G C+
Sbjct: 5467 GKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCL 5517



 Score =  179 bits (454), Expect = 3e-44
 Identities = 123/392 (31%), Positives = 163/392 (41%), Gaps = 56/392 (14%)

Query: 1140 CHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDE 1199
            C +GF        C D +EC   N  C   C N  G+Y CSC +G ++  DGR C D+DE
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDE 5150

Query: 1200 CEENPRVCDQGH-CTNMPGGHRCL--CYDGFMATPDMRTCVDVDECDLNPHICLHGDCEN 1256
            C      C  G  C N  G +RC+  C  GF  T D  +C D++EC  +     H  C N
Sbjct: 5151 CALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC--HQRCFN 5208

Query: 1257 TKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC--RCLPGWV- 1313
              GSF C C+ GY ++     C DV+EC       D H  C N  G + C   C  G   
Sbjct: 5209 AIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQH--CKNTRGGYKCIDLCPNGMTK 5264

Query: 1314 GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFF--CEDRDECAENVD 1371
             +   C D+DEC    H+C     C N  GSYRC C +G+   G    C D +EC +   
Sbjct: 5265 AENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPK 5324

Query: 1372 LCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD-------ECAQGNLCAFGSCEN--- 1421
             C + QC N PG ++C C  G     D ++C  ++       + +  NL  F    N   
Sbjct: 5325 PCAH-QCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQ 5383

Query: 1422 ---------------------------LPGMFRCICNGGYELDRGGGNCTDINECADPVN 1454
                                            R  C  G E       C DI+EC +   
Sbjct: 5384 PQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECENTDA 5441

Query: 1455 CINGVCINTPGSYLCSCPQDFELNPSGVGCVD 1486
            C +  C NT GSY C CP  ++L  +G  C D
Sbjct: 5442 CQHE-CKNTFGSYQCICPPGYQLTHNGKTCQD 5472



 Score =  178 bits (451), Expect = 8e-44
 Identities = 105/290 (36%), Positives = 137/290 (47%), Gaps = 16/290 (5%)

Query: 1165 GCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEE-NPRVCDQGHCTNMPGGHRCLC 1223
            G  +H   ++G     C  G++L   G  CAD DEC   NP  C    C N  G + C C
Sbjct: 5076 GFKIHASISKGDRSNQCPSGFTLDSVGPFCADEDECAAGNP--CSHS-CHNAMGTYYCSC 5132

Query: 1224 YDGFMATPDMRTCVDVDECDLNPHICLHG-DCENTKGSFVCHCQLGYMVRKGATG--CSD 1280
              G     D RTC D+DEC L  H C  G DC+NT GS+ C  + G   R+ + G  C D
Sbjct: 5133 PKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQD 5192

Query: 1281 VDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLN 1340
            ++EC+    +   H  C N  GSF C C PG+   G +C D++EC  +++ C P   C N
Sbjct: 5193 INECQ---ESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNEC--RQNVCRPDQHCKN 5247

Query: 1341 VPGSYRCT--CRQGFA-GDGFFCEDRDECAENVDLCDNGQ-CLNAPGGYRCECEMGFDPT 1396
              G Y+C   C  G    +   C D DEC +    C   Q C N  G YRC C  G+   
Sbjct: 5248 TRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQ 5307

Query: 1397 EDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDI 1446
               R C D++EC Q        C N PG F+CIC  G  L   G +C  +
Sbjct: 5308 GVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGL 5357



 Score =  172 bits (435), Expect = 5e-42
 Identities = 153/487 (31%), Positives = 200/487 (41%), Gaps = 63/487 (12%)

Query: 621  YGAIEKGSCARPFPGTVTKSEC--CCANPDH-GFGEPCQLCPAKDSAEFQALCSSGLGIT 677
            + +I KG  +   P   T       CA+ D    G PC          +   C  GL I 
Sbjct: 5080 HASISKGDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIA 5139

Query: 678  TDGR---DINECALDPEVCANGV-CENLRGSYRCV--CNLGYEAGASGKDCTDVDECALN 731
             DGR   DI+ECAL    C  G  C+N  GSYRCV  C  G+   + G  C D++EC  +
Sbjct: 5140 ADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQES 5199

Query: 732  SLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGV-CRNLAGSYTCK 790
            S       C N+ GS+ C C PG+        C DV+EC  + C     C+N  G Y C 
Sbjct: 5200 SPCHQR--CFNAIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQHCKNTRGGYKC- 5254

Query: 791  CGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCE 850
                  L P+G     +  GTC   I    C+           C  T G+       RC 
Sbjct: 5255 ----IDLCPNGM--TKAENGTC---IDIDECKDGTHQCRYNQICENTRGSY------RC- 5298

Query: 851  IDPACARGF-ARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909
                C RG+ ++  G  C D+NECE  P  C + +C NT GSF+C CP G  L   G+ C
Sbjct: 5299 ---VCPRGYRSQGVGRPCMDINECEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGDGKSC 5354

Query: 910  VDVRLEPCF-LRWDEDECGVTLP--GKYRMDVCCCSIGAVWGVECEACPDPESLE----- 961
              +   P +  ++         P    Y+          ++    E      SL      
Sbjct: 5355 AGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRT 5414

Query: 962  FASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDA 1021
                CP G   AS D         D++EC+     C H  C+NT GS+ C C  G+ L  
Sbjct: 5415 IRKTCPEG-SEASHDTC------VDIDECE-NTDACQH-ECKNTFGSYQCICPPGYQLTH 5465

Query: 1022 QERNCTDIDECRISPDLCGQG-TCVNTPGSFEC---ECFPGYE----SGFMLMKNCMDVD 1073
              + C DIDEC      CG    C N  GS++C    C P Y+    SGF L KNC   D
Sbjct: 5466 NGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCL-KNCPPND 5524

Query: 1074 -ECARDP 1079
             ECA  P
Sbjct: 5525 LECALSP 5531



 Score =  170 bits (430), Expect = 2e-41
 Identities = 125/419 (29%), Positives = 173/419 (41%), Gaps = 62/419 (14%)

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICED 1605
            CP G  F  + +     D DEC    G      C N  G++ C CP G  ++   R C+D
Sbjct: 5092 CPSG--FTLDSVGPFCADEDECAA--GNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQD 5147

Query: 1606 IDECSTHSGICGPG-TCYNTLGNYTCV--CPAEYLQVNGGNNCMDMRK----SVCF-RHY 1657
            IDEC+     C  G  C NT+G+Y CV  C + + + + G +C D+ +    S C  R +
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCF 5207

Query: 1658 NGT----CQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTD 1713
            N      C  E  + +  + C       Q   RP + C       Y+  C +  P  +T 
Sbjct: 5208 NAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKN-TRGGYK--CIDLCPNGMTK 5264

Query: 1714 IHTGKPLDIDECGEIPAICA-NGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRES 1772
               G  +DIDEC +    C  N IC N  GS+RC CP G+    +   C D++EC     
Sbjct: 5265 AENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPK 5324

Query: 1773 PCQQNADCINIPGSYRCKCTRG-YKLSPGGACVG----------------------RNEC 1809
            PC     C N PGS++C C  G + L  G +C G                      RN  
Sbjct: 5325 PCAH--QCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNY 5382

Query: 1810 REIPNVCSHGDCMDTEGSY--------------MCLCHRGFQASADQTLCMDIDECDRQP 1855
            +   +   +     +   Y                 C  G +AS D   C+DIDEC+   
Sbjct: 5383 QPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECENTD 5440

Query: 1856 CGNGTCKNIIGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGHCLNTAGSFHCL 1913
                 CKN  GSY C+C PG+ +THNG  C D DEC            C N  GS+ C+
Sbjct: 5441 ACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCI 5499



 Score =  167 bits (424), Expect = 1e-40
 Identities = 113/340 (33%), Positives = 148/340 (43%), Gaps = 60/340 (17%)

Query: 2351 CPHGSGYTAEGR---DVDECRMLAHLCAHGE-CINSLGSFRC--HCQAGYTPDATATTCL 2404
            CP G    A+GR   D+DEC +  H C  G+ C N++GS+RC   C +G+   +   +C 
Sbjct: 5132 CPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQ 5191

Query: 2405 DMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQ--FLCV 2462
            D++EC Q   PC   C N  GSF C C  GY L+  GR C D++EC  RQ+ C+    C 
Sbjct: 5192 DINEC-QESSPCHQRCFNAIGSFHCGCEPGYQLK--GRKCMDVNEC--RQNVCRPDQHCK 5246

Query: 2463 NTVGAFTC--RCPPGFTQ-HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTL 2519
            NT G + C   CP G T+  +  C D DEC      C  +  C NT GS+RC C +G+  
Sbjct: 5247 NTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRS 5306

Query: 2520 VSSGHGCEDVNECDG-PHRCQHGCQNQLGGYRCSCPQGFTQH---------------SQW 2563
               G  C D+NEC+  P  C H C N  G ++C CP G  QH               +  
Sbjct: 5307 QGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPG--QHLLGDGKSCAGLERLPNYG 5364

Query: 2564 AQCVDENECALSPPTCG-----------------------SASCRNTLGGFRCVCPSGFD 2600
             Q    N    SP                             S   T    R  CP G +
Sbjct: 5365 TQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSE 5424

Query: 2601 FDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2640
                   C ++DEC      C + C NT G + C CP GY
Sbjct: 5425 ASHDT--CVDIDECENTDA-CQHECKNTFGSYQCICPPGY 5461



 Score =  166 bits (421), Expect = 2e-40
 Identities = 141/473 (29%), Positives = 198/473 (41%), Gaps = 76/473 (16%)

Query: 837  TLGAAWGSPCERCEIDPACARGFAR-MTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCE 895
            TLG    +   + +    C  GF     G  C D +EC +  G   +  C N  G++ C 
Sbjct: 5074 TLGFKIHASISKGDRSNQCPSGFTLDSVGPFCADEDECAA--GNPCSHSCHNAMGTYYCS 5131

Query: 896  CPEGLMLDASGRLCVDVRLEPCFLRWDE----DECGVTLPGKYRMDVCCCSIGAVWGVEC 951
            CP+GL + A GR C D+  + C L         +C  T+ G YR  V C S G     + 
Sbjct: 5132 CPKGLTIAADGRTCQDI--DECALGRHTCHAGQDCDNTI-GSYRCVVRCGS-GFRRTSDG 5187

Query: 952  EACPDPESLEFASLCPRGLGFASRDFLSG-RPFYK-------DVNECKVFPGLCTHGT-C 1002
             +C D    + +S C +    A   F  G  P Y+       DVNEC+    +C     C
Sbjct: 5188 LSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECR--QNVCRPDQHC 5245

Query: 1003 RNTVGSFHCA--CAGGFALDAQERNCTDIDECRISPDLCGQGT-CVNTPGSFECECFPGY 1059
            +NT G + C   C  G    A+   C DIDEC+     C     C NT GS+ C C  GY
Sbjct: 5246 KNTRGGYKCIDLCPNGMT-KAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGY 5304

Query: 1060 ESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDEC-- 1117
             S  +  + CMD++EC + P  C    C+NT GS+KC CPPG  L   G +C  ++    
Sbjct: 5305 RSQGV-GRPCMDINECEQVPKPC-AHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN 5362

Query: 1118 ----------------------------------SLSDGLCPHGQCVNVIGAFQCSCHAG 1143
                                              S S+               + +C  G
Sbjct: 5363 YGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEG 5422

Query: 1144 FQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC-EE 1202
             +++ D   CVDI+EC      C   C NT GSY+C C  GY L  +G+ C D+DEC E+
Sbjct: 5423 SEASHDT--CVDIDECE-NTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQ 5479

Query: 1203 NPRVCDQGHCTNMPGGHRCL---CYDGFMATP----DMRTCVDVD-ECDLNPH 1247
            N        C NM G ++C+   C   +   P     ++ C   D EC L+P+
Sbjct: 5480 NVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPY 5532



 Score =  162 bits (409), Expect = 6e-39
 Identities = 134/455 (29%), Positives = 175/455 (38%), Gaps = 125/455 (27%)

Query: 2110 ECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDID 2168
            +CP G++LD  G  C D DEC+ G+PC   +C N +G + C+C  G        TC+DID
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNPCSH-SCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 2169 ECSLNPLLC--AFRCHNTEGSYLCT--CPAGYTLREDGAMCRDVDECADGQQDCHARGME 2224
            EC+L    C     C NT GSY C   C +G+    DG  C+D++EC +    CH R   
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQE-SSPCHQR--- 5205

Query: 2225 CKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQP-----------------DLCVNGR 2267
            C N IG+F C C PG +     G  C D NEC                     DLC NG 
Sbjct: 5206 CFNAIGSFHCGCEPGYQL---KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGM 5262

Query: 2268 --------------------------CVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCF 2301
                                      C NT GS+RC C  G++       C DI +    
Sbjct: 5263 TKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINE---- 5318

Query: 2302 AEVLQTMCRSLSSSSEAVTRAECCCGGGR---GWGPRC---ELCPLPGT--SAY------ 2347
             E +   C    S++      +C C  G+   G G  C   E  P  GT  S+Y      
Sbjct: 5319 CEQVPKPCAHQCSNTPG--SFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFS 5376

Query: 2348 ---------------------------------------RKLCPHGSGYTAEG-RDVDEC 2367
                                                   RK CP GS  + +   D+DEC
Sbjct: 5377 PVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDEC 5436

Query: 2368 RMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPC--TFLCKNTKG 2425
                  C H EC N+ GS++C C  GY       TC D+DEC +    C    +C N +G
Sbjct: 5437 EN-TDACQH-ECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRG 5494

Query: 2426 SFLC---SCPRGYLLEEDGRTCKDLDECTSRQHNC 2457
            S+ C    CP  Y  +     C  L  C      C
Sbjct: 5495 SYQCIDTPCPPNYQRDPVSGFC--LKNCPPNDLEC 5527



 Score =  147 bits (371), Expect = 1e-34
 Identities = 126/430 (29%), Positives = 169/430 (39%), Gaps = 96/430 (22%)

Query: 1914 CQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDID 1971
            C  GF L + G  C D +EC   AG     +C N  G++ C CP G  + +D   C DID
Sbjct: 5092 CPSGFTLDSVGPFCADEDECA--AGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 1972 ECSEEPNLCLFGT-CTNSPGSFQCL--CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
            EC+   + C  G  C N+ GS++C+  C  GF  + +G  C D  +              
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINE-------------- 5195

Query: 2029 PKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSRE---DV 2085
                        C +        PC          F  +  F  G  PG         DV
Sbjct: 5196 ------------CQE------SSPCH------QRCFNAIGSFHCGCEPGYQLKGRKCMDV 5231

Query: 2086 NECAENPGVCT-NGVCVNTDGSFRCE--CPFGYSLDFTGINCVDTDECSVG-HPCGQGT- 2140
            NEC +N  VC  +  C NT G ++C   CP G +    G  C+D DEC  G H C     
Sbjct: 5232 NECRQN--VCRPDQHCKNTRGGYKCIDLCPNGMTKAENG-TCIDIDECKDGTHQCRYNQI 5288

Query: 2141 CTNVIGGFECACADGFEP-GLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLR 2199
            C N  G + C C  G+   G+   C DI+EC   P  CA +C NT GS+ C CP G  L 
Sbjct: 5289 CENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLL 5348

Query: 2200 EDGAMCRDVDECAD-GQQ--------------------------DCHARGMECKN----- 2227
             DG  C  ++   + G Q                            ++   E +N     
Sbjct: 5349 GDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSL 5408

Query: 2228 --LIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQP 2285
                 T    CP G      S + C D +EC    D C +  C NT GS++C C  G+Q 
Sbjct: 5409 SRTRRTIRKTCPEGSE---ASHDTCVDIDECE-NTDACQH-ECKNTFGSYQCICPPGYQL 5463

Query: 2286 SPTLTECHDI 2295
            +     C DI
Sbjct: 5464 THNGKTCQDI 5473



 Score =  139 bits (349), Expect = 5e-32
 Identities = 118/399 (29%), Positives = 161/399 (40%), Gaps = 48/399 (12%)

Query: 551  GSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRV 610
            G  S  C  GF L   G +C D DEC     C +  C N  G++ C C  GL +  DGR 
Sbjct: 5086 GDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADGRT 5144

Query: 611  CVDTHV----RSTCYGAIEKGS----------CARPFPGTVTKSECCCANPDHGFGEPCQ 656
            C D       R TC+   +  +          C   F  T     C   N +     PC 
Sbjct: 5145 CQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDIN-ECQESSPCH 5203

Query: 657  LCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVC-ANGVCENLRGSYRCV--CN 710
                     F   C  G  +   GR   D+NEC     VC  +  C+N RG Y+C+  C 
Sbjct: 5204 QRCFNAIGSFHCGCEPGYQL--KGRKCMDVNECR--QNVCRPDQHCKNTRGGYKCIDLCP 5259

Query: 711  LGYEAGASGKDCTDVDECALNSLLCD-NGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDE 769
             G     +G  C D+DEC   +  C  N  C+N+ GSY C CP G+        C D++E
Sbjct: 5260 NGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINE 5318

Query: 770  C--LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTK----GTCWLKIQESRC-- 821
            C  +  PC +  C N  GS+ C C PG  L   G  C    +    GT +     +R   
Sbjct: 5319 CEQVPKPC-AHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSP 5377

Query: 822  --------EVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNEC 873
                    +   Q + L S       +       R  I   C  G +  +  TC D++EC
Sbjct: 5378 VRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEG-SEASHDTCVDIDEC 5436

Query: 874  ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDV 912
            E+    C +  C NT GS++C CP G  L  +G+ C D+
Sbjct: 5437 EN-TDACQH-ECKNTFGSYQCICPPGYQLTHNGKTCQDI 5473



 Score =  115 bits (289), Expect = 5e-25
 Identities = 60/148 (40%), Positives = 74/148 (50%), Gaps = 4/148 (2%)

Query: 2501 HCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQH 2560
            H   + G    +C  GFTL S G  C D +EC   + C H C N +G Y CSCP+G T  
Sbjct: 5080 HASISKGDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIA 5139

Query: 2561 SQWAQCVDENECALSPPTC-GSASCRNTLGGFRCV--CPSGFDFDQALGGCQEVDECAGR 2617
            +    C D +ECAL   TC     C NT+G +RCV  C SGF        CQ+++EC   
Sbjct: 5140 ADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ-E 5198

Query: 2618 RGPCSYSCANTPGGFLCGCPQGYFRAGQ 2645
              PC   C N  G F CGC  GY   G+
Sbjct: 5199 SSPCHQRCFNAIGSFHCGCEPGYQLKGR 5226



 Score =  115 bits (287), Expect = 8e-25
 Identities = 106/398 (26%), Positives = 154/398 (38%), Gaps = 86/398 (21%)

Query: 407  QTIDICRHFTNLCLNGR-CLPTPSSYRC--ECNVGYTQDVRG-ECIDVDECT-SSPCHHG 461
            Q ID C    + C  G+ C  T  SYRC   C  G+ +   G  C D++EC  SSPCH  
Sbjct: 5146 QDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQR 5205

Query: 462  DCVNIPGTYHCRCYPGFQ--------ATPTRQ---------------------------- 485
             C N  G++HC C PG+Q            RQ                            
Sbjct: 5206 -CFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTK 5264

Query: 486  ----ACVDVDECIVSGGLCHLGR-CVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 540
                 C+D+DEC      C   + C NT GS++CVC  G+     G+ C+D NEC     
Sbjct: 5265 AENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPK 5324

Query: 541  CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH----CTNTEGSFRC 596
                 C N  GSF C+C PG  L   G  C  ++     G   + +     +    +++ 
Sbjct: 5325 PCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQP 5384

Query: 597  Q--------CLGGLAVGTDGRVCVD---THVRSTCYGAIEKGSCARPFPGTVTKSECCCA 645
            Q             +   + R  +      +R TC              G+    + C  
Sbjct: 5385 QQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCP------------EGSEASHDTCVD 5432

Query: 646  NPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCA-NGVCENL 701
              +    + CQ         +Q +C  G  +T +G+   DI+EC      C  N +C N+
Sbjct: 5433 IDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNM 5492

Query: 702  RGSYRCV---CNLGYE----AGASGKDCTDVD-ECALN 731
            RGSY+C+   C   Y+    +G   K+C   D ECAL+
Sbjct: 5493 RGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALS 5530



 Score = 85.1 bits (209), Expect = 9e-16
 Identities = 98/389 (25%), Positives = 144/389 (37%), Gaps = 85/389 (21%)

Query: 232  CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA----- 286
            C  GF       +CQD++ECQ      Q   C N +GSFHC C  G++L           
Sbjct: 5177 CGSGFRRTSDGLSCQDINECQESSPCHQ--RCFNAIGSFHCGCEPGYQLKGRKCMDVNEC 5234

Query: 287  ----------CEDYRAG-ACFSVLFGG--------------------RCAGDLAGHYTRR 315
                      C++ R G  C  +   G                    +C  +     TR 
Sbjct: 5235 RQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRG 5294

Query: 316  --QCCCDRG-RCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG 372
              +C C RG R    G      P    NE +Q+           PG F  +   G + +G
Sbjct: 5295 SYRCVCPRGYRSQGVGR-----PCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLG 5349

Query: 373  PPLGPARLNPHGSDARGIPSLGPGNSNIGTATLN------QTIDICRHFTNLCL------ 420
                 A L         +P+ G   S+   A  +      Q     R +++L        
Sbjct: 5350 DGKSCAGLER-------LPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYR 5402

Query: 421  NGRCL--PTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGF 478
            N R     T  + R  C  G ++     C+D+DEC ++     +C N  G+Y C C PG+
Sbjct: 5403 NSRTSLSRTRRTIRKTCPEG-SEASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGY 5461

Query: 479  QATPTRQACVDVDECIVSGGLCHLGR-CVNTEGSFQCV---CNAGFELSPDG----KNCV 530
            Q T   + C D+DEC+     C   R C N  GS+QC+   C   ++  P      KNC 
Sbjct: 5462 QLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCP 5521

Query: 531  DHN-ECATSTMCVN--------GVCLNED 550
             ++ ECA S   +         G+  N+D
Sbjct: 5522 PNDLECALSPYALEYKLVSLPFGIATNQD 5550



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 121/455 (26%), Positives = 152/455 (33%), Gaps = 85/455 (18%)

Query: 90   CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNG-GTCRGASCLCQKGYTGTVCGQ 148
            C  GF        CAD      C    G+ CS SC N  GT     C C KG T    G+
Sbjct: 5092 CPSGFTLDSVGPFCAD---EDECAA--GNPCSHSCHNAMGTYY---CSCPKGLTIAADGR 5143

Query: 149  PICD--------RGCHNGGRC---IGPNRCA--CVYGFM----GPQCE---RDYRTGPC- 187
               D          CH G  C   IG  RC   C  GF     G  C+       + PC 
Sbjct: 5144 TCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCH 5203

Query: 188  ---FGQVGPE--GCQ--HQLTGLVCTKALCCAT---------VGRAWGLPC-ELCPAQPH 230
               F  +G    GC+  +QL G  C     C                G  C +LCP    
Sbjct: 5204 QRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCP---- 5259

Query: 231  PCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGHRLSDSSAACED 289
                  +     G C D+DEC+     C+    C N  GS+ C CP G+R       C D
Sbjct: 5260 ----NGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMD 5315

Query: 290  YRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGR--------CWAAGPVPELCPPRGSNE 341
                 C  V     CA   +      +C C  G+        C     +P       S  
Sbjct: 5316 --INECEQV--PKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYN 5371

Query: 342  FQQLCAQRLPLLP-GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNI 400
              +    R    P  H   +  L    S         +R        R I    P  S  
Sbjct: 5372 LARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTR------RTIRKTCPEGSEA 5425

Query: 401  GTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCH 459
               T    ID C + T+ C +  C  T  SY+C C  GY     G+ C D+DEC     H
Sbjct: 5426 SHDTC-VDIDECEN-TDACQH-ECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVH 5482

Query: 460  HGD---CVNIPGTYHC---RCYPGFQATPTRQACV 488
             G    C N+ G+Y C    C P +Q  P    C+
Sbjct: 5483 CGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCL 5517



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 62/240 (25%), Positives = 81/240 (33%), Gaps = 44/240 (18%)

Query: 86   CRRACGEGFCSQPN-LCTCADGTLAPS---CGVSRGSGCSVSCMNGGTCRGASCL--CQK 139
            C  A G  +CS P  L   ADG        C + R + C        T     C+  C  
Sbjct: 5121 CHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHT-CHAGQDCDNTIGSYRCVVRCGS 5179

Query: 140  GYTGTVCGQPICD-RGCHNGGRC-------IGPNRCACVYGFM--GPQCE--RDYRTGPC 187
            G+  T  G    D   C     C       IG   C C  G+   G +C    + R   C
Sbjct: 5180 GFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVC 5239

Query: 188  FGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPC---ELCPAQPHPCR----------- 233
                  + C++   G  C   LC   + +A    C   + C    H CR           
Sbjct: 5240 RPD---QHCKNTRGGYKCID-LCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGS 5295

Query: 234  ------RGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287
                  RG+        C D++EC+ VP  C    C N  GSF C CP G  L     +C
Sbjct: 5296 YRCVCPRGYRSQGVGRPCMDINECEQVPKPC-AHQCSNTPGSFKCICPPGQHLLGDGKSC 5354


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  235 bits (600), Expect = 4e-61
 Identities = 145/405 (35%), Positives = 191/405 (47%), Gaps = 30/405 (7%)

Query: 985  KDVNECKVFPGLC-THGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGT 1043
            +DV+EC      C     C+NT  S+ C C  G+  D   ++C D+DEC    +      
Sbjct: 28   QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG--KHCKDVDECEREDNAGCVHD 85

Query: 1044 CVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHE 1103
            CVN PG++ C C+ G+        NC+DVDECA     C+  +C N  GSY+C C  G  
Sbjct: 86   CVNIPGNYRCTCYDGFHLAHD-GHNCLDVDECAEGNGGCQ-QSCVNMMGSYECHCREGFF 143

Query: 1104 LTAKGTAC----EDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINEC 1159
            L+     C    E+   C   +  C H       G   C C  GF+ T +++ C     C
Sbjct: 144  LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTC 201

Query: 1160 RVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGH 1219
               NGGC   C +TE   RC C   + L  DG+ C  ++ C  N   CD   C +   G 
Sbjct: 202  NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCD-SKCHDAATGV 258

Query: 1220 RCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCS 1279
             C C  GFM  PD +TC D+DEC LN   C H  C NT GSF C C+ GY +      C 
Sbjct: 259  HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQ 317

Query: 1280 DVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGF-ECHDLDECVSQEHRCSPRGDC 1338
            D+DEC      CD    C+N PGSF C C  G++  G   C D+DEC      C  R  C
Sbjct: 318  DIDECSF-DRTCDH--ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGC 372

Query: 1339 LNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPG 1383
            +N PGSY+CTC    AG G    +  +C E +      +C  +PG
Sbjct: 373  INTPGSYQCTCP---AGQGRLHWNGKDCTEPL------KCQGSPG 408



 Score =  218 bits (555), Expect = 7e-56
 Identities = 131/373 (35%), Positives = 177/373 (47%), Gaps = 24/373 (6%)

Query: 1110 ACEDIDECSLSDGLCP-HGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINEC-RVQNGGCD 1167
            A +D+DEC      C     C N   +++C C +G+  T D + C D++EC R  N GC 
Sbjct: 26   AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCV 83

Query: 1168 VHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGF 1227
              C+N  G+YRC+C  G+ L  DG  C DVDEC E    C Q  C NM G + C C +GF
Sbjct: 84   HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGF 142

Query: 1228 MATPDMRTCVDVDECDLN----PHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
              + +  TC+   E  +N     H C H   E  KG   C C+ G+ + K    C     
Sbjct: 143  FLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT-- 200

Query: 1284 CEVGGHNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNV 1341
            C  G   C    +C +      C C   +V   DG  C  ++ C      C  +  C + 
Sbjct: 201  CNYGNGGCQH--TCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSK--CHDA 254

Query: 1342 PGSYRCTCRQGFA--GDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDH 1399
                 CTC  GF    D   C+D DEC  N   CD+  C N  G + C C+ G+    + 
Sbjct: 255  ATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINE 313

Query: 1400 RACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGV 1459
            R CQD+DEC+    C    C N PG F+C+C+ GY L  G  +C D++EC+         
Sbjct: 314  RNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCRFG 371

Query: 1460 CINTPGSYLCSCP 1472
            CINTPGSY C+CP
Sbjct: 372  CINTPGSYQCTCP 384



 Score =  206 bits (525), Expect = 2e-52
 Identities = 229/829 (27%), Positives = 307/829 (37%), Gaps = 124/829 (14%)

Query: 407  QTIDICRHFTNLC-LNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC---TSSPCHHGD 462
            Q +D C   T+ C ++  C  TP SY+C C  GYT D +  C DVDEC    ++ C H D
Sbjct: 28   QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK-HCKDVDECEREDNAGCVH-D 85

Query: 463  CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
            CVNIPG Y C CY GF        C+DVDEC    G C    CVN  GS++C C  GF L
Sbjct: 86   CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFL 144

Query: 523  SPDGKNCVDHNECATSTMCVNGVCLN-----EDGSFSCLCKPGFLLAPGGHYCMDIDECQ 577
            S +   C+   E   + M  N  C +       G  +C C+PGF L      C     C 
Sbjct: 145  SDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTCN 202

Query: 578  TPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTV 637
                     C +TE   RC C     + TDG+ C++     TC  A+  G C        
Sbjct: 203  YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE-----TC--AVNNGGCDSKCHDAA 255

Query: 638  TKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGV 697
            T   C C     GF     L P + +                 +DI+EC L+   C + +
Sbjct: 256  TGVHCTC---PVGF----MLQPDRKTC----------------KDIDECRLNNGGC-DHI 291

Query: 698  CENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHF 757
            C N  GS+ C C  GY+   + ++C D+DEC+ +   CD+  C N+PGS+ C C  G+  
Sbjct: 292  CRNTVGSFECSCKKGYKLLINERNCQDIDECSFDR-TCDH-ICVNTPGSFQCLCHRGYLL 349

Query: 758  WQDTEICKDVDECL--SSPCVSGVCRNLAGSYTCKCGPG-SRLDPSGTFCLDSTKGTCWL 814
            +  T  C DVDEC      C  G C N  GSY C C  G  RL  +G  C +  K  C  
Sbjct: 350  YGITH-CGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPLK--CQG 405

Query: 815  KIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECE 874
                S+  ++   +  +  C  T  +       R    P    GF     V+C   +   
Sbjct: 406  SPGASKAMLSCNRSGKKDTCALTCPS-------RARFLPESENGFT----VSCGTPSPRA 454

Query: 875  SFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFL----RWDEDECG-VT 929
            +      NG   N+       C E  +L    R    ++   C L    +   +E G +T
Sbjct: 455  APARAGHNGNSTNSN-----HCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRIT 509

Query: 930  LPGKYRMDVC--------CCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGR 981
             PG      C        C S     G      P  E           +         G 
Sbjct: 510  GPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGL 569

Query: 982  PFYKDVNECKVFPGLCTHGTCRN------TVGSFHCACAGGFALDAQERNCTDIDECRIS 1035
            P  +   E ++   L       N       +       A    L A ER    ++ CR  
Sbjct: 570  PCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGER-AEPMESCRPG 628

Query: 1036 PDLCGQGTCVNTP------GSFECECFPGYESGFMLMKNCMDVDEC----ARDPLLCRGG 1085
                G   CV+ P      G  E +C P     F   +  +  D C    A  PL   G 
Sbjct: 629  QHRAGT-KCVSCPQGTYYHGQTE-QCVPCPAGTFQEREGQLSCDLCPGSDAHGPL---GA 683

Query: 1086 TCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQC-SCHAGF 1144
            T   T      QCPPG         C+           CP G      G   C  C  G 
Sbjct: 684  TNVTTCAG---QCPPGQHSVDGFKPCQP----------CPRGTYQPEAGRTLCFPCGGGL 730

Query: 1145 QSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRC-SCGQGYSLMPDGR 1192
              T   +G +   +C  +      H  NT   +RC  C  G S  PD R
Sbjct: 731  --TTKHEGAISFQDCDTKVQCSPGHYYNT-SIHRCIRCAMG-SYQPDFR 775



 Score =  197 bits (500), Expect = 2e-49
 Identities = 147/437 (33%), Positives = 187/437 (42%), Gaps = 53/437 (12%)

Query: 1847 DIDEC--DRQPCG-NGTCKNIIGSYNCLCFPGFVVTHNGD-CVDFDECTTLVGQVCRFGH 1902
            D+DEC      C  +  C+N   SY C+C  G+  T +G  C D DEC       C    
Sbjct: 29   DVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC-VHD 85

Query: 1903 CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQV 1962
            C+N  G++ C C DGF L  DG NC+D +EC    G C   +C N+ GS+ C C  GF +
Sbjct: 86   CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC-QQSCVNMMGSYECHCREGFFL 144

Query: 1963 QSDH--CIDIDE----CSEEPNLCLFGTCTNSP-GSFQCLCPPGFVLSDN---------- 2005
              +   CI   E    C  + + C    C  +P G   C C PGF L+ N          
Sbjct: 145  SDNQHTCIQRPEEGMNCMNKNHGCAH-ICRETPKGGIACECRPGFELTKNQRDCKLTCNY 203

Query: 2006 -----GHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRC--CCSKRPGEGWGDPCELCPQ 2058
                  H C DT Q           C +    +T    C   C+   G      C+    
Sbjct: 204  GNGGCQHTCDDTEQG------PRCGCHIKFVLHTDGKTCIETCAVNNG-----GCDSKCH 252

Query: 2059 EGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD 2118
            + +      CP G    P     + D++EC  N G C + +C NT GSF C C  GY L 
Sbjct: 253  DAATGVHCTCPVGFMLQPDRKTCK-DIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLL 310

Query: 2119 FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCA 2178
                NC D DECS    C    C N  G F+C C  G+    +  C D+DECS+N   C 
Sbjct: 311  INERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCR 369

Query: 2179 FRCHNTEGSYLCTCPAGY-TLREDGAMCRDVDECADGQQDCHARGMECKNLIG---TFAC 2234
            F C NT GSY CTCPAG   L  +G  C +  +C  G        + C N  G   T A 
Sbjct: 370  FGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPGASKAMLSC-NRSGKKDTCAL 427

Query: 2235 VCPPGMRPLPGSGEGCT 2251
             CP   R LP S  G T
Sbjct: 428  TCPSRARFLPESENGFT 444



 Score =  193 bits (491), Expect = 2e-48
 Identities = 147/452 (32%), Positives = 190/452 (42%), Gaps = 88/452 (19%)

Query: 869  DVNECESFPGVCP-NGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECG 927
            DV+EC      C  +  C NT  S++C C  G   D  G+ C DV  + C     ED  G
Sbjct: 29   DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGD--GKHCKDV--DECER---EDNAG 81

Query: 928  -----VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRP 982
                 V +PG YR   C C  G     +   C                            
Sbjct: 82   CVHDCVNIPGNYR---CTCYDGFHLAHDGHNC---------------------------- 110

Query: 983  FYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDE----CRISPDL 1038
               DV+EC    G C   +C N +GS+ C C  GF L   +  C    E    C      
Sbjct: 111  --LDVDECAEGNGGCQQ-SCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHG 167

Query: 1039 CGQGTCVNTP-GSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGG------TCTNTD 1091
            C    C  TP G   CEC PG+E    L KN  D        L C  G      TC +T+
Sbjct: 168  CAH-ICRETPKGGIACECRPGFE----LTKNQRDCK------LTCNYGNGGCQHTCDDTE 216

Query: 1092 GSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQ 1151
               +C C     L   G  C  I+ C++++G C   +C +      C+C  GF   PDR+
Sbjct: 217  QGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCD-SKCHDAATGVHCTCPVGFMLQPDRK 273

Query: 1152 GCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH 1211
             C DI+ECR+ NGGCD  C NT GS+ CSC +GY L+ + R C D+DEC  + R CD   
Sbjct: 274  TCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFD-RTCDH-I 331

Query: 1212 CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMV 1271
            C N PG  +CLC+ G++    +  C DVDEC +N   C  G C NT GS+ C C  G   
Sbjct: 332  CVNTPGSFQCLCHRGYLLY-GITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQ-- 387

Query: 1272 RKGATGCSDVDECEVGGHNCDSHASCLNIPGS 1303
                            G +C     C   PG+
Sbjct: 388  ----------GRLHWNGKDCTEPLKCQGSPGA 409



 Score =  189 bits (479), Expect = 4e-47
 Identities = 139/475 (29%), Positives = 204/475 (42%), Gaps = 77/475 (16%)

Query: 479 QATPTRQACVDVDECIVSGGLCHLGR-CVNTEGSFQCVCNAGFELSPDGKNCVDHNEC-- 535
           +A    +A  DVDEC+     CH+   C NT  S++C+C +G+  + DGK+C D +EC  
Sbjct: 19  RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECER 76

Query: 536 ATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFR 595
             +  CV+  C+N  G++ C C  GF LA  GH C+D+DEC          C N  GS+ 
Sbjct: 77  EDNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYE 135

Query: 596 CQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPC 655
           C C  G  +  +   C+                  RP  G        C N +HG    C
Sbjct: 136 CHCREGFFLSDNQHTCIQ-----------------RPEEG------MNCMNKNHGCAHIC 172

Query: 656 QLCPAKDSAEFQALCSSGLGITTDGRDIN-ECALDPEVCANGVCENLRGSYRCVCNLGYE 714
           +  P    A     C  G  +T + RD    C      C +  C++     RC C++ + 
Sbjct: 173 RETPKGGIA---CECRPGFELTKNQRDCKLTCNYGNGGCQH-TCDDTEQGPRCGCHIKFV 228

Query: 715 AGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSS 773
               GK C  ++ CA+N+  CD+  C ++     C+CP GF    D + CKD+DEC L++
Sbjct: 229 LHTDGKTC--IETCAVNNGGCDSK-CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNN 285

Query: 774 PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSE 833
                +CRN  GS+ C C  G +                 L I E  C+ ++   S    
Sbjct: 286 GGCDHICRNTVGSFECSCKKGYK-----------------LLINERNCQ-DIDECSFDRT 327

Query: 834 CCATLGAAWGSPCERCEIDPACARGFARMTGVT-CDDVNECESFPGVCPNGRCVNTAGSF 892
           C        GS          C RG+  + G+T C DV+EC    G C  G C+NT GS+
Sbjct: 328 CDHICVNTPGS------FQCLCHRGYL-LYGITHCGDVDECSINRGGCRFG-CINTPGSY 379

Query: 893 RCECPEGL-MLDASGRLCVD-----------VRLEPCFLRWDEDECGVTLPGKYR 935
           +C CP G   L  +G+ C +             +  C     +D C +T P + R
Sbjct: 380 QCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRAR 434



 Score =  186 bits (473), Expect = 2e-46
 Identities = 130/434 (29%), Positives = 183/434 (42%), Gaps = 75/434 (17%)

Query: 2346 AYRKLCPHGSGYTAEGR---DVDECRMLAHL-CAHGECINSLGSFRCHCQAGYTPDATAT 2401
            +Y+ +C   SGYT +G+   DVDEC    +  C H +C+N  G++RC C  G+       
Sbjct: 52   SYKCICK--SGYTGDGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGH 108

Query: 2402 TCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDE----CTSRQHNC 2457
             CLD+DEC++    C   C N  GS+ C C  G+ L ++  TC    E    C ++ H C
Sbjct: 109  NCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC 168

Query: 2458 QFLCVNT-VGAFTCRCPPGF--TQHHQAC-----FDNDEC-----SAQPGP-CGAH---- 2499
              +C  T  G   C C PGF  T++ + C     + N  C       + GP CG H    
Sbjct: 169  AHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFV 228

Query: 2500 --------------------GHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRC 2538
                                  CH+      C C  GF L      C+D++EC      C
Sbjct: 229  LHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC 288

Query: 2539 QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG 2598
             H C+N +G + CSC +G+        C D +EC+    TC    C NT G F+C+C  G
Sbjct: 289  DHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFD-RTCDHI-CVNTPGSFQCLCHRG 346

Query: 2599 FDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQG--------HCVS 2650
            +     +  C +VDEC+  RG C + C NTPG + C CP G  R             C  
Sbjct: 347  Y-LLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQG 405

Query: 2651 GLGFS--------PGPQDT-----PDKEELL-SSEACYECKINGLSPRDRPRRSAHRDHQ 2696
              G S         G +DT     P +   L  SE  +       SPR  P R+ H  + 
Sbjct: 406  SPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNS 465

Query: 2697 VNLATLDSEALLTL 2710
             N       A+L++
Sbjct: 466  TNSNHCHEAAVLSI 479



 Score =  182 bits (462), Expect = 4e-45
 Identities = 128/420 (30%), Positives = 181/420 (43%), Gaps = 44/420 (10%)

Query: 2206 RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVN 2265
            +DVDEC +G  +CH   + C+N   ++ C+C  G     G G+ C D +EC  + +    
Sbjct: 28   QDVDECVEGTDNCHIDAI-CQNTPRSYKCICKSGYT---GDGKHCKDVDECEREDNAGCV 83

Query: 2266 GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC 2325
              CVN  G++RC C +GF  +     C D+ +        Q  C ++  S       EC 
Sbjct: 84   HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGS------YECH 137

Query: 2326 CGGGRGWGPRCELC---PLPGTSAYRKL--CPHGSGYTAEGRDVDECRMLAHL------- 2373
            C  G         C   P  G +   K   C H    T +G    ECR    L       
Sbjct: 138  CREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197

Query: 2374 ---CAHGE------CINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTK 2424
               C +G       C ++    RC C   +       TC+  + C+     C   C +  
Sbjct: 198  KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI--ETCAVNNGGCDSKCHDAA 255

Query: 2425 GSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ--HHQA 2482
                C+CP G++L+ D +TCKD+DEC      C  +C NTVG+F C C  G+    + + 
Sbjct: 256  TGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERN 315

Query: 2483 CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHG 2541
            C D DECS           C NTPGSF+C CH+G+ L    H C DV+EC      C+ G
Sbjct: 316  CQDIDECSFDR---TCDHICVNTPGSFQCLCHRGYLLYGITH-CGDVDECSINRGGCRFG 371

Query: 2542 CQNQLGGYRCSCPQGFTQ-HSQWAQCVDENECALSP-PTCGSASCRNTLGGFRC--VCPS 2597
            C N  G Y+C+CP G  + H     C +  +C  SP  +    SC  +     C   CPS
Sbjct: 372  CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPS 431



 Score =  180 bits (456), Expect = 2e-44
 Identities = 115/389 (29%), Positives = 160/389 (41%), Gaps = 59/389 (15%)

Query: 1925 KNCVDTNECLSLAGTC-LPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFG 1983
            K   D +EC+     C +   CQN   S++CIC  G+     HC D+DEC  E N     
Sbjct: 25   KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVH 84

Query: 1984 TCTNSPGSFQCLCPPGFVLSDNGHRCFDTR---------QSFCFTRFEAGKCSVPKAFNT 2034
             C N PG+++C C  GF L+ +GH C D           Q  C     + +C   + F  
Sbjct: 85   DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFL 144

Query: 2035 TKTRCCCSKRPGEGW-------------------GDPCELCP----QEGSAAFQELCPFG 2071
            +  +  C +RP EG                    G  CE  P     +     +  C +G
Sbjct: 145  SDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYG 204

Query: 2072 HGAV--------PGP-----------DDSREDVNECAENPGVCTNGVCVNTDGSFRCECP 2112
            +G           GP            D +  +  CA N G C +  C +      C CP
Sbjct: 205  NGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGC-DSKCHDAATGVHCTCP 263

Query: 2113 FGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECS 2171
             G+ L      C D DEC + +      C N +G FEC+C  G++  +    C+DIDECS
Sbjct: 264  VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECS 323

Query: 2172 LNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGT 2231
             +   C   C NT GS+ C C  GY L      C DVDEC+  +  C      C N  G+
Sbjct: 324  FD-RTCDHICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCR---FGCINTPGS 378

Query: 2232 FACVCPPGMRPLPGSGEGCTDDNECHAQP 2260
            + C CP G   L  +G+ CT+  +C   P
Sbjct: 379  YQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407



 Score =  172 bits (437), Expect = 3e-42
 Identities = 142/429 (33%), Positives = 188/429 (43%), Gaps = 73/429 (17%)

Query: 1721 DIDECGEIPAIC-ANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNAD 1779
            D+DEC E    C  + IC N   S++C C +G+  +     C+DVDEC  RE       D
Sbjct: 29   DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG--KHCKDVDEC-EREDNAGCVHD 85

Query: 1780 CINIPGSYRCKCTRGYKLS-PGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA 1838
            C+NIPG+YRC C  G+ L+  G  C+  +EC E    C    C++  GSY C C  GF  
Sbjct: 86   CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SCVNMMGSYECHCREGFFL 144

Query: 1839 SADQTLCMDIDECDRQPCGNGT--CKNII-----GSYNCLCFPGFVVTHN-GDCVDFDEC 1890
            S +Q  C+   E +   C N    C +I      G   C C PGF +T N  DC      
Sbjct: 145  SDNQHTCIQRPE-EGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC------ 197

Query: 1891 TTLVGQVCRFGH------CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGT 1944
                   C +G+      C +T     C C   F L  DGK C++T  C    G C    
Sbjct: 198  ----KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGC-DSK 250

Query: 1945 CQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVL 2002
            C +      C CP GF +Q D   C DIDEC      C    C N+ GSF+C C  G+ L
Sbjct: 251  CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSCKKGYKL 309

Query: 2003 SDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSA 2062
              N   C D             +CS    F+ T    C +  PG                
Sbjct: 310  LINERNCQD-----------IDECS----FDRTCDHICVN-TPG---------------- 337

Query: 2063 AFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYS-LDFTG 2121
            +FQ LC  G+  + G      DV+EC+ N G C  G C+NT GS++C CP G   L + G
Sbjct: 338  SFQCLCHRGY-LLYGITHC-GDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNG 394

Query: 2122 INCVDTDEC 2130
             +C +  +C
Sbjct: 395  KDCTEPLKC 403



 Score =  167 bits (423), Expect = 1e-40
 Identities = 108/334 (32%), Positives = 150/334 (44%), Gaps = 57/334 (17%)

Query: 1192 RACADVDECEENPRVCD-QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHI-C 1249
            +A  DVDEC E    C     C N P  ++C+C  G+  T D + C DVDEC+   +  C
Sbjct: 25   KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC 82

Query: 1250 LHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCL 1309
            +H DC N  G++ C C  G+ +      C DVDEC  G   C    SC+N+ GS+ C C 
Sbjct: 83   VH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ--SCVNMMGSYECHCR 139

Query: 1310 PGWV--GDGFECHDLDE----CVSQEHRCSPRGDCLNVP-GSYRCTCRQGFA-------- 1354
             G+    +   C    E    C+++ H C+    C   P G   C CR GF         
Sbjct: 140  EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHI--CRETPKGGIACECRPGFELTKNQRDC 197

Query: 1355 ------GDG---FFCEDRDE----------------------CAENVDLCDNGQCLNAPG 1383
                  G+G     C+D ++                      CA N   CD+ +C +A  
Sbjct: 198  KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDS-KCHDAAT 256

Query: 1384 GYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNC 1443
            G  C C +GF    D + C+D+DEC   N      C N  G F C C  GY+L     NC
Sbjct: 257  GVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNC 316

Query: 1444 TDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477
             DI+EC+    C + +C+NTPGS+ C C + + L
Sbjct: 317  QDIDECSFDRTC-DHICVNTPGSFQCLCHRGYLL 349



 Score =  166 bits (421), Expect = 2e-40
 Identities = 123/408 (30%), Positives = 172/408 (42%), Gaps = 66/408 (16%)

Query: 1361 EDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECA-QGNLCAFGS 1418
            +D DEC E  D C  +  C N P  Y+C C+ G+  T D + C+DVDEC  + N      
Sbjct: 28   QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHD 85

Query: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELN 1478
            C N+PG +RC C  G+ L   G NC D++ECA+        C+N  GSY C C + F L+
Sbjct: 86   CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLS 145

Query: 1479 PSGVGCVD--TRAGNCFLETH-------DRGDSGISCSAEIGVGVTRASCCCSLGRAWGN 1529
             +   C+       NC  + H       +    GI+C    G  +T+    C L   +GN
Sbjct: 146  DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGN 205

Query: 1530 -PCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGG---DCVNTFGS 1585
              C+     + TE    C     F      V+  D   C E   +  GG    C +    
Sbjct: 206  GGCQ--HTCDDTEQGPRCGCHIKF------VLHTDGKTCIETCAVNNGGCDSKCHDAATG 257

Query: 1586 FQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNC 1645
              C CP G+ L    + C+DIDEC  ++G C    C NT+G++ C C   Y  +    NC
Sbjct: 258  VHCTCPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSCKKGYKLLINERNC 316

Query: 1646 MDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGN 1705
             D+ +                         CS+      +R C+         +Q LC  
Sbjct: 317  QDIDE-------------------------CSF------DRTCDHICVNTPGSFQCLCHR 345

Query: 1706 QAPGFLT--DIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAG 1751
               G+L     H G   D+DEC      C  G CIN  GS++C CPAG
Sbjct: 346  ---GYLLYGITHCG---DVDECSINRGGCRFG-CINTPGSYQCTCPAG 386



 Score =  144 bits (364), Expect = 9e-34
 Identities = 113/393 (28%), Positives = 162/393 (41%), Gaps = 28/393 (7%)

Query: 1562 EDIDECQELPGLCQ-GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1620
            +D+DEC E    C     C NT  S++C C  GY  +   + C+D+DEC           
Sbjct: 28   QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHD 85

Query: 1621 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCC---- 1676
            C N  GNY C C   +   + G+NC+D+ +       NG CQ      +    C C    
Sbjct: 86   CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECA---EGNGGCQQSCVNMMGSYECHCREGF 142

Query: 1677 --SYNIGQAWNRPCEA--CPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG-EIPAI 1731
              S N      RP E   C         I       G   +   G  L  ++   ++   
Sbjct: 143  FLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCN 202

Query: 1732 CANGICINQIGSF----RCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSY 1787
              NG C +         RC C   F  ++    C  ++ C      C  ++ C +     
Sbjct: 203  YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGC--DSKCHDAATGV 258

Query: 1788 RCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCM 1846
             C C  G+ L P    C   +ECR     C H  C +T GS+ C C +G++   ++  C 
Sbjct: 259  HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQ 317

Query: 1847 DIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNT 1906
            DIDEC      +  C N  GS+ CLC  G+++     C D DEC+   G  CRFG C+NT
Sbjct: 318  DIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGG-CRFG-CINT 375

Query: 1907 AGSFHCLCQDG-FELTADGKNCVDTNECLSLAG 1938
             GS+ C C  G   L  +GK+C +  +C    G
Sbjct: 376  PGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPG 408



 Score =  133 bits (335), Expect = 2e-30
 Identities = 112/368 (30%), Positives = 149/368 (40%), Gaps = 60/368 (16%)

Query: 245 CQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRC 304
           C+DVDEC+          CVN+ G++ C C  G  L+     C D    A       G C
Sbjct: 68  CKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECA----EGNGGC 123

Query: 305 AGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLL 364
                      +C C  G                 ++ Q  C QR    P          
Sbjct: 124 QQSCVNMMGSYECHCREGFF--------------LSDNQHTCIQR----PEE-------- 157

Query: 365 GFGSNGMGPPLGPA---RLNPHGSDARGIPSLGPG-----NSNIGTATLNQTIDICRHFT 416
             G N M    G A   R  P G  A       PG     N      T N     C+H  
Sbjct: 158 --GMNCMNKNHGCAHICRETPKGGIA---CECRPGFELTKNQRDCKLTCNYGNGGCQH-- 210

Query: 417 NLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGDCVNIPGTYHCRCY 475
                  C  T    RC C++ +     G+ CI+     +  C    C +     HC C 
Sbjct: 211 ------TCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGC-DSKCHDAATGVHCTCP 263

Query: 476 PGFQATPTRQACVDVDECIVSGGLC-HLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNE 534
            GF   P R+ C D+DEC ++ G C H+  C NT GSF+C C  G++L  + +NC D +E
Sbjct: 264 VGFMLQPDRKTCKDIDECRLNNGGCDHI--CRNTVGSFECSCKKGYKLLINERNCQDIDE 321

Query: 535 CATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ-TPGICVNGHCTNTEGS 593
           C+    C + +C+N  GSF CLC  G+LL  G  +C D+DEC    G C  G C NT GS
Sbjct: 322 CSFDRTC-DHICVNTPGSFQCLCHRGYLLY-GITHCGDVDECSINRGGCRFG-CINTPGS 378

Query: 594 FRCQCLGG 601
           ++C C  G
Sbjct: 379 YQCTCPAG 386



 Score =  128 bits (322), Expect = 7e-29
 Identities = 67/202 (33%), Positives = 90/202 (44%), Gaps = 10/202 (4%)

Query: 2442 RTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAH 2499
            +  +D+DEC     NC    +C NT  ++ C C  G+T   + C D DEC  +    G  
Sbjct: 25   KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDN-AGCV 83

Query: 2500 GHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHGCQNQLGGYRCSCPQGFT 2558
              C N PG++RC C+ GF L   GH C DV+EC +G   CQ  C N +G Y C C +GF 
Sbjct: 84   HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFF 143

Query: 2559 QHSQWAQCVDENE----CALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC 2614
                   C+   E    C      C         GG  C C  GF+  +    C+    C
Sbjct: 144  LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--C 201

Query: 2615 AGRRGPCSYSCANTPGGFLCGC 2636
                G C ++C +T  G  CGC
Sbjct: 202  NYGNGGCQHTCDDTEQGPRCGC 223



 Score =  106 bits (264), Expect = 4e-22
 Identities = 59/170 (34%), Positives = 77/170 (45%), Gaps = 10/170 (5%)

Query: 2478 QHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHR 2537
            Q+ +A  D DEC      C     C NTP S++C C  G+T    G  C+DV+EC+    
Sbjct: 22   QYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDN 79

Query: 2538 --CQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVC 2595
              C H C N  G YRC+C  GF        C+D +ECA     C   SC N +G + C C
Sbjct: 80   AGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC-QQSCVNMMGSYECHC 138

Query: 2596 PSGFDFDQALGGC----QEVDECAGRRGPCSYSCANTP-GGFLCGCPQGY 2640
              GF        C    +E   C  +   C++ C  TP GG  C C  G+
Sbjct: 139  REGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGF 188



 Score = 58.9 bits (141), Expect = 7e-08
 Identities = 72/298 (24%), Positives = 96/298 (32%), Gaps = 60/298 (20%)

Query: 60  CGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSG 119
           C    +A C       PG  +C        C +GF    +   C D      C    G G
Sbjct: 74  CEREDNAGCVHDCVNIPGNYRCT-------CYDGFHLAHDGHNCLD---VDECAEGNG-G 122

Query: 120 CSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNR------------- 166
           C  SC+N        C C++G+  +   Q  C +    G  C+  N              
Sbjct: 123 CQQSCVN--MMGSYECHCREGFFLSD-NQHTCIQRPEEGMNCMNKNHGCAHICRETPKGG 179

Query: 167 --CACVYGFMGPQCERDYRTGPCFGQVGPEGCQH-------------------QLTGLVC 205
             C C  GF   + +RD +    +G     GCQH                      G  C
Sbjct: 180 IACECRPGFELTKNQRDCKLTCNYGN---GGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC 236

Query: 206 TKALCCATVGRAWGLPCELCPAQPH-PCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCV 264
            +   CA         C       H  C  GF+       C+D+DEC+   G C    C 
Sbjct: 237 IET--CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICR 293

Query: 265 NMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG 322
           N VGSF C C  G++L  +   C+D          F   C           QC C RG
Sbjct: 294 NTVGSFECSCKKGYKLLINERNCQDID-----ECSFDRTCDHICVNTPGSFQCLCHRG 346



 Score = 52.0 bits (123), Expect = 8e-06
 Identities = 65/250 (26%), Positives = 88/250 (35%), Gaps = 71/250 (28%)

Query: 86  CRRAC--GEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCM---NGGTCRGASCLCQKG 140
           C+  C  G G C      TC D    P CG      C +  +   +G TC     +   G
Sbjct: 197 CKLTCNYGNGGCQH----TCDDTEQGPRCG------CHIKFVLHTDGKTCIETCAVNNGG 246

Query: 141 YTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQ--VGPEGCQH 198
                     CD  CH+    +    C C  GFM    + D +T     +  +   GC H
Sbjct: 247 ----------CDSKCHDAATGV---HCTCPVGFM---LQPDRKTCKDIDECRLNNGGCDH 290

Query: 199 QLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLC 258
                     +C  TVG      C         C++G+   I+   CQD+DEC +    C
Sbjct: 291 ----------ICRNTVG---SFECS--------CKKGYKLLINERNCQDIDEC-SFDRTC 328

Query: 259 QGGSCVNMVGSFHCRCPVGHRLSDSSAA-----CEDYRAGACFSVLFGGRCAGDLAGHYT 313
               CVN  GSF C C  G+ L   +       C   R G  F  +       +  G Y 
Sbjct: 329 DH-ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCI-------NTPGSY- 379

Query: 314 RRQCCCDRGR 323
             QC C  G+
Sbjct: 380 --QCTCPAGQ 387



 Score = 37.4 bits (85), Expect = 0.21
 Identities = 51/175 (29%), Positives = 66/175 (37%), Gaps = 31/175 (17%)

Query: 2522 SGHGCEDVNEC-DGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2580
            +G   E +  C  G HR    C         SCPQG   H Q  QCV           C 
Sbjct: 615  AGERAEPMESCRPGQHRAGTKC--------VSCPQGTYYHGQTEQCV----------PCP 656

Query: 2581 SASCRNTLGGFRC-VCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLC-GCPQ 2638
            + + +   G   C +CP G D    L G   V  CAG+  P  +S     G   C  CP+
Sbjct: 657  AGTFQEREGQLSCDLCP-GSDAHGPL-GATNVTTCAGQCPPGQHS---VDGFKPCQPCPR 711

Query: 2639 GYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHR 2693
            G ++   G     L F  G   T   E  +S + C + K+   SP      S HR
Sbjct: 712  GTYQPEAGRT---LCFPCGGGLTTKHEGAISFQDC-DTKVQ-CSPGHYYNTSIHR 761



 Score = 33.1 bits (74), Expect = 4.0
 Identities = 17/42 (40%), Positives = 20/42 (47%), Gaps = 3/42 (7%)

Query: 2609 QEVDECAGRRGPCSYS--CANTPGGFLCGCPQGYFRAGQGHC 2648
            Q+VDEC      C     C NTP  + C C  GY   G+ HC
Sbjct: 28   QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK-HC 68



 Score = 32.3 bits (72), Expect = 6.8
 Identities = 22/57 (38%), Positives = 26/57 (45%), Gaps = 8/57 (14%)

Query: 1854 QPCGNGTCKNIIGSYNCLCFP---GFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTA 1907
            QPC  GT +   G    LCFP   G    H G  + F +C T V   C  GH  NT+
Sbjct: 707  QPCPRGTYQPEAG--RTLCFPCGGGLTTKHEG-AISFQDCDTKV--QCSPGHYYNTS 758


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  234 bits (596), Expect = 1e-60
 Identities = 162/541 (29%), Positives = 228/541 (42%), Gaps = 122/541 (22%)

Query: 966  CPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERN 1025
            C  G   A+       P+  +  EC++    C    C + +   HCA   G +L  ++  
Sbjct: 37   CADGHRMATHQKDCSLPYATESKECRMVQEQC----CHSQLEELHCAT--GISLANEQDR 90

Query: 1026 CTDIDECRISPDL---------CGQGTCVNTPG-SFECECFPGYESGFMLMKNCM----- 1070
            C        S +          C  G      G S E     GY+ G +    C+     
Sbjct: 91   CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150

Query: 1071 ---------------DVDECARDPLL---CRGG-----TCTNTDGSYKCQCPPGHELTAK 1107
                           +V+E   DP L   CRGG      C +T     C C  G++L + 
Sbjct: 151  GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 1108 GTACEDIDECSLSDGLCPHGQ-CVNVIGAFQC----SCHAGFQSTPDRQ----------- 1151
            G +CED++EC      C  G+ C+N +G+F+C    SC  G++ T D             
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270

Query: 1152 ----------------------------------GCVDINECRVQNGGCDV--HCINTEG 1175
                                               C+DINEC   +  C +   CINTEG
Sbjct: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEG 330

Query: 1176 SYRC-----SCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMA 1229
            SY C     +CG+GY L  +G  C DVDEC      C +GH C N PG  RC C  G+  
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1230 TPDMRTCVDVDECDLNP-HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGG 1288
                R CVDV+EC   P  +C H  CENT GS++C C +G+ +      C D++EC    
Sbjct: 391  DGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--- 446

Query: 1289 HNCDSHASCLNIPGSFSCRCLPGWV---GDGFECHDLDECV--SQEHRCSPRGDCLNVPG 1343
             +      C N+ GS+ C C  G+     DG  C D+DEC   +  H CS R  C+N+PG
Sbjct: 447  -SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPG 503

Query: 1344 SYRCTCRQG---FAGDGFFCEDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDH 1399
            S++C+C       A +G  C+D DEC   +  C  N  C N  GG+RC   + F+  E++
Sbjct: 504  SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC---LAFECPENY 560

Query: 1400 R 1400
            R
Sbjct: 561  R 561



 Score =  219 bits (557), Expect = 4e-56
 Identities = 167/517 (32%), Positives = 225/517 (43%), Gaps = 97/517 (18%)

Query: 2111 CPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPG------LMMTC 2164
            C  G +    G +C  +    VG+ CGQ         F   C    E G      L  T 
Sbjct: 113  CLLGRAAQAQGQSCEYS--LMVGYQCGQV--------FRACCVKSQETGDLDVGGLQETD 162

Query: 2165 E--DIDECSLNPLL---------CAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECAD 2213
            +  +++E   +P L         C  +C +T    +C+C  GY L  DG  C DV+EC  
Sbjct: 163  KIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT 222

Query: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG------- 2266
            G   C   G  C N +G+F C          G+G   T+DN C    D C +G       
Sbjct: 223  GSHSCRL-GESCINTVGSFRCQRDSSC----GTGYELTEDNSC-KDIDECESGIHNCLPD 276

Query: 2267 -RCVNTAGSFRC----DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
              C NT GSFRC     C  GF     L  C DI +           C S+S        
Sbjct: 277  FICQNTLGSFRCRPKLQCKSGF-IQDALGNCIDINE-----------CLSIS-------- 316

Query: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPH-GSGY--TAEGR---DVDECRMLAHLCA 2375
            A C  G               G+   +K  P+ G GY    EG    DVDEC   A  C 
Sbjct: 317  APCPIGH--------TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368

Query: 2376 HG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP-KPCTFLCKNTKGSFLCSCPR 2433
             G  C+NS GSFRC C+ GY  D  +  C+D++EC + P + C   C+NT GS+LCSC  
Sbjct: 369  KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSV 428

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH---QACFDNDECS 2490
            G+ L  DGR+C+D++EC+S    C   C N  G++ C C  G+         C D DEC+
Sbjct: 429  GFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 486

Query: 2491 AQPGPCGAHGHCHNTPGSFRCEC-HQGFTLVSSGHGCEDVNEC-DGPHRC--QHGCQNQL 2546
               G       C N PGSF+C C   G+ L  +G  C+D++EC  G H C     C N  
Sbjct: 487  LPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQ 546

Query: 2547 GGYRC---SCPQGFTQHS----QWAQCVDENECALSP 2576
            GG+RC    CP+ + + +    +   C +  EC+  P
Sbjct: 547  GGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583



 Score =  215 bits (547), Expect = 6e-55
 Identities = 159/465 (34%), Positives = 211/465 (45%), Gaps = 59/465 (12%)

Query: 2330 RGWGPRCELCPLPGTSAYRKLCPHGSGYTAEG---RDVDECRMLAHLCAHGE-CINSLGS 2385
            RG GP  + C   G       C  G    ++G    DV+EC   +H C  GE CIN++GS
Sbjct: 181  RGGGPCKQQCRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239

Query: 2386 FRCH----CQAGY--TPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLC----SCPR 2433
            FRC     C  GY  T D    +C D+DEC      C   F+C+NT GSF C     C  
Sbjct: 240  FRCQRDSSCGTGYELTED---NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 2434 GYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR-----CPPGFTQHHQA--CF 2484
            G++ +  G  C D++EC S    C     C+NT G++TC+     C  G+  + +   C 
Sbjct: 297  GFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355

Query: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDG-PHR-CQHGC 2542
            D DEC+    PCG    C N+PGSFRCEC  G+        C DVNEC   P R C H C
Sbjct: 356  DVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKC 415

Query: 2543 QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFD 2602
            +N LG Y CSC  GF        C D NEC+ SP  C S  C N  G ++C C  G+   
Sbjct: 416  ENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--C-SQECANVYGSYQCYCRRGYQLS 472

Query: 2603 QALG-GCQEVDECAGRRGP--CSYSCANTPGGFLCGCP-QGYFRAGQG-------HCVSG 2651
               G  C+++DECA   G   CSY C N PG F C CP  GY  A  G        CV+G
Sbjct: 473  DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG 532

Query: 2652 LGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLG 2711
            +       +    E   + +  + C +    P +  R +A R  ++        + L L 
Sbjct: 533  I------HNCSINETCFNIQGGFRC-LAFECPENYRRSAATRCERLPCHENRECSKLPLR 585

Query: 2712 LNLSHLGRAERI------LELRPALEGLEGRIRYVIVRGNEQGFF 2750
            +   HL     I        + P+       ++  I  GNE+GFF
Sbjct: 586  ITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFF 630



 Score =  214 bits (546), Expect = 7e-55
 Identities = 136/379 (35%), Positives = 186/379 (49%), Gaps = 34/379 (8%)

Query: 1160 RVQNGG-CDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPG 1217
            R + GG C   C +T     CSC  GY L+ DG +C DV+EC      C  G  C N  G
Sbjct: 179  RCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVG 238

Query: 1218 GHRC----LCYDGFMATPDMRTCVDVDECDLNPHICLHG-DCENTKGSFVC----HCQLG 1268
              RC     C  G+  T D  +C D+DEC+   H CL    C+NT GSF C     C+ G
Sbjct: 239  SFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSG 297

Query: 1269 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCR-----CLPGW--VGDGFECHD 1321
            + ++     C D++EC      C    +C+N  GS++C+     C  G+    +G  C D
Sbjct: 298  F-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD 356

Query: 1322 LDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGF--FCEDRDECAENVDLCDNGQCL 1379
            +DEC      C     C+N PGS+RC C+ G+  DG    C D +EC          +C 
Sbjct: 357  VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE 416

Query: 1380 NAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYEL-DR 1438
            N  G Y C C +GF  + D R+C+D++EC+  + C+   C N+ G ++C C  GY+L D 
Sbjct: 417  NTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCS-QECANVYGSYQCYCRRGYQLSDV 474

Query: 1439 GGGNCTDINECADPV--NCINGVCINTPGSYLCSCPQD-FELNPSGVGCVD-----TRAG 1490
             G  C DI+ECA P   +  +  CIN PGS+ CSCP   + L P+G  C D     T   
Sbjct: 475  DGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 1491 NCFL-ETHDRGDSGISCSA 1508
            NC + ET      G  C A
Sbjct: 535  NCSINETCFNIQGGFRCLA 553



 Score =  211 bits (536), Expect = 1e-53
 Identities = 185/613 (30%), Positives = 240/613 (39%), Gaps = 120/613 (19%)

Query: 1079 PLLCRGGTC-----TNTDGSYKCQCPPGHELTAKGTACE-----DIDECSLSDGLCPHGQ 1128
            PLL  GG        + D   +  C  GH +      C      +  EC +    C H Q
Sbjct: 13   PLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQ 72

Query: 1129 CVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCS--CGQGYS 1186
                +    C+      +  DR        C   +G  D   +      RC   C  G +
Sbjct: 73   ----LEELHCATGISLANEQDR--------CATPHG--DNASLEATFVKRCCHCCLLGRA 118

Query: 1187 LMPDGRACADV----DECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC 1242
                G++C        +C +  R C    C         L   G   T  +   ++V+E 
Sbjct: 119  AQAQGQSCEYSLMVGYQCGQVFRAC----CVKSQETGD-LDVGGLQETDKI---IEVEEE 170

Query: 1243 DLNPHI---CLHG-----DCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSH 1294
              +P++   C  G      C +T    VC C +GY +      C DV+EC  G H+C   
Sbjct: 171  QEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLG 230

Query: 1295 ASCLNIPGSFSCRCLPGWVGDGFE------CHDLDECVSQEHRCSPRGDCLNVPGSYRC- 1347
             SC+N  GSF C+      G G+E      C D+DEC S  H C P   C N  GS+RC 
Sbjct: 231  ESCINTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCR 289

Query: 1348 ---TCRQGFAGDGF-FCEDRDECAENVDLCDNGQ-CLNAPGGYRCE-----CEMGFDPTE 1397
                C+ GF  D    C D +EC      C  G  C+N  G Y C+     C  G+   E
Sbjct: 290  PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 1398 DHRACQDVDECA-QGNLCAFG-SCENLPGMFRCICNGGYELDRGGGNCTDINECAD-PVN 1454
            +   C DVDECA     C  G  C N PG FRC C  GY  D     C D+NEC   P  
Sbjct: 350  EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409

Query: 1455 CINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGV 1514
                 C NT GSYLCSC   F L+  G  C D                   CS+      
Sbjct: 410  LCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDIN----------------ECSS------ 447

Query: 1515 TRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRIT-VILEDIDECQELPGL 1573
              + C       +G+            Y+  C    G+Q + +  V  EDIDEC     L
Sbjct: 448  --SPCSQECANVYGS------------YQCYC--RRGYQLSDVDGVTCEDIDEC----AL 487

Query: 1574 CQGGD-----CVNTFGSFQCECP-PGYHLSEHTRICEDIDECSTHSGICGPG-TCYNTLG 1626
              GG      C+N  GSFQC CP  GY L+ + R C+DIDEC T    C    TC+N  G
Sbjct: 488  PTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQG 547

Query: 1627 NYTCV---CPAEY 1636
             + C+   CP  Y
Sbjct: 548  GFRCLAFECPENY 560



 Score =  200 bits (509), Expect = 1e-50
 Identities = 146/438 (33%), Positives = 198/438 (45%), Gaps = 63/438 (14%)

Query: 884  RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSI 943
            +C +T     C C  G  L + G  C DV           +EC +T     R+   C  I
Sbjct: 189  QCRDTGDEVVCSCFVGYQLLSDGVSCEDV-----------NEC-ITGSHSCRLGESC--I 234

Query: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHG-TC 1002
              V    C+           S C  G G+   +  S     KD++EC+     C     C
Sbjct: 235  NTVGSFRCQR---------DSSC--GTGYELTEDNS----CKDIDECESGIHNCLPDFIC 279

Query: 1003 RNTVGSFHCA----CAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSFECEC-F 1056
            +NT+GSF C     C  GF  DA   NC DI+EC      C  G TC+NT GS+ C+   
Sbjct: 280  QNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNV 338

Query: 1057 PGYESGFMLMKN---CMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE 1112
            P    G+ L +    C+DVDECA     C +G  C N+ GS++C+C  G+        C 
Sbjct: 339  PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV 398

Query: 1113 DIDECSLSDG-LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCI 1171
            D++EC    G LC H +C N +G++ CSC  GF+ + D + C DINEC   +  C   C 
Sbjct: 399  DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQECA 455

Query: 1172 NTEGSYRCSCGQGYSLMP-DGRACADVDEC--EENPRVCDQGHCTNMPGGHRCLC-YDGF 1227
            N  GSY+C C +GY L   DG  C D+DEC       +C    C N+PG  +C C   G+
Sbjct: 456  NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGY 514

Query: 1228 MATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVC---HCQLGYMVRKGATGCSDVDE 1283
               P+ R C D+DEC    H C ++  C N +G F C    C   Y  R  AT C  +  
Sbjct: 515  RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR-RSAATRCERLP- 572

Query: 1284 CEVGGHNCDSHASCLNIP 1301
                   C  +  C  +P
Sbjct: 573  -------CHENRECSKLP 583



 Score =  188 bits (478), Expect = 6e-47
 Identities = 162/511 (31%), Positives = 218/511 (42%), Gaps = 88/511 (17%)

Query: 1672 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCG---------NQAPGFLTDI----HTGK 1718
            K CC    +G+A     ++C   +   YQ  CG         +Q  G L D+     T K
Sbjct: 107  KRCCHCCLLGRAAQAQGQSCEYSLMVGYQ--CGQVFRACCVKSQETGDL-DVGGLQETDK 163

Query: 1719 PLDIDECGEIPAI---CANG-----ICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
             ++++E  E P +   C  G      C +      C C  G+   S  ++CEDV+EC + 
Sbjct: 164  IIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITG 223

Query: 1771 ESPCQQNADCINIPGSYRCK----CTRGYKLSPGGACVGRNECRE-IPNVCSHGDCMDTE 1825
               C+    CIN  GS+RC+    C  GY+L+   +C   +EC   I N      C +T 
Sbjct: 224  SHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 1826 GSYMCL----CHRGFQASADQTLCMDIDEC--DRQPCGNG-TCKNIIGSYNCL-----CF 1873
            GS+ C     C  GF   A    C+DI+EC     PC  G TC N  GSY C      C 
Sbjct: 284  GSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCG 342

Query: 1874 PGFVVTHNGD-CVDFDECTTLVGQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNCVDTN 1931
             G+ +   G  CVD DEC     + C  GH C+N+ GSF C C+ G+      + CVD N
Sbjct: 343  RGYHLNEEGTRCVDVDECAP-PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401

Query: 1932 ECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSP 1989
            EC    G      C+N  GS+ C C  GF++  D   C DI+ECS  P       C N  
Sbjct: 402  ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP---CSQECANVY 458

Query: 1990 GSFQCLCPPGFVLSD-NGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEG 2048
            GS+QC C  G+ LSD +G  C D             +C++P   +    RC     PG  
Sbjct: 459  GSYQCYCRRGYQLSDVDGVTCED-----------IDECALPTGGHICSYRCI--NIPG-- 503

Query: 2049 WGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCT-NGVCVNTDGSF 2107
                C  CP  G      L P G           +D++EC      C+ N  C N  G F
Sbjct: 504  -SFQCS-CPSSG----YRLAPNGRNC--------QDIDECVTGIHNCSINETCFNIQGGF 549

Query: 2108 RC---ECPFGY----SLDFTGINCVDTDECS 2131
            RC   ECP  Y    +     + C +  ECS
Sbjct: 550  RCLAFECPENYRRSAATRCERLPCHENRECS 580



 Score =  176 bits (447), Expect = 2e-43
 Identities = 144/455 (31%), Positives = 187/455 (41%), Gaps = 77/455 (16%)

Query: 451 DECTSS-PCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNT 508
           D C    PC    C +      C C+ G+Q      +C DV+ECI     C LG  C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 509 EGSFQC----VCNAGFELSPDGKNCVDHNECATS--TMCVNGVCLNEDGSFSC----LCK 558
            GSF+C     C  G+EL+ D  +C D +EC +       + +C N  GSF C     CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 559 PGFLLAPGGHYCMDIDEC-QTPGICVNGH-CTNTEGSFRCQ-----CLGGLAVGTDGRVC 611
            GF+    G+ C+DI+EC      C  GH C NTEGS+ CQ     C  G  +  +G  C
Sbjct: 296 SGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354

Query: 612 VDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCS 671
           VD               CA P       +E C      G G  C   P      F+  C 
Sbjct: 355 VDV------------DECAPP-------AEPC------GKGHRCVNSP----GSFRCECK 385

Query: 672 SGL---GITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDEC 728
           +G    GI+    D+NEC   P       CEN  GSY C C++G+     G+ C D++EC
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445

Query: 729 ALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQ-DTEICKDVDEC---LSSPCVSGVCRNLA 784
             +S  C    C N  GSY C C  G+     D   C+D+DEC         S  C N+ 
Sbjct: 446 --SSSPCSQE-CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP 502

Query: 785 GSYTCKC-GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWG 843
           GS+ C C   G RL P+G  C D              C   +   S+   C    G   G
Sbjct: 503 GSFQCSCPSSGYRLAPNGRNCQDI-----------DECVTGIHNCSINETCFNIQG---G 548

Query: 844 SPCERCEIDPACARGFA-RMTGVTCDDVNECESFP 877
             C   E      R  A R   + C +  EC   P
Sbjct: 549 FRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583



 Score =  171 bits (432), Expect = 1e-41
 Identities = 128/421 (30%), Positives = 184/421 (43%), Gaps = 63/421 (14%)

Query: 1945 CQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFG-TCTNSPGSFQCLCPPGFV 2001
            C++      C C  G+Q+ SD   C D++EC    + C  G +C N+ GSF+C       
Sbjct: 190  CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC------- 242

Query: 2002 LSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKT---RCCCSKRPGEGWGDPCELCPQ 2058
                       R S C T +E  + +  K  +  ++    C            P  +C  
Sbjct: 243  ----------QRDSSCGTGYELTEDNSCKDIDECESGIHNCL-----------PDFICQN 281

Query: 2059 E-GSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNG-VCVNTDGSFRCE-----C 2111
              GS   +       G +     +  D+NEC      C  G  C+NT+GS+ C+     C
Sbjct: 282  TLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341

Query: 2112 PFGYSLDFTGINCVDTDECSV-GHPCGQG-TCTNVIGGFECACADGFE-PGLMMTCEDID 2168
              GY L+  G  CVD DEC+    PCG+G  C N  G F C C  G+   G+   C D++
Sbjct: 342  GRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401

Query: 2169 ECSLNP-LLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKN 2227
            EC   P  LC  +C NT GSYLC+C  G+ L  DG  C D++EC+     C     EC N
Sbjct: 402  ECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC---SQECAN 456

Query: 2228 LIGTFACVCPPGMRPLPGSGEGCTDDNECHAQP---DLCVNGRCVNTAGSFRCDC-DEGF 2283
            + G++ C C  G +     G  C D +EC A P    +C + RC+N  GSF+C C   G+
Sbjct: 457  VYGSYQCYCRRGYQLSDVDGVTCEDIDEC-ALPTGGHIC-SYRCINIPGSFQCSCPSSGY 514

Query: 2284 QPSPTLTECHDIRQGPCFAEV----LQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELC 2339
            + +P    C DI +  C   +    +   C ++      +   EC     R    RCE  
Sbjct: 515  RLAPNGRNCQDIDE--CVTGIHNCSINETCFNIQGGFRCLA-FECPENYRRSAATRCERL 571

Query: 2340 P 2340
            P
Sbjct: 572  P 572



 Score =  166 bits (421), Expect = 2e-40
 Identities = 144/506 (28%), Positives = 192/506 (37%), Gaps = 124/506 (24%)

Query: 2022 EAGKCSVPKAFNTTKT--------RCCCSKRPGEGWGDPCELCPQEG---SAAFQELC-- 2068
            E  +C+ P   N +           CC   R  +  G  CE     G      F+  C  
Sbjct: 87   EQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVK 146

Query: 2069 --PFGHGAVPGPDDSRE--DVNECAENPGV---CTNG-----VCVNTDGSFRCECPFGYS 2116
                G   V G  ++ +  +V E  E+P +   C  G      C +T     C C  GY 
Sbjct: 147  SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQ 206

Query: 2117 LDFTGINCVDTDECSVG-HPCGQG-TCTNVIGGFEC----ACADGFEPGLMMTCEDIDEC 2170
            L   G++C D +EC  G H C  G +C N +G F C    +C  G+E     +C+DIDEC
Sbjct: 207  LLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDEC 266

Query: 2171 S------LNPLLC-----AFRCH------------------------------------- 2182
                   L   +C     +FRC                                      
Sbjct: 267  ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI 326

Query: 2183 NTEGSYLC-----TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCP 2237
            NTEGSY C      C  GY L E+G  C DVDECA   + C  +G  C N  G+F C C 
Sbjct: 327  NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECK 385

Query: 2238 PGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
             G     G    C D NEC   P      +C NT GS+ C C  GF+ S     C DI +
Sbjct: 386  TGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINE 444

Query: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGY 2357
              C +      C ++  S       +C C  G       +L  + G +            
Sbjct: 445  --CSSSPCSQECANVYGS------YQCYCRRG------YQLSDVDGVTC----------- 479

Query: 2358 TAEGRDVDECRML--AHLCAHGECINSLGSFRCHC-QAGYTPDATATTCLDMDECSQVPK 2414
                 D+DEC +    H+C++  CIN  GSF+C C  +GY        C D+DEC     
Sbjct: 480  ----EDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIH 534

Query: 2415 PCTF--LCKNTKGSFLC---SCPRGY 2435
             C+    C N +G F C    CP  Y
Sbjct: 535  NCSINETCFNIQGGFRCLAFECPENY 560



 Score =  162 bits (411), Expect = 3e-39
 Identities = 143/472 (30%), Positives = 200/472 (42%), Gaps = 95/472 (20%)

Query: 1371 DLCDNG-----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN-LCAFG-SCENLP 1423
            D C  G     QC +      C C +G+    D  +C+DV+EC  G+  C  G SC N  
Sbjct: 178  DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 1424 GMFRC----ICNGGYELDRGGGNCTDINECADPV-NCI-NGVCINTPGSYLCSCPQDFEL 1477
            G FRC     C  GYEL     +C DI+EC   + NC+ + +C NT GS+ C      + 
Sbjct: 238  GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 1478 NPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMA 1537
                 G +    GNC     D  +  +S SA   +G T   C  + G             
Sbjct: 297  -----GFIQDALGNCI----DINEC-LSISAPCPIGHT---CINTEG------------- 330

Query: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCECPPGYHL 1596
            + T  + +   G G+  N       D+DEC      C +G  CVN+ GSF+CEC  GY+ 
Sbjct: 331  SYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYF 390

Query: 1597 SEHTRICEDIDECSTHSG-ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR 1655
               +R+C D++EC  + G +CG   C NTLG+Y C C   +     G +C D+ +     
Sbjct: 391  DGISRMCVDVNECQRYPGRLCG-HKCENTLGSYLCSCSVGFRLSVDGRSCEDINE----- 444

Query: 1656 HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILC--GNQAPGFLTD 1713
                                CS       + PC      +   YQ  C  G Q    L+D
Sbjct: 445  --------------------CS-------SSPCSQECANVYGSYQCYCRRGYQ----LSD 473

Query: 1714 IHTGKPLDIDECGEIPA---ICANGICINQIGSFRCECP-AGFNYNSILLACEDVDECGS 1769
            +      DIDEC  +P    IC+   CIN  GSF+C CP +G+        C+D+DEC +
Sbjct: 474  VDGVTCEDIDECA-LPTGGHICSYR-CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVT 531

Query: 1770 RESPCQQNADCINIPGSYRC---KCTRGYKLSPGGACV-----GRNECREIP 1813
                C  N  C NI G +RC   +C   Y+ S    C         EC ++P
Sbjct: 532  GIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583



 Score =  162 bits (410), Expect = 4e-39
 Identities = 113/377 (29%), Positives = 162/377 (42%), Gaps = 59/377 (15%)

Query: 2352 PHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS---------------FRCHC-QAGYT 2395
            PHG   + E   V  C    H C  G    + G                FR  C ++  T
Sbjct: 94   PHGDNASLEATFVKRC---CHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQET 150

Query: 2396 PDATATTCLDMDECSQVPK---------------PCTFLCKNTKGSFLCSCPRGYLLEED 2440
             D       + D+  +V +               PC   C++T    +CSC  GY L  D
Sbjct: 151  GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSD 210

Query: 2441 GRTCKDLDECTSRQHNCQF--LCVNTVGAFTCR----CPPGF-TQHHQACFDNDECSAQP 2493
            G +C+D++EC +  H+C+    C+NTVG+F C+    C  G+      +C D DEC +  
Sbjct: 211  GVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI 270

Query: 2494 GPCGAHGHCHNTPGSFRC----ECHQGFTLVSSGHGCEDVNEC---DGPHRCQHGCQNQL 2546
              C     C NT GSFRC    +C  GF   + G+ C D+NEC     P    H C N  
Sbjct: 271  HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTE 329

Query: 2547 GGYRC-----SCPQGFTQHSQWAQCVDENECALSPPTCGSA-SCRNTLGGFRCVCPSGFD 2600
            G Y C     +C +G+  + +  +CVD +ECA     CG    C N+ G FRC C +G+ 
Sbjct: 330  GSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY 389

Query: 2601 FDQALGGCQEVDECAGRRGP-CSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
            FD     C +V+EC    G  C + C NT G +LC C  G+  +  G     +       
Sbjct: 390  FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC---S 446

Query: 2660 DTPDKEELLSSEACYEC 2676
             +P  +E  +    Y+C
Sbjct: 447  SSPCSQECANVYGSYQC 463



 Score =  162 bits (409), Expect = 6e-39
 Identities = 179/661 (27%), Positives = 252/661 (38%), Gaps = 138/661 (20%)

Query: 479  QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-----VDHN 533
            +A P+R+  + +   ++ GGL  L   V+ +   +  C  G  ++   K+C      +  
Sbjct: 3    RAAPSRRVPLPL---LLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESK 59

Query: 534  ECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGS 593
            EC    M     C ++     C        A G     + D C TP    +G   + E +
Sbjct: 60   ECR---MVQEQCCHSQLEELHC--------ATGISLANEQDRCATP----HGDNASLEAT 104

Query: 594  F--RCQ--CLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARP----------------F 633
            F  RC   CL G A    G+ C  + +     G + +  C +                  
Sbjct: 105  FVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKI 164

Query: 634  PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDP 690
                 + E    N     G PC+        E    C  G  + +DG    D+NEC    
Sbjct: 165  IEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGS 224

Query: 691  EVCANGV-CENLRGSYRCV----CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSP 744
              C  G  C N  GS+RC     C  GYE       C D+DEC      C   + CQN+ 
Sbjct: 225  HSCRLGESCINTVGSFRCQRDSSCGTGYEL-TEDNSCKDIDECESGIHNCLPDFICQNTL 283

Query: 745  GSYSC----SCPPGFHFWQDT-EICKDVDECLS--SPCVSG-VCRNLAGSYTCK-----C 791
            GS+ C     C  GF   QD    C D++ECLS  +PC  G  C N  GSYTC+     C
Sbjct: 284  GSFRCRPKLQCKSGFI--QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341

Query: 792  GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEI 851
            G G  L+  GT C+D  +           C    +       C  + G+       RCE 
Sbjct: 342  GRGYHLNEEGTRCVDVDE-----------CAPPAEPCGKGHRCVNSPGSF------RCE- 383

Query: 852  DPACARGFARMTGVT--CDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC 909
               C  G+    G++  C DVNEC+ +PG     +C NT GS+ C C  G  L   GR C
Sbjct: 384  ---CKTGYY-FDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSC 439

Query: 910  VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG 969
             D+           +EC            C      V+G             +   C RG
Sbjct: 440  EDI-----------NECS--------SSPCSQECANVYG------------SYQCYCRRG 468

Query: 970  LGFASRDFLSGRPFYKDVNECKVFPG--LCTHGTCRNTVGSFHCAC-AGGFALDAQERNC 1026
               +  D ++     +D++EC +  G  +C++  C N  GSF C+C + G+ L    RNC
Sbjct: 469  YQLSDVDGVT----CEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNC 523

Query: 1027 TDIDECRISPDLCG-QGTCVNTPGSFEC---ECFPGYESGFMLMKN---CMDVDECARDP 1079
             DIDEC      C    TC N  G F C   EC   Y            C +  EC++ P
Sbjct: 524  QDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLP 583

Query: 1080 L 1080
            L
Sbjct: 584  L 584



 Score =  151 bits (382), Expect = 8e-36
 Identities = 113/350 (32%), Positives = 151/350 (43%), Gaps = 61/350 (17%)

Query: 409 IDICRHFTNLCL-NGRCLPTPSSYRC----ECNVGYTQDVRGECIDVDEC--TSSPCHHG 461
           ID C    + CL +  C  T  S+RC    +C  G+ QD  G CID++EC   S+PC  G
Sbjct: 263 IDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIG 322

Query: 462 -DCVNIPGTYHCR-----CYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQC 514
             C+N  G+Y C+     C  G+        CVDVDEC      C  G RCVN+ GSF+C
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC 382

Query: 515 VCNAGFELSPDGKNCVDHNECA--TSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMD 572
            C  G+      + CVD NEC      +C    C N  GS+ C C  GF L+  G  C D
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLC-GHKCENTLGSYLCSCSVGFRLSVDGRSCED 441

Query: 573 IDECQTPGICVNGHCTNTEGSFRCQCLGGLAVG-TDGRVCVDTHVRSTCYGAIEKGSCAR 631
           I+EC +     +  C N  GS++C C  G  +   DG  C D               CA 
Sbjct: 442 INECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDI------------DECAL 487

Query: 632 PFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC-SSGLGITTDGR---DINECA 687
           P  G +    C                       FQ  C SSG  +  +GR   DI+EC 
Sbjct: 488 PTGGHICSYRC-----------------INIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530

Query: 688 LDPEVCA-NGVCENLRGSYRCV---CNLGYEAGASGK----DCTDVDECA 729
                C+ N  C N++G +RC+   C   Y   A+ +     C +  EC+
Sbjct: 531 TGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580



 Score =  147 bits (370), Expect = 2e-34
 Identities = 137/465 (29%), Positives = 181/465 (38%), Gaps = 77/465 (16%)

Query: 193 PEGCQHQLTGLVCTKALCCATVGRA---WGLPCELCPAQPHPCRRGF---------IPNI 240
           P G    L      +   C  +GRA    G  CE      + C + F           ++
Sbjct: 94  PHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDL 153

Query: 241 HTGACQDVD------ECQAVPGL---CQGGS-----CVNMVGSFHCRCPVGHRLSDSSAA 286
             G  Q+ D      E Q  P L   C+GG      C +      C C VG++L     +
Sbjct: 154 DVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVS 213

Query: 287 CEDYRA--GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
           CED         S   G  C   +     +R   C  G         EL       +  +
Sbjct: 214 CEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGY--------ELTEDNSCKDIDE 265

Query: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
                        G+   L  F        LG  R  P      G      GN       
Sbjct: 266 C----------ESGIHNCLPDFICQNT---LGSFRCRPKLQCKSGFIQDALGNC------ 306

Query: 405 LNQTIDI--CRHFTNLCLNGR-CLPTPSSYRCECNV-----GYTQDVRG-ECIDVDECT- 454
               IDI  C   +  C  G  C+ T  SY C+ NV     GY  +  G  C+DVDEC  
Sbjct: 307 ----IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP 362

Query: 455 -SSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512
            + PC  G  CVN PG++ C C  G+      + CVDV+EC    G     +C NT GS+
Sbjct: 363 PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSY 422

Query: 513 QCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAP-GGHYCM 571
            C C+ GF LS DG++C D NEC++S    +  C N  GS+ C C+ G+ L+   G  C 
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCE 480

Query: 572 DIDECQTP--GICVNGHCTNTEGSFRCQC-LGGLAVGTDGRVCVD 613
           DIDEC  P  G   +  C N  GSF+C C   G  +  +GR C D
Sbjct: 481 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 111/458 (24%), Positives = 151/458 (32%), Gaps = 135/458 (29%)

Query: 85  ICRRACGEGFCSQPNLCTCADGTLAPSCG----VSRGSGCSVSCMNGGTCRGA--SCLCQ 138
           IC+   G   C +P L  C  G +  + G    ++     S  C  G TC     S  CQ
Sbjct: 278 ICQNTLGSFRC-RPKL-QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQ 335

Query: 139 KGYTGTVCGQPICDRGCH---NGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG 195
           K         P C RG H    G RC+  + CA       P  E   +   C    G   
Sbjct: 336 KNV-------PNCGRGYHLNEEGTRCVDVDECA-------PPAEPCGKGHRCVNSPGSFR 381

Query: 196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVP 255
           C+                                  C+ G+  +  +  C DV+ECQ  P
Sbjct: 382 CE----------------------------------CKTGYYFDGISRMCVDVNECQRYP 407

Query: 256 GLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR 315
           G   G  C N +GS+ C C VG RLS    +CED     C S      C+ + A  Y   
Sbjct: 408 GRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED--INECSS----SPCSQECANVYGSY 461

Query: 316 QCCCDRGRCWA------AGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSN 369
           QC C RG   +         + E   P G +    +C+ R   +P            GS 
Sbjct: 462 QCYCRRGYQLSDVDGVTCEDIDECALPTGGH----ICSYRCINIP------------GSF 505

Query: 370 GMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDIC-RHFTNLCLNGRCLPTP 428
               P    RL P+G +                    Q ID C     N  +N  C    
Sbjct: 506 QCSCPSSGYRLAPNGRNC-------------------QDIDECVTGIHNCSINETCFNIQ 546

Query: 429 SSYRC---ECNVGYTQDVRGECIDVDECTSSPCHHG-DCVNIP--GTYHCRCYPG----- 477
             +RC   EC   Y +           C   PCH   +C  +P   TY+   +P      
Sbjct: 547 GGFRCLAFECPENYRRSA------ATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP 600

Query: 478 ---FQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512
              F+  P+     D  +  ++GG        N EG F
Sbjct: 601 AVVFRMGPSSAVPGDSMQLAITGG--------NEEGFF 630



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 105/423 (24%), Positives = 142/423 (33%), Gaps = 87/423 (20%)

Query: 86  CRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSV--SCMNGG-TCR-GASCLCQKGY 141
           C++ C +       +C+C  G    S GVS    C     C+ G  +CR G SC+   G 
Sbjct: 186 CKQQCRD--TGDEVVCSCFVGYQLLSDGVS----CEDVNECITGSHSCRLGESCINTVG- 238

Query: 142 TGTVCGQPICDRGCHNGGRCIGPNRCA----CVYGFMGPQCERDYRTGPCFGQVGPEGCQ 197
               C +   D  C  G      N C     C  G     C  D+    C   +G   C+
Sbjct: 239 -SFRCQR---DSSCGTGYELTEDNSCKDIDECESGIHN--CLPDFI---CQNTLGSFRCR 289

Query: 198 HQL---TGLVCTKALCCATVGRAWGL--PCEL------------CPAQPHPCRRGFIPNI 240
            +L   +G +      C  +     +  PC +            C      C RG+  N 
Sbjct: 290 PKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNE 349

Query: 241 HTGACQDVDECQAVPGLC-QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACF-SV 298
               C DVDEC      C +G  CVN  GSF C C  G+     S  C D      +   
Sbjct: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGR 409

Query: 299 LFGGRCAGDLAGHYTRRQCCCDRG-RCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHP 357
           L G +C   L  +     C C  G R    G   E      S+   Q CA          
Sbjct: 410 LCGHKCENTLGSYL----CSCSVGFRLSVDGRSCEDINECSSSPCSQECA---------- 455

Query: 358 GLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTN 417
                      N  G      R     SD  G+        +I    L     IC +   
Sbjct: 456 -----------NVYGSYQCYCRRGYQLSDVDGVTC-----EDIDECALPTGGHICSY--- 496

Query: 418 LCLNGRCLPTPSSYRCEC-NVGYTQDVRG-ECIDVDECTSS--PCHHGD-CVNIPGTYHC 472
                RC+  P S++C C + GY     G  C D+DEC +    C   + C NI G + C
Sbjct: 497 -----RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551

Query: 473 RCY 475
             +
Sbjct: 552 LAF 554


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  231 bits (588), Expect = 1e-59
 Identities = 307/1180 (26%), Positives = 446/1180 (37%), Gaps = 214/1180 (18%)

Query: 761  TEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESR 820
            +E C    +CLS           + +Y+C C P      SG +C +     C  K     
Sbjct: 180  SEFCSGHGKCLSEAW--------SKTYSCHCQPPF----SGKYCQELD--ACSFK----P 221

Query: 821  CEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDV-NECESFPGV 879
            C+ N          C      W      C   P         TG  C ++  +C+  P V
Sbjct: 222  CKNN--------GSCINKRENWDEQAYECVCHPP-------FTGKNCSEIIGQCQ--PHV 264

Query: 880  CPNGRCVN-TAGSFRCECPEGLMLDASGRLCVDVRLEPC--FLRWDEDECGVTLPGKYRM 936
            C +G C N T+ SF CEC E      SG  C +V  +PC   L W    C    P     
Sbjct: 265  CFHGNCSNITSNSFICECDEQF----SGPFC-EVSAKPCVSLLFWKRGIC----PNSSSA 315

Query: 937  DVCCCSIGAVWGVECEACPDPESLEFASL-CPRGLGFA--SRDFLS-GRPFYKDV----- 987
                C  G+          + +  EF+ + C  G      S D +    P + D+     
Sbjct: 316  YTYECPKGS-----SSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSI 370

Query: 988  -NECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTD-IDECRISPDLC-GQGTC 1044
               C+ FP L  + TC+     + C+C  GF     E+NC   ID C++    C  +  C
Sbjct: 371  QTSCESFP-LRNNATCKKCEKDYPCSCISGFT----EKNCEKAIDHCKLLSINCLNEEWC 425

Query: 1045 VNTPGSFECECFPGY-ESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSY--------- 1094
             N  G F+  C PG  ++    +KN   + +      +   G C +   +          
Sbjct: 426  FNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGF 485

Query: 1095 ------KCQCPPGHELTAKGTACED---IDECSLSDGLC--PHGQCVNVIGAFQCSCHAG 1143
                  KCQ              ED   +++   ++  C  PH +    I A  CSC + 
Sbjct: 486  AGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPH-EGTKEICANGCSCLSE 544

Query: 1144 FQSTPDRQGCV---------------DINECRVQNGGCDVHCINTEGSYRCSCGQGYSLM 1188
              S   R  C                  NEC+ +       C +     RCSC   Y   
Sbjct: 545  EDSQEYRYLCFLRWAGNMYLENTTDDQENECQHE-----AVCKDEINRPRCSCSLSYI-- 597

Query: 1189 PDGRACA-DVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPH 1247
              GR C  +VD C  N  +   G C  +   H C C  G       R   ++D  D    
Sbjct: 598  --GRLCVVNVDYCLGNHSISVHGLCLAL--SHNCNC-SGLQRYE--RNICEIDTEDCKSA 650

Query: 1248 ICLHGDCE-NTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC 1306
             C +G    + +G F   C  G+   KG     D+DEC    H C + A+C++ PG++ C
Sbjct: 651  SCKNGTTSTHLRGYFFRKCVPGF---KGTQCEIDIDEC--ASHPCKNGATCIDQPGNYFC 705

Query: 1307 RCLPGW-VGDGFEC------------HDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF 1353
            +C+P + V DGF C             D+D+C+   + C     C ++  SY+C C   +
Sbjct: 706  QCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCIL--NACEHNSTCKDLHLSYQCVCLSDW 763

Query: 1354 AGDGFFCE-DRDECAENVDLCDNGQCLNAPGGYRCECEMGF---DPTEDHRACQDVDECA 1409
             G+  FCE + +EC  N    +N  C +    YRCEC  G+   + +E+   C D D C 
Sbjct: 764  EGN--FCEQESNECKMN-PCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINEC-DSDPCM 819

Query: 1410 QGNLCAFGSCENLPGMFRCICNGGY--ELDRGGGNCTDI--NECADPVNCINGVCINTPG 1465
             G LC   +   +PG F C+C   Y  +      N  D+  N C +   C+  V  N   
Sbjct: 820  NGGLCHEST---IPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQH- 875

Query: 1466 SYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGD-----SGISCSAEIGVGVTRASCC 1520
               C C ++FE    G  C        FL   D GD     +   C      G + + C 
Sbjct: 876  ---CICREEFE----GKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICR--PGFSGSLCE 926

Query: 1521 CSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILE-DIDECQELPGLCQGGDC 1579
              +      PC+          R  C      +P       E D+++C+  P L +  +C
Sbjct: 927  IEINECSSEPCKNNGTCVDLTNRFFC----NCEPEYHGPFCELDVNKCKISPCLDEE-NC 981

Query: 1580 VNTFGSFQCECPPGYHLSEHTRI-CE-DIDECSTHSGICGPGTCYNTLGNYTCVCPAEYL 1637
            V     + C C PGY     T I CE ++DEC +   +   G C + + +YTC C + + 
Sbjct: 982  VYRTDGYNCLCAPGY-----TGINCEINLDECLSEPCL-HDGVCIDGINHYTCDCKSGFF 1035

Query: 1638 QVNGGNNCMDMRKSVCFRHYNGTCQNEL--AFNVTRKMCCCSYNIGQAWNRPC--EACPT 1693
              +   N  D   + C         NE   + +       C   I    + PC  E    
Sbjct: 1036 GTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQ 1095

Query: 1694 PISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIP---AICANG-ICINQIG-SFRCEC 1748
              +  +  +C    P   T  +  K   ID C E      IC NG IC++  G +F C C
Sbjct: 1096 KSAHGFTCIC----PRGYTGAYCEK--SIDNCAEPELNSVICLNGGICVDGPGHTFDCRC 1149

Query: 1749 PAGFNYNSILLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRN 1807
              GF+       CE +++EC S  SPC   ADC +    Y CKC  G+    G  C    
Sbjct: 1150 LPGFSGQF----CEININECSS--SPCLHGADCEDHINGYVCKCQPGWS---GHHCENEL 1200

Query: 1808 ECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
            EC  IPN C H  CM+ E    CLC  GF   +   LC D
Sbjct: 1201 EC--IPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGD 1238



 Score =  228 bits (581), Expect = 6e-59
 Identities = 288/1181 (24%), Positives = 428/1181 (36%), Gaps = 303/1181 (25%)

Query: 1324 ECVSQEHRCSPRGDCLNVPGS--YRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNA 1381
            E +S E  CS  G CL+   S  Y C C+  F+G   +C++ D C+      +NG C+N 
Sbjct: 176  ESLSSEF-CSGHGKCLSEAWSKTYSCHCQPPFSGK--YCQELDACSFK-PCKNNGSCINK 231

Query: 1382 -----PGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPG-MFRCICNGGYE 1435
                    Y C C     P    + C ++    Q ++C  G+C N+    F C C+  + 
Sbjct: 232  RENWDEQAYECVCH----PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFS 287

Query: 1436 LDRGGGNC-TDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFL 1494
                G  C      C   +    G+C N+  +Y   CP+            +T      L
Sbjct: 288  ----GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNG-----ETDVSEFSL 338

Query: 1495 ETHDRGDSGISCSAEIGVGVTRASCCCS------LGRAWGNPCELCPMANTTEYRTL--- 1545
                 G   I  S ++        C CS      L ++    CE  P+ N    +     
Sbjct: 339  VPCQNGTDCIKISNDV-------MCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKD 391

Query: 1546 --CPGGEGFQPNRITVILEDIDECQELPGLCQGGD-CVNTFGSFQCECPPG------YHL 1596
              C    GF         + ID C+ L   C   + C N  G F+  C PG      + L
Sbjct: 392  YPCSCISGFTEKNCE---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFL 448

Query: 1597 SEHTRICEDIDECS-THSGIC---GPGT----------------CYNTLGNY-----TCV 1631
                 I + +  C  T  GIC   GP                  C   +  Y      C 
Sbjct: 449  KNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCT 508

Query: 1632 CPAEYLQVNGGNN-------------------CMDMRKS-----VCFRHYNGT------- 1660
              A Y+     NN                   C+    S     +CF  + G        
Sbjct: 509  EDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTT 568

Query: 1661 ------CQNELAFN--VTRKMCCCSYN-IGQAWNRPCEACPTPISPDYQILC-----GNQ 1706
                  CQ+E      + R  C CS + IG+      + C    S     LC        
Sbjct: 569  DDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCN 628

Query: 1707 APGFLTDIHTGKPLDIDECGEIPAICANGICINQI-GSFRCECPAGFNYNSILLACE-DV 1764
              G          +D ++C    A C NG     + G F  +C  GF        CE D+
Sbjct: 629  CSGLQRYERNICEIDTEDCKS--ASCKNGTTSTHLRGYFFRKCVPGFKGTQ----CEIDI 682

Query: 1765 DECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRN-----ECRE-----IPN 1814
            DEC S   PC+  A CI+ PG+Y C+C   +K+  G +C+         C +     I N
Sbjct: 683  DECASH--PCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILN 740

Query: 1815 VCSHGD-CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPC-GNGTCKNIIGSYNCLC 1872
             C H   C D   SY C+C   ++ +  +    + +EC   PC  N TC ++  SY C C
Sbjct: 741  ACEHNSTCKDLHLSYQCVCLSDWEGNFCE---QESNECKMNPCKNNSTCTDLYKSYRCEC 797

Query: 1873 FPGFVVTHNGDCV---DFDEC--------TTLVGQ-VC--------RFGH---------- 1902
              G+   +  + +   D D C        +T+ GQ VC        +F H          
Sbjct: 798  TSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLH 857

Query: 1903 --CLNTA-------GSFHCLCQDGFELTADGKNC-VDTNECLSLAGTCLP-GTCQNLEGS 1951
              C N +        + HC+C++ FE    GKNC +D  +CL L+  C   G C+++  +
Sbjct: 858  NPCRNNSTCLALVDANQHCICREEFE----GKNCEIDVKDCLFLS--CQDYGDCEDMVNN 911

Query: 1952 FRCICPPGFQVQSDHC-IDIDECSEEPNLCLF-GTCTNSPGSFQCLCPPGFVLSDNGHRC 2009
            FRCIC PGF      C I+I+ECS EP  C   GTC +    F C C P +         
Sbjct: 912  FRCICRPGFS--GSLCEIEINECSSEP--CKNNGTCVDLTNRFFCNCEPEY--------- 958

Query: 2010 FDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCP 2069
                  FC    +  KC +    +      C  +  G                 +  LC 
Sbjct: 959  ---HGPFC--ELDVNKCKISPCLDEEN---CVYRTDG-----------------YNCLCA 993

Query: 2070 FGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDE 2129
             G+  +    +   +++EC   P +  +GVC++    + C+C  G    F G +C     
Sbjct: 994  PGYTGI----NCEINLDECLSEPCL-HDGVCIDGINHYTCDCKSG----FFGTHCETNAN 1044

Query: 2130 CSVGHPCGQGTCTNVIGGFECAC-ADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSY 2188
              + +PC  G CT +I  + C+C ADG      +    I++C+  P +    C  +   +
Sbjct: 1045 DCLSNPCLHGRCTELINEYPCSCDADGTSTQCKI---KINDCTSIPCMNEGFCQKSAHGF 1101

Query: 2189 LCTCPAGYTLREDGAMC-RDVDECADGQQ-------------------DCHA-------- 2220
             C CP GYT    GA C + +D CA+ +                    DC          
Sbjct: 1102 TCICPRGYT----GAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQF 1157

Query: 2221 --------------RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG 2266
                           G +C++ I  + C C PG      SG  C ++ EC   P+ CV+ 
Sbjct: 1158 CEININECSSSPCLHGADCEDHINGYVCKCQPGW-----SGHHCENELEC--IPNSCVHE 1210

Query: 2267 RCVNTAGSFRCDCDEGFQPSPTLTECHD-IRQGPCFAEVLQ 2306
             C+       C C  GF        C D IR+  C   + Q
Sbjct: 1211 LCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQ 1251



 Score =  228 bits (580), Expect = 8e-59
 Identities = 297/1249 (23%), Positives = 452/1249 (36%), Gaps = 273/1249 (21%)

Query: 516  CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGS--FSCLCKPGFLLAPGGHYCMDI 573
            C  G  L+   K        ++     +G CL+E  S  +SC C+P F     G YC ++
Sbjct: 159  CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQEL 214

Query: 574  DECQTPGICVNGHCTN-----TEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGS 628
            D C       NG C N      E ++ C C         G+ C      S   G  +   
Sbjct: 215  DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFT----GKNC------SEIIGQCQPHV 264

Query: 629  CARPFPGTVTKSECCCANPDHGFGEPCQ---------------LCPAKDSAEFQALCSSG 673
            C       +T +   C   +   G  C+               +CP   SA +   C  G
Sbjct: 265  CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSA-YTYECPKG 323

Query: 674  LGITTDGRDINECALDPEVCANGV-CENLRGSYRCVCNLGYEAGASGKDCTDVDECALNS 732
                    D++E +L P  C NG  C  +     C+C+  +    +   C  +     + 
Sbjct: 324  SSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIF----TDLLCKSIQTSCESF 377

Query: 733  LLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC--LSSPCVSGV-CRNLAGSYTC 789
             L +N  C+     Y CSC  GF    +    K +D C  LS  C++   C N+ G +  
Sbjct: 378  PLRNNATCKKCEKDYPCSCISGF---TEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKY 434

Query: 790  KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCE-- 847
             C PG             TK  CW           L+   L  +     G  +   C+  
Sbjct: 435  VCIPG------------CTKNPCWF----------LKNVYLIHQHLCYCGVTFHGICQDK 472

Query: 848  -RCEIDPACARGFARMTGVTCDDVNECESF--PGVCPNGRCVNTAGSFRCEC---PEGLM 901
               + +     GFA   G  C  V +   F       +   VN        C    EG  
Sbjct: 473  GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK 532

Query: 902  -LDASGRLCVDVRLEP-----CFLRW------------DEDEC--GVTLPGKYRMDVCCC 941
             + A+G  C+           CFLRW             E+EC        +     C C
Sbjct: 533  EICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSC 592

Query: 942  S---IGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCT 998
            S   IG +  V  + C    S+    LC   L  +     SG   Y + N C++    C 
Sbjct: 593  SLSYIGRLCVVNVDYCLGNHSISVHGLC---LALSHNCNCSGLQRY-ERNICEIDTEDCK 648

Query: 999  HGTCRNTVGSFHC------ACAGGFALDAQERNCTDIDECRISPDLCGQG-TCVNTPGSF 1051
              +C+N   S H        C  GF     E    DIDEC   P  C  G TC++ PG++
Sbjct: 649  SASCKNGTTSTHLRGYFFRKCVPGFKGTQCE---IDIDECASHP--CKNGATCIDQPGNY 703

Query: 1052 ECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC 1111
             C+C P ++                              DG + C C PG+     G  C
Sbjct: 704  FCQCVPPFKV----------------------------VDG-FSCLCNPGY----VGIRC 730

Query: 1112 E-DIDECSLSDGLCPHGQ-CVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVH 1169
            E DID+C L+   C H   C ++  ++QC C + ++     Q   + NEC++     +  
Sbjct: 731  EQDIDDCILN--ACEHNSTCKDLHLSYQCVCLSDWEGNFCEQ---ESNECKMNPCKNNST 785

Query: 1170 CINTEGSYRCSCGQGYSLMPDGRACA-DVDECEENPRVCDQG---HCTNMPGGHRCLC-- 1223
            C +   SYRC C  G++    G+ C+ +++EC+ +P  C  G   H + +PG   CLC  
Sbjct: 786  CTDLYKSYRCECTSGWT----GQNCSEEINECDSDP--CMNGGLCHESTIPGQFVCLCPP 839

Query: 1224 -YDGFMATPDMRTC----------------VDVDE------------CDLNPHICL---- 1250
             Y G         C                VD ++            C+++   CL    
Sbjct: 840  LYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSC 899

Query: 1251 --HGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRC 1308
              +GDCE+   +F C C+ G+    G+    +++EC      C ++ +C+++   F C C
Sbjct: 900  QDYGDCEDMVNNFRCICRPGF---SGSLCEIEINEC--SSEPCKNNGTCVDLTNRFFCNC 954

Query: 1309 LPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECA 1367
             P + G   E  D+++C  +   C    +C+     Y C C  G+   G  CE + DEC 
Sbjct: 955  EPEYHGPFCEL-DVNKC--KISPCLDEENCVYRTDGYNCLCAPGYT--GINCEINLDECL 1009

Query: 1368 ENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFR 1427
                L D G C++    Y C+C+ GF  T     C+        N C  G C  L   + 
Sbjct: 1010 SEPCLHD-GVCIDGINHYTCDCKSGFFGTH----CETNANDCLSNPCLHGRCTELINEYP 1064

Query: 1428 CICNGGYELDRGGGNC-TDINECADPVNCIN-GVCINTPGSYLCSCPQDFELNPSGVGCV 1485
            C C    + D     C   IN+C   + C+N G C  +   + C CP+ +    +G  C 
Sbjct: 1065 CSC----DADGTSTQCKIKINDCTS-IPCMNEGFCQKSAHGFTCICPRGY----TGAYC- 1114

Query: 1486 DTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTL 1545
            +    NC                E+   +      C  G      C   P          
Sbjct: 1115 EKSIDNC-------------AEPELNSVICLNGGICVDGPGHTFDCRCLP---------- 1151

Query: 1546 CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICED 1605
                 GF      + + +   C   P L  G DC +    + C+C PG+  S H   CE+
Sbjct: 1152 -----GFSGQFCEININE---CSSSPCL-HGADCEDHINGYVCKCQPGW--SGHH--CEN 1198

Query: 1606 IDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMD-MRKSVC 1653
              EC  +S  C    C       TC+C   ++  + G  C D +R+  C
Sbjct: 1199 ELECIPNS--CVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITC 1245



 Score =  223 bits (569), Expect = 2e-57
 Identities = 284/1112 (25%), Positives = 424/1112 (38%), Gaps = 203/1112 (18%)

Query: 1008 SFHCACAGGFALDAQERNCTDI-DECRISPDLCGQGTCVN-TPGSFECECFPGYESGF-- 1063
            ++ C C   F      +NC++I  +C+  P +C  G C N T  SF CEC   +   F  
Sbjct: 239  AYECVCHPPFT----GKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCE 292

Query: 1064 MLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL 1123
            +  K C+ +       L  + G C N+  +Y  +CP G       T   D+ E SL    
Sbjct: 293  VSAKPCVSL-------LFWKRGICPNSSSAYTYECPKGSSSQNGET---DVSEFSLVP-- 340

Query: 1124 CPHG-QCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCG 1182
            C +G  C+ +     C C   F     +          ++N      C   E  Y CSC 
Sbjct: 341  CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNAT---CKKCEKDYPCSCI 397

Query: 1183 QGYSLMPDGRACADVDECEENPRVC-DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDE 1241
             G++     +A   +D C+     C ++  C N+ G  + +C  G    P    C  +  
Sbjct: 398  SGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNP----CWFLKN 450

Query: 1242 CDL-NPHIC-----LHGDCENT-KGSFVCHCQLGYMVRKG-------------ATGCSD- 1280
              L + H+C      HG C++     F    QLG+   +G             A  C++ 
Sbjct: 451  VYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTED 510

Query: 1281 ---VDECEVGGHNC-----------DSHASCLNIPGSFSCR--CLPGWVGDGFECHDLDE 1324
               V++ E    +C            +  SCL+   S   R  C   W G+ +  +  D+
Sbjct: 511  ATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDD 570

Query: 1325 CVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPG- 1383
               QE+ C     C +     RC+C   + G          C  NVD C     ++  G 
Sbjct: 571  ---QENECQHEAVCKDEINRPRCSCSLSYIGR--------LCVVNVDYCLGNHSISVHGL 619

Query: 1384 ----GYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRG 1439
                 + C C  G    E +    D ++C   +     +  +L G F   C  G++    
Sbjct: 620  CLALSHNCNCS-GLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFK---- 674

Query: 1440 GGNCT-DINECADPVNCINGV-CINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETH 1497
            G  C  DI+ECA    C NG  CI+ PG+Y C C   F++   G  C+      C     
Sbjct: 675  GTQCEIDIDECASHP-CKNGATCIDQPGNYFCQCVPPFKV-VDGFSCL------C----- 721

Query: 1498 DRGDSGISCSAEIGVGVTRA----SCCCSLGRAW----------------GNPCELCPMA 1537
            + G  GI C  +I   +  A    S C  L  ++                 N C++ P  
Sbjct: 722  NPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCK 781

Query: 1538 NTT-------EYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTF--GSFQC 1588
            N +        YR  C  G   Q        E+I+EC   P +  GG C  +   G F C
Sbjct: 782  NNSTCTDLYKSYRCECTSGWTGQN-----CSEEINECDSDPCM-NGGLCHESTIPGQFVC 835

Query: 1589 ECPP---GYHLSEHTRICEDIDECSTHSGICGPGTCYNTL-GNYTCVCPAEYLQVNGGNN 1644
             CPP   G    +   +C+ +     H+      TC   +  N  C+C  E+     G N
Sbjct: 836  LCPPLYTGQFCHQRYNLCDLL-----HNPCRNNSTCLALVDANQHCICREEF----EGKN 886

Query: 1645 CMDMRKSVCFRHYNGTCQNELAFNVTRKMC-------CCSYNIGQAWNRPCEACPTPISP 1697
            C    K   F         E   N  R +C        C   I +  + PC+   T +  
Sbjct: 887  CEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDL 946

Query: 1698 DYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSI 1757
              +  C N  P +         LD+++C   P +     C+ +   + C C  G+     
Sbjct: 947  TNRFFC-NCEPEYHGPFCE---LDVNKCKISPCLDEEN-CVYRTDGYNCLCAPGYTG--- 998

Query: 1758 LLACE-DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC-VGRNECREIPNV 1815
             + CE ++DEC S   PC  +  CI+    Y C C  G+    G  C    N+C  + N 
Sbjct: 999  -INCEINLDECLSE--PCLHDGVCIDGINHYTCDCKSGFF---GTHCETNANDC--LSNP 1050

Query: 1816 CSHGDCMDTEGSYMCLCHRGFQASADQTLC-MDIDECDRQPCGN-GTCKNIIGSYNCLCF 1873
            C HG C +    Y C C     A    T C + I++C   PC N G C+     + C+C 
Sbjct: 1051 CLHGRCTELINEYPCSC----DADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICP 1106

Query: 1874 PGFVVTHNGDCVDFDECTTLVGQVC-RFGHCLNTAG-SFHCLCQDGFELTADGKNC-VDT 1930
             G+   +    +D      L   +C   G C++  G +F C C  GF     G+ C ++ 
Sbjct: 1107 RGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS----GQFCEINI 1162

Query: 1931 NECLSLAGTCLPGT-CQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCT-NS 1988
            NEC S    CL G  C++    + C C PG+     HC +  EC   PN C+   C  N 
Sbjct: 1163 NECSS--SPCLHGADCEDHINGYVCKCQPGWS--GHHCENELECI--PNSCVHELCMENE 1216

Query: 1989 PGSFQCLCPPGFVLSDNGHRCFD-TRQSFCFT 2019
            PGS  CLC PGF+    G  C D  R+  C T
Sbjct: 1217 PGS-TCLCTPGFMTCSIGLLCGDEIRRITCLT 1247



 Score =  218 bits (556), Expect = 5e-56
 Identities = 306/1228 (24%), Positives = 472/1228 (38%), Gaps = 221/1228 (17%)

Query: 1034 ISPDLC-GQGTCVNTPGS--FECECFPGYESGFMLMKNCMDVDECARDPLLCRG-GTCTN 1089
            +S + C G G C++   S  + C C P +       K C ++D C+  P  C+  G+C N
Sbjct: 178  LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSG-----KYCQELDACSFKP--CKNNGSCIN 230

Query: 1090 T-----DGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIG-AFQCSCHAG 1143
                  + +Y+C C P    T K  + E I +C     +C HG C N+   +F C C   
Sbjct: 231  KRENWDEQAYECVCHP--PFTGKNCS-EIIGQCQ--PHVCFHGNCSNITSNSFICECDEQ 285

Query: 1144 FQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEEN 1203
            F                    G    C N+  +Y   C +G S         DV E    
Sbjct: 286  FSGPFCEVSAKPCVSLLFWKRGI---CPNSSSAYTYECPKGSSSQ---NGETDVSEFSLV 339

Query: 1204 PRVCDQG-HCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFV 1262
            P  C  G  C  +     C+C   F    D+        C+  P +  +  C+  +  + 
Sbjct: 340  P--CQNGTDCIKISNDVMCICSPIFT---DLLCKSIQTSCESFP-LRNNATCKKCEKDYP 393

Query: 1263 CHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDL 1322
            C C  G+  +        +D C++   NC +   C NI G F   C+PG   +   C  L
Sbjct: 394  CSCISGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKN--PCWFL 448

Query: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAP 1382
                            + +   + C C   F G    C+D+                  P
Sbjct: 449  KN--------------VYLIHQHLCYCGVTFHG---ICQDK-----------------GP 474

Query: 1383 GGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGN 1442
              +    ++GF  +E  + CQ V + A   L A            C  +  Y  D    N
Sbjct: 475  AQFEYVWQLGFAGSEGEK-CQGVID-AYFFLAA-----------NCTEDATYVNDPEDNN 521

Query: 1443 CTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLE-THDRGD 1501
                + C  P      +C N      CSC  + +       C    AGN +LE T D  +
Sbjct: 522  ----SSCWFPHEGTKEICANG-----CSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQE 572

Query: 1502 SGISCSAEIGVGVTRASCCCSL---GRAWGNPCELCPMANTTEYRTLC------PGGEGF 1552
            +     A     + R  C CSL   GR      + C   ++     LC          G 
Sbjct: 573  NECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGL 632

Query: 1553 QPNRITVILEDIDECQELPGLCQGG-DCVNTFGSFQCECPPGYHLSEHTRICE-DIDECS 1610
            Q     +   D ++C+     C+ G    +  G F  +C PG+  ++    CE DIDEC+
Sbjct: 633  QRYERNICEIDTEDCKS--ASCKNGTTSTHLRGYFFRKCVPGFKGTQ----CEIDIDECA 686

Query: 1611 THSGICGPG-TCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNV 1669
            +H   C  G TC +  GNY C C   +  V+G +        +C   Y G          
Sbjct: 687  SHP--CKNGATCIDQPGNYFCQCVPPFKVVDGFS-------CLCNPGYVG---------- 727

Query: 1670 TRKMCCCSYNIGQAWNRPCEACPT--PISPDYQILCGNQAPGFLTDIHTGKPLDIDECGE 1727
                  C  +I       CE   T   +   YQ +C +   G   +       + +EC  
Sbjct: 728  ----IRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCE------QESNECKM 777

Query: 1728 IPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADC--INIPG 1785
             P    N  C +   S+RCEC +G+   +     E+++EC S   PC     C    IPG
Sbjct: 778  NPC-KNNSTCTDLYKSYRCECTSGWTGQN---CSEEINECDS--DPCMNGGLCHESTIPG 831

Query: 1786 SYRCKCTRGYKLSPGGACVGR-NECREIPNVC-SHGDCMD-TEGSYMCLCHRGFQASADQ 1842
             + C C     L  G  C  R N C  + N C ++  C+   + +  C+C   F+    +
Sbjct: 832  QFVCLCP---PLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCE 888

Query: 1843 TLCMDIDECDRQPCGN-GTCKNIIGSYNCLCFPGFVVTHNGDC--VDFDECTTLVGQVCR 1899
               +D+ +C    C + G C++++ ++ C+C PGF    +G    ++ +EC++   + C+
Sbjct: 889  ---IDVKDCLFLSCQDYGDCEDMVNNFRCICRPGF----SGSLCEIEINECSS---EPCK 938

Query: 1900 -FGHCLNTAGSFHCLCQDGFELTADGKNC-VDTNECLSLAGTCL-PGTCQNLEGSFRCIC 1956
              G C++    F C C+  +     G  C +D N+C      CL    C      + C+C
Sbjct: 939  NNGTCVDLTNRFFCNCEPEYH----GPFCELDVNKC--KISPCLDEENCVYRTDGYNCLC 992

Query: 1957 PPGFQVQSDHC-IDIDECSEEPNLCLF-GTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQ 2014
             PG+     +C I++DEC  EP  CL  G C +    + C C  GF     G  C +T  
Sbjct: 993  APGY--TGINCEINLDECLSEP--CLHDGVCIDGINHYTCDCKSGFF----GTHC-ETNA 1043

Query: 2015 SFCFTR-FEAGKCS-----VPKAFNTTKTRCCCSKRPGEGWGDPC--ELCPQEGSAAFQE 2066
            + C +     G+C+      P + +   T   C  +  +    PC  E   Q+ +  F  
Sbjct: 1044 NDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTC 1103

Query: 2067 LCPFGH-GAVPGPDDSREDVNECAE---NPGVCTN-GVCVNTDG-SFRCECPFGYSLDFT 2120
            +CP G+ GA        + ++ CAE   N  +C N G+CV+  G +F C C  G+S  F 
Sbjct: 1104 ICPRGYTGAY-----CEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFC 1158

Query: 2121 GINCVDTDECSVGHPCGQGT-CTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAF 2179
             IN    +ECS   PC  G  C + I G+ C C  G+       CE+  EC  N  +   
Sbjct: 1159 EIN---INECS-SSPCLHGADCEDHINGYVCKCQPGWSG---HHCENELECIPNSCVHEL 1211

Query: 2180 RCHNTEGSYLCTCPAGYTLREDGAMCRD 2207
               N  GS  C C  G+     G +C D
Sbjct: 1212 CMENEPGS-TCLCTPGFMTCSIGLLCGD 1238



 Score =  197 bits (501), Expect = 1e-49
 Identities = 281/1109 (25%), Positives = 419/1109 (37%), Gaps = 225/1109 (20%)

Query: 1562 EDIDECQELPGLCQGGDCVN-TFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT 1620
            E I +CQ  P +C  G+C N T  SF CEC   +        CE   +          G 
Sbjct: 255  EIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFS----GPFCEVSAKPCVSLLFWKRGI 308

Query: 1621 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYN- 1679
            C N+   YT  CP      NG  +  +     C    NGT   +++ +V   MC CS   
Sbjct: 309  CPNSSSAYTYECPKGSSSQNGETDVSEFSLVPC---QNGTDCIKISNDV---MCICSPIF 362

Query: 1680 ---IGQAWNRPCEACPT-------PISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIP 1729
               + ++    CE+ P            DY   C     GF T+ +  K   ID C  + 
Sbjct: 363  TDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSC---ISGF-TEKNCEKA--IDHCKLLS 416

Query: 1730 AICANGI-CINQIGSFRCECPAGFNYN------SILLACEDVDECG-SRESPCQQNADCI 1781
              C N   C N IG F+  C  G   N      ++ L  + +  CG +    CQ      
Sbjct: 417  INCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKG--- 473

Query: 1782 NIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASAD 1841
              P  +      G+  S G  C G  +           +C + + +Y+           +
Sbjct: 474  --PAQFEYVWQLGFAGSEGEKCQGVIDAYFF----LAANCTE-DATYVN------DPEDN 520

Query: 1842 QTLCMDIDECDRQPCGNG-TCKNIIGS--YNCLCF---PGFVVTHNGDCVDFDECTTLVG 1895
             + C    E  ++ C NG +C +   S  Y  LCF    G +   N      +EC     
Sbjct: 521  NSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQ---- 576

Query: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV-DTNECLSLAGTCLPGTCQNLEGSFRC 1954
                   C +      C C     L+  G+ CV + + CL      + G C  L  S  C
Sbjct: 577  ---HEAVCKDEINRPRCSCS----LSYIGRLCVVNVDYCLGNHSISVHGLCLAL--SHNC 627

Query: 1955 ICPPGFQVQSDHC-IDIDECSEEPNLCLFGTC-TNSPGSFQCLCPPGFVLSDNGHRCFDT 2012
             C    + + + C ID ++C      C  GT  T+  G F   C PGF     G +C   
Sbjct: 628  NCSGLQRYERNICEIDTEDCKSAS--CKNGTTSTHLRGYFFRKCVPGF----KGTQC--- 678

Query: 2013 RQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQ-EGSAAFQELCPFG 2071
                     +  +C    A +  K    C  +PG  +   C+  P  +    F  LC  G
Sbjct: 679  -------EIDIDEC----ASHPCKNGATCIDQPGNYF---CQCVPPFKVVDGFSCLCNPG 724

Query: 2072 HGAVPGPDDSREDVNECAENPGVCT-NGVCVNTDGSFRCECPFGYSLDFTGINCV-DTDE 2129
            +  +       +D+++C  N   C  N  C +   S++C C      D+ G  C  +++E
Sbjct: 725  YVGIR----CEQDIDDCILN--ACEHNSTCKDLHLSYQCVC----LSDWEGNFCEQESNE 774

Query: 2130 CSVGHPC-GQGTCTNVIGGFECACADGFEPGLMMTC-EDIDECSLNPLLCAFRCHNTE-- 2185
            C + +PC    TCT++   + C C  G+       C E+I+EC  +P +    CH +   
Sbjct: 775  CKM-NPCKNNSTCTDLYKSYRCECTSGWTG---QNCSEEINECDSDPCMNGGLCHESTIP 830

Query: 2186 GSYLCTCPAGYTLREDGAM----------CRDVDEC---ADGQQDCHARGM--------- 2223
            G ++C CP  YT +               CR+   C    D  Q C  R           
Sbjct: 831  GQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEID 890

Query: 2224 -------------ECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQPDLCVN-GRC 2268
                         +C++++  F C+C PG      SG  C  + NEC ++P  C N G C
Sbjct: 891  VKDCLFLSCQDYGDCEDMVNNFRCICRPGF-----SGSLCEIEINECSSEP--CKNNGTC 943

Query: 2269 VNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAE---CC 2325
            V+    F C+C+  +       + +  +  PC  E               V R +   C 
Sbjct: 944  VDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDE------------ENCVYRTDGYNCL 991

Query: 2326 CGGGRGWGPRCEL---------------CPLPGTSAYRKLCPHGSGYTAEGRDVDECRML 2370
            C  G   G  CE+               C + G + Y   C  G   T    + ++C  L
Sbjct: 992  CAPGYT-GINCEINLDECLSEPCLHDGVC-IDGINHYTCDCKSGFFGTHCETNANDC--L 1047

Query: 2371 AHLCAHGECINSLGSFRCHCQAGYTPDATATTC-LDMDECSQVPKPCTFLCKNTKGSFLC 2429
            ++ C HG C   +  + C C A    D T+T C + +++C+ +P      C+ +   F C
Sbjct: 1048 SNPCLHGRCTELINEYPCSCDA----DGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTC 1103

Query: 2430 SCPRGYLLEEDGRTC-KDLDECTSRQHNCQF-----LCVNTVG-AFTCRCPPGFTQHHQA 2482
             CPRGY     G  C K +D C   + N        +CV+  G  F CRC PGF+   Q 
Sbjct: 1104 ICPRGY----TGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS--GQF 1157

Query: 2483 CFDN-DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG 2541
            C  N +ECS+   PC     C +    + C+C  G+    SGH CE+  EC  P+ C H 
Sbjct: 1158 CEININECSS--SPCLHGADCEDHINGYVCKCQPGW----SGHHCENELECI-PNSCVHE 1210

Query: 2542 -CQNQLGGYRCSCPQGFTQHSQWAQCVDE 2569
             C     G  C C  GF   S    C DE
Sbjct: 1211 LCMENEPGSTCLCTPGFMTCSIGLLCGDE 1239



 Score =  192 bits (488), Expect = 4e-48
 Identities = 259/1066 (24%), Positives = 390/1066 (36%), Gaps = 257/1066 (24%)

Query: 1734 NGICINQIGS--FRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINI-----PGS 1786
            +G C+++  S  + C C   F+       C+++D C  +  PC+ N  CIN        +
Sbjct: 186  HGKCLSEAWSKTYSCHCQPPFSGKY----CQELDACSFK--PCKNNGSCINKRENWDEQA 239

Query: 1787 YRCKCTRGYKLSPGGACVGRNECREI-----PNVCSHGDCMD-TEGSYMCLCHRGF---- 1836
            Y C C   +         G+N C EI     P+VC HG+C + T  S++C C   F    
Sbjct: 240  YECVCHPPF--------TGKN-CSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPF 290

Query: 1837 -------------------------------QASADQTLCMDIDECDRQPCGNGT-CKNI 1864
                                           + S+ Q    D+ E    PC NGT C  I
Sbjct: 291  CEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI 350

Query: 1865 IGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG 1924
                 C+C P F            E   L         C      + C C  GF      
Sbjct: 351  SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNAT----CKKCEKDYPCSCISGFT----E 402

Query: 1925 KNCVDT-NECLSLAGTCLPGT-CQNLEGSFRCICPPGFQVQSDHCIDIDECSEEP----- 1977
            KNC    + C  L+  CL    C N+ G F+ +C PG             C++ P     
Sbjct: 403  KNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG-------------CTKNPCWFLK 449

Query: 1978 -------NLC-----LFGTCTNS-PGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAG 2024
                   +LC       G C +  P  F+ +   GF  S+ G +C     ++ F    A 
Sbjct: 450  NVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSE-GEKCQGVIDAYFFL---AA 505

Query: 2025 KCSVPKAF-NTTKTRCCCSKRPGEGW----GDPCELCPQEGSAAFQELCPF---GHGAVP 2076
             C+    + N  +        P EG      + C    +E S  ++ LC     G+  + 
Sbjct: 506  NCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLE 565

Query: 2077 GPDDSRED-------------------------------VNECAENPGVCTNGVCVNTDG 2105
               D +E+                               V+ C  N  +  +G+C+    
Sbjct: 566  NTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLAL-- 623

Query: 2106 SFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCE 2165
            S  C C  G       I  +DT++C         T T++ G F   C  GF+      CE
Sbjct: 624  SHNCNCS-GLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKG---TQCE 679

Query: 2166 -DIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC------------RDVDECA 2212
             DIDEC+ +P      C +  G+Y C C   + +  DG  C            +D+D+C 
Sbjct: 680  IDIDECASHPCKNGATCIDQPGNYFCQCVPPFKV-VDGFSCLCNPGYVGIRCEQDIDDCI 738

Query: 2213 DGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQPDLCVNGR-CVN 2270
                +       CK+L  ++ CVC          G  C  + NEC   P  C N   C +
Sbjct: 739  ---LNACEHNSTCKDLHLSYQCVCLSDWE-----GNFCEQESNECKMNP--CKNNSTCTD 788

Query: 2271 TAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGG-- 2328
               S+RC+C  G+       E ++    PC       M   L   S    +  C C    
Sbjct: 789  LYKSYRCECTSGWTGQNCSEEINECDSDPC-------MNGGLCHESTIPGQFVCLCPPLY 841

Query: 2329 -GRGWGPRCELCPLPGTSAYRKLCPHGSGYTA--------------EGR----DVDECRM 2369
             G+    R  LC L         C + S   A              EG+    DV +C  
Sbjct: 842  TGQFCHQRYNLCDL-----LHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLF 896

Query: 2370 LAHLCA-HGECINSLGSFRCHCQAGYTPDATATTC-LDMDECSQVPKPCTFLCKNTKGSF 2427
            L+  C  +G+C + + +FRC C+ G++     + C ++++ECS  P      C +    F
Sbjct: 897  LS--CQDYGDCEDMVNNFRCICRPGFS----GSLCEIEINECSSEPCKNNGTCVDLTNRF 950

Query: 2428 LCSCPRGY---LLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACF 2484
             C+C   Y     E D   CK +  C   ++     CV     + C C PG+T  +  C 
Sbjct: 951  FCNCEPEYHGPFCELDVNKCK-ISPCLDEEN-----CVYRTDGYNCLCAPGYTGIN--CE 1002

Query: 2485 DN-DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNECDGPHRCQHG- 2541
             N DEC ++P  C   G C +    + C+C  GF     G  CE + N+C   + C HG 
Sbjct: 1003 INLDECLSEP--CLHDGVCIDGINHYTCDCKSGFF----GTHCETNANDCLS-NPCLHGR 1055

Query: 2542 CQNQLGGYRCSCPQGFTQHSQWAQC-VDENECALSPPTCGSASCRNTLGGFRCVCPSGFD 2600
            C   +  Y CSC    T      QC +  N+C  S P      C+ +  GF C+CP G+ 
Sbjct: 1056 CTELINEYPCSCDADGTS----TQCKIKINDCT-SIPCMNEGFCQKSAHGFTCICPRGYT 1110

Query: 2601 ---FDQALGGC--QEVDECAGRRGPCSYSCANTPG-GFLCGCPQGY 2640
                ++++  C   E++      G     C + PG  F C C  G+
Sbjct: 1111 GAYCEKSIDNCAEPELNSVICLNGGI---CVDGPGHTFDCRCLPGF 1153



 Score =  192 bits (487), Expect = 5e-48
 Identities = 267/1094 (24%), Positives = 388/1094 (35%), Gaps = 233/1094 (21%)

Query: 419  CLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNI-PGTYHCRCYPG 477
            C+N R      +Y C C+  +T     E I   +C    C HG+C NI   ++ C C   
Sbjct: 228  CINKRENWDEQAYECVCHPPFTGKNCSEIIG--QCQPHVCFHGNCSNITSNSFICECDEQ 285

Query: 478  FQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECAT 537
            F        C    +  VS      G C N+  ++   C  G   S +G+  V      +
Sbjct: 286  FSG----PFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKG-SSSQNGETDVSE---FS 337

Query: 538  STMCVNGV-CLNEDGSFSCLCKPGFLLAPGGHYCMDID-ECQTPGICVNGHCTNTEGSFR 595
               C NG  C+       C+C P F        C  I   C++  +  N  C   E  + 
Sbjct: 338  LVPCQNGTDCIKISNDVMCICSPIFT----DLLCKSIQTSCESFPLRNNATCKKCEKDYP 393

Query: 596  CQCLGGLA---------------------------VGTDGRVCVDTHVRSTCY-----GA 623
            C C+ G                             +G    VC+    ++ C+       
Sbjct: 394  CSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYL 453

Query: 624  IEKGSCARPFPGTVTKSECCCANPDH-------GF-GEPCQLCPAKDSAEF--QALCSSG 673
            I +  C   + G      C    P         GF G   + C     A F   A C+  
Sbjct: 454  IHQHLC---YCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTED 510

Query: 674  LGITTDGRDINECALDP-----EVCANG---VCENLRGSYRCVCNLGYEAGASGKDCTD- 724
                 D  D N     P     E+CANG   + E     YR +C L +      ++ TD 
Sbjct: 511  ATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDD 570

Query: 725  ----------------------------------VDECALNSLLCDNGWCQNSPGSYSCS 750
                                              VD C  N  +  +G C     S++C+
Sbjct: 571  QENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLAL--SHNCN 628

Query: 751  CPPGFHFWQ------DTEICK--------------------------------DVDECLS 772
            C  G   ++      DTE CK                                D+DEC S
Sbjct: 629  C-SGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECAS 687

Query: 773  SPCVSG-VCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLR 831
             PC +G  C +  G+Y C+C P  ++   G  CL      C       RCE ++      
Sbjct: 688  HPCKNGATCIDQPGNYFCQCVPPFKV-VDGFSCL------CNPGYVGIRCEQDI------ 734

Query: 832  SECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNECESFPGVCP-NGRCVNTA 889
             + C        S C+   +   C    +   G  C+ + NEC+  P  C  N  C +  
Sbjct: 735  -DDCILNACEHNSTCKDLHLSYQCV-CLSDWEGNFCEQESNECKMNP--CKNNSTCTDLY 790

Query: 890  GSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC-------GVTLPGKYRMDVCCCS 942
             S+RCEC  G     +G+ C +  +  C    D D C         T+PG++   VC C 
Sbjct: 791  KSYRCECTSGW----TGQNCSE-EINEC----DSDPCMNGGLCHESTIPGQF---VCLCP 838

Query: 943  ---IGAVWGVECEAC-----PDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFP 994
                G         C     P   +    +L         R+   G+    DV +C +F 
Sbjct: 839  PLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDC-LFL 897

Query: 995  GLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECE 1054
                +G C + V +F C C  GF+    E    +I+EC   P     GTCV+    F C 
Sbjct: 898  SCQDYGDCEDMVNNFRCICRPGFSGSLCE---IEINECSSEP-CKNNGTCVDLTNRFFCN 953

Query: 1055 CFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-D 1113
            C P Y   F      +DV++C   P L        TDG Y C C PG+     G  CE +
Sbjct: 954  CEPEYHGPFCE----LDVNKCKISPCLDEENCVYRTDG-YNCLCAPGY----TGINCEIN 1004

Query: 1114 IDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINT 1173
            +DEC LS+     G C++ I  + C C +GF  T       + N+C + N      C   
Sbjct: 1005 LDEC-LSEPCLHDGVCIDGINHYTCDCKSGFFGTHCE---TNANDC-LSNPCLHGRCTEL 1059

Query: 1174 EGSYRCSC-GQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPD 1232
               Y CSC   G S     +    +++C   P   ++G C     G  C+C  G+     
Sbjct: 1060 INEYPCSCDADGTST----QCKIKINDCTSIP-CMNEGFCQKSAHGFTCICPRGYTGAYC 1114

Query: 1233 MRTCVDVDECDLNPHICLHGD-CENTKG-SFVCHCQLGYMVRKGATGCSDVDECEVGGHN 1290
             ++  +  E +LN  ICL+G  C +  G +F C C  G+    G     +++EC      
Sbjct: 1115 EKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGF---SGQFCEININEC--SSSP 1169

Query: 1291 CDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCR 1350
            C   A C +    + C+C PGW   G  C +  EC+   + C       N PGS  C C 
Sbjct: 1170 CLHGADCEDHINGYVCKCQPGW--SGHHCENELECI--PNSCVHELCMENEPGS-TCLCT 1224

Query: 1351 QGF--AGDGFFCED 1362
             GF     G  C D
Sbjct: 1225 PGFMTCSIGLLCGD 1238



 Score =  136 bits (343), Expect = 3e-31
 Identities = 146/547 (26%), Positives = 210/547 (38%), Gaps = 92/547 (16%)

Query: 410  DICRHFTNLCL------NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDC 463
            + C   +N C       N  C     SYRCEC  G+T     E  +++EC S PC +G  
Sbjct: 766  NFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSE--EINECDSDPCMNGGL 823

Query: 464  VN---IPGTYHCRCYPGFQATPTRQACVD-VDECIVSGGLC-HLGRCVN-TEGSFQCVCN 517
             +   IPG + C C P +    T Q C    + C +    C +   C+   + +  C+C 
Sbjct: 824  CHESTIPGQFVCLCPPLY----TGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICR 879

Query: 518  AGFELSPDGKNC-VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC-MDIDE 575
              FE    GKNC +D  +C   +    G C +   +F C+C+PGF     G  C ++I+E
Sbjct: 880  EEFE----GKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGF----SGSLCEIEINE 931

Query: 576  CQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPG 635
            C +     NG C +    F C C         G  C     +      +++ +C     G
Sbjct: 932  CSSEPCKNNGTCVDLTNRFFCNC----EPEYHGPFCELDVNKCKISPCLDEENCVYRTDG 987

Query: 636  TVTKSECCCA----------NPDHGFGEPCQ---LCPAKDSAEFQALCSSGLGITTDGRD 682
                  C CA          N D    EPC    +C       +   C SG   T    +
Sbjct: 988  Y----NCLCAPGYTGINCEINLDECLSEPCLHDGVC-IDGINHYTCDCKSGFFGTHCETN 1042

Query: 683  INECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDN-GWCQ 741
             N+C  +P  C +G C  L   Y C C+     G S +    +++C   S+ C N G+CQ
Sbjct: 1043 ANDCLSNP--CLHGRCTELINEYPCSCDAD---GTSTQCKIKINDCT--SIPCMNEGFCQ 1095

Query: 742  NSPGSYSCSCPPGFHFWQDTEIC-KDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPS 800
             S   ++C CP G+        C K +D C      S +C N      C  GPG   D  
Sbjct: 1096 KSAHGFTCICPRGY----TGAYCEKSIDNCAEPELNSVICLN---GGICVDGPGHTFDCR 1148

Query: 801  GTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFA 860
               CL    G          CE+N+         C++     G+ CE   I+    +   
Sbjct: 1149 ---CLPGFSGQF--------CEININE-------CSSSPCLHGADCED-HINGYVCKCQP 1189

Query: 861  RMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVD-----VRLE 915
              +G  C+  NE E  P  C +  C+       C C  G M  + G LC D       L 
Sbjct: 1190 GWSGHHCE--NELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLT 1247

Query: 916  PCFLRWD 922
            P F R D
Sbjct: 1248 PIFQRTD 1254



 Score =  130 bits (327), Expect = 2e-29
 Identities = 179/752 (23%), Positives = 276/752 (36%), Gaps = 169/752 (22%)

Query: 112  CGVSRGSGCSVSCMNGGTC---RGASCL-CQKGYTGTVCGQPI---CDRGCHNGGRCIGP 164
            C +      S SC NG T    RG     C  G+ GT C   I       C NG  CI  
Sbjct: 640  CEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQ 699

Query: 165  N-----------------RCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTK 207
                               C C  G++G +CE+D     C        C+H  T      
Sbjct: 700  PGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDI--DDCI----LNACEHNSTCKDLHL 753

Query: 208  ALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNM 266
            +  C  +    G  CE                      Q+ +EC+  P  C+  S C ++
Sbjct: 754  SYQCVCLSDWEGNFCE----------------------QESNECKMNP--CKNNSTCTDL 789

Query: 267  VGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRC-AGDLAGHYTRRQCCCDRGRCW 325
              S+ C C  G    + S    +  +  C +   GG C    + G +           C 
Sbjct: 790  YKSYRCECTSGWTGQNCSEEINECDSDPCMN---GGLCHESTIPGQFV----------C- 835

Query: 326  AAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGS 385
                   LCPP  + +F   C QR  L          LL          L     N H  
Sbjct: 836  -------LCPPLYTGQF---CHQRYNLCD--------LLHNPCRNNSTCLALVDANQHCI 877

Query: 386  DARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLN-GRCLPTPSSYRCECNVGYTQDVR 444
                                N  ID+       C + G C    +++RC C  G++  + 
Sbjct: 878  CREEFEGK------------NCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSL- 924

Query: 445  GEC-IDVDECTSSPC-HHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHL 502
              C I+++EC+S PC ++G CV++   + C C P +         +DV++C +S  L   
Sbjct: 925  --CEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCE---LDVNKCKISPCLDE- 978

Query: 503  GRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVNGVCLNEDGSFSCLCKPGF 561
              CV     + C+C  G+     G NC ++ +EC +     +GVC++    ++C CK GF
Sbjct: 979  ENCVYRTDGYNCLCAPGYT----GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGF 1034

Query: 562  LLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCY 621
                G H   + ++C +   C++G CT     + C C        DG         ++  
Sbjct: 1035 F---GTHCETNANDCLS-NPCLHGRCTELINEYPCSC------DADG---------TSTQ 1075

Query: 622  GAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR 681
              I+   C          +   C N   GF   CQ    K +  F  +C  G       +
Sbjct: 1076 CKIKINDC----------TSIPCMN--EGF---CQ----KSAHGFTCICPRGYTGAYCEK 1116

Query: 682  DINECA---LDPEVCANG-VCENLRG-SYRCVCNLGYEAGASGKDCT-DVDECALNSLLC 735
             I+ CA   L+  +C NG +C +  G ++ C C  G+    SG+ C  +++EC+ +  L 
Sbjct: 1117 SIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGF----SGQFCEININECSSSPCL- 1171

Query: 736  DNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGS 795
                C++    Y C C PG   W     C++  EC+ + CV  +C       TC C PG 
Sbjct: 1172 HGADCEDHINGYVCKCQPG---WSGHH-CENELECIPNSCVHELCMENEPGSTCLCTPGF 1227

Query: 796  RLDPSGTFCLDSTKG-TCWLKIQESRCEVNLQ 826
                 G  C D  +  TC   I +    ++ Q
Sbjct: 1228 MTCSIGLLCGDEIRRITCLTPIFQRTDPISTQ 1259



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 143/626 (22%), Positives = 214/626 (34%), Gaps = 157/626 (25%)

Query: 103  CADGTLAPSCGVSRGSGCSVSCMNGGTC------------------RGASCLCQKGYTGT 144
            C  G     C +      S  C NG TC                   G SCLC  GY G 
Sbjct: 669  CVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGI 728

Query: 145  VCGQPICD---RGCHNGGRCIGPN---RCACVYGFMGPQCERDYRTGPCFGQVGPEGCQH 198
             C Q I D     C +   C   +   +C C+  + G  CE++  +  C  ++ P  C++
Sbjct: 729  RCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQE--SNEC--KMNP--CKN 782

Query: 199  QLTGLVCTKALCCATVGRAWGLPC--ELCPAQPHPCRRG--------------FIPNIHT 242
              T     K+  C       G  C  E+      PC  G                P ++T
Sbjct: 783  NSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYT 842

Query: 243  G--ACQDVDECQAVPGLCQGGS-CVNMV-GSFHCRCPVGHRLSDSS--------AACEDY 290
            G    Q  + C  +   C+  S C+ +V  + HC C       +           +C+DY
Sbjct: 843  GQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDY 902

Query: 291  RAGACFSVLFGGRC------AGDLAGHYTRRQCCCDRGRCWAAGPVPEL-------CPPR 337
              G C  ++   RC      +G L          C    C   G   +L       C P 
Sbjct: 903  --GDCEDMVNNFRCICRPGFSGSLCEIEINE---CSSEPCKNNGTCVDLTNRFFCNCEPE 957

Query: 338  GSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGN 397
                F +L   +  +    P L      + ++G      P                    
Sbjct: 958  YHGPFCELDVNKCKI---SPCLDEENCVYRTDGYNCLCAP-------------------- 994

Query: 398  SNIGTATLNQTIDICRHFTNLCL-NGRCLPTPSSYRCECNVGYTQDVRGEC-IDVDECTS 455
               G   +N  I++    +  CL +G C+   + Y C+C  G+       C  + ++C S
Sbjct: 995  ---GYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGF---FGTHCETNANDCLS 1048

Query: 456  SPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCV 515
            +PC HG C  +   Y C C     +T   Q  + +++C  S    + G C  +   F C+
Sbjct: 1049 NPCLHGRCTELINEYPCSCDADGTST---QCKIKINDC-TSIPCMNEGFCQKSAHGFTCI 1104

Query: 516  CNAGF-----ELSPDGKNCVDHNECATSTMCVN-GVCLNEDG-SFSCLCKPGF------- 561
            C  G+     E S D  NC +      S +C+N G+C++  G +F C C PGF       
Sbjct: 1105 CPRGYTGAYCEKSID--NCAEPE--LNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEI 1160

Query: 562  -------------------------LLAPG--GHYCMDIDECQTPGICVNGHCTNTEGSF 594
                                        PG  GH+C +  EC  P  CV+  C   E   
Sbjct: 1161 NINECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELEC-IPNSCVHELCMENEPGS 1219

Query: 595  RCQCLGGLAVGTDGRVCVDTHVRSTC 620
             C C  G    + G +C D   R TC
Sbjct: 1220 TCLCTPGFMTCSIGLLCGDEIRRITC 1245



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 118/482 (24%), Positives = 171/482 (35%), Gaps = 89/482 (18%)

Query: 101  CTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGAS------CLCQKGYTGTVCGQ--PICD 152
            C C  G    +C        S  CMNGG C  ++      CLC   YTG  C Q   +CD
Sbjct: 795  CECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD 854

Query: 153  ---RGCHNGGRCI----GPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVC 205
                 C N   C+        C C   F G  CE D +            C+  +    C
Sbjct: 855  LLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRC 914

Query: 206  ------TKALCCATVGRAWGLPCELCPAQPHPCRRGFI---PNIHTGACQ-DVDECQAVP 255
                  + +LC   +      PC+          R F    P  H   C+ DV++C+  P
Sbjct: 915  ICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISP 974

Query: 256  GLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYT-- 313
             L +  +CV     ++C C  G+   +     ++  +  C   L  G C  D   HYT  
Sbjct: 975  CLDE-ENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPC---LHDGVCI-DGINHYTCD 1029

Query: 314  -------------RRQCC---CDRGRCW-AAGPVPELCPPRGSNEFQQLCAQRLPLLPGH 356
                            C    C  GRC       P  C   G++     C  ++      
Sbjct: 1030 CKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTS---TQCKIKINDCTSI 1086

Query: 357  PGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRH-- 414
            P +  G     ++G         + P G                  A   ++ID C    
Sbjct: 1087 PCMNEGFCQKSAHGF------TCICPRGYTG---------------AYCEKSIDNCAEPE 1125

Query: 415  -FTNLCLNGR-CLPTPS-SYRCECNVGYTQDVRGEC-IDVDECTSSPCHHG-DCVNIPGT 469
              + +CLNG  C+  P  ++ C C  G++      C I+++EC+SSPC HG DC +    
Sbjct: 1126 LNSVICLNGGICVDGPGHTFDCRCLPGFSGQF---CEININECSSSPCLHGADCEDHING 1182

Query: 470  YHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC 529
            Y C+C PG+        C +  ECI +   C    C+  E    C+C  GF     G  C
Sbjct: 1183 YVCKCQPGWSG----HHCENELECIPNS--CVHELCMENEPGSTCLCTPGFMTCSIGLLC 1236

Query: 530  VD 531
             D
Sbjct: 1237 GD 1238



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 89/330 (26%), Positives = 113/330 (34%), Gaps = 84/330 (25%)

Query: 62   SRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPN---------LCTCADGTLAPSC 112
            + F   C PG   F G S C + I    C    C              C C      P C
Sbjct: 910  NNFRCICRPG---FSG-SLCEIEI--NECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFC 963

Query: 113  GVSRGSGCSVS-CMNGGTC----RGASCLCQKGYTGTVCG---QPICDRGCHNGGRCI-G 163
             +     C +S C++   C     G +CLC  GYTG  C           C + G CI G
Sbjct: 964  ELDVNK-CKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDG 1022

Query: 164  PNR--CACVYGFMGPQCERDYRT--------GPCFGQVGPEGCQHQLTGLVCTKALCCAT 213
             N   C C  GF G  CE +           G C   +    C     G   T   C   
Sbjct: 1023 INHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADG---TSTQCKIK 1079

Query: 214  VGRAWGLPC---ELCPAQPHP----CRRGFIPNIHTGA-CQ-DVDECQAVPGL-----CQ 259
            +     +PC     C    H     C RG+     TGA C+  +D C A P L       
Sbjct: 1080 INDCTSIPCMNEGFCQKSAHGFTCICPRGY-----TGAYCEKSIDNC-AEPELNSVICLN 1133

Query: 260  GGSCVNMVG-SFHCRCPVG----------HRLSDS----SAACEDYRAGACFSVLFGGRC 304
            GG CV+  G +F CRC  G          +  S S     A CED+  G      +  +C
Sbjct: 1134 GGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHING------YVCKC 1187

Query: 305  AGDLAGHYTRRQCCCDRGRCWAAGPVPELC 334
                +GH+   +  C    C     V ELC
Sbjct: 1188 QPGWSGHHCENELECIPNSC-----VHELC 1212



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 30/94 (31%), Positives = 48/94 (51%), Gaps = 10/94 (10%)

Query: 1274 GATGCSDVDECE---VGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEH 1330
            GA G S+V +C+    G + C +   C     +FSCRCLP W G+   C+    C++  +
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGN--TCNQSVSCLN--N 2919

Query: 1331 RCSPRGDCL-NVPGSYRCTCRQGFAGDGFFCEDR 1363
             C  +  C+ +   SY C C  G+ G   +CE++
Sbjct: 2920 LCLHQSLCIPDQSFSYSCLCTLGWVGR--YCENK 2951



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 46/181 (25%), Positives = 63/181 (34%), Gaps = 41/181 (22%)

Query: 124 CMNGGTCRGASCLCQKGYTGTVCGQ-PICD-RGCHNGGRCIGPN--------RCACVYGF 173
           C++    +  SC CQ  ++G  C +   C  + C N G CI            C C   F
Sbjct: 189 CLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPF 248

Query: 174 MGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPC- 232
            G  C          GQ  P  C H     + + +  C    +  G  CE+      PC 
Sbjct: 249 TGKNCSE------IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV---SAKPCV 299

Query: 233 -----RRGFIPN---IHTGAC----------QDVDECQAVPGLCQGGS-CVNMVGSFHCR 273
                +RG  PN    +T  C           DV E   VP  CQ G+ C+ +     C 
Sbjct: 300 SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCI 357

Query: 274 C 274
           C
Sbjct: 358 C 358



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 22/74 (29%), Positives = 31/74 (41%), Gaps = 6/74 (8%)

Query: 1291 CDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQE---HRCSPRGDCLNVPGSYRC 1347
            C +  +C+    S  C C  GW G  F    +  C  +    H CS    C+++P  Y C
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGS-FCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677

Query: 1348 TCRQGFAGDGFFCE 1361
             C  G    G +CE
Sbjct: 2678 FCPLGTT--GIYCE 2689



 Score = 42.0 bits (97), Expect = 0.009
 Identities = 22/64 (34%), Positives = 28/64 (43%), Gaps = 9/64 (14%)

Query: 124  CMNGGTC----RGASCLCQKGYTGTVCGQPICDRG-CHNGGRCIGPNR----CACVYGFM 174
            C N GTC        C C + Y+G +C    C+   C NG  C+  +     C C YG  
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRS 2403

Query: 175  GPQC 178
            GP C
Sbjct: 2404 GPLC 2407



 Score = 40.4 bits (93), Expect = 0.025
 Identities = 29/81 (35%), Positives = 34/81 (41%), Gaps = 14/81 (17%)

Query: 2488 ECSAQPGP---CGAHGHCHNTPGSFRCECHQGFTLVSSGHGC-EDVNECDG----PHRCQ 2539
            +C A P     CG  G C  +  S  C C  G+     G  C E V+ CD     PH C 
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGW----KGSFCTETVSTCDPEHDPPHHCS 2663

Query: 2540 HG--CQNQLGGYRCSCPQGFT 2558
             G  C +   GY C CP G T
Sbjct: 2664 RGATCISLPHGYTCFCPLGTT 2684



 Score = 38.9 bits (89), Expect = 0.072
 Identities = 31/98 (31%), Positives = 40/98 (40%), Gaps = 12/98 (12%)

Query: 1029 IDECRISPDL---CGQG-TCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLC-R 1083
            + +C  SP     CG G TC+ +  S  C C  G++  F   +     D     P  C R
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT-ETVSTCDPEHDPPHHCSR 2664

Query: 1084 GGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSD 1121
            G TC +    Y C CP G      G  CE     S+SD
Sbjct: 2665 GATCISLPHGYTCFCPLG----TTGIYCE--QALSISD 2696



 Score = 38.9 bits (89), Expect = 0.072
 Identities = 23/79 (29%), Positives = 30/79 (37%), Gaps = 12/79 (15%)

Query: 1719 PLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESP---CQ 1775
            P  + +CG        G CI    S  C C  G+  +      E V  C     P   C 
Sbjct: 2613 PCSLMKCGN------GGTCIESGTSVYCNCTTGWKGS---FCTETVSTCDPEHDPPHHCS 2663

Query: 1776 QNADCINIPGSYRCKCTRG 1794
            + A CI++P  Y C C  G
Sbjct: 2664 RGATCISLPHGYTCFCPLG 2682



 Score = 36.6 bits (83), Expect = 0.36
 Identities = 20/73 (27%), Positives = 26/73 (35%), Gaps = 19/73 (26%)

Query: 1331 RCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCD-----------NGQCL 1379
            +C   G C+    S  C C  G+ G          C E V  CD              C+
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSF--------CTETVSTCDPEHDPPHHCSRGATCI 2669

Query: 1380 NAPGGYRCECEMG 1392
            + P GY C C +G
Sbjct: 2670 SLPHGYTCFCPLG 2682



 Score = 36.2 bits (82), Expect = 0.47
 Identities = 19/66 (28%), Positives = 31/66 (46%), Gaps = 6/66 (9%)

Query: 1252 GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGG---HNCDSHASCLNIPGSFSCRC 1308
            G C  +  S  C+C  G+   KG+     V  C+      H+C   A+C+++P  ++C C
Sbjct: 2623 GTCIESGTSVYCNCTTGW---KGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFC 2679

Query: 1309 LPGWVG 1314
              G  G
Sbjct: 2680 PLGTTG 2685



 Score = 35.4 bits (80), Expect = 0.80
 Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 21/104 (20%)

Query: 503  GRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCL-------NEDGSFSC 555
            G C     +F C C       PD       N C  S  C+N +CL       ++  S+SC
Sbjct: 2888 GECTVNGTTFSCRC------LPDWAG----NTCNQSVSCLNNLCLHQSLCIPDQSFSYSC 2937

Query: 556  LCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCL 599
            LC  G++    G YC +     T     N +    + ++R + L
Sbjct: 2938 LCTLGWV----GRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNL 2977



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 22/74 (29%), Positives = 30/74 (40%), Gaps = 11/74 (14%)

Query: 117  GSGCSVS-CMNGGTCR----GASCLCQKGYTGTVCGQPIC--DRGCHNGGRCIGPNR--- 166
            G+ C  + C NGG C       SC C   + G  C Q +   +  C +   CI       
Sbjct: 2876 GTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSY 2935

Query: 167  -CACVYGFMGPQCE 179
             C C  G++G  CE
Sbjct: 2936 SCLCTLGWVGRYCE 2949



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 14/95 (14%)

Query: 2071 GHGAVPGPDDSREDVNECAENPGV---CTNG-VCVNTDGSFRCECPFGYSLDFTGINCVD 2126
            G G   G  ++   V +C  +P     C NG  C+ +  S  C C  G+   F    C +
Sbjct: 2592 GLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSF----CTE 2647

Query: 2127 T-----DECSVGHPCGQG-TCTNVIGGFECACADG 2155
            T      E    H C +G TC ++  G+ C C  G
Sbjct: 2648 TVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG 2682



 Score = 34.3 bits (77), Expect = 1.8
 Identities = 18/69 (26%), Positives = 27/69 (39%), Gaps = 4/69 (5%)

Query: 422  GRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHH----GDCVNIPGTYHCRCYPG 477
            G C+ + +S  C C  G+      E +   +    P HH      C+++P  Y C C  G
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG 2682

Query: 478  FQATPTRQA 486
                   QA
Sbjct: 2683 TTGIYCEQA 2691



 Score = 33.5 bits (75), Expect = 3.0
 Identities = 19/59 (32%), Positives = 23/59 (38%), Gaps = 1/59 (1%)

Query: 1576 GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPG-TCYNTLGNYTCVCP 1633
            GG C+ +  S  C C  G+  S  T      D        C  G TC +    YTC CP
Sbjct: 2622 GGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCP 2680



 Score = 33.5 bits (75), Expect = 3.0
 Identities = 26/102 (25%), Positives = 43/102 (42%), Gaps = 14/102 (13%)

Query: 445  GECIDVDECTSSPCHHGDCVNIPGT-YHCRCYPGFQATPTRQACVDVDECIVSGGLC-HL 502
            G+C D   C  + C +G    + GT + CRC P +      Q+      C+    LC H 
Sbjct: 2872 GDC-DGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV----SCL--NNLCLHQ 2924

Query: 503  GRCVNTEG-SFQCVCNAGFELSPDGKNCVDHNECATSTMCVN 543
              C+  +  S+ C+C  G+     G+ C +    +T+    N
Sbjct: 2925 SLCIPDQSFSYSCLCTLGWV----GRYCENKTSFSTAKFMGN 2962



 Score = 32.3 bits (72), Expect = 6.8
 Identities = 28/114 (24%), Positives = 38/114 (33%), Gaps = 35/114 (30%)

Query: 1358 FFCEDRDECAENVDLC-----------DNGQCLNAPGGYRCECEMGFDPTEDHRACQDVD 1406
            FF  D     +N++ C           +NG C++      CEC   +             
Sbjct: 2319 FFIIDEARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYS------------ 2366

Query: 1407 ECAQGNLCAFGSCENLP--GMFRCICNGGYEL------DRGGGNCTDINECADP 1452
                G LC F SCEN P      C+   G ++       R G  CTD      P
Sbjct: 2367 ----GKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416



 Score = 32.3 bits (72), Expect = 6.8
 Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 12/66 (18%)

Query: 1163 NGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD-VDECE---ENPRVCDQGH-CTNMPG 1217
            NGG    CI +  S  C+C  G+     G  C + V  C+   + P  C +G  C ++P 
Sbjct: 2621 NGGT---CIESGTSVYCNCTTGWK----GSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673

Query: 1218 GHRCLC 1223
            G+ C C
Sbjct: 2674 GYTCFC 2679



 Score = 32.3 bits (72), Expect = 6.8
 Identities = 22/74 (29%), Positives = 30/74 (40%), Gaps = 14/74 (18%)

Query: 1417 GSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVN-----CINGV-CINTPGSYLCS 1470
            G+C        C C  G++    G  CT+     DP +     C  G  CI+ P  Y C 
Sbjct: 2623 GTCIESGTSVYCNCTTGWK----GSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCF 2678

Query: 1471 CPQDFELNPSGVGC 1484
            CP    L  +G+ C
Sbjct: 2679 CP----LGTTGIYC 2688



 Score = 32.0 bits (71), Expect = 8.8
 Identities = 16/59 (27%), Positives = 26/59 (44%), Gaps = 4/59 (6%)

Query: 2097 NGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADG 2155
            NG C++ + +  CECP  YS         + + C  G  C   + T+++    C C  G
Sbjct: 2347 NGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIV----CLCPYG 2401



 Score = 32.0 bits (71), Expect = 8.8
 Identities = 23/85 (27%), Positives = 30/85 (35%), Gaps = 6/85 (7%)

Query: 2356 GYTAEGRDVDECRM----LAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQ 2411
            G+   GR V +C      L      G CI S  S  C+C  G+       T    D    
Sbjct: 2598 GHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHD 2657

Query: 2412 VPKPCT--FLCKNTKGSFLCSCPRG 2434
             P  C+    C +    + C CP G
Sbjct: 2658 PPHHCSRGATCISLPHGYTCFCPLG 2682


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  217 bits (552), Expect = 1e-55
 Identities = 210/778 (26%), Positives = 311/778 (39%), Gaps = 160/778 (20%)

Query: 939  CCCSIGAVW-GVECEAC-PDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGL 996
            C C  G  W G+ C+ C P P  +    +C             G+   KD+N C      
Sbjct: 251  CRCQYG--WQGLYCDKCIPHPGCVH--GICNEPWQCLCETNWGGQLCDKDLNYCGTHQPC 306

Query: 997  CTHGTCRNT-VGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECEC 1055
               GTC NT    + C+C  G++      NC   +   +S     +G+C  T   FECEC
Sbjct: 307  LNGGTCSNTGPDKYQCSCPEGYS----GPNCEIAEHACLSDPCHNRGSCKETSLGFECEC 362

Query: 1056 FPGYESGFMLMKNC-MDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACED 1113
             PG+         C  ++D+C+  P  C  GGTC +    +KC CPP  + T K T   D
Sbjct: 363  SPGWTG-----PTCSTNIDDCS--PNNCSHGGTCQDLVNGFKCVCPP--QWTGK-TCQLD 412

Query: 1114 IDECSLSDGLCPHGQ-CVNVIGAFQCSCHAGFQSTPDRQGC-VDINEC--RVQNGGCDVH 1169
             +EC      C + + C N+I ++ C C  G+      Q C ++IN+C  + QN   D  
Sbjct: 413  ANECEAKP--CVNAKSCKNLIASYYCDCLPGWMG----QNCDININDCLGQCQN---DAS 463

Query: 1170 CINTEGSYRCSCGQGYSLMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFM 1228
            C +    YRC C  GY+    G  C  D+DEC  NP   + GHC N     +CLC  GF 
Sbjct: 464  CRDLVNGYRCICPPGYA----GDHCERDIDECASNP-CLNGGHCQNEINRFQCLCPTGFS 518

Query: 1229 ATPDMRTC-VDVDECDLNPHICLHG-DCENTKGSFVCHCQLGYMVRK--------GATGC 1278
                   C +D+D C+ NP  C +G  C N    + C C   Y  +           T C
Sbjct: 519  G----NLCQLDIDYCEPNP--CQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPC 572

Query: 1279 SDVDECEV--------------GGHNCDSHASCLN-IPGSFSCRCLPGWVGDGFECHD-L 1322
              +D C V                + C  H  C +   G F+C C  G+ G    CH+ +
Sbjct: 573  EVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGT--YCHENI 630

Query: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDR-DECAENVDLCDN-GQCLN 1380
            ++C  + + C   G C++   SY+C C  G+  +G +CE   ++C++N   C N G C +
Sbjct: 631  NDC--ESNPCRNGGTCIDGVNSYKCICSDGW--EGAYCETNINDCSQNP--CHNGGTCRD 684

Query: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1440
                + C+C+ G+     H      DE    N    G+C +    F+C+C GG+E    G
Sbjct: 685  LVNDFYCDCKNGWKGKTCHSRDSQCDEATCNN---GGTCYDEGDAFKCMCPGGWE----G 737

Query: 1441 GNCTDI-NECADPVNCIN-GVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHD 1498
              C    N    P  C N G C+    S+ C C + +E    G  C      +C    H 
Sbjct: 738  TTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWE----GPICAQ-NTNDC--SPHP 790

Query: 1499 RGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRIT 1558
              +SG                 C  G  W              YR  C  G      RI 
Sbjct: 791  CYNSG----------------TCVDGDNW--------------YRCECAPGFAGPDCRI- 819

Query: 1559 VILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI------------ 1606
                +I+ECQ  P    G  CV+    ++C CPPG+  ++    C+++            
Sbjct: 820  ----NINECQSSP-CAFGATCVDEINGYRCVCPPGHSGAK----CQEVSGRPCITMGSVI 870

Query: 1607 -------DECSTHSGICGPGTCYNT-LGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRH 1656
                   D+C+T   + G   C     G   C+    + +   G +C+ +    CF H
Sbjct: 871  PDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVH 928



 Score =  215 bits (548), Expect = 4e-55
 Identities = 233/846 (27%), Positives = 329/846 (38%), Gaps = 174/846 (20%)

Query: 1067 KNCMDV---DECARDPLLCRGGTCTNTDGSYK----CQCPPGHELTAKGTACEDIDECSL 1119
            K CM+     EC R   +CR G C+   GS K    C+C  G +    G  C   D+C  
Sbjct: 218  KTCMEGWMGPECNR--AICRQG-CSPKHGSCKLPGDCRCQYGWQ----GLYC---DKCIP 267

Query: 1120 SDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC-VDINECRVQ----NGGCDVHCINT- 1173
              G C HG C      +QC C   +      Q C  D+N C       NGG    C NT 
Sbjct: 268  HPG-CVHGICNE---PWQCLCETNWGG----QLCDKDLNYCGTHQPCLNGGT---CSNTG 316

Query: 1174 EGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDM 1233
               Y+CSC +GYS    G  C   +    +    ++G C     G  C C  G+      
Sbjct: 317  PDKYQCSCPEGYS----GPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGP--- 369

Query: 1234 RTC-VDVDECDLNPHICLHGD-CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNC 1291
             TC  ++D+C  +P+ C HG  C++    F C C   +    G T   D +ECE     C
Sbjct: 370  -TCSTNIDDC--SPNNCSHGGTCQDLVNGFKCVCPPQWT---GKTCQLDANECEA--KPC 421

Query: 1292 DSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQ 1351
             +  SC N+  S+ C CLPGW+G   +  ++++C+ Q   C     C ++   YRC C  
Sbjct: 422  VNAKSCKNLIASYYCDCLPGWMGQNCDI-NINDCLGQ---CQNDASCRDLVNGYRCICPP 477

Query: 1352 GFAGDGFFCE-DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ-DVDECA 1409
            G+AGD   CE D DECA N  L + G C N    ++C C  GF        CQ D+D C 
Sbjct: 478  GYAGD--HCERDIDECASNPCL-NGGHCQNEINRFQCLCPTGF----SGNLCQLDIDYC- 529

Query: 1410 QGNLCAFGS-CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYL 1468
            + N C  G+ C N    + C C   YE    G NC+ + +           C  TP   +
Sbjct: 530  EPNPCQNGAQCYNRASDYFCKCPEDYE----GKNCSHLKD----------HCRTTPCEVI 575

Query: 1469 CSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG 1528
             SC      N +  G     +  C      +  SG   + +   G T   C  ++     
Sbjct: 576  DSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCES 635

Query: 1529 NPCE---LCPMANTTEYRTLCPGG-EGFQPNRITVILEDIDECQELPGLCQGGDCVNTFG 1584
            NPC     C +     Y+ +C  G EG           +I++C + P    GG C +   
Sbjct: 636  NPCRNGGTC-IDGVNSYKCICSDGWEG------AYCETNINDCSQNP-CHNGGTCRDLVN 687

Query: 1585 SFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644
             F C+C  G+            DE + ++G    GTCY+    + C+CP  +     G  
Sbjct: 688  DFYCDCKNGWKGKTCHSRDSQCDEATCNNG----GTCYDEGDAFKCMCPGGW----EGTT 739

Query: 1645 CMDMRKSVCFR---HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQI 1701
            C   R S C     H  GTC      N     C C     + W  P              
Sbjct: 740  CNIARNSSCLPNPCHNGGTC----VVNGESFTCVCK----EGWEGP-------------- 777

Query: 1702 LCGNQAPGFLTDIHTGKPLDIDECGEIPAICAN-GICINQIGSFRCECPAGFNYNSILLA 1760
            +C                 + ++C   P  C N G C++    +RCEC  GF      + 
Sbjct: 778  ICAQ---------------NTNDCSPHP--CYNSGTCVDGDNWYRCECAPGFAGPDCRI- 819

Query: 1761 CEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC--VGRNECREIPNVCSH 1818
              +++EC S  SPC   A C++    YRC C  G+    G  C  V    C  + +V   
Sbjct: 820  --NINECQS--SPCAFGATCVDEINGYRCVCPPGHS---GAKCQEVSGRPCITMGSVIPD 872

Query: 1819 G-----DCMDTE-------------GSYMCLCHRGFQASADQTLCMDI--DECDRQPC-G 1857
            G     DC   +             G   CL H+G         C+ I  D+C   PC G
Sbjct: 873  GAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTG 932

Query: 1858 NGTCKN 1863
             G C++
Sbjct: 933  VGECRS 938



 Score =  206 bits (525), Expect = 2e-52
 Identities = 236/861 (27%), Positives = 350/861 (40%), Gaps = 144/861 (16%)

Query: 1911 HCLC-QDGFELTADGKNCVDTNECLSLAGTCLP--GTCQNLEGSFRCICPPGFQVQSDHC 1967
            H  C Q+G +   +G    + N  +   G C P  G+C+ L G  RC     +  Q  +C
Sbjct: 209  HYACDQNGNKTCMEGWMGPECNRAICRQG-CSPKHGSCK-LPGDCRC----QYGWQGLYC 262

Query: 1968 IDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTR---FEAG 2024
               D+C   P  C+ G C N P  +QCLC   +     G +  D   ++C T       G
Sbjct: 263  ---DKCIPHPG-CVHGIC-NEP--WQCLCETNW-----GGQLCDKDLNYCGTHQPCLNGG 310

Query: 2025 KCSVPKAFNT--TKTRCCCSKRPGEGWGDP-CEL---------CPQEGSAAFQEL---CP 2069
             CS     NT   K +C C     EG+  P CE+         C   GS     L   C 
Sbjct: 311  TCS-----NTGPDKYQCSCP----EGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECE 361

Query: 2070 FGHGAVPGPDDSREDVNECAENPGVCTNG-VCVNTDGSFRCECPFGYSLDFTGINC-VDT 2127
               G   GP  S  ++++C+  P  C++G  C +    F+C CP      +TG  C +D 
Sbjct: 362  CSPGWT-GPTCST-NIDDCS--PNNCSHGGTCQDLVNGFKCVCP----PQWTGKTCQLDA 413

Query: 2128 DECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNPLLCAFRCHNTEG 2186
            +EC         +C N+I  + C C  G+   +   C+ +I++C L        C +   
Sbjct: 414  NECEAKPCVNAKSCKNLIASYYCDCLPGW---MGQNCDININDC-LGQCQNDASCRDLVN 469

Query: 2187 SYLCTCPAGYTLREDGAMC-RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPG 2245
             Y C CP GY     G  C RD+DECA     C   G  C+N I  F C+CP G      
Sbjct: 470  GYRCICPPGYA----GDHCERDIDECASNP--C-LNGGHCQNEINRFQCLCPTGF----- 517

Query: 2246 SGEGCTDDNECHAQPDLCVNG-RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEV 2304
            SG  C  D + + +P+ C NG +C N A  + C C E ++           R  PC    
Sbjct: 518  SGNLCQLDID-YCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVID 576

Query: 2305 LQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAE--GR 2362
              T+  + + + E V        G  G   +C+       S  +  C    G+T      
Sbjct: 577  SCTVAMASNDTPEGVRYISSNVCGPHG---KCK-----SQSGGKFTCDCNKGFTGTYCHE 628

Query: 2363 DVDECRMLAHLCAHG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCK 2421
            ++++C   ++ C +G  CI+ + S++C C  G+      T   ++++CSQ P      C+
Sbjct: 629  NINDCE--SNPCRNGGTCIDGVNSYKCICSDGWEGAYCET---NINDCSQNPCHNGGTCR 683

Query: 2422 NTKGSFLCSCPRGYLLEEDGRTCKDLD-ECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH 2480
            +    F C C  G+     G+TC   D +C     N    C +   AF C CP G+    
Sbjct: 684  DLVNDFYCDCKNGW----KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGW--EG 737

Query: 2481 QACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGC-EDVNECDGPHRCQ 2539
              C      S  P PC   G C     SF C C +G+     G  C ++ N+C  PH C 
Sbjct: 738  TTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGW----EGPICAQNTNDCS-PHPCY 792

Query: 2540 HG--CQNQLGGYRCSCPQGFTQHSQWAQC-VDENECALSPPTCGSASCRNTLGGFRCVCP 2596
            +   C +    YRC C  GF        C ++ NEC  SP   G A+C + + G+RCVCP
Sbjct: 793  NSGTCVDGDNWYRCECAPGFAG----PDCRININECQSSPCAFG-ATCVDEINGYRCVCP 847

Query: 2597 SGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGF-------LCGCPQGYFR-----AG 2644
             G     +   CQEV   +GR  PC    +  P G         C C  G         G
Sbjct: 848  PG----HSGAKCQEV---SGR--PCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCG 898

Query: 2645 QGHCVSGLGFSPGPQD---TPDKEELLSSEACY---ECKINGLSP--RDRPRRSAHRDHQ 2696
               C+   G S  P      P  ++      C    EC+ + L P        S ++D+ 
Sbjct: 899  PRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNC 958

Query: 2697 VNLATLDSEALLTLGLNLSHL 2717
             N+    ++ +++ GL   H+
Sbjct: 959  ANITFTFNKEMMSPGLTTEHI 979



 Score =  169 bits (429), Expect = 3e-41
 Identities = 210/856 (24%), Positives = 324/856 (37%), Gaps = 181/856 (21%)

Query: 609  RVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGF-GEPCQLCPAKDSA--- 664
            + C++  +   C  AI +  C+          +C C    +G+ G  C  C         
Sbjct: 218  KTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRC---QYGWQGLYCDKCIPHPGCVHG 274

Query: 665  ----EFQALCSSGLGITTDGRDINECALDPEVCANGVCENLR-GSYRCVCNLGYEAGASG 719
                 +Q LC +  G     +D+N C         G C N     Y+C C  GY    SG
Sbjct: 275  ICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGY----SG 330

Query: 720  KDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCV-SG 778
             +C   +   L+    + G C+ +   + C C PG   W       ++D+C  + C   G
Sbjct: 331  PNCEIAEHACLSDPCHNRGSCKETSLGFECECSPG---WTGPTCSTNIDDCSPNNCSHGG 387

Query: 779  VCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGAS----LRSEC 834
             C++L   + C C P              T  TC L   E   +  +   S    + S  
Sbjct: 388  TCQDLVNGFKCVCPP------------QWTGKTCQLDANECEAKPCVNAKSCKNLIASYY 435

Query: 835  CATLGAAWGSPCE--------RCEIDPAC---ARGFARM-----TGVTCD-DVNECESFP 877
            C  L    G  C+        +C+ D +C     G+  +      G  C+ D++EC S P
Sbjct: 436  CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP 495

Query: 878  GVCPN-GRCVNTAGSFRCECPEGLMLDASGRLC-VDV-RLEP--------CFLRWDEDEC 926
              C N G C N    F+C CP G     SG LC +D+   EP        C+ R  +  C
Sbjct: 496  --CLNGGHCQNEINRFQCLCPTGF----SGNLCQLDIDYCEPNPCQNGAQCYNRASDYFC 549

Query: 927  GVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKD 986
                P  Y    C           CE          ++  P G+ + S            
Sbjct: 550  --KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISS----------- 596

Query: 987  VNECKVFPGLCTHGTCRN-TVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCV 1045
             N C        HG C++ + G F C C  GF       N   I++C  +P   G GTC+
Sbjct: 597  -NVCG------PHGKCKSQSGGKFTCDCNKGFTGTYCHEN---INDCESNPCRNG-GTCI 645

Query: 1046 NTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELT 1105
            +   S++C C  G+E  +       ++++C+++P    GGTC +    + C C  G    
Sbjct: 646  DGVNSYKCICSDGWEGAYCE----TNINDCSQNP-CHNGGTCRDLVNDFYCDCKNGW--- 697

Query: 1106 AKGTAC----EDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTP---DRQGCVDINE 1158
             KG  C       DE + ++G    G C +   AF+C C  G++ T     R      N 
Sbjct: 698  -KGKTCHSRDSQCDEATCNNG----GTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNP 752

Query: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACA-DVDECEENPRVCDQGHCTNMPG 1217
            C   NGG    C+    S+ C C +G+    +G  CA + ++C  +P   + G C +   
Sbjct: 753  C--HNGGT---CVVNGESFTCVCKEGW----EGPICAQNTNDCSPHP-CYNSGTCVDGDN 802

Query: 1218 GHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHG-DCENTKGSFVCHCQLGYMVRKGAT 1276
             +RC C  GF A PD R  ++++EC  +P  C  G  C +    + C C  G+   K   
Sbjct: 803  WYRCECAPGF-AGPDCR--ININECQSSP--CAFGATCVDEINGYRCVCPPGHSGAK--- 854

Query: 1277 GCSDVDECEVGGHNCDSHASCLNIPGSF-----SCRCLPG-------WVG--------DG 1316
             C      EV G  C +  S +     +     +C+CL G       W G          
Sbjct: 855  -CQ-----EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGH 908

Query: 1317 FECHDLDECV------SQEHRCSPRGDCLN---VPGSYRCTCRQGFAGDGFFCEDRDECA 1367
             EC     C+         H C+  G+C +    P   +CT       D ++   +D CA
Sbjct: 909  SECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCT------SDSYY---QDNCA 959

Query: 1368 ENVDLCDNGQCLNAPG 1383
             N+    N + + +PG
Sbjct: 960  -NITFTFNKEMM-SPG 973



 Score =  168 bits (426), Expect = 6e-41
 Identities = 217/818 (26%), Positives = 302/818 (36%), Gaps = 206/818 (25%)

Query: 499  LCHLGRCVNTEGSFQ----CVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFS 554
            +C  G C    GS +    C C  G++    G  C   ++C     CV+G+C NE   + 
Sbjct: 233  ICRQG-CSPKHGSCKLPGDCRCQYGWQ----GLYC---DKCIPHPGCVHGIC-NEP--WQ 281

Query: 555  CLCKPGFLLAPGGHYC-MDIDECQTPGICVN-GHCTNT-EGSFRCQCLGGLAVGTDGRVC 611
            CLC+  +    GG  C  D++ C T   C+N G C+NT    ++C C  G + G +  + 
Sbjct: 282  CLCETNW----GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYS-GPNCEIA 336

Query: 612  VDTHVRSTCYGAIEKGSCARPF-------------PGTVTKSECC--------------- 643
                +   C+    +GSC                 P   T  + C               
Sbjct: 337  EHACLSDPCH---NRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLV 393

Query: 644  ----CANPDHGFGEPCQL----CPAKDS----------AEFQALCSSGLGITTDGRDINE 685
                C  P    G+ CQL    C AK            A +   C  G        +IN+
Sbjct: 394  NGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD 453

Query: 686  CALDPEVCANGV-CENLRGSYRCVCNLGYEAGASGKDC-TDVDECALNSLLCDNGWCQNS 743
            C      C N   C +L   YRC+C  GY    +G  C  D+DECA N  L + G CQN 
Sbjct: 454  CL---GQCQNDASCRDLVNGYRCICPPGY----AGDHCERDIDECASNPCL-NGGHCQNE 505

Query: 744  PGSYSCSCPPGFHFWQDTEICK-DVDECLSSPCVSGV-CRNLAGSYTCKCGPGSRLDPSG 801
               + C CP GF       +C+ D+D C  +PC +G  C N A  Y CKC      D  G
Sbjct: 506  INRFQCLCPTGF----SGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPE----DYEG 557

Query: 802  TFCLDSTKGTCWLKIQESRCEV----NLQGAS---------LRSECCATLGAAWGSPCER 848
              C    K  C    + + CEV     +  AS         + S  C   G        +
Sbjct: 558  KNC-SHLKDHC----RTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK 612

Query: 849  CEIDPACARGFARMTGVTC-DDVNECESFPGVCPN-GRCVNTAGSFRCECPEGLMLDASG 906
               D  C +GF   TG  C +++N+CES P  C N G C++   S++C C +G      G
Sbjct: 613  FTCD--CNKGF---TGTYCHENINDCESNP--CRNGGTCIDGVNSYKCICSDGW----EG 661

Query: 907  RLCVDVRLEPCFLRWDEDEC--GVTLPGKYRMDVCCCSIGAVW-GVECEA---------- 953
              C +  +  C     ++ C  G T         C C  G  W G  C +          
Sbjct: 662  AYC-ETNINDC----SQNPCHNGGTCRDLVNDFYCDCKNG--WKGKTCHSRDSQCDEATC 714

Query: 954  -----CPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTH-GTCRNTVG 1007
                 C D E   F  +CP G    + +                 P  C + GTC     
Sbjct: 715  NNGGTCYD-EGDAFKCMCPGGWEGTTCNI---------ARNSSCLPNPCHNGGTCVVNGE 764

Query: 1008 SFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTCVNTPGSFECECFPGYESGFMLM 1066
            SF C C  G+      +N  D      SP  C   GTCV+    + CEC PG+       
Sbjct: 765  SFTCVCKEGWEGPICAQNTND-----CSPHPCYNSGTCVDGDNWYRCECAPGFAG----- 814

Query: 1067 KNC-MDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDID--ECSLSDGL 1123
             +C ++++EC   P    G TC +    Y+C CPPGH     G  C+++    C     +
Sbjct: 815  PDCRININECQSSP-CAFGATCVDEINGYRCVCPPGH----SGAKCQEVSGRPCITMGSV 869

Query: 1124 CPHG----------QCVN--------VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG 1165
             P G          QC+N          G   C  H G    P  Q C+ I + +     
Sbjct: 870  IPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQ----- 924

Query: 1166 CDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEEN 1203
            C VH     G  R S     SL P    C      ++N
Sbjct: 925  CFVHPCTGVGECRSS-----SLQPVKTKCTSDSYYQDN 957



 Score =  164 bits (414), Expect = 1e-39
 Identities = 214/855 (25%), Positives = 305/855 (35%), Gaps = 198/855 (23%)

Query: 1604 EDIDECSTHSGICGPGTCYNTLGNYTCVCPAEY--------LQVNGGNNCMDMRKSVCFR 1655
            + I E ++HSG+  P   + TL   T V   EY             G N     +   F 
Sbjct: 149  DSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFG 208

Query: 1656 HY------NGTCQNELAFNVTRKMCC---CSYNIGQA-----------WNRP-CEAC-PT 1693
            HY      N TC          +  C   CS   G             W    C+ C P 
Sbjct: 209  HYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPH 268

Query: 1694 P------ISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ-IGSFRC 1746
            P       +  +Q LC     G L D       D++ CG        G C N     ++C
Sbjct: 269  PGCVHGICNEPWQCLCETNWGGQLCD------KDLNYCGTHQPCLNGGTCSNTGPDKYQC 322

Query: 1747 ECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC-VG 1805
             CP G++  +    CE + E      PC     C      + C+C+ G+    G  C   
Sbjct: 323  SCPEGYSGPN----CE-IAEHACLSDPCHNRGSCKETSLGFECECSPGWT---GPTCSTN 374

Query: 1806 RNECREIPNVCSHGD-CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNG-TCKN 1863
             ++C   PN CSHG  C D    + C+C   +     Q   +D +EC+ +PC N  +CKN
Sbjct: 375  IDDCS--PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQ---LDANECEAKPCVNAKSCKN 429

Query: 1864 IIGSY-------------------------------------NCLCFPGFVVTHNGDCV- 1885
            +I SY                                      C+C PG+   H   C  
Sbjct: 430  LIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDH---CER 486

Query: 1886 DFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNC-VDTNECLSLAGTCLPGT 1944
            D DEC +        GHC N    F CLC  GF     G  C +D + C      C  G 
Sbjct: 487  DIDECAS--NPCLNGGHCQNEINRFQCLCPTGF----SGNLCQLDIDYC--EPNPCQNGA 538

Query: 1945 -CQNLEGSFRCICPPGFQVQS-----DHCID-----IDECSE--------------EPNL 1979
             C N    + C CP  ++ ++     DHC       ID C+                 N+
Sbjct: 539  QCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNV 598

Query: 1980 C-LFGTC-TNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKT 2037
            C   G C + S G F C C  GF  +       D   + C      G C           
Sbjct: 599  CGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPC---RNGGTC----IDGVNSY 651

Query: 2038 RCCCSKRPGEGWG--------DPCELCPQEGSAAFQEL-----CPFGHGAVPGPDDSRED 2084
            +C CS    +GW         + C   P       ++L     C   +G       SR+ 
Sbjct: 652  KCICS----DGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRD- 706

Query: 2085 VNECAENPGVCTN-GVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPC-GQGTCT 2142
             ++C E    C N G C +   +F+C CP G+  + T  N      C + +PC   GTC 
Sbjct: 707  -SQCDE--ATCNNGGTCYDEGDAFKCMCPGGW--EGTTCNIARNSSC-LPNPCHNGGTCV 760

Query: 2143 NVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDG 2202
                 F C C +G+E  +    ++ ++CS +P   +  C + +  Y C C  G+     G
Sbjct: 761  VNGESFTCVCKEGWEGPI--CAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFA----G 814

Query: 2203 AMCR-DVDECADGQQDCHARGMECKNLIGTFACVCPPGM----------RPLPGSG---- 2247
              CR +++EC   Q    A G  C + I  + CVCPPG           RP    G    
Sbjct: 815  PDCRININEC---QSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIP 871

Query: 2248 EGCTDDNECHAQPDLCVNGRCVNT---AGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEV 2304
            +G   D++C+     C+NGR   +    G   C   +G    P+   C  I    CF   
Sbjct: 872  DGAKWDDDCNTCQ--CLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHP 929

Query: 2305 LQTMCRSLSSSSEAV 2319
               +    SSS + V
Sbjct: 930  CTGVGECRSSSLQPV 944



 Score =  144 bits (364), Expect = 9e-34
 Identities = 169/639 (26%), Positives = 236/639 (36%), Gaps = 198/639 (30%)

Query: 419 CLNG-RCLPT-PSSYRCECNVGYTQDVRGECIDVDE--CTSSPCHH-GDCVNIPGTYHCR 473
           CLNG  C  T P  Y+C C  GY+    G   ++ E  C S PCH+ G C      + C 
Sbjct: 306 CLNGGTCSNTGPDKYQCSCPEGYS----GPNCEIAEHACLSDPCHNRGSCKETSLGFECE 361

Query: 474 CYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDH 532
           C PG+   PT     ++D+C  +    H G C +    F+CVC   +     GK C +D 
Sbjct: 362 CSPGWTG-PT--CSTNIDDCSPNN-CSHGGTCQDLVNGFKCVCPPQWT----GKTCQLDA 413

Query: 533 NECATSTMCVNGV-CLNEDGSFSCLCKPGFL----------------------------- 562
           NEC     CVN   C N   S+ C C PG++                             
Sbjct: 414 NECEAKP-CVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYR 472

Query: 563 --LAPG--GHYC-MDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC---VD- 613
               PG  G +C  DIDEC +      GHC N    F+C C      G  G +C   +D 
Sbjct: 473 CICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLC----PTGFSGNLCQLDIDY 528

Query: 614 -----THVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQL----------- 657
                    + CY       C  P      + + C    DH    PC++           
Sbjct: 529 CEPNPCQNGAQCYNRASDYFCKCP---EDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASN 585

Query: 658 -------------------CPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCAN-GV 697
                              C ++   +F   C+ G   T    +IN+C  +P  C N G 
Sbjct: 586 DTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNP--CRNGGT 643

Query: 698 CENLRGSYRCVCNLGYEAGASGKDC-TDVDECA-------------LNSLLCD--NGW-- 739
           C +   SY+C+C+ G+E    G  C T++++C+             +N   CD  NGW  
Sbjct: 644 CIDGVNSYKCICSDGWE----GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKG 699

Query: 740 --------------------CQNSPGSYSCSCPPGFHFWQDT--EICKDVDECLSSPCVS 777
                               C +   ++ C CP G   W+ T   I ++   CL +PC +
Sbjct: 700 KTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGG---WEGTTCNIARN-SSCLPNPCHN 755

Query: 778 -GVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCA 836
            G C     S+TC C  G      G  C  +T          + C  +         C  
Sbjct: 756 GGTCVVNGESFTCVCKEGW----EGPICAQNT----------NDCSPH--------PCYN 793

Query: 837 TLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNECESFPGVCPNG-RCVNTAGSFRC 894
           +     G    RCE    CA GFA   G  C  ++NEC+S P  C  G  CV+    +RC
Sbjct: 794 SGTCVDGDNWYRCE----CAPGFA---GPDCRININECQSSP--CAFGATCVDEINGYRC 844

Query: 895 ECPEGLMLDASGRLCVDVRLEPCF---------LRWDED 924
            CP G     SG  C +V   PC           +WD+D
Sbjct: 845 VCPPG----HSGAKCQEVSGRPCITMGSVIPDGAKWDDD 879



 Score =  143 bits (360), Expect = 3e-33
 Identities = 178/736 (24%), Positives = 275/736 (37%), Gaps = 137/736 (18%)

Query: 51  PGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGE-------GFCSQPN---- 99
           PG + G  +C   +   C   W    G   C   +    CG        G CS       
Sbjct: 269 PGCVHG--ICNEPWQCLCETNW----GGQLCDKDL--NYCGTHQPCLNGGTCSNTGPDKY 320

Query: 100 LCTCADGTLAPSCGVSRGSGCSVSCMNGGTCR----GASCLCQKGYTGTVCGQPICD--- 152
            C+C +G   P+C ++  +  S  C N G+C+    G  C C  G+TG  C   I D   
Sbjct: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSP 380

Query: 153 RGCHNGGRC---IGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKAL 209
             C +GG C   +   +C C   + G  C+ D         V  + C++ +    C    
Sbjct: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD--C 438

Query: 210 CCATVGRAWGLPCELCPAQ---PHPCR------RGFIPNIHTG-ACQ-DVDECQAVPGLC 258
               +G+   +    C  Q      CR      R   P  + G  C+ D+DEC + P L 
Sbjct: 439 LPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCL- 497

Query: 259 QGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCC 318
            GG C N +  F C CP G   +      +      C +   G +C    + ++    C 
Sbjct: 498 NGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQN---GAQCYNRASDYF----CK 550

Query: 319 CDRGRCWAAGPVPELCPPRGSNEFQQLC-------AQRLPLLPGHPGLFPGLLGFGSNGM 371
           C           PE    +  +  +  C            +         G+    SN  
Sbjct: 551 C-----------PEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVC 599

Query: 372 GPPLGPARLNPHG---SDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLN-GRCLPT 427
           G         PHG   S + G  +        GT   ++ I+ C   +N C N G C+  
Sbjct: 600 G---------PHGKCKSQSGGKFTCDCNKGFTGT-YCHENINDCE--SNPCRNGGTCIDG 647

Query: 428 PSSYRCECNVGYTQDVRGEC-IDVDECTSSPCHH-GDCVNIPGTYHCRCYPGFQATPTRQ 485
            +SY+C C+ G+       C  ++++C+ +PCH+ G C ++   ++C C  G++      
Sbjct: 648 VNSYKCICSDGWE---GAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS 704

Query: 486 ACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVN- 543
                DE   + G    G C +   +F+C+C  G+E    G  C +  N       C N 
Sbjct: 705 RDSQCDEATCNNG----GTCYDEGDAFKCMCPGGWE----GTTCNIARNSSCLPNPCHNG 756

Query: 544 GVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVN-GHCTNTEGSFRCQCLGGL 602
           G C+    SF+C+CK G+     G  C       +P  C N G C + +  +RC+C  G 
Sbjct: 757 GTCVVNGESFTCVCKEGW----EGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGF 812

Query: 603 AVGTDGRVCVDTHVRSTC-YGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAK 661
           A G D R+ ++    S C +GA    +C     G      C C  P H  G  CQ    +
Sbjct: 813 A-GPDCRININECQSSPCAFGA----TCVDEING----YRCVCP-PGHS-GAKCQEVSGR 861

Query: 662 DSAEFQALCSSGLGITTDGR----DINECALDPEVCANG--VCENL-RGSYRCVCNLGYE 714
                   C +   +  DG     D N C      C NG   C  +  G   C+ + G+ 
Sbjct: 862 P-------CITMGSVIPDGAKWDDDCNTCQ-----CLNGRIACSKVWCGPRPCLLHKGHS 909

Query: 715 AGASGKDCTDV--DEC 728
              SG+ C  +  D+C
Sbjct: 910 ECPSGQSCIPILDDQC 925



 Score =  126 bits (317), Expect = 3e-28
 Identities = 192/803 (23%), Positives = 282/803 (35%), Gaps = 183/803 (22%)

Query: 91  GEGFCSQPNLCTCADGTLAPSCG--VSRGSGCSV---SCMNGGTCRGASCLCQKGYTGTV 145
           G   C Q    TC +G + P C   + R  GCS    SC   G CR     CQ G+ G  
Sbjct: 208 GHYACDQNGNKTCMEGWMGPECNRAICR-QGCSPKHGSCKLPGDCR-----CQYGWQGLY 261

Query: 146 C--------------------------GQPICDRG---------CHNGGRC--IGPNR-- 166
           C                          G  +CD+          C NGG C   GP++  
Sbjct: 262 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ 321

Query: 167 CACVYGFMGPQC---ERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCE 223
           C+C  G+ GP C   E    + PC  +     C+    G  C     C+           
Sbjct: 322 CSCPEGYSGPNCEIAEHACLSDPCHNR---GSCKETSLGFECE----CSPGWTGPTCSTN 374

Query: 224 LCPAQPHPCRRG------------FIPNIHTG-ACQ-DVDECQAVPGLCQGGSCVNMVGS 269
           +    P+ C  G              P   TG  CQ D +EC+A P      SC N++ S
Sbjct: 375 IDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP-CVNAKSCKNLIAS 433

Query: 270 FHCRCPVGH-------RLSDSSAACEDYRAGACFSVLFGGR--CAGDLAGHYTRR---QC 317
           ++C C  G         ++D    C++    +C  ++ G R  C    AG +  R   +C
Sbjct: 434 YYCDCLPGWMGQNCDININDCLGQCQN--DASCRDLVNGYRCICPPGYAGDHCERDIDEC 491

Query: 318 ----CCDRGRCW-AAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMG 372
               C + G C         LCP   S    QL        P   G              
Sbjct: 492 ASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKC 551

Query: 373 PPLGPARLNPHGSD-ARGIPSLGPGNSNIGTATLNQTIDICRHF-TNLC-LNGRC-LPTP 428
           P     +   H  D  R  P     +  +  A+ N T +  R+  +N+C  +G+C   + 
Sbjct: 552 PEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMAS-NDTPEGVRYISSNVCGPHGKCKSQSG 610

Query: 429 SSYRCECNVGYTQDVRGECIDVDECTSSPCHH-GDCVNIPGTYHCRCYPGFQATPTRQAC 487
             + C+CN G+T     E  ++++C S+PC + G C++   +Y C C  G++        
Sbjct: 611 GKFTCDCNKGFTGTYCHE--NINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE--- 665

Query: 488 VDVDECIVSGGLCHL-GRCVNTEGSFQCVCNAGFELSPDGKNCVDH-NECATSTMCVNGV 545
            ++++C  S   CH  G C +    F C C  G++    GK C    ++C  +T    G 
Sbjct: 666 TNINDC--SQNPCHNGGTCRDLVNDFYCDCKNGWK----GKTCHSRDSQCDEATCNNGGT 719

Query: 546 CLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVN-GHCTNTEGSFRCQCLGGLAV 604
           C +E  +F C+C  G+    G    +  +    P  C N G C     SF C C      
Sbjct: 720 CYDEGDAFKCMCPGGW---EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVC----KE 772

Query: 605 GTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEP-CQLCPAKDS 663
           G +G +C       + +     G+C            C CA    GF  P C++      
Sbjct: 773 GWEGPICAQNTNDCSPHPCYNSGTCV----DGDNWYRCECA---PGFAGPDCRI------ 819

Query: 664 AEFQALCSSGLGITTDGRDINECALDPEVCANG-VCENLRGSYRCVCNLGYEA------- 715
                             +INEC   P  CA G  C +    YRCVC  G+         
Sbjct: 820 ------------------NINECQSSP--CAFGATCVDEINGYRCVCPPGHSGAKCQEVS 859

Query: 716 -------------GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTE 762
                        GA   D  +  +C    + C   WC    G   C    G       +
Sbjct: 860 GRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWC----GPRPCLLHKGHSECPSGQ 915

Query: 763 ICKDV--DECLSSPCVS-GVCRN 782
            C  +  D+C   PC   G CR+
Sbjct: 916 SCIPILDDQCFVHPCTGVGECRS 938


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  215 bits (547), Expect = 6e-55
 Identities = 228/783 (29%), Positives = 305/783 (38%), Gaps = 157/783 (20%)

Query: 1032 CRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTD 1091
            CR   D  G  TC          C  G+     + K C +   C +   L  GG CT   
Sbjct: 211  CRPRNDFFGHYTCDQYGNK---ACMDGW-----MGKECKEA-VCKQGCNLLHGG-CTVPG 260

Query: 1092 GSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHA---GFQSTP 1148
               +C+C  G +    G  C   DEC    G C HG CV     +QC+C     G     
Sbjct: 261  ---ECRCSYGWQ----GRFC---DECVPYPG-CVHGSCVE---PWQCNCETNWGGLLCDK 306

Query: 1149 DRQGCVDINECRVQNGGCDVHCINTE-GSYRCSCGQGYSLMPDGRACADVDE-CEENPRV 1206
            D   C   + C   NGG    CIN E   YRC+C  GYS    GR C   +  C  NP  
Sbjct: 307  DLNYCGSHHPCT--NGGT---CINAEPDQYRCTCPDGYS----GRNCEKAEHACTSNP-C 356

Query: 1207 CDQGHCTNMPGGHRCLCYDGFMATPDMRTC-VDVDECDLNPHICLHGDCENTKGSFVCHC 1265
             + G C  +P G  C C  G+       TC +D+DEC  NP     G C +    F C C
Sbjct: 357  ANGGSCHEVPSGFECHCPSGWSGP----TCALDIDECASNP-CAAGGTCVDQVDGFECIC 411

Query: 1266 QLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH-DLDE 1324
               ++   GAT   D +ECE  G  C +  SC N+ G + C C+PGW   G  CH ++++
Sbjct: 412  PEQWV---GATCQLDANECE--GKPCLNAFSCKNLIGGYYCDCIPGW--KGINCHINVND 464

Query: 1325 CVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAENVDLCDNGQCLNAPG 1383
            C  Q   C   G C ++   Y+C C +GF G    CE +RDECA +      G C +   
Sbjct: 465  CRGQ---CQHGGTCKDLVNGYQCVCPRGFGGR--HCELERDECASS-PCHSGGLCEDLAD 518

Query: 1384 GYRCECEMGFDPTEDHRACQ-DVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGN 1442
            G+ C C  GF        C+ DVD C          C NL G + C C      D GG N
Sbjct: 519  GFHCHCPQGFSGP----LCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD----DFGGKN 570

Query: 1443 CTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA-GNCFLETHDRGD 1501
            C+   E      C  G C    G     C  D     +G G   T A G C         
Sbjct: 571  CSVPRE-----PCPGGACRVIDG-----CGSD-----AGPGMPGTAASGVCGPHGRCVSQ 615

Query: 1502 SGISCSAEIGVGVTRASCCCSLGRAWGNPCE---LCPMANTTEYRTLCPGG-EGFQPNRI 1557
             G + S     G T   C  ++    G PC     C +     +R  CP G EG      
Sbjct: 616  PGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC-IDEVDAFRCFCPSGWEG------ 668

Query: 1558 TVILEDIDECQELPGLCQG-GDCVNTFGSFQCECPPGYHLSEHTRICEDID-ECSTHSGI 1615
               L D +    LP  C   G C +    F C C  G+      + C   + +C  ++  
Sbjct: 669  --ELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDAYTCS 722

Query: 1616 CGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRH---YNGTCQNELAFNVTRK 1672
             G GTCY++   + C CP  +     G+ C   + S C  +     GTC           
Sbjct: 723  NG-GTCYDSGDTFRCACPPGW----KGSTCAVAKNSSCLPNPCVNGGTC----------- 766

Query: 1673 MCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAIC 1732
                   +G   +  C             +C +   G     +T      ++C  +P  C
Sbjct: 767  -------VGSGASFSC-------------ICRDGWEGRTCTHNT------NDCNPLP--C 798

Query: 1733 AN-GICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 1791
             N GIC++ +  FRCEC  GF      +   ++DEC S  SPC   A C++    YRC C
Sbjct: 799  YNGGICVDGVNWFRCECAPGFAGPDCRI---NIDECQS--SPCAYGATCVDEINGYRCSC 853

Query: 1792 TRG 1794
              G
Sbjct: 854  PPG 856



 Score =  209 bits (532), Expect = 3e-53
 Identities = 226/854 (26%), Positives = 337/854 (39%), Gaps = 154/854 (18%)

Query: 1817 SHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCK---NIIGSYNCLCF 1873
            SH   ++ E  +  L   G  A  +  + +  DE       N  C+   +  G Y C  +
Sbjct: 167  SHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQY 226

Query: 1874 PGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFH--------CLCQDGFELTADGK 1925
                   N  C+D       +G+ C+   C       H        C C  G++    G+
Sbjct: 227  G------NKACMD-----GWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQ----GR 271

Query: 1926 NCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ-VQSDHCIDIDECSEEPNLCLFGT 1984
             C   +EC+   G C+ G+C      ++C C   +  +  D   D++ C         GT
Sbjct: 272  FC---DECVPYPG-CVHGSCVE---PWQCNCETNWGGLLCDK--DLNYCGSHHPCTNGGT 322

Query: 1985 CTNS-PGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSK 2043
            C N+ P  ++C CP G+    +G  C                          K    C+ 
Sbjct: 323  CINAEPDQYRCTCPDGY----SGRNC-------------------------EKAEHACTS 353

Query: 2044 RPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNT 2103
             P    G  C   P    + F+  CP G     GP  +  D++ECA NP     G CV+ 
Sbjct: 354  NPCANGGS-CHEVP----SGFECHCPSGWS---GPTCAL-DIDECASNP-CAAGGTCVDQ 403

Query: 2104 DGSFRCECPFGYSLDFTGINC-VDTDECSVGHPCGQG-TCTNVIGGFECACADGFEPGLM 2161
               F C CP      + G  C +D +EC  G PC    +C N+IGG+ C C  G++    
Sbjct: 404  VDGFECICPE----QWVGATCQLDANECE-GKPCLNAFSCKNLIGGYYCDCIPGWKG--- 455

Query: 2162 MTCE-DIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR-DVDECADGQQDCH 2219
            + C  ++++C          C +    Y C CP G+     G  C  + DECA     CH
Sbjct: 456  INCHINVNDCR-GQCQHGGTCKDLVNGYQCVCPRGF----GGRHCELERDECASSP--CH 508

Query: 2220 ARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-RCVNTAGSFRCD 2278
            + G+ C++L   F C CP G      SG  C  D +   +P  C NG RC N  G + C 
Sbjct: 509  SGGL-CEDLADGFHCHCPQGF-----SGPLCEVDVDL-CEPSPCRNGARCYNLEGDYYCA 561

Query: 2279 CDEGFQPSPTLTECHDIRQGPCFAEVLQTM--CRSLSSSSEAVTRAECCCGGGRGWGPRC 2336
            C + F        C   R+ PC     + +  C S +      T A   CG      P  
Sbjct: 562  CPDDFGGK----NCSVPRE-PCPGGACRVIDGCGSDAGPGMPGTAASGVCG------PHG 610

Query: 2337 ELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG-ECINSLGSFRCHCQAGYT 2395
                 PG + +  +C  G   T    ++D+C  L   C +G  CI+ + +FRC C +G+ 
Sbjct: 611  RCVSQPGGN-FSCICDSGFTGTYCHENIDDC--LGQPCRNGGTCIDEVDAFRCFCPSGWE 667

Query: 2396 PDATATTCLDMDECSQVPKPCTFL--CKNTKGSFLCSCPRGYLLEEDGRTCKDLD-ECTS 2452
             +   T   + ++C  +P PC     C +    F C+C  G+     G+TC   + +C +
Sbjct: 668  GELCDT---NPNDC--LPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDA 718

Query: 2453 RQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCE 2512
               +    C ++   F C CPPG+     A   N  C   P PC   G C  +  SF C 
Sbjct: 719  YTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCL--PNPCVNGGTCVGSGASFSCI 776

Query: 2513 CHQGFTLVSSGHGCEDVNECDGPHRCQHG--CQNQLGGYRCSCPQGFTQHSQWAQC-VDE 2569
            C  G+   +  H   D N    P  C +G  C + +  +RC C  GF        C ++ 
Sbjct: 777  CRDGWEGRTCTHNTNDCN----PLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINI 828

Query: 2570 NECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEV----DECAGRRGPCSYSC 2625
            +EC  SP   G A+C + + G+RC CP G    +A   CQEV      C  R  P  +  
Sbjct: 829  DECQSSPCAYG-ATCVDEINGYRCSCPPG----RAGPRCQEVIGFGRSCWSRGTPFPHGS 883

Query: 2626 ANTPGGFLCGCPQG 2639
            +       C C  G
Sbjct: 884  SWVEDCNSCRCLDG 897



 Score =  185 bits (469), Expect = 6e-46
 Identities = 182/698 (26%), Positives = 256/698 (36%), Gaps = 150/698 (21%)

Query: 609  RVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHG-FGEPCQLCPAKDSAE-- 665
            + C+D  +   C  A+ K  C     G     EC C+    G F + C   P        
Sbjct: 229  KACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCV 288

Query: 666  --FQALCSSGLGITTDGRDINECALDPEVCANGVCENLR-GSYRCVCNLGYEAGASGKDC 722
              +Q  C +  G     +D+N C         G C N     YRC C  GY    SG++C
Sbjct: 289  EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNC 344

Query: 723  TDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSG---- 778
               +    ++   + G C   P  + C CP G   W       D+DEC S+PC +G    
Sbjct: 345  EKAEHACTSNPCANGGSCHEVPSGFECHCPSG---WSGPTCALDIDECASNPCAAGGTCV 401

Query: 779  -----------------------------------VCRNLAGSYTCKCGPG--------- 794
                                                C+NL G Y C C PG         
Sbjct: 402  DQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHIN 461

Query: 795  -----SRLDPSGTFCLDSTKG---TCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPC 846
                  +    GT C D   G    C        CE+       R EC +       SPC
Sbjct: 462  VNDCRGQCQHGGT-CKDLVNGYQCVCPRGFGGRHCELE------RDECAS-------SPC 507

Query: 847  ERCEIDPACARGF-----ARMTGVTCD-DVNECESFPGVCPNG-RCVNTAGSFRCECPEG 899
                +    A GF        +G  C+ DV+ CE  P  C NG RC N  G + C CP+ 
Sbjct: 508  HSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE--PSPCRNGARCYNLEGDYYCACPD- 564

Query: 900  LMLDASGRLCVDVRLEPC------FLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEA 953
               D  G+ C  V  EPC       +     + G  +PG     VC        G     
Sbjct: 565  ---DFGGKNC-SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVC--------GPHGRC 612

Query: 954  CPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTH-GTCRNTVGSFHCA 1012
               P    F+ +C  G         +G   ++++++C   P  C + GTC + V +F C 
Sbjct: 613  VSQPGG-NFSCICDSG--------FTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCF 661

Query: 1013 CAGGFALDAQERNCTDIDECRISPDLC-GQGTCVNTPGSFECECFPGYESGFMLMKNCMD 1071
            C  G+  +  + N  D       PD C  +G C +    F C C  G++      K C  
Sbjct: 662  CPSGWEGELCDTNPND-----CLPDPCHSRGRCYDLVNDFYCACDDGWKG-----KTCHS 711

Query: 1072 VDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPH-GQC 1129
              E   D   C  GGTC ++  +++C CPPG     KG+ C      S     C + G C
Sbjct: 712  -REFQCDAYTCSNGGTCYDSGDTFRCACPPGW----KGSTCAVAKNSSCLPNPCVNGGTC 766

Query: 1130 VNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMP 1189
            V    +F C C  G++         D N     NGG    C++    +RC C  G++  P
Sbjct: 767  VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI---CVDGVNWFRCECAPGFA-GP 822

Query: 1190 DGRACADVDECEENPRVCDQG-HCTNMPGGHRCLCYDG 1226
            D R   ++DEC+ +P  C  G  C +   G+RC C  G
Sbjct: 823  DCR--INIDECQSSP--CAYGATCVDEINGYRCSCPPG 856



 Score =  172 bits (436), Expect = 4e-42
 Identities = 193/741 (26%), Positives = 275/741 (37%), Gaps = 169/741 (22%)

Query: 1595 HLSEHTRI-CEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMD------ 1647
            HL    R+ C++    +T +  C P   +   G+YTC          G   CMD      
Sbjct: 189  HLELQIRVRCDENYYSATCNKFCRPRNDF--FGHYTC-------DQYGNKACMDGWMGKE 239

Query: 1648 MRKSVCFRHYN---GTCQNELAFNVTRKMCCCSYNIGQAWN-RPCEAC-PTP-------I 1695
             +++VC +  N   G C            C CSY     W  R C+ C P P       +
Sbjct: 240  CKEAVCKQGCNLLHGGC-------TVPGECRCSYG----WQGRFCDECVPYPGCVHGSCV 288

Query: 1696 SPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICIN-QIGSFRCECPAGFNY 1754
             P +Q  C     G L D       D++ CG        G CIN +   +RC CP G++ 
Sbjct: 289  EP-WQCNCETNWGGLLCD------KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSG 341

Query: 1755 NSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC-VGRNECREIP 1813
             +    CE  +   +  +PC     C  +P  + C C  G+    G  C +  +EC   P
Sbjct: 342  RN----CEKAEHACT-SNPCANGGSCHEVPSGFECHCPSGWS---GPTCALDIDECASNP 393

Query: 1814 NVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGN--------------- 1858
               + G C+D    + C+C   +  +  Q   +D +EC+ +PC N               
Sbjct: 394  -CAAGGTCVDQVDGFECICPEQWVGATCQ---LDANECEGKPCLNAFSCKNLIGGYYCDC 449

Query: 1859 -----------------------GTCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLV 1894
                                   GTCK+++  Y C+C  GF   H   C ++ DEC +  
Sbjct: 450  IPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRH---CELERDECAS-- 504

Query: 1895 GQVCRFGH-CLNTAGSFHCLCQDGFELTADGKNC-VDTNECLSLAGTCLPGT-CQNLEGS 1951
               C  G  C + A  FHC C  GF     G  C VD + C      C  G  C NLEG 
Sbjct: 505  -SPCHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLC--EPSPCRNGARCYNLEGD 557

Query: 1952 FRCICPPGF----------QVQSDHCIDIDECSEEPNLCLFGT-----------CTNSP- 1989
            + C CP  F                C  ID C  +    + GT           C + P 
Sbjct: 558  YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 617

Query: 1990 GSFQCLCPPGFV---LSDNGHRCFD---TRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSK 2043
            G+F C+C  GF      +N   C          C    +A +C  P  +        C  
Sbjct: 618  GNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGE----LCDT 673

Query: 2044 RPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTN-GVCVN 2102
             P +   DPC    +         C    G       SRE   +C  +   C+N G C +
Sbjct: 674  NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSRE--FQC--DAYTCSNGGTCYD 729

Query: 2103 TDGSFRCECPFGYSLDFTGINC-VDTDECSVGHPC-GQGTCTNVIGGFECACADGFEPGL 2160
            +  +FRC CP G+     G  C V  +   + +PC   GTC      F C C DG+E   
Sbjct: 730  SGDTFRCACPPGWK----GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEG-- 783

Query: 2161 MMTC-EDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR-DVDECADGQQDC 2218
              TC  + ++C+  P      C +    + C C  G+     G  CR ++DEC   Q   
Sbjct: 784  -RTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINIDEC---QSSP 835

Query: 2219 HARGMECKNLIGTFACVCPPG 2239
             A G  C + I  + C CPPG
Sbjct: 836  CAYGATCVDEINGYRCSCPPG 856



 Score =  167 bits (422), Expect = 2e-40
 Identities = 220/882 (24%), Positives = 308/882 (34%), Gaps = 198/882 (22%)

Query: 91  GEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSC--MNGGTCRGASCLCQKGYTGTVCGQ 148
           G   C Q     C DG +   C   + + C   C  ++GG      C C  G+ G  C +
Sbjct: 219 GHYTCDQYGNKACMDGWMGKEC---KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDE 275

Query: 149 PICDRGCHNGGRCIGPNRCACVYGFMGPQCERDY----------RTGPCFGQVGPE---G 195
            +   GC +G  C+ P +C C   + G  C++D             G C      +    
Sbjct: 276 CVPYPGCVHGS-CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCT 334

Query: 196 CQHQLTGLVCTKA-LCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTG-----ACQDVD 249
           C    +G  C KA   C +   A G  C   P+       GF  +  +G        D+D
Sbjct: 335 CPDGYSGRNCEKAEHACTSNPCANGGSCHEVPS-------GFECHCPSGWSGPTCALDID 387

Query: 250 ECQAVPGLCQGGSCVNMVGSFHCRCP---VGHRLSDSSAACEDYRAGACFSV--LFGGRC 304
           EC + P    GG+CV+ V  F C CP   VG      +  CE       FS   L GG  
Sbjct: 388 ECASNP-CAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYY 446

Query: 305 AGDLAG------HYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPG 358
              + G      H     C   RG+C   G   +L      N +Q +C +          
Sbjct: 447 CDCIPGWKGINCHINVNDC---RGQCQHGGTCKDLV-----NGYQCVCPR---------- 488

Query: 359 LFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNL 418
                 GFG               H    R   +  P +S                    
Sbjct: 489 ------GFGGR-------------HCELERDECASSPCHS-------------------- 509

Query: 419 CLNGRCLPTPSSYRCECNVGYTQDVRGEC-IDVDECTSSPCHHG-DCVNIPGTYHCRC-- 474
              G C      + C C  G++  +   C +DVD C  SPC +G  C N+ G Y+C C  
Sbjct: 510 --GGLCEDLADGFHCHCPQGFSGPL---CEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 564

Query: 475 -YPGFQATPTRQ-----ACVDVDEC----------IVSGGLC-HLGRCVNTE-GSFQCVC 516
            + G   +  R+     AC  +D C            + G+C   GRCV+   G+F C+C
Sbjct: 565 DFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 624

Query: 517 NAGFELSPDGKNCVDHNECATSTMCVN-GVCLNEDGSFSCLCKPGFLLAPGGHYC-MDID 574
           ++GF     G  C ++ +      C N G C++E  +F C C  G+     G  C  + +
Sbjct: 625 DSGF----TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGW----EGELCDTNPN 676

Query: 575 ECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFP 634
           +C        G C +    F C C      G  G+ C     +   Y     G+C     
Sbjct: 677 DCLPDPCHSRGRCYDLVNDFYCAC----DDGWKGKTCHSREFQCDAYTCSNGGTCYD--- 729

Query: 635 GTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCA 694
              +     CA P    G  C +  AK+S+     C +G                     
Sbjct: 730 ---SGDTFRCACPPGWKGSTCAV--AKNSSCLPNPCVNG--------------------- 763

Query: 695 NGVCENLRGSYRCVCNLGYEAGASGKDCT-DVDECALNSLLCDNGW-CQNSPGSYSCSCP 752
            G C     S+ C+C  G+E    G+ CT + ++C  N L C NG  C +    + C C 
Sbjct: 764 -GTCVGSGASFSCICRDGWE----GRTCTHNTNDC--NPLPCYNGGICVDGVNWFRCECA 816

Query: 753 PGFHFWQDTEICKDVDECLSSPCVSG-VCRNLAGSYTCKCGPGSRLDPSGTFCLD--STK 809
           PGF    D  I  ++DEC SSPC  G  C +    Y C C PG     +G  C +     
Sbjct: 817 PGF-AGPDCRI--NIDECQSSPCAYGATCVDEINGYRCSCPPGR----AGPRCQEVIGFG 869

Query: 810 GTCWLKIQESRCEVNLQGASLRSEC--CATLGAAWGSPCERCEIDPACARGFARMTGVTC 867
            +CW     SR      G+S   +C  C  L          C   P    G        C
Sbjct: 870 RSCW-----SRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQC 924

Query: 868 DDVNEC-ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRL 908
                C E  PG C    C         E P    L  SG L
Sbjct: 925 PLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHL 966



 Score =  151 bits (382), Expect = 8e-36
 Identities = 158/598 (26%), Positives = 227/598 (37%), Gaps = 138/598 (23%)

Query: 2087 ECAENPGVCTNGVCVNTDGSF---RCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTN 2143
            EC E   VC  G  +   G      C C +G+   F        DEC     C  G+C  
Sbjct: 239  ECKE--AVCKQGCNLLHGGCTVPGECRCSYGWQGRFC-------DECVPYPGCVHGSC-- 287

Query: 2144 VIGGFECACADGFEPGLMMTCEDIDEC-SLNPLLCAFRCHNTE-GSYLCTCPAGYTLRED 2201
             +  ++C C   +  G ++  +D++ C S +P      C N E   Y CTCP GY+    
Sbjct: 288  -VEPWQCNCETNW--GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS---- 340

Query: 2202 GAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCT-DDNECHAQP 2260
            G  C   +        C A G  C  +   F C CP G      SG  C  D +EC + P
Sbjct: 341  GRNCEKAEHACTSNP-C-ANGGSCHEVPSGFECHCPSGW-----SGPTCALDIDECASNP 393

Query: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT 2320
                 G CV+    F C C E +  +    + ++    PC        C++L        
Sbjct: 394  -CAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAF---SCKNLIGGYY--- 446

Query: 2321 RAECCCGGGRGW-GPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG-E 2378
                 C    GW G  C +                        +V++CR     C HG  
Sbjct: 447  -----CDCIPGWKGINCHI------------------------NVNDCR---GQCQHGGT 474

Query: 2379 CINSLGSFRCHCQAGYTPDATATTC-LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLL 2437
            C + +  ++C C  G+        C L+ DEC+  P     LC++    F C CP+G+  
Sbjct: 475  CKDLVNGYQCVCPRGFG----GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF-- 528

Query: 2438 EEDGRTCK-DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH----------QACFDN 2486
               G  C+ D+D C          C N  G + C CP  F   +           AC   
Sbjct: 529  --SGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVI 586

Query: 2487 DECSAQPGP----------CGAHGHCHNTPG-SFRCECHQGFTLVSSGHGC-EDVNECDG 2534
            D C +  GP          CG HG C + PG +F C C  GFT    G  C E++++C G
Sbjct: 587  DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT----GTYCHENIDDCLG 642

Query: 2535 PHRCQHG--CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSAS-CRNTLGGF 2591
               C++G  C +++  +RC CP G+       +  D N     P  C S   C + +  F
Sbjct: 643  -QPCRNGGTCIDEVDAFRCFCPSGWE-----GELCDTNPNDCLPDPCHSRGRCYDLVNDF 696

Query: 2592 RCVCPSGFDFDQALGGCQEVDECAGRRGPC-SYSCANTPGG--------FLCGCPQGY 2640
             C C  G+          +   C  R   C +Y+C+N  GG        F C CP G+
Sbjct: 697  YCACDDGW----------KGKTCHSREFQCDAYTCSN--GGTCYDSGDTFRCACPPGW 742



 Score =  149 bits (377), Expect = 3e-35
 Identities = 208/808 (25%), Positives = 299/808 (37%), Gaps = 171/808 (21%)

Query: 269 SFHCRCPVGHRLSDSSAAC-EDYRAGACFSVLFGGRCAGDLAGHYTRRQ----CCCDRGR 323
           S H    V H        C E+Y +  C       R   D  GHYT  Q     C D   
Sbjct: 180 SLHFSGHVAHLELQIRVRCDENYYSATCNKFC---RPRNDFFGHYTCDQYGNKACMDG-- 234

Query: 324 CWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPH 383
            W      E    +G N     C      +PG      G  G   +   P  G      H
Sbjct: 235 -WMGKECKEAVCKQGCNLLHGGCT-----VPGECRCSYGWQGRFCDECVPYPGCV----H 284

Query: 384 GSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPT-PSSYRCECNVGYTQD 442
           GS     P      +N G    ++ ++ C         G C+   P  YRC C  GY+  
Sbjct: 285 GSCVE--PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS-- 340

Query: 443 VRGECIDVDE--CTSSPC-HHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL 499
             G   +  E  CTS+PC + G C  +P  + C C  G+   PT    +D+DEC  S   
Sbjct: 341 --GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSG-PT--CALDIDEC-ASNPC 394

Query: 500 CHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVNGV-CLNEDGSFSCLC 557
              G CV+    F+C+C   +     G  C +D NEC     C+N   C N  G + C C
Sbjct: 395 AAGGTCVDQVDGFECICPEQWV----GATCQLDANEC-EGKPCLNAFSCKNLIGGYYCDC 449

Query: 558 KPGFLLAPGGHYCMDIDECQTPGICVN-GHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHV 616
            PG+    G +  +++++C+  G C + G C +    ++C C  G      GR C     
Sbjct: 450 IPGW---KGINCHINVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFG----GRHC----- 495

Query: 617 RSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAE-FQALCSSGLG 675
                  +E+  CA              ++P H  G    LC  +D A+ F   C  G  
Sbjct: 496 ------ELERDECA--------------SSPCHSGG----LC--EDLADGFHCHCPQGFS 529

Query: 676 ITTDGRDINECALDPEVCANGV-CENLRGSYRCVCNLGY--------EAGASGKDCTDVD 726
                 D++ C  +P  C NG  C NL G Y C C   +             G  C  +D
Sbjct: 530 GPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVID 587

Query: 727 EC-----------ALNSLLCDNGWCQNSP-GSYSCSCPPGFHFWQDTEICKDVDECLSSP 774
            C           A + +   +G C + P G++SC C  GF     T   +++D+CL  P
Sbjct: 588 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF---TGTYCHENIDDCLGQP 644

Query: 775 CVS-GVCRNLAGSYTCKC---GPGSRLDPSGTFCLDS---TKGTCWLKIQE--SRCEVNL 825
           C + G C +   ++ C C     G   D +   CL     ++G C+  + +    C+   
Sbjct: 645 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW 704

Query: 826 QGASLRS---EC----CATLGAAWGS-PCERCEIDPACARGFARMTGVTCDDVNECESFP 877
           +G +  S   +C    C+  G  + S    RC    AC  G+    G TC         P
Sbjct: 705 KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC----ACPPGW---KGSTCAVAKNSSCLP 757

Query: 878 GVCPN-GRCVNTAGSFRCECPEGLMLDASGRLCV----DVRLEPCF--------LRWDED 924
             C N G CV +  SF C C +G      GR C     D    PC+        + W   
Sbjct: 758 NPCVNGGTCVGSGASFSCICRDGW----EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813

Query: 925 ECGVTLPG---KYRMDVC---CCSIGA-----VWGVECEACPDPESLEFASLCPRGLGFA 973
           EC     G   +  +D C    C+ GA     + G  C +CP   +      C   +GF 
Sbjct: 814 ECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRC-SCPPGRA---GPRCQEVIGFG 869

Query: 974 SRDFLSGRPF------YKDVNECKVFPG 995
              +  G PF       +D N C+   G
Sbjct: 870 RSCWSRGTPFPHGSSWVEDCNSCRCLDG 897



 Score =  135 bits (339), Expect = 7e-31
 Identities = 138/482 (28%), Positives = 185/482 (38%), Gaps = 98/482 (20%)

Query: 2211 CADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGS--------GEGCTDDNECHAQPDL 2262
            C DG       G ECK  +    C    G   +PG         G  C   +EC   P  
Sbjct: 231  CMDGWM-----GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC---DECVPYPG- 281

Query: 2263 CVNGRCVNTAGSFRCDCDE---GFQPSPTLTECHD----IRQGPCF-AEVLQTMC----- 2309
            CV+G CV     ++C+C+    G      L  C         G C  AE  Q  C     
Sbjct: 282  CVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338

Query: 2310 ---RSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDE 2366
               R+   +  A T   C  GG       C   P    S +   CP G        D+DE
Sbjct: 339  YSGRNCEKAEHACTSNPCANGGS------CHEVP----SGFECHCPSGWSGPTCALDIDE 388

Query: 2367 CRMLAHLCAHG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKG 2425
            C   ++ CA G  C++ +  F C C   +     AT  LD +EC   P    F CKN  G
Sbjct: 389  CA--SNPCAAGGTCVDQVDGFECICPEQWVG---ATCQLDANECEGKPCLNAFSCKNLIG 443

Query: 2426 SFLCSCPRGYLLEEDGRTCK-DLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQA 2482
             + C C  G+     G  C  ++++C  +   CQ    C + V  + C CP GF   H  
Sbjct: 444  GYYCDCIPGW----KGINCHINVNDCRGQ---CQHGGTCKDLVNGYQCVCPRGFGGRHCE 496

Query: 2483 CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNECDGPHRCQHG 2541
              + DEC++ P  C + G C +    F C C QGF    SG  CE DV+ C+ P  C++G
Sbjct: 497  -LERDECASSP--CHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLCE-PSPCRNG 548

Query: 2542 --CQNQLGGYRCSCPQGF--------TQHSQWAQCVDENECALS-----PPTCGSASC-- 2584
              C N  G Y C+CP  F         +      C   + C        P T  S  C  
Sbjct: 549  ARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGP 608

Query: 2585 -----RNTLGGFRCVCPSGFDFDQALGGCQE-VDECAGRRGPCSYSCANTPGGFLCGCPQ 2638
                     G F C+C SGF        C E +D+C G+      +C +    F C CP 
Sbjct: 609  HGRCVSQPGGNFSCICDSGFTGTY----CHENIDDCLGQPCRNGGTCIDEVDAFRCFCPS 664

Query: 2639 GY 2640
            G+
Sbjct: 665  GW 666



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 63/207 (30%), Positives = 83/207 (40%), Gaps = 24/207 (11%)

Query: 2440 DGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAH 2499
            DG   K+  E   +Q  C  L         CRC  G+    + C   DEC   PG C  H
Sbjct: 233  DGWMGKECKEAVCKQ-GCNLLHGGCTVPGECRCSYGW--QGRFC---DECVPYPG-C-VH 284

Query: 2500 GHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG--CQN-QLGGYRCSCPQG 2556
            G C   P    CE + G  L       +D+N C   H C +G  C N +   YRC+CP G
Sbjct: 285  GSCVE-PWQCNCETNWGGLLCD-----KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338

Query: 2557 FTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAG 2616
            ++  +    C        S P     SC     GF C CPSG+          ++DECA 
Sbjct: 339  YSGRN----CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTC---ALDIDECAS 391

Query: 2617 RRGPCSYSCANTPGGFLCGCPQGYFRA 2643
                   +C +   GF C CP+ +  A
Sbjct: 392  NPCAAGGTCVDQVDGFECICPEQWVGA 418



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 63/234 (26%), Positives = 84/234 (35%), Gaps = 55/234 (23%)

Query: 64  FHAYCCPGWR-----TFPGRSQCVVPICRRACGEGFCSQ---PNLCTCADGTLAPSCGVS 115
           F  +C  GW      T P  + C+   C      G C        C C DG    +C   
Sbjct: 658 FRCFCPSGWEGELCDTNP--NDCLPDPCH---SRGRCYDLVNDFYCACDDGWKGKTCHSR 712

Query: 116 RGSGCSVSCMNGGTCRGAS----CLCQKGYTGTVCG----QPICDRGCHNGGRCIGPNR- 166
                + +C NGGTC  +     C C  G+ G+ C            C NGG C+G    
Sbjct: 713 EFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 772

Query: 167 --CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCEL 224
             C C  G+ G  C   + T  C     P  C +   G +C         G  W   CE 
Sbjct: 773 FSCICRDGWEGRTCT--HNTNDC----NPLPCYN---GGICVD-------GVNW-FRCEC 815

Query: 225 CPAQPHP-CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVG 277
            P    P CR             ++DECQ+ P    G +CV+ +  + C CP G
Sbjct: 816 APGFAGPDCRI------------NIDECQSSP-CAYGATCVDEINGYRCSCPPG 856



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 77/313 (24%), Positives = 108/313 (34%), Gaps = 96/313 (30%)

Query: 61  GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 120
           G  F   C PGW+                                     +C V++ S C
Sbjct: 731 GDTFRCACPPGWK-----------------------------------GSTCAVAKNSSC 755

Query: 121 SVS-CMNGGTCRGA----SCLCQKGYTGTVCGQPICDRG---CHNGGRCI-GPN--RCAC 169
             + C+NGGTC G+    SC+C+ G+ G  C     D     C+NGG C+ G N  RC C
Sbjct: 756 LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCEC 815

Query: 170 VYGFMGPQCE---RDYRTGPC-FGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELC 225
             GF GP C     + ++ PC +G      C  ++ G  C+        GRA G  C+  
Sbjct: 816 APGFAGPDCRINIDECQSSPCAYGAT----CVDEINGYRCS-----CPPGRA-GPRCQEV 865

Query: 226 PAQPHPCRRGFIPNIHTGA-CQDVDECQAVPG-------LCQGGSCV--NMVGSFHCRCP 275
                 C     P  H  +  +D + C+ + G        C    C+      +   +CP
Sbjct: 866 IGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP 925

Query: 276 VGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP 335
           +G R       C +   G C                   R  C   G C A  P    C 
Sbjct: 926 LGQR-------CLEKAPGQCL------------------RPPCEAWGECGAEEPPSTPCL 960

Query: 336 PRGSNEFQQLCAQ 348
           PR S      CA+
Sbjct: 961 PR-SGHLDNNCAR 972


>gi|10190748 CEGP1 protein [Homo sapiens]
          Length = 999

 Score =  209 bits (532), Expect = 3e-53
 Identities = 146/447 (32%), Positives = 192/447 (42%), Gaps = 60/447 (13%)

Query: 944  GAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLC-THGTC 1002
            GA W V       P  L  A   P G G A+          +DV+EC      C     C
Sbjct: 10   GAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGP-------QEDVDECAQGLDDCHADALC 62

Query: 1003 RNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESG 1062
            +NT  S+ C+C  G+    + R C DIDEC    +      C+N PG++ C CF     G
Sbjct: 63   QNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCF----DG 116

Query: 1063 FMLMK---NCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC----EDID 1115
            FML     NC+DVDEC  +   C+  TC N  GSY+C C  G  L+     C    E+  
Sbjct: 117  FMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGL 175

Query: 1116 ECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEG 1175
             C   D  C H       G+  C C  GF+   +++ C  I  C   NGGC   C +T  
Sbjct: 176  SCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTAD 233

Query: 1176 SYRCSCGQGYSLMPDGRACAD----------------------------VDECEENPRVC 1207
               CSC   Y +  DGR+C +                            ++ C  N   C
Sbjct: 234  GPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC 293

Query: 1208 DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQL 1267
            D+  C +   G  C C  GF    D +TC D+DEC      C H  C+N  GSF C C+ 
Sbjct: 294  DRT-CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKK 351

Query: 1268 GYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGF-ECHDLDECV 1326
            G+ +      C DVDEC +    CD   SC+N PG+F+C C  G+   GF  C D +EC 
Sbjct: 352  GFKLLTDEKSCQDVDECSL-DRTCDH--SCINHPGTFACACNRGYTLYGFTHCGDTNECS 408

Query: 1327 SQEHRCSPRGDCLNVPGSYRCTCRQGF 1353
                 C  +  C+N  GSY C C  G+
Sbjct: 409  INNGGC--QQVCVNTVGSYECQCHPGY 433



 Score =  201 bits (512), Expect = 6e-51
 Identities = 137/415 (33%), Positives = 193/415 (46%), Gaps = 36/415 (8%)

Query: 407 QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC---TSSPCHHGDC 463
           Q +D C H   LC N     TP+SY+C C  GY  + R +C D+DEC    +  C H DC
Sbjct: 51  QGLDDC-HADALCQN-----TPTSYKCSCKPGYQGEGR-QCEDIDECGNELNGGCVH-DC 102

Query: 464 VNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELS 523
           +NIPG Y C C+ GF        C+DVDEC+ + G C    CVN  GS++C C  GF LS
Sbjct: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ-HTCVNVMGSYECCCKEGFFLS 161

Query: 524 PDGKNCVDHNECATSTMCVNGVCLN-----EDGSFSCLCKPGFLLAPGGHYCMDIDECQT 578
            +   C+  +E   S M  +  C +       GS +C C+PGF LA     C  I  C  
Sbjct: 162 DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNH 219

Query: 579 PGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVT 638
                   C +T     C C     + TDGR C++     T     E  + +        
Sbjct: 220 GNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLERE--DTVLEVTESNTTSVVDGDKRV 277

Query: 639 KSECC---CANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEV 692
           K       CA  + G    C+      S      C  G  +  DG+   DI+EC      
Sbjct: 278 KRRLLMETCAVNNGGCDRTCK----DTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG 333

Query: 693 CANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCP 752
           C +  C+N+ GS+ C C  G++     K C DVDEC+L+   CD+  C N PG+++C+C 
Sbjct: 334 CDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRT-CDHS-CINHPGTFACACN 390

Query: 753 PGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLD 806
            G+  +  T  C D +EC +++     VC N  GSY C+C PG +L  +   C++
Sbjct: 391 RGYTLYGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVE 444



 Score =  193 bits (491), Expect = 2e-48
 Identities = 165/558 (29%), Positives = 217/558 (38%), Gaps = 94/558 (16%)

Query: 2165 EDIDECS--LNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222
            ED+DEC+  L+       C NT  SY C+C  GY  + +G  C D+DEC  G +      
Sbjct: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDEC--GNELNGGCV 99

Query: 2223 MECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEG 2282
             +C N+ G + C C  G   L   G  C D +EC      C +  CVN  GS+ C C EG
Sbjct: 100  HDCLNIPGNYRCTCFDGFM-LAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEG 157

Query: 2283 FQPSPTLTEC-HDIRQG-PCFAEV--LQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCEL 2338
            F  S     C H   +G  C  +      +C+     S A     C C  G         
Sbjct: 158  FFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVA-----CECRPGFELAKNQRD 212

Query: 2339 CPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDA 2398
            C L         C HG+G                 C H  C ++     C C   Y    
Sbjct: 213  CILT--------CNHGNGG----------------CQHS-CDDTADGPECSCHPQYKMHT 247

Query: 2399 TATTCLD----------------------------MDECSQVPKPCTFLCKNTKGSFLCS 2430
               +CL+                            M+ C+     C   CK+T     CS
Sbjct: 248  DGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCS 307

Query: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGF--TQHHQACFDNDE 2488
            CP G+ L+ DG+TCKD+DEC +R   C   C N VG+F C C  GF      ++C D DE
Sbjct: 308  CPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDE 367

Query: 2489 CSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQNQLG 2547
            CS           C N PG+F C C++G+TL    H C D NEC      CQ  C N +G
Sbjct: 368  CSLDR---TCDHSCINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQVCVNTVG 423

Query: 2548 GYRCSCPQGFTQHSQWAQCVDEN---ECALSPPTCGSASCRNTLGGFRCV--CPSGFDFD 2602
             Y C C  G+  H     CV+       ++SP    S  C  + GG  C   C SG    
Sbjct: 424  SYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRV--SLHCGKSGGGDGCFLRCHSGIHLS 481

Query: 2603 QALGGCQEVDECAGRRGPCSYSCANT-PGGFLCGCPQGY------FRAGQGHCVSG--LG 2653
              +   +         G CS   A   P G     P+ +      FR     C SG  + 
Sbjct: 482  SDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQVP 541

Query: 2654 FSPGPQDTPDKEELLSSE 2671
             +PG   TP KE  ++ E
Sbjct: 542  GAPGRPSTP-KEMFITVE 558



 Score =  192 bits (488), Expect = 4e-48
 Identities = 138/442 (31%), Positives = 186/442 (42%), Gaps = 31/442 (7%)

Query: 1280 DVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCL 1339
            DVDEC  G  +C + A C N P S+ C C PG+ G+G +C D+DEC   E       DCL
Sbjct: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC-GNELNGGCVHDCL 103

Query: 1340 NVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTE 1397
            N+PG+YRCTC  GF  A DG  C D DEC EN   C +  C+N  G Y C C+ GF  ++
Sbjct: 104  NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSD 162

Query: 1398 DHRACQDVDE----CAQGNLCAFGSCENLP-GMFRCICNGGYELDRGGGNCTDINECADP 1452
            +   C    E    C   +      C+  P G   C C  G+EL +   +C  I  C   
Sbjct: 163  NQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHG 220

Query: 1453 VNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGV 1512
                   C +T     CSC   ++++  G  C++ R       T     S +     +  
Sbjct: 221  NGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE-REDTVLEVTESNTTSVVDGDKRVKR 279

Query: 1513 GVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPG 1572
             +   +C  + G      C+      +T     CP G   Q +  T   +DIDECQ   G
Sbjct: 280  RLLMETCAVNNG-----GCDRTCKDTSTGVHCSCPVGFTLQLDGKT--CKDIDECQTRNG 332

Query: 1573 LCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVC 1632
             C    C N  GSF C C  G+ L    + C+D+DECS         +C N  G + C C
Sbjct: 333  GCD-HFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTC--DHSCINHPGTFACAC 389

Query: 1633 PAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWN-RPC--- 1688
               Y  + G  +C D  +       NG CQ      V    C C       WN + C   
Sbjct: 390  NRGY-TLYGFTHCGDTNECSI---NNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445

Query: 1689 -EACPTPISPDYQILCGNQAPG 1709
                PT +SP   + CG    G
Sbjct: 446  KGLLPTSVSPRVSLHCGKSGGG 467



 Score =  178 bits (452), Expect = 6e-44
 Identities = 124/408 (30%), Positives = 176/408 (43%), Gaps = 44/408 (10%)

Query: 449 DVDECTSS--PCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDEC--IVSGGLCHLG 503
           DVDEC      CH    C N P +Y C C PG+Q    +  C D+DEC   ++GG  H  
Sbjct: 45  DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQ--CEDIDECGNELNGGCVH-- 100

Query: 504 RCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLL 563
            C+N  G+++C C  GF L+ DG NC+D +EC  +       C+N  GS+ C CK GF L
Sbjct: 101 DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFL 160

Query: 564 APGGHYCMDIDE----CQTPGICVNGHCTNT-EGSFRCQCLGGLAVGTDGRVCVDTHVRS 618
           +   H C+   E    C       +  C     GS  C+C  G  +  + R C+      
Sbjct: 161 SDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCI-----L 215

Query: 619 TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITT 678
           TC      G C      T    EC C +P +      + C  ++    +   S+   +  
Sbjct: 216 TCNHG--NGGCQHSCDDTADGPECSC-HPQYKMHTDGRSCLEREDTVLEVTESNTTSV-V 271

Query: 679 DGRDINECALDPEVCA--NG----VCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNS 732
           DG    +  L  E CA  NG     C++      C C +G+     GK C D+DEC   +
Sbjct: 272 DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRN 331

Query: 733 LLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCG 792
             CD+ +C+N  GS+ C C  GF    D + C+DVDEC         C N  G++ C C 
Sbjct: 332 GGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACN 390

Query: 793 PGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840
            G  L    T C D+           + C +N  G   +  C  T+G+
Sbjct: 391 RGYTL-YGFTHCGDT-----------NECSINNGGC--QQVCVNTVGS 424



 Score =  177 bits (450), Expect = 1e-43
 Identities = 138/465 (29%), Positives = 184/465 (39%), Gaps = 114/465 (24%)

Query: 868  DDVNECESFPGVC-PNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC 926
            +DV+EC      C  +  C NT  S++C C  G      GR C D+           DEC
Sbjct: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDI-----------DEC 90

Query: 927  G-----------VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASR 975
            G           + +PG YR   C C  G +   +   C                     
Sbjct: 91   GNELNGGCVHDCLNIPGNYR---CTCFDGFMLAHDGHNC--------------------- 126

Query: 976  DFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDE---- 1031
                      DV+EC    G C H TC N +GS+ C C  GF L   +  C    E    
Sbjct: 127  ---------LDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLS 176

Query: 1032 CRISPDLCGQGTCVNTP-GSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGG----- 1085
            C      C    C   P GS  CEC PG+E    L KN  D   C    L C  G     
Sbjct: 177  CMNKDHGCSH-ICKEAPRGSVACECRPGFE----LAKNQRD---CI---LTCNHGNGGCQ 225

Query: 1086 -TCTNTDGSYKCQCPPGHELTAKGTAC---ED-------------------------IDE 1116
             +C +T    +C C P +++   G +C   ED                         ++ 
Sbjct: 226  HSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMET 285

Query: 1117 CSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGS 1176
            C++++G C    C +      CSC  GF    D + C DI+EC+ +NGGCD  C N  GS
Sbjct: 286  CAVNNGGCDR-TCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344

Query: 1177 YRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236
            + C C +G+ L+ D ++C DVDEC  + R CD   C N PG   C C  G+        C
Sbjct: 345  FDCGCKKGFKLLTDEKSCQDVDECSLD-RTCDHS-CINHPGTFACACNRGY-TLYGFTHC 401

Query: 1237 VDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDV 1281
             D +EC +N   C    C NT GS+ C C  GY +      C +V
Sbjct: 402  GDTNECSINNGGC-QQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445



 Score =  167 bits (422), Expect = 2e-40
 Identities = 134/453 (29%), Positives = 199/453 (43%), Gaps = 58/453 (12%)

Query: 1403 QDVDECAQG--NLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVN--CING 1458
            +DVDECAQG  +  A   C+N P  ++C C  GY+ +  G  C DI+EC + +N  C++ 
Sbjct: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE--GRQCEDIDECGNELNGGCVHD 101

Query: 1459 VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRAS 1518
             C+N PG+Y C+C   F L   G  C+D     C     + G    +C   +G       
Sbjct: 102  -CLNIPGNYRCTCFDGFMLAHDGHNCLDV--DECL---ENNGGCQHTCVNVMG----SYE 151

Query: 1519 CCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD 1578
            CCC  G    +    C   + +E    C   +    +           C+E P       
Sbjct: 152  CCCKEGFFLSDNQHTC--IHRSEEGLSCMNKDHGCSHI----------CKEAPR------ 193

Query: 1579 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ 1638
                 GS  CEC PG+ L+++ R C  I  C+  +G C   +C +T     C C  +Y  
Sbjct: 194  -----GSVACECRPGFELAKNQRDC--ILTCNHGNGGC-QHSCDDTADGPECSCHPQYKM 245

Query: 1639 VNGGNNCMDMRKSVC-FRHYNGTCQNELAFNVTRKMCC--CSYNIGQAWNRPCEACPTPI 1695
               G +C++   +V      N T   +    V R++    C+ N G   +R C+   T +
Sbjct: 246  HTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC-DRTCKDTSTGV 304

Query: 1696 SPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYN 1755
                 +       GF   +      DIDEC      C +  C N +GSF C C  GF   
Sbjct: 305  HCSCPV-------GFTLQLDGKTCKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKLL 356

Query: 1756 SILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNV 1815
            +   +C+DVDEC S +  C  +  CIN PG++ C C RGY L     C   NEC  I N 
Sbjct: 357  TDEKSCQDVDEC-SLDRTCDHS--CINHPGTFACACNRGYTLYGFTHCGDTNEC-SINNG 412

Query: 1816 CSHGDCMDTEGSYMCLCHRGFQASADQTLCMDI 1848
                 C++T GSY C CH G++   ++  C+++
Sbjct: 413  GCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445



 Score =  166 bits (421), Expect = 2e-40
 Identities = 140/475 (29%), Positives = 190/475 (40%), Gaps = 98/475 (20%)

Query: 1697 PDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAIC-ANGICINQIGSFRCECPAGFNYN 1755
            P   +L G   PG       G   D+DEC +    C A+ +C N   S++C C  G+   
Sbjct: 23   PPLLLLAGAVPPG--RGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGE 80

Query: 1756 SILLACEDVDECGSR-ESPCQQNADCINIPGSYRCKCTRGYKLS-PGGACVGRNECREIP 1813
                 CED+DECG+     C    DC+NIPG+YRC C  G+ L+  G  C+  +EC E  
Sbjct: 81   G--RQCEDIDECGNELNGGCVH--DCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENN 136

Query: 1814 NVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDE----CDRQPCG-NGTCKNI-IGS 1867
              C H  C++  GSY C C  GF  S +Q  C+   E    C  +  G +  CK    GS
Sbjct: 137  GGCQH-TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGS 195

Query: 1868 YNCLCFPGFVVTHN-GDCVDFDECTTLVGQVCRFGH------CLNTAGSFHCLCQDGFEL 1920
              C C PGF +  N  DC+            C  G+      C +TA    C C   +++
Sbjct: 196  VACECRPGFELAKNQRDCI----------LTCNHGNGGCQHSCDDTADGPECSCHPQYKM 245

Query: 1921 TADGKNCVDTNECL---------------------SLAGTCLPG------TCQNLEGSFR 1953
              DG++C++  + +                      L  TC         TC++      
Sbjct: 246  HTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVH 305

Query: 1954 CICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFD 2011
            C CP GF +Q D   C DIDEC      C    C N  GSF C C  GF L  +   C D
Sbjct: 306  CSCPVGFTLQLDGKTCKDIDECQTRNGGC-DHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364

Query: 2012 TRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFG 2071
                         +CS+ +  + +     C   PG                     C   
Sbjct: 365  -----------VDECSLDRTCDHS-----CINHPG------------------TFACACN 390

Query: 2072 HGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
             G          D NEC+ N G C   VCVNT GS+ C+C  GY L +   +CV+
Sbjct: 391  RGYTLYGFTHCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVE 444



 Score =  166 bits (421), Expect = 2e-40
 Identities = 129/449 (28%), Positives = 184/449 (40%), Gaps = 83/449 (18%)

Query: 854  ACARGFARMTGVTCDDVNEC-ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDV 912
            +C  G+ +  G  C+D++EC     G C +  C+N  G++RC C +G ML   G  C+DV
Sbjct: 72   SCKPGY-QGEGRQCEDIDECGNELNGGCVHD-CLNIPGNYRCTCFDGFMLAHDGHNCLDV 129

Query: 913  RLEPCFLRWDEDECG-----VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCP 967
              + C     E+  G     V + G Y    CCC  G         C             
Sbjct: 130  --DECL----ENNGGCQHTCVNVMGSYE---CCCKEGFFLSDNQHTC--------IHRSE 172

Query: 968  RGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCT 1027
             GL   ++D                    C+H       GS  C C  GF L   +R+C 
Sbjct: 173  EGLSCMNKDH------------------GCSHICKEAPRGSVACECRPGFELAKNQRDC- 213

Query: 1028 DIDECRISPDLCGQGTCVNTPGSFECECFPGYE--------------------------- 1060
             I  C      C Q +C +T    EC C P Y+                           
Sbjct: 214  -ILTCNHGNGGC-QHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271

Query: 1061 SGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLS 1120
             G   +K  + ++ CA +   C   TC +T     C CP G  L   G  C+DIDEC   
Sbjct: 272  DGDKRVKRRLLMETCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTR 330

Query: 1121 DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCS 1180
            +G C H  C N++G+F C C  GF+   D + C D++EC +    CD  CIN  G++ C+
Sbjct: 331  NGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR-TCDHSCINHPGTFACA 388

Query: 1181 CGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVD 1240
            C +GY+L      C D +EC  N   C Q  C N  G + C C+ G+    + + CV+V 
Sbjct: 389  CNRGYTLY-GFTHCGDTNECSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVK 446

Query: 1241 ---ECDLNPHICLH-GDCENTKGSFV-CH 1264
                  ++P + LH G      G F+ CH
Sbjct: 447  GLLPTSVSPRVSLHCGKSGGGDGCFLRCH 475



 Score =  164 bits (414), Expect = 1e-39
 Identities = 121/413 (29%), Positives = 169/413 (40%), Gaps = 56/413 (13%)

Query: 1929 DTNECLSLAGTC-LPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTN 1987
            D +EC      C     CQN   S++C C PG+Q +   C DIDEC  E N      C N
Sbjct: 45   DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLN 104

Query: 1988 SPGSFQCLCPPGFVLSDNGHRCFDTR---------QSFCFTRFEAGKCSVPKAFNTTKTR 2038
             PG+++C C  GF+L+ +GH C D           Q  C     + +C   + F  +  +
Sbjct: 105  IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQ 164

Query: 2039 CCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV---PG---PDDSREDVNECAENP 2092
              C  R  EG    C +    G +   +  P G  A    PG     + R+ +  C    
Sbjct: 165  HTCIHRSEEGLS--C-MNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGN 221

Query: 2093 GVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDE----------------------- 2129
            G C +  C +T     C C   Y +   G +C++ ++                       
Sbjct: 222  GGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRR 280

Query: 2130 -----CSVGHPCGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECSLNPLLCAFRCHN 2183
                 C+V +     TC +   G  C+C  GF   L   TC+DIDEC      C   C N
Sbjct: 281  LLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKN 340

Query: 2184 TEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPL 2243
              GS+ C C  G+ L  D   C+DVDEC+  +   H+    C N  GTFAC C  G   L
Sbjct: 341  IVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS----CINHPGTFACACNRGY-TL 395

Query: 2244 PGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIR 2296
             G    C D NEC      C    CVNT GS+ C C  G++      +C +++
Sbjct: 396  YGFTH-CGDTNECSINNGGC-QQVCVNTVGSYECQCHPGYKLHWNKKDCVEVK 446



 Score =  160 bits (406), Expect = 1e-38
 Identities = 125/432 (28%), Positives = 184/432 (42%), Gaps = 77/432 (17%)

Query: 1762 EDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNEC-REIPNVCSHGD 1820
            EDVDEC      C  +A C N P SY+C C  GY+   G  C   +EC  E+   C H D
Sbjct: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ-GEGRQCEDIDECGNELNGGCVH-D 101

Query: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVT 1879
            C++  G+Y C C  GF  + D   C+D+DEC     G   TC N++GSY C C  GF ++
Sbjct: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLS 161

Query: 1880 HN-GDCVD-FDECTTLVGQVCRFGHCLNTA--GSFHCLCQDGFELTADGKNCVDTNECLS 1935
             N   C+   +E  + + +     H    A  GS  C C+ GFEL  + ++C+ T  C  
Sbjct: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILT--CNH 219

Query: 1936 LAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCID------------------------ 1969
              G C   +C +      C C P +++ +D   C++                        
Sbjct: 220  GNGGC-QHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVK 278

Query: 1970 ----IDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGK 2025
                ++ C+     C   TC ++     C CP GF L  +G  C D  +  C TR   G 
Sbjct: 279  RRLLMETCAVNNGGC-DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDE--CQTR--NGG 333

Query: 2026 CSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDV 2085
            C            C C K                    F+ L           + S +DV
Sbjct: 334  CDHFCKNIVGSFDCGCKK-------------------GFKLLT---------DEKSCQDV 365

Query: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVI 2145
            +EC+ +   C +  C+N  G+F C C  GY+L +   +C DT+ECS+ +   Q  C N +
Sbjct: 366  DECSLD-RTCDHS-CINHPGTFACACNRGYTL-YGFTHCGDTNECSINNGGCQQVCVNTV 422

Query: 2146 GGFECACADGFE 2157
            G +EC C  G++
Sbjct: 423  GSYECQCHPGYK 434



 Score =  139 bits (349), Expect = 5e-32
 Identities = 115/442 (26%), Positives = 169/442 (38%), Gaps = 78/442 (17%)

Query: 1361 EDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG-NLCAFGS 1418
            ED DECA+ +D C  +  C N P  Y+C C+ G+    + R C+D+DEC    N      
Sbjct: 44   EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQG--EGRQCEDIDECGNELNGGCVHD 101

Query: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELN 1478
            C N+PG +RC C  G+ L   G NC D++EC +        C+N  GSY C C + F L+
Sbjct: 102  CLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLS 161

Query: 1479 PSGVGCV--DTRAGNCFLETH---------DRGDSGISCSAEIGVGVTRASC--CCSLGR 1525
             +   C+       +C  + H          RG     C     +   +  C   C+ G 
Sbjct: 162  DNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGN 221

Query: 1526 ----------AWGNPCELCPMANTTEYRTLCPGGEG-----FQPNRITVILED------- 1563
                      A G  C   P          C   E       + N  +V+  D       
Sbjct: 222  GGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281

Query: 1564 -IDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCY 1622
             ++ C    G C    C +T     C CP G+ L    + C+DIDEC T +G C    C 
Sbjct: 282  LMETCAVNNGGCD-RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGC-DHFCK 339

Query: 1623 NTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQ 1682
            N +G++ C C   +  +    +C D+ +    R    TC +    +     C C      
Sbjct: 340  NIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDR----TCDHSCINHPGTFACAC------ 389

Query: 1683 AWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIG 1742
              NR                 G    GF    H G   D +EC      C   +C+N +G
Sbjct: 390  --NR-----------------GYTLYGF---THCG---DTNECSINNGGCQQ-VCVNTVG 423

Query: 1743 SFRCECPAGFNYNSILLACEDV 1764
            S+ C+C  G+  +     C +V
Sbjct: 424  SYECQCHPGYKLHWNKKDCVEV 445



 Score =  130 bits (326), Expect = 2e-29
 Identities = 112/428 (26%), Positives = 171/428 (39%), Gaps = 78/428 (18%)

Query: 1540 TEYRTLC-PG--GEGFQPNRITVILEDIDEC-QELPGLCQGGDCVNTFGSFQCECPPGYH 1595
            T Y+  C PG  GEG Q        EDIDEC  EL G C   DC+N  G+++C C  G+ 
Sbjct: 67   TSYKCSCKPGYQGEGRQ-------CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFM 118

Query: 1596 LSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFR 1655
            L+     C D+DEC  ++G C   TC N +G+Y C C   +   +  + C+         
Sbjct: 119  LAHDGHNCLDVDECLENNGGC-QHTCVNVMGSYECCCKEGFFLSDNQHTCIH-------- 169

Query: 1656 HYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIH 1715
                  ++E   +   K   CS+   +A   P  +      P ++ L  NQ    LT   
Sbjct: 170  ------RSEEGLSCMNKDHGCSHICKEA---PRGSVACECRPGFE-LAKNQRDCILT--- 216

Query: 1716 TGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLAC---ED--------- 1763
                     C      C +  C +      C C   +  ++   +C   ED         
Sbjct: 217  ---------CNHGNGGCQHS-CDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESN 266

Query: 1764 ----------------VDECGSRESPCQQNADCINIPGSYRCKCTRGYKLS-PGGACVGR 1806
                            ++ C      C +   C +      C C  G+ L   G  C   
Sbjct: 267  TTSVVDGDKRVKRRLLMETCAVNNGGCDRT--CKDTSTGVHCSCPVGFTLQLDGKTCKDI 324

Query: 1807 NECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIG 1866
            +EC+     C H  C +  GS+ C C +GF+   D+  C D+DEC      + +C N  G
Sbjct: 325  DECQTRNGGCDHF-CKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPG 383

Query: 1867 SYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN 1926
            ++ C C  G+ +     C D +EC+   G   +   C+NT GS+ C C  G++L  + K+
Sbjct: 384  TFACACNRGYTLYGFTHCGDTNECSINNGGCQQV--CVNTVGSYECQCHPGYKLHWNKKD 441

Query: 1927 CVDTNECL 1934
            CV+    L
Sbjct: 442  CVEVKGLL 449



 Score =  117 bits (294), Expect = 1e-25
 Identities = 112/436 (25%), Positives = 156/436 (35%), Gaps = 119/436 (27%)

Query: 407 QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDEC--TSSPCHHGDC 463
           + ID C +  N      CL  P +YRC C  G+     G  C+DVDEC   +  C H  C
Sbjct: 85  EDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH-TC 143

Query: 464 VNIPGTYHCRCYPGFQATPTRQACVDVDE------------------------------- 492
           VN+ G+Y C C  GF  +  +  C+   E                               
Sbjct: 144 VNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPG 203

Query: 493 ---------CIVS-----GGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNE---- 534
                    CI++     GG  H   C +T    +C C+  +++  DG++C++  +    
Sbjct: 204 FELAKNQRDCILTCNHGNGGCQH--SCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLE 261

Query: 535 ------------------------CATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYC 570
                                   CA +    +  C +      C C  GF L   G  C
Sbjct: 262 VTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321

Query: 571 MDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCA 630
            DIDECQT     +  C N  GSF C C  G  + TD + C D          +++ S  
Sbjct: 322 KDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD----------VDECSLD 371

Query: 631 RPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGL---GITTDGRDINECA 687
           R      T    C  +P                  F   C+ G    G T  G D NEC+
Sbjct: 372 R------TCDHSCINHP----------------GTFACACNRGYTLYGFTHCG-DTNECS 408

Query: 688 LDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCD-NGWCQNSPGS 746
           ++   C   VC N  GSY C C+ GY+   + KDC +V      S+    +  C  S G 
Sbjct: 409 INNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGG 467

Query: 747 YSC--SCPPGFHFWQD 760
             C   C  G H   D
Sbjct: 468 DGCFLRCHSGIHLSSD 483



 Score =  111 bits (278), Expect = 9e-24
 Identities = 67/214 (31%), Positives = 104/214 (48%), Gaps = 16/214 (7%)

Query: 424 CLPTPSSYRCECNVGYTQDVRGE-CIDVDECTS--SPCHHGDCVNIPGTYHCRCYPGFQA 480
           C  T +   C C VG+T  + G+ C D+DEC +    C H  C NI G++ C C  GF+ 
Sbjct: 297 CKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF-CKNIVGSFDCGCKKGFKL 355

Query: 481 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM 540
               ++C DVDEC +     H   C+N  G+F C CN G+ L     +C D NEC+ +  
Sbjct: 356 LTDEKSCQDVDECSLDRTCDH--SCINHPGTFACACNRGYTLY-GFTHCGDTNECSINNG 412

Query: 541 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGIC--VNGHCTNTEGSFRC-- 596
               VC+N  GS+ C C PG+ L      C+++       +   V+ HC  + G   C  
Sbjct: 413 GCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFL 472

Query: 597 QCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCA 630
           +C  G+ + +D      T +R++    + +G C+
Sbjct: 473 RCHSGIHLSSD-----VTTIRTSVTFKLNEGKCS 501



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 65/258 (25%), Positives = 91/258 (35%), Gaps = 44/258 (17%)

Query: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGA-SCLCQKGYTGTVCGQ 148
           C EGF    N  TC   +      +++  GCS  C      RG+ +C C+ G+      Q
Sbjct: 154 CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAP--RGSVACECRPGFE-LAKNQ 210

Query: 149 PICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQV-----GPEGCQHQLTGL 203
             C   C++G    G  + +C     GP+C        C  Q      G    + + T L
Sbjct: 211 RDCILTCNHGN---GGCQHSCDDTADGPECS-------CHPQYKMHTDGRSCLEREDTVL 260

Query: 204 VCTKALCCATVGR----AWGLPCELCPAQPHPCRR---------------GFIPNIHTGA 244
             T++   + V         L  E C      C R               GF   +    
Sbjct: 261 EVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKT 320

Query: 245 CQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRC 304
           C+D+DECQ   G C    C N+VGSF C C  G +L     +C+D              C
Sbjct: 321 CKDIDECQTRNGGCDH-FCKNIVGSFDCGCKKGFKLLTDEKSCQDVD-----ECSLDRTC 374

Query: 305 AGDLAGHYTRRQCCCDRG 322
                 H     C C+RG
Sbjct: 375 DHSCINHPGTFACACNRG 392



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 53/197 (26%), Positives = 72/197 (36%), Gaps = 45/197 (22%)

Query: 108 LAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPI------------CDRGC 155
           L  +C V+ G GC  +C +  T  G  C C  G+T  + G+              CD  C
Sbjct: 282 LMETCAVNNG-GCDRTCKDTST--GVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFC 338

Query: 156 HNGGRCIGPNRCACVYGFMGPQCERDYR-TGPCFGQVGPEGCQHQLTGLVCTKALCCATV 214
            N    +G   C C  GF     E+  +    C        C H       T A  CA  
Sbjct: 339 KN---IVGSFDCGCKKGFKLLTDEKSCQDVDECSLD---RTCDHSCINHPGTFA--CA-- 388

Query: 215 GRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRC 274
                            C RG+     T  C D +EC    G CQ   CVN VGS+ C+C
Sbjct: 389 -----------------CNRGYTLYGFTH-CGDTNECSINNGGCQQ-VCVNTVGSYECQC 429

Query: 275 PVGHRLSDSSAACEDYR 291
             G++L  +   C + +
Sbjct: 430 HPGYKLHWNKKDCVEVK 446



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 24/56 (42%), Positives = 30/56 (53%), Gaps = 1/56 (1%)

Query: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287
           C  GF+       C DVDEC    G CQ  +CVN++GS+ C C  G  LSD+   C
Sbjct: 113 CFDGFMLAHDGHNCLDVDECLENNGGCQH-TCVNVMGSYECCCKEGFFLSDNQHTC 167



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 39/142 (27%), Positives = 48/142 (33%), Gaps = 27/142 (19%)

Query: 1348 TCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCE------------CEMGFDP 1395
            +CR G   DG     R+ C     LC NG   N  G   CE                ++ 
Sbjct: 640  SCRAGTYYDGA----RERCI----LCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNM 691

Query: 1396 TEDHRACQDVDECAQG----NLCAFGSCENLPGMFRCI-CNGGYELDRGGGNCTDINECA 1450
            +E    CQ  +  A G     LCA G+ +   G   C  C GG      G   T   +C 
Sbjct: 692  SECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQG--ATSFQDCE 749

Query: 1451 DPVNCINGVCINTPGSYLCSCP 1472
              V C  G   NT       CP
Sbjct: 750  TRVQCSPGHFYNTTTHRCIRCP 771



 Score = 36.6 bits (83), Expect = 0.36
 Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 6/79 (7%)

Query: 245 CQDVDEC-QAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303
           C+D+DEC   + G C    C+N+ G++ C C  G  L+     C D     C      G 
Sbjct: 84  CEDIDECGNELNGGCVH-DCLNIPGNYRCTCFDGFMLAHDGHNCLD--VDECLE--NNGG 138

Query: 304 CAGDLAGHYTRRQCCCDRG 322
           C           +CCC  G
Sbjct: 139 CQHTCVNVMGSYECCCKEG 157



 Score = 35.4 bits (80), Expect = 0.80
 Identities = 47/183 (25%), Positives = 62/183 (33%), Gaps = 25/183 (13%)

Query: 1731 ICANGICINQIGSFRCE-CPAGFNYNSILLA-CEDVDECGSRESPCQQNADCINIPGSYR 1788
            +C NG   N+ G   CE CP   N  ++      ++ ECG    P + +AD     G   
Sbjct: 656  LCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSAD-----GFAP 710

Query: 1789 CKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCL-CHRGFQASADQTLCMD 1847
            C+        P     GR  C      C  G     +G+     C    Q S        
Sbjct: 711  CQLCALGTFQPEA---GRTSCFP----CGGGLATKHQGATSFQDCETRVQCSPGHFYNTT 763

Query: 1848 IDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTA 1907
               C R  C  GT +   G  NC+  PG   T      DFD  T +    C+   C    
Sbjct: 764  THRCIR--CPVGTYQPEFGKNNCVSCPGNTTT------DFDGSTNIT--QCKNRRCGGEL 813

Query: 1908 GSF 1910
            G F
Sbjct: 814  GDF 816



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 42/178 (23%), Positives = 61/178 (34%), Gaps = 33/178 (18%)

Query: 1080 LLCRGGTCTNTDGSYKCQ-CP-PGHELTAKGTACEDIDECS--------LSDGLCPHGQC 1129
            +LC  GT  N +G   C+ CP PG+    K     ++ EC          +DG  P   C
Sbjct: 655  ILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLC 714

Query: 1130 VNVIGAFQ-----CSCH-AGFQSTPDRQGCVDINECRVQNGGCDVHCINTE--------- 1174
               +G FQ      SC   G       QG     +C  +      H  NT          
Sbjct: 715  --ALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPV 772

Query: 1175 GSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPD 1232
            G+Y+   G+   +   G    D D    N   C    C    G      + G++ +P+
Sbjct: 773  GTYQPEFGKNNCVSCPGNTTTDFDG-STNITQCKNRRCGGELGD-----FTGYIESPN 824



 Score = 33.9 bits (76), Expect = 2.3
 Identities = 47/205 (22%), Positives = 64/205 (31%), Gaps = 45/205 (21%)

Query: 120 CSVSCMNGGTCRGASCLCQKGYTGT--------VCGQPICDRGCHNGGRCIGPNRCACVY 171
           C    +   T     C C+ GY G          CG  +     H+     G  RC C  
Sbjct: 56  CHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFD 115

Query: 172 GFM----GPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCC-----------ATVGR 216
           GFM    G  C        C    G  GCQH    ++ +   CC             + R
Sbjct: 116 GFMLAHDGHNC---LDVDECLENNG--GCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHR 170

Query: 217 A-WGLPC--------ELCPAQPH-----PCRRGFIPNIHTGACQDVDECQAVPGLCQGGS 262
           +  GL C         +C   P       CR GF    +   C  +  C    G CQ  S
Sbjct: 171 SEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQ-HS 227

Query: 263 CVNMVGSFHCRCPVGHRLSDSSAAC 287
           C +      C C   +++     +C
Sbjct: 228 CDDTADGPECSCHPQYKMHTDGRSC 252


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.501 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 148,188,210
Number of Sequences: 37866
Number of extensions: 8834037
Number of successful extensions: 65272
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 200
Number of HSP's successfully gapped in prelim test: 316
Number of HSP's that attempted gapping in prelim test: 15754
Number of HSP's gapped (non-prelim): 12038
length of query: 2809
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2689
effective length of database: 13,703,598
effective search space: 36848975022
effective search space used: 36848975022
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.