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Search of human proteins with 55749531
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]
(895 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55749531 splicing factor 3B subunit 2 [Homo sapiens] 1822 0.0
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 71 5e-12
gi|210032580 SET domain containing 1B [Homo sapiens] 70 7e-12
gi|48255900 SWI/SNF-related matrix-associated actin-dependent re... 67 7e-11
gi|48255898 SWI/SNF-related matrix-associated actin-dependent re... 67 7e-11
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 67 1e-10
gi|110349719 titin isoform N2-A [Homo sapiens] 65 2e-10
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 65 3e-10
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 65 4e-10
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 65 4e-10
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 64 6e-10
gi|11386183 WAS protein family, member 2 [Homo sapiens] 64 8e-10
gi|209180481 Cas-Br-M (murine) ecotropic retroviral transforming... 63 1e-09
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] 63 1e-09
gi|153792074 proline rich 12 [Homo sapiens] 62 2e-09
gi|55741677 SET domain containing 1A [Homo sapiens] 62 3e-09
gi|40807447 papillary renal cell carcinoma translocation-associa... 62 3e-09
gi|40807450 papillary renal cell carcinoma translocation-associa... 62 3e-09
gi|157168329 formin 1 [Homo sapiens] 61 4e-09
gi|110431370 espin [Homo sapiens] 61 4e-09
gi|104526627 triadin [Homo sapiens] 61 5e-09
gi|47132519 Ras association and pleckstrin homology domains 1 is... 60 9e-09
gi|149158690 HLA-B associated transcript-2 [Homo sapiens] 60 1e-08
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 59 2e-08
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 59 2e-08
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 59 2e-08
gi|72534686 Huntingtin interacting protein C isoform 1 [Homo sap... 59 2e-08
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 59 2e-08
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 59 2e-08
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 58 3e-08
>gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]
Length = 895
Score = 1822 bits (4719), Expect = 0.0
Identities = 895/895 (100%), Positives = 895/895 (100%)
Query: 1 MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ 60
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
Sbjct: 1 MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ 60
Query: 61 TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP 120
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
Sbjct: 61 TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP 120
Query: 121 MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ 180
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
Sbjct: 121 MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ 180
Query: 181 QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG 240
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
Sbjct: 181 QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG 240
Query: 241 APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA 300
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
Sbjct: 241 APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA 300
Query: 301 RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS 360
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
Sbjct: 301 RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS 360
Query: 361 DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK 420
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
Sbjct: 361 DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK 420
Query: 421 KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV 480
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
Sbjct: 421 KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV 480
Query: 481 TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL 540
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
Sbjct: 481 TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL 540
Query: 541 QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR 600
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
Sbjct: 541 QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR 600
Query: 601 LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES 660
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
Sbjct: 601 LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES 660
Query: 661 CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE 720
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
Sbjct: 661 CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE 720
Query: 721 EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET 780
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
Sbjct: 721 EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET 780
Query: 781 PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM 840
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
Sbjct: 781 PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM 840
Query: 841 TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF 895
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Sbjct: 841 TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF 895
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 70.9 bits (172), Expect = 5e-12
Identities = 96/423 (22%), Positives = 156/423 (36%), Gaps = 70/423 (16%)
Query: 81 PPMSAQLPGIPMP---PPPLGLPPLQPPP-PPPPPPPGLGLGFPMAHP-------PNLGP 129
PP+ P P P PPP P + PP PP P P +G P A P P+ GP
Sbjct: 636 PPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVG-SMPSAGPMPSAGPMPSAGP 694
Query: 130 PPPLRVGEPV---------------------------ALSEEERLKLAQQQAALLMQQEE 162
P R G P A S E+ + + +E
Sbjct: 695 VPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDE 754
Query: 163 RAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGT---PVPRPPQDMGQIGVRTPL 219
+ H E+ + LE + + + P+P PP P
Sbjct: 755 TFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPT 814
Query: 220 GPRVAAPVGPVGPTPTVLPMG-APVPRPRGPPPPPGDENREMDDPSVGPK------IPQA 272
GP A+P P P LP P+P P PPPPP + P + P+ P A
Sbjct: 815 GPPTASPPVPAKEEPEELPAAPGPLPPPP-PPPPPVPGPVTLPPPQLVPEGTPGGGGPPA 873
Query: 273 LEK---ILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRN 329
LE+ ++ + S +EE ++EEEE E E EE+ ++E++ +
Sbjct: 874 LEEDLTVININSSDEEEEEEEEEEEEEE------------EEEEEEEDFEEEEEDEEEYF 921
Query: 330 RKKKKKPQRVRGVSSESSGD-REKDSTRSRGSDSPAADVE-IEYVTEEPEIYE--PNFIF 385
+++++ + E G+ E++ + +VE +E+ T E+ E P
Sbjct: 922 EEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPT 981
Query: 386 FKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDD-SSDDEQEKKP 444
+ V+ E E EP L ++E +++G + + + S E E++
Sbjct: 982 LPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREG 1041
Query: 445 EAP 447
E+P
Sbjct: 1042 ESP 1044
Score = 55.5 bits (132), Expect = 2e-07
Identities = 69/301 (22%), Positives = 106/301 (35%), Gaps = 67/301 (22%)
Query: 78 AAPPPMSAQLPGIPMPPPPLG-----LPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPP 132
A PPP++ P PP P LP P PPPPPPP G PP L P
Sbjct: 806 ATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGT 865
Query: 133 LRVGEPVALSE----------EERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQK 182
G P AL E +E + +++ ++EE + + E E E+++
Sbjct: 866 PGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEE 925
Query: 183 RAAVLLEQERQQEIAKMGTPVPRPPQ------------DMGQIGVRTPLGPRVAAPVGPV 230
E+E ++E ++ + + G G G + P
Sbjct: 926 EEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPA 985
Query: 231 GPTPTVLPMGAPVPRP----------------RGPP----------PPPGDENREMDDPS 264
P P P P P P RG P G+ RE + P+
Sbjct: 986 LPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPA 1045
Query: 265 VGPKIPQALEK-----ILQLKESRQEEMNSQQ------EEEEMETDARSSLGQSASETEE 313
GP + +E+ L+E ++ + Q EEEMET+ + ++ E E+
Sbjct: 1046 AGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEA---EALQEKEQ 1102
Query: 314 D 314
D
Sbjct: 1103 D 1103
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/125 (31%), Positives = 55/125 (44%), Gaps = 13/125 (10%)
Query: 620 PVGPNAHKVP------PPWLIAMQRYGPPPSYPNLKIPG-LNSPIPESCSFGYHAGGWGK 672
P GP P P L A PPP P +PG + P P+ G GG G
Sbjct: 813 PTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGG-GP 871
Query: 673 PPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKP 732
P ++E V N+++ + + EEEE + E E D E EE+EEE +E++
Sbjct: 872 PALEEDLT-----VININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEE 926
Query: 733 DETGF 737
+E F
Sbjct: 927 EEEEF 931
Score = 38.5 bits (88), Expect = 0.028
Identities = 39/143 (27%), Positives = 50/143 (34%), Gaps = 27/143 (18%)
Query: 94 PPPLGLPPLQPPPPPPP-----PPPGLGLGFPMAHP-----------PNLGPPPPLRVGE 137
PPP LPP PPP PP P P GL + P P L P GE
Sbjct: 977 PPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGE 1036
Query: 138 -------PVALSEEERLKLAQQQAALLMQQEERA----KQQGDHSLKEHELLEQQKRAAV 186
P A + L + A + +EE K Q E +E + A
Sbjct: 1037 VEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEA 1096
Query: 187 LLEQERQQEIAKMGTPVPRPPQD 209
L E+E+ A + + PP D
Sbjct: 1097 LQEKEQDDTAAMLADFIDCPPDD 1119
Score = 33.9 bits (76), Expect = 0.69
Identities = 23/54 (42%), Positives = 25/54 (46%), Gaps = 11/54 (20%)
Query: 221 PRVAAPVGPVGPTPTVLPMGAPVPRPRGPPP-------PPGDENREMDDPSVGP 267
PRV P+ P+GPT P APVP P P P PPG PS GP
Sbjct: 633 PRVP-PLQPMGPT---CPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGP 682
Score = 30.4 bits (67), Expect = 7.7
Identities = 27/94 (28%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 167 QGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMG----TPVPRPPQDMGQIGVRTPLGPR 222
Q + SL+ + L R + MG TP P PP + P
Sbjct: 609 QREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPS--------PF 660
Query: 223 VAAPVGPVGPTPTV--LPMGAPVPRPRGPPPPPG 254
A P P GP P+V +P P+P GP P G
Sbjct: 661 RAPPFHPPGPMPSVGSMPSAGPMP-SAGPMPSAG 693
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 70.5 bits (171), Expect = 7e-12
Identities = 49/143 (34%), Positives = 67/143 (46%), Gaps = 27/143 (18%)
Query: 7 EPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLN 66
E + +L L P PPP G L ++ AE+ + G+R E++ + +G +
Sbjct: 582 EDEELDLGLGPRPPP-EPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDME 640
Query: 67 -----------------RPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPP 109
+P++ A P + A P +P+PPPP G PPL PPPPPP
Sbjct: 641 ISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLA--PTLPLPPPP-GFPPLPPPPPPP 697
Query: 110 PPPPGLGLGFPMAHPPNLGPPPP 132
PP P GFPM PP L PPPP
Sbjct: 698 PPQP----GFPM--PPPLPPPPP 714
Score = 59.3 bits (142), Expect = 2e-08
Identities = 94/416 (22%), Positives = 142/416 (34%), Gaps = 85/416 (20%)
Query: 80 PPPMSAQLPGIPMPPPPLGLPPLQPPPPPPP-------PPPGLGLGFPMAHPPNLGPPPP 132
PPP PG PMPPP LPP PPPPPPP PPP L + PP L P PP
Sbjct: 693 PPPPPPPQPGFPMPPP---LPP--PPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPP 747
Query: 133 LRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQER 192
G + + L Q + M + + + +L +
Sbjct: 748 FPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQ---------------------VLSRLM 786
Query: 193 QQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPP 252
+ A P G++ P P P P+P+ PP
Sbjct: 787 TGQGACPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLSNSGPGRGQHWPPLPKFDPSVPP 846
Query: 253 PGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEE-----------EEMETDAR 301
PG R+ +DP L + +LK + ++N + E ++ E A+
Sbjct: 847 PGYMPRQ-EDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAK 905
Query: 302 SSLGQSASETEEDTVSVSKKEK------------------------NRKRRNRKKKKKPQ 337
+SL S +D K++ + R K +
Sbjct: 906 ASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVK 965
Query: 338 RVRGVSSESSGDR----------EKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFK 387
R + SSGD+ E+D R D AD E +P+
Sbjct: 966 RKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVG------V 1019
Query: 388 RIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKK 443
R A L D E++++ ++ E++ ++ EEE +D DDD SDD E +
Sbjct: 1020 RRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESE 1075
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/173 (25%), Positives = 65/173 (37%), Gaps = 16/173 (9%)
Query: 88 PGIPMPPPP------LGLPPLQPPP-PPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVA 140
PG P PP GL + P P P L LG PP GPP P + ++
Sbjct: 552 PGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGL---LS 608
Query: 141 LSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMG 200
+ E L L + + +E + G+ + E+ + + +A + + + +
Sbjct: 609 QTAEVALDLVGDRTPTSEKMDEGQQSSGE----DMEISDDEMPSAPITSADCPKPMVV-- 662
Query: 201 TPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPP 253
TP + PL P P P P P G P+P P PPPPP
Sbjct: 663 TPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPP 715
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/65 (40%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 89 GIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLK 148
GIP PPPPL P PPPPPP P L P+ PP R + V EE ++
Sbjct: 1535 GIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVT---EEYME 1591
Query: 149 LAQQQ 153
LA+ +
Sbjct: 1592 LAKSR 1596
Score = 40.8 bits (94), Expect = 0.006
Identities = 58/247 (23%), Positives = 86/247 (34%), Gaps = 36/247 (14%)
Query: 84 SAQLPGIPMPPPPLGLPPL---QPPPPPPPPPPGLGLGFPMAHPPNLG--PPPPLRVGEP 138
S + P PPP PL +P PP PPPP + P G P P G P
Sbjct: 425 SGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTN-SMELGGRPTFGWSPEPCDSPGTP 483
Query: 139 VALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAK 198
S E+ D + E L EQ+ + L E + E+
Sbjct: 484 TLESSP--------------AGPEKPHDSLDSRI-EMLLKEQRTKLLFLREPDSDTELQM 528
Query: 199 MGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPT-PTVLPMGAPVPRPRGPPPPPGDEN 257
G+P+ Q+ P G + G GPT P+ P + P P DE+
Sbjct: 529 EGSPI---SSSSSQLSPLAPFGTN--SQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDED 583
Query: 258 REMD-------DPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASE 310
E+D P GP P L + Q E + + + E + + S G+
Sbjct: 584 EELDLGLGPRPPPEPGPPDPAGL--LSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEI 641
Query: 311 TEEDTVS 317
++++ S
Sbjct: 642 SDDEMPS 648
Score = 39.7 bits (91), Expect = 0.013
Identities = 32/118 (27%), Positives = 48/118 (40%), Gaps = 7/118 (5%)
Query: 158 MQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRT 217
++ E A ++ L E L + A E + +++ G + P ++ R
Sbjct: 1193 IETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARP 1252
Query: 218 PLGPRVAAP----VGPVGPTPTVLPMGAPVPRPR---GPPPPPGDENREMDDPSVGPK 268
PL P A V P P LP+ P+P PR P PPP E + PSV P+
Sbjct: 1253 PLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPE 1310
Score = 36.6 bits (83), Expect = 0.11
Identities = 33/159 (20%), Positives = 65/159 (40%), Gaps = 25/159 (15%)
Query: 274 EKILQLKESRQEEMNSQ-QEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKK 332
E + + +ES +EE ++ +EEEE + D S + +EDT EK+ + ++
Sbjct: 1039 ESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEE 1098
Query: 333 KKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEA 392
+ ++ SS E S SP++ + E V E
Sbjct: 1099 TVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREE--------------- 1143
Query: 393 FKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDS 431
E+E+E E++ E+ A+ + FE++ +++
Sbjct: 1144 ---------EEEEEEEEMVAEESMASAGPEDFEQDGEEA 1173
Score = 35.4 bits (80), Expect = 0.24
Identities = 26/69 (37%), Positives = 31/69 (44%), Gaps = 10/69 (14%)
Query: 71 RGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPP-PPPPPPPPGLGLGFPMAHPPNLGP 129
R + D P LP +P+ PP LPP +PP PP PPP P +HP P
Sbjct: 1258 RAPEHDLEVEPEPPMMLP-LPLQPP---LPPPRPPRPPSPPPEPET---TDASHPS--VP 1308
Query: 130 PPPLRVGEP 138
P PL P
Sbjct: 1309 PEPLAEDHP 1317
Score = 34.3 bits (77), Expect = 0.53
Identities = 50/184 (27%), Positives = 76/184 (41%), Gaps = 27/184 (14%)
Query: 595 KEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPP--PWLIAMQR--YGPPPSYPNLKI 650
KE T+L + D EL++ G P+ ++ ++ P P+ Q GP P
Sbjct: 508 KEQRTKLLFLREPDSDTELQME-GSPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSS 566
Query: 651 PGLN----SPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEID-- 704
GL +P+P+S G G P E G P + A ++T E +D
Sbjct: 567 TGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGPP--------DPAGLLSQTAEVALDLV 618
Query: 705 --RTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSG---LITPGGFSSVPAGME 759
RTP E ++SS E+ E SD++ P IT AD ++TPG + +
Sbjct: 619 GDRTPTSEKMDEGQQSS-GEDMEISDDEMPSAP--ITSADCPKPMVVTPGAAAVAAPSVL 675
Query: 760 TPEL 763
P L
Sbjct: 676 APTL 679
Score = 32.7 bits (73), Expect = 1.5
Identities = 43/179 (24%), Positives = 62/179 (34%), Gaps = 15/179 (8%)
Query: 699 EEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGM 758
E+E+ + E +EE+ EEEEEE+ D+D D+ D
Sbjct: 1035 EDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDS 1094
Query: 759 ETPELIELRKKKIE-----EAMDGSETPQLFTVLP---EKRTATVGGAMMGSTHIYDMST 810
+ E + + K E E+ + SE P E V +M
Sbjct: 1095 DEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVA 1154
Query: 811 VMSRKGPAP---ELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAE 866
S P E G E ALAP +D + M EE V + V E+ M+ E
Sbjct: 1155 EESMASAGPEDFEQDGEEAALAPGAPAVDSLGM----EEEVDIETEAVAPEERPSMLDE 1209
Score = 32.7 bits (73), Expect = 1.5
Identities = 30/96 (31%), Positives = 38/96 (39%), Gaps = 13/96 (13%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKL-AEIGAPIQGNREELVERLQSYTRQTGIV 64
P+PP PPPPPP +EL + +E P R+E+ E + G
Sbjct: 1545 PQPPP-----PPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPW 1599
Query: 65 LNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLP 100
P R ED PP S +L PP PL P
Sbjct: 1600 RRPPKKRHED---LVPPAGSPEL----SPPQPLFRP 1628
Score = 32.3 bits (72), Expect = 2.0
Identities = 41/180 (22%), Positives = 70/180 (38%), Gaps = 16/180 (8%)
Query: 671 GKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDED 730
G +ET + T+++E +E E + E +E + EEEEEE +E+
Sbjct: 1092 GDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEE 1151
Query: 731 KPDETG--------FITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQ 782
E F + + PG + GME IE EE + P
Sbjct: 1152 MVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPP 1211
Query: 783 LFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPE-----ELELDP 837
L + E + G + + + ++S + PA E++ L+PE +LE++P
Sbjct: 1212 LPVGVEEPADSREPPEEPGLSQ--EGAMLLSPEPPAKEVE-ARPPLSPERAPEHDLEVEP 1268
Score = 32.3 bits (72), Expect = 2.0
Identities = 35/139 (25%), Positives = 50/139 (35%), Gaps = 23/139 (16%)
Query: 120 PMAHPPNLGPPP-PLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELL 178
P P L PP P+ V EP E Q+ A+L+ E AK+ ++ L
Sbjct: 1200 PEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKE-----VEARPPL 1254
Query: 179 EQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLP 238
++ LE E P PP + PL P + P P P+P P
Sbjct: 1255 SPERAPEHDLEVE------------PEPPMMLP-----LPLQPPLPPPRPPRPPSPPPEP 1297
Query: 239 MGAPVPRPRGPPPPPGDEN 257
P PP P +++
Sbjct: 1298 ETTDASHPSVPPEPLAEDH 1316
Score = 31.6 bits (70), Expect = 3.4
Identities = 15/38 (39%), Positives = 22/38 (57%)
Query: 693 EFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDED 730
E + EE+E + + +EE +EEEEEEE D+D
Sbjct: 1028 ELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDD 1065
Score = 31.2 bits (69), Expect = 4.5
Identities = 91/388 (23%), Positives = 124/388 (31%), Gaps = 109/388 (28%)
Query: 45 GNREELVERLQS-YTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGI-------PMPPPP 96
G R+E L S +TG+ L P+ P P+ LP + P P PP
Sbjct: 1410 GRRDERSGPLASPVLLETGLPLPLPL----------PLPLPLALPAVLRAQARAPTPLPP 1459
Query: 97 LGLPPLQPPPPPPPPPPGLGLGFPMAHPPNL--GPPPPLRVGEPVALSEEERLKLAQQQA 154
L PL PPP PG P PP++ P +R AL E L Q Q
Sbjct: 1460 LLPAPLASCPPPMKRKPGR----PRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQT 1515
Query: 155 ALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIG 214
+ + R L + G P P PP
Sbjct: 1516 PVFPSTHD-------------------PRTVTL-------DFRNAGIPAPPPP------- 1542
Query: 215 VRTPLGPRVAAPVGPVGPTPTVL-------PMGAPVPRPRGPPP---------------- 251
P P P PV PT P A P PRG
Sbjct: 1543 --LPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWR 1600
Query: 252 -PPGDENREMDDPSVGPKI--PQALEKILQLKESRQEEM-------NSQQEEEEME---- 297
PP + ++ P+ P++ PQ L + S EEM N +EE++
Sbjct: 1601 RPPKKRHEDLVPPAGSPELSPPQPLFR----PRSEFEEMTILYDIWNGGIDEEDIRFLCV 1656
Query: 298 TDARSSLGQSASETEEDTVSV--------SKKEKNRKRRNRKKKKKPQRVRGVSSESSGD 349
T R + + DT+ V S K+K R R+ R G + D
Sbjct: 1657 TYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKRDDGIREHVTGCARSEGFYTIDKKD 1716
Query: 350 REKDSTRSRGS-DSPAADVEIEYVTEEP 376
+ + SR S D P AD + + +P
Sbjct: 1717 KLRYLNSSRASTDEPPADTQGMSIPAQP 1744
Score = 30.8 bits (68), Expect = 5.9
Identities = 15/34 (44%), Positives = 20/34 (58%)
Query: 700 EEEIDRTPWGELEPSDEESSEEEEEEESDEDKPD 733
EE+ + E E ++EE EEEEEE D+D D
Sbjct: 1034 EEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDD 1067
>gi|48255900 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a2 isoform a [Homo sapiens]
Length = 1590
Score = 67.0 bits (162), Expect = 7e-11
Identities = 108/428 (25%), Positives = 159/428 (37%), Gaps = 79/428 (18%)
Query: 80 PP--PMSAQLPGIPMP-PPPLGLP-----PLQ-----PPPPPPPPPPGLGLGFPMA-HPP 125
PP PM G P P PLG P P+ PP PP P L G P A P
Sbjct: 108 PPQSPMDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQP 167
Query: 126 NLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQ--QGDHSLKEHELLEQQKR 183
N GP P PV L + LA + A E + QG +L L+QQ++
Sbjct: 168 NRGPSP----FSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPG---LQQQQQ 220
Query: 184 AAVLLEQERQQEIAKMGTPVPRPPQDMGQ-------IGVRTPLGPRVAAPVGP--VGP-T 233
+Q++QQ+ + P +PPQ Q + P GP GP GP T
Sbjct: 221 QQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGP------GPELSGPST 274
Query: 234 PTVLPMGAPVPRPRGPPP----PPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNS 289
P LP+ AP RP PP PP + PSV P +LQL++ +
Sbjct: 275 PQKLPVPAPGGRPSPAPPAAAQPPA---AAVPGPSVPQPAPGQPSPVLQLQQKQSRISPI 331
Query: 290 QQEE--------EEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRG 341
Q+ + +E E ++ + E E S+ + + K + R
Sbjct: 332 QKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQ 391
Query: 342 VSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKK 401
+ E +D+T +S A E + E KL K
Sbjct: 392 LRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTE-------------KLEKQQKI 438
Query: 402 EKE-KEPEKLDKLENSAAPKKKGFEEEHKDSDDD-----------SSDDEQEKKPEAPKL 449
E+E K +K + NS K F+E H+ ++ E+E+K E ++
Sbjct: 439 EQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERI 498
Query: 450 SKKKLRRM 457
K+++RR+
Sbjct: 499 EKERMRRL 506
Score = 39.3 bits (90), Expect = 0.017
Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 8/94 (8%)
Query: 271 QALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNR 330
Q++ K + K +++EE + EEE E D +S SE + V + +K+ K R++
Sbjct: 1496 QSVFKSARQKIAKEEESEDESNEEEEEEDEE----ESESEAKSVKVKIKLNKKDDKGRDK 1551
Query: 331 -KKKKKPQR--VRGVSSESSGDREKDS-TRSRGS 360
K KK+P R + V S+ D E+D +S GS
Sbjct: 1552 GKGKKRPNRGKAKPVVSDFDSDEEQDEREQSEGS 1585
Score = 34.7 bits (78), Expect = 0.41
Identities = 93/487 (19%), Positives = 175/487 (35%), Gaps = 100/487 (20%)
Query: 30 QELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPG 89
Q+ Q + + P +++ L +Y R +G P L G + P P P
Sbjct: 232 QQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSG---PGPELSGPSTPQKLPVPAPGGRPS 288
Query: 90 IPMP----PPPLGLP-PLQPPPPPPPPPPGLGLG------FPMAHPPNLGP--------- 129
P PP +P P P P P P P L L P+ P L P
Sbjct: 289 PAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREY 348
Query: 130 --------------------PPPLRVGEPVALSEEERLKLAQQ---------------QA 154
PP LR V L L +Q +
Sbjct: 349 RLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLET 408
Query: 155 ALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIG 214
AL + +R+K+Q + E LE+Q++ + E++R+Q+ + + + +D +
Sbjct: 409 ALNSKAYKRSKRQTLREARMTEKLEKQQK--IEQERKRRQKHQEYLNSILQHAKDFKEYH 466
Query: 215 VRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALE 274
VA + + + V A R + ++ R + + +
Sbjct: 467 ------RSVAGKIQKL--SKAVATWHANTEREQKKETERIEKERMR---RLMAEDEEGYR 515
Query: 275 KILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKK 334
K++ K+ R+ QQ +E + ++L E ++ ++ K +K+R R+KKK
Sbjct: 516 KLIDQKKDRRLAYLLQQTDEYV-----ANLTNLVWEHKQ-----AQAAKEKKKRRRRKKK 565
Query: 335 KPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFK 394
+ G S D E S+ SD P V++ + ++ P ++ +
Sbjct: 566 AEENAEGGESALGPDGEPIDESSQMSDLP---VKVTHTETGKVLFGPEAPKASQLDAWLE 622
Query: 395 LTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKK----PEAPKLS 450
+ + + E+ D + E +D +++SS E E+K P + ++S
Sbjct: 623 MNPGYEVAPRSDSEESDS------------DYEEEDEEEESSRQETEEKILLDPNSEEVS 670
Query: 451 KKKLRRM 457
+K +++
Sbjct: 671 EKDAKQI 677
Score = 32.0 bits (71), Expect = 2.6
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 677 ETGKPLYGDVFGTNAAEFQTKTEEEE-IDRTPWGELEPSDEESSEEEEEEESDEDKPDET 735
ETGK L+G A++ E + P + E SD + EE+EEEES + +E
Sbjct: 601 ETGKVLFGPE-APKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEK 659
Query: 736 GFITP 740
+ P
Sbjct: 660 ILLDP 664
Score = 31.6 bits (70), Expect = 3.4
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 33/208 (15%)
Query: 247 RGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQ 306
RG PP E + P + ++ ++ ++ K+ E + E+E + S G+
Sbjct: 1368 RGRPPA---EKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGN---SSGR 1421
Query: 307 SASETEEDTVSVSKKEKNRK--RRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPA 364
SE S + + + R+ KK +R+R S GD EKD +
Sbjct: 1422 QLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQ-- 1479
Query: 365 ADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGF 424
+ E +IYE + I + +F++ + + KE+E E E
Sbjct: 1480 -----TFNLEGSQIYEDS-IVLQSVFKSAR--QKIAKEEESEDES--------------- 1516
Query: 425 EEEHKDSDDDSSDDEQEKKPEAPKLSKK 452
EE ++ D++ S+ E + KL+KK
Sbjct: 1517 NEEEEEEDEEESESEAKSVKVKIKLNKK 1544
>gi|48255898 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a2 isoform b [Homo sapiens]
Length = 1572
Score = 67.0 bits (162), Expect = 7e-11
Identities = 108/428 (25%), Positives = 159/428 (37%), Gaps = 79/428 (18%)
Query: 80 PP--PMSAQLPGIPMP-PPPLGLP-----PLQ-----PPPPPPPPPPGLGLGFPMA-HPP 125
PP PM G P P PLG P P+ PP PP P L G P A P
Sbjct: 108 PPQSPMDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQP 167
Query: 126 NLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQ--QGDHSLKEHELLEQQKR 183
N GP P PV L + LA + A E + QG +L L+QQ++
Sbjct: 168 NRGPSP----FSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPG---LQQQQQ 220
Query: 184 AAVLLEQERQQEIAKMGTPVPRPPQDMGQ-------IGVRTPLGPRVAAPVGP--VGP-T 233
+Q++QQ+ + P +PPQ Q + P GP GP GP T
Sbjct: 221 QQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGP------GPELSGPST 274
Query: 234 PTVLPMGAPVPRPRGPPP----PPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNS 289
P LP+ AP RP PP PP + PSV P +LQL++ +
Sbjct: 275 PQKLPVPAPGGRPSPAPPAAAQPPA---AAVPGPSVPQPAPGQPSPVLQLQQKQSRISPI 331
Query: 290 QQEE--------EEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRG 341
Q+ + +E E ++ + E E S+ + + K + R
Sbjct: 332 QKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQ 391
Query: 342 VSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKK 401
+ E +D+T +S A E + E KL K
Sbjct: 392 LRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTE-------------KLEKQQKI 438
Query: 402 EKE-KEPEKLDKLENSAAPKKKGFEEEHKDSDDD-----------SSDDEQEKKPEAPKL 449
E+E K +K + NS K F+E H+ ++ E+E+K E ++
Sbjct: 439 EQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERI 498
Query: 450 SKKKLRRM 457
K+++RR+
Sbjct: 499 EKERMRRL 506
Score = 39.3 bits (90), Expect = 0.017
Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 8/94 (8%)
Query: 271 QALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNR 330
Q++ K + K +++EE + EEE E D +S SE + V + +K+ K R++
Sbjct: 1478 QSVFKSARQKIAKEEESEDESNEEEEEEDEE----ESESEAKSVKVKIKLNKKDDKGRDK 1533
Query: 331 -KKKKKPQR--VRGVSSESSGDREKDS-TRSRGS 360
K KK+P R + V S+ D E+D +S GS
Sbjct: 1534 GKGKKRPNRGKAKPVVSDFDSDEEQDEREQSEGS 1567
Score = 34.7 bits (78), Expect = 0.41
Identities = 93/487 (19%), Positives = 175/487 (35%), Gaps = 100/487 (20%)
Query: 30 QELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPG 89
Q+ Q + + P +++ L +Y R +G P L G + P P P
Sbjct: 232 QQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSG---PGPELSGPSTPQKLPVPAPGGRPS 288
Query: 90 IPMP----PPPLGLP-PLQPPPPPPPPPPGLGLG------FPMAHPPNLGP--------- 129
P PP +P P P P P P P L L P+ P L P
Sbjct: 289 PAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREY 348
Query: 130 --------------------PPPLRVGEPVALSEEERLKLAQQ---------------QA 154
PP LR V L L +Q +
Sbjct: 349 RLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLET 408
Query: 155 ALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIG 214
AL + +R+K+Q + E LE+Q++ + E++R+Q+ + + + +D +
Sbjct: 409 ALNSKAYKRSKRQTLREARMTEKLEKQQK--IEQERKRRQKHQEYLNSILQHAKDFKEYH 466
Query: 215 VRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALE 274
VA + + + V A R + ++ R + + +
Sbjct: 467 ------RSVAGKIQKL--SKAVATWHANTEREQKKETERIEKERMR---RLMAEDEEGYR 515
Query: 275 KILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKK 334
K++ K+ R+ QQ +E + ++L E ++ ++ K +K+R R+KKK
Sbjct: 516 KLIDQKKDRRLAYLLQQTDEYV-----ANLTNLVWEHKQ-----AQAAKEKKKRRRRKKK 565
Query: 335 KPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFK 394
+ G S D E S+ SD P V++ + ++ P ++ +
Sbjct: 566 AEENAEGGESALGPDGEPIDESSQMSDLP---VKVTHTETGKVLFGPEAPKASQLDAWLE 622
Query: 395 LTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKK----PEAPKLS 450
+ + + E+ D + E +D +++SS E E+K P + ++S
Sbjct: 623 MNPGYEVAPRSDSEESDS------------DYEEEDEEEESSRQETEEKILLDPNSEEVS 670
Query: 451 KKKLRRM 457
+K +++
Sbjct: 671 EKDAKQI 677
Score = 32.0 bits (71), Expect = 2.6
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 677 ETGKPLYGDVFGTNAAEFQTKTEEEE-IDRTPWGELEPSDEESSEEEEEEESDEDKPDET 735
ETGK L+G A++ E + P + E SD + EE+EEEES + +E
Sbjct: 601 ETGKVLFGPE-APKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEK 659
Query: 736 GFITP 740
+ P
Sbjct: 660 ILLDP 664
Score = 32.0 bits (71), Expect = 2.6
Identities = 38/202 (18%), Positives = 79/202 (39%), Gaps = 33/202 (16%)
Query: 285 EEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSS 344
E+ N ++ EEE+ R + ++ V +KK + R + P+ + +++
Sbjct: 1330 EDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMNA 1389
Query: 345 ESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKE 404
D + S G +++ E PE YE ++ + K+ + ++ K
Sbjct: 1390 II--DTVINYKDSSGRQLSEVFIQLPSRKELPEYYE----LIRKPVDFKKIKERIRNHKY 1443
Query: 405 KEPEKLDK-------------LENS--------------AAPKKKGFEEEHKDSDDDSSD 437
+ L+K LE S +A +K EEE +D ++ +
Sbjct: 1444 RSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEE 1503
Query: 438 DEQEKKPEAPKLSKKKLRRMNR 459
+E E++ E+ S K ++N+
Sbjct: 1504 EEDEEESESEAKSVKVKIKLNK 1525
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/128 (36%), Positives = 53/128 (41%), Gaps = 18/128 (14%)
Query: 15 LPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRG-- 72
LPPPPPP G + PI G + L GI P RG
Sbjct: 313 LPPPPPPSRGGNQLPRP----------PIVGGNKGRSGPLPPVP--LGIAPPPPTPRGPP 360
Query: 73 ---EDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLG-FPMAHPPNLG 128
G PPP + + +P PPP G PP+ PPPPPPPPPP G G P PP L
Sbjct: 361 PPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV 420
Query: 129 PPPPLRVG 136
P L G
Sbjct: 421 PAGGLAPG 428
Score = 49.3 bits (116), Expect = 2e-05
Identities = 38/92 (41%), Positives = 44/92 (47%), Gaps = 13/92 (14%)
Query: 55 QSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGI--PMPPPPLGLPPLQPPPPP-PPP 111
Q RQ + P RG G++ PP+ G P+PP PLG+ P PPP P PP
Sbjct: 305 QEMRRQEPLPPPPPPSRG--GNQLPRPPIVGGNKGRSGPLPPVPLGIAP--PPPTPRGPP 360
Query: 112 PPGLGLGFPMAHPPNLG-----PPPPLRVGEP 138
PPG G G P PP G PPPP G P
Sbjct: 361 PPGRG-GPPPPPPPATGRSGPLPPPPPGAGGP 391
Score = 42.0 bits (97), Expect = 0.003
Identities = 49/189 (25%), Positives = 75/189 (39%), Gaps = 17/189 (8%)
Query: 75 GDKAAPP--PMSAQLPGIPMPPPPLGLPPLQP-PPPPPPPPPGLGLGFPMAHPPNLGPPP 131
GD+ PP P+S L + + P + + P P P P G ++G P
Sbjct: 183 GDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGAPS 242
Query: 132 PLRVGEPVALSEEERLKLAQQQAAL--LMQQEERAKQQ---GDHSLKEHELLEQQKRAAV 186
+ V + + L L + ++ Q + S ++ +E Q
Sbjct: 243 GFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEA 302
Query: 187 LLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTV-LPMGAPVPR 245
+ ++ R+QE P+P PP + G + P P V G GP P V L + P P
Sbjct: 303 VRQEMRRQE------PLPPPPPP-SRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPT 355
Query: 246 PRGPPPPPG 254
PRG PPPPG
Sbjct: 356 PRG-PPPPG 363
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 65.5 bits (158), Expect = 2e-10
Identities = 104/535 (19%), Positives = 211/535 (39%), Gaps = 106/535 (19%)
Query: 79 APPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGL----------GLGFPMAHPPNLG 128
+PPP ++P +P +P + PPPP P L + P+A
Sbjct: 9394 SPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVA---KKA 9450
Query: 129 PPPPLRVGEPVALSE-----EERLKLA-----------------------QQQAALLMQQ 160
PPP V + + E EE+L A ++ ++ + +
Sbjct: 9451 PPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYR 9510
Query: 161 EERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLG 220
EE +++ + + E+E++E+ + V +E+ I+K P + + + L
Sbjct: 9511 EEEREEEEEAEVTEYEVMEEPEEYVV---EEKLHIISKRVEAEPAEVTERQE--KKIVLK 9565
Query: 221 PRVAAPVGPVGPTPTVLP-----------MGAPVPRPRGPPPP--PGDENREMDDPSVGP 267
P++ A + P P +P + APVP+ PPP P + + + + V P
Sbjct: 9566 PKIPAKIEE--PPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPP 9623
Query: 268 KIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKR 327
K+ + +E+ L K + + M QEE+ + + A EE +V +EK K
Sbjct: 9624 KVIK-MEEPLPAKVT-ERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAV-PEEKVLKL 9680
Query: 328 RNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFK 387
+ +++++ P +V + + + P +V I EE E
Sbjct: 9681 KPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTI---MEEKE---------- 9727
Query: 388 RIFEAFKLTDD-VKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEA 446
A+ L ++ V ++E+E E+ ++ + K FEE + D ++ +E++ E
Sbjct: 9728 ---RAYTLEEEAVSVQREEEYEEYEEYD------YKEFEEYEPTEEYDQYEEYEEREYE- 9777
Query: 447 PKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKAT-RNSVPVPRHWC 505
+ + K + +P E + P V KA VPVP
Sbjct: 9778 ------RYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPI--- 9828
Query: 506 FKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPK 560
+ ++ PP ++P+ K+ +++R ++ ++E+++ + + ++PK
Sbjct: 9829 --------PKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPK 9875
Score = 60.1 bits (144), Expect = 9e-09
Identities = 124/602 (20%), Positives = 227/602 (37%), Gaps = 75/602 (12%)
Query: 77 KAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVG 136
+ PPP +LP P P +P + PP P P + P P P P+
Sbjct: 9281 RVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEV----PKKPVPEEKKPVPVPKK 9336
Query: 137 EPVA---LSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQ 193
EP A + E + + +++ + + +++ A +++ + E+ + ++ ++E
Sbjct: 9337 EPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEE--KITIVTQREES 9394
Query: 194 -----QEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRG 248
EI K P R P + V P P+V P P P P + PVP +
Sbjct: 9395 PPPAVPEIPKKKVPEERKPVPRKEEEVPPP--PKV--PALPKKPVPEE-KVAVPVPVAKK 9449
Query: 249 PPPPPG--------DENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA 300
PPP +E R + + + +PQ +E + + + S +EE + +EEE +
Sbjct: 9450 APPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVE-VTRHEVSAEEEWSYSEEEEGVSI-- 9506
Query: 301 RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKK----PQRVRGVSSESSGDREKDSTR 356
S+ + EE+ V++ E + ++K +RV +E + +EK
Sbjct: 9507 --SVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVL 9564
Query: 357 SRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENS 416
P +IE E P P K+I K+ V K+++ P K+ +
Sbjct: 9565 -----KPKIPAKIE---EPPPAKVPEAP--KKIVPEKKVPAPVPKKEKVPPPKVPEEPKK 9614
Query: 417 AAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVE 476
P+KK + K +E P ++ + + VA K+ V
Sbjct: 9615 PVPEKKVPPKVIK---------MEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVP 9665
Query: 477 MHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEM 536
A + ++ LK R P + F+++ ++ ++ + P P IK I E
Sbjct: 9666 EEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEE 9725
Query: 537 REALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKE 596
+E EE+ S RE+ +Y++ + +K + + T D Y E +E
Sbjct: 9726 KERAYTLEEEAV--SVQREE----------EYEEYEEYDYKEFEEYEPTEEYDQYEEYEE 9773
Query: 597 FETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSP 656
E E+ +++ P P K P + + PP +P P
Sbjct: 9774 REYERYEEHEEYITE--------PEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVP 9825
Query: 657 IP 658
+P
Sbjct: 9826 VP 9827
Score = 53.9 bits (128), Expect = 6e-07
Identities = 72/297 (24%), Positives = 117/297 (39%), Gaps = 31/297 (10%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVL 65
P P +AE PPP A +E A E P+ E V I+
Sbjct: 10791 PVPERAES--PPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIP 10848
Query: 66 NR--PVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPP-PPGLGLG---F 119
+ PV++ + APPP P P + P L+P PPPPPP PP + F
Sbjct: 10849 EKKVPVIKKPE----APPPKE------PEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIF 10898
Query: 120 PMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLE 179
+ P P +V E V L+ LK+ + + ER + + + + L +
Sbjct: 10899 QLKAIPKKKVPEKPQVPEKVELTP---LKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRK 10955
Query: 180 QQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLP- 238
+ + +E ++ +++ K P P PP+ + ++ V P V + P PT +P
Sbjct: 10956 RPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEV-----PTVTKRERKI-PEPTKVPE 11009
Query: 239 --MGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEE 293
P+P P P P P E + + P V P+ + ++ E + +EE
Sbjct: 11010 IKPAIPLPAPE-PKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEE 11065
Score = 49.7 bits (117), Expect = 1e-05
Identities = 114/546 (20%), Positives = 213/546 (39%), Gaps = 70/546 (12%)
Query: 76 DKAAPPPMSAQLPGIPMPP--PPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPL 133
+K PP ++ +PP PP + P + PP P P + P PP
Sbjct: 10434 EKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPT 10493
Query: 134 RVGE---PVALSEEERLKL--AQQQAALLMQQEERAKQQGDHSL------KEHEL----L 178
+V E P + E+++ + A++ A + E K+ K+ E+ +
Sbjct: 10494 KVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKV 10553
Query: 179 EQQKRAAVLLEQERQQEIAKMGTP---VPRPPQDM---GQIGVRTPLGPRVAAPVGPVGP 232
+ +AAV ++ + K +P VP P+++ ++ P P V P P
Sbjct: 10554 PEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAP 10613
Query: 233 TPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQE 292
V PVP P+ P PP + + P V + E I ES E+ + E
Sbjct: 10614 KEVVPEKKVPVPPPKKPEVPP---TKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPE 10670
Query: 293 EEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQ----RVRGVSSESSG 348
E +E + + KK K+ KKP+ +V V E
Sbjct: 10671 EVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVP 10730
Query: 349 DREKDSTRSRGSDSPAADV-EI-EYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKE 406
+++ + ++P A V E+ + V E ++ P K K+ + KK +E
Sbjct: 10731 EKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPK----KPEVPPAKVPEVPKKPVLEE 10786
Query: 407 PEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEK--------KPEA--PKLSKKKLRR 456
+ E + +P + +EE + + ++ E+EK +PE P + ++ +
Sbjct: 10787 KPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKI 10846
Query: 457 MNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVP-------RHWCFKRK 509
+ V +K+ A P + + PKL R P P + F+ K
Sbjct: 10847 IPEKKVPVIKKPEAPPPKEPEPEKVIEKPKL-----KPRPPPPPPAPPKEDVKEKIFQLK 10901
Query: 510 YLQGKRGIEKPPFELPDFIKRT------GIQEMREALQEK----EEQKTMKSKMREKVRP 559
+ K+ EKP ++P+ ++ T G +++R+ L E+ +E+ +KS +R++
Sbjct: 10902 AIPKKKVPEKP--QVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEE 10959
Query: 560 KMGKID 565
+ K++
Sbjct: 10960 EEPKVE 10965
Score = 48.5 bits (114), Expect = 3e-05
Identities = 165/865 (19%), Positives = 309/865 (35%), Gaps = 167/865 (19%)
Query: 120 PMAHPPNLGPPPPLRVGEPV--------ALSEEERL---KLAQQQAALLMQQEERAKQQ- 167
P P PPPP + +PV EEE++ K+ + ++ Q+ R Q
Sbjct: 9166 PAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQE 9225
Query: 168 ------------------------GDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPV 203
H+ +E + + + ++ E++ I+K P
Sbjct: 9226 EVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPP 9285
Query: 204 PRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDP 263
P+ P+ + + V P P +P PVP + P P P E P
Sbjct: 9286 PKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPK-KPVPEEKKPVPVPKKE------P 9338
Query: 264 SVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEK 323
+ PK+P+ +K + +E++ +++ A+ Q TEE V+++E+
Sbjct: 9339 AAPPKVPEVPKKPVP-----EEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREE 9393
Query: 324 N---------RKRRNRKKKKKPQRVRGVS--------SESSGDREKDSTR---SRGSDSP 363
+ +K+ ++K P++ V + EK + ++ + P
Sbjct: 9394 SPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPP 9453
Query: 364 AADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKG 423
A+V + V EE KR KL+ V + E + + E SA +
Sbjct: 9454 RAEVSKKTVVEE-----------KRFVAEEKLSFAVPQRVE-----VTRHEVSAEEEWSY 9497
Query: 424 FEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQ 483
EEE S ++E+E++ EA + + + V E ++++ E +VT +
Sbjct: 9498 SEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTER 9557
Query: 484 DPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEK 543
K +V + +P E PP ++P+ K+ ++ A K
Sbjct: 9558 QEKKIV----LKPKIPAKIE--------------EPPPAKVPEAPKKIVPEKKVPAPVPK 9599
Query: 544 EE--------QKTMKSKMREKVRPKMGKIDIDY-QKLHDAFFKWQTKPKLTIHGDLYYEG 594
+E ++ K +KV PK+ K++ K+ + + + K+ +
Sbjct: 9600 KEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLV------AV 9653
Query: 595 KEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLN 654
+ E K + P + + + + P + PP + ++ +++ P
Sbjct: 9654 TKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKRE 9713
Query: 655 -SPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEE---EIDRTPWGE 710
PI E + E + Y A Q + E E E D + E
Sbjct: 9714 PQPIKE-------------VTIMEEKERAY--TLEEEAVSVQREEEYEEYEEYDYKEFEE 9758
Query: 711 LEPSDEESSEEEEEEESDEDKPDETGFITPADSGL-ITPGGFSSVPAGMETPELIELRKK 769
EP++E EE EE E + +IT + + + P VP + P L+K
Sbjct: 9759 YEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKA 9818
Query: 770 KIEEAMD---------------------GSETPQLFTVLPEKRTATVGGA---MMGSTHI 805
EE + E ++ EK T A M +
Sbjct: 9819 VPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVV 9878
Query: 806 YDMSTVMSRKGPAPELQGVEV--ALAPEELELDPMAMTQKYEEHVREQQAQV-EKEDF-- 860
+ + RK AP ++ EV L PEE+ + +T E V E++ + E+E+F
Sbjct: 9879 AEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFIT 9938
Query: 861 -SDMVAEHAAKQKQKKRKAQPQDSR 884
++V K + RK P++ +
Sbjct: 9939 EEEVVPVIPVKVPEVPRKPVPEEKK 9963
Score = 48.5 bits (114), Expect = 3e-05
Identities = 107/446 (23%), Positives = 176/446 (39%), Gaps = 47/446 (10%)
Query: 79 APPPMSAQLPGIPMPPPPLGL-PPLQPPPPPP-----PP---PPGLGLGFPMAHPPNLGP 129
A PP ++ + +P P + P + P PPP PP P + P P P
Sbjct: 10596 AAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIP 10655
Query: 130 PPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLE 189
P P P E E + L + A ++ + E A Q ++ + + ++K AV+
Sbjct: 10656 PKP-ESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQ--VTVPPKKPVPEKKAPAVV-- 10710
Query: 190 QERQQEIAKMGTP-VPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRG 248
++ E+ + P VP+ ++ + P P AP V P + V P+
Sbjct: 10711 -AKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPE--APPAKVPEVPKEVVPEKKVAVPKK 10767
Query: 249 PPPPPGDENREMDDPSVGPKIPQALEK----ILQLKESRQEEMNSQQEE--EEMETDARS 302
P PP P V PK P EK + + ES E+ + EE E E
Sbjct: 10768 PEVPPAKV------PEV-PKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEE 10820
Query: 303 SLGQSASETEEDTVSVSKKEKNRKRRNRKKK----KKPQRVRGVSSESSGDREKDSTRSR 358
+E EE V + K+ +KK KKP+ E EK + R
Sbjct: 10821 EKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPR 10880
Query: 359 GSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAA 418
P A + E V E +I++ I K++ E ++ + V+ K P +K
Sbjct: 10881 PPPPPPAPPK-EDVKE--KIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGG-EKKVRKLL 10936
Query: 419 PKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARP-DVVEM 477
P++K E K+ S + + E PK+ KKL ++ + V E +P + VE+
Sbjct: 10937 PERK---PEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPP--PKPVEEVEV 10991
Query: 478 HDVTAQDPKLLVHLKA--TRNSVPVP 501
VT ++ K+ K + ++P+P
Sbjct: 10992 PTVTKRERKIPEPTKVPEIKPAIPLP 11017
Score = 44.7 bits (104), Expect = 4e-04
Identities = 168/867 (19%), Positives = 305/867 (35%), Gaps = 181/867 (20%)
Query: 80 PPPMSAQLPGIPMPPPPLGLPPLQPPPPPPP-----PPPGLGLGFPMAHPPNLGPPPPLR 134
P P + P +P P L P + P P P PPP + P P P+
Sbjct: 10048 PAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKV---------PKKREPVPV- 10097
Query: 135 VGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQER-- 192
PVAL +EE + ++ ++ +EE ++ + +E E+L +++ VL E+E
Sbjct: 10098 ---PVALPQEEEVLFEEE----IVPEEEVLPEEEEVLPEEEEVLPEEEE--VLPEEEEIP 10148
Query: 193 --QQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVG------PVGPTPTVLPMGAPVP 244
++E+ VP + + + V + P+V P V V+P P
Sbjct: 10149 PEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAP 10208
Query: 245 RPRGPPPP-----------------PGDENREMDDPSVG----PKIPQALEKILQLKESR 283
+ P P P + E ++ + P+ P ++E++ ++ R
Sbjct: 10209 PAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPR 10268
Query: 284 QEEMNSQQEEEE-----METDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQR 338
E+ + E + +A + E+ V V KKE + KK P++
Sbjct: 10269 VPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEK 10328
Query: 339 VRGVSSESSGDREKDSTRSRGSDSPA---------------ADVEIEYVTEEPEIYEPNF 383
V + + K T S A + E+E + EE E +E
Sbjct: 10329 KVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEE 10388
Query: 384 IFFK---------------------------RIFEAFKLTDDVKKEKEKEPEKLDKLENS 416
F + R+ E F+ + EK K P K ++
Sbjct: 10389 YFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEK 10448
Query: 417 AAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPK--LSKKKLRRMNRFTVAELKQLVARPDV 474
P KK + + K PE PK + ++K+R V K P+V
Sbjct: 10449 IIPPKK------PPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKV----PEV 10498
Query: 475 VEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQ 534
+ +V + K + A + P P+ ++ + K+ + PP + P+ + T +
Sbjct: 10499 LPPKEVVPE--KKVPVPPAKKPEAPPPKVPEAPKEVVPEKK-VPVPPPKKPE-VPPTKVP 10554
Query: 535 EM-REALQEKEEQKTMKSKMREKVR--PKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLY 591
E+ + A+ EK+ + + K P+ K + +K+ A K KP++T
Sbjct: 10555 EVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPK---KPEVT------ 10605
Query: 592 YEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIP 651
++ E P ++ E ++ + P P +VPP + + P + P K+P
Sbjct: 10606 ------PVKVPE-APKEVVPEKKVPVPPPKKP---EVPPTKVPEV----PKVAVPEKKVP 10651
Query: 652 GLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGEL 711
P PES PP + +P EE ++ P E+
Sbjct: 10652 EAIPPKPES------------PPPEVFEEP-----------------EEVALEEPP-AEV 10681
Query: 712 EPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKI 771
E ++ + + P++ A + P VP + + + L K
Sbjct: 10682 VEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKK 10741
Query: 772 EEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPE 831
EA V+PEK+ A + + ++ P L+ PE
Sbjct: 10742 PEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVP-------KKPVLEEKPAVPVPE 10794
Query: 832 ELELDPMAMTQKYEEHVREQQAQVEKE 858
E P + ++ EE E++ E+E
Sbjct: 10795 RAESPPPEVYEEPEEIAPEEEIAPEEE 10821
Score = 42.0 bits (97), Expect = 0.003
Identities = 83/446 (18%), Positives = 151/446 (33%), Gaps = 78/446 (17%)
Query: 67 RPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPP----------------- 109
+PV K PP +P P+ +P PPPP
Sbjct: 9796 KPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISI 9855
Query: 110 ---------------PPPPGLGLGFPMAHPPNLGPPPPLRVGE-PVALSEEERLKLAQQQ 153
P P + P PP+RV E P L EE +A ++
Sbjct: 9856 TKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEE---VAFEE 9912
Query: 154 AALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQI 213
+ +E +++ ++ +E E + +++ V+ + E+ + P + P
Sbjct: 9913 EVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVI--PVKVPEVPRKPVPEEKKP------ 9964
Query: 214 GVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQAL 273
P+ + AP V P PV P+ PPP P K+P +
Sbjct: 9965 ---VPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPV 10021
Query: 274 EKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKK 333
K ++ ++ E+ + E + + + E V + K +K
Sbjct: 10022 PKKVEAPPAKVPEVPKKPVPE------KKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPT 10075
Query: 334 KKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAF 393
P++V + RE V + EE ++E + + +
Sbjct: 10076 PVPKKVEAPPPKVPKKRE------------PVPVPVALPQEEEVLFEEEIVPEEEV---- 10119
Query: 394 KLTDDVKKEKEKEPEKLDKL--ENSAAPKKKGF--EEEHKDSDDDSSDDEQEKKPEAPKL 449
+ +E+E PE+ + L E P+++ EEE +++ +E+E PE L
Sbjct: 10120 -----LPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVL 10174
Query: 450 SKKKLRRMNRFTVAELKQLVARPDVV 475
+ K + V E+K+ V VV
Sbjct: 10175 PEVKPKVPVPAPVPEIKKKVTEKKVV 10200
Score = 38.5 bits (88), Expect = 0.028
Identities = 102/481 (21%), Positives = 180/481 (37%), Gaps = 82/481 (17%)
Query: 87 LPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEER 146
+P IP+ P + P +P P P P P PP +V E EE+
Sbjct: 9943 VPVIPVKVPEV---PRKPVPEEKKPVP----------VPKKKEAPPAKVPEVPKKPEEK- 9988
Query: 147 LKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRP 206
+L+ ++E+ + + + E+ + V + ++ + AK+ VP+
Sbjct: 9989 -------VPVLIPKKEKPPPAKVPEVPKKPVPEE--KVPVPVPKKVEAPPAKV-PEVPKK 10038
Query: 207 PQDMGQIGVRTPLGPRVAAPVGPVGPTPTVL--PMGAPVPRPRGPPPPPGDENREMDDPS 264
P ++ V P +V AP V P L P P P+ PP ++ +
Sbjct: 10039 PVPEKKVPVPAP--KKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVP 10096
Query: 265 VGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKN 324
V +PQ E++L +E EE +EEE + + + EE+ + ++E
Sbjct: 10097 VPVALPQE-EEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEV- 10154
Query: 325 RKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFI 384
+++ P+ V E K PA EI+ E ++ P
Sbjct: 10155 ----PPEEEYVPEEEEFVPEEEVLPEVKPKV-----PVPAPVPEIKKKVTEKKVVIPK-- 10203
Query: 385 FFKRIFEAFKLTDDVKKEKEK-----EPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDD- 438
K K+ + KK +EK + E++ +E + P+++ EE + S ++
Sbjct: 10204 --KEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEV 10261
Query: 439 EQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSV 498
E+ P P++ KK A P+ + P V K V
Sbjct: 10262 EEVAPPRVPEVIKK-----------------AVPEAPTPVPKKVEAPPAKVSKKIPEEKV 10304
Query: 499 PVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSK--MREK 556
PVP +Q K E PP ++P+ K+ + E + + +KE K + + EK
Sbjct: 10305 PVP---------VQKK---EAPPAKVPEVPKK--VPEKKVLVPKKEAVPPAKGRTVLEEK 10350
Query: 557 V 557
V
Sbjct: 10351 V 10351
Score = 35.4 bits (80), Expect = 0.24
Identities = 171/860 (19%), Positives = 302/860 (35%), Gaps = 205/860 (23%)
Query: 77 KAAPPPMSAQLPGIPMPPPPLGLPPLQPPPP------PPPPPPGLGLGFPMAH----PPN 126
K APP ++P P P+ +P + PPP P P P + P+ PP
Sbjct: 9971 KEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPA 10030
Query: 127 LGP---------------------PPPLRVGE-PVALSEEER------------------ 146
P PP +V E P L EE+
Sbjct: 10031 KVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPK 10090
Query: 147 --------LKLAQQQAAL----LMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQE--- 191
+ L Q++ L ++ +EE ++ + +E E+L +++ VL E+E
Sbjct: 10091 KREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEE--VLPEEEEIP 10148
Query: 192 -RQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPP 250
++E+ VP + + + V + P+V P V +P+ P
Sbjct: 10149 PEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAP 10208
Query: 251 PPPGDENREMDDPSVGPKIPQALE--KILQLKESR--QEEMNSQQEEEEMETDARSSLGQ 306
P+ P++P+ +E +I+ KE E+ + EEE + +
Sbjct: 10209 ------------PAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP 10256
Query: 307 SASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSG--DREKDSTRSRGSDSPA 364
S E EE E +K P++V ++ S EK + ++P
Sbjct: 10257 SIEEVEE-VAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPP 10315
Query: 365 ADV-EIEYVTEEPEIYEP----------NFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKL 413
A V E+ E ++ P + +++ AF+ VK+ E E + +
Sbjct: 10316 AKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELE---VVEA 10372
Query: 414 ENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPD 473
E P+ EEE + ++ + E + E KL + ++ +R V +
Sbjct: 10373 EVEEIPE----EEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAE 10428
Query: 474 VVEMHDVTAQDPK------LLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDF 527
VE+ + PK ++ K V VPR ++PP ++P+
Sbjct: 10429 EVEVFEKPKAPPKGPEISEKIIPPKKPPTKV-VPR---------------KEPPAKVPEV 10472
Query: 528 IKRTGIQEMREALQEKEEQKTMKSKMREKVRPK----MGKIDIDYQKLHDAFFKWQTKPK 583
K+ ++ E ++ EE + +K+ E + PK K+ + K +A PK
Sbjct: 10473 PKKIVVE---EKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEA-----PPPK 10524
Query: 584 LTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPP 643
+ + P ++ E ++ + P P +VPP + + P
Sbjct: 10525 V------------------PEAPKEVVPEKKVPVPPPKKP---EVPPTKVPEV----PKA 10559
Query: 644 SYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEI 703
+ P K+P P PES P V E K + + A + + ++
Sbjct: 10560 AVPEKKVPEAIPPKPES----------PPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKV 10609
Query: 704 DRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGL---ITPGGFSSVPAGMET 760
P E+ P + ++ E K E + + + I P S P E
Sbjct: 10610 PEAP-KEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEE 10668
Query: 761 PELIELRKKKIE--EAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPA 818
PE + L + E E + + PQ+ TV P+K V +K PA
Sbjct: 10669 PEEVALEEPPAEVVEEPEPAAPPQV-TVPPKK-------------------PVPEKKAPA 10708
Query: 819 -----PELQGVEVALAPEEL 833
PEL V+V P+E+
Sbjct: 10709 VVAKKPELPPVKVPEVPKEV 10728
Score = 32.0 bits (71), Expect = 2.6
Identities = 37/148 (25%), Positives = 58/148 (39%), Gaps = 24/148 (16%)
Query: 103 QPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVG---------EPVALSEEERLKLAQQQ 153
Q P PP PP + + P A + PPL G E +A EER K +
Sbjct: 14574 QDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIA-KGEERWKRCNEH 14632
Query: 154 AALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQI 213
++ + ++G KE++ + + AA + E R K P+ P ++
Sbjct: 14633 LVPILTYTAKGLEEG----KEYQFRVRAENAAGISEPSRATPPTKAVDPIDAP-----KV 14683
Query: 214 GVRTPL----GPRVAAPVGPVG-PTPTV 236
+RT L G +A G P PT+
Sbjct: 14684 ILRTSLEVKRGDEIALDASISGSPYPTI 14711
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 65.1 bits (157), Expect = 3e-10
Identities = 71/259 (27%), Positives = 88/259 (33%), Gaps = 27/259 (10%)
Query: 8 PPKAELQLPPPPPPGHYGAWAAQELQAKLAE-----IGAPIQGNREELVERLQSYTRQTG 62
PP + L P P P A A LQA + + AP V + Q
Sbjct: 640 PPLSPLATPSPQAPN---ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 696
Query: 63 IVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMA 122
L P L+ A+PP MS P PPPL PPLQ PP PP PP P
Sbjct: 697 PSLAAPPLQVPPSPPASPP-MSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPP 755
Query: 123 HPPNLGPPPPLRV--GEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ 180
P L PPL+V P +L K Q L +A S
Sbjct: 756 RVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFP------- 808
Query: 181 QKRAAVLLEQERQQEIAKMGTPVPRPPQDMG----QIGVRTPLGPRVAAPVGPVGPTPTV 236
++ + TP P+ P + Q+ P P + AP P P P
Sbjct: 809 ---GQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 865
Query: 237 LPMG--APVPRPRGPPPPP 253
G + GPPPPP
Sbjct: 866 SVSGPRLTLALAPGPPPPP 884
Score = 55.1 bits (131), Expect = 3e-07
Identities = 80/313 (25%), Positives = 101/313 (32%), Gaps = 62/313 (19%)
Query: 6 PEPPKAELQLPPPP----PPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQT 61
P P LQ PP P PP + A QA A P+QG + L + Q
Sbjct: 562 PCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQA 621
Query: 62 GIVLNRPVLRGEDGDKAAPP--PMSAQLPGIP------------MPPP------------ 95
L P L+ A+PP P++ P P PPP
Sbjct: 622 PPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 681
Query: 96 -----PLGLPPLQPPP----PP---PPPPPGLGLGFPMAHPPNLGPP----PPLRV--GE 137
P PP Q PP PP PP PP P A PP PP PPL+V
Sbjct: 682 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSP 741
Query: 138 PVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIA 197
P + + LL + SL L + +A L Q +
Sbjct: 742 PASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQAL- 800
Query: 198 KMGTPVPRPPQDM-GQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDE 256
P PP GQ P P + P+ P+ P P P + PP PP
Sbjct: 801 ------PSPPASFPGQ----APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 850
Query: 257 NREMD--DPSVGP 267
+ P+ GP
Sbjct: 851 TLQAPRRPPTPGP 863
Score = 43.9 bits (102), Expect = 7e-04
Identities = 59/202 (29%), Positives = 68/202 (33%), Gaps = 25/202 (12%)
Query: 79 APPPM---SAQL--PGIPMPPPPLGLPPLQPPPP---PPPPPPGLGLGFPMAHPPNLGPP 130
APPP+ SA L P + PP P P PP P PPP P P PP L P
Sbjct: 542 APPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASP 601
Query: 131 PPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQ 190
P + P A AL Q A S L +A L
Sbjct: 602 PLQGLPSPPLSPLATPPPQAPPXLALPPLQ---APPSPPASPPLSPLATPSPQAPNALAV 658
Query: 191 ERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPP 250
Q +P P PP V+ P P + PV P P+ P P + PP
Sbjct: 659 HLLQ---APFSPPPSPP-------VQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708
Query: 251 PPPGDENREMDDPSVGPKIPQA 272
PP PS P PQA
Sbjct: 709 SPPASPPM---SPSATPP-PQA 726
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/184 (24%), Positives = 64/184 (34%), Gaps = 31/184 (16%)
Query: 77 KAAPPPMSAQ--LPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGP----- 129
+ PPP +A LP P PPL P PP P PP L P A PP+ P
Sbjct: 315 RPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTT 374
Query: 130 -----PPPLRVGEPVALSEE-ERLKLAQQQAALLMQQEERAKQQGDHSLK-EHELLEQQK 182
PP L+ P+ + L + L + + G +L+ H L
Sbjct: 375 PPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSP 434
Query: 183 RAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGP---VGPTPTVLPM 239
R + Q + P PP PL ++ P P +P V P+
Sbjct: 435 R-------QTQASLTSPSRPASTPPDS-------PPLQAPLSLPASPPLQTSLSPAVSPL 480
Query: 240 GAPV 243
+P+
Sbjct: 481 SSPL 484
Score = 37.4 bits (85), Expect = 0.063
Identities = 52/223 (23%), Positives = 70/223 (31%), Gaps = 36/223 (16%)
Query: 84 SAQLPGIPMPP---------PPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLR 134
S PG P P +GLP P P PP G A + P P
Sbjct: 165 SGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA 224
Query: 135 VGEPVA------------------LSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHE 176
P A LS R + + + K +G +L+ +
Sbjct: 225 RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ 284
Query: 177 LLEQQKRAAVLLEQERQQEIAK---MGT---PVPRPPQDMGQIGVRTPLGPRVAAPVGPV 230
+ +K AA L +A GT PVP P + P P +A P+
Sbjct: 285 VTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLA 344
Query: 231 GPTPTVLPMGAPVPRPRGPPP---PPGDENREMDDPSVGPKIP 270
P+P+ P +P P PP PP M P IP
Sbjct: 345 PPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387
Score = 36.6 bits (83), Expect = 0.11
Identities = 43/176 (24%), Positives = 59/176 (33%), Gaps = 15/176 (8%)
Query: 78 AAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGE 137
A P P + P+PPP PL PP PP L P+A P PP +
Sbjct: 305 ATPSPSGTKAR--PVPPPDNAATPLPATLPPSPP---LATPLPLAPPSPSAPPSLQTLPS 359
Query: 138 PVALSEEE---RLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQ 194
P A + + QA +Q Q HSL L A+ Q
Sbjct: 360 PPATPPSQAPPSMTTPPMQAPPSLQTIPPI--QVPHSLTSPSLQAPPSPLAL----SSLQ 413
Query: 195 EIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPP 250
+G+P + + R + +P P P P+ AP+ P PP
Sbjct: 414 ATTSLGSPTLQATHSFLTMSPRQTQA-SLTSPSRPASTPPDSPPLQAPLSLPASPP 468
Score = 35.4 bits (80), Expect = 0.24
Identities = 41/150 (27%), Positives = 54/150 (36%), Gaps = 13/150 (8%)
Query: 6 PEPPKAELQLPP--PPPPGHYGAWAAQELQAKLAEIG-----APIQGNREELVERLQSYT 58
P P A L + P PPP A A LQA + AP + + L +
Sbjct: 769 PPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPP 828
Query: 59 RQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLG 118
Q VL P+L+ A+P + + P P P + P L P PPPP
Sbjct: 829 PQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP----- 883
Query: 119 FPMAHPPNLGPPPPLRVGEPVALSEEERLK 148
P P + P L A S E L+
Sbjct: 884 -PSRSPSSTLSGPDLAGHSSSATSTPEELR 912
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 64.7 bits (156), Expect = 4e-10
Identities = 66/242 (27%), Positives = 92/242 (38%), Gaps = 43/242 (17%)
Query: 30 QELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPG 89
Q+L+A+++++ + +EL + + + + P AP P + LPG
Sbjct: 526 QDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP----PSVPSRAPVPPAPPLPG 581
Query: 90 -----IPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNL------GPPPPL----R 134
IP PP P PPPPPPPPPP L G ++ PP+L PPPPL
Sbjct: 582 DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDAT 641
Query: 135 VGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQ 194
+ P L E + + G ++ L R +
Sbjct: 642 IPPPPPLPEGVGI-------------PSPSSLPGGTAIPPPPPLPGSAR----IPPPPPP 684
Query: 195 EIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRP---RGPPP 251
G P P PP G+ G+ P P P GP P P P G +P P G PP
Sbjct: 685 LPGSAGIPPPPPPLP-GEAGMPPPPPP---LPGGPGIPPPPPFPGGPGIPPPPPGMGMPP 740
Query: 252 PP 253
PP
Sbjct: 741 PP 742
Score = 61.6 bits (148), Expect = 3e-09
Identities = 46/133 (34%), Positives = 53/133 (39%), Gaps = 6/133 (4%)
Query: 2 ATEHPEPPKAELQLPPPPP-PGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ 60
A P P + +PPPPP P G + L A P +
Sbjct: 629 AISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGS 688
Query: 61 TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPP----PPPPPPGLG 116
GI P L GE G PPP+ PGIP PPP G P + PPPP PPPPP G G
Sbjct: 689 AGIPPPPPPLPGEAGMPPPPPPLPGG-PGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFG 747
Query: 117 LGFPMAHPPNLGP 129
+ P L P
Sbjct: 748 VPAAPVLPFGLTP 760
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/163 (33%), Positives = 64/163 (39%), Gaps = 34/163 (20%)
Query: 3 TEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTG 62
T P PP PPPP PG + L A I P + + + G
Sbjct: 598 TPPPPPPPPP---PPPPLPGGVCISSPPSLPGGTA-ISPPPPLSGDATIPPPPPLPEGVG 653
Query: 63 IVLNRPVLRGEDGDKAAPPPM----SAQLP----------GIPMPPPPL-GLPPLQPPPP 107
I P G A PPP SA++P GIP PPPPL G + PPPP
Sbjct: 654 I----PSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 709
Query: 108 PPPPPPGL--------GLGFPMAHPPNLG--PPPPLRVGEPVA 140
P P PG+ G G P PP +G PPPP G P A
Sbjct: 710 PLPGGPGIPPPPPFPGGPGIP-PPPPGMGMPPPPPFGFGVPAA 751
Score = 37.7 bits (86), Expect = 0.048
Identities = 34/147 (23%), Positives = 56/147 (38%), Gaps = 10/147 (6%)
Query: 134 RVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLK------EHELLEQQKRAAVL 187
+V + A + E KL + A Q E K + D K E + L +K+
Sbjct: 464 KVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIAT 523
Query: 188 LEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPR 247
+Q+ + E++++ V + +++ A V P P+ +P P+P
Sbjct: 524 EKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDS 583
Query: 248 G----PPPPPGDENREMDDPSVGPKIP 270
G PPP PGD P P P
Sbjct: 584 GTIIPPPPAPGDSTTPPPPPPPPPPPP 610
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 64.7 bits (156), Expect = 4e-10
Identities = 66/242 (27%), Positives = 92/242 (38%), Gaps = 43/242 (17%)
Query: 30 QELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPG 89
Q+L+A+++++ + +EL + + + + P AP P + LPG
Sbjct: 535 QDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP----PSVPSRAPVPPAPPLPG 590
Query: 90 -----IPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNL------GPPPPL----R 134
IP PP P PPPPPPPPPP L G ++ PP+L PPPPL
Sbjct: 591 DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDAT 650
Query: 135 VGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQ 194
+ P L E + + G ++ L R +
Sbjct: 651 IPPPPPLPEGVGI-------------PSPSSLPGGTAIPPPPPLPGSAR----IPPPPPP 693
Query: 195 EIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRP---RGPPP 251
G P P PP G+ G+ P P P GP P P P G +P P G PP
Sbjct: 694 LPGSAGIPPPPPPLP-GEAGMPPPPPP---LPGGPGIPPPPPFPGGPGIPPPPPGMGMPP 749
Query: 252 PP 253
PP
Sbjct: 750 PP 751
Score = 61.6 bits (148), Expect = 3e-09
Identities = 46/133 (34%), Positives = 53/133 (39%), Gaps = 6/133 (4%)
Query: 2 ATEHPEPPKAELQLPPPPP-PGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ 60
A P P + +PPPPP P G + L A P +
Sbjct: 638 AISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGS 697
Query: 61 TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPP----PPPPPPGLG 116
GI P L GE G PPP+ PGIP PPP G P + PPPP PPPPP G G
Sbjct: 698 AGIPPPPPPLPGEAGMPPPPPPLPGG-PGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFG 756
Query: 117 LGFPMAHPPNLGP 129
+ P L P
Sbjct: 757 VPAAPVLPFGLTP 769
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/163 (33%), Positives = 64/163 (39%), Gaps = 34/163 (20%)
Query: 3 TEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTG 62
T P PP PPPP PG + L A I P + + + G
Sbjct: 607 TPPPPPPPPP---PPPPLPGGVCISSPPSLPGGTA-ISPPPPLSGDATIPPPPPLPEGVG 662
Query: 63 IVLNRPVLRGEDGDKAAPPPM----SAQLP----------GIPMPPPPL-GLPPLQPPPP 107
I P G A PPP SA++P GIP PPPPL G + PPPP
Sbjct: 663 I----PSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 718
Query: 108 PPPPPPGL--------GLGFPMAHPPNLG--PPPPLRVGEPVA 140
P P PG+ G G P PP +G PPPP G P A
Sbjct: 719 PLPGGPGIPPPPPFPGGPGIP-PPPPGMGMPPPPPFGFGVPAA 760
Score = 37.7 bits (86), Expect = 0.048
Identities = 34/147 (23%), Positives = 56/147 (38%), Gaps = 10/147 (6%)
Query: 134 RVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLK------EHELLEQQKRAAVL 187
+V + A + E KL + A Q E K + D K E + L +K+
Sbjct: 473 KVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIAT 532
Query: 188 LEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPR 247
+Q+ + E++++ V + +++ A V P P+ +P P+P
Sbjct: 533 EKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDS 592
Query: 248 G----PPPPPGDENREMDDPSVGPKIP 270
G PPP PGD P P P
Sbjct: 593 GTIIPPPPAPGDSTTPPPPPPPPPPPP 619
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 63.9 bits (154), Expect = 6e-10
Identities = 61/217 (28%), Positives = 79/217 (36%), Gaps = 49/217 (22%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVL 65
P PP + PPPPPP H + + A P +
Sbjct: 278 PPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRA-------------------- 317
Query: 66 NRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLG---------LPPLQPPPPPPPPPPGLG 116
AAPPP P + +PPPP LP P PPPPPP LG
Sbjct: 318 ----------PTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLG 367
Query: 117 LGFPMAHPPNLGPPPPLRVGEPVAL---SEEERLKLAQQQAALLMQQEERAK----QQGD 169
+G P+A PP PPPP P L + + A +AALL Q E A+ +Q
Sbjct: 368 VG-PVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNS 426
Query: 170 H--SLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVP 204
S + L Q R + L+ + + TP P
Sbjct: 427 RPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAP 463
Score = 55.8 bits (133), Expect = 2e-07
Identities = 61/223 (27%), Positives = 77/223 (34%), Gaps = 66/223 (29%)
Query: 75 GDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPP--P-PPPPPGLGLGFPMAHP---PNLG 128
G +A + Q P P PPP G PP PPPP PPPPP G G P P P
Sbjct: 264 GVEAVKNELRRQAP--PPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAA 321
Query: 129 PPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLL 188
PPPP VA+ ++ L
Sbjct: 322 PPPPPPSRPSVAVPPPPPNRMYPPPPPALPSS---------------------------- 353
Query: 189 EQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRG 248
A G P P PP +G VGPV P P P P P G
Sbjct: 354 --------APSGPP-PPPPSVLG---------------VGPVAPPPP-----PPPPPPPG 384
Query: 249 PPPPPG-DENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQ 290
PPPPPG + + P+ L++I + + ++ E NS+
Sbjct: 385 PPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSR 427
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 63.5 bits (153), Expect = 8e-10
Identities = 64/229 (27%), Positives = 83/229 (36%), Gaps = 50/229 (21%)
Query: 2 ATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREE-LVERLQSYTRQ 60
A+ +P PP+++ P P +++ L AE P+ R L +S
Sbjct: 243 ASSYPPPPQSDSASSPSP------SFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVS 296
Query: 61 TGIVLNRPVLRGEDGDKA------APPPMSAQLPGIPMPPPPLGL------PPLQPP--- 105
P L G K APPP + GIP PPPP+G PP PP
Sbjct: 297 PSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFP 356
Query: 106 -------PPPPPPPPGL---------------GLGFPMAHPPNLGPPPPLRVGE------ 137
PPPPPPPP G P PP GPPPP G
Sbjct: 357 PHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAI 416
Query: 138 PVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAV 186
P LS+ + K + + A +QG + E EQ+KR V
Sbjct: 417 PPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVV 465
Score = 38.5 bits (88), Expect = 0.028
Identities = 34/102 (33%), Positives = 37/102 (36%), Gaps = 20/102 (19%)
Query: 199 MGTPVPRPPQDMGQIGVRTPLGPR-------VAAPVGPVGPT----PTVLPM-------G 240
+G P P PP G G P P AAP P P PT+ P G
Sbjct: 330 IGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGG 389
Query: 241 APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKES 282
AP P P PPPPPG P IP L + K S
Sbjct: 390 APPPPP--PPPPPGPPPPPFTGADGQPAIPPPLSDTTKPKSS 429
Score = 32.7 bits (73), Expect = 1.5
Identities = 23/63 (36%), Positives = 26/63 (41%), Gaps = 7/63 (11%)
Query: 215 VRTPLGPRVAAPVG-PVGPTPTVLPMGAPVPRPR------GPPPPPGDENREMDDPSVGP 267
V +P P A P+G P GP P P AP P P PPPP G + P P
Sbjct: 294 VVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPP 353
Query: 268 KIP 270
P
Sbjct: 354 SFP 356
Score = 30.4 bits (67), Expect = 7.7
Identities = 32/127 (25%), Positives = 48/127 (37%), Gaps = 15/127 (11%)
Query: 202 PVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVL-PMGAPVP-------RPRGPPPPP 253
P P PP P P ++ P G P P P G P P +P PPP
Sbjct: 364 PPPPPPPPAADYPTLPP--PPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLS 421
Query: 254 GDENREMDDPSVGPKIPQALEKILQ-LKESRQEEMNSQQEEEEMETDARSSLGQ----SA 308
+ P+V L I Q + R EE Q++ + + D + L +
Sbjct: 422 DTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVEY 481
Query: 309 SETEEDT 315
S++E+D+
Sbjct: 482 SDSEDDS 488
>gi|209180481 Cas-Br-M (murine) ecotropic retroviral transforming
sequence-like 1 [Homo sapiens]
Length = 491
Score = 63.2 bits (152), Expect = 1e-09
Identities = 74/289 (25%), Positives = 98/289 (33%), Gaps = 66/289 (22%)
Query: 8 PPKAELQLPPPP----PPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGI 63
PPK + +PPPP P HY ++++A AE+ R E + TR+
Sbjct: 233 PPKQHIMMPPPPLQHVPHEHYNQ-PHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSN 291
Query: 64 VLNRPVL-RGEDGDKAAPPPMSA------QLPGIPMPPPPLGLPPLQP--PPPPPPPPPG 114
++ P+ G + PPP A + G P+ P + P Q PPPPPPPP
Sbjct: 292 LITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPP- 350
Query: 115 LGLGFPMAHPP----------NLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERA 164
+ PM HPP + PPPP+ P + +AQ M
Sbjct: 351 --ISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI-IAQMPP--YMNHPPPG 405
Query: 165 KQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVA 224
H G PV PP P+
Sbjct: 406 PPPPQHG----------------------------GPPVTAPPPH----HYNPNSLPQFT 433
Query: 225 APVGPVGPTPTVLPMGAPV---PRPRGPPPPPGDENREMDDPSVGPKIP 270
G + P P P G P PRGPPPPP + P GP P
Sbjct: 434 EDQGTLSP-PFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHP 481
Score = 30.8 bits (68), Expect = 5.9
Identities = 40/164 (24%), Positives = 50/164 (30%), Gaps = 51/164 (31%)
Query: 5 HPEPPKAELQLPPPPPP-------------GHYGAWAAQELQAKLAEIGAPIQGNREELV 51
H PP+ PPPPPP G +Q + PI ++
Sbjct: 333 HIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHII 392
Query: 52 ERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPP----PLGLPP------ 101
++ Y +N P PPP P + PPP P LP
Sbjct: 393 AQMPPY-------MNHP--------PPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQG 437
Query: 102 -LQPP------------PPPPPPPPGLGLGFPMAHPPNLGPPPP 132
L PP P P PPP L P + P GP P
Sbjct: 438 TLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHP 481
>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
Length = 639
Score = 63.2 bits (152), Expect = 1e-09
Identities = 66/195 (33%), Positives = 75/195 (38%), Gaps = 49/195 (25%)
Query: 80 PPPMSAQLPGIP--------------MPPPPLGLPPLQPPPPPP---PPPPGLGLGFPMA 122
PPPM L P MPPPP+G+ P PPPPPP PPPP G P
Sbjct: 444 PPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMP--PPPPPPSGQPPPPPSGPLPPWQ 501
Query: 123 HPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQK 182
PPPP P + S L QQ G S+ +QQ+
Sbjct: 502 QQQQQPPPPP-----PPSSSMASSTPLPWQQ-----NTTTTTTSAGTGSIPP---WQQQQ 548
Query: 183 RAAVLLEQERQQEIAKMGTP--VPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG 240
AA Q + G P VP PP GV+ PL P A P P P + M
Sbjct: 549 AAAAASPGAPQMQ----GNPTMVPLPP------GVQPPLPPG-APPPPPPPPPGSAGMMY 597
Query: 241 APVPRPRGPPPPPGD 255
AP P PPPPP D
Sbjct: 598 APPP----PPPPPMD 608
Score = 61.2 bits (147), Expect = 4e-09
Identities = 42/128 (32%), Positives = 51/128 (39%), Gaps = 2/128 (1%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVL 65
P PP PPPPP G W Q+ Q + + L + + T T
Sbjct: 479 PPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGT 538
Query: 66 NRPVLRGEDGDKAAPPPMSAQLPGIP--MPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAH 123
+ AA P + Q+ G P +P PP PPL P PPPPPPP G M
Sbjct: 539 GSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYA 598
Query: 124 PPNLGPPP 131
PP PPP
Sbjct: 599 PPPPPPPP 606
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/140 (32%), Positives = 57/140 (40%), Gaps = 15/140 (10%)
Query: 6 PEPPKAELQLPPPPPPGH--------YGAWAAQELQAKLAEIGAPIQGNREELVERLQSY 57
P PP + PPPPP G W Q+ Q + + L + +
Sbjct: 471 PPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTT 530
Query: 58 TRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIP--MPPPPLGLPPLQP--PPPPPPPPP 113
T T + AA P + Q+ G P +P PP PPL P PPPPPPPPP
Sbjct: 531 TTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPP 590
Query: 114 GLGLGFPMAHPPNLGPPPPL 133
G G A PP PPPP+
Sbjct: 591 G-SAGMMYAPPP--PPPPPM 607
Score = 48.1 bits (113), Expect = 4e-05
Identities = 57/198 (28%), Positives = 70/198 (35%), Gaps = 38/198 (19%)
Query: 80 PPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPP--------PPGLGL-----GFPMAHPPN 126
PPP P + PPPP+ P P PPP P G G+ G M PP
Sbjct: 420 PPP-----PWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPP 474
Query: 127 LG---PPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKR 183
+G PPPP G+P L QQQ QQ+ S+ L Q+
Sbjct: 475 MGMMPPPPPPPSGQPPP-PPSGPLPPWQQQ-----QQQPPPPPPPSSSMASSTPLPWQQN 528
Query: 184 AAVL--------LEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPT 235
+ +QQ+ A + P PQ G PL P V P+ P P P
Sbjct: 529 TTTTTTSAGTGSIPPWQQQQAAAAAS--PGAPQMQGN-PTMVPLPPGVQPPLPPGAPPPP 585
Query: 236 VLPMGAPVPRPRGPPPPP 253
P PPPPP
Sbjct: 586 PPPPPGSAGMMYAPPPPP 603
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 62.4 bits (150), Expect = 2e-09
Identities = 61/187 (32%), Positives = 75/187 (40%), Gaps = 52/187 (27%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQEL-QAKLAEIGAPIQGNR--EELVERLQ-----SY 57
P+PP A +P PPP G +G A E +++ +G P R EEL L+ S
Sbjct: 1324 PQPP-ATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLPSFSS 1382
Query: 58 TRQTGIVLNR---------------PVLRGE------DGDKAAP-------PPM----SA 85
+ + NR P L G DG AP PP+ SA
Sbjct: 1383 DEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSA 1442
Query: 86 QLPGIPMPP----------PPLGLPPLQPPPPPPPPPPGLGLGFPMAHP-PNLGPPPPLR 134
G P PP PP P QPPPPPPPP P L P+ P P+ PPPPL
Sbjct: 1443 NSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLP 1502
Query: 135 VGEPVAL 141
P A+
Sbjct: 1503 PPPPPAM 1509
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/102 (33%), Positives = 44/102 (43%), Gaps = 9/102 (8%)
Query: 80 PPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPV 139
PPP P +P PPP + P PPPPP PPPP + P PP P EP
Sbjct: 1472 PPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPA 1531
Query: 140 ALSEEE---------RLKLAQQQAALLMQQEERAKQQGDHSL 172
A S E+ L Q+ AA+ + +E A + G +
Sbjct: 1532 APSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGESGGEGI 1573
Score = 48.1 bits (113), Expect = 4e-05
Identities = 52/185 (28%), Positives = 66/185 (35%), Gaps = 28/185 (15%)
Query: 95 PPL---GL-PPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPP---LRVGEPVALSEEERL 147
PPL GL PPL PP PP P GL P + PPP +G + +E E L
Sbjct: 1296 PPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGL 1355
Query: 148 KLAQQQAALLMQQEER---------AKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAK 198
L + +E + + + D K +L E A L+
Sbjct: 1356 GLGCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKD 1415
Query: 199 MGTP----------VPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRG 248
TP VP PP G + P P+ P PT P P P+P
Sbjct: 1416 TSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPE--PPLLEEKPPPTPPPAPTPQPQPPP 1473
Query: 249 PPPPP 253
PPPPP
Sbjct: 1474 PPPPP 1478
Score = 47.0 bits (110), Expect = 8e-05
Identities = 52/205 (25%), Positives = 72/205 (35%), Gaps = 49/205 (23%)
Query: 77 KAAPPPMSAQLPGIPMPPPPLGLPP------LQPPPPPPPPPPGLGLGFPMAHPPNLGPP 130
K PP A L P PP +PP LQP PP P P HPP P
Sbjct: 1293 KRHPPLYQAGLT--PPLSPPKSVPPSVPARGLQPQPPATPAVP---------HPP---PS 1338
Query: 131 PPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQ 190
+G + +E E L L + +E + +L+ + +V +
Sbjct: 1339 GAFGLGGALEAAESEGLGLGCPSPCKRLDEELK------RNLETLPSFSSDEEDSVAKNR 1392
Query: 191 ERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGP------------------ 232
+ Q+ I+ + + PP G TP GP +A GP
Sbjct: 1393 DLQESISSAISALDDPPL-AGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPP 1451
Query: 233 ----TPTVLPMGAPVPRPRGPPPPP 253
P P AP P+P+ PPPPP
Sbjct: 1452 LLEEKPPPTPPPAPTPQPQPPPPPP 1476
Score = 39.7 bits (91), Expect = 0.013
Identities = 45/139 (32%), Positives = 53/139 (38%), Gaps = 40/139 (28%)
Query: 23 HYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQT--GIVLNRPVLRGEDGDKAAP 80
HYGA A E+GA +Q + QS T+ T G++L G D P
Sbjct: 748 HYGAGAK--------ELGAFLQKSPPPPPPTAQS-TQPTPHGLLLEAG---GPDLPLVLP 795
Query: 81 PPMSAQLPGI----PMPPPPLG------LPPL------QPPPPPPPPPPGLGLGF----- 119
PP LP + P P P L P QPPPPPPPPPP + L
Sbjct: 796 PPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLR 855
Query: 120 -----PMAHPPNLGPPPPL 133
P A P L P L
Sbjct: 856 SHGLEPAAPSPRLRPEESL 874
Score = 38.5 bits (88), Expect = 0.028
Identities = 91/427 (21%), Positives = 131/427 (30%), Gaps = 105/427 (24%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVL 65
PEPP E + PP PPP A Q + P Q +
Sbjct: 1448 PEPPLLEEKPPPTPPP-------APTPQPQPPPPPPPPQP-----------------ALP 1483
Query: 66 NRPVLRGEDGDKAAPPPMSAQLPGI---PMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMA 122
+ P L PPP+ P P PPPP PL PP P P P
Sbjct: 1484 SPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDT 1543
Query: 123 HPPNLGPPPPLRV-------------GEPVALSEEE---------RLKLAQQ-------- 152
P +L GE + +E LKLA Q
Sbjct: 1544 RPLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPI 1603
Query: 153 ---QAALLMQQEERAKQQGDHSLKEHELL--------EQQKRAAVLLEQERQQEIAKMGT 201
Q ALL + K L Q+ LE +++ ++
Sbjct: 1604 WRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCA 1663
Query: 202 PVP--RPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENRE 259
P RPP + + G + PV G + P P+ P PPP E E
Sbjct: 1664 RKPWHRPPVPVRRSG-------QAKNPVSAGGSS---------APPPKAPAPPPKPETPE 1707
Query: 260 ---------------MDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSL 304
M +P P+ P L + + KE + + E T R +
Sbjct: 1708 KTTSEKPPEQTPETAMPEPP-APEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTR 1766
Query: 305 GQSASETEEDTVSVSKKEKNRKRRNR---KKKKKPQRVRGVSSESSGDREKDSTRSRGSD 361
+ + T + S K + K + KK+KK + G ++ + G S+ S S
Sbjct: 1767 PERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSP 1826
Query: 362 SPAADVE 368
++ E
Sbjct: 1827 GAPSEDE 1833
Score = 38.1 bits (87), Expect = 0.037
Identities = 74/291 (25%), Positives = 93/291 (31%), Gaps = 76/291 (26%)
Query: 9 PKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRP 68
P L LPPPPP Q L + L+ +P + V L+ TR
Sbjct: 788 PDLPLVLPPPPP---------QLLPSVLSHAPSPSPSASKVGVHLLEPATR--------- 829
Query: 69 VLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPP------LQPPPPPPPPPPGLGLGFPMA 122
DG PPP P P PP PL L L+P P P P L P A
Sbjct: 830 -----DGAPQPPPP-----PPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGA 879
Query: 123 HPPNLG-----PPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHEL 177
LG PP P G SE + A + + + R + L
Sbjct: 880 MQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPD-SL 938
Query: 178 LEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMG--QIGVRTPLGPRVAAPVGPVGP--- 232
L+ ++R+ +E A PP+D G + G P GP P GP P
Sbjct: 939 LQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRA 998
Query: 233 ----------------------TPTVLPMG---------APVPRPRGPPPP 252
T P+G AP P P PPPP
Sbjct: 999 SGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPP 1049
Score = 37.7 bits (86), Expect = 0.048
Identities = 45/182 (24%), Positives = 64/182 (35%), Gaps = 25/182 (13%)
Query: 76 DKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRV 135
D PP + + + P+ G PPPPPPPPP PP P +
Sbjct: 1011 DPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPP-----------PPAPASEPKGGL 1059
Query: 136 GEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQE 195
P+ S + + L LL +++ + +E+E + +A V +
Sbjct: 1060 TSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQEYEFEADEDKADV------PAD 1113
Query: 196 IAKMGTPVPRPPQDMGQIGVRTPLG-----PRVAAPVGP--VGPTPTVLPMGAPVPRPRG 248
I +P +PLG P P GP G PT P PRPRG
Sbjct: 1114 IRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPDGPRRRGRKPTKAKRDGP-PRPRG 1172
Query: 249 PP 250
P
Sbjct: 1173 RP 1174
Score = 34.7 bits (78), Expect = 0.41
Identities = 40/136 (29%), Positives = 54/136 (39%), Gaps = 23/136 (16%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEI-GAPIQG---NREELVERLQSYTRQT 61
P+PP PPPP +++ +LQ +L + G P G + + L S + T
Sbjct: 480 PQPPSG----PPPPGLATCQSYSPDQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSYST 535
Query: 62 GIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPP---PP----PPPPG 114
G + P L G G + L G P + PLQ PP PP P PG
Sbjct: 536 G---HSPALSGHGGGWGP-----SSLGGGGEASPSHIIRPLQSPPATGRPPGVGSPGAPG 587
Query: 115 LGLGFPMAHPPNLGPP 130
L +A P L PP
Sbjct: 588 KYLSSVLASAPFLAPP 603
Score = 32.3 bits (72), Expect = 2.0
Identities = 41/143 (28%), Positives = 49/143 (34%), Gaps = 42/143 (29%)
Query: 6 PEPPKAELQLPPPPP---PGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTG 62
P PP PPPPP P + A+ A AE +P +L +++
Sbjct: 229 PGPPD-----PPPPPRHLPTQFNLLASSSAAAAAAEQSSP----------QLYNFS---- 269
Query: 63 IVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPP-LQPPPPPPPPPP-----GLG 116
G PPP LP P QPPPPPPP G
Sbjct: 270 ------------GAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCG 317
Query: 117 LGFP-MAHPPNLGPPPPLRVGEP 138
+P M H NL PL GEP
Sbjct: 318 GSYPSMGHRANLA-CSPLGGGEP 339
Score = 31.6 bits (70), Expect = 3.4
Identities = 11/18 (61%), Positives = 12/18 (66%)
Query: 96 PLGLPPLQPPPPPPPPPP 113
P PP +P PP PPPPP
Sbjct: 221 PAQTPPYRPGPPDPPPPP 238
Score = 31.2 bits (69), Expect = 4.5
Identities = 27/77 (35%), Positives = 29/77 (37%), Gaps = 15/77 (19%)
Query: 75 GDKAAPPPMSAQLPGIPMPPPPLGLPPLQP-------PPPPPPPPPGLGL----GFPMAH 123
G + P P S L P PP GL L P P P P LG G +
Sbjct: 158 GSRPFPVPSSLSLQDPPFSPPANGL--LSPHDVLHLKPSQAPTVPSSLGFERLAGGGVLG 215
Query: 124 PPNLGP--PPPLRVGEP 138
P LGP PP R G P
Sbjct: 216 PAGLGPAQTPPYRPGPP 232
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 61.6 bits (148), Expect = 3e-09
Identities = 95/417 (22%), Positives = 146/417 (35%), Gaps = 67/417 (16%)
Query: 94 PPPLGLPPLQPPPPPPPPPP------GLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERL 147
PPP PP QPPPPPPPPPP L LG+P P L PP P P
Sbjct: 594 PPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPP 653
Query: 148 KLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQE---IAKMGTP-- 202
L + Q G + + Q + L Q RQ + A G P
Sbjct: 654 PHIYDFVNSLELMDRLGAQWGGMPMS----FQMQTQMLTRLHQLRQGKGLIAASAGPPGG 709
Query: 203 ------VPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPM---GAPVP-------RP 246
+P PP G+ L + G LPM P+P
Sbjct: 710 AFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEA 769
Query: 247 RGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQ 306
R PP + P+ G + + L ++Q +S + +++ E + A +
Sbjct: 770 RLPPREEAELAEGKTLPTAG-TVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWE 828
Query: 307 SASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAA- 365
S E + + +K++ + + + K K+P + V SG + GS A
Sbjct: 829 SKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGAL 888
Query: 366 --------DVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKE---------KEPE 408
E ++E E P + A + DD ++EKE K P+
Sbjct: 889 RLPSFKVKRKEPSEISEASEEKRP-----RPSTPAEEDEDDPEQEKEAGEPGRPGTKPPK 943
Query: 409 KLDKLENSAAPKKKGF------------EEEHKDSDDDSSDDEQEKKPEAPKLSKKK 453
+ ++ + +K F KD +DD D+E E + EA +KK+
Sbjct: 944 RDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKE 1000
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/214 (25%), Positives = 74/214 (34%), Gaps = 43/214 (20%)
Query: 80 PPPMSAQLPGIPMPPPPLGL-PPLQPPPPPPPPPPGLGLG----FPMAHPPNLGPPP--P 132
PP ++ LP P P PP PPP PP PG G G P P P P
Sbjct: 406 PPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASP 465
Query: 133 LRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQER 192
R G P + E + AQ + + +Q+ S + E+++ ++++L
Sbjct: 466 ARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARD 525
Query: 193 QQEIAKMG------TPVPRPP--QDMGQIGVRTP---------LGPRVAAPVG------- 228
G TP P P +D+ G P G A+P
Sbjct: 526 TGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEI 585
Query: 229 ---------PVGPTPTVLPMGAPVPRPRGPPPPP 253
P PTP P P P P PPPPP
Sbjct: 586 SDDDRGGSPPPAPTP---PQQPPPPPPPPPPPPP 616
Score = 49.7 bits (117), Expect = 1e-05
Identities = 90/360 (25%), Positives = 120/360 (33%), Gaps = 58/360 (16%)
Query: 4 EHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGI 63
E E P A PPP A E+ G+P+ L E+ S R G
Sbjct: 1066 EEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVT----PLPEQEASPARPAGP 1121
Query: 64 VLNRPV---LRGED--GDKAAPPPMSAQLPGIPMP--PPP------LGLPPLQPPPPPPP 110
P LR + AP P + P P+P PPP + ++ P P P
Sbjct: 1122 TEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEP 1181
Query: 111 PPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEE------RA 164
PP A PP P P P + R L A+L+ E R+
Sbjct: 1182 PP---------ATPPQAKFPGPASRKAPRGVERTIR-NLPLDHASLVKSWPEEVSRGGRS 1231
Query: 165 KQQGDHSLKEHE----------------LLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQ 208
+ G L E E L +R L E + RP
Sbjct: 1232 RAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRP 1291
Query: 209 DMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPK 268
+ I L A V P P P + P PVP P P DE E + V
Sbjct: 1292 LLSHI----LLEHNYALAVKPTPPAPALRPP-EPVPAPAALFSSPADEVLEAPEVVVAEA 1346
Query: 269 IPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRR 328
+++ Q +E +EE + EEEE E SS S+S+ E S + R+RR
Sbjct: 1347 EEPKPQQLQQQREEGEEEGEEEGEEEEEE----SSDSSSSSDGEGALRRRSLRSHARRRR 1402
Score = 40.4 bits (93), Expect = 0.007
Identities = 84/412 (20%), Positives = 140/412 (33%), Gaps = 66/412 (16%)
Query: 8 PPKAELQLPPPPPPGHYGAWAAQELQAKLAEI--GAPIQGNRE-ELVERLQSYTRQTGIV 64
PP E PPPPPP Y + EL +L G P+ + +++ RL + G++
Sbjct: 641 PPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLI 700
Query: 65 LNRPVLRGEDGDKAAPPPMSAQLPGIPMPPP---PLGLP--------------------- 100
A PP + +P PPP GLP
Sbjct: 701 ----------AASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHL 750
Query: 101 --PLQPPPPPPPPPPGLGLGFPMAHPPNLGP----PPPLRVGEPVALSEEERLKLAQQQA 154
P+ P P G P L P VG +A+ +E + Q+
Sbjct: 751 PMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDL 810
Query: 155 ALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIG 214
M + + E + + AA +E +E K+ P D + G
Sbjct: 811 NRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSG 870
Query: 215 VRTPL-------GPRVAAPVGPV---GPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPS 264
T + G R A + P+ + + RPR P DE+ +
Sbjct: 871 GTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKE 930
Query: 265 VG-PKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEK 323
G P P K + E R + ++ ++++ + +S+SE +E+ ++++
Sbjct: 931 AGEPGRPGT--KPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDE 988
Query: 324 NRKRRNRKKKKKPQRVRGVSSES----------SGDREKDSTRSRGSDSPAA 365
+R+ KK+ + G ES D E DST S S ++
Sbjct: 989 DREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSS 1040
Score = 32.3 bits (72), Expect = 2.0
Identities = 38/133 (28%), Positives = 51/133 (38%), Gaps = 11/133 (8%)
Query: 613 LRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWG- 671
LR +L +P K P A + P PS P + + PE G G
Sbjct: 884 LRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEE----DEDDPEQEKEAGEPGRPGT 939
Query: 672 KPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDK 731
KPP + + G G + F +E EE + E DEE EE+EE+E E+
Sbjct: 940 KPPKRDEER---GKTQGKHRKSFALDSEGEEASQESSSE---KDEEDDEEDEEDEDREEA 993
Query: 732 PDETGFITPADSG 744
D T T G
Sbjct: 994 VDTTKKETEVSDG 1006
Score = 32.0 bits (71), Expect = 2.6
Identities = 10/11 (90%), Positives = 11/11 (100%)
Query: 103 QPPPPPPPPPP 113
+PPPPPPPPPP
Sbjct: 1402 RPPPPPPPPPP 1412
>gi|40807447 papillary renal cell carcinoma translocation-associated
gene product isoform 1 [Homo sapiens]
Length = 491
Score = 61.6 bits (148), Expect = 3e-09
Identities = 41/122 (33%), Positives = 55/122 (45%), Gaps = 22/122 (18%)
Query: 75 GDKAAPPPMSAQLPGIPMP---PPPLGLPPLQPPPPPP------PPPP------------ 113
G PPP P P P PPP G P LQPPPP P PPPP
Sbjct: 47 GPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGE 106
Query: 114 GLGLGFPMAHPPNLGPPPPL-RVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSL 172
GLGLG P P L PPP+ G P+ L + ++ K + AA + + + ++ + +
Sbjct: 107 GLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSEEDEPTK 166
Query: 173 KE 174
K+
Sbjct: 167 KK 168
>gi|40807450 papillary renal cell carcinoma translocation-associated
gene product isoform 2 [Homo sapiens]
Length = 459
Score = 61.6 bits (148), Expect = 3e-09
Identities = 41/122 (33%), Positives = 55/122 (45%), Gaps = 22/122 (18%)
Query: 75 GDKAAPPPMSAQLPGIPMP---PPPLGLPPLQPPPPPP------PPPP------------ 113
G PPP P P P PPP G P LQPPPP P PPPP
Sbjct: 47 GPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGE 106
Query: 114 GLGLGFPMAHPPNLGPPPPL-RVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSL 172
GLGLG P P L PPP+ G P+ L + ++ K + AA + + + ++ + +
Sbjct: 107 GLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSEEDEPTK 166
Query: 173 KE 174
K+
Sbjct: 167 KK 168
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 61.2 bits (147), Expect = 4e-09
Identities = 35/78 (44%), Positives = 37/78 (47%), Gaps = 13/78 (16%)
Query: 68 PVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPP----PPPPPPPPGL-------- 115
P L G + PPM G P+PPPP PPL PP PPPPPPPP L
Sbjct: 656 PPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPN 715
Query: 116 -GLGFPMAHPPNLGPPPP 132
G P PP L PPPP
Sbjct: 716 PGGPPPAPPPPGLAPPPP 733
Score = 52.0 bits (123), Expect = 2e-06
Identities = 28/58 (48%), Positives = 30/58 (51%), Gaps = 9/58 (15%)
Query: 80 PPPMSAQL----PGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPL 133
PPP+ + L P PMPP G P PPPPPPP PP G PP PPPPL
Sbjct: 655 PPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAG-----PPPPPPPPPL 707
Score = 48.5 bits (114), Expect = 3e-05
Identities = 26/49 (53%), Positives = 27/49 (55%), Gaps = 3/49 (6%)
Query: 80 PPPMSAQLPGIPMPPPPLGLPPLQPPPPP-PPPPPGL--GLGFPMAHPP 125
PPP LP P PP P G PP PPP PPPPPGL GLG + P
Sbjct: 700 PPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCP 748
Score = 47.0 bits (110), Expect = 8e-05
Identities = 30/63 (47%), Positives = 32/63 (50%), Gaps = 11/63 (17%)
Query: 77 KAAPPPMSAQLPGIPMPPP-PLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNL------GP 129
KA PPP ++ IP PPP P GL L P PP PP G L P PP L GP
Sbjct: 643 KALPPPPAS----IPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGP 698
Query: 130 PPP 132
PPP
Sbjct: 699 PPP 701
Score = 40.0 bits (92), Expect = 0.010
Identities = 20/66 (30%), Positives = 27/66 (40%)
Query: 188 LEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPR 247
+ +Q+ + +P PP +G +P P GP P P P P P
Sbjct: 637 MASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSA 696
Query: 248 GPPPPP 253
GPPPPP
Sbjct: 697 GPPPPP 702
Score = 37.4 bits (85), Expect = 0.063
Identities = 22/70 (31%), Positives = 29/70 (41%), Gaps = 1/70 (1%)
Query: 202 PVPRPPQDMGQIGVRTPLGPRVAAP-VGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREM 260
P P P +G + P+ P A P + P P P LP + P PPPPP +
Sbjct: 654 PPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAP 713
Query: 261 DDPSVGPKIP 270
+P P P
Sbjct: 714 PNPGGPPPAP 723
Score = 33.5 bits (75), Expect = 0.91
Identities = 24/82 (29%), Positives = 28/82 (34%), Gaps = 14/82 (17%)
Query: 199 MGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVG-------PTPTVLPMGAPVPRPRGPPP 251
+G+ P PP G P P P+ P P P LP P P GPPP
Sbjct: 662 LGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPP 721
Query: 252 PPGDENREMDDPSVGPKIPQAL 273
P P + P P L
Sbjct: 722 AP-------PPPGLAPPPPPGL 736
Score = 33.5 bits (75), Expect = 0.91
Identities = 56/255 (21%), Positives = 94/255 (36%), Gaps = 45/255 (17%)
Query: 615 ISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGG--WGK 672
+S G P+ P PPP L GPPP P +P NSP P + GG
Sbjct: 674 VSAGPPLPPPPP--PPPPLPPPSSAGPPPPPPPPPLP--NSPAPP------NPGGPPPAP 723
Query: 673 PPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTP-----WGELEPSDEESSEE----EE 723
PP P G FG ++ Q + P W ++ SD + +
Sbjct: 724 PPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDS 783
Query: 724 EEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMD-GSETPQ 782
EE D P E ++ D+ + +KK + E + ++ +
Sbjct: 784 LEEPDIRDPSEFEYLFSKDT--------------------TQQKKKPLSETYEKKNKVKK 823
Query: 783 LFTVLPEKRTATVGGAMMGSTHI--YDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM 840
+ +L KR+ TV G ++ S H+ D+ + + AL + D +
Sbjct: 824 IIKLLDGKRSQTV-GILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVK 882
Query: 841 TQKYEEHVREQQAQV 855
+KY E +E++ ++
Sbjct: 883 IRKYYETSKEEELKL 897
Score = 33.1 bits (74), Expect = 1.2
Identities = 52/237 (21%), Positives = 87/237 (36%), Gaps = 33/237 (13%)
Query: 200 GTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRP-----RGPPPPPG 254
G P+P PP + + GP P P+ +P G P P P PPPPPG
Sbjct: 677 GPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLA-PPPPPG 735
Query: 255 -------DENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQS 307
++ P++ P P +++ S + + + + +E +
Sbjct: 736 LFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEF 795
Query: 308 ASETEEDTVSVSKK--EKNRKRRNRKKK-------KKPQRVRGVSSESSGDREKDSTRS- 357
+DT KK + +++N+ KK K+ Q V G+ S KD ++
Sbjct: 796 EYLFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDGKRSQTV-GILISSLHLEMKDIQQAI 854
Query: 358 RGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLE 414
D D+E E E + ++ +E KE+E + LDK E
Sbjct: 855 FNVDDSVVDLETLAALYENRAQEDELVKIRKYYET---------SKEEELKLLDKPE 902
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 61.2 bits (147), Expect = 4e-09
Identities = 79/293 (26%), Positives = 115/293 (39%), Gaps = 38/293 (12%)
Query: 68 PVLRGE-DGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPN 126
P RG +G A PP +A LPG +P P PPPPPPP L + PP
Sbjct: 558 PAARGSLEGPSA--PPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPP 615
Query: 127 LGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAV 186
PP PL P ++ +M GD+S ELL + K
Sbjct: 616 -APPLPLESAGPGCGQRRSSSSTGSTKSFNMM------SPTGDNS----ELLAEIKAGKS 664
Query: 187 LLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPV-GPTPTV-----LPMG 240
L + + + + + + +P +PL P V+ + PV PTP L G
Sbjct: 665 LKPTPQSKGLTTVFSGIGQP-----AFQPDSPL-PSVSPALSPVRSPTPPAAGFQPLLNG 718
Query: 241 APVPRPRGPPPPPGDENREMDDPS---VGPKIP----QALEKILQLKESRQEEMNSQQEE 293
+ VP P P P + E P+ G IP Q + + +QLK +EE ++EE
Sbjct: 719 SLVPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEE 778
Query: 294 EE-----METDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRG 341
EE M R L + E E +++K + R K++ + R G
Sbjct: 779 EEARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELRREKEQSEKLRTLG 831
Score = 49.3 bits (116), Expect = 2e-05
Identities = 64/229 (27%), Positives = 76/229 (33%), Gaps = 27/229 (11%)
Query: 54 LQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLG--LPPLQPPPPPPPP 111
+QSY L P RG G PPP P P PPPP G LPP PPP P P
Sbjct: 407 IQSYMDMLNPELGLP--RGTIGKPTPPPPP----PSFPPPPPPPGTQLPP--PPPGYPAP 458
Query: 112 PPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHS 171
P +G P A + LR E AL +E L L Q R +
Sbjct: 459 KPPVG---PQAADIYMQTKNKLRHVETEALKKE--LSSCDGHDGLRRQDSSRKPRAFSKQ 513
Query: 172 LKEHELLEQQKR----------AAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGP 221
+ Q R E+ R ++ A+ G P P G P P
Sbjct: 514 PSTGDYYRQLGRCPGETLAARPGMAHSEEVRARQPARAGCPRLGPAARGSLEGPSAP--P 571
Query: 222 RVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIP 270
+ A G P A P PPPPP P P +P
Sbjct: 572 QAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLP 620
Score = 35.8 bits (81), Expect = 0.18
Identities = 47/221 (21%), Positives = 84/221 (38%), Gaps = 31/221 (14%)
Query: 6 PEPPKAELQLPPPPPP----GHYGAWAAQELQA------KLAEIGAPIQGNREELVE--- 52
P PP E PPP P G Q + K + +P N E L E
Sbjct: 602 PPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKA 661
Query: 53 --RLQSYTRQTGIV-----LNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPL--- 102
L+ + G+ + +P + + + P +S P PP G PL
Sbjct: 662 GKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALS---PVRSPTPPAAGFQPLLNG 718
Query: 103 -QPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQE 161
P PP P PG+ L P + P+ + + + +LK+ +++ ++E
Sbjct: 719 SLVPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEE 778
Query: 162 ERAKQQG----DHSLKEHELLEQQKRAAVLLEQERQQEIAK 198
E A+ L +L E++++ E+++Q+E+ +
Sbjct: 779 EEARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELRR 819
Score = 31.6 bits (70), Expect = 3.4
Identities = 26/97 (26%), Positives = 36/97 (37%), Gaps = 13/97 (13%)
Query: 219 LGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVG------PKIPQA 272
L P + P G +G PT P P P PPPP ++ P G P PQA
Sbjct: 414 LNPELGLPRGTIGK-PT------PPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQA 466
Query: 273 LEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSAS 309
+ +Q K + ++E D L + S
Sbjct: 467 ADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDS 503
Score = 30.4 bits (67), Expect = 7.7
Identities = 26/74 (35%), Positives = 29/74 (39%), Gaps = 16/74 (21%)
Query: 611 DELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSY-PNLKIPGLNSPIPESCSFGYHAGG 669
D L LG+P G PPP PPPS+ P PG P P GY A
Sbjct: 412 DMLNPELGLPRGTIGKPTPPP---------PPPSFPPPPPPPGTQLPPPPP---GYPA-- 457
Query: 670 WGKPPVDETGKPLY 683
KPPV +Y
Sbjct: 458 -PKPPVGPQAADIY 470
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 60.8 bits (146), Expect = 5e-09
Identities = 99/466 (21%), Positives = 188/466 (40%), Gaps = 59/466 (12%)
Query: 143 EEERLKLAQQQAALLMQQEERAKQQGDHSLKEH------ELLEQQKRAAVLLEQERQQEI 196
E + L Q++A + EE+ K++ +E ++ E QK + E+E +++
Sbjct: 197 ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKA 256
Query: 197 AKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDE 256
A V + Q R + V + P G +P + P P+P + P P
Sbjct: 257 A-----VSKHEQKDQYAFCRYMIDIFVHGDLKP-GQSPAIPP---PLPTEQASRPTPASP 307
Query: 257 NREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTV 316
E + G K +A +K+ + +++E ++ E+E D ASET++ TV
Sbjct: 308 ALEEKE---GEK-KKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTV 363
Query: 317 SVSKK---EKNRKRRNRKKKKKPQRV---RGVSSESSGDREKDSTRSRGSDSPAADVEIE 370
++ + +K+ K+ + KK KKP V +G E + + + S +D +++
Sbjct: 364 KIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVK 423
Query: 371 YVTEEPEIYEPNFIFFKRIFEAFK-------LTDDVKKE---------KEKEPEKLDKLE 414
TE + E + K+ K + +++KE K+KEP K + +
Sbjct: 424 AKTERAK-EEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEK 482
Query: 415 NSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDV 474
A+ K+K E D+ S +E KP+ P+L KK + E K ++
Sbjct: 483 VPASLKEK---EPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQ 539
Query: 475 VEMHDVT---------AQDPKLLVHLKA-----TRNSVPVPRHWCFKRKYLQGKRGIEKP 520
+ D+ + K+L +KA T P + +R+ K KP
Sbjct: 540 IHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKP 599
Query: 521 PFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDI 566
+ + +G ++ + +E +E+ MK EKV + + +
Sbjct: 600 TPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQL 645
Score = 46.2 bits (108), Expect = 1e-04
Identities = 113/575 (19%), Positives = 207/575 (36%), Gaps = 118/575 (20%)
Query: 283 RQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRK----KKKKPQ- 337
R++E++ + E++ + + + + E E+ V +KEK K+ K KK+KP+
Sbjct: 139 RKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPET 198
Query: 338 ----------RVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYE------- 380
+ S E + K + + + A E++ +P+ E
Sbjct: 199 KTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV 258
Query: 381 ------PNFIFFKRIFEAFKLTDDVK--------------------------KEKEKEPE 408
+ F + + + F + D+K +EKE E +
Sbjct: 259 SKHEQKDQYAFCRYMIDIF-VHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKK 317
Query: 409 KLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVA----- 463
K +K S KKK E+ K S+ +++ D ++K+P +K+ ++ A
Sbjct: 318 KAEKKVTSET-KKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK 376
Query: 464 -ELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPF 522
E + +P VE Q+ K H++ ++ P H K ++ K K
Sbjct: 377 KEDSKKTKKPAEVEQPKGKKQEKK-EKHVEPAKS--PKKEHSVPSDKQVKAKTERAK--- 430
Query: 523 ELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKP 582
+ G +++A+ K+E+KT K+ +E + K GK K
Sbjct: 431 ------EEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSS------------ILKD 472
Query: 583 KLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPP 642
K I G + ++ LKEK+P DE G V P PP L + P
Sbjct: 473 KEPIKG----KEEKVPASLKEKEPETKKDEKMSKAGKEVKPK-----PPQLQGKKEEKPE 523
Query: 643 PSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDET-GKPLYGDVFGTNAAEFQTKTEEE 701
P P ++ + H KP + GKP E + + +
Sbjct: 524 PQIKKEAKPAISEKVQ------IHKQDIVKPEKTVSHGKP-----------EEKVLKQVK 566
Query: 702 EIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVP-AGMET 760
+ + +P+ + E E DKP TP + +T G + E+
Sbjct: 567 AVTIEKTAKPKPTKKAEHREREPPSIKTDKPKP----TPKGTSEVTESGKKKTEISEKES 622
Query: 761 PELIELRKKKIEEAMDGSETPQLFTVLPEKRTATV 795
E +++ + E+ E+ QL V ++ A V
Sbjct: 623 KEKADMKHLREEKVSTRKESLQLHNVTKAEKPARV 657
Score = 32.3 bits (72), Expect = 2.0
Identities = 51/240 (21%), Positives = 101/240 (42%), Gaps = 55/240 (22%)
Query: 151 QQQAALLMQQEERAKQQGDHS--LKEHELLE--QQKRAAVLLEQE----RQQEIAKMGTP 202
+++ ++QE R ++ G S LK+ E ++ ++K A L E+E + ++++K G
Sbjct: 447 EEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKE 506
Query: 203 V-PRPPQDMG------QIGVRTPLGPRVAAPV-----GPVGPTPTVLPMGAP-------- 242
V P+PPQ G + ++ P ++ V V P TV G P
Sbjct: 507 VKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTV-SHGKPEEKVLKQV 565
Query: 243 ----VPRPRGPPPPPGDENREMDDPSV------------------GPKIPQALEKILQ-- 278
+ + P P E+RE + PS+ G K + EK +
Sbjct: 566 KAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEK 625
Query: 279 --LKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKP 336
+K R+E++++++E ++ ++ S+ ED + K ++ + + K+K P
Sbjct: 626 ADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSP 685
Score = 32.0 bits (71), Expect = 2.6
Identities = 60/283 (21%), Positives = 112/283 (39%), Gaps = 22/283 (7%)
Query: 342 VSSESSGDREKDSTRSRGS--DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDV 399
+SSE D + D +G + P EI E + I K + + +
Sbjct: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
Query: 400 KKEKEKEPEKL---DKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRR 456
+EKEK +K +K+E P+ K +E K + +++ +EK + K K++ +
Sbjct: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKA--KTAEKSEEKTKKEVKGGKQEKVK 231
Query: 457 MNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKA-TRNSVPVPRHWCFKRKYLQGKR 515
V E+++ ++P E + A A R + + H K G+
Sbjct: 232 QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLK----PGQS 287
Query: 516 GIEKPPFELPDFIKRTGIQ---EMREALQEKEEQKT---MKSKMREKVRPKMGK---IDI 566
PP + T E +E ++K E+K K K +E ++ K K ID+
Sbjct: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
Query: 567 DYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDL 609
+ ++ A Q K+ + K+ +++ K KKP ++
Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSK-KTKKPAEV 389
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 60.1 bits (144), Expect = 9e-09
Identities = 58/206 (28%), Positives = 77/206 (37%), Gaps = 37/206 (17%)
Query: 82 PMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVAL 141
P +A P P+PPPP PP PPPPPPPPP P P+ G P+ V
Sbjct: 618 PYTASQPSPPLPPPPPPPPPPPPPPPPPPPP------LPSQSAPSAGSAAPMF----VKY 667
Query: 142 SEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGT 201
S RL+ A Q + L + Q Q + +L+
Sbjct: 668 STITRLQNASQHSGALFKPPTPPVMQ-----------SQSVKPQILVPPNGVVPPPPPPP 716
Query: 202 PVPRPPQDMGQI--GVRTPLGPRVAAPVGPV------------GPT-PTVLPMGAPVPRP 246
P P P M Q+ P P+ +AP P+ PT P P+ AP+P P
Sbjct: 717 PPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLP-P 775
Query: 247 RGPPPPPGDENREMDDPSVGPKIPQA 272
+ PP P +V P + QA
Sbjct: 776 QAPPKPLVTIPAPTSTKTVAPVVTQA 801
Score = 56.6 bits (135), Expect = 1e-07
Identities = 44/142 (30%), Positives = 59/142 (41%), Gaps = 28/142 (19%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGN------REELVERLQSYTR 59
P PP PPPPPP L AP G+ + + RLQ+ ++
Sbjct: 624 PSPPLPPPPPPPPPPPP-----PPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQ 678
Query: 60 QTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLG- 118
+G + P PP M +Q + PP G+ P PPPPPPPP PG +
Sbjct: 679 HSGALFKPP----------TPPVMQSQSVKPQILVPPNGVVP-PPPPPPPPPTPGSAMAQ 727
Query: 119 -FPMAHPPNL----GPPPPLRV 135
P P+L PPPPL++
Sbjct: 728 LKPAPCAPSLPQFSAPPPPLKI 749
Score = 55.8 bits (133), Expect = 2e-07
Identities = 70/270 (25%), Positives = 86/270 (31%), Gaps = 76/270 (28%)
Query: 8 PPKAELQLPPPPPPGHYGAWAAQELQA-----KLAEIGAPIQGNREELVERLQSYTRQTG 62
PP + PPPPPP A +L+ L + AP + V+ + T
Sbjct: 704 PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPT- 762
Query: 63 IVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPP--------------LQPPPPP 108
PPP+ A LP P P + +P P P P
Sbjct: 763 --------------PPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTP 808
Query: 109 PPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQG 168
P PP FP ++ P P PP+ V P L QQ AK
Sbjct: 809 PVPPAKKQPAFPASYIPPSPPTPPVPVPPP----------------TLPKQQSFCAKPPP 852
Query: 169 DHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVG 228
+++Q IA P P PP Q PL P V A V
Sbjct: 853 SPLSPVPSVVKQ---------------IASQFPPPPTPPAMESQ-----PLKP-VPANVA 891
Query: 229 PVGP-----TPTVLPMGAPVPRPRGPPPPP 253
P P P P PVP P PPPPP
Sbjct: 892 PQSPPAVKAKPKWQPSSIPVPSPDFPPPPP 921
Score = 42.0 bits (97), Expect = 0.003
Identities = 69/277 (24%), Positives = 89/277 (32%), Gaps = 60/277 (21%)
Query: 6 PEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVL 65
P PP LPP PP L I AP T
Sbjct: 764 PPPPPIPAPLPPQAPP------------KPLVTIPAP------------------TSTKT 793
Query: 66 NRPVLRGEDGDKAAPPPMSAQLPGIPMPP--PPLGLPPLQPPPPPPPPPPGLGLGFPMAH 123
PV+ +AAPP + +P P P +PP P PP P PPP L
Sbjct: 794 VAPVV-----TQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCA 848
Query: 124 PPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKR 183
P PP PL PV + +Q A+ + + Q
Sbjct: 849 KP---PPSPL---SPVP-------SVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSP 895
Query: 184 AAVLLEQERQQEIAKMGTP-VPRPPQDMGQIGVRTPLGPRVAAPVGPVGPT--PTVLPMG 240
AV + + Q + +P P PP + + P P V AP P PT PT G
Sbjct: 896 PAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSP-VPAPPPPPPPTASPTPDKSG 954
Query: 241 AP------VPRPRGPPPPPGDENREMDDPSVGPKIPQ 271
+P P G PPP + S G + P+
Sbjct: 955 SPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPE 991
Score = 36.6 bits (83), Expect = 0.11
Identities = 17/50 (34%), Positives = 21/50 (42%)
Query: 221 PRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIP 270
P++ P P+P + P P P P PPPPP PS G P
Sbjct: 613 PKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAP 662
Score = 34.3 bits (77), Expect = 0.53
Identities = 30/106 (28%), Positives = 39/106 (36%), Gaps = 7/106 (6%)
Query: 4 EHPEP--PKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQT 61
EHPEP P + + PP G+ + + L A P G L +Q
Sbjct: 988 EHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP---PKPGKLNLSGVNLPGVLQQG 1044
Query: 62 GIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPP--PLGLPPLQPP 105
+ PVL G D P P PPP L LPP++ P
Sbjct: 1045 CVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIP 1090
>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
Length = 2157
Score = 59.7 bits (143), Expect = 1e-08
Identities = 79/281 (28%), Positives = 102/281 (36%), Gaps = 69/281 (24%)
Query: 2 ATEHPEPPKA---ELQLPPPPPPGHYGAWAAQELQAKLAEIGAPI-QGNREELVERLQSY 57
A P PP A EL PP PPP AP + EE + +
Sbjct: 514 APSTPAPPPAVPKELPAPPAPPPA-----------------SAPTPETEPEEPAQAPPAQ 556
Query: 58 TRQTGIVLNRPVLRGEDGDKAAPP-------PMSAQLPGIPMPPPPLGLPPLQPPPPPPP 110
+ T V P L G ++ P+ QLP P PP +PP PP P
Sbjct: 557 STPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKV 616
Query: 111 PPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDH 170
P G G+G P PP+ G +G P ++ L Q+ QQE+ KQQ H
Sbjct: 617 EPKGDGIG-PTRQPPSQG------LGYP---KYQKSLPPRFQR----QQQEQLLKQQQQH 662
Query: 171 SLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPV 230
++H Q+ + TPVP P +G V AP P
Sbjct: 663 QWQQH------------------QQGSAPPTPVPPSPPQPVTLGA-------VPAPQAP- 696
Query: 231 GPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQ 271
P P L GA + RP PP D M P V P++ Q
Sbjct: 697 PPPPKALYPGA-LGRPPPMPPMNFDPRWMMIPPYVDPRLLQ 736
Score = 56.6 bits (135), Expect = 1e-07
Identities = 53/204 (25%), Positives = 78/204 (38%), Gaps = 27/204 (13%)
Query: 71 RGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPP 130
+G + P P +A P G P +PP PPP P G P +P GPP
Sbjct: 377 KGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPP 436
Query: 131 --PPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLL 188
PP E A +R K + + +L +++ R +++ E +++++RAA
Sbjct: 437 CKPPAPEDEDEAW--RQRRKQSSSEISLAVERARRRREE------EERRMQEERRAACAE 488
Query: 189 EQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRG 248
+ +R E K G P R L AAP P P+ P P P
Sbjct: 489 KLKRLDE--KFGAPDKR-------------LKAEPAAP--PAAPSTPAPPPAVPKELPAP 531
Query: 249 PPPPPGDENREMDDPSVGPKIPQA 272
P PPP +P + P A
Sbjct: 532 PAPPPASAPTPETEPEEPAQAPPA 555
Score = 49.3 bits (116), Expect = 2e-05
Identities = 68/286 (23%), Positives = 101/286 (35%), Gaps = 42/286 (14%)
Query: 72 GEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPP-------PPPPPGLGLGFPMAHP 124
G D P Q P PP PP P PPP P P FP
Sbjct: 228 GHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAG 287
Query: 125 PNLGPPPPLRVGEPV---ALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQ 181
P G PP+R+ EPV ++ +E+ LK Q + QE G H +E + E+
Sbjct: 288 PR-GSGPPMRLVEPVGRPSILKEDNLKEFDQ-----LDQENDDGWAGAH--EEVDYTEKL 339
Query: 182 KRAAVLLEQERQQEIA------KMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPT 235
K + ++ +E A + + RPP+ G+ G P P
Sbjct: 340 KFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPP 399
Query: 236 VLPMGAPVPRPRGPPP---------PPGDENREMDDPSVGPKIPQALEKILQLKESRQEE 286
G P P+P PPP PPGD P P E Q ++ E
Sbjct: 400 ETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSE 459
Query: 287 MN---------SQQEEEEMETDARSSLGQSASETEEDTVSVSKKEK 323
++ ++EE M+ + R++ + +E + K+ K
Sbjct: 460 ISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLK 505
Score = 43.1 bits (100), Expect = 0.001
Identities = 73/304 (24%), Positives = 94/304 (30%), Gaps = 62/304 (20%)
Query: 6 PEPPKAELQLPPPP--------PPGHYG-----------------AWAAQELQAKLAEIG 40
P PP + LPPP PPG Y AW + Q+ +EI
Sbjct: 403 PGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSS-SEIS 461
Query: 41 APIQG---NREELVERLQSYTRQT-GIVLNRPVLRGEDGDKA--APPPMSAQLPGIPMPP 94
++ REE R+Q R L R + DK A P P P PP
Sbjct: 462 LAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPP 521
Query: 95 P--PLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQ 152
P P LP PPP P P P PP P P P +S
Sbjct: 522 PAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSS 581
Query: 153 QAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQ 212
+ E + + + E + V + + I P P Q +G
Sbjct: 582 GSFEASPVEPQLPSK--EGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQP---PSQGLGY 636
Query: 213 IGVRTPLGPRV-----------------------AAPVGPVGPTPTVLPMGAPVPRPRGP 249
+ L PR +AP PV P+P VP P+ P
Sbjct: 637 PKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAP 696
Query: 250 PPPP 253
PPPP
Sbjct: 697 PPPP 700
Score = 37.4 bits (85), Expect = 0.063
Identities = 38/132 (28%), Positives = 51/132 (38%), Gaps = 31/132 (23%)
Query: 17 PPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGD 76
PP P G A E +++ +E EE+ +R + +TG + L D
Sbjct: 1076 PPAPRGR----TASETRSEGSEY--------EEIPKRRRQRGSETGSETHESDLA--PSD 1121
Query: 77 KAAPPPMSAQLPGIPMPPPPLGLPPLQPP------------PPPPPPPPGLGLGFPMAHP 124
K AP P L +P+ PPP G PP P P P G G G P P
Sbjct: 1122 KEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRP---P 1178
Query: 125 PNLGP--PPPLR 134
P + P PP +
Sbjct: 1179 PQVCPGWSPPAK 1190
Score = 36.6 bits (83), Expect = 0.11
Identities = 19/52 (36%), Positives = 22/52 (42%)
Query: 81 PPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPP 132
P LP + P + L P PPP PPP L P PP+L PP
Sbjct: 1975 PAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPP 2026
Score = 35.8 bits (81), Expect = 0.18
Identities = 48/208 (23%), Positives = 67/208 (32%), Gaps = 54/208 (25%)
Query: 70 LRGEDGDKAAPPPMSAQLPGIP---MPPPPLGLPPLQPPPPPPPP-PPGLGLGFPMAHPP 125
+R E PPP A PG P P PP+ PL+ P P P P PPG + PP
Sbjct: 821 MRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPP 880
Query: 126 NLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAA 185
PP +EE +L +A R +G
Sbjct: 881 PKKEPP-----------KEETAQLTGPEAG-------RKPARG----------------- 905
Query: 186 VLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPR 245
+G+ PP + T GPR + + P P P
Sbjct: 906 -------------VGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPI 952
Query: 246 PRGPPPPPGDE--NREMDDPSVGPKIPQ 271
+ PPP +E + ++ PK P+
Sbjct: 953 KKPPPPTKVEELPPKPLEQGDETPKPPK 980
Score = 33.9 bits (76), Expect = 0.69
Identities = 48/151 (31%), Positives = 57/151 (37%), Gaps = 27/151 (17%)
Query: 6 PEPPK----AELQLPPP---PPPGHYGAWAAQELQAKLAE-IGAPIQG----NREELVER 53
P PP A++Q PPP PP E K A +G+ QG RE E
Sbjct: 865 PWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTET 924
Query: 54 L---QSYTRQTGIVLNRPVL--RGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPP 108
+ + + GI P R K PPP + +PP PL P PP
Sbjct: 925 RWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVE----ELPPKPLEQGDETPKPPK 980
Query: 109 PPP---PPGLGLGFPMAHPP--NLGPPPPLR 134
P P G LG P PP NL P P LR
Sbjct: 981 PDPLKITKG-KLGGPKETPPNGNLSPAPRLR 1010
Score = 33.1 bits (74), Expect = 1.2
Identities = 52/194 (26%), Positives = 69/194 (35%), Gaps = 46/194 (23%)
Query: 65 LNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHP 124
L P+ + D D M ++ P +P PPP L P P P PP FP+ P
Sbjct: 806 LTSPLRQAADEDDKG---MRSETPPVPPPPPYLASYPGFPENGAPGPPIS---RFPLEEP 859
Query: 125 -PNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKR 183
P P PP +E AK Q KE ++
Sbjct: 860 GPRPLPWPP--------------------------GSDEVAKIQTPPPKKE----PPKEE 889
Query: 184 AAVLLEQERQQEIAK-MGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAP 242
A L E ++ A+ +G+ PP + T GPR + + P GAP
Sbjct: 890 TAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEP----GAP 945
Query: 243 VPRPRGP---PPPP 253
PR GP PPPP
Sbjct: 946 -PRRAGPIKKPPPP 958
Score = 31.6 bits (70), Expect = 3.4
Identities = 20/55 (36%), Positives = 23/55 (41%), Gaps = 4/55 (7%)
Query: 79 APPPMSAQLPGIPMPPPPLGLPPLQPPP----PPPPPPPGLGLGFPMAHPPNLGP 129
APPP+S G + PP L + P P P P P LG HP L P
Sbjct: 2003 APPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPASLGRAELHPVELKP 2057
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 59.3 bits (142), Expect = 2e-08
Identities = 71/348 (20%), Positives = 156/348 (44%), Gaps = 44/348 (12%)
Query: 272 ALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRK 331
A + ++ ++ R E +N Q+E+EE+E + E + V K E+ R R+ K
Sbjct: 570 ARRQTIEERKERLESLNIQREKEELE------------QREAELQKVRKAEEERLRQEAK 617
Query: 332 KKKKP---QRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKR 388
+++K Q + ++ +R + ++ D++IE + E +P+FI K+
Sbjct: 618 EREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEE----LDPDFIMAKQ 673
Query: 389 IFEAFKLTDDVKKEKEKEPEKLDKLENS----AAPKKKGFEEEHKDSDDDSSDDEQEKKP 444
+ + K ++++ + + +K+D E + P K EE + D D + ++E++
Sbjct: 674 VEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERI 733
Query: 445 EAPKLSKKK-LRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRH 503
+L ++K L NR + ++E D+ ++ LKA R SV +
Sbjct: 734 TTMQLEREKALEHKNRMS-----------RMLEDRDL------FVMRLKAARQSVYEEKL 776
Query: 504 WCFKRKYLQGKRG-IEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMG 562
F+ + + + +E+ + + + T +E E Q + E++ +K + E+ R +
Sbjct: 777 KQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKER-EERERAERA 835
Query: 563 KIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLS 610
K + + ++ + K + + +L E +E R +E++ GD S
Sbjct: 836 KREEELREYQERVKKLEEVERKKRQRELEIEERE-RRREEERRLGDSS 882
Score = 31.2 bits (69), Expect = 4.5
Identities = 19/52 (36%), Positives = 33/52 (63%), Gaps = 4/52 (7%)
Query: 143 EEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQ 194
EEE + A++Q +L ++EER ++ + + +E EL E Q+R L E ER++
Sbjct: 811 EEEEQRRAEEQ--MLKEREER--ERAERAKREEELREYQERVKKLEEVERKK 858
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 59.3 bits (142), Expect = 2e-08
Identities = 87/387 (22%), Positives = 152/387 (39%), Gaps = 22/387 (5%)
Query: 255 DENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEED 314
DE EM++ A+ + KE+ +E+ + EEE +S + +A E +E+
Sbjct: 464 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 523
Query: 315 TVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREK-DSTRSRGSDSPAADVEIEYVT 373
++E + + K + SE G EK + + G A+ E
Sbjct: 524 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583
Query: 374 EEPEIYEPNFIFFKRIFEAFKLTDDVKKEK-EKEPEKLDKL---ENSAAPKKKGFEEEHK 429
EE ++ E + + + +L D K EK EK + K E +P K EE
Sbjct: 584 EEKKVEEKS----EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG 639
Query: 430 DSDDDSSDDEQEKKPEAPK--LSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKL 487
S S E++ K PK + +K +++ V E + VE A+ K
Sbjct: 640 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 699
Query: 488 LVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQ------ 541
+ + P+ ++K + K EK E P +K + E+ +
Sbjct: 700 EQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP--VKEEAVAEVVTITKSVKVHL 757
Query: 542 EKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGK-EFETR 600
EKE ++ K +EK + K G ++ D K K + ++G++ EGK E E
Sbjct: 758 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV--EGKEEVEQE 815
Query: 601 LKEKKPGDLSDELRISLGMPVGPNAHK 627
KEK G ++ ++ G+ + P K
Sbjct: 816 TKEKGSGREEEKGVVTNGLDLSPADEK 842
Score = 42.4 bits (98), Expect = 0.002
Identities = 65/349 (18%), Positives = 137/349 (39%), Gaps = 51/349 (14%)
Query: 161 EERAKQQGDHSLKEHELLEQQKRAAVLLEQE-----RQQEIAKMGTPVPRPP-QDMGQIG 214
E A+ +G+ + + E ++K V ++E + ++ K +PVP+ P ++ G+
Sbjct: 570 ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 629
Query: 215 V-RTPLGPRVAAPV----------GPVGPTPTVLPMGAPVPRP----RGPPPPPGDENRE 259
V ++P+ + +PV PV +P +PV + + P P E
Sbjct: 630 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 689
Query: 260 MDDPSVGPKIPQALEKILQLKES-RQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSV 318
+ K Q E+ ++KE+ ++E++ ++E+ + + + + E + V++
Sbjct: 690 AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI 749
Query: 319 SKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEI 378
+K K + K++ KP + ++ G+ + GSD A E + E+
Sbjct: 750 TKSVKVHLEKETKEEGKPLQQEKEKEKAGGE---GGSEEEGSDKGAKGSRKEDIAVNGEV 806
Query: 379 YEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKD---SDDDS 435
E ++E E+ K + S ++KG D +D+
Sbjct: 807 -----------------------EGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKK 843
Query: 436 SDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQD 484
D+ E+K K +K + + V VE H+ T ++
Sbjct: 844 GGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEE 892
Score = 35.0 bits (79), Expect = 0.31
Identities = 53/232 (22%), Positives = 91/232 (39%), Gaps = 42/232 (18%)
Query: 693 EFQTKTEEEEI--DRTPWGELEPS--DEESSEEEEEEESDEDKPDETGFITPADSGLITP 748
E + + EEEE+ ++P P +EE +EEEE + +E++ DE A+ G
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555
Query: 749 GGFSSVPAG----------METPELIELRKKKIEEAMDGSETPQLFTV-----LPEKRTA 793
G S G E E +KK+EE + T + PEK +
Sbjct: 556 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 615
Query: 794 TVGGAMM---GSTHIYDMSTVMSRKGPAPELQGVEVALAP------EELELDPMAMTQKY 844
V + + G + + K P P+ E +P EE P++ +
Sbjct: 616 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 675
Query: 845 EE--------HVREQQAQVE------KEDFSDMVAEHAAKQKQKKRKAQPQD 882
E+ V E +++ E KE+ V E ++K +K++ +P+D
Sbjct: 676 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 727
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 59.3 bits (142), Expect = 2e-08
Identities = 87/387 (22%), Positives = 152/387 (39%), Gaps = 22/387 (5%)
Query: 255 DENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEED 314
DE EM++ A+ + KE+ +E+ + EEE +S + +A E +E+
Sbjct: 88 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 147
Query: 315 TVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREK-DSTRSRGSDSPAADVEIEYVT 373
++E + + K + SE G EK + + G A+ E
Sbjct: 148 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 207
Query: 374 EEPEIYEPNFIFFKRIFEAFKLTDDVKKEK-EKEPEKLDKL---ENSAAPKKKGFEEEHK 429
EE ++ E + + + +L D K EK EK + K E +P K EE
Sbjct: 208 EEKKVEEKS----EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG 263
Query: 430 DSDDDSSDDEQEKKPEAPK--LSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKL 487
S S E++ K PK + +K +++ V E + VE A+ K
Sbjct: 264 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 323
Query: 488 LVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQ------ 541
+ + P+ ++K + K EK E P +K + E+ +
Sbjct: 324 EQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP--VKEEAVAEVVTITKSVKVHL 381
Query: 542 EKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGK-EFETR 600
EKE ++ K +EK + K G ++ D K K + ++G++ EGK E E
Sbjct: 382 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV--EGKEEVEQE 439
Query: 601 LKEKKPGDLSDELRISLGMPVGPNAHK 627
KEK G ++ ++ G+ + P K
Sbjct: 440 TKEKGSGREEEKGVVTNGLDLSPADEK 466
Score = 42.4 bits (98), Expect = 0.002
Identities = 65/349 (18%), Positives = 137/349 (39%), Gaps = 51/349 (14%)
Query: 161 EERAKQQGDHSLKEHELLEQQKRAAVLLEQE-----RQQEIAKMGTPVPRPP-QDMGQIG 214
E A+ +G+ + + E ++K V ++E + ++ K +PVP+ P ++ G+
Sbjct: 194 ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 253
Query: 215 V-RTPLGPRVAAPV----------GPVGPTPTVLPMGAPVPRP----RGPPPPPGDENRE 259
V ++P+ + +PV PV +P +PV + + P P E
Sbjct: 254 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 313
Query: 260 MDDPSVGPKIPQALEKILQLKES-RQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSV 318
+ K Q E+ ++KE+ ++E++ ++E+ + + + + E + V++
Sbjct: 314 AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI 373
Query: 319 SKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEI 378
+K K + K++ KP + ++ G+ + GSD A E + E+
Sbjct: 374 TKSVKVHLEKETKEEGKPLQQEKEKEKAGGE---GGSEEEGSDKGAKGSRKEDIAVNGEV 430
Query: 379 YEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKD---SDDDS 435
E ++E E+ K + S ++KG D +D+
Sbjct: 431 -----------------------EGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKK 467
Query: 436 SDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQD 484
D+ E+K K +K + + V VE H+ T ++
Sbjct: 468 GGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEE 516
Score = 35.0 bits (79), Expect = 0.31
Identities = 53/232 (22%), Positives = 91/232 (39%), Gaps = 42/232 (18%)
Query: 693 EFQTKTEEEEI--DRTPWGELEPS--DEESSEEEEEEESDEDKPDETGFITPADSGLITP 748
E + + EEEE+ ++P P +EE +EEEE + +E++ DE A+ G
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 749 GGFSSVPAG----------METPELIELRKKKIEEAMDGSETPQLFTV-----LPEKRTA 793
G S G E E +KK+EE + T + PEK +
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
Query: 794 TVGGAMM---GSTHIYDMSTVMSRKGPAPELQGVEVALAP------EELELDPMAMTQKY 844
V + + G + + K P P+ E +P EE P++ +
Sbjct: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
Query: 845 EE--------HVREQQAQVE------KEDFSDMVAEHAAKQKQKKRKAQPQD 882
E+ V E +++ E KE+ V E ++K +K++ +P+D
Sbjct: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351
>gi|72534686 Huntingtin interacting protein C isoform 1 [Homo
sapiens]
Length = 871
Score = 59.3 bits (142), Expect = 2e-08
Identities = 118/543 (21%), Positives = 198/543 (36%), Gaps = 124/543 (22%)
Query: 80 PPPMSAQLPGIPMPPPPLGLPPL-QPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLR---- 134
PPP PGIP P PP+GLPP+ Q PP PP PPG+ P PP +G PPPL
Sbjct: 3 PPPFMPP-PGIPPPFPPMGLPPMSQRPPAIPPMPPGI---LPPMLPP-MGAPPPLTQIPG 57
Query: 135 ---------------------------------VGEPVALSEE----------------- 144
G P AL E
Sbjct: 58 MVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQ 117
Query: 145 ---ERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQ-EIAKMG 200
E+ + + +A LL+ Q + + D K + Q K + ++ E+
Sbjct: 118 SVWEKPSVLKSKAELLLSQCPWKEYKSDTG-KPYYYNNQSKESRWTRPKDLDDLEVLVKQ 176
Query: 201 TPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREM 260
+ Q + Q P P+ P P GPTP +P G P P G + +
Sbjct: 177 EAAGKQQQQLPQTLQPQPPQPQPDPPPVPPGPTP--VPTGLLEPEPGG--------SEDC 226
Query: 261 DDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSK 320
D + Q + L+ S + QQEEEE S E E +S S
Sbjct: 227 DVLEATQPLEQGFLQQLEEGPSSSGQHQPQQEEEE-----------SKPEPERSGLSWSN 275
Query: 321 KEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYE 380
+EK ++ K+ R + V S +S ++ VT+
Sbjct: 276 REK-----AKQAFKELLRDKAVPSNASWEQAMKMV----------------VTDPRYSAL 314
Query: 381 PNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQ 440
P K+ F A+K ++++EKE +L E A + F E+H+ +
Sbjct: 315 PKLSEKKQAFNAYKAQ---REKEEKEEARLRAKE--AKQTLQHFLEQHERMTSTTRYRRA 369
Query: 441 EKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPV 500
E+ ++ R + ++ +A+ + + + ++ + L + +SV
Sbjct: 370 EQTFGELEVWAVVPERDRKEVYDDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNF 429
Query: 501 PRHWCFKRKYLQGKRGIEKPPF----ELPDFIKRTGI---QEMREALQEKEEQKTMKSKM 553
W ++YL ++ P F +L + K + +E AL+ +EE++ ++++
Sbjct: 430 QTTWSQAQQYL-----MDNPSFAQDHQLQNMDKEDALICFEEHIRALEREEEEERERARL 484
Query: 554 REK 556
RE+
Sbjct: 485 RER 487
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/122 (34%), Positives = 59/122 (48%), Gaps = 10/122 (8%)
Query: 30 QELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPG 89
Q+ K+ E+ A IQ +L + Q + +GI P G PPP + LPG
Sbjct: 519 QKRDEKIKELEAEIQ----QLRTQAQVLSSSSGIP-GPPAAPPLPGVGPPPPPPAPPLPG 573
Query: 90 -IPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPP--NLGPPPPLRVGEPVALSEEER 146
P+PPPP LP + PPPPPPP L G P PP + PPP + + P + +++
Sbjct: 574 GAPLPPPPPPLPGMMGIPPPPPPP--LLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKM 631
Query: 147 LK 148
K
Sbjct: 632 YK 633
Score = 40.0 bits (92), Expect = 0.010
Identities = 35/125 (28%), Positives = 49/125 (39%), Gaps = 16/125 (12%)
Query: 159 QQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTP 218
Q+ + Q+ D +KE E QQ R Q ++ + +P PP GV P
Sbjct: 512 QEAQAELQKRDEKIKELEAEIQQLRT--------QAQVLSSSSGIPGPPAAPPLPGVGPP 563
Query: 219 LGPRVAAPVG--PVGPTPTVLP--MGAPVPRPR----GPPPPPGDENREMDDPSVGPKIP 270
P G P+ P P LP MG P P P G PPPP P + +P
Sbjct: 564 PPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLP 623
Query: 271 QALEK 275
+++
Sbjct: 624 YGMKQ 628
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/122 (34%), Positives = 59/122 (48%), Gaps = 10/122 (8%)
Query: 30 QELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPG 89
Q+ K+ E+ A IQ +L + Q + +GI P G PPP + LPG
Sbjct: 519 QKRDEKIKELEAEIQ----QLRTQAQVLSSSSGIP-GPPAAPPLPGVGPPPPPPAPPLPG 573
Query: 90 -IPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPP--NLGPPPPLRVGEPVALSEEER 146
P+PPPP LP + PPPPPPP L G P PP + PPP + + P + +++
Sbjct: 574 GAPLPPPPPPLPGMMGIPPPPPPP--LLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKM 631
Query: 147 LK 148
K
Sbjct: 632 YK 633
Score = 40.0 bits (92), Expect = 0.010
Identities = 35/125 (28%), Positives = 49/125 (39%), Gaps = 16/125 (12%)
Query: 159 QQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTP 218
Q+ + Q+ D +KE E QQ R Q ++ + +P PP GV P
Sbjct: 512 QEAQAELQKRDEKIKELEAEIQQLRT--------QAQVLSSSSGIPGPPAAPPLPGVGPP 563
Query: 219 LGPRVAAPVG--PVGPTPTVLP--MGAPVPRPR----GPPPPPGDENREMDDPSVGPKIP 270
P G P+ P P LP MG P P P G PPPP P + +P
Sbjct: 564 PPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLP 623
Query: 271 QALEK 275
+++
Sbjct: 624 YGMKQ 628
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 58.2 bits (139), Expect = 3e-08
Identities = 69/287 (24%), Positives = 112/287 (39%), Gaps = 41/287 (14%)
Query: 80 PPPMSAQLPG------IPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMA---HPPNLGPP 130
PPP L I PPPP G P PPP PPPP + H P
Sbjct: 992 PPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKS 1051
Query: 131 PPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ---QKRAAVL 187
P G L + Q + ++ Q + K+ EL Q + V+
Sbjct: 1052 DPYSTGH--LREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVV 1109
Query: 188 LEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPR-VAAPVG-PVGPTPTVLPMGAPVPR 245
+++E K+ +P+ R + P P + APV P P + +G PV R
Sbjct: 1110 VKEE------KIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIR 1163
Query: 246 P---RGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESR------QEEMNSQQEEEEM 296
P PPP D++++ + PK P A +K L++K Q+ + +
Sbjct: 1164 PPEQNAPPPGAPDKDKQKQE----PKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKS 1219
Query: 297 ETDARSSLGQSASETEEDTVSV------SKKEKNRKRRNRKKKKKPQ 337
+D+ ++A E EE ++ ++KEK R R+ R + ++ +
Sbjct: 1220 SSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDE 1266
Score = 51.2 bits (121), Expect = 4e-06
Identities = 101/511 (19%), Positives = 172/511 (33%), Gaps = 145/511 (28%)
Query: 78 AAPPPMSAQLPGIPM-PPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNL-GPPPPLR- 134
A P + Q P + + PP PL PP PP P PPP P +HPP + P P++
Sbjct: 227 AVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQP--VQSHPPIIAATPQPVKT 284
Query: 135 ------------------VGEPVALSEEER-LKLAQQQAALL----MQQEERAKQQGDHS 171
+ EP +L E + KL Q++ + +++ QQ
Sbjct: 285 KKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAP 344
Query: 172 LKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRP-----------------PQDMGQIG 214
K ++ EQ K + +L++ ++ A P +P P DM I
Sbjct: 345 EKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTI- 403
Query: 215 VRTPLGPRVAAPVGPVG---------------PTPTVLPMGAPVP-----RPRGPPPPPG 254
++ L R G P V+ M + R P P
Sbjct: 404 -KSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPE 462
Query: 255 DENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEED 314
+ + P+V P K++ S +S + + D+ Q +E +E
Sbjct: 463 EPVVAVSSPAVPPP-----TKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQ 517
Query: 315 TVSV---------------SKKEKNRKRRNRKKKKK----------------PQRVRGVS 343
+V KKEK++K + ++K K+ P++ + +
Sbjct: 518 LKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNN 577
Query: 344 SESSGDREKDSTRSRGSDSPAADVEIE--------------------------------Y 371
S +S +K+ + P + E E
Sbjct: 578 SSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHII 637
Query: 372 VTEEPEIYEPNFIFFKRIFEAFK----------LTDDVKKEKEKEPEKLDKLENSAAPKK 421
+ EP + N + FE K +T ++K+++ + EK+D + S+ K
Sbjct: 638 QSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKG 697
Query: 422 KGFEEEHKDSDDDSSDDEQEKKPEAPKLSKK 452
E S+ SSD E + APK KK
Sbjct: 698 FSSSESESSSESSSSDSEDSETEMAPKSKKK 728
Score = 50.1 bits (118), Expect = 9e-06
Identities = 53/191 (27%), Positives = 67/191 (35%), Gaps = 33/191 (17%)
Query: 79 APPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGL-----------GFPMAHPPNL 127
AP P+ Q P P PPP P Q PPPPPPPP + F P L
Sbjct: 749 APAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVL 808
Query: 128 GPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHS----LKEHELLEQQKR 183
P P V +P+ + L L Q + Q +HS L +H ++
Sbjct: 809 EPQLPGSVFDPIGHFTQPILHLPQPEL------PPHLPQPPEHSTPPHLNQHAVVSPPAL 862
Query: 184 AAVLLEQ-ERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAP 242
L +Q R A P P P + +TPL P P+ P VL
Sbjct: 863 HNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPL-----LPQPPMAQPPQVL----- 912
Query: 243 VPRPRGPPPPP 253
PP PP
Sbjct: 913 -LEDEEPPAPP 922
Score = 43.5 bits (101), Expect = 9e-04
Identities = 67/268 (25%), Positives = 89/268 (33%), Gaps = 38/268 (14%)
Query: 7 EPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLN 66
+PP Q PPPPPP + + AP + + I
Sbjct: 756 QPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKS-----------SPPPFIATQ 804
Query: 67 RPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPN 126
PVL + P P + +P P LPP P PP PP L + PP
Sbjct: 805 VPVLEPQLPGSVFDPIGHFTQPILHLPQPE--LPPHLPQPPEHSTPPHLN-QHAVVSPPA 861
Query: 127 LGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRA-- 184
L P + P +AA L + R +L + LL Q A
Sbjct: 862 LHNALPQQPSRP------------SNRAAALPPKPARPPAVSP-ALTQTPLLPQPPMAQP 908
Query: 185 -AVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAA-----PVGPVGPTPTV-- 236
VLLE E + Q + ++ TPL P V P P P P+V
Sbjct: 909 PQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQ 968
Query: 237 -LPMGAPVPRPRGPPPPPGDENREMDDP 263
L P P P P PPP +++ P
Sbjct: 969 QLQQQPPPPPPPQPQPPPQQQHQPPPRP 996
Score = 34.3 bits (77), Expect = 0.53
Identities = 41/162 (25%), Positives = 59/162 (36%), Gaps = 34/162 (20%)
Query: 68 PVLRGEDGDKAAPPPMSAQLPGIP-MPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPP- 125
P LR E LP P M P +G P ++PP PPP P
Sbjct: 1127 PSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKT 1186
Query: 126 -----------NLG---------PPPPLRVGEP----------VALSEEERLKLAQQQAA 155
N+G P P + A +EER K + QA
Sbjct: 1187 PVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAE 1246
Query: 156 LLMQQEERAKQQGDHSLKEHELLEQQKRA--AVLLEQERQQE 195
+++ER +Q+ S ++ + LEQ +RA QE+QQ+
Sbjct: 1247 HAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQ 1288
Score = 33.1 bits (74), Expect = 1.2
Identities = 13/38 (34%), Positives = 19/38 (50%)
Query: 234 PTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQ 271
P +P P P + PPPPP + ++ P P +PQ
Sbjct: 750 PAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQ 787
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,805,559
Number of Sequences: 37866
Number of extensions: 3537315
Number of successful extensions: 88619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1102
Number of HSP's successfully gapped in prelim test: 1675
Number of HSP's that attempted gapping in prelim test: 28682
Number of HSP's gapped (non-prelim): 33187
length of query: 895
length of database: 18,247,518
effective HSP length: 111
effective length of query: 784
effective length of database: 14,044,392
effective search space: 11010803328
effective search space used: 11010803328
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.