Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 55742734
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55742734 pleckstrin homology domain containing, family G
(with RhoGef domain) member 4 isoform 1 [Homo sapiens]
(1191 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193211598 pleckstrin homology domain containing, family G (wi... 2401 0.0
gi|193211596 pleckstrin homology domain containing, family G (wi... 2401 0.0
gi|193211594 pleckstrin homology domain containing, family G (wi... 2401 0.0
gi|55742734 pleckstrin homology domain containing, family G (wit... 2401 0.0
gi|193211603 pleckstrin homology domain containing, family G (wi... 2042 0.0
gi|148529025 pleckstrin homology domain containing, family G (wi... 427 e-119
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 400 e-111
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 194 4e-49
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 190 8e-48
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 190 8e-48
gi|71274186 hypothetical protein LOC85449 [Homo sapiens] 187 7e-47
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 182 2e-45
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 182 2e-45
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 178 3e-44
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 176 9e-44
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 176 9e-44
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 175 2e-43
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 175 2e-43
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 128 4e-29
gi|71274148 pleckstrin homology domain containing, family G (wit... 125 3e-28
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 114 7e-25
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 114 7e-25
gi|55749621 pleckstrin homology domain containing, family G, mem... 79 3e-14
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 77 1e-13
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 74 6e-13
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 68 5e-11
gi|39930351 dynamin binding protein [Homo sapiens] 67 1e-10
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 61 7e-09
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 60 2e-08
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 60 2e-08
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2401 bits (6222), Expect = 0.0
Identities = 1191/1191 (100%), Positives = 1191/1191 (100%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2401 bits (6222), Expect = 0.0
Identities = 1191/1191 (100%), Positives = 1191/1191 (100%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2401 bits (6222), Expect = 0.0
Identities = 1191/1191 (100%), Positives = 1191/1191 (100%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 2401 bits (6222), Expect = 0.0
Identities = 1191/1191 (100%), Positives = 1191/1191 (100%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
Query: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
Sbjct: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
Query: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
Sbjct: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
Query: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
Sbjct: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
Query: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
Query: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
Query: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
Query: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
Query: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
Query: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
Query: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
Query: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
Query: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
Query: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
Query: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
Query: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
Query: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
Query: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
Query: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 2042 bits (5290), Expect = 0.0
Identities = 1047/1191 (87%), Positives = 1063/1191 (89%), Gaps = 81/1191 (6%)
Query: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
Sbjct: 1 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE 60
Query: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES 120
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG
Sbjct: 61 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGTR 120
Query: 121 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL 180
D G ++ + SP L S+ E+ +LL S +P+P
Sbjct: 121 DVQGRAVL--------LLCAHSPAWLQSECSS-----QELIRLLLYLRS---IPRP---- 160
Query: 181 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR 240
E+ A G+ L R +CA S +
Sbjct: 161 -------EVQALGLTVLVDAR---------ICAPSSSLFS-------------------- 184
Query: 241 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ 300
GL+ L +A A L G + L+E VPSGLQLEQ
Sbjct: 185 ------GLSQLQEAAPGAVYQVLLVGSTLLKE-------------------VPSGLQLEQ 219
Query: 301 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 360
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
Sbjct: 220 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA 279
Query: 361 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 420
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
Sbjct: 280 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA 339
Query: 421 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 480
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
Sbjct: 340 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA 399
Query: 481 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 540
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
Sbjct: 400 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE 459
Query: 541 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 600
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
Sbjct: 460 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD 519
Query: 601 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 660
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
Sbjct: 520 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV 579
Query: 661 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 720
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
Sbjct: 580 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP 639
Query: 721 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 780
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
Sbjct: 640 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG 699
Query: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 840
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
Sbjct: 700 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH 759
Query: 841 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 900
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
Sbjct: 760 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF 819
Query: 901 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 960
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
Sbjct: 820 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH 879
Query: 961 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
Sbjct: 880 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 939
Query: 1021 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 1080
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
Sbjct: 940 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS 999
Query: 1081 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1140
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
Sbjct: 1000 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE 1059
Query: 1141 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1191
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Sbjct: 1060 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV 1110
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 427 bits (1099), Expect = e-119
Identities = 235/472 (49%), Positives = 313/472 (66%), Gaps = 35/472 (7%)
Query: 715 ASPTVPPPGSSDPRSL---NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 771
+SP+ P D R +RL+ ++AEM+ATEREY+R L Y ++NYFPE++R D+PQGL
Sbjct: 785 SSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGL 844
Query: 772 RGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRS 831
RG+ +FGNLEKL DFH FLRELE C P V +FLRH QFGMY +YSKNKP+S
Sbjct: 845 RGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQS 904
Query: 832 DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR--ACG-GPTQEL 888
DAL+SS+G+ FFKDKQ+ LGD +DLASYLL+P+QR+ KYALLLQ+L + +CG QEL
Sbjct: 905 DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQEL 964
Query: 889 SALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFL 948
LR A+ +V FQLRHGNDLLAMDAI+GCDVNLKEQGQL +DEF+V GR K +R +FL
Sbjct: 965 GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFL 1024
Query: 949 FEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWF-RRRKARDTFVL 1007
FE+L+LFSK + D + YK+SFK A++G+TE G+S LRFEIWF RRRK++DT++L
Sbjct: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
Query: 1008 QASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEE-------- 1059
QASS +K AWT I +LWRQA+ ++E+R+ EM SMG+GN+ F D+ P +
Sbjct: 1085 QASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVIS 1144
Query: 1060 -------AINDRTVNYVLKCREVRSRASIAVAPFDHDSLY------LGASNSLPGDPASC 1106
++DR + ++K E + R S AV+ DH + + + S++ S
Sbjct: 1145 DRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSS 1204
Query: 1107 SVLGSLNLHLYRDPALLGLRCPLYPSFP-------EEAALEAEAELGGQPSL 1151
S+LGSL L + PA GL P + + EE E E E G Q ++
Sbjct: 1205 SILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAV 1256
Score = 173 bits (438), Expect = 1e-42
Identities = 153/490 (31%), Positives = 223/490 (45%), Gaps = 45/490 (9%)
Query: 53 AGATQDE------ELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPS-GVESL 105
A TQ+E + Q +P K + P+ G A R S P S G ++
Sbjct: 38 ASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAA 97
Query: 106 LCPMSSHLS-------LAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSD--------P 150
C S H + L TP V PG ++ S + +D P
Sbjct: 98 ACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNP 157
Query: 151 VGLGD-PLSEISKLLEAAPSGSG-----LPKPADCLLAQDLCWELLASGMATLPGTRDVQ 204
G D P + E P G+G +PK D+ ELL SG+ TLPGTRD
Sbjct: 158 SGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQV-----LDVSQELLQSGVVTLPGTRDRH 212
Query: 205 GRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLF 264
GRAV+ + S W + S EL RLLLY SIPR EV+ LGL VLVDAR + ++
Sbjct: 213 GRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVS 272
Query: 265 SGLSQLQEAAPGAVYQVLLV---GSTLLKEVPSGLQLEQLPS-QSLLTHIPTAGLPTSLG 320
LS LQ ++ +LL+ S + + +Q E + S +++ + + L L
Sbjct: 273 QALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLD 332
Query: 321 GGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVL 380
G PY H W+ FR+RLE NC+ A LQ + S+ P EV +L+ Q E +
Sbjct: 333 GSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETM 392
Query: 381 MQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTL 440
M+ VL+ P L L+ +GG L L++ E + D R ++ A LYDRVD +H+L L
Sbjct: 393 MKLVLEDPLLVSLRLEGGTVLARLRR---EELGTEDSRDTLEAATSLYDRVDEEVHRLVL 449
Query: 441 QSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQ 500
SN R+Q LE ++ L + G Q Q G +E + + +M+ + +
Sbjct: 450 TSNNRLQQLEHLRELASLLEGNDQQSC---QKGLQLAKENPQRTEEMVQDFRRGLSAV-- 504
Query: 501 VAQEQVRQGE 510
V+Q + R+GE
Sbjct: 505 VSQAECREGE 514
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 400 bits (1028), Expect = e-111
Identities = 344/1051 (32%), Positives = 497/1051 (47%), Gaps = 136/1051 (12%)
Query: 118 GESDTPGVGLV---GDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLP 174
GE + G GL+ G GP + +P L++ G GD + E + A S S P
Sbjct: 470 GERELEGPGLLCMAGHTGPEGPLSDTPTP-PLETVQEGKGDNIPEEA----LAVSVSDHP 524
Query: 175 KPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLY 234
D+ W+L+ASG L G D GRA+L + P + S L L Y
Sbjct: 525 ---------DVAWDLMASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLHY 574
Query: 235 LRSIPRPEVQALGLTVLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVP 293
L S+ RP++Q LGL+VL+D R P +L LSQLQ++ + Q LL+ + ++P
Sbjct: 575 LHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDLP 632
Query: 294 S---GLQLEQLPSQSLLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
+ G Q ++ S++ L + L LGG W++ + + L + CQ
Sbjct: 633 TELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLG 692
Query: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVP 409
++ AIE ++ +P E VG +Q+VL P L LQ GG L L+
Sbjct: 693 SVRQAIEELEGAAEPEEEEAVGMPKP-----LQKVLADPRLTALQRDGGAILMRLRS--- 744
Query: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWL 469
+P + LY VD +HQL SN +Q E Q L L Q+ WL
Sbjct: 745 ----TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQWL 796
Query: 470 QQVGWPALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPP 527
G L P +L L + + F+ QE++ Q + L A E +
Sbjct: 797 SGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENAT 849
Query: 528 GARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVV 587
+ L + F + L Q L A RL + F++A W +EG A L PG
Sbjct: 850 SQKVLDI------FEQRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGRE 900
Query: 588 LQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL--EA 645
L R P+ F++M ALA LGS A +E ARCQ+ + Q + EA
Sbjct: 901 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 960
Query: 646 SLK-------------------LPPVGSTASLCVSQVPA---APAHPPLRKAYSFDRNLG 683
S + P S +SL + P AP+H L G
Sbjct: 961 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 1020
Query: 684 QSLSEPA------------------------CHCHHAATIAACRRPEAGGGALPQASPTV 719
L+ A C + R P+ G V
Sbjct: 1021 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWG--------V 1072
Query: 720 PPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLF 779
P RS++ Q +++E++A E++YV L + PEL P+ LRG A
Sbjct: 1073 GTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAAL 1127
Query: 780 GNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYG 839
E+LR FH FLREL+ C HP R+ FLRH QF +YA Y K++ + + +++
Sbjct: 1128 SARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS 1187
Query: 840 HTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGP-TQELSALREAQSLV 898
K +A G +L A L +P++++ +Y LL+EL R G + E AL A L+
Sbjct: 1188 -PLSKGSMEA-GPYLPRA--LQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLL 1243
Query: 899 HFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKP 958
Q G DLLA++A++GC+++LKEQGQL+ +D F V GR K +R +FLFE LLLFSK
Sbjct: 1244 REQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKL 1303
Query: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAW 1018
+ G + F YK++FK AD+GLTE G+S L FE+WFRRR+AR+ + LQA+S IK W
Sbjct: 1304 KGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKW 1363
Query: 1019 TADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSR 1078
T+ I+ LLWRQA HNKE+R+ +MVSMG+GNK F DI +A+ +RT++ +L R R+R
Sbjct: 1364 TSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTR 1419
Query: 1079 ASIAVAPFDHDSLYLGASNSLPG-DPASCSV 1108
AS+AV+ F+H A SLPG P +CS+
Sbjct: 1420 ASVAVSSFEH------AGPSLPGLSPGACSL 1444
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 194 bits (493), Expect = 4e-49
Identities = 111/309 (35%), Positives = 175/309 (56%), Gaps = 9/309 (2%)
Query: 729 SLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDF 788
SL R VL E+V TER+YVR L Y +E Y + VP ++G+ +FGN+ ++ D+
Sbjct: 1966 SLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDW 2025
Query: 789 HCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQ 848
H FFL ELE C P ++ F++H + MY Y +NKP+S+ ++S Y TFF+D +Q
Sbjct: 2026 HRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQ 2085
Query: 849 ALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL 908
LG L L L+KP+QR+ KY LLL++ + + + S L A ++ R ND+
Sbjct: 2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDM 2145
Query: 909 LAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV------RRIFLFEELLLFSKPRHGP 962
+ + +QG D + QG+L+ QD F+V T + + RRIFLFE++++FS+P
Sbjct: 2146 MNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAGLLPRCRERRIFLFEQIVIFSEPLDKK 2204
Query: 963 TG--VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA 1020
G + F +K S K++ L L E N +F + R +TF+L +SS +++Q W
Sbjct: 2205 KGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIH 2264
Query: 1021 DISHLLWRQ 1029
+I+ +L Q
Sbjct: 2265 EINQILENQ 2273
Score = 174 bits (442), Expect = 3e-43
Identities = 104/317 (32%), Positives = 168/317 (52%), Gaps = 16/317 (5%)
Query: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
+S R + ++AE++ TE+ YVR L M+ Y E+ ++P G+ + +FGN++++
Sbjct: 1288 KSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
Query: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
+FH + FL+ELE + P V + F+ +F MY Y KNKP S L+ + ++F +
Sbjct: 1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDE 1407
Query: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
QQ G ++SYL+KP+QR+ KY LLL+EL C E+ E V +
Sbjct: 1408 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVP---KRA 1464
Query: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
ND + + ++G D N++ QG+L+ Q+ F ++R GR R +FLFE L+FSK
Sbjct: 1465 NDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRE---RHLFLFEMSLVFSKE 1521
Query: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
+G + YK ++LG+TE +F +W R D VL+ASS+ KQ
Sbjct: 1522 VKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQD 1581
Query: 1018 WTADISHLLWRQAVHNK 1034
W I ++ + +H K
Sbjct: 1582 WIKHIREVIQERTIHLK 1598
Score = 55.1 bits (131), Expect = 4e-07
Identities = 80/327 (24%), Positives = 138/327 (42%), Gaps = 34/327 (10%)
Query: 152 GLGDPLSEISKLLE--AAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVL 209
G G+ E +K L AA SG K D + A D+ +L +A L G RD +G +L
Sbjct: 31 GAGEGAEEAAKDLADIAAFFRSGFRKN-DEMKAMDVL-PILKEKVAYLSGGRDKRGGPIL 88
Query: 210 LLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQ 269
A S ++L RL+ YL IP EV G TV+VD R + S+ L
Sbjct: 89 TFPARSN---HDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMR-GSKWDSIKPLLKI 144
Query: 270 LQEAAPGAVYQVLLV--------GSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGG 321
LQE+ P ++ L++ T + + + L + + L G
Sbjct: 145 LQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDG 204
Query: 322 GLPYCHQAWLDFRRRLEALLQNCQAACALLQGA--IESVKAVPQPMEPGEVGQLLQQTEV 379
L Y H+ W++ R E + N + L+ I + K +PQ +E ++++
Sbjct: 205 CLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGAR--NMIEEHSQ 262
Query: 380 LMQQVLDSPWLAWLQCQGGRELTWLK--QEVPEVTL---SPDYRTAMDKADELYDRVDGL 434
L ++V+ +P + L +G + L ++ + P+ + D + + K + DR+
Sbjct: 263 LKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHST 321
Query: 435 ---LHQLTLQSNQRIQALELVQTLEAR 458
LHQ+ ++ L+L Q + R
Sbjct: 322 RQHLHQM-----WHVRKLKLDQCFQLR 343
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 190 bits (482), Expect = 8e-48
Identities = 230/895 (25%), Positives = 376/895 (42%), Gaps = 78/895 (8%)
Query: 190 LASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 249
L A L G R G V+ + PA+ SE +E ++ YL SIP + +G
Sbjct: 103 LKKRFAYLSGGRGQDGSPVITFPDY-PAF--SEIPDKEFQNVMTYLTSIPSLQDAGIGFI 159
Query: 250 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGST------------------LLKE 291
+++D R +S+ + + ++ + P + VL++ T +
Sbjct: 160 LVIDRRR-DKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMK 218
Query: 292 VPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALL 351
VP + L +P L +I + L LGG L YCH WL R +E+ + +L
Sbjct: 219 VPV-IMLSSVPD--LHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQML 275
Query: 352 QGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRE-LTWLKQEVPE 410
Q + P + +L + + LA + E L L+ E E
Sbjct: 276 QSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSE 335
Query: 411 VTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQ 470
+++ D L +++ + Q LE L E G +++ L
Sbjct: 336 PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 395
Query: 471 QVGWP--ALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP 526
+ G ++ LL+ SF+E VA E+ R + L G + +D
Sbjct: 396 AASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDS 455
Query: 527 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAEL------E 580
+ LR +FS +A+R L+ + L + ++ W +EG +LA
Sbjct: 456 IRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQS 515
Query: 581 QERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALD 640
Q+ LQ+++ + ++ + ++ + + R + + Q + +
Sbjct: 516 QDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQK-QASMEEVF 574
Query: 641 QKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIA 700
+ +ASLK T + P AP L K+ + + SE + A
Sbjct: 575 HRRQASLKKLAARQTRPV----QPVAPRPEALAKSPCPSPGIRRG-SENSSSEGGALRRG 629
Query: 701 ACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-VLAEMVATEREYVRALEYTMENYF 759
RR ++ Q + + SL L+ V++E++ TER YV L +E Y
Sbjct: 630 PYRRAKSEMSESRQGRGSA----GEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYA 685
Query: 760 PELDRPDVPQ----GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHR 815
E+D P + GL ++ LFGN+E++ FH FLRELE T P V FL
Sbjct: 686 AEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERM 745
Query: 816 VQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLL 874
F +Y Y +NKPRS++L FF++ Q+ L L L SYLLKP+QR+ KY LLL
Sbjct: 746 EDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLL 805
Query: 875 QEL---ARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931
+E+ +R C G L+EA S + L+ ND + + AI G D NL + G+L+ Q
Sbjct: 806 KEMLKYSRNCEGAED----LQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQG 861
Query: 932 EFVVRTGR---HKSV----------RRIFLFEELLLFSKPR----HGPTGVDTFAYKRSF 974
F V T H V R +FL E+ +LF K R G +++YK+S
Sbjct: 862 SFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSL 921
Query: 975 KMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQ 1029
MA +G+TE +FEIW+ R+ + +++QA + IK AW +I +L Q
Sbjct: 922 NMAAVGITENVKGDAKKFEIWYNARE--EVYIVQAPTPEIKAAWVNEIRKVLTSQ 974
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 190 bits (482), Expect = 8e-48
Identities = 230/895 (25%), Positives = 376/895 (42%), Gaps = 78/895 (8%)
Query: 190 LASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 249
L A L G R G V+ + PA+ SE +E ++ YL SIP + +G
Sbjct: 50 LKKRFAYLSGGRGQDGSPVITFPDY-PAF--SEIPDKEFQNVMTYLTSIPSLQDAGIGFI 106
Query: 250 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGST------------------LLKE 291
+++D R +S+ + + ++ + P + VL++ T +
Sbjct: 107 LVIDRRR-DKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMK 165
Query: 292 VPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALL 351
VP + L +P L +I + L LGG L YCH WL R +E+ + +L
Sbjct: 166 VPV-IMLSSVPD--LHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQML 222
Query: 352 QGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRE-LTWLKQEVPE 410
Q + P + +L + + LA + E L L+ E E
Sbjct: 223 QSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSE 282
Query: 411 VTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQ 470
+++ D L +++ + Q LE L E G +++ L
Sbjct: 283 PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 342
Query: 471 QVGWP--ALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP 526
+ G ++ LL+ SF+E VA E+ R + L G + +D
Sbjct: 343 AASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDS 402
Query: 527 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAEL------E 580
+ LR +FS +A+R L+ + L + ++ W +EG +LA
Sbjct: 403 IRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQS 462
Query: 581 QERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALD 640
Q+ LQ+++ + ++ + ++ + + R + + Q + +
Sbjct: 463 QDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQK-QASMEEVF 521
Query: 641 QKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIA 700
+ +ASLK T + P AP L K+ + + SE + A
Sbjct: 522 HRRQASLKKLAARQTRPV----QPVAPRPEALAKSPCPSPGIRRG-SENSSSEGGALRRG 576
Query: 701 ACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-VLAEMVATEREYVRALEYTMENYF 759
RR ++ Q + + SL L+ V++E++ TER YV L +E Y
Sbjct: 577 PYRRAKSEMSESRQGRGSA----GEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYA 632
Query: 760 PELDRPDVPQ----GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHR 815
E+D P + GL ++ LFGN+E++ FH FLRELE T P V FL
Sbjct: 633 AEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERM 692
Query: 816 VQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLL 874
F +Y Y +NKPRS++L FF++ Q+ L L L SYLLKP+QR+ KY LLL
Sbjct: 693 EDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLL 752
Query: 875 QEL---ARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931
+E+ +R C G L+EA S + L+ ND + + AI G D NL + G+L+ Q
Sbjct: 753 KEMLKYSRNCEGAED----LQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQG 808
Query: 932 EFVVRTGR---HKSV----------RRIFLFEELLLFSKPR----HGPTGVDTFAYKRSF 974
F V T H V R +FL E+ +LF K R G +++YK+S
Sbjct: 809 SFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSL 868
Query: 975 KMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQ 1029
MA +G+TE +FEIW+ R+ + +++QA + IK AW +I +L Q
Sbjct: 869 NMAAVGITENVKGDAKKFEIWYNARE--EVYIVQAPTPEIKAAWVNEIRKVLTSQ 921
>gi|71274186 hypothetical protein LOC85449 [Homo sapiens]
Length = 1200
Score = 187 bits (474), Expect = 7e-47
Identities = 167/538 (31%), Positives = 244/538 (45%), Gaps = 52/538 (9%)
Query: 86 TVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGA 145
T E +S+ GP +LC + S G GP+ A PS L+
Sbjct: 485 TPEKASLQHNGPW-----KVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATA-PSPLTEEK 538
Query: 146 LDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQG 205
G P E LE P G P+P L ++ S +A LPG RD G
Sbjct: 539 AALPEASAGSP--ERGPTLEEEPPG---PEPRIGALGV----KVFRSRIACLPGGRDRAG 589
Query: 206 RAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFS 265
R +LL+ AW C+ E+ +LL YL +IPRPE +A GL VL+DAR P L S
Sbjct: 590 RPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVS 649
Query: 266 GLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPS---------QSLLTHIPTAGLP 316
L Q P ++ +L +G E + LQL+ LP ++L H+ + LP
Sbjct: 650 ALQATQAQVPASIRAILFLG-----EKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLP 704
Query: 317 TSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQ 376
L G PYCH W+ F ++L+ L + A +LLQ +IE + P E + L +
Sbjct: 705 AVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSK 764
Query: 377 TEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLH 436
++ LM+ VL P L LQ +GG L L+ + + SPD R+ + A LY VD LH
Sbjct: 765 SKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLH 824
Query: 437 QLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEE--AGEPSLDMLLQAQGS 494
L SN + LEL L E+ +HQ+ W++Q G L+ + SL+ + +A
Sbjct: 825 VLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAE 884
Query: 495 FQELYQVAQEQVRQGEKFLQP-----LTGWEAAELD----PPGARFL----ALRAQLTEF 541
F+ + A Q R+G + + T A E + P A F A +A+LT F
Sbjct: 885 FENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHF 944
Query: 542 SRALAQRCQRLADAERLFQLFR--EALTWAE-EGQRVLAELEQERPGVVL--QQLQLH 594
A A+R + D E L L R + +TW + Q ++A+L ++ V Q +LH
Sbjct: 945 YMA-AER--QRTDLETLLHLHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLH 999
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 182 bits (461), Expect = 2e-45
Identities = 109/323 (33%), Positives = 179/323 (55%), Gaps = 12/323 (3%)
Query: 715 ASPTVP--PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLR 772
A PT P P ++L VL E+V TE++YV+ L +E + ++ VP+ +R
Sbjct: 1910 APPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR 1969
Query: 773 GQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSD 832
G+ +FGN+ ++ D+H FFL ELE C + R+A F++H + +Y Y +NKPRS+
Sbjct: 1970 GKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSE 2029
Query: 833 ALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 892
+++ Y +F++ +Q + L L+ +L+KPIQR+ KY LLL++ R E S +
Sbjct: 2030 YIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIE 2088
Query: 893 EAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVV------RTGRHKSVRRI 946
+A L+ + ND++ + +QG + L QG+L++QD F V R K RR+
Sbjct: 2089 KAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE-RRV 2147
Query: 947 FLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFV 1006
FLFE++++FS+ + + +KRS KM L L E N +F + R+ + V
Sbjct: 2148 FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVV 2205
Query: 1007 LQASSLAIKQAWTADISHLLWRQ 1029
LQA++ I+QAW DI+ +L Q
Sbjct: 2206 LQAANADIQQAWVQDINQVLETQ 2228
Score = 178 bits (451), Expect = 3e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
Query: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
Query: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
Query: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
Query: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
Query: 1018 WTADISHLLWRQAVHNK 1034
W +I ++ + +H K
Sbjct: 1571 WIKNIREVIQERIIHLK 1587
Score = 54.3 bits (129), Expect = 7e-07
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
Query: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
Query: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
Query: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
Query: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 182 bits (461), Expect = 2e-45
Identities = 109/323 (33%), Positives = 179/323 (55%), Gaps = 12/323 (3%)
Query: 715 ASPTVP--PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLR 772
A PT P P ++L VL E+V TE++YV+ L +E + ++ VP+ +R
Sbjct: 213 APPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR 272
Query: 773 GQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSD 832
G+ +FGN+ ++ D+H FFL ELE C + R+A F++H + +Y Y +NKPRS+
Sbjct: 273 GKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSE 332
Query: 833 ALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 892
+++ Y +F++ +Q + L L+ +L+KPIQR+ KY LLL++ R E S +
Sbjct: 333 YIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIE 391
Query: 893 EAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVV------RTGRHKSVRRI 946
+A L+ + ND++ + +QG + L QG+L++QD F V R K RR+
Sbjct: 392 KAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE-RRV 450
Query: 947 FLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFV 1006
FLFE++++FS+ + + +KRS KM L L E N +F + R+ + V
Sbjct: 451 FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVV 508
Query: 1007 LQASSLAIKQAWTADISHLLWRQ 1029
LQA++ I+QAW DI+ +L Q
Sbjct: 509 LQAANADIQQAWVQDINQVLETQ 531
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 178 bits (451), Expect = 3e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
Query: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
Query: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
Query: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
Query: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
Query: 1018 WTADISHLLWRQAVHNK 1034
W +I ++ + +H K
Sbjct: 1571 WIKNIREVIQERIIHLK 1587
Score = 54.3 bits (129), Expect = 7e-07
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
Query: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
Query: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
Query: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
Query: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
[Homo sapiens]
Length = 985
Score = 176 bits (447), Expect = 9e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 736 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 791
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
Query: 792 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 850
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
Query: 851 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 907
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 734
Query: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 954
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
Query: 955 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 1010
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 852
Query: 1011 SLAIKQAWTADISHLLWRQ 1029
++ +K W +I ++L +Q
Sbjct: 853 NVDVKMTWLKEIRNILLKQ 871
Score = 50.4 bits (119), Expect = 1e-05
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 223 CSSQELI-RLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQV 281
C +E+I ++L YL SI R T+++D R+ SS S L ++ + PG ++ V
Sbjct: 29 CIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLDTWSSLKIS-LQKISASFPGNLHLV 87
Query: 282 LLVGSTLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYC 326
L++ T ++ L + L S S LLT+I L LGG L YC
Sbjct: 88 LVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYC 147
Query: 327 HQAWLDFRRRLEALLQNCQAACALLQ 352
H W+ FR +E + +LQ
Sbjct: 148 HSEWIIFRNAIENFALTVKEMAQMLQ 173
>gi|153791325 MCF.2 cell line derived transforming sequence isoform b
[Homo sapiens]
Length = 925
Score = 176 bits (447), Expect = 9e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 736 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 791
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 499 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 558
Query: 792 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 850
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 559 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 618
Query: 851 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 907
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 619 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 674
Query: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 954
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 675 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 734
Query: 955 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 1010
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 735 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 792
Query: 1011 SLAIKQAWTADISHLLWRQ 1029
++ +K W +I ++L +Q
Sbjct: 793 NVDVKMTWLKEIRNILLKQ 811
Score = 37.7 bits (86), Expect = 0.066
Identities = 18/47 (38%), Positives = 23/47 (48%)
Query: 306 LLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQ 352
LLT+I L LGG L YCH W+ FR +E + +LQ
Sbjct: 67 LLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQ 113
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
Length = 580
Score = 175 bits (444), Expect = 2e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215
Query: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275
Query: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335
Query: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395
Query: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455
Query: 1017 AWTADISHLLWRQ 1029
AW ++ +L Q
Sbjct: 456 AWIKHVAQILESQ 468
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
Length = 619
Score = 175 bits (444), Expect = 2e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
Query: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
Query: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
Query: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
Query: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
Query: 1017 AWTADISHLLWRQ 1029
AW ++ +L Q
Sbjct: 495 AWIKHVAQILESQ 507
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 128 bits (321), Expect = 4e-29
Identities = 212/964 (21%), Positives = 372/964 (38%), Gaps = 160/964 (16%)
Query: 188 ELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALG 247
E L A L G R G ++ S ++ + ++ YL SIP E ++G
Sbjct: 43 EQLHRQFAILSGGRGEDGAPIITFPEFSGF---KHIPDEDFLNVMTYLTSIPSVEAASIG 99
Query: 248 LTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLL--------------KEVP 293
V++D R SS+ + L+++ A PG + + ++ + E
Sbjct: 100 FIVVIDRRR-DKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFK 158
Query: 294 SGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQ 352
+ + + + S S L +I + L LGG L Y H W++ R +E + +LQ
Sbjct: 159 TKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQ 218
Query: 353 --GAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLA-WLQCQGGRELTWLKQEVP 409
G+ + +P+ M L ++LM L L+ G + T L
Sbjct: 219 TFGSCLATAELPRSM--------LSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQE 270
Query: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLH-QIEVW 468
T P+ + +++ L +T +Q E + S H ++
Sbjct: 271 PATKCPNSKLNLNQ-----------LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQC 319
Query: 469 LQQVGWPALEEAGEPSLDMLLQAQGSF-------QELYQVAQEQVRQGEKFLQPLTGWEA 521
LQ + + +LD LL+ Q F + Q+ +E + EK +PL +
Sbjct: 320 LQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQL 379
Query: 522 AEL-------------DPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTW 568
L D R + LR +F ++ L + + + W
Sbjct: 380 LALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQW 439
Query: 569 AEEGQRVLAELE----QERPGVVLQQLQLHW-----TRHPDLPPAHFRKMWALATGLGSE 619
E G +LA Q R GV + + +P L P F + L L ++
Sbjct: 440 CEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAK 499
Query: 620 AIRQECRWAWARCQDTW---------LALDQKLEASLKLPPVGSTASLCVSQVP----AA 666
A Q+ Q+ + LA Q P S+ S+ +
Sbjct: 500 AKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSV 559
Query: 667 PAHPPLR-------------KAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALP 713
P PLR + D + SE HH E G L
Sbjct: 560 PLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHH----------ERGNPELE 609
Query: 714 QASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELD----RPDVPQ 769
Q + G PR + ++ +++ TE Y++ ++ ++ Y +D + +P
Sbjct: 610 QQARL----GDLSPR-----RRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD 660
Query: 770 GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKP 829
L+ + LFGN+ +L +FH FL+ELE C +P +A+ FL+ + +Y Y KN P
Sbjct: 661 VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP 720
Query: 830 RSDAL-MSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQEL----------- 877
R+ A+ +F Q+ L +L L YL P QR+ KY +LL+ L
Sbjct: 721 RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI 780
Query: 878 ------ARACGGPTQELSA-----LREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQ 926
A GP + + L++A +++ ++ + + A+ C ++ + G+
Sbjct: 781 DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK 840
Query: 927 LVRQDEFVVRT---GRHK---------SVRRIFLFEELLLFSKPR--HGPTGVDT-FAYK 971
L+ F V T R+K S R+I+LFE ++F K R G G+ +++K
Sbjct: 841 LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK 900
Query: 972 RSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 1031
++ K+ L + + S+ +FEI R + ++LQA+S I+ W ++IS LL Q
Sbjct: 901 KTMKLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQN 958
Query: 1032 HNKE 1035
+ K+
Sbjct: 959 NIKD 962
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 125 bits (313), Expect = 3e-28
Identities = 102/342 (29%), Positives = 161/342 (47%), Gaps = 29/342 (8%)
Query: 703 RRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL 762
R P A +P ++ P+ L + V+ E++ TER YV+ L+ +E+Y +
Sbjct: 85 RPPRAQWRVDSNGAPKTIADSATSPKLLY-VDRVVQEILETERTYVQDLKSIVEDYLDCI 143
Query: 763 -DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY 821
D+ +P G +R+ LFGN++ + F+ L++LE C P +A F+ +F +Y
Sbjct: 144 RDQTKLPLGTE-ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIY 201
Query: 822 ALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQE 876
Y N PRS A+++ FF+++Q+ L L L SYLLKP+QR+ KY LLL E
Sbjct: 202 TQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHE 261
Query: 877 LARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN-----LKEQ 924
+ T+ + +A + H ND+ + + IQ N L
Sbjct: 262 IENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSY 321
Query: 925 GQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTEC 984
G+LV + F R R K+ R +FLF++LLL +K R DTF YK +L L E
Sbjct: 322 GELVLEGTF--RIQRAKNERTLFLFDKLLLITKKRD-----DTFTYKAHILCGNLMLVEV 374
Query: 985 CGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
L F + F + + +QA S K+ W + L+
Sbjct: 375 IPKEPLSFSV-FHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 114 bits (284), Expect = 7e-25
Identities = 86/334 (25%), Positives = 161/334 (48%), Gaps = 20/334 (5%)
Query: 716 SPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR-PDVPQGLRGQ 774
+P P S+ RL V+ E++++E+ +V L++ ++ L+R P VP + GQ
Sbjct: 5677 APEFPGEAVSEDEYKARLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPIAVAGQ 5736
Query: 775 RAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDAL 834
+A +F N+ + FH F L+EL+ C VA F++++ F Y + + +++++
Sbjct: 5737 KAVIFRNVRDIGRFHSSF-LQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGRVQAESV 5794
Query: 835 MSSYGHTFFKDK--QQAL--GDHLD-----LASYLLKPIQRMGKYALLLQELARACGGPT 885
+ S F K ++AL GD L YL +P++R+ +Y LL+EL R
Sbjct: 5795 VVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNR 5854
Query: 886 QELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKS--- 942
Q + L +A ++V + + L + ++ L+ G+ +RQ F+V G +
Sbjct: 5855 QNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMP 5914
Query: 943 ----VRRIFLFEELLLFSKPRH-GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFR 997
R +FLF L+ KPR T ++ ++ K++ + L + + FE+W
Sbjct: 5915 WKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQE 5974
Query: 998 RRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 1031
R + ++LQA + IK +W +I + R A+
Sbjct: 5975 REDSVRKYLLQARTAIIKSSWVKEICGIQQRLAL 6008
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 114 bits (284), Expect = 7e-25
Identities = 86/334 (25%), Positives = 161/334 (48%), Gaps = 20/334 (5%)
Query: 716 SPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR-PDVPQGLRGQ 774
+P P S+ RL V+ E++++E+ +V L++ ++ L+R P VP + GQ
Sbjct: 5677 APEFPGEAVSEDEYKARLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPIAVAGQ 5736
Query: 775 RAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDAL 834
+A +F N+ + FH F L+EL+ C VA F++++ F Y + + +++++
Sbjct: 5737 KAVIFRNVRDIGRFHSSF-LQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGRVQAESV 5794
Query: 835 MSSYGHTFFKDK--QQAL--GDHLD-----LASYLLKPIQRMGKYALLLQELARACGGPT 885
+ S F K ++AL GD L YL +P++R+ +Y LL+EL R
Sbjct: 5795 VVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNR 5854
Query: 886 QELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKS--- 942
Q + L +A ++V + + L + ++ L+ G+ +RQ F+V G +
Sbjct: 5855 QNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMP 5914
Query: 943 ----VRRIFLFEELLLFSKPRH-GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFR 997
R +FLF L+ KPR T ++ ++ K++ + L + + FE+W
Sbjct: 5915 WKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQE 5974
Query: 998 RRKARDTFVLQASSLAIKQAWTADISHLLWRQAV 1031
R + ++LQA + IK +W +I + R A+
Sbjct: 5975 REDSVRKYLLQARTAIIKSSWVKEICGIQQRLAL 6008
>gi|55749621 pleckstrin homology domain containing, family G, member 3
[Homo sapiens]
Length = 1163
Score = 79.0 bits (193), Expect = 3e-14
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 26/227 (11%)
Query: 817 QFGMYALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYA 871
+F +Y Y N P S A ++ FF+D+Q+ L L L SYLLKP+QR+ KY
Sbjct: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
Query: 872 LLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN---- 920
LLLQE+A+ + +A + + ND+ + + IQ +N
Sbjct: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
Query: 921 -LKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADL 979
L G+LV + F R R ++ R FLF++ LL +K R D F YK + + L
Sbjct: 240 DLTTYGELVLEGTF--RVHRVRNERTFFLFDKTLLITKKRG-----DHFVYKGNIPCSSL 292
Query: 980 GLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
L E +S L F + + ++ + +QA ++ K+ WT I L+
Sbjct: 293 MLIESTRDS-LCFTV-THYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 77.0 bits (188), Expect = 1e-13
Identities = 61/164 (37%), Positives = 87/164 (53%), Gaps = 12/164 (7%)
Query: 722 PGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYF-PELDRPDVPQGLRGQRAHLFG 780
PGS+ P +RL+ V E+V TER YVR L +E+Y P LD + + Q LF
Sbjct: 95 PGSARP---SRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVE-QVGTLFA 150
Query: 781 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALM----- 835
N+E + +F L +LE + +A F++ F +Y LY N P S AL+
Sbjct: 151 NIEDIYEFSSEL-LEDLENSSS-AGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSL 208
Query: 836 SSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR 879
S + +++Q L L L S+LLKP+QR+ KY LLLQEL +
Sbjct: 209 SPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGK 252
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 74.3 bits (181), Expect = 6e-13
Identities = 79/289 (27%), Positives = 122/289 (42%), Gaps = 30/289 (10%)
Query: 705 PEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR 764
P A G A P + P R L VL E++ TER+YV L + + + +
Sbjct: 22 PRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQ 81
Query: 765 ---PDVPQGLRGQRAH-LFGNLEKLRDFHCHFFLRELEACTRHPPRVAY----AFLRHRV 816
V +GL + LF N+E + + H F L LE C P+ + FL+ +
Sbjct: 82 NVADSVEKGLTEENVKVLFSNIEDILEVHKDF-LAALEYCLHPEPQSQHELGNVFLKFKD 140
Query: 817 QFGMYALYSKNKPRSDALMSSYGHT----FFKDKQQALGDH----LDLASYLLKPIQRMG 868
+F +Y Y N ++ L+ F LG + L YLL PIQR+
Sbjct: 141 KFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRIC 200
Query: 869 KYALLLQELARACGGPTQE-------LSALREAQSLVHFQLRHGNDLLAMDAIQGC---- 917
KY LLL+ELA+ G + L A++ S ++ R L A++ +Q
Sbjct: 201 KYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGW 260
Query: 918 -DVNLKE-QGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTG 964
NL + QL+ Q + + + R FLF+ LL++ K + TG
Sbjct: 261 EGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTG 309
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 68.2 bits (165), Expect = 5e-11
Identities = 81/379 (21%), Positives = 154/379 (40%), Gaps = 50/379 (13%)
Query: 732 RLQLVLAEMVATEREYVRALEYTMENYF----PELDRPDVPQGLRGQRAHLFGNLEKLRD 787
+L + E++ TER YV L+ + ++ E +R P + + +F N+ +
Sbjct: 206 KLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNK---IFSNISSINA 262
Query: 788 FHCHFFLRELEACTRH---PPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTF-- 842
FH F L ELE + PR+ + MY Y K + L+ +
Sbjct: 263 FHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQ 322
Query: 843 FKD-----KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSL 897
FK ++Q + L L ++L+P+QR+ +Y +LL++ R + + + +++ +
Sbjct: 323 FKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEI 382
Query: 898 VHFQLRHGND----------LLAMDAIQGCDVNL-KEQGQLVRQDEFVVRTGRHKSV--R 944
+ H N LL + + G + ++ +L+++ + + R+ S R
Sbjct: 383 ISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQER 442
Query: 945 RIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT 1004
+FLF +LL+ P+ G F + + + + E N + F+ T
Sbjct: 443 YLFLFNNMLLYCVPKFSLVG-SKFTVRTRVGIDGMKIVE---TQNEEYPHTFQVSGKERT 498
Query: 1005 FVLQASSLAIKQAWTADIS---------HLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIA 1055
LQASS K+ W + H +R A+ +E+ + +G +A R
Sbjct: 499 LELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPR--- 555
Query: 1056 PSEEAINDRTVNYVLKCRE 1074
I D V +KC+E
Sbjct: 556 ----WIRDNEVTMCMKCKE 570
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 66.6 bits (161), Expect = 1e-10
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 30/185 (16%)
Query: 714 QASPTVPPPGS-----SDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVP 768
Q+S V P GS + R L + V+ E++ TER+Y+R LE +E + + VP
Sbjct: 761 QSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVP 820
Query: 769 Q-GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQF-GMYALYSK 826
G LFGN++ + ++L A V FL HR + G Y +Y +
Sbjct: 821 NIDFEG----LFGNMQMVIKVS-----KQLLAALEISDAVGPVFLGHRDELEGTYKIYCQ 871
Query: 827 NKPRSDALMSSY--GHTFFKDKQQALGD------------HLDLASYLLKPIQRMGKYAL 872
N + AL+ Y K Q +L D +++L S+L+KP+QR+ +Y L
Sbjct: 872 NHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPL 931
Query: 873 LLQEL 877
LL EL
Sbjct: 932 LLMEL 936
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 60.8 bits (146), Expect = 7e-09
Identities = 91/446 (20%), Positives = 174/446 (39%), Gaps = 92/446 (20%)
Query: 702 CRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-------------------------- 735
CR PE+ G P+ V S+PR+++R L
Sbjct: 43 CRPPESPG---PREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGT 99
Query: 736 ------VLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAH-------LFGNL 782
++ E++ TE+ YV L + +F EL + R +A +F N+
Sbjct: 100 QEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKT-----ARSSKAFPEDVVRVIFSNI 154
Query: 783 EKLRDFHCHFFLRELEACTRH---PPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSS-- 837
+ FH FFL EL+ PR+ + MY+ Y KN R+ L+++
Sbjct: 155 SSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWT 214
Query: 838 -----YGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 892
+ + + L L ++L+P+QR+ +Y LLL+E + + + +
Sbjct: 215 DKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQ 274
Query: 893 EAQSLVHFQLRHGNDLLA-MDAIQ---------GCDVNLKEQGQLVRQDEFVVRTGRHKS 942
+A ++ +H N + M+ +Q G + ++ + + ++ V++ ++
Sbjct: 275 KALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRN 334
Query: 943 ---VRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRR 999
R +FLF +LL+ PR G F + +A + + E + F F
Sbjct: 335 DPMERYLFLFNNMLLYCVPRVIQVGAQ-FQVRTRIDVAGMKVREL---MDAEFPHSFLVS 390
Query: 1000 KARDTFVLQASS----LAIKQAWTADISHLLWRQAVHNK-------EVRMAEMVSMGVGN 1048
+ T LQA S ++ QA+ A I + R +++ E+ S +G
Sbjct: 391 GKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGL 450
Query: 1049 KAFRDIAPSEEAINDRTVNYVLKCRE 1074
+A + + D+ V ++C+E
Sbjct: 451 RA-------PQWVRDKMVTMCMRCQE 469
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 59.7 bits (143), Expect = 2e-08
Identities = 74/292 (25%), Positives = 120/292 (41%), Gaps = 37/292 (12%)
Query: 712 LPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 771
L ++ P PP ++ ++ L E+ TE +Y L +++ L R PQ +
Sbjct: 177 LMRSEPVSMPPKMTE---YDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDI 233
Query: 772 RGQRAHLFGNLEKLRDFHCHFFLRELEAC-TRHPPRVAYAFLRHRVQFGMYALY------ 824
+F N+E L H HF EA T + F++++ +F +Y Y
Sbjct: 234 E----IIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVES 289
Query: 825 -SKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGG 883
SK+ R A + Q+A L L+ P+QR+ KY LLLQEL +
Sbjct: 290 ASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVK---- 345
Query: 884 PTQE----------LSALREAQSLVHFQLRHGNDLLAMD-----AIQGCDVNLKEQGQLV 928
TQE L A+R+ V+ +++ N+ L +I+ D +L G+
Sbjct: 346 HTQEAMEKENLRLALDAMRDLAQCVN-EVKRDNETLRQITNFQLSIENLDQSLAHYGRPK 404
Query: 929 RQDEFVVRT--GRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMAD 978
E + + R K R FL ++ LL K R + F SF++ D
Sbjct: 405 IDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRD 456
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 59.7 bits (143), Expect = 2e-08
Identities = 58/193 (30%), Positives = 89/193 (46%), Gaps = 35/193 (18%)
Query: 731 NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHC 790
++L+ V+ E++ TER YV+ L ME Y L + + + LFGNL ++ +F
Sbjct: 1039 DKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLT--QDELDVLFGNLTEMVEFQV 1096
Query: 791 HFFLRELEACTRHPP----------------RVAYAFLRHRVQFGMYALYSKNKPR-SDA 833
F L+ LE R P + +FL + +F +Y+ + + +
Sbjct: 1097 EF-LKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKV 1155
Query: 834 LMSSYGHTFFK---DKQQALGDHLD-LASYLLKPIQRMGKYALLLQELARACGGPTQELS 889
L+ + T FK D Q H L SYL+KPIQR+ KY LLL +EL
Sbjct: 1156 LVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL-----------RELF 1204
Query: 890 ALREAQSLVHFQL 902
AL +A+S H+ L
Sbjct: 1205 ALTDAESEEHYHL 1217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,967,105
Number of Sequences: 37866
Number of extensions: 2682106
Number of successful extensions: 11201
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 196
Number of HSP's that attempted gapping in prelim test: 10690
Number of HSP's gapped (non-prelim): 655
length of query: 1191
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1077
effective length of database: 13,930,794
effective search space: 15003465138
effective search space used: 15003465138
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.