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Search of human proteins with 54607135
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54607135 translocase of outer mitochondrial membrane 70
homolog A [Homo sapiens]
(608 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54607135 translocase of outer mitochondrial membrane 70 homol... 1213 0.0
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H... 93 6e-19
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H... 93 6e-19
gi|27262638 sperm associated antigen 1 [Homo sapiens] 89 2e-17
gi|27262636 sperm associated antigen 1 [Homo sapiens] 89 2e-17
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 88 3e-17
gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens] 82 1e-15
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 78 2e-14
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 77 4e-14
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 77 4e-14
gi|225735595 RNA polymerase II associated protein 3 isoform 3 [H... 75 1e-13
gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 73 9e-13
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 73 9e-13
gi|21361356 translocase of outer mitochondrial membrane 34 [Homo... 72 1e-12
gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens] 69 1e-11
gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens] 67 6e-11
gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens] 67 6e-11
gi|56181387 STIP1 homology and U-box containing protein 1 [Homo ... 64 3e-10
gi|29725607 smooth muscle cell associated protein-1 isoform 2 [H... 64 3e-10
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 63 7e-10
gi|19923193 heat shock 70kD protein binding protein [Homo sapiens] 62 1e-09
gi|4826932 peptidylprolyl isomerase D [Homo sapiens] 62 2e-09
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens] 62 2e-09
gi|89179321 smooth muscle cell associated protein-1 isoform 3 [H... 61 3e-09
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 59 1e-08
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 59 1e-08
gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens] 57 5e-08
gi|224809432 transmembrane and tetratricopeptide repeat containi... 57 5e-08
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 56 8e-08
gi|156627581 tetratricopeptide repeat domain 4 [Homo sapiens] 56 8e-08
>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
A [Homo sapiens]
Length = 608
Score = 1213 bits (3138), Expect = 0.0
Identities = 608/608 (100%), Positives = 608/608 (100%)
Query: 1 MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWS 60
MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWS
Sbjct: 1 MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWS 60
Query: 61 RQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNK 120
RQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNK
Sbjct: 61 RQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNK 120
Query: 121 GNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAV 180
GNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAV
Sbjct: 121 GNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAV 180
Query: 181 ELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKA 240
ELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKA
Sbjct: 181 ELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKA 240
Query: 241 KEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLK 300
KEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLK
Sbjct: 241 KEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLK 300
Query: 301 AKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKE 360
AKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKE
Sbjct: 301 AKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKE 360
Query: 361 ANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEA 420
ANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEA
Sbjct: 361 ANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEA 420
Query: 421 VADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYA 480
VADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYA
Sbjct: 421 VADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYA 480
Query: 481 LYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEI 540
LYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEI
Sbjct: 481 LYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEI 540
Query: 541 DNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKK 600
DNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKK
Sbjct: 541 DNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKK 600
Query: 601 YGLKPPTL 608
YGLKPPTL
Sbjct: 601 YGLKPPTL 608
>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
sapiens]
Length = 631
Score = 93.2 bits (230), Expect = 6e-19
Identities = 83/281 (29%), Positives = 121/281 (43%), Gaps = 37/281 (13%)
Query: 100 EGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNR 159
E G H+D +A K KGNKYFK GKY++AI CYT+ + P N L T NR
Sbjct: 122 EEDGIHVDSQ---KALVLKEKGNKYFKQGKYDEAIDCYTKGMDADP--YNPVLPT---NR 173
Query: 160 AAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-- 217
A+A+ +L+K+ DC AV LN Y KA RR A L +E +D V LE
Sbjct: 174 ASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPN 233
Query: 218 GFQ-----NQQSMLLADK-----------VLKLLGKEKAKEKYKNREPLMPSPQFIKSYF 261
F+ + S LA K + G+ K E +N++ + +F
Sbjct: 234 NFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFF 293
Query: 262 SSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEI 321
+ + +G + D L YLK ++Y E E +C++ I
Sbjct: 294 KEGKYERAIECYTRGIAA----DGANALLPANRAMAYLKIQKYEEAE------KDCTQAI 343
Query: 322 DAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEAN 362
+G Y ++A R T +G N AK D + V+ L+ N
Sbjct: 344 LLDGSY-SKAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383
Score = 75.1 bits (183), Expect = 2e-13
Identities = 44/121 (36%), Positives = 68/121 (56%), Gaps = 6/121 (4%)
Query: 113 RAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEV 172
+A + K++GN +FK GKYE+AI+CYT I+ + NRA A+ ++QK++E
Sbjct: 281 QAISEKDRGNGFFKEGKYERAIECYTRGIAADGAN-----ALLPANRAMAYLKIQKYEEA 335
Query: 173 AQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVL 232
+DCT+A+ L+ Y KA RR A L E +D V +LE N+Q++ K+
Sbjct: 336 EKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEP-GNKQAVTELSKIK 394
Query: 233 K 233
K
Sbjct: 395 K 395
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/286 (19%), Positives = 108/286 (37%), Gaps = 31/286 (10%)
Query: 306 EEENYDKIISECSKEIDAEGKYMAEALLLR--ATFYLLIGNANAAKPDLDKVISLKEANV 363
++ ++ + E E D +AL+L+ Y G + A K + N
Sbjct: 108 DDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNP 167
Query: 364 KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423
L N R S Y + ++ ++ D N+A ++ Y RG + L ++EEA D
Sbjct: 168 VLPTN----RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKD 223
Query: 424 FDECIRLRPE-----SALAQAQKCFALYRQAY----------TGNNSSQIQAAMKGFEEV 468
++ + L P + L + + A +Y T QI+A + +
Sbjct: 224 YERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI 283
Query: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLD 528
+K G + + ++ +A E Y + I + NA ++ + L+ Q +
Sbjct: 284 SEK----DRGNGFFKEG-----KYERAIECYTRGIAADGANALLPANRAMAYLK-IQKYE 333
Query: 529 RGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574
+ ++AI +D A+ GT G + +A F + L
Sbjct: 334 EAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLL 379
>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
sapiens]
Length = 665
Score = 93.2 bits (230), Expect = 6e-19
Identities = 83/281 (29%), Positives = 121/281 (43%), Gaps = 37/281 (13%)
Query: 100 EGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNR 159
E G H+D +A K KGNKYFK GKY++AI CYT+ + P N L T NR
Sbjct: 122 EEDGIHVDSQ---KALVLKEKGNKYFKQGKYDEAIDCYTKGMDADP--YNPVLPT---NR 173
Query: 160 AAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-- 217
A+A+ +L+K+ DC AV LN Y KA RR A L +E +D V LE
Sbjct: 174 ASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPN 233
Query: 218 GFQ-----NQQSMLLADK-----------VLKLLGKEKAKEKYKNREPLMPSPQFIKSYF 261
F+ + S LA K + G+ K E +N++ + +F
Sbjct: 234 NFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFF 293
Query: 262 SSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEI 321
+ + +G + D L YLK ++Y E E +C++ I
Sbjct: 294 KEGKYERAIECYTRGIAA----DGANALLPANRAMAYLKIQKYEEAE------KDCTQAI 343
Query: 322 DAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEAN 362
+G Y ++A R T +G N AK D + V+ L+ N
Sbjct: 344 LLDGSY-SKAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383
Score = 75.5 bits (184), Expect = 1e-13
Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 6/123 (4%)
Query: 113 RAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEV 172
+A + K++GN +FK GKYE+AI+CYT I+ + NRA A+ ++QK++E
Sbjct: 281 QAISEKDRGNGFFKEGKYERAIECYTRGIAADGAN-----ALLPANRAMAYLKIQKYEEA 335
Query: 173 AQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVL 232
+DCT+A+ L+ Y KA RR A L E +D V +LE N+Q++ K+
Sbjct: 336 EKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEP-GNKQAVTELSKIK 394
Query: 233 KLL 235
K L
Sbjct: 395 KEL 397
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/286 (19%), Positives = 108/286 (37%), Gaps = 31/286 (10%)
Query: 306 EEENYDKIISECSKEIDAEGKYMAEALLLR--ATFYLLIGNANAAKPDLDKVISLKEANV 363
++ ++ + E E D +AL+L+ Y G + A K + N
Sbjct: 108 DDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNP 167
Query: 364 KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423
L N R S Y + ++ ++ D N+A ++ Y RG + L ++EEA D
Sbjct: 168 VLPTN----RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKD 223
Query: 424 FDECIRLRPE-----SALAQAQKCFALYRQAY----------TGNNSSQIQAAMKGFEEV 468
++ + L P + L + + A +Y T QI+A + +
Sbjct: 224 YERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI 283
Query: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLD 528
+K G + + ++ +A E Y + I + NA ++ + L+ Q +
Sbjct: 284 SEK----DRGNGFFKEG-----KYERAIECYTRGIAADGANALLPANRAMAYLK-IQKYE 333
Query: 529 RGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574
+ ++AI +D A+ GT G + +A F + L
Sbjct: 334 EAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLL 379
>gi|27262638 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 88.6 bits (218), Expect = 2e-17
Identities = 86/344 (25%), Positives = 149/344 (43%), Gaps = 25/344 (7%)
Query: 61 RQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNK 120
R R RG+ +G + S R+ A+ +GHP G + K++
Sbjct: 398 RPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGG------QGAENPAGLKSQ 451
Query: 121 GNKYFKAGKYEQAIQCYTEAISLCP---TEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCT 177
GN+ F++G++ +A Y+ AI+L +E DLS Y NRAA + + QDC
Sbjct: 452 GNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCN 511
Query: 178 KAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-GFQ-NQQSMLLADKVLKLL 235
+A+EL+P +K L RRA A+E L+ + D V ++ G Q S+ ++L L
Sbjct: 512 RALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRILMEL 571
Query: 236 GKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKEN 295
+EK + P +P+ ++++ ++ M+ + D ++ + K
Sbjct: 572 DGPNWREKL-SPIPAVPASVPLQAWHP-------AKEMISKQAGDSSSHRQQGITDEKTF 623
Query: 296 SGYL-KAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDK 354
+ Q + ++NY +S+ S+ + K A RA YL + AK D D+
Sbjct: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKECA-IYTNRALCYLKLCQFEEAKQDCDQ 682
Query: 355 VISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDP 398
+ L + NVK A +R + + S D N +DP
Sbjct: 683 ALQLADGNVK----AFYRRALAHKGLKNYQKSLIDLNKVILLDP 722
Score = 80.5 bits (197), Expect = 4e-15
Identities = 48/129 (37%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 114 AQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVA 173
A K KGN+ F +G YE+A+ YT +IS PT Y NRA A +LQ W
Sbjct: 209 ATREKEKGNEAFNSGDYEEAVMYYTRSISALPTV------VAYNNRAQAEIKLQNWNSAF 262
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLK 233
QDC K +EL P VKAL RRA ++ + +E ED++ V +E + L++
Sbjct: 263 QDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERD 322
Query: 234 LLGKEKAKE 242
L E A E
Sbjct: 323 LKNSEAASE 331
Score = 62.4 bits (150), Expect = 1e-09
Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 5/134 (3%)
Query: 115 QAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQ 174
+A K +GN+ Y+ A+ Y+E + + E Y NRA + +L +++E Q
Sbjct: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKE-----CAIYTNRALCYLKLCQFEEAKQ 678
Query: 175 DCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKL 234
DC +A++L VKA +RRA AH+ L N ++ L D+ V +L+ + M L + L
Sbjct: 679 DCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLL 738
Query: 235 LGKEKAKEKYKNRE 248
K+K K +E
Sbjct: 739 NLKDKTAPFNKEKE 752
Score = 48.1 bits (113), Expect = 2e-05
Identities = 48/184 (26%), Positives = 76/184 (41%), Gaps = 22/184 (11%)
Query: 410 LKILLDQVEEAVADFDECIRLRPE---SALAQAQKCFALYRQAYTGN---NSSQIQAAMK 463
LKI D E+ V D ++ + L + +K F R+ GN NS + A+
Sbjct: 171 LKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVM 230
Query: 464 GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDN-------ATTYVHK 516
+ I P Y AQA Q + A + +K ++LEP N ATTY H+
Sbjct: 231 YYTRSISALPTVV-AYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQ 289
Query: 517 GLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAK 576
L+ E +SK ++++ D A +T+ +E N E A + K +
Sbjct: 290 NKLR--------EATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVI 341
Query: 577 SEME 580
E+E
Sbjct: 342 QEIE 345
Score = 43.5 bits (101), Expect = 6e-04
Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 26/164 (15%)
Query: 241 KEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEK---SDEDKDKEGEALEVKENSG 297
KE K E KS+ S I + + + EK + +K+K EA NSG
Sbjct: 168 KECLKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAF----NSG 223
Query: 298 -YLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVI 356
Y +A Y Y + IS + + AE + + N N+A D +KV+
Sbjct: 224 DYEEAVMY-----YTRSISALPTVVAYNNRAQAE---------IKLQNWNSAFQDCEKVL 269
Query: 357 SLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQN 400
L+ NVK AL++R + Y Q + +T+D + D++P N
Sbjct: 270 ELEPGNVK----ALLRRATTYKHQNKLREATEDLSKVLDVEPDN 309
>gi|27262636 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 88.6 bits (218), Expect = 2e-17
Identities = 86/344 (25%), Positives = 149/344 (43%), Gaps = 25/344 (7%)
Query: 61 RQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNK 120
R R RG+ +G + S R+ A+ +GHP G + K++
Sbjct: 398 RPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGG------QGAENPAGLKSQ 451
Query: 121 GNKYFKAGKYEQAIQCYTEAISLCP---TEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCT 177
GN+ F++G++ +A Y+ AI+L +E DLS Y NRAA + + QDC
Sbjct: 452 GNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCN 511
Query: 178 KAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-GFQ-NQQSMLLADKVLKLL 235
+A+EL+P +K L RRA A+E L+ + D V ++ G Q S+ ++L L
Sbjct: 512 RALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRILMEL 571
Query: 236 GKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKEN 295
+EK + P +P+ ++++ ++ M+ + D ++ + K
Sbjct: 572 DGPNWREKL-SPIPAVPASVPLQAWHP-------AKEMISKQAGDSSSHRQQGITDEKTF 623
Query: 296 SGYL-KAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDK 354
+ Q + ++NY +S+ S+ + K A RA YL + AK D D+
Sbjct: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKECA-IYTNRALCYLKLCQFEEAKQDCDQ 682
Query: 355 VISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDP 398
+ L + NVK A +R + + S D N +DP
Sbjct: 683 ALQLADGNVK----AFYRRALAHKGLKNYQKSLIDLNKVILLDP 722
Score = 80.5 bits (197), Expect = 4e-15
Identities = 48/129 (37%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 114 AQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVA 173
A K KGN+ F +G YE+A+ YT +IS PT Y NRA A +LQ W
Sbjct: 209 ATREKEKGNEAFNSGDYEEAVMYYTRSISALPTV------VAYNNRAQAEIKLQNWNSAF 262
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLK 233
QDC K +EL P VKAL RRA ++ + +E ED++ V +E + L++
Sbjct: 263 QDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERD 322
Query: 234 LLGKEKAKE 242
L E A E
Sbjct: 323 LKNSEAASE 331
Score = 62.4 bits (150), Expect = 1e-09
Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 5/134 (3%)
Query: 115 QAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQ 174
+A K +GN+ Y+ A+ Y+E + + E Y NRA + +L +++E Q
Sbjct: 624 KALKEEGNQCVNDKNYKDALSKYSECLKINNKE-----CAIYTNRALCYLKLCQFEEAKQ 678
Query: 175 DCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKL 234
DC +A++L VKA +RRA AH+ L N ++ L D+ V +L+ + M L + L
Sbjct: 679 DCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLL 738
Query: 235 LGKEKAKEKYKNRE 248
K+K K +E
Sbjct: 739 NLKDKTAPFNKEKE 752
Score = 48.1 bits (113), Expect = 2e-05
Identities = 48/184 (26%), Positives = 76/184 (41%), Gaps = 22/184 (11%)
Query: 410 LKILLDQVEEAVADFDECIRLRPE---SALAQAQKCFALYRQAYTGN---NSSQIQAAMK 463
LKI D E+ V D ++ + L + +K F R+ GN NS + A+
Sbjct: 171 LKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVM 230
Query: 464 GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDN-------ATTYVHK 516
+ I P Y AQA Q + A + +K ++LEP N ATTY H+
Sbjct: 231 YYTRSISALPTVV-AYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQ 289
Query: 517 GLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAK 576
L+ E +SK ++++ D A +T+ +E N E A + K +
Sbjct: 290 NKLR--------EATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVI 341
Query: 577 SEME 580
E+E
Sbjct: 342 QEIE 345
Score = 43.5 bits (101), Expect = 6e-04
Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 26/164 (15%)
Query: 241 KEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEK---SDEDKDKEGEALEVKENSG 297
KE K E KS+ S I + + + EK + +K+K EA NSG
Sbjct: 168 KECLKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAF----NSG 223
Query: 298 -YLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVI 356
Y +A Y Y + IS + + AE + + N N+A D +KV+
Sbjct: 224 DYEEAVMY-----YTRSISALPTVVAYNNRAQAE---------IKLQNWNSAFQDCEKVL 269
Query: 357 SLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQN 400
L+ NVK AL++R + Y Q + +T+D + D++P N
Sbjct: 270 ELEPGNVK----ALLRRATTYKHQNKLREATEDLSKVLDVEPDN 309
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 87.8 bits (216), Expect = 3e-17
Identities = 109/493 (22%), Positives = 193/493 (39%), Gaps = 91/493 (18%)
Query: 111 LDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWK 170
+++ K KGNK G + A+QCY+EAI L P Y NR+AA+ + ++
Sbjct: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHN-----HVLYSNRSAAYAKKGDYQ 55
Query: 171 EVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKEC--------LEDVTAVCILEGFQNQ 222
+ +D K V+L P + K R+A A E L+ +E + + EG QN
Sbjct: 56 KAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNM 115
Query: 223 QSMLLADKVLKLLGKEKAKEKYKN---REPLMPSPQF----------------------I 257
++ L K + +K ++ L+ P + I
Sbjct: 116 EARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRI 175
Query: 258 KSYFSSF----------TDDIISQP-------MLKGEKSDED-KDKEGEALEVKE--NSG 297
+ S ++I + P K E +ED + + +AL+ KE N
Sbjct: 176 MTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDA 235
Query: 298 YLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVIS 357
Y K ++YDK +KE+D + +A Y G+ N + +K I
Sbjct: 236 YKKKDFDTALKHYDK-----AKELDPTN---MTYITNQAAVYFEKGDYNKCRELCEKAIE 287
Query: 358 LKEAN---VKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILL 414
+ N + A A + G+ Y ++++ + +N + H +
Sbjct: 288 VGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSL--------AEHRTPDVLKKC 339
Query: 415 DQVEEAVADFDECIRLRPESALAQAQK---CFALYRQAYTGNNSSQIQAAMKGFEEVIKK 471
Q E+ + + + + P+ AL + K CF AMK + E IK+
Sbjct: 340 QQAEKILKEQERLAYINPDLALEEKNKGNECF----------QKGDYPQAMKHYTEAIKR 389
Query: 472 FPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGL 531
P+ A+ Y+ A T +F A + ++CI LEP Y K L+ +D + +
Sbjct: 390 NPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKA-AALEAMKDYTKAM 448
Query: 532 ELISKAIEIDNKC 544
++ KA+++D+ C
Sbjct: 449 DVYQKALDLDSSC 461
>gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]
Length = 292
Score = 82.0 bits (201), Expect = 1e-15
Identities = 38/96 (39%), Positives = 59/96 (61%)
Query: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCT 177
K +GN+ FK G Y +A Y+ A+ +CP+ + S + NRAAA + K + DC+
Sbjct: 120 KEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCS 179
Query: 178 KAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAV 213
KA++LNP Y++A+ RRA+ +EK D E LED ++
Sbjct: 180 KAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSI 215
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 78.2 bits (191), Expect = 2e-14
Identities = 111/493 (22%), Positives = 190/493 (38%), Gaps = 76/493 (15%)
Query: 133 AIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 192
AI YT+AI PT+ ++ Y R +E K + D +K + +PK AL +
Sbjct: 1004 AILNYTQAIKSTPTDADI-----YFRRGEMYEITNKVLAI-DDFSKCIFYDPKRTDALLK 1057
Query: 193 RAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAK-------EKYK 245
R + + +N +ED TA+ ++ +Q S +L + + AK E K
Sbjct: 1058 RGLFYCENENWFAAIEDFTALLNID---HQNSQARGQYLLMMKYYDLAKFTIYQIAEMDK 1114
Query: 246 NREPLMPSPQFIKSYFSSFTDD-------------------IISQPMLKGEKSDE----- 281
L P Q + F D ++++ +K +++ E
Sbjct: 1115 GLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVL 1174
Query: 282 --------DKDKEGEALEVKENSGYLKAKQYMEEEN----YDKIISECSKEIDAEGKYMA 329
DK +A + + Y YMEE N Y I++ + I + K
Sbjct: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMD-KNSY 1233
Query: 330 EALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQD 389
A RA Y I A D ++ L +A ++ N + RG +Y++ Q + +D
Sbjct: 1234 TAFYNRALCYTKIRELQMALTDYG-IVLLLDATETVKLNTFLNRGLIYVELGQYGFALED 1292
Query: 390 FNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQA 449
F AA I N + H +++ EEAV F +++ P CF A
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP---------CFL---DA 1340
Query: 450 YTGNNSSQIQ--------AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDK 501
Y G +S ++ A K F + + P + + L Q +F KA +
Sbjct: 1341 YVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTI 1400
Query: 502 CIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNM 561
ID +P N Y + ++ LQ + ++ I+ A++I +F G I G+
Sbjct: 1401 AIDTDPKNYLAYEGRAVVCLQMGNNF-AAMQDINAAMKISTTAEF-LTNRGVIHEFMGHK 1458
Query: 562 EKAIDMFNKAINL 574
+ A+ + AI L
Sbjct: 1459 QNAMKDYQDAITL 1471
Score = 51.6 bits (122), Expect = 2e-06
Identities = 73/327 (22%), Positives = 130/327 (39%), Gaps = 53/327 (16%)
Query: 124 YFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELN 183
+ + ++E+A+ +T A+ + P +D N + + K+ +D KA+ +N
Sbjct: 1314 HHRINEFEEAVNFFTWALKINPCF--LDAYVGRGNSYMEYGHDEATKQAQKDFLKALHIN 1371
Query: 184 PKYVKAL------------FRRAKAHEKL----DNKKECLEDVTAVCILEGFQNQQSMLL 227
P Y+KA F++A H + D K + AV L+ N +M
Sbjct: 1372 PAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQD 1431
Query: 228 ADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKD-KE 286
+ +K+ E NR +I + M G K + KD ++
Sbjct: 1432 INAAMKI---STTAEFLTNR-------------------GVIHEFM--GHKQNAMKDYQD 1467
Query: 287 GEALEVKENSGYLKAKQ-YMEEENYDKIISECSKEI--DAEGKYMAEALLLRATFYLLIG 343
L K + Y A Y + + SK + D E +Y+ L+ RA ++
Sbjct: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYV---LMNRAITNTILK 1524
Query: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403
AK D VI + A R Y +Q L+ +D N A + P +A V
Sbjct: 1525 KYEEAKEDFANVIE----SCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580
Query: 404 YHHRGQLKILLDQVEEAVADFDECIRL 430
Y+ R +++ + +EEA+AD+++ + L
Sbjct: 1581 YNFRAKVRGKIGLIEEAMADYNQALDL 1607
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/225 (22%), Positives = 94/225 (41%), Gaps = 20/225 (8%)
Query: 295 NSGYLKAK-----QYMEEENYDKIISECSKEIDAEGK-YMAEALLLRATFYLLIGNANAA 348
N Y+KA+ + + K + + ID + K Y+A RA L +GN AA
Sbjct: 1371 NPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG--RAVVCLQMGNNFAA 1428
Query: 349 KPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRG 408
D++ + + A L RG ++ + +D+ A ++P+ + Y + G
Sbjct: 1429 MQDINAAMKISTT-----AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAG 1483
Query: 409 QLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEV 468
+ Q +A F + ++ PE+ + L +A T + + A + F V
Sbjct: 1484 NIYFHHRQFSQASDYFSKALKFDPENE-------YVLMNRAITNTILKKYEEAKEDFANV 1536
Query: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTY 513
I+ P A Y A +Q+ A+E +K + L+P++A Y
Sbjct: 1537 IESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Score = 40.8 bits (94), Expect = 0.004
Identities = 49/244 (20%), Positives = 92/244 (37%), Gaps = 27/244 (11%)
Query: 364 KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423
K A A +RG++Y + + + D ++P + Y HR + + D++ EA+ D
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 424 FDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYA 483
+ + + A K +YR I A+ + + IK P A+ Y
Sbjct: 974 LNYIHKYNKNNTEAYLSKA-EIYR------GKKDITLAILNYTQAIKSTPTDADIYFRRG 1026
Query: 484 QALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNK 543
+ + D+ + KCI +P + +GL + ++ +E + + ID++
Sbjct: 1027 EMYEITNKVLAIDD-FSKCIFYDPKRTDALLKRGLFYCE-NENWFAAIEDFTALLNIDHQ 1084
Query: 544 CDFA----------YETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHA 593
A Y+ Q M+K + S M+ A +YS C+
Sbjct: 1085 NSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSEL--------SPMQQALIYSFCENHDK 1136
Query: 594 QTEV 597
EV
Sbjct: 1137 AIEV 1140
Score = 40.4 bits (93), Expect = 0.005
Identities = 38/192 (19%), Positives = 75/192 (39%), Gaps = 15/192 (7%)
Query: 330 EALLLRATFYLLIGNANAAKP---DLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLS 386
+A + R Y+ G+ A K D K + + A +K R I G Q + +
Sbjct: 1339 DAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR----ISFGYNLQAQGKFQKA 1394
Query: 387 TQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALY 446
F +A D DP+N Y R + + + A+ D + +++ + L
Sbjct: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEF--------LT 1446
Query: 447 RQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506
+ Q AMK +++ I P+ + Y +QF +A + + K + +
Sbjct: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 507 PDNATTYVHKGL 518
P+N +++ +
Sbjct: 1507 PENEYVLMNRAI 1518
Score = 38.1 bits (87), Expect = 0.024
Identities = 83/403 (20%), Positives = 149/403 (36%), Gaps = 58/403 (14%)
Query: 106 LDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQ 165
LD + N+G Y + G+Y A++ + +A + T ++ +T A +
Sbjct: 1262 LDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHAT-----AMCHHR 1316
Query: 166 LQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSM 225
+ +++E T A+++NP ++ A R ++ + + ++ T Q Q+
Sbjct: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGH-----DEATK-------QAQKDF 1364
Query: 226 LLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDK 285
L A + K + Y L +F K++ + FT I + P
Sbjct: 1365 LKALHINPAYIKARISFGYN----LQAQGKFQKAW-NHFTIAIDTDPK-------NYLAY 1412
Query: 286 EGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYM--AEALLLRATFYLLIG 343
EG A+ + A Q +I+A K AE L R + +G
Sbjct: 1413 EGRAVVCLQMGNNFAAMQ----------------DINAAMKISTTAEFLTNRGVIHEFMG 1456
Query: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403
+ A D I+L NA G++Y +Q ++ F+ A DP+N V
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLAYFNA----GNIYFHHRQFSQASDYFSKALKFDPENEYV 1512
Query: 404 YHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMK 463
+R +L + EEA DF I P A + +A+ Q + A +
Sbjct: 1513 LMNRAITNTILKKYEEAKEDFANVIESCPFWAA-------VYFNRAHFYYCLKQYELAEE 1565
Query: 464 GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506
+ + P A Y A+ +A Y++ +DLE
Sbjct: 1566 DLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
Score = 37.0 bits (84), Expect = 0.053
Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 5/91 (5%)
Query: 129 KYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVK 188
KYE+A + + I CP V Y NRA + L++++ +D KA+ L P
Sbjct: 1525 KYEEAKEDFANVIESCPFWAAV-----YFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
Query: 189 ALFRRAKAHEKLDNKKECLEDVTAVCILEGF 219
RAK K+ +E + D LE +
Sbjct: 1580 VYNFRAKVRGKIGLIEEAMADYNQALDLEDY 1610
Score = 32.3 bits (72), Expect = 1.3
Identities = 23/100 (23%), Positives = 44/100 (44%), Gaps = 5/100 (5%)
Query: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTF----YQNRAAAFEQLQKWKEVA 173
K K N Y ++ ++ I+ Y + + E N D + + Y R A + +L K +
Sbjct: 879 KLKLNDYVESDLPQEVIKYYESEVKILTEEIN-DKTKYPAFAYCRRGAIYRKLGKLQSAM 937
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAV 213
D + + L P ++ A + R + D E L+D+ +
Sbjct: 938 NDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYI 977
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 77.4 bits (189), Expect = 4e-14
Identities = 111/493 (22%), Positives = 190/493 (38%), Gaps = 76/493 (15%)
Query: 133 AIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 192
AI YT+AI PT+ ++ Y R +E K + D +K + +PK AL +
Sbjct: 1004 AILNYTQAIKSTPTDADI-----YFRRGEMYEITNKVLAI-DDFSKCIFYDPKRTDALLK 1057
Query: 193 RAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAK-------EKYK 245
R + + +N +ED TA+ ++ +Q S +L + + AK E K
Sbjct: 1058 RGLFYCENENWFAAIEDFTALLNID---HQNSQARGQYLLMMKYYDLAKFTIYQIAEMDK 1114
Query: 246 NREPLMPSPQFIKSYFSSFTDD-------------------IISQPMLKGEKSDE----- 281
L P Q + F D ++++ +K +++ E
Sbjct: 1115 GLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVL 1174
Query: 282 --------DKDKEGEALEVKENSGYLKAKQYMEEEN----YDKIISECSKEIDAEGKYMA 329
DK +A + + Y YMEE N Y I++ + I + K
Sbjct: 1175 KKALDASSHSDKGPDATTISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMD-KNSY 1233
Query: 330 EALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQD 389
A RA Y I A D ++ L +A ++ N + RG +Y++ Q + +D
Sbjct: 1234 IAFYNRALCYTKIRELQMALTDYG-IVLLLDATETVKLNTFLNRGLIYVELGQYGFALED 1292
Query: 390 FNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQA 449
F AA I N + H +++ EEAV F +++ P CF A
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP---------CFL---DA 1340
Query: 450 YTGNNSSQIQ--------AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDK 501
Y G +S ++ A K F + + P + + L Q +F KA +
Sbjct: 1341 YVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTI 1400
Query: 502 CIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNM 561
ID +P N Y + ++ LQ + ++ I+ A++I +F G I G+
Sbjct: 1401 AIDTDPKNYLAYEGRAVVCLQMGNNF-AAMQDINAAMKISTTAEF-LTNRGVIHEFMGHK 1458
Query: 562 EKAIDMFNKAINL 574
+ A+ + AI L
Sbjct: 1459 QNAMKDYQDAITL 1471
Score = 51.6 bits (122), Expect = 2e-06
Identities = 73/327 (22%), Positives = 130/327 (39%), Gaps = 53/327 (16%)
Query: 124 YFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELN 183
+ + ++E+A+ +T A+ + P +D N + + K+ +D KA+ +N
Sbjct: 1314 HHRINEFEEAVNFFTWALKINPCF--LDAYVGRGNSYMEYGHDEATKQAQKDFLKALHIN 1371
Query: 184 PKYVKAL------------FRRAKAHEKL----DNKKECLEDVTAVCILEGFQNQQSMLL 227
P Y+KA F++A H + D K + AV L+ N +M
Sbjct: 1372 PAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQD 1431
Query: 228 ADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKD-KE 286
+ +K+ E NR +I + M G K + KD ++
Sbjct: 1432 INAAMKI---STTAEFLTNR-------------------GVIHEFM--GHKQNAMKDYQD 1467
Query: 287 GEALEVKENSGYLKAKQ-YMEEENYDKIISECSKEI--DAEGKYMAEALLLRATFYLLIG 343
L K + Y A Y + + SK + D E +Y+ L+ RA ++
Sbjct: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYV---LMNRAITNTILK 1524
Query: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403
AK D VI + A R Y +Q L+ +D N A + P +A V
Sbjct: 1525 KYEEAKEDFANVIE----SCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580
Query: 404 YHHRGQLKILLDQVEEAVADFDECIRL 430
Y+ R +++ + +EEA+AD+++ + L
Sbjct: 1581 YNFRAKVRGKIGLIEEAMADYNQALDL 1607
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/225 (22%), Positives = 94/225 (41%), Gaps = 20/225 (8%)
Query: 295 NSGYLKAK-----QYMEEENYDKIISECSKEIDAEGK-YMAEALLLRATFYLLIGNANAA 348
N Y+KA+ + + K + + ID + K Y+A RA L +GN AA
Sbjct: 1371 NPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG--RAVVCLQMGNNFAA 1428
Query: 349 KPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRG 408
D++ + + A L RG ++ + +D+ A ++P+ + Y + G
Sbjct: 1429 MQDINAAMKISTT-----AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAG 1483
Query: 409 QLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEV 468
+ Q +A F + ++ PE+ + L +A T + + A + F V
Sbjct: 1484 NIYFHHRQFSQASDYFSKALKFDPENE-------YVLMNRAITNTILKKYEEAKEDFANV 1536
Query: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTY 513
I+ P A Y A +Q+ A+E +K + L+P++A Y
Sbjct: 1537 IESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Score = 40.8 bits (94), Expect = 0.004
Identities = 49/244 (20%), Positives = 92/244 (37%), Gaps = 27/244 (11%)
Query: 364 KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423
K A A +RG++Y + + + D ++P + Y HR + + D++ EA+ D
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 424 FDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYA 483
+ + + A K +YR I A+ + + IK P A+ Y
Sbjct: 974 LNYIHKYNKNNTEAYLSKA-EIYR------GKKDITLAILNYTQAIKSTPTDADIYFRRG 1026
Query: 484 QALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNK 543
+ + D+ + KCI +P + +GL + ++ +E + + ID++
Sbjct: 1027 EMYEITNKVLAIDD-FSKCIFYDPKRTDALLKRGLFYCE-NENWFAAIEDFTALLNIDHQ 1084
Query: 544 CDFA----------YETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHA 593
A Y+ Q M+K + S M+ A +YS C+
Sbjct: 1085 NSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSEL--------SPMQQALIYSFCENHDK 1136
Query: 594 QTEV 597
EV
Sbjct: 1137 AIEV 1140
Score = 40.4 bits (93), Expect = 0.005
Identities = 38/192 (19%), Positives = 75/192 (39%), Gaps = 15/192 (7%)
Query: 330 EALLLRATFYLLIGNANAAKP---DLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLS 386
+A + R Y+ G+ A K D K + + A +K R I G Q + +
Sbjct: 1339 DAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR----ISFGYNLQAQGKFQKA 1394
Query: 387 TQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALY 446
F +A D DP+N Y R + + + A+ D + +++ + L
Sbjct: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEF--------LT 1446
Query: 447 RQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506
+ Q AMK +++ I P+ + Y +QF +A + + K + +
Sbjct: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 507 PDNATTYVHKGL 518
P+N +++ +
Sbjct: 1507 PENEYVLMNRAI 1518
Score = 38.1 bits (87), Expect = 0.024
Identities = 83/403 (20%), Positives = 149/403 (36%), Gaps = 58/403 (14%)
Query: 106 LDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQ 165
LD + N+G Y + G+Y A++ + +A + T ++ +T A +
Sbjct: 1262 LDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHAT-----AMCHHR 1316
Query: 166 LQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSM 225
+ +++E T A+++NP ++ A R ++ + + ++ T Q Q+
Sbjct: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGH-----DEATK-------QAQKDF 1364
Query: 226 LLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDK 285
L A + K + Y L +F K++ + FT I + P
Sbjct: 1365 LKALHINPAYIKARISFGYN----LQAQGKFQKAW-NHFTIAIDTDPK-------NYLAY 1412
Query: 286 EGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYM--AEALLLRATFYLLIG 343
EG A+ + A Q +I+A K AE L R + +G
Sbjct: 1413 EGRAVVCLQMGNNFAAMQ----------------DINAAMKISTTAEFLTNRGVIHEFMG 1456
Query: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403
+ A D I+L NA G++Y +Q ++ F+ A DP+N V
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLAYFNA----GNIYFHHRQFSQASDYFSKALKFDPENEYV 1512
Query: 404 YHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMK 463
+R +L + EEA DF I P A + +A+ Q + A +
Sbjct: 1513 LMNRAITNTILKKYEEAKEDFANVIESCPFWAA-------VYFNRAHFYYCLKQYELAEE 1565
Query: 464 GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506
+ + P A Y A+ +A Y++ +DLE
Sbjct: 1566 DLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
Score = 37.0 bits (84), Expect = 0.053
Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 5/91 (5%)
Query: 129 KYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVK 188
KYE+A + + I CP V Y NRA + L++++ +D KA+ L P
Sbjct: 1525 KYEEAKEDFANVIESCPFWAAV-----YFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
Query: 189 ALFRRAKAHEKLDNKKECLEDVTAVCILEGF 219
RAK K+ +E + D LE +
Sbjct: 1580 VYNFRAKVRGKIGLIEEAMADYNQALDLEDY 1610
Score = 32.3 bits (72), Expect = 1.3
Identities = 23/100 (23%), Positives = 44/100 (44%), Gaps = 5/100 (5%)
Query: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTF----YQNRAAAFEQLQKWKEVA 173
K K N Y ++ ++ I+ Y + + E N D + + Y R A + +L K +
Sbjct: 879 KLKLNDYVESDLPQEVIKYYESEVKILTEEIN-DKTKYPAFAYCRRGAIYRKLGKLQSAM 937
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAV 213
D + + L P ++ A + R + D E L+D+ +
Sbjct: 938 NDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYI 977
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 77.4 bits (189), Expect = 4e-14
Identities = 111/493 (22%), Positives = 190/493 (38%), Gaps = 76/493 (15%)
Query: 133 AIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 192
AI YT+AI PT+ ++ Y R +E K + D +K + +PK AL +
Sbjct: 1004 AILNYTQAIKSTPTDADI-----YFRRGEMYEITNKVLAI-DDFSKCIFYDPKRTDALLK 1057
Query: 193 RAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAK-------EKYK 245
R + + +N +ED TA+ ++ +Q S +L + + AK E K
Sbjct: 1058 RGLFYCENENWFAAIEDFTALLNID---HQNSQARGQYLLMMKYYDLAKFTIYQIAEMDK 1114
Query: 246 NREPLMPSPQFIKSYFSSFTDD-------------------IISQPMLKGEKSDE----- 281
L P Q + F D ++++ +K +++ E
Sbjct: 1115 GLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVL 1174
Query: 282 --------DKDKEGEALEVKENSGYLKAKQYMEEEN----YDKIISECSKEIDAEGKYMA 329
DK +A + + Y YMEE N Y I++ + I + K
Sbjct: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMD-KNSY 1233
Query: 330 EALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQD 389
A RA Y I A D ++ L +A ++ N + RG +Y++ Q + +D
Sbjct: 1234 IAFYNRALCYTKIRELQMALTDYG-IVLLLDATETVKLNTFLNRGLIYVELGQYGFALED 1292
Query: 390 FNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQA 449
F AA I N + H +++ EEAV F +++ P CF A
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP---------CFL---DA 1340
Query: 450 YTGNNSSQIQ--------AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDK 501
Y G +S ++ A K F + + P + + L Q +F KA +
Sbjct: 1341 YVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTI 1400
Query: 502 CIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNM 561
ID +P N Y + ++ LQ + ++ I+ A++I +F G I G+
Sbjct: 1401 AIDTDPKNYLAYEGRAVVCLQMGNNF-AAMQDINAAMKISTTAEF-LTNRGVIHEFMGHK 1458
Query: 562 EKAIDMFNKAINL 574
+ A+ + AI L
Sbjct: 1459 QNAMKDYQDAITL 1471
Score = 51.6 bits (122), Expect = 2e-06
Identities = 73/327 (22%), Positives = 130/327 (39%), Gaps = 53/327 (16%)
Query: 124 YFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELN 183
+ + ++E+A+ +T A+ + P +D N + + K+ +D KA+ +N
Sbjct: 1314 HHRINEFEEAVNFFTWALKINPCF--LDAYVGRGNSYMEYGHDEATKQAQKDFLKALHIN 1371
Query: 184 PKYVKAL------------FRRAKAHEKL----DNKKECLEDVTAVCILEGFQNQQSMLL 227
P Y+KA F++A H + D K + AV L+ N +M
Sbjct: 1372 PAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQD 1431
Query: 228 ADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKD-KE 286
+ +K+ E NR +I + M G K + KD ++
Sbjct: 1432 INAAMKI---STTAEFLTNR-------------------GVIHEFM--GHKQNAMKDYQD 1467
Query: 287 GEALEVKENSGYLKAKQ-YMEEENYDKIISECSKEI--DAEGKYMAEALLLRATFYLLIG 343
L K + Y A Y + + SK + D E +Y+ L+ RA ++
Sbjct: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYV---LMNRAITNTILK 1524
Query: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403
AK D VI + A R Y +Q L+ +D N A + P +A V
Sbjct: 1525 KYEEAKEDFANVIE----SCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580
Query: 404 YHHRGQLKILLDQVEEAVADFDECIRL 430
Y+ R +++ + +EEA+AD+++ + L
Sbjct: 1581 YNFRAKVRGKIGLIEEAMADYNQALDL 1607
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/225 (22%), Positives = 94/225 (41%), Gaps = 20/225 (8%)
Query: 295 NSGYLKAK-----QYMEEENYDKIISECSKEIDAEGK-YMAEALLLRATFYLLIGNANAA 348
N Y+KA+ + + K + + ID + K Y+A RA L +GN AA
Sbjct: 1371 NPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG--RAVVCLQMGNNFAA 1428
Query: 349 KPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRG 408
D++ + + A L RG ++ + +D+ A ++P+ + Y + G
Sbjct: 1429 MQDINAAMKISTT-----AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAG 1483
Query: 409 QLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEV 468
+ Q +A F + ++ PE+ + L +A T + + A + F V
Sbjct: 1484 NIYFHHRQFSQASDYFSKALKFDPENE-------YVLMNRAITNTILKKYEEAKEDFANV 1536
Query: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTY 513
I+ P A Y A +Q+ A+E +K + L+P++A Y
Sbjct: 1537 IESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Score = 40.8 bits (94), Expect = 0.004
Identities = 49/244 (20%), Positives = 92/244 (37%), Gaps = 27/244 (11%)
Query: 364 KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423
K A A +RG++Y + + + D ++P + Y HR + + D++ EA+ D
Sbjct: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
Query: 424 FDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYA 483
+ + + A K +YR I A+ + + IK P A+ Y
Sbjct: 974 LNYIHKYNKNNTEAYLSKA-EIYR------GKKDITLAILNYTQAIKSTPTDADIYFRRG 1026
Query: 484 QALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNK 543
+ + D+ + KCI +P + +GL + ++ +E + + ID++
Sbjct: 1027 EMYEITNKVLAIDD-FSKCIFYDPKRTDALLKRGLFYCE-NENWFAAIEDFTALLNIDHQ 1084
Query: 544 CDFA----------YETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHA 593
A Y+ Q M+K + S M+ A +YS C+
Sbjct: 1085 NSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSEL--------SPMQQALIYSFCENHDK 1136
Query: 594 QTEV 597
EV
Sbjct: 1137 AIEV 1140
Score = 40.4 bits (93), Expect = 0.005
Identities = 38/192 (19%), Positives = 75/192 (39%), Gaps = 15/192 (7%)
Query: 330 EALLLRATFYLLIGNANAAKP---DLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLS 386
+A + R Y+ G+ A K D K + + A +K R I G Q + +
Sbjct: 1339 DAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR----ISFGYNLQAQGKFQKA 1394
Query: 387 TQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALY 446
F +A D DP+N Y R + + + A+ D + +++ + L
Sbjct: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEF--------LT 1446
Query: 447 RQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506
+ Q AMK +++ I P+ + Y +QF +A + + K + +
Sbjct: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 507 PDNATTYVHKGL 518
P+N +++ +
Sbjct: 1507 PENEYVLMNRAI 1518
Score = 38.1 bits (87), Expect = 0.024
Identities = 83/403 (20%), Positives = 149/403 (36%), Gaps = 58/403 (14%)
Query: 106 LDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQ 165
LD + N+G Y + G+Y A++ + +A + T ++ +T A +
Sbjct: 1262 LDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHAT-----AMCHHR 1316
Query: 166 LQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSM 225
+ +++E T A+++NP ++ A R ++ + + ++ T Q Q+
Sbjct: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGH-----DEATK-------QAQKDF 1364
Query: 226 LLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDK 285
L A + K + Y L +F K++ + FT I + P
Sbjct: 1365 LKALHINPAYIKARISFGYN----LQAQGKFQKAW-NHFTIAIDTDPK-------NYLAY 1412
Query: 286 EGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYM--AEALLLRATFYLLIG 343
EG A+ + A Q +I+A K AE L R + +G
Sbjct: 1413 EGRAVVCLQMGNNFAAMQ----------------DINAAMKISTTAEFLTNRGVIHEFMG 1456
Query: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403
+ A D I+L NA G++Y +Q ++ F+ A DP+N V
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLAYFNA----GNIYFHHRQFSQASDYFSKALKFDPENEYV 1512
Query: 404 YHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMK 463
+R +L + EEA DF I P A + +A+ Q + A +
Sbjct: 1513 LMNRAITNTILKKYEEAKEDFANVIESCPFWAA-------VYFNRAHFYYCLKQYELAEE 1565
Query: 464 GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506
+ + P A Y A+ +A Y++ +DLE
Sbjct: 1566 DLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
Score = 37.0 bits (84), Expect = 0.053
Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 5/91 (5%)
Query: 129 KYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVK 188
KYE+A + + I CP V Y NRA + L++++ +D KA+ L P
Sbjct: 1525 KYEEAKEDFANVIESCPFWAAV-----YFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
Query: 189 ALFRRAKAHEKLDNKKECLEDVTAVCILEGF 219
RAK K+ +E + D LE +
Sbjct: 1580 VYNFRAKVRGKIGLIEEAMADYNQALDLEDY 1610
Score = 32.3 bits (72), Expect = 1.3
Identities = 23/100 (23%), Positives = 44/100 (44%), Gaps = 5/100 (5%)
Query: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTF----YQNRAAAFEQLQKWKEVA 173
K K N Y ++ ++ I+ Y + + E N D + + Y R A + +L K +
Sbjct: 879 KLKLNDYVESDLPQEVIKYYESEVKILTEEIN-DKTKYPAFAYCRRGAIYRKLGKLQSAM 937
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAV 213
D + + L P ++ A + R + D E L+D+ +
Sbjct: 938 NDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYI 977
>gi|225735595 RNA polymerase II associated protein 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 75.5 bits (184), Expect = 1e-13
Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 6/123 (4%)
Query: 113 RAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEV 172
+A + K++GN +FK GKYE+AI+CYT I+ + NRA A+ ++QK++E
Sbjct: 122 QAISEKDRGNGFFKEGKYERAIECYTRGIAADGAN-----ALLPANRAMAYLKIQKYEEA 176
Query: 173 AQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVL 232
+DCT+A+ L+ Y KA RR A L E +D V +LE N+Q++ K+
Sbjct: 177 EKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEP-GNKQAVTELSKIK 235
Query: 233 KLL 235
K L
Sbjct: 236 KEL 238
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/223 (26%), Positives = 90/223 (40%), Gaps = 29/223 (13%)
Query: 158 NRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE 217
NRA+A+ +L+K+ DC AV LN Y KA RR A L +E +D V LE
Sbjct: 13 NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 72
Query: 218 --GFQ-----NQQSMLLADK-----------VLKLLGKEKAKEKYKNREPLMPSPQFIKS 259
F+ + S LA K + G+ K E +N++ +
Sbjct: 73 PNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNG 132
Query: 260 YFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSK 319
+F + + +G + D L YLK ++Y E E +C++
Sbjct: 133 FFKEGKYERAIECYTRGIAA----DGANALLPANRAMAYLKIQKYEEAE------KDCTQ 182
Query: 320 EIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEAN 362
I +G Y ++A R T +G N AK D + V+ L+ N
Sbjct: 183 AILLDGSY-SKAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 224
Score = 40.0 bits (92), Expect = 0.006
Identities = 43/217 (19%), Positives = 85/217 (39%), Gaps = 25/217 (11%)
Query: 373 RGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRP 432
R S Y + ++ ++ D N+A ++ Y RG + L ++EEA D++ + L P
Sbjct: 14 RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 73
Query: 433 E-----SALAQAQKCFALYRQAY----------TGNNSSQIQAAMKGFEEVIKKFPRCAE 477
+ L + + A +Y T QI+A + + +K
Sbjct: 74 NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEK----DR 129
Query: 478 GYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKA 537
G + + ++ +A E Y + I + NA ++ + L+ Q + + ++A
Sbjct: 130 GNGFFKEG-----KYERAIECYTRGIAADGANALLPANRAMAYLK-IQKYEEAEKDCTQA 183
Query: 538 IEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574
I +D A+ GT G + +A F + L
Sbjct: 184 ILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLL 220
>gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 2
[Homo sapiens]
Length = 438
Score = 72.8 bits (177), Expect = 9e-13
Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 3/147 (2%)
Query: 99 PEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQN 158
P+ A + + +A K GNK FK G Y+ A + YTEA+ + P + + Y N
Sbjct: 185 PDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTN-AKLYCN 243
Query: 159 RAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEG 218
R +L+K + +DCT AV+L+ Y+KA RRA+ + + +E + D V E
Sbjct: 244 RGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEK 303
Query: 219 FQNQQSMLLADKVLKLLGKEKAKEKYK 245
+ LL + L+ L K K K+ YK
Sbjct: 304 -TKEHKQLLKNAQLE-LKKSKRKDYYK 328
Score = 39.3 bits (90), Expect = 0.011
Identities = 60/306 (19%), Positives = 114/306 (37%), Gaps = 31/306 (10%)
Query: 143 LCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDN 202
+CP KN +++Y NRAA L +++E D ++V L+ +V+ R K H L N
Sbjct: 1 MCP--KN---ASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGN 55
Query: 203 KKECLEDVTAVCILE--GFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSY 260
L+ Q QQ A+ V++ ++ A+ ++ R+ F
Sbjct: 56 AMAACRSFQRALELDHKNAQAQQEFKNANAVMEY--EKIAETDFEKRD--FRKVVFCMDR 111
Query: 261 FSSFTDDIISQPMLKGE------KSDEDKDKEGEALEVKENSG---YLKAKQYMEEENYD 311
F +LK E + E + + L + + Y++ E+ +
Sbjct: 112 ALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIE 171
Query: 312 KIISECSKEIDAEGKYMAEALLLRATFYLLI-----------GNANAAKPDLDKVISLKE 360
K + + + + + R L GN A + + +
Sbjct: 172 KAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDP 231
Query: 361 ANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEA 420
N+K A RG++ + ++ + +D A +D Y R Q + +Q EEA
Sbjct: 232 NNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEA 291
Query: 421 VADFDE 426
V D+++
Sbjct: 292 VRDYEK 297
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 72.8 bits (177), Expect = 9e-13
Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 3/147 (2%)
Query: 99 PEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQN 158
P+ A + + +A K GNK FK G Y+ A + YTEA+ + P + + Y N
Sbjct: 241 PDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTN-AKLYCN 299
Query: 159 RAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEG 218
R +L+K + +DCT AV+L+ Y+KA RRA+ + + +E + D V E
Sbjct: 300 RGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEK 359
Query: 219 FQNQQSMLLADKVLKLLGKEKAKEKYK 245
+ LL + L+ L K K K+ YK
Sbjct: 360 -TKEHKQLLKNAQLE-LRKSKRKDYYK 384
Score = 62.4 bits (150), Expect = 1e-09
Identities = 72/342 (21%), Positives = 132/342 (38%), Gaps = 31/342 (9%)
Query: 107 DMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQL 166
D + A+ K +GN Y+ Y +A YT+AI +CP KN +++Y NRAA L
Sbjct: 21 DQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCP--KN---ASYYGNRAATLMML 75
Query: 167 QKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE--GFQNQQS 224
+++E D ++V L+ +V+ R K H L N L+ Q QQ
Sbjct: 76 GRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQE 135
Query: 225 MLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGE------K 278
A+ V++ ++ A+ ++ R+ F F +LK E +
Sbjct: 136 FKNANAVMEY--EKIAETDFEKRD--FRKVVFCMDRALEFAPACHRFKILKAECLAMLGR 191
Query: 279 SDEDKDKEGEALEVKENSG---YLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLR 335
E + + L + + Y++ E+ +K + + + + + R
Sbjct: 192 YPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACR 251
Query: 336 ATFYLLI-----------GNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPL 384
L GN A + + + N+K A RG++ + ++
Sbjct: 252 NAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLD 311
Query: 385 LSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDE 426
+ +D A +D Y R Q + +Q EEAV D+++
Sbjct: 312 DAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEK 353
Score = 35.8 bits (81), Expect = 0.12
Identities = 52/246 (21%), Positives = 97/246 (39%), Gaps = 35/246 (14%)
Query: 347 AAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHH 406
A +P+L L + K A ++G+ Y ++ + + A D+ P+NA Y +
Sbjct: 13 ATEPEL-----LDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGN 67
Query: 407 RGQLKILLDQVEEAVADFDECIRL------------RPESALAQAQ-KCFALYRQAYTGN 453
R ++L + EA+ D + +RL + +L A C + R +
Sbjct: 68 RAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDH 127
Query: 454 NSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTY 513
++Q Q K V++ Y A+ +++ F K D+ ++ P
Sbjct: 128 KNAQAQQEFKNANAVME--------YEKIAETDFEKRDFRKVVFCMDRALEFAP-----A 174
Query: 514 VHK-GLLQLQWKQDLDRGLELISKAIEI---DNKCDFAYETMGTIEVQRGNMEKAIDMFN 569
H+ +L+ + L R E S A +I D+ A G +EKA+ F
Sbjct: 175 CHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFV 234
Query: 570 KAINLA 575
+A+ +A
Sbjct: 235 QALRMA 240
>gi|21361356 translocase of outer mitochondrial membrane 34 [Homo
sapiens]
Length = 309
Score = 72.4 bits (176), Expect = 1e-12
Identities = 38/107 (35%), Positives = 71/107 (66%), Gaps = 5/107 (4%)
Query: 111 LDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWK 170
+++A+ K +GN+ K G +++AI+ Y+E++ LC N++ +T Y NRA + L+++
Sbjct: 190 VEKARVLKEEGNELVKKGNHKKAIEKYSESL-LC---SNLESAT-YSNRALCYLVLKQYT 244
Query: 171 EVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE 217
E +DCT+A++L+ K VKA +RRA+AH+ L + K D++ + +E
Sbjct: 245 EAVKDCTEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIE 291
Score = 60.1 bits (144), Expect = 6e-09
Identities = 78/317 (24%), Positives = 133/317 (41%), Gaps = 35/317 (11%)
Query: 112 DRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDL---STFYQNRAAAFEQLQK 168
D + + GN+ F+ G+Y +A Y A+ + + + D S Y NRAA +
Sbjct: 7 DSVEELRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGN 66
Query: 169 WKEVAQDCTKAVELNPKYVKALFRRAKAHEKL--------DNKKECLEDVTAVCILEGFQ 220
++ +DCT A+ L P +K L RRA A+E L D K D +EG
Sbjct: 67 CRDCIKDCTSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGI- 125
Query: 221 NQQSMLLADKVLKLLGKEKAKEKYKNREPLMP----SPQFIKSYFSSFTDDIISQPMLKG 276
N+ + L D LG E ++ + P +P S Q K + S +++ K
Sbjct: 126 NRMTRALMDS----LGPE-----WRLKLPSIPLVPVSAQ--KRWNSLPSENHKEMAKSKS 174
Query: 277 EKSDEDKDKEGEALEVKENSGYLK--AKQYMEEENYDKIISECSKEIDAEGKYMAEALLL 334
+++ K++ A +V E + LK + +++ N+ K I + S+ + A
Sbjct: 175 KETTATKNRVPSAGDV-EKARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESA-TYSN 232
Query: 335 RATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAA 394
RA YL++ A D + + L NVK A +R + + S D +
Sbjct: 233 RALCYLVLKQYTEAVKDCTEALKLDGKNVK----AFYRRAQAHKALKDYKSSFADISNLL 288
Query: 395 DIDPQNADVYHHRGQLK 411
I+P+N R ++K
Sbjct: 289 QIEPRNGPAQKLRQEVK 305
>gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens]
Length = 499
Score = 69.3 bits (168), Expect = 1e-11
Identities = 42/133 (31%), Positives = 70/133 (52%), Gaps = 7/133 (5%)
Query: 110 SLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKW 169
+L RA+ K + N YFKA YE AI+ Y++AI L P+ + +Y NR+ A+ + + +
Sbjct: 24 ALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSN-----AIYYGNRSLAYLRTECY 78
Query: 170 KEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLL-- 227
D T+A+EL+ KY+K +RRA ++ L + L D V ++ M
Sbjct: 79 GYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQE 138
Query: 228 ADKVLKLLGKEKA 240
+K++K E+A
Sbjct: 139 CNKIVKQKAFERA 151
Score = 31.6 bits (70), Expect = 2.2
Identities = 40/242 (16%), Positives = 98/242 (40%), Gaps = 35/242 (14%)
Query: 366 RANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFD 425
RA L + + Y + + + + ++ A +++P NA Y +R + + A+ D
Sbjct: 27 RAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDAT 86
Query: 426 ECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQA 485
I L + YR+A + + +AA++ +E V+K P + Y +
Sbjct: 87 RAIEL-------DKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQEC 139
Query: 486 --LTDQQQFGKA-----------DEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLE 532
+ Q+ F +A D + + + +E + + + G + + + ++L ++
Sbjct: 140 NKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKEL---MQ 196
Query: 533 LISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAH 592
++ KC AY+ + ++ ++ +K L ++ ++ ++C H
Sbjct: 197 WYKDQKKLHRKC--AYQILVQVK----------EVLSKLSTLVETTLKETEKITVCGDTH 244
Query: 593 AQ 594
Q
Sbjct: 245 GQ 246
>gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens]
Length = 929
Score = 66.6 bits (161), Expect = 6e-11
Identities = 38/110 (34%), Positives = 63/110 (57%), Gaps = 3/110 (2%)
Query: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCT 177
K +GN++F+ Y+ A Y++A+ L T+ L+T Y+NRAA + + + + A D +
Sbjct: 10 KEEGNRHFQLQDYKAATNSYSQALKL--TKDKALLATLYRNRAACGLKTESYVQAASDAS 67
Query: 178 KAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-GFQNQQSML 226
+A+++N +KAL+RR +A E L + +DV LE QN Q ML
Sbjct: 68 RAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEML 117
>gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens]
Length = 931
Score = 66.6 bits (161), Expect = 6e-11
Identities = 38/110 (34%), Positives = 63/110 (57%), Gaps = 3/110 (2%)
Query: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCT 177
K +GN++F+ Y+ A Y++A+ L T+ L+T Y+NRAA + + + + A D +
Sbjct: 10 KEEGNRHFQLQDYKAATNSYSQALKL--TKDKALLATLYRNRAACGLKTESYVQAASDAS 67
Query: 178 KAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-GFQNQQSML 226
+A+++N +KAL+RR +A E L + +DV LE QN Q ML
Sbjct: 68 RAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEML 117
>gi|56181387 STIP1 homology and U-box containing protein 1 [Homo
sapiens]
Length = 303
Score = 64.3 bits (155), Expect = 3e-10
Identities = 55/234 (23%), Positives = 104/234 (44%), Gaps = 27/234 (11%)
Query: 83 RKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAIS 142
++ EG A G G PE + AQ K +GN+ F KY +A CY AI+
Sbjct: 4 KEEKEGGARLGAGGGSPEKSPS---------AQELKEQGNRLFVGRKYPEAAACYGRAIT 54
Query: 143 LCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDN 202
+N ++ +Y NRA + ++Q+ ++ DC +A+EL+ + VKA F + ++++
Sbjct: 55 -----RNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMES 109
Query: 203 KKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFS 262
E + ++ L +Q + D + L K K E + + SY S
Sbjct: 110 YDEAIANLQRAYSL---AKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLS 166
Query: 263 SFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISE 316
+ + E + ++ EG+ E+ +++A+Q E +DK +++
Sbjct: 167 R-----LIAAERERELEECQRNHEGD-----EDDSHVRAQQACIEAKHDKYMAD 210
Score = 33.9 bits (76), Expect = 0.45
Identities = 21/89 (23%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 490 QQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYE 549
+++ +A Y + I P A Y ++ L L+ +Q ++ L +A+E+D + A+
Sbjct: 40 RKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQH-EQALADCRRALELDGQSVKAHF 98
Query: 550 TMGTIEVQRGNMEKAIDMFNKAINLAKSE 578
+G +++ + ++AI +A +LAK +
Sbjct: 99 FLGQCQLEMESYDEAIANLQRAYSLAKEQ 127
>gi|29725607 smooth muscle cell associated protein-1 isoform 2 [Homo
sapiens]
Length = 944
Score = 64.3 bits (155), Expect = 3e-10
Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 31/215 (14%)
Query: 85 TPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLC 144
T G +P P P PGA + + +GN+ FK G Y A+ YT+A+ L
Sbjct: 2 TVSGPGTPEP---RPATPGA-------SSVEQLRKEGNELFKCGDYGGALAAYTQALGLD 51
Query: 145 PTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKK 204
T + D + ++NRAA +L+ + + + +KA+E + VKAL+RR++A EKL
Sbjct: 52 ATPQ--DQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGGDVKALYRRSQALEKLGRLD 109
Query: 205 ECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSF 264
+ + D+ LE ++ + + + + G+ + K +Y + F
Sbjct: 110 QAVLDLQRCVSLE----PKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMF-------- 157
Query: 265 TDDIISQPMLKGEKSDEDKDKEGEALEV--KENSG 297
I+ P EK E K K + L V +E++G
Sbjct: 158 --QILLDP---EEKGTEKKQKASQNLVVLAREDAG 187
>gi|24308141 small glutamine-rich tetratricopeptide repeat
(TPR)-containing, beta [Homo sapiens]
Length = 304
Score = 63.2 bits (152), Expect = 7e-10
Identities = 44/163 (26%), Positives = 75/163 (46%), Gaps = 7/163 (4%)
Query: 113 RAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEV 172
+A K++GN + K Y A+ CYT+AI L P + +Y NRAAA +L + +
Sbjct: 84 KADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNN-----AVYYCNRAAAQSKLGHYTDA 138
Query: 173 AQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCIL--EGFQNQQSMLLADK 230
+DC KA+ ++ KY KA R A L+ +E + L E + ++ +A++
Sbjct: 139 IKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQ 198
Query: 231 VLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPM 273
L+ + + L+ +P FI S + + Q M
Sbjct: 199 KLREVSSPTGTGLSFDMASLINNPAFISMAASLMQNPQVQQLM 241
Score = 44.7 bits (104), Expect = 3e-04
Identities = 38/161 (23%), Positives = 73/161 (45%), Gaps = 9/161 (5%)
Query: 415 DQVEEAVADFDECIRLRPESA-LAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFP 473
+ +E A+ + ++ PE LA +Q ++ ++ N+ + ++ E+V K
Sbjct: 30 ESLEVAIQCLETVFKISPEDTHLAVSQPLTEMFTSSFCKNDVLPLSNSVP--EDVGKADQ 87
Query: 474 RCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLEL 533
EG ++ + A + Y + I+L+P+NA Y ++ Q + D ++
Sbjct: 88 LKDEG-----NNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTD-AIKD 141
Query: 534 ISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574
KAI ID+K AY MG E+A+ + KA++L
Sbjct: 142 CEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDL 182
Score = 35.0 bits (79), Expect = 0.20
Identities = 29/113 (25%), Positives = 49/113 (43%), Gaps = 7/113 (6%)
Query: 397 DPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSS 456
D AD G + + AV + + I L P +A+ + A Q+ G+ +
Sbjct: 81 DVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAA---QSKLGHYTD 137
Query: 457 QIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDN 509
A+K E+ I + ++ Y ALT +F +A Y K +DL+P+N
Sbjct: 138 ----AIKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPEN 186
>gi|19923193 heat shock 70kD protein binding protein [Homo sapiens]
Length = 369
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/136 (29%), Positives = 66/136 (48%), Gaps = 8/136 (5%)
Query: 94 PGSGHPEGPG---AHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNV 150
P + P+ G A + +D+A K + G+ ++AI +T+AI L P
Sbjct: 91 PDTDAPQEMGDENAEITEEMMDQANDKKVAAIEALNDGELQKAIDLFTDAIKLNPR---- 146
Query: 151 DLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDV 210
L+ Y RA+ F +LQK +DC +A+E+NP + R KAH L + +E D+
Sbjct: 147 -LAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDL 205
Query: 211 TAVCILEGFQNQQSML 226
C L+ ++ +ML
Sbjct: 206 ALACKLDYDEDASAML 221
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/216 (25%), Positives = 99/216 (45%), Gaps = 26/216 (12%)
Query: 255 QFIKSYFSSFTDDIISQPMLKGEKSDED-KDKEGEALEVKENSGYLKAKQYMEEENYDKI 313
+F++ + S + P + KS+E+ K+++ ++ +V+E+ LKA + EE+ +I
Sbjct: 29 RFLREWVESMGGKV--PPATQKAKSEENTKEEKPDSKKVEED---LKADEPSSEESDLEI 83
Query: 314 ISE--------CSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKL 365
E +E+ E + E ++ +A + +L K I L +KL
Sbjct: 84 DKEGVIEPDTDAPQEMGDENAEITEEMMDQANDKKVAAIEALNDGELQKAIDLFTDAIKL 143
Query: 366 RANALI---KRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAV- 421
I KR S++++ Q+P + +D + A +I+P +A Y RG+ LL EEA
Sbjct: 144 NPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAH 203
Query: 422 -------ADFDECIRLRPESALAQAQKCFALYRQAY 450
D+DE + +AQK A +R+ Y
Sbjct: 204 DLALACKLDYDEDASAMLKEVQPRAQK-IAEHRRKY 238
Score = 35.8 bits (81), Expect = 0.12
Identities = 21/64 (32%), Positives = 31/64 (48%)
Query: 454 NSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTY 513
N ++Q A+ F + IK PR A YA A Q+ A D+ I++ PD+A Y
Sbjct: 126 NDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPY 185
Query: 514 VHKG 517
+G
Sbjct: 186 KWRG 189
>gi|4826932 peptidylprolyl isomerase D [Homo sapiens]
Length = 370
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/177 (27%), Positives = 82/177 (46%), Gaps = 23/177 (12%)
Query: 87 EGRASPAPGSG--HPEGP-GAHLDMNSLDR----AQAAKNKGNKYFKAGKYEQAIQCYTE 139
+G P GSG HP+ P A +D+ +D+ + KN GN +FK+ +E AI+ Y E
Sbjct: 189 DGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAE 248
Query: 140 AISLCPTEKNVDLS-----------TFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVK 188
+ + K V + + N A ++ W+ C +A+EL+P K
Sbjct: 249 VLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTK 308
Query: 189 ALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLAD--KVLKLLGKEKAKEK 243
AL+RRA+ + L + L D+ +G + + A+ KV + + +K KEK
Sbjct: 309 ALYRRAQGWQGLKEYDQALADLKKA---QGIAPEDKAIQAELLKVKQKIKAQKDKEK 362
>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
Length = 705
Score = 61.6 bits (148), Expect = 2e-09
Identities = 36/103 (34%), Positives = 54/103 (52%), Gaps = 8/103 (7%)
Query: 114 AQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVA 173
A A K KGN+ F G YE AI Y+E + EK D+ Y NRA A+ +L+ +++
Sbjct: 106 ADALKEKGNEAFAEGNYETAILRYSEGL-----EKLKDMKVLYTNRAQAYMKLEDYEKAL 160
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDN---KKECLEDVTAV 213
DC A++ + K KA F KA+ L N +EC + + +
Sbjct: 161 VDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEI 203
>gi|89179321 smooth muscle cell associated protein-1 isoform 3 [Homo
sapiens]
Length = 929
Score = 60.8 bits (146), Expect = 3e-09
Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 21/182 (11%)
Query: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCT 177
+ +GN+ FK G Y A+ YT+A+ L T + D + ++NRAA +L+ + + + +
Sbjct: 10 RKEGNELFKCGDYGGALAAYTQALGLDATPQ--DQAVLHRNRAACHLKLEDYDKAETEAS 67
Query: 178 KAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGK 237
KA+E + VKAL+RR++A EKL + + D+ LE ++ + + + + G+
Sbjct: 68 KAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLE----PKNKVFQEALRNIGGQ 123
Query: 238 EKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEV--KEN 295
+ K +Y + F I+ P EK E K K + L V +E+
Sbjct: 124 IQEKVRYMSSTDAKVEQMF----------QILLDP---EEKGTEKKQKASQNLVVLARED 170
Query: 296 SG 297
+G
Sbjct: 171 AG 172
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/307 (22%), Positives = 128/307 (41%), Gaps = 27/307 (8%)
Query: 298 YLKAKQYMEEENYDKIISECSKEIDAEGK------YMAEALLLRATF---YLLIGNANAA 348
YLKA + + N+ S +A+G+ + +A+ L F Y+ +GN
Sbjct: 170 YLKAIE--TQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKE 227
Query: 349 KPDLDKVISLKEANVKLRANALIKRGSM---YMQQQQPLLSTQDFNMAADIDPQNADVYH 405
D+ ++ + L N + G++ Y +Q L+ + A ++ P D Y
Sbjct: 228 ARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYC 287
Query: 406 HRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGF 465
+ V EA ++ +RL P A +L A I+ A++ +
Sbjct: 288 NLANALKEKGSVAEAEDCYNTALRLCPTHA-------DSLNNLANIKREQGNIEEAVRLY 340
Query: 466 EEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQ 525
+ ++ FP A ++ A L Q + +A Y + I + P A Y + G L+ Q
Sbjct: 341 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNT-LKEMQ 399
Query: 526 DLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLY 585
D+ L+ ++AI+I+ A+ + +I GN+ +AI + A+ L K + A+
Sbjct: 400 DVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKL-KPDFPDAY-- 456
Query: 586 SLCDAAH 592
C+ AH
Sbjct: 457 --CNLAH 461
Score = 42.7 bits (99), Expect = 0.001
Identities = 45/232 (19%), Positives = 91/232 (39%), Gaps = 28/232 (12%)
Query: 370 LIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIR 429
L+ S++ Q ++ S +A +P A+ Y + G + Q++EA+ + +R
Sbjct: 48 LLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALR 107
Query: 430 LRPESALAQAQKCFALYR--------QAYTG--NNSSQIQAAMKGFEEVIKKFPRCAEGY 479
L+P+ AL QAY + + ++K R E
Sbjct: 108 LKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAK 167
Query: 480 ALYAQALTDQQQFG-----------------KADEMYDKCIDLEPDNATTYVHKGLLQLQ 522
A Y +A+ Q F A ++K + L+P+ Y++ G + L+
Sbjct: 168 ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV-LK 226
Query: 523 WKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574
+ DR + +A+ + + + + ++G ++ AID + +AI L
Sbjct: 227 EARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIEL 278
Score = 40.8 bits (94), Expect = 0.004
Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Query: 114 AQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVA 173
A A N + + GK ++A+ Y EAI + PT + Y N +++Q +
Sbjct: 351 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPT-----FADAYSNMGNTLKEMQDVQGAL 405
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECL 207
Q T+A+++NP + A A H+ N E +
Sbjct: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAI 439
Score = 34.3 bits (77), Expect = 0.34
Identities = 23/89 (25%), Positives = 42/89 (47%), Gaps = 4/89 (4%)
Query: 489 QQQFGKADEMYDKCIDL---EPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCD 545
+ Q G + C+ L EPDN + + Q ++ LDR + AI+ +
Sbjct: 21 EYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRR-LDRSAHFSTLAIKQNPLLA 79
Query: 546 FAYETMGTIEVQRGNMEKAIDMFNKAINL 574
AY +G + +RG +++AI+ + A+ L
Sbjct: 80 EAYSNLGNVYKERGQLQEAIEHYRHALRL 108
Score = 30.4 bits (67), Expect = 4.9
Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 12/96 (12%)
Query: 119 NKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTK 178
N N + G +A CY A+ LCPT + N A + +E + K
Sbjct: 288 NLANALKEKGSVAEAEDCYNTALRLCPTH-----ADSLNNLANIKREQGNIEEAVRLYRK 342
Query: 179 AVELNPKYVKA-------LFRRAKAHEKLDNKKECL 207
A+E+ P++ A L ++ K E L + KE +
Sbjct: 343 ALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAI 378
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/307 (22%), Positives = 128/307 (41%), Gaps = 27/307 (8%)
Query: 298 YLKAKQYMEEENYDKIISECSKEIDAEGK------YMAEALLLRATF---YLLIGNANAA 348
YLKA + + N+ S +A+G+ + +A+ L F Y+ +GN
Sbjct: 180 YLKAIE--TQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKE 237
Query: 349 KPDLDKVISLKEANVKLRANALIKRGSM---YMQQQQPLLSTQDFNMAADIDPQNADVYH 405
D+ ++ + L N + G++ Y +Q L+ + A ++ P D Y
Sbjct: 238 ARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYC 297
Query: 406 HRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGF 465
+ V EA ++ +RL P A +L A I+ A++ +
Sbjct: 298 NLANALKEKGSVAEAEDCYNTALRLCPTHA-------DSLNNLANIKREQGNIEEAVRLY 350
Query: 466 EEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQ 525
+ ++ FP A ++ A L Q + +A Y + I + P A Y + G L+ Q
Sbjct: 351 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNT-LKEMQ 409
Query: 526 DLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLY 585
D+ L+ ++AI+I+ A+ + +I GN+ +AI + A+ L K + A+
Sbjct: 410 DVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKL-KPDFPDAY-- 466
Query: 586 SLCDAAH 592
C+ AH
Sbjct: 467 --CNLAH 471
Score = 42.7 bits (99), Expect = 0.001
Identities = 45/232 (19%), Positives = 91/232 (39%), Gaps = 28/232 (12%)
Query: 370 LIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIR 429
L+ S++ Q ++ S +A +P A+ Y + G + Q++EA+ + +R
Sbjct: 58 LLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALR 117
Query: 430 LRPESALAQAQKCFALYR--------QAYTG--NNSSQIQAAMKGFEEVIKKFPRCAEGY 479
L+P+ AL QAY + + ++K R E
Sbjct: 118 LKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAK 177
Query: 480 ALYAQALTDQQQFG-----------------KADEMYDKCIDLEPDNATTYVHKGLLQLQ 522
A Y +A+ Q F A ++K + L+P+ Y++ G + L+
Sbjct: 178 ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV-LK 236
Query: 523 WKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574
+ DR + +A+ + + + + ++G ++ AID + +AI L
Sbjct: 237 EARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIEL 288
Score = 40.8 bits (94), Expect = 0.004
Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Query: 114 AQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVA 173
A A N + + GK ++A+ Y EAI + PT + Y N +++Q +
Sbjct: 361 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPT-----FADAYSNMGNTLKEMQDVQGAL 415
Query: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECL 207
Q T+A+++NP + A A H+ N E +
Sbjct: 416 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAI 449
Score = 34.3 bits (77), Expect = 0.34
Identities = 23/89 (25%), Positives = 42/89 (47%), Gaps = 4/89 (4%)
Query: 489 QQQFGKADEMYDKCIDL---EPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCD 545
+ Q G + C+ L EPDN + + Q ++ LDR + AI+ +
Sbjct: 31 EYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRR-LDRSAHFSTLAIKQNPLLA 89
Query: 546 FAYETMGTIEVQRGNMEKAIDMFNKAINL 574
AY +G + +RG +++AI+ + A+ L
Sbjct: 90 EAYSNLGNVYKERGQLQEAIEHYRHALRL 118
Score = 30.4 bits (67), Expect = 4.9
Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 12/96 (12%)
Query: 119 NKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTK 178
N N + G +A CY A+ LCPT + N A + +E + K
Sbjct: 298 NLANALKEKGSVAEAEDCYNTALRLCPTH-----ADSLNNLANIKREQGNIEEAVRLYRK 352
Query: 179 AVELNPKYVKA-------LFRRAKAHEKLDNKKECL 207
A+E+ P++ A L ++ K E L + KE +
Sbjct: 353 ALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAI 388
>gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens]
Length = 676
Score = 57.0 bits (136), Expect = 5e-08
Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 18/172 (10%)
Query: 115 QAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWK---- 170
+ K + N+ F ++ QAIQ Y++A+ P + Y NRAAA+ + +KW
Sbjct: 362 ERVKQQANEAFACQQWTQAIQLYSKAVQRAPHN-----AMLYGNRAAAYMK-RKWDGDHY 415
Query: 171 EVAQDCTKAVELNPKYVKALFRRAKAHEKLD---NKKECLEDVTAVCILEGFQNQQSMLL 227
+ +DC KA+ LNP ++KA FR A+ +L ECL+D + + L
Sbjct: 416 DALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALECLDDFKGKFPEQAHSSACDALG 475
Query: 228 ADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKS 279
D L K +EK + P +P ++S +S D I M+ E+S
Sbjct: 476 RDITAALFSKNDGEEK---KGPGGGAPVRLRS--TSRKDSISEDEMVLRERS 522
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 57.0 bits (136), Expect = 5e-08
Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 14/209 (6%)
Query: 326 KYMAEALLLRATFYLLIGNA-NAAKPDLDKVISLKEANVKLRAN---ALIKRGSMYMQQQ 381
KY A Y+ + N A + L++ L + +R + A I RG + ++
Sbjct: 518 KYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMN 577
Query: 382 QPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQK 441
+PL + + + A ++D NAD++++ + I L + EA+ +F+ + L P+ L
Sbjct: 578 KPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKL----- 632
Query: 442 CFALYRQAYTGNNSSQIQ---AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEM 498
AL+ A S +++ A K I + P A GY D ++ +A+
Sbjct: 633 --ALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIW 690
Query: 499 YDKCIDLEPDNATTYVHKGLLQLQWKQDL 527
K I L+ D + + LL Q ++L
Sbjct: 691 MKKAIKLQADFRSALFNLALLYSQTAKEL 719
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/88 (27%), Positives = 47/88 (53%), Gaps = 3/88 (3%)
Query: 488 DQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEID-NKCDF 546
++ + +AD++Y + I + PD Y+ +G L L+ + L + E KA+E+D N D
Sbjct: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPL-KAKEAYLKALELDRNNADL 599
Query: 547 AYETMGTIEVQRGNMEKAIDMFNKAINL 574
Y + + ++ +A+ FN+A+ L
Sbjct: 600 WYN-LAIVHIELKEPNEALKNFNRALEL 626
Score = 37.4 bits (85), Expect = 0.040
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 112 DRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKE 171
D QA ++G K K +A + Y +A+ L N DL + N A +L++ E
Sbjct: 561 DFKQAYISRGELLLKMNKPLKAKEAYLKALEL--DRNNADL---WYNLAIVHIELKEPNE 615
Query: 172 VAQDCTKAVELNPKYVKALFRRA 194
++ +A+ELNPK+ ALF A
Sbjct: 616 ALKNFNRALELNPKHKLALFNSA 638
Score = 33.5 bits (75), Expect = 0.58
Identities = 57/279 (20%), Positives = 107/279 (38%), Gaps = 47/279 (16%)
Query: 129 KYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVK 188
+ E+A Q Y +AIS+ P D Y +R ++ K + + KA+EL+
Sbjct: 544 RLEEADQLYRQAISMRP-----DFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
Query: 189 ALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNRE 248
+ A H +L E L++ L +++ ++ + V++ G+ K + + + R
Sbjct: 599 LWYNLAIVHIELKEPNEALKNFNRALELNP-KHKLALFNSAIVMQESGEVKLRPEARKR- 656
Query: 249 PLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEE 308
+ SY + D L D+ KD E E ++K
Sbjct: 657 --------LLSYINEEPLDANGYFNLGMLAMDDKKDNEAEI--------WMK-------- 692
Query: 309 NYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRAN 368
K I + + + AL A Y A P L++++ ++K
Sbjct: 693 ----------KAIKLQADFRS-ALFNLALLYSQTAKELKALPILEELLRYYPDHIK---- 737
Query: 369 ALIKRGSMYMQQQQPLLSTQD-FNMAADIDPQNADVYHH 406
LI +G + M Q++ +L + F ++DP N H+
Sbjct: 738 GLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHN 776
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 56.2 bits (134), Expect = 8e-08
Identities = 120/564 (21%), Positives = 220/564 (39%), Gaps = 98/564 (17%)
Query: 79 RNSERKTPEGRASPAP---------GSGHPEGPGAHLDMNSLDRAQAAKN--KGNKYFKA 127
R+ R+ PE + AP G P+GP L +A+ + + N+
Sbjct: 19 RSRRRREPESPPASAPIPLFGADTIGQRSPDGP-------VLSKAEFVEKVRQSNQACHD 71
Query: 128 GKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYV 187
G + AI Y EA+++ P Y NR+AA+ ++Q++ + D KA LNPK+
Sbjct: 72 GDFHTAIVLYNEALAVDPQN-----CILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWP 126
Query: 188 KALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNR 247
KA FR+ A + L + L + Q+ +S+ L L+G +A K R
Sbjct: 127 KAYFRQGVALQYLGRHADALAAFASGLA----QDPKSLQL------LVGMVEAAMKSPMR 176
Query: 248 EPLMPSPQFI------KSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLK- 300
+ L P+ Q + KS F ++ Q +L AL++ S L+
Sbjct: 177 DSLEPTYQQLQKMKLDKSPF--VVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRG 234
Query: 301 ------AKQYMEEENYDKIISECSKEIDA-------EGKYMAEALLLRATFYLLIGNANA 347
+ Y N +K +++D G+ A L A F GN
Sbjct: 235 SVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSK--GNYRE 292
Query: 348 AKPD--LDKVISLKEANVKLRANALIKRGSMY-----------MQQQQPLLSTQDFNMAA 394
A + V+++K + + ++AL G +Y +Q LL+ Q + +
Sbjct: 293 ALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELS 352
Query: 395 DIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRL------RPESALAQAQKCFALYRQ 448
+ A + G + I + E AV ++ +++ + E A A + A + +
Sbjct: 353 E-----ARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYR 407
Query: 449 AYTGNNSSQIQAAMKGFEEVIKKF--PRCAEGYALYAQALTD--------QQQFGKADEM 498
S ++ +E+++K R G A+ + D +QQ G A+++
Sbjct: 408 RNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDL 467
Query: 499 YDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQR 558
D+ + + +H Q K D D L+L + I + Y G
Sbjct: 468 KDRAAEGRASSNLGIIH------QMKGDYDTALKLHKTHLCIAQELS-DYAAQGRAYGNM 520
Query: 559 GNMEKAIDMFNKAINLAKSEMEMA 582
GN A+ M+++A+ + E++++
Sbjct: 521 GNAYNALGMYDQAVKYHRQELQIS 544
Score = 39.7 bits (91), Expect = 0.008
Identities = 64/293 (21%), Positives = 115/293 (39%), Gaps = 51/293 (17%)
Query: 317 CSKEIDAEGKYMAEAL---------LLRATFYLLIGNANAAKPDLDKVIS---------- 357
C K+I+ K+ + L L A+ Y +G A DK +
Sbjct: 726 CKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQ 785
Query: 358 -LKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADI-----DPQ-NADVYHHRGQL 410
L + + RA+ + ++YM + ++ + + D+ DP A VY + G
Sbjct: 786 ELSDLPGECRAHGHL--AAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGIT 843
Query: 411 KILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIK 470
K+ ++ +EEA+ F++ + + L Q ++ + N A+ +EE IK
Sbjct: 844 KMNMNVMEEAIGYFEQQLAM-----LQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIK 898
Query: 471 KFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQD-LDR 529
+ E Y AQ+L Q KA H+ + LQ ++
Sbjct: 899 YY----EQYLSVAQSLNRMQDQAKAYRGLGNG------------HRAMGSLQQALVCFEK 942
Query: 530 GLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMA 582
L + + E NK AY +G++ Q GN E+AI + +N+A+ + A
Sbjct: 943 RLVVAHELGEAFNKAQ-AYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRA 994
Score = 29.6 bits (65), Expect = 8.4
Identities = 14/33 (42%), Positives = 21/33 (63%)
Query: 111 LDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISL 143
LDR +A N G+ Y G YE+AI+ Y + +S+
Sbjct: 874 LDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906
>gi|156627581 tetratricopeptide repeat domain 4 [Homo sapiens]
Length = 387
Score = 56.2 bits (134), Expect = 8e-08
Identities = 43/181 (23%), Positives = 87/181 (48%), Gaps = 11/181 (6%)
Query: 112 DRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKE 171
++A+ K++GN YFK Y++A+ YTE + + +++ + Y NRAAA L ++
Sbjct: 77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLN-AVLYTNRAAAQYYLGNFRS 135
Query: 172 VAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQ--QSMLLAD 229
D T A +L P ++KA+ R A H +L + E + ++ + + + AD
Sbjct: 136 ALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKAD 195
Query: 230 KVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEA 289
K+ ++ ++ K K ++ + +++ I ++ + E + ED+D E
Sbjct: 196 KLKRIEQRDVRKANLKEKKERNQNEALLQA--------IKARNIRLSEAACEDEDSASEG 247
Query: 290 L 290
L
Sbjct: 248 L 248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,124,111
Number of Sequences: 37866
Number of extensions: 1108049
Number of successful extensions: 7108
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 192
Number of HSP's that attempted gapping in prelim test: 6137
Number of HSP's gapped (non-prelim): 882
length of query: 608
length of database: 18,247,518
effective HSP length: 108
effective length of query: 500
effective length of database: 14,157,990
effective search space: 7078995000
effective search space used: 7078995000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.