Guide to the Human Genome
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Search of human proteins with 5454156

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5454156 ubiquitin specific protease 16 isoform a [Homo
sapiens]
         (823 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]   1673   0.0  
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]  1673   0.0  
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]  1667   0.0  
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]           552   e-157
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]   134   3e-31
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                  100   9e-21
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]             96   1e-19
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]    91   6e-18
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]    90   7e-18
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]     90   7e-18
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]     90   7e-18
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...    89   2e-17
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]    88   4e-17
gi|41152235 ubiquitin specific protease 51 [Homo sapiens]              87   5e-17
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]                   87   8e-17
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                 87   8e-17
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]              86   1e-16
gi|22550104 ubiquitin specific protease 32 [Homo sapiens]              86   1e-16
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]             86   2e-16
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]             86   2e-16
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]             86   2e-16
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]             85   2e-16
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]         84   7e-16
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]                 82   2e-15
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]                 82   2e-15
gi|183396780 ubiquitin specific protease 20 [Homo sapiens]             80   8e-15
gi|183397136 ubiquitin specific protease 20 [Homo sapiens]             80   8e-15
gi|183397134 ubiquitin specific protease 20 [Homo sapiens]             80   8e-15
gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo ...    80   8e-15
gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo ...    80   8e-15

>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 1673 bits (4332), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK 60
           MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK
Sbjct: 1   MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK 60

Query: 61  AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD 120
           AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD
Sbjct: 61  AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD 120

Query: 121 NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM 180
           NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM
Sbjct: 121 NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM 180

Query: 181 AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD 240
           AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD
Sbjct: 181 AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD 240

Query: 241 LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS 300
           LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS
Sbjct: 241 LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS 300

Query: 301 QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG 360
           QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG
Sbjct: 301 QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG 360

Query: 361 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD 420
           GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD
Sbjct: 361 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD 420

Query: 421 NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE 480
           NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE
Sbjct: 421 NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE 480

Query: 481 YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI 540
           YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI
Sbjct: 481 YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI 540

Query: 541 NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT 600
           NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT
Sbjct: 541 NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT 600

Query: 601 PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR 660
           PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR
Sbjct: 601 PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR 660

Query: 661 QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL 720
           QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL
Sbjct: 661 QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL 720

Query: 721 DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD 780
           DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD
Sbjct: 721 DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD 780

Query: 781 IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL 823
           IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL
Sbjct: 781 IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL 823


>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 1673 bits (4332), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK 60
           MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK
Sbjct: 1   MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK 60

Query: 61  AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD 120
           AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD
Sbjct: 61  AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD 120

Query: 121 NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM 180
           NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM
Sbjct: 121 NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM 180

Query: 181 AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD 240
           AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD
Sbjct: 181 AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD 240

Query: 241 LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS 300
           LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS
Sbjct: 241 LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS 300

Query: 301 QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG 360
           QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG
Sbjct: 301 QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG 360

Query: 361 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD 420
           GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD
Sbjct: 361 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD 420

Query: 421 NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE 480
           NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE
Sbjct: 421 NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE 480

Query: 481 YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI 540
           YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI
Sbjct: 481 YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI 540

Query: 541 NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT 600
           NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT
Sbjct: 541 NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT 600

Query: 601 PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR 660
           PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR
Sbjct: 601 PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR 660

Query: 661 QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL 720
           QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL
Sbjct: 661 QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL 720

Query: 721 DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD 780
           DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD
Sbjct: 721 DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD 780

Query: 781 IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL 823
           IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL
Sbjct: 781 IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL 823


>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
          Length = 822

 Score = 1667 bits (4316), Expect = 0.0
 Identities = 822/823 (99%), Positives = 822/823 (99%), Gaps = 1/823 (0%)

Query: 1   MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK 60
           MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK
Sbjct: 1   MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK 60

Query: 61  AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD 120
           AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD
Sbjct: 61  AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD 120

Query: 121 NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM 180
           NEVQYCSSNQLGQVVDYVRKQASITTPKP EKDNGNIELENKKLEKESKNEQEREKKENM
Sbjct: 121 NEVQYCSSNQLGQVVDYVRKQASITTPKP-EKDNGNIELENKKLEKESKNEQEREKKENM 179

Query: 181 AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD 240
           AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD
Sbjct: 180 AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD 239

Query: 241 LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS 300
           LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS
Sbjct: 240 LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS 299

Query: 301 QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG 360
           QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG
Sbjct: 300 QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG 359

Query: 361 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD 420
           GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD
Sbjct: 360 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD 419

Query: 421 NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE 480
           NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE
Sbjct: 420 NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE 479

Query: 481 YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI 540
           YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI
Sbjct: 480 YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI 539

Query: 541 NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT 600
           NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT
Sbjct: 540 NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT 599

Query: 601 PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR 660
           PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR
Sbjct: 600 PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR 659

Query: 661 QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL 720
           QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL
Sbjct: 660 QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL 719

Query: 721 DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD 780
           DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD
Sbjct: 720 DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD 779

Query: 781 IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL 823
           IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL
Sbjct: 780 IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL 822


>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
          Length = 814

 Score =  552 bits (1423), Expect = e-157
 Identities = 318/835 (38%), Positives = 479/835 (57%), Gaps = 50/835 (5%)

Query: 4   KRTKGKTVPID-DSSETLEP--VCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK 60
           KR+K  TVP D DSS+ +     C+H+   +   ++K+A+    W++C +C  + +  D 
Sbjct: 15  KRSKRPTVPHDEDSSDDIAVGLTCQHVSHAISVNHVKRAIAENLWSVCSECLKERRFYDG 74

Query: 61  AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD 120
               T +   +WLCLKCG QGCG+NS+ QH+LKH+ + R+EPHC++++L  W +WCY CD
Sbjct: 75  QLVLTSD---IWLCLKCGFQGCGKNSESQHSLKHFKSSRTEPHCIIINLSTWIIWCYECD 131

Query: 121 NEVQ-YCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKEN 179
            ++  +C+   L Q+VD+++K AS T              +     +  K  +E+ + + 
Sbjct: 132 EKLSTHCNKKVLAQIVDFLQKHASKT--------------QTSAFSRIMKLCEEKCETDE 177

Query: 180 MAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPP 239
           + K     N    ++V+G++NLGNTCFFNAVMQNL+QT  L +L+ E+K S T +KI P 
Sbjct: 178 IQKGGKCRN----LSVRGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPS 233

Query: 240 DLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQD 299
             +  +PL + L  PGPLT A+  FL+ M+ET+KG ++PK LF+Q+C+KA RFK +QQQD
Sbjct: 234 SDSQLDPLVVELSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQQQD 293

Query: 300 SQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEK-LDEELKNKVKDYEKKKSMPSFVDRI 358
           SQELL YLLD +R EE +R+   ILKAF N T K  D+E + KVK Y K+    +F+DRI
Sbjct: 294 SQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRI 353

Query: 359 FGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSV-NDKNLKKTVEDEDQDSEE 417
           F GELTS +MC++C  +S V + F+D+SLP+++++  K  +    N  +++ + D D   
Sbjct: 354 FIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSKPLLWGRMNKYRSLRETDHD--- 410

Query: 418 EKDNDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPE 477
            + + +   E    P    KH   K K Q     K  R+    +      N+   + + +
Sbjct: 411 -RYSGNVTIENIHQPRAAKKHSSSKDKSQLIHDRKCIRKLSSGETVTYQKNENLEM-NGD 468

Query: 478 DSEYEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDM 537
              + + M+ +  +N      S++   H E   +  D + +    ES +           
Sbjct: 469 SLMFASLMNSESRLNESPTDDSEKEASHSE---SNVDADSEPSESESASKQTGLFRSSSG 525

Query: 538 KNINMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDE----INIE 593
             +  D  L  L++         Y  E  +G+ +++     L L++ +  D+     N  
Sbjct: 526 SGVQPDGPLYPLSAGKL-----LYTKETDSGDKEMAEAISELRLSSTVTGDQDFDRENQP 580

Query: 594 ILNDSHTPGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLL 653
           +   ++    +   + +  P+ AF TL+   +  + ECSIQ CLYQFT  E L   NKLL
Sbjct: 581 LNISNNLCFLEGKHLRSYSPQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLL 640

Query: 654 CEVCTRRQCNGPKANIKGERK--HVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVN 711
           CE CT+ +    +     E+K   VYTNA+KQ+LIS  P VL LHLKRF QAG +LRKVN
Sbjct: 641 CENCTKNKQKYQEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKRFHQAGLSLRKVN 700

Query: 712 KHIKFPEILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSH 771
           +H+ FP +LDLAPFC+  CKN A    +VLY LYG+VEHSG+MR GHYTAY K RT +  
Sbjct: 701 RHVDFPLMLDLAPFCSATCKN-ASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRK 759

Query: 772 LS-NLVLHGDIP--QDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL 823
           LS +     ++P  +  + ES GQW H+SDT++Q VP ++ L++QAYLLFYER+L
Sbjct: 760 LSEHNTKKKNVPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYERVL 814


>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
          Length = 828

 Score =  134 bits (337), Expect = 3e-31
 Identities = 178/829 (21%), Positives = 313/829 (37%), Gaps = 160/829 (19%)

Query: 8   GKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEE 67
           GK   I +        C H+    E    K+ L+      CQDCK               
Sbjct: 23  GKQEKIPNKMSAFRNHCPHLDSVGEI--TKEDLIQKSLGTCQDCKVQG------------ 68

Query: 68  KPSVWLCL--KCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQY 125
            P++W CL  +C + GCG  SQ  H+  H    +   H L ++L    VWCY C  EV  
Sbjct: 69  -PNLWACLENRCSYVGCGE-SQVDHSTIH---SQETKHYLTVNLTTLRVWCYACSKEVFL 123

Query: 126 CSSNQLGQVVDYVRKQASITTPKPAE-KDNGNIELENKKLEKESKNEQEREKKENMAKEN 184
                    + +VR+   I      + K   N  L+   +      + E ++++ +    
Sbjct: 124 DRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARG 183

Query: 185 PPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALT 244
                     + GL N+GNTC+ NA +Q LS  P L +             ++   LA T
Sbjct: 184 ----------LTGLKNIGNTCYMNAALQALSNCPPLTQFF-----------LDCGGLART 222

Query: 245 EPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELL 304
           +      + P      +        +++ G V P  LF  +      F+GY QQD+QE L
Sbjct: 223 D------KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFL 276

Query: 305 RYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELT 364
           R L+D                        L EELK +V + E+     +  + +   +  
Sbjct: 277 RCLMD-----------------------LLHEELKEQVMEVEEDPQTITTEETMEEDKSQ 313

Query: 365 SMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSY 424
           S +    C + S    +         ++++G +  ++ N + T+  +D ++  E   D  
Sbjct: 314 SDVDFQSCESCSNSDRA---------ENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQ 364

Query: 425 IKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSEYEAE 484
            ++  +  +  +   +    + +  +  +   Q+ ++ ++          H   SEY  +
Sbjct: 365 KEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQI----------HSRASEYITD 414

Query: 485 MSLQGEVNIKSNHISQEGVMHKEYCVNQKDLN---GQA---KMIESVTDNQKSTEEVDMK 538
           +    +++      S EGV  +      K  N   G A   K  +S +  +K   +    
Sbjct: 415 VH-SNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRS 473

Query: 539 NINMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKN--LNLNAALHPDEI-NIEIL 595
            I+   D  +++S      +   +T  +  ++ +    K     L+++ HP  I      
Sbjct: 474 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533

Query: 596 NDSHTPGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCE 655
            +++ P   +          AF     +  F     ++Q CL  F   ++L+  N   CE
Sbjct: 534 GEAYAPQGWI----------AFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCE 583

Query: 656 VCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIK 715
            C + +                 N  K   +   P +L +HLKRF+       K++ H+ 
Sbjct: 584 KCKKLR-----------------NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 626

Query: 716 FP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVVEHSGTMRSGHYTAYAKARTANSHL 772
           FP E LDL PF       +A+++    V Y L  V+ H GT  SGHY AY +     ++L
Sbjct: 627 FPLEGLDLQPF-------LAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR-----NNL 674

Query: 773 SNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
           +NL                 W+   D  V  V  + V N++AY+LFY +
Sbjct: 675 NNL-----------------WYEFDDQSVTEVSESTVQNAEAYVLFYRK 706


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 99/352 (28%), Positives = 144/352 (40%), Gaps = 48/352 (13%)

Query: 70  SVWLCLKCGHQGCGRNSQEQHALKHY------LTPRSEP-------HCLVLSLDNWSVWC 116
           S W+CL C    CGR     HA KHY      LT   +        H + +   ++S +C
Sbjct: 37  SPWVCLTCSSVHCGRYVNG-HAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYC 95

Query: 117 YVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREK 176
           Y CD+ V   +  +LG +V  VR+            +N     +  K  K  +N     K
Sbjct: 96  YRCDDFV--VNDTKLG-LVQKVREHLQ-------NLENSAFTADRHKKRKLLENSTLNSK 145

Query: 177 KENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKI 236
              + K N    S   I   GL NLGNTCF NA++Q+LS         KE+      V++
Sbjct: 146 ---LLKVN---GSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPA----VEL 195

Query: 237 EPPDLALTEPLEINLEPPGPLTLA--MSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKG 294
                A         +    ++L     + L  + +  +   +P+ LF  V K    F+G
Sbjct: 196 RNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRG 255

Query: 295 YQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKK---KSM 351
           YQQQD+ E +RYLLD +  E         L+   N   +     +N       K      
Sbjct: 256 YQQQDAHEFMRYLLDHLHLE---------LQGGFNGVSRSAILQENSTLSASNKCCINGA 306

Query: 352 PSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKN 403
            + V  IFGG L + + C  C T S   + FLDLSL +      K+S N +N
Sbjct: 307 STVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQEN 358



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 52/213 (24%)

Query: 612 DPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKG 671
           D  + F +  ++   N   CS++ CL  FT  E+L +    +C  C ++Q          
Sbjct: 343 DIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQ---------- 392

Query: 672 ERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKC 730
                   + K+  I   P VL LHLKRF    +   KV+ +++FP   LD      +KC
Sbjct: 393 -------KSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLD------MKC 439

Query: 731 KNVAEENT---RVLYSLYGVVEHSGT-MRSGHYTAYAKARTANSHLSNLVLHGDIPQDFE 786
             +  EN+     LY L  VV H G+ + SGHYTAYA                       
Sbjct: 440 YLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYA----------------------- 476

Query: 787 MESKGQWFHISDTHVQAVPTTKVLNSQAYLLFY 819
              +G+WFH +D+ V       V+ ++AY+LFY
Sbjct: 477 -THEGRWFHFNDSTVTLTDEETVVKAKAYILFY 508


>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
          Length = 952

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 64/193 (33%), Positives = 99/193 (51%), Gaps = 14/193 (7%)

Query: 197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 256
           GLSNLGNTCF N+ +Q LS TP L E     K           +L    PL +     G 
Sbjct: 261 GLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQ--------EELNFDNPLGMR----GE 308

Query: 257 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 316
           +  + ++ + +M   K   VTP+   +QV + A +F GYQQQD QELL +LLDG+  E+ 
Sbjct: 309 IAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLH-EDL 367

Query: 317 QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVS 376
            R+ K       ++  + D+ +  +  +   K++    VD IF G   S ++C +C  +S
Sbjct: 368 NRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVD-IFHGLFKSTLVCPECAKIS 426

Query: 377 LVHESFLDLSLPV 389
           +  + F  L+LP+
Sbjct: 427 VTFDPFCYLTLPL 439



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 49/190 (25%), Positives = 78/190 (41%), Gaps = 46/190 (24%)

Query: 633 IQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPV 692
           ++ C+  FT  EKL   +   C  C   Q                  A K++ +   PPV
Sbjct: 759 LKDCIELFTTKEKLGAEDPWYCPNCKEHQ-----------------QATKKLDLWSLPPV 801

Query: 693 LTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHS 751
           L +HLKRF  + +   K++  + FP   LD++ F       +        Y+L  V  H 
Sbjct: 802 LVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL------INPNAGPCRYNLIAVSNHY 855

Query: 752 GTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLN 811
           G M  GHYTA+AK +                        G+W++  D+ V      ++++
Sbjct: 856 GGMGGGHYTAFAKNK----------------------DDGKWYYFDDSSVSTASEDQIVS 893

Query: 812 SQAYLLFYER 821
             AY+LFY+R
Sbjct: 894 KAAYVLFYQR 903


>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
          Length = 942

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 104/431 (24%), Positives = 167/431 (38%), Gaps = 66/431 (15%)

Query: 8   GKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEE 67
           GK   I +        C H+    E    K+ L+      CQDCK               
Sbjct: 23  GKQEKIPNKMSAFRNHCPHLDSVGEI--TKEDLIQKSLGTCQDCKVQG------------ 68

Query: 68  KPSVWLCL--KCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQY 125
            P++W CL  +C + GCG  SQ  H+  H    +   H L ++L    VWCY C  EV  
Sbjct: 69  -PNLWACLENRCSYVGCGE-SQVDHSTIH---SQETKHYLTVNLTTLRVWCYACSKEVFL 123

Query: 126 CSSNQLGQVVDYVRKQASITTPKPAE-KDNGNIELENKKLEKESKNEQEREKKENMAKEN 184
                    + +VR+   I      + K   N  L+   +      + E ++++ +    
Sbjct: 124 DRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARG 183

Query: 185 PPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALT 244
                     + GL N+GNTC+ NA +Q LS  P L +             ++   LA T
Sbjct: 184 ----------LTGLKNIGNTCYMNAALQALSNCPPLTQFF-----------LDCGGLART 222

Query: 245 EPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELL 304
           +      + P      +        +++ G V P  LF  +      F+GY QQD+QE L
Sbjct: 223 D------KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFL 276

Query: 305 RYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVK-DYEKKKSMPSFVDRIFGGEL 363
           R L+D +  E  ++V +        +TE+  EE K++   D++  +S  S  DR      
Sbjct: 277 RCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESC-SNSDRAENENG 335

Query: 364 TSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKK---TVEDEDQDSEEEKD 420
           +     D   T  L+            DD++  +   D   +K    +   + + E +KD
Sbjct: 336 SRCFSEDNNETTMLIQ-----------DDENNSEMSKDWQKEKMCNKINKVNSEGEFDKD 384

Query: 421 NDSYIKERSDI 431
            DS I E  D+
Sbjct: 385 RDS-ISETVDL 394



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 49/193 (25%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           ++Q CL  F   ++L+  N   CE C + +                 N  K   +   P 
Sbjct: 568 TLQDCLAAFFARDELKGDNMYSCEKCKKLR-----------------NGVKFCKVQNFPE 610

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVV 748
           +L +HLKRF+       K++ H+ FP E LDL PF       +A+++    V Y L  V+
Sbjct: 611 ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPF-------LAKDSPAQIVTYDLLSVI 663

Query: 749 EHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTK 808
            H GT  SGHY AY +     ++L+NL                 W+   D  V  V  + 
Sbjct: 664 CHHGTASSGHYIAYCR-----NNLNNL-----------------WYEFDDQSVTEVSEST 701

Query: 809 VLNSQAYLLFYER 821
           V N++AY+LFY +
Sbjct: 702 VQNAEAYVLFYRK 714



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 18/47 (38%), Positives = 26/47 (55%)

Query: 343 KDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
           K  ++ K   S +  IF G + S + C  C  VS+  E+F DLSLP+
Sbjct: 463 KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPI 509


>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
          Length = 911

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 98/402 (24%), Positives = 159/402 (39%), Gaps = 64/402 (15%)

Query: 37  KKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCL--KCGHQGCGRNSQEQHALKH 94
           K+ L+      CQDCK                P++W CL  +C + GCG  SQ  H+  H
Sbjct: 19  KEDLIQKSLGTCQDCKVQG-------------PNLWACLENRCSYVGCGE-SQVDHSTIH 64

Query: 95  YLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAE-KD 153
               +   H L ++L    VWCY C  EV           + +VR+   I      + K 
Sbjct: 65  ---SQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI 121

Query: 154 NGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQN 213
             N  L+   +      + E ++++ +              + GL N+GNTC+ NA +Q 
Sbjct: 122 PSNTTLKTPLVAVFDDLDIEADEEDELRARG----------LTGLKNIGNTCYMNAALQA 171

Query: 214 LSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKK 273
           LS  P L +             ++   LA T+      + P      +        +++ 
Sbjct: 172 LSNCPPLTQFF-----------LDCGGLARTD------KKPAICKSYLKLMTELWHKSRP 214

Query: 274 GVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEK 333
           G V P  LF  +      F+GY QQD+QE LR L+D +  E  ++V +        +TE+
Sbjct: 215 GSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEE 274

Query: 334 LDEELKNKVK-DYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDD 392
             EE K++   D++  +S  S  DR      +     D   T  L+            DD
Sbjct: 275 TMEEDKSQSDVDFQSCESC-SNSDRAENENGSRCFSEDNNETTMLIQ-----------DD 322

Query: 393 QSGKKSVNDKNLKK---TVEDEDQDSEEEKDNDSYIKERSDI 431
           ++  +   D   +K    +   + + E +KD DS I E  D+
Sbjct: 323 ENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDS-ISETVDL 363



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 49/193 (25%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           ++Q CL  F   ++L+  N   CE C + +                 N  K   +   P 
Sbjct: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLR-----------------NGVKFCKVQNFPE 579

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVV 748
           +L +HLKRF+       K++ H+ FP E LDL PF       +A+++    V Y L  V+
Sbjct: 580 ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPF-------LAKDSPAQIVTYDLLSVI 632

Query: 749 EHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTK 808
            H GT  SGHY AY +     ++L+NL                 W+   D  V  V  + 
Sbjct: 633 CHHGTASSGHYIAYCR-----NNLNNL-----------------WYEFDDQSVTEVSEST 670

Query: 809 VLNSQAYLLFYER 821
           V N++AY+LFY +
Sbjct: 671 VQNAEAYVLFYRK 683



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 18/47 (38%), Positives = 26/47 (55%)

Query: 343 KDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
           K  ++ K   S +  IF G + S + C  C  VS+  E+F DLSLP+
Sbjct: 432 KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPI 478


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)

Query: 186 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 245
           P +S  Q  + GL NLGNTCF N+ +Q LS T  L +   + +    I +  P       
Sbjct: 292 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 344

Query: 246 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 305
                L   G +  A ++ + +M   +   V P+   +QV + A +F GYQQQDSQELL 
Sbjct: 345 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 399

Query: 306 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 365
           +LLDG+  E+  RV K       ++  + D  +  +  +  + ++    VD  F G   S
Sbjct: 400 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 457

Query: 366 MIMCDQCRTVSLVHESFLDLSLPV 389
            ++C +C  VS+  + F  L+LP+
Sbjct: 458 TLVCPECAKVSVTFDPFCYLTLPL 481



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           +++ C+  FT  E L + +   C  C + Q                  A K+  +   P 
Sbjct: 777 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 819

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 749
           +L +HLKRF    +   K++  ++FP   L+++ F C L  +         +Y L  V  
Sbjct: 820 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 872

Query: 750 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809
           H G M  GHYTAYAK +                        G+W++  D++V      ++
Sbjct: 873 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 910

Query: 810 LNSQAYLLFYER 821
           +   AY+LFY+R
Sbjct: 911 VTKAAYVLFYQR 922


>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 63/204 (30%), Positives = 100/204 (49%), Gaps = 14/204 (6%)

Query: 186 PMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTE 245
           P +S  Q  + GL NLGNTCF N+ +Q LS T  L +   + +    I +  P       
Sbjct: 245 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP------- 297

Query: 246 PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLR 305
                L   G +  A ++ + +M   +   V P+   +QV + A +F GYQQQDSQELL 
Sbjct: 298 -----LGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLA 352

Query: 306 YLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTS 365
           +LLDG+  E+  RV K       ++  + D  +  +  +  + ++    VD  F G   S
Sbjct: 353 FLLDGLH-EDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD-TFHGLFKS 410

Query: 366 MIMCDQCRTVSLVHESFLDLSLPV 389
            ++C +C  VS+  + F  L+LP+
Sbjct: 411 TLVCPECAKVSVTFDPFCYLTLPL 434



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 48/192 (25%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           +++ C+  FT  E L + +   C  C + Q                  A K+  +   P 
Sbjct: 730 ALRDCIELFTTMETLGEHDPWYCPNCKKHQ-----------------QATKKFDLWSLPK 772

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPF-CTLKCKNVAEENTRVLYSLYGVVE 749
           +L +HLKRF    +   K++  ++FP   L+++ F C L  +         +Y L  V  
Sbjct: 773 ILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPY-------VYDLIAVSN 825

Query: 750 HSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809
           H G M  GHYTAYAK +                        G+W++  D++V      ++
Sbjct: 826 HYGAMGVGHYTAYAKNKL----------------------NGKWYYFDDSNVSLASEDQI 863

Query: 810 LNSQAYLLFYER 821
           +   AY+LFY+R
Sbjct: 864 VTKAAYVLFYQR 875


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
           sapiens]
          Length = 605

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 66/205 (32%), Positives = 100/205 (48%), Gaps = 19/205 (9%)

Query: 187 MNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEP 246
           MNS     + GL NLGNTCF N+++Q LS T  LR+   +      +        AL E 
Sbjct: 258 MNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEE 317

Query: 247 LEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRY 306
               ++     T+  S        +   VV+P E  +Q+ + A RF GY QQD+QE LR+
Sbjct: 318 FAKLIQ-----TIWTS--------SPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRF 364

Query: 307 LLDGMRAEEHQRVSKGILKAFGN--STEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELT 364
           LLDG+    H  V++  L+   N  + + L ++ K +    +  +   S +  +F G+L 
Sbjct: 365 LLDGL----HNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLK 420

Query: 365 SMIMCDQCRTVSLVHESFLDLSLPV 389
           S + C  C   S V + F DLSLP+
Sbjct: 421 SSLTCTDCGYCSTVFDPFWDLSLPI 445



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 60/193 (31%), Positives = 83/193 (43%), Gaps = 49/193 (25%)

Query: 630 ECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLA 689
           E ++  C+  FT+ + L    K  C  C   +C G K  IK            +  I   
Sbjct: 452 EVTLMDCMRLFTKEDVLDGDEKPTC--C---RCRGRKRCIK------------KFSIQRF 494

Query: 690 PPVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTR-VLYSLYGV 747
           P +L LHLKRF ++     K+   + FP   LDL  F        A ENT   +Y+LY V
Sbjct: 495 PKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREF--------ASENTNHAVYNLYAV 546

Query: 748 VEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTT 807
             HSGT   GHYTAY ++                         G+W   +D+ V  + ++
Sbjct: 547 SNHSGTTMGGHYTAYCRS----------------------PGTGEWHTFNDSSVTPMSSS 584

Query: 808 KVLNSQAYLLFYE 820
           +V  S AYLLFYE
Sbjct: 585 QVRTSDAYLLFYE 597


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 66/208 (31%), Positives = 100/208 (48%), Gaps = 19/208 (9%)

Query: 184 NPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLAL 243
           N   NS     + GL NLGNTCF N+++Q LS T  LR+   +      +        AL
Sbjct: 46  NKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTAL 105

Query: 244 TEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQEL 303
            E     ++     T+  S        +   VV+P E  +Q+ + A RF GY QQD+QE 
Sbjct: 106 VEEFAKLIQ-----TIWTS--------SPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEF 152

Query: 304 LRYLLDGMRAEEHQRVSKGILKAFGN--STEKLDEELKNKVKDYEKKKSMPSFVDRIFGG 361
           LR+LLDG+    H  V++  L+   N  + + L ++ K +    +  +   S +  +F G
Sbjct: 153 LRFLLDGL----HNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVG 208

Query: 362 ELTSMIMCDQCRTVSLVHESFLDLSLPV 389
           +L S + C  C   S V + F DLSLP+
Sbjct: 209 QLKSSLTCTDCGYCSTVFDPFWDLSLPI 236



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 60/193 (31%), Positives = 83/193 (43%), Gaps = 49/193 (25%)

Query: 630 ECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLA 689
           E ++  C+  FT+ + L    K  C  C   +C G K  IK            +  I   
Sbjct: 243 EVTLMDCMRLFTKEDVLDGDEKPTC--C---RCRGRKRCIK------------KFSIQRF 285

Query: 690 PPVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTR-VLYSLYGV 747
           P +L LHLKRF ++     K+   + FP   LDL  F        A ENT   +Y+LY V
Sbjct: 286 PKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREF--------ASENTNHAVYNLYAV 337

Query: 748 VEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTT 807
             HSGT   GHYTAY ++                         G+W   +D+ V  + ++
Sbjct: 338 SNHSGTTMGGHYTAYCRS----------------------PGTGEWHTFNDSSVTPMSSS 375

Query: 808 KVLNSQAYLLFYE 820
           +V  S AYLLFYE
Sbjct: 376 QVRTSDAYLLFYE 388


>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
          Length = 711

 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 62/220 (28%), Positives = 91/220 (41%), Gaps = 49/220 (22%)

Query: 610 NEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANI 669
           +++PE A  T++ R+       S+  CL  FTR E L  + K+ C  C            
Sbjct: 527 SQNPERADSTVS-RDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQS---------- 575

Query: 670 KGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLK 729
                  Y  + KQ+ +   P V   HLKRF+  G   RK+N  I FP  LD+ PF    
Sbjct: 576 -------YQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLELDMTPFLAST 628

Query: 730 CKNVAEEN--------TRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDI 781
            ++  +E             YSL+ V+ H GT+ SGHYT++ +                 
Sbjct: 629 KESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIR----------------- 671

Query: 782 PQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
                 + K QWF   D  +       +L S+ YLLFY +
Sbjct: 672 ------QQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHK 705



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 82/340 (24%), Positives = 134/340 (39%), Gaps = 48/340 (14%)

Query: 74  CLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSSNQLG- 132
           CL C   GC     E+H  KH  T +   H L + L +  ++C++C + V      Q+  
Sbjct: 249 CLSCVFFGC---FTEKHIHKHAETKQ---HHLAVDLYHGVIYCFMCKDYVYDKDIEQIAK 302

Query: 133 QVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQ 192
           +  + + +  + T+   + +       E+K+   E+K   E+E K    K+     S   
Sbjct: 303 ETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETK---EQEPKLVKPKKKRRKKSVYT 359

Query: 193 ITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLE 252
           + ++GL NLGNTCF N ++Q L+  P+L++     K                    I   
Sbjct: 360 VGLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKC-----------------IMTS 402

Query: 253 PPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMR 312
           P   L   MS   + M    +    P +L   +   A    GY+QQD+ E L  +LD + 
Sbjct: 403 PSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVL- 461

Query: 313 AEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQC 372
              H +   G             +E  N              +D+IF G L S + C  C
Sbjct: 462 -HRHSKDDSG------------GQEANN-------PNCCNCIIDQIFTGGLQSDVTCQAC 501

Query: 373 RTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDED 412
            +VS   +   D+SL +    +   S N +    TV  +D
Sbjct: 502 HSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDD 541


>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
          Length = 1318

 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 65/227 (28%), Positives = 102/227 (44%), Gaps = 25/227 (11%)

Query: 167 ESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKE 226
           +S  E+E E+K+            C     GL NLGNTCF N+V+Q+LS T  LR+   +
Sbjct: 479 DSVEEEEEEEKK-----------VCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHD 527

Query: 227 VKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVC 286
                 I    P            L   G L +  +  L  + +       P +L + V 
Sbjct: 528 RSFEAEINYNNP------------LGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVA 575

Query: 287 KKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYE 346
            KA +F GY Q D+QE + +LLDG+  E+  R+         +S  + DE +  +     
Sbjct: 576 SKASQFTGYAQHDAQEFMAFLLDGLH-EDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRH 634

Query: 347 KKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQ 393
           K ++  SF+  +F G+  S ++C  C  VS+  + FL L +P+   Q
Sbjct: 635 KMRN-DSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 64/214 (29%), Positives = 86/214 (40%), Gaps = 47/214 (21%)

Query: 611  EDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIK 670
            EDP +A       E       ++  CL  FTR E L       C  C + +         
Sbjct: 1044 EDPGSA------GEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHR--------- 1088

Query: 671  GERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLR-KVNKHIKFP-EILDLAPFCTL 728
                     A KQ+L+   P VL + LKRF    F  R K+N  ++FP   LDL+ FC  
Sbjct: 1089 --------EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG 1140

Query: 729  KCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQD-FEM 787
            +     +E     Y LY V+ H G M  GHYTA A+                +P D    
Sbjct: 1141 Q-----KEEQLPSYDLYAVINHYGGMIGGHYTACAR----------------LPNDRSSQ 1179

Query: 788  ESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
             S   W    D+ V  V  ++V+   AY+LFY R
Sbjct: 1180 RSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRR 1213


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 58/211 (27%), Positives = 86/211 (40%), Gaps = 49/211 (23%)

Query: 620 LANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTN 679
           + N E   +   ++  CL +FTR E L  + K+ C  C                 H Y  
Sbjct: 349 VVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGC-----------------HSYQE 391

Query: 680 AKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKN------- 732
           + KQ+ +   P V   HLKRF+ +    RK+  ++ FP  LD+ PF     ++       
Sbjct: 392 STKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQYQ 451

Query: 733 --VAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESK 790
                 N    YSL+ VV H GT+ SGHYT++ +                       + K
Sbjct: 452 QPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIR-----------------------QHK 488

Query: 791 GQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
            QWF   D  +       VL+S+ YLLFY +
Sbjct: 489 DQWFKCDDAIITKASIKDVLDSEGYLLFYHK 519



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 81/322 (25%), Positives = 125/322 (38%), Gaps = 76/322 (23%)

Query: 74  CLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSSNQLGQ 133
           CL C   GC     ++H  +H    +++ H L + L    ++C++C              
Sbjct: 76  CLYCVFFGC---FTKKHIHEH---AKAKRHNLAIDLMYGGIYCFLCQ------------- 116

Query: 134 VVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKENPP---MNSP 190
             DY+  +      K  ++    ++   +K       ++E E    + K NP    + S 
Sbjct: 117 --DYIYDKDMEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELE----LLKHNPKRRKITSN 170

Query: 191 CQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEIN 250
           C I ++GL NLGNTCF N ++Q L+ TP+LR                  D  L++     
Sbjct: 171 CTIGLRGLINLGNTCFMNCIVQALTHTPLLR------------------DFFLSDRHRCE 212

Query: 251 LEPPGP-LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLD 309
           ++ P   L   MS    E     +    P +L   V   A    GY+QQD+ E L   LD
Sbjct: 213 MQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALD 272

Query: 310 GMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPS----FVDRIFGGELTS 365
            +      R  KG                     D  KK + P+     +D+IF G L S
Sbjct: 273 VL-----HRHCKG--------------------DDNGKKANNPNHCNCIIDQIFTGGLQS 307

Query: 366 MIMCDQCRTVSLVHESFLDLSL 387
            + C  C  VS   + F D+SL
Sbjct: 308 DVTCQVCHGVSTTIDPFWDISL 329


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 14/200 (7%)

Query: 190 PCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEI 249
           P +    GLSNLGNTCF N+ +Q +S T  L +      +SG  +     +L  T P+ +
Sbjct: 526 PTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYF----ISGRHLY----ELNRTNPIGM 577

Query: 250 NLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLD 309
                G +       + E+    +  V P +L   + K A +F G+QQQDSQELL +LLD
Sbjct: 578 K----GHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLD 633

Query: 310 GMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMC 369
           G+  E+  RV +       +S  + D E+  +  D   +++    VD +F G+L S + C
Sbjct: 634 GLH-EDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVD-LFHGQLRSQVKC 691

Query: 370 DQCRTVSLVHESFLDLSLPV 389
             C  +S+  + F  LSLP+
Sbjct: 692 KTCGHISVRFDPFNFLSLPL 711



 Score = 37.7 bits (86), Expect = 0.044
 Identities = 22/88 (25%), Positives = 38/88 (43%), Gaps = 25/88 (28%)

Query: 736  ENTRV--LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQW 793
            E+T +  +Y+LY +  HSG +  GHY  YAK                           +W
Sbjct: 1304 EDTHIKPIYNLYAISCHSGILSGGHYITYAK-----------------------NPNCKW 1340

Query: 794  FHISDTHVQAVPTTKVLNSQAYLLFYER 821
            +  +D+  + +   ++    AY+LFYE+
Sbjct: 1341 YCYNDSSCEELHPDEIDTDSAYILFYEQ 1368



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 17/85 (20%)

Query: 632  SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
            ++  CL  FT  E+L ++    C  C                   +  A K++ +   PP
Sbjct: 1032 NLDSCLRAFTSEEELGESEMYYCSKCK-----------------THCLATKKLDLWRLPP 1074

Query: 692  VLTLHLKRFQQAGFNLRKVNKHIKF 716
             L +HLKRFQ       K  K ++F
Sbjct: 1075 FLIIHLKRFQFVNDQWIKSQKIVRF 1099


>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
          Length = 1604

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 65/200 (32%), Positives = 100/200 (50%), Gaps = 14/200 (7%)

Query: 190 PCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEI 249
           P +    GLSNLGNTCF N+ +Q +S T  L +      +SG  +     +L  T P+ +
Sbjct: 728 PTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYF----ISGRHLY----ELNRTNPIGM 779

Query: 250 NLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLD 309
                G +       + E+    +  V P +L   + K A RF G+QQQDSQELL +LLD
Sbjct: 780 K----GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLD 835

Query: 310 GMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMC 369
           G+  E+  RV +       +S  + D E+  +  D   +++    VD +F G+L S + C
Sbjct: 836 GLH-EDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVD-LFHGQLRSQVKC 893

Query: 370 DQCRTVSLVHESFLDLSLPV 389
             C  +S+  + F  LSLP+
Sbjct: 894 KTCGHISVRFDPFNFLSLPL 913



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 25/88 (28%)

Query: 736  ENTRV--LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQW 793
            E+TR+  +Y+LY +  HSG +  GHY  YAK                           +W
Sbjct: 1502 EDTRIKPIYNLYAISCHSGILGGGHYVTYAK-----------------------NPNCKW 1538

Query: 794  FHISDTHVQAVPTTKVLNSQAYLLFYER 821
            +  +D+  + +   ++    AY+LFYE+
Sbjct: 1539 YCYNDSSCKELHPDEIDTDSAYILFYEQ 1566



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 32/115 (27%), Positives = 42/115 (36%), Gaps = 22/115 (19%)

Query: 603  TKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQC 662
            T    VV+E         A  E  N D C     L  FT  E+L +     C  C     
Sbjct: 1210 TSQERVVDEHESVEQSRRAQAEPINLDSC-----LRAFTSEEELGENEMYYCSKCK---- 1260

Query: 663  NGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP 717
                          +  A K++ +   PP+L +HLKRFQ       K  K +KFP
Sbjct: 1261 -------------THCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFP 1302


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 46/194 (23%)

Query: 627  NTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLI 686
            +T +C++Q CL  F++ EKL D N+  C  C  R+                 ++ K++ I
Sbjct: 958  STSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR-----------------DSLKKIEI 1000

Query: 687  SLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLY 745
               PPVL +HLKRF   G   +K+   + FP E LDL+ +       +  +N    Y+L+
Sbjct: 1001 WKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYV------IGPKNNLKKYNLF 1054

Query: 746  GVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVP 805
             V  H G +  GHYTAY K                        ++ +WF   D  V  + 
Sbjct: 1055 SVSNHYGGLDGGHYTAYCK----------------------NAARQRWFKFDDHEVSDIS 1092

Query: 806  TTKVLNSQAYLLFY 819
             + V +S AY+LFY
Sbjct: 1093 VSSVKSSAAYILFY 1106



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 53/194 (27%), Positives = 88/194 (45%), Gaps = 16/194 (8%)

Query: 197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 256
           GL NLGNTC+ N+++Q L   P L +          I +               L   G 
Sbjct: 778 GLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNL------------LGHKGE 825

Query: 257 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 316
           +       +  +   +   ++PK+    + K   +F GY QQDSQELL +L+DG+  + +
Sbjct: 826 VAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLN 885

Query: 317 QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSM-PSFVDRIFGGELTSMIMCDQCRTV 375
           +  ++   K   N  + LD + K     ++K K +  S +  +F G+  S + C  C   
Sbjct: 886 KADNRKRYKEENN--DHLD-DFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKK 942

Query: 376 SLVHESFLDLSLPV 389
           S   E+F+ LSLP+
Sbjct: 943 SRTFEAFMYLSLPL 956



 Score = 33.9 bits (76), Expect = 0.63
 Identities = 15/87 (17%), Positives = 43/87 (49%)

Query: 396 KKSVNDKNLKKTVEDEDQDSEEEKDNDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQR 455
           +K+  +K L++  ++E ++   +++ +   K++ +         Q+KAK++ +K+   Q 
Sbjct: 474 EKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQA 533

Query: 456 RQQKIQGKVLHLNDICTIDHPEDSEYE 482
           +++  +       +I  +     SE+E
Sbjct: 534 KKEDKETSAKRGKEITGVKRQSKSEHE 560


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 46/194 (23%)

Query: 627  NTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLI 686
            +T +C++Q CL  F++ EKL D N+  C  C  R+                 ++ K++ I
Sbjct: 958  STSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR-----------------DSLKKIEI 1000

Query: 687  SLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLY 745
               PPVL +HLKRF   G   +K+   + FP E LDL+ +       +  +N    Y+L+
Sbjct: 1001 WKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYV------IGPKNNLKKYNLF 1054

Query: 746  GVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVP 805
             V  H G +  GHYTAY K                        ++ +WF   D  V  + 
Sbjct: 1055 SVSNHYGGLDGGHYTAYCK----------------------NAARQRWFKFDDHEVSDIS 1092

Query: 806  TTKVLNSQAYLLFY 819
             + V +S AY+LFY
Sbjct: 1093 VSSVKSSAAYILFY 1106



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 53/194 (27%), Positives = 88/194 (45%), Gaps = 16/194 (8%)

Query: 197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 256
           GL NLGNTC+ N+++Q L   P L +          I +               L   G 
Sbjct: 778 GLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNL------------LGHKGE 825

Query: 257 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 316
           +       +  +   +   ++PK+    + K   +F GY QQDSQELL +L+DG+  + +
Sbjct: 826 VAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLN 885

Query: 317 QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSM-PSFVDRIFGGELTSMIMCDQCRTV 375
           +  ++   K   N  + LD + K     ++K K +  S +  +F G+  S + C  C   
Sbjct: 886 KADNRKRYKEENN--DHLD-DFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKK 942

Query: 376 SLVHESFLDLSLPV 389
           S   E+F+ LSLP+
Sbjct: 943 SRTFEAFMYLSLPL 956



 Score = 33.9 bits (76), Expect = 0.63
 Identities = 15/87 (17%), Positives = 43/87 (49%)

Query: 396 KKSVNDKNLKKTVEDEDQDSEEEKDNDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQR 455
           +K+  +K L++  ++E ++   +++ +   K++ +         Q+KAK++ +K+   Q 
Sbjct: 474 EKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQA 533

Query: 456 RQQKIQGKVLHLNDICTIDHPEDSEYE 482
           +++  +       +I  +     SE+E
Sbjct: 534 KKEDKETSAKRGKEITGVKRQSKSEHE 560


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 46/194 (23%)

Query: 627  NTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLI 686
            +T +C++Q CL  F++ EKL D N+  C  C  R+                 ++ K++ I
Sbjct: 958  STSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR-----------------DSLKKIEI 1000

Query: 687  SLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLY 745
               PPVL +HLKRF   G   +K+   + FP E LDL+ +       +  +N    Y+L+
Sbjct: 1001 WKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYV------IGPKNNLKKYNLF 1054

Query: 746  GVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVP 805
             V  H G +  GHYTAY K                        ++ +WF   D  V  + 
Sbjct: 1055 SVSNHYGGLDGGHYTAYCK----------------------NAARQRWFKFDDHEVSDIS 1092

Query: 806  TTKVLNSQAYLLFY 819
             + V +S AY+LFY
Sbjct: 1093 VSSVKSSAAYILFY 1106



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 53/194 (27%), Positives = 88/194 (45%), Gaps = 16/194 (8%)

Query: 197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 256
           GL NLGNTC+ N+++Q L   P L +          I +               L   G 
Sbjct: 778 GLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNL------------LGHKGE 825

Query: 257 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 316
           +       +  +   +   ++PK+    + K   +F GY QQDSQELL +L+DG+  + +
Sbjct: 826 VAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLN 885

Query: 317 QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSM-PSFVDRIFGGELTSMIMCDQCRTV 375
           +  ++   K   N  + LD + K     ++K K +  S +  +F G+  S + C  C   
Sbjct: 886 KADNRKRYKEENN--DHLD-DFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKK 942

Query: 376 SLVHESFLDLSLPV 389
           S   E+F+ LSLP+
Sbjct: 943 SRTFEAFMYLSLPL 956



 Score = 33.9 bits (76), Expect = 0.63
 Identities = 15/87 (17%), Positives = 43/87 (49%)

Query: 396 KKSVNDKNLKKTVEDEDQDSEEEKDNDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQR 455
           +K+  +K L++  ++E ++   +++ +   K++ +         Q+KAK++ +K+   Q 
Sbjct: 474 EKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQA 533

Query: 456 RQQKIQGKVLHLNDICTIDHPEDSEYE 482
           +++  +       +I  +     SE+E
Sbjct: 534 KKEDKETSAKRGKEITGVKRQSKSEHE 560


>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
          Length = 963

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 67/233 (28%), Positives = 107/233 (45%), Gaps = 16/233 (6%)

Query: 157 IELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQ 216
           I +E +K +    + Q      NM++E+       Q  + GL+NLGNTCF N+ +Q LS 
Sbjct: 272 IIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKG--QPGICGLTNLGNTCFMNSALQCLSN 329

Query: 217 TPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVV 276
            P L E          +      +L    PL +     G +  A +  + +        +
Sbjct: 330 VPQLTEYF--------LNNCYLEELNFRNPLGMK----GEIAEAYADLVKQAWSGHHRSI 377

Query: 277 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDE 336
            P    ++V   A +F GYQQ DSQELL +LLDG+  E+  RV K       ++  + D+
Sbjct: 378 VPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLH-EDLNRVKKKEYVELCDAAGRPDQ 436

Query: 337 ELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
           E+  +     K+++    VD  F G   S ++C  C  VS+  + F  LS+P+
Sbjct: 437 EVAQEAWQNHKRRNDSVIVD-TFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 488



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 42/190 (22%)

Query: 633 IQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPV 692
           +Q C+  FT  E L   N   C  C + Q                  A K++ + + P +
Sbjct: 781 LQECIELFTTVETLEKENPWYCPSCKQHQL-----------------ATKKLDLWMLPEI 823

Query: 693 LTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVL-YSLYGVVEHS 751
           L +HLKRF    F+  K++  ++FP I DL  F     +   E N  +  Y L  V  H 
Sbjct: 824 LIIHLKRFSYTKFSREKLDTLVEFP-IRDL-DFSEFVIQPQNESNPELYKYDLIAVSNHY 881

Query: 752 GTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLN 811
           G MR GHYT +A  +                        GQW +  D  V  V   ++ +
Sbjct: 882 GGMRDGHYTTFACNK----------------------DSGQWHYFDDNSVSPVNENQIES 919

Query: 812 SQAYLLFYER 821
             AY+LFY+R
Sbjct: 920 KAAYVLFYQR 929


>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
          Length = 438

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 55/199 (27%), Positives = 80/199 (40%), Gaps = 49/199 (24%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           ++  CL +FTR E L  + K+ C  C                   Y  + KQ+ ++  P 
Sbjct: 262 TLTDCLRRFTRPEHLGSSAKIKCGSCQS-----------------YQESTKQLTMNKLPV 304

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKN---------VAEENTRVLY 742
           V   H KRF+ +    RK+  +I FP  LD+ PF     ++             N    Y
Sbjct: 305 VACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKY 364

Query: 743 SLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQ 802
           SL+ VV H GT+ SGHYT++ +                         K QWF   D  + 
Sbjct: 365 SLFAVVNHQGTLESGHYTSFIR-----------------------HHKDQWFKCDDAVIT 401

Query: 803 AVPTTKVLNSQAYLLFYER 821
                 VL+S+ YLLFY +
Sbjct: 402 KASIKDVLDSEGYLLFYHK 420



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 71/283 (25%), Positives = 110/283 (38%), Gaps = 68/283 (24%)

Query: 117 YVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQ---- 172
           YV D +++  +  + G+ +   + QAS +T           E+ +++       E+    
Sbjct: 5   YVYDKDIEQIAKEEQGEAL---KLQASTST-----------EVSHQQCSVPGLGEKFPTW 50

Query: 173 EREKKE-NMAKENPP---MNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVK 228
           E  K E  +   NP    + S   I ++GL NLGNTCF N ++Q L+ TP+LR+     +
Sbjct: 51  ETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDR 110

Query: 229 MSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKK 288
                 ++  P+L               L   MS    E+         P +L   V   
Sbjct: 111 HR---CEMPSPELC--------------LVCEMSSLFRELYSGNPSPHVPYKLLHLVWIH 153

Query: 289 AVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKK 348
           A    GY+QQD+ E L   LD +      R  KG                     D  K 
Sbjct: 154 ARHLAGYRQQDAHEFLIAALDVL-----HRHCKG--------------------DDVGKA 188

Query: 349 KSMPS----FVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSL 387
            + P+     +D+IF G L S + C  C  VS   +   D+SL
Sbjct: 189 ANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISL 231


>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 63/192 (32%), Positives = 91/192 (47%), Gaps = 34/192 (17%)

Query: 631 CSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAP 690
           C +   L +FT  E L +    +C+     QCN  +      +  V T A+KQ++I   P
Sbjct: 515 CLVTEMLAKFTETEAL-EGKIYVCD-----QCNSKRRRFSS-KPVVLTEAQKQLMICHLP 567

Query: 691 PVLTLHLKRFQQAGFNLR-KVNKHIKFPEILDLAPFCTLK-CKNVAEENTRVLYSLYGVV 748
            VL LHLKRF+ +G N R K+  H+ F EIL++ P+C  +  K++  E    +Y L  VV
Sbjct: 568 QVLRLHLKRFRWSGRNNREKIGVHVGFEEILNMEPYCCRETLKSLRPE--CFIYDLSAVV 625

Query: 749 EHSGT-MRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTT 807
            H G    SGHYTAY                      +  E  G W H +D+ +      
Sbjct: 626 MHHGKGFGSGHYTAYC---------------------YNSEG-GFWVHCNDSKLSMCTMD 663

Query: 808 KVLNSQAYLLFY 819
           +V  +QAY+LFY
Sbjct: 664 EVCKAQAYILFY 675



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 72/301 (23%), Positives = 116/301 (38%), Gaps = 74/301 (24%)

Query: 134 VVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQI 193
           +++ V  Q    TP    KD         K+   S+NE  ++  ++  K  P +      
Sbjct: 224 IIEIVSVQVPAQTPASPAKD---------KVLSTSENEISQKVSDSSVKRRPIVTPG--- 271

Query: 194 TVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIV--------KIEPPDLALTE 245
            V GL NLGNTC+ N+V+Q LS   + R+   ++ ++  +           + P +  T 
Sbjct: 272 -VTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTV 330

Query: 246 PLEIN---------------------------------LEPPGPLTLAMS------QFLN 266
             ++N                                 ++P  P +  +S          
Sbjct: 331 VYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQ 390

Query: 267 EMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKA 326
            M   K  +V+P  +   V +    F+GY QQD+QE L  LLD ++ E         L+ 
Sbjct: 391 VMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRE---------LET 441

Query: 327 FGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLS 386
            G S   L    + K+      K + + V+ IF G+L S + C  C   S   E F DLS
Sbjct: 442 TGTSLPALIPTSQRKL-----IKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLS 496

Query: 387 L 387
           L
Sbjct: 497 L 497



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 20/100 (20%)

Query: 24  CRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCLKCGHQGCG 83
           C+H+ + L+      +L   +W+ C DC T                S+W CL C H  CG
Sbjct: 7   CKHVGQ-LQLAQDHSSLNPQKWH-CVDCNTTE--------------SIWACLSCSHVACG 50

Query: 84  RNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV 123
           R   E+HALKH+   +   H + L ++   V+CY+CD+ V
Sbjct: 51  RYI-EEHALKHF---QESSHPVALEVNEMYVFCYLCDDYV 86


>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 63/192 (32%), Positives = 91/192 (47%), Gaps = 34/192 (17%)

Query: 631 CSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAP 690
           C +   L +FT  E L +    +C+     QCN  +      +  V T A+KQ++I   P
Sbjct: 515 CLVTEMLAKFTETEAL-EGKIYVCD-----QCNSKRRRFSS-KPVVLTEAQKQLMICHLP 567

Query: 691 PVLTLHLKRFQQAGFNLR-KVNKHIKFPEILDLAPFCTLK-CKNVAEENTRVLYSLYGVV 748
            VL LHLKRF+ +G N R K+  H+ F EIL++ P+C  +  K++  E    +Y L  VV
Sbjct: 568 QVLRLHLKRFRWSGRNNREKIGVHVGFEEILNMEPYCCRETLKSLRPE--CFIYDLSAVV 625

Query: 749 EHSGT-MRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTT 807
            H G    SGHYTAY                      +  E  G W H +D+ +      
Sbjct: 626 MHHGKGFGSGHYTAYC---------------------YNSEG-GFWVHCNDSKLSMCTMD 663

Query: 808 KVLNSQAYLLFY 819
           +V  +QAY+LFY
Sbjct: 664 EVCKAQAYILFY 675



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 72/301 (23%), Positives = 116/301 (38%), Gaps = 74/301 (24%)

Query: 134 VVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQI 193
           +++ V  Q    TP    KD         K+   S+NE  ++  ++  K  P +      
Sbjct: 224 IIEIVSVQVPAQTPASPAKD---------KVLSTSENEISQKVSDSSVKRRPIVTPG--- 271

Query: 194 TVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIV--------KIEPPDLALTE 245
            V GL NLGNTC+ N+V+Q LS   + R+   ++ ++  +           + P +  T 
Sbjct: 272 -VTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTV 330

Query: 246 PLEIN---------------------------------LEPPGPLTLAMS------QFLN 266
             ++N                                 ++P  P +  +S          
Sbjct: 331 VYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQ 390

Query: 267 EMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKA 326
            M   K  +V+P  +   V +    F+GY QQD+QE L  LLD ++ E         L+ 
Sbjct: 391 VMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRE---------LET 441

Query: 327 FGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLS 386
            G S   L    + K+      K + + V+ IF G+L S + C  C   S   E F DLS
Sbjct: 442 TGTSLPALIPTSQRKL-----IKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLS 496

Query: 387 L 387
           L
Sbjct: 497 L 497



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 20/100 (20%)

Query: 24  CRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCLKCGHQGCG 83
           C+H+ + L+      +L   +W+ C DC T                S+W CL C H  CG
Sbjct: 7   CKHVGQ-LQLAQDHSSLNPQKWH-CVDCNTTE--------------SIWACLSCSHVACG 50

Query: 84  RNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV 123
           R   E+HALKH+   +   H + L ++   V+CY+CD+ V
Sbjct: 51  RYI-EEHALKHF---QESSHPVALEVNEMYVFCYLCDDYV 86


>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 55/191 (28%), Positives = 81/191 (42%), Gaps = 45/191 (23%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           +++ CL  F   ++L+  N   CE C + +                 N  K   +   P 
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLR-----------------NGVKYCKVLRLPE 580

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLYGVVEH 750
           +L +HLKRF+       K+N H+ FP E LDL PF   +C +         Y L  V+ H
Sbjct: 581 ILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQI-----TTYDLLSVICH 635

Query: 751 SGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVL 810
            GT  SGHY AY +         N++              GQW+   D +V  V  T V 
Sbjct: 636 HGTAGSGHYIAYCQ---------NVI-------------NGQWYEFDDQYVTEVHETVVQ 673

Query: 811 NSQAYLLFYER 821
           N++ Y+LFY +
Sbjct: 674 NAEGYVLFYRK 684



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 70/279 (25%), Positives = 123/279 (44%), Gaps = 49/279 (17%)

Query: 69  PSVWLCLK--CGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV--- 123
           P++W CL+  C + GCG +  + H+  H    +++ H L ++L  + +WCY C+ EV   
Sbjct: 38  PNLWACLQVACPYVGCGESFAD-HSTIH---AQAKKHNLTVNLTTFRLWCYACEKEVFLE 93

Query: 124 QYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKE 183
           Q  ++  LG            ++ K +E+D+       K +     +E E E +++  K 
Sbjct: 94  QRLAAPLLG------------SSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLK- 140

Query: 184 NPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLAL 243
                 P  +T  G+ NLGN+C+ NA +Q LS  P L +   E    G +V+ +      
Sbjct: 141 ------PRGLT--GMKNLGNSCYMNAALQALSNCPPLTQFFLE---CGGLVRTDKKP--- 186

Query: 244 TEPLEINLEPPGPLTLAMSQFLNEMQETKK-GVVTPKELFSQVCKKAVRFKGYQQQDSQE 302
                        L  +  + ++E+   K+   V P  L   +      F+GY QQD+QE
Sbjct: 187 ------------ALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQE 234

Query: 303 LLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNK 341
            LR L+D +  E  + V   +       ++  D + K +
Sbjct: 235 FLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKRE 273



 Score = 37.0 bits (84), Expect = 0.075
 Identities = 17/43 (39%), Positives = 25/43 (58%)

Query: 347 KKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
           K++   S +  IF G + S++ C  C  VS   E+F DLSLP+
Sbjct: 437 KEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPI 479


>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 55/191 (28%), Positives = 81/191 (42%), Gaps = 45/191 (23%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           +++ CL  F   ++L+  N   CE C + +                 N  K   +   P 
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLR-----------------NGVKYCKVLRLPE 580

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLYGVVEH 750
           +L +HLKRF+       K+N H+ FP E LDL PF   +C +         Y L  V+ H
Sbjct: 581 ILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQI-----TTYDLLSVICH 635

Query: 751 SGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVL 810
            GT  SGHY AY +         N++              GQW+   D +V  V  T V 
Sbjct: 636 HGTAGSGHYIAYCQ---------NVI-------------NGQWYEFDDQYVTEVHETVVQ 673

Query: 811 NSQAYLLFYER 821
           N++ Y+LFY +
Sbjct: 674 NAEGYVLFYRK 684



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 70/279 (25%), Positives = 123/279 (44%), Gaps = 49/279 (17%)

Query: 69  PSVWLCLK--CGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV--- 123
           P++W CL+  C + GCG +  + H+  H    +++ H L ++L  + +WCY C+ EV   
Sbjct: 38  PNLWACLQVACPYVGCGESFAD-HSTIH---AQAKKHNLTVNLTTFRLWCYACEKEVFLE 93

Query: 124 QYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKE 183
           Q  ++  LG            ++ K +E+D+       K +     +E E E +++  K 
Sbjct: 94  QRLAAPLLG------------SSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLK- 140

Query: 184 NPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLAL 243
                 P  +T  G+ NLGN+C+ NA +Q LS  P L +   E    G +V+ +      
Sbjct: 141 ------PRGLT--GMKNLGNSCYMNAALQALSNCPPLTQFFLE---CGGLVRTDKKP--- 186

Query: 244 TEPLEINLEPPGPLTLAMSQFLNEMQETKK-GVVTPKELFSQVCKKAVRFKGYQQQDSQE 302
                        L  +  + ++E+   K+   V P  L   +      F+GY QQD+QE
Sbjct: 187 ------------ALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQE 234

Query: 303 LLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNK 341
            LR L+D +  E  + V   +       ++  D + K +
Sbjct: 235 FLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKRE 273



 Score = 37.0 bits (84), Expect = 0.075
 Identities = 17/43 (39%), Positives = 25/43 (58%)

Query: 347 KKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
           K++   S +  IF G + S++ C  C  VS   E+F DLSLP+
Sbjct: 437 KEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPI 479


>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 55/191 (28%), Positives = 81/191 (42%), Gaps = 45/191 (23%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           +++ CL  F   ++L+  N   CE C + +                 N  K   +   P 
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLR-----------------NGVKYCKVLRLPE 580

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLYGVVEH 750
           +L +HLKRF+       K+N H+ FP E LDL PF   +C +         Y L  V+ H
Sbjct: 581 ILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQI-----TTYDLLSVICH 635

Query: 751 SGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVL 810
            GT  SGHY AY +         N++              GQW+   D +V  V  T V 
Sbjct: 636 HGTAGSGHYIAYCQ---------NVI-------------NGQWYEFDDQYVTEVHETVVQ 673

Query: 811 NSQAYLLFYER 821
           N++ Y+LFY +
Sbjct: 674 NAEGYVLFYRK 684



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 70/279 (25%), Positives = 123/279 (44%), Gaps = 49/279 (17%)

Query: 69  PSVWLCLK--CGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV--- 123
           P++W CL+  C + GCG +  + H+  H    +++ H L ++L  + +WCY C+ EV   
Sbjct: 38  PNLWACLQVACPYVGCGESFAD-HSTIH---AQAKKHNLTVNLTTFRLWCYACEKEVFLE 93

Query: 124 QYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKE 183
           Q  ++  LG            ++ K +E+D+       K +     +E E E +++  K 
Sbjct: 94  QRLAAPLLG------------SSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDLK- 140

Query: 184 NPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLAL 243
                 P  +T  G+ NLGN+C+ NA +Q LS  P L +   E    G +V+ +      
Sbjct: 141 ------PRGLT--GMKNLGNSCYMNAALQALSNCPPLTQFFLE---CGGLVRTDKKP--- 186

Query: 244 TEPLEINLEPPGPLTLAMSQFLNEMQETKK-GVVTPKELFSQVCKKAVRFKGYQQQDSQE 302
                        L  +  + ++E+   K+   V P  L   +      F+GY QQD+QE
Sbjct: 187 ------------ALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQE 234

Query: 303 LLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNK 341
            LR L+D +  E  + V   +       ++  D + K +
Sbjct: 235 FLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKRE 273



 Score = 37.0 bits (84), Expect = 0.075
 Identities = 17/43 (39%), Positives = 25/43 (58%)

Query: 347 KKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
           K++   S +  IF G + S++ C  C  VS   E+F DLSLP+
Sbjct: 437 KEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPI 479


>gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo
           sapiens]
          Length = 530

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 58/190 (30%), Positives = 87/190 (45%), Gaps = 51/190 (26%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           S+Q  L Q  + E+L   N   C VC +R                   A K + +  +  
Sbjct: 232 SVQQALEQLVKPEELNGENAYHCGVCLQR-----------------APASKTLTLHTSAK 274

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVL-YSLYGVVEH 750
           VL L LKRF     N  K+ K++++PE LD+ P+       ++++NT  L Y LY V+ H
Sbjct: 275 VLILVLKRFSDVTGN--KIAKNVQYPECLDMQPY-------MSQQNTGPLVYVLYAVLVH 325

Query: 751 SG-TMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809
           +G +  +GHY +Y KA+                       +GQW+ + D  V A   T V
Sbjct: 326 AGWSCHNGHYFSYVKAQ-----------------------EGQWYKMDDAEVTAASITSV 362

Query: 810 LNSQAYLLFY 819
           L+ QAY+LFY
Sbjct: 363 LSQQAYVLFY 372



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 54/236 (22%), Positives = 96/236 (40%), Gaps = 52/236 (22%)

Query: 182 KENPPMNSPCQITV-KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD 240
           +E  P++S     V  GL N+GNTC+ NA +Q L+ TP L   +   + S T  + +   
Sbjct: 65  REKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHK--- 121

Query: 241 LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS 300
                         G +   M   +         V+ P +        A  F   +Q+D+
Sbjct: 122 --------------GCMLCTMQAHITRALHNPGHVIQPSQAL------AAGFHRGKQEDA 161

Query: 301 QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG 360
            E L + +D M+            KA     +++D   K+            + + +IFG
Sbjct: 162 HEFLMFTVDAMK------------KACLPGHKQVDHHSKD-----------TTLIHQIFG 198

Query: 361 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSE 416
           G   S I C  C  +S   + +LD++L +   QS +++     L++ V+ E+ + E
Sbjct: 199 GYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQA-----LEQLVKPEELNGE 249


>gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo
           sapiens]
          Length = 530

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 58/190 (30%), Positives = 87/190 (45%), Gaps = 51/190 (26%)

Query: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
           S+Q  L Q  + E+L   N   C VC +R                   A K + +  +  
Sbjct: 232 SVQQALEQLVKPEELNGENAYHCGVCLQR-----------------APASKTLTLHTSAK 274

Query: 692 VLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVL-YSLYGVVEH 750
           VL L LKRF     N  K+ K++++PE LD+ P+       ++++NT  L Y LY V+ H
Sbjct: 275 VLILVLKRFSDVTGN--KIAKNVQYPECLDMQPY-------MSQQNTGPLVYVLYAVLVH 325

Query: 751 SG-TMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKV 809
           +G +  +GHY +Y KA+                       +GQW+ + D  V A   T V
Sbjct: 326 AGWSCHNGHYFSYVKAQ-----------------------EGQWYKMDDAEVTAASITSV 362

Query: 810 LNSQAYLLFY 819
           L+ QAY+LFY
Sbjct: 363 LSQQAYVLFY 372



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 55/243 (22%), Positives = 99/243 (40%), Gaps = 52/243 (21%)

Query: 175 EKKENMAKENPPMNSPCQITV-KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTI 233
           E ++   +E  P++S     V  GL N+GNTC+ NA +Q L+ TP L   +   + S T 
Sbjct: 58  EARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTC 117

Query: 234 VKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFK 293
            + +                 G +   M   +         V+ P +        A  F 
Sbjct: 118 HRHK-----------------GCMLCTMQAHITRALHNPGHVIQPSQAL------AAGFH 154

Query: 294 GYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPS 353
             +Q+D+ E L + +D M+            KA     +++D   K+            +
Sbjct: 155 RGKQEDAHEFLMFTVDAMK------------KACLPGHKQVDHPSKD-----------TT 191

Query: 354 FVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQ 413
            + +IFGG   S I C  C  +S   + +LD++L +   QS +++     L++ V+ E+ 
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQA-----LEQLVKPEEL 246

Query: 414 DSE 416
           + E
Sbjct: 247 NGE 249


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,867,188
Number of Sequences: 37866
Number of extensions: 1580152
Number of successful extensions: 10710
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 163
Number of HSP's successfully gapped in prelim test: 260
Number of HSP's that attempted gapping in prelim test: 8485
Number of HSP's gapped (non-prelim): 1928
length of query: 823
length of database: 18,247,518
effective HSP length: 111
effective length of query: 712
effective length of database: 14,044,392
effective search space: 9999607104
effective search space used: 9999607104
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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