Guide to the Human Genome
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Search of human proteins with 5453832

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens]
         (999 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens]         1955   0.0  
gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens]           1955   0.0  
gi|38327039 heat shock 70kDa protein 4 [Homo sapiens]                 314   2e-85
gi|42544159 heat shock 105kD [Homo sapiens]                           314   2e-85
gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]            304   2e-82
gi|34419635 heat shock 70kDa protein 6 (HSP70B') [Homo sapiens]       229   7e-60
gi|5729877 heat shock 70kDa protein 8 isoform 1 [Homo sapiens]        227   5e-59
gi|24234686 heat shock 70kDa protein 8 isoform 2 [Homo sapiens]       222   2e-57
gi|167466173 heat shock 70kDa protein 1B [Homo sapiens]               222   2e-57
gi|194248072 heat shock 70kDa protein 1A [Homo sapiens]               222   2e-57
gi|124256496 heat shock 70kDa protein 1-like [Homo sapiens]           219   8e-57
gi|13676857 heat shock 70kDa protein 2 [Homo sapiens]                 215   2e-55
gi|16507237 heat shock 70kDa protein 5 [Homo sapiens]                 207   5e-53
gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens]       168   3e-41
gi|82880658 heat shock 70kDa protein 14 isoform 1 [Homo sapiens]      154   5e-37
gi|48928056 heat shock protein 70kDa family member 13 precursor ...   137   5e-32
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     60   8e-09
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              54   6e-07
gi|70980549 programmed cell death 11 [Homo sapiens]                    53   2e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    51   5e-06
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    51   5e-06
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       50   1e-05
gi|225543215 antigen identified by monoclonal antibody Ki-67 iso...    48   5e-05
gi|103472005 antigen identified by monoclonal antibody Ki-67 iso...    48   5e-05
gi|24308394 hypothetical protein LOC140893 [Homo sapiens]              47   7e-05
gi|20270186 high mobility group nucleosomal binding domain 3 iso...    47   9e-05
gi|33286446 opioid growth factor receptor [Homo sapiens]               47   1e-04
gi|58082089 hypothetical protein LOC161394 [Homo sapiens]              47   1e-04
gi|186700623 Rab-like GTP-binding protein 1 isoform 1 [Homo sapi...    46   2e-04
gi|14141161 heterogeneous nuclear ribonucleoprotein U isoform b ...    46   2e-04

>gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens]
          Length = 999

 Score = 1955 bits (5065), Expect = 0.0
 Identities = 999/999 (100%), Positives = 999/999 (100%)

Query: 1   MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL 60
           MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL
Sbjct: 1   MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL 60

Query: 61  NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF 120
           NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF
Sbjct: 61  NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF 120

Query: 121 PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF 180
           PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF
Sbjct: 121 PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF 180

Query: 181 NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC 240
           NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC
Sbjct: 181 NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC 240

Query: 241 TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR 300
           TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR
Sbjct: 241 TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR 300

Query: 301 ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP 360
           ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP
Sbjct: 301 ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP 360

Query: 361 GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420
           GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV
Sbjct: 361 GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420

Query: 421 YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK 480
           YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK
Sbjct: 421 YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK 480

Query: 481 VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK 540
           VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK
Sbjct: 481 VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK 540

Query: 541 AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT 600
           AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT
Sbjct: 541 AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT 600

Query: 601 VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK 660
           VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK
Sbjct: 601 VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK 660

Query: 661 SEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV 720
           SEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV
Sbjct: 661 SEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV 720

Query: 721 QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST 780
           QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST
Sbjct: 721 QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST 780

Query: 781 WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR 840
           WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR
Sbjct: 781 WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR 840

Query: 841 LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR 900
           LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR
Sbjct: 841 LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR 900

Query: 901 EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV 960
           EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV
Sbjct: 901 EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV 960

Query: 961 ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL 999
           ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL
Sbjct: 961 ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL 999


>gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens]
          Length = 999

 Score = 1955 bits (5065), Expect = 0.0
 Identities = 999/999 (100%), Positives = 999/999 (100%)

Query: 1   MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL 60
           MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL
Sbjct: 1   MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL 60

Query: 61  NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF 120
           NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF
Sbjct: 61  NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF 120

Query: 121 PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF 180
           PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF
Sbjct: 121 PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF 180

Query: 181 NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC 240
           NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC
Sbjct: 181 NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC 240

Query: 241 TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR 300
           TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR
Sbjct: 241 TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR 300

Query: 301 ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP 360
           ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP
Sbjct: 301 ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP 360

Query: 361 GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420
           GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV
Sbjct: 361 GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420

Query: 421 YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK 480
           YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK
Sbjct: 421 YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK 480

Query: 481 VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK 540
           VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK
Sbjct: 481 VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK 540

Query: 541 AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT 600
           AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT
Sbjct: 541 AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT 600

Query: 601 VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK 660
           VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK
Sbjct: 601 VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK 660

Query: 661 SEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV 720
           SEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV
Sbjct: 661 SEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV 720

Query: 721 QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST 780
           QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST
Sbjct: 721 QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST 780

Query: 781 WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR 840
           WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR
Sbjct: 781 WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR 840

Query: 841 LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR 900
           LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR
Sbjct: 841 LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR 900

Query: 901 EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV 960
           EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV
Sbjct: 901 EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV 960

Query: 961 ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL 999
           ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL
Sbjct: 961 ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL 999


>gi|38327039 heat shock 70kDa protein 4 [Homo sapiens]
          Length = 840

 Score =  314 bits (805), Expect = 2e-85
 Identities = 257/939 (27%), Positives = 425/939 (45%), Gaps = 116/939 (12%)

Query: 33  LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKN 92
           ++V+ +DLG +S  VA+ + G  +E + N+ S R TP  ++     R  G +A S  I N
Sbjct: 1   MSVVGIDLGFQSCYVAVARAG-GIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISN 59

Query: 93  PKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQ-ISSQLQFSPEEVLG 151
            K T++ F+   G+   +P V   ++      +        +    +  +  F+ E+V  
Sbjct: 60  AKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTA 119

Query: 152 MVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATAL 211
           M+L+  +  AE   ++P+ D V++VP F+  AERR+V+ A ++AGL  L+L+N+ TA AL
Sbjct: 120 MLLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVAL 179

Query: 212 SYGVFRR--KDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRT 269
           +YG++++    +    +N++F DMG  +   ++  +   K         L++    FD T
Sbjct: 180 AYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGK---------LKVLATAFDTT 230

Query: 270 LGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANA-DHMA 328
           LGG + +    E L   F E+   +   D++   RA+ +L +E  +LK ++SANA D   
Sbjct: 231 LGGRKFD----EVLVNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPL 286

Query: 329 QIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATR 388
            IE  M+DVD    + R +F E+C DL  RV  P++  L+  ++  ++I  V +VGGATR
Sbjct: 287 SIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATR 346

Query: 389 VPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVE 448
           +P V+E + K  GK EL   +NADEA   G   Q A LS AFKV+ F + D V YPI + 
Sbjct: 347 IPAVKEKISKFFGK-ELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLR 405

Query: 449 FTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYG---DLGFLGP 505
           +    EE         +   +FS+    P  KV+TF R    F     Y    DL +  P
Sbjct: 406 WNSPAEE-------GSSDCEVFSKNHAAPFSKVLTFYR-KEPFTLEAYYSSPQDLPYPDP 457

Query: 506 EDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVE 565
             +  F  Q +T               D  S  +K    ++  G+ S+        +LVE
Sbjct: 458 A-IAQFSVQKVT------------PQSDGSSSKVKVKVRVNVHGIFSVSSA-----SLVE 499

Query: 566 DSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEE 625
               EE+                              EE     + +K+E   QV   ++
Sbjct: 500 VHKSEEN------------------------------EEPMETDQNAKEEEKMQV---DQ 526

Query: 626 AEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEK 685
            E  VE+  Q  P E K           E E  + S+A    +K +              
Sbjct: 527 EEPHVEEQQQQTPAENK----------AESEEMETSQAGSKDKKMD-------------- 562

Query: 686 KQKPARKRRMVEEIGVELVVLD--LPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSL 743
            Q P  K+  V+   V+L + +  L  +  + L   ++    + ++D  ++ER  A N++
Sbjct: 563 -QPPQAKKAKVKTSTVDLPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAV 621

Query: 744 EAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRK 803
           E +++E +DKL   EY++  +E+ R   + KL     WL ++G      +  +KLAEL+ 
Sbjct: 622 EEYVYEMRDKL-SGEYEKFVSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKN 680

Query: 804 LCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINE 863
           L Q +  R +E ++ P+    L   +      +   +   +        +MT +EK  NE
Sbjct: 681 LGQPIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKEDQYDHLDAADMTKVEKSTNE 740

Query: 864 TWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNG 923
              W N  L  Q K   T  PV+ SK+IEAK+  L      +++K K     P+ + KN 
Sbjct: 741 AMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKELTSTCSPIISKPKPKVEPPKEEQKNA 800

Query: 924 TRAEPPLNASASDQGEKVIPPAGQ--TEDAEPISEPEKV 960
            +     N     QG+   P A +  T+ A P    +K+
Sbjct: 801 EQ-----NGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKL 834


>gi|42544159 heat shock 105kD [Homo sapiens]
          Length = 858

 Score =  314 bits (805), Expect = 2e-85
 Identities = 256/934 (27%), Positives = 437/934 (46%), Gaps = 132/934 (14%)

Query: 33  LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKN 92
           ++V+ +D+GS+S  +A+ + G  +E + N+ S R TP +++     R  G +A +  I +
Sbjct: 1   MSVVGLDVGSQSCYIAVARAG-GIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITH 59

Query: 93  PKATLRYFQHLLGKQADNPHVALYQARFPEHELTFD--PQRQ-----TVHFQISSQLQFS 145
              T+  F+   G+  ++P +     +  +  L++D  P +       V +     L FS
Sbjct: 60  ANNTVSNFKRFHGRAFNDPFI-----QKEKENLSYDLVPLKNGGVGIKVMYMGEEHL-FS 113

Query: 146 PEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLIND 205
            E++  M+L   +  AE+  ++P+ D VI+VP FF  AERR+VL AA++ GL  L+L+ND
Sbjct: 114 VEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMND 173

Query: 206 NTATALSYGVFRR--KDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRG 263
            TA AL+YG++++    ++   + ++F DMG  +   +   +   K         L++ G
Sbjct: 174 MTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGK---------LKVLG 224

Query: 264 VGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSAN 323
             FD  LGG   + +L E     F  + K     D +   RA+ +L +E  +LK ++S+N
Sbjct: 225 TAFDPFLGGKNFDEKLVEHFCAEFKTKYK----LDAKSKIRALLRLYQECEKLKKLMSSN 280

Query: 324 A-DHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVIL 382
           + D    IE  M+D D   K+ R +FEELCA+L +++  P+   L+   + ++++  V +
Sbjct: 281 STDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEI 340

Query: 383 VGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVV 442
           VGGATR+P V+E + K  GK ++   +NADEA A G   Q A LS AFKV+ F V DAV 
Sbjct: 341 VGGATRIPAVKERIAKFFGK-DISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVP 399

Query: 443 YPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGD-LG 501
           +PI + +  + E+  G+H        +FSR    P  KV+TF R    F     Y D  G
Sbjct: 400 FPISLIWNHDSEDTEGVHE-------VFSRNHAAPFSKVLTFLRRG-PFELEAFYSDPQG 451

Query: 502 FLGPE-DLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVF 560
              PE  +  F  QN++  K            D E   +K    ++  G+ ++       
Sbjct: 452 VPYPEAKIGRFVVQNVSAQK------------DGEKSRVKVKVRVNTHGIFTISTA---- 495

Query: 561 ETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQV 620
            ++VE    EE+ ++   +           PD  +N    VQ++          E G Q 
Sbjct: 496 -SMVEKVPTEENEMSSEADMECLNQRPPENPDTDKN----VQQD--------NSEAGTQP 542

Query: 621 ELKEEAEAPVEDGSQPPPPE--PKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVA 678
           +++ +A+   +    PP PE   + +  P+ +KA EK+     EA+KP            
Sbjct: 543 QVQTDAQ---QTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPK----------- 588

Query: 679 PAPEGEKKQKPARKRRMVEEIGVELVVLD--LPDLPEDKLAQSVQKLQDLTLRDLEKQER 736
                            ++ + VEL +    +  L +D L   ++    + ++D  ++ER
Sbjct: 589 -----------------IKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKER 631

Query: 737 EKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE 796
             A N++E +++E +DKL  P Y++   E+  +     L+    WL +EG         +
Sbjct: 632 NDAKNAVEEYVYEFRDKLCGP-YEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVD 690

Query: 797 KLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTT 856
           KL EL K+   +  R +E ++ P+    L   L H +      R   E      E EM  
Sbjct: 691 KLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKK 750

Query: 857 LEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRP 916
           +EK +NE   W N  +  QAK    + PV+ +++I+ K+  L+   + ++     T+P+P
Sbjct: 751 VEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVV-----TQPKP 805

Query: 917 R---PK------------------DKNGTRAEPP 929
           +   PK                  DKN   AEPP
Sbjct: 806 KIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPP 839


>gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]
          Length = 839

 Score =  304 bits (779), Expect = 2e-82
 Identities = 238/911 (26%), Positives = 422/911 (46%), Gaps = 100/911 (10%)

Query: 33  LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKN 92
           ++V+ +DLG  +  +A+ + G  +E + N+ S R TP  ++L    R  G++A S  + N
Sbjct: 1   MSVVGIDLGFLNCYIAVARSG-GIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTN 59

Query: 93  PKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQT---VHFQISSQLQFSPEEV 149
            + T+  F+ L G+  D+P V   + R P +EL   P       V + +  +  F+ E+V
Sbjct: 60  VRNTIHGFKKLHGRSFDDPIVQTERIRLP-YELQKMPNGSAGVKVRY-LEEERPFAIEQV 117

Query: 150 LGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTAT 209
            GM+L   +  +E+  ++P+ D VI++P FF  AERR+V+ AA++AGL  L+L+N+ TA 
Sbjct: 118 TGMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAV 177

Query: 210 ALSYGVFRR--KDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFD 267
           AL+YG++++    ++   +N++F DMG  +    +  +   K         L++    FD
Sbjct: 178 ALAYGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGK---------LKVLATTFD 228

Query: 268 RTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANA-DH 326
             LGG   +    E L   F ++ K +   +V+EN RA+ +L +E  +LK ++SANA D 
Sbjct: 229 PYLGGRNFD----EALVDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDL 284

Query: 327 MAQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGA 386
              IE  M+D+D  +K+ R +FE+LCA L  RV  P++  ++ A +  ++I  + +VGGA
Sbjct: 285 PLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGA 344

Query: 387 TRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPIL 446
           TR+P V+E + K   K ++   +NADEA A G   Q A LS AFKV+ F + D V Y I 
Sbjct: 345 TRIPAVKEQITKFFLK-DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSIT 403

Query: 447 VEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPE 506
           + +    E+  G       +  +F +  P P  KVITF++    F     Y +L  +   
Sbjct: 404 LRWKTSFEDGSG-------ECEVFCKNHPAPFSKVITFHK-KEPFELEAFYTNLHEVPYP 455

Query: 507 DLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVED 566
           D R+ GS  +  V  +  GDS K         +K    ++  G+ S+     + +  +E 
Sbjct: 456 DARI-GSFTIQNVFPQSDGDSSK---------VKVKVRVNIHGIFSVASASVIEKQNLEG 505

Query: 567 SAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEA 626
                                               +  ++P E       E  +  ++ 
Sbjct: 506 ------------------------------------DHSDAPMETETSFKNENKDNMDKM 529

Query: 627 EAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKK 686
           +   E+G Q    +   + TPE                   E    G +  +   + + +
Sbjct: 530 QVDQEEGHQ----KCHAEHTPE------------------EEIDHTGAKTKSAVSDKQDR 567

Query: 687 QKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAF 746
                K+  V+ I + +       L +D L   ++    + ++D  ++ER  A N++E +
Sbjct: 568 LNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEY 627

Query: 747 IFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQ 806
           +++ +D+L    Y++  T E   ++S  L     WL ++G      +  +KL EL+K  Q
Sbjct: 628 VYDFRDRL-GTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQ 686

Query: 807 GLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWA 866
            +  +  E ++ P+ L+ L   +      ++  R   E        EM  +EK I++  +
Sbjct: 687 PIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMS 746

Query: 867 WKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRA 926
           W N+ +  Q KL  T+ PV+   +I AK   LD     ++ K K     P  K K  +  
Sbjct: 747 WLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDNFCNPIIYKPKPKAEVPEDKPKANSEH 806

Query: 927 EPPLNASASDQ 937
             P++  +  +
Sbjct: 807 NGPMDGQSGTE 817


>gi|34419635 heat shock 70kDa protein 6 (HSP70B') [Homo sapiens]
          Length = 643

 Score =  229 bits (585), Expect = 7e-60
 Identities = 183/620 (29%), Positives = 295/620 (47%), Gaps = 63/620 (10%)

Query: 36  MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKA 95
           + +DLG+    V + + G  +EI+ N +  R TP  V   + ER  GD+A S A  NP  
Sbjct: 9   VGIDLGTTYSCVGVFQQG-RVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHN 67

Query: 96  TLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLN 155
           T+   + L+G++  +  V      +P   ++   + +           F PEE+  MVL+
Sbjct: 68  TVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLS 127

Query: 156 YSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGV 215
             +  AE +  QP+K AVITVP +FN ++R+A   A  +AGL VL++IN+ TA A++YG+
Sbjct: 128 KMKETAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGL 187

Query: 216 FRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEM 275
            RR       +N++ +D+G G+   ++++       +AG+    +++    D  LGG + 
Sbjct: 188 DRR---GAGERNVLIFDLGGGTFDVSVLSI------DAGV---FEVKATAGDTHLGGEDF 235

Query: 276 ELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMD 335
           +     RL   F E+ + +  KD+  N RA+ +L     R K  LS++     +I+ L +
Sbjct: 236 D----NRLVNHFMEEFRRKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFE 291

Query: 336 DVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEV 395
            VDF   +TR  FEELC+DLF     PV++AL+ A++   +I  V+LVGG+TR+P+VQ++
Sbjct: 292 GVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKL 351

Query: 396 LLKAVGKEELGKNINADEAAAMGAVYQAAAL--SKAFKVKPFVVRDAVVYPILVEFTREV 453
           L      +EL K+IN DEA A GA  QAA L   K  KV+  ++ D  V P+ +      
Sbjct: 352 LQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLLD--VAPLSL------ 403

Query: 454 EEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGS 513
               G+ +       L  R    P ++  TF  YS       N   +     E  R    
Sbjct: 404 ----GLETAGGVMTTLIQRNATIPTKQTQTFTTYSD------NQPGVFIQVYEGERAMTK 453

Query: 514 QN--LTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEE 571
            N  L   +L G+  + +  P      I+  F++D +G+LS+        T  + S  + 
Sbjct: 454 DNNLLGRFELSGIPPAPRGVPQ-----IEVTFDIDANGILSV--------TATDRSTGKA 500

Query: 572 STLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVE 631
           + +T + N    L        +KE     V E E+  AE       ++V  K   EA V 
Sbjct: 501 NKIT-ITNDKGRL--------SKEEVERMVHEAEQYKAEDEAQR--DRVAAKNSLEAHVF 549

Query: 632 DGSQPPPPEPKGDATPEGEK 651
                   E   D  PE ++
Sbjct: 550 HVKGSLQEESLRDKIPEEDR 569



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 56/273 (20%), Positives = 106/273 (38%), Gaps = 45/273 (16%)

Query: 547 ESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEE 606
           ++ VL  D+ E V + L+ D A     L   G  +++L     T   K+  T T      
Sbjct: 378 QAAVLMGDKCEKVQDLLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTY---- 433

Query: 607 SPAEGSKDEPGEQVELKEEAEAPVEDGS-------QPPPPEPKGDATPEGEKATEKENGD 659
                S ++PG  +++ E   A  +D +          PP P+G   P+ E   + +   
Sbjct: 434 -----SDNQPGVFIQVYEGERAMTKDNNLLGRFELSGIPPAPRG--VPQIEVTFDID--- 483

Query: 660 KSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQS 719
                           G+      ++    A K  +  + G          L ++++ + 
Sbjct: 484 --------------ANGILSVTATDRSTGKANKITITNDKG---------RLSKEEVERM 520

Query: 720 VQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAS 779
           V + +     D  +++R  A NSLEA +F  +  L +   ++   EE R ++  K     
Sbjct: 521 VHEAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVL 580

Query: 780 TWLEDEGVGATTVMLKEKLAELRKLCQGLFFRV 812
            WLE   + A     + +  EL ++C+ +F R+
Sbjct: 581 AWLEHNQL-AEKEEYEHQKRELEQICRPIFSRL 612


>gi|5729877 heat shock 70kDa protein 8 isoform 1 [Homo sapiens]
          Length = 646

 Score =  227 bits (578), Expect = 5e-59
 Identities = 174/599 (29%), Positives = 291/599 (48%), Gaps = 67/599 (11%)

Query: 36  MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKA 95
           + +DLG+    V + + G  +EI+ N +  R TP  V   + ER  GD+A +    NP  
Sbjct: 7   VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65

Query: 96  TLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQ-FSPEEVLGMVL 154
           T+   + L+G++ D+  V      +P   +  D  R  V  +   + + F PEEV  MVL
Sbjct: 66  TVFDAKRLIGRRFDDAVVQSDMKHWP-FMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVL 124

Query: 155 NYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYG 214
              + +AE +  + + +AV+TVP +FN ++R+A   A  +AGL VL++IN+ TA A++YG
Sbjct: 125 TKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYG 184

Query: 215 VFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLE 274
           + ++       +N++ +D+G G+   +I+T       E G+    +++    D  LGG +
Sbjct: 185 LDKKVGAE---RNVLIFDLGGGTFDVSILTI------EDGI---FEVKSTAGDTHLGGED 232

Query: 275 MELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLM 334
            + R+       F  + K    KD+ EN RA+ +L     R K  LS++     +I+ L 
Sbjct: 233 FDNRMVNHFIAEFKRKHK----KDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLY 288

Query: 335 DDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQE 394
           + +DF   +TR  FEEL ADLF     PV++AL+ A++   +I  ++LVGG+TR+P++Q+
Sbjct: 289 EGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQK 348

Query: 395 VLLKAVGKEELGKNINADEAAAMGAVYQAAALS--KAFKVKPFVVRDAVVYPILVEFTRE 452
           +L      +EL K+IN DEA A GA  QAA LS  K+  V+  ++ D  V P+ +     
Sbjct: 349 LLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLD--VTPLSL----- 401

Query: 453 VEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHD---FNFHINYGDLGFLGPEDLR 509
                GI +      VL  R    P ++  TF  YS +       +  G+       +L 
Sbjct: 402 -----GIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL- 455

Query: 510 VFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAE 569
                 L   +L G+  + +  P      I+  F++D +G+L++  V+           E
Sbjct: 456 ------LGKFELTGIPPAPRGVPQ-----IEVTFDIDANGILNVSAVDK------STGKE 498

Query: 570 EESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEA 628
            + T+T     +S           KE+    VQE E+  AE  K    ++V  K   E+
Sbjct: 499 NKITITNDKGRLS-----------KEDIERMVQEAEKYKAEDEKQR--DKVSSKNSLES 544



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 51/273 (18%), Positives = 106/273 (38%), Gaps = 45/273 (16%)

Query: 547 ESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEE 606
           ++ +LS D+ E+V + L+ D       +   G  ++ L    TT   K+  T T      
Sbjct: 376 QAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTY---- 431

Query: 607 SPAEGSKDEPGEQVELKEEAEAPVEDGS-------QPPPPEPKGDATPEGEKATEKENGD 659
                S ++PG  +++ E   A  +D +          PP P+G   P+ E   + +   
Sbjct: 432 -----SDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRG--VPQIEVTFDID--- 481

Query: 660 KSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQS 719
                           G+      +K      K  +  + G          L ++ + + 
Sbjct: 482 --------------ANGILNVSAVDKSTGKENKITITNDKG---------RLSKEDIERM 518

Query: 720 VQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAS 779
           VQ+ +     D +++++  + NSLE++ F  +  +   + Q    +E +++I  K +   
Sbjct: 519 VQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEII 578

Query: 780 TWLEDEGVGATTVMLKEKLAELRKLCQGLFFRV 812
            WL D+   A     + +  EL K+C  +  ++
Sbjct: 579 NWL-DKNQTAEKEEFEHQQKELEKVCNPIITKL 610


>gi|24234686 heat shock 70kDa protein 8 isoform 2 [Homo sapiens]
          Length = 493

 Score =  222 bits (565), Expect = 2e-57
 Identities = 146/456 (32%), Positives = 239/456 (52%), Gaps = 33/456 (7%)

Query: 36  MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKA 95
           + +DLG+    V + + G  +EI+ N +  R TP  V   + ER  GD+A +    NP  
Sbjct: 7   VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65

Query: 96  TLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQ-FSPEEVLGMVL 154
           T+   + L+G++ D+  V      +P   +  D  R  V  +   + + F PEEV  MVL
Sbjct: 66  TVFDAKRLIGRRFDDAVVQSDMKHWP-FMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVL 124

Query: 155 NYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYG 214
              + +AE +  + + +AV+TVP +FN ++R+A   A  +AGL VL++IN+ TA A++YG
Sbjct: 125 TKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYG 184

Query: 215 VFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLE 274
           + ++       +N++ +D+G G+   +I+T       E G+    +++    D  LGG +
Sbjct: 185 LDKKVGAE---RNVLIFDLGGGTFDVSILTI------EDGI---FEVKSTAGDTHLGGED 232

Query: 275 MELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLM 334
            + R+       F  + K    KD+ EN RA+ +L     R K  LS++     +I+ L 
Sbjct: 233 FDNRMVNHFIAEFKRKHK----KDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLY 288

Query: 335 DDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQE 394
           + +DF   +TR  FEEL ADLF     PV++AL+ A++   +I  ++LVGG+TR+P++Q+
Sbjct: 289 EGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQK 348

Query: 395 VLLKAVGKEELGKNINADEAAAMGAVYQAAALS--KAFKVKPFVVRDAVVYPILVEFTRE 452
           +L      +EL K+IN DEA A GA  QAA LS  K+  V+  ++ D  V P+ +     
Sbjct: 349 LLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLD--VTPLSL----- 401

Query: 453 VEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYS 488
                GI +      VL  R    P ++  TF  YS
Sbjct: 402 -----GIETAGGVMTVLIKRNTTIPTKQTQTFTTYS 432


>gi|167466173 heat shock 70kDa protein 1B [Homo sapiens]
          Length = 641

 Score =  222 bits (565), Expect = 2e-57
 Identities = 155/526 (29%), Positives = 265/526 (50%), Gaps = 48/526 (9%)

Query: 34  AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNP 93
           A + +DLG+    V + + G  +EI+ N +  R TP  V   + ER  GD+A +    NP
Sbjct: 5   AAIGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNP 63

Query: 94  KATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQ-FSPEEVLGM 152
           + T+   + L+G++  +P V      +P  ++  D  +  V      + + F PEE+  M
Sbjct: 64  QNTVFDAKRLIGRKFGDPVVQSDMKHWP-FQVINDGDKPKVQVSYKGETKAFYPEEISSM 122

Query: 153 VLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALS 212
           VL   + +AE +   P+ +AVITVP +FN ++R+A   A  +AGL VL++IN+ TA A++
Sbjct: 123 VLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIA 182

Query: 213 YGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGG 272
           YG+ R        +N++ +D+G G+   +I+T       + G+    +++    D  LGG
Sbjct: 183 YGLDRT---GKGERNVLIFDLGGGTFDVSILTI------DDGI---FEVKATAGDTHLGG 230

Query: 273 LEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEG 332
            + +     RL   F E+ K +  KD+ +N RA+ +L     R K  LS++     +I+ 
Sbjct: 231 EDFD----NRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDS 286

Query: 333 LMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRV 392
           L + +DF   +TR  FEELC+DLF     PV++AL+ A++   +I  ++LVGG+TR+P+V
Sbjct: 287 LFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKV 346

Query: 393 QEVLLKAVGKEELGKNINADEAAAMGAVYQAAAL--SKAFKVKPFVVRDAVVYPILVEFT 450
           Q++L       +L K+IN DEA A GA  QAA L   K+  V+  ++ D  V P+ +   
Sbjct: 347 QKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLD--VAPLSL--- 401

Query: 451 REVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHD---FNFHINYGDLGFLGPED 507
                  G+ +       L  R    P ++   F  YS +       +  G+       +
Sbjct: 402 -------GLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNN 454

Query: 508 LRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSL 553
           L       L   +L G+  + +  P      I+  F++D +G+L++
Sbjct: 455 L-------LGRFELSGIPPAPRGVPQ-----IEVTFDIDANGILNV 488



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 51/266 (19%), Positives = 102/266 (38%), Gaps = 45/266 (16%)

Query: 547 ESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEE 606
           ++ +L  D+ E+V + L+ D A     L   G  +++L    +T   K+    T      
Sbjct: 376 QAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTY---- 431

Query: 607 SPAEGSKDEPGEQVELKEEAEAPVEDGS-------QPPPPEPKGDATPEGEKATEKENGD 659
                S ++PG  +++ E   A  +D +          PP P+G   P+ E   + +   
Sbjct: 432 -----SDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRG--VPQIEVTFDID--- 481

Query: 660 KSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQS 719
                           G+      +K    A K  +  + G          L ++++ + 
Sbjct: 482 --------------ANGILNVTATDKSTGKANKITITNDKG---------RLSKEEIERM 518

Query: 720 VQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAS 779
           VQ+ +     D  ++ER  A N+LE++ F  +  +     +   +E  ++++  K     
Sbjct: 519 VQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVI 578

Query: 780 TWLEDEGVGATTVMLKEKLAELRKLC 805
           +WL D    A     + K  EL ++C
Sbjct: 579 SWL-DANTLAEKDEFEHKRKELEQVC 603


>gi|194248072 heat shock 70kDa protein 1A [Homo sapiens]
          Length = 641

 Score =  222 bits (565), Expect = 2e-57
 Identities = 155/526 (29%), Positives = 265/526 (50%), Gaps = 48/526 (9%)

Query: 34  AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNP 93
           A + +DLG+    V + + G  +EI+ N +  R TP  V   + ER  GD+A +    NP
Sbjct: 5   AAIGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNP 63

Query: 94  KATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQ-FSPEEVLGM 152
           + T+   + L+G++  +P V      +P  ++  D  +  V      + + F PEE+  M
Sbjct: 64  QNTVFDAKRLIGRKFGDPVVQSDMKHWP-FQVINDGDKPKVQVSYKGETKAFYPEEISSM 122

Query: 153 VLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALS 212
           VL   + +AE +   P+ +AVITVP +FN ++R+A   A  +AGL VL++IN+ TA A++
Sbjct: 123 VLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIA 182

Query: 213 YGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGG 272
           YG+ R        +N++ +D+G G+   +I+T       + G+    +++    D  LGG
Sbjct: 183 YGLDRT---GKGERNVLIFDLGGGTFDVSILTI------DDGI---FEVKATAGDTHLGG 230

Query: 273 LEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEG 332
            + +     RL   F E+ K +  KD+ +N RA+ +L     R K  LS++     +I+ 
Sbjct: 231 EDFD----NRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDS 286

Query: 333 LMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRV 392
           L + +DF   +TR  FEELC+DLF     PV++AL+ A++   +I  ++LVGG+TR+P+V
Sbjct: 287 LFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKV 346

Query: 393 QEVLLKAVGKEELGKNINADEAAAMGAVYQAAAL--SKAFKVKPFVVRDAVVYPILVEFT 450
           Q++L       +L K+IN DEA A GA  QAA L   K+  V+  ++ D  V P+ +   
Sbjct: 347 QKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLD--VAPLSL--- 401

Query: 451 REVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHD---FNFHINYGDLGFLGPED 507
                  G+ +       L  R    P ++   F  YS +       +  G+       +
Sbjct: 402 -------GLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNN 454

Query: 508 LRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSL 553
           L       L   +L G+  + +  P      I+  F++D +G+L++
Sbjct: 455 L-------LGRFELSGIPPAPRGVPQ-----IEVTFDIDANGILNV 488



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 51/266 (19%), Positives = 102/266 (38%), Gaps = 45/266 (16%)

Query: 547 ESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEE 606
           ++ +L  D+ E+V + L+ D A     L   G  +++L    +T   K+    T      
Sbjct: 376 QAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTY---- 431

Query: 607 SPAEGSKDEPGEQVELKEEAEAPVEDGS-------QPPPPEPKGDATPEGEKATEKENGD 659
                S ++PG  +++ E   A  +D +          PP P+G   P+ E   + +   
Sbjct: 432 -----SDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRG--VPQIEVTFDID--- 481

Query: 660 KSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQS 719
                           G+      +K    A K  +  + G          L ++++ + 
Sbjct: 482 --------------ANGILNVTATDKSTGKANKITITNDKG---------RLSKEEIERM 518

Query: 720 VQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAS 779
           VQ+ +     D  ++ER  A N+LE++ F  +  +     +   +E  ++++  K     
Sbjct: 519 VQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVI 578

Query: 780 TWLEDEGVGATTVMLKEKLAELRKLC 805
           +WL D    A     + K  EL ++C
Sbjct: 579 SWL-DANTLAEKDEFEHKRKELEQVC 603


>gi|124256496 heat shock 70kDa protein 1-like [Homo sapiens]
          Length = 641

 Score =  219 bits (559), Expect = 8e-57
 Identities = 143/455 (31%), Positives = 235/455 (51%), Gaps = 31/455 (6%)

Query: 36  MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKA 95
           + +DLG+    V + + G  +EI+ N +  R TP  V   + ER  GD+A +    NP+ 
Sbjct: 9   IGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQN 67

Query: 96  TLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLN 155
           T+   + L+G++ ++P V      +P   +    + + +         F PEE+  MVL 
Sbjct: 68  TVFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLT 127

Query: 156 YSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGV 215
             +  AE F   P+ +AVITVP +FN ++R+A   A  +AGL VL++IN+ TA A++YG+
Sbjct: 128 KLKETAEAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGL 187

Query: 216 FRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEM 275
            +        ++++ +D+G G+   +I+T       + G+    +++    D  LGG + 
Sbjct: 188 DKG---GQGERHVLIFDLGGGTFDVSILTI------DDGI---FEVKATAGDTHLGGEDF 235

Query: 276 ELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMD 335
           +     RL   F E+ K +  KD+ +N RA+ +L     R K  LS++     +I+ L +
Sbjct: 236 D----NRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYE 291

Query: 336 DVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEV 395
            +DF   +TR  FEELCADLF     PV++AL+ A+M   +I  ++LVGG+TR+P+VQ +
Sbjct: 292 GIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKAKIHDIVLVGGSTRIPKVQRL 351

Query: 396 LLKAVGKEELGKNINADEAAAMGAVYQAAAL--SKAFKVKPFVVRDAVVYPILVEFTREV 453
           L       +L K+IN DEA A GA  QAA L   K+ KV+  ++ D  V P+ +      
Sbjct: 352 LQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLD--VAPLSL------ 403

Query: 454 EEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYS 488
               G+ +       L  R    P ++   F  YS
Sbjct: 404 ----GLETAGGVMTALIKRNSTIPTKQTQIFTTYS 434


>gi|13676857 heat shock 70kDa protein 2 [Homo sapiens]
          Length = 639

 Score =  215 bits (547), Expect = 2e-55
 Identities = 159/546 (29%), Positives = 274/546 (50%), Gaps = 54/546 (9%)

Query: 36  MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKA 95
           + +DLG+    V + + G  +EI+ N +  R TP  V   + ER  GD+A +    NP  
Sbjct: 8   IGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 66

Query: 96  TLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQ-FSPEEVLGMVL 154
           T+   + L+G++ ++  V      +P   +  +  +  V  +   + + F PEE+  MVL
Sbjct: 67  TIFDAKRLIGRKFEDATVQSDMKHWP-FRVVSEGGKPKVQVEYKGETKTFFPEEISSMVL 125

Query: 155 NYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYG 214
              + +AE +    +  AVITVP +FN ++R+A   A  + GL VL++IN+ TA A++YG
Sbjct: 126 TKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYG 185

Query: 215 VFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLE 274
           +  +K      +N++ +D+G G+   +I+T       E G+    +++    D  LGG +
Sbjct: 186 L-DKKGCAGGEKNVLIFDLGGGTFDVSILTI------EDGI---FEVKSTAGDTHLGGED 235

Query: 275 MELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLM 334
            + R+   LA  F  + K    KD+  N RA+ +L     R K  LS++     +I+ L 
Sbjct: 236 FDNRMVSHLAEEFKRKHK----KDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLY 291

Query: 335 DDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQE 394
           + VDF   +TR  FEEL ADLF     PV++AL+ A++   +I++++LVGG+TR+P++Q+
Sbjct: 292 EGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQK 351

Query: 395 VLLKAVGKEELGKNINADEAAAMGAVYQAAAL--SKAFKVKPFVVRDAVVYPILVEFTRE 452
           +L      +EL K+IN DEA A GA  QAA L   K+  V+  ++ D  V P+ +     
Sbjct: 352 LLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLD--VTPLSL----- 404

Query: 453 VEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFN---FHINYGDLGFLGPEDLR 509
                GI +       L  R    P ++  TF  YS + +     +  G+      +D  
Sbjct: 405 -----GIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAM--TKDNN 457

Query: 510 VFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAE 569
           + G  +LT     G+  + +  P      I+  F++D +G+L++        T  + S  
Sbjct: 458 LLGKFDLT-----GIPPAPRGVPQ-----IEVTFDIDANGILNV--------TAADKSTG 499

Query: 570 EESTLT 575
           +E+ +T
Sbjct: 500 KENKIT 505



 Score = 34.3 bits (77), Expect = 0.60
 Identities = 50/266 (18%), Positives = 99/266 (37%), Gaps = 31/266 (11%)

Query: 547 ESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEE 606
           ++ +L  D+ E+V + L+ D       +   G  ++ L    TT   K+  T T   + +
Sbjct: 379 QAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQ 438

Query: 607 SPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKP 666
           S       E GE+   K+       D +  PP  P+G   P+ E   + +          
Sbjct: 439 SSVLVQVYE-GERAMTKDNNLLGKFDLTGIPPA-PRG--VPQIEVTFDID---------- 484

Query: 667 SEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDL 726
                    G+      +K      K  +  + G          L +D + + VQ+ +  
Sbjct: 485 -------ANGILNVTAADKSTGKENKITITNDKG---------RLSKDDIDRMVQEAERY 528

Query: 727 TLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEG 786
              D   ++R  A N+LE++ +  +  +   + +   +E+ + +I  K      WL D  
Sbjct: 529 KSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWL-DRN 587

Query: 787 VGATTVMLKEKLAELRKLCQGLFFRV 812
             A     + K  EL ++C  +  ++
Sbjct: 588 QMAEKDEYEHKQKELERVCNPIISKL 613


>gi|16507237 heat shock 70kDa protein 5 [Homo sapiens]
          Length = 654

 Score =  207 bits (526), Expect = 5e-53
 Identities = 128/400 (32%), Positives = 213/400 (53%), Gaps = 22/400 (5%)

Query: 31  DTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLK-ENERFFGDSAASMA 89
           D   V+ +DLG+    V + K G  +EI+ N +  R TP  V    E ER  GD+A +  
Sbjct: 26  DVGTVVGIDLGTTYSCVGVFKNG-RVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQL 84

Query: 90  IKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISS--QLQFSPE 147
             NP+ T+   + L+G+  ++P V     +F   ++     +  +   I       F+PE
Sbjct: 85  TSNPENTVFDAKRLIGRTWNDPSVQ-QDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPE 143

Query: 148 EVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNT 207
           E+  MVL   +  AE +  + +  AV+TVP +FN A+R+A   A  +AGL V+++IN+ T
Sbjct: 144 EISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPT 203

Query: 208 ATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFD 267
           A A++YG+ +R+      +NI+ +D+G G+   +++T               ++     D
Sbjct: 204 AAAIAYGLDKREG----EKNILVFDLGGGTFDVSLLTID---------NGVFEVVATNGD 250

Query: 268 RTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHM 327
             LGG + + R+ E    L+    K +  KDVR++ RA+ KL RE  + K  LS+     
Sbjct: 251 THLGGEDFDQRVMEHFIKLY----KKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQAR 306

Query: 328 AQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGAT 387
            +IE   +  DF   +TR +FEEL  DLF     PVQ+ L+ +++   +I++++LVGG+T
Sbjct: 307 IEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGST 366

Query: 388 RVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALS 427
           R+P++Q+++ +    +E  + IN DEA A GA  QA  LS
Sbjct: 367 RIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLS 406


>gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens]
          Length = 679

 Score =  168 bits (425), Expect = 3e-41
 Identities = 120/401 (29%), Positives = 202/401 (50%), Gaps = 32/401 (7%)

Query: 34  AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLK-ENERFFGDSAASMAIKN 92
           AV+ +DLG+ +  VA+++ G   +++ N E  R TP +V    + ER  G  A   A+ N
Sbjct: 54  AVVGIDLGTTNSCVAVME-GKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTN 112

Query: 93  PKATLRYFQHLLGKQADNPHVA--LYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVL 150
           P  T    + L+G++ D+P V   +    F     +        H ++     +SP ++ 
Sbjct: 113 PNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKL-----YSPSQIG 167

Query: 151 GMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATA 210
             VL   +  AE++     K+AVITVP +FN ++R+A   A +++GL VL++IN+ TA A
Sbjct: 168 AFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAA 227

Query: 211 LSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTL 270
           L+YG+ + +D     + I  YD+G G+   +I+  Q         +   +++    D  L
Sbjct: 228 LAYGLDKSED-----KVIAVYDLGGGTFDISILEIQ---------KGVFEVKSTNGDTFL 273

Query: 271 GGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQI 330
           GG + +  L   +   F    K +   D+ ++  A+ ++   A + K  LS++      +
Sbjct: 274 GGEDFDQALLRHIVKEF----KRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINL 329

Query: 331 EGLMDDVD----FKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGA 386
             L  D         K+TR +FE +  DL  R   P Q+A+Q AE+S  +I +VILVGG 
Sbjct: 330 PYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGM 389

Query: 387 TRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALS 427
           TR+P+VQ+ +    G+    K +N DEA A+GA  Q   L+
Sbjct: 390 TRMPKVQQTVQDLFGRAP-SKAVNPDEAVAIGAAIQGGVLA 429


>gi|82880658 heat shock 70kDa protein 14 isoform 1 [Homo sapiens]
          Length = 509

 Score =  154 bits (388), Expect = 5e-37
 Identities = 114/397 (28%), Positives = 188/397 (47%), Gaps = 22/397 (5%)

Query: 33  LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKN 92
           +A + V LG  S  VA+ K G    +V N    R TP +V   ENE   G +A    I+N
Sbjct: 1   MAAIGVHLGCTSACVAVYKDG-RAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRN 59

Query: 93  PKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISS--QLQF-SPEEV 149
              T+   + +LG+ + +P    Y A   E +     +   + ++I +  + +F +PE+V
Sbjct: 60  ISNTVMKVKQILGRSSSDPQAQKYIA---ESKCLVIEKNGKLRYEIDTGEETKFVNPEDV 116

Query: 150 LGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTAT 209
             ++ +  +  A         D VITVP  F + ++ A+ +AAR AG  VL+LI++ +A 
Sbjct: 117 ARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAA 176

Query: 210 ALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRT 269
            L+YG+   +D  T   NI+ + +G  S   +++         +G+    ++     D  
Sbjct: 177 LLAYGI--GQDSPTGKSNILVFKLGGTSLSLSVMEVN------SGIY---RVLSTNTDDN 225

Query: 270 LGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQ 329
           +GG      L + LA  F    K     DVR N RAM KL   A   K  LS        
Sbjct: 226 IGGAHFTETLAQYLASEFQRSFK----HDVRGNARAMMKLTNSAEVAKHSLSTLGSANCF 281

Query: 330 IEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRV 389
           ++ L +  DF   V+R  FE LC+ LF +    ++  L     + D+I +V+L GG++R+
Sbjct: 282 LDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRI 341

Query: 390 PRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAAL 426
           P++Q+++       EL  +I  DE   +GA  +A  L
Sbjct: 342 PKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGIL 378


>gi|48928056 heat shock protein 70kDa family member 13 precursor
           [Homo sapiens]
          Length = 471

 Score =  137 bits (345), Expect = 5e-32
 Identities = 118/452 (26%), Positives = 216/452 (47%), Gaps = 63/452 (13%)

Query: 17  ALVAVLLADLLALS----DTLAVMSVDLGSESMKVAIVKPGV-PMEIVLNKESRRKTPVI 71
           A++ +LLA  LA       T  V+ +DLG+    V +  PG   ++++ ++      P +
Sbjct: 11  AVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSM 70

Query: 72  VTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQR 131
           V+  +N+ + G  +  +A  NP+ T+   +  +GK      +     R+P   L    + 
Sbjct: 71  VSFTDNDVYVGYESVELADSNPQNTIYDAKRFIGKIFTAEELEAEIGRYPFKVLN---KN 127

Query: 132 QTVHFQISSQ--LQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVL 189
             V F ++S   +  SPE V   +L   + +AE +   P+ +AVI+VP  F+  +R + +
Sbjct: 128 GMVEFSVTSNETITVSPEYVGSRLLLKLKEMAEAYLGMPVANAVISVPAEFDLKQRNSTI 187

Query: 190 QAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVK 249
           +AA +AGLK+L++IN+ TA A++YG+ +         +++  D+G G+   +++      
Sbjct: 188 EAANLAGLKILRVINEPTAAAMAYGLHK-----ADVFHVLVIDLGGGTLDVSLL------ 236

Query: 250 TKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQR--KGQRAKDVRENPRA-- 305
            K+ GM      R +  +  LGG +   RL + L     +       R +++    +A  
Sbjct: 237 NKQGGM---FLTRAMSGNNKLGGQDFNQRLLQYLYKQIYQTYGFVPSRKEEIHRLRQAVE 293

Query: 306 MAKL---LREANRL----------------------KTVLSANADHMAQI---EGLMD-- 335
           M KL   L ++ +L                      K  LS+  DH        GL D  
Sbjct: 294 MVKLNLTLHQSAQLSVLLTVEEQDRKEPHSSDTELPKDKLSSADDHRVNSGFGRGLSDKK 353

Query: 336 ----DVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPR 391
                V F+ +++R  F+ L  DLF+++  P+QQ L+   +   EI++V+LVGG+TR+PR
Sbjct: 354 SGESQVLFETEISRKLFDTLNEDLFQKILVPIQQVLKEGHLEKTEIDEVVLVGGSTRIPR 413

Query: 392 VQEVLLKAVGKEELGKNINADEAAAMGAVYQA 423
           +++V+ +  GK+    +++ D A   G   QA
Sbjct: 414 IRQVIQEFFGKDP-NTSVDPDLAVVTGVAIQA 444


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 95/434 (21%), Positives = 165/434 (38%), Gaps = 60/434 (13%)

Query: 595 ENGTDTVQEEEESPAEGSKDEPG-----EQVELKEEAEAPVEDGSQPPP----PEPKGDA 645
           E      +EE +SPAE    E       E+ +   EA++PV++ ++ P     PE     
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 646 TPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVV 705
           T E  K+ EK    + E  K  EKA++  +  A +P  EK + P +      E       
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP--EKAKSPVKAEAKSPEKAKS--- 696

Query: 706 LDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTE 765
                 P  + A+S +K +     + +  E+ K+    EA   +T +K   P  +E  + 
Sbjct: 697 ------PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA---KTPEKAKSPVKEEAKSP 747

Query: 766 EQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSAL 825
           E+      K    +  L+ +   A T   +E  +   K  +     V+E  K PE+  A 
Sbjct: 748 EK-----AKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK--AK 800

Query: 826 DNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPAT---- 881
             L   +       + IP+ +++ + V+    E+   E    +    AE+ K PAT    
Sbjct: 801 SPLKEDAK---APEKEIPKKEEVKSPVKE---EEKPQEVKVKEPPKKAEEEKAPATPKTE 854

Query: 882 ---------------EKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRA 926
                           KP +  K   A     + +V+    +A+  K  P P+ +   + 
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKV 914

Query: 927 EPPLNASASDQGEKVIPPAGQTEDAEPISEPEKVETGSEPGDTEPLELGGPGAEPE---- 982
           E   +A   ++ E         +  EP    EK E   E  DT+  +   P  +P+    
Sbjct: 915 EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK 974

Query: 983 -QKEQSTGQKRPLK 995
            +++  T  K P K
Sbjct: 975 AKEDDKTLSKEPSK 988



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 96/423 (22%), Positives = 160/423 (37%), Gaps = 47/423 (11%)

Query: 598 TDTVQEEEESPA---EGSKDEPGEQVELK---EEAEAPVEDGSQPPPPEPKGDATPEGEK 651
           T+ V EEEE  A   EG ++E GE+ E +   EE ++P  + +  P  E K     E + 
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS 526

Query: 652 ATEKENGDKSEAQKPSE-----------KAEAGPEGVAPAPEGEKKQKPA------RKRR 694
             E ++ +K EA+ P+E           K EA     A +PE E+ + PA      + + 
Sbjct: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS 586

Query: 695 MVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKL 754
             +E          P+  +  + +  +   +      E+ +      S E     T+++ 
Sbjct: 587 PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEA 646

Query: 755 YQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEE 814
             PE  +   +E+ +      S      +      + V  + K  E  K        V+E
Sbjct: 647 KSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK------SPVKE 700

Query: 815 RKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAE 874
             K PE+  +           +K     PE  +   + E  T EK   ++   + A   E
Sbjct: 701 EAKSPEKAKSP----------VKEEAKSPEKAKSPVKEEAKTPEKA--KSPVKEEAKSPE 748

Query: 875 QAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASA 934
           +AK P   K  L  K  EAK  A +          +  K   + + K+  +A+ PL   A
Sbjct: 749 KAKSPEKAK-TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA 807

Query: 935 SDQGEKVIPPAGQTEDAEPISEPEKVE--TGSEPGDTEPLELGGPGAEPEQKEQSTGQKR 992
               EK IP   + E   P+ E EK +     EP      E      + E+K+ S  ++ 
Sbjct: 808 K-APEKEIPK--KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA 864

Query: 993 PLK 995
           P K
Sbjct: 865 PKK 867



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 85/407 (20%), Positives = 152/407 (37%), Gaps = 49/407 (12%)

Query: 592 DAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEK 651
           +  E  T  V+E+ E      + +  E+V  +EE EA  E+G +            EG +
Sbjct: 448 EKSEKETVIVEEQTE------ETQVTEEVTEEEEKEAKEEEGKEE-----------EGGE 490

Query: 652 ATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDL 711
             E E G++     P+E+A A PE  A +P  E+ + PA  +   +E       +  P+ 
Sbjct: 491 EEEAEGGEEETKSPPAEEA-ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPE- 548

Query: 712 PEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEI 771
                A+S  K +  +  + +  E+E+A +  E    ++ +K   P  +E  +  + +  
Sbjct: 549 ----KAKSPAKEEAKSPPEAKSPEKEEAKSPAEV---KSPEKAKSPAKEEAKSPAEAKSP 601

Query: 772 SGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNH 831
               S      +      + V  + K     K  +      +E  K PE+  + +     
Sbjct: 602 EKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE----- 656

Query: 832 SSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDI 891
                K     PE  +   + E  + EK  +   A   A   E+AK P  E+    +K  
Sbjct: 657 -----KEEAKSPEKAKSPVKAEAKSPEKAKSPVKA--EAKSPEKAKSPVKEE----AKSP 705

Query: 892 EAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDA 951
           E     +  E +      +  K   + + K   +A+ P+   A    +   P   +T D 
Sbjct: 706 EKAKSPVKEEAK----SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761

Query: 952 E-PISEPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKND 997
           + P ++    E    P D  P +   P  E  +  +    K PLK D
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA--KSPLKED 806



 Score = 38.9 bits (89), Expect = 0.024
 Identities = 37/152 (24%), Positives = 62/152 (40%), Gaps = 25/152 (16%)

Query: 594  KENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKAT 653
            KE+  +  +EE E                 ++ + P  +   P   E K DA P+ +   
Sbjct: 886  KESKVEAKKEEAE-----------------DKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928

Query: 654  EKENGDKSEAQ---KPSEKAEAGPEGVAPAPEGEKK--QKPARKRRMVEEIGVELVVLDL 708
             K+  D ++A+   KP+EK EA PE      E  KK  +KP  + +  E+   +  +   
Sbjct: 929  AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED---DKTLSKE 985

Query: 709  PDLPEDKLAQSVQKLQDLTLRDLEKQEREKAA 740
            P  P+ + A+          +  EK   +KAA
Sbjct: 986  PSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 45/188 (23%), Positives = 69/188 (36%), Gaps = 14/188 (7%)

Query: 594 KENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQ------PPPPEPKGDATP 647
           KE     V+EEE+      K+ P +  E K  A    E+         P    PK     
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876

Query: 648 EGEKATEKENGDKSEAQK---PSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELV 704
           + E A EK    K EA+K     +K    PE  APA    K+    +++  V +   +  
Sbjct: 877 KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA 936

Query: 705 VLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVST 764
               P  P +K   + +K    T  +  K+  EK     +A   +  DK    E  +   
Sbjct: 937 KAKEPSKPAEKKEAAPEKKD--TKEEKAKKPEEKPKTEAKA---KEDDKTLSKEPSKPKA 991

Query: 765 EEQREEIS 772
           E+  +  S
Sbjct: 992 EKAEKSSS 999



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 25/101 (24%), Positives = 49/101 (48%), Gaps = 2/101 (1%)

Query: 592  DAKENGTDTVQEEEESPAEGSK-DEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGE 650
            DAK      V ++E   A+  +  +P E+ E   E +   E+ ++ P  +PK +A  + +
Sbjct: 919  DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978

Query: 651  KATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPAR 691
              T  +   K +A+K +EK+ +  +  +  PE   + K A+
Sbjct: 979  DKTLSKEPSKPKAEK-AEKSSSTDQKDSKPPEKATEDKAAK 1018



 Score = 34.3 bits (77), Expect = 0.60
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 13/90 (14%)

Query: 590  TPDAKENGTDTVQEEEESPAE---------GSKDEPGEQVELKEEAEAPVEDGSQPPPPE 640
            T  AK+   D   +E   PAE          +K+E  ++ E K + EA  ++  +    E
Sbjct: 926  TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985

Query: 641  PKGDATPEGEKATEKENGDKSEAQKPSEKA 670
            P   + P+ EKA +  + D+ ++ KP EKA
Sbjct: 986  P---SKPKAEKAEKSSSTDQKDS-KPPEKA 1011


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 114/479 (23%), Positives = 167/479 (34%), Gaps = 80/479 (16%)

Query: 512  GSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEE 571
            GSQ L   K   +G++       E +G K H N + S    L   E   E + E      
Sbjct: 1748 GSQRLNRDKDPKLGEAEGDAMAQEREG-KTH-NSETSAGSELGEAEQEGEGISERGETGG 1805

Query: 572  STLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVE 631
                   N       GG     + +G + ++  E   AEG      E VE  E AE   +
Sbjct: 1806 QGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPE---AEGEAQPESEGVEAPE-AEGDAQ 1861

Query: 632  DGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGV-APAPEGEKKQKPA 690
            +      PE +    PE E   + E+ D    + P  + E  PE   A APE EK+ +P 
Sbjct: 1862 EAEGEAQPESEDVEAPEAEGEAQPESED---VETPEAEWEVQPESEGAEAPEAEKEAQP- 1917

Query: 691  RKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFET 750
                  E   VE +  +  D PE + A              E QE E+AA   E      
Sbjct: 1918 ------ETESVEALETEGEDEPESEGA--------------EAQEAEEAAQEAEG----- 1952

Query: 751  QDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFF 810
                 QPE + + ++E  EE            E E V A  V ++ + AE      G   
Sbjct: 1953 ---QTQPESEVIESQEAEEEAQP---------ESEDVEALEVEVETQEAE------GEAQ 1994

Query: 811  RVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNA 870
               E  + PE    +      +     G    P+        E    ++V  ET   +  
Sbjct: 1995 PESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKS-------EGEEAQEVEGETQKTEGD 2047

Query: 871  TLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPL 930
               E   + A E         E +    + EVQ    +A      P  +D +   AE   
Sbjct: 2048 AQPESDGVEAPE--------AEEEAQEAEGEVQEAEGEA-----HPESEDVDAQEAEG-- 2092

Query: 931  NASASDQGEKVIPPAGQTEDAEPISEPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTG 989
             A    +G +     G+ + AE I  PE    G    ++E +E   P AE E + +S G
Sbjct: 2093 EAQPESEGVEAPEAEGEAQKAEGIEAPE--TEGEAQPESEGIE--APEAEGEAQPESEG 2147



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 40/189 (21%), Positives = 75/189 (39%), Gaps = 18/189 (9%)

Query: 591  PDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGE 650
            P+A E      +EE +  ++G + +P  + E  +E E   +       PE  G   PE E
Sbjct: 2003 PEA-EGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061

Query: 651  KATEKENGD----KSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVL 706
            +  ++  G+    + EA   SE  +A        PE E  + P  +    +  G+E    
Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPET 2121

Query: 707  DLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEE 766
            +    PE +  ++ +           + E +  +  +EA   +  +   QPE + +  +E
Sbjct: 2122 EGEAQPESEGIEAPE----------AEGEAQPESEGVEA---QDAEGEAQPESEGIEAQE 2168

Query: 767  QREEISGKL 775
              EE   +L
Sbjct: 2169 AEEEAQPEL 2177



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 8/110 (7%)

Query: 587  GGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDAT 646
            G   P+A+       +  E   AEG      E +E +E  E    +      PE +G+A 
Sbjct: 2131 GIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQ 2190

Query: 647  PEGE--KATEKENG-----DKSEAQKPSEKAEAGPEGVAPAPEGEKKQKP 689
            PE E  +A E E       +  EA +  E+A+  PEGV   PE E + +P
Sbjct: 2191 PESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV-ETPEAEGEAQP 2239



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 31/115 (26%), Positives = 46/115 (40%), Gaps = 16/115 (13%)

Query: 592  DAKENGTDTVQEEEESPAEGSKDEPGEQVELKEE----------AEAP-VEDGSQPPP-- 638
            +A+E     ++  E   AEG      E +E  E            EAP  E+ +QP P  
Sbjct: 2168 EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEG 2227

Query: 639  ---PEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPA 690
               PE +G+A PE E  T+ E     +      ++E   E  +P PE      P+
Sbjct: 2228 VETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPS 2282



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 32/117 (27%), Positives = 53/117 (45%), Gaps = 15/117 (12%)

Query: 587  GGTTPDAKENGTDTVQEEEESPAEGSKDEPGE-QVELKEEAEAPVEDGSQPPP------P 639
            G   P++++      + E +  +EG +    E + +  E  EAP  +G   P       P
Sbjct: 2076 GEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAP 2135

Query: 640  EPKGDATPEGE-------KATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKP 689
            E +G+A PE E       +   +   +  EAQ+  E+A+   EGV  APE E + +P
Sbjct: 2136 EAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGV-EAPEAEGEAQP 2191



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 56/209 (26%), Positives = 93/209 (44%), Gaps = 28/209 (13%)

Query: 557  ESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEES--------- 607
            E++ E L E+   EE ++   G  +S      ++PD K +  D   +EEE+         
Sbjct: 1388 EALEEGLKEEGLPEEGSVH--GQELSE----ASSPDGKGSQEDDPVQEEEAGRASASAEP 1441

Query: 608  -PAEGSKD--EPGEQVELKEEAEAPVEDGSQPPP--PEPKGDATPEGEKATEKE----NG 658
             PAEG+++  EP   +   + + +  + GSQ  P   +P G AT  G++ T+ +      
Sbjct: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPG-ATMMGQEHTQAQPTQGAA 1500

Query: 659  DKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVE--LVVLDLPDLPEDKL 716
            ++S +   S   +  P  V+   +  +K   A     V E+     L   DL D    +L
Sbjct: 1501 ERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAEL 1560

Query: 717  AQSV-QKLQDLTLRDLEKQEREKAANSLE 744
             Q V Q+LQD T R+L+K +       LE
Sbjct: 1561 QQDVAQRLQDSTKRELQKLQGRAGRMVLE 1589



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 27/82 (32%), Positives = 37/82 (45%), Gaps = 6/82 (7%)

Query: 611  GSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKA 670
            G + +PG+   L+   E P + G Q    +P  D  PEG      + G +S    P    
Sbjct: 989  GPEVDPGDDHSLEGLGE-PAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQ--- 1044

Query: 671  EAGPEGV--APAPEGEKKQKPA 690
             A PEGV  APA  G  ++ PA
Sbjct: 1045 GAAPEGVSEAPAEAGADREAPA 1066



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 44/199 (22%), Positives = 81/199 (40%), Gaps = 19/199 (9%)

Query: 587  GGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDAT 646
            G   P+++       + E +  +EG + +  E     E      ++  +   PE +G   
Sbjct: 2123 GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182

Query: 647  PEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVL 706
            PE E   + E+ +  EA +   +A+   EGV  APE E++ +P       E  GVE    
Sbjct: 2183 PEAEGEAQPES-EGIEAPEAEGEAQPELEGV-EAPEAEEEAQP-------EPEGVETPEA 2233

Query: 707  DLPDLPEDKLAQSVQK--LQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVST 764
            +    PE +     +K     ++L D + +E  ++++ +       +D+   P      T
Sbjct: 2234 EGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPV------PEDRPTPPPSPGGDT 2287

Query: 765  EEQR--EEISGKLSAASTW 781
              QR   +     S AS+W
Sbjct: 2288 PHQRPGSQTGPSSSRASSW 2306



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 35/131 (26%), Positives = 51/131 (38%), Gaps = 25/131 (19%)

Query: 535  ESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEEST---LTKLGNTISSLFGGGTTP 591
            ES+GI+A    +E     L+ VE+      E  A+ ES      +          G   P
Sbjct: 2160 ESEGIEAQ-EAEEEAQPELEGVEA---PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAP 2215

Query: 592  DAKEN------GTDTVQEEEESPAEGSKDEPGE------------QVELKEEAEAPVEDG 633
            +A+E       G +T + E E+  E   +  GE            Q E   E+ +PV + 
Sbjct: 2216 EAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275

Query: 634  SQPPPPEPKGD 644
               PPP P GD
Sbjct: 2276 RPTPPPSPGGD 2286



 Score = 31.2 bits (69), Expect = 5.1
 Identities = 42/152 (27%), Positives = 59/152 (38%), Gaps = 32/152 (21%)

Query: 540  KAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNT--------------ISSLF 585
            K    L E GV    ++E   ET  E   EEE+ L ++  T              +    
Sbjct: 1326 KTEEGLQEEGV----QLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP 1381

Query: 586  GGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPP---EPK 642
             GG   +A E G     +EE  P EGS    G+++    EA +P   GSQ   P   E  
Sbjct: 1382 EGGLQGEALEEGL----KEEGLPEEGSVH--GQELS---EASSPDGKGSQEDDPVQEEEA 1432

Query: 643  GDATPEGEKATEKENGDKSEAQKPSEKAEAGP 674
            G A+   E    +  G +   + PS  +E  P
Sbjct: 1433 GRASASAEPCPAE--GTEEPTEPPSHLSETDP 1462


>gi|70980549 programmed cell death 11 [Homo sapiens]
          Length = 1871

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 67/290 (23%), Positives = 114/290 (39%), Gaps = 46/290 (15%)

Query: 581  ISSLFGGGTTPD---AKENGTDTVQEEEESPAEGSKDEPGEQVELK----------EEAE 627
            +S L G    PD   A   G  T QEE ++ AE  +D+ GE+   K          EE E
Sbjct: 1393 LSFLPGDTGKPDVLSASLEGQLTKQEERKTEAE-ERDQKGEKKNQKRNEKKNQKGQEEVE 1451

Query: 628  APVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGP-----------EG 676
             P ++  QP  P+    A   G +   +   ++    K  +KA               EG
Sbjct: 1452 MPSKEKQQPQKPQ----AQKRGGRECRESGSEQERVSKKPKKAGLSEEDDSLVDVYYREG 1507

Query: 677  VAPAPE-----GEKKQKPARKRRM------VEEIGVELVVLDLPDLPEDKLAQSVQKLQD 725
               A E      EK+ KPA   R+         +G++ +   LP L E   ++  +K   
Sbjct: 1508 KEEAEETNVLPKEKQTKPAEAPRLQLSSGFAWNVGLDSLTPALPPLAESSDSEEDEKPHQ 1567

Query: 726  LTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDE 785
             T++   K+ERE      E  +   ++ L  P  Q  S ++    +    +++  WL+  
Sbjct: 1568 ATIKK-SKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDRLVLSSPNSSILWLQYM 1626

Query: 786  GVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMF 835
                    +++  A   +  + + FR E+     E+L+    LLN  +M+
Sbjct: 1627 AFHLQATEIEKARAVAERALKTISFREEQ-----EKLNVWVALLNLENMY 1671


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 102/441 (23%), Positives = 173/441 (39%), Gaps = 63/441 (14%)

Query: 557 ESVFETLVEDSAEE-ESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDE 615
           E + ET VED   E E  LT +   ++          A+E   +   EEEE  A+ S  +
Sbjct: 455 EIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK 514

Query: 616 PGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPE 675
                  +EE E   E+G +    E       EG K+ + E G  SE +  SEK E   E
Sbjct: 515 ATAPEVKEEEGEKEEEEGQEEEEEE------DEGAKSDQAEEGG-SEKEGSSEKEEGEQE 567

Query: 676 GVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQE 735
                 E E ++  A++ + VEE   E+                    ++  + D + ++
Sbjct: 568 EGETEAEAEGEEAEAKEEKKVEEKSEEVAT------------------KEELVADAKVEK 609

Query: 736 REKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEG---VGATTV 792
            EKA + +     E + K   P+    S  E++    GK     + +E++G   V  + V
Sbjct: 610 PEKAKSPVPKSPVEEKGKSPVPK----SPVEEK----GKSPVPKSPVEEKGKSPVPKSPV 661

Query: 793 MLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEV 852
             K K    +         VEE+ K P   S ++   + + +  KG +   E  ++    
Sbjct: 662 EEKGKSPVSKS-------PVEEKAKSPVPKSPVEEAKSKAEVG-KGEQKEEEEKEV---K 710

Query: 853 EMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNK--AK 910
           E    EKV  +    K+    ++A+ P  E+ V       A+++ + + V+  L K   +
Sbjct: 711 EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV-------AEVVTITKSVKVHLEKETKE 763

Query: 911 FTKPRPRPKDKNGTRAEPPLNASASDQGEK-----VIPPAGQTEDAEPISEPEKVETGSE 965
             KP  + K+K     E       SD+G K      I   G+ E  E + E E  E GS 
Sbjct: 764 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEV-EQETKEKGSG 822

Query: 966 PGDTEPLELGGPGAEPEQKEQ 986
             + + +   G    P  +++
Sbjct: 823 REEEKGVVTNGLDLSPADEKK 843



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 76/312 (24%), Positives = 130/312 (41%), Gaps = 51/312 (16%)

Query: 530 KYPDYESKGIKAHFNLDESGVLSL--DRVESVFETLVEDSAEEESTLTKLGNTISSLFGG 587
           K  D +S+  +A   + E   +S+  ++ E+  E   E  AEEE    K     +     
Sbjct: 461 KVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKA----- 515

Query: 588 GTTPDAKEN--------GTDTVQEEEE-----------SPAEGSKD-EPGEQVELKEEAE 627
            T P+ KE         G +  +EE+E           S  EGS + E GEQ E + EAE
Sbjct: 516 -TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 574

Query: 628 APVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSE------KAEAGPEGVAPAP 681
           A   +G +    E K       E AT++E    ++ +KP +      K+    +G +P P
Sbjct: 575 A---EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP 631

Query: 682 EG--EKKQKPARKRRMVEEIGVELVVLDLPDLP-EDKLAQSVQK--LQDLTLRDLEKQER 736
           +   E+K K    +  VEE G   V    P  P E+K    V K  +++     + K   
Sbjct: 632 KSPVEEKGKSPVPKSPVEEKGKSPV----PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 687

Query: 737 EKAANSLEAFIFETQDKLYQ-----PEYQEVSTEEQREEISGKLSAASTWLEDEGVGATT 791
           E+A +  E    E +++  +     P+ ++V  +E++ +   +   A + +++E V    
Sbjct: 688 EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV 747

Query: 792 VMLKEKLAELRK 803
            + K     L K
Sbjct: 748 TITKSVKVHLEK 759



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 58/288 (20%), Positives = 113/288 (39%), Gaps = 18/288 (6%)

Query: 713 EDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEIS 772
           ++++A+  ++LQ  ++ +LE     K +   +    E +       YQ+   + + E   
Sbjct: 314 KEEIAEYRRQLQSKSI-ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRG 372

Query: 773 GKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHS 832
            K   A    E + +    + L  ++A  RKL +G     EE +      S    L  H 
Sbjct: 373 TKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEG-----EETRFSTFAGSITGPLYTHR 427

Query: 833 SMFLKGARLI-PEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDI 891
                 +++  P+++    +V+   +E++I ET      +  E+A    TE+  +  K+ 
Sbjct: 428 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE- 486

Query: 892 EAKMMALDREVQ-------YLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPP 944
           E K  A ++E +           K+      P  K++ G + E        ++ E     
Sbjct: 487 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 546

Query: 945 AGQTEDAEPISEPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTGQKR 992
             +   +E     EK E   E G+T   E    G E E KE+   +++
Sbjct: 547 QAEEGGSEKEGSSEKEEGEQEEGET---EAEAEGEEAEAKEEKKVEEK 591


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 102/441 (23%), Positives = 173/441 (39%), Gaps = 63/441 (14%)

Query: 557 ESVFETLVEDSAEE-ESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDE 615
           E + ET VED   E E  LT +   ++          A+E   +   EEEE  A+ S  +
Sbjct: 79  EIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK 138

Query: 616 PGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPE 675
                  +EE E   E+G +    E       EG K+ + E G  SE +  SEK E   E
Sbjct: 139 ATAPEVKEEEGEKEEEEGQEEEEEE------DEGAKSDQAEEGG-SEKEGSSEKEEGEQE 191

Query: 676 GVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQE 735
                 E E ++  A++ + VEE   E+                    ++  + D + ++
Sbjct: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVAT------------------KEELVADAKVEK 233

Query: 736 REKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEG---VGATTV 792
            EKA + +     E + K   P+    S  E++    GK     + +E++G   V  + V
Sbjct: 234 PEKAKSPVPKSPVEEKGKSPVPK----SPVEEK----GKSPVPKSPVEEKGKSPVPKSPV 285

Query: 793 MLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEV 852
             K K    +         VEE+ K P   S ++   + + +  KG +   E  ++    
Sbjct: 286 EEKGKSPVSKS-------PVEEKAKSPVPKSPVEEAKSKAEVG-KGEQKEEEEKEV---K 334

Query: 853 EMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNK--AK 910
           E    EKV  +    K+    ++A+ P  E+ V       A+++ + + V+  L K   +
Sbjct: 335 EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV-------AEVVTITKSVKVHLEKETKE 387

Query: 911 FTKPRPRPKDKNGTRAEPPLNASASDQGEK-----VIPPAGQTEDAEPISEPEKVETGSE 965
             KP  + K+K     E       SD+G K      I   G+ E  E + E E  E GS 
Sbjct: 388 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEV-EQETKEKGSG 446

Query: 966 PGDTEPLELGGPGAEPEQKEQ 986
             + + +   G    P  +++
Sbjct: 447 REEEKGVVTNGLDLSPADEKK 467



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 76/312 (24%), Positives = 130/312 (41%), Gaps = 51/312 (16%)

Query: 530 KYPDYESKGIKAHFNLDESGVLSL--DRVESVFETLVEDSAEEESTLTKLGNTISSLFGG 587
           K  D +S+  +A   + E   +S+  ++ E+  E   E  AEEE    K     +     
Sbjct: 85  KVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKA----- 139

Query: 588 GTTPDAKEN--------GTDTVQEEEE-----------SPAEGSKD-EPGEQVELKEEAE 627
            T P+ KE         G +  +EE+E           S  EGS + E GEQ E + EAE
Sbjct: 140 -TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 198

Query: 628 APVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSE------KAEAGPEGVAPAP 681
           A   +G +    E K       E AT++E    ++ +KP +      K+    +G +P P
Sbjct: 199 A---EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP 255

Query: 682 EG--EKKQKPARKRRMVEEIGVELVVLDLPDLP-EDKLAQSVQK--LQDLTLRDLEKQER 736
           +   E+K K    +  VEE G   V    P  P E+K    V K  +++     + K   
Sbjct: 256 KSPVEEKGKSPVPKSPVEEKGKSPV----PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 311

Query: 737 EKAANSLEAFIFETQDKLYQ-----PEYQEVSTEEQREEISGKLSAASTWLEDEGVGATT 791
           E+A +  E    E +++  +     P+ ++V  +E++ +   +   A + +++E V    
Sbjct: 312 EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV 371

Query: 792 VMLKEKLAELRK 803
            + K     L K
Sbjct: 372 TITKSVKVHLEK 383



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 34/157 (21%), Positives = 63/157 (40%), Gaps = 11/157 (7%)

Query: 843 PEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREV 902
           P+++    +V+   +E++I ET      +  E+A    TE+  +  K+ E K  A ++E 
Sbjct: 63  PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE-EKKEAAEEKEE 121

Query: 903 Q-------YLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPIS 955
           +           K+      P  K++ G + E        ++ E       +   +E   
Sbjct: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEG 181

Query: 956 EPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTGQKR 992
             EK E   E G+T   E    G E E KE+   +++
Sbjct: 182 SSEKEEGEQEEGET---EAEAEGEEAEAKEEKKVEEK 215


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 144/667 (21%), Positives = 235/667 (35%), Gaps = 132/667 (19%)

Query: 401 GKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIH 460
           G+E   K++  D         +    +   + K   VR+A +   L E  ++VE  P I 
Sbjct: 65  GQEMTSKSLQTDTIVEEKKEVKLVEETVVPEEKSADVREAAIE--LPESVQDVEIPPNIP 122

Query: 461 S--LKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTT 518
           S  LK ++    SR G +    +    +   +   + +  ++  +   D     S+    
Sbjct: 123 SVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSKE-DA 181

Query: 519 VKLKGVGDSF-KKYPDYESKGIKAHFNLDESGVLSLDRVESVFET------LVEDSAEEE 571
           +K K  G  F  ++P+++     A  + +E G  ++ R     ET      L+ED   EE
Sbjct: 182 LKHKSSGKIFASEHPEFQP----ATNSNEEIGQKNISRTSFTQETKKGPPVLLEDELREE 237

Query: 572 STLTKL--GNTISSLFGGGTTPDAKENGTDTVQ---------EEEESPAEGSKDEPGEQV 620
            T+  +  G+ +  +      P + E     +Q         + E  PAE +  +     
Sbjct: 238 VTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPST 297

Query: 621 ELKEEAEAP--VEDGS---QPPPPE-------------PKGDATPEGEKATE--KENGDK 660
           E   +AEA   V + S   QPPP E             P  + +P  E   E    + ++
Sbjct: 298 EETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEE 357

Query: 661 SEAQKP----------------------SEKAEAGPEGVAPAP-EGEKKQKPARKRRMVE 697
           S +++P                      S  A+  P  V P P EG  ++ PA+    VE
Sbjct: 358 SPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAK----VE 413

Query: 698 EIGVELVVLDL-PDLPEDKLAQSVQKLQDLTLRDLEKQE----------REKAANSLEAF 746
              VE  + D+ P LPE+   +  ++LQ  T  +   +E          +E  A    A 
Sbjct: 414 PPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASAE 473

Query: 747 IF----------ETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE 796
           I           ET  +   P  +E S EE   E+   L A  T  E+       +   E
Sbjct: 474 IQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPL-AEETTAEEASAEIQLLAAIE 532

Query: 797 KLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGA-------RLIPEMDQIF 849
             A+            E +    E  SA +      S   KG         L P   +  
Sbjct: 533 APADETP--------AEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEET 584

Query: 850 TEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKA 909
           T  E +   +++  T A      AE    PA E P                EVQ    + 
Sbjct: 585 TAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPA---------------EVQPPPAEE 629

Query: 910 KFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAE---PISEPEKVETGSEP 966
              + +P P ++     +PP    A +   +V PP  +   AE   P +E    E  S P
Sbjct: 630 APAEVQPPPAEEAPAEVQPP---PAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLP 686

Query: 967 GDTEPLE 973
            +  P+E
Sbjct: 687 AEETPIE 693



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 33/151 (21%), Positives = 58/151 (38%), Gaps = 10/151 (6%)

Query: 843 PEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREV 902
           P +++   +V+    E+   E    +   L+   + PA E P      +  +  A +   
Sbjct: 415 PTVEETLADVQPLLPEEAPREEA--RELQLSTAMETPAEEAPTEFQSPLPKETTAEEASA 472

Query: 903 QYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQ---GEKVIPPAGQTEDAEPISEPEK 959
           +  L  A  T+P   P D+    A  PL+   S +    E   P A +T   E  +E + 
Sbjct: 473 EIQLLAA--TEP---PADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQL 527

Query: 960 VETGSEPGDTEPLELGGPGAEPEQKEQSTGQ 990
           +     P D  P E   P +E    E++  +
Sbjct: 528 LAAIEAPADETPAEAQSPLSEETSAEEAPAE 558


>gi|225543215 antigen identified by monoclonal antibody Ki-67
           isoform 2 [Homo sapiens]
          Length = 2896

 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 78/355 (21%), Positives = 131/355 (36%), Gaps = 47/355 (13%)

Query: 508 LRVFGSQNLTTVKLKGVGDSFKKY-PDYESKGIKAHFNLDESGVLSLDRVESVFETLVED 566
           + +  S+NL   + +G     +   P  ES G    F+   +     D+  S    L   
Sbjct: 415 IAISNSENLLGKQFQGTDSGEEPLLPTSESFGGNVFFSAQNAAKQPSDKC-SASPPLRRQ 473

Query: 567 SAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEA 626
              E   + K       +    T+ + K + T+T    E S    + +  G   E +   
Sbjct: 474 CIRENGNVAKTPRNTYKM----TSLETKTSDTET----EPSKTVSTANRSGRSTEFRNIQ 525

Query: 627 EAPVEDGSQPPPPEPKGDATPEGEKAT---EKENGDKSEAQKPSEKAEAGPEGVAPAPEG 683
           + PVE  S+    E        G+KAT   ++  G+  E ++P E  +   E +      
Sbjct: 526 KLPVESKSEETNTEIVECILKRGQKATLLQQRREGEMKEIERPFETYK---ENIELKEND 582

Query: 684 EKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSL 743
           EK +   R R   ++      + DL  LP+ +L +   + Q+L    L+ Q+  KA  S 
Sbjct: 583 EKMKAMKRSRTWGQKCAPMSDLTDLKSLPDTELMKDTARGQNL----LQTQDHAKAPKSE 638

Query: 744 EAFIFETQDKLYQPEYQEVSTEEQ------------REEI--SGKLSAAS-----TWLED 784
           +  I +   +  QPE     T  +            +EE+   GK +  S     T  E 
Sbjct: 639 KGKITKMPCQSLQPEPINTPTHTKQQLKASLGKVGVKEELLAVGKFTRTSGETTHTHREP 698

Query: 785 EGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWP----ERLSALDNLLNHSSMF 835
            G G +    KE   ++         RV   KKWP    E   +L++L     +F
Sbjct: 699 AGDGKSIRTFKESPKQILDPAA----RVTGMKKWPRTPKEEAQSLEDLAGFKELF 749


>gi|103472005 antigen identified by monoclonal antibody Ki-67 isoform
            1 [Homo sapiens]
          Length = 3256

 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 78/355 (21%), Positives = 131/355 (36%), Gaps = 47/355 (13%)

Query: 508  LRVFGSQNLTTVKLKGVGDSFKKY-PDYESKGIKAHFNLDESGVLSLDRVESVFETLVED 566
            + +  S+NL   + +G     +   P  ES G    F+   +     D+  S    L   
Sbjct: 775  IAISNSENLLGKQFQGTDSGEEPLLPTSESFGGNVFFSAQNAAKQPSDKC-SASPPLRRQ 833

Query: 567  SAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEA 626
               E   + K       +    T+ + K + T+T    E S    + +  G   E +   
Sbjct: 834  CIRENGNVAKTPRNTYKM----TSLETKTSDTET----EPSKTVSTANRSGRSTEFRNIQ 885

Query: 627  EAPVEDGSQPPPPEPKGDATPEGEKAT---EKENGDKSEAQKPSEKAEAGPEGVAPAPEG 683
            + PVE  S+    E        G+KAT   ++  G+  E ++P E  +   E +      
Sbjct: 886  KLPVESKSEETNTEIVECILKRGQKATLLQQRREGEMKEIERPFETYK---ENIELKEND 942

Query: 684  EKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSL 743
            EK +   R R   ++      + DL  LP+ +L +   + Q+L    L+ Q+  KA  S 
Sbjct: 943  EKMKAMKRSRTWGQKCAPMSDLTDLKSLPDTELMKDTARGQNL----LQTQDHAKAPKSE 998

Query: 744  EAFIFETQDKLYQPEYQEVSTEEQ------------REEI--SGKLSAAS-----TWLED 784
            +  I +   +  QPE     T  +            +EE+   GK +  S     T  E 
Sbjct: 999  KGKITKMPCQSLQPEPINTPTHTKQQLKASLGKVGVKEELLAVGKFTRTSGETTHTHREP 1058

Query: 785  EGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWP----ERLSALDNLLNHSSMF 835
             G G +    KE   ++         RV   KKWP    E   +L++L     +F
Sbjct: 1059 AGDGKSIRTFKESPKQILDPAA----RVTGMKKWPRTPKEEAQSLEDLAGFKELF 1109


>gi|24308394 hypothetical protein LOC140893 [Homo sapiens]
          Length = 664

 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 43/137 (31%), Positives = 54/137 (39%), Gaps = 26/137 (18%)

Query: 590 TPDAKENGTDTV----QEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQP-PPPEPKG- 643
           +P A  NGT       QEE  +P + S+  PG Q+ L        ED  +P PPP P+  
Sbjct: 487 SPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPP 546

Query: 644 --------DATPEGEKA--TEKENGDKSEAQKP------SEKAEAGPEGVAPAPE----G 683
                   D  PE  KA     E+ +  E   P      S +AEA        PE     
Sbjct: 547 PHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQ 606

Query: 684 EKKQKPARKRRMVEEIG 700
           E  Q P RKR+   E G
Sbjct: 607 EHGQGPPRKRKRASEPG 623


>gi|20270186 high mobility group nucleosomal binding domain 3
           isoform HMGN3a [Homo sapiens]
          Length = 99

 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 1/97 (1%)

Query: 604 EEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEA 663
           + +SP E ++ + G +V  +E         ++P PP+P+        K        +   
Sbjct: 3   KRKSP-ENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAK 61

Query: 664 QKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIG 700
            K  EK EAG EG AP+  GE K + A+K   V+  G
Sbjct: 62  GKKEEKQEAGKEGTAPSENGETKAEEAQKTESVDNEG 98


>gi|33286446 opioid growth factor receptor [Homo sapiens]
          Length = 677

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 34/134 (25%), Positives = 47/134 (35%), Gaps = 9/134 (6%)

Query: 566 DSAEEESTLTKLGNTISSLFGGGTTPDA------KENGTDTVQEEEESPAEGSKDEPGEQ 619
           D    +S     G   +    G   P         ENG +   E    P EG+   P E 
Sbjct: 462 DEGAGDSAAVASGGAQTLALAGSPAPSGHPKAGHSENGVEEDTEGRTGPKEGTPGSPSET 521

Query: 620 VELKEEAEA---PVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEG 676
                   A   P E  S+ P P P G A  E  ++  +  G +       E AE+  E 
Sbjct: 522 PGPSPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSET 581

Query: 677 VAPAPEGEKKQKPA 690
             P+P G  + +PA
Sbjct: 582 PGPSPAGPTRDEPA 595



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 26/92 (28%), Positives = 38/92 (41%), Gaps = 1/92 (1%)

Query: 606 ESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQK 665
           + PAE   + PG         E P E  S+ P P P G A  E  ++  +  G +     
Sbjct: 572 DEPAESPSETPGPSPAGPTRDE-PAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPA 630

Query: 666 PSEKAEAGPEGVAPAPEGEKKQKPARKRRMVE 697
             E AE+  E   P+P G  + +PA+     E
Sbjct: 631 GDEPAESPSETPGPSPAGPTRDEPAKAGEAAE 662



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 24/85 (28%), Positives = 34/85 (40%), Gaps = 1/85 (1%)

Query: 606 ESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQK 665
           + PAE   + PG +       + P E  S+ P P P G A  E  ++  +  G       
Sbjct: 532 DEPAESPSETPGPR-PAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPSPAGPT 590

Query: 666 PSEKAEAGPEGVAPAPEGEKKQKPA 690
             E AE+  E   P P G    +PA
Sbjct: 591 RDEPAESPSETPGPRPAGPAGDEPA 615



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 22/86 (25%), Positives = 32/86 (37%), Gaps = 1/86 (1%)

Query: 606 ESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQK 665
           + PAE   + PG +       + P E  S+ P P P G A  E  ++  +  G       
Sbjct: 592 DEPAESPSETPGPR-PAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPSPAGPT 650

Query: 666 PSEKAEAGPEGVAPAPEGEKKQKPAR 691
             E A+AG        E E   K  +
Sbjct: 651 RDEPAKAGEAAELQDAEVESSAKSGK 676


>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
          Length = 674

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 49/213 (23%), Positives = 83/213 (38%), Gaps = 8/213 (3%)

Query: 556 VESVFETLVEDSAEEESTLTKLGNTISS----LFGGGTTPDAKENGTDTVQEEE--ESPA 609
           +ES  ET  +     E+     G T+      L    T P   E       EE   E P 
Sbjct: 151 LESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPE 210

Query: 610 EGSKDEPGEQV-ELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSE 668
           +  +D P E++ E  EE +      ++P  PE     + E +K TE     + E  +   
Sbjct: 211 QTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTE-KKRTEPPEQARLEFLEKEP 269

Query: 669 KAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTL 728
           +  +   G+ P  E + +     +R+  EE G EL     PD P+ K  +S  +     L
Sbjct: 270 RKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPL 329

Query: 729 RDLEKQEREKAANSLEAFIFETQDKLYQPEYQE 761
            +++ +  E+ +          Q ++ +PE  E
Sbjct: 330 EEIKLEFPEEESRKTNEETILEQSEMMKPESPE 362



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 54/226 (23%), Positives = 84/226 (37%), Gaps = 28/226 (12%)

Query: 591 PDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGE 650
           PD K     +  E    P E  K E  E+   K   E  +E      P  P+     E  
Sbjct: 313 PDHKPR--KSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPE-----EIR 365

Query: 651 KATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARK------RRMVEEIGVELV 704
           K+ EK+N      Q P E     P+ + P  E + + KP  K           E  VE  
Sbjct: 366 KSNEKKN-----PQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFS 420

Query: 705 VLDLPD-------LPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEA-FIFETQDKLYQ 756
             D P+       +  D+L     K   L+L D  ++E     +  E+     T  +  Q
Sbjct: 421 KEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQ 480

Query: 757 P--EYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAE 800
           P  +   VS E    + S   +  S ++ ++ V   +  LKE+++E
Sbjct: 481 PLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSE 526


>gi|186700623 Rab-like GTP-binding protein 1 isoform 1 [Homo
           sapiens]
          Length = 729

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 44/169 (26%), Positives = 69/169 (40%), Gaps = 42/169 (24%)

Query: 591 PDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGE 650
           PD +  G+DT +  ++ P    +D+P +   + +E E P E     PPP PK        
Sbjct: 573 PDFESEGSDTQRRADDFPV---RDDPSD---VTDEDEGPAE-----PPPPPKLPLPAFRL 621

Query: 651 KATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPD 710
           K      G   E   P E +E G EG  P+ E +KK+K  ++                  
Sbjct: 622 KNDSDLFGLGLEEAGPKESSEEGKEGKTPSKEKKKKKKKGKEE----------------- 664

Query: 711 LPEDKLAQSVQKLQDLTLRDLEKQEREK------------AANSLEAFI 747
             E+K A+   K +    ++  K+ER +            AA+ LEAF+
Sbjct: 665 --EEKAAKKKSKHKKSKDKEEGKEERRRRQQRPPRSRERTAADELEAFL 711


>gi|14141161 heterogeneous nuclear ribonucleoprotein U isoform b
           [Homo sapiens]
          Length = 806

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 55/193 (28%), Positives = 80/193 (41%), Gaps = 26/193 (13%)

Query: 515 NLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTL 574
           N+  +K+  + +  KK      KG+KA   L E    +LD  E+     +E      +  
Sbjct: 7   NVKKLKVSELKEELKKRR-LSDKGLKAE--LMERLQAALDDEEAGGRPAMEPG----NGS 59

Query: 575 TKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGS 634
             LG   +   G G   +A   G D  +EEEE   EG     G+Q+EL EE  A     S
Sbjct: 60  LDLGGDSAGRSGAGLEQEAAAGG-DEEEEEEEEEEEGISALDGDQMELGEENGAAGAADS 118

Query: 635 QPPPPEPKGDATPEGEKATEKENGD-----KSEAQKPSEKAEAGPEG----VAPAPEGEK 685
            P           E E A+E ENGD     + E +   E+  AG E       P P   +
Sbjct: 119 GP---------MEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQ 169

Query: 686 KQKPARKRRMVEE 698
           +Q+P ++R   +E
Sbjct: 170 QQQPQQQRGAAKE 182



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 35/144 (24%), Positives = 57/144 (39%), Gaps = 13/144 (9%)

Query: 565 EDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQV---E 621
           E+  EEE  ++ L      L        A ++G   ++EEE +  + + D+ G Q    E
Sbjct: 87  EEEEEEEEGISALDGDQMELGEENGAAGAADSGP--MEEEEAASEDENGDDQGFQEGEDE 144

Query: 622 LKEEAEAPVED---GSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVA 678
           L +E E   ++   G Q P P       P+ ++   KE   KS            P G  
Sbjct: 145 LGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGAR 204

Query: 679 PAP-----EGEKKQKPARKRRMVE 697
                   +G+ +QK   K+R V+
Sbjct: 205 QGQQQAGGDGKTEQKGGDKKRGVK 228


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.131    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,567,105
Number of Sequences: 37866
Number of extensions: 1991956
Number of successful extensions: 17502
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 891
Number of HSP's that attempted gapping in prelim test: 10629
Number of HSP's gapped (non-prelim): 5541
length of query: 999
length of database: 18,247,518
effective HSP length: 112
effective length of query: 887
effective length of database: 14,006,526
effective search space: 12423788562
effective search space used: 12423788562
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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