Guide to the Human Genome
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Search of human proteins with 5453810

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453810 netrin 3 [Homo sapiens]
         (580 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453810 netrin 3 [Homo sapiens]                                   1241   0.0  
gi|148613884 netrin 1 [Homo sapiens]                                  674   0.0  
gi|24308065 netrin 5 [Homo sapiens]                                   377   e-104
gi|145309326 laminin, gamma 1 precursor [Homo sapiens]                327   2e-89
gi|110611156 laminin, gamma 3 precursor [Homo sapiens]                306   4e-83
gi|93204871 netrin 4 [Homo sapiens]                                   228   2e-59
gi|119703755 laminin, beta 2 precursor [Homo sapiens]                 227   2e-59
gi|143770880 laminin, beta 4 [Homo sapiens]                           210   3e-54
gi|164414431 netrin G1 isoform 1 [Homo sapiens]                       199   8e-51
gi|167614504 laminin, beta 1 precursor [Homo sapiens]                 198   1e-50
gi|62868217 laminin, beta 3 precursor [Homo sapiens]                  196   5e-50
gi|62868215 laminin, beta 3 precursor [Homo sapiens]                  196   5e-50
gi|189083719 laminin, beta 3 precursor [Homo sapiens]                 196   5e-50
gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]          195   8e-50
gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]         195   8e-50
gi|190014607 netrin G2 [Homo sapiens]                                 194   1e-49
gi|21264602 laminin alpha 5 [Homo sapiens]                            193   4e-49
gi|38788416 laminin, alpha 1 precursor [Homo sapiens]                 190   3e-48
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s...   167   2e-41
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa...   167   2e-41
gi|219842266 usherin isoform B [Homo sapiens]                         163   5e-40
gi|219842259 usherin isoform A [Homo sapiens]                         163   5e-40
gi|54312078 netrin G1 isoform 3 [Homo sapiens]                        124   2e-28
gi|164414437 netrin G1 isoform 2 [Homo sapiens]                       123   5e-28
gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]      105   1e-22
gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]      105   1e-22
gi|189217428 laminin alpha 3 subunit isoform 4 [Homo sapiens]          96   1e-19
gi|38045908 laminin alpha 3 subunit isoform 2 [Homo sapiens]           96   1e-19
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             91   4e-18
gi|122937440 multiple EGF-like-domains 9 [Homo sapiens]                86   7e-17

>gi|5453810 netrin 3 [Homo sapiens]
          Length = 580

 Score = 1241 bits (3212), Expect = 0.0
 Identities = 580/580 (100%), Positives = 580/580 (100%)

Query: 1   MPGWPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCG 60
           MPGWPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCG
Sbjct: 1   MPGWPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCG 60

Query: 61  RPATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFV 120
           RPATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFV
Sbjct: 61  RPATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFV 120

Query: 121 SLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPA 180
           SLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPA
Sbjct: 121 SLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPA 180

Query: 181 PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVV 240
           PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVV
Sbjct: 181 PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVV 240

Query: 241 PYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRA 300
           PYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRA
Sbjct: 241 PYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRA 300

Query: 301 TARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRD 360
           TARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRD
Sbjct: 301 TARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRD 360

Query: 361 PGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAP 420
           PGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAP
Sbjct: 361 PGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAP 420

Query: 421 CVKTPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKFCKKDYAVQVAVGARGEARGAW 480
           CVKTPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKFCKKDYAVQVAVGARGEARGAW
Sbjct: 421 CVKTPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKFCKKDYAVQVAVGARGEARGAW 480

Query: 481 TRFPVAVLAVFRSGEERARRGSSALWVPAGDAACGCPRLLPGRRYLLLGGGPGAAAGGAG 540
           TRFPVAVLAVFRSGEERARRGSSALWVPAGDAACGCPRLLPGRRYLLLGGGPGAAAGGAG
Sbjct: 481 TRFPVAVLAVFRSGEERARRGSSALWVPAGDAACGCPRLLPGRRYLLLGGGPGAAAGGAG 540

Query: 541 GRGPGLIAARGSLVLPWRDAWTRRLRRLQRRERRGRCSAA 580
           GRGPGLIAARGSLVLPWRDAWTRRLRRLQRRERRGRCSAA
Sbjct: 541 GRGPGLIAARGSLVLPWRDAWTRRLRRLQRRERRGRCSAA 580


>gi|148613884 netrin 1 [Homo sapiens]
          Length = 604

 Score =  674 bits (1740), Expect = 0.0
 Identities = 314/580 (54%), Positives = 406/580 (70%), Gaps = 29/580 (5%)

Query: 22  GPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRPATR---------------- 65
           G  A  DPC DE G PR C+P  VNAA G++V  SSTCGRP  R                
Sbjct: 33  GQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCH 92

Query: 66  ACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFC 125
            C+ASDP++AH PA LT      +  CW+SE+  + P NVTLT+ LGK FE+ +VSL+FC
Sbjct: 93  LCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFC 152

Query: 126 SAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPL-AQ 184
           S  P S+A+ KS D+GR+W P  F+S+ C   Y R P  A        EA+C  +    +
Sbjct: 153 SPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNR-PHRAPITKQNEQEAVCTDSHTDMR 211

Query: 185 PDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVP--- 241
           P   GL+AFS  D  P   D D+SPVLQDWVTATD+RV  +R  T GD  + ++ +    
Sbjct: 212 PLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDS 271

Query: 242 YSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRAT 301
           Y YA +DLQVGGRCKCNGHA+RC+ D    L+CDCRH T GP+C RCKPF+ DRPWQRAT
Sbjct: 272 YFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRAT 331

Query: 302 ARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDP 361
           ARE++ C+AC+CN HARRCRFNMELY+LSGR+SGGVCLNCRHNTAGRHCHYC+EG+YRD 
Sbjct: 332 AREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDM 391

Query: 362 GRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPC 421
           G+ ++ R+AC+ACDCHPVGAAGKTCNQTTGQCPCKDGVTG+TCNRCA G+QQSRSP+APC
Sbjct: 392 GKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPC 451

Query: 422 VKTPIPGPTEDSSPV-QPQDCDSHCKPARGSYRISLKKFCKKDYAVQVAVGARGEARGAW 480
           +K P+  PT  +S V +P+DCDS+CK ++G  +I++KK+CKKDYAVQ+ +  + +  G W
Sbjct: 452 IKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHI-LKADKAGDW 510

Query: 481 TRFPVAVLAVFRSGEERARRGSSALWVPAGDAACGCPRLLPGRRYLLLGGGPGAAAGGAG 540
            +F V +++V++ G  R RRG  +LW+ + D AC CP++ P ++YLLLG    +      
Sbjct: 511 WKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQS-- 568

Query: 541 GRGPGLIAARGSLVLPWRDAWTRRLRRLQRRERRGRCSAA 580
               G++A + SLV+ WRD W RRLR+ Q+RE++G+C  A
Sbjct: 569 ----GIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA 604


>gi|24308065 netrin 5 [Homo sapiens]
          Length = 489

 Score =  377 bits (968), Expect = e-104
 Identities = 229/566 (40%), Positives = 283/566 (50%), Gaps = 99/566 (17%)

Query: 16  FAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRPATRACDASDPRRA 75
           FA L     A ADPC+D  G P+ C+P +   A                 A  AS P+  
Sbjct: 5   FALLLLLGQATADPCYDPQGRPQFCLPPVTQLA-----------------AVAASCPQ-- 45

Query: 76  HSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVALL 135
              A   SPG              R   N +LT+ LG  F L  VSLRFC+  P ++ L 
Sbjct: 46  ---ACALSPGNHLGA---------RETCNGSLTLALGGPFLLTSVSLRFCTPGPPALILS 93

Query: 136 KSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPLAQPDGSGLLAFSM 195
            +   G  W  L                PA   A  GPE + F                 
Sbjct: 94  AAWASGGPWRLLWH-------------RPAWPGALGGPERVTF----------------- 123

Query: 196 QDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRC 255
                      S+P  +  V A+ +RV     +                AA  L+  GRC
Sbjct: 124 ----------HSTPGPKATVAASHLRVEFGGQA--------------GLAAAGLR--GRC 157

Query: 256 KCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNG 315
           +C+GHA+RC    +    C CRH T GP C  C+P + D PW+ AT R  H CL CSCN 
Sbjct: 158 QCHGHAARCAARARPPR-CHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQ 216

Query: 316 HARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACD 375
           HARRCRFN EL+RLSG RSGGVC  CRH+TAGRHCHYC+ GF+RDP + +  RRACRAC 
Sbjct: 217 HARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQ 276

Query: 376 CHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSP 435
           CHP+GA G TCNQT+GQC CK GVTGLTCNRC PG+QQSRSP  PC + P    T  ++P
Sbjct: 277 CHPIGATGGTCNQTSGQCTCKLGVTGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLATTP 336

Query: 436 ----VQPQDCDSHCKPARGSYRISLKKFCKKDYAVQVAVGARGEARGAWTRFPVAVLAVF 491
                 PQ C ++C  +     +SL+++C++D+ ++  V A   A  AW R  V VLAV+
Sbjct: 337 GAYSSDPQ-CQNYCNMSDTRVHMSLRRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVY 395

Query: 492 RSGEERARRGSSALWVPAGDAACGCPRLLPGRRYLLLGGGPGAAAGGAGGRGPGLIAARG 551
           +   +  RRG    WVP  D  CGC RL PG  YLLLG   G            LI  R 
Sbjct: 396 KQRAQPVRRGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVG------DPDPTRLILDRH 449

Query: 552 SLVLPWRDAWTRRLRRLQRRERRGRC 577
            L LPWR  W R L+RLQ+ ER G C
Sbjct: 450 GLALPWRPRWARPLKRLQQEERAGGC 475


>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
          Length = 1609

 Score =  327 bits (837), Expect = 2e-89
 Identities = 176/444 (39%), Positives = 238/444 (53%), Gaps = 34/444 (7%)

Query: 4   WPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRP- 62
           WP   +L A    AA +    A  D C DEGG P+ C+P  VNAA    V+A++TCG P 
Sbjct: 18  WPVLAVLAA----AAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPP 73

Query: 63  --------------ATRACDASDPRRAHSPALLTSPGGTASPLCWRSESL---PRAPLNV 105
                         +   CDA  P   H  A LT     A    W+S+++    + P ++
Sbjct: 74  EEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSI 133

Query: 106 TLTVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPA 165
            LT+ LGKAF++ +V L+F ++ P S A+ K       W P  ++S  C+  Y +     
Sbjct: 134 NLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGF 193

Query: 166 NGPAGPGPEALCFPA-PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVL 224
               G   +ALC        P   G +AFS  +  P   + D+SPVLQ+WVTATD+RV L
Sbjct: 194 IRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTL 253

Query: 225 TRPSTAGDP--RDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEG 282
            R +T GD    D + +  Y YA +D  VGGRCKCNGHAS C+ +    L+C+C+H T G
Sbjct: 254 NRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYG 313

Query: 283 PDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCR 342
            DC +C PF+ DRPW+RATA  +  CL C CNG ++ C F+ ELYR +G   GG C NC+
Sbjct: 314 VDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGH--GGHCTNCQ 371

Query: 343 HNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGL 402
            NT G HC  CRE F+R     L +  AC +C C PVG+    C+ + G+C CK GV G 
Sbjct: 372 DNTDGAHCERCRENFFR-----LGNNEACSSCHCSPVGSLSTQCD-SYGRCSCKPGVMGD 425

Query: 403 TCNRCAPGFQQ-SRSPVAPCVKTP 425
            C+RC PGF   + +   PC   P
Sbjct: 426 KCDRCQPGFHSLTEAGCRPCSCDP 449



 Score = 92.8 bits (229), Expect = 8e-19
 Identities = 67/230 (29%), Positives = 91/230 (39%), Gaps = 41/230 (17%)

Query: 255 CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN 314
           C CNGH+  C  +T    +C+CR  T GP C +C   Y    +  +TA  S  C  C C 
Sbjct: 724 CACNGHSETCDPETG---VCNCRDNTAGPHCEKCSDGY----YGDSTAGTSSDCQPCPCP 776

Query: 315 GHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
           G +           +  +    VC NC   T G+ C  C +G++ DP       R CR C
Sbjct: 777 GGSSCA--------VVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLC 828

Query: 375 DCH---PVGAAGKTCNQTTGQC-PCKDGVTGLTCNRCAPGFQQSRSPVAPCVK------- 423
            C       A G  CN+ TG+C  C     G  C+RC  GF  +     P  K       
Sbjct: 829 QCSDNIDPNAVG-NCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCN 887

Query: 424 -----------TPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKFCKK 462
                       P+ G  E    V  QDC + C P  G Y +   + C++
Sbjct: 888 LYGTMKQQSSCNPVTGQCECLPHVTGQDCGA-CDP--GFYNLQSGQGCER 934



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 48/144 (33%), Positives = 58/144 (40%), Gaps = 28/144 (19%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARES--HACLACSCNGHARRCRFNMELYRLSG 331
           C C  G  G  C  C   Y     +R T        C+ C+CNGH+  C           
Sbjct: 690 CTCPVGYGGQFCEMCLSGY-----RRETPNLGPYSPCVLCACNGHSETC----------- 733

Query: 332 RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAA----GKTCN 387
               GVC NCR NTAG HC  C +G+Y D     S    C+ C C P G++     KT  
Sbjct: 734 DPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSS--DCQPCPC-PGGSSCAVVPKTKE 789

Query: 388 QTTGQCPCKDGVTGLTCNRCAPGF 411
                CP   G TG  C  C  G+
Sbjct: 790 VVCTNCP--TGTTGKRCELCDDGY 811



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 39/146 (26%), Positives = 56/146 (38%), Gaps = 29/146 (19%)

Query: 274  CDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332
            C+C     G DCG C P FY          +    C  C C+           L   +G+
Sbjct: 905  CECLPHVTGQDCGACDPGFY--------NLQSGQGCERCDCHA----------LGSTNGQ 946

Query: 333  RS--GGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTT 390
                 G C  C+    G+HC  C    +            C+ CDCHP G+    C    
Sbjct: 947  CDIRTGQC-ECQPGITGQHCERCEVNHFG------FGPEGCKPCDCHPEGSLSLQCKDD- 998

Query: 391  GQCPCKDGVTGLTCNRCAPGFQQSRS 416
            G+C C++G  G  C++C   +  +RS
Sbjct: 999  GRCECREGFVGNRCDQCEENYFYNRS 1024


>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
          Length = 1575

 Score =  306 bits (783), Expect = 4e-83
 Identities = 166/419 (39%), Positives = 219/419 (52%), Gaps = 32/419 (7%)

Query: 30  CHDEGGAPRGCVPGLVNAALGREVLASSTCGRPAT---------------RACDASDPRR 74
           C+D  G P+ C+P   NAA GR   AS TCG P                 + CDA+DP+R
Sbjct: 25  CYDGAGRPQRCLPVFENAAFGRLAQASHTCGSPPEDFCPHVGAAGAGAHCQRCDAADPQR 84

Query: 75  AHSPALLTSPGGTASPLCWRSESLP---RAPLNVTLTVPLGKAFELVFVSLRFCSAPPAS 131
            H+ + LT          W+S S+    + P +V +T+ LGKA+E+ +V L+F ++ P S
Sbjct: 85  HHNASYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPES 144

Query: 132 VALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPA-PLAQPDGSGL 190
            A+ K       W P  F+S+ C   YGR       P      A C        P   G 
Sbjct: 145 FAIYKRSRADGPWEPYQFYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGN 204

Query: 191 LAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDP--RDMEAVVPYSYAATD 248
           +AFS  +  P   + + SP LQ+WVT+T++ + L R +T GD   +D + +  Y YA +D
Sbjct: 205 VAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYYAVSD 264

Query: 249 LQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHAC 308
             VGGRCKCNGHAS C  D  G L C C+H T G DC RC PF+ DRPW R TA  +H C
Sbjct: 265 FSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHEC 324

Query: 309 LACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYR-DPGRALSD 367
           L C+C+G +  C F+ EL+R +G   GG C +CR +TAG HC  C+E FY  DP      
Sbjct: 325 LPCNCSGRSEECTFDRELFRSTGH--GGRCHHCRDHTAGPHCERCQENFYHWDP------ 376

Query: 368 RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQ-SRSPVAPCVKTP 425
           R  C+ CDC   G+    C+  TG C CK  VTG  C+RC PGF   S     PC   P
Sbjct: 377 RMPCQPCDCQSAGSLHLQCDD-TGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNP 434



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 94/331 (28%), Positives = 110/331 (33%), Gaps = 115/331 (34%)

Query: 180 APLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLT----RPSTAGDPRD 235
           +P   P G   L      S+ PGL   +S     WV         T         G  R+
Sbjct: 640 SPGPSPAGPVFLTEVRLTSARPGLSPPAS-----WVEICSCPTGYTGQFCESCAPGYKRE 694

Query: 236 MEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKP-FY-- 292
           M    PY+           C CN H + C  +T    IC C H TEGP C RC P FY  
Sbjct: 695 MPQGGPYASCVP-------CTCNQHGT-CDPNTG---ICVCSHHTEGPSCERCLPGFYGN 743

Query: 293 -----------CDRPWQRA--TARESH--ACLACSCNGHARRCR-----FNMELYRLSGR 332
                      C  P Q A  T  ES    C  C      RRC      F  +   L G 
Sbjct: 744 PFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGH 803

Query: 333 RS----------------------GGVCLNCRHNTAGRHCHYCREGFY------------ 358
                                    G CL C HNT G HC +C+EGFY            
Sbjct: 804 PQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKC 863

Query: 359 --------------------------------RDPGRA------LSDRRACRACDCHPVG 380
                                           RD  R       L   R CR+C CHP+G
Sbjct: 864 MPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLG 923

Query: 381 AAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
           +    C+  TGQC C+ GVTG  C+RC  GF
Sbjct: 924 SQEDQCHPKTGQCTCRPGVTGQACDRCQLGF 954



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 41/141 (29%), Positives = 57/141 (40%), Gaps = 29/141 (20%)

Query: 274  CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN---GHARRCRFNMELYRLS 330
            C C       DC RC P + D        +    C +C C+       +C          
Sbjct: 887  CSCLPHVTARDCSRCYPGFFD-------LQPGRGCRSCKCHPLGSQEDQCH--------- 930

Query: 331  GRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTT 390
                 G C  CR    G+ C  C+ GF+   G ++   + CRAC C P+GAA   C++  
Sbjct: 931  --PKTGQC-TCRPGVTGQACDRCQLGFF---GFSI---KGCRACRCSPLGAASAQCHE-N 980

Query: 391  GQCPCKDGVTGLTCNRCAPGF 411
            G C C+ G  G  C+RC   F
Sbjct: 981  GTCVCRPGFEGYKCDRCHDNF 1001


>gi|93204871 netrin 4 [Homo sapiens]
          Length = 628

 Score =  228 bits (580), Expect = 2e-59
 Identities = 187/652 (28%), Positives = 277/652 (42%), Gaps = 120/652 (18%)

Query: 8   LLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRPATRA- 66
           LLL   T+ AA   G    +  C       + C P + N ALGR++ A +TCG+ AT   
Sbjct: 8   LLLWGCTVVAAGLSGVAGVSSRCE------KACNPRMGNLALGRKLWADTTCGQNATELY 61

Query: 67  ------------------CDASDPRRAHSPALLTSPGGTASPLCWRS-ESLPRAPLNVTL 107
                             C+A+ P  AH P+ +           W+S E + R  + + L
Sbjct: 62  CFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDL 121

Query: 108 TVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANG 167
                  F    + + F S  PA++ L +SQD G++W P  +F+++C   +G        
Sbjct: 122 EAE----FYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVK- 176

Query: 168 PAGPGPEALC---FPAPLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRV-V 223
                  A+C   + +P   P   G + F    S P   +   S  +Q+ +  T++RV +
Sbjct: 177 -----KGAICTSKYSSPF--PCTGGEVIFKAL-SPPYDTENPYSAKVQEQLKITNLRVQL 228

Query: 224 LTRPSTAGDPRDMEAVVPY--SYAATDLQVGGRCKCNGHASRCL-------LDTQG--HL 272
           L R S      D+     +   YA  D  V G C CNGHA +C+       +   G  H+
Sbjct: 229 LKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHM 288

Query: 273 I---CDCRHGTEGPDCGRCKPFYCDRPWQRATARES--HACLACSCNGHARRCRFNMELY 327
           +   C C+H T G  C  C P Y DRPW+ A  +    + C  C CNGHA  C F++ ++
Sbjct: 289 VHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVW 348

Query: 328 RLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCN 387
             SG RSGGVC +C+HNT G++C  C+ GFYRD  R  S   AC+ C CHPVG+A    N
Sbjct: 349 EASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPAN 408

Query: 388 QTT------GQCPCKDGVTGLTCNRCAPGF-------------QQSRSPV-APCVKT--- 424
             T      G CPCK GV G  C+RC  G+               S  P+   C+ +   
Sbjct: 409 SVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTD 468

Query: 425 -----------PIPGPTED----------SSPVQPQDCDSHCKPARGSYRISLKKFC--K 461
                      P+   +E           S+ +    C+  CK        + K FC  K
Sbjct: 469 IDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCE--CKEQTLG---NAKAFCGMK 523

Query: 462 KDYAVQVAVGARGEARGAWTRFPVAVLAVFRSGEERARRGSSALWVPA-GDAACGCPRLL 520
             Y +++ +      +G      V +  V +S + +  RG   L+  +  D  C CP L 
Sbjct: 524 YSYVLKIKI-LSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILN 582

Query: 521 PGRRYLLLGGGPGAAAGGAGGRGPGLIAARGSLVLPWRDAWTRRLRRLQRRE 572
           PG  YL+        AG    R   LI    S V  W+ +  R++  + +RE
Sbjct: 583 PGLEYLV--------AGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRE 626


>gi|119703755 laminin, beta 2 precursor [Homo sapiens]
          Length = 1798

 Score =  227 bits (579), Expect = 2e-59
 Identities = 166/496 (33%), Positives = 223/496 (44%), Gaps = 70/496 (14%)

Query: 5   PW----GLLLTAGTLFAALSPGPPAPADPCHDEGGAPRG-CVPGLVNAALGR--EVLASS 57
           PW    GLLL+      A +P P  P        G  RG C P   +  +GR   + ASS
Sbjct: 15  PWELRLGLLLSVLAATLAQAPAPDVP--------GCSRGSCYPATGDLLVGRADRLTASS 66

Query: 58  TCGRPAT------------RACDASDPRRAHSPA----------LLTSPGGTASPLCWRS 95
           TCG                + C   D RR  S            ++TS         W+S
Sbjct: 67  TCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQS 126

Query: 96  ESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCD 155
           E+   A   VT+ + L   F    + + F +  PA++ + +S D GR+W    +FS  C 
Sbjct: 127 ENGIPA---VTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCG 183

Query: 156 LDYGRLPAPANGPAGPGPEALCFPA-PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDW 214
            D+  +P     P     + +C       +P   G + + + D + P  D  SS + Q+ 
Sbjct: 184 ADFPGVPL---APPRHWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSRI-QNL 239

Query: 215 VTATDVRVVLTRPSTAGD----PRDMEAVVPYSYAATDLQVGGRCKCNGHASRCL----- 265
           +  T++RV LTR  T GD    PR  E    Y YA  +L V G C C GHAS C      
Sbjct: 240 LKITNLRVNLTRLHTLGDNLLDPR-REIREKYYYALYELVVRGNCFCYGHASECAPAPGA 298

Query: 266 ---LDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRF 322
               +   H  C C+H T G +C +C+ FY D PW+ A    SHAC  C C+GH   C F
Sbjct: 299 PAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHF 358

Query: 323 NMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAA 382
           +M +Y  SG  SGGVC  C+HNTAGRHC  CR  FYRDP + L D   CR+CDC P+G+ 
Sbjct: 359 DMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQ 418

Query: 383 -GKTCNQ--------TTGQCPCKDGVTGLTCNRCAPG-FQQSRSPVAPC--VKTPIPGPT 430
            G  C+          +GQC CK+ V G  C +C  G F  S S    C   +    G  
Sbjct: 419 DGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTV 478

Query: 431 EDSSPVQPQDCDSHCK 446
             S+P  P     +CK
Sbjct: 479 PGSTPCDPNSGSCYCK 494



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 71/231 (30%), Positives = 89/231 (38%), Gaps = 40/231 (17%)

Query: 224  LTRPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGP 283
            L +P   G   D+ A   Y +  T  Q    C+C+   +   L  +    C CR G  G 
Sbjct: 803  LCKPGVVGRRCDLCAPGYYGFGPTGCQA---CQCSHEGALSSLCEKTSGQCLCRTGAFGL 859

Query: 284  DCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRH 343
             C RC+      P          +C  C CNGHA  C  +            G CL CR 
Sbjct: 860  RCDRCQRGQWGFP----------SCRPCVCNGHADECNTHT-----------GACLGCRD 898

Query: 344  NTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGK-----TCNQTTGQ----CP 394
            +T G HC  C  GF+ DP   L     CR C C P G   +     +C+Q        C 
Sbjct: 899  HTGGEHCERCIAGFHGDP--RLPYGGQCRPCPC-PEGPGSQRHFATSCHQDEYSQQIVCH 955

Query: 395  CKDGVTGLTCNRCAPG-FQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSH 444
            C+ G TGL C  CAPG F     P   C      G   +  P+ P  CD H
Sbjct: 956  CRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSG---NIDPMDPDACDPH 1003



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 56/176 (31%), Positives = 73/176 (41%), Gaps = 30/176 (17%)

Query: 254  RCKCN---GHASRCLLDTQGHLI-----CDCRHGTEGPDCGRCKPFYCDRPWQRATARES 305
            RC CN    +  +C    Q H       C C    +GP C RC P +    W   +    
Sbjct: 1037 RCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNF----WNLTSG--- 1089

Query: 306  HACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRAL 365
            H C  C+C  H  R R        +     G C +CR    GR C  C+E  + DPG   
Sbjct: 1090 HGCQPCAC--HPSRARGP------TCNEFTGQC-HCRAGFGGRTCSECQELHWGDPGLQ- 1139

Query: 366  SDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPC 421
                 C ACDC   G     C++ TG C C+ GV+G+ C++CA GF        PC
Sbjct: 1140 -----CHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPACHPC 1190



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 55/171 (32%), Positives = 70/171 (40%), Gaps = 37/171 (21%)

Query: 252  GGRCK---------------CNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRP 296
            GGRC+               C+ H  +CL          C H TEGP C  CKP +  + 
Sbjct: 980  GGRCQLCECSGNIDPMDPDACDPHTGQCLR---------CLHHTEGPHCAHCKPGFHGQ- 1029

Query: 297  WQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREG 356
                 AR+S  C  C+CN      +      +     S G C  C  N  G  C  C   
Sbjct: 1030 ----AARQS--CHRCTCNLLGTNPQQCPSPDQCHCDPSSGQC-PCLPNVQGPSCDRCAPN 1082

Query: 357  FYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRC 407
            F+      L+    C+ C CHP  A G TCN+ TGQC C+ G  G TC+ C
Sbjct: 1083 FWN-----LTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSEC 1128



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 56/222 (25%), Positives = 82/222 (36%), Gaps = 72/222 (32%)

Query: 254 RCKCNGHASRCLLDTQGHL--------ICD-CRHGTEGPDCGRCKPFYCDRPWQRATARE 304
           +C+C+GH   C  D   +L        +CD C+H T G  C  C+PF+   P +    R+
Sbjct: 346 KCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTK--DLRD 403

Query: 305 SHACLACSCNGHAR----RCRFNME--LYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358
              C +C C+        RC  + +  L  +SG+        C+ +  G  C  CR+GF+
Sbjct: 404 PAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQ------CRCKEHVVGTRCQQCRDGFF 457

Query: 359 R--------------------------DP------------GRALS-----------DRR 369
                                      DP            GR              D  
Sbjct: 458 GLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLL 517

Query: 370 ACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
            CR CDC   GA    C++ TGQC C+  + G  C +  PG+
Sbjct: 518 GCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGY 559



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 34/88 (38%), Positives = 41/88 (46%), Gaps = 8/88 (9%)

Query: 335 GGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCP 394
           GG CL C+    GR C  C  G+Y            C+AC C   GA    C +T+GQC 
Sbjct: 799 GGQCL-CKPGVVGRRCDLCAPGYYG------FGPTGCQACQCSHEGALSSLCEKTSGQCL 851

Query: 395 CKDGVTGLTCNRCAPGFQQSRSPVAPCV 422
           C+ G  GL C+RC  G Q       PCV
Sbjct: 852 CRTGAFGLRCDRCQRG-QWGFPSCRPCV 878



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 19/38 (50%), Positives = 23/38 (60%)

Query: 374 CDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
           C C+P G+    CN   GQC CK GV G  C+ CAPG+
Sbjct: 783 CQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGY 820



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 28/114 (24%), Positives = 42/114 (36%), Gaps = 29/114 (25%)

Query: 254 RCKCNGHASRCLLDTQGHLICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESH 306
           RC+CN   +       G   CD       C+    G  C RC P +    W    + +  
Sbjct: 469 RCQCNARGT-----VPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGH----W--GLSHDLL 517

Query: 307 ACLACSCN-GHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYR 359
            C  C C+ G A   + +            G C +CR +  GR C   + G++R
Sbjct: 518 GCRPCDCDVGGALDPQCD---------EGTGQC-HCRQHMVGRRCEQVQPGYFR 561


>gi|143770880 laminin, beta 4 [Homo sapiens]
          Length = 1761

 Score =  210 bits (534), Expect = 3e-54
 Identities = 135/421 (32%), Positives = 202/421 (47%), Gaps = 60/421 (14%)

Query: 40  CVPGLVNAALGR--EVLASSTCGRPATRA------------CDASDPRRAHSPA------ 79
           C P   +  +GR  +++ASSTCG    +             C   D R  + P       
Sbjct: 28  CHPTTGDLLVGRNTQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYDPYDQPNSH 87

Query: 80  ----LLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVALL 135
               ++ S         W+SE+      +V++ + L   F    + L F +  PA++ + 
Sbjct: 88  TIENVIVSFEPDREKKWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVE 144

Query: 136 KSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPL-AQPDGSGLLAFS 194
           +S D+G +W    +F+  C   +   P   +G A    + +C       +P   G +   
Sbjct: 145 RSTDYGHNWKVFKYFAKDCATSF---PNITSGQAQGVGDIVCDSKYSDIEPSTGGEVVLK 201

Query: 195 MQDSSPPGLDLDS--SPVLQDWVTATDVRVVLTRPSTAGDP----RDMEAVVPYSYAATD 248
           + D   P  ++++  SP +QD VT T++R+  T+  T GD     R  +++  Y YA  +
Sbjct: 202 VLD---PSFEIENPYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDSLDKYYYALYE 258

Query: 249 LQVGGRCKCNGHASRC---------LLDTQG--HLICDCRHGTEGPDCGRCKPFYCDRPW 297
           + V G C CNGHAS C         +    G  H  C C+H T+GP+C RCK F+ D PW
Sbjct: 259 MIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPW 318

Query: 298 QRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGF 357
           + A   + +AC +CSCN H+ RC F+M  Y  SG  SGGVC +C+HNT G+HC  CR  F
Sbjct: 319 RPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLF 378

Query: 358 YRDPGRALSDRRACRACDCHPVGA-AGKTC--------NQTTGQCPCKDGVTGLTCNRCA 408
           YRDP + +SD  AC  C+C P G  +G  C            GQC CK+ V G  C++C 
Sbjct: 379 YRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCK 438

Query: 409 P 409
           P
Sbjct: 439 P 439



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 68/204 (33%), Positives = 86/204 (42%), Gaps = 33/204 (16%)

Query: 272  LICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHA-CLACSCNGHARRCRFNMELYRL- 329
            +IC+C  G  G  CG C   +   P      R S A C  C+CN        N+++    
Sbjct: 936  VICNCLQGYTGTQCGECSTGFYGNP------RISGAPCQPCACNN-------NIDVTDPE 982

Query: 330  SGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCH---------PVG 380
            S  R  G CL C HNT G +C  C+ G Y   G AL+  + CR C CH         P G
Sbjct: 983  SCSRVTGECLRCLHNTQGANCQLCKPGHY---GSALN--QTCRRCSCHASGVSPMECPPG 1037

Query: 381  AAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQD 440
                 C+  TG CPC   VTGL C+RCA G+  +  P   C        T  SS      
Sbjct: 1038 GGACLCDPVTGACPCLPNVTGLACDRCADGY-WNLVPGRGCQSCDCDPRTSQSSHCDQLT 1096

Query: 441  CDSHCKPARGSYRISLKKFCKKDY 464
                CK   G  R S    C+++Y
Sbjct: 1097 GQCPCKLGYGGKRCS---ECQENY 1117



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 62/242 (25%), Positives = 88/242 (36%), Gaps = 95/242 (39%)

Query: 246 ATDLQVGG--RCKCNGHASRCLLDTQGHL--------IC-DCRHGTEGPDCGRCKPFYCD 294
           A DLQ      C CN H+SRC  D   +L        +C DC+H TEG  C RC+P +  
Sbjct: 321 AADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYR 380

Query: 295 RPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLN-------------- 340
            P +  T  + +AC+ C C+                G  SGG+C++              
Sbjct: 381 DPLK--TISDPYACIPCECDP--------------DGTISGGICVSHSDPALGSVAGQCL 424

Query: 341 CRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVG-------------------- 380
           C+ N  G  C  C+   Y   G + +D   C+ CDC+P+G                    
Sbjct: 425 CKENVEGAKCDQCKPNHY---GLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYV 481

Query: 381 -------------------------------AAGKTCNQTTGQCPCKDGVTGLTCNRCAP 409
                                          A    C+   GQC C+  VTG +C+  AP
Sbjct: 482 TGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAP 541

Query: 410 GF 411
           G+
Sbjct: 542 GY 543



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 57/194 (29%), Positives = 72/194 (37%), Gaps = 39/194 (20%)

Query: 241  PYSYAATDLQVGGRCKCNGHAS------------RCLLDTQGHLICDCRHGTEGPDCGRC 288
            P  Y +   Q   RC C  HAS             CL D      C C     G  C RC
Sbjct: 1008 PGHYGSALNQTCRRCSC--HASGVSPMECPPGGGACLCDPVTGA-CPCLPNVTGLACDRC 1064

Query: 289  KPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGR 348
               Y    W     R    C +C C+    +     +L         G C  C+    G+
Sbjct: 1065 ADGY----WNLVPGR---GCQSCDCDPRTSQSSHCDQLT--------GQC-PCKLGYGGK 1108

Query: 349  HCHYCREGFYRDP-GRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRC 407
             C  C+E +Y DP GR       C  CDC+  G     C+  TG C C++GV+G  C+RC
Sbjct: 1109 RCSECQENYYGDPPGR-------CIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRC 1161

Query: 408  APGFQQSRSPVAPC 421
            A G  Q       C
Sbjct: 1162 ARGHSQEFPTCLQC 1175



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 15/122 (12%)

Query: 290 PFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRH 349
           P  C+R     +A+     +AC C+               S  R GG C  C+    GR 
Sbjct: 748 PGACERLIISMSAKLHDGAVACKCHPQGS--------VGSSCSRLGGQC-QCKPLVVGRC 798

Query: 350 CHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAP 409
           C  C  G Y D G        C  C CHP G+    C+Q TGQCPC   V+G  C+RC  
Sbjct: 799 CDRCSTGSY-DLGH-----HGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLA 852

Query: 410 GF 411
           G+
Sbjct: 853 GY 854



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 61/233 (26%), Positives = 83/233 (35%), Gaps = 53/233 (22%)

Query: 255  CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN 314
            C C+   S+  +  Q    C C     G  C RC   Y   P          +C  C CN
Sbjct: 817  CHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFP----------SCHPCPCN 866

Query: 315  GHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
              A  C               G C NC   T GR+C  C +G+Y +P    S  + CR C
Sbjct: 867  RFAELCD-----------PETGSCFNCGGFTTGRNCERCIDGYYGNP----SSGQPCRPC 911

Query: 375  DCHPVGAAGK----TCNQTTGQ----CPCKDGVTGLTCNRCAPGF----QQSRSPVAPCV 422
             C    ++ +    +C Q        C C  G TG  C  C+ GF    + S +P  PC 
Sbjct: 912  LCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCA 971

Query: 423  KTPIPGPTEDSS-------------PVQPQDCDSHCKPARGSYRISLKKFCKK 462
                   T+  S               Q  +C   CKP  G Y  +L + C++
Sbjct: 972  CNNNIDVTDPESCSRVTGECLRCLHNTQGANCQL-CKP--GHYGSALNQTCRR 1021



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 48/174 (27%), Positives = 71/174 (40%), Gaps = 29/174 (16%)

Query: 310 ACSCNGHARRCRFNMELYRLSGRRSG---GVCLNCRHNTAGRHCHYCREGFYRDPGRALS 366
           +C CNGHA  CR   ++        G   G C+ C+HNT G +C  C++ F   P R  +
Sbjct: 264 SCFCNGHASECRPMQKMRGDVFSPPGMVHGQCV-CQHNTDGPNCERCKDFFQDAPWRPAA 322

Query: 367 DRR--ACRACDCHPV---------------GAAGKTCNQTTGQCPCKDGVTGLTCNRCAP 409
           D +  ACR+C C+                 G +G  C        C+    G  C+RC P
Sbjct: 323 DLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCED------CQHNTEGQHCDRCRP 376

Query: 410 GFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKFCKKD 463
            F +            IP   +    +    C SH  PA GS  ++ +  CK++
Sbjct: 377 LFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALGS--VAGQCLCKEN 428


>gi|164414431 netrin G1 isoform 1 [Homo sapiens]
          Length = 539

 Score =  199 bits (505), Expect = 8e-51
 Identities = 127/395 (32%), Positives = 184/395 (46%), Gaps = 52/395 (13%)

Query: 58  TCGRP------------ATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPR--APL 103
           TCG P                CDAS P  AH P L+    G      W+S +      PL
Sbjct: 71  TCGDPPETFCAMGNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPL 130

Query: 104 NVTLTVPLGKAFELVF-VSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLP 162
            V +T+   K  EL   + + F S  P  + L KS D+GR+W P  ++++ C LD   + 
Sbjct: 131 QVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDC-LDAFHMD 189

Query: 163 APANGPAGPGP--EALCFPA-PLAQPDGSGLLAFSMQDS----SPPGL--------DLDS 207
             +          E +C           S ++ F ++D     + P L         LD+
Sbjct: 190 PKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASLYGQLDT 249

Query: 208 SPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLD 267
           +  L+D+ T TD+R+ L RP+      D   +  Y YA +D++V GRCKCN HA+ C+ D
Sbjct: 250 TKKLRDFFTVTDLRIRLLRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNLHATVCVYD 309

Query: 268 TQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRAT-----ARESHACLA-------CSCNG 315
               L C+C H T GPDCG+CK  Y  RPW   +        ++ C+        C C G
Sbjct: 310 NS-KLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFG 368

Query: 316 HARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACD 375
           H+ RC +   L  +       +C++C+HNT G+HC  CR G++R+    L D   C  C 
Sbjct: 369 HSNRCSYIDLLNTV-------ICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECY 421

Query: 376 CHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
           C+P+G+    CN  +G C CK G TG  C+ C PG
Sbjct: 422 CNPLGSIHDRCN-GSGFCECKTGTTGPKCDECLPG 455


>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
          Length = 1786

 Score =  198 bits (503), Expect = 1e-50
 Identities = 144/491 (29%), Positives = 215/491 (43%), Gaps = 61/491 (12%)

Query: 7   GLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGR--EVLASSTCG--RP 62
           GLL      F AL        +P    G A   C P   +  +GR  ++  +STCG  +P
Sbjct: 2   GLLQLLAFSFLALCRARVRAQEPEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKP 61

Query: 63  ATRA-------------CDASDPRRAH---SPALLTSPGGTASP----LCWRSESLPRAP 102
                            C++ DP          L+ +   T +P    + W+SE+     
Sbjct: 62  EPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQSEN---GV 118

Query: 103 LNVTLTVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLP 162
            NVT+ + L   F    + + F +  PA++ + +S D G++W    +F+  C+  +   P
Sbjct: 119 ENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASF---P 175

Query: 163 APANGPAGPGPEALCFPAPL-AQPDGSGLLAFSMQDSSPPGLDLDS--SPVLQDWVTATD 219
             + GP     + +C       +P   G + F   D   P   ++   SP +Q+ +  T+
Sbjct: 176 GISTGPMKKVDDIICDSRYSDIEPSTEGEVIFRALD---PAFKIEDPYSPRIQNLLKITN 232

Query: 220 VRVVLTRPSTAGD---PRDMEAVVPYSYAATDLQVGGRCKCNGHASRCL--------LDT 268
           +R+   +  T GD      ME    Y YA  D+ V G C C GHAS C         ++ 
Sbjct: 233 LRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGHASECAPVDGFNEEVEG 292

Query: 269 QGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYR 328
             H  C CRH T+G +C  C  FY D PW+ A  R S+AC  C+CN H+  C F+M +Y 
Sbjct: 293 MVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYL 352

Query: 329 LSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGK-TCN 387
            +G  SGGVC +C+HNT GR+C  C+  +Y+ P R + D   C  C C P G+  +  C+
Sbjct: 353 ATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICD 412

Query: 388 QTT--------GQCPCKDGVTGLTCNRCAPGFQ--QSRSPVA--PCVKTPIPGPTEDSSP 435
             T        GQC CK  V G  C+ C  GF    S  P     C   P+ G     +P
Sbjct: 413 SYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPL-GTIPGGNP 471

Query: 436 VQPQDCDSHCK 446
              +    +CK
Sbjct: 472 CDSETGHCYCK 482



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 53/170 (31%), Positives = 68/170 (40%), Gaps = 32/170 (18%)

Query: 252  GGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLAC 311
            G  C+C+    +CL          C     G +C RC P      WQ A+      C  C
Sbjct: 1042 GSDCQCDKATGQCL----------CLPNVIGQNCDRCAP----NTWQLASGT---GCDPC 1084

Query: 312  SCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRAC 371
            +CN            +  S     G C  C     GR C  C+E F+ DP         C
Sbjct: 1085 NCNA--------AHSFGPSCNEFTGQC-QCMPGFGGRTCSECQELFWGDPDVE------C 1129

Query: 372  RACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPC 421
            RACDC P G     C+Q+TGQC C +GV G  C++C  G+        PC
Sbjct: 1130 RACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPC 1179



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 61/225 (27%), Positives = 87/225 (38%), Gaps = 65/225 (28%)

Query: 255  CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFY--------------CDRPWQRA 300
            C+CNGHA  C  D       +C+  T G +C RC   Y              C  P    
Sbjct: 867  CQCNGHADDC--DPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPD 924

Query: 301  TARE-SHAC--------LACSCN-----------------------GHARRCRFNMELYR 328
            + R+ + +C        LAC C+                       G  + C+ +  +  
Sbjct: 925  SGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDT 984

Query: 329  LSGR---RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKT 385
                   +  G CL C ++T G HC +CR G+Y D     + ++ CR C C+ +G   + 
Sbjct: 985  TDPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGD-----ALQQDCRKCVCNYLGTVQEH 1039

Query: 386  CN-------QTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVA--PC 421
            CN       + TGQC C   V G  C+RCAP   Q  S     PC
Sbjct: 1040 CNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPC 1084



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 59/217 (27%), Positives = 78/217 (35%), Gaps = 57/217 (26%)

Query: 274  CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
            C C  G     C RC P +   P          +C  C CNGHA  C             
Sbjct: 840  CHCFQGVYARQCDRCLPGHWGFP----------SCQPCQCNGHADDCD-----------P 878

Query: 334  SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQ- 392
              G CLNC+  T G +C  C  G+Y DP     D   CR C C     +G+   ++  Q 
Sbjct: 879  VTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDH--CRPCPCPDGPDSGRQFARSCYQD 936

Query: 393  -------CPCKDGVTGLTCNRCAPGFQQSRSPVA----PCVKTPIPGPTEDSSPVQPQDC 441
                   C C  G  G  C+ CA G+  + S V     PC          +     P+ C
Sbjct: 937  PVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPC------QCHNNIDTTDPEAC 990

Query: 442  D---------------SHCKPAR-GSYRISLKKFCKK 462
            D                HC+  R G Y  +L++ C+K
Sbjct: 991  DKETGRCLKCLYHTEGEHCQFCRFGYYGDALQQDCRK 1027



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 37/103 (35%), Positives = 44/103 (42%), Gaps = 11/103 (10%)

Query: 334 SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQC 393
           +GG C  CR N  GR C+ C       PG        C+ C+CH  G+    CN  TGQC
Sbjct: 788 NGGQC-QCRPNVVGRTCNRCA------PGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQC 840

Query: 394 PCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPV 436
            C  GV    C+RC PG     S    C      G  +D  PV
Sbjct: 841 HCFQGVYARQCDRCLPGHWGFPS----CQPCQCNGHADDCDPV 879



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 31/91 (34%), Positives = 38/91 (41%), Gaps = 12/91 (13%)

Query: 373 ACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG-FQQSRSPVAPC---------- 421
           AC+C P G+    C+   GQC C+  V G TCNRCAPG F    S   PC          
Sbjct: 772 ACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 422 VKTPIPGPTEDSSPVQPQDCDSHCKPARGSY 452
              P+ G       V  + CD  C P    +
Sbjct: 832 FCNPVTGQCHCFQGVYARQCD-RCLPGHWGF 861



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 25/90 (27%), Positives = 36/90 (40%), Gaps = 19/90 (21%)

Query: 270 GHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN-GHARRCRFNMELYR 328
           GH  C C+    G  C +C P +    W    + +   C  C C+ G A     N   + 
Sbjct: 477 GH--CYCKRLVTGQHCDQCLPEH----W--GLSNDLDGCRPCDCDLGGA----LNNSCFA 524

Query: 329 LSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358
            SG+ S      CR +  GR C+    G+Y
Sbjct: 525 ESGQCS------CRPHMIGRQCNEVEPGYY 548


>gi|62868217 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  196 bits (498), Expect = 5e-50
 Identities = 127/414 (30%), Positives = 196/414 (47%), Gaps = 45/414 (10%)

Query: 31  HDEGGAPRG-CVPGLVNAALGRE--VLASSTCG--RPATRA------------CDASDPR 73
           H +    RG C P + +  +GR   + ASSTCG  +P T              CD+  P 
Sbjct: 16  HAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRQPH 75

Query: 74  RAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVA 133
             +S  +  +   ++ P+ W        P  V+L + L + F+L  V + F    PA + 
Sbjct: 76  NYYSHRV-ENVASSSGPMRWWQSQNDVNP--VSLQLDLDRRFQLQEVMMEFQGPMPAGML 132

Query: 134 LLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPLAQPDG---SGL 190
           + +S D G++W    + ++ C   + R+     G      +  C   P  +P+     G 
Sbjct: 133 IERSSDFGKTWRVYQYLAADCTSTFPRV---RQGRPQSWQDVRCQSLP-QRPNARLNGGK 188

Query: 191 LAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYS--YAATD 248
           +  ++ D    G+    S  +Q+    T++RV  TR +    P       P S  YA + 
Sbjct: 189 VQLNLMDLVS-GIPATQSQKIQEVGEITNLRVNFTRLA----PVPQRGYHPPSAYYAVSQ 243

Query: 249 LQVGGRCKCNGHASRCL----------LDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQ 298
           L++ G C C+GHA RC              Q H +C C+H T GP+C RC PFY +RPW+
Sbjct: 244 LRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR 303

Query: 299 RATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358
            A  +++H C  C CNGH+  C F+  ++  S    GGVC NCR +T G++C  C+  ++
Sbjct: 304 PAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363

Query: 359 RDPGRALSDRRACRACDCHPVGAA-GKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
           R+     S +  C +C+C P GA  G  C+  TGQC CK+ V G  C+ C PGF
Sbjct: 364 RNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 59/213 (27%), Positives = 79/213 (37%), Gaps = 70/213 (32%)

Query: 254 RCKCNGHASRCLLD------TQGHL--ICD-CRHGTEGPDCGRCKPFYCDRPWQRATARE 304
           RC CNGH+  C  D      +QG    +CD CR  TEG +C RC+  Y       A+ +E
Sbjct: 315 RCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQE 374

Query: 305 SHACLACSCNGHA-------------------------------------------RRCR 321
           +  C++C C+                                               RC 
Sbjct: 375 T--CISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCD 432

Query: 322 FNMELYRLSGRRS------GGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACD 375
            N+    L  RR        G CL C  N  G  C  C    ++     L+  + C  C 
Sbjct: 433 CNI----LGSRRDMPCDEESGRCL-CLPNVVGPKCDQCAPYHWK-----LASGQGCEPCA 482

Query: 376 CHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCA 408
           C P  +    CNQ TGQCPC++G  GL C+  A
Sbjct: 483 CDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA 515



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 51/183 (27%), Positives = 80/183 (43%), Gaps = 37/183 (20%)

Query: 254 RCKCNGHASRCLLDTQGHLICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESH 306
           RC CN      +L ++  + CD       C     GP C +C P++    W+ A+ +   
Sbjct: 430 RCDCN------ILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH----WKLASGQ--- 476

Query: 307 ACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS 366
            C  C+C+ H      + +  + +G+        CR    G  C        + P R   
Sbjct: 477 GCEPCACDPHNS---LSPQCNQFTGQ------CPCREGFGGLMCSAA--AIRQCPDRTYG 525

Query: 367 D-RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVA----PC 421
           D    CRACDC   G  G  C++ +G+C C+ G+TG  C++C  G+  +R PV     PC
Sbjct: 526 DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY-CNRYPVCVACHPC 584

Query: 422 VKT 424
            +T
Sbjct: 585 FQT 587



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 42/152 (27%), Positives = 60/152 (39%), Gaps = 26/152 (17%)

Query: 310 ACSCNGHARRC--RFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS- 366
           +C C+GHA RC  +        +  +   VC+ C+HNTAG +C  C   +   P R    
Sbjct: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEG 307

Query: 367 -DRRACRACDCH---------------PVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
            D   C+ CDC+                 GA G  C+       C+D   G  C RC   
Sbjct: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHTEGKNCERCQLH 361

Query: 411 FQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCD 442
           + ++R P A   +T I    +    V    CD
Sbjct: 362 YFRNRRPGASIQETCISCECDPDGAVPGAPCD 393


>gi|62868215 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  196 bits (498), Expect = 5e-50
 Identities = 127/414 (30%), Positives = 196/414 (47%), Gaps = 45/414 (10%)

Query: 31  HDEGGAPRG-CVPGLVNAALGRE--VLASSTCG--RPATRA------------CDASDPR 73
           H +    RG C P + +  +GR   + ASSTCG  +P T              CD+  P 
Sbjct: 16  HAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRQPH 75

Query: 74  RAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVA 133
             +S  +  +   ++ P+ W        P  V+L + L + F+L  V + F    PA + 
Sbjct: 76  NYYSHRV-ENVASSSGPMRWWQSQNDVNP--VSLQLDLDRRFQLQEVMMEFQGPMPAGML 132

Query: 134 LLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPLAQPDG---SGL 190
           + +S D G++W    + ++ C   + R+     G      +  C   P  +P+     G 
Sbjct: 133 IERSSDFGKTWRVYQYLAADCTSTFPRV---RQGRPQSWQDVRCQSLP-QRPNARLNGGK 188

Query: 191 LAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYS--YAATD 248
           +  ++ D    G+    S  +Q+    T++RV  TR +    P       P S  YA + 
Sbjct: 189 VQLNLMDLVS-GIPATQSQKIQEVGEITNLRVNFTRLA----PVPQRGYHPPSAYYAVSQ 243

Query: 249 LQVGGRCKCNGHASRCL----------LDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQ 298
           L++ G C C+GHA RC              Q H +C C+H T GP+C RC PFY +RPW+
Sbjct: 244 LRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR 303

Query: 299 RATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358
            A  +++H C  C CNGH+  C F+  ++  S    GGVC NCR +T G++C  C+  ++
Sbjct: 304 PAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363

Query: 359 RDPGRALSDRRACRACDCHPVGAA-GKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
           R+     S +  C +C+C P GA  G  C+  TGQC CK+ V G  C+ C PGF
Sbjct: 364 RNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 59/213 (27%), Positives = 79/213 (37%), Gaps = 70/213 (32%)

Query: 254 RCKCNGHASRCLLD------TQGHL--ICD-CRHGTEGPDCGRCKPFYCDRPWQRATARE 304
           RC CNGH+  C  D      +QG    +CD CR  TEG +C RC+  Y       A+ +E
Sbjct: 315 RCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQE 374

Query: 305 SHACLACSCNGHA-------------------------------------------RRCR 321
           +  C++C C+                                               RC 
Sbjct: 375 T--CISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCD 432

Query: 322 FNMELYRLSGRRS------GGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACD 375
            N+    L  RR        G CL C  N  G  C  C    ++     L+  + C  C 
Sbjct: 433 CNI----LGSRRDMPCDEESGRCL-CLPNVVGPKCDQCAPYHWK-----LASGQGCEPCA 482

Query: 376 CHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCA 408
           C P  +    CNQ TGQCPC++G  GL C+  A
Sbjct: 483 CDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA 515



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 51/183 (27%), Positives = 80/183 (43%), Gaps = 37/183 (20%)

Query: 254 RCKCNGHASRCLLDTQGHLICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESH 306
           RC CN      +L ++  + CD       C     GP C +C P++    W+ A+ +   
Sbjct: 430 RCDCN------ILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH----WKLASGQ--- 476

Query: 307 ACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS 366
            C  C+C+ H      + +  + +G+        CR    G  C        + P R   
Sbjct: 477 GCEPCACDPHNS---LSPQCNQFTGQ------CPCREGFGGLMCSAA--AIRQCPDRTYG 525

Query: 367 D-RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVA----PC 421
           D    CRACDC   G  G  C++ +G+C C+ G+TG  C++C  G+  +R PV     PC
Sbjct: 526 DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY-CNRYPVCVACHPC 584

Query: 422 VKT 424
            +T
Sbjct: 585 FQT 587



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 42/152 (27%), Positives = 60/152 (39%), Gaps = 26/152 (17%)

Query: 310 ACSCNGHARRC--RFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS- 366
           +C C+GHA RC  +        +  +   VC+ C+HNTAG +C  C   +   P R    
Sbjct: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEG 307

Query: 367 -DRRACRACDCH---------------PVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
            D   C+ CDC+                 GA G  C+       C+D   G  C RC   
Sbjct: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHTEGKNCERCQLH 361

Query: 411 FQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCD 442
           + ++R P A   +T I    +    V    CD
Sbjct: 362 YFRNRRPGASIQETCISCECDPDGAVPGAPCD 393


>gi|189083719 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  196 bits (498), Expect = 5e-50
 Identities = 127/414 (30%), Positives = 196/414 (47%), Gaps = 45/414 (10%)

Query: 31  HDEGGAPRG-CVPGLVNAALGRE--VLASSTCG--RPATRA------------CDASDPR 73
           H +    RG C P + +  +GR   + ASSTCG  +P T              CD+  P 
Sbjct: 16  HAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRQPH 75

Query: 74  RAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVA 133
             +S  +  +   ++ P+ W        P  V+L + L + F+L  V + F    PA + 
Sbjct: 76  NYYSHRV-ENVASSSGPMRWWQSQNDVNP--VSLQLDLDRRFQLQEVMMEFQGPMPAGML 132

Query: 134 LLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPLAQPDG---SGL 190
           + +S D G++W    + ++ C   + R+     G      +  C   P  +P+     G 
Sbjct: 133 IERSSDFGKTWRVYQYLAADCTSTFPRV---RQGRPQSWQDVRCQSLP-QRPNARLNGGK 188

Query: 191 LAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYS--YAATD 248
           +  ++ D    G+    S  +Q+    T++RV  TR +    P       P S  YA + 
Sbjct: 189 VQLNLMDLVS-GIPATQSQKIQEVGEITNLRVNFTRLA----PVPQRGYHPPSAYYAVSQ 243

Query: 249 LQVGGRCKCNGHASRCL----------LDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQ 298
           L++ G C C+GHA RC              Q H +C C+H T GP+C RC PFY +RPW+
Sbjct: 244 LRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR 303

Query: 299 RATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358
            A  +++H C  C CNGH+  C F+  ++  S    GGVC NCR +T G++C  C+  ++
Sbjct: 304 PAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363

Query: 359 RDPGRALSDRRACRACDCHPVGAA-GKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
           R+     S +  C +C+C P GA  G  C+  TGQC CK+ V G  C+ C PGF
Sbjct: 364 RNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 59/213 (27%), Positives = 79/213 (37%), Gaps = 70/213 (32%)

Query: 254 RCKCNGHASRCLLD------TQGHL--ICD-CRHGTEGPDCGRCKPFYCDRPWQRATARE 304
           RC CNGH+  C  D      +QG    +CD CR  TEG +C RC+  Y       A+ +E
Sbjct: 315 RCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQE 374

Query: 305 SHACLACSCNGHA-------------------------------------------RRCR 321
           +  C++C C+                                               RC 
Sbjct: 375 T--CISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCD 432

Query: 322 FNMELYRLSGRRS------GGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACD 375
            N+    L  RR        G CL C  N  G  C  C    ++     L+  + C  C 
Sbjct: 433 CNI----LGSRRDMPCDEESGRCL-CLPNVVGPKCDQCAPYHWK-----LASGQGCEPCA 482

Query: 376 CHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCA 408
           C P  +    CNQ TGQCPC++G  GL C+  A
Sbjct: 483 CDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA 515



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 51/183 (27%), Positives = 80/183 (43%), Gaps = 37/183 (20%)

Query: 254 RCKCNGHASRCLLDTQGHLICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESH 306
           RC CN      +L ++  + CD       C     GP C +C P++    W+ A+ +   
Sbjct: 430 RCDCN------ILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYH----WKLASGQ--- 476

Query: 307 ACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS 366
            C  C+C+ H      + +  + +G+        CR    G  C        + P R   
Sbjct: 477 GCEPCACDPHNS---LSPQCNQFTGQ------CPCREGFGGLMCSAA--AIRQCPDRTYG 525

Query: 367 D-RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVA----PC 421
           D    CRACDC   G  G  C++ +G+C C+ G+TG  C++C  G+  +R PV     PC
Sbjct: 526 DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGY-CNRYPVCVACHPC 584

Query: 422 VKT 424
            +T
Sbjct: 585 FQT 587



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 42/152 (27%), Positives = 60/152 (39%), Gaps = 26/152 (17%)

Query: 310 ACSCNGHARRC--RFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS- 366
           +C C+GHA RC  +        +  +   VC+ C+HNTAG +C  C   +   P R    
Sbjct: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEG 307

Query: 367 -DRRACRACDCH---------------PVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
            D   C+ CDC+                 GA G  C+       C+D   G  C RC   
Sbjct: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHTEGKNCERCQLH 361

Query: 411 FQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCD 442
           + ++R P A   +T I    +    V    CD
Sbjct: 362 YFRNRRPGASIQETCISCECDPDGAVPGAPCD 393


>gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]
          Length = 3333

 Score =  195 bits (496), Expect = 8e-50
 Identities = 132/419 (31%), Positives = 198/419 (47%), Gaps = 48/419 (11%)

Query: 67  CDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPL--NVTLTVPLGKAFELVFVSLRF 124
           C++ DPR+AH P      G   S   W+S  L        V LT+ LG+ F + ++ ++F
Sbjct: 105 CNSEDPRKAH-PVTNAIDG---SERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKF 160

Query: 125 CSAP-PASVALLKSQDHGRSWAPLGFFSSH---CDLDYGRLPAPANGPAGPGPEALCFPA 180
            ++P P    L +S D G +++P  +F+     C  ++GR    AN       + LC   
Sbjct: 161 ANSPRPDLWVLERSVDFGSTYSPWQYFAHSKVDCLKEFGR---EANMAVTRDDDVLCVTE 217

Query: 181 -PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPST------AGDP 233
                P  +G +  S+ +  P   +   S  L+++  AT++R+   R +T      +   
Sbjct: 218 YSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQ 277

Query: 234 RDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLI-CDCRHGTEGPDCGRCKPFY 292
           RD      Y Y+  D+ +GG+C CNGHA  C ++    L  C+C+H T G  C RC   Y
Sbjct: 278 RDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGY 337

Query: 293 CDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR-------RSGGVCLNCRHNT 345
             R W+ A   +SH C AC+C+GHA  C ++ ++ R             GGVC+NC+HNT
Sbjct: 338 NQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNT 397

Query: 346 AGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCN 405
           AG +C  C +G+YR  G  +     C  C C P  A G  C Q +G+C CK    G  C 
Sbjct: 398 AGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADG--CEQGSGRCHCKPNFHGDNCE 455

Query: 406 RCAPGFQQ----SRSPVAPCVKTP---------IPGPTEDSSPVQPQDCDSH----CKP 447
           +CA G+       R P+ P V TP         I G   +   V P+ CD+H    C+P
Sbjct: 456 KCAIGYYNFPFCLRIPIFP-VSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRP 513



 Score =  103 bits (257), Expect = 4e-22
 Identities = 67/192 (34%), Positives = 85/192 (44%), Gaps = 41/192 (21%)

Query: 273  ICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332
            IC C     G  C  C P Y        T R    C+ C+CNGH+ +C+           
Sbjct: 1653 ICACPPAYAGDSCQGCSPGYYRDHKGLYTGR----CVPCNCNGHSNQCQ----------- 1697

Query: 333  RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVG--AAGKTCNQTT 390
               G+C+NC+HNTAG HC  C+EG+Y   G A+    +CRAC C      A G   N   
Sbjct: 1698 DGSGICVNCQHNTAGEHCERCQEGYY---GNAV--HGSCRACPCPHTNSFATGCVVNGGD 1752

Query: 391  GQCPCKDGVTGLTCNRCAPGF----QQSRSPVAPCVKT---------PIPG-----PTED 432
             +C CK G TG  C RCAPG+    Q+      PC            P+ G       +D
Sbjct: 1753 VRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKD 1812

Query: 433  SSPVQP-QDCDS 443
            SSP +   DCDS
Sbjct: 1813 SSPAEECDDCDS 1824



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 53/163 (32%), Positives = 68/163 (41%), Gaps = 23/163 (14%)

Query: 255 CKCNG-HASRCLLDTQGHLICDCRHGTEGPDCGRCK------PFYCDRPWQRATARESHA 307
           C C+  HA  C    QG   C C+    G +C +C       PF    P    +   S  
Sbjct: 426 CSCDPEHADGC---EQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSED 482

Query: 308 CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSD 367
            +A    G  + C  N+E        + G CL CR    G  C  CR GFY  P      
Sbjct: 483 PVA----GDIKGCDCNLEGVLPEICDAHGRCL-CRPGVEGPRCDTCRSGFYSFP------ 531

Query: 368 RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
              C+AC C  +G+    C+  TGQC C+ GVTG  C+RC  G
Sbjct: 532 --ICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSG 572



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 45/159 (28%), Positives = 64/159 (40%), Gaps = 30/159 (18%)

Query: 257 CNGHASRCLLDTQGHL-----ICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLAC 311
           C G +S C  D  G +      C C+   EGP C RCK  Y    W       S  C  C
Sbjct: 579 CQGSSSAC--DPAGTINSNLGYCQCKLHVEGPTCSRCKLLY----WNLDKENPS-GCSEC 631

Query: 312 SCNGHARRCRFNMELYRLSG----RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSD 367
            C+          +   +SG    R+  G C +C+ +  G  C  C +G++       S+
Sbjct: 632 KCH----------KAGTVSGTGECRQGDGDC-HCKSHVGGDSCDTCEDGYF---ALEKSN 677

Query: 368 RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNR 406
              C+ C C   GA    C+  +G C C++ V G  C R
Sbjct: 678 YFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQR 716



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 55/198 (27%), Positives = 77/198 (38%), Gaps = 30/198 (15%)

Query: 217  ATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRC---KCNGHASRCLLDTQGHLI 273
            A  V +    P+ AGD    +   P  Y        GRC    CNGH+++C     G  I
Sbjct: 1648 ALAVEICACPPAYAGD--SCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQC---QDGSGI 1702

Query: 274  C-DCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332
            C +C+H T G  C RC+  Y    +  A      AC     N  A  C  N         
Sbjct: 1703 CVNCQHNTAGEHCERCQEGY----YGNAVHGSCRACPCPHTNSFATGCVVN--------- 1749

Query: 333  RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQ 392
              G V  +C+    G  C  C  G++ +P +      +C+ C C+  G  G +C+  TG 
Sbjct: 1750 -GGDVRCSCKAGYTGTQCERCAPGYFGNPQKF---GGSCQPCSCNSNGQLG-SCHPLTGD 1804

Query: 393  C---PCKDGVTGLTCNRC 407
            C     KD      C+ C
Sbjct: 1805 CINQEPKDSSPAEECDDC 1822



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 51/176 (28%), Positives = 66/176 (37%), Gaps = 33/176 (18%)

Query: 252  GGRCKC--NGHASRCLLDTQGHL------ICDCRHGTEGPDCGRCK-PFYCDRPWQRATA 302
            GG+C C  N    +C     GH        C C         G+C+ P    RP  +   
Sbjct: 1282 GGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCRCPPRTVRP--QCEV 1339

Query: 303  RESHA--------CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCR 354
             E+H+        C  C+C+      R  +E       R  G C  C+    GR C  C 
Sbjct: 1340 CETHSFSFHPMAGCEGCNCSR-----RGTIEAAMPECDRDSGQC-RCKPRITGRQCDRCA 1393

Query: 355  EGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
             GFYR P         C  C+C+  G     C+  TG C CK+ V G  CN C  G
Sbjct: 1394 SGFYRFP--------ECVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCREG 1441



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 54/186 (29%), Positives = 66/186 (35%), Gaps = 32/186 (17%)

Query: 248  DLQVGGRCKCNGHASRCLLDTQGHLICDCRH-GTEGPDCGR------CKPFYCDRPWQR- 299
            D Q   R   N   S      +G L C+C   G  GP C        C+P    R   R 
Sbjct: 1240 DPQTASRFCKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRC 1299

Query: 300  ATARESHA-CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358
            AT       C  CSC    R C               G C  C   T    C  C    +
Sbjct: 1300 ATGHYGFPRCKPCSCG--RRLCE-----------EMTGQC-RCPPRTVRPQCEVCETHSF 1345

Query: 359  RDPGRALSDRRACRACDCHPVG---AAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSR 415
                 +      C  C+C   G   AA   C++ +GQC CK  +TG  C+RCA GF +  
Sbjct: 1346 -----SFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFP 1400

Query: 416  SPVAPC 421
              V PC
Sbjct: 1401 ECV-PC 1405



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 51/218 (23%), Positives = 70/218 (32%), Gaps = 64/218 (29%)

Query: 239 VVPYSYAATDLQVGGRCK-CNGHASRCLLDT-QGHLICDCRHGTEGPDCGRCKPFYCDRP 296
           + P S  +++  V G  K C+ +    L +    H  C CR G EGP C  C+  +   P
Sbjct: 472 IFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFP 531

Query: 297 WQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREG 356
                      C AC C+         +  Y++      G C  CR    G+ C  C  G
Sbjct: 532 ----------ICQACWCSA--------LGSYQMPCSSVTGQC-ECRPGVTGQRCDRCLSG 572

Query: 357 FYR-----------DPGRALSDR------------------------------RACRACD 375
            Y            DP   ++                                  C  C 
Sbjct: 573 AYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECK 632

Query: 376 CHPVGAAGKT--CNQTTGQCPCKDGVTGLTCNRCAPGF 411
           CH  G    T  C Q  G C CK  V G +C+ C  G+
Sbjct: 633 CHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGY 670



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 31/113 (27%), Positives = 42/113 (37%), Gaps = 36/113 (31%)

Query: 274  CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
            C C+    G  C RC   +   P           C+ C+CN                G  
Sbjct: 1378 CRCKPRITGRQCDRCASGFYRFP----------ECVPCNCNR--------------DGTE 1413

Query: 334  SG------GVCLNCRHNTAGRHCHYCREG-FYRDPGRALSDRRACRACDCHPV 379
             G      G CL C+ N  G  C+ CREG F+ DP    ++ + C +C C  V
Sbjct: 1414 PGVCDPGTGACL-CKENVEGTECNVCREGSFHLDP----ANLKGCTSCFCFGV 1461


>gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]
          Length = 3277

 Score =  195 bits (496), Expect = 8e-50
 Identities = 132/419 (31%), Positives = 198/419 (47%), Gaps = 48/419 (11%)

Query: 67  CDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPL--NVTLTVPLGKAFELVFVSLRF 124
           C++ DPR+AH P      G   S   W+S  L        V LT+ LG+ F + ++ ++F
Sbjct: 105 CNSEDPRKAH-PVTNAIDG---SERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKF 160

Query: 125 CSAP-PASVALLKSQDHGRSWAPLGFFSSH---CDLDYGRLPAPANGPAGPGPEALCFPA 180
            ++P P    L +S D G +++P  +F+     C  ++GR    AN       + LC   
Sbjct: 161 ANSPRPDLWVLERSVDFGSTYSPWQYFAHSKVDCLKEFGR---EANMAVTRDDDVLCVTE 217

Query: 181 -PLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPST------AGDP 233
                P  +G +  S+ +  P   +   S  L+++  AT++R+   R +T      +   
Sbjct: 218 YSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQ 277

Query: 234 RDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLI-CDCRHGTEGPDCGRCKPFY 292
           RD      Y Y+  D+ +GG+C CNGHA  C ++    L  C+C+H T G  C RC   Y
Sbjct: 278 RDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGY 337

Query: 293 CDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR-------RSGGVCLNCRHNT 345
             R W+ A   +SH C AC+C+GHA  C ++ ++ R             GGVC+NC+HNT
Sbjct: 338 NQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNT 397

Query: 346 AGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCN 405
           AG +C  C +G+YR  G  +     C  C C P  A G  C Q +G+C CK    G  C 
Sbjct: 398 AGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADG--CEQGSGRCHCKPNFHGDNCE 455

Query: 406 RCAPGFQQ----SRSPVAPCVKTP---------IPGPTEDSSPVQPQDCDSH----CKP 447
           +CA G+       R P+ P V TP         I G   +   V P+ CD+H    C+P
Sbjct: 456 KCAIGYYNFPFCLRIPIFP-VSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRP 513



 Score =  103 bits (257), Expect = 4e-22
 Identities = 67/192 (34%), Positives = 85/192 (44%), Gaps = 41/192 (21%)

Query: 273  ICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332
            IC C     G  C  C P Y        T R    C+ C+CNGH+ +C+           
Sbjct: 1653 ICACPPAYAGDSCQGCSPGYYRDHKGLYTGR----CVPCNCNGHSNQCQ----------- 1697

Query: 333  RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVG--AAGKTCNQTT 390
               G+C+NC+HNTAG HC  C+EG+Y   G A+    +CRAC C      A G   N   
Sbjct: 1698 DGSGICVNCQHNTAGEHCERCQEGYY---GNAV--HGSCRACPCPHTNSFATGCVVNGGD 1752

Query: 391  GQCPCKDGVTGLTCNRCAPGF----QQSRSPVAPCVKT---------PIPG-----PTED 432
             +C CK G TG  C RCAPG+    Q+      PC            P+ G       +D
Sbjct: 1753 VRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKD 1812

Query: 433  SSPVQP-QDCDS 443
            SSP +   DCDS
Sbjct: 1813 SSPAEECDDCDS 1824



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 53/163 (32%), Positives = 68/163 (41%), Gaps = 23/163 (14%)

Query: 255 CKCNG-HASRCLLDTQGHLICDCRHGTEGPDCGRCK------PFYCDRPWQRATARESHA 307
           C C+  HA  C    QG   C C+    G +C +C       PF    P    +   S  
Sbjct: 426 CSCDPEHADGC---EQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSED 482

Query: 308 CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSD 367
            +A    G  + C  N+E        + G CL CR    G  C  CR GFY  P      
Sbjct: 483 PVA----GDIKGCDCNLEGVLPEICDAHGRCL-CRPGVEGPRCDTCRSGFYSFP------ 531

Query: 368 RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
              C+AC C  +G+    C+  TGQC C+ GVTG  C+RC  G
Sbjct: 532 --ICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSG 572



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 45/159 (28%), Positives = 64/159 (40%), Gaps = 30/159 (18%)

Query: 257 CNGHASRCLLDTQGHL-----ICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLAC 311
           C G +S C  D  G +      C C+   EGP C RCK  Y    W       S  C  C
Sbjct: 579 CQGSSSAC--DPAGTINSNLGYCQCKLHVEGPTCSRCKLLY----WNLDKENPS-GCSEC 631

Query: 312 SCNGHARRCRFNMELYRLSG----RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSD 367
            C+          +   +SG    R+  G C +C+ +  G  C  C +G++       S+
Sbjct: 632 KCH----------KAGTVSGTGECRQGDGDC-HCKSHVGGDSCDTCEDGYF---ALEKSN 677

Query: 368 RRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNR 406
              C+ C C   GA    C+  +G C C++ V G  C R
Sbjct: 678 YFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQR 716



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 55/198 (27%), Positives = 77/198 (38%), Gaps = 30/198 (15%)

Query: 217  ATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRC---KCNGHASRCLLDTQGHLI 273
            A  V +    P+ AGD    +   P  Y        GRC    CNGH+++C     G  I
Sbjct: 1648 ALAVEICACPPAYAGD--SCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQC---QDGSGI 1702

Query: 274  C-DCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332
            C +C+H T G  C RC+  Y    +  A      AC     N  A  C  N         
Sbjct: 1703 CVNCQHNTAGEHCERCQEGY----YGNAVHGSCRACPCPHTNSFATGCVVN--------- 1749

Query: 333  RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQ 392
              G V  +C+    G  C  C  G++ +P +      +C+ C C+  G  G +C+  TG 
Sbjct: 1750 -GGDVRCSCKAGYTGTQCERCAPGYFGNPQKF---GGSCQPCSCNSNGQLG-SCHPLTGD 1804

Query: 393  C---PCKDGVTGLTCNRC 407
            C     KD      C+ C
Sbjct: 1805 CINQEPKDSSPAEECDDC 1822



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 51/176 (28%), Positives = 66/176 (37%), Gaps = 33/176 (18%)

Query: 252  GGRCKC--NGHASRCLLDTQGHL------ICDCRHGTEGPDCGRCK-PFYCDRPWQRATA 302
            GG+C C  N    +C     GH        C C         G+C+ P    RP  +   
Sbjct: 1282 GGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCRCPPRTVRP--QCEV 1339

Query: 303  RESHA--------CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCR 354
             E+H+        C  C+C+      R  +E       R  G C  C+    GR C  C 
Sbjct: 1340 CETHSFSFHPMAGCEGCNCSR-----RGTIEAAMPECDRDSGQC-RCKPRITGRQCDRCA 1393

Query: 355  EGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG 410
             GFYR P         C  C+C+  G     C+  TG C CK+ V G  CN C  G
Sbjct: 1394 SGFYRFP--------ECVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCREG 1441



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 54/186 (29%), Positives = 66/186 (35%), Gaps = 32/186 (17%)

Query: 248  DLQVGGRCKCNGHASRCLLDTQGHLICDCRH-GTEGPDCGR------CKPFYCDRPWQR- 299
            D Q   R   N   S      +G L C+C   G  GP C        C+P    R   R 
Sbjct: 1240 DPQTASRFCKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRC 1299

Query: 300  ATARESHA-CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY 358
            AT       C  CSC    R C               G C  C   T    C  C    +
Sbjct: 1300 ATGHYGFPRCKPCSCG--RRLCE-----------EMTGQC-RCPPRTVRPQCEVCETHSF 1345

Query: 359  RDPGRALSDRRACRACDCHPVG---AAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSR 415
                 +      C  C+C   G   AA   C++ +GQC CK  +TG  C+RCA GF +  
Sbjct: 1346 -----SFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFP 1400

Query: 416  SPVAPC 421
              V PC
Sbjct: 1401 ECV-PC 1405



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 51/218 (23%), Positives = 70/218 (32%), Gaps = 64/218 (29%)

Query: 239 VVPYSYAATDLQVGGRCK-CNGHASRCLLDT-QGHLICDCRHGTEGPDCGRCKPFYCDRP 296
           + P S  +++  V G  K C+ +    L +    H  C CR G EGP C  C+  +   P
Sbjct: 472 IFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFP 531

Query: 297 WQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREG 356
                      C AC C+         +  Y++      G C  CR    G+ C  C  G
Sbjct: 532 ----------ICQACWCSA--------LGSYQMPCSSVTGQC-ECRPGVTGQRCDRCLSG 572

Query: 357 FYR-----------DPGRALSDR------------------------------RACRACD 375
            Y            DP   ++                                  C  C 
Sbjct: 573 AYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECK 632

Query: 376 CHPVGAAGKT--CNQTTGQCPCKDGVTGLTCNRCAPGF 411
           CH  G    T  C Q  G C CK  V G +C+ C  G+
Sbjct: 633 CHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGY 670



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 31/113 (27%), Positives = 42/113 (37%), Gaps = 36/113 (31%)

Query: 274  CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
            C C+    G  C RC   +   P           C+ C+CN                G  
Sbjct: 1378 CRCKPRITGRQCDRCASGFYRFP----------ECVPCNCNR--------------DGTE 1413

Query: 334  SG------GVCLNCRHNTAGRHCHYCREG-FYRDPGRALSDRRACRACDCHPV 379
             G      G CL C+ N  G  C+ CREG F+ DP    ++ + C +C C  V
Sbjct: 1414 PGVCDPGTGACL-CKENVEGTECNVCREGSFHLDP----ANLKGCTSCFCFGV 1461


>gi|190014607 netrin G2 [Homo sapiens]
          Length = 530

 Score =  194 bits (494), Expect = 1e-49
 Identities = 123/393 (31%), Positives = 186/393 (47%), Gaps = 50/393 (12%)

Query: 58  TCGRPATR------------ACDASDPRRAHSPALLTSPGGTASPLCWRSESLPR--APL 103
           TCG P  R             CDAS+P  AH P L+           W+S +  R  +PL
Sbjct: 60  TCGDPPERFCSHENPYLCSNECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRYPSPL 119

Query: 104 NVTLTVPLGKAFELVF-VSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLP 162
              +T+   K  EL   V + F    P  + L KS D+GR+W P  F++  C   +G   
Sbjct: 120 EANITLSWNKTVELTDDVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSA 179

Query: 163 APANGPAGPGPEALCFPAPLAQPDGSGL---LAFSMQDS----SPPGL--------DLDS 207
             A   +      +      ++  GS     + F ++D     + P L         L+S
Sbjct: 180 RRARDMSSSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRNMDNLYTRLES 239

Query: 208 SPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLD 267
           +  L+++ T TD+R+ L RP+  G     E +  Y YA ++++V GRCKCN HA+ C + 
Sbjct: 240 AKGLKEFFTLTDLRMRLLRPALGGTYVQRENLYKYFYAISNIEVIGRCKCNLHANLCSM- 298

Query: 268 TQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRAT-----ARESHACLA------CSCNGH 316
            +G L C+C H T GPDCG+CK  +  R W+  +         +AC        C C GH
Sbjct: 299 REGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNACATAGSFGNCECYGH 358

Query: 317 ARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDC 376
           + RC +   L  ++       C++C+HNT G+HC +CR G+YR+    L D   C  C+C
Sbjct: 359 SNRCSYIDFLNVVT-------CVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNC 411

Query: 377 HPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAP 409
           + +G+    CN+ TG C C++G  G  C+ C P
Sbjct: 412 NQIGSVHDRCNE-TGFCECREGAAGPKCDDCLP 443


>gi|21264602 laminin alpha 5 [Homo sapiens]
          Length = 3695

 Score =  193 bits (490), Expect = 4e-49
 Identities = 142/482 (29%), Positives = 205/482 (42%), Gaps = 77/482 (15%)

Query: 10  LTAGTLFAALSPGPPAP----------ADPCHDEGGAPRGCVPGLVNAALGREVLASSTC 59
           L AG+      P  PAP          A    +E G      P   N A G  + AS+TC
Sbjct: 5   LCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATC 64

Query: 60  GRPATRA----------------------------------CDASDPRRAHSPALLTSPG 85
           G  A                                     C A++  +AH PA     G
Sbjct: 65  GEEAPARGSPRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICTAANSNKAH-PASNAIDG 123

Query: 86  GTASPLCWRSESLPRAPL--NVTLTVPLGKAFELVFVSLRFCSAP-PASVALLKSQDHGR 142
              +   W+S  L R      V +T+ LG+ F + +V ++F ++P P    L +S D GR
Sbjct: 124 ---TERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGR 180

Query: 143 SWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPA-PLAQPDGSGLLAFSMQDSSPP 201
           ++ P  FF+S       R              A+C        P  +G +  S+ +  P 
Sbjct: 181 TYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPG 240

Query: 202 GLDLDSSPVLQDWVTATDVRVVLTRPST------AGDPRDMEAVVPYSYAATDLQVGGRC 255
            ++   SP+L+++  AT+VR+   R +T          RD      Y Y+  D+ +GGRC
Sbjct: 241 AMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALRDPTVTRRYYYSIKDISIGGRC 300

Query: 256 KCNGHASRCLLDTQG-----HLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLA 310
            C+GHA  C  D +       L C C+H T G  C RC P +  +PW+ ATA  ++ C +
Sbjct: 301 VCHGHADAC--DAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQS 358

Query: 311 CSCNGHARRCRFNMELYRLSGRRS-------GGVCLNCRHNTAGRHCHYCREGFYRDPGR 363
           C+C GHA  C ++ E+ R    +S       GGVC++C+H+T G +C  C  GFYR P  
Sbjct: 359 CNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNH 418

Query: 364 ALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVK 423
            L     CR C+C      G TC   TG+C C+   +G  C+ CA GF    S    C  
Sbjct: 419 PLDSPHVCRRCNCESDFTDG-TCEDLTGRCYCRPNFSGERCDVCAEGFTGFPS----CYP 473

Query: 424 TP 425
           TP
Sbjct: 474 TP 475



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 61/192 (31%), Positives = 77/192 (40%), Gaps = 23/192 (11%)

Query: 258  NGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHA 317
            N  A  C+L   G   C C+ G  G  C RC P +   P    +     +C  C C+G+ 
Sbjct: 1922 NNFAEGCVL-RGGRTQCLCKPGYAGASCERCAPGFFGNPLVLGS-----SCQPCDCSGNG 1975

Query: 318  RRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCH 377
                   +   L+     G C  C  +T G  C  C  GFY   G AL     C  CDC 
Sbjct: 1976 DPNLLFSDCDPLT-----GACRGCLRHTTGPRCEICAPGFY---GNALLPGN-CTRCDCT 2026

Query: 378  PVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF--QQSRSPVAPCVKTPIPGPTEDSSP 435
            P G   + C+  +G C CK GVTG  C+RC  G           PC      GP  + S 
Sbjct: 2027 PCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGCRPCA----CGPAAEGSE 2080

Query: 436  VQPQDCDSHCKP 447
              PQ    HC+P
Sbjct: 2081 CHPQSGQCHCRP 2092



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 64/193 (33%), Positives = 79/193 (40%), Gaps = 34/193 (17%)

Query: 273  ICDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSG 331
            +C C     G  C  C P FY D             C+ C C+GH+ RC        L G
Sbjct: 1830 LCLCPASYRGDSCQECAPGFYRD-----VKGLFLGRCVPCQCHGHSDRC--------LPG 1876

Query: 332  RRSGGVCLNCRHNTAGRHCHYCREGFY--RDPGRALSDRRACRACDCH---PVGAAGKTC 386
                GVC++C+HNT G HC  C+ GF   RD   A      C +C C    P     + C
Sbjct: 1877 ---SGVCVDCQHNTEGAHCERCQAGFVSSRDDPSA-----PCVSCPCPLSVPSNNFAEGC 1928

Query: 387  NQTTG--QCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSH 444
                G  QC CK G  G +C RCAPGF  +     P V      P + S    P    S 
Sbjct: 1929 VLRGGRTQCLCKPGYAGASCERCAPGFFGN-----PLVLGSSCQPCDCSGNGDPNLLFSD 1983

Query: 445  CKPARGSYRISLK 457
            C P  G+ R  L+
Sbjct: 1984 CDPLTGACRGCLR 1996



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 62/203 (30%), Positives = 78/203 (38%), Gaps = 44/203 (21%)

Query: 252  GGRCKCNGHA-----SRCLLDTQGH----------LICD-------CRHGTEGPDCGRCK 289
            GG+C C+ H      SRC     G            +CD       C   T  PDC  C+
Sbjct: 1454 GGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQ 1513

Query: 290  PFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRH 349
            P       Q         C  C+C+G   +     EL   +     G C  CR N  GR 
Sbjct: 1514 P-------QTFGCHPLVGCEECNCSGPGIQ-----ELTDPTCDTDSGQC-KCRPNVTGRR 1560

Query: 350  CHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAP 409
            C  C  GF+  P         CR CDCH  G A   C+  TGQC CK+ V G  C++C+ 
Sbjct: 1561 CDTCSPGFHGYP--------RCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSL 1612

Query: 410  G-FQQSRSPVAPCVKTPIPGPTE 431
            G F    +    C +    G TE
Sbjct: 1613 GTFSLDAANPKGCTRCFCFGATE 1635



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 57/170 (33%), Positives = 67/170 (39%), Gaps = 36/170 (21%)

Query: 255 CKCNGHA---SRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLAC 311
           C+C+       RC  DT     C CR G EG  C RC P Y   P           C  C
Sbjct: 541 CQCSSPGVADDRCDPDTGQ---CRCRVGFEGATCDRCAPGYFHFP----------LCQLC 587

Query: 312 SCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRAC 371
            C+                G    G CL C+   AG HC  CR G++  P         C
Sbjct: 588 GCSPAGTLPE---------GCDEAGRCL-CQPEFAGPHCDRCRPGYHGFPN--------C 629

Query: 372 RACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPC 421
           +AC C P GA  + C    G C C+ G TG  C  C+PGF    S V PC
Sbjct: 630 QACTCDPRGALDQLCG-AGGLCRCRPGYTGTACQECSPGFHGFPSCV-PC 677



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 71/275 (25%), Positives = 89/275 (32%), Gaps = 87/275 (31%)

Query: 255 CKCNGHASRCLLDT---------------QGHLIC-DCRHGTEGPDCGRCKP-FY----- 292
           C C GHA+ C  D                QG  +C DC+H T G +C RC P FY     
Sbjct: 359 CNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNH 418

Query: 293 ------------CDRPWQRATARESHACLACSCNGHARRCRFNMELYR------------ 328
                       C+  +   T  +      C  N    RC    E +             
Sbjct: 419 PLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSS 478

Query: 329 -------------------LSGRRSG--------GVCLNCRHNTAGRHCHYCREGFYRDP 361
                               +G +          G CL C+ N  G HC  C  GFY  P
Sbjct: 479 NDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCL-CKPNFQGTHCELCAPGFY-GP 536

Query: 362 GRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQ----SRSP 417
           G        C+ C C   G A   C+  TGQC C+ G  G TC+RCAPG+          
Sbjct: 537 G--------CQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCG 588

Query: 418 VAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARGSY 452
            +P    P           QP+    HC   R  Y
Sbjct: 589 CSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGY 623



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 45/137 (32%), Positives = 59/137 (43%), Gaps = 28/137 (20%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
           C C+    GP C RC+P Y   P           C AC+C+           L +L G  
Sbjct: 605 CLCQPEFAGPHCDRCRPGYHGFP----------NCQACTCDPRGA-------LDQLCG-- 645

Query: 334 SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQC 393
           +GG+C  CR    G  C  C  GF+  P        +C  C C   G+    C+  +GQC
Sbjct: 646 AGGLC-RCRPGYTGTACQECSPGFHGFP--------SCVPCHCSAEGSLHAACDPRSGQC 696

Query: 394 PCKDGVTGLTCNRCAPG 410
            C+  VTGL C+ C PG
Sbjct: 697 SCRPRVTGLRCDTCVPG 713



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 44/140 (31%), Positives = 61/140 (43%), Gaps = 25/140 (17%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN-----GHARRCRFNMELYR 328
           C CR   EGP C RCKP +    W  + +     C  CSC+     G    C+       
Sbjct: 744 CMCRAHVEGPSCDRCKPGF----WGLSPSNPE-GCTRCSCDLRGTLGGVAECQ------- 791

Query: 329 LSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQ 388
                  G C  C+ +  G+ C  C++GF+   G   +D   CR+C C   GA G++C  
Sbjct: 792 ----PGTGQCF-CKPHVCGQACASCKDGFF---GLDQADYFGCRSCRCDIGGALGQSCEP 843

Query: 389 TTGQCPCKDGVTGLTCNRCA 408
            TG C C+    G TC+  A
Sbjct: 844 RTGVCRCRPNTQGPTCSEPA 863



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 51/204 (25%), Positives = 67/204 (32%), Gaps = 52/204 (25%)

Query: 254 RCKCNGHA----SRCLLDTQGHL--------ICDCRHGTEGPDCGRCKPFYCDRPWQRAT 301
           RC+   H       C  D +G L        +C CR G  G  C  C P +   P     
Sbjct: 618 RCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPC 677

Query: 302 ARESHACLACSCNGHARRCRFNMELYRLSGRR--------------SGGVC--------- 338
              +   L  +C+  + +C       R++G R                G C         
Sbjct: 678 HCSAEGSLHAACDPRSGQCSCRP---RVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVD 734

Query: 339 ---------LNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKT--CN 387
                      CR +  G  C  C+ GF+   G + S+   C  C C   G  G    C 
Sbjct: 735 PALPEAQVPCMCRAHVEGPSCDRCKPGFW---GLSPSNPEGCTRCSCDLRGTLGGVAECQ 791

Query: 388 QTTGQCPCKDGVTGLTCNRCAPGF 411
             TGQC CK  V G  C  C  GF
Sbjct: 792 PGTGQCFCKPHVCGQACASCKDGF 815



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 26/57 (45%), Positives = 30/57 (52%), Gaps = 2/57 (3%)

Query: 357  FYRDPGRALS--DRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
            F R+   +LS       R C CH VGA G TC    GQCPC   V G  C+RCA G+
Sbjct: 1419 FCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGY 1475



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 16/50 (32%), Positives = 19/50 (38%), Gaps = 9/50 (18%)

Query: 274  CDCRHGTEGPDCGRCK--PFYCDRPWQRATARESHACLACSCNGHARRCR 321
            C C+   +GP C +C    F  D       A     C  C C G   RCR
Sbjct: 1596 CYCKENVQGPKCDQCSLGTFSLD-------AANPKGCTRCFCFGATERCR 1638


>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
          Length = 3075

 Score =  190 bits (483), Expect = 3e-48
 Identities = 141/486 (29%), Positives = 219/486 (45%), Gaps = 76/486 (15%)

Query: 38  RGCVPGLVNAALGREVLASSTCGR--------------------PATRACD--ASDPRRA 75
           RG  P ++N A    +  ++TCG                     P  R CD  +++PR  
Sbjct: 20  RGLFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRPVRNPQCRICDGNSANPRER 79

Query: 76  HSPALLTSPGGTASPLCWRSESLP--RAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVA 133
           H   +  +  GT +   W+S S+   R    VT+T+ L + F++ +V ++  +AP     
Sbjct: 80  HP--ISHAIDGTNN--WWQSPSIQNGREYHWVTITLDLRQVFQVAYVIIKAANAPRPGNW 135

Query: 134 LLKSQDHGRSWAPLGFFS---SHCDLDYGRLPAPANGPAGPGPEALC--FPAPLAQPDGS 188
           +L+    G +++P  +++   S C   Y   P           E +C  + + L  P   
Sbjct: 136 ILERSLDGTTFSPWQYYAVSDSECLSRYNITPRRGPPTYRADDEVICTSYYSRLV-PLEH 194

Query: 189 GLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAG---------DPRDMEAV 239
           G +  S+ +  P   DL  SP L ++ +A  +R+ L R  T           +P++++ +
Sbjct: 195 GEIHTSLINGRPSADDL--SPKLLEFTSARYIRLRLQRIRTLNADLMTLSHREPKELDPI 252

Query: 240 VP--YSYAATDLQVGGRCKCNGHASRCLLD-TQGHLICDCRHGTEGPDCGRCKPFYCDRP 296
           V   Y Y+  D+ VGG C C GHAS C  D T   L C C H T G  C RC P Y  +P
Sbjct: 253 VTRRYYYSIKDISVGGMCICYGHASSCPWDETTKKLQCQCEHNTCGESCNRCCPGYHQQP 312

Query: 297 WQRATARESHACLACSCNGHARRCRFNMELYR------LSGR-RSGGVCLNCRHNTAGRH 349
           W+  T    + C AC+C+  A+ C ++  + +       +G+ R GGVC+NC  NT G +
Sbjct: 313 WRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGIN 372

Query: 350 CHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTC-----------NQTTGQCPCKDG 398
           C  C +G+YR    +  +   CR C+C PVG+    C            +  GQCPCK+G
Sbjct: 373 CETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEG 432

Query: 399 VTGLTCNRCAPGFQQ-------SRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARGS 451
            TG  C+RC  G++          +PV      P  GP      V+ + CD  CKP  G 
Sbjct: 433 YTGEKCDRCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKACD-RCKP--GF 489

Query: 452 YRISLK 457
           Y +  K
Sbjct: 490 YNLKEK 495



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 61/195 (31%), Positives = 80/195 (41%), Gaps = 26/195 (13%)

Query: 258 NGHASRCLLDTQGHLICD-CRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGH 316
           N  +  C L+    ++CD C  G  G  C RC   Y   P          +C+ C C+G+
Sbjct: 800 NNFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNP-----TVPGESCVPCDCSGN 854

Query: 317 ARRCRFNMELYRLSGRRSG--GVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
                        +G      G CL C  NT G HC  C +GFY D   A    + CRAC
Sbjct: 855 VDPSE--------AGHCDSVTGECLKCLGNTDGAHCERCADGFYGDAVTA----KNCRAC 902

Query: 375 DCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQ--QSRSPVAPCVKTPIPGPTED 432
           +CH  G+    C+  TG C CK  VTG  C++C  G+    S     PC    + G   D
Sbjct: 903 ECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGCRPC-NCSVAGSVSD 961

Query: 433 SSPVQPQDCDSHCKP 447
               + Q    HC P
Sbjct: 962 GCTDEGQ---CHCVP 973



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 55/189 (29%), Positives = 73/189 (38%), Gaps = 25/189 (13%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
           C+C  G  G  C  C   Y    ++         C  C C+GHA  C  +          
Sbjct: 709 CECPQGYTGTSCESCLSGY----YRVDGILFGGICQPCECHGHAAECNVH---------- 754

Query: 334 SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQC 393
             GVC+ C HNT G HC  C  GFY +P R       C+ C C P+  A    + T   C
Sbjct: 755 --GVCIACAHNTTGVHCEQCLPGFYGEPSRGTPG--DCQPCAC-PLTIASNNFSPT---C 806

Query: 394 PCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARGSYR 453
              DG   + C+ CAPG+  S +    C       PT       P DC  +  P+   + 
Sbjct: 807 HLNDG-DEVVCDWCAPGY--SGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHC 863

Query: 454 ISLKKFCKK 462
            S+   C K
Sbjct: 864 DSVTGECLK 872



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 47/155 (30%), Positives = 68/155 (43%), Gaps = 13/155 (8%)

Query: 255  CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN 314
            C CN H+  C  D       +C   T G  C  C   Y    + + T   S  C  C+C 
Sbjct: 1403 CSCNNHSDTC--DPNTGKCLNCGDNTAGDHCDVCTSGY----YGKVTGSASD-CALCACP 1455

Query: 315  GHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
             H+    F+     L G      C  C     G+HC  C   +Y +P    +   +C+ C
Sbjct: 1456 -HSPPASFSPTCV-LEGDHDFR-CDACLLGYEGKHCERCSSSYYGNPQ---TPGGSCQKC 1509

Query: 375  DCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAP 409
            DC+P G+    C++T+GQC C+ G +GL C+ C P
Sbjct: 1510 DCNPHGSVHGDCDRTSGQCVCRLGASGLRCDECEP 1544



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 41/149 (27%), Positives = 56/149 (37%), Gaps = 28/149 (18%)

Query: 274  CDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332
            C C  G  G  C RC   FY         A +  +C  C C      C            
Sbjct: 969  CHCVPGVAGKRCDRCAHGFY---------AYQDGSCTPCDCPHTQNTCD----------- 1008

Query: 333  RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQ 392
               G C+ C  +T G  C  C +G +            C+AC+C  VG+    C+  TG 
Sbjct: 1009 PETGECV-CPPHTQGVKCEECEDGHWGYDAEV-----GCQACNCSLVGSTHHRCDVVTGH 1062

Query: 393  CPCKDGVTGLTCNRCAPGFQQSRSPVAPC 421
            C CK    G  C++C+ G++     V PC
Sbjct: 1063 CQCKSKFGGRACDQCSLGYRDFPDCV-PC 1090



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 46/161 (28%), Positives = 54/161 (33%), Gaps = 47/161 (29%)

Query: 274  CDCRH--GTEGPDCGRCKPFYCDRPWQRATARESH----------ACLACSCN---GHAR 318
            CDC H   T  P+ G C    C    Q     E             C AC+C+       
Sbjct: 998  CDCPHTQNTCDPETGEC---VCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVGSTHH 1054

Query: 319  RCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHP 378
            RC               G C  C+    GR C  C  G+   P         C  CDC  
Sbjct: 1055 RCDVVT-----------GHC-QCKSKFGGRACDQCSLGYRDFPD--------CVPCDCDL 1094

Query: 379  VGAAGKTCN---------QTTGQCPCKDGVTGLTCNRCAPG 410
             G +G  CN         + TG CPCK+ V G  CN C  G
Sbjct: 1095 RGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREG 1135



 Score = 37.7 bits (86), Expect = 0.029
 Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 8/61 (13%)

Query: 393  CPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSH---CKPAR 449
            C C  G  G +C  CAPG+ + + P          GP    +P  P  C++H   C P  
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAG-----SDRGPRPLVAPCVPCSCNNHSDTCDPNT 1416

Query: 450  G 450
            G
Sbjct: 1417 G 1417



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 37/134 (27%), Positives = 50/134 (37%), Gaps = 22/134 (16%)

Query: 248  DLQVGGR-CKCNGHAS---RCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATAR 303
            D +VG + C C+   S   RC + T GH  C C+    G  C +C   Y D P       
Sbjct: 1036 DAEVGCQACNCSLVGSTHHRCDVVT-GH--CQCKSKFGGRACDQCSLGYRDFP------- 1085

Query: 304  ESHACLACSCNGHARRC-RFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPG 362
                C+ C C+         N+E          G C  C+ N  G  C+ CREG +    
Sbjct: 1086 ---DCVPCDCDLRGTSGDACNLEQGLCGCVEETGAC-PCKENVFGPQCNECREGTF---A 1138

Query: 363  RALSDRRACRACDC 376
                +   C  C C
Sbjct: 1139 LRADNPLGCSPCFC 1152


>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
           sapiens]
          Length = 3118

 Score =  167 bits (424), Expect = 2e-41
 Identities = 130/473 (27%), Positives = 204/473 (43%), Gaps = 72/473 (15%)

Query: 38  RGCVPGLVNAALGREVLASSTCGR--------------------PATRACD--ASDPRRA 75
           RG  P ++N A    +  ++TCG                     P  R C+  +S+P + 
Sbjct: 37  RGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQR 96

Query: 76  HSPALLTSPGGTASPLCWRSESLPRAPLN--VTLTVPLGKAFELVFVSLRFCSAP-PASV 132
           H          T     W+S S+        VT+T+ L + F++ +V ++  ++P P + 
Sbjct: 97  HPITNAIDGKNT----WWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNW 152

Query: 133 ALLKSQD--HGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALC--FPAPLAQPDGS 188
            L +S D    + W       + C   Y   P           E +C  F + +  P  +
Sbjct: 153 ILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKI-HPLEN 211

Query: 189 GLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAG---------DPRDMEAV 239
           G +  S+ +  P   D   SP L ++ +A  +R+   R  T           DPR+++ +
Sbjct: 212 GEIHISLINGRPSADD--PSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPI 269

Query: 240 VP--YSYAATDLQVGGRCKCNGHASRCLLDTQGHLI-CDCRHGTEGPDCGRCKPFYCDRP 296
           V   Y Y+  D+ VGG C C GHA  C LD   +   C+C H T G  C +C P +  +P
Sbjct: 270 VTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKP 329

Query: 297 WQRATARESHACLACSCNGHARRCRFNMELYR------LSGRR-SGGVCLNCRHNTAGRH 349
           W+  T      C AC+C+G A  C ++  + R      + G+   GGVC+NC  NTAG +
Sbjct: 330 WRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGIN 389

Query: 350 CHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTC---------NQTTGQCPCKDGVT 400
           C  C +GF+R  G + +  R C+ C C P+G+  + C             G C CK G  
Sbjct: 390 CETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449

Query: 401 GLTCNRCAPGFQQ-------SRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCK 446
           G++C+RCA G+         + S +    + P  GP      V+  DC S CK
Sbjct: 450 GVSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDC-SRCK 501



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/169 (31%), Positives = 76/169 (44%), Gaps = 22/169 (13%)

Query: 258 NGHASRCLLDTQGHLICD-CRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGH 316
           N  +  C LD    LICD C  G  GP C RC   Y  +P     +    +C  C CN  
Sbjct: 816 NNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQP-----SVPGGSCQPCQCND- 869

Query: 317 ARRCRFNMELYRLSGRRSG--GVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
                 N++ + + G      G CL C+  T GR+C  C +G++ D      D + C+ C
Sbjct: 870 ------NLD-FSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDA----VDAKNCQPC 918

Query: 375 DCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF--QQSRSPVAPC 421
            C+  G+  + C+  TGQC C+  V G  C++C  G    QS     PC
Sbjct: 919 RCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPC 967



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/184 (29%), Positives = 77/184 (41%), Gaps = 28/184 (15%)

Query: 237  EAVVPYSYAATDLQVGGR-----------CKCNGHASRCLLDTQGHLICDCRHGTEGPDC 285
            EA +P  Y     Q GGR           C+CNGH+S C  D +  +  +C+H T G  C
Sbjct: 1392 EACLPGFYRLRS-QPGGRTPGPTLGTCVPCQCNGHSSLC--DPETSICQNCQHHTAGDFC 1448

Query: 286  GRCKPFYCDRPWQRATARESHAC-LACSCNGHARRC-RFNMELYRLSGRRSGGVCLNCRH 343
             RC   Y           +  AC L  S N  +  C    ++ YR         C  C  
Sbjct: 1449 ERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYR---------CTACPR 1499

Query: 344  NTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLT 403
               G++C  C  G+   PG   +   +C+ C+C P G+    C+  TG C C+ G TG  
Sbjct: 1500 GYEGQYCERCAPGYTGSPG---NPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556

Query: 404  CNRC 407
            C+ C
Sbjct: 1557 CDGC 1560



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 45/151 (29%), Positives = 57/151 (37%), Gaps = 24/151 (15%)

Query: 274  CDCRHGTEGPDCGRCKP-FYCDR--PWQRATARESHACLACSCNGHARRCRFNMELYRLS 330
            CDC  G  G  C  C P FY  R  P  R        C+ C CNGH+  C          
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCD--------- 1430

Query: 331  GRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTT 390
                  +C NC+H+TAG  C  C  G+Y   G        C+ C C  + ++        
Sbjct: 1431 --PETSICQNCQHHTAGDFCERCALGYY---GIVKGLPNDCQQCACPLISSSNNFSPSCV 1485

Query: 391  GQ-------CPCKDGVTGLTCNRCAPGFQQS 414
             +         C  G  G  C RCAPG+  S
Sbjct: 1486 AEGLDDYRCTACPRGYEGQYCERCAPGYTGS 1516



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 49/188 (26%), Positives = 71/188 (37%), Gaps = 30/188 (15%)

Query: 255  CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN 314
            C CN   S+   D +    C C+ G  G  C RC   Y +         +   C AC C+
Sbjct: 967  CNCNSFGSKSF-DCEESGQCWCQPGVTGKKCDRCAHGYFNF--------QEGGCTACECS 1017

Query: 315  GHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
                 C               G C+ C  NT G  C  C    +   G +++    C+AC
Sbjct: 1018 HLGNNCD-----------PKTGRCI-CPPNTIGEKCSKCAPNTW---GHSITT--GCKAC 1060

Query: 375  DCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG-FQQSRSPVAPCVKTPIPGPTEDS 433
            +C  VG+    CN  TGQC C    +G  C  C+ G +   R  +  C    +PG    +
Sbjct: 1061 NCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCF---LPGTDATT 1117

Query: 434  SPVQPQDC 441
               + + C
Sbjct: 1118 CDSETKKC 1125



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 58/191 (30%), Positives = 72/191 (37%), Gaps = 38/191 (19%)

Query: 273 ICDCRHGTEGPDCGRCKPFYCDRPWQRATARE-SHACLACSCNGHARRCRFNMELYRLSG 331
           +C C  G  G  C  C P +     +R         C  C C GHA  C           
Sbjct: 723 VCQCPPGYTGSSCESCWPRH-----RRVNGTIFGGICEPCQCFGHAESCD---------- 767

Query: 332 RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCH---PVGAAGKTC-- 386
               G CLNC+ +T G +C  C  GFY +P +  S+   C+ C C    P      TC  
Sbjct: 768 -DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSE--DCQPCACPLNIPSNNFSPTCHL 824

Query: 387 NQTTGQC--PCKDGVTGLTCNRCAPG-FQQSRSPVAPCVKTPIPGPTEDSSPVQ-PQDCD 442
           +++ G     C  G TG  C RCA G F Q   P   C     P    D+     P  CD
Sbjct: 825 DRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQ----PCQCNDNLDFSIPGSCD 880

Query: 443 S------HCKP 447
           S       CKP
Sbjct: 881 SLSGSCLICKP 891



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 48/174 (27%), Positives = 61/174 (35%), Gaps = 38/174 (21%)

Query: 248  DLQVGG--RCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARES 305
            + Q GG   C+C+   + C   T     C C   T G  C +C P      W  +     
Sbjct: 1005 NFQEGGCTACECSHLGNNCDPKTGR---CICPPNTIGEKCSKCAP----NTWGHSITTGC 1057

Query: 306  HACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRAL 365
             AC   +      +C  N            G C NC    +G  C  C  G +  P    
Sbjct: 1058 KACNCSTVGSLDFQCNVNT-----------GQC-NCHPKFSGAKCTECSRGHWNYP---- 1101

Query: 366  SDRRACRACDCHPVGAAGKTCNQTT---------GQCPCKDGVTGLTCNRCAPG 410
                 C  CDC   G    TC+  T         GQC CK  V G+ C+RC PG
Sbjct: 1102 ----RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPG 1151



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 29/119 (24%), Positives = 43/119 (36%), Gaps = 24/119 (20%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
           C C+ G  G  C RC   Y   P           C AC+C+G   +          +   
Sbjct: 442 CHCKTGFGGVSCDRCARGYTGYP----------DCKACNCSGLGSK----------NEDP 481

Query: 334 SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQ 392
             G C+ C+ N  G  C  C+ GF+        + + C  C C  V    ++   T G+
Sbjct: 482 CFGPCI-CKENVEGGDCSRCKSGFF---NLQEDNWKGCDECFCSGVSNRCQSSYWTYGK 536



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 6/88 (6%)

Query: 392  QCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSS-PVQPQDCDSHCKPARG 450
            +C C  G +GL+C  C PGF + RS   P  +T  PGPT  +  P Q     S C P   
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRS--QPGGRT--PGPTLGTCVPCQCNGHSSLCDP-ET 1433

Query: 451  SYRISLKKFCKKDYAVQVAVGARGEARG 478
            S   + +     D+  + A+G  G  +G
Sbjct: 1434 SICQNCQHHTAGDFCERCALGYYGIVKG 1461



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 21/70 (30%), Positives = 27/70 (38%), Gaps = 18/70 (25%)

Query: 19  LSPGPPAPADPCH-------------DEGGAPRGCVPGLVNAALGREVLASSTCGR---- 61
           +SP  P P  PCH             DE  A RG  PG  +   G   ++   C R    
Sbjct: 403 VSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTG 462

Query: 62  -PATRACDAS 70
            P  +AC+ S
Sbjct: 463 YPDCKACNCS 472


>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
           sapiens]
          Length = 3122

 Score =  167 bits (424), Expect = 2e-41
 Identities = 130/473 (27%), Positives = 204/473 (43%), Gaps = 72/473 (15%)

Query: 38  RGCVPGLVNAALGREVLASSTCGR--------------------PATRACD--ASDPRRA 75
           RG  P ++N A    +  ++TCG                     P  R C+  +S+P + 
Sbjct: 37  RGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQR 96

Query: 76  HSPALLTSPGGTASPLCWRSESLPRAPLN--VTLTVPLGKAFELVFVSLRFCSAP-PASV 132
           H          T     W+S S+        VT+T+ L + F++ +V ++  ++P P + 
Sbjct: 97  HPITNAIDGKNT----WWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNW 152

Query: 133 ALLKSQD--HGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALC--FPAPLAQPDGS 188
            L +S D    + W       + C   Y   P           E +C  F + +  P  +
Sbjct: 153 ILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKI-HPLEN 211

Query: 189 GLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAG---------DPRDMEAV 239
           G +  S+ +  P   D   SP L ++ +A  +R+   R  T           DPR+++ +
Sbjct: 212 GEIHISLINGRPSADD--PSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPI 269

Query: 240 VP--YSYAATDLQVGGRCKCNGHASRCLLDTQGHLI-CDCRHGTEGPDCGRCKPFYCDRP 296
           V   Y Y+  D+ VGG C C GHA  C LD   +   C+C H T G  C +C P +  +P
Sbjct: 270 VTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKP 329

Query: 297 WQRATARESHACLACSCNGHARRCRFNMELYR------LSGRR-SGGVCLNCRHNTAGRH 349
           W+  T      C AC+C+G A  C ++  + R      + G+   GGVC+NC  NTAG +
Sbjct: 330 WRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGIN 389

Query: 350 CHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTC---------NQTTGQCPCKDGVT 400
           C  C +GF+R  G + +  R C+ C C P+G+  + C             G C CK G  
Sbjct: 390 CETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449

Query: 401 GLTCNRCAPGFQQ-------SRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCK 446
           G++C+RCA G+         + S +    + P  GP      V+  DC S CK
Sbjct: 450 GVSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDC-SRCK 501



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/169 (31%), Positives = 76/169 (44%), Gaps = 22/169 (13%)

Query: 258 NGHASRCLLDTQGHLICD-CRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGH 316
           N  +  C LD    LICD C  G  GP C RC   Y  +P     +    +C  C CN  
Sbjct: 816 NNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQP-----SVPGGSCQPCQCND- 869

Query: 317 ARRCRFNMELYRLSGRRSG--GVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
                 N++ + + G      G CL C+  T GR+C  C +G++ D      D + C+ C
Sbjct: 870 ------NLD-FSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDA----VDAKNCQPC 918

Query: 375 DCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF--QQSRSPVAPC 421
            C+  G+  + C+  TGQC C+  V G  C++C  G    QS     PC
Sbjct: 919 RCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPC 967



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/184 (29%), Positives = 77/184 (41%), Gaps = 28/184 (15%)

Query: 237  EAVVPYSYAATDLQVGGR-----------CKCNGHASRCLLDTQGHLICDCRHGTEGPDC 285
            EA +P  Y     Q GGR           C+CNGH+S C  D +  +  +C+H T G  C
Sbjct: 1392 EACLPGFYRLRS-QPGGRTPGPTLGTCVPCQCNGHSSLC--DPETSICQNCQHHTAGDFC 1448

Query: 286  GRCKPFYCDRPWQRATARESHAC-LACSCNGHARRC-RFNMELYRLSGRRSGGVCLNCRH 343
             RC   Y           +  AC L  S N  +  C    ++ YR         C  C  
Sbjct: 1449 ERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYR---------CTACPR 1499

Query: 344  NTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLT 403
               G++C  C  G+   PG   +   +C+ C+C P G+    C+  TG C C+ G TG  
Sbjct: 1500 GYEGQYCERCAPGYTGSPG---NPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556

Query: 404  CNRC 407
            C+ C
Sbjct: 1557 CDGC 1560



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 45/151 (29%), Positives = 57/151 (37%), Gaps = 24/151 (15%)

Query: 274  CDCRHGTEGPDCGRCKP-FYCDR--PWQRATARESHACLACSCNGHARRCRFNMELYRLS 330
            CDC  G  G  C  C P FY  R  P  R        C+ C CNGH+  C          
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCD--------- 1430

Query: 331  GRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTT 390
                  +C NC+H+TAG  C  C  G+Y   G        C+ C C  + ++        
Sbjct: 1431 --PETSICQNCQHHTAGDFCERCALGYY---GIVKGLPNDCQQCACPLISSSNNFSPSCV 1485

Query: 391  GQ-------CPCKDGVTGLTCNRCAPGFQQS 414
             +         C  G  G  C RCAPG+  S
Sbjct: 1486 AEGLDDYRCTACPRGYEGQYCERCAPGYTGS 1516



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 49/188 (26%), Positives = 71/188 (37%), Gaps = 30/188 (15%)

Query: 255  CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCN 314
            C CN   S+   D +    C C+ G  G  C RC   Y +         +   C AC C+
Sbjct: 967  CNCNSFGSKSF-DCEESGQCWCQPGVTGKKCDRCAHGYFNF--------QEGGCTACECS 1017

Query: 315  GHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRAC 374
                 C               G C+ C  NT G  C  C    +   G +++    C+AC
Sbjct: 1018 HLGNNCD-----------PKTGRCI-CPPNTIGEKCSKCAPNTW---GHSITT--GCKAC 1060

Query: 375  DCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPG-FQQSRSPVAPCVKTPIPGPTEDS 433
            +C  VG+    CN  TGQC C    +G  C  C+ G +   R  +  C    +PG    +
Sbjct: 1061 NCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCF---LPGTDATT 1117

Query: 434  SPVQPQDC 441
               + + C
Sbjct: 1118 CDSETKKC 1125



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 58/191 (30%), Positives = 72/191 (37%), Gaps = 38/191 (19%)

Query: 273 ICDCRHGTEGPDCGRCKPFYCDRPWQRATARE-SHACLACSCNGHARRCRFNMELYRLSG 331
           +C C  G  G  C  C P +     +R         C  C C GHA  C           
Sbjct: 723 VCQCPPGYTGSSCESCWPRH-----RRVNGTIFGGICEPCQCFGHAESCD---------- 767

Query: 332 RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCH---PVGAAGKTC-- 386
               G CLNC+ +T G +C  C  GFY +P +  S+   C+ C C    P      TC  
Sbjct: 768 -DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSE--DCQPCACPLNIPSNNFSPTCHL 824

Query: 387 NQTTGQC--PCKDGVTGLTCNRCAPG-FQQSRSPVAPCVKTPIPGPTEDSSPVQ-PQDCD 442
           +++ G     C  G TG  C RCA G F Q   P   C     P    D+     P  CD
Sbjct: 825 DRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQ----PCQCNDNLDFSIPGSCD 880

Query: 443 S------HCKP 447
           S       CKP
Sbjct: 881 SLSGSCLICKP 891



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 48/174 (27%), Positives = 61/174 (35%), Gaps = 38/174 (21%)

Query: 248  DLQVGG--RCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARES 305
            + Q GG   C+C+   + C   T     C C   T G  C +C P      W  +     
Sbjct: 1005 NFQEGGCTACECSHLGNNCDPKTGR---CICPPNTIGEKCSKCAP----NTWGHSITTGC 1057

Query: 306  HACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRAL 365
             AC   +      +C  N            G C NC    +G  C  C  G +  P    
Sbjct: 1058 KACNCSTVGSLDFQCNVNT-----------GQC-NCHPKFSGAKCTECSRGHWNYP---- 1101

Query: 366  SDRRACRACDCHPVGAAGKTCNQTT---------GQCPCKDGVTGLTCNRCAPG 410
                 C  CDC   G    TC+  T         GQC CK  V G+ C+RC PG
Sbjct: 1102 ----RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPG 1151



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 29/119 (24%), Positives = 43/119 (36%), Gaps = 24/119 (20%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
           C C+ G  G  C RC   Y   P           C AC+C+G   +          +   
Sbjct: 442 CHCKTGFGGVSCDRCARGYTGYP----------DCKACNCSGLGSK----------NEDP 481

Query: 334 SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQ 392
             G C+ C+ N  G  C  C+ GF+        + + C  C C  V    ++   T G+
Sbjct: 482 CFGPCI-CKENVEGGDCSRCKSGFF---NLQEDNWKGCDECFCSGVSNRCQSSYWTYGK 536



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 6/88 (6%)

Query: 392  QCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSS-PVQPQDCDSHCKPARG 450
            +C C  G +GL+C  C PGF + RS   P  +T  PGPT  +  P Q     S C P   
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRS--QPGGRT--PGPTLGTCVPCQCNGHSSLCDP-ET 1433

Query: 451  SYRISLKKFCKKDYAVQVAVGARGEARG 478
            S   + +     D+  + A+G  G  +G
Sbjct: 1434 SICQNCQHHTAGDFCERCALGYYGIVKG 1461



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 21/70 (30%), Positives = 27/70 (38%), Gaps = 18/70 (25%)

Query: 19  LSPGPPAPADPCH-------------DEGGAPRGCVPGLVNAALGREVLASSTCGR---- 61
           +SP  P P  PCH             DE  A RG  PG  +   G   ++   C R    
Sbjct: 403 VSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTG 462

Query: 62  -PATRACDAS 70
            P  +AC+ S
Sbjct: 463 YPDCKACNCS 472


>gi|219842266 usherin isoform B [Homo sapiens]
          Length = 5202

 Score =  163 bits (412), Expect = 5e-40
 Identities = 97/321 (30%), Positives = 151/321 (47%), Gaps = 23/321 (7%)

Query: 105 VTLTVPLGKA-FELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPA 163
           VT++V L    +++ ++ ++F S  P  + + + +++   W    +F+ +C    G    
Sbjct: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC----GAFGM 424

Query: 164 PANGPAGPGPEALCFPAPLAQPDGSGLLAFSMQDSSP---PGLD-LDSSPVLQDWVTATD 219
             NG         C       P   G + FS+    P   PG +   ++P LQ++V AT 
Sbjct: 425 KNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484

Query: 220 VRVVLTRPSTAGDPRDMEAVVPYS---YAATDLQVGGRCKCNGHASRCLLDTQGH-LICD 275
           +R         G     E  V      YA  ++ + GRC+C+GHA  C   +Q +  +C 
Sbjct: 485 IRFHFH-----GQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCS 539

Query: 276 CRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSG---R 332
               TEG  C RC P Y D+P+++     +  C  C CN H++ C +N+ +        R
Sbjct: 540 QESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFR 599

Query: 333 RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKT--CNQTT 390
             GGVC +C HNT GR+C  C++ F+R  G   S    C+ CDC  VG    +  C+Q  
Sbjct: 600 GGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIG 659

Query: 391 GQCPCKDGVTGLTCNRCAPGF 411
           GQC CK  V+G  CN+C  GF
Sbjct: 660 GQCNCKRHVSGRQCNQCQNGF 680



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 52/165 (31%), Positives = 68/165 (41%), Gaps = 37/165 (22%)

Query: 255 CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSC 313
           C+CN H S           C+C+   +G  C  C+  FY           +   C AC C
Sbjct: 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFY---------GLDVTNCKACDC 797

Query: 314 NGHARRCRFNMELYRLSGRRSGGVC------LNCRHNTAGRHCHYCREG-FYRDPGRALS 366
           +               +G   G VC        C+ N  GR C+ C EG FY     +  
Sbjct: 798 D--------------TAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSF- 842

Query: 367 DRRACRACDCHPVGAAGKT--CNQTTGQCPCKDGVTGLTCNRCAP 409
               C  C+C   G    +  CN++TGQCPCK GVTGL CN+C P
Sbjct: 843 ---LCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP 884



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 58/191 (30%), Positives = 73/191 (38%), Gaps = 45/191 (23%)

Query: 250 QVGGRCKCNGHAS-----RCL--------LDTQGHLICDCR-HGTEGPDC------GRCK 289
           Q+GG+C C  H S     +C         LD  G   C+C   GT   D       G+CK
Sbjct: 657 QIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCK 716

Query: 290 PF---------YCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLN 340
                      +C+  ++   +     C  C CN H    +F             G C  
Sbjct: 717 CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFC--------NPHSGQC-E 767

Query: 341 CRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAA-GKTCNQTTGQCPCKDGV 399
           C+    G  C  CRE FY        D   C+ACDC   G+  G  CN  TGQC CK  V
Sbjct: 768 CKKEAKGLQCDTCRENFYG------LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNV 821

Query: 400 TGLTCNRCAPG 410
            G  CN+C  G
Sbjct: 822 EGRQCNKCLEG 832



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 56/184 (30%), Positives = 76/184 (41%), Gaps = 35/184 (19%)

Query: 260  HASRCLLDTQGHL---ICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESHACL 309
            H   C  D+ G L   ICD       C    +G  C +C+P +   P           CL
Sbjct: 896  HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNAT------GCL 949

Query: 310  ACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCRE---GFYRDPGRALS 366
             CSC+        N     L+G+     C+    + AG+ C  C++   GF    GR   
Sbjct: 950  PCSCHTTGA---VNHICNSLTGQ-----CVCQDASIAGQRCDQCKDHYFGFDPQTGR--- 998

Query: 367  DRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQ-SRSPVAPCVKTP 425
                C+ C+CH  GA  +TC+  TGQC CK  VTG  C+ C P       + +  C KTP
Sbjct: 999  ----CQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTP 1054

Query: 426  IPGP 429
               P
Sbjct: 1055 FQQP 1058



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 52/220 (23%), Positives = 76/220 (34%), Gaps = 73/220 (33%)

Query: 255 CKCNGHASRCLLDTQ------------GHLICDCRHGTEGPDCGRCKPFYCDRPWQRATA 302
           C+CN H+  C  +              G +  DC H T G +C  CK ++  +     +A
Sbjct: 575 CQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSA 634

Query: 303 RESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYR--- 359
            +   C  C C+    R         +   + GG C NC+ + +GR C+ C+ GFY    
Sbjct: 635 ID--VCKPCDCDTVGTRNG------SILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQE 685

Query: 360 -DPG-----------------------------------------------RALSDRRAC 371
            DP                                                R+ +D   C
Sbjct: 686 LDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDV-GC 744

Query: 372 RACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
             C C+  G+  K CN  +GQC CK    GL C+ C   F
Sbjct: 745 EPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENF 784


>gi|219842259 usherin isoform A [Homo sapiens]
          Length = 1546

 Score =  163 bits (412), Expect = 5e-40
 Identities = 97/321 (30%), Positives = 151/321 (47%), Gaps = 23/321 (7%)

Query: 105 VTLTVPLGKA-FELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPA 163
           VT++V L    +++ ++ ++F S  P  + + + +++   W    +F+ +C    G    
Sbjct: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC----GAFGM 424

Query: 164 PANGPAGPGPEALCFPAPLAQPDGSGLLAFSMQDSSP---PGLD-LDSSPVLQDWVTATD 219
             NG         C       P   G + FS+    P   PG +   ++P LQ++V AT 
Sbjct: 425 KNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484

Query: 220 VRVVLTRPSTAGDPRDMEAVVPYS---YAATDLQVGGRCKCNGHASRCLLDTQGH-LICD 275
           +R         G     E  V      YA  ++ + GRC+C+GHA  C   +Q +  +C 
Sbjct: 485 IRFHFH-----GQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCS 539

Query: 276 CRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSG---R 332
               TEG  C RC P Y D+P+++     +  C  C CN H++ C +N+ +        R
Sbjct: 540 QESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFR 599

Query: 333 RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKT--CNQTT 390
             GGVC +C HNT GR+C  C++ F+R  G   S    C+ CDC  VG    +  C+Q  
Sbjct: 600 GGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIG 659

Query: 391 GQCPCKDGVTGLTCNRCAPGF 411
           GQC CK  V+G  CN+C  GF
Sbjct: 660 GQCNCKRHVSGRQCNQCQNGF 680



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 52/165 (31%), Positives = 68/165 (41%), Gaps = 37/165 (22%)

Query: 255 CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSC 313
           C+CN H S           C+C+   +G  C  C+  FY           +   C AC C
Sbjct: 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFY---------GLDVTNCKACDC 797

Query: 314 NGHARRCRFNMELYRLSGRRSGGVC------LNCRHNTAGRHCHYCREG-FYRDPGRALS 366
           +               +G   G VC        C+ N  GR C+ C EG FY     +  
Sbjct: 798 D--------------TAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSF- 842

Query: 367 DRRACRACDCHPVGAAGKT--CNQTTGQCPCKDGVTGLTCNRCAP 409
               C  C+C   G    +  CN++TGQCPCK GVTGL CN+C P
Sbjct: 843 ---LCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP 884



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 58/191 (30%), Positives = 73/191 (38%), Gaps = 45/191 (23%)

Query: 250 QVGGRCKCNGHAS-----RCL--------LDTQGHLICDCR-HGTEGPDC------GRCK 289
           Q+GG+C C  H S     +C         LD  G   C+C   GT   D       G+CK
Sbjct: 657 QIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCK 716

Query: 290 PF---------YCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLN 340
                      +C+  ++   +     C  C CN H    +F             G C  
Sbjct: 717 CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFC--------NPHSGQC-E 767

Query: 341 CRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAA-GKTCNQTTGQCPCKDGV 399
           C+    G  C  CRE FY        D   C+ACDC   G+  G  CN  TGQC CK  V
Sbjct: 768 CKKEAKGLQCDTCRENFYG------LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNV 821

Query: 400 TGLTCNRCAPG 410
            G  CN+C  G
Sbjct: 822 EGRQCNKCLEG 832



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 56/184 (30%), Positives = 76/184 (41%), Gaps = 35/184 (19%)

Query: 260  HASRCLLDTQGHL---ICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESHACL 309
            H   C  D+ G L   ICD       C    +G  C +C+P +   P           CL
Sbjct: 896  HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNAT------GCL 949

Query: 310  ACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCRE---GFYRDPGRALS 366
             CSC+        N     L+G+     C+    + AG+ C  C++   GF    GR   
Sbjct: 950  PCSCHTTGA---VNHICNSLTGQ-----CVCQDASIAGQRCDQCKDHYFGFDPQTGR--- 998

Query: 367  DRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQ-SRSPVAPCVKTP 425
                C+ C+CH  GA  +TC+  TGQC CK  VTG  C+ C P       + +  C KTP
Sbjct: 999  ----CQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTP 1054

Query: 426  IPGP 429
               P
Sbjct: 1055 FQQP 1058



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 52/220 (23%), Positives = 76/220 (34%), Gaps = 73/220 (33%)

Query: 255 CKCNGHASRCLLDTQ------------GHLICDCRHGTEGPDCGRCKPFYCDRPWQRATA 302
           C+CN H+  C  +              G +  DC H T G +C  CK ++  +     +A
Sbjct: 575 CQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSA 634

Query: 303 RESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYR--- 359
            +   C  C C+    R         +   + GG C NC+ + +GR C+ C+ GFY    
Sbjct: 635 ID--VCKPCDCDTVGTRNG------SILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQE 685

Query: 360 -DPG-----------------------------------------------RALSDRRAC 371
            DP                                                R+ +D   C
Sbjct: 686 LDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDV-GC 744

Query: 372 RACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
             C C+  G+  K CN  +GQC CK    GL C+ C   F
Sbjct: 745 EPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENF 784


>gi|54312078 netrin G1 isoform 3 [Homo sapiens]
          Length = 438

 Score =  124 bits (311), Expect = 2e-28
 Identities = 103/361 (28%), Positives = 146/361 (40%), Gaps = 48/361 (13%)

Query: 58  TCGRP------------ATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPR--APL 103
           TCG P                CDAS P  AH P L+    G      W+S +      PL
Sbjct: 71  TCGDPPETFCAMGNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPL 130

Query: 104 NVTLTVPLGKAFELVF-VSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLP 162
            V +T+   K  EL   + + F S  P  + L KS D+GR+W P  ++++ C LD   + 
Sbjct: 131 QVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDC-LDAFHMD 189

Query: 163 APANGPAGPGP--EALCFPA-PLAQPDGSGLLAFSMQDS----SPPGL--------DLDS 207
             +          E +C           S ++ F ++D     + P L         LD+
Sbjct: 190 PKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASLYGQLDT 249

Query: 208 SPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLD 267
           +  L+D+ T TD+R+ L RP+      D   +  Y YA +D++V GRCKCN HA+ C+ D
Sbjct: 250 TKKLRDFFTVTDLRIRLLRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNLHATVCVYD 309

Query: 268 TQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELY 327
               L C+C H T GPDCG+CK  Y  RPW   +        A +C         N+   
Sbjct: 310 -NSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGTNVCDN 368

Query: 328 RLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCN 387
            L   ++GG C    HN     C     G              C    C   G+ G    
Sbjct: 369 ELLHCQNGGTC----HNNVRCLCPAAYTGI------------LCEKLRCEEAGSCGSDSG 412

Query: 388 Q 388
           Q
Sbjct: 413 Q 413



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 30/124 (24%), Positives = 51/124 (41%), Gaps = 12/124 (9%)

Query: 364 ALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVK 423
           A+SD +    C C+ + A     + +   C C+   TG  C +C   +Q    P +P   
Sbjct: 287 AISDIKVRGRCKCN-LHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQ--GRPWSPGSY 343

Query: 424 TPIPGPTEDS-----SPVQPQDCDS---HCKPARGSYRISLKKFCKKDYAVQVAVGARGE 475
            PIP  T ++     S +    CD+   HC+   G+   +++  C   Y   +    R E
Sbjct: 344 LPIPKGTANTCIPSISSIGTNVCDNELLHCQNG-GTCHNNVRCLCPAAYTGILCEKLRCE 402

Query: 476 ARGA 479
             G+
Sbjct: 403 EAGS 406


>gi|164414437 netrin G1 isoform 2 [Homo sapiens]
          Length = 480

 Score =  123 bits (308), Expect = 5e-28
 Identities = 87/270 (32%), Positives = 124/270 (45%), Gaps = 32/270 (11%)

Query: 58  TCGRP------------ATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPR--APL 103
           TCG P                CDAS P  AH P L+    G      W+S +      PL
Sbjct: 71  TCGDPPETFCAMGNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPL 130

Query: 104 NVTLTVPLGKAFELVF-VSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLP 162
            V +T+   K  EL   + + F S  P  + L KS D+GR+W P  ++++ C LD   + 
Sbjct: 131 QVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDC-LDAFHMD 189

Query: 163 APANGPAGPGP--EALCFPA-PLAQPDGSGLLAFSMQDS----SPPGL--------DLDS 207
             +          E +C           S ++ F ++D     + P L         LD+
Sbjct: 190 PKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASLYGQLDT 249

Query: 208 SPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLD 267
           +  L+D+ T TD+R+ L RP+      D   +  Y YA +D++V GRCKCN HA+ C+ D
Sbjct: 250 TKKLRDFFTVTDLRIRLLRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNLHATVCVYD 309

Query: 268 TQGHLICDCRHGTEGPDCGRCKPFYCDRPW 297
               L C+C H T GPDCG+CK  Y  RPW
Sbjct: 310 -NSKLTCECEHNTTGPDCGKCKKNYQGRPW 338


>gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]
          Length = 1111

 Score =  105 bits (261), Expect = 1e-22
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 24/179 (13%)

Query: 286 GRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNT 345
           G C  F    P  RAT+R       C CNG +R+C F+ EL+R +G  +G  CLNC  NT
Sbjct: 7   GCCLCFSLLLPAARATSRRE----VCDCNGKSRQCIFDRELHRQTG--NGFRCLNCNDNT 60

Query: 346 AGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCN 405
            G HC  C+ GFYR       +R  C  C+C+  G+    C+  +G+C CK GVTG  C+
Sbjct: 61  DGIHCEKCKNGFYRH-----RERDRCLPCNCNSKGSLSARCD-NSGRCSCKPGVTGARCD 114

Query: 406 RCAPGF-----------QQSRSPVAPCVKTPIPGPTEDSSPV-QPQDCDSHCKPARGSY 452
           RC PGF           Q+       C    I GP +    V +P      C   R  Y
Sbjct: 115 RCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGY 173



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 53/167 (31%), Positives = 68/167 (40%), Gaps = 31/167 (18%)

Query: 255 CKCNGHASRCLLDTQ-------GHLICDCRHGTEGPDCGRCK-PFYCDRPWQRATARESH 306
           C CNG + +C+ D +       G    +C   T+G  C +CK  FY          RE  
Sbjct: 28  CDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFY--------RHRERD 79

Query: 307 ACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY--RDPGRA 364
            CL C+CN              LS R       +C+    G  C  C  GF+   D G  
Sbjct: 80  RCLPCNCNSKG----------SLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCT 129

Query: 365 LSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
              R     CDC P G AG  C+   G+C CK  VTG  C+RC  G+
Sbjct: 130 QDQRLLDSKCDCDPAGIAG-PCD--AGRCVCKPAVTGERCDRCRSGY 173



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 51/156 (32%), Positives = 72/156 (46%), Gaps = 13/156 (8%)

Query: 255 CKC-NGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPW-QRATARESHACLACS 312
           C C NG +   + +T+  +  +C  G  G  C  C   Y   P+ +    R    C  C 
Sbjct: 462 CPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRP---CQPCQ 518

Query: 313 CNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACR 372
           CN +           RL+GR     CL C HNTAG +C  C+ G++ DP  A +    CR
Sbjct: 519 CNNNVDPSASG-NCDRLTGR-----CLKCIHNTAGIYCDQCKAGYFGDP-LAPNPADKCR 571

Query: 373 ACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCA 408
           AC+C+P+G+    C ++ G C CK G  G  C   A
Sbjct: 572 ACNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEHGA 606



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 49/184 (26%), Positives = 65/184 (35%), Gaps = 48/184 (26%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESH--ACLACSCNGHARRCRFNMELYRLSG 331
           C C  G +G  C  C   Y     +R +AR      C+ C+C G         + Y  SG
Sbjct: 382 CICPVGYKGQFCQDCASGY-----KRDSARLGPFGTCIPCNCQGGGACDPDTGDCY--SG 434

Query: 332 RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCH---PVGAAGKTCNQ 388
             +  +            C  C  GFY DP     D R+C+ C CH         +T   
Sbjct: 435 DENPDI-----------ECADCPIGFYNDP----HDPRSCKPCPCHNGFSCSVMPETEEV 479

Query: 389 TTGQCPCKDGVTGLTCNRCAPGF----QQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSH 444
               CP   GVTG  C  CA G+         PV PC               QP  C+++
Sbjct: 480 VCNNCP--PGVTGARCELCADGYFGDPFGEHGPVRPC---------------QPCQCNNN 522

Query: 445 CKPA 448
             P+
Sbjct: 523 VDPS 526



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 33/126 (26%), Positives = 44/126 (34%), Gaps = 22/126 (17%)

Query: 255 CKCNGHAS---RCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLAC 311
           C CN   S   RC  D  G   C C+ G  G  C RC P +        T  +      C
Sbjct: 84  CNCNSKGSLSARC--DNSGR--CSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKC 139

Query: 312 SCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRAC 371
            C+              ++G    G C+ C+    G  C  CR G+Y   G    +   C
Sbjct: 140 DCDPAG-----------IAGPCDAGRCV-CKPAVTGERCDRCRSGYYNLDG---GNPEGC 184

Query: 372 RACDCH 377
             C C+
Sbjct: 185 TQCFCY 190



 Score = 32.7 bits (73), Expect = 0.94
 Identities = 15/52 (28%), Positives = 20/52 (38%), Gaps = 5/52 (9%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNME 325
           C C+    G  C RC+  Y +             C  C C GH+  CR + E
Sbjct: 155 CVCKPAVTGERCDRCRSGYYN-----LDGGNPEGCTQCFCYGHSASCRSSAE 201


>gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]
          Length = 1193

 Score =  105 bits (261), Expect = 1e-22
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 24/179 (13%)

Query: 286 GRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNT 345
           G C  F    P  RAT+R       C CNG +R+C F+ EL+R +G  +G  CLNC  NT
Sbjct: 7   GCCLCFSLLLPAARATSRRE----VCDCNGKSRQCIFDRELHRQTG--NGFRCLNCNDNT 60

Query: 346 AGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCN 405
            G HC  C+ GFYR       +R  C  C+C+  G+    C+  +G+C CK GVTG  C+
Sbjct: 61  DGIHCEKCKNGFYRH-----RERDRCLPCNCNSKGSLSARCD-NSGRCSCKPGVTGARCD 114

Query: 406 RCAPGF-----------QQSRSPVAPCVKTPIPGPTEDSSPV-QPQDCDSHCKPARGSY 452
           RC PGF           Q+       C    I GP +    V +P      C   R  Y
Sbjct: 115 RCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGY 173



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 53/167 (31%), Positives = 68/167 (40%), Gaps = 31/167 (18%)

Query: 255 CKCNGHASRCLLDTQ-------GHLICDCRHGTEGPDCGRCK-PFYCDRPWQRATARESH 306
           C CNG + +C+ D +       G    +C   T+G  C +CK  FY          RE  
Sbjct: 28  CDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFY--------RHRERD 79

Query: 307 ACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFY--RDPGRA 364
            CL C+CN              LS R       +C+    G  C  C  GF+   D G  
Sbjct: 80  RCLPCNCNSKG----------SLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCT 129

Query: 365 LSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411
              R     CDC P G AG  C+   G+C CK  VTG  C+RC  G+
Sbjct: 130 QDQRLLDSKCDCDPAGIAG-PCD--AGRCVCKPAVTGERCDRCRSGY 173



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 51/156 (32%), Positives = 72/156 (46%), Gaps = 13/156 (8%)

Query: 255 CKC-NGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPW-QRATARESHACLACS 312
           C C NG +   + +T+  +  +C  G  G  C  C   Y   P+ +    R    C  C 
Sbjct: 462 CPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRP---CQPCQ 518

Query: 313 CNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACR 372
           CN +           RL+GR     CL C HNTAG +C  C+ G++ DP  A +    CR
Sbjct: 519 CNNNVDPSASG-NCDRLTGR-----CLKCIHNTAGIYCDQCKAGYFGDP-LAPNPADKCR 571

Query: 373 ACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCA 408
           AC+C+P+G+    C ++ G C CK G  G  C   A
Sbjct: 572 ACNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEHGA 606



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 49/184 (26%), Positives = 65/184 (35%), Gaps = 48/184 (26%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESH--ACLACSCNGHARRCRFNMELYRLSG 331
           C C  G +G  C  C   Y     +R +AR      C+ C+C G         + Y  SG
Sbjct: 382 CICPVGYKGQFCQDCASGY-----KRDSARLGPFGTCIPCNCQGGGACDPDTGDCY--SG 434

Query: 332 RRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCH---PVGAAGKTCNQ 388
             +  +            C  C  GFY DP     D R+C+ C CH         +T   
Sbjct: 435 DENPDI-----------ECADCPIGFYNDP----HDPRSCKPCPCHNGFSCSVMPETEEV 479

Query: 389 TTGQCPCKDGVTGLTCNRCAPGF----QQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSH 444
               CP   GVTG  C  CA G+         PV PC               QP  C+++
Sbjct: 480 VCNNCP--PGVTGARCELCADGYFGDPFGEHGPVRPC---------------QPCQCNNN 522

Query: 445 CKPA 448
             P+
Sbjct: 523 VDPS 526



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 33/126 (26%), Positives = 44/126 (34%), Gaps = 22/126 (17%)

Query: 255 CKCNGHAS---RCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLAC 311
           C CN   S   RC  D  G   C C+ G  G  C RC P +        T  +      C
Sbjct: 84  CNCNSKGSLSARC--DNSGR--CSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKC 139

Query: 312 SCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRAC 371
            C+              ++G    G C+ C+    G  C  CR G+Y   G    +   C
Sbjct: 140 DCDPAG-----------IAGPCDAGRCV-CKPAVTGERCDRCRSGYYNLDG---GNPEGC 184

Query: 372 RACDCH 377
             C C+
Sbjct: 185 TQCFCY 190



 Score = 32.7 bits (73), Expect = 0.94
 Identities = 15/52 (28%), Positives = 20/52 (38%), Gaps = 5/52 (9%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNME 325
           C C+    G  C RC+  Y +             C  C C GH+  CR + E
Sbjct: 155 CVCKPAVTGERCDRCRSGYYN-----LDGGNPEGCTQCFCYGHSASCRSSAE 201


>gi|189217428 laminin alpha 3 subunit isoform 4 [Homo sapiens]
          Length = 1668

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 57/157 (36%), Positives = 75/157 (47%), Gaps = 37/157 (23%)

Query: 308 CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSD 367
           C+ C+CNGH+ +C+              G+C+NC+HNTAG HC  C+EG+Y   G A+  
Sbjct: 75  CVPCNCNGHSNQCQ-----------DGSGICVNCQHNTAGEHCERCQEGYY---GNAV-- 118

Query: 368 RRACRACDCHPVG--AAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF----QQSRSPVAPC 421
             +CRAC C      A G   N    +C CK G TG  C RCAPG+    Q+      PC
Sbjct: 119 HGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPC 178

Query: 422 VKT---------PIPG-----PTEDSSPVQP-QDCDS 443
                       P+ G       +DSSP +   DCDS
Sbjct: 179 SCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDS 215



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 45/157 (28%), Positives = 64/157 (40%), Gaps = 25/157 (15%)

Query: 255 CKCNGHASRCLLDTQGHLIC-DCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSC 313
           C CNGH+++C     G  IC +C+H T G  C RC+  Y    +  A      AC     
Sbjct: 78  CNCNGHSNQC---QDGSGICVNCQHNTAGEHCERCQEGY----YGNAVHGSCRACPCPHT 130

Query: 314 NGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRA 373
           N  A  C  N           G V  +C+    G  C  C  G++ +P +      +C+ 
Sbjct: 131 NSFATGCVVN----------GGDVRCSCKAGYTGTQCERCAPGYFGNPQKF---GGSCQP 177

Query: 374 CDCHPVGAAGKTCNQTTGQC---PCKDGVTGLTCNRC 407
           C C+  G  G +C+  TG C     KD      C+ C
Sbjct: 178 CSCNSNGQLG-SCHPLTGDCINQEPKDSSPAEECDDC 213


>gi|38045908 laminin alpha 3 subunit isoform 2 [Homo sapiens]
          Length = 1724

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 57/157 (36%), Positives = 75/157 (47%), Gaps = 37/157 (23%)

Query: 308 CLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSD 367
           C+ C+CNGH+ +C+              G+C+NC+HNTAG HC  C+EG+Y   G A+  
Sbjct: 75  CVPCNCNGHSNQCQ-----------DGSGICVNCQHNTAGEHCERCQEGYY---GNAV-- 118

Query: 368 RRACRACDCHPVG--AAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF----QQSRSPVAPC 421
             +CRAC C      A G   N    +C CK G TG  C RCAPG+    Q+      PC
Sbjct: 119 HGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPC 178

Query: 422 VKT---------PIPG-----PTEDSSPVQP-QDCDS 443
                       P+ G       +DSSP +   DCDS
Sbjct: 179 SCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDS 215



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 45/157 (28%), Positives = 64/157 (40%), Gaps = 25/157 (15%)

Query: 255 CKCNGHASRCLLDTQGHLIC-DCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSC 313
           C CNGH+++C     G  IC +C+H T G  C RC+  Y    +  A      AC     
Sbjct: 78  CNCNGHSNQC---QDGSGICVNCQHNTAGEHCERCQEGY----YGNAVHGSCRACPCPHT 130

Query: 314 NGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRA 373
           N  A  C  N           G V  +C+    G  C  C  G++ +P +      +C+ 
Sbjct: 131 NSFATGCVVN----------GGDVRCSCKAGYTGTQCERCAPGYFGNPQKF---GGSCQP 177

Query: 374 CDCHPVGAAGKTCNQTTGQC---PCKDGVTGLTCNRC 407
           C C+  G  G +C+  TG C     KD      C+ C
Sbjct: 178 CSCNSNGQLG-SCHPLTGDCINQEPKDSSPAEECDDC 213


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 56/169 (33%), Positives = 77/169 (45%), Gaps = 30/169 (17%)

Query: 254  RCKCNGHASRCLLDTQGHLICD-CRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLAC 311
            RC C+GH+  C  +T     C  C+H TEGP C +C+P +Y D   QR T ++   C  C
Sbjct: 1158 RCSCHGHSEACEPETGA---CQGCQHHTEGPRCEQCQPGYYGDA--QRGTPQD---CQLC 1209

Query: 312  SCNGH------ARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRAL 365
             C G       A  C  + +            C  C    +GRHC  C  G+Y +P +  
Sbjct: 1210 PCYGDPAAGQAAHTCFLDTD--------GHPTCDACSPGHSGRHCERCAPGYYGNPSQGQ 1261

Query: 366  SDRRACR-----ACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAP 409
              +R  +      C+C P G+    C+   GQC CK  V GLTC+ C P
Sbjct: 1262 PCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQCQCKAQVEGLTCSHCRP 1309



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 53/164 (32%), Positives = 70/164 (42%), Gaps = 25/164 (15%)

Query: 274  CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
            C C  G  GP C  C   Y   P    +      C  CSC+GH+  C             
Sbjct: 1126 CSCPPGYRGPSCQDCDTGYTRTP----SGLYLGTCERCSCHGHSEACE-----------P 1170

Query: 334  SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGK---TCNQTT 390
              G C  C+H+T G  C  C+ G+Y D  R     + C+ C C+   AAG+   TC   T
Sbjct: 1171 ETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTP--QDCQLCPCYGDPAAGQAAHTCFLDT 1228

Query: 391  GQCP----CKDGVTGLTCNRCAPGFQQSRSPVAPCVK-TPIPGP 429
               P    C  G +G  C RCAPG+  + S   PC + + +PGP
Sbjct: 1229 DGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGP 1272



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 52/154 (33%), Positives = 69/154 (44%), Gaps = 26/154 (16%)

Query: 274 CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
           C C  G  G  C  C   +   P           C  C+CNGHA  C     +Y      
Sbjct: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLG----TCSGCNCNGHASSCD---PVY------ 777

Query: 334 SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGK---TC-NQT 389
             G CLNC+HNT G  C+ C+ GF+ D  +A +   +CR C C  + A+ +   TC   T
Sbjct: 778 --GHCLNCQHNTEGPQCNKCKAGFFGDAMKATA--TSCRPCPCPYIDASRRFSDTCFLDT 833

Query: 390 TGQC---PCKDGVTGLTCNRCAPGFQQSRSPVAP 420
            GQ     C  G TG  C  CAPG++   +P+ P
Sbjct: 834 DGQATCDACAPGYTGRRCESCAPGYE--GNPIQP 865



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 42/145 (28%), Positives = 55/145 (37%), Gaps = 24/145 (16%)

Query: 274  CDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRR 333
            C C  G  G  C  C P Y     +  +      C  C CNGH+  C             
Sbjct: 1530 CRCPPGYIGLSCQDCAPGYT----RTGSGLYLGHCELCECNGHSDLCH-----------P 1574

Query: 334  SGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDC---HPVGAAGKTCNQTT 390
              G C  C+HN AG  C  C  G+Y D      +   C+ C C   +P     +TC    
Sbjct: 1575 ETGACSQCQHNAAGEFCELCAPGYYGDATAGTPE--DCQPCACPLTNPENMFSRTCESLG 1632

Query: 391  G---QC-PCKDGVTGLTCNRCAPGF 411
                +C  C+ G TG  C +C PG+
Sbjct: 1633 AGGYRCTACEPGYTGQYCEQCGPGY 1657



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 32/113 (28%), Positives = 43/113 (38%), Gaps = 20/113 (17%)

Query: 255  CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSC- 313
            C+CNGH+  C  +T       C+H   G  C  C P Y    +  ATA     C  C+C 
Sbjct: 1563 CECNGHSDLCHPETGA--CSQCQHNAAGEFCELCAPGY----YGDATAGTPEDCQPCACP 1616

Query: 314  -----NGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDP 361
                 N  +R C         S    G  C  C     G++C  C  G+  +P
Sbjct: 1617 LTNPENMFSRTCE--------SLGAGGYRCTACEPGYTGQYCEQCGPGYVGNP 1661



 Score = 37.7 bits (86), Expect = 0.029
 Identities = 31/128 (24%), Positives = 44/128 (34%), Gaps = 12/128 (9%)

Query: 341  CRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCP-CKDGV 399
            C     G  C  C  G+ R           C  C+C+        C+  TG C  C+   
Sbjct: 1532 CPPGYIGLSCQDCAPGYTRTGSGLYLGH--CELCECN---GHSDLCHPETGACSQCQHNA 1586

Query: 400  TGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKF 459
             G  C  CAPG+    +   P    P   P  +   +  + C+S      G YR +    
Sbjct: 1587 AGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCES---LGAGGYRCTA--- 1640

Query: 460  CKKDYAVQ 467
            C+  Y  Q
Sbjct: 1641 CEPGYTGQ 1648



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 14/93 (15%)

Query: 234 RDMEAVVPYSYAATDLQVGGRCK-CNGHASRCLLDTQGHL-----ICDCRHGTEGPDCGR 287
           R  E+  P  Y    +Q GG+C+  N    RC  D +G +      C C++   G  C  
Sbjct: 849 RRCESCAP-GYEGNPIQPGGKCRPVNQEIVRC--DERGSMGTSGEACRCKNNVVGRLCNE 905

Query: 288 CKPFYCDRPWQRATARESHACLACSCNGHARRC 320
           C     D  +  +T R    CL C C G +R C
Sbjct: 906 C----ADGSFHLST-RNPDGCLKCFCMGVSRHC 933



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 24/78 (30%), Positives = 32/78 (41%), Gaps = 14/78 (17%)

Query: 248  DLQVGGRCKCN-----GHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATA 302
            D QV G   CN       +S+C  D  G   C C+   EG  C  C+P +        +A
Sbjct: 1266 DSQVPGPIGCNCDPQGSVSSQC--DAAGQ--CQCKAQVEGLTCSHCRPHHF-----HLSA 1316

Query: 303  RESHACLACSCNGHARRC 320
                 CL C C G  ++C
Sbjct: 1317 SNPDGCLPCFCMGITQQC 1334



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 11/25 (44%), Positives = 16/25 (64%)

Query: 392  QCPCKDGVTGLTCNRCAPGFQQSRS 416
            +C C  G  GL+C  CAPG+ ++ S
Sbjct: 1529 ECRCPPGYIGLSCQDCAPGYTRTGS 1553


>gi|122937440 multiple EGF-like-domains 9 [Homo sapiens]
          Length = 639

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 122/508 (24%), Positives = 167/508 (32%), Gaps = 128/508 (25%)

Query: 9   LLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRPATRACD 68
           LL      AA +    A A      GGA      G V+A+ G  +    +   P   A  
Sbjct: 12  LLCCAAAAAAAAVASAASAGNVTGGGGAA-----GQVDASPGPGLRGEPSHPFPRATAPT 66

Query: 69  ASDPRRA------HSPALLTSPGGT--ASPLCWRSESLPRAPLNVTLTVPLGKAFELVFV 120
           A  PR        H P   TSP  +   +PL W +      P + T   PLG +      
Sbjct: 67  AQAPRTGPPRATVHRPLAATSPAQSPETTPL-WATAG----PSSTTFQAPLGPS------ 115

Query: 121 SLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPA 180
                + PPA+     +       AP    ++              GPA   P A   PA
Sbjct: 116 ----PTTPPAAERTSTTSQAPTRPAPTTLSTT-------------TGPAPTTPVATTVPA 158

Query: 181 PLAQPDGSGLLAFSMQDS---SPPGLDLDSSPVL-QDWVTATDVRVVLTRPSTAGDPRDM 236
           P      +  L  S   S   +PP  +  SSP     W  A   +  L + +   + +  
Sbjct: 159 PTTPRTPTPDLPSSSNSSVLPTPPATEAPSSPPPGHQWPVAKMPQKYLGKYACESNLKSK 218

Query: 237 EAVVPYSYAATDLQVGGRCK----CNG------HASRCLLDTQGHLICDCRHGTEGPDCG 286
              +P +    +L+V    K    CN       + +RC   T G   C+CR G +G  C 
Sbjct: 219 --YLPLTQPVMNLRVSEAVKTEYVCNCSVVGSLNVNRCN-QTTGQ--CECRPGYQGLHCE 273

Query: 287 RCKP-FY---------------------------------------CDRPWQRATARESH 306
            CK  FY                                       CDR          +
Sbjct: 274 TCKEGFYLNYTSGLCQPCDCSPHGALSIPCNSSGKCQCKVGVIGSICDRCQDGYYGFSKN 333

Query: 307 ACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALS 366
            CL C CN  +  C               G CLNC+ N+ G HC  C+EGFY+ P     
Sbjct: 334 GCLPCQCNNRSASC-----------DALTGACLNCQENSKGNHCEECKEGFYQSPDAT-- 380

Query: 367 DRRACRACDCHPVGAAGKTCNQTTGQCP----CKDGVTGLTCNRCAPGFQQSRSPVAPCV 422
             + C  C C  V + G    +++   P    CKDG  G  CN+C  G+    S    C 
Sbjct: 381 --KECLRCPCSAVTSTGSCSIKSSELEPECDQCKDGYIGPNCNKCENGYYNFDSICRKC- 437

Query: 423 KTPIPGPTEDSSPVQPQDCDSHCKPARG 450
                   +    V P      CKP  G
Sbjct: 438 --------QCHGHVDPVKTPKICKPESG 457



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 31/111 (27%), Positives = 44/111 (39%), Gaps = 18/111 (16%)

Query: 254 RCKCNGHASRCLLDTQGHLI---CD-CRHGTEGPDCGRCKPFYCDRPWQRATARESHACL 309
           RC C+   S      +   +   CD C+ G  GP+C +C+  Y +             C 
Sbjct: 385 RCPCSAVTSTGSCSIKSSELEPECDQCKDGYIGPNCNKCENGYYNF---------DSICR 435

Query: 310 ACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRD 360
            C C+GH    +          +   G C+NC HNT G  C  C EG+  D
Sbjct: 436 KCQCHGHVDPVKTPKIC-----KPESGECINCLHNTTGFWCENCLEGYVHD 481


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.468 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,727,764
Number of Sequences: 37866
Number of extensions: 1819057
Number of successful extensions: 11375
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 226
Number of HSP's that attempted gapping in prelim test: 9567
Number of HSP's gapped (non-prelim): 1246
length of query: 580
length of database: 18,247,518
effective HSP length: 108
effective length of query: 472
effective length of database: 14,157,990
effective search space: 6682571280
effective search space used: 6682571280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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