Search of human proteins with 53832026

Search of human proteins with 53832026

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
         (949 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]      1913   0.0  
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]      1823   0.0  
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]      1002   0.0  
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      999   0.0  
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 573   e-163
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   158   3e-38
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     153   8e-37
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       153   8e-37
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   147   4e-35
gi|4758968 cytohesin 3 [Homo sapiens]                                 147   4e-35
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     147   4e-35
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       147   4e-35
gi|7019505 cytohesin 4 [Homo sapiens]                                 139   1e-32
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   132   1e-30
gi|48928044 F-box only protein 8 [Homo sapiens]                       107   5e-23
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      104   4e-22
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]     88   3e-17
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...    84   5e-16
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...    84   5e-16
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]     83   1e-15
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]         49   2e-05
gi|116256464 hypothetical protein LOC343990 [Homo sapiens]             49   3e-05
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     49   3e-05
gi|239749251 PREDICTED: similar to hCG2042508 [Homo sapiens]           48   4e-05
gi|239743343 PREDICTED: similar to hCG2042508 [Homo sapiens]           48   4e-05
gi|239509031 PREDICTED: similar to hCG2042508 [Homo sapiens]           48   4e-05
gi|47271406 bin3, bicoid-interacting 3 [Homo sapiens]                  47   6e-05
gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Ho...    47   6e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        47   6e-05
gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein ...    46   1e-04

>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score = 1913 bits (4955), Expect = 0.0
 Identities = 949/949 (100%), Positives = 949/949 (100%)

Query: 1   MEPPGRSSRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGS 60
           MEPPGRSSRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGS
Sbjct: 1   MEPPGRSSRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDAPGSDLSTAVDSPGS 60

Query: 61  QPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYEL 120
           QPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYEL
Sbjct: 61  QPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYEL 120

Query: 121 STDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIIL 180
           STDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIIL
Sbjct: 121 STDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIIL 180

Query: 181 SNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGS 240
           SNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGS
Sbjct: 181 SNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGS 240

Query: 241 SVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQ 300
           SVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQ
Sbjct: 241 SVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQ 300

Query: 301 EDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTRED 360
           EDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTRED
Sbjct: 301 EDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTRED 360

Query: 361 GSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADG 420
           GSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADG
Sbjct: 361 GSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADG 420

Query: 421 CSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCE 480
           CSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCE
Sbjct: 421 CSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCE 480

Query: 481 AAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSP 540
           AAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSP
Sbjct: 481 AAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSP 540

Query: 541 AFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGE 600
           AFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGE
Sbjct: 541 AFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGE 600

Query: 601 FLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYC 660
           FLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYC
Sbjct: 601 FLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYC 660

Query: 661 VCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIP 720
           VCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIP
Sbjct: 661 VCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIP 720

Query: 721 RDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPN 780
           RDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPN
Sbjct: 721 RDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPN 780

Query: 781 RPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIK 840
           RPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIK
Sbjct: 781 RPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIK 840

Query: 841 LLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPN 900
           LLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPN
Sbjct: 841 LLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPN 900

Query: 901 ASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGVCY 949
           ASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGVCY
Sbjct: 901 ASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGVCY 949


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 1823 bits (4722), Expect = 0.0
 Identities = 906/906 (100%), Positives = 906/906 (100%)

Query: 41   SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVAL 100
            SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVAL
Sbjct: 246  SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVAL 305

Query: 101  RKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNK 160
            RKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNK
Sbjct: 306  RKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNK 365

Query: 161  NFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHR 220
            NFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHR
Sbjct: 366  NFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHR 425

Query: 221  LERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSG 280
            LERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSG
Sbjct: 426  LERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSG 485

Query: 281  PMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEF 340
            PMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEF
Sbjct: 486  PMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEF 545

Query: 341  WAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVD 400
            WAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVD
Sbjct: 546  WAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVD 605

Query: 401  LSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPA 460
            LSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPA
Sbjct: 606  LSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPA 665

Query: 461  PNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPP 520
            PNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPP
Sbjct: 666  PNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPP 725

Query: 521  ATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTP 580
            ATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTP
Sbjct: 726  ATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTP 785

Query: 581  VGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIR 640
            VGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIR
Sbjct: 786  VGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIR 845

Query: 641  VQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERK 700
            VQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERK
Sbjct: 846  VQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERK 905

Query: 701  MKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVL 760
            MKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVL
Sbjct: 906  MKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVL 965

Query: 761  SLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSF 820
            SLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSF
Sbjct: 966  SLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSF 1025

Query: 821  PLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQE 880
            PLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQE
Sbjct: 1026 PLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQE 1085

Query: 881  MEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLR 940
            MEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLR
Sbjct: 1086 MEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLR 1145

Query: 941  DLSDAG 946
            DLSDAG
Sbjct: 1146 DLSDAG 1151



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 55/193 (28%), Positives = 65/193 (33%), Gaps = 43/193 (22%)

Query: 320  PQQSPERLPSTEPPPQGRPEF-------WAPAPLPPVPP--------PVPSGTRED-GSR 363
            P   P + PS  PPPQ  P           PA  PPV P        PVP       G  
Sbjct: 1280 PPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRP 1339

Query: 364  EEGTRRGPGCLECRDFRLRAAH--------LPLLTIEPPSDSSVDLSDRSDRGSVHRQLV 415
                RRG G      F     H        LPL +  P    +     +    S H Q++
Sbjct: 1340 GRAPRRGAG--GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMM 1397

Query: 416  YEADGCS------PHGTLKHKGPP-----GRAPI-PHRHYPAPEGPAP-APPGPLPP--- 459
              A          P G+  H   P       +PI PH  YP    P+P  P  PLPP   
Sbjct: 1398 PAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSP 1457

Query: 460  -APNSGTGPSGVA 471
              P   +GP G A
Sbjct: 1458 HGPLHASGPPGTA 1470



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 41/159 (25%), Positives = 52/159 (32%), Gaps = 34/159 (21%)

Query: 337  RPEFWAPAPLPPVPP-------PVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 389
            RP    P P PP PP       PV + +   GS   G++RG G  +              
Sbjct: 1175 RPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLF-GSKRGKGPFQ-------------- 1219

Query: 390  TIEPPSDSSVDLSDRS-----------DRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPI 438
             + PP       S  S             G  H  L    DG S    L  +   G  P 
Sbjct: 1220 -MPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPA 1278

Query: 439  PHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLG 477
            P  + P  +   P PP   PP P  G+ P   A    +G
Sbjct: 1279 PPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVG 1317


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score = 1002 bits (2590), Expect = 0.0
 Identities = 576/953 (60%), Positives = 694/953 (72%), Gaps = 84/953 (8%)

Query: 39  ESSVEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ--- 89
           +S VEG+AP S+  T++DSP + P   L    S  P    H      G+  G P  Q   
Sbjct: 20  DSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRT 79

Query: 90  -RARLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAAR 147
            R +LQ ++  LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG  ++R AAR
Sbjct: 80  RRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAAR 139

Query: 148 TIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPAS 207
           TIQTAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE  EK  + +YFEGK  S
Sbjct: 140 TIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQVS 198

Query: 208 L-DEGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVKS 265
           + ++G+  GA              CG   +     S   S +F++ ITELED+FS+QVKS
Sbjct: 199 VTNDGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKS 249

Query: 266 LAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYLD 316
           LAESID+ALNC  S    E P       R+++ Q           D    S+SD+ LY+D
Sbjct: 250 LAESIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYID 308

Query: 317 DT-----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSREE 365
           +      +P  Q+ +R  STE   + R     P++WA A             +ED +  +
Sbjct: 309 EEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADTD 356

Query: 366 GTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHG 425
            + R    LE ++ RLR  HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ  YE       G
Sbjct: 357 TSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQG 416

Query: 426 TLKHKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGE 484
           + KH GP   AP   +  P  E    P PP PL    +S    +G A   R  K E+  +
Sbjct: 417 SPKH-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES--D 464

Query: 485 NSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNN 544
            SDG DN+S+ S+SNSN+TINCSS SSSRDSLRE     L KQTY +E R+SWDSPAF+N
Sbjct: 465 YSDG-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFSN 520

Query: 545 DVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGN 604
           DV+++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLGN
Sbjct: 521 DVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGN 580

Query: 605 RQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNP 664
           RQKQFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CNP
Sbjct: 581 RQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNP 640

Query: 665 ALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLL 724
            +VRQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++L
Sbjct: 641 GVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREML 700

Query: 725 VGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQLY 774
           +GIY+RI+ REL+TN+DHVSQVQ VE++IVGKKP          VLSLPHRRLVC C+L+
Sbjct: 701 MGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLF 760

Query: 775 EVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSY 834
           EVPDPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK  VTYSFRQSF L  M + LF+N Y
Sbjct: 761 EVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQY 820

Query: 835 YQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQK 894
           Y  GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQK
Sbjct: 821 YPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 880

Query: 895 GMMRPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAG 946
           G++RP+ SQ     K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AG
Sbjct: 881 GVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAG 933


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  999 bits (2584), Expect = 0.0
 Identities = 575/950 (60%), Positives = 692/950 (72%), Gaps = 84/950 (8%)

Query: 42  VEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ----RA 91
           VEG+AP S+  T++DSP + P   L    S  P    H      G+  G P  Q    R 
Sbjct: 9   VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 68

Query: 92  RLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQ 150
           +LQ ++  LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG  ++R AARTIQ
Sbjct: 69  KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 128

Query: 151 TAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASL-D 209
           TAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE  EK  + +YFEGK  S+ +
Sbjct: 129 TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQVSVTN 187

Query: 210 EGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVKSLAE 268
           +G+  GA              CG   +     S   S +F++ ITELED+FS+QVKSLAE
Sbjct: 188 DGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAE 238

Query: 269 SIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYLDDT- 318
           SID+ALNC  S    E P       R+++ Q           D    S+SD+ LY+D+  
Sbjct: 239 SIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEE 297

Query: 319 ----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSREEGTR 368
               +P  Q+ +R  STE   + R     P++WA A             +ED +  + + 
Sbjct: 298 LSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADTDTSC 345

Query: 369 RGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK 428
           R    LE ++ RLR  HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ  YE       G+ K
Sbjct: 346 RSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPK 405

Query: 429 HKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD 487
           H GP   AP   +  P  E    P PP PL    +S    +G A   R  K E+  + SD
Sbjct: 406 H-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES--DYSD 453

Query: 488 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV 547
           G DN+S+ S+SNSN+TINCSS SSSRDSLRE     L KQTY +E R+SWDSPAF+NDV+
Sbjct: 454 G-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFSNDVI 509

Query: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607
           ++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLGNRQK
Sbjct: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569

Query: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667
           QFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CNP +V
Sbjct: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629

Query: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727
           RQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++L+GI
Sbjct: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689

Query: 728 YQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQLYEVP 777
           Y+RI+ REL+TN+DHVSQVQ VE++IVGKKP          VLSLPHRRLVC C+L+EVP
Sbjct: 690 YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 749

Query: 778 DPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQF 837
           DPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK  VTYSFRQSF L  M + LF+N YY  
Sbjct: 750 DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 809

Query: 838 GIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMM 897
           GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQKG++
Sbjct: 810 GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 869

Query: 898 RPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAG 946
           RP+ SQ     K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AG
Sbjct: 870 RPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAG 919


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  573 bits (1476), Expect = e-163
 Identities = 360/777 (46%), Positives = 457/777 (58%), Gaps = 94/777 (12%)

Query: 131 MLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFE 190
           MLE KYGG  +SRRAA TIQTAFRQY+++KNFE++R+S  ESR+ RRI L          
Sbjct: 1   MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISL---------- 50

Query: 191 EYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYG-GSCGGGIDGGGSSVTTSGEFS 249
              K ++P                 A S   E+ L  G G  G  +    S   T   F+
Sbjct: 51  --RKVRSPT----------------AESLAAEKALMEGYGLVGLPLVRSPSLPPT---FA 89

Query: 250 NDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFS 309
             +TELEDSF++QV+SLA+SID+AL+      M           RES   Q   +  + +
Sbjct: 90  GTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCS--------LRESGAYQLHQALQAAA 141

Query: 310 DLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRR 369
             P         ++  R P +  P  G       A   P  PP  SGT            
Sbjct: 142 GPP-------GLEAEGRAPESAGPGPGDD-----AAETPGLPPAHSGTL----------- 178

Query: 370 GPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKH 429
               +  RD  ++ A+  +        SS  LS  +  G+   Q   E       G  + 
Sbjct: 179 ---MMAFRDVTVQIANQNISV-----SSSTALSVANCLGAQTVQAPAEPAA----GKAEQ 226

Query: 430 KGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCE--------- 480
               GR         APE PA            +    SG A G    K E         
Sbjct: 227 GETSGRE--------APEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETA 278

Query: 481 --AAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWD 538
               G  ++ GD E L SSS S ++    S +S+  S     A  L    Y  E   S  
Sbjct: 279 EVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCK 338

Query: 539 SPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMI 598
           SP  + D +++R YRIGLNLFN  P+KGIQ+LI RGF+ DTP+GVAHF+L+RKGLSRQMI
Sbjct: 339 SPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMI 398

Query: 599 GEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQR 658
           GEFLGN +KQFNRDVLDCVVDEMDFSSM+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQR
Sbjct: 399 GEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQR 458

Query: 659 YCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGED 718
           YC+CNP +V+QF NPDTIFILAFAIILLNTDMYSP++K +RKM L+DFI+NLRGVD+G D
Sbjct: 459 YCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGAD 518

Query: 719 IPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPD 778
           IPR+L+VGIY+RIQ +EL++N+DHV+ V  VE+ IVG K VLS+PHRRLVCC +L+EV D
Sbjct: 519 IPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTD 578

Query: 779 PNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFG 838
            N+ Q+   HQREVFLFNDLLV+ K+  KKK   TY+F +S  L+ M  QLF+N YY  G
Sbjct: 579 VNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHG 638

Query: 839 IKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKG 895
           I L++ + G E+K ++ F A    +  +F  DL+ESIAEV E+E+ R+E ELEKQ+G
Sbjct: 639 ITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQG 695


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  158 bits (399), Expect = 3e-38
 Identities = 91/235 (38%), Positives = 139/235 (59%), Gaps = 9/235 (3%)

Query: 502 ETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNK 561
           ETIN      S +SL    ++G+   +Y  +   + +   F     Q+     G++LFNK
Sbjct: 657 ETIN---RYGSLNSLESTSSSGI--GSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNK 711

Query: 562 KPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEM 621
           KP++GIQYL E+G L  TP  +A F+ + + L    +GEFLG+  K FN++V+   VD+ 
Sbjct: 712 KPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVMYAYVDQH 770

Query: 622 DFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAF 681
           DFS  D   ALR F    R+ GEAQK++RL+E F+ RY  CN      F + DT ++LA+
Sbjct: 771 DFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASADTAYVLAY 829

Query: 682 AIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGREL 736
           +II+L TD++SP VK   KM  + +IK  RG+++ +D+P + L  IY  I G+++
Sbjct: 830 SIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  153 bits (386), Expect = 8e-37
 Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607
           + R   +G   FN  P+KGIQ+L+E   L +TP  +A F+ + +GL++  IG++LG R+ 
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119

Query: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667
           + N  VL   VD  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC+CNP + 
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178

Query: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727
             F++ DT ++L+FA+I+LNT +++P+V+   K  L+ F+   RG++ G D+P +LL  +
Sbjct: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234

Query: 728 YQRIQGRELRTNDD 741
           Y  I+    +  +D
Sbjct: 235 YDSIRNEPFKIPED 248


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  153 bits (386), Expect = 8e-37
 Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607
           + R   +G   FN  P+KGIQ+L+E   L +TP  +A F+ + +GL++  IG++LG R+ 
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119

Query: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667
           + N  VL   VD  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC+CNP + 
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178

Query: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727
             F++ DT ++L+FA+I+LNT +++P+V+   K  L+ F+   RG++ G D+P +LL  +
Sbjct: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234

Query: 728 YQRIQGRELRTNDD 741
           Y  I+    +  +D
Sbjct: 235 YDSIRNEPFKIPED 248


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  147 bits (372), Expect = 4e-35
 Identities = 73/182 (40%), Positives = 119/182 (65%), Gaps = 4/182 (2%)

Query: 555 GLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVL 614
           G+ LFNKKP++GIQ+L E+G L  +   +A F+ + + L    +G+FLG+  + FN++V+
Sbjct: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708

Query: 615 DCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPD 674
              VD++DF   +   ALR F    R+ GEAQK++RL+E F+ RY  CN      F + D
Sbjct: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767

Query: 675 TIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGR 734
           T ++LA++II+L TD++SP VK   KM  + +IK  RG+++ +D+P + L  IY+ I+G+
Sbjct: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825

Query: 735 EL 736
           ++
Sbjct: 826 KI 827


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  147 bits (372), Expect = 4e-35
 Identities = 75/194 (38%), Positives = 125/194 (64%), Gaps = 6/194 (3%)

Query: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607
           + +   +G   FN  P+KGIQ+LIE   L  +P  VA F+ + +GL++ +IG++LG R  
Sbjct: 66  RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124

Query: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+ RYC+CNP + 
Sbjct: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183

Query: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727
             F++ DT ++L+FAII+LNT +++ +V+   K   + FI   RG++ G D+P +LL  +
Sbjct: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVR--DKPTAERFIAMNRGINEGGDLPEELLRNL 239

Query: 728 YQRIQGRELRTNDD 741
           Y+ I+    +  +D
Sbjct: 240 YESIKNEPFKIPED 253


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  147 bits (372), Expect = 4e-35
 Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607
           + +   +G   FN  P+KGIQ+LIE   L +T   +A F+ + +GL++  IG++LG R  
Sbjct: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120

Query: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC CN  + 
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179

Query: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727
             F++ DT ++L+FAII+LNT +++P+VK   K  ++ FI   RG+++G D+P +LL  +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235

Query: 728 YQRIQGRELRTNDD 741
           Y+ I+    +  +D
Sbjct: 236 YESIKNEPFKIPED 249


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  147 bits (372), Expect = 4e-35
 Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607
           + +   +G   FN  P+KGIQ+LIE   L +T   +A F+ + +GL++  IG++LG R  
Sbjct: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120

Query: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC CN  + 
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179

Query: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727
             F++ DT ++L+FAII+LNT +++P+VK   K  ++ FI   RG+++G D+P +LL  +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235

Query: 728 YQRIQGRELRTNDD 741
           Y+ I+    +  +D
Sbjct: 236 YESIKNEPFKIPED 249


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  139 bits (351), Expect = 1e-32
 Identities = 72/188 (38%), Positives = 116/188 (61%), Gaps = 6/188 (3%)

Query: 554 IGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDV 613
           IG   FN  P KGIQY IE   L+     +A F+ + +GL++  IG +LG R    N  V
Sbjct: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP-INLQV 125

Query: 614 LDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP 673
           L   VD  +F++++L  ALR+F    R+ GEAQK++R++EAF+ RYC+CNP +   F++ 
Sbjct: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182

Query: 674 DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQG 733
           DT ++L+F+II+LNT +++P+V+   +   + F+   RG++NG D+P D L  ++  I+ 
Sbjct: 183 DTCYVLSFSIIMLNTSLHNPNVR--DRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240

Query: 734 RELRTNDD 741
                 +D
Sbjct: 241 EPFSIPED 248


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  132 bits (333), Expect = 1e-30
 Identities = 85/246 (34%), Positives = 138/246 (56%), Gaps = 14/246 (5%)

Query: 509 GSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRI---GLNLFNKKPEK 565
           G S    L E   +G  K+  ++  R S   P     +  +   ++   G   FN+KP+K
Sbjct: 657 GKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKK 716

Query: 566 GIQYLIERGFLSDTPVG---VAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMD 622
           GIQ+L E+G L+  P+    VA ++ E   L ++MIGEF+ +R+   N D+L+  V    
Sbjct: 717 GIQFLQEKGLLT-IPMDNTEVAQWLRENPRLDKKMIGEFVSDRK---NIDLLESFVSTFS 772

Query: 623 FSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFA 682
           F  + LD+ALR +    R+ GEA  ++RL+EAF++R+  CN +    F N D  F LA+A
Sbjct: 773 FQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGS---PFANSDACFSLAYA 829

Query: 683 IILLNTDMYSPSV-KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDD 741
           +I+LNTD ++ +V K    M L++F KNL+GV+ G+D  +D+L  +Y  I+  E+   ++
Sbjct: 830 VIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEE 889

Query: 742 HVSQVQ 747
               V+
Sbjct: 890 QTGLVR 895


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score =  107 bits (267), Expect = 5e-23
 Identities = 72/214 (33%), Positives = 116/214 (54%), Gaps = 17/214 (7%)

Query: 523 GLCKQTYQRETRHSWDSP---AFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDT 579
           GLCK T+   + ++ + P   +F    +Q      G   FN  P++G+ Y + +G L D+
Sbjct: 110 GLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDE---GSLTFNANPDEGVNYFMSKGILDDS 166

Query: 580 PVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHI 639
           P  +A FI   + L+ + +  +L  R     RDVLD +V   +F +  L +ALR+F  HI
Sbjct: 167 PKEIAKFIFCTRTLNWKKLRIYLDER-----RDVLDDLVTLHNFRNQFLPNALREFFRHI 221

Query: 640 RVQGE-AQKVERLIEAFSQRYCVCNPALVRQF-RNPDTIFILAFAIILLNTDMYSPSVKA 697
               E  + +E LI  FS R+C CNP L+R+   +PD +++L +++ILL+ D+ SP VK 
Sbjct: 222 HAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVK- 280

Query: 698 ERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRI 731
             KM   +FI+N R     ++I  D +  +Y  I
Sbjct: 281 -NKMSKREFIRNTRRA--AQNISEDFVGHLYDNI 311


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  104 bits (259), Expect = 4e-22
 Identities = 113/433 (26%), Positives = 177/433 (40%), Gaps = 59/433 (13%)

Query: 325 ERLPSTEPPP-QGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPG--CLECRDFRL 381
           E  PS+E PP    P    P PLP   P + SG  ++   E G          E  +   
Sbjct: 316 ESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGAR 375

Query: 382 RAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYE---ADGCS--PHGTLKHKGPPGRA 436
             + +PL +  P    +   +D  D  S   + + E   A G S     +L+    PG  
Sbjct: 376 PGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPT 435

Query: 437 PIPHRHY---PAPEGPAPAPPGPLPPAP---NSGTGPSGVAGGRRLGKCEAAGENSDGGD 490
             P   +   P P  P P PP P P AP   +SGT  +      + G+ E A   +    
Sbjct: 436 QSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAP 495

Query: 491 NESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRR 550
                S  +S +++   +         EPP + L   +              ++++    
Sbjct: 496 GREPPSPCHSEDSLGLGAAPLGS----EPPLSQLVSDS--------------DSELDSTE 537

Query: 551 HYRIG----LNLFNKKPEKGIQYLIERGFLSD--TPVGVAHFILERKGLSRQMIGEFLGN 604
              +G    L+   K   +  Q L +R +  D      VA  + +    S+ + GE+L  
Sbjct: 538 RLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYL-- 595

Query: 605 RQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNP 664
             K F             F+ M LD ALR F   + + GE Q+ ER++  FSQRY  CNP
Sbjct: 596 --KFFV------------FTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNP 641

Query: 665 ALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLL 724
                  + D    L  A++LLNTD++  ++   ++M   DFI NL G+++G D PR+LL
Sbjct: 642 ---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMTCGDFIGNLEGLNDGGDFPRELL 696

Query: 725 VGIYQRIQGRELR 737
             +Y  I+  +L+
Sbjct: 697 KALYSSIKNEKLQ 709



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 46/153 (30%), Positives = 61/153 (39%), Gaps = 23/153 (15%)

Query: 279 SGPMSEEPGSAQ--LEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEP-PPQ 335
           + P ++ P S     E      + + +S TS + L   L    P QSP       P PP 
Sbjct: 392 TSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEA-LASPGPTQSPFFTFELPPQPPA 450

Query: 336 GRPEFWAPAPLPPVPPPVPSGTRED------GSREEGTRR---GPG------CLECRDFR 380
            RP+  APAPL P+ P   + +  D      G  EE   R    PG      C       
Sbjct: 451 PRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG 510

Query: 381 LRAAHL----PLLTIEPPSDSSVDLSDRSDRGS 409
           L AA L    PL  +   SDS +D ++R   GS
Sbjct: 511 LGAAPLGSEPPLSQLVSDSDSELDSTERLALGS 543


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 21/203 (10%)

Query: 576 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF 635
           +S+    +A  +   +G  R  +   LG +  +F+R V    +   DFS + LD ALR F
Sbjct: 310 VSEAAHRLARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTF 368

Query: 636 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV 695
                + GE Q+ ER++  FS+RYC CNP       + D I  L  A++LLNTD++  ++
Sbjct: 369 LKAFPLMGETQERERVLTHFSRRYCQCNP---DDSTSEDGIHTLTCALMLLNTDLHGHNI 425

Query: 696 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELR---------------TND 740
              +KM    FI NL  +++G+D  +DLL  +Y  I+  +L                 +D
Sbjct: 426 --GKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDD 483

Query: 741 DHVSQVQAVERMIVGKKPVLSLP 763
              +  + V R++ G  P L +P
Sbjct: 484 KFGTGTKKVTRILDGGNPFLDVP 506


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)

Query: 595 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 654
           R  + + LG +  +F++ V +  +   DF+ M LD +LR F     + GE Q+ ER++  
Sbjct: 66  RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 124

Query: 655 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 714
           FS RY  CNP  +    + D +  L  AI+LLNTD++  ++   +KM   +FI NL+GV+
Sbjct: 125 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 179

Query: 715 NGEDIPRDLLVGIYQRIQGREL 736
            G D  +DLL  +Y  I+  +L
Sbjct: 180 EGVDFSKDLLKALYNSIKNEKL 201


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)

Query: 595 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 654
           R  + + LG +  +F++ V +  +   DF+ M LD +LR F     + GE Q+ ER++  
Sbjct: 600 RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 658

Query: 655 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 714
           FS RY  CNP  +    + D +  L  AI+LLNTD++  ++   +KM   +FI NL+GV+
Sbjct: 659 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 713

Query: 715 NGEDIPRDLLVGIYQRIQGREL 736
            G D  +DLL  +Y  I+  +L
Sbjct: 714 EGVDFSKDLLKALYNSIKNEKL 735


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 54/177 (30%), Positives = 91/177 (51%), Gaps = 11/177 (6%)

Query: 591 KGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVER 650
           +G  +  +  +L  +   F+R V +  +    F    LD ALR F   + + GE Q+ ER
Sbjct: 599 EGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERER 657

Query: 651 LIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNL 710
           ++  FS+R+  CNP +   F + D++  L  AI+LLNTD++  ++   + M   +FI NL
Sbjct: 658 ILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMSCQEFITNL 712

Query: 711 RGVDNGEDIPRDLLVGIYQRIQGRELR---TNDDHVSQVQAVERMIVGK--KPVLSL 762
            G+ +G + P++LL  +Y  I+  +L      +D     +A   +  GK  KP L L
Sbjct: 713 NGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQL 769


>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
          Length = 1312

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 57/201 (28%), Positives = 77/201 (38%), Gaps = 39/201 (19%)

Query: 281 PMSEEPGSAQLEKRESKEQQEDSSATSFSDLP-----LYLDDTVPQQSPERLPSTEPPPQ 335
           P  EE    + E+ E  E++E+  + S S +      +Y D+++ Q  P       P P 
Sbjct: 267 PEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPG---DESPRPD 323

Query: 336 GRPEFWAPAPLPPVPPPVPSGTREDGSRE----------EGTRRGPGCLECRDFRLRAAH 385
            +P    P P P  PP V S TR DG+            E  R G   +E       A  
Sbjct: 324 AQPT--QPTPAPGTPPQVDS-TRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALP 380

Query: 386 LPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPA 445
            PLL   PP DS ++            ++V   +   P   L    P GRA  P    PA
Sbjct: 381 PPLL---PPGDSEIE----------EGEIVQPEE--EPRLALSLFRPGGRAARPT---PA 422

Query: 446 PEGPAPAPPGPLPPAPNSGTG 466
                 A P P PPAP +  G
Sbjct: 423 ASATPTAQPLPQPPAPRAPEG 443



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 12/26 (46%), Positives = 14/26 (53%)

Query: 436 APIPHRHYPAPEGPAPAPPGPLPPAP 461
           +P P    P+P  P P P  P PPAP
Sbjct: 198 SPSPSSSSPSPPPPPPPPAPPAPPAP 223


>gi|116256464 hypothetical protein LOC343990 [Homo sapiens]
          Length = 962

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 55/212 (25%), Positives = 73/212 (34%), Gaps = 37/212 (17%)

Query: 280 GPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEP--PPQGR 337
           GP +  P       R ++ Q   +   S  +        VP + P   P+T     P+  
Sbjct: 294 GPPAPLPPPGGARARRARLQHSSALTASVEE------GGVPGEDPSSRPATPELAEPESA 347

Query: 338 PEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPG-CLECRDFRLR--------AAHLPL 388
           P      P PP  PP P     DG +++G     G C    D            A+  P 
Sbjct: 348 PTLRVEPPSPPEGPPNPG---PDGGKQDGEAPPAGPCAPATDKAEEVVCAPEDVASPFPT 404

Query: 389 L-----TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRH- 442
                 T  P +D +      S R    R +  EA+   P    + KGPPG AP P R  
Sbjct: 405 AIPEGDTTPPETDPAATSEAPSARDGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPEREA 464

Query: 443 ----------YPAPEGPAPA-PPGPLPPAPNS 463
                      P   G  P+  P P PPAP S
Sbjct: 465 ETEPERGAGTEPERIGTEPSTAPAPSPPAPKS 496



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 67/278 (24%), Positives = 88/278 (31%), Gaps = 56/278 (20%)

Query: 240 SSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQ 299
           S  T S   S++       FS   +S +  +D +   H          S+++ +  S+ Q
Sbjct: 190 SDSTVSARISDNSLAPVADFSYPAES-SSCLDNSAAKHKLQVKPRNQRSSKMRRLSSRAQ 248

Query: 300 QEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFW--------APAPLPPVPP 351
            E     S SDL      T  ++  E  P  E  P+ RP            P P PP P 
Sbjct: 249 SE-----SLSDLTC----TPEEEENEEKPLLEVSPEERPSSGQQDVAPDRGPEPGPPAPL 299

Query: 352 PVPSGTREDGSR-----------EEGTRRG--PGCLECRDFRLRAAHLPLLTIEPPSDSS 398
           P P G R   +R           EEG   G  P               P L +EPPS   
Sbjct: 300 PPPGGARARRARLQHSSALTASVEEGGVPGEDPSSRPATPELAEPESAPTLRVEPPSPPE 359

Query: 399 VDLSDRSDRG-----------------SVHRQLVYEADGCSPHGTLKHKG---PPGRAPI 438
              +   D G                      +    D  SP  T   +G   PP   P 
Sbjct: 360 GPPNPGPDGGKQDGEAPPAGPCAPATDKAEEVVCAPEDVASPFPTAIPEGDTTPPETDPA 419

Query: 439 PHRHYPA----PEGPAPAPPGPLPPA-PNSGTGPSGVA 471
                P+    PE   P    P PP  P+   GP G A
Sbjct: 420 ATSEAPSARDGPERSVPKEAEPTPPVLPDEEKGPPGPA 457


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 44/149 (29%), Positives = 54/149 (36%), Gaps = 42/149 (28%)

Query: 332 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 389
           PPPQG  +P+   P P  P  PP   G +  G    G  +GP                  
Sbjct: 245 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP------------------ 286

Query: 390 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGP 449
              PP   S   S RS  G        +  G  P G  + +GPP   P P +    P+GP
Sbjct: 287 ---PPQGGSKSRSSRSPPG--------KPQGPPPQGGNQPQGPP---PPPGK----PQGP 328

Query: 450 APA----PPGPLPPAPNSGTGPSGVAGGR 474
            P     P GP PP    G  P G +  R
Sbjct: 329 PPQGGNKPQGPPPPGKPQGPPPQGGSKSR 357



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 46/162 (28%), Positives = 57/162 (35%), Gaps = 48/162 (29%)

Query: 320 PQQSPERLPSTEP------PPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGP 371
           PQ    R P + P      PPQG  +P+   P P  P  PP   G +  G    G  +GP
Sbjct: 103 PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP 162

Query: 372 GCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKG 431
                                PP   +   S RS  G        +  G  P G  + +G
Sbjct: 163 ---------------------PPQGDNKSRSSRSPPG--------KPQGPPPQGGNQPQG 193

Query: 432 PPGRAPIPHRHYPAPEGPAP----APPGPLPPAPNSGTGPSG 469
           PP   P P +    P+GP P     P GP PP    G  P G
Sbjct: 194 PP---PPPGK----PQGPPPQGGNKPQGPPPPGKPQGPPPQG 228



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 43/149 (28%), Positives = 54/149 (36%), Gaps = 42/149 (28%)

Query: 332 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 389
           PPPQG  +P+   P P  P  PP   G +  G    G  +GP                  
Sbjct: 183 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP------------------ 224

Query: 390 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGP 449
              PP   +   S RS  G        +  G  P G  + +GPP   P P +    P+GP
Sbjct: 225 ---PPQGDNKSQSARSPPG--------KPQGPPPQGGNQPQGPP---PPPGK----PQGP 266

Query: 450 APA----PPGPLPPAPNSGTGPSGVAGGR 474
            P     P GP PP    G  P G +  R
Sbjct: 267 PPQGGNKPQGPPPPGKPQGPPPQGGSKSR 295



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 41/144 (28%), Positives = 50/144 (34%), Gaps = 43/144 (29%)

Query: 332 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 389
           PPPQG  +P+   P P  P  PP   G +  G    G  +G                   
Sbjct: 60  PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG------------------- 100

Query: 390 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGP 449
              PP       S RS  G        +  G  P G  + +GPP   P P +    P+GP
Sbjct: 101 ---PPPQGDKSRSPRSPPG--------KPQGPPPQGGNQPQGPP---PPPGK----PQGP 142

Query: 450 AP----APPGPLPPAPNSGTGPSG 469
            P     P GP PP    G  P G
Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQG 166



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 39/150 (26%), Positives = 53/150 (35%), Gaps = 11/150 (7%)

Query: 328 PSTEPPPQGRPEFWAPA----PLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRA 383
           P   PPP G+P+   P     P  P PP  P G    G +    R  PG  + +    + 
Sbjct: 68  PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPG--KPQGPPPQG 125

Query: 384 AHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK---HKGPPGRAP-IP 439
            + P     PP           ++         +  G  P G  K    + PPG+    P
Sbjct: 126 GNQPQGPPPPPGKPQGPPPQGGNKPQ-GPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPP 184

Query: 440 HRHYPAPEGPAPAPPGPLPPAPNSGTGPSG 469
            +    P+GP P P  P  P P  G  P G
Sbjct: 185 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 214



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 51/201 (25%), Positives = 71/201 (35%), Gaps = 21/201 (10%)

Query: 278 PSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGR 337
           P GP    PG     K +    Q D+ + S    P       PQ   +  P   PPP G+
Sbjct: 150 PQGP--PPPG-----KPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQ--PQGPPPPPGK 200

Query: 338 PEFWAPA----PLPPVPPPVPSGTREDG-SREEGTRRGPGCLECRDFRLRAAHLPLLTIE 392
           P+   P     P  P PP  P G    G ++ +  R  PG  + +    +  + P     
Sbjct: 201 PQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPG--KPQGPPPQGGNQPQGPPP 258

Query: 393 PPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK---HKGPPGRAP-IPHRHYPAPEG 448
           PP           ++         +  G  P G  K    + PPG+    P +    P+G
Sbjct: 259 PPGKPQGPPPQGGNKPQ-GPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQG 317

Query: 449 PAPAPPGPLPPAPNSGTGPSG 469
           P P P  P  P P  G  P G
Sbjct: 318 PPPPPGKPQGPPPQGGNKPQG 338



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 39/134 (29%), Positives = 48/134 (35%), Gaps = 30/134 (22%)

Query: 332 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 389
           PPPQG  +P+   P P  P  PP   G +  G    G  +GP                  
Sbjct: 307 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP------------------ 348

Query: 390 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPA--PE 447
              PP   S   S RS  G    Q   + +G +P G      P G  P   +  PA  P+
Sbjct: 349 ---PPQGGSKSRSARSPPGK--PQGPPQQEGNNPQGP---PPPAGGNPQQPQAPPAGQPQ 400

Query: 448 GPAPAPPGPLPPAP 461
           GP   P G  P  P
Sbjct: 401 GPPRPPQGGRPSRP 414



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 20/54 (37%), Positives = 22/54 (40%), Gaps = 4/54 (7%)

Query: 420 GCSPHGTLKHKGPPGRAPIPHRHYPA----PEGPAPAPPGPLPPAPNSGTGPSG 469
           G  P G  K +GPP     P    P     P+GP P P  P  P P  G  P G
Sbjct: 38  GAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 91



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 18/50 (36%), Positives = 22/50 (44%), Gaps = 5/50 (10%)

Query: 328 PSTEPPPQGRPEFWAPA----PLPPVPPPVPSG-TREDGSREEGTRRGPG 372
           P   PPP G+P+   P     P  P PP  P G   + GS+    R  PG
Sbjct: 315 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPG 364


>gi|239749251 PREDICTED: similar to hCG2042508 [Homo sapiens]
          Length = 460

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 51/180 (28%), Positives = 67/180 (37%), Gaps = 6/180 (3%)

Query: 347 PPVPPPVPSGTREDGSR--EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDR 404
           PP+P P     R   +R    GT +     +CR   LR   L  L +E P     +L + 
Sbjct: 105 PPLPHPGDHHPRHRKNRGPSAGTSQLGKKTQCRSLFLRTKGLCALLLELPPRPPPNLQEG 164

Query: 405 SDRGSVHRQLVYEADGCSPHGTLKHKG--PPGRAPIPHRHY-PAPEGPAPAPPGPLPPAP 461
             R    R  VY  +  +P       G  P  + P+P     PAP+ P P  P   PPA 
Sbjct: 165 GQRAIFQRPPVYLGNKPTPPRQEGSFGGRPKSQPPLPQETAAPAPQ-PGPTAPPARPPAY 223

Query: 462 NSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPA 521
            S  GP G A  R  G  + A     G  +     +    E     S +  R   REP A
Sbjct: 224 ESREGPRGRAESRGSGPAQPAHLPLPGPAHSPAPPAPELREGRAPGSTAGRRPRPREPQA 283



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 12/104 (11%)

Query: 290 QLEKRESKEQQEDSSATSFSDLPLYLDD--TVPQQSPE--RLPSTEPPPQGRPEFWAPAP 345
           +L  R     QE      F   P+YL +  T P+Q       P ++PP        AP P
Sbjct: 152 ELPPRPPPNLQEGGQRAIFQRPPVYLGNKPTPPRQEGSFGGRPKSQPPLPQETAAPAPQP 211

Query: 346 LPPVPPP-VPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPL 388
            P  PP   P+    +G R     RG G         + AHLPL
Sbjct: 212 GPTAPPARPPAYESREGPRGRAESRGSG-------PAQPAHLPL 248


>gi|239743343 PREDICTED: similar to hCG2042508 [Homo sapiens]
          Length = 460

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 51/180 (28%), Positives = 67/180 (37%), Gaps = 6/180 (3%)

Query: 347 PPVPPPVPSGTREDGSR--EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDR 404
           PP+P P     R   +R    GT +     +CR   LR   L  L +E P     +L + 
Sbjct: 105 PPLPHPGDHHPRHRKNRGPSAGTSQLGKKTQCRSLFLRTKGLCALLLELPPRPPPNLQEG 164

Query: 405 SDRGSVHRQLVYEADGCSPHGTLKHKG--PPGRAPIPHRHY-PAPEGPAPAPPGPLPPAP 461
             R    R  VY  +  +P       G  P  + P+P     PAP+ P P  P   PPA 
Sbjct: 165 GQRAIFQRPPVYLGNKPTPPRQEGSFGGRPKSQPPLPQETAAPAPQ-PGPTAPPARPPAY 223

Query: 462 NSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPA 521
            S  GP G A  R  G  + A     G  +     +    E     S +  R   REP A
Sbjct: 224 ESREGPRGRAESRGSGPAQPAHLPLPGPAHSPAPPAPELREGRAPGSTAGRRPRPREPQA 283



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 12/104 (11%)

Query: 290 QLEKRESKEQQEDSSATSFSDLPLYLDD--TVPQQSPE--RLPSTEPPPQGRPEFWAPAP 345
           +L  R     QE      F   P+YL +  T P+Q       P ++PP        AP P
Sbjct: 152 ELPPRPPPNLQEGGQRAIFQRPPVYLGNKPTPPRQEGSFGGRPKSQPPLPQETAAPAPQP 211

Query: 346 LPPVPPP-VPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPL 388
            P  PP   P+    +G R     RG G         + AHLPL
Sbjct: 212 GPTAPPARPPAYESREGPRGRAESRGSG-------PAQPAHLPL 248


>gi|239509031 PREDICTED: similar to hCG2042508 [Homo sapiens]
          Length = 460

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 51/180 (28%), Positives = 67/180 (37%), Gaps = 6/180 (3%)

Query: 347 PPVPPPVPSGTREDGSR--EEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDR 404
           PP+P P     R   +R    GT +     +CR   LR   L  L +E P     +L + 
Sbjct: 105 PPLPHPGDHHPRHRKNRGPSAGTSQLGKKTQCRSLFLRTKGLCALLLELPPRPPPNLQEG 164

Query: 405 SDRGSVHRQLVYEADGCSPHGTLKHKG--PPGRAPIPHRHY-PAPEGPAPAPPGPLPPAP 461
             R    R  VY  +  +P       G  P  + P+P     PAP+ P P  P   PPA 
Sbjct: 165 GQRAIFQRPPVYLGNKPTPPRQEGSFGGRPKSQPPLPQETAAPAPQ-PGPTAPPARPPAY 223

Query: 462 NSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPA 521
            S  GP G A  R  G  + A     G  +     +    E     S +  R   REP A
Sbjct: 224 ESREGPRGRAESRGSGPAQPAHLPLPGPAHSPAPPAPELREGRAPGSTAGRRPRPREPQA 283



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 12/104 (11%)

Query: 290 QLEKRESKEQQEDSSATSFSDLPLYLDD--TVPQQSPE--RLPSTEPPPQGRPEFWAPAP 345
           +L  R     QE      F   P+YL +  T P+Q       P ++PP        AP P
Sbjct: 152 ELPPRPPPNLQEGGQRAIFQRPPVYLGNKPTPPRQEGSFGGRPKSQPPLPQETAAPAPQP 211

Query: 346 LPPVPPP-VPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPL 388
            P  PP   P+    +G R     RG G         + AHLPL
Sbjct: 212 GPTAPPARPPAYESREGPRGRAESRGSG-------PAQPAHLPL 248


>gi|47271406 bin3, bicoid-interacting 3 [Homo sapiens]
          Length = 689

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 44/156 (28%), Positives = 53/156 (33%), Gaps = 21/156 (13%)

Query: 340 FWAPAPLPPV---------PPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLT 390
           F  PAP PP+         P   P      G    GT RGPG   C      +A  P   
Sbjct: 11  FLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERGPG--RCAP----SAGSPAAA 64

Query: 391 IEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPA 450
           +   S  +   S    +   HR    +A     HG  +   PPGRA  P        G  
Sbjct: 65  VGRESPGAAATSSSGPQAQQHRGGGPQAQS---HGEARLSDPPGRAAPPDVGEERRGGGG 121

Query: 451 PAPPGPLPPAPNSGTGPS---GVAGGRRLGKCEAAG 483
                P PP P +G  P    G  GG+R   C   G
Sbjct: 122 TELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGG 157


>gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Homo
           sapiens]
          Length = 247

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 47/154 (30%), Positives = 58/154 (37%), Gaps = 30/154 (19%)

Query: 320 PQQSPERLPSTEPPPQGRPEFWAPAPLPPVPP-PVPSGTREDGSREEGTRRGPGCLECRD 378
           P   PER     PPPQG  +   P P P  P  P P G    G++ +G    PG  E   
Sbjct: 116 PPGKPER-----PPPQGGNQSHRPPPPPGKPERPPPQG----GNQSQGPPPHPGKPEG-- 164

Query: 379 FRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVH---RQLVYEADGCSPHGTLKHKGPPGR 435
                         PP + +   S RS  G      +Q   +  G  P G  +   P G 
Sbjct: 165 -------------PPPQEGNKSRSARSPPGKPQGPPQQEGNKPQGPPPPGKPQGPPPAGG 211

Query: 436 APIPHRHYPA--PEGPAPAPPGPLPPAPNSGTGP 467
            P   +  PA  P+GP P P G  PP P  G  P
Sbjct: 212 NPQQPQAPPAGKPQGPPPPPQGGRPPRPAQGQQP 245



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 40/153 (26%), Positives = 51/153 (33%), Gaps = 28/153 (18%)

Query: 334 PQGR-PEFWAPAPLPPVPPPVPSG-TREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTI 391
           P+GR P+       PP PP  P G   + G++ +G    PG  E R              
Sbjct: 36  PEGRRPQGGNQPQRPPPPPGKPQGPPPQGGNQSQGPPPPPGKPEGR-------------- 81

Query: 392 EPPSDSSVDLSDRSDRGSVHR---QLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEG 448
            PP   +         G   R   Q   ++ G  P      + PP      HR  P P  
Sbjct: 82  -PPQGGNQSQGPPPHPGKPERPPPQGGNQSQGTPPPPGKPERPPPQGGNQSHRPPPPPGK 140

Query: 449 PAPAPP-------GPLPPAPNSGTGPSGVAGGR 474
           P   PP       GP PP P    GP    G +
Sbjct: 141 PERPPPQGGNQSQGP-PPHPGKPEGPPPQEGNK 172


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 95/455 (20%), Positives = 144/455 (31%), Gaps = 86/455 (18%)

Query: 32   TPSGRLAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRA 91
            +P   +A S+V    P +  + AV+  G++ P  L+ L  + S  G PP     P + R 
Sbjct: 2272 SPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGS--GTPPTAANYPSSSRT 2329

Query: 92   RLQPASV-----------------------ALRKQEEEEIKRSKALSDSYELSTDLQDKK 128
               PAS                        AL        + + ALS +   S  +    
Sbjct: 2330 PQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSA 2389

Query: 129  VEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFS 188
             E +  +     L R  +RT  +A  Q RM       R+ +  SRM +     +  +   
Sbjct: 2390 YERVSGRTSPPLLDRARSRTPPSAPSQSRMTSE----RAPSPSSRMGQA---PSQSLLPP 2442

Query: 189  FEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEF 248
             ++  ++  P+ F  +   L       A S  L  G     +   G   G  SV   G  
Sbjct: 2443 AQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVP 2502

Query: 249  SNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSF 308
             +D+ E   S   Q  S   ++  A     S   S    S+      S       S++S 
Sbjct: 2503 HSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSD 2562

Query: 309  SD---LPLYLDDTVPQQSPERLPSTEPPP-----QGRPEFWAPAPLPPVPPPVPSGTRED 360
            S+   LP+      P+ + +R+PS  P P     +GRP           P P P+  +  
Sbjct: 2563 SEGSSLPVQ-----PEVALKRVPSPTPAPKEAVREGRP-----------PEPTPAKRKRR 2606

Query: 361  GSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADG 420
             S                                S SS   S  S   S        +  
Sbjct: 2607 SSSSS-----------------------------SSSSSSSSSSSSSSSSSSSSSSSSSS 2637

Query: 421  CSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG 455
             S   +     P    P P    P P  P   PPG
Sbjct: 2638 SSSSSSSSSSSPSPAKPGPQA-LPKPASPKKPPPG 2671



 Score = 34.3 bits (77), Expect = 0.57
 Identities = 25/70 (35%), Positives = 33/70 (47%), Gaps = 6/70 (8%)

Query: 449  PAPAPPGP---LPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETIN 505
            PAP  P      PPA      PS +A    L   +    +S    + S  SSS+S+ + +
Sbjct: 2497 PAPGVPHSDVGEPPASTGAQQPSALAA---LQPAKERRSSSSSSSSSSSSSSSSSSSSSS 2553

Query: 506  CSSGSSSRDS 515
             SSGSSS DS
Sbjct: 2554 SSSGSSSSDS 2563



 Score = 33.9 bits (76), Expect = 0.74
 Identities = 81/398 (20%), Positives = 138/398 (34%), Gaps = 69/398 (17%)

Query: 2   EPPGRSSRSTASHTLHQYCCPTQVLDSMKLTPSGRLAESSVEGDA-PGSDLSTAVDSPGS 60
           E PG+    T +H L +         + +L  +  +++S V+G +      +     P  
Sbjct: 110 ETPGQRPAVTETHQLAEL----NEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAP 165

Query: 61  QPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYEL 120
           +PP   S +  SSS     P                     KQ++++ K+ +      E 
Sbjct: 166 EPPKPYSLVRESSSSRSPTP---------------------KQKKKKKKKDRGRRS--ES 202

Query: 121 STDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRS-SASESRMSRRII 179
           S+  +++K    ++K+     S++      T  +  R +K+ +R RS S + +  SRR  
Sbjct: 203 SSPRRERKKSSKKKKHRSESESKKRKHRSPTP-KSKRKSKDKKRKRSRSTTPAPKSRRAH 261

Query: 180 LSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGG 239
            S      S  +  ++++ +              A A++H             G    G 
Sbjct: 262 RSTSADSASSSDTSRSRSRS--------------AAAKTHTTALAGRSPSPASGRRGEGD 307

Query: 240 SSVTTSGEFSNDITELEDSFSKQVKSLAESIDE------ALNCHPSGPMS----EEPGSA 289
           +  +  G  S       ++ +KQ  S  E  D+      A    PS   S    E P   
Sbjct: 308 APFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPT 367

Query: 290 QLEKRESKEQQEDSSATSFSDLPLY-------LDDTVPQQSPERLP----STEPPPQGRP 338
            L         +  + T  S  P+          D  P +SPE+LP    S   PP  +P
Sbjct: 368 PLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQP 427

Query: 339 ----EFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPG 372
                  + +P  P P P P   RE  S      R  G
Sbjct: 428 TKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHG 465



 Score = 33.9 bits (76), Expect = 0.74
 Identities = 59/256 (23%), Positives = 83/256 (32%), Gaps = 44/256 (17%)

Query: 278  PSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYL-DDTVPQQSPERLPS----TEP 332
            PS  M + P  + L    +++Q      ++FSD    L   T P    + L S    T  
Sbjct: 2427 PSSRMGQAPSQSLLPP--AQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTT 2484

Query: 333  PPQGRPEFWAPAPLPPVP------PPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHL 386
               G        P P VP      PP  +G ++           P  L        AA  
Sbjct: 2485 SSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQ-----------PSAL--------AALQ 2525

Query: 387  PLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPI-PHRHYPA 445
            P       S SS   S  S   S        +   S  G+          P+ P      
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSS-------SSSSSSSSGSSSSDSEGSSLPVQPEVALKR 2578

Query: 446  PEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETIN 505
               P PAP      A   G  P      R+     ++  +S    + S  SSS+S+ + +
Sbjct: 2579 VPSPTPAPK----EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2634

Query: 506  CSSGSSSRDSLREPPA 521
             SS SSS  S    P+
Sbjct: 2635 SSSSSSSSSSSSSSPS 2650


>gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein [Homo
            sapiens]
          Length = 1650

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 54/180 (30%), Positives = 69/180 (38%), Gaps = 37/180 (20%)

Query: 334  PQGRPEFWAPAPLP-PVPPPVPSGTREDGSREE-------GTRRGPGCLECRDFRLRAAH 385
            P GR     P  LP P  PP  +G  EDG + E       GT+   G     +       
Sbjct: 972  PTGRDGVQGPVGLPGPAGPPGVAG--EDGDKGEVGDPGQKGTKGNKG-----EHGPPGPP 1024

Query: 386  LPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPA 445
             P+  +  P  +  D     + G+   Q  + A G    GT    GPPG  PI  +  P 
Sbjct: 1025 GPIGPVGQPGAAGAD----GEPGARGPQGHFGAKG--DEGTRGFNGPPG--PIGLQGLPG 1076

Query: 446  PEGPA-----------PAPPGPLPPA-PNSGTGPSGVAGGRRLGKCEAAGENSDGGDNES 493
            P G             P PPGP  PA PN   GP G  GG  +G     GE  + G++ S
Sbjct: 1077 PSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGG--VGNLGPPGEKGEPGESGS 1134



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 42/140 (30%), Positives = 49/140 (35%), Gaps = 35/140 (25%)

Query: 335  QGRPEFWAPAPLP-PVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEP 393
            QGRP     A  P PV PP   G R D   + G +  PG +                I P
Sbjct: 1291 QGRPGATGQAGPPGPVGPPGLPGLRGDAGAK-GEKGHPGLIGL--------------IGP 1335

Query: 394  PSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAP 453
            P +      ++ DRG              P G+   KG  G   IP    P   G  P  
Sbjct: 1336 PGEQG----EKGDRGLP-----------GPQGSPGQKGEMG---IPGASGPIGPGGPPGL 1377

Query: 454  PGPLPPAPNSG-TGPSGVAG 472
            PGP  P    G TGP G  G
Sbjct: 1378 PGPAGPKGAKGATGPGGPKG 1397



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 5/50 (10%)

Query: 423 PHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAG 472
           PHG    KGP G+  +P    P  +GP   P    PP      GPSG  G
Sbjct: 582 PHG---EKGPQGKPGLPGM--PGSDGPPGHPGKEGPPGTKGNQGPSGPQG 626



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 24/69 (34%), Positives = 29/69 (42%), Gaps = 19/69 (27%)

Query: 431  GPPGRAPIPHRHYPAPEGP--------APAPPGPLPPAPNSGT-GPSGVAGGRRLGKCEA 481
            GPPGR        P P+GP         P   GP+ P    G  GP G+ G    G    
Sbjct: 944  GPPGR--------PGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPG--PAGPPGV 993

Query: 482  AGENSDGGD 490
            AGE+ D G+
Sbjct: 994  AGEDGDKGE 1002



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 23/85 (27%)

Query: 420 GCSPHGTLKHKGPPGRAPIP----HRHYPAPEGPAPAPPGP--LPPAP--------NSGT 465
           G  PHG      PPG   +P       +P P+GP P PPG   LP  P           T
Sbjct: 780 GDGPHG------PPGERGLPGPQGPNGFPGPKGP-PGPPGKDGLPGHPGQRGEVGFQGKT 832

Query: 466 GPSGVAGGRRLGKCEAAGENSDGGD 490
           GP G  G   +G   AAGE    G+
Sbjct: 833 GPPGPPG--VVGPQGAAGETGPMGE 855



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 29/96 (30%), Positives = 35/96 (36%), Gaps = 22/96 (22%)

Query: 393 PPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPG-RAPIPHRHYPAPEGPA- 450
           PP +      +R D G +  + +    G  P G L  KGPPG   P   R    P+GP  
Sbjct: 498 PPGEDG----ERGDDGEIGPRGLPGESG--PRGLLGPKGPPGIPGPPGVRGMDGPQGPKG 551

Query: 451 -------PAPPGPLP-------PAPNSGTGPSGVAG 472
                  P PPG          P P    GP G  G
Sbjct: 552 SLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKG 587



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 23/62 (37%), Positives = 23/62 (37%), Gaps = 1/62 (1%)

Query: 412 RQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG-PLPPAPNSGTGPSGV 470
           R L   A G    G     GPPG A  P     A  G    PPG P P  P    G  GV
Sbjct: 904 RGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGV 963

Query: 471 AG 472
            G
Sbjct: 964 PG 965



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 68/283 (24%), Positives = 96/283 (33%), Gaps = 51/283 (18%)

Query: 239 GSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEA-LNCHPSGPMSEEPGSAQLEKRESK 297
           G+ +     F  D+ EL  +    V++  ES ++  L C   G   E P + Q  + +  
Sbjct: 192 GARILDEEVFEGDVQEL--AIVPGVQAAYESCEQKELECE--GGQRERPQNQQPHRAQRS 247

Query: 298 EQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPP--------------QGRPEFWAP 343
            QQ+ S      +      D  P +  E L S+  PP              +G P    P
Sbjct: 248 PQQQPSRLHRPQNQEPQSQDPTPGEEEEILESSLLPPLEEAAHGPRGLKGEKGEPAVLEP 307

Query: 344 APLPPVPPPV--------PSGTREDGSR--EEGTRRGPGCLECRDFRLRAAHLPLLTIEP 393
             L   PP          P G + +     + G R  PG           A LP     P
Sbjct: 308 GMLVEGPPGPEGPAGLIGPPGIQGNPGPVGDPGERGPPG----------RAGLPGSDGAP 357

Query: 394 -PSDSSVDLSDR-----SDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPE 447
            P  +S+ L  R      D+G V      +A        L  +GPPG  P+ +   P P 
Sbjct: 358 GPPGTSLMLPFRFGSGGGDKGPVVAAQEAQAQAILQQARLALRGPPG--PMGYTGRPGPL 415

Query: 448 GPAPAPPGPLPPAPNSGTGPSGVAGGRRL-GKCEAAGENSDGG 489
           G    P  P     +   GP G  G + L G    AG     G
Sbjct: 416 GQ---PGSPGLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAG 455


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,740,710
Number of Sequences: 37866
Number of extensions: 2535402
Number of successful extensions: 27239
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 219
Number of HSP's successfully gapped in prelim test: 776
Number of HSP's that attempted gapping in prelim test: 17482
Number of HSP's gapped (non-prelim): 7837
length of query: 949
length of database: 18,247,518
effective HSP length: 112
effective length of query: 837
effective length of database: 14,006,526
effective search space: 11723462262
effective search space used: 11723462262
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.