BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|53832024 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta isoform b [Homo sapiens] (618 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|53832024 nuclear factor of kappa light polypeptide gene enhan... 1244 0.0 gi|13899229 nuclear factor of kappa light polypeptide gene enhan... 1244 0.0 gi|41281709 nuclear factor of kappa light polypeptide gene enhan... 206 7e-53 gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] 113 6e-25 gi|117320531 nuclear factor of kappa light polypeptide gene enha... 101 2e-21 gi|117320540 nuclear factor of kappa light polypeptide gene enha... 101 2e-21 gi|117320527 nuclear factor of kappa light polypeptide gene enha... 101 2e-21 gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 94 3e-19 gi|71274109 nuclear factor of kappa light polypeptide gene enhan... 91 3e-18 gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 89 9e-18 gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 82 2e-15 gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 82 2e-15 gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 82 2e-15 gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 82 2e-15 gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 82 2e-15 gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 79 1e-14 gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 79 1e-14 gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 79 1e-14 gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 77 5e-14 gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 76 8e-14 gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 75 1e-13 gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 74 3e-13 gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 72 1e-12 gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 71 3e-12 gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 71 3e-12 gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 69 1e-11 gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 69 1e-11 gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 68 3e-11 gi|89363047 death-associated protein kinase 1 [Homo sapiens] 67 4e-11 gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 67 5e-11 >gi|53832024 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta isoform b [Homo sapiens] Length = 618 Score = 1244 bits (3219), Expect = 0.0 Identities = 618/618 (100%), Positives = 618/618 (100%) Query: 1 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 60 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS Sbjct: 1 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 60 Query: 61 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 120 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI Sbjct: 61 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 120 Query: 121 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 180 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM Sbjct: 121 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 180 Query: 181 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 240 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL Sbjct: 181 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 240 Query: 241 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 300 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP Sbjct: 241 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 300 Query: 301 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 360 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS Sbjct: 301 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 360 Query: 361 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 420 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC Sbjct: 361 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 420 Query: 421 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 480 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE Sbjct: 421 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 480 Query: 481 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 540 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS Sbjct: 481 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 540 Query: 541 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE Sbjct: 541 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600 Query: 601 QIRRILKGKSIQQRAPPY 618 QIRRILKGKSIQQRAPPY Sbjct: 601 QIRRILKGKSIQQRAPPY 618 >gi|13899229 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta isoform a [Homo sapiens] Length = 718 Score = 1244 bits (3219), Expect = 0.0 Identities = 618/618 (100%), Positives = 618/618 (100%) Query: 1 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 60 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS Sbjct: 101 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 160 Query: 61 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 120 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI Sbjct: 161 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 220 Query: 121 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 180 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM Sbjct: 221 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 280 Query: 181 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 240 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL Sbjct: 281 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 340 Query: 241 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 300 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP Sbjct: 341 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 400 Query: 301 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 360 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS Sbjct: 401 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 460 Query: 361 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 420 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC Sbjct: 461 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 520 Query: 421 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 480 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE Sbjct: 521 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 580 Query: 481 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 540 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS Sbjct: 581 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 640 Query: 541 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE Sbjct: 641 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700 Query: 601 QIRRILKGKSIQQRAPPY 618 QIRRILKGKSIQQRAPPY Sbjct: 701 QIRRILKGKSIQQRAPPY 718 >gi|41281709 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta [Homo sapiens] Length = 313 Score = 206 bits (523), Expect = 7e-53 Identities = 126/298 (42%), Positives = 178/298 (59%), Gaps = 17/298 (5%) Query: 322 VEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQ 381 +E + + + Q L++D +GDT LH+ A+G R +Y A + LDI+EH G+ Sbjct: 27 LEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGK 86 Query: 382 SAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQ 441 + VA AANQ LIV+DL+N+GA+ N D GR+ LHV A G VL A+ + S Sbjct: 87 TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV----LNSGV 142 Query: 442 FVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM 501 VDLEA +++GLTPLH A++A N + +P + L + + +D + L+QM Sbjct: 143 QVDLEARDFEGLTPLHTAILALNVAM-------RPSDLCPRVLSTQARDRLDCVHMLLQM 195 Query: 502 GAAVEAKDRKSGRTALHLAAEEANLELIRLFLELP--SCLSFVNAKAYNGNTALHVAASL 559 GA +++ KS +T LHLA + AN L++L LELP +FVN KA+ GNTALH+AA+L Sbjct: 196 GANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAAL 254 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPP 617 Q VR L+ GADP+ RNLENEQPVHL+ GP E +R++LK + APP Sbjct: 255 PPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRV---APP 309 >gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] Length = 454 Score = 113 bits (282), Expect = 6e-25 Identities = 97/312 (31%), Positives = 140/312 (44%), Gaps = 43/312 (13%) Query: 300 PFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRAL 359 P MG+P L L+ E A+I+ D DGDT LHIAV QG Sbjct: 93 PTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMAT--RADEDGDTPLHIAVVQGNLPA 150 Query: 360 SYVLARKMN-ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLH 418 + L LDI + Q+ +AV +V+ LV GA D G+T H Sbjct: 151 VHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAH 210 Query: 419 VCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHS 478 + E L+A+ A +DLEA NYDGLT LH AV Sbjct: 211 LACEHRSPTCLRALLDSAAPGT--LDLEARNYDGLTALHVAV------------------ 250 Query: 479 PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSC 538 N +T++ L++ GA ++A D KSGR+ L A E +L +++L L+ Sbjct: 251 ---------NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHG-- 299 Query: 539 LSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPV 598 + VNA+ Y+G++ALH A+ L VR L+R GAD S +N N+ P+ + Sbjct: 300 -ANVNAQMYSGSSALHSASGRGL----LPLVRTLVRSGADSSLKNCHNDTPLMVAR---- 350 Query: 599 GEQIRRILKGKS 610 ++ IL+GK+ Sbjct: 351 SRRVIDILRGKA 362 >gi|117320531 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform a [Homo sapiens] Length = 900 Score = 101 bits (251), Expect = 2e-21 Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%) Query: 315 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 370 ++L + V + L + ++D +GDT LH+A+ G+ + + YV+ + L Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517 Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 428 ++++ H Q+ +AV Q +V L+ +GA D G + +H+ A G ++ Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577 Query: 429 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 487 L+A+ Q GA Q L +++GL P+H AV A SPE +LL Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619 Query: 488 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 547 + GA VEA +R+ GRTALHLA E L L+ + + VNA+ + Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666 Query: 548 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600 GNT LH+AA L Y RLL++ GAD + ENE+P+ +P P + Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712 >gi|117320540 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform b [Homo sapiens] Length = 899 Score = 101 bits (251), Expect = 2e-21 Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%) Query: 315 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 370 ++L + V + L + ++D +GDT LH+A+ G+ + + YV+ + L Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517 Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 428 ++++ H Q+ +AV Q +V L+ +GA D G + +H+ A G ++ Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577 Query: 429 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 487 L+A+ Q GA Q L +++GL P+H AV A SPE +LL Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619 Query: 488 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 547 + GA VEA +R+ GRTALHLA E L L+ + + VNA+ + Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666 Query: 548 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600 GNT LH+AA L Y RLL++ GAD + ENE+P+ +P P + Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712 >gi|117320527 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform b [Homo sapiens] Length = 899 Score = 101 bits (251), Expect = 2e-21 Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%) Query: 315 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 370 ++L + V + L + ++D +GDT LH+A+ G+ + + YV+ + L Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517 Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 428 ++++ H Q+ +AV Q +V L+ +GA D G + +H+ A G ++ Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577 Query: 429 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 487 L+A+ Q GA Q L +++GL P+H AV A SPE +LL Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619 Query: 488 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 547 + GA VEA +R+ GRTALHLA E L L+ + + VNA+ + Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666 Query: 548 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600 GNT LH+AA L Y RLL++ GAD + ENE+P+ +P P + Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712 >gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] Length = 969 Score = 94.4 bits (233), Expect = 3e-19 Identities = 77/273 (28%), Positives = 128/273 (46%), Gaps = 39/273 (14%) Query: 316 SLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNAL---HM 372 +LF + V + L + + +D +GD+ LH+A+ L L + L + Sbjct: 516 ALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDI 575 Query: 373 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 432 ++++ Q+ +AV Q +V+DL+ GA ++ D G + LH+ A++GH +VL + Sbjct: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635 Query: 433 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 492 K + + L+ N DGL +H A+++++ + Sbjct: 636 LKHKKAA---LLLDHPNGDGLNAIHLAMMSNS---------------------------L 665 Query: 493 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 552 + L+ GA V A+++KSGRTALHLA E N+ L L + V++ Y+G T Sbjct: 666 PCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGD--AHVDSTTYDGTTP 723 Query: 553 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLE 585 LH+AA T+L A LL GADP N E Sbjct: 724 LHIAAG--RGSTRLAA--LLKAAGADPLVENFE 752 Score = 36.2 bits (82), Expect = 0.092 Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 7/118 (5%) Query: 495 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCL---SFVNAKAYNGNT 551 +K L+ + + A ++G + LHLA + +L+R LE+ S L +N + T Sbjct: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585 Query: 552 ALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGK 609 LH+A + Q D V L+R GAD S + +HL + + +LK K Sbjct: 586 PLHLAVITK----QEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK 639 >gi|71274109 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon [Homo sapiens] Length = 500 Score = 90.9 bits (224), Expect = 3e-18 Identities = 80/260 (30%), Positives = 122/260 (46%), Gaps = 39/260 (15%) Query: 343 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402 DGDT +H+AV A+ + + +LDI+ + Q+A +AV +Q V+ LV Sbjct: 258 DGDTLVHLAVIHEAPAV-LLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316 Query: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAV----GSNQFVDLEATNYDGLTPLHC 458 GA D G T LHV ++ H + + +G G++ +DL+ N+ GL LH Sbjct: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376 Query: 459 AVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALH 518 A LQ+NQ + ELLL+N GA ++ ++ SG+TALH Sbjct: 377 AT---------LQKNQP-----LMELLLRN-------------GADIDVQEGTSGKTALH 409 Query: 519 LAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGAD 578 LA E L++ L+ + V+A+ NG T LH+AA + L + GAD Sbjct: 410 LAVETQERGLVQFLLQAG---AQVDARMLNGCTPLHLAAGRGL----MGISSTLCKAGAD 462 Query: 579 PSTRNLENEQPVHLVPDGPV 598 RN+E+E P L + V Sbjct: 463 SLLRNVEDETPQDLTEESLV 482 >gi|10092619 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Homo sapiens] Length = 317 Score = 89.4 bits (220), Expect = 9e-18 Identities = 76/283 (26%), Positives = 131/283 (46%), Gaps = 39/283 (13%) Query: 312 QLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNA-L 370 Q+ K L + ++E +E + Q L++D GD+FLH+A+ +AL+ + R++ L Sbjct: 44 QMVKELQEIRLEPQEVPRGSEPWKQQLTED--GDSFLHLAIIHEEKALTMEVIRQVKGDL 101 Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 430 L+ + + Q+ +AV NQ I + L+ G D G TPLH+ E+G + Sbjct: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161 Query: 431 AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKS 490 + + + L+ATNY+G T LH A I Sbjct: 162 VLTQSCTTPHLHSILKATNYNGHTCLHLASI---------------------------HG 194 Query: 491 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 550 + ++ L+ +GA V A++ +GRTALHLA + N +L+ L L+ C + VN Y G Sbjct: 195 YLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK---CGADVNRVTYQGY 251 Query: 551 TALHV-----AASLQYRLTQLDAVRL-LMRKGADPSTRNLENE 587 + + + +Q +L QL L ++ + D + + E+E Sbjct: 252 SPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESE 294 Score = 30.8 bits (68), Expect = 3.9 Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 11/86 (12%) Query: 511 KSGRTALHLAA----EEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQL 566 + G + LHLA + +E+IR ++ L+F+N + T LH+A Q Sbjct: 72 EDGDSFLHLAIIHEEKALTMEVIR---QVKGDLAFLNFQNNLQQTPLHLAVITN----QP 124 Query: 567 DAVRLLMRKGADPSTRNLENEQPVHL 592 + L+ G DP R+ P+HL Sbjct: 125 EIAEALLGAGCDPELRDFRGNTPLHL 150 >gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] Length = 1897 Score = 81.6 bits (200), Expect = 2e-15 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN Sbjct: 82 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 138 Query: 408 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 460 G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V Sbjct: 139 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 192 Query: 461 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 509 +AH +H RN + V LL+N D + Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 236 Query: 510 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 569 K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V Sbjct: 237 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 288 Query: 570 RLLMRKGADPSTRNLENEQPVH 591 RLL+ +GA T+ + P+H Sbjct: 289 RLLLDRGAQIETKTKDELTPLH 310 Score = 80.1 bits (196), Expect = 6e-15 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S+ +G T LHIA + + +L + ++ D +G + VA IV++ Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 455 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 458 L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 509 Query: 459 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 512 A I H N V L+ N P+ + + + V+T+ L++ A+ +A K Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 568 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 621 Query: 573 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 607 + +G P + P+H+ E R +L+ Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656 Score = 75.9 bits (185), Expect = 1e-13 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%) Query: 343 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402 +G T LH+AV + +L + + H NG + +A NQ + + L+ Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 657 Query: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 462 G N G TPLH+ A++GH++++ + N N GLTPLH Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 709 Query: 463 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 522 Q+ H P V ++L+K+ +VD + G T LH+A+ Sbjct: 710 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 743 Query: 523 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 582 N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+ Sbjct: 744 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 796 Query: 583 NLENEQPV 590 + + P+ Sbjct: 797 SSDGTTPL 804 Score = 72.4 bits (176), Expect = 1e-12 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%) Query: 336 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 395 Q +K D T LH A G +S +L ++ + K NG S +A + Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353 Query: 396 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 454 V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 406 Query: 455 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 508 PLH A ++ V EL V E L + +K L+Q GA+ Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 + K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ + Sbjct: 467 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 518 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 612 V+LL+ A+P+ P+H+ E + +L+ ++ Q Sbjct: 519 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562 Score = 70.1 bits (170), Expect = 6e-12 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%) Query: 329 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 L N LSK G T LHIA ++ +L +N ++ NG + +A Sbjct: 226 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 280 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 448 ++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A Sbjct: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 334 Query: 449 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 499 +GL+P+H A + + R + E+ ++ L + + + K L+ Sbjct: 335 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ + Sbjct: 392 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 447 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 + L V+ L+++GA P+ N++ E P+H+ E + +L+ K+ Sbjct: 448 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494 Score = 70.1 bits (170), Expect = 6e-12 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%) Query: 386 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 445 VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K + Sbjct: 377 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 430 Query: 446 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 499 +A GLTPLH A + H +V LQR P+ V+ + + K L+ Sbjct: 431 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 490 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 Q A V AK K +T LH AA + +++L LE + N G+T LH+AA Sbjct: 491 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 544 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 R ++ V L+ K A + + P+H+ Sbjct: 545 --REGHVETVLALLEKEASQACMTKKGFTPLHV 575 >gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] Length = 1881 Score = 81.6 bits (200), Expect = 2e-15 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105 Query: 408 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 460 G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159 Query: 461 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 509 +AH +H RN + V LL+N D + Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203 Query: 510 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 569 K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255 Query: 570 RLLMRKGADPSTRNLENEQPVH 591 RLL+ +GA T+ + P+H Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277 Score = 80.1 bits (196), Expect = 6e-15 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S+ +G T LHIA + + +L + ++ D +G + VA IV++ Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 458 L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476 Query: 459 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 512 A I H N V L+ N P+ + + + V+T+ L++ A+ +A K Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588 Query: 573 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 607 + +G P + P+H+ E R +L+ Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623 Score = 75.9 bits (185), Expect = 1e-13 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%) Query: 343 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402 +G T LH+AV + +L + + H NG + +A NQ + + L+ Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624 Query: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 462 G N G TPLH+ A++GH++++ + N N GLTPLH Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676 Query: 463 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 522 Q+ H P V ++L+K+ +VD + G T LH+A+ Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710 Query: 523 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 582 N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+ Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763 Query: 583 NLENEQPV 590 + + P+ Sbjct: 764 SSDGTTPL 771 Score = 72.4 bits (176), Expect = 1e-12 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%) Query: 336 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 395 Q +K D T LH A G +S +L ++ + K NG S +A + Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 396 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 454 V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373 Query: 455 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 508 PLH A ++ V EL V E L + +K L+Q GA+ Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 + K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ + Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 612 V+LL+ A+P+ P+H+ E + +L+ ++ Q Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529 Score = 70.1 bits (170), Expect = 6e-12 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%) Query: 329 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 L N LSK G T LHIA ++ +L +N ++ NG + +A Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 448 ++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301 Query: 449 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 499 +GL+P+H A + + R + E+ ++ L + + + K L+ Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ + Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 + L V+ L+++GA P+ N++ E P+H+ E + +L+ K+ Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461 Score = 70.1 bits (170), Expect = 6e-12 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%) Query: 386 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 445 VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K + Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397 Query: 446 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 499 +A GLTPLH A + H +V LQR P+ V+ + + K L+ Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 Q A V AK K +T LH AA + +++L LE + N G+T LH+AA Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 R ++ V L+ K A + + P+H+ Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542 Score = 43.5 bits (101), Expect = 6e-04 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%) Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 429 + + +E + ++F A + D + G +NT + G LH+ +++GH V+ Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62 Query: 430 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 488 + + K + LE T G T LH A +A + VV E Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96 Query: 489 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 534 L+ GA V A+ +K G T L++AA+E +LE+++ LE Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132 >gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] Length = 1880 Score = 81.6 bits (200), Expect = 2e-15 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105 Query: 408 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 460 G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159 Query: 461 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 509 +AH +H RN + V LL+N D + Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203 Query: 510 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 569 K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255 Query: 570 RLLMRKGADPSTRNLENEQPVH 591 RLL+ +GA T+ + P+H Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277 Score = 80.1 bits (196), Expect = 6e-15 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S+ +G T LHIA + + +L + ++ D +G + VA IV++ Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 458 L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476 Query: 459 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 512 A I H N V L+ N P+ + + + V+T+ L++ A+ +A K Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588 Query: 573 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 607 + +G P + P+H+ E R +L+ Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623 Score = 75.9 bits (185), Expect = 1e-13 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%) Query: 343 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402 +G T LH+AV + +L + + H NG + +A NQ + + L+ Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624 Query: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 462 G N G TPLH+ A++GH++++ + N N GLTPLH Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676 Query: 463 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 522 Q+ H P V ++L+K+ +VD + G T LH+A+ Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710 Query: 523 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 582 N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+ Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763 Query: 583 NLENEQPV 590 + + P+ Sbjct: 764 SSDGTTPL 771 Score = 72.4 bits (176), Expect = 1e-12 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%) Query: 336 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 395 Q +K D T LH A G +S +L ++ + K NG S +A + Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 396 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 454 V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373 Query: 455 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 508 PLH A ++ V EL V E L + +K L+Q GA+ Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 + K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ + Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 612 V+LL+ A+P+ P+H+ E + +L+ ++ Q Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529 Score = 70.1 bits (170), Expect = 6e-12 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%) Query: 329 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 L N LSK G T LHIA ++ +L +N ++ NG + +A Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 448 ++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301 Query: 449 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 499 +GL+P+H A + + R + E+ ++ L + + + K L+ Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ + Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 + L V+ L+++GA P+ N++ E P+H+ E + +L+ K+ Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461 Score = 70.1 bits (170), Expect = 6e-12 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%) Query: 386 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 445 VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K + Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397 Query: 446 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 499 +A GLTPLH A + H +V LQR P+ V+ + + K L+ Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 Q A V AK K +T LH AA + +++L LE + N G+T LH+AA Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 R ++ V L+ K A + + P+H+ Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542 Score = 43.5 bits (101), Expect = 6e-04 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%) Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 429 + + +E + ++F A + D + G +NT + G LH+ +++GH V+ Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62 Query: 430 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 488 + + K + LE T G T LH A +A + VV E Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96 Query: 489 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 534 L+ GA V A+ +K G T L++AA+E +LE+++ LE Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132 >gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] Length = 1719 Score = 81.6 bits (200), Expect = 2e-15 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105 Query: 408 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 460 G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159 Query: 461 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 509 +AH +H RN + V LL+N D + Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203 Query: 510 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 569 K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255 Query: 570 RLLMRKGADPSTRNLENEQPVH 591 RLL+ +GA T+ + P+H Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277 Score = 80.1 bits (196), Expect = 6e-15 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S+ +G T LHIA + + +L + ++ D +G + VA IV++ Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 458 L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476 Query: 459 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 512 A I H N V L+ N P+ + + + V+T+ L++ A+ +A K Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588 Query: 573 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 607 + +G P + P+H+ E R +L+ Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623 Score = 75.9 bits (185), Expect = 1e-13 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%) Query: 343 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402 +G T LH+AV + +L + + H NG + +A NQ + + L+ Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624 Query: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 462 G N G TPLH+ A++GH++++ + N N GLTPLH Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676 Query: 463 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 522 Q+ H P V ++L+K+ +VD + G T LH+A+ Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710 Query: 523 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 582 N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+ Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763 Query: 583 NLENEQPV 590 + + P+ Sbjct: 764 SSDGTTPL 771 Score = 72.4 bits (176), Expect = 1e-12 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%) Query: 336 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 395 Q +K D T LH A G +S +L ++ + K NG S +A + Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 396 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 454 V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373 Query: 455 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 508 PLH A ++ V EL V E L + +K L+Q GA+ Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 + K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ + Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 612 V+LL+ A+P+ P+H+ E + +L+ ++ Q Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529 Score = 70.1 bits (170), Expect = 6e-12 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%) Query: 329 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 L N LSK G T LHIA ++ +L +N ++ NG + +A Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 448 ++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301 Query: 449 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 499 +GL+P+H A + + R + E+ ++ L + + + K L+ Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ + Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 + L V+ L+++GA P+ N++ E P+H+ E + +L+ K+ Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461 Score = 70.1 bits (170), Expect = 6e-12 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%) Query: 386 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 445 VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K + Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397 Query: 446 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 499 +A GLTPLH A + H +V LQR P+ V+ + + K L+ Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 Q A V AK K +T LH AA + +++L LE + N G+T LH+AA Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 R ++ V L+ K A + + P+H+ Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542 Score = 43.5 bits (101), Expect = 6e-04 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%) Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 429 + + +E + ++F A + D + G +NT + G LH+ +++GH V+ Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62 Query: 430 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 488 + + K + LE T G T LH A +A + VV E Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96 Query: 489 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 534 L+ GA V A+ +K G T L++AA+E +LE+++ LE Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132 >gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] Length = 1856 Score = 81.6 bits (200), Expect = 2e-15 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105 Query: 408 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 460 G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159 Query: 461 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 509 +AH +H RN + V LL+N D + Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203 Query: 510 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 569 K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255 Query: 570 RLLMRKGADPSTRNLENEQPVH 591 RLL+ +GA T+ + P+H Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277 Score = 80.1 bits (196), Expect = 6e-15 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S+ +G T LHIA + + +L + ++ D +G + VA IV++ Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 458 L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476 Query: 459 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 512 A I H N V L+ N P+ + + + V+T+ L++ A+ +A K Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588 Query: 573 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 607 + +G P + P+H+ E R +L+ Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623 Score = 75.9 bits (185), Expect = 1e-13 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%) Query: 343 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402 +G T LH+AV + +L + + H NG + +A NQ + + L+ Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624 Query: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 462 G N G TPLH+ A++GH++++ + N N GLTPLH Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676 Query: 463 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 522 Q+ H P V ++L+K+ +VD + G T LH+A+ Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710 Query: 523 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 582 N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+ Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763 Query: 583 NLENEQPV 590 + + P+ Sbjct: 764 SSDGTTPL 771 Score = 72.4 bits (176), Expect = 1e-12 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%) Query: 336 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 395 Q +K D T LH A G +S +L ++ + K NG S +A + Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320 Query: 396 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 454 V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373 Query: 455 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 508 PLH A ++ V EL V E L + +K L+Q GA+ Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 + K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ + Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 612 V+LL+ A+P+ P+H+ E + +L+ ++ Q Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529 Score = 70.1 bits (170), Expect = 6e-12 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%) Query: 329 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 L N LSK G T LHIA ++ +L +N ++ NG + +A Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 448 ++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301 Query: 449 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 499 +GL+P+H A + + R + E+ ++ L + + + K L+ Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ + Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 + L V+ L+++GA P+ N++ E P+H+ E + +L+ K+ Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461 Score = 70.1 bits (170), Expect = 6e-12 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%) Query: 386 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 445 VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K + Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397 Query: 446 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 499 +A GLTPLH A + H +V LQR P+ V+ + + K L+ Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 Q A V AK K +T LH AA + +++L LE + N G+T LH+AA Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 R ++ V L+ K A + + P+H+ Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542 Score = 43.5 bits (101), Expect = 6e-04 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%) Query: 371 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 429 + + +E + ++F A + D + G +NT + G LH+ +++GH V+ Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62 Query: 430 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 488 + + K + LE T G T LH A +A + VV E Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96 Query: 489 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 534 L+ GA V A+ +K G T L++AA+E +LE+++ LE Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132 >gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] Length = 1863 Score = 79.0 bits (193), Expect = 1e-14 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T LHIA G ++ +L + A+ D NG + VA +V+ L++ G Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 268 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 459 Q++ G TPLH A GH QV++ +++GA L A +GL+PLH A Sbjct: 269 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 321 Query: 460 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 484 ++ H A V + L + P++ + Sbjct: 322 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 381 Query: 485 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 543 + K+ + ++ L++ GA+++A +SG T +H+AA +L ++ L L+ + N Sbjct: 382 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 440 Query: 544 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 + G TALH+AA R Q++ VR L+R GA R E + P+H+ Sbjct: 441 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 482 Score = 79.0 bits (193), Expect = 1e-14 Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S +G T LH+A + ++ +L K + H NG + +A NQ I Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 626 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 457 L+N GA+ N G TPLH+ +++GH+ V + KGA ++ + GLT LH Sbjct: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 679 Query: 458 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 511 A +A H ++ ++ + V + L++ GA V AK K Sbjct: 680 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 738 Query: 512 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 571 +G T LH AA++ + +I + L+ + NA NGNTAL +A L Y ++ +D +++ Sbjct: 739 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 794 Query: 572 LMRKGADPSTRNLENEQ 588 + + +T E + Sbjct: 795 VTEEVTTTTTTITEKHK 811 Score = 72.4 bits (176), Expect = 1e-12 Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G+T LHIA G+ + VL ++ ++ + NG + +A N +V+ L+ G Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 132 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 463 A +T G TPL V ++GH+Q + + ++ + L LH A Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 182 Query: 464 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 508 + L Q H+ +VQ ++ N++ V+ L+ GAAV+ Sbjct: 183 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 R +G T LH+A++ N +++L L+ ++AK +G T LH AA R Sbjct: 242 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 293 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 V LL+ +GA R P+H+ G E ++ +L+ K+ Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 335 Score = 70.9 bits (172), Expect = 3e-12 Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T +H+A G L+ VL N D+ G++A +A A Q +V+ L+ G Sbjct: 410 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 466 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 457 A V+ +TPLH+ + G ++++Q + + +A +G TPLH Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 520 Query: 458 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 513 +V+ H L ++ +P + K SL D K L+Q AA ++ K+G Sbjct: 521 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 575 Query: 514 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 573 T LH+AA N ++ L LE + +A A NG T LH+AA + Q+ L+ Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 628 Query: 574 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 611 GA+ + + P+HL + + +L KG +I Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667 Score = 44.3 bits (103), Expect = 3e-04 Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%) Query: 376 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 435 K + S + A A N +V+ L G +NT + G LH+ A++GH ++Q + Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 62 Query: 436 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 495 +G VD + G T LH A +A A + + Sbjct: 63 -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 92 Query: 496 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 534 K L++ GA + A+ ++G T L++AA+E ++++++ LE Sbjct: 93 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 130 >gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] Length = 1872 Score = 79.0 bits (193), Expect = 1e-14 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T LHIA G ++ +L + A+ D NG + VA +V+ L++ G Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 289 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 459 Q++ G TPLH A GH QV++ +++GA L A +GL+PLH A Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 342 Query: 460 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 484 ++ H A V + L + P++ + Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402 Query: 485 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 543 + K+ + ++ L++ GA+++A +SG T +H+AA +L ++ L L+ + N Sbjct: 403 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461 Query: 544 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 + G TALH+AA R Q++ VR L+R GA R E + P+H+ Sbjct: 462 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 503 Score = 79.0 bits (193), Expect = 1e-14 Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S +G T LH+A + ++ +L K + H NG + +A NQ I Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 647 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 457 L+N GA+ N G TPLH+ +++GH+ V + KGA ++ + GLT LH Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 700 Query: 458 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 511 A +A H ++ ++ + V + L++ GA V AK K Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 759 Query: 512 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 571 +G T LH AA++ + +I + L+ + NA NGNTAL +A L Y ++ +D +++ Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 815 Query: 572 LMRKGADPSTRNLENEQ 588 + + +T E + Sbjct: 816 VTEEVTTTTTTITEKHK 832 Score = 72.4 bits (176), Expect = 1e-12 Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G+T LHIA G+ + VL ++ ++ + NG + +A N +V+ L+ G Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 153 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 463 A +T G TPL V ++GH+Q + + ++ + L LH A Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 203 Query: 464 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 508 + L Q H+ +VQ ++ N++ V+ L+ GAAV+ Sbjct: 204 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 R +G T LH+A++ N +++L L+ ++AK +G T LH AA R Sbjct: 263 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 314 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 V LL+ +GA R P+H+ G E ++ +L+ K+ Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356 Score = 70.9 bits (172), Expect = 3e-12 Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T +H+A G L+ VL N D+ G++A +A A Q +V+ L+ G Sbjct: 431 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 487 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 457 A V+ +TPLH+ + G ++++Q + + +A +G TPLH Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 541 Query: 458 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 513 +V+ H L ++ +P + K SL D K L+Q AA ++ K+G Sbjct: 542 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 596 Query: 514 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 573 T LH+AA N ++ L LE + +A A NG T LH+AA + Q+ L+ Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 649 Query: 574 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 611 GA+ + + P+HL + + +L KG +I Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688 Score = 44.3 bits (103), Expect = 3e-04 Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%) Query: 376 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 435 K + S + A A N +V+ L G +NT + G LH+ A++GH ++Q + Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 83 Query: 436 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 495 +G VD + G T LH A +A A + + Sbjct: 84 -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 113 Query: 496 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 534 K L++ GA + A+ ++G T L++AA+E ++++++ LE Sbjct: 114 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 151 >gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] Length = 3957 Score = 79.0 bits (193), Expect = 1e-14 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T LHIA G ++ +L + A+ D NG + VA +V+ L++ G Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 289 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 459 Q++ G TPLH A GH QV++ +++GA L A +GL+PLH A Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 342 Query: 460 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 484 ++ H A V + L + P++ + Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402 Query: 485 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 543 + K+ + ++ L++ GA+++A +SG T +H+AA +L ++ L L+ + N Sbjct: 403 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461 Query: 544 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 + G TALH+AA R Q++ VR L+R GA R E + P+H+ Sbjct: 462 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 503 Score = 79.0 bits (193), Expect = 1e-14 Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 S +G T LH+A + ++ +L K + H NG + +A NQ I Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 647 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 457 L+N GA+ N G TPLH+ +++GH+ V + KGA ++ + GLT LH Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 700 Query: 458 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 511 A +A H ++ ++ + V + L++ GA V AK K Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 759 Query: 512 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 571 +G T LH AA++ + +I + L+ + NA NGNTAL +A L Y ++ +D +++ Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 815 Query: 572 LMRKGADPSTRNLENEQ 588 + + +T E + Sbjct: 816 VTEEVTTTTTTITEKHK 832 Score = 72.4 bits (176), Expect = 1e-12 Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G+T LHIA G+ + VL ++ ++ + NG + +A N +V+ L+ G Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 153 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 463 A +T G TPL V ++GH+Q + + ++ + L LH A Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 203 Query: 464 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 508 + L Q H+ +VQ ++ N++ V+ L+ GAAV+ Sbjct: 204 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 R +G T LH+A++ N +++L L+ ++AK +G T LH AA R Sbjct: 263 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 314 Query: 569 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 610 V LL+ +GA R P+H+ G E ++ +L+ K+ Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356 Score = 70.9 bits (172), Expect = 3e-12 Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T +H+A G L+ VL N D+ G++A +A A Q +V+ L+ G Sbjct: 431 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 487 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 457 A V+ +TPLH+ + G ++++Q + + +A +G TPLH Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 541 Query: 458 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 513 +V+ H L ++ +P + K SL D K L+Q AA ++ K+G Sbjct: 542 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 596 Query: 514 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 573 T LH+AA N ++ L LE + +A A NG T LH+AA + Q+ L+ Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 649 Query: 574 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 611 GA+ + + P+HL + + +L KG +I Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688 Score = 44.3 bits (103), Expect = 3e-04 Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%) Query: 376 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 435 K + S + A A N +V+ L G +NT + G LH+ A++GH ++Q + Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 83 Query: 436 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 495 +G VD + G T LH A +A A + + Sbjct: 84 -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 113 Query: 496 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 534 K L++ GA + A+ ++G T L++AA+E ++++++ LE Sbjct: 114 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 151 >gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] Length = 4377 Score = 77.0 bits (188), Expect = 5e-14 Identities = 74/281 (26%), Positives = 127/281 (45%), Gaps = 23/281 (8%) Query: 310 TTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGD---TFLHIAVAQGRRALSYVLARK 366 TT+ G + + + ++AN+ + S DA G T LH+A + ++ +L + Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620 Query: 367 MNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHS 426 + H NG + +A NQ I L+ GA N G +H+ A++GH Sbjct: 621 GASPHAA---AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677 Query: 427 QVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL 486 ++ + +G N V+L +N GLTPLH A V E+ NQ H ++ Sbjct: 678 DMVSLL----LGRNANVNL--SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731 Query: 487 KNKSL------VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 540 + + + L+Q A V AK K+G T LH AA++ + +I + L+ + Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNAS-- 788 Query: 541 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPST 581 N NGNTAL +A L Y ++ +D ++++ + +T Sbjct: 789 -PNELTVNGNTALGIARRLGY-ISVVDTLKIVTEETMTTTT 827 Score = 73.9 bits (180), Expect = 4e-13 Identities = 71/255 (27%), Positives = 110/255 (43%), Gaps = 46/255 (18%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 +K +G T LHIA + R + +L + ++ + +G + VA IV Sbjct: 395 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT---ESGLTPIHVAAFMGHVNIVSQ 451 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLH 457 L++ GA NTT+ G T LH+ A G ++V++ +Q GA +EA D TPLH Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA-------QVEAKAKDDQTPLH 504 Query: 458 CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 517 + A D ++ L+Q GA+ A SG T L Sbjct: 505 ISARLGKA---------------------------DIVQQLLQQGASPNAA-TTSGYTPL 536 Query: 518 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 577 HL+A E + ++ L+ + LS K G T LHVAA + +L+ LL++K A Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKK---GFTPLHVAA----KYGKLEVANLLLQKSA 589 Query: 578 DPSTRNLENEQPVHL 592 P P+H+ Sbjct: 590 SPDAAGKSGLTPLHV 604 Score = 70.9 bits (172), Expect = 3e-12 Identities = 72/279 (25%), Positives = 125/279 (44%), Gaps = 24/279 (8%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T LHIA G ++ +L +N +D N + VA +V+ L++ G Sbjct: 235 GFTPLHIAAHYGNINVATLL---LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG 291 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA- 462 A+++ G TPLH A GH QV++ + A + + +GL+PLH A Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA------APILSKTKNGLSPLHMATQGD 345 Query: 463 HNAVVHELQRNQQPHSPEVQELL-----LKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 517 H V L ++ P + L + K L+ A AK +G T L Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK-ALNGFTPL 404 Query: 518 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 577 H+A ++ ++++ L L+ + + A +G T +HVAA + + ++ V LM GA Sbjct: 405 HIACKKNRIKVMELLLKHGAS---IQAVTESGLTPIHVAAFMGH----VNIVSQLMHHGA 457 Query: 578 DPSTRNLENEQPVHLVPDGPVGEQIRRILK-GKSIQQRA 615 P+T N+ E +H+ E +R +++ G ++ +A Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496 Score = 67.4 bits (163), Expect = 4e-11 Identities = 71/282 (25%), Positives = 120/282 (42%), Gaps = 44/282 (15%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G+T LH+A G+ + L + ++ K + Q+ ++ + IVQ L+ G Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGA---QVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAI-----------QKGAV--------GSNQFVD 444 A N G TPLH+ A +GH V + +KG G + + Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582 Query: 445 L--------EATNYDGLTPLHCAVIAHNAVVHELQRNQ--QPHSPEVQEL----LLKNKS 490 L +A GLTPLH A N V L +Q PH+ + K+ Sbjct: 583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642 Query: 491 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 550 +D L++ GA A R+ G ++HLAA+E +++++ L L + VN +G Sbjct: 643 QMDIATTLLEYGADANAVTRQ-GIASVHLAAQEGHVDMVSLLL---GRNANVNLSNKSGL 698 Query: 551 TALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 T LH+AA + +++ +L+ +GA + P+H+ Sbjct: 699 TPLHLAA----QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736 Score = 66.2 bits (160), Expect = 8e-11 Identities = 66/255 (25%), Positives = 109/255 (42%), Gaps = 23/255 (9%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T +H+A G + L + + +++ G++A +A + Q +V+ LV G Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR---GETALHMAARSGQAEVVRYLVQDG 489 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV--- 460 AQV +TPLH+ A G + ++Q + + N A G TPLH + Sbjct: 490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN------AATTSGYTPLHLSAREG 543 Query: 461 ---IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 517 +A + H + + ++ L+Q A+ +A KSG T L Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG-KSGLTPL 602 Query: 518 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 577 H+AA N ++ L L+ + +A A NG T LH+AA + Q+D L+ GA Sbjct: 603 HVAAHYDNQKVALLLLDQGAS---PHAAAKNGYTPLHIAA----KKNQMDIATTLLEYGA 655 Query: 578 DPSTRNLENEQPVHL 592 D + + VHL Sbjct: 656 DANAVTRQGIASVHL 670 Score = 55.8 bits (133), Expect = 1e-07 Identities = 73/304 (24%), Positives = 119/304 (39%), Gaps = 56/304 (18%) Query: 324 QEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSA 383 +++ K S+D+ DA+ +AL Y+ N + ++I NG +A Sbjct: 23 EKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYI----KNGVD-INICNQNGLNA 77 Query: 384 FQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV 443 +A +V +L+ A V+ G T LH+ + G ++V++ + N Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN--- 134 Query: 444 DLEATNYDGLTPLHCAVIA-HNAVVHELQRN-------------------QQPHSPEVQE 483 A + +G TPL+ A H VV L N QQ H +V Sbjct: 135 ---AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD-QVVS 190 Query: 484 LLLKN----------------KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLE 527 LLL+N K L+Q + + KSG T LH+AA N+ Sbjct: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV-ESKSGFTPLHIAAHYGNIN 249 Query: 528 LIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENE 587 + L L + + F A N T LHVA+ + + V+LL+ +GA + + Sbjct: 250 VATLLLNRAAAVDFT---ARNDITPLHVAS----KRGNANMVKLLLDRGAKIDAKTRDGL 302 Query: 588 QPVH 591 P+H Sbjct: 303 TPLH 306 >gi|55742857 ankyrin repeat domain 6 [Homo sapiens] Length = 722 Score = 76.3 bits (186), Expect = 8e-14 Identities = 70/215 (32%), Positives = 100/215 (46%), Gaps = 25/215 (11%) Query: 386 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 445 VA Q V L+N GA+V T GRTPLH+ A KGH V+Q + K DL Sbjct: 16 VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAG------CDL 68 Query: 446 EATNYDGLTPLHCAVIAHN-----AVVHE---LQRNQQPHSPEVQELLLKNKSLVDTIKC 497 + + T LH A + N A++HE L R + + + E S + K Sbjct: 69 DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFS--QSAKL 126 Query: 498 LIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAA 557 L++ GA V AK+ K+G TALHLA + ++ + R+ L S N G+T LHVAA Sbjct: 127 LVKAGANVLAKN-KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA---GDTCLHVAA 182 Query: 558 SLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 R L +RLL+ +N + +H+ Sbjct: 183 ----RYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213 Score = 72.4 bits (176), Expect = 1e-12 Identities = 79/300 (26%), Positives = 133/300 (44%), Gaps = 53/300 (17%) Query: 324 QEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSA 383 Q E+ + I++ ++ G T LH+A +G + +L + A LD+++ Q+A Sbjct: 22 QTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQIL---LKAGCDLDVQDDGDQTA 78 Query: 384 FQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV 443 A I+ L++ G ++ D G T LH + G SQ + + K G+N Sbjct: 79 LHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK--AGAN--- 133 Query: 444 DLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGA 503 + A N G T LH A Q HS + LLL G+ Sbjct: 134 -VLAKNKAGNTALHLAC-------------QNSHSQSTRVLLL--------------AGS 165 Query: 504 AVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRL 563 + K+ +G T LH+AA +L +IRL L + V+ K G+TALHVAA+L ++ Sbjct: 166 RADLKN-NAGDTCLHVAARYNHLSIIRLLL---TAFCSVHEKNQAGDTALHVAAALNHK- 220 Query: 564 TQLDAVRLLMRKGADPSTRNLENEQPV-----HLVPDGPV----GEQIRRILKGKSIQQR 614 ++L+ GAD + N + P+ H P+ + Q+ R +G+S++++ Sbjct: 221 ---KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKK 277 Score = 44.7 bits (104), Expect = 3e-04 Identities = 39/148 (26%), Positives = 61/148 (41%), Gaps = 9/148 (6%) Query: 320 WQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHN 379 W + +KL + L+K+ G+T LH+A + VL + A D+K + Sbjct: 117 WHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL---LLAGSRADLKNNA 173 Query: 380 GQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGS 439 G + VA N I++ L+ V+ + G T LHV A H +V + + + Sbjct: 174 GDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG--- 230 Query: 440 NQFVDLEATNYDGLTPLHCAVIAHNAVV 467 D N G TPL A +N V Sbjct: 231 ---ADTTIVNNAGQTPLETARYHNNPEV 255 >gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo sapiens] Length = 765 Score = 75.5 bits (184), Expect = 1e-13 Identities = 74/260 (28%), Positives = 121/260 (46%), Gaps = 27/260 (10%) Query: 341 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 400 D DG LH A G + +L ++ +D +E G + +A N + + LV Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLL---LDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481 Query: 401 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 460 + A N + G+TPLHV A GH +++ + ++Q +L+A + TPLH AV Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL------TSQGAELDAQQRNLRTPLHLAV 535 Query: 461 IAH--NAVVHELQRNQQPHSPE------VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 512 A+ H L+ P + + + + K L+ K L++ GA++E + Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLI--CKMLLRYGASLELPTHQ- 592 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 G T LHLAA + +LE+I L E + + + A + T LH+AA R + V L Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNW---TPLHLAA----RHGEEAVVSAL 645 Query: 573 MRKGADPSTRNLENEQPVHL 592 ++ GADP+ P+HL Sbjct: 646 LQCGADPNAAEQSGWTPLHL 665 Score = 60.8 bits (146), Expect = 3e-09 Identities = 68/252 (26%), Positives = 112/252 (44%), Gaps = 29/252 (11%) Query: 346 TFLHIAVAQGR-RALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGA 404 T LH+AV +G+ RA+ ++L K A+ D + +G A A ++LI + L+ GA Sbjct: 529 TPLHLAVERGKVRAIQHLL--KSGAVP--DALDQSGYGPLHTAAARGKYLICKMLLRYGA 584 Query: 405 QVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV-IAH 463 + G TPLH+ A KGH +++ + + L A N+ TPLH A Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA---LGAVNW---TPLHLAARHGE 638 Query: 464 NAVVHE-LQRNQQPHSPEVQ-----ELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 517 AVV LQ P++ E L ++ + + I L++ A V A++ K G T Sbjct: 639 EAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN-LLEHHANVHARN-KVGWTPA 696 Query: 518 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 577 HLAA + N ++++ +E + L + + LQ L + +G Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVS---------CTPLQLALRSRKQGIMSFLEGK 747 Query: 578 DPSTRNLENEQP 589 +PS L +P Sbjct: 748 EPSVATLGGSKP 759 Score = 46.2 bits (108), Expect = 9e-05 Identities = 51/203 (25%), Positives = 82/203 (40%), Gaps = 20/203 (9%) Query: 415 TPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV------IAHNAVVH 468 TPLH +G + ++ + V D++ G TPL A + + H Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEV------DVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417 Query: 469 ELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLEL 528 N+ T + L+ GA V+A++R+ G T LHLAA+ + Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENV 476 Query: 529 IRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQ 588 RL L S + N G T LHVAA + + V+LL +GA+ + Sbjct: 477 ARL---LVSRQADPNLHEAEGKTPLHVAAYFGH----VSLVKLLTSQGAELDAQQRNLRT 529 Query: 589 PVHLVPDGPVGEQIRRILKGKSI 611 P+HL + I+ +LK ++ Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAV 552 >gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo sapiens] Length = 226 Score = 74.3 bits (181), Expect = 3e-13 Identities = 63/233 (27%), Positives = 109/233 (46%), Gaps = 44/233 (18%) Query: 377 EHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQ-KG 435 + + ++A A +A IV+ L+ +G VN D G +PLH+ A G ++++A+ KG Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 Query: 436 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 495 A + A N +G TPLH A +K+ + Sbjct: 97 A-------QVNAVNQNGCTPLHYAA---------------------------SKNRHEIA 122 Query: 496 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHV 555 L++ GA +AKD TA+H AA + NL++I + L + N + GNT LH+ Sbjct: 123 VMLLEGGANPDAKDHYEA-TAMHRAAAKGNLKMIHILLYYKAS---TNIQDTEGNTPLHL 178 Query: 556 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKG 608 A + +++ +LL+ +GA N E + P+ V G +G ++R+++G Sbjct: 179 ACDEE----RVEEAKLLVSQGASIYIENKEEKTPLQ-VAKGGLGLILKRMVEG 226 Score = 51.2 bits (121), Expect = 3e-06 Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 4/191 (2%) Query: 341 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 400 D D T LH A + G + L + ++ K+ G S +A +A + IV+ L+ Sbjct: 37 DQDSRTALHWACSAGHTEIVEFL---LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93 Query: 401 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 460 GAQVN + G TPLH A K ++ + +G + EAT Sbjct: 94 GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLK 153 Query: 461 IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLA 520 + H + ++ N Q L ++ V+ K L+ GA++ + K +T L +A Sbjct: 154 MIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI-ENKEEKTPLQVA 212 Query: 521 AEEANLELIRL 531 L L R+ Sbjct: 213 KGGLGLILKRM 223 >gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [Homo sapiens] Length = 1166 Score = 72.4 bits (176), Expect = 1e-12 Identities = 84/309 (27%), Positives = 127/309 (41%), Gaps = 38/309 (12%) Query: 332 ISQDQFLSKDADG--DTFLHIAVAQGRR-ALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 ++ ++ S+D G T LH A GR+ + Y+L N + ++ G A Sbjct: 44 VTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN----VQARDDGGLIPLHNAC 99 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQV-LQAIQKGAVGSNQFVDLEA 447 + +V L+ GA N D W TPLH A KG V + +Q GA + + D Sbjct: 100 SFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTD-GR 158 Query: 448 TNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSL---------------- 491 T D P AV+ EL + + + E LL ++ Sbjct: 159 TALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLA 218 Query: 492 -----VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKA 546 V ++ L+Q GA V AKD K LH A + E+ L ++ +C VNA Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKD-KGDLVPLHNACSYGHYEVTELLVKHGAC---VNAMD 274 Query: 547 YNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 606 T LH AAS +++ LL+ GADP+ N N+ + L P + E++ Sbjct: 275 LWQFTPLHEAASKN----RVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330 Query: 607 KGKSIQQRA 615 KG S+ Q A Sbjct: 331 KGHSLLQAA 339 Score = 71.2 bits (173), Expect = 3e-12 Identities = 88/320 (27%), Positives = 132/320 (41%), Gaps = 49/320 (15%) Query: 303 NMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYV 362 ++GN QL ++ VE + KL + + T LH A R ++ Sbjct: 486 SLGNSEADRQLLEAAKAGDVETVK-KLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544 Query: 363 LARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAE 422 L + +H K+ G A + + + + LV GA VN D W TPLH A Sbjct: 545 LLQHGADVHA---KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601 Query: 423 KGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEV 481 KG ++ + +Q GA D N DG TPL V + + +L R Sbjct: 602 KGKYEICKLLLQHGA-------DPTKKNRDGNTPLD-LVKDGDTDIQDLLRGDAALLDAA 653 Query: 482 QELLL---KNKSLVDTIKC-------------------------LIQMGAAVEAKDRKSG 513 ++ L K S D + C L+Q GA V A+D K G Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQD-KGG 712 Query: 514 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 573 LH AA ++++ L ++ +C++ + A+ T LH AA Q TQL A LL+ Sbjct: 713 LIPLHNAASYGHVDVAALLIKYNACVNATDKWAF---TPLHEAA--QKGRTQLCA--LLL 765 Query: 574 RKGADPSTRNLENEQPVHLV 593 GADP+ +N E + P+ LV Sbjct: 766 AHGADPTLKNQEGQTPLDLV 785 Score = 56.2 bits (134), Expect = 9e-08 Identities = 70/271 (25%), Positives = 117/271 (43%), Gaps = 35/271 (12%) Query: 346 TFLHIAVAQGRRALSYVLAR---KMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402 T LH+A + + V+ + K+NAL L GQ++ A + L++ Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNL------GQTSLHRAAYCGHLQTCRLLLSY 455 Query: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVD---LEATNYDGLTPLH-- 457 G N G T L + G+ V Q +Q+G N D LEA + + Sbjct: 456 GCDPNIISLQGFTALQM----GNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKL 511 Query: 458 CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 517 C V + N E +++ H + V ++ L+Q GA V AKD K G L Sbjct: 512 CTVQSVNCRDIEGRQSTPLH-------FAAGYNRVSVVEYLLQHGADVHAKD-KGGLVPL 563 Query: 518 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 577 H A + E+ L ++ + ++ + + T LH AA+ + + +LL++ GA Sbjct: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKF---TPLHEAAAKG----KYEICKLLLQHGA 616 Query: 578 DPSTRNLENEQPVHLVPDGPVGEQIRRILKG 608 DP+ +N + P+ LV DG I+ +L+G Sbjct: 617 DPTKKNRDGNTPLDLVKDGDT--DIQDLLRG 645 Score = 50.4 bits (119), Expect = 5e-06 Identities = 60/226 (26%), Positives = 99/226 (43%), Gaps = 25/226 (11%) Query: 386 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 445 +A N+ IVQ L+ GA V+ D PLH GH +V + + K N Sbjct: 217 LAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN----- 271 Query: 446 EATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAV 505 A + TPLH A + V L + + + L NKS +D + Sbjct: 272 -AMDLWQFTPLHEAASKNRVEVCSLLLS---YGADPTLLNCHNKSAID-------LAPTP 320 Query: 506 EAKDRKS----GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQY 561 + K+R + G + L AA EA++ I+ L L ++F + + + TALH AA+ Y Sbjct: 321 QLKERLAYEFKGHSLLQ-AAREADVTRIKKHLSL-EMVNFKHPQTHE--TALHCAAASPY 376 Query: 562 RLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 607 + LL+RKGA+ + + E P+H+ + + + ++K Sbjct: 377 PKRK-QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421 >gi|68131557 ankyrin repeat domain 28 [Homo sapiens] Length = 1053 Score = 71.2 bits (173), Expect = 3e-12 Identities = 73/275 (26%), Positives = 118/275 (42%), Gaps = 28/275 (10%) Query: 341 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 400 D G T LH A G + +L + ++ D K+ A A +V+ LV Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR---AIHWAAYMGHIEVVKLLV 193 Query: 401 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 460 + GA+V D TPLH A G V++ + + VD+ N G TPLH A Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL------DLGVDMNEPNAYGNTPLHVAC 247 Query: 461 I-AHNAVVHEL--------QRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 511 + VV+EL Q+N++ +P + +L ++ L+ GA V K K Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC--LELLVGNGADVNMKS-K 304 Query: 512 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 571 G+T LH+ A + ++ + ++ + NGNT LH+AA + L + Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAV---IDCEDKNGNTPLHIAARYGHELL----INT 357 Query: 572 LMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 606 L+ GAD + R + P+HL + R++L Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392 Score = 66.2 bits (160), Expect = 8e-11 Identities = 70/277 (25%), Positives = 125/277 (45%), Gaps = 24/277 (8%) Query: 323 EQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDI--KEHNG 380 + E +L +S + +KD+ T LH AVA VL + H D+ ++ N Sbjct: 53 DAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-----HSADVNARDKNW 107 Query: 381 QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN 440 Q+ +A A + LV + + VN +D GRT LH A GH ++++ + N Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167 Query: 441 QF--VDLEATN---YDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 495 F D A + Y G + +++H A V ++++ ++P + ++ + Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV--TCKDKKSYTP---LHAAASSGMISVV 222 Query: 496 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHV 555 K L+ +G + + G T LH+A ++ EL C + VN K G T LH Sbjct: 223 KYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN---ELIDCGAIVNQKNEKGFTPLHF 278 Query: 556 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 AA+ + L+ LL+ GAD + ++ + + P+H+ Sbjct: 279 AAASTHGALCLE---LLVGNGADVNMKSKDGKTPLHM 312 Score = 60.5 bits (145), Expect = 5e-09 Identities = 94/402 (23%), Positives = 154/402 (38%), Gaps = 87/402 (21%) Query: 287 GHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKL---ANISQDQFLSKDAD 343 GH A + SL ++ N T L + F+ VE + + A+I ++ K Sbjct: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKR-- 618 Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 T +H A G +L + +DI++ NGQ+ ++V V L+N G Sbjct: 619 --TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQA-IQKGA-------------------------- 436 A V+ D WGRT LH A GH + + A +Q GA Sbjct: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736 Query: 437 --VGSNQFVDLEATNYD--GLTPLHCAVIAHNAVVHELQRNQQ--------PHSPEVQEL 484 + S +D D G T LH A + EL Q+ SP + Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796 Query: 485 LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNA 544 + N+ + + + +GA++ GRT LH AA ++E ++L L + ++ V++ Sbjct: 797 INDNEGAAEML--IDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854 Query: 545 --------KAYNG-----------------------NTALHVAASLQYRLTQLDAVRLLM 573 A NG NTALH+A S + + L L++ Sbjct: 855 TGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSAL----LIL 910 Query: 574 RKGADPSTRNLEN---EQPVHLVPDGPVGEQIRRIL-KGKSI 611 K D + N N + P+H+ + ++ +L KG S+ Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952 Score = 58.9 bits (141), Expect = 1e-08 Identities = 71/259 (27%), Positives = 106/259 (40%), Gaps = 23/259 (8%) Query: 340 KDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDL 399 K+ G T LH A A AL L A +++K +G++ + + Q + Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELLVGNGA--DVNMKSKDGKTPLHMTALHGRFSRSQTI 325 Query: 400 VNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQA-IQKGAVGSNQFVDLEATNYDGLTPLHC 458 + GA ++ D G TPLH+ A GH ++ I GA D G+ PLH Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA-------DTAKRGIHGMFPLHL 378 Query: 459 AVIA--HNAVVHELQRNQQPHSP-EVQELLLKNKSLVDTIKC---LIQMGAAVEAKDRKS 512 A ++ + L +P + L + ++C L+ GA KD K Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD-KF 437 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 GR+ LH AA N + LF + S S VN G T LH AA+ T + L Sbjct: 438 GRSPLHYAAANCNYQC--LFALVGSGAS-VNDLDERGCTPLHYAATSD---TDGKCLEYL 491 Query: 573 MRKGADPSTRNLENEQPVH 591 +R A+P R+ + VH Sbjct: 492 LRNDANPGIRDKQGYNAVH 510 Score = 57.0 bits (136), Expect = 5e-08 Identities = 58/207 (28%), Positives = 98/207 (47%), Gaps = 30/207 (14%) Query: 396 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTP 455 V+ L+ VN D RTPLH A G +++++ + N A + LTP Sbjct: 24 VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN------AKDSKWLTP 77 Query: 456 LHCAV-----------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAA 504 LH AV + H+A V+ +N Q + NK+ V + L+ + + Sbjct: 78 LHRAVASCSEEAVQVLLKHSADVNARDKNWQ----TPLHIAAANKA-VKCAEALVPLLSN 132 Query: 505 VEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLT 564 V DR +GRTALH AA + E+++L L S + +NA A+H AA + + Sbjct: 133 VNVSDR-AGRTALHHAAFSGHGEMVKLLL---SRGANINAFDKKDRRAIHWAAYMGH--- 185 Query: 565 QLDAVRLLMRKGADPSTRNLENEQPVH 591 ++ V+LL+ GA+ + ++ ++ P+H Sbjct: 186 -IEVVKLLVSHGAEVTCKDKKSYTPLH 211 Score = 55.8 bits (133), Expect = 1e-07 Identities = 56/237 (23%), Positives = 99/237 (41%), Gaps = 42/237 (17%) Query: 373 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 432 ++ +++ ++ A I++ L+ GA+VN D TPLH + +Q + Sbjct: 34 VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93 Query: 433 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 492 K + D+ A + + TPLH A N+ E LL N ++ Sbjct: 94 LKHS------ADVNARDKNWQTPLHIAA-----------ANKAVKCAEALVPLLSNVNVS 136 Query: 493 D-----------------TIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLEL 535 D +K L+ GA + A D+K R A+H AA ++E+++L + Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD-RRAIHWAAYMGHIEVVKLLVSH 195 Query: 536 PSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 + ++ + K+Y T LH AAS + V+ L+ G D + N P+H+ Sbjct: 196 GAEVTCKDKKSY---TPLHAAAS----SGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245 Score = 44.7 bits (104), Expect = 3e-04 Identities = 66/288 (22%), Positives = 121/288 (42%), Gaps = 38/288 (13%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH+A G S + +++ +D + G++ A A + L+N GA N Sbjct: 376 LHLAALSG---FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432 Query: 408 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV-DLEATNYDGLTPLHCAVIAH--- 463 D +GR+PLH A + Q L A+ VGS V DL+ G TPLH A + Sbjct: 433 KKDKFGRSPLHYAAANCNYQCLFAL----VGSGASVNDLDER---GCTPLHYAATSDTDG 485 Query: 464 NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAA---------------VEAK 508 + + L+ + P + Q + S + +Q+ A+ + Sbjct: 486 KCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDS 545 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 D ++ + LHLAA + + + + ++ L ++ + +G T L +AA + ++ Sbjct: 546 DNRATISPLHLAAYHGHHQALEVLVQ---SLLDLDVRNSSGRTPLDLAAFKGH----VEC 598 Query: 569 VRLLMRKGADPSTRN-LENEQPVHLVPDGPVGEQIRRILKGKSIQQRA 615 V +L+ +GA ++ + P+H E + R+L G + Q A Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECL-RLLIGNAEPQNA 645 Score = 38.9 bits (89), Expect = 0.014 Identities = 23/93 (24%), Positives = 44/93 (47%) Query: 329 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 L + + + +D +T LH+A ++G + ++ K+ ++++ Q+ VA Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAA 934 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCA 421 ++VQ+L+ GA V D G TP CA Sbjct: 935 RNGLTMVVQELLGKGASVLAVDENGYTPALACA 967 >gi|41327754 ankyrin repeat domain 3 [Homo sapiens] Length = 784 Score = 71.2 bits (173), Expect = 3e-12 Identities = 108/421 (25%), Positives = 157/421 (37%), Gaps = 92/421 (21%) Query: 214 PIPPQSPAYEPNLFDGPESQFCPNQSLVSLLG--DQRESENIANPMQTSSSVQQQNDAHL 271 P P+S L F + SL LL D S+ + P + S S + Sbjct: 306 PPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSE------ 359 Query: 272 HSFSMMPSSACEAMVGHEMASDS---SNTSLPFSNMGNPMNTTQLG------KSLFQWQV 322 S +PSS + + DS S SL S P +T+ LG K L V Sbjct: 360 ---SKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREP-STSDLGTTDVQKKKLVDAIV 415 Query: 323 EQEESKLANISQDQFLSKDAD-GDTFLHIAVAQGRRALSYVLA-----------RKMNAL 370 + SKL I Q Q + D G + LH+AV G+ + L R L Sbjct: 416 SGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475 Query: 371 HM-------------------LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDC 411 HM ++ K+ + +A A + L+ A VN D Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535 Query: 412 WGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQ 471 GRTP+HV + G +++ + + + VD+ D PLH A Sbjct: 536 EGRTPMHVACQHGQENIVRILLR------RGVDVSLQGKDAWLPLHYAA----------- 578 Query: 472 RNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRL 531 Q H P + +LL K Q G +V A+ GRT LHLAA+ + + R+ Sbjct: 579 --WQGHLP-IVKLLAK------------QPGVSVNAQ-TLDGRTPLHLAAQRGHYRVARI 622 Query: 532 FLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVH 591 ++L S VN + T LHVAA + T RLL+ +GA + +H Sbjct: 623 LIDL---CSDVNVCSLLAQTPLHVAAETGHTST----ARLLLHRGAGKEAMTSDGYTALH 675 Query: 592 L 592 L Sbjct: 676 L 676 Score = 66.6 bits (161), Expect = 6e-11 Identities = 74/267 (27%), Positives = 116/267 (43%), Gaps = 25/267 (9%) Query: 303 NMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLS---KDADGDTFLHIAVAQGRRAL 359 N NP + + G + VE+ + + + +S KD D T LH A G + Sbjct: 460 NNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESS 519 Query: 360 SYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTT--DCWGRTPL 417 + +L K +++ +D + G++ VA Q IV+ L+ G V+ D W PL Sbjct: 520 TRLLLEKNASVNEVDFE---GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAW--LPL 574 Query: 418 HVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHN----AVVHELQRN 473 H A +GH +++ + K V + A DG TPLH A + ++ +L + Sbjct: 575 HYAAWQGHLPIVKLLAK-----QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629 Query: 474 QQPHSPEVQELL--LKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRL 531 S Q L T + L+ GA EA G TALHLAA +L ++L Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT-SDGYTALHLAARNGHLATVKL 688 Query: 532 FLELPSCLSFVNAKAYNGNTALHVAAS 558 +E + V A+ TALH+AA+ Sbjct: 689 LVEEK---ADVLARGPLNQTALHLAAA 712 Score = 33.5 bits (75), Expect = 0.60 Identities = 33/121 (27%), Positives = 54/121 (44%), Gaps = 12/121 (9%) Query: 346 TFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI-VQDLVNIGA 404 T LH+A G + + +L + + +G +A +A A N HL V+ LV A Sbjct: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMT---SDGYTALHLA-ARNGHLATVKLLVEEKA 694 Query: 405 QVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHN 464 V +T LH+ A GHS+V++ + V ++ + GL+ LH A + Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-------IDLFDEQGLSALHLAAQGRH 747 Query: 465 A 465 A Sbjct: 748 A 748 >gi|157743284 ankyrin repeat domain 52 [Homo sapiens] Length = 1076 Score = 69.3 bits (168), Expect = 1e-11 Identities = 80/290 (27%), Positives = 126/290 (43%), Gaps = 49/290 (16%) Query: 339 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 398 ++D T LH+A A + LA +++L++ D +G+SA AV + V Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD---RSGRSALHHAVHSGHLETVNL 158 Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-----------QKG------AVGSNQ 441 L+N GA +N D R PLH A GH +VL+ + +KG A S Q Sbjct: 159 LLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ 218 Query: 442 F----------VDLEATNYDGLTPLHCA-VIAHNAVVHEL--------QRNQQPHSPEVQ 482 +++ N G T LH A + +AV EL Q N + +P Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHV 278 Query: 483 ELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFV 542 + N +L ++ L+ GA V + K G++ LH+AA ++ ++ S + Sbjct: 279 AAVSTNGAL--CLELLVNNGADVNYQS-KEGKSPLHMAAIHGRFTRSQILIQNG---SEI 332 Query: 543 NAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 + GNT LHVAA + L + LM GAD + R + + P+HL Sbjct: 333 DCADKFGNTPLHVAARYGHEL----LISTLMTNGADTARRGIHDMFPLHL 378 Score = 62.8 bits (151), Expect = 9e-10 Identities = 70/261 (26%), Positives = 114/261 (43%), Gaps = 23/261 (8%) Query: 341 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 400 DA G T L +A+ G ++L K + D++ G++A + L+ Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR---GRTALHRGAVTGCEDCLAALL 741 Query: 401 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEA-TNYDGLTPLHCA 459 + A V D GRTP+H+ + GH+ VL+ + + A+ ++ L+A +Y G +P+H A Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTD---PLDAGVDYSGYSPMHWA 798 Query: 460 VIAHNAVVHELQRNQQPHS-------PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 512 + EL P S + ++ N+ T L +GA + Sbjct: 799 SYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDST-TEMLLGALGAKIVNSRDAK 857 Query: 513 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 572 GRT LH AA N+ +R+ L+ + VNA + G TAL AA Q AV L Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQHQ---AEVNATDHTGRTALMTAA----ENGQTAAVEFL 910 Query: 573 MRKG-ADPSTRNLENEQPVHL 592 + +G AD + + +HL Sbjct: 911 LYRGKADLTVLDENKNTALHL 931 Score = 58.9 bits (141), Expect = 1e-08 Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 45/235 (19%) Query: 348 LHIAVAQG-----RRALS----YVLARKMNALHML------DIKEHNGQSAFQVAVAANQ 392 LH+AV G R+ LS Y + ++ H+L + ++ G++ A + Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435 Query: 393 HLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDG 452 + L++ GA + D +GRTPLH A G Q + G N+ + G Sbjct: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE------ADCKG 489 Query: 453 LTPLHCAVIAHNAVVHELQRNQQPHSP-----EVQELL--LKNKSLVDTIKCLIQMGAAV 505 +PLH A + + R +PH+P E E L + K ++ L+ GA Sbjct: 490 CSPLHYAAAS------DTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADP 543 Query: 506 EAKDRKSGRTALHLAAEEANLELIRLFLELP-SCLSFVNA---------KAYNGN 550 +DR+ G TA+H AA N + + L LE+ +CL V + AYNG+ Sbjct: 544 SLRDRQ-GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597 Score = 54.3 bits (129), Expect = 3e-07 Identities = 77/300 (25%), Positives = 123/300 (41%), Gaps = 53/300 (17%) Query: 313 LGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHM 372 L +++F VE+ S L+ L D + T LH A G + +L M+ ++ Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVL--DQERRTPLHAAAYVGDVPILQLLL--MSGANV 67 Query: 373 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 432 + K+ + A A+ ++ L+ A VN D +TPLHV A ++ +A+ Sbjct: 68 -NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126 Query: 433 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSL- 491 + L + G + LH AV H V LL K SL Sbjct: 127 ------APLLSSLNVADRSGRSALHHAV-------------HSGHLETVNLLLNKGASLN 167 Query: 492 ------------------VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFL 533 ++ +K L+ GA + KDRK G LH AA +E+++ L Sbjct: 168 VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK-GYGLLHTAAASGQIEVVKYLL 226 Query: 534 ELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL-LMRKGADPSTRNLENEQPVHL 592 + + + NA GNTALH+A L DAV + L+ GA+ + N + P+H+ Sbjct: 227 RMGAEIDEPNA---FGNTALHIACYLGQ-----DAVAIELVNAGANVNQPNDKGFTPLHV 278 Score = 53.1 bits (126), Expect = 7e-07 Identities = 55/218 (25%), Positives = 91/218 (41%), Gaps = 20/218 (9%) Query: 396 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTP 455 V+ L++ +N D RTPLH A G +LQ + N A + LTP Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN------AKDTLWLTP 77 Query: 456 LHCAVIAHNAVV------HELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 509 LH A + N V H N + + + + L + +++ D Sbjct: 78 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137 Query: 510 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 569 R SGR+ALH A +LE + L L + L+ + K LH AA L + L+ + Sbjct: 138 R-SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE---RQPLHWAAFLGH----LEVL 189 Query: 570 RLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 607 +LL+ +GAD ++ + +H E ++ +L+ Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227 Score = 50.1 bits (118), Expect = 6e-06 Identities = 70/296 (23%), Positives = 108/296 (36%), Gaps = 60/296 (20%) Query: 344 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 403 G T LH+A AL L A KE G+S +A + Q L+ G Sbjct: 272 GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE--GKSPLHMAAIHGRFTRSQILIQNG 329 Query: 404 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV--- 460 ++++ D +G TPLHV A GH ++ + D + PLH AV Sbjct: 330 SEIDCADKFGNTPLHVAARYGHELLISTLMTNGA------DTARRGIHDMFPLHLAVLFG 383 Query: 461 -----------------IAHNAVVHELQRNQQPHSPE-VQELLLKNKSLVDTIKCL---I 499 ++ + H L ++P+ + L + ++CL + Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALH-VAAS 558 GA + +D K GRT LH AA + + + L + + VN G + LH AAS Sbjct: 444 SSGADLRRRD-KFGRTPLHYAAANGSYQCA---VTLVTAGAGVNEADCKGCSPLHYAAAS 499 Query: 559 LQYRLTQ-----------------------LDAVRLLMRKGADPSTRNLENEQPVH 591 YR + + L+ GADPS R+ + VH Sbjct: 500 DTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555 Score = 49.7 bits (117), Expect = 8e-06 Identities = 56/219 (25%), Positives = 98/219 (44%), Gaps = 17/219 (7%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH+A G LA L LD+++H G++A +A V+ L GA Sbjct: 589 LHLAAYNGHCEALKTLAE---TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645 Query: 408 TTDCWGR-TPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL-EATNYDGLTPLHCAVI-AHN 464 + + TPLH A GH+ L + + S + D+ + + G TPL A++ H Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLL----IDSGERADITDVMDAYGQTPLMLAIMNGHV 701 Query: 465 AVVH-ELQRNQQPHSPEVQELLLKNKSLV----DTIKCLIQMGAAVEAKDRKSGRTALHL 519 VH L++ + +++ ++ V D + L+ A V +D K GRT +HL Sbjct: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFK-GRTPIHL 760 Query: 520 AAEEANLELIRLFLELPSCLSFVNAKA-YNGNTALHVAA 557 A+ + ++R L+ ++A Y+G + +H A+ Sbjct: 761 ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS 799 Score = 48.5 bits (114), Expect = 2e-05 Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 18/201 (8%) Query: 399 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 458 L++ GA + D G T +H A G+ Q L+ + + + N D+E+T ++PLH Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE--MSFNCLEDVESTI--PVSPLHL 591 Query: 459 AVIAHNAVVHELQR--------NQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDR 510 A A+N L+ + + H L + + ++ L GA+ K+R Sbjct: 592 A--AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649 Query: 511 KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR 570 K T LH AA + + + L ++ + G T L +A + +D V Sbjct: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGH----VDCVH 705 Query: 571 LLMRKGADPSTRNLENEQPVH 591 LL+ KG+ +L +H Sbjct: 706 LLLEKGSTADAADLRGRTALH 726 Score = 48.1 bits (113), Expect = 2e-05 Identities = 69/291 (23%), Positives = 116/291 (39%), Gaps = 18/291 (6%) Query: 325 EESKLANISQDQF-LSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIK-EHNGQS 382 E+ A + D F L +D G T +H+A A G A+ L + + LD +++G S Sbjct: 734 EDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793 Query: 383 AFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQF 442 A + H +L+ + + + TPLH CA + + GA+G+ Sbjct: 794 PMHWA-SYTGHEDCLELLLEHSPFSYLEGNPFTPLH-CAVINNQDSTTEMLLGALGAKIV 851 Query: 443 VDLEATNYDGLTPLHCAVIAHNA------VVHELQRNQQPHSPEVQELLLKNKSLVDTIK 496 +A G TPLH A A N + H+ + N H+ + ++ Sbjct: 852 NSRDAK---GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE 908 Query: 497 CLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVA 556 L+ G A ++ TALHLA + + + + L L +NA N+AL + Sbjct: 909 FLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINAT----NSALQMP 964 Query: 557 ASLQYRLTQLDAVRLLMRKGADPSTRNLENEQP-VHLVPDGPVGEQIRRIL 606 + R V+ L+ GA + E P + P+ V + + IL Sbjct: 965 LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015 >gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [Homo sapiens] Length = 1327 Score = 68.9 bits (167), Expect = 1e-11 Identities = 77/296 (26%), Positives = 123/296 (41%), Gaps = 50/296 (16%) Query: 340 KDADG--DTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQ 397 +D +G T LH A R ++ L +H K+ G A + + + + Sbjct: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA---KDKGGLVPLHNACSYGHYEVAE 734 Query: 398 DLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 457 LV GA VN D W TPLH A KG ++ + + K D N DG TPL Sbjct: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGA------DPTKKNRDGNTPLD 788 Query: 458 CAV------------------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLV------- 492 A + +Q+ P + ++ +N + + Sbjct: 789 LVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYN 848 Query: 493 --DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 550 + + L++ GA V A+D K G LH AA ++++ L ++ +C++ + A+ Sbjct: 849 NLEVAEYLLEHGADVNAQD-KGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAF--- 904 Query: 551 TALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 606 T LH AA Q TQL A LL+ GADP+ +N E + P+ L + IR +L Sbjct: 905 TPLHEAA--QKGRTQLCA--LLLAHGADPTMKNQEGQTPLDLA----TADDIRALL 952 Score = 65.9 bits (159), Expect = 1e-10 Identities = 83/296 (28%), Positives = 119/296 (40%), Gaps = 46/296 (15%) Query: 348 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 407 LH A GR+ + L + +H D G A + +V L+ GA N Sbjct: 220 LHFAAGFGRKDVVEHLLQMGANVHARD---DGGLIPLHNACSFGHAEVVSLLLCQGADPN 276 Query: 408 TTDCWGRTPLHVCAEKGHSQV-LQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAV 466 D W TPLH A KG V + +Q GA D N DG + L A + AV Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGA-------DPNIRNTDGKSALDLADPSAKAV 329 Query: 467 V-------HELQRNQQPHSPEVQELLL------------KNKSL--------VDTIKCLI 499 + L+ + + ++ LL K+ L V ++ L+ Sbjct: 330 LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLL 389 Query: 500 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 559 Q GA V AKD K G LH A + E+ L L+ +C VNA T LH AAS Sbjct: 390 QHGADVHAKD-KGGLVPLHNACSYGHYEVTELLLKHGAC---VNAMDLWQFTPLHEAASK 445 Query: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRA 615 +++ LL+ GADP+ N + V + P + E++ KG S+ Q A Sbjct: 446 N----RVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAA 497 Score = 56.2 bits (134), Expect = 9e-08 Identities = 79/332 (23%), Positives = 136/332 (40%), Gaps = 55/332 (16%) Query: 314 GKSLFQWQVEQEESKLANISQDQFLS--KDADGDTFLHIAVAQ---GRRALSYVLARKMN 368 G SL Q E + +K+ + ++ + +T LH AVA R+ ++ +L RK Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549 Query: 369 ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQV 428 ++ K + + VA + +++ L GA++N D G+T LH A GH Q Sbjct: 550 NVNE---KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT 606 Query: 429 LQ------------------AIQKGAVGSNQFVD--------------LEATNYDGLTPL 456 + A Q G Q + LEA+ L + Sbjct: 607 CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETV 666 Query: 457 HCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTA 516 + N +L+ HS + N+ V ++ L+ GA V AKD K G Sbjct: 667 KQLCSSQNVNCRDLEGR---HSTPLHFAAGYNR--VSVVEYLLHHGADVHAKD-KGGLVP 720 Query: 517 LHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKG 576 LH A + E+ L + + ++ + + T LH AA+ + + +LL++ G Sbjct: 721 LHNACSYGHYEVAELLVRHGASVNVADLWKF---TPLHEAAA----KGKYEICKLLLKHG 773 Query: 577 ADPSTRNLENEQPVHLVPDGPVGEQIRRILKG 608 ADP+ +N + P+ LV +G I+ +L+G Sbjct: 774 ADPTKKNRDGNTPLDLVKEGDT--DIQDLLRG 803 Score = 55.1 bits (131), Expect = 2e-07 Identities = 74/272 (27%), Positives = 116/272 (42%), Gaps = 30/272 (11%) Query: 329 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 388 LA+ S L+ + D L A + L +L H D ++ + +A Sbjct: 321 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRK---STPLHLAA 377 Query: 389 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 448 N+ IVQ L+ GA V+ D G PLH GH +V + + K N A Sbjct: 378 GYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN------AM 431 Query: 449 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAK 508 + TPLH A + V L + H + + KS VD M E + Sbjct: 432 DLWQFTPLHEAASKNRVEVCSLLLS---HGADPTLVNCHGKSAVD-------MAPTPELR 481 Query: 509 DRKS----GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVA-ASLQYRL 563 +R + G + L AA EA+L ++ L L ++F +++ TALH A ASL + Sbjct: 482 ERLTYEFKGHSLLQ-AAREADLAKVKKTLAL-EIINFKQPQSH--ETALHCAVASLHPKR 537 Query: 564 TQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 595 Q+ LL+RKGA+ + +N + P+H+ + Sbjct: 538 KQV--TELLLRKGANVNEKNKDFMTPLHVAAE 567 >gi|96975023 ankyrin repeat and death domain containing 1A [Homo sapiens] Length = 522 Score = 67.8 bits (164), Expect = 3e-11 Identities = 81/257 (31%), Positives = 108/257 (42%), Gaps = 33/257 (12%) Query: 343 DGDTFLHIAVAQGRRALSYVLARKMNALH--MLDIKEHNGQSAFQVAVAANQHLIVQDLV 400 DG T LH A +G VLA M L LD + G++AF A Q + LV Sbjct: 123 DGLTLLHCAAQKGHVP---VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLV 179 Query: 401 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 460 G N D G T LH+ A +GH VLQ + +G +DLE N +GLT LH A Sbjct: 180 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD--IG----LDLEEQNAEGLTALHSAA 233 Query: 461 -IAHNAVVHELQRNQQPHSPEVQELLLKNKSLV---------DTIKCLIQMGAAVEAKDR 510 +H V L R V L KN S + D + LI G D Sbjct: 234 GGSHPDCVQLLLR----AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDH 289 Query: 511 KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR 570 + G + LHLA L+RL + S VNA T LH+AA ++ D Sbjct: 290 Q-GASPLHLAVRHNFPALVRLLINSD---SDVNAVDNRQQTPLHLAAEHAWQ----DIAD 341 Query: 571 LLMRKGADPSTRNLENE 587 +L+ G D + R+ + + Sbjct: 342 MLLIAGVDLNLRDKQGK 358 Score = 58.9 bits (141), Expect = 1e-08 Identities = 67/263 (25%), Positives = 111/263 (42%), Gaps = 37/263 (14%) Query: 348 LHIAVAQGRRA-LSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQV 406 LH A Q + ++ R++N + H G+ A A A V+ L+ A V Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTR----ARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74 Query: 407 NTTD----------CWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL 456 + D C+G L + A GH ++LQ + N + + DGLT L Sbjct: 75 DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL------VNSGAKIHCESKDGLTLL 128 Query: 457 HCAVIAHNA-----VVHELQRNQQPHSPEVQELLLKNKS---LVDTIKCLIQMGAAVEAK 508 HCA + ++ +L+ H ++ + +D + L+ G K Sbjct: 129 HCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK 188 Query: 509 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 568 D K G TALHLAA ++ +++ +++ L NA+ G TALH AA + D Sbjct: 189 D-KEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE---GLTALHSAAGGSHP----DC 240 Query: 569 VRLLMRKGADPSTRNLENEQPVH 591 V+LL+R G+ + +N +H Sbjct: 241 VQLLLRAGSTVNALTQKNLSCLH 263 Score = 48.1 bits (113), Expect = 2e-05 Identities = 55/204 (26%), Positives = 89/204 (43%), Gaps = 22/204 (10%) Query: 340 KDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHN--GQSAFQVAVAANQHLIVQ 397 KD +G+T LH+A +G A VL R ++ LD++E N G +A A + VQ Sbjct: 188 KDKEGNTALHLAAGRGHMA---VLQRLVDI--GLDLEEQNAEGLTALHSAAGGSHPDCVQ 242 Query: 398 DLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 457 L+ G+ VN + LH A G V + + +N ++ G +PLH Sbjct: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCAN------VVDHQGASPLH 296 Query: 458 CAVIAHN--AVVHEL-----QRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDR 510 AV HN A+V L N + + L + D L+ G + +D Sbjct: 297 LAV-RHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRD- 354 Query: 511 KSGRTALHLAAEEANLELIRLFLE 534 K G+TAL +A ++ L+ + ++ Sbjct: 355 KQGKTALAVAVRSNHVSLVDMIIK 378 Score = 37.7 bits (86), Expect = 0.032 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 6/98 (6%) Query: 495 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALH 554 ++ L+ GA + + K G T LH AA++ ++ ++ +E ++ + G TA H Sbjct: 107 LQILVNSGAKIHCES-KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKL-GRTAFH 164 Query: 555 VAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 592 AA QLDA+ L+ G D + ++ E +HL Sbjct: 165 RAAEHG----QLDALDFLVGSGCDHNVKDKEGNTALHL 198 >gi|89363047 death-associated protein kinase 1 [Homo sapiens] Length = 1430 Score = 67.4 bits (163), Expect = 4e-11 Identities = 64/241 (26%), Positives = 98/241 (40%), Gaps = 42/241 (17%) Query: 373 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 432 LD+K+ +G+ A VA + Q L + G+ N D TPLH A G+ V +A+ Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497 Query: 433 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 492 + N N +G TPL L + Sbjct: 498 CEAGCNVN------IKNREGETPL---------------------------LTASARGYH 524 Query: 493 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 552 D ++CL + GA + A D K G ALHLA +E+I+ L C FV+ + +GNT Sbjct: 525 DIVECLAEHGADLNACD-KDGHIALHLAVRRCQMEVIKTLLS-QGC--FVDYQDRHGNTP 580 Query: 553 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRI-LKGKSI 611 LHVA + + V L + N P+HL + + + +R + L G S+ Sbjct: 581 LHVAC----KDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASV 636 Query: 612 Q 612 + Sbjct: 637 E 637 Score = 40.4 bits (93), Expect = 0.005 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 3/90 (3%) Query: 341 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 400 D DG LH+AV RR V+ ++ +D ++ +G + VA IV L Sbjct: 541 DKDGHIALHLAV---RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALC 597 Query: 401 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 430 ++ ++ +GRTPLH+ A G V++ Sbjct: 598 EANCNLDISNKYGRTPLHLAANNGILDVVR 627 >gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo sapiens] Length = 782 Score = 67.0 bits (162), Expect = 5e-11 Identities = 66/229 (28%), Positives = 100/229 (43%), Gaps = 24/229 (10%) Query: 372 MLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQA 431 +LD +G SA A +V+ LV GA VN D G TPLHV A G+ + + Sbjct: 93 VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152 Query: 432 IQK-----GAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL 486 + AV S+ + L+ D + L A IA V E + + +ELLL Sbjct: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAE------EELLL 206 Query: 487 KNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKA 546 + +C + GA EA+ ++G +ALH+AA + +E++RL L+ + Sbjct: 207 HDT------RCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDG-- 258 Query: 547 YNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 595 +G T LH AA DA RLL G + ++P L + Sbjct: 259 -DGWTPLHAAAHWGVE----DACRLLAEHGGGMDSLTHAGQRPCDLADE 302 Score = 43.1 bits (100), Expect = 8e-04 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 7/89 (7%) Query: 504 AVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRL 563 AV G +ALH A + NLE++R +E + VN G T LHVAAS Y Sbjct: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGAT---VNQADNEGWTPLHVAASCGY-- 146 Query: 564 TQLDAVRLLMRKGADPSTRNLENEQPVHL 592 LD R L+ GA+ + N + + P+ L Sbjct: 147 --LDIARYLLSHGANIAAVNSDGDLPLDL 173 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.129 0.376 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,863,505 Number of Sequences: 37866 Number of extensions: 1183237 Number of successful extensions: 6313 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 185 Number of HSP's successfully gapped in prelim test: 182 Number of HSP's that attempted gapping in prelim test: 4172 Number of HSP's gapped (non-prelim): 1178 length of query: 618 length of database: 18,247,518 effective HSP length: 108 effective length of query: 510 effective length of database: 14,157,990 effective search space: 7220574900 effective search space used: 7220574900 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.