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Search of human proteins with 53729325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|53729325 nuclear receptor subfamily 6, group A, member 1
isoform 1 [Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|53729325 nuclear receptor subfamily 6, group A, member 1 isof... 993 0.0
gi|53729327 nuclear receptor subfamily 6, group A, member 1 isof... 972 0.0
gi|45545405 nuclear receptor subfamily 5, group A, member 2 isof... 167 3e-41
gi|4504343 nuclear receptor subfamily 5, group A, member 2 isofo... 167 3e-41
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 157 3e-38
gi|20070193 nuclear receptor subfamily 5, group A, member 1 [Hom... 151 1e-36
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 122 7e-28
gi|11415052 retinoid X receptor, beta [Homo sapiens] 119 8e-27
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 115 7e-26
gi|19743907 RAR-related orphan receptor B [Homo sapiens] 115 1e-25
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 114 1e-25
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 112 6e-25
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 112 7e-25
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 112 7e-25
gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] 112 7e-25
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 111 2e-24
gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] 110 2e-24
gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] 110 3e-24
gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] 110 3e-24
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 110 3e-24
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 110 4e-24
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 108 1e-23
gi|27894359 nuclear receptor subfamily 4, group A, member 3 isof... 108 1e-23
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 108 1e-23
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 108 1e-23
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 107 2e-23
gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Hom... 105 7e-23
gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens] 103 3e-22
gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens] 103 3e-22
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 103 3e-22
>gi|53729325 nuclear receptor subfamily 6, group A, member 1 isoform
1 [Homo sapiens]
Length = 480
Score = 993 bits (2566), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTC 60
MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTC
Sbjct: 1 MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTC 60
Query: 61 LICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKC 120
LICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKC
Sbjct: 61 LICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKC 120
Query: 121 LQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSP 180
LQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSP
Sbjct: 121 LQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSP 180
Query: 181 GNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLP 240
GNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLP
Sbjct: 181 GNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLP 240
Query: 241 QQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIA 300
QQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIA
Sbjct: 241 QQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIA 300
Query: 301 WIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHR 360
WIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHR
Sbjct: 301 WIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHR 360
Query: 361 FSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWY 420
FSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWY
Sbjct: 361 FSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWY 420
Query: 421 ICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE 480
ICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE
Sbjct: 421 ICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE 480
>gi|53729327 nuclear receptor subfamily 6, group A, member 1 isoform
2 [Homo sapiens]
Length = 475
Score = 973 bits (2514), Expect = 0.0
Identities = 474/480 (98%), Positives = 475/480 (98%), Gaps = 5/480 (1%)
Query: 1 MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTC 60
MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGT +DRAEQRTC
Sbjct: 1 MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGT----NDRAEQRTC 56
Query: 61 LICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKC 120
LICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKC
Sbjct: 57 LICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKC 116
Query: 121 LQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSP 180
LQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSP
Sbjct: 117 LQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSP 176
Query: 181 GNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLP 240
GNRASESNQPSPGSTLSS RSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLP
Sbjct: 177 GNRASESNQPSPGSTLSS-RSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLP 235
Query: 241 QQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIA 300
QQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIA
Sbjct: 236 QQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIA 295
Query: 301 WIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHR 360
WIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHR
Sbjct: 296 WIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHR 355
Query: 361 FSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWY 420
FSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWY
Sbjct: 356 FSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWY 415
Query: 421 ICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE 480
ICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE
Sbjct: 416 ICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE 475
>gi|45545405 nuclear receptor subfamily 5, group A, member 2 isoform
1 [Homo sapiens]
Length = 541
Score = 167 bits (422), Expect = 3e-41
Identities = 118/446 (26%), Positives = 199/446 (44%), Gaps = 51/446 (11%)
Query: 48 ISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRK 107
++ S D + C +CGD+ +G HYG+++CE CKGFFKR++ N + Y C ++NC + +
Sbjct: 74 VNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKT 133
Query: 108 QRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPV----QISEEEIERIMSGQEFE 163
QR RC YCR KCL +GM +A+R D M GGRNK GP+ + +++ + ++ +
Sbjct: 134 QRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNK-FGPMYKRDRALKQQKKALIRANGLK 192
Query: 164 EEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELN-GFMAFREQYMGMSVPPH 222
EA + + + S G L+ + + F + M++PPH
Sbjct: 193 LEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPH 252
Query: 223 --------YQYIPHLFSYSGHSPLLPQQARSLDPQSY----------SLIHQLLSAEDLE 264
Y + P S + S+ SY S+ H +L E
Sbjct: 253 GSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCE 312
Query: 265 PLGTPMLIEDGYAVTQAE-----------LFALLCRLADELLFRQIAWIKKLPFFCELSI 313
P P + A Q E F L+C++AD+ LF + W + FF EL +
Sbjct: 313 P-DEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKV 371
Query: 314 KDYTCLLSSTWQELILLSSL---TVYSKQ-----IFGELADVTAKYSPSDEELHRFSDEG 365
D LL + W EL++L + V+ K+ + G+ D + S + L+
Sbjct: 372 DDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHA 431
Query: 366 MEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDF 425
E++ +L L+ E+ C+K + + D++ L + +E + ++ D+
Sbjct: 432 QELVAKL-------RSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDY 484
Query: 426 TEYKYTHQPNRFPDLMMCLPEIRYIA 451
T Y Q +F L++ LPEIR I+
Sbjct: 485 TMCNYPQQTEKFGQLLLRLPEIRAIS 510
>gi|4504343 nuclear receptor subfamily 5, group A, member 2 isoform
2 [Homo sapiens]
Length = 495
Score = 167 bits (422), Expect = 3e-41
Identities = 118/446 (26%), Positives = 199/446 (44%), Gaps = 51/446 (11%)
Query: 48 ISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRK 107
++ S D + C +CGD+ +G HYG+++CE CKGFFKR++ N + Y C ++NC + +
Sbjct: 28 VNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKT 87
Query: 108 QRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPV----QISEEEIERIMSGQEFE 163
QR RC YCR KCL +GM +A+R D M GGRNK GP+ + +++ + ++ +
Sbjct: 88 QRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNK-FGPMYKRDRALKQQKKALIRANGLK 146
Query: 164 EEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELN-GFMAFREQYMGMSVPPH 222
EA + + + S G L+ + + F + M++PPH
Sbjct: 147 LEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPH 206
Query: 223 --------YQYIPHLFSYSGHSPLLPQQARSLDPQSY----------SLIHQLLSAEDLE 264
Y + P S + S+ SY S+ H +L E
Sbjct: 207 GSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCE 266
Query: 265 PLGTPMLIEDGYAVTQAE-----------LFALLCRLADELLFRQIAWIKKLPFFCELSI 313
P P + A Q E F L+C++AD+ LF + W + FF EL +
Sbjct: 267 P-DEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKV 325
Query: 314 KDYTCLLSSTWQELILLSSL---TVYSKQ-----IFGELADVTAKYSPSDEELHRFSDEG 365
D LL + W EL++L + V+ K+ + G+ D + S + L+
Sbjct: 326 DDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHA 385
Query: 366 MEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDF 425
E++ +L L+ E+ C+K + + D++ L + +E + ++ D+
Sbjct: 386 QELVAKL-------RSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDY 438
Query: 426 TEYKYTHQPNRFPDLMMCLPEIRYIA 451
T Y Q +F L++ LPEIR I+
Sbjct: 439 TMCNYPQQTEKFGQLLLRLPEIRAIS 464
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 157 bits (396), Expect = 3e-38
Identities = 125/457 (27%), Positives = 191/457 (41%), Gaps = 104/457 (22%)
Query: 10 GGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRT-----CLICG 64
G GG GG ++ P +D+ A PG S ++ E+R C++CG
Sbjct: 7 GWGGPGGDTNGVDKAGGYPRA-----AEDDSAS-PPGAASDAEPGDEERPGLQVDCVVCG 60
Query: 65 DRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMG 124
D+++G HYG+ +CEGCK FFKRSI Y C +++C + + RN+CQYCRL KC ++G
Sbjct: 61 DKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVG 120
Query: 125 MNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRA 184
M ++A++ +P HS PG A
Sbjct: 121 MRKEAVQRGRIP----------------------------------------HSLPGAVA 140
Query: 185 SESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLPQQAR 244
+ S P PGS L++ S L P Q
Sbjct: 141 ASSGSP-PGSALAAVAS---------------------------------GGDLFPGQPV 166
Query: 245 SLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKK 304
S LI QLL AE P G A +C LA LLF + W +
Sbjct: 167 S------ELIAQLLRAEPY-PAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARH 219
Query: 305 LPFFCELSIKDYTCLLSSTWQELILL----SSLTVYSKQIFGELADVTAKYSP-SDEELH 359
PFF EL + D LL +W EL +L ++L +++ + LA +P + E
Sbjct: 220 APFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPL---LAAAGLHAAPMAAERAV 276
Query: 360 RFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYW 419
F D+ E++ K +L+V + EY C+KAI D GL+ + +E L ++
Sbjct: 277 AFMDQVRAFQEQV----DKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQ 332
Query: 420 YICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVN 456
++ +Y QP RF L++ LP +R + +++
Sbjct: 333 VALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLIS 369
>gi|20070193 nuclear receptor subfamily 5, group A, member 1 [Homo
sapiens]
Length = 461
Score = 151 bits (382), Expect = 1e-36
Identities = 118/443 (26%), Positives = 200/443 (45%), Gaps = 58/443 (13%)
Query: 51 SDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRN 110
S D C +CGD+ +G HYG+++CE CKGFFKR++ N + Y C+ ++C + + QR
Sbjct: 4 SYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRK 63
Query: 111 RCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWS 170
RC +CR KCL +GM +A+R D M GGRNK GP+ + +++ +++A +
Sbjct: 64 RCPFCRFQKCLTVGMRLEAVRADRMRGGRNK-FGPMYKRDRALKQ-------QKKAQIRA 115
Query: 171 NHGDSDHSSPGNRASESNQPSPGSTLSSS-RSVELNGFMA---------FREQYMGMSVP 220
N G + P P+P L S E G A F + M+VP
Sbjct: 116 N-GFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVP 174
Query: 221 -PHYQYIPHLF-SYSGHS--------------PLLP---QQARSLDPQSYSLIHQLLSAE 261
H +L+ ++ G + P LP + S P LI QLL E
Sbjct: 175 GAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLE 234
Query: 262 DLEPLGTPMLIEDGYAVT-----QAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDY 316
E ++ T Q F LLCR+AD+ + W ++ F EL + D
Sbjct: 235 PDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQ 294
Query: 317 TCLLSSTWQELILLSSL---TVYSKQ-----IFGELADVTAKYSPSDEELHRFSDEGMEV 368
LL + W EL++ + + K+ + G+ ++T + + LH E+
Sbjct: 295 MTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQEL 354
Query: 369 IERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEY 428
+ +L+ L++ +E+ C+K I + D++ L + ++ ++ D+T
Sbjct: 355 VLQLL-------ALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLC 407
Query: 429 KYTHQPNRFPDLMMCLPEIRYIA 451
Y H ++F L++CL E+R ++
Sbjct: 408 HYPHCGDKFQQLLLCLVEVRALS 430
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 122 bits (306), Expect = 7e-28
Identities = 101/389 (25%), Positives = 160/389 (41%), Gaps = 74/389 (19%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C++CGDRA+G HY ++CEGCKGFF+RSI VY+C NCVM R +CQ CRL K
Sbjct: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRK 186
Query: 120 CLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSS 179
C +MGM + + + +Q + + + + H D
Sbjct: 187 CKEMGMLAECL------------LTEIQCKSKRLRK------------NVKQHAD----- 217
Query: 180 PGNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLL 239
N+ S G L S + RE+ + P Q + H S + +
Sbjct: 218 -----QTVNEDSEGRDLRQVTSTT----KSCREK---TELTPDQQTLLHFIMDSYNKQRM 265
Query: 240 PQQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQI 299
PQ+ + ++ + SAE E F +L +A + +
Sbjct: 266 PQEITN------KILKEEFSAE--------------------ENFLILTEMATNHVQVLV 299
Query: 300 AWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELH 359
+ KKLP F L +D LL + E + L S +++K++ +D+ EE
Sbjct: 300 EFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLL-------EERI 352
Query: 360 RFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYW 419
R S E I + Y +LK++ EEYA + AI L+ D + + +E+L +
Sbjct: 353 RNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLL 412
Query: 420 YICQDFTEYKYTHQPNRFPDLMMCLPEIR 448
+ Q + P F L+ L E+R
Sbjct: 413 DVLQKLCKIHQPENPQHFACLLGRLTELR 441
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 119 bits (297), Expect = 8e-27
Identities = 71/189 (37%), Positives = 92/189 (48%), Gaps = 33/189 (17%)
Query: 12 GGGGGSAGFLEPPAA------LPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGD 65
GGG G ++PP PPPP PG A +R C ICGD
Sbjct: 170 GGGSGPPEDVKPPVLGVRGLHCPPPPGG-----------PG--------AGKRLCAICGD 210
Query: 66 RATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGM 125
R++G HYG+ SCEGCKGFFKR+I Y C +K+C + ++QRNRCQYCR KCL GM
Sbjct: 211 RSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGM 270
Query: 126 NRKAIREDGMPG----GRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPG 181
R+A++E+ G G + G E ++RI+ E E S+ G G
Sbjct: 271 KREAVQEERQRGKDKDGDGEGAGGAP-EEMPVDRIL---EAELAVEQKSDQGVEGPGGTG 326
Query: 182 NRASESNQP 190
S N P
Sbjct: 327 GSGSSPNDP 335
Score = 77.0 bits (188), Expect = 3e-14
Identities = 49/171 (28%), Positives = 86/171 (50%), Gaps = 11/171 (6%)
Query: 287 LCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELAD 346
+C+ AD+ LF + W K++P F L + D LL + W EL L++S + S + +
Sbjct: 339 ICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNEL-LIASFSHRSIDVRDGILL 397
Query: 347 VTAKYSPSDEELHRFSDEGMEV---IERLIY-LYHKFHQLKVSNEEYACMKAINFLNQDI 402
T + +HR S V +R++ L K +++ E C++AI N D
Sbjct: 398 ATGLH------VHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDA 451
Query: 403 RGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGK 453
+GL++ S++E L ++ + + + + KY Q RF L++ LP +R I K
Sbjct: 452 KGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLK 502
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 115 bits (289), Expect = 7e-26
Identities = 54/126 (42%), Positives = 76/126 (60%), Gaps = 4/126 (3%)
Query: 9 SGGGGGGGSAGFLEP-PAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGDRA 67
+GG G F P PA+L +E+ P + S + C +C D++
Sbjct: 30 TGGSCFAGLESFAWPQPASLQSVETQSTSSEEMV---PSSPSPPPPPRVYKPCFVCNDKS 86
Query: 68 TGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNR 127
+G HYG+ SCEGCKGFF+RSI VY C RDKNC++++ RNRCQYCRL KC ++GM++
Sbjct: 87 SGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSK 146
Query: 128 KAIRED 133
+A+R D
Sbjct: 147 EAVRND 152
Score = 38.5 bits (88), Expect = 0.014
Identities = 33/165 (20%), Positives = 77/165 (46%), Gaps = 6/165 (3%)
Query: 290 LADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTA 349
LA + + + + + K+LP F LSI D LL + ++++L T Y+ + + +
Sbjct: 222 LATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPE--QDTMTFSD 279
Query: 350 KYSPSDEELHRFSDEGMEVIERLIYLY-HKFHQLKVSNEEYACMKAINFLNQDIRGLTSA 408
+ + ++H + G + L++ + + L++ + E + AI + D L
Sbjct: 280 GLTLNRTQMH---NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEP 336
Query: 409 SQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGK 453
++++L + + + + QP FP ++M + ++R I+ K
Sbjct: 337 EKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK 381
>gi|19743907 RAR-related orphan receptor B [Homo sapiens]
Length = 459
Score = 115 bits (287), Expect = 1e-25
Identities = 103/404 (25%), Positives = 173/404 (42%), Gaps = 60/404 (14%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C ICGD+++G+HYG+I+CEGCKGFF+RS N Y C R +NC++ R RNRCQ+CRL K
Sbjct: 10 CKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQK 69
Query: 120 CLQMGMNRKAIREDGMPGGRNKSI-GPVQISEEEIERIMSGQEFEEEA------------ 166
CL +GM+R A++ M + S+ VQ ++ ++ Q E EA
Sbjct: 70 CLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNG 129
Query: 167 -----NHWSNHGDSDH-----SSPGNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMG 216
N S + H S G +S QPSP + +++ G +++
Sbjct: 130 LSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQS-----GLDMTGIKQIKQE--- 181
Query: 217 MSVPPHYQY--IPHLFSYSGHSPLLPQQARSLDPQSYSLIHQLLSAEDLEPLGTPM--LI 272
P Y +P+LF+YS + Q A + I Q + LE M L
Sbjct: 182 ----PIYDLTSVPNLFTYSSFNN--GQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELH 235
Query: 273 EDGYAVTQAELFALLCRLADELLFRQIA------------WIKKLPFFCELSIKDYTCLL 320
+ + E + E L++Q A + K++ F EL D LL
Sbjct: 236 QLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLL 295
Query: 321 SSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHK-F 379
S E++L+ ++ + T + + F G + + + + K
Sbjct: 296 KSGCLEVVLVRMCRAFNP------LNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL 349
Query: 380 HQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQ 423
L+++ EE A + ++ D L ++++L ++ ++ Q
Sbjct: 350 CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQ 393
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 114 bits (286), Expect = 1e-25
Identities = 60/149 (40%), Positives = 80/149 (53%), Gaps = 25/149 (16%)
Query: 10 GGGGGGGSAGFL---------EPPAALPPPPRNGFCQD----ELAELDPGTISVSDDRAE 56
G G G AGF PP + P G Q E+A L T S S +
Sbjct: 15 GPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMV 74
Query: 57 Q------------RTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVM 104
+ C +C D+++G HYG+ SCEGCKGFF+RSI VY C RDKNC++
Sbjct: 75 PSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCII 134
Query: 105 SRKQRNRCQYCRLLKCLQMGMNRKAIRED 133
++ RNRCQYCRL KC ++GM+++A+R D
Sbjct: 135 NKVTRNRCQYCRLQKCFEVGMSKEAVRND 163
Score = 38.5 bits (88), Expect = 0.014
Identities = 33/165 (20%), Positives = 77/165 (46%), Gaps = 6/165 (3%)
Query: 290 LADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTA 349
LA + + + + + K+LP F LSI D LL + ++++L T Y+ + + +
Sbjct: 233 LATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPE--QDTMTFSD 290
Query: 350 KYSPSDEELHRFSDEGMEVIERLIYLY-HKFHQLKVSNEEYACMKAINFLNQDIRGLTSA 408
+ + ++H + G + L++ + + L++ + E + AI + D L
Sbjct: 291 GLTLNRTQMH---NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEP 347
Query: 409 SQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGK 453
++++L + + + + QP FP ++M + ++R I+ K
Sbjct: 348 EKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK 392
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 112 bits (281), Expect = 6e-25
Identities = 63/162 (38%), Positives = 89/162 (54%), Gaps = 15/162 (9%)
Query: 7 PPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELD--PGT-----ISVSDDRAEQRT 59
PPSG + PP++ + +++ L PG S S +
Sbjct: 79 PPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHI 138
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C ICGDR++G HYG+ SCEGCKGFFKR+I +Y C +K+C++ ++QRNRCQYCR K
Sbjct: 139 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQK 198
Query: 120 CLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQE 161
CL MGM R+A++E+ R +S + +E E E SG E
Sbjct: 199 CLVMGMKREAVQEE-----RQRS---RERAESEAECATSGHE 232
Score = 85.5 bits (210), Expect = 1e-16
Identities = 50/171 (29%), Positives = 90/171 (52%), Gaps = 11/171 (6%)
Query: 287 LCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELAD 346
+C AD+ LF + W K++P F +L+++D LL + W EL L++S + S + +
Sbjct: 269 ICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNEL-LIASFSHRSVSVQDGILL 327
Query: 347 VTAKYSPSDEELHRFSDEGM---EVIERLIY-LYHKFHQLKVSNEEYACMKAINFLNQDI 402
T + +HR S + +R++ L K +++ E C++AI N D
Sbjct: 328 ATGLH------VHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDA 381
Query: 403 RGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGK 453
+GL++ S++E L ++ + + +T+ KY QP RF L++ LP +R I K
Sbjct: 382 KGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLK 432
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 112 bits (280), Expect = 7e-25
Identities = 57/150 (38%), Positives = 81/150 (54%), Gaps = 29/150 (19%)
Query: 13 GGGGSAGFLEPPAA---------LPPPPRNGFCQDEL-----AELDPGTISVSDDRAEQ- 57
GGG G+ PP A L PP Q +L + P TI +E+
Sbjct: 12 GGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEI 71
Query: 58 --------------RTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCV 103
+ C +C D+++G HYG+ +CEGCKGFF+RSI VY C RDKNC+
Sbjct: 72 VPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCI 131
Query: 104 MSRKQRNRCQYCRLLKCLQMGMNRKAIRED 133
+++ RNRCQYCRL KC ++GM+++++R D
Sbjct: 132 INKVTRNRCQYCRLQKCFEVGMSKESVRND 161
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 112 bits (280), Expect = 7e-25
Identities = 57/150 (38%), Positives = 81/150 (54%), Gaps = 29/150 (19%)
Query: 13 GGGGSAGFLEPPAA---------LPPPPRNGFCQDEL-----AELDPGTISVSDDRAEQ- 57
GGG G+ PP A L PP Q +L + P TI +E+
Sbjct: 12 GGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEI 71
Query: 58 --------------RTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCV 103
+ C +C D+++G HYG+ +CEGCKGFF+RSI VY C RDKNC+
Sbjct: 72 VPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCI 131
Query: 104 MSRKQRNRCQYCRLLKCLQMGMNRKAIRED 133
+++ RNRCQYCRL KC ++GM+++++R D
Sbjct: 132 INKVTRNRCQYCRLQKCFEVGMSKESVRND 161
>gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens]
Length = 523
Score = 112 bits (280), Expect = 7e-25
Identities = 110/451 (24%), Positives = 187/451 (41%), Gaps = 61/451 (13%)
Query: 10 GGGGGGGSAGFLEPPA-------ALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLI 62
G G +AG E P + PP P + T + E C I
Sbjct: 16 GSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKI 75
Query: 63 CGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQ 122
CGD+++G+HYG+I+CEGCKGFF+RS + Y C R KNC++ R RNRCQ+CRL KCL
Sbjct: 76 CGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLA 135
Query: 123 MGMNRKAIREDGMPGGRNKSIGPVQISEEEIER-------------------IMSGQEFE 163
+GM+R A++ M + S+ ++ + +++ +S
Sbjct: 136 VGMSRDAVKFGRMSKKQRDSL-YAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLT 194
Query: 164 EEANHWSNHGDSDHSSPGNRASES-------NQPSPGSTLSSSRSVELNGFMAFREQYMG 216
E + SN+ D H+ G++A + QPSP + +++NG +
Sbjct: 195 ELHDDLSNYIDG-HTPEGSKADSAVSSFYLDIQPSPDQS-----GLDINGI----KPEPI 244
Query: 217 MSVPPHYQYIPHL-FSYSGHSPLLPQQARSLDPQSYSLIH----QLLSAEDLEPLGTPML 271
P + P+ F+ SP + Q+ S H Q L E+L+ +
Sbjct: 245 CDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYL-REELQQITWQTF 303
Query: 272 IE---DGYAVTQAELFALLCRL-ADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQEL 327
++ + Y Q E+ LC + E + + + K++ F EL D LL + E+
Sbjct: 304 LQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEV 363
Query: 328 ILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHK-FHQLKVSN 386
+ + + Q KY+ D F G E ++ + K + ++
Sbjct: 364 VFIRMCRAFDSQ--NNTVYFDGKYASPDV----FKSLGCEDFISFVFEFGKSLCSMHLTE 417
Query: 387 EEYACMKAINFLNQDIRGLTSASQLEQLNKR 417
+E A A ++ D L ++E+L ++
Sbjct: 418 DEIALFSAFVLMSADRSWLQEKVKIEKLQQK 448
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 111 bits (277), Expect = 2e-24
Identities = 51/105 (48%), Positives = 71/105 (67%), Gaps = 4/105 (3%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C ICGDR++G HYG+ SCEGCKGFFKR++ Y C +K+C++ ++QRNRCQYCR K
Sbjct: 135 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQK 194
Query: 120 CLQMGMNRKAIREDGMPG-GRNKSIGPVQISEEE---IERIMSGQ 160
CL MGM R+A++E+ G RN++ S E +ERI+ +
Sbjct: 195 CLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAE 239
Score = 80.9 bits (198), Expect = 2e-15
Identities = 50/171 (29%), Positives = 89/171 (52%), Gaps = 11/171 (6%)
Query: 287 LCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELAD 346
+C+ AD+ LF + W K++P F EL + D LL + W EL L++S + S + +
Sbjct: 268 ICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNEL-LIASFSHRSIAVKDGILL 326
Query: 347 VTAKYSPSDEELHRFSDEGMEV---IERLIY-LYHKFHQLKVSNEEYACMKAINFLNQDI 402
T + +HR S V +R++ L K +++ E C++AI N D
Sbjct: 327 ATGLH------VHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDS 380
Query: 403 RGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGK 453
+GL++ +++E L ++ + + + ++KY QP RF L++ LP +R I K
Sbjct: 381 KGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLK 431
>gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens]
Length = 556
Score = 110 bits (276), Expect = 2e-24
Identities = 104/419 (24%), Positives = 182/419 (43%), Gaps = 57/419 (13%)
Query: 35 FCQDELAELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVY 94
+ Q E E+ G ++ + E C ICGD+++G+HYG+I+CEGCKGFF+RS + Y
Sbjct: 84 YSQKEDKEVQTGYMNA---QIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATY 140
Query: 95 RCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIE 154
C R KNC++ R RNRCQ+CRL KCL +GM+R A++ M + S+ ++ + ++
Sbjct: 141 SCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSL-YAEVQKHRMQ 199
Query: 155 R-------------------IMSGQEFEEEANHWSNHGDSDHSSPGNRASES-------N 188
+ +S E + SN+ D H+ G++A +
Sbjct: 200 QQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDG-HTPEGSKADSAVSSFYLDI 258
Query: 189 QPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHL-FSYSGHSPLLPQQARSLD 247
QPSP + +++NG + P + P+ F+ SP +
Sbjct: 259 QPSPDQS-----GLDINGI----KPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHL 309
Query: 248 PQSYSLIH----QLLSAEDLEPLGTPMLIE---DGYAVTQAELFALLCRL-ADELLFRQI 299
Q+ S H Q L E+L+ + ++ + Y Q E+ LC + E + +
Sbjct: 310 AQNISKSHLETCQYL-REELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV 368
Query: 300 AWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELH 359
+ K++ F EL D LL + E++ + + Q KY+ D
Sbjct: 369 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQ--NNTVYFDGKYASPDV--- 423
Query: 360 RFSDEGMEVIERLIYLYHK-FHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKR 417
F G E ++ + K + ++ +E A A ++ D L ++E+L ++
Sbjct: 424 -FKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQK 481
>gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens]
Length = 468
Score = 110 bits (275), Expect = 3e-24
Identities = 99/394 (25%), Positives = 172/394 (43%), Gaps = 54/394 (13%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C ICGD+++G+HYG+I+CEGCKGFF+RS + Y C R KNC++ R RNRCQ+CRL K
Sbjct: 18 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQK 77
Query: 120 CLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIER-------------------IMSGQ 160
CL +GM+R A++ M + S+ ++ + +++ +S
Sbjct: 78 CLAVGMSRDAVKFGRMSKKQRDSL-YAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISAN 136
Query: 161 EFEEEANHWSNHGDSDHSSPGNRASES-------NQPSPGSTLSSSRSVELNGFMAFREQ 213
E + SN+ D H+ G++A + QPSP + +++NG +
Sbjct: 137 GLTELHDDLSNYIDG-HTPEGSKADSAVSSFYLDIQPSPDQS-----GLDINGI----KP 186
Query: 214 YMGMSVPPHYQYIPHL-FSYSGHSPLLPQQARSLDPQSYSLIH----QLLSAEDLEPLGT 268
P + P+ F+ SP + Q+ S H Q L E+L+ +
Sbjct: 187 EPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYL-REELQQITW 245
Query: 269 PMLIE---DGYAVTQAELFALLCRL-ADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTW 324
++ + Y Q E+ LC + E + + + K++ F EL D LL +
Sbjct: 246 QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS 305
Query: 325 QELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHK-FHQLK 383
E++ + + Q KY+ D F G E ++ + K +
Sbjct: 306 LEVVFIRMCRAFDSQ--NNTVYFDGKYASPDV----FKSLGCEDFISFVFEFGKSLCSMH 359
Query: 384 VSNEEYACMKAINFLNQDIRGLTSASQLEQLNKR 417
++ +E A A ++ D L ++E+L ++
Sbjct: 360 LTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQK 393
>gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens]
Length = 548
Score = 110 bits (275), Expect = 3e-24
Identities = 99/394 (25%), Positives = 172/394 (43%), Gaps = 54/394 (13%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C ICGD+++G+HYG+I+CEGCKGFF+RS + Y C R KNC++ R RNRCQ+CRL K
Sbjct: 98 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQK 157
Query: 120 CLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIER-------------------IMSGQ 160
CL +GM+R A++ M + S+ ++ + +++ +S
Sbjct: 158 CLAVGMSRDAVKFGRMSKKQRDSL-YAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISAN 216
Query: 161 EFEEEANHWSNHGDSDHSSPGNRASES-------NQPSPGSTLSSSRSVELNGFMAFREQ 213
E + SN+ D H+ G++A + QPSP + +++NG +
Sbjct: 217 GLTELHDDLSNYIDG-HTPEGSKADSAVSSFYLDIQPSPDQS-----GLDINGI----KP 266
Query: 214 YMGMSVPPHYQYIPHL-FSYSGHSPLLPQQARSLDPQSYSLIH----QLLSAEDLEPLGT 268
P + P+ F+ SP + Q+ S H Q L E+L+ +
Sbjct: 267 EPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYL-REELQQITW 325
Query: 269 PMLIE---DGYAVTQAELFALLCRL-ADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTW 324
++ + Y Q E+ LC + E + + + K++ F EL D LL +
Sbjct: 326 QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS 385
Query: 325 QELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHK-FHQLK 383
E++ + + Q KY+ D F G E ++ + K +
Sbjct: 386 LEVVFIRMCRAFDSQ--NNTVYFDGKYASPDV----FKSLGCEDFISFVFEFGKSLCSMH 439
Query: 384 VSNEEYACMKAINFLNQDIRGLTSASQLEQLNKR 417
++ +E A A ++ D L ++E+L ++
Sbjct: 440 LTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQK 473
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 110 bits (275), Expect = 3e-24
Identities = 45/92 (48%), Positives = 64/92 (69%)
Query: 42 ELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKN 101
EL P S + C +C D+++G HYG+ +CEGCKGFF+RSI +Y C RDKN
Sbjct: 63 ELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKN 122
Query: 102 CVMSRKQRNRCQYCRLLKCLQMGMNRKAIRED 133
CV+++ RNRCQYCRL KC ++GM+++++R D
Sbjct: 123 CVINKVTRNRCQYCRLQKCFEVGMSKESVRND 154
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 110 bits (274), Expect = 4e-24
Identities = 41/76 (53%), Positives = 60/76 (78%)
Query: 58 RTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRL 117
+ C +C D+++G HYG+ +CEGCKGFF+RSI VY C RDKNC++++ RNRCQYCRL
Sbjct: 81 KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRL 140
Query: 118 LKCLQMGMNRKAIRED 133
KC ++GM+++++R D
Sbjct: 141 QKCFEVGMSKESVRND 156
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 108 bits (269), Expect = 1e-23
Identities = 52/119 (43%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 23 PPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKG 82
PP L P P E L P S S E TC +CGD A HYG+ +CEGCKG
Sbjct: 268 PPLGLTPSPTASSLLGESPSL-PSPPSRSSSSGEG-TCAVCGDNAACQHYGVRTCEGCKG 325
Query: 83 FFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNK 141
FFKR++ Y C +KNC + +++RNRCQYCR KCL +GM ++ +R D + G R +
Sbjct: 326 FFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGR 384
>gi|27894359 nuclear receptor subfamily 4, group A, member 3 isoform
c [Homo sapiens]
Length = 443
Score = 108 bits (269), Expect = 1e-23
Identities = 52/119 (43%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 23 PPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKG 82
PP L P P E L P S S E TC +CGD A HYG+ +CEGCKG
Sbjct: 257 PPLGLTPSPTASSLLGESPSL-PSPPSRSSSSGEG-TCAVCGDNAACQHYGVRTCEGCKG 314
Query: 83 FFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNK 141
FFKR++ Y C +KNC + +++RNRCQYCR KCL +GM ++ +R D + G R +
Sbjct: 315 FFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGR 373
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 108 bits (269), Expect = 1e-23
Identities = 52/119 (43%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 23 PPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKG 82
PP L P P E L P S S E TC +CGD A HYG+ +CEGCKG
Sbjct: 257 PPLGLTPSPTASSLLGESPSL-PSPPSRSSSSGEG-TCAVCGDNAACQHYGVRTCEGCKG 314
Query: 83 FFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNK 141
FFKR++ Y C +KNC + +++RNRCQYCR KCL +GM ++ +R D + G R +
Sbjct: 315 FFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGR 373
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 108 bits (269), Expect = 1e-23
Identities = 52/119 (43%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 23 PPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKG 82
PP L P P E L P S S E TC +CGD A HYG+ +CEGCKG
Sbjct: 257 PPLGLTPSPTASSLLGESPSL-PSPPSRSSSSGEG-TCAVCGDNAACQHYGVRTCEGCKG 314
Query: 83 FFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNK 141
FFKR++ Y C +KNC + +++RNRCQYCR KCL +GM ++ +R D + G R +
Sbjct: 315 FFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGR 373
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 107 bits (267), Expect = 2e-23
Identities = 53/138 (38%), Positives = 72/138 (52%), Gaps = 7/138 (5%)
Query: 6 PPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISV-------SDDRAEQR 58
P GGGG AG + A P A PGT S +
Sbjct: 25 PAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHI 84
Query: 59 TCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLL 118
C++CGD+++G HYG +CEGCK FFKRS+ Y C ++NC + + RN+CQYCRL
Sbjct: 85 ECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLK 144
Query: 119 KCLQMGMNRKAIREDGMP 136
KCL++GM R+A++ MP
Sbjct: 145 KCLKVGMRREAVQRGRMP 162
Score = 85.9 bits (211), Expect = 7e-17
Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 6/171 (3%)
Query: 287 LCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSK-QIFGELA 345
+C LA LLF + W + +PFF +L I D LL TW EL +L++ + LA
Sbjct: 219 ICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLA 278
Query: 346 DVTAKYSP-SDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRG 404
SP S + + F D + + + + K L V + EY+C+KAI D G
Sbjct: 279 AAGLHASPMSADRVVAFMDH-IRIFQEQV---EKLKALHVDSAEYSCLKAIVLFTSDACG 334
Query: 405 LTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMV 455
L+ A+ +E L ++ +++ +Y +QP+RF L++ LP +R ++ ++
Sbjct: 335 LSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVI 385
>gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Homo
sapiens]
Length = 615
Score = 105 bits (263), Expect = 7e-23
Identities = 39/77 (50%), Positives = 59/77 (76%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C++CGD+A+G HYG +SCEGCKGFFKRS+ Y C +++C++++ RNRCQ+CRL K
Sbjct: 136 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKK 195
Query: 120 CLQMGMNRKAIREDGMP 136
CL+MGM ++++ + P
Sbjct: 196 CLEMGMKMESVQSERKP 212
Score = 63.9 bits (154), Expect = 3e-10
Identities = 46/176 (26%), Positives = 78/176 (44%), Gaps = 12/176 (6%)
Query: 287 LCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLS--------SLTVYSK 338
+C A LLF + W + +P F L T L+ + W EL L SL+
Sbjct: 405 ICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILA 464
Query: 339 QIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFL 398
I L + + S + + + ME I +L + +L + EYA +KAI
Sbjct: 465 AIVNHLQNSIQEDKLSGDRIKQV----MEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLF 520
Query: 399 NQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKM 454
+ D GLTS SQ+E+ ++ QD+ + Y+ R +++ LP +R ++ +
Sbjct: 521 SPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNI 576
>gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens]
Length = 497
Score = 103 bits (258), Expect = 3e-22
Identities = 41/72 (56%), Positives = 56/72 (77%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C ICGD+++G+HYG+I+CEGCKGFF+RS Y C+R +NC + R RNRCQ+CRL K
Sbjct: 10 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 69
Query: 120 CLQMGMNRKAIR 131
CL +GM+R A++
Sbjct: 70 CLALGMSRDAVK 81
>gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens]
Length = 518
Score = 103 bits (258), Expect = 3e-22
Identities = 41/72 (56%), Positives = 56/72 (77%)
Query: 60 CLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLK 119
C ICGD+++G+HYG+I+CEGCKGFF+RS Y C+R +NC + R RNRCQ+CRL K
Sbjct: 31 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 90
Query: 120 CLQMGMNRKAIR 131
CL +GM+R A++
Sbjct: 91 CLALGMSRDAVK 102
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 103 bits (258), Expect = 3e-22
Identities = 54/144 (37%), Positives = 74/144 (51%), Gaps = 9/144 (6%)
Query: 7 PPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRA---------EQ 57
P S G S EPP AL P P C E + G + ++ +
Sbjct: 17 PASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPK 76
Query: 58 RTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRL 117
R CL+CGD A+G HYG+ SCE CK FFKR+I Y C C +++++R CQ CR
Sbjct: 77 RLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRF 136
Query: 118 LKCLQMGMNRKAIREDGMPGGRNK 141
KCL++GM ++ +R D + GGR K
Sbjct: 137 TKCLRVGMLKEGVRLDRVRGGRQK 160
Score = 63.2 bits (152), Expect = 5e-10
Identities = 53/178 (29%), Positives = 84/178 (47%), Gaps = 14/178 (7%)
Query: 285 ALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGEL 344
A LC L D + I+W K +P F LS+ D +L S W E+++L + S + EL
Sbjct: 226 ATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVL-GVAQRSLPLQDEL 284
Query: 345 ADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRG 404
A A+ DEE R + G E+ L+ L + L++ EEY +KA+ N D
Sbjct: 285 A--FAEDLVLDEEGARAAGLG-ELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVH 341
Query: 405 LTSASQLEQLNKRYWYICQDFTEYKYTH-------QPNRFPDLMMCLPEIRYIAGKMV 455
+ A +EQL + + + EY+ + R L++ LP +R AGK++
Sbjct: 342 IEDAEAVEQLREA---LHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVL 396
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,502,258
Number of Sequences: 37866
Number of extensions: 1093957
Number of successful extensions: 8566
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 155
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 7893
Number of HSP's gapped (non-prelim): 526
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.