Search of human proteins with 52426735

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
         (3957 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                       7792   0.0  
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                       2928   0.0  
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                      2867   0.0  
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                       2129   0.0  
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                      1690   0.0  
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                       1680   0.0  
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                       1678   0.0  
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                       1678   0.0  
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                       1678   0.0  
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]                        838   0.0  
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   327   1e-88
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   314   1e-84
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   308   7e-83
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   307   2e-82
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   305   4e-82
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   296   2e-79
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  293   2e-78
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   249   3e-65
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   237   2e-61
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    237   2e-61
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   233   3e-60
gi|34304381 inversin isoform a [Homo sapiens]                         209   6e-53
gi|34304379 inversin isoform b [Homo sapiens]                         209   6e-53
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform...   208   1e-52
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   184   2e-45
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    180   2e-44
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    179   4e-44
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            173   3e-42
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   172   6e-42
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   172   6e-42

>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 7792 bits (20217), Expect = 0.0
 Identities = 3957/3957 (100%), Positives = 3957/3957 (100%)

Query: 1    MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTC 60
            MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTC
Sbjct: 1    MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTC 60

Query: 61   NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
            NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG
Sbjct: 61   NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120

Query: 121  ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
            ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA
Sbjct: 121  ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180

Query: 181  ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
            ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA
Sbjct: 181  ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240

Query: 241  AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300
            AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL
Sbjct: 241  AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300

Query: 301  TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360
            TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD
Sbjct: 301  TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360

Query: 361  VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420
            VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY
Sbjct: 361  VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 421  GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
            GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV
Sbjct: 421  GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480

Query: 481  RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540
            RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE
Sbjct: 481  RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540

Query: 541  GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
            GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL
Sbjct: 541  GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600

Query: 601  HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
            HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK
Sbjct: 601  HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660

Query: 661  QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
            QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD
Sbjct: 661  QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720

Query: 721  QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
            QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL
Sbjct: 721  QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780

Query: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840
            LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT
Sbjct: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840

Query: 841  EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900
            EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR
Sbjct: 841  EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900

Query: 901  SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALS 960
            SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALS
Sbjct: 901  SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALS 960

Query: 961  SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM 1020
            SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM
Sbjct: 961  SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM 1020

Query: 1021 VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE 1080
            VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE
Sbjct: 1021 VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE 1080

Query: 1081 IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC 1140
            IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC
Sbjct: 1081 IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC 1140

Query: 1141 RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP 1200
            RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP
Sbjct: 1141 RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP 1200

Query: 1201 MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRL 1260
            MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRL
Sbjct: 1201 MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRL 1260

Query: 1261 LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE 1320
            LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE
Sbjct: 1261 LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE 1320

Query: 1321 IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKP 1380
            IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKP
Sbjct: 1321 IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKP 1380

Query: 1381 IYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL 1440
            IYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL
Sbjct: 1381 IYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL 1440

Query: 1441 VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLAS 1500
            VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLAS
Sbjct: 1441 VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLAS 1500

Query: 1501 PDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLE 1560
            PDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLE
Sbjct: 1501 PDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLE 1560

Query: 1561 KVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVR 1620
            KVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVR
Sbjct: 1561 KVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVR 1620

Query: 1621 IDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGK 1680
            IDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGK
Sbjct: 1621 IDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGK 1680

Query: 1681 DIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGED 1740
            DIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGED
Sbjct: 1681 DIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGED 1740

Query: 1741 PGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKK 1800
            PGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKK
Sbjct: 1741 PGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKK 1800

Query: 1801 TTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPS 1860
            TTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPS
Sbjct: 1801 TTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPS 1860

Query: 1861 AKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSG 1920
            AKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSG
Sbjct: 1861 AKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSG 1920

Query: 1921 RTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSK 1980
            RTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSK
Sbjct: 1921 RTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSK 1980

Query: 1981 TERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQR 2040
            TERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQR
Sbjct: 1981 TERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQR 2040

Query: 2041 EAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP 2100
            EAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP
Sbjct: 2041 EAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP 2100

Query: 2101 EEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETE 2160
            EEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETE
Sbjct: 2101 EEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETE 2160

Query: 2161 KAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLME 2220
            KAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLME
Sbjct: 2161 KAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLME 2220

Query: 2221 GTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHP 2280
            GTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHP
Sbjct: 2221 GTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHP 2280

Query: 2281 TTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETP 2340
            TTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETP
Sbjct: 2281 TTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETP 2340

Query: 2341 TGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQ 2400
            TGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQ
Sbjct: 2341 TGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQ 2400

Query: 2401 GVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPL 2460
            GVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPL
Sbjct: 2401 GVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPL 2460

Query: 2461 KESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDD 2520
            KESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDD
Sbjct: 2461 KESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDD 2520

Query: 2521 SLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKK 2580
            SLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKK
Sbjct: 2521 SLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKK 2580

Query: 2581 RFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHT 2640
            RFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHT
Sbjct: 2581 RFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHT 2640

Query: 2641 GSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMD 2700
            GSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMD
Sbjct: 2641 GSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMD 2700

Query: 2701 SNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYD 2760
            SNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYD
Sbjct: 2701 SNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYD 2760

Query: 2761 KLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEK 2820
            KLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEK
Sbjct: 2761 KLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEK 2820

Query: 2821 DTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTD 2880
            DTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTD
Sbjct: 2821 DTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTD 2880

Query: 2881 ETFENLPKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSE 2940
            ETFENLPKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSE
Sbjct: 2881 ETFENLPKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSE 2940

Query: 2941 ESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQE 3000
            ESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQE
Sbjct: 2941 ESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQE 3000

Query: 3001 STLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVK 3060
            STLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVK
Sbjct: 3001 STLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVK 3060

Query: 3061 EEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMT 3120
            EEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMT
Sbjct: 3061 EEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMT 3120

Query: 3121 KRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEAD 3180
            KRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEAD
Sbjct: 3121 KRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEAD 3180

Query: 3181 LLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVK 3240
            LLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVK
Sbjct: 3181 LLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVK 3240

Query: 3241 QISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTES 3300
            QISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTES
Sbjct: 3241 QISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTES 3300

Query: 3301 KSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQ 3360
            KSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQ
Sbjct: 3301 KSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQ 3360

Query: 3361 LSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRER 3420
            LSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRER
Sbjct: 3361 LSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRER 3420

Query: 3421 AEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEE 3480
            AEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEE
Sbjct: 3421 AEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEE 3480

Query: 3481 ISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWD 3540
            ISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWD
Sbjct: 3481 ISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWD 3540

Query: 3541 ESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQ 3600
            ESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQ
Sbjct: 3541 ESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQ 3600

Query: 3601 IRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERI 3660
            IRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERI
Sbjct: 3601 IRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERI 3660

Query: 3661 SHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVG 3720
            SHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVG
Sbjct: 3661 SHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVG 3720

Query: 3721 YSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTE 3780
            YSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTE
Sbjct: 3721 YSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTE 3780

Query: 3781 TSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESS 3840
            TSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESS
Sbjct: 3781 TSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESS 3840

Query: 3841 PRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVT 3900
            PRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVT
Sbjct: 3841 PRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVT 3900

Query: 3901 RKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE 3957
            RKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Sbjct: 3901 RKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE 3957


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 2928 bits (7591), Expect = 0.0
 Identities = 1526/1761 (86%), Positives = 1575/1761 (89%), Gaps = 31/1761 (1%)

Query: 1    MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTC 60
            MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTC
Sbjct: 1    MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTC 60

Query: 61   NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
            NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG
Sbjct: 61   NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120

Query: 121  ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
            ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA
Sbjct: 121  ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180

Query: 181  ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
            ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA
Sbjct: 181  ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240

Query: 241  AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300
            AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL
Sbjct: 241  AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300

Query: 301  TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360
            TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD
Sbjct: 301  TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360

Query: 361  VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420
            VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY
Sbjct: 361  VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 421  GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
            GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV
Sbjct: 421  GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480

Query: 481  RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540
            RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE
Sbjct: 481  RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540

Query: 541  GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
            GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL
Sbjct: 541  GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600

Query: 601  HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
            HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK
Sbjct: 601  HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660

Query: 661  QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
            QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD
Sbjct: 661  QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720

Query: 721  QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
            QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL
Sbjct: 721  QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780

Query: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840
            LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT
Sbjct: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840

Query: 841  EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900
            EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR
Sbjct: 841  EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900

Query: 901  SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALS 960
            SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALS
Sbjct: 901  SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALS 960

Query: 961  SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM 1020
            SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM
Sbjct: 961  SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM 1020

Query: 1021 VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE 1080
            VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE
Sbjct: 1021 VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE 1080

Query: 1081 IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC 1140
            IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC
Sbjct: 1081 IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC 1140

Query: 1141 RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP 1200
            RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP
Sbjct: 1141 RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP 1200

Query: 1201 MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRL 1260
            MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRL
Sbjct: 1201 MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRL 1260

Query: 1261 LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE 1320
            LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE
Sbjct: 1261 LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE 1320

Query: 1321 IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKP 1380
            IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKP
Sbjct: 1321 IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKP 1380

Query: 1381 IYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL 1440
            IYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL
Sbjct: 1381 IYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL 1440

Query: 1441 VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLAS 1500
            VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKN + E        +++ + +   + 
Sbjct: 1441 VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLG-FSW 1499

Query: 1501 PDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPG----------EPFE 1550
             +L  E+   ++ + ++       + D++ ++    L +  +                 +
Sbjct: 1500 TELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMD 1559

Query: 1551 IVERVKEDLEKVNEILRSGTCTRDESSVQSSRSER-GLVEEEWVIVSDEEIEEARQKAPL 1609
            IV  ++ + E + E + S +    E ++    SE   +++EE      ++ EE       
Sbjct: 1560 IVHLMETNTEPLQERI-SHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKES 1618

Query: 1610 EITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEAL 1669
            E  ++P +    D  +     +D    V     D +     P+   + VQ     K + L
Sbjct: 1619 ETCDHPPIVSEEDISVGYSTFQDG---VPKTEGDSSATALFPQTHKEQVQQDFSGKMQDL 1675

Query: 1670 AVGRSSEKEGK---DIPPDETQSTQK-QHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEK 1725
                S E + +     P  ET  TQK    PS   K P           +E    A  EK
Sbjct: 1676 PEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTP-----------EEVSTPAEEEK 1724

Query: 1726 AELKKGSSEESLGEDPGLAPE 1746
              L+  +S E  G      PE
Sbjct: 1725 LYLQTPTSSERGGSPIIQEPE 1745



 Score =  803 bits (2073), Expect = 0.0
 Identities = 418/509 (82%), Positives = 436/509 (85%), Gaps = 25/509 (4%)

Query: 3453 CRGGTSPTKESKEH----FFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESS 3508
            C G   P  +S +H    FF    N +  F ++ D   +   RL+        + + +S+
Sbjct: 1385 CFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLS-------FMKEPKST 1437

Query: 3509 SALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQER 3568
              L    I NL       ++   I+      D+  E  I+   ++N       PQDEQER
Sbjct: 1438 RGLVHQAICNL-------NITLPIYTKESESDQEQEEEIDMTSEKN-------PQDEQER 1483

Query: 3569 IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA 3628
            IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA
Sbjct: 1484 IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA 1543

Query: 3629 TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT 3688
            TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT
Sbjct: 1544 TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT 1603

Query: 3689 AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ 3748
            AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ
Sbjct: 1604 AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ 1663

Query: 3749 VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE 3808
            VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE
Sbjct: 1664 VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE 1723

Query: 3809 KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF 3868
            KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF
Sbjct: 1724 KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF 1783

Query: 3869 EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV 3928
            EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV
Sbjct: 1784 EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV 1843

Query: 3929 NIEEGDGYSKVIKRVVLKSDTEQSEDNNE 3957
            NIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Sbjct: 1844 NIEEGDGYSKVIKRVVLKSDTEQSEDNNE 1872


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 2867 bits (7431), Expect = 0.0
 Identities = 1499/1747 (85%), Positives = 1549/1747 (88%), Gaps = 43/1747 (2%)

Query: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
            +KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR
Sbjct: 6    QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65

Query: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
            GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV
Sbjct: 66   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
            KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK
Sbjct: 126  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185

Query: 207  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
            SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG
Sbjct: 186  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245

Query: 267  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
            ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL
Sbjct: 246  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305

Query: 327  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
            ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD
Sbjct: 306  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365

Query: 387  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
            KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI
Sbjct: 366  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425

Query: 447  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
            VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR
Sbjct: 426  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485

Query: 507  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
            LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP
Sbjct: 486  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545

Query: 567  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
            LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA
Sbjct: 546  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 627  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
            KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA
Sbjct: 606  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665

Query: 687  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
            NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF
Sbjct: 666  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725

Query: 747  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
            LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY
Sbjct: 726  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785

Query: 807  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
            ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED
Sbjct: 786  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845

Query: 867  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
            LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV
Sbjct: 846  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905

Query: 927  VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSG------------FLVSFMV 974
            VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSG            FLVSFMV
Sbjct: 906  VIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMV 965

Query: 975  DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG 1034
            DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG
Sbjct: 966  DARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG 1025

Query: 1035 PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL 1094
            PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL
Sbjct: 1026 PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL 1085

Query: 1095 VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV 1154
            VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV
Sbjct: 1086 VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVV 1145

Query: 1155 SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA 1214
            SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA
Sbjct: 1146 SRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKA 1205

Query: 1215 TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE 1274
            TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE
Sbjct: 1206 TFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWE 1265

Query: 1275 DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA 1334
            DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA
Sbjct: 1266 DITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFA 1325

Query: 1335 KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK 1394
            KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK
Sbjct: 1326 KSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTK 1385

Query: 1395 SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI 1454
            SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI
Sbjct: 1386 SGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPI 1445

Query: 1455 YTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDL 1514
            YTKESESDQEQEEEIDMTSEKN + E        +++ + +   +  +L  E+   ++ +
Sbjct: 1446 YTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLG-FSWTELARELDFTEEQI 1504

Query: 1515 IKMTAILTTDVSDKAGSIKVKELVKAAEEEPG----------EPFEIVERVKEDLEKVNE 1564
             ++       + D++ ++    L +  +                 +IV  ++ + E + E
Sbjct: 1505 HQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQE 1564

Query: 1565 ILRSGTCTRDESSVQSSRSER-GLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDK 1623
             + S +    E ++    SE   +++EE      ++ EE       E  ++P +    D 
Sbjct: 1565 RI-SHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDI 1623

Query: 1624 EIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGK--- 1680
             +     +D    V     D +     P+   + VQ     K + L    S E + +   
Sbjct: 1624 SVGYSTFQDG---VPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFV 1680

Query: 1681 DIPPDETQSTQK-QHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGE 1739
              P  ET  TQK    PS   K P           +E    A  EK  L+  +S E  G 
Sbjct: 1681 TTPGTETSETQKAMIVPSSPSKTP-----------EEVSTPAEEEKLYLQTPTSSERGGS 1729

Query: 1740 DPGLAPE 1746
                 PE
Sbjct: 1730 PIIQEPE 1736



 Score =  803 bits (2073), Expect = 0.0
 Identities = 418/509 (82%), Positives = 436/509 (85%), Gaps = 25/509 (4%)

Query: 3453 CRGGTSPTKESKEH----FFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESS 3508
            C G   P  +S +H    FF    N +  F ++ D   +   RL+        + + +S+
Sbjct: 1376 CFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLS-------FMKEPKST 1428

Query: 3509 SALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQER 3568
              L    I NL       ++   I+      D+  E  I+   ++N       PQDEQER
Sbjct: 1429 RGLVHQAICNL-------NITLPIYTKESESDQEQEEEIDMTSEKN-------PQDEQER 1474

Query: 3569 IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA 3628
            IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA
Sbjct: 1475 IEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHA 1534

Query: 3629 TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT 3688
            TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT
Sbjct: 1535 TDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT 1594

Query: 3689 AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ 3748
            AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ
Sbjct: 1595 AQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQ 1654

Query: 3749 VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE 3808
            VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE
Sbjct: 1655 VQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEE 1714

Query: 3809 KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF 3868
            KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF
Sbjct: 1715 KLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAF 1774

Query: 3869 EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV 3928
            EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV
Sbjct: 1775 EKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPV 1834

Query: 3929 NIEEGDGYSKVIKRVVLKSDTEQSEDNNE 3957
            NIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Sbjct: 1835 NIEEGDGYSKVIKRVVLKSDTEQSEDNNE 1863


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 2129 bits (5517), Expect = 0.0
 Identities = 1068/1489 (71%), Positives = 1243/1489 (83%), Gaps = 78/1489 (5%)

Query: 23   RKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 82
            R R KKSD+NAS+LRAARAG+L+K ++Y+K G+DIN CNQNGLNALHLA+KEGHV +V E
Sbjct: 33   RDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92

Query: 83   LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142
            LL R ++VD+ATKKGNTALHIASLAGQAEVVKVLV  GAN+NAQSQNGFTPLYMAAQENH
Sbjct: 93   LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152

Query: 143  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
            ++VVK+LL+NGA+QS ATEDGFTPLAVALQQGH+Q V++LLENDTKGKVRLPALHIAARK
Sbjct: 153  LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARK 212

Query: 203  DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
            DDTK+AALLLQND+NADV+SK        SGFTPLHIAAHYGN+NVATLLLNR AAVDFT
Sbjct: 213  DDTKAAALLLQNDNNADVESK--------SGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 263  ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
            ARN ITPLHVASKRGN NMVKLLLDRG +IDAKTRDGLTPLHC ARSGH+QVVE+LL+R 
Sbjct: 265  ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 323  APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382
            AP+L++TKNGLSPLHMA QGDH+ CV+ LLQH  PVDDVT DYLTALHVAAHCGHY+V K
Sbjct: 325  APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384

Query: 383  LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 442
            +LLDK+ANPNA+ALNGFTPLHIACKKNRIKVMELL+K+GASIQA+TESGLTPIHVAAFMG
Sbjct: 385  VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444

Query: 443  HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 502
            H+NIV  L+ +GASP+ TN+RGETALHMAAR+GQ EVVR L+++GA V+A+A+++QTPLH
Sbjct: 445  HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504

Query: 503  IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562
            I++RLGK +IVQ LLQ  A P+AATT+GYTPLH+SAREG  DVA+ LL+ GA+ S+ TKK
Sbjct: 505  ISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK 564

Query: 563  GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622
            GFTPLHVAAKYG L+VA LLLQ+ A+ D+AGK+GLTPLHVAAHYDNQKVALLLL++GASP
Sbjct: 565  GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624

Query: 623  HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
            HA AKNGYTPLHIAAKKNQM IA+TLL YGA+ N VT+QG+  +HLA+QEGH DMV+LLL
Sbjct: 625  HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684

Query: 683  DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
             + AN+++S KSGLT LHLAAQED+VNVA++L   GA  DA TK+GYTPL V CHYGN+K
Sbjct: 685  GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIK 744

Query: 743  MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
            +VNFLL+  A VNAKTKNGYTPLHQAAQQGHTHIINVLLQ+ A PN  T NGNTAL IA+
Sbjct: 745  IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804

Query: 803  RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSD--------------- 847
            RLGYISVVDTLK+VTEE T TTTT+TEKHK+NVPETM EVLD+SD               
Sbjct: 805  RLGYISVVDTLKIVTEE-TMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDG 863

Query: 848  ------EEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRS 901
                  EEG+D MTGD  +YL P+DLKELGDDSLP+        Y+ +SL G RS SLRS
Sbjct: 864  EYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRS 916

Query: 902  FSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALS 960
            FSSDRS+TL+ +SY RDS ++++ +V    Q  T  +E + +S R  SW  + LDNV L 
Sbjct: 917  FSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLV 976

Query: 961  SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM 1020
            SSPIHSGFLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA     
Sbjct: 977  SSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLAN---- 1032

Query: 1021 VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE 1080
                                         PPP+ EGE L SR++++GP G +FLGPVIVE
Sbjct: 1033 -----------------------------PPPMVEGEGLASRLVEMGPAGAQFLGPVIVE 1063

Query: 1081 IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC 1140
            IPHF ++RGKEREL+VLRSENG++WKEH  D   ++L E+LNGMDE LDSPE+L KKRIC
Sbjct: 1064 IPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRIC 1123

Query: 1141 RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP 1200
            RIIT+DFPQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVGLQAQP
Sbjct: 1124 RIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQP 1183

Query: 1201 MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA-PTLR 1259
            +  E+VKKILGNKATFSPIVT+EPRRRKFHKPITMTIPVP  S + + NG+ GD  P LR
Sbjct: 1184 VPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLR 1243

Query: 1260 LLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYR 1319
            LLCSITGGT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V  A+Q+YR
Sbjct: 1244 LLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYR 1303

Query: 1320 EIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGK 1379
            E+ICVPYMAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+EVLEGK
Sbjct: 1304 ELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGK 1363

Query: 1380 PIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRG 1439
            PIYVDC+GNL PLTK GQ  +F+F++FKENRLP  +K+RDT+QEPCGRLSF+KEPK+T+G
Sbjct: 1364 PIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKG 1423

Query: 1440 LVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLK 1488
            L   A+CNLNITLP + KE+ESDQ+ E       EK D  +S  +  L+
Sbjct: 1424 LPQTAVCNLNITLPAHKKETESDQDDE------IEKTDRRQSFASLALR 1466



 Score =  322 bits (824), Expect = 6e-87
 Identities = 542/2358 (22%), Positives = 902/2358 (38%), Gaps = 294/2358 (12%)

Query: 1440 LVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLA 1499
            ++ + +C  N   P   K  +    +++ I+ +SE+  E      +     L   V V A
Sbjct: 1961 ILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKA 2020

Query: 1500 SPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDL 1559
                    SE   +L K+   LT D+    GS  +  L    E+   +  E  +RV    
Sbjct: 2021 KA-----ASEKDYNLTKVIDYLTNDI----GSSSLTNLKYKFEDAKKDGEERQKRVL--- 2068

Query: 1560 EKVNEILRSGTCTRDESSVQSSRSERGLVE-------EEWVIVSDEEIEEARQ-KAPLEI 1611
             K    L+        +S+++S SE+ L +        + ++ S ++  +  Q K+PL  
Sbjct: 2069 -KPAIALQEHKLKMPPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHDQDKSPLSD 2127

Query: 1612 TEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAV 1671
            + +   E R +K        +STG      +     VP+P    +T       + E + V
Sbjct: 2128 SGF---ETRSEKTPSAPQSAESTGPKPLFHE-----VPIPPVITET-------RTEVVHV 2172

Query: 1672 GRSSEKEGKDIP---PDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAE- 1727
             RS +    D+P   P+E  S +          KP    +KEK K  +  ++AS+E+ + 
Sbjct: 2173 IRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ--MKASSEEDDH 2230

Query: 1728 ---LKKG---SSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQ 1781
               L KG     E  +     +     P  +  S  IEET   S+ D +KA Q   +  +
Sbjct: 2231 NRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETM--SVHDIMKAFQSGRDPSK 2288

Query: 1782 KGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTER 1841
            +       +     DV        H +A+ +            PK ER   +      + 
Sbjct: 2289 ELAGLFEHKSAVSPDV--------HKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA 2340

Query: 1842 HPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKT---EKHSPVSPSTKTERHSPVSSTKT 1898
             P      +T+KH         +  S    + K    EKH     S +  +      T  
Sbjct: 2341 EPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAE 2400

Query: 1899 ERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTE 1958
            E  P    S + +         R      +S   + K L +      + H    +  + E
Sbjct: 2401 ESLPSYLESSRVNTPVSQEEDSRPSSAQLISDD-SYKTLKLLSQHSIEYHDDELSELRGE 2459

Query: 1959 KH-----------LPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHK 2007
             +           L VS S   E     +    +E        RE +      +  SK  
Sbjct: 2460 SYRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIY 2519

Query: 2008 TGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQ--KTENQTIKRGQRLPVTGTAESK 2065
              + E+   K  + +   KV V    G + + + A   +     + RG+   +       
Sbjct: 2520 KDVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIY------ 2573

Query: 2066 RGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPE--EESHRESEVPKEKMADEQGDMD 2123
                        ED      K    K+ E  Q   +  E+ + E + P++K   + G   
Sbjct: 2574 ------------EDRVDRTVKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGK-- 2619

Query: 2124 LQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYM 2183
             + S    TS+   +V+  EL           ++E  KA+ H       P    FP    
Sbjct: 2620 -EYSSQSPTSSSPEKVLLTEL--------LASNDEWVKARQH------GPDGQGFPKAEE 2664

Query: 2184 KDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETS 2243
            K   LP+ S +   L   +E  K+   A    GS+ +       +  ++     +  + S
Sbjct: 2665 KAPSLPS-SPEKMVLSQQTEDSKSTVEAK---GSISQSKAPDGPQSGFQ----LKQSKLS 2716

Query: 2244 PESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETS 2303
               L F      +    ++E  K++  + I  +K   +   +             D    
Sbjct: 2717 SIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAIDLPDE 2776

Query: 2304 TESFQKEATLGSPKDTSPKRQD---DCTGSCSVAL------AKETPTGLTEEAACDEGQR 2354
            + S QK+  +   KD   +  +   + +GS +V        +K  P   +E+ A D    
Sbjct: 2777 SVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKAMPDSFSEQQAKDLACH 2836

Query: 2355 TFGSSAHKTQTDSEV----QESTATSDETKALPLPEASVKTDTGTE-SKPQGVIRSPQGL 2409
                 A +   D +V    + S AT+++++   L    V          P+      +  
Sbjct: 2837 ITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRENHIGHPESKSVDQKNE 2896

Query: 2410 ELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSL 2469
             +++  R+ ++L+   + SL+   + ++++         +   +   P  L + P R S 
Sbjct: 2897 FMSVTERERKLLT---NGSLSEIKEMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSRRS- 2952

Query: 2470 ESSPV---------EPKMKAGIFPSHFPLPAAVAKTEL---LTEVASVRSRLLRDPDGSA 2517
            ESS V         E +M +   P  F   +A  K EL   L++ +  +  +      S 
Sbjct: 2953 ESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMSKETVETQHFNSI 3012

Query: 2518 EDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVT--PKTTDVSTPKPAVIHECAEEDDSE 2575
            ED+ +  + + + S         P  EE     T  P + + S  K +   +  +    +
Sbjct: 3013 EDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKESPSSDVFDHSPID 3072

Query: 2576 NGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDV- 2634
              EK     + E  K +  + ++    Q  KQ   Y+KE +Q         +     +  
Sbjct: 3073 GLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQ---YEKEIQQGGVKKIISQECKTVQETR 3129

Query: 2635 ----------DEPKHTGSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPE 2684
                        P   GS ED++   V     S K   + E+ P   ++     S   P+
Sbjct: 3130 GTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPET-PSSEEVSYEFTSKT-PD 3187

Query: 2685 PVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLA 2744
             +I   P  P P    S  S EE Q +    KQ T +     +E P  ++  KDS     
Sbjct: 3188 SLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMP--NDVSKDSNQRPK 3245

Query: 2745 EDRHAV-------STEAEDRSYDKLNR-------DTDQPKICDGHGCEAMSPS------S 2784
             +R A          +A+    DK +        D  +  + D H    ++         
Sbjct: 3246 NNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQPP 3305

Query: 2785 SAAPVSSGLQSPTGDDVDEQPV-IYKESLALQGTHEKDTEGEELDVSRAESPQADCPSES 2843
            S  P  + +   + D+   QPV + K +  L+          E+D  + E P+A     S
Sbjct: 3306 SPVPPGADVSDSSDDESIYQPVPVKKYTFKLK----------EVDDEQKEKPKASAEKAS 3355

Query: 2844 FSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITTQTDR 2903
                      L S G   D +        + E+ +     +++ +   +  +  +  TD 
Sbjct: 3356 NQKE------LESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDA 3409

Query: 2904 FSMD-VPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSV 2962
              +D +   DL + D+     +T     +P Q+     E K            +   +S 
Sbjct: 3410 TEIDSLDGYDLQDEDD----GLTESDSKLPIQAM----EIKKDIWNTEGILKPADRSFSQ 3461

Query: 2963 TITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWEMQSDSVSSSFEPTMSAT 3022
            +    +E+            SK S+ E    K + +  +  + ++      S  P    +
Sbjct: 3462 SKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFS 3521

Query: 3023 TTVVGEQIS--KVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTP 3080
              V  E  +  K + TK  +D D WS  R DDE F+++ +E+E K FGL V+ +S  TTP
Sbjct: 3522 YKVDEEFATPFKTVATK-GLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTP 3580

Query: 3081 DTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESRE 3140
            DTTPARTPT+E TPTSE NPF F EGK+FEMTRSGAIDM+KR + +E   FFQIG E   
Sbjct: 3581 DTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIG-EHTS 3639

Query: 3141 ETLSEDVKEG---ATGADPLPL--ETSAE-SLALSESKETVDDEADLLPDDVSEEVEEIP 3194
            E  S D  EG      A P P   +T+ E +L  +    TV+    +     S E +E  
Sbjct: 3640 EGKSGDQGEGDKSMVTATPQPQSGDTTVETNLERNVETPTVEPNPSI---PTSGECQEGT 3696

Query: 3195 ASDAQLNSQMG------ISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSS 3248
            +S   L           +     TP K  +S  T  +     G+I         SC    
Sbjct: 3697 SSSGSLEKSAAATNTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLE 3756

Query: 3249 EPAVQVQLDFSTLTRSV----YSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKI 3304
               + +  + +     V      D   D+ +++     S I+     M N+  TE  +  
Sbjct: 3757 NETITMISNTANSQMGVRPHEKHDFQKDNFNNNNNLDSSTIQTDNI-MSNIVLTEHSA-- 3813

Query: 3305 PVRTMPTSTPAPPSAEYESSVSE-----DFLSSVDEENKADE---AKPKSKLPVKVPLQR 3356
            P  T     P   S+  ++ V +     D    + E+ K  E    + KSKLP+K     
Sbjct: 3814 PTCTTEKDNPVKVSSGKKTGVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKA---- 3869

Query: 3357 VEQQLSDLDTSVQKTVAP------QGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSY 3410
                     TS + T  P      +   M  ++   ++K+ + +S +D K++ PVK    
Sbjct: 3870 ---------TSPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHR 3920

Query: 3411 TETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPT---------- 3460
                   +  A + + + E+G  + K L S+LPVK RST  +    T+ T          
Sbjct: 3921 DNIIAVRKACATQKQGQPEKG--KAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTT 3978

Query: 3461 ----KESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSERE-QEIVSDDESSSALEVSV 3515
                K  K    ++ ++SIE+F+ IS E  KLVDRL++ E++ Q  +SD+E S++   S+
Sbjct: 3979 SCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSL 4038

Query: 3516 IENL---PPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEER 3572
             E      P  T  S  +   +  P+  +S     E+   E        PQ   ER + R
Sbjct: 4039 SETSRGGQPSVTTKSARDKKTEAAPLKSKS-----EKAGSEKRSSRRTGPQSPCERTDIR 4093

Query: 3573 LAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTN 3632
            +A +ADHLG SWTELAREL+F+ ++I+QIR+ENPNSL  QS  LLK W+ RDGK+AT   
Sbjct: 4094 MAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDA 4153

Query: 3633 LVECLTKINRMDIVHLME 3650
            L   LTKINR+DIV L+E
Sbjct: 4154 LTSVLTKINRIDIVTLLE 4171



 Score =  125 bits (313), Expect = 1e-27
 Identities = 411/2017 (20%), Positives = 720/2017 (35%), Gaps = 352/2017 (17%)

Query: 1499 ASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKED 1558
            +S ++L +V+EMK+DL++MTAIL TDV ++       EL K    +  EPF+IVE+VKED
Sbjct: 1897 SSQEILKDVAEMKEDLMRMTAILQTDVPEEKPF--QPELPKEGRIDDEEPFKIVEKVKED 1954

Query: 1559 LEKVNEILRSGTCTRDESSVQSSRSERG-LVEEEWVIVSDEEIEEARQKAPLEITEYPCV 1617
            L KV+EIL+   C  ++ S +S +S++G   E++W+  S EEI EARQ+A    ++ P +
Sbjct: 1955 LVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQA--AASQSPSL 2012

Query: 1618 EVRIDKEIKGKVEKD--STGLVNYLTDDL--NTCVPLPKEQLQTVQDKAGKKCEALAVGR 1673
              R+  + K   EKD   T +++YLT+D+  ++   L  +     +D   ++   L    
Sbjct: 2013 PERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLTNLKYKFEDAKKDGEERQKRVLKPAI 2072

Query: 1674 SSEKEGKDIPPDETQSTQKQHK------------PSLGIKKPVRRKLKEKQKQKEEGLQA 1721
            + ++    +PP   +++  + +              L       +  ++K    + G + 
Sbjct: 2073 ALQEHKLKMPPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHDQDKSPLSDSGFET 2132

Query: 1722 SAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQ 1781
             +EK       S ES G  P     P+P      P+I ET              R E   
Sbjct: 2133 RSEKTP-SAPQSAESTGPKPLFHEVPIP------PVITET--------------RTEVVH 2171

Query: 1782 KGRSKLPIRVKGKEDVPKKTTHRP-HPAASPSLKSERHAPGSPS--PKTERHSTLSSSAK 1838
              RS  P       DVP+     P  P  SP+       P + S   K +     +SS +
Sbjct: 2172 VIRSYDP----SAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQMKASSEE 2227

Query: 1839 TERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKT 1898
             + +  +S   + ++ + ++ + +   HSP      +E+            H  + + ++
Sbjct: 2228 DDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEET-----MSVHDIMKAFQS 2282

Query: 1899 ERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTE 1958
             R P    +G  + +  VSP    +     S    EK   + P              K E
Sbjct: 2283 GRDPSKELAGLFEHKSAVSPDVH-KSAAETSAQHAEKDNQMKP--------------KLE 2327

Query: 1959 KHLPVSPSGKTEKQPP---VSPTSKTERIEETMSVRELMKAFQSGQD--PSKHKTGLFEH 2013
            + + V      + +P    +  T K    E  +  ++L +   + +D  P KH     + 
Sbjct: 2328 RIIEVHIEKGNQAEPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKH-----DA 2382

Query: 2014 KSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSI 2073
                ++Q Q++ +    +E  P   +     T           PV+   +S    R SS 
Sbjct: 2383 FPCSEEQGQQEEEELTAEESLPSYLESSRVNT-----------PVSQEEDS----RPSSA 2427

Query: 2074 GVKKEDAAGGKEKVLSHKIPEPVQSVPE--EESHRESEVPKEKMADEQGDMDLQISPDRK 2131
             +  +D+    + +  H I      + E   ES+R +E  K  ++++   +D+  S   +
Sbjct: 2428 QLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAE--KMLLSEK---LDVSHSDTEE 2482

Query: 2132 TSTDFSEVIKQELEDNDKYQQFRLSEETEKAQL-------------------HLDQVLTS 2172
            + TD +     EL+ +DK  + +++   +K  L                   H D+V   
Sbjct: 2483 SVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKDVSENGVGKVSKDEHFDKVTVL 2542

Query: 2173 PF--NTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEES 2230
             +  N + P   M   F          LD   E L  E           E   ++S    
Sbjct: 2543 HYSGNVSSPKHAMWMRF------TEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFFR 2596

Query: 2231 YKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETT--TEIRSEKEHPTTKDITGG 2288
             K E L +  + SPE  +  PK  +E + ++  S+  E    TE+ +  +    K    G
Sbjct: 2597 DKTEKLNDELQ-SPEKKA-RPKNGKEYSSQSPTSSSPEKVLLTELLASNDE-WVKARQHG 2653

Query: 2289 SEERGATVTEDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETP-TGL---- 2343
             + +G    E+   S  S  ++  L    + S K   +  GS S + A + P +G     
Sbjct: 2654 PDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDS-KSTVEAKGSISQSKAPDGPQSGFQLKQ 2712

Query: 2344 -------------TEEAACDEGQRTFGSSAHKTQTDSEVQEST-------ATSDETKALP 2383
                         T   + D  Q    S         ++QES        A   + KA+ 
Sbjct: 2713 SKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAID 2772

Query: 2384 LPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVL 2443
            LP+ SV               S Q   + L ++D    S    + + V+   S       
Sbjct: 2773 LPDESV---------------SVQKDFMVLKTKDEHAQS----NEIVVNDSGSDNVKKQR 2813

Query: 2444 EDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKT--ELLTE 2501
             + SS   PDS      K+  C  + + +   P  K  +F +     A   K+  E L+ 
Sbjct: 2814 TEMSSKAMPDSFSEQQAKDLACHITSDLATRGPWDKK-VFRTWESSGATNNKSQKEKLSH 2872

Query: 2502 VA--SVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVST 2559
            V    VR   +  P+  + D   E  S+ E   K   +      +E++         V +
Sbjct: 2873 VLVHDVRENHIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMT---------VKS 2923

Query: 2560 PKPAVIHE--CAEEDDSENGEKKRFTPEEEMFKMV-TKIKMFDELEQEAKQKRDYKKE-- 2614
            P   V++     +E D   G   + +   E   +    +++ DE    +    D   E  
Sbjct: 2924 PSKKVLYREYVVKEGDHPGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFCEQS 2983

Query: 2615 --PKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVSSSSESEPELAQ 2672
              PK E S   S   +  S +  E +H  S EDE     +  SE  KVS           
Sbjct: 2984 AFPKHELSQKLS--QSSMSKETVETQHFNSIEDEK----VTYSEISKVSKHQSYVGLCPP 3037

Query: 2673 LKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSP----------------EEVQFQPV-VS 2715
            L++   S       +   P    PSS   + SP                +E++  PV VS
Sbjct: 3038 LEETETSPTKSPDSLEFSPGKESPSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVS 3097

Query: 2716 KQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRS----YDKLNRDT-DQPK 2770
                 K  E   ++ G  +        + E R    T  + +           DT +Q  
Sbjct: 3098 FVQVGKQYEKEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVS 3157

Query: 2771 ICDGHGCEAMSPSS-SAAPVSSGLQSPTGDD-----------VDEQPVIYKESLALQGTH 2818
              D  G   ++P + S+  VS    S T D            + E     +E    + T 
Sbjct: 3158 FLDSSGKSPLTPETPSSEEVSYEFTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTS 3217

Query: 2819 EKDTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTK 2878
             K T  EE  V R         S     ++ + +        LD D             +
Sbjct: 3218 LKQTTVEETAVEREMPNDVSKDSNQRPKNNRVAYIEFPPPPPLDAD-----------QIE 3266

Query: 2879 TDETFENLP-KDCPSQDSSITTQTDRFSMDVP---------------VSDLAENDEIYDP 2922
            +D+    LP K+    + ++  + D++ +  P               VSD ++++ IY P
Sbjct: 3267 SDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQPPSPVPPGADVSDSSDDESIYQP 3326

Query: 2923 QITSPY--------ENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVA 2974
                 Y        +    +   S+E++  Q +     S   +E + + + SP  ++   
Sbjct: 3327 VPVKKYTFKLKEVDDEQKEKPKASAEKASNQKELESNGSGKDNE-FGLGLDSPQNEIAQN 3385

Query: 2975 SSSSGTVLSKESNFEGQDIKMESQQESTLWEMQSDSVSSSFEP----TMSATTTVVGEQI 3030
             ++              D  +     +T  E   D+ ++  +      +      + E  
Sbjct: 3386 GNN--------------DQSITECSIATTAEFSHDTDATEIDSLDGYDLQDEDDGLTESD 3431

Query: 3031 SKVIITKTDVDSDSWSE---IREDDEAF---EARVKEEEQKIFGLMVDRQSQGTTPDTTP 3084
            SK+ I   ++  D W+    ++  D +F   +  V EEE K+          G   D  P
Sbjct: 3432 SKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKV----------GPDEDKPP 3481

Query: 3085 ARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLS 3144
            +++ + E TP         + G  F        D   RS   +++  +++ +E    T  
Sbjct: 3482 SKSSSSEKTPDKTDQ----KSGAQFFTLEGRHPD---RSVFPDTYFSYKVDEEF--ATPF 3532

Query: 3145 EDVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASDAQLNSQM 3204
            + V       DP       + +  S+S+E       L  +D S      PA+        
Sbjct: 3533 KTVATKGLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRS------PATTPD----- 3581

Query: 3205 GISASTETPTKEAVSVGTKDLPTVQTGDIPPLSG-----VKQISCPDSSEPAVQVQLDFS 3259
              +    TPT E+        PT +    P   G      +  +   S    V+ +L F 
Sbjct: 3582 --TTPARTPTDEST-------PTSEPNPFPFHEGKMFEMTRSGAIDMSKRDFVEERLQFF 3632

Query: 3260 TLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKIPVRTMPTSTP---AP 3316
             +       +  D      E  KS++     P       E+  +  V T PT  P    P
Sbjct: 3633 QIGEHTSEGKSGD----QGEGDKSMVTATPQPQSGDTTVETNLERNVET-PTVEPNPSIP 3687

Query: 3317 PSAE-YESSVSEDFLSSVDEENKADEAKPKSKLPVKV 3352
             S E  E + S   L          +  PK + P+K+
Sbjct: 3688 TSGECQEGTSSSGSLEKSAAATNTSKVDPKLRTPIKM 3724


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 1690 bits (4377), Expect = 0.0
 Identities = 877/1519 (57%), Positives = 1112/1519 (73%), Gaps = 73/1519 (4%)

Query: 4    EDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQN 63
            ++  +K +S  K    S+ RK  KK+D+  SFLRAAR+GNLDK +++L+ G+DINTCNQN
Sbjct: 20   QEQKEKEESNRKRRNRSRDRK--KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQN 77

Query: 64   GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
            GLN LHLA+KEGHV +V ELL +   +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+
Sbjct: 78   GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137

Query: 124  NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
            NAQSQ GFTPLYMAAQENH++VVK+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+
Sbjct: 138  NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 197

Query: 184  ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
               TKGKVRLPALHIAAR DDT++AA+LLQND N DV SK        +GFTPLHIAAHY
Sbjct: 198  NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK--------TGFTPLHIAAHY 249

Query: 244  GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
             N+NVA LLLNRGA+V+FT +NGITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPL
Sbjct: 250  ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309

Query: 304  HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363
            HCAAR+GH ++ E+LL+ GAP+ A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TL
Sbjct: 310  HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 369

Query: 364  DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
            D+LT LHVAAHCGH+RV K+LLDK A PN+RALNGFTPLHIACKKN ++VMELL+K GAS
Sbjct: 370  DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429

Query: 424  IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
            I A+TESGLTP+HVA+FMGHL IV  LLQ GASP+V+N++ ET LHMAARAG  EV + L
Sbjct: 430  IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489

Query: 484  LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
            L+N A V+A+A+++QTPLH A+R+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V
Sbjct: 490  LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549

Query: 544  DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
            +    LLE  A+ +  TKKGFTPLHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA
Sbjct: 550  ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609

Query: 604  AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663
             H++N  +  LLL +G SPH+ A NGYTPLHIAAK+NQ+++A +LL YG   N  + QGV
Sbjct: 610  VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV 669

Query: 664  TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
            TPLHLA+QEGH +MV LLL K AN ++  KSGLT LHL AQE  V VAD+L KHG   DA
Sbjct: 670  TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729

Query: 724  HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
             T++GYTPL VA HYGN+K+V FLL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++
Sbjct: 730  TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789

Query: 784  GAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVL 843
            GA PN  +++G T LAIAKRLGYISV D LKVVT+E  T+   +++KH+++ PET+ E+L
Sbjct: 790  GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEIL 847

Query: 844  DVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFS 903
            DVS++EG   +T  G E +  +  +    D     + LD                   F 
Sbjct: 848  DVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLD-------------------FV 888

Query: 904  SDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSS 962
                  +   +  R    M ++VVI S +    +KE + +S    S  TE  DN++  +S
Sbjct: 889  PKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVAS 948

Query: 963  PIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVE 1022
            P+H+GFLVSFMVDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E
Sbjct: 949  PVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAE 1008

Query: 1023 GEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIP 1082
             EGLASR+I +GP+GAQ                                 FL PVIVEIP
Sbjct: 1009 EEGLASRIIALGPTGAQ---------------------------------FLSPVIVEIP 1035

Query: 1083 HFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRI 1142
            HFA+    +RELVVLRSENG  WKEH   Y E  L++ILNGMDE L S E+LEKKR+CRI
Sbjct: 1036 HFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI 1095

Query: 1143 ITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMH 1202
            IT DFP YF ++SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ 
Sbjct: 1096 ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVP 1155

Query: 1203 SELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLC 1262
             ELV K+LGN+ATFSPIVT+EPRRRKFH+PI + IP+P + +D   +   GD  +LRLLC
Sbjct: 1156 DELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLC 1215

Query: 1263 SITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREII 1322
            S+ GGT  AQWEDITGTT L + NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+ 
Sbjct: 1216 SVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT 1275

Query: 1323 CVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIY 1382
             VPYMAKFV+FAK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++
Sbjct: 1276 AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLF 1335

Query: 1383 VDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVH 1442
             +  GNLVP+ K+ Q   F F +F+ENRL + VKVRD+++EP G LSF+++        H
Sbjct: 1336 AELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH 1395

Query: 1443 QAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETES-------TETSVLKSHLVNEV 1495
              +C+LNIT+P   K S ++  +     +    +  +ES       TE + +K  +++E 
Sbjct: 1396 -ILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEH 1454

Query: 1496 PVLASPDLLSEVSEMKQDL 1514
              L+  +L  E+    +D+
Sbjct: 1455 LGLSWAELARELQFSVEDI 1473



 Score = 95.5 bits (236), Expect = 9e-19
 Identities = 49/121 (40%), Positives = 79/121 (65%), Gaps = 1/121 (0%)

Query: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626
            E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL  W+ R+G+
Sbjct: 1442 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1501

Query: 3627 HATDTNLVECLTKINRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE 3685
            +A   NL   L  I+R +IV+++E +  +    +    + + + +++     G+S LQ+E
Sbjct: 1502 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1561

Query: 3686 L 3686
            L
Sbjct: 1562 L 1562



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 19/48 (39%), Positives = 30/48 (62%)

Query: 3870 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 3917
            +G++   IP E VTEE++ DE G+ V KK+ RK++R+   S     +E
Sbjct: 1839 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1886


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 1680 bits (4351), Expect = 0.0
 Identities = 899/1698 (52%), Positives = 1171/1698 (68%), Gaps = 88/1698 (5%)

Query: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
            +++D+  SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
               +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
            K+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 207  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
            +AA+LLQND N DV SK        +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188  TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 267  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
            ITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+ 
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 327  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
            A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 387  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
            K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 447  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
            V  LLQ GASP+V+N++ ET LHMAARAG  EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 507  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
            +G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+    LLE  A+ +  TKKGFTP
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 567  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
            LHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA H++N  +  LLL +G SPH+ A
Sbjct: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 627  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
             NGYTPLHIAAK+NQ+++A +LL YG   N  + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 687  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
            N ++  KSGLT LHL AQE  V VAD+L KHG   DA T++GYTPL VA HYGN+K+V F
Sbjct: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 747  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
            LL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN  +++G T LAIAKRLGY
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 807  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
            ISV D LKVVT+E  T+   +++KH+++ PET+ E+LDVS++EG++ ++           
Sbjct: 780  ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831

Query: 867  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
                                 R S +      L  F       +   +  R    M ++V
Sbjct: 832  ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870

Query: 927  VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985
            VI S +    +KE + +S    S  TE  DN++  +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 871  VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930

Query: 986  HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045
            HNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E EGLASR+I +GP+GAQ      
Sbjct: 931  HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984

Query: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105
                                       FL PVIVEIPHFA+    +RELVVLRSENG  W
Sbjct: 985  ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017

Query: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165
            KEH   Y E  L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077

Query: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225
            PEGG L S +VP VQA FPE A+TKR+++ LQAQP+  ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137

Query: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285
            RRKFH+PI + IP+P + +D   +   GD  +LRLLCS+ GGT  AQWEDITGTT L + 
Sbjct: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197

Query: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345
            NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+  VPYMAKFV+FAK +DP E RLR
Sbjct: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257

Query: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405
            C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++ +  GNLVP+ K+ Q   F F +
Sbjct: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317

Query: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465
            F+ENRL + VKVRD+++EP G LSF+++        H  +C+LNIT+P   K S ++  +
Sbjct: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376

Query: 1466 EEEIDMTSEKNDETES-------TETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMT 1518
                 +    +  +ES       TE + +K  +++E   L+  +L  E+    +D+ ++ 
Sbjct: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIR 1436

Query: 1519 AILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTRDESSV 1578
                  + +++ ++    +++  +    E      +  +  E VN +  SG  +R     
Sbjct: 1437 VENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSR----- 1491

Query: 1579 QSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTG-LV 1637
             + + +R   + ++ +   +      Q+    IT  P V    ++      + D+ G +V
Sbjct: 1492 -NLKPDRRHTDRDYSLSPSQ--MNGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIV 1548

Query: 1638 NYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPS 1697
            +YL D           Q            E L  G S E E   +   E   T++    S
Sbjct: 1549 SYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAES 1608

Query: 1698 LGIKKPVRRKLKEKQKQK 1715
                +  R++ +E+Q Q+
Sbjct: 1609 SQADRDRRQQGQEEQVQE 1626



 Score =  348 bits (892), Expect = 8e-95
 Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)

Query: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH A++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
           LL +   L   TK G + LH+AA     E V+ L+ + A V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437
             V K LL+  AN N    +GFTPL +A ++    V+  L+ YG       +  L  +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179

Query: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
           AA         +LLQN  +PDV +  G T LH+AA    + V + LL  GA V+   +  
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
            TPLHIASR G   +V+LLL   A  +  T +  TPLH +AR G V ++ +LL+ GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
             TK G +P+H+AA+   LD  +LLLQ  A  D    + LTPLHVAAH  + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
           KGA P++ A NG+TPLHIA KKN +++   LL  GA  + VT+ G+TPLH+AS  GH  +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
           V  LL +GA+ ++S     T LH+AA+     VA  L ++ A  +A  K   TPL  A  
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
            G+  MV  LL+  AN N  T  G+TPLH AA++GH   +  LL+  A     T  G T 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 798 LAIAKRLGYISVVDTL 813
           L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555



 Score =  201 bits (512), Expect = 9e-51
 Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)

Query: 15  KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74
           K+   ++ +   K  D       AAR G+ + V   L+   + N     G   LH+AA+E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 75  GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
           GHV  V  LL + +S    TKKG T LH+A+  G+  V ++L++  A+ NA  +NG TPL
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192
           ++A   N++D+VK LL  G +  +   +G+TPL +A +Q   +    LL+          
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
             +  LH+AA++   +  ALLL    N ++ +K        SG TPLH+ A  G+V VA 
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685

Query: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
           +L+  G  VD T R G TPLHVAS  GN  +VK LL     ++AKT+ G +PLH AA+ G
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745

Query: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339
           H  +V LLL+ GA     + +G +PL +A
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 93.6 bits (231), Expect = 4e-18
 Identities = 96/370 (25%), Positives = 164/370 (44%), Gaps = 75/370 (20%)

Query: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626
            E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL  W+ R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460

Query: 3627 HATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL 3686
            +A   NL   L  I+R +IV+++E +      R S +     +    D+S   S +    
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGS-----GRQSRNLKPDRRHTDRDYSLSPSQMN--- 1512

Query: 3687 CTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHK 3746
                H++ + +          H P VS+          QD +   + D S  +      +
Sbjct: 1513 ---GHQRGQARIT--------HSPTVSQVT-----ERSQDRLQDWDADGSIVSYLQDAAQ 1556

Query: 3747 EQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTP 3804
               Q++ +         S++    E     PG  + E +K ++  S  + T  PE  S+ 
Sbjct: 1557 GSWQEEVTQGPHSFQGTSTMTEGLE-----PG-GSQEYEKVLVSVSEHTWTEQPEAESSQ 1610

Query: 3805 AEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDE 3864
            A+ ++         ++G    +QE             + T   +V+  + Q    E++ E
Sbjct: 1611 ADRDR--------RQQGQEEQVQE------------AKNTFTQVVQGNEFQNIPGEQVTE 1650

Query: 3865 DAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSE---GTEKEEIMVQ 3921
                           E  T+E+     G+ V KK+ RK++R+   S      E EE+ V+
Sbjct: 1651 ---------------EQFTDEQ-----GNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVE 1690

Query: 3922 GMPQEPVNIE 3931
            G  ++P  +E
Sbjct: 1691 GPLEDPSELE 1700


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 1678 bits (4346), Expect = 0.0
 Identities = 866/1496 (57%), Positives = 1098/1496 (73%), Gaps = 79/1496 (5%)

Query: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
            +++D+  SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
               +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
            K+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 207  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
            +AA+LLQND N DV SK        +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188  TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 267  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
            ITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+ 
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 327  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
            A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 387  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
            K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 447  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
            V  LLQ GASP+V+N++ ET LHMAARAG  EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 507  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
            +G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+    LLE  A+ +  TKKGFTP
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 567  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
            LHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA H++N  +  LLL +G SPH+ A
Sbjct: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 627  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
             NGYTPLHIAAK+NQ+++A +LL YG   N  + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 687  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
            N ++  KSGLT LHL AQE  V VAD+L KHG   DA T++GYTPL VA HYGN+K+V F
Sbjct: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 747  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
            LL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN  +++G T LAIAKRLGY
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 807  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
            ISV D LKVVT+E  T+   +++KH+++ PET+ E+LDVS++EG++ ++           
Sbjct: 780  ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831

Query: 867  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
                                 R S +      L  F       +   +  R    M ++V
Sbjct: 832  ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870

Query: 927  VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985
            VI S +    +KE + +S    S  TE  DN++  +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 871  VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930

Query: 986  HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045
            HNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E EGLASR+I +GP+GAQ      
Sbjct: 931  HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984

Query: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105
                                       FL PVIVEIPHFA+    +RELVVLRSENG  W
Sbjct: 985  ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017

Query: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165
            KEH   Y E  L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077

Query: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225
            PEGG L S +VP VQA FPE A+TKR+++ LQAQP+  ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137

Query: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285
            RRKFH+PI + IP+P + +D   +   GD  +LRLLCS+ GGT  AQWEDITGTT L + 
Sbjct: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197

Query: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345
            NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+  VPYMAKFV+FAK +DP E RLR
Sbjct: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257

Query: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405
            C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++ +  GNLVP+ K+ Q   F F +
Sbjct: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317

Query: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465
            F+ENRL + VKVRD+++EP G LSF+++        H  +C+LNIT+P   K S ++  +
Sbjct: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376

Query: 1466 EEEIDMTSEKNDETES-------TETSVLKSHLVNEVPVLASPDLLSEVSEMKQDL 1514
                 +    +  +ES       TE + +K  +++E   L+  +L  E+    +D+
Sbjct: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDI 1432



 Score =  348 bits (892), Expect = 8e-95
 Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)

Query: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH A++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
           LL +   L   TK G + LH+AA     E V+ L+ + A V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437
             V K LL+  AN N    +GFTPL +A ++    V+  L+ YG       +  L  +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179

Query: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
           AA         +LLQN  +PDV +  G T LH+AA    + V + LL  GA V+   +  
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
            TPLHIASR G   +V+LLL   A  +  T +  TPLH +AR G V ++ +LL+ GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
             TK G +P+H+AA+   LD  +LLLQ  A  D    + LTPLHVAAH  + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
           KGA P++ A NG+TPLHIA KKN +++   LL  GA  + VT+ G+TPLH+AS  GH  +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
           V  LL +GA+ ++S     T LH+AA+     VA  L ++ A  +A  K   TPL  A  
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
            G+  MV  LL+  AN N  T  G+TPLH AA++GH   +  LL+  A     T  G T 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 798 LAIAKRLGYISVVDTL 813
           L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555



 Score =  201 bits (512), Expect = 9e-51
 Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)

Query: 15  KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74
           K+   ++ +   K  D       AAR G+ + V   L+   + N     G   LH+AA+E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 75  GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
           GHV  V  LL + +S    TKKG T LH+A+  G+  V ++L++  A+ NA  +NG TPL
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192
           ++A   N++D+VK LL  G +  +   +G+TPL +A +Q   +    LL+          
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
             +  LH+AA++   +  ALLL    N ++ +K        SG TPLH+ A  G+V VA 
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685

Query: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
           +L+  G  VD T R G TPLHVAS  GN  +VK LL     ++AKT+ G +PLH AA+ G
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745

Query: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339
           H  +V LLL+ GA     + +G +PL +A
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 96.3 bits (238), Expect = 5e-19
 Identities = 112/463 (24%), Positives = 192/463 (41%), Gaps = 99/463 (21%)

Query: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626
            E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL  W+ R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460

Query: 3627 HATDTNLVECLTKINRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE 3685
            +A   NL   L  I+R +IV+++E +  +    +    + + + +++     G+S LQ+E
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520

Query: 3686 L-------CTAQHKQKEEQ------------AVSKESETCDH------------PPIVSE 3714
            L       C      + +Q              + E +T               P +V+ 
Sbjct: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580

Query: 3715 EDISVGYSTFQDGVP-----KTEGDSSATALFPQ------THKEQVQQDFSGKMQDLPEE 3763
            ED S+  S  +D        K EG  S     P+         + V  D +  + DL E+
Sbjct: 1581 EDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQ 1640

Query: 3764 SSLEYQQEYFV-------TTPGTETSETQKAMI-------VPSSPSKTPEEVSTPAEEEK 3809
               +  +E           T   + SE + +++          + S T  +V T   +++
Sbjct: 1641 EEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQV-TERSQDR 1699

Query: 3810 L-----------YLQTPTSSE-----RGGSPIIQEPEEPSEHREESSPRKTSLVIVESAD 3853
            L           YLQ             G    Q     +E  E    ++   V+V  ++
Sbjct: 1700 LQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSE 1759

Query: 3854 N----QPET-CERLDEDAAFEKGDDMPEIPPETVTE------------EEYIDE-----H 3891
            +    QPE    + D D   +  ++  +    T T+            E+  +E      
Sbjct: 1760 HTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQ 1819

Query: 3892 GHTVVKKVTRKIIRRYVSSE---GTEKEEIMVQGMPQEPVNIE 3931
            G+ V KK+ RK++R+   S      E EE+ V+G  ++P  +E
Sbjct: 1820 GNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELE 1862


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 1678 bits (4346), Expect = 0.0
 Identities = 866/1496 (57%), Positives = 1098/1496 (73%), Gaps = 79/1496 (5%)

Query: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
            +++D+  SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
               +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
            K+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 207  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
            +AA+LLQND N DV SK        +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188  TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 267  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
            ITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+ 
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 327  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
            A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 387  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
            K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 447  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
            V  LLQ GASP+V+N++ ET LHMAARAG  EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 507  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
            +G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+    LLE  A+ +  TKKGFTP
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 567  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
            LHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA H++N  +  LLL +G SPH+ A
Sbjct: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 627  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
             NGYTPLHIAAK+NQ+++A +LL YG   N  + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 687  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
            N ++  KSGLT LHL AQE  V VAD+L KHG   DA T++GYTPL VA HYGN+K+V F
Sbjct: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 747  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
            LL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN  +++G T LAIAKRLGY
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 807  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
            ISV D LKVVT+E  T+   +++KH+++ PET+ E+LDVS++EG++ ++           
Sbjct: 780  ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831

Query: 867  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
                                 R S +      L  F       +   +  R    M ++V
Sbjct: 832  ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870

Query: 927  VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985
            VI S +    +KE + +S    S  TE  DN++  +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 871  VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930

Query: 986  HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045
            HNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E EGLASR+I +GP+GAQ      
Sbjct: 931  HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984

Query: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105
                                       FL PVIVEIPHFA+    +RELVVLRSENG  W
Sbjct: 985  ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017

Query: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165
            KEH   Y E  L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077

Query: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225
            PEGG L S +VP VQA FPE A+TKR+++ LQAQP+  ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137

Query: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285
            RRKFH+PI + IP+P + +D   +   GD  +LRLLCS+ GGT  AQWEDITGTT L + 
Sbjct: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197

Query: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345
            NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+  VPYMAKFV+FAK +DP E RLR
Sbjct: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257

Query: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405
            C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++ +  GNLVP+ K+ Q   F F +
Sbjct: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317

Query: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465
            F+ENRL + VKVRD+++EP G LSF+++        H  +C+LNIT+P   K S ++  +
Sbjct: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376

Query: 1466 EEEIDMTSEKNDETES-------TETSVLKSHLVNEVPVLASPDLLSEVSEMKQDL 1514
                 +    +  +ES       TE + +K  +++E   L+  +L  E+    +D+
Sbjct: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDI 1432



 Score =  348 bits (892), Expect = 8e-95
 Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)

Query: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH A++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
           LL +   L   TK G + LH+AA     E V+ L+ + A V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437
             V K LL+  AN N    +GFTPL +A ++    V+  L+ YG       +  L  +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179

Query: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
           AA         +LLQN  +PDV +  G T LH+AA    + V + LL  GA V+   +  
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
            TPLHIASR G   +V+LLL   A  +  T +  TPLH +AR G V ++ +LL+ GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
             TK G +P+H+AA+   LD  +LLLQ  A  D    + LTPLHVAAH  + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
           KGA P++ A NG+TPLHIA KKN +++   LL  GA  + VT+ G+TPLH+AS  GH  +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
           V  LL +GA+ ++S     T LH+AA+     VA  L ++ A  +A  K   TPL  A  
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
            G+  MV  LL+  AN N  T  G+TPLH AA++GH   +  LL+  A     T  G T 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 798 LAIAKRLGYISVVDTL 813
           L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555



 Score =  201 bits (512), Expect = 9e-51
 Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)

Query: 15  KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74
           K+   ++ +   K  D       AAR G+ + V   L+   + N     G   LH+AA+E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 75  GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
           GHV  V  LL + +S    TKKG T LH+A+  G+  V ++L++  A+ NA  +NG TPL
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192
           ++A   N++D+VK LL  G +  +   +G+TPL +A +Q   +    LL+          
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
             +  LH+AA++   +  ALLL    N ++ +K        SG TPLH+ A  G+V VA 
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685

Query: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
           +L+  G  VD T R G TPLHVAS  GN  +VK LL     ++AKT+ G +PLH AA+ G
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745

Query: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339
           H  +V LLL+ GA     + +G +PL +A
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 116/478 (24%), Positives = 201/478 (42%), Gaps = 100/478 (20%)

Query: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626
            E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL  W+ R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460

Query: 3627 HATDTNLVECLTKINRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE 3685
            +A   NL   L  I+R +IV+++E +  +    +    + + + +++     G+S LQ+E
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520

Query: 3686 L-------CTAQHKQKEEQ------------AVSKESETCDH------------PPIVSE 3714
            L       C      + +Q              + E +T               P +V+ 
Sbjct: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580

Query: 3715 EDISVGYSTFQDGVP-----KTEGDSSATALFPQ------THKEQVQQDFSGKMQDLPEE 3763
            ED S+  S  +D        K EG  S     P+         + V  D +  + DL E+
Sbjct: 1581 EDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQ 1640

Query: 3764 SSLEYQQEYFV-------TTPGTETSETQKAMI-------VPSSPSKTPEEVSTPAEEEK 3809
               +  +E           T   + SE + +++          + S T  +V T   +++
Sbjct: 1641 EEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQV-TERSQDR 1699

Query: 3810 L-----------YLQTPTSSE-----RGGSPIIQEPEEPSEHREESSPRKTSLVIVESAD 3853
            L           YLQ             G    Q     +E  E    ++   V+V  ++
Sbjct: 1700 LQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSE 1759

Query: 3854 N----QPET-CERLDEDAAFEKGDDMPEIPPETVTE------------EEYIDE-----H 3891
            +    QPE    + D D   +  ++  +    T T+            E+  +E      
Sbjct: 1760 HTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQ 1819

Query: 3892 GHTVVKKVTRKIIRRYVSSE---GTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLK 3946
            G+ V KK+ RK++R+   S      E EE+ ++G   +P ++ EG   ++++KR  LK
Sbjct: 1820 GNIVTKKIIRKVVRQIDLSSADAAQEHEEVELRGSGLQP-DLIEGRKGAQIVKRASLK 1876


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 1678 bits (4346), Expect = 0.0
 Identities = 866/1496 (57%), Positives = 1098/1496 (73%), Gaps = 79/1496 (5%)

Query: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
            +++D+  SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
               +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
            K+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 207  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
            +AA+LLQND N DV SK        +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 188  TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 267  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
            ITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+ 
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 327  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
            A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 387  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
            K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 447  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
            V  LLQ GASP+V+N++ ET LHMAARAG  EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 507  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
            +G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+    LLE  A+ +  TKKGFTP
Sbjct: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 567  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
            LHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA H++N  +  LLL +G SPH+ A
Sbjct: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 627  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
             NGYTPLHIAAK+NQ+++A +LL YG   N  + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 687  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
            N ++  KSGLT LHL AQE  V VAD+L KHG   DA T++GYTPL VA HYGN+K+V F
Sbjct: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 747  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
            LL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN  +++G T LAIAKRLGY
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 807  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
            ISV D LKVVT+E  T+   +++KH+++ PET+ E+LDVS++EG++ ++           
Sbjct: 780  ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831

Query: 867  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
                                 R S +      L  F       +   +  R    M ++V
Sbjct: 832  ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870

Query: 927  VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985
            VI S +    +KE + +S    S  TE  DN++  +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 871  VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930

Query: 986  HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045
            HNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E EGLASR+I +GP+GAQ      
Sbjct: 931  HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984

Query: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105
                                       FL PVIVEIPHFA+    +RELVVLRSENG  W
Sbjct: 985  ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017

Query: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165
            KEH   Y E  L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077

Query: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225
            PEGG L S +VP VQA FPE A+TKR+++ LQAQP+  ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137

Query: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285
            RRKFH+PI + IP+P + +D   +   GD  +LRLLCS+ GGT  AQWEDITGTT L + 
Sbjct: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197

Query: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345
            NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+  VPYMAKFV+FAK +DP E RLR
Sbjct: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257

Query: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405
            C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++ +  GNLVP+ K+ Q   F F +
Sbjct: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317

Query: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465
            F+ENRL + VKVRD+++EP G LSF+++        H  +C+LNIT+P   K S ++  +
Sbjct: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376

Query: 1466 EEEIDMTSEKNDETES-------TETSVLKSHLVNEVPVLASPDLLSEVSEMKQDL 1514
                 +    +  +ES       TE + +K  +++E   L+  +L  E+    +D+
Sbjct: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDI 1432



 Score =  348 bits (892), Expect = 8e-95
 Identities = 213/556 (38%), Positives = 303/556 (54%), Gaps = 4/556 (0%)

Query: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH A++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
           LL +   L   TK G + LH+AA     E V+ L+ + A V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437
             V K LL+  AN N    +GFTPL +A ++    V+  L+ YG       +  L  +H+
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHI 179

Query: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
           AA         +LLQN  +PDV +  G T LH+AA    + V + LL  GA V+   +  
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
            TPLHIASR G   +V+LLL   A  +  T +  TPLH +AR G V ++ +LL+ GA   
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
             TK G +P+H+AA+   LD  +LLLQ  A  D    + LTPLHVAAH  + +VA +LL+
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
           KGA P++ A NG+TPLHIA KKN +++   LL  GA  + VT+ G+TPLH+AS  GH  +
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
           V  LL +GA+ ++S     T LH+AA+     VA  L ++ A  +A  K   TPL  A  
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
            G+  MV  LL+  AN N  T  G+TPLH AA++GH   +  LL+  A     T  G T 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 798 LAIAKRLGYISVVDTL 813
           L +A + G + V + L
Sbjct: 540 LHVAAKYGKVRVAELL 555



 Score =  201 bits (512), Expect = 9e-51
 Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)

Query: 15  KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74
           K+   ++ +   K  D       AAR G+ + V   L+   + N     G   LH+AA+E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 75  GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
           GHV  V  LL + +S    TKKG T LH+A+  G+  V ++L++  A+ NA  +NG TPL
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192
           ++A   N++D+VK LL  G +  +   +G+TPL +A +Q   +    LL+          
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
             +  LH+AA++   +  ALLL    N ++ +K        SG TPLH+ A  G+V VA 
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685

Query: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
           +L+  G  VD T R G TPLHVAS  GN  +VK LL     ++AKT+ G +PLH AA+ G
Sbjct: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745

Query: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339
           H  +V LLL+ GA     + +G +PL +A
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 95.5 bits (236), Expect = 9e-19
 Identities = 49/121 (40%), Positives = 79/121 (65%), Gaps = 1/121 (0%)

Query: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626
            E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL  W+ R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460

Query: 3627 HATDTNLVECLTKINRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE 3685
            +A   NL   L  I+R +IV+++E +  +    +    + + + +++     G+S LQ+E
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520

Query: 3686 L 3686
            L
Sbjct: 1521 L 1521



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 19/48 (39%), Positives = 30/48 (62%)

Query: 3870 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 3917
            +G++   IP E VTEE++ DE G+ V KK+ RK++R+   S     +E
Sbjct: 1798 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1845


>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
          Length = 1001

 Score =  838 bits (2165), Expect = 0.0
 Identities = 416/619 (67%), Positives = 493/619 (79%), Gaps = 42/619 (6%)

Query: 849  EGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSH 908
            + +D MTGD  +YL P+DLKELGDDSLP+        Y+ +SL G RS SLRSFSSDRS+
Sbjct: 5    QSEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRSFSSDRSY 57

Query: 909  TLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALSSSPIHSG 967
            TL+ +SY RDS ++++ +V    Q  T  +E + +S R  SW  + LDNV L SSPIHSG
Sbjct: 58   TLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSG 117

Query: 968  FLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLA 1027
            FLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA            
Sbjct: 118  FLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLAN----------- 166

Query: 1028 SRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAAL 1087
                                  PPP+ EGE L SR++++GP G +FLGPVIVEIPHF ++
Sbjct: 167  ----------------------PPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSM 204

Query: 1088 RGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDF 1147
            RGKEREL+VLRSENG++WKEH  D   ++L E+LNGMDE LDSPE+L KKRICRIIT+DF
Sbjct: 205  RGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDF 264

Query: 1148 PQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVK 1207
            PQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVGLQAQP+  E+VK
Sbjct: 265  PQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVK 324

Query: 1208 KILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA-PTLRLLCSITG 1266
            KILGNKATFSPIVT+EPRRRKFHKPITMTIPVP  S + + NG+ GD  P LRLLCSITG
Sbjct: 325  KILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITG 384

Query: 1267 GTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPY 1326
            GT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V  A+Q+YRE+ICVPY
Sbjct: 385  GTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPY 444

Query: 1327 MAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCF 1386
            MAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+EVLEGKPIYVDC+
Sbjct: 445  MAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCY 504

Query: 1387 GNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAIC 1446
            GNL PLTK GQ  +F+F++FKENRLP  +K+RDT+QEPCGRLSF+KEPK+T+GL   A+C
Sbjct: 505  GNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVC 564

Query: 1447 NLNITLPIYTKESESDQEQ 1465
            NLNITLP + K  ++D+ Q
Sbjct: 565  NLNITLPAHKKIEKTDRRQ 583



 Score =  125 bits (315), Expect = 6e-28
 Identities = 138/527 (26%), Positives = 220/527 (41%), Gaps = 92/527 (17%)

Query: 3397 LDSKTKCPVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGG 3456
            ++S  +C   T    +   E +E  EE+    +              ++ +     C G 
Sbjct: 458  VESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEV-----------LEGKPIYVDCYGN 506

Query: 3457 TSP-TKESKEHFFDLY---RNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALE 3512
             +P TK  ++  F+ Y    N + F  +I D + +   RL+        + + +++  L 
Sbjct: 507  LAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLS-------FLKEPKTTKGLP 559

Query: 3513 VSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEER 3572
             + + NL      H   E   D R    +S  +L  R       +    PQ   ER + R
Sbjct: 560  QTAVCNLNITLPAHKKIEKT-DRR----QSFASLALRKRYSYLTEPGMSPQSPCERTDIR 614

Query: 3573 LAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTN 3632
            +A +ADHLG SWTELAREL+F+ ++I+QIR+ENPNSL  QS  LLK W+ RDGK+AT   
Sbjct: 615  MAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDA 674

Query: 3633 LVECLTKINRMDIVHLMETNTEPLQE--RIS--HSYAEIEQTITLDHSEGFSVLQEELCT 3688
            L   LTKINR+DIV L+E    P+ +   IS   S+A+ E  +  D  +G+  LQ EL T
Sbjct: 675  LTSVLTKINRIDIVTLLE---GPIFDYGNISGTRSFAD-ENNVFHDPVDGYPSLQVELET 730

Query: 3689 A-----------QHKQKEEQAVSKES--------------------ETCDHPPIVSEEDI 3717
                        Q         S ES                     + D PP+V+ ED 
Sbjct: 731  PTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDA 790

Query: 3718 SVGYSTFQDGVPKTE--------------------GDSSATALFPQTHKEQVQQDFSGKM 3757
            S+  S  +D VP TE                     ++S+  L       +V      ++
Sbjct: 791  SLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRL 850

Query: 3758 QDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTPAEEEKLYLQTP 3815
             D P++   +    Y     G   +      I P + +K+  PE  +   ++       P
Sbjct: 851  DDSPDQCR-DSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKP 909

Query: 3816 TSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERL 3862
               +  GS  ++EP  P    ++S    + L+I E+    P + +++
Sbjct: 910  ---KIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKM 953


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  327 bits (839), Expect = 1e-88
 Identities = 248/808 (30%), Positives = 385/808 (47%), Gaps = 43/808 (5%)

Query: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
           RA  + + + V   LK   D+N  ++N    LH+AA    V   + L+   S+V+ + + 
Sbjct: 80  RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139

Query: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
           G TALH A+ +G  E+VK+L+  GANINA  +     ++ AA   HI+VVK L+ +GA  
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199

Query: 157 STATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALL 211
           +   +  +TPL  A   G    V  LL+     N+       P LH+A            
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP-LHVACYNGQDVVV--- 255

Query: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPL 270
                N  +    +VN+  E GFTPLH AA   +  +   LL+  GA V+  +++G TPL
Sbjct: 256 -----NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310

Query: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
           H+ +  G  +  + ++  G  ID + ++G TPLH AAR GH+ ++  L+  GA    R  
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370

Query: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
           +G+ PLH+AA     +C + LL     +D       T LH AA  G+     LLL+  A+
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430

Query: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL-L 449
            N +   G +PLH A      + +  LV  GAS+  + E G TP+H AA        L  
Sbjct: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490

Query: 450 LLQNGASPDVTNIRGETALHMAARAGQ------------VEVVRCLLRNGALVDARAREE 497
           LL+N A+P + + +G  A+H +A  G             ++V+        L D+  R  
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
            +PLH+A+  G  + +++L+Q +   D   ++G TPL ++A +G V+   VL+  GA  S
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--S 608

Query: 558 LATKKGF---TPLHVAAKYGSLDVAKLLL---QRRAAADSAGKNGLTPLHVAAHYDNQKV 611
           +  K      TP+H AA  G  +  +LL+   + + A D    NG TPL ++    +   
Sbjct: 609 ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDC 668

Query: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
              LL KGA+  A  K G T LH  A     +    LL +GA+  +   +G TP+HL++ 
Sbjct: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAA 728

Query: 672 EGHTDMVTLLLDKGANIHMSTKS----GLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 727
            GH  ++  LL   A++  +  +    G T+LH A         ++L +    Q      
Sbjct: 729 CGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN- 787

Query: 728 GYTPLIVACHYGNVKMVNFLLKQ-GAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 785
            ++PL  A    N      L+   GA+ VNA    G TPLH AA   H   + +LL H A
Sbjct: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847

Query: 786 KPNATTANGNTALAIAKRLGYISVVDTL 813
           + N+  + G T L +A   G  + V+ L
Sbjct: 848 QVNSVDSTGKTPLMMAAENGQTNTVEML 875



 Score =  313 bits (803), Expect = 2e-84
 Identities = 246/764 (32%), Positives = 386/764 (50%), Gaps = 46/764 (6%)

Query: 36  LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94
           L AA +  +  VV+YL   G+D+N  N  G   LH+A   G   +V EL+  G+ V+   
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269

Query: 95  KKGNTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
           +KG T LH A+ +    + +++LV  GA++N +S++G TPL+M A        + ++++G
Sbjct: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 329

Query: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAA 209
           A      ++G TPL +A + GH   +  L+ +  DT  +G   +  LH+AA    +    
Sbjct: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389

Query: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
            LL +  + D           + G T LH AA  GN+    LLLN GA  +   + G +P
Sbjct: 390 KLLSSGFDIDTPD--------DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441

Query: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD-QVVELLLERGAPLLAR 328
           LH A+   N   +  L+  G  ++     G TPLH AA S  D + +E LL   A    R
Sbjct: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501

Query: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVD--------DVTLDY-----LTALHVAAHC 375
            K G + +H +A   H  C++ L+  + P+D        D+  D      ++ LH+AA+ 
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQ-LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYH 560

Query: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL--T 433
           GH++  ++L+    + + R  +G TPL +A  K  ++ +++L+  GASI  + +  L  T
Sbjct: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYILKRT 619

Query: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIR---GETALHMAARAGQVEVVRCLLRNGALV 490
           PIH AA  GH   + LL+ N    +  +I+   G+T L ++   G  + V  LL  GA V
Sbjct: 620 PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679

Query: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
           DA+ +  +T LH  +  G  E V  LLQH A      + G TP+H+SA  G + V   LL
Sbjct: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 739

Query: 551 EAGAAH----SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606
           ++ A+     + A   G+T LH A   G     +LLL++     + G N  +PLH A   
Sbjct: 740 QSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVIN 798

Query: 607 DNQKVALLLLEK-GAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
           DN+  A +L++  GAS  +AT   G TPLH AA  + ++    LL++ A+ N V   G T
Sbjct: 799 DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKT 858

Query: 665 PLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD- 722
           PL +A++ G T+ V +L+    A + +   S  T+LHLA  +     A ++ +   D++ 
Sbjct: 859 PLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918

Query: 723 --AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
             A      TPL VA   G   +V  LL +GA+V A  +NGYTP
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962



 Score =  297 bits (761), Expect = 1e-79
 Identities = 236/777 (30%), Positives = 363/777 (46%), Gaps = 38/777 (4%)

Query: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
           S ++A   G+ D+V   +    D+N  +      LH AA  G   +++ L+  G+ V++ 
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
             K  T LH A  +   E V+VL+K  A++NA+ +N  TPL++AA    +   + L+   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAA 209
           +N + +   G T L  A   GH + V +LL          K    A+H AA     +   
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
           LL+   H A+V  K       +  +TPLH AA  G ++V   LL+ G  ++     G TP
Sbjct: 191 LLV--SHGAEVTCK------DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242

Query: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLAR 328
           LHVA   G   +V  L+D G  ++ K   G TPLH AA S H  + +ELL+  GA +  +
Sbjct: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302

Query: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
           +K+G +PLHM A        + ++Q  A +D    +  T LH+AA  GH  +   L+   
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362

Query: 389 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
           A+   R ++G  PLH+A           L+  G  I    + G T +H AA  G+L  + 
Sbjct: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422

Query: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508
           LLL  GA  +  +  G + LH AA     + +  L+ +GA V+       TPLH A+   
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482

Query: 509 KT-EIVQLLLQHMAHPDAATTNGYTPLHISAREG---------QVDVASVLLEAGAAHSL 558
              + ++ LL++ A+P      GY  +H SA  G               VL+E      L
Sbjct: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542

Query: 559 A---TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
           +    +   +PLH+AA +G     ++L+Q     D    +G TPL +AA   + +   +L
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602

Query: 616 LEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLA 669
           + +GAS     K+     TP+H AA     +    L+      N V  Q   G TPL L+
Sbjct: 603 INQGAS--ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660

Query: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
              GHTD V  LL+KGAN+    K G T+LH  A        D L +HGA        G 
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720

Query: 730 TPLIVACHYGNVKMVNFLLKQGANVNAK----TKNGYTPLHQAAQQGHTHIINVLLQ 782
           TP+ ++   G++ ++  LL+  A+++A       +GYT LH A   GH   + +LL+
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777



 Score =  277 bits (708), Expect = 2e-73
 Identities = 217/702 (30%), Positives = 305/702 (43%), Gaps = 92/702 (13%)

Query: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
           LH AA   D +   LL        + S   VN       TPLH A    +     +LL  
Sbjct: 45  LHAAAYLGDAEIIELL--------ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96

Query: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
            A V+   +N  TPLH+A+        + L+     ++   R G T LH AA SGH ++V
Sbjct: 97  SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMV 156

Query: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
           +LLL RGA + A  K     +H AA   H+E VK L+ H A V        T LH AA  
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216

Query: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
           G   V K LLD   + N     G TPLH+AC   +  V+  L+  GA +    E G TP+
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276

Query: 436 HVAAFMGHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
           H AA   H  + L LL+ NGA  ++ +  G+T LHM A  G+    + ++++GA++D   
Sbjct: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336

Query: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
           +   TPLHIA+R G   ++  L+   A       +G  PLH++A  G  D    LL +G 
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396

Query: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614
                   G T LH AA  G+L+   LLL   A  +   K G +PLH AA   N +    
Sbjct: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456

Query: 615 LLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAETNIVTKQG----------- 662
           L+  GAS +   + G TPLH AA  +   +    LL   A   I  KQG           
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 516

Query: 663 ----------------------------------VTPLHLASQEGHTDMVTLLLDKGANI 688
                                             ++PLHLA+  GH   + +L+    ++
Sbjct: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576

Query: 689 HMSTKSGLTSLHLAAQEDKVNVADILTK-----------------HGADQDAHTKL---- 727
            +   SG T L LAA +  V   D+L                   H A  + H++     
Sbjct: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636

Query: 728 ----------------GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 771
                           G TPL+++   G+   V  LL +GANV+AK K G T LH+ A  
Sbjct: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT 696

Query: 772 GHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           GH   ++ LLQHGAK     + G T + ++   G+I V+  L
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738



 Score =  261 bits (666), Expect = 1e-68
 Identities = 183/584 (31%), Positives = 289/584 (49%), Gaps = 14/584 (2%)

Query: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303
           G+ +    L+ +   V+F      TPLH A+  G+  +++LL+  G +++AK    LTPL
Sbjct: 19  GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78

Query: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363
           H A  S  ++ V++LL+  A + AR KN  +PLH+AA    V+C + L+   + V+    
Sbjct: 79  HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138

Query: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
              TALH AA  GH  + KLLL + AN NA        +H A     I+V++LLV +GA 
Sbjct: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198

Query: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
           +    +   TP+H AA  G +++V  LL  G   +  N  G T LH+A   GQ  VV  L
Sbjct: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258

Query: 484 LRNGALVDARAREEQTPLHIASRLGKTEI-VQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
           +  GA+V+ +  +  TPLH A+      + ++LL+ + A  +  + +G TPLH++A  G+
Sbjct: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318

Query: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
              +  ++++GA      K G TPLH+AA+YG   +   L+   A     G +G+ PLH+
Sbjct: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378

Query: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662
           AA          LL  G         G T LH AA    ++  + LLN GA+ N   K G
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438

Query: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED-KVNVADILTKHGADQ 721
            +PLH A+   +   +  L+  GA+++   + G T LH AA  D      + L ++ A+ 
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498

Query: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQ----------GANVNAKTKNGYT--PLHQAA 769
               K GY  +  +  YG+   +  +  +          G ++ + + N  T  PLH AA
Sbjct: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558

Query: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
             GH   + VL+Q     +   ++G T L +A   G++  VD L
Sbjct: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602



 Score =  244 bits (624), Expect = 9e-64
 Identities = 213/711 (29%), Positives = 329/711 (46%), Gaps = 59/711 (8%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           K  D        A  G   +    ++ G  I+  ++NG   LH+AA+ GH  L+  L+  
Sbjct: 302 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 361

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
           G+        G   LH+A+L+G ++  + L+  G +I+     G T L+ AA   +++ +
Sbjct: 362 GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421

Query: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL-----ENDTKGKVRLPALHIAAR 201
             LL  GA+ +   + G +PL  A    + Q +  L+      ND   +   P LH AA 
Sbjct: 422 NLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTP-LHYAAT 480

Query: 202 KD-DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
            D D K    LL+ND N  ++ K         G+  +H +A YG+     L+ +      
Sbjct: 481 SDTDGKCLEYLLRNDANPGIRDK--------QGYNAVHYSAAYGHRLCLQLIASE----- 527

Query: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
                  TPL V  +   T+M+          D+  R  ++PLH AA  GH Q +E+L++
Sbjct: 528 -------TPLDVLMETSGTDMLS---------DSDNRATISPLHLAAYHGHHQALEVLVQ 571

Query: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL---TALHVAAHCGH 377
               L  R  +G +PL +AA   HVECV  L+   A +  +  DY+   T +H AA  GH
Sbjct: 572 SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI--LVKDYILKRTPIHAAATNGH 629

Query: 378 YRVTKLLLDKRANPNARAL---NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 434
               +LL+      NA  +   NG TPL ++        +  L+  GA++ A  + G T 
Sbjct: 630 SECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA 689

Query: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
           +H  A  GH   V  LLQ+GA   + + RG T +H++A  G + V+  LL++ A +DA  
Sbjct: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANP 749

Query: 495 ----REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
                   T LH A   G    V+LLL+          N ++PLH +        A +L+
Sbjct: 750 ATADNHGYTALHWACYNGHETCVELLLEQEVF-QKTEGNAFSPLHCAVINDNEGAAEMLI 808

Query: 551 EA-GAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN 608
           +  GA+   AT  KG TPLH AA    ++  +LLL   A  +S    G TPL +AA  + 
Sbjct: 809 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE-NG 867

Query: 609 QKVALLLLEKGASPHATAKNG--YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV--- 663
           Q   + +L   AS   T ++    T LH+A  K     A  +L    + N++        
Sbjct: 868 QTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ 927

Query: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
           TPLH+A++ G T +V  LL KGA++    ++G T   LA   +K +VAD L
Sbjct: 928 TPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPA-LACAPNK-DVADCL 976



 Score =  187 bits (474), Expect = 2e-46
 Identities = 124/370 (33%), Positives = 184/370 (49%), Gaps = 1/370 (0%)

Query: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
           A F G  + V  L+      +  +    T LH AA  G  E++  L+ +GA V+A+  + 
Sbjct: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
            TPLH A      E VQ+LL+H A  +A   N  TPLHI+A    V  A  L+   +  +
Sbjct: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134

Query: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
           ++ + G T LH AA  G  ++ KLLL R A  ++  K     +H AA+  + +V  LL+ 
Sbjct: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194

Query: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
            GA      K  YTPLH AA    + +   LL+ G + N     G TPLH+A   G   +
Sbjct: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254

Query: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKLGYTPLIVAC 736
           V  L+D GA ++   + G T LH AA      +  ++L  +GAD +  +K G TPL +  
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314

Query: 737 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 796
            +G       +++ GA ++ + KNG TPLH AA+ GH  +IN L+  GA       +G  
Sbjct: 315 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF 374

Query: 797 ALAIAKRLGY 806
            L +A   G+
Sbjct: 375 PLHLAALSGF 384



 Score =  169 bits (429), Expect = 4e-41
 Identities = 113/353 (32%), Positives = 178/353 (50%), Gaps = 1/353 (0%)

Query: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521
           +R + +L  A   G  + VR L+     V+ +  E++TPLH A+ LG  EI++LL+   A
Sbjct: 6   LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65

Query: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 581
             +A  +   TPLH +      +   VLL+  A  +   K   TPLH+AA   ++  A+ 
Sbjct: 66  RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125

Query: 582 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 641
           L+   +  + + + G T LH AA   + ++  LLL +GA+ +A  K     +H AA    
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185

Query: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701
           +++   L+++GAE     K+  TPLH A+  G   +V  LLD G +++     G T LH+
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245

Query: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPL-IVACHYGNVKMVNFLLKQGANVNAKTKN 760
           A    +  V + L   GA  +   + G+TPL   A        +  L+  GA+VN K+K+
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305

Query: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           G TPLH  A  G       ++Q GA  +    NGNT L IA R G+  +++TL
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358



 Score = 89.7 bits (221), Expect = 5e-17
 Identities = 57/168 (33%), Positives = 78/168 (46%)

Query: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
           + N    +  TPLH A+  G  +++ LL+  GA ++      LT LH A          +
Sbjct: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92

Query: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
           L KH AD +A  K   TPL +A     VK    L+   +NVN   + G T LH AA  GH
Sbjct: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152

Query: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821
             ++ +LL  GA  NA       A+  A  +G+I VV  L     EVT
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT 200


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  314 bits (805), Expect = 1e-84
 Identities = 266/829 (32%), Positives = 389/829 (46%), Gaps = 89/829 (10%)

Query: 65   LNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANIN 124
            +  L  AA  GHV +V+ LL   + V++ +  GNTAL  A   G  +VVKVL++ GA+I 
Sbjct: 302  ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361

Query: 125  AQSQNGFTPLYMAAQENHIDVVKYLLENGANQST-ATEDGFTPLAVALQQGHNQAVAILL 183
              ++NG TPL  A    H++V + LLENGA  +T + E   + L +A  +GH + V  LL
Sbjct: 362  DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421

Query: 184  ENDTKGKVRLPALHIA---ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
            E     + +   +H A   A  D     A LL       + S   VN   +S  +PL +A
Sbjct: 422  EAGADQEHKTDEMHTALMEACMDGHVEVARLL-------LDSGAQVNMPADSFESPLTLA 474

Query: 241  AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG- 299
            A  G+V +A LL+ RGA+++     G TPL  A++ G+  MV LLL +G  I+A+T +  
Sbjct: 475  ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ 534

Query: 300  ------------------------------LTPLHCAARSGHDQVVELLLERGAPLLART 329
                                           TPL  AA+ GH ++V+ LL  GA + A T
Sbjct: 535  ETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594

Query: 330  KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
              G + L  A +  H +    LLQ  A ++  +    T L  AA  GH    + L+ K A
Sbjct: 595  ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654

Query: 390  NPN-ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
            N N   A N  T L +AC    + V+ELL+ +GA      + G T +  AA  GH ++V 
Sbjct: 655  NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714

Query: 449  LLLQ------NGASPDVTNIRGETALHMAARAGQVEV--------------------VRC 482
             LL       +   PDVT +   +  H   RA +V V                       
Sbjct: 715  YLLDYPNNLLSAPPPDVTQLTPPS--HDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772

Query: 483  LLRNGALVDARAREEQTPLH-IASRLGKTEI----------VQLLLQHMAHPDAAT-TNG 530
             +RN A+    +    TP H IA+ + + +             L +      DA T +N 
Sbjct: 773  PIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNH 832

Query: 531  YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
             T L ++   G  ++   LLE GA+     KKGFTPL +AA  G + V ++LL   A  +
Sbjct: 833  DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892

Query: 591  SAGKNGL-TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
            +  +    TPL +A     Q+V  LLL +GA+      + YTPL +AA    + I   LL
Sbjct: 893  AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952

Query: 650  NYGAETNIVT--KQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQED 706
            N GAE N  T  K G++PL LA+  GHT  V LLLD G++I+   ++   T+L LA  + 
Sbjct: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012

Query: 707  KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK--TKNGYTP 764
            +  V  +L    A+ +   K G TPL+ A   G  ++   LL +GA+VNA     +  T 
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072

Query: 765  LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
            L  AA +GH     +L+  GA  +     GNT L +A   G++ VV  L
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121



 Score =  308 bits (788), Expect = 9e-83
 Identities = 259/810 (31%), Positives = 386/810 (47%), Gaps = 52/810 (6%)

Query: 32   NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
            N S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+
Sbjct: 235  NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294

Query: 92   SATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
                KG+ T L  A+  G  ++VK+L+   A++NAQS  G T L  A    ++DVVK LL
Sbjct: 295  DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354

Query: 151  ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDT 205
            E+GA+     E+G TPL  A   GH +   +LLEN         + +  AL +A  K   
Sbjct: 355  ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 206  KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
            +    LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +
Sbjct: 415  EMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466

Query: 266  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
              +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA +
Sbjct: 467  FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 326  LARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
             A+T+    + L +A  G  +E    L++  A   D+ L   T L  AA  GH  + K L
Sbjct: 527  NAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYL 583

Query: 385  LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
            L   AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GH+
Sbjct: 584  LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643

Query: 445  NIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
              V  L+  GA+ + T    + T L +A   G + VV  LL +GA    R ++  T L  
Sbjct: 644  CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703

Query: 504  ASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559
            A++ G T +V  LL +    ++ P    T    P H   R  +V V ++ +         
Sbjct: 704  AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM--------- 754

Query: 560  TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH-VAAHYDNQKV------- 611
                  P     K  +     L ++ +A +  A     TP H +AA     +        
Sbjct: 755  ----VVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII 810

Query: 612  ---ALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667
               A+L +       A T  N  T L +A      ++  TLL  GA      K+G TPL 
Sbjct: 811  SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 870

Query: 668  LASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
            LA+  GH  +V +LLD GA+I   S ++  T L LA    +  V ++L   GA+++    
Sbjct: 871  LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930

Query: 727  LGYTPLIVACHYGNVKMVNFLLKQGANVNAKT--KNGYTPLHQAAQQGHTHIINVLLQHG 784
              YTPL +A   G V ++  LL  GA +N++T  K G +PL  AA  GHT  + +LL  G
Sbjct: 931  SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990

Query: 785  AKPNA-TTANGNTALAIAKRLGYISVVDTL 813
            +  NA    N NTAL +A   G   VV  L
Sbjct: 991  SDINAQIETNRNTALTLACFQGRTEVVSLL 1020



 Score =  296 bits (759), Expect = 2e-79
 Identities = 287/1018 (28%), Positives = 462/1018 (45%), Gaps = 110/1018 (10%)

Query: 30   DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
            + +   + A  AG+++     L+ G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 366  NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425

Query: 89   SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
              +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 426  DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485

Query: 149  LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
            L+E GA+     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 486  LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA---------NINAQTEETQET 536

Query: 209  ALLL--------------------------------QNDHNADVQSKMM----VNRTTES 232
            AL L                                Q  H   V+  +     V+ TT +
Sbjct: 537  ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTAT 596

Query: 233  GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
            G T L  A   G+ +VA +LL  GA ++  +  G TPL  A++ G+   V+ L+ +G  +
Sbjct: 597  GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656

Query: 293  DAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
            +  T +   T L  A   GH  VVELLL  GA    R K+G + L  AA+G H   V +L
Sbjct: 657  NRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716

Query: 352  LQH-----KAPVDDVTL------DYLTALHVAAHC--------------GHYRVTKLLLD 386
            L +      AP  DVT       D   A  V                   +   T  + +
Sbjct: 717  LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRN 776

Query: 387  KRANPNARALNGFTPLH-IACKKNR---------IKVMELLVKYGA-SIQAITESGL-TP 434
            K  +  A A++  TP H IA   ++         I    +L  Y A  I A TES   T 
Sbjct: 777  KAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTA 835

Query: 435  IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
            + +A   GH  +V  LL+ GAS +  + +G T L +AA AG V VV  LL NGA ++A++
Sbjct: 836  LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 895

Query: 495  -REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
             R + TPL +A   G+ E+V+LLL   A+ +    + YTPL ++A  G V++  +LL AG
Sbjct: 896  ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955

Query: 554  AAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQK 610
            A  +  T  K G +PL +AA  G     KLLL   +  ++  + N  T L +A      +
Sbjct: 956  AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1015

Query: 611  VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI--VTKQGVTPLHL 668
            V  LLL++ A+    AK G TPL  AA     ++   LL+ GA+ N   V     T L +
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075

Query: 669  ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
            A+ +GH     LL+ +GA+I +  K G T L LAA    ++V  +L + GAD DA     
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135

Query: 729  YTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
             TPL+ A   G+VK+V +L+K+      +++       +         H+    +     
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKD 1195

Query: 787  PNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH------KLNVPETMT 840
              A  AN N ++ + +       +D  K+  E          EK       K        
Sbjct: 1196 RQAAEANKNASILLEE-------LDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKL 1248

Query: 841  EVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFLDGMNYLRYSLEGG---RS 896
            E ++  ++E  +       E L+ ED  E L +    ++    G++    +L G    R+
Sbjct: 1249 EEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRN 1308

Query: 897  DSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENL 954
            +++ + SS R +  +  +      + DD + I   Q   +  E++ +S   S  ++N+
Sbjct: 1309 NTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNM 1366



 Score =  199 bits (506), Expect = 5e-50
 Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)

Query: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
           KA  D   L  LT+   +  C        L   RA   A A  +    L  AC +  +  
Sbjct: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249

Query: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 472
           +  L+  G S+   TE G + + +A   G+  +  +LL   A+ +   I+G+ T L  AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309

Query: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532
             G V++V+ LL + A V+A++    T L  A   G  ++V++LL+  A  +    NG+T
Sbjct: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369

Query: 533 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
           PL  +   G V+VA +LLE GA    HS   K+  + L +A   G L++ + LL+  A  
Sbjct: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427

Query: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
           +       T L  A    + +VA LLL+ GA  +  A +  +PL +AA    +++A+ L+
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487

Query: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 708
             GA    V  +G TPL  A++EGH +MV LLL +GANI+  T+    T+L LA     +
Sbjct: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547

Query: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
            VAD L K GAD +       TPL+ A   G++++V +LL  GANV+A T  G T L  A
Sbjct: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604

Query: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828
            + GHT + +VLLQ GA     +  G T L  A R G++  V  L  +++      TT  
Sbjct: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662

Query: 829 EKH 831
             H
Sbjct: 663 NDH 665



 Score =  163 bits (412), Expect = 4e-39
 Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)

Query: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
            +S+ + +   A   G+ + V   L+ G  I   ++ G   L LAA  GHVG+V+ LL  G
Sbjct: 829  ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888

Query: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
            + +++ +++  +T L +A   G+ EVV++L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 889  ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948

Query: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 949  KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008

Query: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
              +  T+  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1060

Query: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  AA  GH  VV+L
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120

Query: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1174



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 2/95 (2%)

Query: 26   PKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 84
            P  S  + +   AA  G+  K  E L G G  I+  N+ G   L LAA  GH+ +VQ L+
Sbjct: 1064 PVPSSRDTALTIAADKGHY-KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1122

Query: 85   GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
              G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 1123 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157



 Score = 42.0 bits (97), Expect = 0.012
 Identities = 57/238 (23%), Positives = 97/238 (40%), Gaps = 18/238 (7%)

Query: 1701 KKPVRRKLKEKQKQKEEGLQA-SAEKAELKKGSSEESL--GEDPGLAPEPLPTVKATSPL 1757
            +K  RRK KE+Q++K E ++A + E  EL+    +E L   ++P +  EP      T+  
Sbjct: 1233 RKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIG 1292

Query: 1758 IE---ETPIGSIKDKVKALQKRVEDEQKGRSKL-PIRVKGKEDVPKKTTH-RPHPAASPS 1812
            I     T  GS   +   +       +  ++K+ P  V+   D P   ++ +P      S
Sbjct: 1293 ISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGES 1352

Query: 1813 LKSERHAPGSP-----SPKTERHSTLSSSAKTERHPP--VSPSSKTEKHSPVSPSAKTER 1865
              S     G       S  ++  S  +SS K++ H P  V+ +  ++K   V  +   E 
Sbjct: 1353 KSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEE 1412

Query: 1866 HSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTE 1923
                S  +  +    +S  T    +S  + TK+   P  SP+GK     P     R E
Sbjct: 1413 RKSVSGKASIKLSETISEGTS---NSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREE 1467



 Score = 38.5 bits (88), Expect = 0.13
 Identities = 43/151 (28%), Positives = 59/151 (39%), Gaps = 20/151 (13%)

Query: 1798 PKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPV 1857
            P  T    +P +SPS  S    PG  S    R+S L   + +     V+ SS+ E  SP 
Sbjct: 1779 PMPTAKEHYPVSSPSSPSPPAQPGGVS----RNSPLDCGSASPN--KVASSSEQEAGSP- 1831

Query: 1858 SPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPP-----VSPSGKTDK 1912
             P  +T    P +SSS     S  S S  + +  P  S   E  PP     V P      
Sbjct: 1832 -PVVETTNTRPPNSSS-----SSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 1885

Query: 1913 RPPVSPSGRTEKHPPVSPGRTEKRLPVSPSG 1943
             PP++ S      P  +P      +P +P G
Sbjct: 1886 VPPLATSSAPVAVPSTAP--VTYPMPQTPMG 1914



 Score = 35.4 bits (80), Expect = 1.1
 Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 33/204 (16%)

Query: 1801 TTHRPHPAASPSLKSERHAPGSPSPKTERHSTL--SSSAKTERHPPVSPSSKTEKHSPVS 1858
            TT     A++    S   +P SPS + +   T+  +S+A T      + ++ T   +   
Sbjct: 1719 TTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATY 1778

Query: 1859 PSAKTERHSPASSSSK---------TEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGK 1909
            P    + H P SS S            ++SP+   + +      SS +    PPV  +  
Sbjct: 1779 PMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET-- 1836

Query: 1910 TDKRPP--VSPSGRTEKH---------------PPVSPGRT---EKRLPVSPSGRTDKHQ 1949
            T+ RPP   S SG +  H               PP+   +    E R+ V P   +    
Sbjct: 1837 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV 1896

Query: 1950 PVSTAGKTEKHLPVSPSGKTEKQP 1973
             V +       +P +P G  +  P
Sbjct: 1897 AVPSTAPVTYPMPQTPMGCPQPTP 1920


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  308 bits (789), Expect = 7e-83
 Identities = 250/787 (31%), Positives = 364/787 (46%), Gaps = 97/787 (12%)

Query: 26  PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQEL 83
           P  S +    L A R G++ +V + L    ++N  +  G  +  LH AA  G   +V+ L
Sbjct: 177 PAVSGALRELLEACRNGDVSRV-KRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHL 235

Query: 84  LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
           L  G++V +    G   LH A   G AEVV +L+ +GA+ NA+    +TPL+ AA +  I
Sbjct: 236 LQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295

Query: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
           DV   LL++GA+ +    DG +    AL      A A+L      G+ +   L  AAR  
Sbjct: 296 DVCIVLLQHGADPNIRNTDGKS----ALDLADPSAKAVL-----TGEYKKDELLEAARSG 346

Query: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDF 261
           + +    LL         + + VN     G   TPLH+AA Y  V +  LLL  GA V  
Sbjct: 347 NEEKLMALL---------TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397

Query: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
             + G+ PLH A   G+  + +LLL  G  ++A      TPLH AA     +V  LLL  
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457

Query: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKH------LLQHKAPVD------DVTLDYL--- 366
           GA       +G S + MA   +  E + +      LLQ     D       + L+ +   
Sbjct: 458 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFK 517

Query: 367 ------TALHVAA---HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417
                 TALH A    H    +VT+LLL K AN N +  +  TPLH+A ++    VME+L
Sbjct: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577

Query: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM------- 470
            K+GA + A+   G T +H AA  GHL    LLL  G+ P + +++G TA  M       
Sbjct: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637

Query: 471 -------------------AARAGQVEVVR--CLLRNGALVDARAREEQTPLHIASRLGK 509
                              A++AG +E V+  C  +N    D   R   TPLH A+   +
Sbjct: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGR-HSTPLHFAAGYNR 696

Query: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
             +V+ LL H A   A    G  PLH +   G  +VA +L+  GA+ ++A    FTPLH 
Sbjct: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756

Query: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN----------------QKVAL 613
           AA  G  ++ KLLL+  A      ++G TPL +    D                 +K  L
Sbjct: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCL 816

Query: 614 LLLEKGASP-----HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL 668
             ++K  +P       T     TPLH+AA  N +++A  LL +GA+ N   K G+ PLH 
Sbjct: 817 ARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN 876

Query: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
           A+  GH D+  LL+     ++ + K   T LH AAQ+ +  +  +L  HGAD     + G
Sbjct: 877 AASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEG 936

Query: 729 YTPLIVA 735
            TPL +A
Sbjct: 937 QTPLDLA 943



 Score =  236 bits (601), Expect = 4e-61
 Identities = 213/709 (30%), Positives = 303/709 (42%), Gaps = 111/709 (15%)

Query: 186 DTKGKVRLPALHIAA---RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
           D  G+   P LH AA   RKD  +    +  N H  D           + G  PLH A  
Sbjct: 211 DMAGRKSSP-LHFAAGFGRKDVVEHLLQMGANVHARD-----------DGGLIPLHNACS 258

Query: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
           +G+  V +LLL +GA  +       TPLH A+ +G  ++  +LL  G   + +  DG + 
Sbjct: 259 FGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSA 318

Query: 303 LHCA--------------------ARSGHDQ-VVELLLERGAPLLARTKNGLSPLHMAAQ 341
           L  A                    ARSG+++ ++ LL        A      +PLH+AA 
Sbjct: 319 LDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAG 378

Query: 342 GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTP 401
            + V  V+ LLQH A V       L  LH A   GHY VT+LLL   A  NA  L  FTP
Sbjct: 379 YNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTP 438

Query: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA-----------FMGHLNIVLLL 450
           LH A  KNR++V  LL+ +GA    +   G + + +A            F GH      L
Sbjct: 439 LHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS-----L 493

Query: 451 LQNGASPDVTNIRG---------------ETALHMAARA---GQVEVVRCLLRNGALVDA 492
           LQ     D+  ++                ETALH A  +    + +V   LLR GA V+ 
Sbjct: 494 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE 553

Query: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552
           + ++  TPLH+A+     +++++L +H A  +A  T G T LH +A  G +    +LL  
Sbjct: 554 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 613

Query: 553 GAAHSLATKKGFTPLHV--------------------------AAKYGSLDVAKLLL--Q 584
           G+  S+ + +GFT   +                          A+K G L+  K L   Q
Sbjct: 614 GSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ 673

Query: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
                D  G++  TPLH AA Y+   V   LL  GA  HA  K G  PLH A      ++
Sbjct: 674 NVNCRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEV 732

Query: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
           A  L+ +GA  N+      TPLH A+ +G  ++  LLL  GA+     + G T L L  +
Sbjct: 733 AELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE 792

Query: 705 EDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
            D  ++ D+L    A  DA  K     +   C   N+   N    QG N         TP
Sbjct: 793 GD-TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI---NCRDTQGRNS--------TP 840

Query: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           LH AA   +  +   LL+HGA  NA    G   L  A   G++ +   L
Sbjct: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889



 Score =  235 bits (600), Expect = 6e-61
 Identities = 196/648 (30%), Positives = 295/648 (45%), Gaps = 86/648 (13%)

Query: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 93
           L AAR+GN +K++  L   +++N    +G  +  LHLAA    V +VQ LL  G+ V + 
Sbjct: 340 LEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398

Query: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
            K G   LH A   G  EV ++L+K GA +NA     FTPL+ AA +N ++V   LL +G
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458

Query: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
           A+ +     G +    A+       +   L  + KG   L A   A      K+ AL + 
Sbjct: 459 ADPTLVNCHGKS----AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514

Query: 214 NDHNADVQSKMMVNRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPL 270
           N             +  +S  T LH A    H     V  LLL +GA V+   ++ +TPL
Sbjct: 515 NF------------KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562

Query: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
           HVA++R + +++++L   G +++A    G T LH AA +GH Q   LLL  G+     + 
Sbjct: 563 HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622

Query: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
            G +   M       E V+ +L    P+    +DY   L  A+  G     K L   + N
Sbjct: 623 QGFTAAQMGN-----EAVQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCSSQ-N 674

Query: 391 PNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
            N R L G   TPLH A   NR+ V+E L+ +GA + A  + GL P+H A   GH  +  
Sbjct: 675 VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAE 734

Query: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA-------------------- 488
           LL+++GAS +V ++   T LH AA  G+ E+ + LL++GA                    
Sbjct: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD 794

Query: 489 ------------LVDARAR----------------------EEQTPLHIASRLGKTEIVQ 514
                       L+DA  +                         TPLH+A+     E+ +
Sbjct: 795 TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAE 854

Query: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
            LL+H A  +A    G  PLH +A  G VD+A++L++     +   K  FTPLH AA+ G
Sbjct: 855 YLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKG 914

Query: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622
              +  LLL   A      + G TPL +A   D + + +  +   A P
Sbjct: 915 RTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALP 962



 Score =  234 bits (597), Expect = 1e-60
 Identities = 195/613 (31%), Positives = 281/613 (45%), Gaps = 75/613 (12%)

Query: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
           A D   R   +PLH A+  G  ++V+ LL  G  + A+   GL PLH A   GH +VV L
Sbjct: 209 AKDMAGRKS-SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSL 267

Query: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA----- 372
           LL +GA   AR     +PLH AA    ++    LLQH A  +    D  +AL +A     
Sbjct: 268 LLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327

Query: 373 -AHCGHYRVTKLLLDKRA-------------NPNARALNG--FTPLHIACKKNRIKVMEL 416
               G Y+  +LL   R+             N N  A +G   TPLH+A   NR+++++L
Sbjct: 328 AVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQL 387

Query: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
           L+++GA + A  + GL P+H A   GH  +  LLL++GA  +  ++   T LH AA   +
Sbjct: 388 LLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNR 447

Query: 477 VEVVRCLLRNGA---LVDARAREE----QTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 529
           VEV   LL +GA   LV+   +       TP  +  RL        LLQ     D A   
Sbjct: 448 VEVCSLLLSHGADPTLVNCHGKSAVDMAPTP-ELRERLTYEFKGHSLLQAAREADLAKVK 506

Query: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
               L I           +  +   +H  A       LH   K     V +LLL++ A  
Sbjct: 507 KTLALEI-----------INFKQPQSHETALHCAVASLHPKRK----QVTELLLRKGANV 551

Query: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
           +   K+ +TPLHVAA   +  V  +L + GA  +A    G T LH AA    +Q    LL
Sbjct: 552 NEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL 611

Query: 650 NYGAETNIVTKQGVTPLHL--------------------------ASQEGHTDMVTLLLD 683
           +YG++ +I++ QG T   +                          AS+ G  + V  L  
Sbjct: 612 SYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS 671

Query: 684 KGANIHMSTKSGL--TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 741
              N++     G   T LH AA  ++V+V + L  HGAD  A  K G  PL  AC YG+ 
Sbjct: 672 S-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHY 730

Query: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
           ++   L++ GA+VN      +TPLH+AA +G   I  +LL+HGA P     +GNT L + 
Sbjct: 731 EVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV 790

Query: 802 KRLGYISVVDTLK 814
           K  G   + D L+
Sbjct: 791 KE-GDTDIQDLLR 802



 Score =  155 bits (392), Expect = 8e-37
 Identities = 102/288 (35%), Positives = 146/288 (50%), Gaps = 24/288 (8%)

Query: 537 SAREGQVDVASVLLEAGA--AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594
           + R G V     L++A    A  +A +K  +PLH AA +G  DV + LLQ  A   +   
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKS-SPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

Query: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
            GL PLH A  + + +V  LLL +GA P+A     YTPLH AA K ++ +   LL +GA+
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307

Query: 655 TNIVTKQGVTPLHLA--------------------SQEGHTD-MVTLLLDKGANIHMSTK 693
            NI    G + L LA                    ++ G+ + ++ LL     N H S  
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367

Query: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
              T LHLAA  ++V +  +L +HGAD  A  K G  PL  AC YG+ ++   LLK GA 
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427

Query: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
           VNA     +TPLH+AA +    + ++LL HGA P     +G +A+ +A
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475



 Score =  140 bits (353), Expect = 3e-32
 Identities = 101/319 (31%), Positives = 160/319 (50%), Gaps = 19/319 (5%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELL 84
           + SD +   L A++AG+L+  V+ L    ++N  +  G ++  LH AA    V +V+ LL
Sbjct: 646 RTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704

Query: 85  GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 144
             G+ V +  K G   LH A   G  EV ++LV+ GA++N      FTPL+ AA +   +
Sbjct: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764

Query: 145 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDD 204
           + K LL++GA+ +    DG TPL + +++G         + D +  +R  A  + A K  
Sbjct: 765 ICKLLLKHGADPTKKNRDGNTPLDL-VKEG---------DTDIQDLLRGDAALLDAAKKG 814

Query: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 264
             +    L    N + +       T     TPLH+AA Y N+ VA  LL  GA V+   +
Sbjct: 815 CLARVQKLCTPENINCRD------TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDK 868

Query: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
            G+ PLH A+  G+ ++  LL+     ++A  +   TPLH AA+ G  Q+  LLL  GA 
Sbjct: 869 GGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 928

Query: 325 LLARTKNGLSPLHMAAQGD 343
              + + G +PL +A   D
Sbjct: 929 PTMKNQEGQTPLDLATADD 947


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  307 bits (786), Expect = 2e-82
 Identities = 226/743 (30%), Positives = 352/743 (47%), Gaps = 44/743 (5%)

Query: 226  VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
            VN+   +G T L  AA+ G+++V  LL++RGA ++    +G TPL +A+++G+T +V  L
Sbjct: 538  VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597

Query: 286  LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
            +  G  I+   +DG T L  AA  GH +VV  LL  G  +     +  + L  AA G H 
Sbjct: 598  IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657

Query: 346  ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
            + V +LLQH A V+    +  TAL  AA+ GH  + + LLD  A  N   ++G T L +A
Sbjct: 658  DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717

Query: 406  C-----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
                   K    V+ LL+  GA +    + G+TP+ VAA+ GH+++V LLL+ GA  D T
Sbjct: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777

Query: 461  NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
            +  G T L  AA  G   VV  LL  GA VD+   E +T L IAS  G  E+V+ LL   
Sbjct: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837

Query: 521  AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580
               +     G+TPLH++A EG   +   L+E GA  +     G  P  +A++ G  D  +
Sbjct: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897

Query: 581  LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640
            +LL+ ++  D  G +G   L VAA   ++ +  LL   GA  +    +G   L+I A +N
Sbjct: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957

Query: 641  QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 700
            Q+ +A   L  GA       +G T LH++  +GH +MV +L+   A+++ +     ++L 
Sbjct: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017

Query: 701  LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 760
             AA +  V V  +L +HGA  D     G T L +A   G++ +V  LL+ GA+ N   + 
Sbjct: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077

Query: 761  GYTPLHQAAQQGHTHIINVLLQHGAKP-NATTANGNTALAIAKRLGYISVVDTLKVVTEE 819
            G T +  AA+ GH+ II +L ++GA   N  + +    +         S V +L + +  
Sbjct: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNS 1137

Query: 820  VTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQ 879
              +T     +     +P   T       E  D T+               L ++SL SS 
Sbjct: 1138 SGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTV---------DRQKSSLSNNSLKSS- 1187

Query: 880  FLDGMNYLRYSLEGGRSDSLRSFSS---------DRSHTLSHASYLRDSAV----MDDSV 926
                           ++ SLR+ SS         D  H LS    ++  ++       S+
Sbjct: 1188 ---------------KNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSI 1232

Query: 927  VIPSHQVSTLAKEAERNSYRLSW 949
            V PS    +L +     S    W
Sbjct: 1233 VSPSSTTQSLGQSHNSPSSEFEW 1255



 Score =  291 bits (746), Expect = 7e-78
 Identities = 211/693 (30%), Positives = 338/693 (48%), Gaps = 50/693 (7%)

Query: 109  QAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
            + EV+++LVK GA++N++       +  A +    D ++ LL+NGA+ +    +G T LA
Sbjct: 493  EQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLA 550

Query: 169  VALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 228
             A   G    V +L+                     ++ A L +++ H            
Sbjct: 551  NAAYSGSLDVVNLLV---------------------SRGADLEIEDAH------------ 577

Query: 229  TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
                G TPL +AA  G+  V   L+  GA ++ T ++G T L  A+  G+T +V  LL  
Sbjct: 578  ----GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633

Query: 289  GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
            G ++D    D  T L  AA  GH+ +V  LL+ GA +      G + L  AA   H E V
Sbjct: 634  GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIV 693

Query: 349  KHLLQHKAPVDDVTLDYLTALHVAAHC-----GHYRVTKLLLDKRANPNARALNGFTPLH 403
            +HLL H A V+   +D  TAL VAA C     GH  V  LL+D+ A  +    +G TPL 
Sbjct: 694  EHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL 753

Query: 404  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463
            +A  +  + V++LL++ GA +     +G TP+  AA MGH ++V  LL  GA+ D  +  
Sbjct: 754  VAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 813

Query: 464  GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
            G T L +A+  G VEVVR LL  G   + R     TPLH+A+  G   I + L++  A  
Sbjct: 814  GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART 873

Query: 524  DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
            +    +G  P  ++++EG  D   +LLE  +        G   L VAA  G  D+ +LL 
Sbjct: 874  NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933

Query: 584  QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
               A  +    +G   L++ A  +   +A   LE GA+  A+   G T LH++  +  M+
Sbjct: 934  SHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHME 993

Query: 644  IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 703
            +   L+ Y A+ N    +  + L  A+ +GH  +V LL++ GA +  +   G T+L +AA
Sbjct: 994  MVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAA 1053

Query: 704  QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY- 762
            QE  ++V  +L +HGAD +   + G T + VA   G+ +++  L K GA+    + NG  
Sbjct: 1054 QEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS----SLNGCS 1109

Query: 763  -TPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
             +P+H   Q+    + + +     K N++ + G
Sbjct: 1110 PSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142



 Score =  281 bits (720), Expect = 7e-75
 Identities = 195/583 (33%), Positives = 301/583 (51%), Gaps = 21/583 (3%)

Query: 30   DSNASFL--RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
            DSN   L   AA +G+LD V   +  G D+   + +G   L LAA++GH  +V  L+G G
Sbjct: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601

Query: 88   SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
            ++++   + G TAL  A+  G  EVV  L+  G  ++    +  T L  AA   H D+V 
Sbjct: 602  ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661

Query: 148  YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRL--PALHI 198
             LL++GA  + A  +G T L  A   GH + V  LL++       D  G+  L   AL +
Sbjct: 662  NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721

Query: 199  AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258
             A K      +LL+  D  A+      V+   + G TPL +AA+ G+V+V  LLL  GA 
Sbjct: 722  PASKGHASVVSLLI--DRGAE------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773

Query: 259  VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
            VD T  NG TPL  A+  G+ ++V  LL  G  +D+   +G T L  A+  G+ +VV  L
Sbjct: 774  VDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833

Query: 319  LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
            L+RG     R   G +PLHMAA   H    + L++  A  +++  D      +A+  GHY
Sbjct: 834  LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHY 893

Query: 379  RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
               ++LL+ ++N + R  +G   L +A  +    ++ELL  +GA +      G   +++ 
Sbjct: 894  DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953

Query: 439  AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498
            A    L +    L+NGA+ + ++  G TALH++   G +E+V+ L+   A V+A   E++
Sbjct: 954  ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013

Query: 499  TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558
            + L  A+  G  ++VQLL++H A  D     G T L I+A+EG +DV  VLLE GA  + 
Sbjct: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073

Query: 559  ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
            A + G T + VAAK G   + KLL   +  A S      +P+H
Sbjct: 1074 ADQFGRTAMRVAAKNGHSQIIKLL--EKYGASSLNGCSPSPVH 1114



 Score =  270 bits (689), Expect = 3e-71
 Identities = 208/715 (29%), Positives = 328/715 (45%), Gaps = 42/715 (5%)

Query: 252  LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
            LL+ GA+V+    NG T L  A+  G+ ++V LL+ RG  ++ +   G TPL  AAR GH
Sbjct: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590

Query: 312  DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371
             +VV  L+  GA +    ++G + L  AA G H E V  LL     VD    D  TAL  
Sbjct: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650

Query: 372  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
            AA  GH  +               LN                   L+++GA +      G
Sbjct: 651  AAWGGHEDIV--------------LN-------------------LLQHGAEVNKADNEG 677

Query: 432  LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA-----ARAGQVEVVRCLLRN 486
             T +  AA+MGH  IV  LL +GA  +  ++ G TAL +A     A  G   VV  L+  
Sbjct: 678  RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737

Query: 487  GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
            GA VD   ++  TPL +A+  G  ++V LLL+  A  D    NG TPL  +A  G   V 
Sbjct: 738  GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797

Query: 547  SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606
            + LL  GAA      +G T L +A+  G+++V + LL R    +     G TPLH+AA  
Sbjct: 798  NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857

Query: 607  DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
             ++ +   L+E+GA  +    +G  P  +A+++        LL   +  +     G   L
Sbjct: 858  GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNAL 917

Query: 667  HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
             +A+ EGH D+V LL   GA+++     G  +L++ A E+++ +A+   ++GA+ +A   
Sbjct: 918  RVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 977

Query: 727  LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
             G T L V+C  G+++MV  L+   A+VNA      + L  AA QGH  ++ +L++HGA 
Sbjct: 978  EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037

Query: 787  PNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVS 846
             + T   G TAL IA + G+I VV  L     +            ++      ++++ + 
Sbjct: 1038 VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097

Query: 847  DEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDR 906
            ++ G  ++ G     +   + K L   S          N    +  G    SLR   +  
Sbjct: 1098 EKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGP 1157

Query: 907  SHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSS 961
            +H  S  S   DS V      + ++ +    K ++ +S R +  T     V + S
Sbjct: 1158 THAFSSPSESPDSTVDRQKSSLSNNSL----KSSKNSSLRTTSSTATAQTVPIDS 1208



 Score =  202 bits (514), Expect = 5e-51
 Identities = 150/473 (31%), Positives = 228/473 (48%), Gaps = 56/473 (11%)

Query: 29   SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
            +DS  +   AA  G+ D V+  L+ G ++N  +  G  AL  AA  GH  +V+ LL  G+
Sbjct: 642  ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701

Query: 89   SVDSATKKGNTALHIASLA-----GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
             V+     G TAL +A+L      G A VV +L+  GA ++   ++G TPL +AA E H+
Sbjct: 702  EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761

Query: 144  DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL-------ENDTKGKVRLPAL 196
            DVV  LLE GA+      +G TPL  A   GH   V  LL         D++G+     L
Sbjct: 762  DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT---VL 818

Query: 197  HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
             IA+ + + +    LL  D   D       N   ++G+TPLH+AA  G+  +   L+ +G
Sbjct: 819  SIASAQGNVEVVRTLL--DRGLDE------NHRDDAGWTPLHMAAFEGHRLICEALIEQG 870

Query: 257  AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 316
            A  +    +G  P  +AS+ G+ + V++LL+    ID +  DG   L  AA  GH  +VE
Sbjct: 871  ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930

Query: 317  LL---------------------------------LERGAPLLARTKNGLSPLHMAAQGD 343
            LL                                 LE GA + A    G + LH++    
Sbjct: 931  LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990

Query: 344  HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
            H+E V+ L+ + A V+    +  +AL  AA  GH +V +LL++  A  +     G T L 
Sbjct: 991  HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALC 1050

Query: 404  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
            IA ++  I V+++L+++GA      + G T + VAA  GH  I+ LL + GAS
Sbjct: 1051 IAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103



 Score =  191 bits (486), Expect = 9e-48
 Identities = 140/404 (34%), Positives = 201/404 (49%), Gaps = 22/404 (5%)

Query: 30   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
            D     L AA  G++D V   L+GG D++  + NG   L  AA  GH  +V  LL  G++
Sbjct: 747  DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806

Query: 90   VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
            VDS   +G T L IAS  G  EVV+ L+  G + N +   G+TPL+MAA E H  + + L
Sbjct: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866

Query: 150  LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDT 205
            +E GA  +    DG  P  +A Q+GH   V ILLEN    D +G     AL +AA +   
Sbjct: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926

Query: 206  KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
                LL    H ADV  K    R T      L+I A    + +A   L  GA V+ +   
Sbjct: 927  DIVELLF--SHGADVNCKDADGRPT------LYILALENQLTMAEYFLENGANVEASDAE 978

Query: 266  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
            G T LHV+  +G+  MV++L+     ++A   +  + L  AA  GH +VV+LL+E GA +
Sbjct: 979  GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038

Query: 326  LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385
                  G + L +AAQ  H++ V+ LL+H A  +       TA+ VAA  GH ++ KLL 
Sbjct: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL- 1097

Query: 386  DKRANPNARALNGFTPLHIACKKNR------IKVMELLVKYGAS 423
                   A +LNG +P  +   + +       KV  L +K  +S
Sbjct: 1098 ---EKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138



 Score =  107 bits (268), Expect = 2e-22
 Identities = 81/242 (33%), Positives = 116/242 (47%), Gaps = 7/242 (2%)

Query: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
           +V +LL++  A  +S  ++  T   V    + +     LL+ GAS +    NG T L  A
Sbjct: 495 EVLQLLVKAGAHVNS--EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696
           A    + + + L++ GA+  I    G TPL LA+++GHT +V  L+  GANI+ + + G 
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756
           T+L  AA      V   L   G   D       T L  A   G+  +V  LL+ GA VN 
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 757 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA-----KRLGYISVVD 811
               G T L  AA  GH  I+  LL HGA+ N    +G TAL++A        G+ SVV 
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 812 TL 813
            L
Sbjct: 733 LL 734



 Score = 96.7 bits (239), Expect = 4e-19
 Identities = 52/156 (33%), Positives = 89/156 (57%)

Query: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
            K +D   +    A    L     +L+ G ++   +  G  ALH++  +GH+ +VQ L+  
Sbjct: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001

Query: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
             + V++A  +  +AL  A+  G  +VV++L++ GA ++     G T L +AAQE HIDVV
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061

Query: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
            + LLE+GA+ + A + G T + VA + GH+Q + +L
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  305 bits (782), Expect = 4e-82
 Identities = 254/850 (29%), Positives = 376/850 (44%), Gaps = 70/850 (8%)

Query: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
           RA  + + + V   +K   D+N  ++N    LH+AA    V   + ++   SSV+ + + 
Sbjct: 55  RAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114

Query: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
           G TALH A+L G  E+V +L+ +GANINA  +     L+ AA   H+DVV  L+ +GA  
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174

Query: 157 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 212
           +   + G+TPL  A   G    V  LL    E D        ALHIA           L+
Sbjct: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234

Query: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 271
             D+ A+      VN+   +GFTPLH AA   +  +   LL+N GA V+  +++G +PLH
Sbjct: 235 --DYGAN------VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286

Query: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
           + +  G     + L+  GG+ID   +DG TPLH AAR GH+ ++  L   GA       +
Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH 346

Query: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
            + PLH+AA   H +C + LL     +D       T LH AA  G+    KLL    A+ 
Sbjct: 347 SMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 406

Query: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA---------FMG 442
           + +   G TPLH A        +E LV  GA++    + G T +H AA          +G
Sbjct: 407 HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILG 466

Query: 443 HLN-------------------IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
           + +                    +  LLQN A+P + +  G  ++H AA  G  + +  L
Sbjct: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526

Query: 484 LR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
           L   N    ++ +   ++PLH+A+  G  + +++LLQ +   D     G T L ++A +G
Sbjct: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586

Query: 542 QVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQ---RRAAADSAGKN 595
             +    L+  GA+       TK+  TPLH +   G     +LLL+      A D     
Sbjct: 587 HTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644

Query: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
           G TPL +A  Y +     LLLEK A+       G T LH        +    LL      
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI 704

Query: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVAD 712
                +G TPLH A+  GH   ++ LL    +          G T LH A      N  +
Sbjct: 705 LCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIE 764

Query: 713 ILTKHGADQDAHTKL---GYTPLIVAC--HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
           +L     +Q    K     +TPL  A    +GN   +       + V+ +   G TPL  
Sbjct: 765 VL----LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820

Query: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTI 827
           AA   H   + +LL+H A  NA   +G TAL +A   G    VD L      V +    +
Sbjct: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL------VNSAQADL 874

Query: 828 TEKHK-LNVP 836
           T K K LN P
Sbjct: 875 TVKDKDLNTP 884



 Score =  294 bits (752), Expect = 1e-78
 Identities = 234/777 (30%), Positives = 344/777 (44%), Gaps = 79/777 (10%)

Query: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
           AA  G+LD V   +  G ++   ++ G   LH AA  G + +V+ LL  G  +D     G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214

Query: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLENGANQ 156
           NTALHIA   GQ  VV  L+  GAN+N  + NGFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274

Query: 157 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216
           +  ++DG +PL                         + A+H    +  T     L+QN  
Sbjct: 275 NIQSKDGKSPL------------------------HMTAVHGRFTRSQT-----LIQNGG 305

Query: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
             D   K         G TPLH+AA YG+  +   L   GA       + + PLH+A+  
Sbjct: 306 EIDCVDK--------DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN 357

Query: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
            +++  + LL  G +ID   + G T LH AA  G+ + ++LL   GA    + K G +PL
Sbjct: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417

Query: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR----------------- 379
           H AA   H  C++ L+   A V++      TALH AA     R                 
Sbjct: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477

Query: 380 -----------VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
                        + LL   ANP+ R   G+  +H A      + +ELL++   S    +
Sbjct: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537

Query: 429 ESGLT--PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
           +SG T  P+H+AA+ GH   + +LLQ+    D+ + +G TAL +AA  G  E V  L+  
Sbjct: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597

Query: 487 GALVDARAR-EEQTPLHIASRLGKTEIVQLLLQHMAHPDAA---TTNGYTPLHISAREGQ 542
           GA +  +    ++TPLH +   G T  ++LLL+   +P+A       G TPL ++   G 
Sbjct: 598 GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657

Query: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
           +D  S+LLE  A        G T LH     G  +  ++LL++  +       G TPLH 
Sbjct: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717

Query: 603 AAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659
           AA   +      LL+   S          GYTPLH A           LL        + 
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777

Query: 660 KQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
               TPLH A    H +  +LLL     + +      G T L  AA  D V    +L +H
Sbjct: 778 NP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836

Query: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGH 773
            A  +A    G T L++A   G    V+ L+    A++  K K+  TPLH A  +GH
Sbjct: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893



 Score =  254 bits (650), Expect = 9e-67
 Identities = 183/577 (31%), Positives = 277/577 (48%), Gaps = 31/577 (5%)

Query: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
           TPLHVA+  G+  +++LL+  G +++AK    LTPLH A  S  ++ V++L++  A + A
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
           R KN  +PLH+AA    V+C + ++   + V+       TALH AA  GH  +  LLL K
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 447
            AN NA        LH A     + V+ LL+ +GA +    + G TP+H AA  G +N+V
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197

Query: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
             LL  G   D  N+ G TALH+A   GQ  VV  L+  GA V+       TPLH A+  
Sbjct: 198 KHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAS 257

Query: 508 GKTEI-VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
               + ++LL+ + A  +  + +G +PLH++A  G+   +  L++ G       K G TP
Sbjct: 258 THGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTP 317

Query: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
           LHVAA+YG   +   L    A     G + + PLH+AA   +      LL  G       
Sbjct: 318 LHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPD 377

Query: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
           K G T LH AA    ++    L + GA+ +   K G TPLH A+   H   +  L+  GA
Sbjct: 378 KFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA 437

Query: 687 NIHMSTKSGLTSLHLAA----------------------------QEDKVNVADILTKHG 718
           N++ +   G T+LH AA                            +++     + L ++ 
Sbjct: 438 NVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND 497

Query: 719 ADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT--PLHQAAQQGHTHI 776
           A+     K GY  +  A  YG+ + +  LL++  +   ++ +G T  PLH AA  GH   
Sbjct: 498 ANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQA 557

Query: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           + VLLQ     +     G TAL +A   G+   V+ L
Sbjct: 558 LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594



 Score =  250 bits (639), Expect = 2e-65
 Identities = 200/664 (30%), Positives = 293/664 (44%), Gaps = 44/664 (6%)

Query: 185 NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244
           N    + R P LH+AA   D +   LL+ +    + +  M +        TPLH A    
Sbjct: 10  NTLDSEKRTP-LHVAAFLGDAEIIELLILSGARVNAKDNMWL--------TPLHRAVASR 60

Query: 245 NVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304
           +     +L+   A V+   +N  TPLHVA+        ++++     ++   R G T LH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
            AA +GH ++V LLL +GA + A  K     LH AA   H++ V  L+ H A V      
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 365 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424
             T LH AA  G   V K LL+     +   + G T LHIAC   +  V+  L+ YGA++
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 425 QAITESGLTPIHVAAFMGHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
                +G TP+H AA   H  + L LL+ NGA  ++ +  G++ LHM A  G+    + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
           ++NG  +D   ++  TPLH+A+R G   ++  L    A       +   PLH++A     
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
           D    LL +G       K G T LH AA  G+++  KLL    A      K G TPLH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420

Query: 604 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA-------------------------- 637
           A   +      L+  GA+ + T   G T LH AA                          
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480

Query: 638 --KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
             +K        LL   A  +I  K+G   +H A+  GH   + LLL++  +    + SG
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540

Query: 696 LTS--LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
            T   LHLAA        ++L +   D D   + G T L +A   G+ + V  L+  GA+
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600

Query: 754 VNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPNAT---TANGNTALAIAKRLGYISV 809
           +  K      TPLH +   GHT  + +LL+    P A     A G T L +A   G+I  
Sbjct: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660

Query: 810 VDTL 813
           V  L
Sbjct: 661 VSLL 664



 Score =  239 bits (610), Expect = 4e-62
 Identities = 163/528 (30%), Positives = 252/528 (47%), Gaps = 29/528 (5%)

Query: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
           +L+ +   ++    +  TPLH AA  G  +++ELL+  GA + A+    L+PLH A    
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
             E V+ L++H A V+    ++ T LHVAA     +  ++++   ++ N     G T LH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463
            A     ++++ LL+  GA+I A  +     +H AA+MGHL++V LL+ +GA     + +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
           G T LH AA  GQ+ VV+ LL  G  +D       T LHIA   G+  +V  L+ + A+ 
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 524 DAATTNGYTPLHISAREGQVDVA-SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
           +    NG+TPLH +A      +   +L+  GA  ++ +K G +PLH+ A +G    ++ L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
           +Q     D   K+G TPLHVAA Y ++ +   L   GA       +   PLH+AA     
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702
                LL+ G E +   K G T LH A+  G+ + + LL   GA+ H   K G T LH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420

Query: 703 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH---------YGNVK----------- 742
           A     +  + L   GA+ +     G T L  A            GN             
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480

Query: 743 --------MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
                    + FLL+  AN + + K GY  +H AA  GH   + +LL+
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528



 Score =  206 bits (523), Expect = 5e-52
 Identities = 171/602 (28%), Positives = 255/602 (42%), Gaps = 57/602 (9%)

Query: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
           D N     AAR G+   +      G D   C  + +  LHLAA   H    ++LL  G  
Sbjct: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372

Query: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
           +D+  K G T LH A+  G  E +K+L   GA+ + + + G TPL+ AA   H   ++ L
Sbjct: 373 IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432

Query: 150 LENGANQSTATEDGFTPL--AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKS 207
           +  GAN +   + G T L  A A     N+ +   L N       L        K+ T  
Sbjct: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTI---LGNAHDNSEELERARELKEKEATLC 489

Query: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
              LLQND N  ++ K         G+  +H AA YG+     LLL R  +    + +G 
Sbjct: 490 LEFLLQNDANPSIRDK--------EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541

Query: 268 T--PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
           T  PLH+A+  G+   +++LL     +D +   G T L  AA  GH + VE L+  GA +
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601

Query: 326 LARTK-NGLSPLHMAAQGDHVECVKHLLQ---HKAPVDDVTLDYLTALHVAAHCGHYRVT 381
             +      +PLH +    H  C++ LL+   +   VD       T L +A   GH    
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661

Query: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
            LLL+K AN +   + G T LH        + +++L++   SI      G TP+H AA  
Sbjct: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721

Query: 442 GHLNIVLLLLQNGASPD---VTNIRGETALHMAARAGQVEVVRCLLR------------- 485
           GH   +  LLQ   S +     + +G T LH A   G    +  LL              
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT 781

Query: 486 ---------------------NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
                                + ++V  R  + +TPL  A+     E +QLLL+H A  +
Sbjct: 782 PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841

Query: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TPLHVAAKYGSLDVAKLLL 583
           A   +G T L ++A  GQ     +L+ +  A      K   TPLH+A   G    A L+L
Sbjct: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901

Query: 584 QR 585
            +
Sbjct: 902 DK 903



 Score =  189 bits (481), Expect = 4e-47
 Identities = 116/331 (35%), Positives = 173/331 (52%), Gaps = 3/331 (0%)

Query: 458 DVTNIRGE--TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
           DV  +  E  T LH+AA  G  E++  L+ +GA V+A+     TPLH A      E VQ+
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67

Query: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
           L++H A  +A   N  TPLH++A    V  A V++   ++ +++ + G T LH AA  G 
Sbjct: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127

Query: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635
           +++  LLL + A  ++  K     LH AA+  +  V  LL+  GA      K GYTPLH 
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187

Query: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
           AA   Q+ +   LLN G E + +   G T LH+A   G   +V  L+D GAN++    +G
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247

Query: 696 LTSLHLAAQEDKVNVA-DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
            T LH AA      +  ++L  +GAD +  +K G +PL +   +G       L++ G  +
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307

Query: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGA 785
           +   K+G TPLH AA+ GH  +IN L   GA
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGA 338



 Score = 92.0 bits (227), Expect = 1e-17
 Identities = 58/174 (33%), Positives = 84/174 (48%)

Query: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707
           L++   + N +  +  TPLH+A+  G  +++ LL+  GA ++      LT LH A     
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 708 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
                +L KH AD +A  K   TPL VA     VK    ++   ++VN   + G T LH 
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121

Query: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821
           AA  GH  ++N+LL  GA  NA       AL  A  +G++ VV  L     EVT
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  296 bits (759), Expect = 2e-79
 Identities = 257/815 (31%), Positives = 370/815 (45%), Gaps = 104/815 (12%)

Query: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSATK 95
           A R G++++V + L     +N+ +  G  +  LH AA  G   +V+ LL  G++V +   
Sbjct: 31  ACRNGDVERV-KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89

Query: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
            G   LH A   G AEVV +L++ GA+ NA+    +TPL+ AA +  IDV   LL++GA 
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ-- 213
            +    DG T L +A       A A+L     K ++    L  A   ++ K  ALL    
Sbjct: 150 PTIRNTDGRTALDLA----DPSAKAVLTGEYKKDEL----LESARSGNEEKMMALLTPLN 201

Query: 214 -NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 272
            N H +D +             TPLH+AA Y  V +  LLL  GA V    +  + PLH 
Sbjct: 202 VNCHASDGRKS-----------TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250

Query: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 331
           A   G+  + +LL+  G  ++A      TPLH AA     +V  LLL  GA P L    N
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310

Query: 332 ---------------------GLSPLHMAAQGDHVECVKHL----LQHKAPVDDVTLDYL 366
                                G S L  A + D     KHL    +  K P       + 
Sbjct: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQT-----HE 365

Query: 367 TALHVAAHCGHYR---VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
           TALH AA   + +   + +LLL K AN N +     TPLH+A +K    V+E++VK+ A 
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425

Query: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM------------- 470
           + A+   G T +H AA+ GHL    LLL  G  P++ +++G TAL M             
Sbjct: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGI 485

Query: 471 -------------AARAGQVEVVR--CLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
                        AA+AG VE V+  C +++    D   R+  TPLH A+   +  +V+ 
Sbjct: 486 SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQS-TPLHFAAGYNRVSVVEY 544

Query: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
           LLQH A   A    G  PLH +   G  +VA +L++ GA  ++A    FTPLH AA  G 
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604

Query: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635
            ++ KLLLQ  A      ++G TPL +    D     LL              G   L  
Sbjct: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLL-------------RGDAALLD 651

Query: 636 AAKKNQMQIASTLLNYGAETNIVTKQG--VTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
           AAKK  +     L +     N    QG   TPLHLA+   + ++   LL  GA+++   K
Sbjct: 652 AAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDK 710

Query: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
            GL  LH AA    V+VA +L K+ A  +A  K  +TPL  A   G  ++   LL  GA+
Sbjct: 711 GGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 770

Query: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
              K + G TPL   +    + ++   +   A P+
Sbjct: 771 PTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS 805



 Score =  278 bits (711), Expect = 8e-74
 Identities = 237/745 (31%), Positives = 324/745 (43%), Gaps = 147/745 (19%)

Query: 186 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
           DT G+   P LH AA          LLQN   A+VQ++       + G  PLH A  +G+
Sbjct: 53  DTAGRKSTP-LHFAAGFGRKDVVEYLLQN--GANVQAR------DDGGLIPLHNACSFGH 103

Query: 246 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
             V  LLL  GA  +       TPLH A+ +G  ++  +LL  G +   +  DG T L  
Sbjct: 104 AEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDL 163

Query: 306 A--------------------ARSGHDQ-VVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
           A                    ARSG+++ ++ LL        A      +PLH+AA  + 
Sbjct: 164 ADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNR 223

Query: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
           V+ V+ LLQH A V       L  LH A   GHY VT+LL+   A  NA  L  FTPLH 
Sbjct: 224 VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHE 283

Query: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA-----------FMGHLNIVLLLLQN 453
           A  KNR++V  LL+ YGA    +     + I +A            F GH      LLQ 
Sbjct: 284 AASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS-----LLQA 338

Query: 454 GASPDVTNIRG---------------ETALHMAARAG---QVEVVRCLLRNGALVDARAR 495
               DVT I+                ETALH AA +    + ++   LLR GA ++ + +
Sbjct: 339 AREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTK 398

Query: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL------ 549
           E  TPLH+AS     ++V+++++H A  +A    G T LH +A  G +    +L      
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCD 458

Query: 550 --------------------------------------LEAGAAHSLATKKGF------- 564
                                                 LEA  A  + T K         
Sbjct: 459 PNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVN 518

Query: 565 ---------TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
                    TPLH AA Y  + V + LLQ  A   +  K GL PLH A  Y + +VA LL
Sbjct: 519 CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578

Query: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
           ++ GA  +      +TPLH AA K + +I   LL +GA+     + G TPL L  ++G T
Sbjct: 579 VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDT 637

Query: 676 DMVTLLLDKGANIHMSTKSGL----------------------TSLHLAAQEDKVNVADI 713
           D+  LL    A +  + K  L                      T LHLAA  + + VA+ 
Sbjct: 638 DIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEY 697

Query: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
           L +HGAD +A  K G  PL  A  YG+V +   L+K  A VNA  K  +TPLH+AAQ+G 
Sbjct: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757

Query: 774 THIINVLLQHGAKPNATTANGNTAL 798
           T +  +LL HGA P      G T L
Sbjct: 758 TQLCALLLAHGADPTLKNQEGQTPL 782



 Score =  228 bits (582), Expect = 7e-59
 Identities = 189/599 (31%), Positives = 266/599 (44%), Gaps = 77/599 (12%)

Query: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
           TA    TPLH A+  G  ++V+ LL  G  + A+   GL PLH A   GH +VV LLL  
Sbjct: 54  TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113

Query: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA------AHC 375
           GA   AR     +PLH AA    ++    LLQH A       D  TAL +A         
Sbjct: 114 GADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLT 173

Query: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
           G Y+  +LL   R+    + +   TPL++ C                   A      TP+
Sbjct: 174 GEYKKDELLESARSGNEEKMMALLTPLNVNC------------------HASDGRKSTPL 215

Query: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 495
           H+AA    + IV LLLQ+GA     +      LH A   G  EV   L+++GA V+A   
Sbjct: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275

Query: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHP-----------DAATT-----------NGYTP 533
            + TPLH A+   + E+  LLL + A P           D A T            G++ 
Sbjct: 276 WQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSL 335

Query: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG---SLDVAKLLLQRRAAAD 590
           L  +ARE  V      L     +    +   T LH AA         + +LLL++ A  +
Sbjct: 336 LQ-AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANIN 394

Query: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
              K  LTPLHVA+   +  V  ++++  A  +A    G T LH AA    +Q    LL+
Sbjct: 395 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454

Query: 651 YGAETNIVTKQGVTPLHLASQE-----------GHTDMVTLLLDKGANIHMSTKSGL--- 696
           YG + NI++ QG T L + ++            G+++    LL+      + T   L   
Sbjct: 455 YGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTV 514

Query: 697 -------------TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
                        T LH AA  ++V+V + L +HGAD  A  K G  PL  AC YG+ ++
Sbjct: 515 QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEV 574

Query: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
              L+K GA VN      +TPLH+AA +G   I  +LLQHGA P     +GNT L + K
Sbjct: 575 AELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633



 Score =  226 bits (577), Expect = 3e-58
 Identities = 212/725 (29%), Positives = 314/725 (43%), Gaps = 101/725 (13%)

Query: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 93
           L +AR+GN +K++  L   +++N    +G  +  LHLAA    V +VQ LL  G+ V + 
Sbjct: 182 LESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240

Query: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
            K     LH A   G  EV ++LVK GA +NA     FTPL+ AA +N ++V   LL  G
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
           A+ +             L   HN++   L           P   +  R         LLQ
Sbjct: 301 ADPT-------------LLNCHNKSAIDLA----------PTPQLKERLAYEFKGHSLLQ 337

Query: 214 NDHNADVQ------SKMMVN-RTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTA 263
               ADV       S  MVN +  ++  T LH AA   +     +  LLL +GA ++   
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397

Query: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
           +  +TPLHVAS++ + ++V++++    +++A    G T LH AA  GH Q   LLL  G 
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457

Query: 324 PLLARTKNGLSPLHM--------------------------AAQGDHVECVKHLLQ-HKA 356
                +  G + L M                          AA+   VE VK L      
Sbjct: 458 DPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSV 517

Query: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 416
              D+     T LH AA      V + LL   A+ +A+   G  PLH AC     +V EL
Sbjct: 518 NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAEL 577

Query: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
           LVK+GA +        TP+H AA  G   I  LLLQ+GA P   N  G T L +  + G 
Sbjct: 578 LVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGD 636

Query: 477 VEVVRCLLRNGALVDARAR----------------------EEQTPLHIASRLGKTEIVQ 514
            ++   L  + AL+DA  +                         TPLH+A+     E+ +
Sbjct: 637 TDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696

Query: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
            LLQH A  +A    G  PLH +A  G VDVA++L++  A  +   K  FTPLH AA+ G
Sbjct: 697 YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKG 756

Query: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634
              +  LLL   A      + G TPL + +  D   V+ LL    A P +   + Y P  
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPLDLVSADD---VSALL--TAAMPPSALPSCYKP-- 809

Query: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
                   Q+ + + + GA  + ++    +P  L++     ++     +  + +  S   
Sbjct: 810 --------QVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTE 861

Query: 695 GLTSL 699
           G +SL
Sbjct: 862 GASSL 866



 Score =  171 bits (433), Expect = 1e-41
 Identities = 139/449 (30%), Positives = 203/449 (45%), Gaps = 72/449 (16%)

Query: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
           R  T LH AA  G+ +VV  LL+NGA V AR      PLH A   G  E+V LLL+H A 
Sbjct: 57  RKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGAD 116

Query: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
           P+A     YTPLH +A +G++DV  VLL+ GA  ++    G T L +A        AK +
Sbjct: 117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS-----AKAV 171

Query: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
           L      D         L  A   + +K+  LL     + HA+     TPLH+AA  N++
Sbjct: 172 LTGEYKKDEL-------LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 224

Query: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702
           +I   LL +GA+ +   K  + PLH A   GH ++  LL+  GA ++       T LH A
Sbjct: 225 KIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA 284

Query: 703 AQEDKVNVADILTKHGADQ---DAHTK----LGYTP--------------LIVACHYGNV 741
           A +++V V  +L  +GAD    + H K    L  TP              L+ A    +V
Sbjct: 285 ASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADV 344

Query: 742 ---------KMVNF---------------------------LLKQGANVNAKTKNGYTPL 765
                    +MVNF                           LL++GAN+N KTK   TPL
Sbjct: 345 TRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPL 404

Query: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVV---TEEVTT 822
           H A+++ H  ++ V+++H AK NA    G T+L  A   G++     L         ++ 
Sbjct: 405 HVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL 464

Query: 823 TTTTITEKHKLNVPETMTEVLDVSDEEGD 851
              T  +    NV + + E + + + E D
Sbjct: 465 QGFTALQMGNENVQQLLQEGISLGNSEAD 493



 Score =  150 bits (378), Expect = 3e-35
 Identities = 99/287 (34%), Positives = 140/287 (48%), Gaps = 22/287 (7%)

Query: 537 SAREGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595
           + R G V+    L+     +S  T  +  TPLH AA +G  DV + LLQ  A   +    
Sbjct: 31  ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90

Query: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
           GL PLH A  + + +V  LLL  GA P+A     YTPLH AA K ++ +   LL +GAE 
Sbjct: 91  GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150

Query: 656 NIVTKQGVTPLHLA--------------------SQEGHTD-MVTLLLDKGANIHMSTKS 694
            I    G T L LA                    ++ G+ + M+ LL     N H S   
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210

Query: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
             T LHLAA  ++V +  +L +HGAD  A  K    PL  AC YG+ ++   L+K GA V
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270

Query: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
           NA     +TPLH+AA +    + ++LL +GA P     +  +A+ +A
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317



 Score =  136 bits (343), Expect = 4e-31
 Identities = 97/316 (30%), Positives = 153/316 (48%), Gaps = 17/316 (5%)

Query: 29  SDSNASFLRAARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
           S+++   L AA+AG+++ V +      ++           LH AA    V +V+ LL  G
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549

Query: 88  SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
           + V +  K G   LH A   G  EV ++LVK GA +N      FTPL+ AA +   ++ K
Sbjct: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICK 609

Query: 148 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKS 207
            LL++GA+ +    DG TPL + ++ G         + D +  +R  A  + A K    +
Sbjct: 610 LLLQHGADPTKKNRDGNTPLDL-VKDG---------DTDIQDLLRGDAALLDAAKKGCLA 659

Query: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
               L +  N + +       T     TPLH+AA Y N+ VA  LL  GA V+   + G+
Sbjct: 660 RVKKLSSPDNVNCRD------TQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713

Query: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
            PLH A+  G+ ++  LL+     ++A  +   TPLH AA+ G  Q+  LLL  GA    
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773

Query: 328 RTKNGLSPLHMAAQGD 343
           + + G +PL + +  D
Sbjct: 774 KNQEGQTPLDLVSADD 789



 Score = 95.5 bits (236), Expect = 9e-19
 Identities = 75/257 (29%), Positives = 104/257 (40%), Gaps = 54/257 (21%)

Query: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
           AAA++             + D ++V  L+  +  +   TA    TPLH AA   +  +  
Sbjct: 16  AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVE 75

Query: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
            LL  GA        G+ PLH A   GH ++V LLL  GA+ +       T LH AA + 
Sbjct: 76  YLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135

Query: 707 KVNVADILTKHGAD-----QDAHTKLG--------------------------------- 728
           K++V  +L +HGA+      D  T L                                  
Sbjct: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMA 195

Query: 729 -YTPLIVACH---------------YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 772
             TPL V CH               Y  VK+V  LL+ GA+V+AK K    PLH A   G
Sbjct: 196 LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255

Query: 773 HTHIINVLLQHGAKPNA 789
           H  +  +L++HGA  NA
Sbjct: 256 HYEVTELLVKHGACVNA 272



 Score = 66.2 bits (160), Expect = 6e-10
 Identities = 48/139 (34%), Positives = 62/139 (44%), Gaps = 15/139 (10%)

Query: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
           TPL  A  +G   +V +LL+ GANV A+   G  PLH A   GH  ++N+LL+HGA PNA
Sbjct: 60  TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119

Query: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 849
                 T L  A   G I V   L     E T   T                 LD++D  
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT------------DGRTALDLADPS 167

Query: 850 GDDTMTGDGGEYLRPEDLK 868
               +T   GEY + E L+
Sbjct: 168 AKAVLT---GEYKKDELLE 183


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  293 bits (751), Expect = 2e-78
 Identities = 262/848 (30%), Positives = 378/848 (44%), Gaps = 86/848 (10%)

Query: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
           A  +G+L+ V   L  G  +N C++     LH AA  GH+ +++ L+ RG+ +    +KG
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206

Query: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
              LH A+ +GQ EVVK L++ GA I+  +  G T L++A       V   L+  GAN +
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266

Query: 158 TATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIAARKDDTKSAALLL 212
              + GFTPL VA    +      LL N     + + K     LH+AA       + +L+
Sbjct: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326

Query: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI---TP 269
           QN    D   K         G TPLH+AA YG+  + + L+  GA    TAR GI    P
Sbjct: 327 QNGSEIDCADKF--------GNTPLHVAARYGHELLISTLMTNGAD---TARRGIHDMFP 375

Query: 270 LHVASKRGNTNMVKLLLDRG----------------GQIDAKTRD--GLTPLHCAARSGH 311
           LH+A   G ++  + LL  G                   D  T D  G T LH AA  G+
Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435

Query: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371
            + + LLL  GA L  R K G +PLH AA     +C   L+   A V++      + LH 
Sbjct: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 495

Query: 372 AAHCGHYR----------------------------VTKLLLDKRANPNARALNGFTPLH 403
           AA    YR                              + LLD  A+P+ R   G+T +H
Sbjct: 496 AAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555

Query: 404 IACKKNRIKVMELLVKYGASIQAITESGL--TPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
            A      + +ELL++   +     ES +  +P+H+AA+ GH   +  L +   + DV +
Sbjct: 556 YAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615

Query: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLL--- 517
            +G TAL +A   G  E V  L  +GA    + R+ + TPLH A+  G T+ + LL+   
Sbjct: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675

Query: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
           +     D     G TPL ++   G VD   +LLE G+    A  +G T LH  A  G  D
Sbjct: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735

Query: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH----ATAKNGYTPL 633
               LL   A        G TP+H+A+   +  V   LL+   S          +GY+P+
Sbjct: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795

Query: 634 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA---SQEGHTDMVTLLLDKGANIHM 690
           H A+          LL + +  + +     TPLH A   +Q+  T+M  LL   GA I  
Sbjct: 796 HWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM--LLGALGAKIVN 852

Query: 691 STKS-GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
           S  + G T LH AA  D V+   +L +H A+ +A    G T L+ A   G    V FLL 
Sbjct: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912

Query: 750 QG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLL---QHGAKPNATTANGNTALAIAKRLG 805
           +G A++    +N  T LH A  +GH     ++L   Q     NAT +     L IA R G
Sbjct: 913 RGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972

Query: 806 YISVVDTL 813
             SVV  L
Sbjct: 973 LASVVQAL 980



 Score =  283 bits (725), Expect = 2e-75
 Identities = 250/840 (29%), Positives = 362/840 (43%), Gaps = 72/840 (8%)

Query: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
           RAA + N   +   L    D+N  ++     LH+AA        + L    SS++ A + 
Sbjct: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139

Query: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
           G +ALH A  +G  E V +L+ +GA++N   +    PL+ AA   H++V+K L+  GA+ 
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199

Query: 157 STATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLL 212
                 G+  L  A   G  + V  LL    E D        ALHIA        A  L+
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259

Query: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLH 271
               N        VN+  + GFTPLH+AA   N  +   LL+N GA V++ ++ G +PLH
Sbjct: 260 NAGAN--------VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311

Query: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
           +A+  G     ++L+  G +ID   + G TPLH AAR GH+ ++  L+  GA    R  +
Sbjct: 312 MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371

Query: 332 GLSPLHMAAQGDHVECVKHLLQH----------------KAPVDDVTLDYL--TALHVAA 373
            + PLH+A      +C + LL                   A  D  T D L  T LH AA
Sbjct: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431

Query: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 433
             G+     LLL   A+   R   G TPLH A      +    LV  GA +      G +
Sbjct: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491

Query: 434 PIHVAAFMGHLN----------------------------IVLLLLQNGASPDVTNIRGE 465
           P+H AA                                   +  LL NGA P + + +G 
Sbjct: 492 PLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY 551

Query: 466 TALHMAARAGQVEVVRCLLRN--GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
           TA+H AA  G  + +  LL      L D  +    +PLH+A+  G  E ++ L + + + 
Sbjct: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611

Query: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLL 582
           D     G T L ++   G  +   VL   GA+  +   K+ +TPLH AA  G  D   LL
Sbjct: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671

Query: 583 L---QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
           +   +R    D     G TPL +A    +     LLLEKG++  A    G T LH  A  
Sbjct: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731

Query: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK----SG 695
                 + LL++ A       +G TP+HLAS  GHT ++  LL    +          SG
Sbjct: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSG 791

Query: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGAN- 753
            + +H A+     +  ++L +H           +TPL  A           LL   GA  
Sbjct: 792 YSPMHWASYTGHEDCLELLLEHSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKI 850

Query: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           VN++   G TPLH AA   +   + +LLQH A+ NAT   G TAL  A   G  + V+ L
Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910



 Score =  269 bits (688), Expect = 4e-71
 Identities = 230/786 (29%), Positives = 364/786 (46%), Gaps = 60/786 (7%)

Query: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
           AA +G ++ V   L+ G +I+  N  G  ALH+A   G   +  EL+  G++V+    KG
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272

Query: 98  NTALHIASLAGQAEV-VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
            T LH+A+++    + +++LV  GA++N QS+ G +PL+MAA        + L++NG+  
Sbjct: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332

Query: 157 STATEDGFTPLAVALQQGHNQAVAILLEN--DT--KGKVRLPALHIAARKDDTKSAALLL 212
             A + G TPL VA + GH   ++ L+ N  DT  +G   +  LH+A     +     LL
Sbjct: 333 DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392

Query: 213 QNDHNADVQSKMMVNRTTESGF----------TPLHIAAHYGNVNVATLLLNRGAAVDFT 262
            +     + S +       +GF          T LH AA  GNV    LLL+ GA +   
Sbjct: 393 SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452

Query: 263 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS------------G 310
            + G TPLH A+  G+      L+  G  ++     G +PLH AA S             
Sbjct: 453 DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSS 512

Query: 311 HDQ----------------VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
           HD                  +E LL+ GA    R + G + +H AA   + + ++ LL+ 
Sbjct: 513 HDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572

Query: 355 KAP-VDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412
               ++DV     ++ LH+AA+ GH    K L +   N + R   G T L +A ++   +
Sbjct: 573 SFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE 632

Query: 413 VMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR---GETAL 468
            +E+L  +GAS +    +   TP+H AA  GH + + LL+ +G   D+T++    G+T L
Sbjct: 633 CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPL 692

Query: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
            +A   G V+ V  LL  G+  DA     +T LH  +  G  + +  LL H A       
Sbjct: 693 MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752

Query: 529 NGYTPLHISAREGQVDVASVLLEAGAA----HSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
            G TP+H+++  G   V   LL+A  +     +     G++P+H A+  G  D  +LLL+
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812

Query: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQM 642
               +   G N  TPLH A   +      +LL    +    +++  G TPLH AA  + +
Sbjct: 813 HSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNV 871

Query: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG-ANIHMSTKSGLTSLHL 701
                LL + AE N     G T L  A++ G T  V  LL +G A++ +  ++  T+LHL
Sbjct: 872 SGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHL 931

Query: 702 AAQEDKVNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 758
           A  +     A ++     D    +A       PL +A   G   +V  LL  GA V A  
Sbjct: 932 ACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVD 991

Query: 759 KNGYTP 764
           + G+TP
Sbjct: 992 EEGHTP 997



 Score =  246 bits (629), Expect = 2e-64
 Identities = 205/698 (29%), Positives = 296/698 (42%), Gaps = 119/698 (17%)

Query: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
           +  K  +N   +   TPLH AA+ G+V +  LLL  GA V+      +TPLH A+   N 
Sbjct: 28  LSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNE 87

Query: 280 NMVKLLLDRGGQIDAKTRDGLTPLHCAA-------------------------------- 307
            ++ LLL     ++A+ +   TPLH AA                                
Sbjct: 88  KVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHA 147

Query: 308 -RSGHDQVVELLLE---------------------------------RGAPLLARTKNGL 333
             SGH + V LLL                                  RGA L  + + G 
Sbjct: 148 VHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGY 207

Query: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
             LH AA    +E VK+LL+  A +D+      TALH+A + G   V   L++  AN N 
Sbjct: 208 GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267

Query: 394 RALNGFTPLHIAC-KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
               GFTPLH+A    N    +ELLV  GA +   ++ G +P+H+AA  G      +L+Q
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327

Query: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
           NG+  D  +  G T LH+AAR G   ++  L+ NGA    R   +  PLH+A   G ++ 
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDC 387

Query: 513 VQLLL--------------QHM--AHPDAATTN--GYTPLHISAREGQVDVASVLLEAGA 554
            + LL              +H+  A  D  T +  G T LH +A  G V+  ++LL +GA
Sbjct: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGA 447

Query: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA-- 612
                 K G TPLH AA  GS   A  L+   A  + A   G +PLH AA  D  + A  
Sbjct: 448 DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEP 507

Query: 613 --------------------------LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
                                       LL+ GA P    + GYT +H AA     Q   
Sbjct: 508 HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLE 567

Query: 647 TLL--NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
            LL  ++    ++ +   V+PLHLA+  GH + +  L +   N+ +    G T+L LA +
Sbjct: 568 LLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATE 627

Query: 705 EDKVNVADILTKHGADQ-DAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKN 760
                  ++LT HGA       K  +TPL  A   G+   ++ L+  G      +     
Sbjct: 628 RGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAY 687

Query: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
           G TPL  A   GH   +++LL+ G+  +A    G TAL
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725



 Score =  234 bits (597), Expect = 1e-60
 Identities = 186/627 (29%), Positives = 281/627 (44%), Gaps = 49/627 (7%)

Query: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
           PL  A    +V     LL++   ++   +   TPLH A+  G+  +++LLL  G  ++AK
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
               LTPLH AA S +++V+ LLL   A + AR K   +PLH+AA     +C + L    
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 356 APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVME 415
           + ++       +ALH A H GH     LLL+K A+ N        PLH A     ++V++
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 416 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 475
           LLV  GA +      G   +H AA  G + +V  LL+ GA  D  N  G TALH+A   G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250

Query: 476 QVEVVRCLLRNGALVDARAREEQTPLHIAS-RLGKTEIVQLLLQHMAHPDAATTNGYTPL 534
           Q  V   L+  GA V+    +  TPLH+A+        ++LL+ + A  +  +  G +PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594
           H++A  G+   + +L++ G+    A K G TPLHVAA+YG   +   L+   A     G 
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370

Query: 595 NGLTPLHVAAHYDNQKVALLLLEKG---------ASPHATAKN---------GYTPLHIA 636
           + + PLH+A  +        LL  G         ++ H  +           G T LH A
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430

Query: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696
           A    ++  + LL+ GA+     K G TPLH A+  G       L+  GA ++ +   G 
Sbjct: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490

Query: 697 TSLHLAAQEDKVNVA----------------------------DILTKHGADQDAHTKLG 728
           + LH AA  D    A                            + L  +GAD     + G
Sbjct: 491 SPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQG 550

Query: 729 YTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
           YT +  A  YGN + +  LL+   N   + ++    +PLH AA  GH   +  L +    
Sbjct: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610

Query: 787 PNATTANGNTALAIAKRLGYISVVDTL 813
            +     G TAL +A   G    V+ L
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVL 637



 Score =  197 bits (502), Expect = 1e-49
 Identities = 192/673 (28%), Positives = 280/673 (41%), Gaps = 117/673 (17%)

Query: 51   LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110
            L  G DINT +  G   LH AA  G+V  +  LL  G+ +    K G T LH A+  G  
Sbjct: 410  LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469

Query: 111  EVVKVLVKEGANINAQSQNGFTPLYMAAQ-------ENHID------------------- 144
            +    LV  GA +N     G +PL+ AA        E H                     
Sbjct: 470  QCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEA 529

Query: 145  --VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE------NDTKGKVRLPAL 196
               +++LL+NGA+ S     G+T +  A   G+ Q + +LLE       D +  + +  L
Sbjct: 530  FFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPL 589

Query: 197  HIAARKDDTKSAALLLQNDHNADVQS---KMMVNRTTESG-------------------- 233
            H+AA     ++   L +   N DV+    +  +   TE G                    
Sbjct: 590  HLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649

Query: 234  ---FTPLHIAAHYGNVNVATLLLNRGAAVDFTA---RNGITPLHVASKRGNTNMVKLLLD 287
               +TPLH AA  G+ +   LL++ G   D T      G TPL +A   G+ + V LLL+
Sbjct: 650  KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709

Query: 288  RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
            +G   DA    G T LH  A +G +  +  LL+  A +L R   G +P+H+A+   H   
Sbjct: 710  KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAV 769

Query: 348  VKHLLQHKAPVD--DVTLDY--LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
            ++ LLQ     D  D  +DY   + +H A++ GH    +LLL+          N FTPLH
Sbjct: 770  LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLH 828

Query: 404  IACKKNRIKVMELLV-KYGASIQAITES-GLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
             A   N+    E+L+   GA I    ++ G TP+H AAF  +++ + +LLQ+ A  + T+
Sbjct: 829  CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATD 888

Query: 462  IRGETALHMAARAGQVEVVRCLLRNG---------------------------------- 487
              G TAL  AA  GQ   V  LL  G                                  
Sbjct: 889  HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948

Query: 488  ---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 544
                L++A     Q PLHIA+R G   +VQ LL H A   A    G+TP    A     D
Sbjct: 949  QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA--PNKD 1006

Query: 545  VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
            VA  L     A  L+T K F P    + +    +    +   AAA + G  G  P   + 
Sbjct: 1007 VADCL-----ALILSTMKPFPPKDAVSPFSFSLLKNCSI---AAAKTVGGCGALPHGASC 1058

Query: 605  HYDNQKVALLLLE 617
             Y  ++   + L+
Sbjct: 1059 PYSQERPGAIGLD 1071



 Score =  166 bits (419), Expect = 6e-40
 Identities = 118/356 (33%), Positives = 178/356 (50%), Gaps = 1/356 (0%)

Query: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
           + +I  +  L  A  +  VE VR LL     ++   +E +TPLH A+ +G   I+QLLL 
Sbjct: 3   ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62

Query: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
             A+ +A  T   TPLH +A      V  +LL   A  +   K   TPLHVAA   +   
Sbjct: 63  SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122

Query: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
           A+ L    ++ + A ++G + LH A H  + +   LLL KGAS +   K    PLH AA 
Sbjct: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182

Query: 639 KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS 698
              +++   L+  GA+     ++G   LH A+  G  ++V  LL  GA I      G T+
Sbjct: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242

Query: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM-VNFLLKQGANVNAK 757
           LH+A    +  VA  L   GA+ +     G+TPL VA    N  + +  L+  GA+VN +
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302

Query: 758 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           +K G +PLH AA  G      +L+Q+G++ +     GNT L +A R G+  ++ TL
Sbjct: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358



 Score = 87.4 bits (215), Expect = 3e-16
 Identities = 61/190 (32%), Positives = 88/190 (46%)

Query: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690
           TPLH AA    + I   LL  GA  N      +TPLH A+   +  ++ LLL   A+++ 
Sbjct: 43  TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102

Query: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
             K   T LH+AA       A+ L    +  +   + G + L  A H G+++ VN LL +
Sbjct: 103 RDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162

Query: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
           GA++N   K    PLH AA  GH  ++ +L+  GA        G   L  A   G I VV
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVV 222

Query: 811 DTLKVVTEEV 820
             L  +  E+
Sbjct: 223 KYLLRMGAEI 232


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  249 bits (637), Expect = 3e-65
 Identities = 166/475 (34%), Positives = 267/475 (56%), Gaps = 8/475 (1%)

Query: 340 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG- 398
           ++GD V  V+ LL     V++ T +  + L +A   G+Y + ++LL   AN   R + G 
Sbjct: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301

Query: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
            TPL  A     +K+++LL+ + A + A + +G T +  A   G++++V +LL++GAS +
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361

Query: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLL 517
             N  G T L  A  AG VEV R LL NGA ++  + E +++ L +A   G  E+V+ LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421

Query: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
           +  A  +  T   +T L  +  +G V+VA +LL++GA  ++      +PL +AA  G ++
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481

Query: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIA 636
           +A LL++R A+ +     G TPL  AA   ++++  LLL +GA+ +A T +   T L +A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696
                +++A  L+  GA+  +      TPL  A+QEGH ++V  LL  GAN+H +T +G 
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598

Query: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756
           T+L  A +    +VAD+L + GAD +  ++ G TPL+ A   G+V  V FL+ +GANVN 
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658

Query: 757 KT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
            T  N +T L  A   GH  ++ +LL HGA P     +G+T L  A + G+ SVV
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713



 Score =  221 bits (563), Expect = 1e-56
 Identities = 174/529 (32%), Positives = 264/529 (49%), Gaps = 23/529 (4%)

Query: 32  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
           N S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+
Sbjct: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294

Query: 92  SATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
               KG+ T L  A+  G  ++VK+L+   A++NAQS  G T L  A    ++DVVK LL
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354

Query: 151 ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT-----KGKVRLPALHIAARKDDT 205
           E+GA+     E+G TPL  A   GH +   +LLEN         + +  AL +A  K   
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
           +    LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +
Sbjct: 415 EMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466

Query: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
             +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA +
Sbjct: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 326 LARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
            A+T+    + L +A  G  +E    L++  A   D+ L   T L  AA  GH  + K L
Sbjct: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYL 583

Query: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
           L   AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GH+
Sbjct: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643

Query: 445 NIVLLLLQNGASPDVTNIRGE-TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
             V  L+  GA+ + T    + T L +A   G + VV  LL +GA    R ++  T L  
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703

Query: 504 ASRLGKTEIVQLLLQH----MAHPDAATTNGYTPLHISAREGQVDVASV 548
           A++ G T +V  LL +    ++ P    T    P H   R  +V V ++
Sbjct: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL 752



 Score =  217 bits (553), Expect = 2e-55
 Identities = 169/489 (34%), Positives = 246/489 (50%), Gaps = 13/489 (2%)

Query: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKN 331
           A   G+ N V+ LL  G  ++  T +G + L  A  +G+ ++ ++LL   A +  R  K 
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
            ++PL  AA G HV+ VK LL HKA V+  +    TAL  A   G+  V K+LL+  A+ 
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447
                NG TPL  A     ++V  LL++ GA I        ES LT   +A + GHL +V
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT---LACYKGHLEMV 417

Query: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477

Query: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TP 566
           G  E+  LL++  A  +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETA 537

Query: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
           L +A   G L+VA  L++  A  +       TPL  AA   + ++   LL  GA+ HAT 
Sbjct: 538 LTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATT 594

Query: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
             G T L  A +     +A  LL  GA+    ++ G TPL  A++ GH   V  L+ KGA
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGA 654

Query: 687 NIHMSTKSG-LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
           N++ +T +   T L LA     + V ++L  HGAD     K G T LI A   G+  +V 
Sbjct: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714

Query: 746 FLLKQGANV 754
           +LL    N+
Sbjct: 715 YLLDYPNNL 723



 Score =  215 bits (547), Expect = 8e-55
 Identities = 168/518 (32%), Positives = 259/518 (50%), Gaps = 12/518 (2%)

Query: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM----VNRTTESGFTPLHIAAHYGN 245
           ++R  +   A + D+   A    + D NA V+  ++    VN  TE G + L +A   G 
Sbjct: 221 RMRAESTANAGQSDNRSLAEACSEGDVNA-VRKLLIEGRSVNEHTEEGESLLCLACSAGY 279

Query: 246 VNVATLLLNRGAAVDFTARNG-ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304
             +A +LL   A V+     G ITPL  A+  G+  +VKLLL     ++A++  G T L 
Sbjct: 280 YELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALT 339

Query: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
            A   G+  VV++LLE GA +    +NG +PL  A    HVE  + LL++ A ++  + +
Sbjct: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399

Query: 365 YL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
           +  +AL +A + GH  + + LL+  A+   +     T L  AC    ++V  LL+  GA 
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 459

Query: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
           +    +S  +P+ +AA  GH+ +  LL++ GAS +  N  G T L  AAR G  E+V  L
Sbjct: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519

Query: 484 LRNGALVDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
           L  GA ++A+  E Q T L +A   G  E+   L++  A  +   +   TPL  +A+EG 
Sbjct: 520 LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGH 576

Query: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
           +++   LL AGA     T  G T L  A + G  DVA +LLQ  A  +   + G TPL  
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 603 AAHYDNQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661
           AA   +      L+ KGA+ +  TA N +T L +A     + +   LL +GA+     K 
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696

Query: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
           G T L  A++ GHT +V  LLD   N+  +    +T L
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734



 Score =  199 bits (506), Expect = 5e-50
 Identities = 160/483 (33%), Positives = 241/483 (49%), Gaps = 16/483 (3%)

Query: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
           KA  D   L  LT+   +  C        L   RA   A A  +    L  AC +  +  
Sbjct: 193 KAFADPEVLRRLTS---SVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNA 249

Query: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE-TALHMAA 472
           +  L+  G S+   TE G + + +A   G+  +  +LL   A+ +   I+G+ T L  AA
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309

Query: 473 RAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532
             G V++V+ LL + A V+A++    T L  A   G  ++V++LL+  A  +    NG+T
Sbjct: 310 NGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369

Query: 533 PLHISAREGQVDVASVLLEAGAA---HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
           PL  +   G V+VA +LLE GA    HS   K+  + L +A   G L++ + LL+  A  
Sbjct: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKE--SALTLACYKGHLEMVRFLLEAGADQ 427

Query: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
           +       T L  A    + +VA LLL+ GA  +  A +  +PL +AA    +++A+ L+
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487

Query: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKV 708
             GA    V  +G TPL  A++EGH +MV LLL +GANI+  T+    T+L LA     +
Sbjct: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547

Query: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
            VAD L K GAD +       TPL+ A   G++++V +LL  GANV+A T  G T L  A
Sbjct: 548 EVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYA 604

Query: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT 828
            + GHT + +VLLQ GA     +  G T L  A R G++  V  L  +++      TT  
Sbjct: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL--ISKGANVNRTTAN 662

Query: 829 EKH 831
             H
Sbjct: 663 NDH 665



 Score =  191 bits (486), Expect = 9e-48
 Identities = 217/844 (25%), Positives = 354/844 (41%), Gaps = 100/844 (11%)

Query: 30   DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
            + +   + A  AG+++     L+ G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 366  NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425

Query: 89   SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
              +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 426  DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485

Query: 149  LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
            L+E GA+     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 486  LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQET 536

Query: 209  ALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
            AL L         +  ++    +      TPL  AA  G++ +   LL  GA V  T   
Sbjct: 537  ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTAT 596

Query: 266  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
            G T L  A + G+T++  +LL  G  ++ ++  G TPL  AAR+GH   V+ L+ +GA +
Sbjct: 597  GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656

Query: 326  LART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
               T  N  + L +A  G H+  V+ LL H A       D  T L  AA  GH  V   L
Sbjct: 657  NRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716

Query: 385  LDKRAN----PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
            LD   N    P         P H   +  R+ V  L       +    E    P +VA  
Sbjct: 717  LDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL-----PMVVPPQEPDKPPANVA-- 769

Query: 441  MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500
                    L ++N A+      + +++ H+ A +  V+         ++V+  A+ + T 
Sbjct: 770  ------TTLPIRNKAAS-----KQKSSSHLPANSQDVQGYITNQSPESIVE-EAQGKLTE 817

Query: 501  LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE--AGAAHSL 558
            L    +    +  QL    +AH D  T      L+   RE Q+     +LE        L
Sbjct: 818  LEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELN-KTREEQIQKKQKILEELQKVEREL 876

Query: 559  ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL---- 614
              K   T   +  +Y  +   ++ LQ++          LTP+ V         A L    
Sbjct: 877  QLK---TQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVD 933

Query: 615  -LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE- 672
             +L K       A+ G+ P+   A    + +A+  L  G+  N+   QGV    +  Q  
Sbjct: 934  PVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGV----IVGQPV 989

Query: 673  -GHTDMVTLLLDKGANIHMSTKSGLTSLH------------LAAQEDKVNVADILTKH-- 717
             G   +  L    G  I   T+ GL                +AA   + +       H  
Sbjct: 990  LGQAQLAGL----GQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSI 1045

Query: 718  --------------------------GADQDAHTKLGY-TPLIVACHYGNVKMVNFLLKQ 750
                                        D DA T+  + T L +AC  G+ ++V  LL++
Sbjct: 1046 AASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLER 1105

Query: 751  GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNTALAIAKRLGYISV 809
            GA++  + K G+TPL  AA  GH  ++ +LL +GA   A +    +T L++A   G   V
Sbjct: 1106 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 1165

Query: 810  VDTL 813
            V+ L
Sbjct: 1166 VELL 1169



 Score =  174 bits (440), Expect = 2e-42
 Identities = 158/550 (28%), Positives = 257/550 (46%), Gaps = 26/550 (4%)

Query: 424  IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
            I A TES   T + +A   GH  +V  LL+ GAS +  + +G T L +AA AG V VV  
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134

Query: 483  LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
            LL NGA ++A++ R + TPL +A   G+ E+V+LLL   A+ +    + YTPL ++A  G
Sbjct: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194

Query: 542  QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598
             V++  +LL AGA  +  T  K G +PL +AA  G     KLLL   +  ++  + N  T
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254

Query: 599  PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657
             L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ GA+ N  
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314

Query: 658  -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
             V     T L +A+ +GH     LL+ +GA+I +  K G T L LAA    ++V  +L +
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374

Query: 717  HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV--NAKTKNGYTPLHQAAQQGHT 774
             GAD DA      TPL+ A   G+VK+V +L+K+      +++       +         
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434

Query: 775  HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH--- 831
            H+    +       A  AN N ++ + +       +D  K+  E          EK    
Sbjct: 1435 HLCMESIVQAKDRQAAEANKNASILLEE-------LDLEKLREESRRLALAAKREKRKEK 1487

Query: 832  ---KLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKE-LGDDSLPSSQFLDGMNYL 887
               K        E ++  ++E  +       E L+ ED  E L +    ++    G++  
Sbjct: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISAT 1547

Query: 888  RYSLEGG---RSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNS 944
              +L G    R++++ + SS R +  +  +      + DD + I   Q   +  E++ +S
Sbjct: 1548 WTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSS 1607

Query: 945  YRLSWGTENL 954
               S  ++N+
Sbjct: 1608 TSESGDSDNM 1617



 Score =  171 bits (433), Expect = 1e-41
 Identities = 122/334 (36%), Positives = 185/334 (55%), Gaps = 9/334 (2%)

Query: 226  VNRTTESGF-TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
            ++  TES   T L +A   G+  +   LL RGA+++   + G TPL +A+  G+  +V++
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134

Query: 285  LLDRGGQIDAKT-RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
            LLD G  I+A++ R   TPL  A   G  +VVELLL RGA    R  +  +PL +AA G 
Sbjct: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194

Query: 344  HVECVKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNAR-ALNGFT 400
            +V  +K LL   A ++  T   L  + L +AA  GH    KLLLD  ++ NA+   N  T
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254

Query: 401  PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA---SP 457
             L +AC + R +V+ LL+   A+++   ++GLTP+  AA  G+  +  +LL  GA   +P
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314

Query: 458  DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
             V + R +TAL +AA  G  +    L+  GA +D R ++  TPL +A+  G  ++VQLL+
Sbjct: 1315 PVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373

Query: 518  QHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
            Q  A  DAA     TPL  + R+G V V   L++
Sbjct: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  163 bits (412), Expect = 4e-39
 Identities = 112/354 (31%), Positives = 193/354 (54%), Gaps = 20/354 (5%)

Query: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
            +S+ + +   A   G+ + V   L+ G  I   ++ G   L LAA  GHVG+V+ LL  G
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139

Query: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
            + +++ +++  +T L +A   G+ EVV++L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199

Query: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259

Query: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
              +  T+  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1311

Query: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  AA  GH  VV+L
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371

Query: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATI 1425



 Score =  162 bits (411), Expect = 5e-39
 Identities = 130/370 (35%), Positives = 185/370 (50%), Gaps = 42/370 (11%)

Query: 122  NINAQSQ-NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
            +I+AQ++ N  T L +A    H ++V+ LLE GA+     + GFTPL +A   GH   V 
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 181  ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
            ILL+N            I A+ + TK                            TPL +A
Sbjct: 1134 ILLDNGAD---------IEAQSERTKD---------------------------TPLSLA 1157

Query: 241  AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-- 298
               G   V  LLL RGA  +    +  TPL +A+  G  N++K+LL+ G +I+++T    
Sbjct: 1158 CSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 1217

Query: 299  GLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAP 357
            G++PL  AA +GH   V+LLL+ G+ + A+ + N  + L +A      E V  LL  KA 
Sbjct: 1218 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKAN 1277

Query: 358  VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF--TPLHIACKKNRIKVME 415
            V+      LT L  AA  G+  V ++LLDK A+ NA  +     T L IA  K   K  E
Sbjct: 1278 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1337

Query: 416  LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 475
            LL+  GA I    + G TP+ +AA  GHL++V LL+Q GA  D  + R  T L  A R G
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397

Query: 476  QVEVVRCLLR 485
             V+VVR L++
Sbjct: 1398 HVKVVRYLVK 1407



 Score =  153 bits (387), Expect = 3e-36
 Identities = 115/331 (34%), Positives = 169/331 (51%), Gaps = 10/331 (3%)

Query: 262  TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
            T  N  T L +A   G+  +V+ LL+RG  I+ + + G TPL  AA +GH  VVE+LL+ 
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138

Query: 322  GAPLLA---RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
            GA + A   RTK+  +PL +A  G   E V+ LL   A  +   +   T L +AA  G+ 
Sbjct: 1139 GADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV 1196

Query: 379  RVTKLLLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPI 435
             + K+LL+  A  N+R  +  G +PL +A        ++LL+  G+ I A  E+   T +
Sbjct: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256

Query: 436  HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-- 493
             +A F G   +V LLL   A+ +     G T L  AA  G  EV R LL  GA V+A   
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316

Query: 494  AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
                 T L IA+  G  +  +LL+   AH D     G TPL ++A  G +DV  +L++AG
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376

Query: 554  AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
            A    A  +  TPL  A + G + V + L++
Sbjct: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  117 bits (293), Expect = 2e-25
 Identities = 101/333 (30%), Positives = 147/333 (44%), Gaps = 69/333 (20%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131
           G+S++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549

Query: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
                           TPL  AAQE H+++VKYLL  GAN    T  G T L  A + GH
Sbjct: 550 ADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH 609

Query: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
                +LL+                                 AD++ +      +E G T
Sbjct: 610 TDVADVLLQ-------------------------------AGADLEHE------SEGGRT 632

Query: 236 PLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
           PL  AA  G+V     L+++GA V+  TA N  T L +A   G+  +V+LLL  G     
Sbjct: 633 PLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTH 692

Query: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
           + +DG T L  AA+ GH  VV  LL+    LL+
Sbjct: 693 RLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLS 725



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 10/180 (5%)

Query: 36   LRAARAGNLDKVVEYLKGGIDINT--CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
            + AA  G  +     L  G D+N      +   AL +AA +GH    + L+GRG+ +D  
Sbjct: 1290 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349

Query: 94   TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
             KKGNT L +A+  G  +VV++LV+ GA+++A      TPL  A ++ H+ VV+YL++  
Sbjct: 1350 NKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE- 1408

Query: 154  ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
             NQ  +  +    +A    +   +   + +E+  + K R  A       +  K+A++LL+
Sbjct: 1409 VNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAA-------EANKNASILLE 1461



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 2/95 (2%)

Query: 26   PKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELL 84
            P  S  + +   AA  G+  K  E L G G  I+  N+ G   L LAA  GH+ +VQ L+
Sbjct: 1315 PVPSSRDTALTIAADKGHY-KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373

Query: 85   GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
              G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408



 Score = 42.0 bits (97), Expect = 0.012
 Identities = 57/238 (23%), Positives = 97/238 (40%), Gaps = 18/238 (7%)

Query: 1701 KKPVRRKLKEKQKQKEEGLQA-SAEKAELKKGSSEESL--GEDPGLAPEPLPTVKATSPL 1757
            +K  RRK KE+Q++K E ++A + E  EL+    +E L   ++P +  EP      T+  
Sbjct: 1484 RKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIG 1543

Query: 1758 IE---ETPIGSIKDKVKALQKRVEDEQKGRSKL-PIRVKGKEDVPKKTTH-RPHPAASPS 1812
            I     T  GS   +   +       +  ++K+ P  V+   D P   ++ +P      S
Sbjct: 1544 ISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGES 1603

Query: 1813 LKSERHAPGSP-----SPKTERHSTLSSSAKTERHPP--VSPSSKTEKHSPVSPSAKTER 1865
              S     G       S  ++  S  +SS K++ H P  V+ +  ++K   V  +   E 
Sbjct: 1604 KSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEE 1663

Query: 1866 HSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTE 1923
                S  +  +    +S  T    +S  + TK+   P  SP+GK     P     R E
Sbjct: 1664 RKSVSGKASIKLSETISEGTS---NSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREE 1718



 Score = 38.5 bits (88), Expect = 0.13
 Identities = 43/151 (28%), Positives = 59/151 (39%), Gaps = 20/151 (13%)

Query: 1798 PKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPV 1857
            P  T    +P +SPS  S    PG  S    R+S L   + +     V+ SS+ E  SP 
Sbjct: 2030 PMPTAKEHYPVSSPSSPSPPAQPGGVS----RNSPLDCGSASPN--KVASSSEQEAGSP- 2082

Query: 1858 SPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPP-----VSPSGKTDK 1912
             P  +T    P +SSS     S  S S  + +  P  S   E  PP     V P      
Sbjct: 2083 -PVVETTNTRPPNSSS-----SSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 2136

Query: 1913 RPPVSPSGRTEKHPPVSPGRTEKRLPVSPSG 1943
             PP++ S      P  +P      +P +P G
Sbjct: 2137 VPPLATSSAPVAVPSTAP--VTYPMPQTPMG 2165



 Score = 35.4 bits (80), Expect = 1.1
 Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 33/204 (16%)

Query: 1801 TTHRPHPAASPSLKSERHAPGSPSPKTERHSTL--SSSAKTERHPPVSPSSKTEKHSPVS 1858
            TT     A++    S   +P SPS + +   T+  +S+A T      + ++ T   +   
Sbjct: 1970 TTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATY 2029

Query: 1859 PSAKTERHSPASSSSK---------TEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGK 1909
            P    + H P SS S            ++SP+   + +      SS +    PPV  +  
Sbjct: 2030 PMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVET-- 2087

Query: 1910 TDKRPP--VSPSGRTEKH---------------PPVSPGRT---EKRLPVSPSGRTDKHQ 1949
            T+ RPP   S SG +  H               PP+   +    E R+ V P   +    
Sbjct: 2088 TNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPV 2147

Query: 1950 PVSTAGKTEKHLPVSPSGKTEKQP 1973
             V +       +P +P G  +  P
Sbjct: 2148 AVPSTAPVTYPMPQTPMGCPQPTP 2171


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  237 bits (605), Expect = 2e-61
 Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)

Query: 315 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 363
           V   L+  A  L R K   S  H A Q D            V  V+ LL     V++ T 
Sbjct: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 422
           +  + L +A   G+Y + ++LL   AN   R   G  TPL  A     + +++LL+ + A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296

Query: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
            + + + +G T +  A   G ++IV +LL  GA+ +  N  G T L  AA AG VEV R 
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356

Query: 483 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
           LL +GA ++  + E +++ L +A   G  ++V+ LL+  A  +  T   +T L  +  +G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416

Query: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
            V+VA +LL++GA  ++      +PL +AA  G +++A LL++R A  +     G TPL 
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476

Query: 602 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
            AA   ++++  LLL +GA+ +A T +   T L +A      ++A  L+  GA+  +   
Sbjct: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536

Query: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
              TPL  ASQEGH ++V  LL  GAN+H +T +G T+L  A +    +VAD+L + GAD
Sbjct: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 779
            +  ++ G TPL+ A   G++  V FL+ +GANVN A   N +T +  A   GH  ++ +
Sbjct: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653

Query: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 833
           LL HGA P     +G+T L  A + G+ +VV  L      V +  TT         + + 
Sbjct: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713

Query: 834 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 877
            VP   T  L         D + +E    + G   G    +   L+    D LPS
Sbjct: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768



 Score =  214 bits (544), Expect = 2e-54
 Identities = 163/494 (32%), Positives = 245/494 (49%), Gaps = 19/494 (3%)

Query: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439

Query: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556

Query: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
             AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GHL  
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616

Query: 447 VLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
           V  L+  GA+ +  T     T + +A   G + VV  LL +GA    R ++  T L  A+
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676

Query: 506 RLGKTEIVQLLLQH 519
           + G T +V  LL +
Sbjct: 677 KGGHTNVVSYLLDY 690



 Score =  163 bits (412), Expect = 4e-39
 Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)

Query: 143  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
            I  V   +  G+N S+ T +  TP + + Q   N A   +           P++ I A  
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051

Query: 203  DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 256
            +     AL L      +    +++ R  +       GFTPL +AA  G+V V  +LL++G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 257  AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
              ++  + R   TPL +A   G   +V LLL RG   + +     TPL  AA  G+  ++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 316  ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 372
            ++LL  GA + +RT  K G+SPL +AA   HV  VK LL   + ++  +  +  TAL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 373  AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 430
               G   V  LLLD++AN   RA  G TPL  A      +V  +L+  GA + A  +  S
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291

Query: 431  GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
              T + +AA  GH     LL+  GA  DV N +G T L +A+  G  +VV+ L++ GA V
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351

Query: 491  DARAREEQTPLHIASRLGKTEIVQLLLQHM 520
            DA    + TPL  A R G  ++VQ L++ +
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381



 Score =  161 bits (407), Expect = 1e-38
 Identities = 121/408 (29%), Positives = 197/408 (48%), Gaps = 41/408 (10%)

Query: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396

Query: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456

Query: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507

Query: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537

Query: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L   
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597

Query: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDK 387
           ++ G +PL  AA+  H+  V+ L+   A V+  T +   T + +A   GH  V +LLL  
Sbjct: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657

Query: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
            A+P  R  +G T L  A K     V+  L+ Y  ++ ++  + ++ +
Sbjct: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705



 Score =  161 bits (407), Expect = 1e-38
 Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)

Query: 424  IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
            I A TES   T + +A   GH  +V +L+   A  +  + +G T L +AA AG V VV  
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 483  LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
            LL  G  ++A++ R + TPL +A   G+ E+V LLL   A+ +    + YTPL ++A  G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 542  QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598
             V++  +LL AGA  +  T  K G +PL +AA  G +   KLLL   +  ++  + N  T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226

Query: 599  PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657
             L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ GA+ N  
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 658  -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
             V     T L +A+ +GH     LL+ +GA+I +  K G T L LA+     +V  +L +
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 717  HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
             GAD DA      TPL+ A   G+VK+V +L+K+
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  152 bits (384), Expect = 6e-36
 Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)

Query: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
            +S+ + +   A   G+ + V   +     I   ++ G   L LAA  GHVG+V+ LL +G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
              +++ +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
              +   +  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  A+  GH  VV+L
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397



 Score =  145 bits (365), Expect = 1e-33
 Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)

Query: 490  VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
            +DA       T L +A   G  E+V +L+   A  +     G+TPL ++A  G V V  +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 549  LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
            LL+ G    A S  TK   TPL +A   G  +V  LLL R A  +    +  TPL +AA 
Sbjct: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 606  YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 662
                 +  +LL  GA  ++   +K G +PL +AA    +     LL+ G++ N  +    
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 663  VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
             T L LA  +G  ++V+LLLD+ AN+    K+GLT L  AA      V  +L   GAD +
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 723  AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
            A        T L +A   G+ K    L+ +GA+++ + K G TPL  A+  GH  ++ +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 834
            +Q GA  +A      T L  A R G++ VV  L K V +     E      TIT+K  L 
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404

Query: 835  VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 874
                  E +  + ++       +    L+  DL++  ++S
Sbjct: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444



 Score =  115 bits (289), Expect = 7e-25
 Identities = 99/347 (28%), Positives = 153/347 (44%), Gaps = 69/347 (19%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 521 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580

Query: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
                +LL+                                 AD++ +      +E G T
Sbjct: 581 TDVADVLLQ-------------------------------AGADLEHE------SEGGRT 603

Query: 236 PLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
           PL  AA  G++     L+++GA V+  TA N  T + +A   G+  +V+LLL  G     
Sbjct: 604 PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTH 663

Query: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ 341
           + +DG T L  AA+ GH  VV  LL+    +L+     +S L   +Q
Sbjct: 664 RLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQ 710



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/94 (32%), Positives = 45/94 (47%)

Query: 26   PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
            P  S  + +   AA  G+       +  G  I+  N+ G   L LA+  GH  +VQ L+ 
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 86   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
             G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  237 bits (605), Expect = 2e-61
 Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)

Query: 315 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 363
           V   L+  A  L R K   S  H A Q D            V  V+ LL     V++ T 
Sbjct: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 422
           +  + L +A   G+Y + ++LL   AN   R   G  TPL  A     + +++LL+ + A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296

Query: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
            + + + +G T +  A   G ++IV +LL  GA+ +  N  G T L  AA AG VEV R 
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356

Query: 483 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
           LL +GA ++  + E +++ L +A   G  ++V+ LL+  A  +  T   +T L  +  +G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416

Query: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
            V+VA +LL++GA  ++      +PL +AA  G +++A LL++R A  +     G TPL 
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476

Query: 602 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
            AA   ++++  LLL +GA+ +A T +   T L +A      ++A  L+  GA+  +   
Sbjct: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536

Query: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
              TPL  ASQEGH ++V  LL  GAN+H +T +G T+L  A +    +VAD+L + GAD
Sbjct: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 779
            +  ++ G TPL+ A   G++  V FL+ +GANVN A   N +T +  A   GH  ++ +
Sbjct: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653

Query: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 833
           LL HGA P     +G+T L  A + G+ +VV  L      V +  TT         + + 
Sbjct: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713

Query: 834 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 877
            VP   T  L         D + +E    + G   G    +   L+    D LPS
Sbjct: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768



 Score =  214 bits (544), Expect = 2e-54
 Identities = 163/494 (32%), Positives = 245/494 (49%), Gaps = 19/494 (3%)

Query: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439

Query: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556

Query: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
             AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GHL  
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616

Query: 447 VLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
           V  L+  GA+ +  T     T + +A   G + VV  LL +GA    R ++  T L  A+
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676

Query: 506 RLGKTEIVQLLLQH 519
           + G T +V  LL +
Sbjct: 677 KGGHTNVVSYLLDY 690



 Score =  163 bits (412), Expect = 4e-39
 Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)

Query: 143  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
            I  V   +  G+N S+ T +  TP + + Q   N A   +           P++ I A  
Sbjct: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051

Query: 203  DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 256
            +     AL L      +    +++ R  +       GFTPL +AA  G+V V  +LL++G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 257  AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
              ++  + R   TPL +A   G   +V LLL RG   + +     TPL  AA  G+  ++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 316  ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 372
            ++LL  GA + +RT  K G+SPL +AA   HV  VK LL   + ++  +  +  TAL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 373  AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 430
               G   V  LLLD++AN   RA  G TPL  A      +V  +L+  GA + A  +  S
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291

Query: 431  GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
              T + +AA  GH     LL+  GA  DV N +G T L +A+  G  +VV+ L++ GA V
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351

Query: 491  DARAREEQTPLHIASRLGKTEIVQLLLQHM 520
            DA    + TPL  A R G  ++VQ L++ +
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381



 Score =  161 bits (407), Expect = 1e-38
 Identities = 121/408 (29%), Positives = 197/408 (48%), Gaps = 41/408 (10%)

Query: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396

Query: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456

Query: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507

Query: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537

Query: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L   
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597

Query: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDK 387
           ++ G +PL  AA+  H+  V+ L+   A V+  T +   T + +A   GH  V +LLL  
Sbjct: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657

Query: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
            A+P  R  +G T L  A K     V+  L+ Y  ++ ++  + ++ +
Sbjct: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705



 Score =  161 bits (407), Expect = 1e-38
 Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)

Query: 424  IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
            I A TES   T + +A   GH  +V +L+   A  +  + +G T L +AA AG V VV  
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 483  LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
            LL  G  ++A++ R + TPL +A   G+ E+V LLL   A+ +    + YTPL ++A  G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 542  QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598
             V++  +LL AGA  +  T  K G +PL +AA  G +   KLLL   +  ++  + N  T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226

Query: 599  PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657
             L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ GA+ N  
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 658  -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
             V     T L +A+ +GH     LL+ +GA+I +  K G T L LA+     +V  +L +
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 717  HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
             GAD DA      TPL+ A   G+VK+V +L+K+
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  152 bits (384), Expect = 6e-36
 Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)

Query: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
            +S+ + +   A   G+ + V   +     I   ++ G   L LAA  GHVG+V+ LL +G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
              +++ +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
              +   +  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  A+  GH  VV+L
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397



 Score =  145 bits (365), Expect = 1e-33
 Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)

Query: 490  VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
            +DA       T L +A   G  E+V +L+   A  +     G+TPL ++A  G V V  +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 549  LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
            LL+ G    A S  TK   TPL +A   G  +V  LLL R A  +    +  TPL +AA 
Sbjct: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 606  YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 662
                 +  +LL  GA  ++   +K G +PL +AA    +     LL+ G++ N  +    
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 663  VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
             T L LA  +G  ++V+LLLD+ AN+    K+GLT L  AA      V  +L   GAD +
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 723  AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
            A        T L +A   G+ K    L+ +GA+++ + K G TPL  A+  GH  ++ +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 834
            +Q GA  +A      T L  A R G++ VV  L K V +     E      TIT+K  L 
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404

Query: 835  VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 874
                  E +  + ++       +    L+  DL++  ++S
Sbjct: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444



 Score =  115 bits (289), Expect = 7e-25
 Identities = 99/347 (28%), Positives = 153/347 (44%), Gaps = 69/347 (19%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 521 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580

Query: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
                +LL+                                 AD++ +      +E G T
Sbjct: 581 TDVADVLLQ-------------------------------AGADLEHE------SEGGRT 603

Query: 236 PLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
           PL  AA  G++     L+++GA V+  TA N  T + +A   G+  +V+LLL  G     
Sbjct: 604 PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTH 663

Query: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ 341
           + +DG T L  AA+ GH  VV  LL+    +L+     +S L   +Q
Sbjct: 664 RLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQ 710



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/94 (32%), Positives = 45/94 (47%)

Query: 26   PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
            P  S  + +   AA  G+       +  G  I+  N+ G   L LA+  GH  +VQ L+ 
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 86   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
             G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  233 bits (594), Expect = 3e-60
 Identities = 138/385 (35%), Positives = 207/385 (53%)

Query: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
           +N ++PLH       VE V+ LL H+  VD  T    T L +AA      +  LLL   A
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 449
           + N    +G+ PLH A +        LL+ +GA + A    G TP+H+AA     N+  L
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
           L+   A P++    G+T LH+AA  G V +V+ L   GA +DA+ R  +TPLH+A   GK
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
              +Q LL+  A PDA   +GY PLH +A  G+  +  +LL  GA+  L T +G+TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
           AA  G L++  LL +  A   + G    TPLH+AA +  + V   LL+ GA P+A  ++G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
           +TPLH+A +++       LL + A  +   K G TP HLA+ +G+T ++ +L++ GA + 
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719

Query: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714
           +      T L LA +  K  +   L
Sbjct: 720 VQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  223 bits (569), Expect = 2e-57
 Identities = 140/377 (37%), Positives = 204/377 (54%)

Query: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
           I E+ +TP+H     G +  V LLL +    D     G T L +AA+  Q ++   LL +
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
           GA  +    +   PLH A++ G     +LLL H A  DA    G+TPLH++A+    +VA
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477

Query: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606
            +L+   A  +L   +G TPLHVAA +G + + KLL  + A  D+  +N  TPLH+A   
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537

Query: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
              +    LL+ GA P A  ++GY PLH AA + +  I   LL YGA   + T QG TPL
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597

Query: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
           HLA+ +GH +++ LL +  AN+        T LHLAA+  +  V   L + GAD +A  +
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657

Query: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
            G+TPL +A        V  LL+  ANV+A+ K G+TP H AA +G+T I+ VL++ GA+
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717

Query: 787 PNATTANGNTALAIAKR 803
            +       T L +A R
Sbjct: 718 LDVQDGVSCTPLQLALR 734



 Score =  221 bits (564), Expect = 9e-57
 Identities = 138/402 (34%), Positives = 212/402 (52%), Gaps = 2/402 (0%)

Query: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290
           E+  TPLH     G+V    LLL     VD    +G TPL +A++    ++  LLL  G 
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
             +    DG  PLH AA++G D    LLL+ GA + A+ + G +PLH+AAQ +     + 
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410
           L+  +A  +    +  T LHVAA+ GH  + KLL  + A  +A+  N  TPLH+A ++ +
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
           ++ ++ L+K GA   A+ +SG  P+H AA  G   I  +LL+ GAS ++   +G T LH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
           AA  G +E++  L  + A + A      TPLH+A+R G+  +V  LLQ  A P+AA  +G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
           +TPLH++ +         LLE  A      K G+TP H+AA  G+  + K+L++  A  D
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719

Query: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 632
                  TPL +A    ++K  ++   +G  P      G  P
Sbjct: 720 VQDGVSCTPLQLALR--SRKQGIMSFLEGKEPSVATLGGSKP 759



 Score =  221 bits (564), Expect = 9e-57
 Identities = 139/401 (34%), Positives = 205/401 (51%), Gaps = 2/401 (0%)

Query: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
           N +TPLH    +G+   V+LLL     +D +T  G TPL  AA+     +  LLL  GA 
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
                ++G +PLH AAQ       + LL H A VD    +  T LH+AA      V +LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
           + ++A+PN     G TPLH+A     + +++LL   GA + A   +  TP+H+A   G +
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504
             +  LL++GA PD  +  G   LH AA  G+  + + LLR GA ++    +  TPLH+A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 505 SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 564
           +  G  EI+ LL +  A+  A     +TPLH++AR G+  V S LL+ GA  + A + G+
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
           TPLH+A +  +      LL+  A   +  K G TP H+AA   N  +  +L+E GA    
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720

Query: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665
                 TPL +A +  +  I S L   G E ++ T  G  P
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759



 Score =  221 bits (564), Expect = 9e-57
 Identities = 136/381 (35%), Positives = 202/381 (53%), Gaps = 8/381 (2%)

Query: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251
           ++  LH    +   +   LLL ++ + D Q        T SG+TPL IAA     ++  L
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQ--------TASGYTPLLIAAQDQQPDLCAL 413

Query: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
           LL  GA  +    +G  PLH A++ G+    +LLLD G  +DA+ R+G TPLH AA++  
Sbjct: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473

Query: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371
           + V  LL+ R A        G +PLH+AA   HV  VK L    A +D    +  T LH+
Sbjct: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533

Query: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
           A   G  R  + LL   A P+A   +G+ PLH A  + +  + ++L++YGAS++  T  G
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593

Query: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
            TP+H+AA+ GHL I+ LL ++ A+         T LH+AAR G+  VV  LL+ GA  +
Sbjct: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653

Query: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
           A  +   TPLH+A +      V  LL+H A+  A    G+TP H++A +G   +  VL+E
Sbjct: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713

Query: 552 AGAAHSLATKKGFTPLHVAAK 572
           AGA   +      TPL +A +
Sbjct: 714 AGAQLDVQDGVSCTPLQLALR 734



 Score =  218 bits (555), Expect = 9e-56
 Identities = 137/389 (35%), Positives = 203/389 (52%)

Query: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
           +TPLH     G  + V LLL     +  +T +G +PL +AAQ    +    LL H A  +
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 419
            V  D    LH AA  G     +LLLD  A  +A+   G+TPLH+A + N   V  LLV 
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 420 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 479
             A        G TP+HVAA+ GH+++V LL   GA  D       T LH+A   G+V  
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 480 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 539
           ++ LL++GA+ DA  +    PLH A+  GK  I ++LL++ A  +  T  G+TPLH++A 
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602

Query: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
           +G +++  +L E+ A         +TPLH+AA++G   V   LLQ  A  ++A ++G TP
Sbjct: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 600 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659
           LH+A         + LLE  A+ HA  K G+TP H+AA K    I   L+  GA+ ++  
Sbjct: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722

Query: 660 KQGVTPLHLASQEGHTDMVTLLLDKGANI 688
               TPL LA +     +++ L  K  ++
Sbjct: 723 GVSCTPLQLALRSRKQGIMSFLEGKEPSV 751



 Score =  210 bits (535), Expect = 2e-53
 Identities = 134/399 (33%), Positives = 196/399 (49%), Gaps = 2/399 (0%)

Query: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
           +T LH     G     +LLL    + + +  +G+TPL IA +  +  +  LL+ +GA   
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
            + E G  P+H AA  G      LLL +GA  D     G T LH+AA+     V R L+ 
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
             A  +    E +TPLH+A+  G   +V+LL    A  DA   N  TPLH++   G+V  
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
              LL++GA      + G+ PLH AA  G   + K+LL+  A+ +     G TPLH+AA+
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602

Query: 606 YDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665
             + ++  LL E  A+  A     +TPLH+AA+  +  + S LL  GA+ N   + G TP
Sbjct: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 725
           LHLA Q      V  LL+  AN+H   K G T  HLAA +    +  +L + GA  D   
Sbjct: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722

Query: 726 KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
            +  TPL +A       +++FL  +G   +  T  G  P
Sbjct: 723 GVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759



 Score =  209 bits (532), Expect = 4e-53
 Identities = 144/439 (32%), Positives = 211/439 (48%), Gaps = 39/439 (8%)

Query: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
           +N  TPL+    +  ++ V+ LL +  +    T  G+TPL +A Q       A+LL    
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA--- 416

Query: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
                                       H AD       NR  E G+ PLH AA  G+  
Sbjct: 417 ----------------------------HGADA------NRVDEDGWAPLHFAAQNGDDG 442

Query: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
            A LLL+ GA VD   R G TPLH+A++    N+ +LL+ R    +    +G TPLH AA
Sbjct: 443 TARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAA 502

Query: 308 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367
             GH  +V+LL  +GA L A+ +N  +PLH+A +   V  ++HLL+  A  D +      
Sbjct: 503 YFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYG 562

Query: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
            LH AA  G Y + K+LL   A+       G+TPLH+A  K  ++++ LL +  A++ A+
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622

Query: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
                TP+H+AA  G   +V  LLQ GA P+     G T LH+A +      V  LL + 
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682

Query: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 547
           A V AR +   TP H+A+  G T I+++L++  A  D       TPL ++ R  +  + S
Sbjct: 683 ANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMS 742

Query: 548 VLLEAGAAHSLATKKGFTP 566
            L   G   S+AT  G  P
Sbjct: 743 FL--EGKEPSVATLGGSKP 759



 Score =  208 bits (530), Expect = 7e-53
 Identities = 139/426 (32%), Positives = 210/426 (49%), Gaps = 8/426 (1%)

Query: 376 GHYRVTKLLLDKRAN--PNARAL----NGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
           G+Y    L L  R N  P    L    N  TPLH    +  ++ + LL+ +   +   T 
Sbjct: 334 GNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA 393

Query: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
           SG TP+ +AA     ++  LLL +GA  +  +  G   LH AA+ G     R LL +GA 
Sbjct: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453

Query: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
           VDA+ RE  TPLH+A++     + +LL+   A P+     G TPLH++A  G V +  +L
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513

Query: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
              GA      +   TPLH+A + G +   + LL+  A  D+  ++G  PLH AA     
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573

Query: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
            +  +LL  GAS       G+TPLH+AA K  ++I   L    A    +     TPLHLA
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633

Query: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
           ++ G   +V+ LL  GA+ + + +SG T LHLA Q         L +H A+  A  K+G+
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693

Query: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
           TP  +A   GN  ++  L++ GA ++ +     TPL  A +     I++ L   G +P+ 
Sbjct: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSV 751

Query: 790 TTANGN 795
            T  G+
Sbjct: 752 ATLGGS 757



 Score =  174 bits (442), Expect = 1e-42
 Identities = 107/285 (37%), Positives = 149/285 (52%)

Query: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588
           N  TPLH    +G V+   +LL         T  G+TPL +AA+    D+  LLL   A 
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
           A+   ++G  PLH AA   +   A LLL+ GA   A  + G+TPLH+AA+ N   +A  L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 708
           ++  A+ N+   +G TPLH+A+  GH  +V LL  +GA +    ++  T LHLA +  KV
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
                L K GA  DA  + GY PL  A   G   +   LL+ GA++   T  G+TPLH A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           A +GH  II++L +  A   A  A   T L +A R G  +VV  L
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645



 Score =  166 bits (421), Expect = 3e-40
 Identities = 128/435 (29%), Positives = 210/435 (48%), Gaps = 29/435 (6%)

Query: 2   MNEDAAQK---SDSGEKFNGSSQRRKR----PKKSD--------SNASFLRAARAGNLDK 46
           +NED +Q+   SDSG     + Q   R    P+  +        +   FL A   G++++
Sbjct: 320 VNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQ--GSVEQ 377

Query: 47  VVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASL 106
           V   L   +D++    +G   L +AA++    L   LL  G+  +   + G   LH A+ 
Sbjct: 378 VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQ 437

Query: 107 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
            G     ++L+  GA ++AQ + G+TPL++AAQ N  +V + L+   A+ +    +G TP
Sbjct: 438 NGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497

Query: 167 LAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222
           L VA   GH   V +L     E D + +     LH+A  +   ++   LL        +S
Sbjct: 498 LHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL--------KS 549

Query: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
             + +   +SG+ PLH AA  G   +  +LL  GA+++     G TPLH+A+ +G+  ++
Sbjct: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII 609

Query: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
            LL +    + A      TPLH AAR G + VV  LL+ GA   A  ++G +PLH+A Q 
Sbjct: 610 HLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669

Query: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402
                V +LL+H A V        T  H+AA  G+  + K+L++  A  + +     TPL
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729

Query: 403 HIACKKNRIKVMELL 417
            +A +  +  +M  L
Sbjct: 730 QLALRSRKQGIMSFL 744



 Score =  141 bits (355), Expect = 1e-32
 Identities = 85/215 (39%), Positives = 116/215 (53%), Gaps = 4/215 (1%)

Query: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
           +N +TPLH      + +   LLL           +GYTPL IAA+  Q  + + LL +GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
           + N V + G  PLH A+Q G      LLLD GA +    + G T LHLAAQ +  NVA +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
           L    AD + H   G TPL VA ++G+V +V  L  QGA ++A+ +N  TPLH A ++G 
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 774 THIINVLLQHGAKPNATTANG----NTALAIAKRL 804
              I  LL+ GA P+A   +G    +TA A  K L
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574



 Score =  137 bits (346), Expect = 2e-31
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 15/305 (4%)

Query: 36  LRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94
           L  A   N + V   L     D N     G   LH+AA  GHV LV+ L  +G+ +D+  
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524

Query: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
           +   T LH+A   G+   ++ L+K GA  +A  Q+G+ PL+ AA      + K LL  GA
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584

Query: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAAL 210
           +    T  G+TPL +A  +GH + + +L E+       G V    LH+AAR  +    + 
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644

Query: 211 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270
           LLQ    AD       N   +SG+TPLH+A           LL   A V    + G TP 
Sbjct: 645 LLQ--CGAD------PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696

Query: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
           H+A+ +GNT ++K+L++ G Q+D +     TPL  A RS   Q +   LE   P +A T 
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS-RKQGIMSFLEGKEPSVA-TL 754

Query: 331 NGLSP 335
            G  P
Sbjct: 755 GGSKP 759



 Score =  100 bits (250), Expect = 2e-20
 Identities = 60/187 (32%), Positives = 90/187 (48%)

Query: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
           +N  TPLH    +  ++    LL +  + +  T  G TPL +A+Q+   D+  LLL  GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
           + +   + G   LH AAQ      A +L  HGA  DA  + G+TPL +A       +   
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
           L+ + A+ N     G TPLH AA  GH  ++ +L   GA+ +A   N  T L +A   G 
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 807 ISVVDTL 813
           +  +  L
Sbjct: 540 VRAIQHL 546


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  209 bits (531), Expect = 6e-53
 Identities = 170/571 (29%), Positives = 269/571 (47%), Gaps = 58/571 (10%)

Query: 68  LHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
           +H AA  G  G +Q L+ G  +  D   + G T L    LA + +    L+K GA++N  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL--- 183
             +  T L++AAQ+ +   +K LL   AN      +  TPL +  +    + +A+LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 184 ---ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
              E DT+ K +  ALH +A  ++ +   LL+++D N  +            G  PLH A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV--------EGKIPLHWA 189

Query: 241 AHYGN---VNVATLLLNRG---AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
           A++ +   V+    +L+     + +++    G TPLH A   GN  +V +L       + 
Sbjct: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNI 248

Query: 295 KTRDGL--TPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHL 351
            + D L  TPLH AA  GH Q+V LLLER  +  +     G +PLH AAQ +  E VK  
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308

Query: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
           L+H +  DD  L+  T+   AA  G   V + +L  +++ +                   
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID------------------- 349

Query: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
             + +  KYG           T +H AA  GH++ V LLL+N A  D T++   T L  A
Sbjct: 350 --INMADKYGG----------TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397

Query: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
              G  +V++ L++ GA VD   ++  + LH A+  G  ++ Q+L+++  +P+     G 
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457

Query: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
           TPL  +A  G ++  +VL+E  A  ++  K+G T LH +   G LD  KLLL   A  + 
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517

Query: 592 AGKN--GLTPLHVAAHYDNQKVALLLLEKGA 620
              N    TPL  A   +  +V   +LE GA
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  193 bits (491), Expect = 2e-48
 Identities = 145/504 (28%), Positives = 238/504 (47%), Gaps = 13/504 (2%)

Query: 303 LHCAARSGHDQVVELLLERGAPLLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361
           +H AA +G    ++ L+   + L  +    G +PL      D ++C   LL+  A V+  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
                TALH+AA  G+YR  KLLL +RAN   + L   TPLH+  +    K + LL+K+ 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 422 ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR---AGQ 476
           A  +  T+  +  T +H +A+  +   V LL+++ ++  + ++ G+  LH AA       
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 477 VEVVRCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY-T 532
           V  VRC+L      +L++ +  E +TPLH A   G   +V +L  + +    +  N + T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 533 PLHISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
           PLH +A  G   +  +LLE   + ++ +  +G TPLH AA+    +  K+ L+  +  D 
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 592 AGKNGLTPLHVAAHYDNQKV--ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
           +   G T    AA   +  V   +L L+     +   K G T LH AA    +     LL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 709
              A+ +       TPL  A + GH D++  L+  GA + +  + G + LH AA     +
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
           V  IL ++  + +     G TPL  A + G +  +  L++  A+ N + K G T LH + 
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497

Query: 770 QQGHTHIINVLLQHGAKPNATTAN 793
             G+   I +LL   A PN    N
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENN 521



 Score =  172 bits (436), Expect = 6e-42
 Identities = 151/543 (27%), Positives = 250/543 (46%), Gaps = 25/543 (4%)

Query: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
           +Q G   L        +     LL  G+ V+       TALH+A+  G    +K+L+   
Sbjct: 45  DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN--QA 178
           AN   +     TPL++  +      +  LL+  A     T+D     A+     +N  + 
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164

Query: 179 VAILLENDT-------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
           V +L+++D+       +GK+    LH AA   D  +   +      A  +S  ++N    
Sbjct: 165 VKLLIKHDSNIGIPDVEGKI---PLHWAANHKDPSAVHTVRCILDAAPTES--LLNWQDY 219

Query: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDR- 288
            G TPLH A   GNV V  +L +   + + T+ + +  TPLH A+  G+  +V LLL+R 
Sbjct: 220 EGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN 278

Query: 289 -GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
             G I + ++ G TPLH AA+S   + V++ L+  +        G +    AA     + 
Sbjct: 279 KSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337

Query: 348 VKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
           ++ +L  K+ +D    D    TALH AA  GH    KLLL+  A  +A  +   TPL  A
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397

Query: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 465
           C+     V++ L+K GA +  + + G + +H AA  G+ ++  +L++N  +P+V +  G 
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457

Query: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
           T L  AA  G +  +  L+ N A  + + +E +T LH +   G  + ++LLL   A P+ 
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517

Query: 526 ATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
              N   YTPL  +    + +V   +LE GA  S+A  +      + A Y    V K   
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGAL-SIAAIQDIAAFKIQAVYKGYKVRKAFR 576

Query: 584 QRR 586
            R+
Sbjct: 577 DRK 579



 Score =  162 bits (410), Expect = 6e-39
 Identities = 131/458 (28%), Positives = 217/458 (47%), Gaps = 13/458 (2%)

Query: 369 LHVAAHCGHY-RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
           +H AA  G    + +L++   A  +     G TPL      +R+   + L+K GA +   
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
             S  T +H+AA  G+   + LLL   A+    ++   T LH+  R    + +  LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 488 AL--VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE---GQ 542
           A   VD + + +QT LH ++     E V+LL++H ++       G  PLH +A       
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 543 VDVASVLLEAGAAHSLAT---KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-T 598
           V     +L+A    SL      +G TPLH A   G++ V  +L    +   ++  N   T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKN-GYTPLHIAAKKNQMQIASTLLNYGAETNI 657
           PLH AA   + ++  LLLE+  S    + + G TPLH AA+ N  +     L + +  + 
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 658 VTKQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILT 715
              +G T    A+ +G  D++  +L      +I+M+ K G T+LH AA    V+   +L 
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 716 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 775
           ++ A  DA   + +TPL  AC  G+  ++  L+K GA V+   ++G++ LH AA  G+  
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 776 IINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           +  +L+++   PN     G T L  A   GYI+ +  L
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475



 Score =  161 bits (408), Expect = 1e-38
 Identities = 162/589 (27%), Positives = 260/589 (44%), Gaps = 61/589 (10%)

Query: 81  QELLGRGSSVDSATKKGNTALHIASLAG-QAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 139
           + LL  GSS+ S        +H A++ G +  + +++V   A  + + Q G TPL     
Sbjct: 5   ENLLFAGSSLASQ-------VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57

Query: 140 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 199
            + +D    LL+ GA+ +              +  H+Q  A               LH+A
Sbjct: 58  ADRLDCADALLKAGADVN--------------KTDHSQRTA---------------LHLA 88

Query: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA- 258
           A+K + +   LLL    N        + +  E   TPLH+   + +     LLL   A  
Sbjct: 89  AQKGNYRFMKLLLTRRAN-------WMQKDLEE-MTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 259 -VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
            VD   +N  T LH ++   N   VKLL+     I     +G  PLH AA       V  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200

Query: 318 L--LERGAP----LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--TAL 369
           +  +   AP    L  +   G +PLH A    +V  V  L  +++  +  + D L  T L
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNITSYDNLFRTPL 259

Query: 370 HVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
           H AA  GH ++  LLL++  +    +   G TPLH A + N  + +++ +K+ +      
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 429 ESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
             G T    AA  G  +++  +L L++    ++ +  G TALH AA +G V  V+ LL N
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
            A VDA    + TPL  A  +G  +++Q L++  A  D    +G++ LH +A  G  DV 
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606
            +L+E     ++    G TPL  AA  G ++   +L++  A  +   K G T LH + + 
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499

Query: 607 DNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGA 653
                  LLL+  A P+    N   YTPL  A    + ++   +L +GA
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  151 bits (382), Expect = 1e-35
 Identities = 143/502 (28%), Positives = 218/502 (43%), Gaps = 63/502 (12%)

Query: 41  AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS----------- 89
           A  LD     LK G D+N  + +   ALHLAA++G+   ++ LL R ++           
Sbjct: 58  ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117

Query: 90  ------------------------VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
                                   VD+  K   TALH ++     E VK+L+K  +NI  
Sbjct: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177

Query: 126 QSQNGFTPLYMAAQENHID-----VVKYLLENGANQSTAT---EDGFTPLAVALQQGHNQ 177
               G  PL+ AA  NH D      V+ +L+    +S       +G TPL  A+  G+  
Sbjct: 178 PDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVT 235

Query: 178 AVAILLENDT------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
            V +L   ++          R P LH AA     +   LLL+ + +  + S         
Sbjct: 236 VVDVLTSYESCNITSYDNLFRTP-LHWAALLGHAQIVHLLLERNKSGTIPS-------DS 287

Query: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
            G TPLH AA         + L   +  D +   G T    A+ +G+ ++++ +L     
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 292 IDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
           ID    D  G T LH AA SGH   V+LLLE  A + A      +PL  A +  H + ++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 350 HLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
            L++  A VD V  D  + LH AA  G+  V ++L++ + NPN +   G TPL  A    
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 410 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--VTNIRGETA 467
            I  M +L++  A      + G T +H +   G+L+ + LLL   A P+    N    T 
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527

Query: 468 LHMAARAGQVEVVRCLLRNGAL 489
           L  A    + EV++ +L +GAL
Sbjct: 528 LDYALLGERHEVIQFMLEHGAL 549



 Score =  108 bits (270), Expect = 1e-22
 Identities = 95/333 (28%), Positives = 150/333 (45%), Gaps = 15/333 (4%)

Query: 501 LHIASRLG-KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559
           +H A+  G K  + +L++ + A  D     G TPL       ++D A  LL+AGA  +  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
                T LH+AA+ G+    KLLL RRA         +TPLH+   + + K   LLL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 620 ASPHATA--KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD- 676
           A        KN  T LH +A  N  +    L+ + +   I   +G  PLH A+   H D 
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDP 195

Query: 677 ----MVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLG 728
                V  +LD       ++     G T LH A  +  V V D+LT +   +  ++  L 
Sbjct: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255

Query: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKP 787
            TPL  A   G+ ++V+ LL++  +    + + G TPLH AAQ      + V L+H +  
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315

Query: 788 NATTANGNTALAIAKRLGYISVVDTLKVVTEEV 820
           + +   G T+   A   G   V+ T+  +  ++
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348



 Score = 92.8 bits (229), Expect = 6e-18
 Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 12/234 (5%)

Query: 30  DSNASFLRAARAGNLD--KVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
           +   SF+ AA  G+ D  + +  LK  IDIN  ++ G  ALH AA  GHV  V+ LL   
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380

Query: 88  SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
           + VD+     +T L  A   G  +V++ L+K GA ++   Q+G + L+ AA   + DV +
Sbjct: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440

Query: 148 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKD 203
            L+EN  N +     G TPL  A   G+   +A+L+EN+     + K    ALH +    
Sbjct: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500

Query: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
              +  LLL      D  +        E  +TPL  A       V   +L  GA
Sbjct: 501 YLDAIKLLL------DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 43/163 (26%), Positives = 68/163 (41%), Gaps = 2/163 (1%)

Query: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
           G TPL         D    LL  GA+++ +  S  T+LHLAAQ+       +L    A+ 
Sbjct: 48  GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107

Query: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGA--NVNAKTKNGYTPLHQAAQQGHTHIINV 779
                   TPL +   + + K +  LLK  A   V+ + KN  T LH +A   +   + +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167

Query: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
           L++H +        G   L  A      S V T++ + +   T
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  209 bits (531), Expect = 6e-53
 Identities = 170/571 (29%), Positives = 269/571 (47%), Gaps = 58/571 (10%)

Query: 68  LHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
           +H AA  G  G +Q L+ G  +  D   + G T L    LA + +    L+K GA++N  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL--- 183
             +  T L++AAQ+ +   +K LL   AN      +  TPL +  +    + +A+LL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 184 ---ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
              E DT+ K +  ALH +A  ++ +   LL+++D N  +            G  PLH A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV--------EGKIPLHWA 189

Query: 241 AHYGN---VNVATLLLNRG---AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
           A++ +   V+    +L+     + +++    G TPLH A   GN  +V +L       + 
Sbjct: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNI 248

Query: 295 KTRDGL--TPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHL 351
            + D L  TPLH AA  GH Q+V LLLER  +  +     G +PLH AAQ +  E VK  
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308

Query: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
           L+H +  DD  L+  T+   AA  G   V + +L  +++ +                   
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID------------------- 349

Query: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
             + +  KYG           T +H AA  GH++ V LLL+N A  D T++   T L  A
Sbjct: 350 --INMADKYGG----------TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397

Query: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
              G  +V++ L++ GA VD   ++  + LH A+  G  ++ Q+L+++  +P+     G 
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457

Query: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
           TPL  +A  G ++  +VL+E  A  ++  K+G T LH +   G LD  KLLL   A  + 
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517

Query: 592 AGKN--GLTPLHVAAHYDNQKVALLLLEKGA 620
              N    TPL  A   +  +V   +LE GA
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  193 bits (491), Expect = 2e-48
 Identities = 145/504 (28%), Positives = 238/504 (47%), Gaps = 13/504 (2%)

Query: 303 LHCAARSGHDQVVELLLERGAPLLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361
           +H AA +G    ++ L+   + L  +    G +PL      D ++C   LL+  A V+  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
                TALH+AA  G+YR  KLLL +RAN   + L   TPLH+  +    K + LL+K+ 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 422 ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR---AGQ 476
           A  +  T+  +  T +H +A+  +   V LL+++ ++  + ++ G+  LH AA       
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 477 VEVVRCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY-T 532
           V  VRC+L      +L++ +  E +TPLH A   G   +V +L  + +    +  N + T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 533 PLHISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
           PLH +A  G   +  +LLE   + ++ +  +G TPLH AA+    +  K+ L+  +  D 
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 592 AGKNGLTPLHVAAHYDNQKV--ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
           +   G T    AA   +  V   +L L+     +   K G T LH AA    +     LL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 709
              A+ +       TPL  A + GH D++  L+  GA + +  + G + LH AA     +
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
           V  IL ++  + +     G TPL  A + G +  +  L++  A+ N + K G T LH + 
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497

Query: 770 QQGHTHIINVLLQHGAKPNATTAN 793
             G+   I +LL   A PN    N
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENN 521



 Score =  172 bits (436), Expect = 6e-42
 Identities = 151/543 (27%), Positives = 250/543 (46%), Gaps = 25/543 (4%)

Query: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
           +Q G   L        +     LL  G+ V+       TALH+A+  G    +K+L+   
Sbjct: 45  DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104

Query: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN--QA 178
           AN   +     TPL++  +      +  LL+  A     T+D     A+     +N  + 
Sbjct: 105 ANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEH 164

Query: 179 VAILLENDT-------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
           V +L+++D+       +GK+    LH AA   D  +   +      A  +S  ++N    
Sbjct: 165 VKLLIKHDSNIGIPDVEGKI---PLHWAANHKDPSAVHTVRCILDAAPTES--LLNWQDY 219

Query: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDR- 288
            G TPLH A   GNV V  +L +   + + T+ + +  TPLH A+  G+  +V LLL+R 
Sbjct: 220 EGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN 278

Query: 289 -GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
             G I + ++ G TPLH AA+S   + V++ L+  +        G +    AA     + 
Sbjct: 279 KSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337

Query: 348 VKHLLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
           ++ +L  K+ +D    D    TALH AA  GH    KLLL+  A  +A  +   TPL  A
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRA 397

Query: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 465
           C+     V++ L+K GA +  + + G + +H AA  G+ ++  +L++N  +P+V +  G 
Sbjct: 398 CEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR 457

Query: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
           T L  AA  G +  +  L+ N A  + + +E +T LH +   G  + ++LLL   A P+ 
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517

Query: 526 ATTN--GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
              N   YTPL  +    + +V   +LE GA  S+A  +      + A Y    V K   
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGAL-SIAAIQDIAAFKIQAVYKGYKVRKAFR 576

Query: 584 QRR 586
            R+
Sbjct: 577 DRK 579



 Score =  162 bits (410), Expect = 6e-39
 Identities = 131/458 (28%), Positives = 217/458 (47%), Gaps = 13/458 (2%)

Query: 369 LHVAAHCGHY-RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
           +H AA  G    + +L++   A  +     G TPL      +R+   + L+K GA +   
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
             S  T +H+AA  G+   + LLL   A+    ++   T LH+  R    + +  LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 488 AL--VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE---GQ 542
           A   VD + + +QT LH ++     E V+LL++H ++       G  PLH +A       
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 543 VDVASVLLEAGAAHSLAT---KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-T 598
           V     +L+A    SL      +G TPLH A   G++ V  +L    +   ++  N   T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKN-GYTPLHIAAKKNQMQIASTLLNYGAETNI 657
           PLH AA   + ++  LLLE+  S    + + G TPLH AA+ N  +     L + +  + 
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 658 VTKQGVTPLHLASQEGHTDMVTLLLD--KGANIHMSTKSGLTSLHLAAQEDKVNVADILT 715
              +G T    A+ +G  D++  +L      +I+M+ K G T+LH AA    V+   +L 
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 716 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 775
           ++ A  DA   + +TPL  AC  G+  ++  L+K GA V+   ++G++ LH AA  G+  
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 776 IINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           +  +L+++   PN     G T L  A   GYI+ +  L
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475



 Score =  161 bits (408), Expect = 1e-38
 Identities = 162/589 (27%), Positives = 260/589 (44%), Gaps = 61/589 (10%)

Query: 81  QELLGRGSSVDSATKKGNTALHIASLAG-QAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 139
           + LL  GSS+ S        +H A++ G +  + +++V   A  + + Q G TPL     
Sbjct: 5   ENLLFAGSSLASQ-------VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57

Query: 140 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 199
            + +D    LL+ GA+ +              +  H+Q  A               LH+A
Sbjct: 58  ADRLDCADALLKAGADVN--------------KTDHSQRTA---------------LHLA 88

Query: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA- 258
           A+K + +   LLL    N        + +  E   TPLH+   + +     LLL   A  
Sbjct: 89  AQKGNYRFMKLLLTRRAN-------WMQKDLEE-MTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 259 -VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
            VD   +N  T LH ++   N   VKLL+     I     +G  PLH AA       V  
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200

Query: 318 L--LERGAP----LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL--TAL 369
           +  +   AP    L  +   G +PLH A    +V  V  L  +++  +  + D L  T L
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYES-CNITSYDNLFRTPL 259

Query: 370 HVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
           H AA  GH ++  LLL++  +    +   G TPLH A + N  + +++ +K+ +      
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 429 ESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
             G T    AA  G  +++  +L L++    ++ +  G TALH AA +G V  V+ LL N
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
            A VDA    + TPL  A  +G  +++Q L++  A  D    +G++ LH +A  G  DV 
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606
            +L+E     ++    G TPL  AA  G ++   +L++  A  +   K G T LH + + 
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499

Query: 607 DNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGA 653
                  LLL+  A P+    N   YTPL  A    + ++   +L +GA
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  151 bits (382), Expect = 1e-35
 Identities = 143/502 (28%), Positives = 218/502 (43%), Gaps = 63/502 (12%)

Query: 41  AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS----------- 89
           A  LD     LK G D+N  + +   ALHLAA++G+   ++ LL R ++           
Sbjct: 58  ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117

Query: 90  ------------------------VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
                                   VD+  K   TALH ++     E VK+L+K  +NI  
Sbjct: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177

Query: 126 QSQNGFTPLYMAAQENHID-----VVKYLLENGANQSTAT---EDGFTPLAVALQQGHNQ 177
               G  PL+ AA  NH D      V+ +L+    +S       +G TPL  A+  G+  
Sbjct: 178 PDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVT 235

Query: 178 AVAILLENDT------KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
            V +L   ++          R P LH AA     +   LLL+ + +  + S         
Sbjct: 236 VVDVLTSYESCNITSYDNLFRTP-LHWAALLGHAQIVHLLLERNKSGTIPS-------DS 287

Query: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
            G TPLH AA         + L   +  D +   G T    A+ +G+ ++++ +L     
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 292 IDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
           ID    D  G T LH AA SGH   V+LLLE  A + A      +PL  A +  H + ++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 350 HLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
            L++  A VD V  D  + LH AA  G+  V ++L++ + NPN +   G TPL  A    
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 410 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--VTNIRGETA 467
            I  M +L++  A      + G T +H +   G+L+ + LLL   A P+    N    T 
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527

Query: 468 LHMAARAGQVEVVRCLLRNGAL 489
           L  A    + EV++ +L +GAL
Sbjct: 528 LDYALLGERHEVIQFMLEHGAL 549



 Score =  108 bits (270), Expect = 1e-22
 Identities = 95/333 (28%), Positives = 150/333 (45%), Gaps = 15/333 (4%)

Query: 501 LHIASRLG-KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559
           +H A+  G K  + +L++ + A  D     G TPL       ++D A  LL+AGA  +  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
                T LH+AA+ G+    KLLL RRA         +TPLH+   + + K   LLL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 620 ASPHATA--KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD- 676
           A        KN  T LH +A  N  +    L+ + +   I   +G  PLH A+   H D 
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDP 195

Query: 677 ----MVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLG 728
                V  +LD       ++     G T LH A  +  V V D+LT +   +  ++  L 
Sbjct: 196 SAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255

Query: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKP 787
            TPL  A   G+ ++V+ LL++  +    + + G TPLH AAQ      + V L+H +  
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315

Query: 788 NATTANGNTALAIAKRLGYISVVDTLKVVTEEV 820
           + +   G T+   A   G   V+ T+  +  ++
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348



 Score = 92.8 bits (229), Expect = 6e-18
 Identities = 73/234 (31%), Positives = 108/234 (46%), Gaps = 12/234 (5%)

Query: 30  DSNASFLRAARAGNLD--KVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
           +   SF+ AA  G+ D  + +  LK  IDIN  ++ G  ALH AA  GHV  V+ LL   
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380

Query: 88  SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
           + VD+     +T L  A   G  +V++ L+K GA ++   Q+G + L+ AA   + DV +
Sbjct: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440

Query: 148 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKD 203
            L+EN  N +     G TPL  A   G+   +A+L+EN+     + K    ALH +    
Sbjct: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNG 500

Query: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
              +  LLL      D  +        E  +TPL  A       V   +L  GA
Sbjct: 501 YLDAIKLLL------DFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 43/163 (26%), Positives = 68/163 (41%), Gaps = 2/163 (1%)

Query: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
           G TPL         D    LL  GA+++ +  S  T+LHLAAQ+       +L    A+ 
Sbjct: 48  GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107

Query: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGA--NVNAKTKNGYTPLHQAAQQGHTHIINV 779
                   TPL +   + + K +  LLK  A   V+ + KN  T LH +A   +   + +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167

Query: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
           L++H +        G   L  A      S V T++ + +   T
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPT 210


>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
            [Homo sapiens]
          Length = 1170

 Score =  208 bits (529), Expect = 1e-52
 Identities = 215/837 (25%), Positives = 348/837 (41%), Gaps = 106/837 (12%)

Query: 57   INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
            +N  + NG  AL LA       +   L+   + VD   K G + LH     G       L
Sbjct: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308

Query: 117  VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 164
            +K GA +NA +     TPL++ A    +++  DV+       + LL+ GAN +     G 
Sbjct: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368

Query: 165  TPLAVALQQGHNQAVAILLE--------NDTKGKVR--LPALHIAARK------------ 202
            TPL V++  G+    + LL+         D +G     L   HI                
Sbjct: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428

Query: 203  ------DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
                  D+   AA L+Q   + D          T +G   L  AA  GN   A  L   G
Sbjct: 429  VNGTSFDENSFAARLIQRGSHTDAPD-------TATGNCLLQRAAGAGNEAAALFLATNG 481

Query: 257  AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL---------------- 300
            A V+   + G TPLH A + G  N+   LL +G   + +T + L                
Sbjct: 482  AHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSV 541

Query: 301  ---TPLHCAARSGHDQVVELLLERGAPLLARTKN-------------GLSPLHMAAQGDH 344
               TPLH A    H  VV ++LE+ A  L  T N               + L +A     
Sbjct: 542  HLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGM 601

Query: 345  VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN-ARALNGFTPLH 403
                  LL   A ++D   D  T LH+A      +    LL+ +A+ N +R  +G T L 
Sbjct: 602  HTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQ 661

Query: 404  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463
            +A +     V++ +   GA +    E G  P+ +A      +I   L+++G         
Sbjct: 662  LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG 721

Query: 464  G----ETALHMAARAGQVEVVRCLLRNGALVDA------------RAREEQTPLHIASRL 507
                 +T LH A           L+R+G  V++             AR+ QTPLH+A+  
Sbjct: 722  PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASW 781

Query: 508  GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTP 566
            G  E VQ LL+  A+ +A    G TP+H++       +  +L+     H ++  ++G TP
Sbjct: 782  GLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTP 841

Query: 567  LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
               A  + +   A+ +L+R + AA+     G   LHVA    + +  L L+   A+ ++ 
Sbjct: 842  FACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901

Query: 626  AKNG--YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
             ++    TPLH+A +     I   LL  GA+ N +TK   T LHLA+Q+    + ++LL+
Sbjct: 902  VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLE 961

Query: 684  KGANIHMSTKSGLTSLHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYG--N 740
             G +     ++G  +LHLA    ++ N+  +LT+   D +A    G +PL +   YG  N
Sbjct: 962  NGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKEN 1021

Query: 741  VKMVNFLLKQ---GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
               +  L  +   G  ++    +G T L  A  +G+ ++   +++ GA+       G
Sbjct: 1022 AAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078



 Score =  168 bits (426), Expect = 9e-41
 Identities = 205/787 (26%), Positives = 316/787 (40%), Gaps = 139/787 (17%)

Query: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
           +N    NG   L +A       +   L+ + A+     + G++ L   +Q+G   A   L
Sbjct: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308

Query: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
           ++N       + A  + A++      AL     H+ADV S+M                  
Sbjct: 309 IKNGAF----VNAATLGAQETPLHLVALYSSKKHSADVMSEM------------------ 346

Query: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD-RGGQIDAKTRDGLT 301
                +A  LL  GA  +     G TPLHV+   GN  +   LL  +   ++ K  +G T
Sbjct: 347 ---AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGST 403

Query: 302 PLHCAARS---GHDQVVELLLERGAPLLARTK--NGLSPLHMAAQGDHVECVKHLLQHKA 356
            L  A +      DQ V    +   P++  T          +  +G H +         A
Sbjct: 404 ALWLAVQHITVSSDQSVNPFED--VPVVNGTSFDENSFAARLIQRGSHTD---------A 452

Query: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 416
           P D  T + L  L  AA  G+      L    A+ N R   G TPLH AC+     +   
Sbjct: 453 P-DTATGNCL--LQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAE 509

Query: 417 LVKYGASIQAITESGL-------------------TPIHVAAFMGHLNIVLLLLQNGAS- 456
           L++ GA+    TE  L                   TP+H+A    H ++V ++L+  A+ 
Sbjct: 510 LLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA 569

Query: 457 ----------PDVT--NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504
                     PD +  + R +T L +A   G   +   LL +GA ++    + QT LH+A
Sbjct: 570 LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629

Query: 505 SRLGKTEIVQLLLQHMAHPDAATT-NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
            +   ++    LL+H A  + + T +G T L ++ R     V   +   GA  S+  +KG
Sbjct: 630 IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689

Query: 564 FTPLHVAAKYGSLDVAKLLLQRRAAAD--SAGKNGL--TPLHVAAHYDNQKVALLLLEKG 619
             PL +A      D+A  L++    A     G  G   T LH A   +N+  A  L+  G
Sbjct: 690 NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749

Query: 620 ASPHAT------------AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667
              ++             A++G TPLH+AA     +    LL +GA  N    +G TP+H
Sbjct: 750 CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809

Query: 668 LASQEGHTDMVTLLLDKGANIHMSTKS--GLTS--------------------------- 698
           +A    H  ++ LL+    +IH++ +   GLT                            
Sbjct: 810 VAISSQHGVIIQLLVSH-PDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV 868

Query: 699 -------LHLAAQEDKVNVADILTKHGAD-----QDAHTKLGYTPLIVACHYGNVKMVNF 746
                  LH+A Q   +     L    A+     QDA +KL  TPL +A   G+  +V  
Sbjct: 869 DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDA-SKL--TPLHLAVQAGSEIIVRN 925

Query: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
           LL  GA VN  TK+  T LH AAQQ    I +VLL++G    A   NGN AL +A   G 
Sbjct: 926 LLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGR 985

Query: 807 ISVVDTL 813
           ++ +  L
Sbjct: 986 LNNIRVL 992



 Score =  154 bits (390), Expect = 1e-36
 Identities = 178/644 (27%), Positives = 267/644 (41%), Gaps = 76/644 (11%)

Query: 26   PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
            P  +  N    RAA AGN    +     G  +N  N+ G   LH A + G   L  ELL 
Sbjct: 453  PDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ 512

Query: 86   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHI 143
            +G++ +                 Q E    L KE A++   A S +  TPL+MA   NH 
Sbjct: 513  QGANPNL----------------QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHP 556

Query: 144  DVVKYLLENGANQSTATED-------------GFTPLAVALQQGHNQAVAILLE-----N 185
            DVV  +LE  AN   AT +               T L +AL  G +   A LL      N
Sbjct: 557  DVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIN 616

Query: 186  DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
            DT    +   LH+A ++ D+KSA  LL  +H AD+     V+R T+ G T L +A     
Sbjct: 617  DTMSDGQ-TLLHMAIQRQDSKSALFLL--EHQADIN----VSR-TQDGETALQLAIRNQL 668

Query: 246  VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP--- 302
              V   +  RGA +      G  PL +A      ++   L+  G   DA T  G  P   
Sbjct: 669  PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG--CDA-TCWGPGPGGC 725

Query: 303  ----LHCAARSGHDQVVELLLERGAPLLA------------RTKNGLSPLHMAAQGDHVE 346
                LH A    ++     L+  G  + +              ++G +PLH+AA     E
Sbjct: 726  LQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEE 785

Query: 347  CVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD-KRANPNARALNGFTPLHIA 405
             V+ LL+  A V+    +  T +HVA    H  + +LL+     + N R   G TP   A
Sbjct: 786  TVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACA 845

Query: 406  CK-KNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--VTNI 462
               KN      +L +   + + +   G   +HVA     +  VL L+   A+ +  V + 
Sbjct: 846  MTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDA 905

Query: 463  RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
               T LH+A +AG   +VR LL  GA V+   +  QT LH+A++     I  +LL++   
Sbjct: 906  SKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVD 965

Query: 523  PDAATTNGYTPLHISAREGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 581
              A   NG   LH++   G+++   VLL E          +G +PLH+  +YG  + A +
Sbjct: 966  FAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAI 1025

Query: 582  L-----LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
                         D    +G T L +A    N  +   ++  GA
Sbjct: 1026 FDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGA 1069


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  184 bits (467), Expect = 2e-45
 Identities = 129/396 (32%), Positives = 205/396 (51%), Gaps = 3/396 (0%)

Query: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 374
           ++ LLE+   +  R + G +PL +AA+  ++E VK L+++ A  +   LD  TAL  A+ 
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 375 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 434
            GH  + + LL    N   R + G+T L  AC K R  V+ELL+ +GA+        + P
Sbjct: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140

Query: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
           I  AA  GH +IV LLLQNGA  + ++  G T L  AAR G +E V+ LL  GA VD   
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200

Query: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
               T L +A + G T+ V+ +L+   + +    +G T L I+++EG  ++   LL+AG 
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260

Query: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614
             ++  + G T L  A + G +++ + LLQ+ A  D  G++  T L+ A    N  +   
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320

Query: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
           +L+         K+G TPL  A K   +++   LL+ GA+ + V K+G TPLH+A +   
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380

Query: 675 TDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDK 707
             +  LLL     G  ++   K+G T  ++     K
Sbjct: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 416



 Score =  183 bits (465), Expect = 3e-45
 Identities = 123/377 (32%), Positives = 197/377 (52%)

Query: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
           ++  I  ++ L++    +    E G TP+ +AA  G+L IV  L++NGA+ ++ ++   T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 526
           AL  A++ G V +V  LL+ G  ++ R     T L  A   G+T++V+LLL H A+P   
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
                 P+  +A  G  D+  +LL+ GA  + + K G TPL  AA+ G L+  K LL   
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
           A  D  G N +T L VA      +    +L++  + + T K+G T L IA+K+   +I  
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253

Query: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
            LL+ G   NI  + G T L  A + GH ++V  LL K A+I +  +   T+L+ A ++ 
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313

Query: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766
              +   + +   D +  TK G TPLI A    N+++V  LL +GA V+A  K G TPLH
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373

Query: 767 QAAQQGHTHIINVLLQH 783
            A +     +  +LL++
Sbjct: 374 IAIRGRSRKLAELLLRN 390



 Score =  175 bits (443), Expect = 9e-43
 Identities = 127/385 (32%), Positives = 192/385 (49%), Gaps = 12/385 (3%)

Query: 73  KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132
           +E ++  ++ LL +   VD   + G T L IA+  G  E+VK L+K GAN N +  + +T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK---- 188
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G    V +LL +       
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 189 GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNV 248
           G   +  +  AA +       LLLQN           VN + + G TPL  AA  G++  
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAK--------VNCSDKYGTTPLVWAARKGHLEC 185

Query: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
              LL  GA VD    N +T L VA K G T  VK +L R   ++   +DG T L  A++
Sbjct: 186 VKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASK 245

Query: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368
            GH ++V+ LL+ G  +    ++G + L  A +G HVE V+ LLQ  A +D    D  TA
Sbjct: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 305

Query: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
           L+ A   G+  + + +L    +      +G TPL  A K   I+V+ELL+  GA + A+ 
Sbjct: 306 LYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVD 365

Query: 429 ESGLTPIHVAAFMGHLNIVLLLLQN 453
           + G TP+H+A       +  LLL+N
Sbjct: 366 KKGDTPLHIAIRGRSRKLAELLLRN 390



 Score =  167 bits (424), Expect = 1e-40
 Identities = 141/490 (28%), Positives = 214/490 (43%), Gaps = 73/490 (14%)

Query: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI 198
           +E +I  +K LLE   +     E G TPL +A +QG+ + V  L+               
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58

Query: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258
                         +N  N +++            +T L  A+  G+V++   LL  G  
Sbjct: 59  --------------KNGANCNLEDL--------DNWTALISASKEGHVHIVEELLKCGVN 96

Query: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
           ++     G T L  A  +G T++V+LLL  G          + P+  AA  GH  +V LL
Sbjct: 97  LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156

Query: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
           L+ GA +    K G +PL  AA+  H+ECVKHLL   A VD    + +TAL VA   G+ 
Sbjct: 157 LQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYT 216

Query: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
           +  K +L +  N N    +G T L IA K+                              
Sbjct: 217 QSVKEILKRNPNVNLTDKDGNTALMIASKE------------------------------ 246

Query: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498
              GH  IV  LL  G   ++ +  G+T L  A R G VE+VR LL+  A +D R ++ +
Sbjct: 247 ---GHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK 303

Query: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558
           T L+ A   G   +V+ +LQ     +  T +G TPL  + +   ++V  +LL+ GA  S 
Sbjct: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363

Query: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKVALLL 615
             KKG TPLH+A +  S  +A+LLL+            K G TP ++   +    +  + 
Sbjct: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF 423

Query: 616 LEKGASPHAT 625
             +  SP  T
Sbjct: 424 GARHLSPTET 433



 Score =  159 bits (403), Expect = 4e-38
 Identities = 128/403 (31%), Positives = 200/403 (49%), Gaps = 24/403 (5%)

Query: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
           AA  GNL+ V E +K G + N  + +   AL  A+KEGHV +V+ELL  G +++     G
Sbjct: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104

Query: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
            TAL  A   G+ +VV++L+  GAN +        P+  AA   H D+V  LL+NGA  +
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164

Query: 158 TATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
            + + G TPL  A ++GH + V  LL    + D +G   + AL +A +   T+S   +L+
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224

Query: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
            + N        VN T + G T L IA+  G+  +   LL+ G  V+   R+G T L  A
Sbjct: 225 RNPN--------VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGA 276

Query: 274 SKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL 333
            + G+  +V+ LL +   ID + +D  T L+ A   G+  +V  +L+        TK+G 
Sbjct: 277 VRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGE 336

Query: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
           +PL  A +  ++E V+ LL   A V  V     T LH+A      ++ +LLL    NP  
Sbjct: 337 TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL---RNPKD 393

Query: 394 RAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430
             L       G TP +I C   +  + ++   +GA   + TE+
Sbjct: 394 GRLLYRPNKAGETPYNIDCSHQKSILTQI---FGARHLSPTET 433



 Score =  141 bits (355), Expect = 1e-32
 Identities = 110/360 (30%), Positives = 165/360 (45%), Gaps = 33/360 (9%)

Query: 477 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 536
           +  ++ LL     VD R    QTPL IA+  G  EIV+ L+++ A+ +    + +T L  
Sbjct: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77

Query: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
           +++EG V +   LL+ G         G+T L  A   G  DV +LLL   A     G   
Sbjct: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137

Query: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE-- 654
           + P+  AA   +  +  LLL+ GA  + + K G TPL  AA+K  ++    LL  GA+  
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197

Query: 655 -------------------------------TNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
                                           N+  K G T L +AS+EGHT++V  LLD
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257

Query: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
            G  +++  +SG T L  A +   V +   L +  AD D   +   T L  A   GN  M
Sbjct: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317

Query: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803
           V  +L+   +    TK+G TPL +A +  +  ++ +LL  GAK +A    G+T L IA R
Sbjct: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR 377



 Score =  113 bits (282), Expect = 4e-24
 Identities = 73/239 (30%), Positives = 118/239 (49%)

Query: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634
           ++   K LL++    D   + G TPL +AA   N ++   L++ GA+ +    + +T L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
            A+K+  + I   LL  G         G T L  A  +G TD+V LLL  GAN  ++   
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
            +  +  AA     ++  +L ++GA  +   K G TPL+ A   G+++ V  LL  GA+V
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
           + +  N  T L  A + G+T  +  +L+     N T  +GNTAL IA + G+  +V  L
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255



 Score =  101 bits (252), Expect = 1e-20
 Identities = 67/215 (31%), Positives = 115/215 (53%), Gaps = 9/215 (4%)

Query: 29  SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
           ++S  + + A + G    V E LK   ++N  +++G  AL +A+KEGH  +VQ+LL  G+
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260

Query: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
            V+   + G+T L  A   G  E+V+ L+++ A+I+ + Q+  T LY A ++ +  +V+ 
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320

Query: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDD 204
           +L+   +    T+DG TPL  A +  + + V +LL+   K     K     LHIA R   
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380

Query: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
            K A LLL+N  +       ++ R  ++G TP +I
Sbjct: 381 RKLAELLLRNPKDG-----RLLYRPNKAGETPYNI 410



 Score = 95.1 bits (235), Expect = 1e-18
 Identities = 66/236 (27%), Positives = 117/236 (49%), Gaps = 25/236 (10%)

Query: 644 IASTLLNYGAETNIVTKQ---------------GVTPLHLASQEGHTDMVTLLLDKGANI 688
           I+ +++NY  E NI   +               G TPL +A+++G+ ++V  L+  GAN 
Sbjct: 5   ISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANC 64

Query: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
           ++      T+L  A++E  V++ + L K G + +     G+T L+ AC+ G   +V  LL
Sbjct: 65  NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124

Query: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 808
             GAN +        P+  AA +GH  I+++LLQ+GAK N +   G T L  A R G++ 
Sbjct: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184

Query: 809 VVDTLKV----VTEEVTTTTTTITEKHKLNVPETMTEVL------DVSDEEGDDTM 854
            V  L      V +E   + T +    K    +++ E+L      +++D++G+  +
Sbjct: 185 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  180 bits (457), Expect = 2e-44
 Identities = 155/542 (28%), Positives = 258/542 (47%), Gaps = 38/542 (7%)

Query: 57  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVV 113
           +  C+      LH AA EG + L++++  R SS++   +    GNT LH A    Q E V
Sbjct: 56  LKRCDDMDTFFLHYAAAEGQIELMEKIT-RDSSLEVLHEMDDYGNTPLHCAVEKNQIESV 114

Query: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQSTATEDGFTPLAVALQ 172
           K L+  GAN N ++ N   PL++A Q  + +V+K LLE+   + +   E+G T + +A  
Sbjct: 115 KFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACT 174

Query: 173 QGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR 228
             +++A+ ILL+   K     K     +H AA     +   ++L+         ++ +N 
Sbjct: 175 TNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINF 234

Query: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
                 TPLH+A   G++ +  + L+ GA +D   +   T +H A+ +G T +VKL++  
Sbjct: 235 MNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISS 294

Query: 289 -GGQID-AKTRDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
             G +D   T DG   T LH A+   H ++ + L+  GA +      G SPL +A     
Sbjct: 295 YSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASAS 354

Query: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH------------YRVTKLLLDKRANPN 392
              V  LL   A VD         LH+     +             ++ +L++D+     
Sbjct: 355 WNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN--- 411

Query: 393 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
               +G TPLH AC++     +  L+ +  SI + ++   +P+H AA  G +N    LLQ
Sbjct: 412 ----DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 467

Query: 453 NGASPDVTN---IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
           + +   + N   + G T LH+AA+ G  +VV+ LL+ GAL         T LH AS  G 
Sbjct: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGY 526

Query: 510 TEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568
           T+ ++++L  ++   D    +G T LH +AREG     ++LL    A  +  K+  + LH
Sbjct: 527 TQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHN-ADIVLNKQQASFLH 585

Query: 569 VA 570
           +A
Sbjct: 586 LA 587



 Score =  178 bits (451), Expect = 1e-43
 Identities = 152/541 (28%), Positives = 246/541 (45%), Gaps = 60/541 (11%)

Query: 270 LHVASKRGNTNMV-KLLLDRGGQIDAKTRD-GLTPLHCAARSGHDQVVELLLERGAPLLA 327
           LH A+  G   ++ K+  D   ++  +  D G TPLHCA      + V+ LL RGA    
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD---YLTALHVAAHCGHYRVTKLL 384
           R  N ++PLH+A QG + E +K LL+H+    DV L+     TA+ +A    +    ++L
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHR--TIDVNLEGENGNTAVIIACTTNNSEALQIL 184

Query: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS--------IQAITESGLTPIH 436
           L K A P      G  P+H A      + ME+++++G          I  +     TP+H
Sbjct: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244

Query: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA----LVDA 492
           +A   G L ++ + L NGA  D       TA+H AA  G  E+V+ ++ + +    +V+ 
Sbjct: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304

Query: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552
                +T LH AS     E+   L+   A  +   + G +PL ++      ++ ++LL  
Sbjct: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364

Query: 553 GAAHSLATKKGFTPLHVAAK--YGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYD 607
           GA   +    G   LH+  +  YG  ++    +Q +   +       +G TPLH A    
Sbjct: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG 424

Query: 608 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK---QGVT 664
                  LL    S H+ +K+  +PLH AA   ++     LL   ++T ++ +    G+T
Sbjct: 425 GPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484

Query: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724
           PLHLA++ GH  +V LLL KGA + +S  +G T+LH A+                     
Sbjct: 485 PLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMG------------------- 524

Query: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
              GYT  +      N+K  + L           ++G T LH AA++GH   + +LL H 
Sbjct: 525 ---GYTQTMKVILDTNLKCTDRL----------DEDGNTALHFAAREGHAKAVALLLSHN 571

Query: 785 A 785
           A
Sbjct: 572 A 572



 Score =  149 bits (377), Expect = 4e-35
 Identities = 131/488 (26%), Positives = 214/488 (43%), Gaps = 68/488 (13%)

Query: 402 LHIACKKNRIKVMELLVKYGASIQAITES---GLTPIHVAAFMGHLNIVLLLLQNGASPD 458
           LH A  + +I++ME + +  +S++ + E    G TP+H A     +  V  LL  GA+P+
Sbjct: 67  LHYAAAEGQIELMEKITR-DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPN 125

Query: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLL 517
           + N      LH+A +    EV++ LL +  + V+       T + IA     +E +Q+LL
Sbjct: 126 LRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILL 185

Query: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--------TPLHV 569
           +  A P  +   G  P+H +A  G  +   ++L  G  H  + +           TPLH+
Sbjct: 186 KKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245

Query: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK--GASPHATAK 627
           A + G L++ K+ L   A  D   K   T +H AA     ++  L++    G+       
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305

Query: 628 NGY--TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
           +G   T LH A+  +  ++A  L++ GA+ N +  +G +PL LA+     ++V LLL KG
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365

Query: 686 ANIHMSTKSGLTSLHLAAQED--------KVNVADILTKHGADQDAHTKLGYTPLIVACH 737
           A + +    G   LHL  Q+         +      + +   D+D     G TPL  AC 
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDND---GCTPLHYACR 422

Query: 738 YGNVKMVNFLLKQGANVNAKTKN------------------------------------G 761
            G    VN LL    ++++K+K+                                    G
Sbjct: 423 QGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHG 482

Query: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821
            TPLH AA+ GH  ++ +LL+ GA    +  NG TAL  A   GY     T+KV+ +   
Sbjct: 483 MTPLHLAAKNGHDKVVQLLLKKGAL-FLSDHNGWTALHHASMGGY---TQTMKVILDTNL 538

Query: 822 TTTTTITE 829
             T  + E
Sbjct: 539 KCTDRLDE 546



 Score =  140 bits (353), Expect = 3e-32
 Identities = 129/464 (27%), Positives = 214/464 (46%), Gaps = 49/464 (10%)

Query: 55  IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
           ID+N   +NG  A+ +A    +   +Q LL +G+    + K G   +H A+ +G  E ++
Sbjct: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215

Query: 115 VLVKEG--------ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
           ++++ G         +IN  +    TPL++A Q   ++++K  L+NGA      +   T 
Sbjct: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275

Query: 167 LAVALQQGHNQAVAILLEN--------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
           +  A  QG  + V +++ +        +T        LH A+  D  + A  L+     A
Sbjct: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLI--SVGA 333

Query: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR-- 276
           D      +N+    G +PL +A    + N+  LLL++GA VD     G   LH+  ++  
Sbjct: 334 D------INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPY 387

Query: 277 GNTNM----------VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
           G  N+           +L++D       +  DG TPLH A R G    V  LL     + 
Sbjct: 388 GLKNLRPEFMQMQQIKELVMD-------EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIH 440

Query: 327 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAP---VDDVTLDYLTALHVAAHCGHYRVTKL 383
           +++K+  SPLH AA    +   + LLQ  +    +++  L  +T LH+AA  GH +V +L
Sbjct: 441 SKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQL 500

Query: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS-IQAITESGLTPIHVAAFMG 442
           LL K A       NG+T LH A      + M++++         + E G T +H AA  G
Sbjct: 501 LLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREG 559

Query: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
           H   V LLL + A   V N +  + LH+A    + EVV  ++R+
Sbjct: 560 HAKAVALLLSHNAD-IVLNKQQASFLHLALHNKRKEVVLTIIRS 602



 Score =  118 bits (295), Expect = 1e-25
 Identities = 109/365 (29%), Positives = 166/365 (45%), Gaps = 49/365 (13%)

Query: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSA-TK 95
           A + G+L+ +   L  G  I+   +    A+H AA +G   +V+ ++   S SVD   T 
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305

Query: 96  KG--NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
            G   T LH ASL    E+   L+  GA+IN     G +PL +A      ++V  LL  G
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365

Query: 154 ANQSTATEDGFTPLAVALQQGH------------NQAVAILLENDTKGKVRLPALHIAAR 201
           A        G   L + +QQ +             Q   ++++ D  G      LH A R
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDG---CTPLHYACR 422

Query: 202 KDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA---------TLL 252
           +    S   LL    N  + SK      ++   +PLH AA YG +N           T L
Sbjct: 423 QGGPGSVNNLL--GFNVSIHSK------SKDKKSPLHFAASYGRINTCQRLLQDISDTRL 474

Query: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312
           LN G        +G+TPLH+A+K G+  +V+LLL +G  +     +G T LH A+  G+ 
Sbjct: 475 LNEGDL------HGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYT 527

Query: 313 QVVELLLERGAPLLAR-TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA--L 369
           Q ++++L+       R  ++G + LH AA+  H + V  LL H A   D+ L+   A  L
Sbjct: 528 QTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA---DIVLNKQQASFL 584

Query: 370 HVAAH 374
           H+A H
Sbjct: 585 HLALH 589



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 7/118 (5%)

Query: 38  AARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSAT 94
           AA+ G+ DKVV+ L  KG + ++  + NG  ALH A+  G+   ++ +L       D   
Sbjct: 489 AAKNGH-DKVVQLLLKKGALFLS--DHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545

Query: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
           + GNTALH A+  G A+ V +L+   A+I    Q   + L++A      +VV  ++ +
Sbjct: 546 EDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTIIRS 602


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  179 bits (455), Expect = 4e-44
 Identities = 109/326 (33%), Positives = 172/326 (52%), Gaps = 2/326 (0%)

Query: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
           G + LH+A  AGQ E  + LL N A  +   R   TPLH+A       +V+LLL      
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497

Query: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
           +A   + +T LH +A+ G      +LLE  A+ +    +G TP+HVA ++G  ++ ++LL
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557

Query: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQM 642
           +R       GK+   PLH AA   +  +  LL ++ G S +A   +G TPLH+AA++   
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617

Query: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702
           ++A  L++  ++ N+ +    TPLH+A++ GHT    LLL +GA     T  G T+LHLA
Sbjct: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677

Query: 703 AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY 762
           A+   +    +L +  AD  A   L  T L +A  +G+ ++V  L+     ++   + G 
Sbjct: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736

Query: 763 TPLHQAAQQGHTHIINVLLQHGAKPN 788
           + LH AAQ  H   +  LL+HGA  N
Sbjct: 737 SALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  178 bits (451), Expect = 1e-43
 Identities = 117/335 (34%), Positives = 176/335 (52%), Gaps = 3/335 (0%)

Query: 360 DVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418
           D+ LD   + LH+A   G     K LL   ANPN     G TPLH+A ++    V+ELL+
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491

Query: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
               S+ A  E   T +H AA  G  +   LLL+  AS +  +  G T +H+A + GQ  
Sbjct: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551

Query: 479 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL-QHMAHPDAATTNGYTPLHIS 537
           +VR LLR G  V  + ++   PLH A+  G   IV+LL  Q     +A T +G TPLH++
Sbjct: 552 IVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611

Query: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
           A+ G   VA +L++  +  ++ +    TPLHVAA+ G    A+LLL R A  ++   +G 
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671

Query: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
           T LH+AA   +     LL+E+ A   A      T LH+AA     ++   L++     ++
Sbjct: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDL 730

Query: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST 692
             +QG++ LHLA+Q  H   V  LL  GA+I++ +
Sbjct: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765



 Score =  172 bits (435), Expect = 8e-42
 Identities = 115/345 (33%), Positives = 176/345 (51%), Gaps = 3/345 (0%)

Query: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
           G+T+ +  +L +   +D     G + LH A  +G ++  + LL   A      + G +PL
Sbjct: 417 GDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475

Query: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
           HMA +      V+ LL  K  V+    D  TALH AA  G    T+LLL+K A+ N    
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535

Query: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGA 455
            G TP+H+AC+  +  ++ +L++ G  +    +    P+H AA+ GHL IV LL  Q G 
Sbjct: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595

Query: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
           S +   + G T LH+AA+ G   V R L+   + V+  +   QTPLH+A+  G T   +L
Sbjct: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARL 655

Query: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
           LL   A  +A T++GYT LH++AR G +    +L+E  A          T LH+AA +G 
Sbjct: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH 715

Query: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
            +V + L+      D   + GL+ LH+AA   + +    LL  GA
Sbjct: 716 SEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  168 bits (426), Expect = 9e-41
 Identities = 116/358 (32%), Positives = 183/358 (51%), Gaps = 9/358 (2%)

Query: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
           K+M++L      +    +SG + +H+A   G       LL N A+P+++N RG T LHMA
Sbjct: 421 KLMKILQPQ--DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478

Query: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY 531
                  VV  LL     V+A+  ++ T LH A++ G     +LLL+  A  +     G 
Sbjct: 479 VERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR 538

Query: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
           TP+H++ + GQ ++  +LL  G   SL  K  + PLH AA  G L + KLL ++   + +
Sbjct: 539 TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVN 598

Query: 592 AGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
           A   +G TPLH+AA   + +VA +L++  +  +  +    TPLH+AA+      A  LL+
Sbjct: 599 AQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLH 658

Query: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
            GA    +T  G T LHLA++ GH   V LL+++ A++        T+LHLAA      V
Sbjct: 659 RGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEV 718

Query: 711 ADILTKHGADQ-DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN---AKTKNGYTP 764
            + L    AD  D   + G + L +A    + + V  LL+ GA++N    K + G+ P
Sbjct: 719 VEELV--SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774



 Score =  168 bits (425), Expect = 1e-40
 Identities = 120/360 (33%), Positives = 189/360 (52%), Gaps = 13/360 (3%)

Query: 41  AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
           +G+  K+++ L+   D++    +G + LHLA + G     + LL   ++ + + ++G+T 
Sbjct: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474

Query: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
           LH+A       VV++L+    ++NA+ ++ +T L+ AAQ       + LLE  A+ +   
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534

Query: 161 EDGFTPLAVALQQGHNQAVAILLENDT----KGKVRLPALHIAARKDDTKSAALLLQNDH 216
            +G TP+ VA Q G    V ILL        +GK     LH AA +       LL +   
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK--- 591

Query: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
               Q  + VN  T  G TPLH+AA  G+  VA +L++  + V+  +    TPLHVA++ 
Sbjct: 592 ----QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAET 647

Query: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
           G+T+  +LLL RG   +A T DG T LH AAR+GH   V+LL+E  A +LAR     + L
Sbjct: 648 GHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTAL 707

Query: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
           H+AA   H E V+ L+     +D      L+ALH+AA   H +  + LL   A+ N ++L
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score =  157 bits (397), Expect = 2e-37
 Identities = 103/330 (31%), Positives = 163/330 (49%), Gaps = 2/330 (0%)

Query: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
           VD    +G + LH+A + G     K LL      +   R G TPLH A       VVELL
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
           L R   + A+ ++  + LH AAQ       + LL+  A V++V  +  T +HVA   G  
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASIQAITESGLTPIHV 437
            + ++LL +  + + +  + + PLH A  +  + +++LL K  G S+ A T  G TP+H+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610

Query: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
           AA  GH  +  +L+   +  +V ++  +T LH+AA  G     R LL  GA  +A   + 
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
            T LH+A+R G    V+LL++  A   A      T LH++A  G  +V   L+ A     
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI-D 729

Query: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
           L  ++G + LH+AA+       + LL+  A
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  156 bits (395), Expect = 3e-37
 Identities = 96/314 (30%), Positives = 160/314 (50%), Gaps = 2/314 (0%)

Query: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
           LH+A   G+ E  + LL + A+P+ +   G TPLH++       V  +LL    + +   
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501

Query: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
           +  +T LH AA+ G     +LLL++ A+ +     G TP+HVA  +  + +  +LL +G 
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561

Query: 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVT 679
                 K+ + PLH AA +  + I   L    G   N  T  G TPLHLA+Q GH  +  
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621

Query: 680 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 739
           +L+D  +++++ +    T LH+AA+    + A +L   GA ++A T  GYT L +A   G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681

Query: 740 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
           ++  V  L+++ A+V A+     T LH AA  GH+ ++  L+      +     G +AL 
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740

Query: 800 IAKRLGYISVVDTL 813
           +A +  +   V+TL
Sbjct: 741 LAAQGRHAQTVETL 754



 Score =  108 bits (270), Expect = 1e-22
 Identities = 81/276 (29%), Positives = 136/276 (49%), Gaps = 16/276 (5%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           K  D   +   AA+ G+       L+    +N  +  G   +H+A + G   +V+ LL R
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNGFTPLYMAAQENHIDV 145
           G  V    K     LH A+  G   +VK+L K+ G ++NAQ+ +G TPL++AAQ  H  V
Sbjct: 560 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619

Query: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL-----PALHIAA 200
            + L++  ++ +  +    TPL VA + GH     +LL     GK  +      ALH+AA
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA-GKEAMTSDGYTALHLAA 678

Query: 201 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
           R     +  LL+  +  ADV ++  +N+T       LH+AA +G+  V   L++    +D
Sbjct: 679 RNGHLATVKLLV--EEKADVLARGPLNQTA------LHLAAAHGHSEVVEELVS-ADVID 729

Query: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
                G++ LH+A++  +   V+ LL  G  I+ ++
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765



 Score =  108 bits (269), Expect = 1e-22
 Identities = 74/234 (31%), Positives = 116/234 (49%), Gaps = 3/234 (1%)

Query: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
           +G + LH+A +  Q + A  LL   A  N+  ++G TPLH+A +     +V LLL +  +
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496

Query: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
           ++   +   T+LH AAQ    +   +L +  A  +     G TP+ VAC +G   +V  L
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556

Query: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 806
           L++G +V+ + K+ + PLH AA QGH  I+ +L  Q G   NA T +G T L +A + G+
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616

Query: 807 ISVVDTLKVVTEEVTTTTTTI-TEKH-KLNVPETMTEVLDVSDEEGDDTMTGDG 858
             V   L  +  +V   +    T  H       T T  L +    G + MT DG
Sbjct: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670



 Score = 70.5 bits (171), Expect = 3e-11
 Identities = 44/160 (27%), Positives = 74/160 (46%)

Query: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
           + ++    G + LHLA + G  +    LL   AN ++S + G T LH+A +     V ++
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489

Query: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
           L       +A  +  +T L  A   G+      LL++ A+VN     G TP+H A Q G 
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549

Query: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
            +I+ +LL+ G   +    +    L  A   G++ +V  L
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589



 Score = 56.2 bits (134), Expect = 6e-07
 Identities = 39/113 (34%), Positives = 58/113 (51%), Gaps = 4/113 (3%)

Query: 24  KRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL 83
           K    SD   +   AAR G+L  V   ++   D+         ALHLAA  GH  +V+EL
Sbjct: 663 KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722

Query: 84  LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS---QNGFTP 133
           +     +D   ++G +ALH+A+    A+ V+ L++ GA+IN QS   Q G  P
Sbjct: 723 VS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  173 bits (438), Expect = 3e-42
 Identities = 124/333 (37%), Positives = 166/333 (49%), Gaps = 11/333 (3%)

Query: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
           G+  L  A   G   + T LL +GA+V+     G TPLH+A  RG+  +V+LLL RG  +
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352
            A  R G T LH AA  GH +V ELLL+RGA   AR+  GL+PLH AA   H      LL
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160

Query: 353 QHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408
           +   P     +       TA H AA  G   V +LL           L+G   L +A   
Sbjct: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-----AGGAGLDG--ALLVAAAA 213

Query: 409 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
            R   +  L+  GA + A   +G T + +AA +G    + +LL +GA P + +  G +AL
Sbjct: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273

Query: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
           H AA  G +  V+ L+  GA VDAR     TPLH ASR G  E+   LL   A  DA   
Sbjct: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333

Query: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATK 561
              TPLH++A  G      +LL  GA+ +L T+
Sbjct: 334 LRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366



 Score =  163 bits (412), Expect = 4e-39
 Identities = 120/313 (38%), Positives = 161/313 (51%), Gaps = 11/313 (3%)

Query: 314 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373
           +V  LL +GA +  R   G +PLH+A    H   V+ LLQ  APV  V     TALH AA
Sbjct: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115

Query: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNRIKVMELLVKYG---ASIQAITE 429
             GH RV +LLL + A+  AR+  G TPLH  A   + +    LL   G   A+ +A   
Sbjct: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDA 175

Query: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
            G T  H AA  G L ++ LL   GA  D        AL +AA AG+   +R LL  GA 
Sbjct: 176 RGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGAR 228

Query: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
           VDAR     T L +A+ LG+++ +++LL H A P     +G + LH +A  G +    +L
Sbjct: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288

Query: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
           +  GA        G TPLH A++ G ++VA  LL R A  D+ G    TPLH+AA   + 
Sbjct: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348

Query: 610 KVALLLLEKGASP 622
               LLL +GASP
Sbjct: 349 PTVGLLLSRGASP 361



 Score =  155 bits (392), Expect = 8e-37
 Identities = 121/326 (37%), Positives = 161/326 (49%), Gaps = 11/326 (3%)

Query: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
           A + G   +V  LL+ GAS +  +  G T LH+A   G   +VR LL+ GA V A  R  
Sbjct: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107

Query: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG---- 553
           +T LH A+  G + + +LLLQ  A   A +  G TPLH +A  G   +A+ LLEA     
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167

Query: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
           AA      +G+T  H AA  G L V +LL     AA  AG +G   L VAA         
Sbjct: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL-----AAGGAGLDGA--LLVAAAAGRGAALR 220

Query: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673
            LL +GA   A    G T L +AA   + Q    LL +GA+  I  + G + LH A+  G
Sbjct: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280

Query: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 733
           H   V LL+ +GA +      GLT LH A++E  V VA  L   GA  DA   L  TPL 
Sbjct: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340

Query: 734 VACHYGNVKMVNFLLKQGANVNAKTK 759
           +A   G+   V  LL +GA+   +T+
Sbjct: 341 LAAERGHGPTVGLLLSRGASPTLRTQ 366



 Score =  152 bits (383), Expect = 8e-36
 Identities = 118/335 (35%), Positives = 160/335 (47%), Gaps = 15/335 (4%)

Query: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
           G   L  A   G  GLV +LL +G+SV+     G T LH+A L G A +V++L++ GA +
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
            A  + G T L+ AA   H  V + LL+ GA+ +  +  G TPL  A   GH    A LL
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160

Query: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLH----I 239
           E    G    PA   AA  +D +         H A    ++ V     +G   L     +
Sbjct: 161 EAPGPG----PA---AAEAEDARGWTAA----HWAAAGGRLAVLELLAAGGAGLDGALLV 209

Query: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
           AA  G       LL RGA VD     G T L +A+  G +  +++LL  G     + R G
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHG 269

Query: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
            + LH AA  GH   V+LL+ +GA + AR   GL+PLH A++  HVE    LL   A VD
Sbjct: 270 RSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVD 329

Query: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394
                  T LH+AA  GH     LLL + A+P  R
Sbjct: 330 ATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLR 364



 Score =  138 bits (348), Expect = 1e-31
 Identities = 105/341 (30%), Positives = 162/341 (47%), Gaps = 13/341 (3%)

Query: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567
           G   +V  LL+  A  +     G TPLH++   G   +  +LL+ GA      + G T L
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111

Query: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627
           H AA +G   VA+LLLQR A+A +    GLTPLH AA   +  +A  LLE      A A+
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171

Query: 628 ----NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
                G+T  H AA   ++ +   L   GA  +         L +A+  G    +  LL 
Sbjct: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLA 224

Query: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
           +GA +     +G T+L LAA   +    ++L  HGAD     + G + L  A   G++  
Sbjct: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284

Query: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803
           V  L+ QGA V+A+   G TPLH A+++GH  +   LL  GA+ +AT     T L +A  
Sbjct: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344

Query: 804 LGYISVVDTL--KVVTEEVTTTTTTITEKHKLNVPETMTEV 842
            G+   V  L  +  +  + T    + +  + ++P+ + E+
Sbjct: 345 RGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPEL 385



 Score =  124 bits (310), Expect = 2e-27
 Identities = 113/349 (32%), Positives = 157/349 (44%), Gaps = 29/349 (8%)

Query: 130 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN---- 185
           G+  L  A       +V  LL  GA+       G TPL +A+ +GH   V +LL+     
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 186 ---DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
              D  G+    ALH AA    ++ A LLLQ   +A  +S         +G TPLH AA 
Sbjct: 101 GAVDRAGRT---ALHEAAWHGHSRVAELLLQRGASAAARSG--------TGLTPLHWAAA 149

Query: 243 YGNVNVATLLLNRG----AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
            G+  +A  LL       AA +     G T  H A+  G   +++LL   G  +D     
Sbjct: 150 LGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA--- 206

Query: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
               L  AA +G    +  LL RGA + AR   G + L +AA     + ++ LL H A  
Sbjct: 207 ----LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP 262

Query: 359 DDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV 418
                   +ALH AA  GH    +LL+ + A  +AR   G TPLH A ++  ++V   L+
Sbjct: 263 GIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322

Query: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETA 467
             GA + A      TP+H+AA  GH   V LLL  GASP +     E A
Sbjct: 323 DRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371



 Score = 82.0 bits (201), Expect = 1e-14
 Identities = 55/179 (30%), Positives = 86/179 (48%)

Query: 32  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
           + + L AA AG    +   L  G  ++  +  G  AL LAA  G    ++ LLG G+   
Sbjct: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263

Query: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
              + G +ALH A+  G    V++LV +GA ++A+   G TPL+ A++E H++V   LL+
Sbjct: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323

Query: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 210
            GA          TPL +A ++GH   V +LL       +R     +A   +     AL
Sbjct: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382



 Score = 72.4 bits (176), Expect = 8e-12
 Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 1/135 (0%)

Query: 28  KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           +  + A+ L  A A    + +E L G G D    +++G +ALH AA  GH+  VQ L+ +
Sbjct: 232 RDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
           G+ VD+    G T LH AS  G  EV   L+  GA ++A      TPL++AA+  H   V
Sbjct: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351

Query: 147 KYLLENGANQSTATE 161
             LL  GA+ +  T+
Sbjct: 352 GLLLSRGASPTLRTQ 366


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  172 bits (436), Expect = 6e-42
 Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)

Query: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439

Query: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499

Query: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556

Query: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424
             AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594



 Score =  169 bits (429), Expect = 4e-41
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258

Query: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318

Query: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
             V +LL      +                        DHN             E+G TP
Sbjct: 319 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 341

Query: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400

Query: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577

Query: 474 AGQVEVVRCLLRNGALVD 491
            G  +V   LL+ GA +D
Sbjct: 578 NGHTDVADVLLQAGADLD 595



 Score =  168 bits (425), Expect = 1e-40
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 388

Query: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448

Query: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508

Query: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565

Query: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654
             G T L  A +     +A  LL  GA+
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGAD 593



 Score =  141 bits (355), Expect = 1e-32
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 200 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253

Query: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313

Query: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373

Query: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433

Query: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493

Query: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553

Query: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 606



 Score =  137 bits (344), Expect = 3e-31
 Identities = 131/503 (26%), Positives = 218/503 (43%), Gaps = 71/503 (14%)

Query: 54  GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113
           G D+ T +      L    +   +G +    G+  +     ++  +++  A     A + 
Sbjct: 132 GADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALT 191

Query: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173
           ++  +   N     Q     L  A  +  ++ V+ LL+ G + +  TE+G + L +A   
Sbjct: 192 RMKAENSHNAG---QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA 248

Query: 174 GHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESG 233
           G+ +   +LL           A+H                    A+V+     +R  +  
Sbjct: 249 GYYELAQVLL-----------AMH--------------------ANVE-----DRGNKGD 272

Query: 234 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
            TPL  A+  G +++  LLL   A V+  +  G T L  A   G  ++VK+LL+ G  I+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 294 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLL 352
               +G TPL  AA +GH +V  +LL+ GA +   +     S L +A    H++ V+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 353 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412
           +  A  +  T +  TAL  A   GH  V +LLLD  A  N  A +  +PL +A     ++
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV-TNIRGETALHMA 471
           +  LL++ GA+++ + + G TP+  AA  GH  +V LLL  GA+ +  T    ETAL +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 472 ------------------------------ARAGQVEVVRCLLRNGALVDARAREEQTPL 501
                                         ++ G +E+V+ LL +GA V A      T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 502 HIASRLGKTEIVQLLLQHMAHPD 524
             A   G T++  +LLQ  A  D
Sbjct: 573 TYACENGHTDVADVLLQAGADLD 595



 Score =  125 bits (314), Expect = 8e-28
 Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)

Query: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396

Query: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456

Query: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507

Query: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537

Query: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594



 Score = 85.5 bits (210), Expect = 1e-15
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 521 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580

Query: 176 NQAVAILLE 184
                +LL+
Sbjct: 581 TDVADVLLQ 589



 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 194 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253

Query: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313

Query: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 314 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 365

Query: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 366 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 407


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  172 bits (436), Expect = 6e-42
 Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)

Query: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376

Query: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 377 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428

Query: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488

Query: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 545

Query: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424
             AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583



 Score =  169 bits (429), Expect = 4e-41
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247

Query: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307

Query: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
             V +LL      +                        DHN             E+G TP
Sbjct: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330

Query: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389

Query: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449

Query: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509

Query: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566

Query: 474 AGQVEVVRCLLRNGALVD 491
            G  +V   LL+ GA +D
Sbjct: 567 NGHTDVADVLLQAGADLD 584



 Score =  168 bits (425), Expect = 1e-40
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260

Query: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320

Query: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377

Query: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437

Query: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497

Query: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554

Query: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654
             G T L  A +     +A  LL  GA+
Sbjct: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582



 Score =  160 bits (406), Expect = 2e-38
 Identities = 119/388 (30%), Positives = 189/388 (48%), Gaps = 33/388 (8%)

Query: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
           +L  A   G     + LLD+  + N     G + L +AC     ++ ++L+   A+++  
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 428 TESG-LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
              G +TP+  A+  G+L+IV LLL + A  +  +  G TAL  A   G V++V+ LL  
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN-GYTPLHISAREGQVDV 545
           GA ++       TPL  A+  G  E+ ++LL H A  +  +     + L ++  +G +D+
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376

Query: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
              LLEAGA     T +  T L  A   G ++VA+LLL   A  +    +  +PL +AA 
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436

Query: 606 YDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG--- 662
             + ++A LL+E+GA+       GYTPL  AA++   ++ + LL  GA  N  T++    
Sbjct: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496

Query: 663 ----------------------------VTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
                                        TPL  ASQEGH ++V  LL  GAN+H +T +
Sbjct: 497 ALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTAT 556

Query: 695 GLTSLHLAAQEDKVNVADILTKHGADQD 722
           G T+L  A +    +VAD+L + GAD D
Sbjct: 557 GDTALTYACENGHTDVADVLLQAGADLD 584



 Score =  141 bits (355), Expect = 1e-32
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242

Query: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302

Query: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362

Query: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422

Query: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482

Query: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542

Query: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595



 Score =  136 bits (342), Expect = 5e-31
 Identities = 120/420 (28%), Positives = 191/420 (45%), Gaps = 68/420 (16%)

Query: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196
           A  +  ++ V+ LL+ G + +  TE+G + L +A   G+ +   +LL           A+
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL-----------AM 249

Query: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
           H                    A+V+     +R  +   TPL  A+  G +++  LLL   
Sbjct: 250 H--------------------ANVE-----DRGNKGDITPLMAASSGGYLDIVKLLLLHD 284

Query: 257 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 316
           A V+  +  G T L  A   G  ++VK+LL+ G  I+    +G TPL  AA +GH +V  
Sbjct: 285 ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344

Query: 317 LLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
           +LL+ GA +   +     S L +A    H++ V+ LL+  A  +  T +  TAL  A   
Sbjct: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404

Query: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
           GH  V +LLLD  A  N  A +  +PL +A     +++  LL++ GA+++ + + G TP+
Sbjct: 405 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 464

Query: 436 HVAAFMGHLNIVLLLLQNGASPDV-TNIRGETALHMA----------------------- 471
             AA  GH  +V LLL  GA+ +  T    ETAL +A                       
Sbjct: 465 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC 524

Query: 472 -------ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
                  ++ G +E+V+ LL +GA V A      T L  A   G T++  +LLQ  A  D
Sbjct: 525 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584



 Score =  125 bits (314), Expect = 8e-28
 Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)

Query: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 326 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 385

Query: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 386 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 445

Query: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 446 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 496

Query: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 497 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 526

Query: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L
Sbjct: 527 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583



 Score = 85.5 bits (210), Expect = 1e-15
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)

Query: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449

Query: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509

Query: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 510 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 569

Query: 176 NQAVAILLE 184
                +LL+
Sbjct: 570 TDVADVLLQ 578



 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242

Query: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302

Query: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354

Query: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.126    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 158,853,394
Number of Sequences: 37866
Number of extensions: 8220390
Number of successful extensions: 66788
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 510
Number of HSP's successfully gapped in prelim test: 1661
Number of HSP's that attempted gapping in prelim test: 31723
Number of HSP's gapped (non-prelim): 22256
length of query: 3957
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3835
effective length of database: 13,627,866
effective search space: 52262866110
effective search space used: 52262866110
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.