Search of human proteins with 52353306

Search of human proteins with 52353306

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
         (341 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|52353306 leucine rich repeat containing 55 [Homo sapiens]          714   0.0  
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti...   160   1e-39
gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ...   155   4e-38
gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ...   155   4e-38
gi|194018474 leucine rich repeat containing 52 [Homo sapiens]         142   6e-34
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]          126   3e-29
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...   122   5e-28
gi|188528675 slit homolog 1 [Homo sapiens]                            103   3e-22
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         102   4e-22
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                102   4e-22
gi|4759146 slit homolog 2 [Homo sapiens]                               99   7e-21
gi|11321571 slit homolog 3 [Homo sapiens]                              94   1e-19
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]       89   6e-18
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              86   4e-17
gi|194306623 immunoglobulin superfamily containing leucine-rich ...    86   4e-17
gi|194306621 immunoglobulin superfamily containing leucine-rich ...    86   4e-17
gi|39930401 immunoglobulin superfamily containing leucine-rich r...    86   4e-17
gi|194306618 immunoglobulin superfamily containing leucine-rich ...    86   4e-17
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    85   1e-16
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    85   1e-16
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                 85   1e-16
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...    84   1e-16
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]             83   3e-16
gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]    82   5e-16
gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]     82   5e-16
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    82   9e-16
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    82   9e-16
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]     81   2e-15
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]         80   3e-15
gi|139948432 adlican [Homo sapiens]                                    80   3e-15

>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score =  714 bits (1842), Expect = 0.0
 Identities = 341/341 (100%), Positives = 341/341 (100%)

Query: 1   MLRSPTFTDAGPRCSCLPVSQTLDSMDTVLMGSLQHCCCLLPKMGDTWAQLPWPGPPHPA 60
           MLRSPTFTDAGPRCSCLPVSQTLDSMDTVLMGSLQHCCCLLPKMGDTWAQLPWPGPPHPA
Sbjct: 1   MLRSPTFTDAGPRCSCLPVSQTLDSMDTVLMGSLQHCCCLLPKMGDTWAQLPWPGPPHPA 60

Query: 61  MLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRI 120
           MLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRI
Sbjct: 61  MLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRI 120

Query: 121 TAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAH 180
           TAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAH
Sbjct: 121 TAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAH 180

Query: 181 GLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNP 240
           GLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNP
Sbjct: 181 GLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNP 240

Query: 241 WVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDD 300
           WVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDD
Sbjct: 241 WVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDD 300

Query: 301 YLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEEI 341
           YLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEEI
Sbjct: 301 YLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEEI 341


>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
           [Homo sapiens]
          Length = 254

 Score =  160 bits (406), Expect = 1e-39
 Identities = 91/248 (36%), Positives = 128/248 (51%), Gaps = 1/248 (0%)

Query: 93  DCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLF 152
           DC  + L SVP   P+D R L +A NRI  +P  +   Y +L  LD  NNSL  L  G F
Sbjct: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60

Query: 153 LHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDL 212
             + +L  LDLSYNN + + A  F+ A  LV + L++N  L  VH  AF+ L  L+ L+L
Sbjct: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNN-LVGVHEDAFETLESLQVLEL 119

Query: 213 SYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRG 272
           +   L  LS+ AL  LP L +L++ GNPW+C C    L  W++    +        +C  
Sbjct: 120 NDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSL 179

Query: 273 PPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRW 332
           P E     L  L+E SF  C  +L+L D   I F G  VSIA++ ++F L     C  R 
Sbjct: 180 PMESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRC 239

Query: 333 SKASEEEE 340
           +   + E+
Sbjct: 240 APNKDAED 247


>gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  155 bits (393), Expect = 4e-38
 Identities = 88/240 (36%), Positives = 124/240 (51%), Gaps = 1/240 (0%)

Query: 101 SVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAH 160
           SVP   P+D R L +A NRI  +P  +   Y +L  LD  NNSL  L  G F  + +L  
Sbjct: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222

Query: 161 LDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFL 220
           LDLSYNN + + A  F+ A  LV + L++N  L  VH  AF+ L  L+ L+L+   L  L
Sbjct: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNN-LVGVHEDAFETLESLQVLELNDNNLRSL 281

Query: 221 SLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAP 280
           S+ AL  LP L +L++ GNPW+C C    L  W++    +        +C  P E     
Sbjct: 282 SVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRIS 341

Query: 281 LFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEE 340
           L  L+E SF  C  +L+L D   I F G  VSIA++ ++F L     C  R +   + E+
Sbjct: 342 LRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAED 401


>gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  155 bits (393), Expect = 4e-38
 Identities = 88/240 (36%), Positives = 124/240 (51%), Gaps = 1/240 (0%)

Query: 101 SVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAH 160
           SVP   P+D R L +A NRI  +P  +   Y +L  LD  NNSL  L  G F  + +L  
Sbjct: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222

Query: 161 LDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFL 220
           LDLSYNN + + A  F+ A  LV + L++N  L  VH  AF+ L  L+ L+L+   L  L
Sbjct: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNN-LVGVHEDAFETLESLQVLELNDNNLRSL 281

Query: 221 SLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAP 280
           S+ AL  LP L +L++ GNPW+C C    L  W++    +        +C  P E     
Sbjct: 282 SVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRIS 341

Query: 281 LFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEE 340
           L  L+E SF  C  +L+L D   I F G  VSIA++ ++F L     C  R +   + E+
Sbjct: 342 LRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAED 401


>gi|194018474 leucine rich repeat containing 52 [Homo sapiens]
          Length = 313

 Score =  142 bits (357), Expect = 6e-34
 Identities = 95/287 (33%), Positives = 138/287 (48%), Gaps = 10/287 (3%)

Query: 57  PHPAMLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLA 116
           P P  LL S     GL+   +G+ CP  C C+ Q V C+ ++L   P D+P++TR L L 
Sbjct: 7   PGPGWLLFSF--GMGLV---SGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLN 61

Query: 117 HNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMF 176
            NRIT++P  +L    +L  LD  NN + E+    F+   +L +LDLS NN + +    F
Sbjct: 62  ENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTF 121

Query: 177 QEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQI 236
                LV +++++NP L  +H   F     LR LDL   GL  L   AL  L  L TL +
Sbjct: 122 SVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFL 181

Query: 237 GGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTL 296
            GNPW C C+      +L        +D   A C  P E+ G P+  +       C   L
Sbjct: 182 SGNPWKCNCSFLDFAIFLIV-FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHL 240

Query: 297 TLDDYLFIAFVGFVVSIASVATNFLLGITA----NCCHRWSKASEEE 339
              DY+F+  +GF +  A     +L G+ A    N  H+ S+  E+E
Sbjct: 241 DHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDE 287


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score =  126 bits (316), Expect = 3e-29
 Identities = 95/296 (32%), Positives = 131/296 (44%), Gaps = 19/296 (6%)

Query: 45  GDTWAQLPWPGPPHPAMLLISLL----------LAAGLMHSDAGTSCPVLCTC-RNQVVD 93
           G +W++      P P +LL+ LL            A    S     CP +CTC    +  
Sbjct: 3   GPSWSR------PRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLAS 56

Query: 94  CSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFL 153
           CS+  L +VPP L +  R L L HNR+ A+PPG       LQ LDL  N L  +    F 
Sbjct: 57  CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFW 116

Query: 154 HAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLS 213
               L  LDLS N    +    F     L ++ L+ N  L R+ P A   L  LR L L 
Sbjct: 117 GLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNR-LARLEPAALGALPLLRSLSLQ 175

Query: 214 YGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGP 273
              LA L+   L  LP L  L + GNPW CGC + PL  WLR R     ++++   C  P
Sbjct: 176 DNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLR-RHPLPASEAETVLCVWP 234

Query: 274 PEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCC 329
             +  +PL + ++ +F  C   L L D   +  +G    + S+A+   LG     C
Sbjct: 235 GRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTAC 290


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score =  122 bits (306), Expect = 5e-28
 Identities = 80/219 (36%), Positives = 106/219 (48%), Gaps = 4/219 (1%)

Query: 76  DAGTSCPVLCTC--RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYME 133
           +A  +CP  C C  R+  VDCS   L +VPPD+P  TR L L +N+++A+P         
Sbjct: 34  EALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSS 93

Query: 134 LQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWL 193
           LQ LDL NN L  LPR +F     L  L L  N+   +  D+ + +  L H+DLS N  L
Sbjct: 94  LQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSIN-GL 152

Query: 194 RRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKW 253
            ++ P  F GL+ LR L L    L  L     E L  L  LQ+G NPW C C +     W
Sbjct: 153 AQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHW 212

Query: 254 LRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKAC 292
           +     R     QLA C  P E+ G  +  +  E F  C
Sbjct: 213 MEWFSYRGGRLDQLA-CTLPKELRGKDMRMVPMEMFNYC 250


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  103 bits (256), Expect = 3e-22
 Identities = 61/211 (28%), Positives = 101/211 (47%), Gaps = 5/211 (2%)

Query: 80  SCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDL 139
           SCP +CTC N +VDC  + L ++P +LP     + L  N I ++PPG  + Y +L+ +DL
Sbjct: 281 SCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDL 340

Query: 140 HNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQ 199
            NN + E+    F   + L  L L  N  + +P  +F   + L  + L+ N  +  + P 
Sbjct: 341 SNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANK-INCIRPD 399

Query: 200 AFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQ 259
           AFQ L  L  L L    +  L+      L  + TL +  NP++C C     LKWL + ++
Sbjct: 400 AFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCN----LKWLADFLR 455

Query: 260 RCTADSQLAECRGPPEVEGAPLFSLTEESFK 290
               ++  A C  P  +    +  +  + F+
Sbjct: 456 TNPIETSGARCASPRRLANKRIGQIKSKKFR 486



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 73/259 (28%), Positives = 109/259 (42%), Gaps = 33/259 (12%)

Query: 55  GPPHPAMLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLS 114
           GP  P + L+    A  L      ++CP LCTC    VDC    L ++P ++P +T  L 
Sbjct: 12  GPVRPELWLLLWAAAWRL----GASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLE 67

Query: 115 LAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPAD 174
           L  N IT +         +L+VL L  N +  + RG F   K L  L L+ N    +P  
Sbjct: 68  LNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPEL 127

Query: 175 MFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGL------AFLSLEALEGL 228
           +FQ    L  +DLS N  ++ +  +AF+G   L++L L    +      AF +L  LE L
Sbjct: 128 LFQNNQALSRLDLSENA-IQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVL 186

Query: 229 ------------------PGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAEC 270
                             P L T ++  N   C C +  L +WLR R           +C
Sbjct: 187 TLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQR----PTIGLFTQC 242

Query: 271 RGPPEVEGAPLFSLTEESF 289
            GP  + G  +  + +  F
Sbjct: 243 SGPASLRGLNVAEVQKSEF 261



 Score = 95.1 bits (235), Expect = 8e-20
 Identities = 64/210 (30%), Positives = 94/210 (44%), Gaps = 30/210 (14%)

Query: 81  CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLH 140
           CP  C C + VV CS++ L ++P  +P +   L L  N+ T VP G L+ +  LQ++DL 
Sbjct: 734 CPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVDLS 792

Query: 141 NNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQA 200
           NN +  L    F +  +L  L LSYN    +P                         P A
Sbjct: 793 NNKISSLSNSSFTNMSQLTTLILSYNALQCIP-------------------------PLA 827

Query: 201 FQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQR 260
           FQGL  LR L L    ++ L       +  L  L IG NP  C C     L+WL + ++ 
Sbjct: 828 FQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCH----LRWLSSWVKT 883

Query: 261 CTADSQLAECRGPPEVEGAPLFSLTEESFK 290
              +  +A C GP ++EG  L +   + F+
Sbjct: 884 GYKEPGIARCAGPQDMEGKLLLTTPAKKFE 913



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 63/211 (29%), Positives = 100/211 (47%), Gaps = 6/211 (2%)

Query: 81  CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAV-PPGYLTCYMELQVLDL 139
           CP  C C   VV+CSS +L  +P  +P  T  L L +N I+ +   G       L+ ++L
Sbjct: 513 CPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINL 572

Query: 140 HNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQ 199
            NN + E+  G F  A  ++ L L+ N    + + MF+   GL  + L +N  +  +H  
Sbjct: 573 SNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNR-ISCIHND 631

Query: 200 AFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQ 259
           +F GL  +R L L    +  +S  A + L  L TL +  NP+ C C +  L  WLR R +
Sbjct: 632 SFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKR-K 690

Query: 260 RCTADSQLAECRGPPEVEGAPLFSLTEESFK 290
             T + +   C+ P  +   PL  +    F+
Sbjct: 691 IVTGNPR---CQNPDFLRQIPLQDVAFPDFR 718


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  102 bits (255), Expect = 4e-22
 Identities = 80/254 (31%), Positives = 108/254 (42%), Gaps = 33/254 (12%)

Query: 59  PAMLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHN 118
           P +LL+  L AAG         CP  C C +  V+C + RL  VP  +P  T+ L L  N
Sbjct: 10  PLLLLLLPLRAAG---------CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDN 60

Query: 119 RITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMF-- 176
            I  + PG L     L+ L LHNNSL  L  G F    RL  L L+ N    + +  F  
Sbjct: 61  NIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG 120

Query: 177 -----------QEAHGLVHIDLSHNPWLRRVH----------PQAFQGLMQLRDLDLSYG 215
                       +   L+     H P L+ +H           QA  GL  L  LDLS  
Sbjct: 121 LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRN 180

Query: 216 GLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQR-CTADSQLAECRGPP 274
            L  +S EAL+ L  L  L++  NPW C C +  L  W++   QR  T+  +   C  PP
Sbjct: 181 QLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPP 240

Query: 275 EVEGAPLFSLTEES 288
            +    L  ++  S
Sbjct: 241 RLALQSLLDVSHSS 254


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  102 bits (255), Expect = 4e-22
 Identities = 91/308 (29%), Positives = 118/308 (38%), Gaps = 81/308 (26%)

Query: 57  PHPAMLLISLLLAAGLMHSDAGTSCPVLCTCRNQ--VVDCSSQRLFSVPPDLPMDTRNLS 114
           P  A LL+ +LLA  L    A  SCP+LCTC +    V C +    SVP  LP  T+ L 
Sbjct: 12  PASACLLL-MLLALPL----AAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLF 66

Query: 115 LAH----------------------NRITAVPPGYLTCYMELQVLDLHNN---------- 142
           L +                      N ++ + PG       L+ LDL +N          
Sbjct: 67  LQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDT 126

Query: 143 ---------------SLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDL 187
                           L  LP  +F     L +L L  N+  H+  D+F +   L H+ L
Sbjct: 127 FQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFL 186

Query: 188 S-----------------------HNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEA 224
                                   H   L+ VH  AF+GL +L  L L    LA L  EA
Sbjct: 187 HGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEA 246

Query: 225 LEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSL 284
           L  LP L  L++  NPW C C   PL  W     QR    S    C  PPE +G  L +L
Sbjct: 247 LADLPSLEFLRLNANPWACDCRARPLWAW----FQRARVSSSDVTCATPPERQGRDLRAL 302

Query: 285 TEESFKAC 292
            E  F+AC
Sbjct: 303 READFQAC 310


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 98.6 bits (244), Expect = 7e-21
 Identities = 59/210 (28%), Positives = 95/210 (45%), Gaps = 5/210 (2%)

Query: 81  CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLH 140
           CP  CTC N +VDC  + L  +P +LP     + L  N I  +PPG  + Y +L+ +DL 
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332

Query: 141 NNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQA 200
           NN + EL    F   + L  L L  N  + +P  +F+    L  + L+ N  +  +   A
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANK-INCLRVDA 391

Query: 201 FQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQR 260
           FQ L  L  L L    L  ++      L  + T+ +  NP++C C     LKWL + +  
Sbjct: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCH----LKWLADYLHT 447

Query: 261 CTADSQLAECRGPPEVEGAPLFSLTEESFK 290
              ++  A C  P  +    +  +  + F+
Sbjct: 448 NPIETSGARCTSPRRLANKRIGQIKSKKFR 477



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 72/253 (28%), Positives = 108/253 (42%), Gaps = 29/253 (11%)

Query: 61  MLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRI 120
           ML +SL L   +++  A  +CP  C+C    VDC    L SVP ++P +T  L L  N I
Sbjct: 8   MLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNI 67

Query: 121 TAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAH 180
           T +          L+VL L  N +  + RG F   K L  L L+ N+    P  +F    
Sbjct: 68  TRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTA 127

Query: 181 GLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGL------AFLSLEALEGL------ 228
            L  +DLS N  ++ +  +AF+G + +++L L Y  +      AF +L  LE L      
Sbjct: 128 KLYRLDLSENQ-IQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNN 186

Query: 229 ------------PGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEV 276
                       P L T ++  N   C C +  L  WLR R           +C GP  +
Sbjct: 187 ITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQR----PRVGLYTQCMGPSHL 242

Query: 277 EGAPLFSLTEESF 289
            G  +  + +  F
Sbjct: 243 RGHNVAEVQKREF 255



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 64/209 (30%), Positives = 91/209 (43%), Gaps = 30/209 (14%)

Query: 81  CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLH 140
           CP  CTC + VV CS++ L  +P  +P D   L L  N+ T VP   L+ Y  L ++DL 
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLIDLS 785

Query: 141 NNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQA 200
           NN +  L    F +  +L  L LSYN                          LR + P+ 
Sbjct: 786 NNRISTLSNQSFSNMTQLLTLILSYNR-------------------------LRCIPPRT 820

Query: 201 FQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQR 260
           F GL  LR L L    ++ +   A   L  L  L IG NP  C C M+ L  W+++  + 
Sbjct: 821 FDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYK- 879

Query: 261 CTADSQLAECRGPPEVEGAPLFSLTEESF 289
              +  +A C GP E+    L +   + F
Sbjct: 880 ---EPGIARCAGPGEMADKLLLTTPSKKF 905



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 2/182 (1%)

Query: 77  AGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAV-PPGYLTCYMELQ 135
           A  +CP  C C    VDCS+Q+L  +P  +P  T  L L +N  T +   G      +L+
Sbjct: 502 ADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLR 561

Query: 136 VLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRR 195
            ++  NN + ++  G F  A  +  + L+ N   +V   MF+    L  + L  N  +  
Sbjct: 562 KINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNR-ITC 620

Query: 196 VHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR 255
           V   +F GL  +R L L    +  ++  A + L  L TL +  NP+ C C +  L +WLR
Sbjct: 621 VGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLR 680

Query: 256 NR 257
            +
Sbjct: 681 KK 682


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 60/211 (28%), Positives = 93/211 (44%), Gaps = 5/211 (2%)

Query: 80  SCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDL 139
           SCP  CTC N +VDC  + L  +P +LP     + L  N I A+P G  T Y +L+ +D+
Sbjct: 279 SCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDI 338

Query: 140 HNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQ 199
             N + ++    F   K L  L L  N  + +   +F     L  + L+ N  +  +   
Sbjct: 339 SKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANK-INCLRVN 397

Query: 200 AFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQ 259
            FQ L  L  L L    L  +S      L  + TL +  NP+VC C     LKWL + +Q
Sbjct: 398 TFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCH----LKWLADYLQ 453

Query: 260 RCTADSQLAECRGPPEVEGAPLFSLTEESFK 290
               ++  A C  P  +    +  +  + F+
Sbjct: 454 DNPIETSGARCSSPRRLANKRISQIKSKKFR 484



 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 69/251 (27%), Positives = 104/251 (41%), Gaps = 30/251 (11%)

Query: 53  WPGPPHPAMLLISLLLA-AGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTR 111
           W G        ++L LA A ++      +CP  CTC    VDC    L +VP  +P +  
Sbjct: 5   WAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64

Query: 112 NLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHV 171
            L L  N IT +          L+VL L +N +  + RG F   K+L  L L+ N    +
Sbjct: 65  RLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL 124

Query: 172 PADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGL------AFLSLEAL 225
           P  +FQ    L  +DLS N  ++ +  +AF+G+  +++L L    +      AF +L  L
Sbjct: 125 PELLFQSTPKLTRLDLSENQ-IQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDL 183

Query: 226 E------------------GLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQL 267
           E                   +P + TL++  N   C C +  L  WLR R        Q 
Sbjct: 184 EILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR----RTVGQF 239

Query: 268 AECRGPPEVEG 278
             C  P  + G
Sbjct: 240 TLCMAPVHLRG 250



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 63/213 (29%), Positives = 93/213 (43%), Gaps = 43/213 (20%)

Query: 81  CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLH 140
           CP  CTC   VV CS++ L ++P  +P D   L L  N +TAV P  L+    L ++DL 
Sbjct: 725 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLS 783

Query: 141 NNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQA 200
           NNS+  L    F +   L+ L LSYN    +P          VH               A
Sbjct: 784 NNSISMLTNYTFSNMSHLSTLILSYNRLRCIP----------VH---------------A 818

Query: 201 FQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR----- 255
           F GL  LR L L    ++ +   +   L  L  L +G NP  C C++  L +W++     
Sbjct: 819 FNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKE 878

Query: 256 NRIQRCTADSQLA------------ECRGPPEV 276
             I RC++   +A            +C+GP ++
Sbjct: 879 PGIARCSSPEPMADRLLLTTPTHRFQCKGPVDI 911



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 55/178 (30%), Positives = 82/178 (46%), Gaps = 2/178 (1%)

Query: 81  CPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAV-PPGYLTCYMELQVLDL 139
           CP  C C   +VDCS+Q+L  +P  LP    +L L  N ++ +   G       L+ ++L
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINL 564

Query: 140 HNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQ 199
            NN + E+  G F  A  +  L L+ N    V   +F+   GL  + L  N  +  V   
Sbjct: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSN-LIGCVSND 623

Query: 200 AFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNR 257
            F GL  +R L L    +  ++  A   L  L T+ +  NP+ C C +  L KWLR R
Sbjct: 624 TFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKR 681


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score = 89.0 bits (219), Expect = 6e-18
 Identities = 74/310 (23%), Positives = 127/310 (40%), Gaps = 53/310 (17%)

Query: 62  LLISLLLAAGLMHSDAGTSCPVLCTCRNQV-VDCSSQRLFSVPPDLPMDTRNLSLAHNRI 120
           LL+S  +   L+ +  G +CP  C C     V C+ + L S+P  +P +   ++L +N +
Sbjct: 11  LLVSFAVIC-LVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSL 69

Query: 121 TAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAH 180
             +     +   +L++L LH+N +  +P   F   + L  L +SYN    +  D F    
Sbjct: 70  VRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLR 129

Query: 181 GLVHIDLSHN-----------------------PWLRRVHPQAFQGLMQLRDLDLSYGGL 217
            L  + + HN                         L ++HP  F  L  L+   +S+   
Sbjct: 130 SLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF 189

Query: 218 AFLS--------LEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNR--IQRCTAD--- 264
            +LS         E +  +P L +L + GNPW C C ++ L  W++ +  + +C  D   
Sbjct: 190 LYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSP 249

Query: 265 ---SQLAECRGPPEVEGAPLFSLT-----------EESFKACHLTLTLD-DYLFIAFVGF 309
               Q   C  P   +G PL  ++           + S K+  LT+  D    FI+  GF
Sbjct: 250 SSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGF 309

Query: 310 VVSIASVATN 319
           +    S+  N
Sbjct: 310 MAPFGSLTLN 319


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 59/168 (35%), Positives = 72/168 (42%), Gaps = 5/168 (2%)

Query: 125 PGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVH 184
           PG       LQ L L +N+L  LP   F     L HL L  N  S VP   F+  H L  
Sbjct: 147 PGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206

Query: 185 IDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCG 244
           + L H   +  VHP AF+ L +L  L L    L+ L  EAL  L  L  L++  NPWVC 
Sbjct: 207 L-LLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCD 265

Query: 245 CTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKAC 292
           C   PL  WL    Q+    S    C  P  + G  L  L     + C
Sbjct: 266 CRARPLWAWL----QKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGC 309



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 48/162 (29%), Positives = 60/162 (37%), Gaps = 27/162 (16%)

Query: 81  CPVLCTCRNQ---VVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVL 137
           CP  C C N+      C  Q L +VP  +P  ++ + L  NRI+ VP         L +L
Sbjct: 27  CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86

Query: 138 DLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVH 197
            LH+N L  +    F     L  LDLS                         N  LR V 
Sbjct: 87  WLHSNVLARIDAAAFTGLALLEQLDLS------------------------DNAQLRSVD 122

Query: 198 PQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGN 239
           P  F GL +L  L L   GL  L      GL  L  L +  N
Sbjct: 123 PATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDN 164



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 3/98 (3%)

Query: 99  LFSVPPDLPMDTRNLS---LAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHA 155
           L ++P D   D  NL+   L  NRI++VP         L  L LH N +  +    F   
Sbjct: 166 LQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDL 225

Query: 156 KRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWL 193
            RL  L L  NN S +P +       L ++ L+ NPW+
Sbjct: 226 GRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWV 263


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 63/210 (30%), Positives = 96/210 (45%), Gaps = 8/210 (3%)

Query: 80  SCPVLCTC----RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQ 135
           SCP  C C     +Q  DC+ + L  VP  LP +   LSL+ N+IT +  G      ++ 
Sbjct: 19  SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVT 78

Query: 136 VLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRR 195
            L L +N +  +  G      +L +LDLS+N  S  P    +    L  + ++HN  L  
Sbjct: 79  SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNR-LGS 137

Query: 196 VHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR 255
           +   A   L  LR L ++   L  L+    + L  L  LQ+  NP+ CGC +  L  W  
Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197

Query: 256 N-RIQRCTADSQLAECRGPPEVEGAPLFSL 284
           + R+     DS    C  PP ++G P++ L
Sbjct: 198 STRVSLPEPDS--IACASPPALQGVPVYRL 225


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 63/210 (30%), Positives = 96/210 (45%), Gaps = 8/210 (3%)

Query: 80  SCPVLCTC----RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQ 135
           SCP  C C     +Q  DC+ + L  VP  LP +   LSL+ N+IT +  G      ++ 
Sbjct: 19  SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVT 78

Query: 136 VLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRR 195
            L L +N +  +  G      +L +LDLS+N  S  P    +    L  + ++HN  L  
Sbjct: 79  SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNR-LGS 137

Query: 196 VHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR 255
           +   A   L  LR L ++   L  L+    + L  L  LQ+  NP+ CGC +  L  W  
Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197

Query: 256 N-RIQRCTADSQLAECRGPPEVEGAPLFSL 284
           + R+     DS    C  PP ++G P++ L
Sbjct: 198 STRVSLPEPDS--IACASPPALQGVPVYRL 225


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 63/210 (30%), Positives = 96/210 (45%), Gaps = 8/210 (3%)

Query: 80  SCPVLCTC----RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQ 135
           SCP  C C     +Q  DC+ + L  VP  LP +   LSL+ N+IT +  G      ++ 
Sbjct: 19  SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVT 78

Query: 136 VLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRR 195
            L L +N +  +  G      +L +LDLS+N  S  P    +    L  + ++HN  L  
Sbjct: 79  SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNR-LGS 137

Query: 196 VHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR 255
           +   A   L  LR L ++   L  L+    + L  L  LQ+  NP+ CGC +  L  W  
Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197

Query: 256 N-RIQRCTADSQLAECRGPPEVEGAPLFSL 284
           + R+     DS    C  PP ++G P++ L
Sbjct: 198 STRVSLPEPDS--IACASPPALQGVPVYRL 225


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 63/210 (30%), Positives = 96/210 (45%), Gaps = 8/210 (3%)

Query: 80  SCPVLCTC----RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQ 135
           SCP  C C     +Q  DC+ + L  VP  LP +   LSL+ N+IT +  G      ++ 
Sbjct: 19  SCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVT 78

Query: 136 VLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRR 195
            L L +N +  +  G      +L +LDLS+N  S  P    +    L  + ++HN  L  
Sbjct: 79  SLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNR-LGS 137

Query: 196 VHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR 255
           +   A   L  LR L ++   L  L+    + L  L  LQ+  NP+ CGC +  L  W  
Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197

Query: 256 N-RIQRCTADSQLAECRGPPEVEGAPLFSL 284
           + R+     DS    C  PP ++G P++ L
Sbjct: 198 STRVSLPEPDS--IACASPPALQGVPVYRL 225


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 60/183 (32%), Positives = 83/183 (45%), Gaps = 4/183 (2%)

Query: 113 LSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVP 172
           LSL  N +  +P G       L  L L +N L  +  G F H   L  L LSYN  +H+P
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329

Query: 173 ADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLV 232
           A +F++   LV + L  N  L  +HP  FQ L +L  L LS   L  L     +    L 
Sbjct: 330 AGIFRDLEELVKLYLGSNN-LTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLF 388

Query: 233 TLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKAC 292
            L + GNPW C C +  L  WL+    R    +    C GP  ++G  + +L E+    C
Sbjct: 389 NLALHGNPWQCDCHLAYLFNWLQQYTDRLL--NIQTYCAGPAYLKGQVVPALNEKQL-VC 445

Query: 293 HLT 295
            +T
Sbjct: 446 PVT 448



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 51/198 (25%), Positives = 81/198 (40%), Gaps = 25/198 (12%)

Query: 66  LLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVP- 124
           LL  + L+ +     CP+ C C  Q V CS + L +VP D+P  T+N+       T +  
Sbjct: 7   LLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLET 66

Query: 125 -----------------------PGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHL 161
                                  P        L+ L++  +S + L   +F +   L  L
Sbjct: 67  RAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKL 126

Query: 162 DLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLS 221
            L++N    +P  +FQ    L  + L  N  L+ +  + FQ L  L+ L+L+   LA L 
Sbjct: 127 TLNFNMLEALPEGLFQHLAALESLHLQGNQ-LQALPRRLFQPLTHLKTLNLAQNLLAQLP 185

Query: 222 LEALEGLPGLVTLQIGGN 239
            E    L  L TL++  N
Sbjct: 186 EELFHPLTSLQTLKLSNN 203



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 44/144 (30%), Positives = 67/144 (46%), Gaps = 8/144 (5%)

Query: 67  LLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPG 126
           +L AGL    A T C V  +  +  ++  ++  F+   +L    R+L L++N IT +P G
Sbjct: 279 VLPAGLF---AHTPCLVGLSLTHNQLETVAEGTFAHLSNL----RSLMLSYNAITHLPAG 331

Query: 127 YLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHID 186
                 EL  L L +N+L  L   LF +  +L  L LS N  + +P  +F   + L ++ 
Sbjct: 332 IFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLA 391

Query: 187 LSHNPWLRRVH-PQAFQGLMQLRD 209
           L  NPW    H    F  L Q  D
Sbjct: 392 LHGNPWQCDCHLAYLFNWLQQYTD 415



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 39/129 (30%), Positives = 54/129 (41%), Gaps = 1/129 (0%)

Query: 111 RNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSH 170
           + L+LA N +  +P         LQ L L NN+L  LP+G+F     L  L L  NN S 
Sbjct: 172 KTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISE 231

Query: 171 VPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPG 230
           +P  +F +   L  + L  N  +  +    F  L  L  L L +  L  L        P 
Sbjct: 232 LPPQVFSQLFCLERLWLQRNA-ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPC 290

Query: 231 LVTLQIGGN 239
           LV L +  N
Sbjct: 291 LVGLSLTHN 299



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 38/128 (29%), Positives = 53/128 (41%), Gaps = 1/128 (0%)

Query: 112 NLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHV 171
           +L L  N++ A+P         L+ L+L  N L +LP  LF     L  L LS N  S +
Sbjct: 149 SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208

Query: 172 PADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGL 231
           P  +F +   L  + L  N  +  + PQ F  L  L  L L    +  L L     L  L
Sbjct: 209 PQGVFGKLGSLQELFLDSNN-ISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267

Query: 232 VTLQIGGN 239
             L +  N
Sbjct: 268 TFLSLQWN 275


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 65/231 (28%), Positives = 98/231 (42%), Gaps = 4/231 (1%)

Query: 66  LLLAAGLMHSDAGTSCPVLCTCRNQV--VDCSSQRLFSVPPDLPMDTRNLSLAHNRITAV 123
           LL ++ ++      SCP  C C++    VDCS Q L  +P  LP  TR L L  N+I  +
Sbjct: 6   LLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHL 65

Query: 124 PPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLV 183
           P         L  L+L NNSL  L  G F   + L  L+L+ N+   + + +F     L 
Sbjct: 66  PAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLR 125

Query: 184 HIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVC 243
            +DLS N  +  +     +    L  L +    L  L    LE +P +  L +  N W C
Sbjct: 126 ELDLSSNN-ISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKC 184

Query: 244 GCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHL 294
            C +  L  WL   + +      +  C  P   +G  L  +  E ++ C L
Sbjct: 185 NCHLLGLKLWLEKFVYKGGLTDGII-CESPDTWKGKDLLRIPHELYQPCPL 234


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 81/302 (26%), Positives = 115/302 (38%), Gaps = 79/302 (26%)

Query: 63  LISLLLAAGLMHSDAGTSCPVLCTC--RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRI 120
           L+ LL+AA L     G  CP  C C      V C +    ++P  +P+D+  + L +NRI
Sbjct: 10  LLLLLVAAEL---PLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRI 66

Query: 121 TAVPPGYLTC----------------------YMELQVLDLHNN---------------- 142
             + PG+ +                       ++ L+ LDL +N                
Sbjct: 67  GLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVK 126

Query: 143 ---------SLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEA-------------- 179
                     L  LP G+F     L +L L  N+  ++  D+F +               
Sbjct: 127 LHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLW 186

Query: 180 -------HGLVHID--LSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPG 230
                   GLV++D  L H   L+ VH +AF  L +L  L L    L+ L  E L  L  
Sbjct: 187 SLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGA 246

Query: 231 LVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFK 290
           L  L++ GNPW CGC    L +WL    QR    S    C  P    G  L  L  E F+
Sbjct: 247 LEFLRLNGNPWDCGCRARSLWEWL----QRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFR 302

Query: 291 AC 292
            C
Sbjct: 303 NC 304


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 55/158 (34%), Positives = 77/158 (48%), Gaps = 3/158 (1%)

Query: 81  CPVLCTC--RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLD 138
           CP  C C  + + V C+ +RL +VP  +P +TR L L+ NRI  + PG L     L+ LD
Sbjct: 25  CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELD 84

Query: 139 LHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHP 198
           L  N++  +  G F +  RL  L L  N    +P  +F     L  +DLS N  L  +  
Sbjct: 85  LSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENK-LVILLD 143

Query: 199 QAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQI 236
             FQ L  LR L++    L F+S  A  GL  L  L +
Sbjct: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTL 181



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 56/179 (31%), Positives = 76/179 (42%), Gaps = 29/179 (16%)

Query: 108 MDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNN 167
           ++  +LS+ H  ITAVP   L     L  L+L +N +  +PRG F    RL  L L+   
Sbjct: 246 LNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLA--- 302

Query: 168 FSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEG 227
                                    L  V PQAF GL Q+R L+LS   L+ L       
Sbjct: 303 ----------------------GALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHS 340

Query: 228 LPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTE 286
           +  L TL++ GNP  C C     L W+  R +    D +L  C  P EV G  L +L +
Sbjct: 341 VNTLETLRVDGNPLACDCR----LLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPD 395



 Score = 30.0 bits (66), Expect = 3.1
 Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 1/55 (1%)

Query: 185 IDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGN 239
           ++LS N  +R ++P     L  L +LDLS   +A +   A   LP L  L++ GN
Sbjct: 59  LELSRNR-IRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGN 112


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 61/197 (30%), Positives = 88/197 (44%), Gaps = 27/197 (13%)

Query: 66  LLLAAGLMHSDAGTSCPVLCTC--RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRI--- 120
           LLL  G + S + T CP  C C  +++ V C  +R  +VP  +P +TR L L  NRI   
Sbjct: 27  LLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTL 86

Query: 121 ---------------------TAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLA 159
                                +AV PG       L+ L L +N L  +P G+F     L 
Sbjct: 87  NQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLT 146

Query: 160 HLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAF 219
            LD+S N    +   MFQ+ + L  +++  N  +   H +AF GL  L  L L    L  
Sbjct: 147 KLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISH-RAFSGLNSLEQLTLEKCNLTS 205

Query: 220 LSLEALEGLPGLVTLQI 236
           +  EAL  L GL+ L++
Sbjct: 206 IPTEALSHLHGLIVLRL 222



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 46/147 (31%), Positives = 61/147 (41%), Gaps = 5/147 (3%)

Query: 132 MELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNP 191
           + L  L + + +L  +P     H   L  L+LSYN  S +   M  E   L  I L    
Sbjct: 263 LNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQ 322

Query: 192 WLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLL 251
            L  V P AF+GL  LR L++S   L  L       +  L TL +  NP  C C     L
Sbjct: 323 -LAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCR----L 377

Query: 252 KWLRNRIQRCTADSQLAECRGPPEVEG 278
            W+  R  R   + Q   C  P  V+G
Sbjct: 378 LWVFRRRWRLNFNRQQPTCATPEFVQG 404


>gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]
          Length = 522

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 32/276 (11%)

Query: 63  LISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITA 122
           L+ LL+    +   A   CP  C C   +V C+++ L  VP +L    + L L++NRI  
Sbjct: 23  LLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGL 82

Query: 123 VPPGYL-TCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHG 181
           +   ++   + +L  L L +N++  +  G F     L  LDLS N    V   +FQE   
Sbjct: 83  LDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELK- 141

Query: 182 LVHIDLSHNPWLRRVHPQAFQGLMQLRD---------------------------LDLSY 214
           ++ + L +N  +  + P AF GL QL+                            LD+SY
Sbjct: 142 VLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSY 201

Query: 215 GGLAFLSLEALEGLPG--LVTLQIGGNPWVCGCTMEPLLK-WLRNRIQRCTADSQLAECR 271
             +  + +  +  +PG  L  + + GNP+VC C++  LL  W R              CR
Sbjct: 202 NRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCR 261

Query: 272 GPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFV 307
              +   +    L ++SF  C  ++    +  + F+
Sbjct: 262 LWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFI 297


>gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]
          Length = 522

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 32/276 (11%)

Query: 63  LISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITA 122
           L+ LL+    +   A   CP  C C   +V C+++ L  VP +L    + L L++NRI  
Sbjct: 23  LLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGL 82

Query: 123 VPPGYL-TCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHG 181
           +   ++   + +L  L L +N++  +  G F     L  LDLS N    V   +FQE   
Sbjct: 83  LDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELK- 141

Query: 182 LVHIDLSHNPWLRRVHPQAFQGLMQLRD---------------------------LDLSY 214
           ++ + L +N  +  + P AF GL QL+                            LD+SY
Sbjct: 142 VLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSY 201

Query: 215 GGLAFLSLEALEGLPG--LVTLQIGGNPWVCGCTMEPLLK-WLRNRIQRCTADSQLAECR 271
             +  + +  +  +PG  L  + + GNP+VC C++  LL  W R              CR
Sbjct: 202 NRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCR 261

Query: 272 GPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFV 307
              +   +    L ++SF  C  ++    +  + F+
Sbjct: 262 LWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFI 297


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 81.6 bits (200), Expect = 9e-16
 Identities = 63/209 (30%), Positives = 87/209 (41%), Gaps = 6/209 (2%)

Query: 80  SCPVLCTCRN----QVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQ 135
           +CP  C C      Q+ DC+ + L SVPP  P +   LSL+ NR+  +P G       LQ
Sbjct: 18  ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQ 77

Query: 136 VLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRR 195
            L L +N +  +  G       L  LDLS+N  S            L  + +  N  L  
Sbjct: 78  SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNE-LTF 136

Query: 196 VHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR 255
           +   AF+ L  LR L L++  L  L+      L  L  LQI  NP+ C C +  L  W  
Sbjct: 137 IPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWAL 196

Query: 256 NRIQRCTADSQLAECRGPPEVEGAPLFSL 284
                      +A C  P  ++G PL  L
Sbjct: 197 TTAVSIPEQDNIA-CTSPHVLKGTPLSRL 224


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 81.6 bits (200), Expect = 9e-16
 Identities = 63/209 (30%), Positives = 87/209 (41%), Gaps = 6/209 (2%)

Query: 80  SCPVLCTCRN----QVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQ 135
           +CP  C C      Q+ DC+ + L SVPP  P +   LSL+ NR+  +P G       LQ
Sbjct: 18  ACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQ 77

Query: 136 VLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRR 195
            L L +N +  +  G       L  LDLS+N  S            L  + +  N  L  
Sbjct: 78  SLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNE-LTF 136

Query: 196 VHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLR 255
           +   AF+ L  LR L L++  L  L+      L  L  LQI  NP+ C C +  L  W  
Sbjct: 137 IPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWAL 196

Query: 256 NRIQRCTADSQLAECRGPPEVEGAPLFSL 284
                      +A C  P  ++G PL  L
Sbjct: 197 TTAVSIPEQDNIA-CTSPHVLKGTPLSRL 224


>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
          Length = 504

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 57/164 (34%), Positives = 79/164 (48%), Gaps = 7/164 (4%)

Query: 80  SCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDL 139
           +CP  C C   ++ C+   L  VP +LP  T +L L+HN +  + PG+L    +L+ L L
Sbjct: 33  NCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHL 92

Query: 140 HNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVH-- 197
            +N L  L RG+F++A  L  LDLS N    +          L  + L +N   R VH  
Sbjct: 93  DHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNN---RLVHLD 149

Query: 198 PQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPG--LVTLQIGGN 239
             AF GL  L  L L    LA  S + L GL    L+TL +  N
Sbjct: 150 EHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSN 193


>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
          Length = 347

 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 60/180 (33%), Positives = 85/180 (47%), Gaps = 7/180 (3%)

Query: 112 NLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHV 171
           +L L+ NR+  +PPG L  +  L+ LDL  N L  LP  L     +L  L L  N    +
Sbjct: 168 HLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVL 227

Query: 172 PADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFL--SLEALEGLP 229
             D+      L ++ L+ N  L RV   AFQGL QL  LDLS   LA +   L A  G P
Sbjct: 228 GKDLLLPQPDLRYLFLNGNK-LARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQP 286

Query: 230 GLVT---LQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTE 286
                    I GNPW+C   +  L +WL+ +  +  + +    C GP  V+G  L ++ +
Sbjct: 287 NWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQND-TRCAGPEAVKGQTLLAVAK 345


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 36/233 (15%)

Query: 54  PGPPHPAMLLISLLLAAGLMHSDAGTSCPVLCTCR-NQVVDCSSQRLFSVPPDLPMDTRN 112
           P   H   L + L+L  G  H     +CP  C C     V C+ + L SVP  +      
Sbjct: 2   PKRAHWGALSVVLILLWG--HPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVER 59

Query: 113 LSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVP 172
           ++L  N I A+         +L++L +H N +  +P G       L     SYN    + 
Sbjct: 60  INLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVIT 119

Query: 173 ADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDL-----------SYGGLAFLS 221
               Q    L+ + + HN  +  +HPQAF GL  LR L L           ++    FL 
Sbjct: 120 GQTLQGLSNLMRLHIDHNK-IEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLD 178

Query: 222 L---------------------EALEGLPGLVTLQIGGNPWVCGCTMEPLLKW 253
                                   L  +P L  L + GNPW C C M   L+W
Sbjct: 179 YFRLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEW 231


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,903,675
Number of Sequences: 37866
Number of extensions: 697940
Number of successful extensions: 4294
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 196
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 2405
Number of HSP's gapped (non-prelim): 805
length of query: 341
length of database: 18,247,518
effective HSP length: 103
effective length of query: 238
effective length of database: 14,347,320
effective search space: 3414662160
effective search space used: 3414662160
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.