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Search of human proteins with 13376339
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13376339 plasticity-related protein 2 [Homo sapiens]
(746 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13376339 plasticity-related protein 2 [Homo sapiens] 1496 0.0
gi|33636722 plasticity related gene 1 [Homo sapiens] 577 e-164
gi|46877066 plasticity related gene 3 [Homo sapiens] 175 1e-43
gi|46877064 plasticity related gene 3 [Homo sapiens] 175 1e-43
gi|82659094 phosphatidic acid phosphatase type 2d isoform 1 [Hom... 159 1e-38
gi|61102719 phosphatidic acid phosphatase type 2d isoform 2 [Hom... 159 1e-38
gi|12232395 lipid phosphate phosphatase-related protein type 2 [... 142 1e-33
gi|4505977 phosphatidic acid phosphatase type 2C isoform 1 [Homo... 80 9e-15
gi|29171738 phosphatidic acid phosphatase type 2A isoform 2 [Hom... 79 2e-14
gi|29171740 phosphatidic acid phosphatase type 2B [Homo sapiens] 77 4e-14
gi|29171742 phosphatidic acid phosphatase type 2B [Homo sapiens] 77 4e-14
gi|29171736 phosphatidic acid phosphatase type 2A isoform 1 [Hom... 76 1e-13
gi|29171747 phosphatidic acid phosphatase type 2C isoform 3 [Hom... 75 3e-13
gi|29171745 phosphatidic acid phosphatase type 2C isoform 2 [Hom... 65 3e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 53 9e-07
gi|48255889 protein kinase C substrate 80K-H isoform 1 [Homo sap... 53 1e-06
gi|154759293 cysteine-rich hydrophobic domain 1 [Homo sapiens] 52 3e-06
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 51 3e-06
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 50 6e-06
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 50 6e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 50 6e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 50 6e-06
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 50 6e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 50 6e-06
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 50 6e-06
gi|38372931 brevican isoform 2 [Homo sapiens] 50 6e-06
gi|4504425 high-mobility group box 1 [Homo sapiens] 49 1e-05
gi|118600967 shroom family member 4 [Homo sapiens] 49 2e-05
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 49 2e-05
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 49 2e-05
>gi|13376339 plasticity-related protein 2 [Homo sapiens]
Length = 746
Score = 1496 bits (3873), Expect = 0.0
Identities = 746/746 (100%), Positives = 746/746 (100%)
Query: 1 MISTKEKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLS 60
MISTKEKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLS
Sbjct: 1 MISTKEKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLS 60
Query: 61 MPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGG 120
MPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGG
Sbjct: 61 MPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGG 120
Query: 121 CNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVN 180
CNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVN
Sbjct: 121 CNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVN 180
Query: 181 PYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSL 240
PYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSL
Sbjct: 181 PYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSL 240
Query: 241 TPTPMPQMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAG 300
TPTPMPQMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAG
Sbjct: 241 TPTPMPQMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAG 300
Query: 301 IAAYLACHAVGNFQAPPAEKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRL 360
IAAYLACHAVGNFQAPPAEKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRL
Sbjct: 301 IAAYLACHAVGNFQAPPAEKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRL 360
Query: 361 EGAPRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRH 420
EGAPRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRH
Sbjct: 361 EGAPRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRH 420
Query: 421 MTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEE 480
MTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEE
Sbjct: 421 MTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEE 480
Query: 481 EEEEEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSG 540
EEEEEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSG
Sbjct: 481 EEEEEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSG 540
Query: 541 AGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSP 600
AGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSP
Sbjct: 541 AGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSP 600
Query: 601 SDRDSASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGA 660
SDRDSASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGA
Sbjct: 601 SDRDSASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGA 660
Query: 661 KPPGVSPGSSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGG 720
KPPGVSPGSSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGG
Sbjct: 661 KPPGVSPGSSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGG 720
Query: 721 LGLAEREAEAEAEGYFRKMQARRFPD 746
LGLAEREAEAEAEGYFRKMQARRFPD
Sbjct: 721 LGLAEREAEAEAEGYFRKMQARRFPD 746
>gi|33636722 plasticity related gene 1 [Homo sapiens]
Length = 763
Score = 577 bits (1488), Expect = e-164
Identities = 350/750 (46%), Positives = 455/750 (60%), Gaps = 73/750 (9%)
Query: 2 ISTKE--KNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTL 59
+S KE K K+ KDS+TLLPCFYFVELPI+ASS+VSLYFLELTD+FKP GF CYDR+L
Sbjct: 49 MSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSL 108
Query: 60 SMPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAG 119
SMPY+E +E IP LMLLSLAFA PA +IMV EG+LYC S+ R G G E +INAG
Sbjct: 109 SMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSK---RRNG-VGLEPNINAG 164
Query: 120 GCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEV 179
GCNFNSFLRR VRFVGVHVFGLC+TAL+TD+IQL+TGY P+FLTVCKPNYT L SC+
Sbjct: 165 GCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKE 224
Query: 180 NPYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPS 239
N YI +DICSG D+ I S RK+FPSQHATL+AFAAVYVS
Sbjct: 225 NSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVS-------------------- 264
Query: 240 LTPTPMPQMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGA 299
MYFNS ++D++KLLKP+LVF F I +CGLT+ITQY++HPVDVY GFLIG
Sbjct: 265 --------MYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGG 316
Query: 300 GIAAYLACHAVGNFQAPPAEKPAAPAPAKDALRALTQRGHD--SVYQQNKSVSTDELGPP 357
GIA YL +AVGNF P+++ + +DALR+LT D + S+D +
Sbjct: 317 GIALYLGLYAVGNFL--PSDE--SMFQHRDALRSLTDLNQDPNRLLSAKNGSSSDGI--- 369
Query: 358 GRLEGAPRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPA 417
EG R+ +SL +LKRA+ DV+++ PRSPM KENMVTFS+TLPRA+ PS++DP
Sbjct: 370 AHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKENMVTFSNTLPRANTPSVEDPV 429
Query: 418 RRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLP-DDASPGHLRAPAEPMAEEEEEEED 476
RR+ +IH +D++RSKQL+++WK K+ E R L L + PG ++P + E
Sbjct: 430 RRNASIHASMDSARSKQLLTQWKNKN-ESRKLSLQVIEPEPG--QSPPRSI----EMRSS 482
Query: 477 EEEEEEEEEEEDEGPAPPSLYPTVQARPGL------GPRVILPPRAGPPPLVHIPEEGAQ 530
E + GP L A PG GPRV + R G LVHIPEE Q
Sbjct: 483 SEPSRVGVNGDHHGPGNQYLKIQPGAVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEE-TQ 541
Query: 531 TGAGLSPKSGAGVRAKWLMMAEKSGAA--VANPPRLLQVIAMSKAPGAPGPKAAETASSS 588
SPKS + RAKWL AEK+ A + PR++QVIAMSK G T S+
Sbjct: 542 ENISTSPKS-SSARAKWLKAAEKTVACNRSNSQPRIMQVIAMSKQQGVLQSSPKNTEGST 600
Query: 589 SASSDSSQYRSPSDRDSASIVTIDAHAPHH-PVVHLSA----GGAPWEWKAAGGGAKAEA 643
+ + S +Y++ +D + + IV ++AH ++ P++ + + G W+WKA G+ +
Sbjct: 601 VSCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSTEGEGSGSWKWKAPEKGSLRQT 660
Query: 644 DGGYELGDLARGFRG--GAKPPGVSPGSSVSDVDQEEPRFGAVATVNLATGEGLPPLGAA 701
YEL DL R K S S++D E + T+ + EG +G+
Sbjct: 661 ---YELNDLNRDSESCESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEG-SEIGSE 716
Query: 702 DGALGPGSRESTLRRHAGGLGLAEREAEAE 731
++ SR+STLRR + + ER E
Sbjct: 717 TLSIS-SSRDSTLRRKGNIILIPERSNSPE 745
>gi|46877066 plasticity related gene 3 [Homo sapiens]
Length = 325
Score = 175 bits (444), Expect = 1e-43
Identities = 117/348 (33%), Positives = 173/348 (49%), Gaps = 40/348 (11%)
Query: 14 SMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEE--LI 71
S +++PCF FVEL I+A +++ Y+ E TD F+ GF C D L PY T EE +
Sbjct: 10 SYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVHIQGFFCQDGDLMKPYPGTEEESFIT 69
Query: 72 PLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGGCNFNSFLRRTV 131
PL++ LA A P A I + E +Y ++S R A + + C N LRR +
Sbjct: 70 PLVLYCVLA-ATPTAIIFIGEISMYFIKST---RESLIAQEKTILTGECCYLNPLLRRII 125
Query: 132 RFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGH 191
RF GV FGL AT + + Q+ TG+ TP+FLTVCKPNYT +IC+G
Sbjct: 126 RFTGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSADCQAHHQFINNGNICTG- 184
Query: 192 DIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQMYFN 251
D+ I AR++FPS+HA LS ++A+Y + MY
Sbjct: 185 DLEVIEKARRSFPSKHAALSIYSALYAT----------------------------MYIT 216
Query: 252 SVI-SDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAV 310
S I + +++L KP+L A + GL ++++YR+H DV AGF++G +A +L V
Sbjct: 217 STIKTKSSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVV 276
Query: 311 GNFQ----APPAEKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDEL 354
NF+ +P KP P + +++ QN S S E+
Sbjct: 277 HNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEV 324
>gi|46877064 plasticity related gene 3 [Homo sapiens]
Length = 325
Score = 175 bits (444), Expect = 1e-43
Identities = 117/348 (33%), Positives = 173/348 (49%), Gaps = 40/348 (11%)
Query: 14 SMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEE--LI 71
S +++PCF FVEL I+A +++ Y+ E TD F+ GF C D L PY T EE +
Sbjct: 10 SYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVHIQGFFCQDGDLMKPYPGTEEESFIT 69
Query: 72 PLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGGCNFNSFLRRTV 131
PL++ LA A P A I + E +Y ++S R A + + C N LRR +
Sbjct: 70 PLVLYCVLA-ATPTAIIFIGEISMYFIKST---RESLIAQEKTILTGECCYLNPLLRRII 125
Query: 132 RFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGH 191
RF GV FGL AT + + Q+ TG+ TP+FLTVCKPNYT +IC+G
Sbjct: 126 RFTGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVCKPNYTSADCQAHHQFINNGNICTG- 184
Query: 192 DIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQMYFN 251
D+ I AR++FPS+HA LS ++A+Y + MY
Sbjct: 185 DLEVIEKARRSFPSKHAALSIYSALYAT----------------------------MYIT 216
Query: 252 SVI-SDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAV 310
S I + +++L KP+L A + GL ++++YR+H DV AGF++G +A +L V
Sbjct: 217 STIKTKSSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVV 276
Query: 311 GNFQ----APPAEKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDEL 354
NF+ +P KP P + +++ QN S S E+
Sbjct: 277 HNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEV 324
>gi|82659094 phosphatidic acid phosphatase type 2d isoform 1 [Homo
sapiens]
Length = 321
Score = 159 bits (401), Expect = 1e-38
Identities = 105/313 (33%), Positives = 154/313 (49%), Gaps = 41/313 (13%)
Query: 15 MTLLPC-----FYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEE 69
M LLP + ++ I+A +++ Y+ E TD F GF C+D PY +
Sbjct: 1 MPLLPAALTSSMLYFQMVIMAGTVMLAYYFEYTDTFTVNVQGFFCHDSAYRKPYPGPEDS 60
Query: 70 -LIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGGCNF-NSFL 127
+P ++L SLA P I+V E ++CLQ E +I G C + N +
Sbjct: 61 SAVPPVLLYSLAAGVPVLVIIVGETAVFCLQLA----TRDFENQEKTILTGDCCYINPLV 116
Query: 128 RRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDI 187
RRTVRF+G++ FGL AT + + Q+ TG P FL +CKPNYT LG ++
Sbjct: 117 RRTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEA 176
Query: 188 CSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQ 247
C+G+ I+ ARKTFPS+ A LS +AA+Y++
Sbjct: 177 CTGNP-DLIMRARKTFPSKEAALSVYAAMYLT---------------------------- 207
Query: 248 MYF-NSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLA 306
MY N++ + T+L KP+L A + GL ++ +YR+H DV AGFL+G IA +L
Sbjct: 208 MYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Query: 307 CHAVGNFQAPPAE 319
V NF+ AE
Sbjct: 268 VCVVNNFKGRQAE 280
>gi|61102719 phosphatidic acid phosphatase type 2d isoform 2 [Homo
sapiens]
Length = 316
Score = 159 bits (401), Expect = 1e-38
Identities = 105/313 (33%), Positives = 154/313 (49%), Gaps = 41/313 (13%)
Query: 15 MTLLPC-----FYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEE 69
M LLP + ++ I+A +++ Y+ E TD F GF C+D PY +
Sbjct: 1 MPLLPAALTSSMLYFQMVIMAGTVMLAYYFEYTDTFTVNVQGFFCHDSAYRKPYPGPEDS 60
Query: 70 -LIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGGCNF-NSFL 127
+P ++L SLA P I+V E ++CLQ E +I G C + N +
Sbjct: 61 SAVPPVLLYSLAAGVPVLVIIVGETAVFCLQLA----TRDFENQEKTILTGDCCYINPLV 116
Query: 128 RRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDI 187
RRTVRF+G++ FGL AT + + Q+ TG P FL +CKPNYT LG ++
Sbjct: 117 RRTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEA 176
Query: 188 CSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQ 247
C+G+ I+ ARKTFPS+ A LS +AA+Y++
Sbjct: 177 CTGNP-DLIMRARKTFPSKEAALSVYAAMYLT---------------------------- 207
Query: 248 MYF-NSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLA 306
MY N++ + T+L KP+L A + GL ++ +YR+H DV AGFL+G IA +L
Sbjct: 208 MYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 267
Query: 307 CHAVGNFQAPPAE 319
V NF+ AE
Sbjct: 268 VCVVNNFKGRQAE 280
>gi|12232395 lipid phosphate phosphatase-related protein type 2
[Homo sapiens]
Length = 343
Score = 142 bits (358), Expect = 1e-33
Identities = 105/324 (32%), Positives = 156/324 (48%), Gaps = 43/324 (13%)
Query: 12 KDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNE-EL 70
K S +++PCF FVE ++ I+ Y LE TD GF CYD T + PY
Sbjct: 9 KRSFSIIPCFVFVESVLLGIVILLAYRLEFTDTLPVHTQGFFCYDSTYAKPYPGPEAASR 68
Query: 71 IPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGGC-NFNSFLRR 129
+P ++ +L A P +I++ E + + P E +I +G C F+ +RR
Sbjct: 69 VPPALVYALVTAGPTLTILLGELARAFFPAP---PSAVPVIGESTIVSGACCRFSPPVRR 125
Query: 130 TVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLG----TSCEVNP--YI 183
VRF+GV+ FGL T + + Q+ TG TP FL+VC+PNYT LG + P ++
Sbjct: 126 LVRFLGVYSFGLFTTTIFANAGQVVTGNPTPHFLSVCRPNYTALGCLPPSPDRPGPDRFV 185
Query: 184 T-QDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTP 242
T Q C+G + +AR+ FP + A L A+A Y +
Sbjct: 186 TDQGACAGSP-SLVAAARRAFPCKDAALCAYAVTYTA----------------------- 221
Query: 243 TPMPQMYFNSVIS-DTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGI 301
MY V ++L+KP L A A + G+ ++ +YR+H DV AGFL GA I
Sbjct: 222 -----MYVTLVFRVKGSRLVKPSLCLALLCPAFLVGVVRVAEYRNHWSDVLAGFLTGAAI 276
Query: 302 AAYLACHAVGNFQA-PPAEKPAAP 324
A +L V NFQ+ PP+ + +P
Sbjct: 277 ATFLVTCVVHNFQSRPPSGRRLSP 300
>gi|4505977 phosphatidic acid phosphatase type 2C isoform 1 [Homo
sapiens]
Length = 288
Score = 79.7 bits (195), Expect = 9e-15
Identities = 73/298 (24%), Positives = 128/298 (42%), Gaps = 52/298 (17%)
Query: 23 FVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEELIPLLMLLSLAFA 82
FV L ++ + SL F LT + P K GF C D ++ PY + I ++ +
Sbjct: 7 FVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIRYPY---RPDTITHGLMAGVTIT 63
Query: 83 APAASIMVAEGMLYCLQS-RLWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGL 141
A I+V+ G Y + + RL+ R+ +FN+++ + +G +FG
Sbjct: 64 ATV--ILVSAGEAYLVYTDRLYSRS---------------DFNNYVAAVYKVLGTFLFGA 106
Query: 142 CATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARK 201
+ +TD+ + G P FL VC P+++ + S V + +C G+ + AR
Sbjct: 107 AVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQ---LEKVCRGNPAD-VTEARL 162
Query: 202 TFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQMYFNSVISDTTKLL 261
+F S H++ + V++++ QA L + +LL
Sbjct: 163 SFYSGHSSFGMYCMVFLALY------VQARLCWK---------------------WARLL 195
Query: 262 KPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAE 319
+P + F A G T+++ Y+ H DV G L GA +AA C+ F+A P +
Sbjct: 196 RPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQ 253
>gi|29171738 phosphatidic acid phosphatase type 2A isoform 2 [Homo
sapiens]
Length = 285
Score = 78.6 bits (192), Expect = 2e-14
Identities = 65/311 (20%), Positives = 134/311 (43%), Gaps = 63/311 (20%)
Query: 6 EKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVE 65
+K ++P ++ +L C +P+ + +Y P + GF C D +++ PY
Sbjct: 3 DKTRLPYVALDVL-CVLLASMPMAVLKLGQIY---------PFQRGFFCKDNSINYPY-- 50
Query: 66 TNEELIPLLMLLSLAFAAPAASIMVAEGM-LYCLQSRLWGRAGGPAGAEGSINAGGCNFN 124
++ + +L+ + P +SI++ E + +YC +++ N
Sbjct: 51 -HDSTVTSTVLILVGVGLPISSIILGETLSVYC----------------NLLHSNSFIRN 93
Query: 125 SFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYIT 184
+++ + +G +FG A+ +TD+ + + G P FL VC P+++ + S + YI
Sbjct: 94 NYIATIYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIE 150
Query: 185 QDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTP 244
IC G + + R +F S H++ S + ++V+
Sbjct: 151 YYICRG-NAERVKEGRLSFYSGHSSFSMYCMLFVA------------------------- 184
Query: 245 MPQMYFNS-VISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAA 303
+Y + + D +LL+P L F + GL++++ Y+ H DV G + GA +A
Sbjct: 185 ---LYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAI 241
Query: 304 YLACHAVGNFQ 314
+A + F+
Sbjct: 242 LVAVYVSDFFK 252
>gi|29171740 phosphatidic acid phosphatase type 2B [Homo sapiens]
Length = 311
Score = 77.4 bits (189), Expect = 4e-14
Identities = 73/290 (25%), Positives = 120/290 (41%), Gaps = 49/290 (16%)
Query: 42 TDLFKPAKVGFQCYDRTLSMPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSR 101
T KP GF C D ++ P ++T E + ++ A A + + G Y +
Sbjct: 56 TSTIKPYHRGFYCNDESIKYP-LKTGETINDAVLC---AVGIVIAILAIITGEFYRIYYL 111
Query: 102 LWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPF 161
R+ +I N ++ + VG +FG + TD+ +++ G P
Sbjct: 112 KKSRS--------TIQ------NPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPH 157
Query: 162 FLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVS 221
FL+VC P+++ + S YI C G D + ARK+F S HA+ S + +Y+ +
Sbjct: 158 FLSVCNPDFSQINCS---EGYIQNYRCRGDD-SKVQEARKSFFSGHASFSMYTMLYLVLY 213
Query: 222 PAPHCPSQALLLTRGEPSLTPTPMPQMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQI 281
QA RG +LL+P+L F + A GL+++
Sbjct: 214 ------LQARFTWRG---------------------ARLLRPLLQFTLIMMAFYTGLSRV 246
Query: 282 TQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAEKPAAPAPAKDAL 331
+ ++ HP DV AGF GA +A + F+ APA K+ L
Sbjct: 247 SDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEIL 296
>gi|29171742 phosphatidic acid phosphatase type 2B [Homo sapiens]
Length = 311
Score = 77.4 bits (189), Expect = 4e-14
Identities = 73/290 (25%), Positives = 120/290 (41%), Gaps = 49/290 (16%)
Query: 42 TDLFKPAKVGFQCYDRTLSMPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSR 101
T KP GF C D ++ P ++T E + ++ A A + + G Y +
Sbjct: 56 TSTIKPYHRGFYCNDESIKYP-LKTGETINDAVLC---AVGIVIAILAIITGEFYRIYYL 111
Query: 102 LWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPF 161
R+ +I N ++ + VG +FG + TD+ +++ G P
Sbjct: 112 KKSRS--------TIQ------NPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPH 157
Query: 162 FLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSVS 221
FL+VC P+++ + S YI C G D + ARK+F S HA+ S + +Y+ +
Sbjct: 158 FLSVCNPDFSQINCS---EGYIQNYRCRGDD-SKVQEARKSFFSGHASFSMYTMLYLVLY 213
Query: 222 PAPHCPSQALLLTRGEPSLTPTPMPQMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQI 281
QA RG +LL+P+L F + A GL+++
Sbjct: 214 ------LQARFTWRG---------------------ARLLRPLLQFTLIMMAFYTGLSRV 246
Query: 282 TQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAEKPAAPAPAKDAL 331
+ ++ HP DV AGF GA +A + F+ APA K+ L
Sbjct: 247 SDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEIL 296
>gi|29171736 phosphatidic acid phosphatase type 2A isoform 1 [Homo
sapiens]
Length = 284
Score = 76.3 bits (186), Expect = 1e-13
Identities = 65/294 (22%), Positives = 123/294 (41%), Gaps = 53/294 (18%)
Query: 23 FVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEELIPLLMLLSLAFA 82
+V L ++ + L F LT P + G C D ++ PY E+ IP +L +
Sbjct: 9 YVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDESIKYPY---KEDTIPYALLGGIIIP 65
Query: 83 APAASIMVAEGM-LYCLQSRLWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGL 141
I++ E + +YC +++ N+++ + +G +FG
Sbjct: 66 FSIIVIILGETLSVYC----------------NLLHSNSFIRNNYIATIYKAIGTFLFGA 109
Query: 142 CATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARK 201
A+ +TD+ + + G P FL VC P+++ + S + YI IC G + + R
Sbjct: 110 AASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIEYYICRG-NAERVKEGRL 165
Query: 202 TFPSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQMYFNS-VISDTTKL 260
+F S H++ S + ++V+ +Y + + D +L
Sbjct: 166 SFYSGHSSFSMYCMLFVA----------------------------LYLQARMKGDWARL 197
Query: 261 LKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQ 314
L+P L F + GL++++ Y+ H DV G + GA +A +A + F+
Sbjct: 198 LRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYVSDFFK 251
>gi|29171747 phosphatidic acid phosphatase type 2C isoform 3 [Homo
sapiens]
Length = 309
Score = 74.7 bits (182), Expect = 3e-13
Identities = 70/286 (24%), Positives = 122/286 (42%), Gaps = 52/286 (18%)
Query: 35 SLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEELIPLLMLLSLAFAAPAASIMVAEGM 94
SL F LT + P K GF C D ++ PY + I ++ + A I+V+ G
Sbjct: 40 SLPFAILTLVNAPYKRGFYCGDDSIRYPY---RPDTITHGLMAGVTITATV--ILVSAGE 94
Query: 95 LYCLQS-RLWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQL 153
Y + + RL+ R+ +FN+++ + +G +FG + +TD+ +
Sbjct: 95 AYLVYTDRLYSRS---------------DFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKY 139
Query: 154 ATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARKTFPSQHATLSAF 213
G P FL VC P+++ + S V + +C G+ + AR +F S H++ +
Sbjct: 140 MIGRLRPNFLAVCDPDWSRVNCSVYVQ---LEKVCRGNPAD-VTEARLSFYSGHSSFGMY 195
Query: 214 AAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQMYFNSVISDTTKLLKPILVFAFAIAA 273
V++++ QA L + +LL+P + F A
Sbjct: 196 CMVFLALY------VQARLCWK---------------------WARLLRPTVQFFLVAFA 228
Query: 274 GVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAE 319
G T+++ Y+ H DV G L GA +AA C+ F+A P +
Sbjct: 229 LYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQ 274
>gi|29171745 phosphatidic acid phosphatase type 2C isoform 2 [Homo
sapiens]
Length = 232
Score = 64.7 bits (156), Expect = 3e-10
Identities = 56/236 (23%), Positives = 101/236 (42%), Gaps = 47/236 (19%)
Query: 85 AASIMVAEGMLYCLQS-RLWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGLCA 143
A I+V+ G Y + + RL+ R+ +FN+++ + +G +FG
Sbjct: 8 ATVILVSAGEAYLVYTDRLYSRS---------------DFNNYVAAVYKVLGTFLFGAAV 52
Query: 144 TALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARKTF 203
+ +TD+ + G P FL VC P+++ + S V + +C G+ + AR +F
Sbjct: 53 SQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQ---LEKVCRGNPAD-VTEARLSF 108
Query: 204 PSQHATLSAFAAVYVSVSPAPHCPSQALLLTRGEPSLTPTPMPQMYFNSVISDTTKLLKP 263
S H++ + V++++ QA L + +LL+P
Sbjct: 109 YSGHSSFGMYCMVFLALY------VQARLCWK---------------------WARLLRP 141
Query: 264 ILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAE 319
+ F A G T+++ Y+ H DV G L GA +AA C+ F+A P +
Sbjct: 142 TVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQ 197
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 53.1 bits (126), Expect = 9e-07
Identities = 46/153 (30%), Positives = 65/153 (42%), Gaps = 25/153 (16%)
Query: 469 EEEEEEEDEEEEEEEEEEED-----------EGPAPPSLYPTVQARPGLGPRVILPPRAG 517
EEEEEEEDEEEEEE EE ED EG PP P P P+V P
Sbjct: 943 EEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPE 1002
Query: 518 PPPLVHI------PEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMS 571
P L+ + E GA T L+P++ + ++ + E A PP+ L +
Sbjct: 1003 PGLLLEVEEPGTEEERGADTAPTLAPEA---LPSQGEVEREGESPAAGPPPQEL----VE 1055
Query: 572 KAPGAPGPKAAETASSSSASSDSSQYRSPSDRD 604
+ P AP P E + + +P++ +
Sbjct: 1056 EEPSAP-PTLLEEETEDGSDKVQPPPETPAEEE 1087
Score = 42.7 bits (99), Expect = 0.001
Identities = 19/21 (90%), Positives = 21/21 (100%)
Query: 469 EEEEEEEDEEEEEEEEEEEDE 489
EEEEEEE+EEEEEEEEEEE+E
Sbjct: 888 EEEEEEEEEEEEEEEEEEEEE 908
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/20 (95%), Positives = 20/20 (100%)
Query: 469 EEEEEEEDEEEEEEEEEEED 488
EEEEEEE+EEEEEEEEEEED
Sbjct: 890 EEEEEEEEEEEEEEEEEEED 909
Score = 42.0 bits (97), Expect = 0.002
Identities = 18/22 (81%), Positives = 22/22 (100%)
Query: 468 AEEEEEEEDEEEEEEEEEEEDE 489
++EEEEEE+EEEEEEEEEEE+E
Sbjct: 886 SDEEEEEEEEEEEEEEEEEEEE 907
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/21 (85%), Positives = 21/21 (100%)
Query: 469 EEEEEEEDEEEEEEEEEEEDE 489
EEEEEEE+EEEEEEEEEEE++
Sbjct: 889 EEEEEEEEEEEEEEEEEEEED 909
Score = 41.2 bits (95), Expect = 0.004
Identities = 20/39 (51%), Positives = 28/39 (71%)
Query: 451 LPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDE 489
L +D + ++ + E EEEEEEE+EEEEEEEEE+ +E
Sbjct: 874 LEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEE 912
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/25 (76%), Positives = 21/25 (84%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEE+ EEEEEDE
Sbjct: 893 EEEEEEEEEEEEEEEEDFEEEEEDE 917
Score = 38.9 bits (89), Expect = 0.018
Identities = 18/25 (72%), Positives = 21/25 (84%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEEEEEE+ E+E
Sbjct: 889 EEEEEEEEEEEEEEEEEEEEDFEEE 913
Score = 37.7 bits (86), Expect = 0.039
Identities = 17/25 (68%), Positives = 21/25 (84%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEE+ EEEEE++E
Sbjct: 894 EEEEEEEEEEEEEEEDFEEEEEDEE 918
Score = 37.7 bits (86), Expect = 0.039
Identities = 17/25 (68%), Positives = 21/25 (84%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EE+ EEEEE+E+E
Sbjct: 895 EEEEEEEEEEEEEEDFEEEEEDEEE 919
Score = 36.6 bits (83), Expect = 0.087
Identities = 18/40 (45%), Positives = 22/40 (55%)
Query: 450 GLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDE 489
G P P L + +EE+EEEEEEEEEEE+E
Sbjct: 864 GTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEE 903
>gi|48255889 protein kinase C substrate 80K-H isoform 1 [Homo
sapiens]
Length = 528
Score = 52.8 bits (125), Expect = 1e-06
Identities = 29/53 (54%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Query: 452 PDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTVQARP 504
P + P +P E EEEEEEE+EEE EEEEEEED APP L P A P
Sbjct: 300 PKEEQPPVPSSPTEE--EEEEEEEEEEEAEEEEEEEDSEEAPPPLSPPQPASP 350
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 11/87 (12%)
Query: 454 DASPGHLRAPAEPMAEEEEEEED-------EEEEEEEEEEEDEGPAPPSLYPTVQARPGL 506
+A P L AP+ P E +EE+ EEEEEEEEEEE+E + +A P L
Sbjct: 283 EALPTDLPAPSAPDLTEPKEEQPPVPSSPTEEEEEEEEEEEEEAEEEEEEEDSEEAPPPL 342
Query: 507 GPRVILPPRAGPPPLVHIPEEGAQTGA 533
P P A P +P QT A
Sbjct: 343 SP----PQPASPAEEDKMPPYDEQTQA 365
>gi|154759293 cysteine-rich hydrophobic domain 1 [Homo sapiens]
Length = 224
Score = 51.6 bits (122), Expect = 3e-06
Identities = 28/60 (46%), Positives = 36/60 (60%), Gaps = 1/60 (1%)
Query: 436 ISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMA-EEEEEEEDEEEEEEEEEEEDEGPAPP 494
ISE +++ E +S + P + EEEEEEE+EEEEEEEEEEE+E P PP
Sbjct: 14 ISELEEEEEEEAATSSSSPSSSSSVSGPDDDEEDEEEEEEEEEEEEEEEEEEEEEAPPPP 73
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 51.2 bits (121), Expect = 3e-06
Identities = 71/308 (23%), Positives = 115/308 (37%), Gaps = 47/308 (15%)
Query: 314 QAPPAEKPAAPA------PAKDALRAL----TQRGHDSVYQQNKSVSTDELGPPGRLEGA 363
Q PPA+K A PA P K A +A ++ D ++++ + G + + A
Sbjct: 98 QGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAA 157
Query: 364 PRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTI 423
P + K+S +S D P++ K VT +A + PAR I
Sbjct: 158 KAPPKKAKSSDSDSDSSSEDEP---PKNQKPKITPVTV-----KAQTKAPPKPARAAPKI 209
Query: 424 -HVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGH---LRAPAEPMAEEEEEEEDEEE 479
+ +S S S S E + P P +AP + + E+
Sbjct: 210 ANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED 269
Query: 480 EEEEEEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKS 539
+EEEE + P ++ +PG P +PP + PPP + G P
Sbjct: 270 SSSDEEEEQKKP--------MKNKPG--PYSSVPPPSAPPP---------KKSLGTQPPK 310
Query: 540 GAGVRAKWLMMAEKSG------AAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSD 593
A + + + +E S + P V++ + P KAAE++S SS S
Sbjct: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDS 370
Query: 594 SSQYRSPS 601
S +PS
Sbjct: 371 SEDDEAPS 378
Score = 43.1 bits (100), Expect = 0.001
Identities = 50/246 (20%), Positives = 87/246 (35%), Gaps = 44/246 (17%)
Query: 377 LKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLI 436
LK A V L P+AK+ +AS+ +D + + P
Sbjct: 58 LKSAKVPERKLQANGPVAKK-------AKKKASSSDSEDSSEEEEEVQGP---------- 100
Query: 437 SEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEG------ 490
K+ ++ + +GLP PG A A + EE +D++EE+++++ +G
Sbjct: 101 -PAKKAAVPAKRVGLP----PGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAK 155
Query: 491 --PAPPSL--------------YPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAG 534
APP P +P + P + PP + A A
Sbjct: 156 AAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAA 215
Query: 535 LSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDS 594
S S + + EK+ A QV+A + A P ++S S+S +
Sbjct: 216 SSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEE 275
Query: 595 SQYRSP 600
+ + P
Sbjct: 276 EEQKKP 281
Score = 30.0 bits (66), Expect = 8.2
Identities = 44/209 (21%), Positives = 76/209 (36%), Gaps = 29/209 (13%)
Query: 315 APPAEKPAAPAPAKDALRAL--TQRGHDSVYQQNKSVSTDELGPP-----GRLEGAPRPV 367
APP +K P K A+ + DS + + S S +E PP + P P
Sbjct: 297 APPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSS-SEEEKKPPTKAVVSKATTKPPPA 355
Query: 368 AREKTSLGSLKRASVDVDLLAPRSPMA-------KENMVTFSHTLPRASAPSLDDPARRH 420
+ S + D AP P K + T S + A+AP +
Sbjct: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK 415
Query: 421 MTIHVPLDAS-----------RSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAE 469
+ +S ++K++++ K K+ L LP +P R +
Sbjct: 416 LLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDS 475
Query: 470 EEEEEEDEEEEE---EEEEEEDEGPAPPS 495
EEE+E+ + +++ ++ G A PS
Sbjct: 476 SSSEEEEEKTSKSAVKKKPQKVAGGAAPS 504
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 50.4 bits (119), Expect = 6e-06
Identities = 44/151 (29%), Positives = 60/151 (39%), Gaps = 26/151 (17%)
Query: 471 EEEEEDEEEEEEEEEEEDEGPAPPSLYPTVQARPGLGP-----------------RVILP 513
EEEEE+EEEEEEEEEEE++ PA + T A P P RV
Sbjct: 1022 EEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQL 1081
Query: 514 PRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLL----QVIA 569
P PP ++P G + + A M E + A+ A L+ Q+++
Sbjct: 1082 PTLPPPMPWNLP-----AGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILS 1136
Query: 570 MSKAPGAPGPKAAETASSSSASSDSSQYRSP 600
K P + G A +S S Y P
Sbjct: 1137 HRKPPSSLGMTPAPVPTSLGLPPGPSSYLLP 1167
Score = 45.8 bits (107), Expect = 1e-04
Identities = 20/25 (80%), Positives = 23/25 (92%)
Query: 466 PMAEEEEEEEDEEEEEEEEEEEDEG 490
P EEEEEEE+EEEEEEE+EEE+EG
Sbjct: 265 PSPEEEEEEEEEEEEEEEDEEEEEG 289
Score = 43.5 bits (101), Expect = 7e-04
Identities = 20/36 (55%), Positives = 24/36 (66%)
Query: 452 PDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEE 487
P ++P P EEEEEEE+EEEEE+EEEEE
Sbjct: 253 PTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEE 288
Score = 37.7 bits (86), Expect = 0.039
Identities = 17/27 (62%), Positives = 19/27 (70%)
Query: 463 PAEPMAEEEEEEEDEEEEEEEEEEEDE 489
P+ EEE+EEEEEEEEEEEDE
Sbjct: 258 PSSSAGTPSPEEEEEEEEEEEEEEEDE 284
Score = 33.5 bits (75), Expect = 0.74
Identities = 23/58 (39%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 426 PLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEE 483
P D + S E K E G +S G E EEEEEEE+E+EEEEE
Sbjct: 233 PTDEAYSPPPAPEQKYDPFEPTGSN--PSSSAGTPSPEEEEEEEEEEEEEEEDEEEEE 288
Score = 31.6 bits (70), Expect = 2.8
Identities = 14/28 (50%), Positives = 16/28 (57%)
Query: 473 EEEDEEEEEEEEEEEDEGPAPPSLYPTV 500
EEEDE + EE ED G PP PT+
Sbjct: 2 EEEDESRGKTEESGEDRGDGPPDRDPTL 29
Score = 30.0 bits (66), Expect = 8.2
Identities = 13/26 (50%), Positives = 17/26 (65%)
Query: 464 AEPMAEEEEEEEDEEEEEEEEEEEDE 489
+ P + +EEEEEEEEEEE+E
Sbjct: 256 SNPSSSAGTPSPEEEEEEEEEEEEEE 281
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 50.4 bits (119), Expect = 6e-06
Identities = 80/317 (25%), Positives = 119/317 (37%), Gaps = 42/317 (13%)
Query: 310 VGNFQAPPAEKP---AAPAPAKDALRALTQ-----RGHDSVYQQNKSVSTDELGPPGRLE 361
VG AP E P AAPAP A+ + R DS +S S +E +
Sbjct: 294 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 353
Query: 362 G-APRPVAREKTSLGSLKRASVDVDLLAPRS--PMAKENMVTFSHTLPRASAPSLDDPAR 418
G AP+ A + S ++ + PR P A + V R+S+ D
Sbjct: 354 GKAPQVRAASAPAKESPRKGAAPAP---PRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 410
Query: 419 RHMTIHV----PLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEE 474
++ PL S + S L G+G G PG + PA P A+ + E
Sbjct: 411 ALAAMNAAQVKPLGKSPQVKPASTMGMGPL-GKGAG---PVPPGKV-GPATPSAQVGKWE 465
Query: 475 EDEEEEEEEEEEEDEGPAPPSLYPT--------VQARPGLGPRVILPPRAGP-------- 518
ED E EE + +G P ++ P +QA+P P P +AGP
Sbjct: 466 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 525
Query: 519 PPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAP---G 575
P+ + + + S ++ A + A A K A P + + AP G
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 585
Query: 576 APGPKAAETASSSSASS 592
P+ A TA+S + SS
Sbjct: 586 TQAPRKAGTATSPAGSS 602
Score = 41.2 bits (95), Expect = 0.004
Identities = 82/354 (23%), Positives = 122/354 (34%), Gaps = 83/354 (23%)
Query: 385 DLLAPRSPMAKE----NMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLIS--- 437
+LL+ +SP N S T S P+ A+ M D+S S
Sbjct: 150 NLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDE 209
Query: 438 -----EWKQKSLEGRGLGLPDDASPGHLRAPAEP-----MAEEEE----EEEDEEEEEEE 483
+ +K L+ R P +PG PA P +A + + EE+ E EE
Sbjct: 210 TDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 269
Query: 484 EEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGV 543
+ E+E PA +L +QA+ + +Q GA +P
Sbjct: 270 SDSEEETPAAKAL---LQAKAS--------------------GKTSQVGAASAPAK---- 302
Query: 544 RAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDR 603
+ + GAA A P + +A ++A K E + SSS SDS + +
Sbjct: 303 ------ESPRKGAAPAPPGKTGPAVAKAQA-----GKREEDSQSSSEESDSEEEAPAQAK 351
Query: 604 DSASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPP 663
S AP + A AP + G A A + G A + G +
Sbjct: 352 PSGK-------AP-----QVRAASAPAKESPRKGAAPAPP---RKTGPAAAQVQVGKQEE 396
Query: 664 GVSPGSSVSDVDQEE---------PRFGAVATVNLATGEGLPPLGAADGALGPG 708
S SD D+E G V A+ G+ PLG G + PG
Sbjct: 397 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 450
Score = 40.8 bits (94), Expect = 0.005
Identities = 68/341 (19%), Positives = 118/341 (34%), Gaps = 44/341 (12%)
Query: 309 AVGNF-QAPPAEKPAAPAPAKDALRALTQRGH----DSVYQQNKSVSTDELGPPGRLEGA 363
++GN QA P PA P K A+ + +S + S S D P + A
Sbjct: 494 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA 553
Query: 364 PRPVA----------REKTSLGSLKRASVDVDLLAPR------SPMAKENMVTFSHTLPR 407
A ++ + S K A V V APR SP V P
Sbjct: 554 QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 613
Query: 408 ASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEP- 466
+ S ++ + + ++K + K L+ + +P S G AP P
Sbjct: 614 EDSSSSEESDSEEEKTGLAVTVGQAKSV-----GKGLQVKAASVPVKGSLGQGTAPVLPG 668
Query: 467 ------MAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTV-QARPGLGPRVILPPRAGPP 519
+ E++ED E EEE + E+ +P + +V + + P P A
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 728
Query: 520 PLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGP 579
I G A K + + K + ++ +A P + + + A
Sbjct: 729 ----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA------ 778
Query: 580 KAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPV 620
AA+ + S SS+ S S+ ++ ++ + H +
Sbjct: 779 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 819
Score = 38.5 bits (88), Expect = 0.023
Identities = 68/299 (22%), Positives = 109/299 (36%), Gaps = 24/299 (8%)
Query: 435 LISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEGPAPP 494
+ + W+Q S GR +DA+ + E E+EEE E E + A P
Sbjct: 49 IYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAK-----ATP 103
Query: 495 SLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGL-SPKSGAGVRAKWLMMAEK 553
L T + G + +A E+ +TG + P +G V +++ K
Sbjct: 104 RLASTNSSVLGADLPSSMKEKAKAE-----TEKAGKTGNSMPHPATGKTVAN---LLSGK 155
Query: 554 SGAAVANPPRLLQVIAMSKAPGAPGP--KAAETASSSSASSDSSQYRSPSDRDSASIVTI 611
S A P +++ ++ G+ AA+ S+ +DSS + S D +
Sbjct: 156 SPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEV- 214
Query: 612 DAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPGSSV 671
++ + A AP + G GA G + G +A + G KP S SS
Sbjct: 215 ---KASEKILQVRAASAPAK-GTPGKGATPAPPG--KAGAVASQTKAG-KPEEDSESSSE 267
Query: 672 SDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREAEA 730
D EE A A + +GAA R+ G G A +A+A
Sbjct: 268 ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQA 326
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 50.4 bits (119), Expect = 6e-06
Identities = 80/317 (25%), Positives = 119/317 (37%), Gaps = 42/317 (13%)
Query: 310 VGNFQAPPAEKP---AAPAPAKDALRALTQ-----RGHDSVYQQNKSVSTDELGPPGRLE 361
VG AP E P AAPAP A+ + R DS +S S +E +
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 362 G-APRPVAREKTSLGSLKRASVDVDLLAPRS--PMAKENMVTFSHTLPRASAPSLDDPAR 418
G AP+ A + S ++ + PR P A + V R+S+ D
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAP---PRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 487
Query: 419 RHMTIHV----PLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEE 474
++ PL S + S L G+G G PG + PA P A+ + E
Sbjct: 488 ALAAMNAAQVKPLGKSPQVKPASTMGMGPL-GKGAG---PVPPGKV-GPATPSAQVGKWE 542
Query: 475 EDEEEEEEEEEEEDEGPAPPSLYPT--------VQARPGLGPRVILPPRAGP-------- 518
ED E EE + +G P ++ P +QA+P P P +AGP
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
Query: 519 PPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAP---G 575
P+ + + + S ++ A + A A K A P + + AP G
Sbjct: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 662
Query: 576 APGPKAAETASSSSASS 592
P+ A TA+S + SS
Sbjct: 663 TQAPRKAGTATSPAGSS 679
Score = 41.2 bits (95), Expect = 0.004
Identities = 90/410 (21%), Positives = 139/410 (33%), Gaps = 77/410 (18%)
Query: 319 EKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRLEGAPRPVAREKTSL--GS 376
E+ + PA A + G ++ S S+DE G+ P V S
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 377 LKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLI 436
++A+ + +P K + + + S P +RS+
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPA-GTRSQVKA 293
Query: 437 SEWKQKSLEGRGLGLPDDASPGHLRAPAEP-----MAEEEE----EEEDEEEEEEEEEEE 487
SE K L+ R P +PG PA P +A + + EE+ E EE + E
Sbjct: 294 SE---KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 488 DEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKW 547
+E PA +L +QA+ + +Q GA +P
Sbjct: 351 EETPAAKAL---LQAKAS--------------------GKTSQVGAASAPAK-------- 379
Query: 548 LMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSAS 607
+ + GAA A P + +A ++A K E + SSS SDS + + S
Sbjct: 380 --ESPRKGAAPAPPGKTGPAVAKAQA-----GKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 608 IVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSP 667
AP + A AP + G A A + G A + G +
Sbjct: 433 -------AP-----QVRAASAPAKESPRKGAAPAPP---RKTGPAAAQVQVGKQEEDSRS 477
Query: 668 GSSVSDVDQEE---------PRFGAVATVNLATGEGLPPLGAADGALGPG 708
S SD D+E G V A+ G+ PLG G + PG
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 527
Score = 40.8 bits (94), Expect = 0.005
Identities = 68/341 (19%), Positives = 118/341 (34%), Gaps = 44/341 (12%)
Query: 309 AVGNF-QAPPAEKPAAPAPAKDALRALTQRGH----DSVYQQNKSVSTDELGPPGRLEGA 363
++GN QA P PA P K A+ + +S + S S D P + A
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA 630
Query: 364 PRPVA----------REKTSLGSLKRASVDVDLLAPR------SPMAKENMVTFSHTLPR 407
A ++ + S K A V V APR SP V P
Sbjct: 631 QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
Query: 408 ASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEP- 466
+ S ++ + + ++K + K L+ + +P S G AP P
Sbjct: 691 EDSSSSEESDSEEEKTGLAVTVGQAKSV-----GKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 467 ------MAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTV-QARPGLGPRVILPPRAGPP 519
+ E++ED E EEE + E+ +P + +V + + P P A
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 520 PLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGP 579
I G A K + + K + ++ +A P + + + A
Sbjct: 806 ----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA------ 855
Query: 580 KAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPV 620
AA+ + S SS+ S S+ ++ ++ + H +
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896
Score = 32.3 bits (72), Expect = 1.6
Identities = 76/362 (20%), Positives = 110/362 (30%), Gaps = 73/362 (20%)
Query: 435 LISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEE----------- 483
+ + W+Q S GR +DA+ + E E+EEE E E
Sbjct: 49 IYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLAST 108
Query: 484 ------------------EEEEDEG------PAPPSLYPTVQARPGLGPRVILPPRAGPP 519
E E G P P + G PR P A
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 520 PLVHIPEEGAQTGAGLSPKSG-------------------------------AGVRAKWL 548
+ EEG+ G + K G A V+A +
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 549 MMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSASI 608
E A P + + GA P A+ A S+SS+ S S+ ++ +
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 609 VTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPG 668
A ++ + A AP + G GA G + G +A + G KP S
Sbjct: 287 TRSQVKA-SEKILQVRAASAPAK-GTPGKGATPAPPG--KAGAVASQTKAG-KPEEDSES 341
Query: 669 SSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREA 728
SS D EE A A + +GAA R+ G G A +A
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 729 EA 730
+A
Sbjct: 402 QA 403
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 50.4 bits (119), Expect = 6e-06
Identities = 80/317 (25%), Positives = 119/317 (37%), Gaps = 42/317 (13%)
Query: 310 VGNFQAPPAEKP---AAPAPAKDALRALTQ-----RGHDSVYQQNKSVSTDELGPPGRLE 361
VG AP E P AAPAP A+ + R DS +S S +E +
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 362 G-APRPVAREKTSLGSLKRASVDVDLLAPRS--PMAKENMVTFSHTLPRASAPSLDDPAR 418
G AP+ A + S ++ + PR P A + V R+S+ D
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAP---PRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 487
Query: 419 RHMTIHV----PLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEE 474
++ PL S + S L G+G G PG + PA P A+ + E
Sbjct: 488 ALAAMNAAQVKPLGKSPQVKPASTMGMGPL-GKGAG---PVPPGKV-GPATPSAQVGKWE 542
Query: 475 EDEEEEEEEEEEEDEGPAPPSLYPT--------VQARPGLGPRVILPPRAGP-------- 518
ED E EE + +G P ++ P +QA+P P P +AGP
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
Query: 519 PPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAP---G 575
P+ + + + S ++ A + A A K A P + + AP G
Sbjct: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 662
Query: 576 APGPKAAETASSSSASS 592
P+ A TA+S + SS
Sbjct: 663 TQAPRKAGTATSPAGSS 679
Score = 41.2 bits (95), Expect = 0.004
Identities = 90/410 (21%), Positives = 139/410 (33%), Gaps = 77/410 (18%)
Query: 319 EKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRLEGAPRPVAREKTSL--GS 376
E+ + PA A + G ++ S S+DE G+ P V S
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 377 LKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLI 436
++A+ + +P K + + + S P +RS+
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPA-GTRSQVKA 293
Query: 437 SEWKQKSLEGRGLGLPDDASPGHLRAPAEP-----MAEEEE----EEEDEEEEEEEEEEE 487
SE K L+ R P +PG PA P +A + + EE+ E EE + E
Sbjct: 294 SE---KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 488 DEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKW 547
+E PA +L +QA+ + +Q GA +P
Sbjct: 351 EETPAAKAL---LQAKAS--------------------GKTSQVGAASAPAK-------- 379
Query: 548 LMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSAS 607
+ + GAA A P + +A ++A K E + SSS SDS + + S
Sbjct: 380 --ESPRKGAAPAPPGKTGPAVAKAQA-----GKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 608 IVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSP 667
AP + A AP + G A A + G A + G +
Sbjct: 433 -------AP-----QVRAASAPAKESPRKGAAPAPP---RKTGPAAAQVQVGKQEEDSRS 477
Query: 668 GSSVSDVDQEE---------PRFGAVATVNLATGEGLPPLGAADGALGPG 708
S SD D+E G V A+ G+ PLG G + PG
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 527
Score = 40.8 bits (94), Expect = 0.005
Identities = 68/341 (19%), Positives = 118/341 (34%), Gaps = 44/341 (12%)
Query: 309 AVGNF-QAPPAEKPAAPAPAKDALRALTQRGH----DSVYQQNKSVSTDELGPPGRLEGA 363
++GN QA P PA P K A+ + +S + S S D P + A
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA 630
Query: 364 PRPVA----------REKTSLGSLKRASVDVDLLAPR------SPMAKENMVTFSHTLPR 407
A ++ + S K A V V APR SP V P
Sbjct: 631 QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
Query: 408 ASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEP- 466
+ S ++ + + ++K + K L+ + +P S G AP P
Sbjct: 691 EDSSSSEESDSEEEKTGLAVTVGQAKSV-----GKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 467 ------MAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTV-QARPGLGPRVILPPRAGPP 519
+ E++ED E EEE + E+ +P + +V + + P P A
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 520 PLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGP 579
I G A K + + K + ++ +A P + + + A
Sbjct: 806 ----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA------ 855
Query: 580 KAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPV 620
AA+ + S SS+ S S+ ++ ++ + H +
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896
Score = 32.3 bits (72), Expect = 1.6
Identities = 76/362 (20%), Positives = 110/362 (30%), Gaps = 73/362 (20%)
Query: 435 LISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEE----------- 483
+ + W+Q S GR +DA+ + E E+EEE E E
Sbjct: 49 IYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLAST 108
Query: 484 ------------------EEEEDEG------PAPPSLYPTVQARPGLGPRVILPPRAGPP 519
E E G P P + G PR P A
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 520 PLVHIPEEGAQTGAGLSPKSG-------------------------------AGVRAKWL 548
+ EEG+ G + K G A V+A +
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 549 MMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSASI 608
E A P + + GA P A+ A S+SS+ S S+ ++ +
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 609 VTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPG 668
A ++ + A AP + G GA G + G +A + G KP S
Sbjct: 287 TRSQVKA-SEKILQVRAASAPAK-GTPGKGATPAPPG--KAGAVASQTKAG-KPEEDSES 341
Query: 669 SSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREA 728
SS D EE A A + +GAA R+ G G A +A
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 729 EA 730
+A
Sbjct: 402 QA 403
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 50.4 bits (119), Expect = 6e-06
Identities = 80/317 (25%), Positives = 119/317 (37%), Gaps = 42/317 (13%)
Query: 310 VGNFQAPPAEKP---AAPAPAKDALRALTQ-----RGHDSVYQQNKSVSTDELGPPGRLE 361
VG AP E P AAPAP A+ + R DS +S S +E +
Sbjct: 294 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 353
Query: 362 G-APRPVAREKTSLGSLKRASVDVDLLAPRS--PMAKENMVTFSHTLPRASAPSLDDPAR 418
G AP+ A + S ++ + PR P A + V R+S+ D
Sbjct: 354 GKAPQVRAASAPAKESPRKGAAPAP---PRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 410
Query: 419 RHMTIHV----PLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEE 474
++ PL S + S L G+G G PG + PA P A+ + E
Sbjct: 411 ALAAMNAAQVKPLGKSPQVKPASTMGMGPL-GKGAG---PVPPGKV-GPATPSAQVGKWE 465
Query: 475 EDEEEEEEEEEEEDEGPAPPSLYPT--------VQARPGLGPRVILPPRAGP-------- 518
ED E EE + +G P ++ P +QA+P P P +AGP
Sbjct: 466 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 525
Query: 519 PPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAP---G 575
P+ + + + S ++ A + A A K A P + + AP G
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 585
Query: 576 APGPKAAETASSSSASS 592
P+ A TA+S + SS
Sbjct: 586 TQAPRKAGTATSPAGSS 602
Score = 41.2 bits (95), Expect = 0.004
Identities = 82/354 (23%), Positives = 122/354 (34%), Gaps = 83/354 (23%)
Query: 385 DLLAPRSPMAKE----NMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLIS--- 437
+LL+ +SP N S T S P+ A+ M D+S S
Sbjct: 150 NLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDE 209
Query: 438 -----EWKQKSLEGRGLGLPDDASPGHLRAPAEP-----MAEEEE----EEEDEEEEEEE 483
+ +K L+ R P +PG PA P +A + + EE+ E EE
Sbjct: 210 TDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 269
Query: 484 EEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGV 543
+ E+E PA +L +QA+ + +Q GA +P
Sbjct: 270 SDSEEETPAAKAL---LQAKAS--------------------GKTSQVGAASAPAK---- 302
Query: 544 RAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDR 603
+ + GAA A P + +A ++A K E + SSS SDS + +
Sbjct: 303 ------ESPRKGAAPAPPGKTGPAVAKAQA-----GKREEDSQSSSEESDSEEEAPAQAK 351
Query: 604 DSASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPP 663
S AP + A AP + G A A + G A + G +
Sbjct: 352 PSGK-------AP-----QVRAASAPAKESPRKGAAPAPP---RKTGPAAAQVQVGKQEE 396
Query: 664 GVSPGSSVSDVDQEE---------PRFGAVATVNLATGEGLPPLGAADGALGPG 708
S SD D+E G V A+ G+ PLG G + PG
Sbjct: 397 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 450
Score = 40.8 bits (94), Expect = 0.005
Identities = 68/341 (19%), Positives = 118/341 (34%), Gaps = 44/341 (12%)
Query: 309 AVGNF-QAPPAEKPAAPAPAKDALRALTQRGH----DSVYQQNKSVSTDELGPPGRLEGA 363
++GN QA P PA P K A+ + +S + S S D P + A
Sbjct: 494 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA 553
Query: 364 PRPVA----------REKTSLGSLKRASVDVDLLAPR------SPMAKENMVTFSHTLPR 407
A ++ + S K A V V APR SP V P
Sbjct: 554 QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 613
Query: 408 ASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEP- 466
+ S ++ + + ++K + K L+ + +P S G AP P
Sbjct: 614 EDSSSSEESDSEEEKTGLAVTVGQAKSV-----GKGLQVKAASVPVKGSLGQGTAPVLPG 668
Query: 467 ------MAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTV-QARPGLGPRVILPPRAGPP 519
+ E++ED E EEE + E+ +P + +V + + P P A
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 728
Query: 520 PLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGP 579
I G A K + + K + ++ +A P + + + A
Sbjct: 729 ----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA------ 778
Query: 580 KAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPV 620
AA+ + S SS+ S S+ ++ ++ + H +
Sbjct: 779 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 819
Score = 38.5 bits (88), Expect = 0.023
Identities = 68/299 (22%), Positives = 109/299 (36%), Gaps = 24/299 (8%)
Query: 435 LISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEGPAPP 494
+ + W+Q S GR +DA+ + E E+EEE E E + A P
Sbjct: 49 IYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAK-----ATP 103
Query: 495 SLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGL-SPKSGAGVRAKWLMMAEK 553
L T + G + +A E+ +TG + P +G V +++ K
Sbjct: 104 RLASTNSSVLGADLPSSMKEKAKAE-----TEKAGKTGNSMPHPATGKTVAN---LLSGK 155
Query: 554 SGAAVANPPRLLQVIAMSKAPGAPGP--KAAETASSSSASSDSSQYRSPSDRDSASIVTI 611
S A P +++ ++ G+ AA+ S+ +DSS + S D +
Sbjct: 156 SPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEV- 214
Query: 612 DAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPGSSV 671
++ + A AP + G GA G + G +A + G KP S SS
Sbjct: 215 ---KASEKILQVRAASAPAK-GTPGKGATPAPPG--KAGAVASQTKAG-KPEEDSESSSE 267
Query: 672 SDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREAEA 730
D EE A A + +GAA R+ G G A +A+A
Sbjct: 268 ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQA 326
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 50.4 bits (119), Expect = 6e-06
Identities = 80/317 (25%), Positives = 119/317 (37%), Gaps = 42/317 (13%)
Query: 310 VGNFQAPPAEKP---AAPAPAKDALRALTQ-----RGHDSVYQQNKSVSTDELGPPGRLE 361
VG AP E P AAPAP A+ + R DS +S S +E +
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 362 G-APRPVAREKTSLGSLKRASVDVDLLAPRS--PMAKENMVTFSHTLPRASAPSLDDPAR 418
G AP+ A + S ++ + PR P A + V R+S+ D
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAP---PRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 487
Query: 419 RHMTIHV----PLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEE 474
++ PL S + S L G+G G PG + PA P A+ + E
Sbjct: 488 ALAAMNAAQVKPLGKSPQVKPASTMGMGPL-GKGAG---PVPPGKV-GPATPSAQVGKWE 542
Query: 475 EDEEEEEEEEEEEDEGPAPPSLYPT--------VQARPGLGPRVILPPRAGP-------- 518
ED E EE + +G P ++ P +QA+P P P +AGP
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
Query: 519 PPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAP---G 575
P+ + + + S ++ A + A A K A P + + AP G
Sbjct: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 662
Query: 576 APGPKAAETASSSSASS 592
P+ A TA+S + SS
Sbjct: 663 TQAPRKAGTATSPAGSS 679
Score = 41.2 bits (95), Expect = 0.004
Identities = 90/410 (21%), Positives = 139/410 (33%), Gaps = 77/410 (18%)
Query: 319 EKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRLEGAPRPVAREKTSL--GS 376
E+ + PA A + G ++ S S+DE G+ P V S
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 377 LKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLI 436
++A+ + +P K + + + S P +RS+
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPA-GTRSQVKA 293
Query: 437 SEWKQKSLEGRGLGLPDDASPGHLRAPAEP-----MAEEEE----EEEDEEEEEEEEEEE 487
SE K L+ R P +PG PA P +A + + EE+ E EE + E
Sbjct: 294 SE---KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 488 DEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKW 547
+E PA +L +QA+ + +Q GA +P
Sbjct: 351 EETPAAKAL---LQAKAS--------------------GKTSQVGAASAPAK-------- 379
Query: 548 LMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSAS 607
+ + GAA A P + +A ++A K E + SSS SDS + + S
Sbjct: 380 --ESPRKGAAPAPPGKTGPAVAKAQA-----GKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 608 IVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSP 667
AP + A AP + G A A + G A + G +
Sbjct: 433 -------AP-----QVRAASAPAKESPRKGAAPAPP---RKTGPAAAQVQVGKQEEDSRS 477
Query: 668 GSSVSDVDQEE---------PRFGAVATVNLATGEGLPPLGAADGALGPG 708
S SD D+E G V A+ G+ PLG G + PG
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 527
Score = 40.8 bits (94), Expect = 0.005
Identities = 68/341 (19%), Positives = 118/341 (34%), Gaps = 44/341 (12%)
Query: 309 AVGNF-QAPPAEKPAAPAPAKDALRALTQRGH----DSVYQQNKSVSTDELGPPGRLEGA 363
++GN QA P PA P K A+ + +S + S S D P + A
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA 630
Query: 364 PRPVA----------REKTSLGSLKRASVDVDLLAPR------SPMAKENMVTFSHTLPR 407
A ++ + S K A V V APR SP V P
Sbjct: 631 QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
Query: 408 ASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEP- 466
+ S ++ + + ++K + K L+ + +P S G AP P
Sbjct: 691 EDSSSSEESDSEEEKTGLAVTVGQAKSV-----GKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 467 ------MAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTV-QARPGLGPRVILPPRAGPP 519
+ E++ED E EEE + E+ +P + +V + + P P A
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 520 PLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGP 579
I G A K + + K + ++ +A P + + + A
Sbjct: 806 ----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA------ 855
Query: 580 KAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPV 620
AA+ + S SS+ S S+ ++ ++ + H +
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896
Score = 32.3 bits (72), Expect = 1.6
Identities = 76/362 (20%), Positives = 110/362 (30%), Gaps = 73/362 (20%)
Query: 435 LISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEE----------- 483
+ + W+Q S GR +DA+ + E E+EEE E E
Sbjct: 49 IYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLAST 108
Query: 484 ------------------EEEEDEG------PAPPSLYPTVQARPGLGPRVILPPRAGPP 519
E E G P P + G PR P A
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 520 PLVHIPEEGAQTGAGLSPKSG-------------------------------AGVRAKWL 548
+ EEG+ G + K G A V+A +
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 549 MMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSASI 608
E A P + + GA P A+ A S+SS+ S S+ ++ +
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 609 VTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPG 668
A ++ + A AP + G GA G + G +A + G KP S
Sbjct: 287 TRSQVKA-SEKILQVRAASAPAK-GTPGKGATPAPPG--KAGAVASQTKAG-KPEEDSES 341
Query: 669 SSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREA 728
SS D EE A A + +GAA R+ G G A +A
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 729 EA 730
+A
Sbjct: 402 QA 403
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 50.4 bits (119), Expect = 6e-06
Identities = 80/317 (25%), Positives = 119/317 (37%), Gaps = 42/317 (13%)
Query: 310 VGNFQAPPAEKP---AAPAPAKDALRALTQ-----RGHDSVYQQNKSVSTDELGPPGRLE 361
VG AP E P AAPAP A+ + R DS +S S +E +
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 362 G-APRPVAREKTSLGSLKRASVDVDLLAPRS--PMAKENMVTFSHTLPRASAPSLDDPAR 418
G AP+ A + S ++ + PR P A + V R+S+ D
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAP---PRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 487
Query: 419 RHMTIHV----PLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEE 474
++ PL S + S L G+G G PG + PA P A+ + E
Sbjct: 488 ALAAMNAAQVKPLGKSPQVKPASTMGMGPL-GKGAG---PVPPGKV-GPATPSAQVGKWE 542
Query: 475 EDEEEEEEEEEEEDEGPAPPSLYPT--------VQARPGLGPRVILPPRAGP-------- 518
ED E EE + +G P ++ P +QA+P P P +AGP
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
Query: 519 PPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAP---G 575
P+ + + + S ++ A + A A K A P + + AP G
Sbjct: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 662
Query: 576 APGPKAAETASSSSASS 592
P+ A TA+S + SS
Sbjct: 663 TQAPRKAGTATSPAGSS 679
Score = 41.2 bits (95), Expect = 0.004
Identities = 90/410 (21%), Positives = 139/410 (33%), Gaps = 77/410 (18%)
Query: 319 EKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRLEGAPRPVAREKTSL--GS 376
E+ + PA A + G ++ S S+DE G+ P V S
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 377 LKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLI 436
++A+ + +P K + + + S P +RS+
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPA-GTRSQVKA 293
Query: 437 SEWKQKSLEGRGLGLPDDASPGHLRAPAEP-----MAEEEE----EEEDEEEEEEEEEEE 487
SE K L+ R P +PG PA P +A + + EE+ E EE + E
Sbjct: 294 SE---KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 488 DEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKW 547
+E PA +L +QA+ + +Q GA +P
Sbjct: 351 EETPAAKAL---LQAKAS--------------------GKTSQVGAASAPAK-------- 379
Query: 548 LMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSAS 607
+ + GAA A P + +A ++A K E + SSS SDS + + S
Sbjct: 380 --ESPRKGAAPAPPGKTGPAVAKAQA-----GKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 608 IVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSP 667
AP + A AP + G A A + G A + G +
Sbjct: 433 -------AP-----QVRAASAPAKESPRKGAAPAPP---RKTGPAAAQVQVGKQEEDSRS 477
Query: 668 GSSVSDVDQEE---------PRFGAVATVNLATGEGLPPLGAADGALGPG 708
S SD D+E G V A+ G+ PLG G + PG
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 527
Score = 40.8 bits (94), Expect = 0.005
Identities = 68/341 (19%), Positives = 118/341 (34%), Gaps = 44/341 (12%)
Query: 309 AVGNF-QAPPAEKPAAPAPAKDALRALTQRGH----DSVYQQNKSVSTDELGPPGRLEGA 363
++GN QA P PA P K A+ + +S + S S D P + A
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA 630
Query: 364 PRPVA----------REKTSLGSLKRASVDVDLLAPR------SPMAKENMVTFSHTLPR 407
A ++ + S K A V V APR SP V P
Sbjct: 631 QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
Query: 408 ASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEP- 466
+ S ++ + + ++K + K L+ + +P S G AP P
Sbjct: 691 EDSSSSEESDSEEEKTGLAVTVGQAKSV-----GKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 467 ------MAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTV-QARPGLGPRVILPPRAGPP 519
+ E++ED E EEE + E+ +P + +V + + P P A
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 520 PLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGP 579
I G A K + + K + ++ +A P + + + A
Sbjct: 806 ----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA------ 855
Query: 580 KAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPV 620
AA+ + S SS+ S S+ ++ ++ + H +
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896
Score = 32.3 bits (72), Expect = 1.6
Identities = 76/362 (20%), Positives = 110/362 (30%), Gaps = 73/362 (20%)
Query: 435 LISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEE----------- 483
+ + W+Q S GR +DA+ + E E+EEE E E
Sbjct: 49 IYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLAST 108
Query: 484 ------------------EEEEDEG------PAPPSLYPTVQARPGLGPRVILPPRAGPP 519
E E G P P + G PR P A
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 520 PLVHIPEEGAQTGAGLSPKSG-------------------------------AGVRAKWL 548
+ EEG+ G + K G A V+A +
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 549 MMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSASI 608
E A P + + GA P A+ A S+SS+ S S+ ++ +
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPP--AKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 609 VTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPG 668
A ++ + A AP + G GA G + G +A + G KP S
Sbjct: 287 TRSQVKA-SEKILQVRAASAPAK-GTPGKGATPAPPG--KAGAVASQTKAG-KPEEDSES 341
Query: 669 SSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREA 728
SS D EE A A + +GAA R+ G G A +A
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 729 EA 730
+A
Sbjct: 402 QA 403
>gi|38372931 brevican isoform 2 [Homo sapiens]
Length = 671
Score = 50.4 bits (119), Expect = 6e-06
Identities = 59/228 (25%), Positives = 80/228 (35%), Gaps = 68/228 (29%)
Query: 469 EEEEEEEDEEEEEEEEEEED-------------EGPAPPSLYPTVQA------------- 502
EEEE+ EDEEE+EEEEEEE+ P P + PT A
Sbjct: 454 EEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARA 513
Query: 503 --RPGLGP------RVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKS 554
+PG P PPR PP +P + A SP + L+ A +
Sbjct: 514 VLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPST--------LVEAREV 565
Query: 555 GAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASS---------DSSQYRSPSDRDS 605
G A P + G P ++ ET SS A S + + +PS+ +S
Sbjct: 566 GEATGGP----------ELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNS 615
Query: 606 ASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLA 653
PV+ P + + GG A A G G A
Sbjct: 616 GRTAPAGTSVQAQPVL-------PTDSASRGGVAVVPASGNSAQGSTA 656
>gi|4504425 high-mobility group box 1 [Homo sapiens]
Length = 215
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/60 (43%), Positives = 40/60 (66%), Gaps = 1/60 (1%)
Query: 431 RSKQLISEWKQKSLEGRGLGLPDDASPGHLRAP-AEPMAEEEEEEEDEEEEEEEEEEEDE 489
++ +L ++++ R G PD A G ++A ++ EEEE+EEDEE+EEEEE+EEDE
Sbjct: 147 KAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDE 206
>gi|118600967 shroom family member 4 [Homo sapiens]
Length = 1493
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/74 (41%), Positives = 39/74 (52%), Gaps = 4/74 (5%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPT-VQARPGLGPRVILPPRAGPPPLVH 523
E EEEEEEE+EEEEEEEE EE+E PP + + L P +L P PL
Sbjct: 1132 EEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQ---PQPLSF 1188
Query: 524 IPEEGAQTGAGLSP 537
EG++ G+ P
Sbjct: 1189 GHLEGSRQGSQSVP 1202
Score = 35.8 bits (81), Expect = 0.15
Identities = 14/29 (48%), Positives = 23/29 (79%)
Query: 461 RAPAEPMAEEEEEEEDEEEEEEEEEEEDE 489
RA + +++++++ EEEEEEEEEEE+E
Sbjct: 1116 RAAQQQKQQQQQQKQQEEEEEEEEEEEEE 1144
Score = 35.4 bits (80), Expect = 0.19
Identities = 13/21 (61%), Positives = 21/21 (100%)
Query: 469 EEEEEEEDEEEEEEEEEEEDE 489
++++++E+EEEEEEEEEEE+E
Sbjct: 1126 QQQKQQEEEEEEEEEEEEEEE 1146
Score = 35.0 bits (79), Expect = 0.25
Identities = 13/28 (46%), Positives = 23/28 (82%)
Query: 462 APAEPMAEEEEEEEDEEEEEEEEEEEDE 489
A + ++++++++EEEEEEEEEEE+E
Sbjct: 1118 AQQQKQQQQQQKQQEEEEEEEEEEEEEE 1145
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/37 (62%), Positives = 28/37 (75%)
Query: 453 DDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDE 489
D S + A E ++EEEEEEE+EEEEEEEEEEE+E
Sbjct: 284 DSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEE 320
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/25 (84%), Positives = 22/25 (88%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEEEEEEEEEDE
Sbjct: 301 EEEEEEEEEEEEEEEEEEEEEEEDE 325
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/37 (56%), Positives = 25/37 (67%)
Query: 454 DASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEG 490
+A L E EEEEEEE+EEEEEEEEE+E+ G
Sbjct: 292 EALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESG 328
Score = 40.0 bits (92), Expect = 0.008
Identities = 18/37 (48%), Positives = 25/37 (67%)
Query: 453 DDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDE 489
D+ ++ E + E+ EEE+EEEEEEEEEEE+E
Sbjct: 280 DERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEE 316
Score = 35.8 bits (81), Expect = 0.15
Identities = 16/25 (64%), Positives = 20/25 (80%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEEEE+EE ++
Sbjct: 306 EEEEEEEEEEEEEEEEEEDEESGNQ 330
Score = 32.3 bits (72), Expect = 1.6
Identities = 14/25 (56%), Positives = 18/25 (72%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEE+EE + +
Sbjct: 308 EEEEEEEEEEEEEEEEDEESGNQSD 332
Score = 30.0 bits (66), Expect = 8.2
Identities = 13/26 (50%), Positives = 17/26 (65%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDEG 490
E EEEEEEE+EE+EE + + G
Sbjct: 310 EEEEEEEEEEEEEEDEESGNQSDRSG 335
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/37 (62%), Positives = 28/37 (75%)
Query: 453 DDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDE 489
D S + A E ++EEEEEEE+EEEEEEEEEEE+E
Sbjct: 284 DSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEE 320
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/25 (84%), Positives = 22/25 (88%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEEEEEEEEEDE
Sbjct: 301 EEEEEEEEEEEEEEEEEEEEEEEDE 325
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/37 (56%), Positives = 25/37 (67%)
Query: 454 DASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEG 490
+A L E EEEEEEE+EEEEEEEEE+E+ G
Sbjct: 292 EALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESG 328
Score = 40.0 bits (92), Expect = 0.008
Identities = 18/37 (48%), Positives = 25/37 (67%)
Query: 453 DDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDE 489
D+ ++ E + E+ EEE+EEEEEEEEEEE+E
Sbjct: 280 DERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEE 316
Score = 35.8 bits (81), Expect = 0.15
Identities = 16/25 (64%), Positives = 20/25 (80%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEEEE+EE ++
Sbjct: 306 EEEEEEEEEEEEEEEEEEDEESGNQ 330
Score = 32.3 bits (72), Expect = 1.6
Identities = 14/25 (56%), Positives = 18/25 (72%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDE 489
E EEEEEEE+EEEE+EE + +
Sbjct: 308 EEEEEEEEEEEEEEEEDEESGNQSD 332
Score = 30.0 bits (66), Expect = 8.2
Identities = 13/26 (50%), Positives = 17/26 (65%)
Query: 465 EPMAEEEEEEEDEEEEEEEEEEEDEG 490
E EEEEEEE+EE+EE + + G
Sbjct: 310 EEEEEEEEEEEEEEDEESGNQSDRSG 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,167,666
Number of Sequences: 37866
Number of extensions: 1972535
Number of successful extensions: 46408
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 560
Number of HSP's that attempted gapping in prelim test: 23704
Number of HSP's gapped (non-prelim): 11437
length of query: 746
length of database: 18,247,518
effective HSP length: 110
effective length of query: 636
effective length of database: 14,082,258
effective search space: 8956316088
effective search space used: 8956316088
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.