Search of human proteins with 50582989

Search of human proteins with 50582989

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
         (963 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]      1916   0.0  
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]     1840   0.0  
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]      1022   0.0  
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]      1002   0.0  
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 605   e-173
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     167   3e-41
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       167   3e-41
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     161   2e-39
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       161   2e-39
gi|4758968 cytohesin 3 [Homo sapiens]                                 161   3e-39
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   159   9e-39
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   152   1e-36
gi|7019505 cytohesin 4 [Homo sapiens]                                 146   8e-35
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   137   6e-32
gi|48928044 F-box only protein 8 [Homo sapiens]                       106   9e-23
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]     93   1e-18
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]     90   1e-17
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...    89   2e-17
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...    89   2e-17
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]       89   3e-17
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    51   6e-06
gi|40788007 FYN binding protein (FYB-120/130) isoform 2 [Homo sa...    42   0.003
gi|42476118 FYN binding protein (FYB-120/130) isoform 1 [Homo sa...    42   0.003
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [...    40   0.010
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...    40   0.010
gi|55749769 CWC22 spliceosome-associated protein homolog [Homo s...    40   0.014
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        40   0.014
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...    39   0.018
gi|51599156 chromodomain helicase DNA binding protein 4 [Homo sa...    39   0.031
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...    38   0.040

>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score = 1916 bits (4964), Expect = 0.0
 Identities = 963/963 (100%), Positives = 963/963 (100%)

Query: 1   MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEH 60
           MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEH
Sbjct: 1   MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEH 60

Query: 61  TSVGAYGLYSGPPGQQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQ 120
           TSVGAYGLYSGPPGQQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQ
Sbjct: 61  TSVGAYGLYSGPPGQQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQ 120

Query: 121 VEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFS 180
           VEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFS
Sbjct: 121 VEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFS 180

Query: 181 FEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELE 240
           FEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELE
Sbjct: 181 FEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELE 240

Query: 241 DAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASY 300
           DAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASY
Sbjct: 241 DAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASY 300

Query: 301 SDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCR 360
           SDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCR
Sbjct: 301 SDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCR 360

Query: 361 STPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKH 420
           STPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKH
Sbjct: 361 STPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKH 420

Query: 421 GPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSN 480
           GPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSN
Sbjct: 421 GPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSN 480

Query: 481 DTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPE 540
           DTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPE
Sbjct: 481 DTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPE 540

Query: 541 KGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFS 600
           KGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFS
Sbjct: 541 KGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFS 600

Query: 601 TMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAII 660
           TMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAII
Sbjct: 601 TMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAII 660

Query: 661 LLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVS 720
           LLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVS
Sbjct: 661 LLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVS 720

Query: 721 QVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFL 780
           QVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFL
Sbjct: 721 QVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFL 780

Query: 781 FNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLI 840
           FNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLI
Sbjct: 781 FNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLI 840

Query: 841 NFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNG 900
           NFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNG
Sbjct: 841 NFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNG 900

Query: 901 TLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSV 960
           TLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSV
Sbjct: 901 TLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSV 960

Query: 961 LCS 963
           LCS
Sbjct: 961 LCS 963


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score = 1840 bits (4765), Expect = 0.0
 Identities = 927/927 (100%), Positives = 927/927 (100%)

Query: 23  VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 82
           VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP
Sbjct: 9   VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 68

Query: 83  KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 142
           KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ
Sbjct: 69  KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 128

Query: 143 TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTND 202
           TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTND
Sbjct: 129 TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTND 188

Query: 203 GSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRS 262
           GSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRS
Sbjct: 189 GSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRS 248

Query: 263 LHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAG 322
           LHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAG
Sbjct: 249 LHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAG 308

Query: 323 DRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTI 382
           DRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTI
Sbjct: 309 DRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTI 368

Query: 383 EPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPP 442
           EPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPP
Sbjct: 369 EPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPP 428

Query: 443 RPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSK 502
           RPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSK
Sbjct: 429 RPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSK 488

Query: 503 QTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHF 562
           QTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHF
Sbjct: 489 QTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHF 548

Query: 563 LLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQ 622
           LLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQ
Sbjct: 549 LLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQ 608

Query: 623 KVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDF 682
           KVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDF
Sbjct: 609 KVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDF 668

Query: 683 IKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGL 742
           IKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGL
Sbjct: 669 IKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGL 728

Query: 743 GCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSF 802
           GCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSF
Sbjct: 729 GCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSF 788

Query: 803 RQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIA 862
           RQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIA
Sbjct: 789 RQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIA 848

Query: 863 EVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSAL 922
           EVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSAL
Sbjct: 849 EVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSAL 908

Query: 923 SSSLRDLSEAGKRGRRSSAGSLESNVE 949
           SSSLRDLSEAGKRGRRSSAGSLESNVE
Sbjct: 909 SSSLRDLSEAGKRGRRSSAGSLESNVE 935


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 1022 bits (2643), Expect = 0.0
 Identities = 586/966 (60%), Positives = 706/966 (73%), Gaps = 84/966 (8%)

Query: 23   VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 82
            VEG+AP S+  T++DSP + P   L    S  P    H      G+  G P  Q    R 
Sbjct: 247  VEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ----RA 296

Query: 83   KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 142
            +LQ ++  LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG  ++R AARTIQ
Sbjct: 297  RLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQ 355

Query: 143  TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQVSVTN 201
            TAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE  EK  + +YFEGK  S+ +
Sbjct: 356  TAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASL-D 414

Query: 202  DGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAE 252
            +G+  GA              CG   +     S   S +F++ ITELED+FS+QVKSLAE
Sbjct: 415  EGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVKSLAE 473

Query: 253  SIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEE 311
            SID+ALNC  S    E P       R+++ Q           D    S+SD+ LY+D+  
Sbjct: 474  SIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYLDDT- 523

Query: 312  LSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADTDTSC 359
                +P  Q+ +R  STE   + R     P++WA A             +ED +  + + 
Sbjct: 524  ----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSREEGTR 573

Query: 360  RSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPK 419
            R    LE ++ RLR  HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ  YE       G+ K
Sbjct: 574  RGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK 633

Query: 420  H-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES--DYSD 467
            H GP   AP   +  P  E    P PP PL    +S    +G A   R  K E+  + SD
Sbjct: 634  HKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD 692

Query: 468  G-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFSNDVI 523
            G DN+S+ S+SNSN+TINCSS SSSRDSLRE     L KQTY +E R+SWDSPAF+NDV+
Sbjct: 693  GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV 752

Query: 524  RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
            ++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLGNRQK
Sbjct: 753  QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812

Query: 584  QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
            QFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CNP +V
Sbjct: 813  QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872

Query: 644  RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
            RQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++L+GI
Sbjct: 873  RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932

Query: 704  YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 763
            Y+RI+ REL+TN+DHVSQVQ VE++IVGKKP          VLSLPHRRLVC C+L+EVP
Sbjct: 933  YQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQLYEVP 982

Query: 764  DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 823
            DPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK  VTYSFRQSF L  M + LF+N YY  
Sbjct: 983  DPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQF 1042

Query: 824  GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 883
            GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQKG++
Sbjct: 1043 GIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMM 1102

Query: 884  RPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGS 943
            RP+ SQ     K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AGKRGRR+S GS
Sbjct: 1103 RPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGS 1161

Query: 944  LESNVE 949
            L+S +E
Sbjct: 1162 LDSTIE 1167


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score = 1002 bits (2590), Expect = 0.0
 Identities = 576/953 (60%), Positives = 694/953 (72%), Gaps = 84/953 (8%)

Query: 20  DSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRT 79
           +S VEG+AP S+  T++DSP + P   L    S  P    H      G+  G P  Q   
Sbjct: 39  ESSVEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ--- 89

Query: 80  RRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAAR 139
            R +LQ ++  LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG  ++R AAR
Sbjct: 90  -RARLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAAR 147

Query: 140 TIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQVS 198
           TIQTAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE  EK  + +YFEGK  S
Sbjct: 148 TIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPAS 207

Query: 199 VTNDGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKS 249
           + ++G+  GA              CG   +     S   S +F++ ITELED+FS+QVKS
Sbjct: 208 L-DEGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVKS 265

Query: 250 LAESIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYID 308
           LAESID+ALNC  S    E P       R+++ Q           D    S+SD+ LY+D
Sbjct: 266 LAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYLD 316

Query: 309 EEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADTD 356
           +      +P  Q+ +R  STE   + R     P++WA A             +ED +  +
Sbjct: 317 DT-----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSREE 365

Query: 357 TSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQG 416
            + R    LE ++ RLR  HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ  YE       G
Sbjct: 366 GTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHG 425

Query: 417 SPKH-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES--D 464
           + KH GP   AP   +  P  E    P PP PL    +S    +G A   R  K E+  +
Sbjct: 426 TLKHKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGE 484

Query: 465 YSDG-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFSN 520
            SDG DN+S+ S+SNSN+TINCSS SSSRDSLRE     L KQTY +E R+SWDSPAF+N
Sbjct: 485 NSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNN 544

Query: 521 DVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGN 580
           DV+++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLGN
Sbjct: 545 DVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGN 604

Query: 581 RQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNP 640
           RQKQFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CNP
Sbjct: 605 RQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNP 664

Query: 641 GVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREML 700
            +VRQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++L
Sbjct: 665 ALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLL 724

Query: 701 MGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLF 760
           +GIY+RI+ REL+TN+DHVSQVQ VE++IVGKKP          VLSLPHRRLVC C+L+
Sbjct: 725 VGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQLY 774

Query: 761 EVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQY 820
           EVPDPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK  VTYSFRQSF L  M + LF+N Y
Sbjct: 775 EVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSY 834

Query: 821 YPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK 880
           Y  GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQK
Sbjct: 835 YQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQK 894

Query: 881 GVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAG 933
           G++RP+ SQ     K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AG
Sbjct: 895 GMMRPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAG 946


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  605 bits (1559), Expect = e-173
 Identities = 368/789 (46%), Positives = 470/789 (59%), Gaps = 102/789 (12%)

Query: 123 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 182
           MLE KYGG LV+R AA TIQTAFRQYQ++KNFE++R+S+ E+R+ RRI L  +R      
Sbjct: 1   MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVR------ 54

Query: 183 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 242
                          S T +       +    G +  P  ++SP+    FA  +TELED+
Sbjct: 55  ---------------SPTAESLAAEKALMEGYGLVGLPL-VRSPSLPPTFAGTLTELEDS 98

Query: 243 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 302
           F+ QV+SLA+SID                DA      +   +L      +L +       
Sbjct: 99  FTEQVQSLAKSID----------------DALSTWSLKTMCSLRESGAYQLHQAL----- 137

Query: 303 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 362
                            QA   P   E++      G AP+       +D A+T       
Sbjct: 138 -----------------QAAAGPPGLEAE------GRAPESAGPGPGDDAAET------- 167

Query: 363 PSLERQEQRLRVEHLPLLTIEPPSD-----SSVDLSDRSERGSLKRQSAYERSLGGQQGS 417
           P L        +     +T++  +      SS  LS  +  G+   Q+  E + G  +  
Sbjct: 168 PGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQG 227

Query: 418 PKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSD---------- 467
              G  +    ++ RE+            S  A   +A +  + E +             
Sbjct: 228 ETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAE 287

Query: 468 -GDNDSINSTSNSNDTINCSSESS---SRDSLREQTLSKQTYHKEARNSWDSPAFSNDVI 523
            GD + ++S+S S  +    SE+S   S+D+L+   LS   YH E   S  SP  S D +
Sbjct: 288 AGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTL 347

Query: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
           RKR YRIGLNLFN  P+KG+Q+LI RGF+PDTP+GVAHFLLQRKGLSRQMIGEFLGN +K
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407

Query: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
           QFNRDVLDCVVDEMDFS+MELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYC+CNP VV
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467

Query: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
           +QF NPDTIFILAFAIILLNTDMYSPN+KP+RKM LEDFI+NLRGVDDG DIPRE+++GI
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527

Query: 704 YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 763
           YERI+++ELK+NEDHV+ V KVEK IVG K           VLS+PHRRLVC  RLFEV 
Sbjct: 528 YERIQQKELKSNEDHVTYVTKVEKSIVGMK----------TVLSVPHRRLVCCSRLFEVT 577

Query: 764 DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 823
           D NK QK   HQRE+FLFNDLLV+ K+  KKK+S TY+F +S  L GMQ  LFEN+YY +
Sbjct: 578 DVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSH 637

Query: 824 GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 883
           GI L + + G++ K +++F A    + +KF +DL+ESIAEV E+E+ RIE ELEKQ+G  
Sbjct: 638 GITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTK 697

Query: 884 RPSMSQCSS 892
             S   C +
Sbjct: 698 TLSFKPCGA 706


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  167 bits (424), Expect = 3e-41
 Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)

Query: 519 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 578
           S  + R R   +G   FN  P+KG+Q+L+E   + +TP  +A FL + +GL++  IG++L
Sbjct: 56  SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115

Query: 579 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 638
           G R+ + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+C
Sbjct: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174

Query: 639 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 698
           NPGV   F++ DT ++L+FA+I+LNT +++PNV+   K  LE F+   RG+++G D+P E
Sbjct: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229

Query: 699 MLMGIYERIRKRELKTNED 717
           +L  +Y+ IR    K  ED
Sbjct: 230 LLRNLYDSIRNEPFKIPED 248


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  167 bits (424), Expect = 3e-41
 Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)

Query: 519 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 578
           S  + R R   +G   FN  P+KG+Q+L+E   + +TP  +A FL + +GL++  IG++L
Sbjct: 56  SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115

Query: 579 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 638
           G R+ + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+C
Sbjct: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174

Query: 639 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 698
           NPGV   F++ DT ++L+FA+I+LNT +++PNV+   K  LE F+   RG+++G D+P E
Sbjct: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229

Query: 699 MLMGIYERIRKRELKTNED 717
           +L  +Y+ IR    K  ED
Sbjct: 230 LLRNLYDSIRNEPFKIPED 248


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  161 bits (408), Expect = 2e-39
 Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
           R +   +G   FN  P+KG+Q+LIE   + +T   +A FL + +GL++  IG++LG R  
Sbjct: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120

Query: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN GV 
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179

Query: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
             F++ DT ++L+FAII+LNT +++PNVK   K  +E FI   RG++DG D+P E+L  +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235

Query: 704 YERIRKRELKTNED 717
           YE I+    K  ED
Sbjct: 236 YESIKNEPFKIPED 249


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  161 bits (408), Expect = 2e-39
 Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
           R +   +G   FN  P+KG+Q+LIE   + +T   +A FL + +GL++  IG++LG R  
Sbjct: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120

Query: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN GV 
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179

Query: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
             F++ DT ++L+FAII+LNT +++PNVK   K  +E FI   RG++DG D+P E+L  +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235

Query: 704 YERIRKRELKTNED 717
           YE I+    K  ED
Sbjct: 236 YESIKNEPFKIPED 249


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  161 bits (407), Expect = 3e-39
 Identities = 82/194 (42%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
           R +   +G   FN  P+KG+Q+LIE   +  +P  VA FL + +GL++ +IG++LG R  
Sbjct: 66  RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124

Query: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNPGV 
Sbjct: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183

Query: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
             F++ DT ++L+FAII+LNT +++ NV+   K   E FI   RG+++G D+P E+L  +
Sbjct: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVRD--KPTAERFIAMNRGINEGGDLPEELLRNL 239

Query: 704 YERIRKRELKTNED 717
           YE I+    K  ED
Sbjct: 240 YESIKNEPFKIPED 253


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  159 bits (403), Expect = 9e-39
 Identities = 83/186 (44%), Positives = 120/186 (64%), Gaps = 4/186 (2%)

Query: 531 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 590
           G++LFNKKP++G+QYL E+G +  TP  +A FL Q + L    +GEFLG+  K FN++V+
Sbjct: 705 GIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVM 763

Query: 591 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 650
              VD+ DFS  +   ALR F    R+ GEAQK++RL+E F+ RY  CN G    F + D
Sbjct: 764 YAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASAD 822

Query: 651 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 710
           T ++LA++II+L TD++SP VK   KM  E +IK  RG++D +D+P E L  IY  I  +
Sbjct: 823 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGK 880

Query: 711 ELKTNE 716
           ++   E
Sbjct: 881 KISMKE 886


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  152 bits (385), Expect = 1e-36
 Identities = 79/186 (42%), Positives = 119/186 (63%), Gaps = 4/186 (2%)

Query: 531 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 590
           G+ LFNKKP++G+Q+L E+G +  +   +A FL Q + L    +G+FLG+  + FN++V+
Sbjct: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708

Query: 591 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 650
              VD++DF   E   ALR F    R+ GEAQK++RL+E F+ RY  CN G    F + D
Sbjct: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767

Query: 651 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 710
           T ++LA++II+L TD++SP VK   KM  E +IK  RG++D +D+P E L  IYE I  +
Sbjct: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825

Query: 711 ELKTNE 716
           ++   E
Sbjct: 826 KIAMKE 831


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  146 bits (369), Expect = 8e-35
 Identities = 74/194 (38%), Positives = 119/194 (61%), Gaps = 6/194 (3%)

Query: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
           +++   IG   FN  P KG+QY IE   +      +A FL + +GL++  IG +LG R  
Sbjct: 61  KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120

Query: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
             N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNPGV 
Sbjct: 121 -INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV- 178

Query: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
             F++ DT ++L+F+II+LNT +++PNV+   +   E F+   RG+++G D+P + L  +
Sbjct: 179 --FQSTDTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNL 234

Query: 704 YERIRKRELKTNED 717
           ++ I+       ED
Sbjct: 235 FDSIKSEPFSIPED 248


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  137 bits (344), Expect = 6e-32
 Identities = 78/204 (38%), Positives = 122/204 (59%), Gaps = 9/204 (4%)

Query: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGF--VPDTPVGVAHFLLQRKGLSRQMIGEFLGNR 581
           +K+    G   FN+KP+KG+Q+L E+G   +P     VA +L +   L ++MIGEF+ +R
Sbjct: 699 KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDR 758

Query: 582 QKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPG 641
           +   N D+L+  V    F  + LDEALR +    R+ GEA  ++RL+EAF++R+  CN  
Sbjct: 759 K---NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGS 815

Query: 642 VVRQFRNPDTIFILAFAIILLNTDMYSPNV-KPERKMKLEDFIKNLRGVDDGEDIPREML 700
               F N D  F LA+A+I+LNTD ++ NV K    M LE+F KNL+GV+ G+D  +++L
Sbjct: 816 ---PFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDIL 872

Query: 701 MGIYERIRKRELKTNEDHVSQVQK 724
             +Y  I+  E+   E+    V++
Sbjct: 873 EDMYHAIKNEEIVMPEEQTGLVRE 896


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score =  106 bits (265), Expect = 9e-23
 Identities = 74/229 (32%), Positives = 121/229 (52%), Gaps = 17/229 (7%)

Query: 484 NCSSESSSRDSLREQTLSKQTY-HKEARNSWDSPAFSNDVIRKRHYRI--GLNLFNKKPE 540
           +C  +  + D L  Q L K T+ H    N      FS    RK + ++  G   FN  P+
Sbjct: 95  SCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFS---FRKLYMQLDEGSLTFNANPD 151

Query: 541 KGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFS 600
           +GV Y + +G + D+P  +A F+   + L+ + +  +L  R     RDVLD +V   +F 
Sbjct: 152 EGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDER-----RDVLDDLVTLHNFR 206

Query: 601 TMELDEALRKFQAHIRVQGE-AQKVERLIEAFSQRYCICNPGVVRQF-RNPDTIFILAFA 658
              L  ALR+F  HI    E  + +E LI  FS R+C CNP ++R+   +PD +++L ++
Sbjct: 207 NQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYS 266

Query: 659 IILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERI 707
           +ILL+ D+ SP+VK   KM   +FI+N R     ++I  + +  +Y+ I
Sbjct: 267 LILLSIDLTSPHVK--NKMSKREFIRNTRRA--AQNISEDFVGHLYDNI 311


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 54/170 (31%), Positives = 95/170 (55%), Gaps = 8/170 (4%)

Query: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618
           +A  L + +G  +  +  +L  +   F+R V +  +    F    LD ALR F   + + 
Sbjct: 591 LASRLYRLEGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649

Query: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678
           GE Q+ ER++  FS+R+  CNPG+   F + D++  L  AI+LLNTD++  N+   + M 
Sbjct: 650 GETQERERILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMS 704

Query: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK--TNEDHVSQVQKVE 726
            ++FI NL G+ DG + P+E+L  +Y  IR  +L+   +E+  ++ +K +
Sbjct: 705 CQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQ 754


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 60/182 (32%), Positives = 96/182 (52%), Gaps = 10/182 (5%)

Query: 560 AHFLLQR----KGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHI 615
           AH L +R    +G  R  +   LG +  +F+R V    +   DFS + LD ALR F    
Sbjct: 314 AHRLARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAF 372

Query: 616 RVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPER 675
            + GE Q+ ER++  FS+RYC CNP       + D I  L  A++LLNTD++  N+   +
Sbjct: 373 PLMGETQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLHGHNI--GK 427

Query: 676 KMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPI 735
           KM  + FI NL  ++DG+D  +++L  +Y  I+  +L+   D     + + +L+  K   
Sbjct: 428 KMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGT 487

Query: 736 GS 737
           G+
Sbjct: 488 GT 489


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 54  LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 112

Query: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678
           GE Q+ ER++  FS RY  CNP  +    + D +  L  AI+LLNTD++  N+   +KM 
Sbjct: 113 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 167

Query: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 734
            ++FI NL+GV++G D  +++L  +Y  I+  +L+      E   S  +  E+   G  P
Sbjct: 168 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 227

Query: 735 --IGSLHPGLGCVLSLPH 750
             I  +       L +PH
Sbjct: 228 KTISRIGSTTNPFLDIPH 245


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 646

Query: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678
           GE Q+ ER++  FS RY  CNP  +    + D +  L  AI+LLNTD++  N+   +KM 
Sbjct: 647 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 701

Query: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 734
            ++FI NL+GV++G D  +++L  +Y  I+  +L+      E   S  +  E+   G  P
Sbjct: 702 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 761

Query: 735 --IGSLHPGLGCVLSLPH 750
             I  +       L +PH
Sbjct: 762 KTISRIGSTTNPFLDIPH 779


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 6/155 (3%)

Query: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618
           +A  L +  G  +  +   LG +   F++ V    +    F+ M LD+ALR F   + + 
Sbjct: 561 LAKRLYRLDGFRKADVARHLG-KNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALM 619

Query: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678
           GE Q+ ER++  FSQRY  CNP       + D    L  A++LLNTD++  N+   ++M 
Sbjct: 620 GETQERERVLAHFSQRYFQCNP---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMT 674

Query: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK 713
             DFI NL G++DG D PRE+L  +Y  I+  +L+
Sbjct: 675 CGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQ 709


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 68/315 (21%), Positives = 121/315 (38%), Gaps = 16/315 (5%)

Query: 213 ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD 272
           +  D S  +     + SSD +D+ ++  D+ S   KS ++S D      S  +  + + D
Sbjct: 594 DSSDSSNSSDSSDSSDSSDSSDS-SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652

Query: 273 AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL 332
            + + D+   +             ++S SD +   D  + S     S++ D   S++SD 
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712

Query: 333 RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL 392
              +  ++    + +   + +D+  S  S+ S +  +     +          SDSS D 
Sbjct: 713 S-DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS-DS 770

Query: 393 SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPP-------RPL 445
           SD S+       S    S      S        +  S   +  +                
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830

Query: 446 DSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTY 505
           DS  + N S +  S   SD SD D+ + + +SNS+D+ + S  S+S DS      S  + 
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS------SDSSD 884

Query: 506 HKEARNSWDSPAFSN 520
             E+ NS DS   SN
Sbjct: 885 SNESSNSSDSSDSSN 899



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 66/307 (21%), Positives = 113/307 (36%), Gaps = 21/307 (6%)

Query: 211  SPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPA 270
            S +  D S  +     + SSD +D+    + + S      ++S D   +  S  +  + +
Sbjct: 773  SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS 832

Query: 271  LDAARARDTEPQT-ALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGD-RPSST 328
             D++ + D+   + +  G D    +   +S S  +   D  + S     S + D   SS 
Sbjct: 833  SDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSS--DSSDSSNSSDSSDSSDSNESSN 890

Query: 329  ESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDS 388
             SD    +  +  D    ++  D +D+  S  S+ S    +           +    S +
Sbjct: 891  SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDN----------SNSSDSSN 940

Query: 389  SVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSH 448
            S D SD S+  +    S    S      S  +   S    +                DS 
Sbjct: 941  SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS-----DSS 995

Query: 449  LAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKE 508
             + + S +  S   SD SD  N S   +SNS+D+ N S  S S DS      S  +   +
Sbjct: 996  DSSDSSNSSDSSDSSDSSDSSNSS--DSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1053

Query: 509  ARNSWDS 515
            + NS DS
Sbjct: 1054 SSNSSDS 1060



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 67/331 (20%), Positives = 122/331 (36%), Gaps = 11/331 (3%)

Query: 189  SSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVK 248
            S+  +    S ++DGS   +    +  + S+ +     + SSD +D+    E + S    
Sbjct: 836  SNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSS 895

Query: 249  SLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYID 308
              + S D   +  S  ++ + + +++ + ++   +             ++  SD +   D
Sbjct: 896  DSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSD 955

Query: 309  EEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQ 368
                S     S + D  SS  SD    +  +  D    +   D +D+  S  S+ S +  
Sbjct: 956  SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS--DSSDSSDSSDSSDSSNSSDSSDSSDSS 1013

Query: 369  EQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPK 428
            +     +          SDSS D SD S+       S    S      S        +  
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSS-DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1072

Query: 429  SLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINS----TSNSNDTIN 484
            S   +  +         DS  + N S +  S   SD SD  + S +S    +SNS+D+ +
Sbjct: 1073 SDSSDSSD----SSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128

Query: 485  CSSESSSRDSLREQTLSKQTYHKEARNSWDS 515
             S  S S DS      S  +   ++ +S DS
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDS 1159



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 64/324 (19%), Positives = 118/324 (36%), Gaps = 28/324 (8%)

Query: 201 NDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNC 260
           +D S   +  S +  D S+ +   + + SSD +D+      + S      ++S D + + 
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699

Query: 261 RSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQ 320
            S  + ++   D++ + D+    +         D   +S S  +   D  + S     S 
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS--DSSDSSNSSDSSD 757

Query: 321 AGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLL 380
           + D  +S++S                +   D +D+  S  S+ S +        +     
Sbjct: 758 SSDSSNSSDS----------------SDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSS 801

Query: 381 TIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPR 440
                SDSS D SD S+  S     +   S      +      S         +   R  
Sbjct: 802 DSSNSSDSS-DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD 860

Query: 441 PPRPLDSHLAINGSANRQSKSESDYSDGDN-----DSINS----TSNSNDTINCSSESSS 491
                DS  + + S +  S   SD ++  N     DS NS    +S+S+++ + S  S+S
Sbjct: 861 SSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNS 920

Query: 492 RDSLREQTLSKQTYHKEARNSWDS 515
            DS      S  +   ++ NS DS
Sbjct: 921 SDSSESSNSSDNSNSSDSSNSSDS 944



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 60/311 (19%), Positives = 116/311 (37%), Gaps = 40/311 (12%)

Query: 211  SPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPA 270
            S +  D S+ +     + SSD +D+      + S    + ++S D      S  ++ + +
Sbjct: 752  SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDS-----SNSSDSSNS 806

Query: 271  LDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTES 330
             D++ + D+    + +  D       +++ SD +   +  + S     S   D  SS  S
Sbjct: 807  SDSSDSSDSSDSDSSNSSD-------SSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRS 859

Query: 331  DLRLRAGGA-APDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSS 389
            D    +  + + D    +   D +D++ S  S+ S +                +  S  S
Sbjct: 860  DSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSS-----------DSDSSDS 908

Query: 390  VDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHL 449
             + SD S+  +    S    S      S        +  S                DS  
Sbjct: 909  SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS----------------DSSN 952

Query: 450  AINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEA 509
            + + S +  S + SD SD ++   + +SNS+D+ + S  S S DS      S  +   ++
Sbjct: 953  SSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1012

Query: 510  RNSWDSPAFSN 520
             +S +S   SN
Sbjct: 1013 SDSSNSSDSSN 1023



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 68/338 (20%), Positives = 127/338 (37%), Gaps = 14/338 (4%)

Query: 180  SFEGPEKVHSSYFEGKQVSVTNDGSQLG-ALVSPECGDLSEPTTLKSPAPSSDFADAITE 238
            S +  +  +SS  +    S ++D S    +  S E  + S+ +     + SSD +D+   
Sbjct: 891  SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950

Query: 239  LEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTA 298
               + S      + S D + +  S  ++ + + D++ + D+   +      +      ++
Sbjct: 951  SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1010

Query: 299  SYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTS 358
              SD +   D    S     S + D   S++S     +  ++ D    +   D +D+  S
Sbjct: 1011 DSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS-DSSNSSDSSDSSDSSDS 1069

Query: 359  CRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSP 418
              S+ S +  +     +          SDSS D SD S+       S    S      S 
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSS-DSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128

Query: 419  KHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINS-TS 477
                   +  S   +            DS  + + S +  S   SD SD  + S +S +S
Sbjct: 1129 SSDSSDSSDSSNSSDSS----------DSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1178

Query: 478  NSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDS 515
            NS+D+ + S  S S DS      S  +   ++ +S DS
Sbjct: 1179 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1216



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 62/324 (19%), Positives = 125/324 (38%), Gaps = 31/324 (9%)

Query: 193  EGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAE 252
            +  + S ++D S        +  D S  +     + SSD +++    +++ S    + ++
Sbjct: 884  DSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSD 943

Query: 253  SIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEEL 312
            S D + +  S  ++ + + D++ + D+    +    D     + + S SD +   D  + 
Sbjct: 944  SSDSSDSSNS--SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDS-SDSSDSSDSSDS 1000

Query: 313  SPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRL 372
            S     S + D   S+ S     +  ++       +  D +D+  S  S+ S +  +   
Sbjct: 1001 SNSSDSSDSSDSSDSSNSSDSSNSSDSS-------NSSDSSDSSDSSDSSDSSDSSDSS- 1052

Query: 373  RVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPR 432
                         S +S D SD S+       S    S    + S      + +  S   
Sbjct: 1053 ------------DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSS 1100

Query: 433  EEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINS-TSNSNDTINCSSESSS 491
            +  +         DS  + + S +  S + SD SD  + S +S +SNS+D+ + S  S S
Sbjct: 1101 DSSDSS-------DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDS 1153

Query: 492  RDSLREQTLSKQTYHKEARNSWDS 515
             DS      S  +   ++ +S DS
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSDS 1177



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 71/334 (21%), Positives = 126/334 (37%), Gaps = 26/334 (7%)

Query: 198  SVTNDGSQLGALVSPECGDLSEPTTLKSPAP-SSDFADAITELEDAFSRQVKSLAESIDD 256
            S ++D S      S +  D S   +  S +  SSD +D+    + + S    + ++S D 
Sbjct: 699  SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758

Query: 257  ALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPL 316
            + +  S  ++ + + D++ + D+   +  +   +      +++ SD +   D  + S   
Sbjct: 759  SDSSNS--SDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816

Query: 317  PLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEH 376
                +    SS  SD    +  +  D    +   D +D+D+S RS  S            
Sbjct: 817  DSDSSNSSDSSNSSDSSDSSNSS--DSSDSSDSSDGSDSDSSNRSDSSNSSDSSD----- 869

Query: 377  LPLLTIEPPSDSSVDLSDRSERGSLKRQS-AYERSLGGQQGSPKHGPHSGAPKSLPREEP 435
                     S +S D SD S+       S + + S      S      S +  S    + 
Sbjct: 870  ------SSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDS 923

Query: 436  ELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDN--DSINS-------TSNSNDTINCS 486
                      +S  + N S +  S   S+ SD  N  DS NS       +S+S+D+ N S
Sbjct: 924  SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983

Query: 487  SESSSRDSLREQTLSKQTYHKEARNSWDSPAFSN 520
              S S DS      S  +   ++ +S DS   SN
Sbjct: 984  DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 58/298 (19%), Positives = 111/298 (37%), Gaps = 20/298 (6%)

Query: 211  SPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAP- 269
            S +  D S+ +     + SSD +D+    + + S    + ++S D + +  S  + ++  
Sbjct: 991  SSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSD 1050

Query: 270  ------ALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGD 323
                  + D++ + D+   +             ++  SD +   D  + S     S + D
Sbjct: 1051 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSD 1110

Query: 324  RPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIE 383
               S++S     +  ++          D +D+  S  S+ S +  E     +        
Sbjct: 1111 SSDSSDSSDSSNSSDSSDS-------SDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSS 1163

Query: 384  PPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPR 443
              SDSS D SD S+  +    S    S      S        +  S   +  +       
Sbjct: 1164 DSSDSS-DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS-- 1220

Query: 444  PLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLS 501
              DS  + + S + +S   SD SD  +DS NS+ +S+ + +  S S S D    Q+ S
Sbjct: 1221 --DSSDSSDSSDSNESSDSSDSSDS-SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 113/522 (21%), Positives = 185/522 (35%), Gaps = 87/522 (16%)

Query: 20  DSGVEGEAPSSETGTSLDSPSAY-PQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQR 78
           D G E +  SS  G + DS   Y P+G   P + +  D    +   + G+     G Q+ 
Sbjct: 284 DHGKEDDHDSS-IGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDN-GSQRI 341

Query: 79  TRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAA 138
               KL H  S   K+ E    K S    E++ +    QDK +E+     G R +T+   
Sbjct: 342 EDTQKLNHRES---KRVENRITKES----ETHAVGKS-QDKGIEIKGPSSGNRNITKEVG 393

Query: 139 RTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLS--NMRMQ---FSFEGPEKVHSSYFE 193
           +                   +   E++    ++L   N++ Q    + EGP +       
Sbjct: 394 KG------------------NEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEP--- 432

Query: 194 GKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFA----DAITELEDAFSRQVKS 249
           G +V  +N GS   +    +  D  + +       SSD +    DA +E ++  S +  +
Sbjct: 433 GNKVGHSNTGSDSNS-DGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDA 491

Query: 250 LAESIDDALNCRSLHTEEAPALDAARARDTEPQTAL----HGMDHRKLDEMTASYSDVTL 305
              S +   N     ++ A   D+    DT    +     +G D     +     SD + 
Sbjct: 492 SYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSS- 550

Query: 306 YIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSL 365
              + + S     S + D   S  SD    +   + D    +   D +D+D+S  S  S 
Sbjct: 551 ---DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSD----SDSSDSSDSDSSDSSNSSD 603

Query: 366 ERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSG 425
                               SDSS D SD S+    K  S+   S      S      S 
Sbjct: 604 SSDS----------------SDSS-DSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSN 646

Query: 426 APKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINC 485
           +  S    +           DS  + N S +  S   SD S   + S +S S+ +   + 
Sbjct: 647 SSDSSDNSDSS---------DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697

Query: 486 SSESS-------SRDSLREQTLSKQTYHKEARNSWDSPAFSN 520
           SSESS       S  S    + +  +   ++ NS DS   SN
Sbjct: 698 SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN 739



 Score = 37.4 bits (85), Expect = 0.068
 Identities = 55/271 (20%), Positives = 100/271 (36%), Gaps = 20/271 (7%)

Query: 211  SPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPA 270
            S +  D S+ +   + + SSD +D+    + + S      +ES D + +  S  ++ + +
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS--SDSSDS 1099

Query: 271  LDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTES 330
             D++ + D+   +             ++  SD +   D    S     S++ D   S++S
Sbjct: 1100 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDS 1159

Query: 331  DLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSV 390
                       D    +   D +D+  S  S+ S +  +     +          SDSS 
Sbjct: 1160 S----------DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS- 1208

Query: 391  DLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLA 450
            D SD S+       S    S    + S        +  S   +  +         DS   
Sbjct: 1209 DSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDS--- 1265

Query: 451  INGSANRQSKS---ESDYSDGDNDSINSTSN 478
             N  ++ QSKS    ++ SD D+DS  S SN
Sbjct: 1266 -NDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 65/329 (19%), Positives = 120/329 (36%), Gaps = 23/329 (6%)

Query: 189  SSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVK 248
            S+  +    S ++D     +  S    D S+ +     + SSD +D      D+ +R   
Sbjct: 804  SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS--DSSNRSDS 861

Query: 249  SLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTAS-YSDVTLYI 307
            S +    D+ +  +       +     +  ++   + +  D    D   +S  SD +   
Sbjct: 862  SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS 921

Query: 308  DEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLER 367
            D  E S     S + D  +S++S           D    ++  D +++  S  S+ S + 
Sbjct: 922  DSSESSNSSDNSNSSDSSNSSDSS----------DSSDSSNSSDSSNSSDSSNSSDSSDS 971

Query: 368  QEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAP 427
                   +          SDSS D SD S+       S    S      S      + + 
Sbjct: 972  NSS----DSSDSSNSSDSSDSS-DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD 1026

Query: 428  KSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINS-TSNSNDTINCS 486
             S   +  +         DS  + + S +  S + SD SD  + S +S +S+S+D+ + S
Sbjct: 1027 SSNSSDSSDSSDSS----DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082

Query: 487  SESSSRDSLREQTLSKQTYHKEARNSWDS 515
              S S DS      S  +   ++ +S DS
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111



 Score = 33.5 bits (75), Expect = 0.98
 Identities = 54/285 (18%), Positives = 107/285 (37%), Gaps = 6/285 (2%)

Query: 211  SPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPA 270
            S    D S  +   + + SSD +D+    + + S      + S D + +  S  ++ + +
Sbjct: 1015 SSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS--SDSSDS 1072

Query: 271  LDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTES 330
             D++ + D+   +      +      ++  SD +   D  + S     S + D   S++S
Sbjct: 1073 SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132

Query: 331  DLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSV 390
                 +  ++ D    +   D +D+  S  S+ S +  +     +          SDSS 
Sbjct: 1133 SDSSDSSNSS-DSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS- 1190

Query: 391  DLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLA 450
            D SD S+       S    S      S        +  S   E  +          S+ +
Sbjct: 1191 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSS 1250

Query: 451  INGSANRQSKSESDYSDGDNDSINSTSNSNDT-INCSSESSSRDS 494
             +  ++  S S SD +D ++DS + + N N+   +  S+S   DS
Sbjct: 1251 DSSDSSDSSDSTSDSND-ESDSQSKSGNGNNNGSDSDSDSEGSDS 1294


>gi|40788007 FYN binding protein (FYB-120/130) isoform 2 [Homo
           sapiens]
          Length = 783

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 47/231 (20%), Positives = 86/231 (37%), Gaps = 29/231 (12%)

Query: 281 PQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAA 340
           P  + +G + ++  ++ A+ +     I++EEL+   P ++    PS      +L  GG  
Sbjct: 273 PGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPS------KLTVGGP- 325

Query: 341 PDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDS-----SVDLSDR 395
              W  + +++K D +++      L            PL T+ PP        +VDL+  
Sbjct: 326 ---WGQSQEKEKGDKNSATPKQKPLP-----------PLFTLGPPPPKPNRPPNVDLTKF 371

Query: 396 SERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRP---RPPRPLDSHLAIN 452
            +  S    S  + S       P    H  +   LP   P   P    PPR +     + 
Sbjct: 372 HKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLK 431

Query: 453 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQ 503
              N  ++    +SDG  +      +  +T      S  R+  RE+   K+
Sbjct: 432 SPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKR 482


>gi|42476118 FYN binding protein (FYB-120/130) isoform 1 [Homo
           sapiens]
          Length = 829

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 47/231 (20%), Positives = 86/231 (37%), Gaps = 29/231 (12%)

Query: 281 PQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAA 340
           P  + +G + ++  ++ A+ +     I++EEL+   P ++    PS      +L  GG  
Sbjct: 273 PGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPS------KLTVGGP- 325

Query: 341 PDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDS-----SVDLSDR 395
              W  + +++K D +++      L            PL T+ PP        +VDL+  
Sbjct: 326 ---WGQSQEKEKGDKNSATPKQKPLP-----------PLFTLGPPPPKPNRPPNVDLTKF 371

Query: 396 SERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRP---RPPRPLDSHLAIN 452
            +  S    S  + S       P    H  +   LP   P   P    PPR +     + 
Sbjct: 372 HKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLK 431

Query: 453 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQ 503
              N  ++    +SDG  +      +  +T      S  R+  RE+   K+
Sbjct: 432 SPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKR 482


>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein
           [Homo sapiens]
          Length = 3969

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 34/150 (22%), Positives = 62/150 (41%), Gaps = 19/150 (12%)

Query: 306 YIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSL 365
           +I++E+  PP+ +++    P+S  S     + G++    A +    +  +D+S  S+PS+
Sbjct: 428 FIEDEDYDPPIKIARLESTPNSRFS---APSCGSSEKSSAASQHSSQMSSDSSRSSSPSV 484

Query: 366 ERQEQRLRVEHLPLL--------TIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQ--- 414
           +        E + +L         + PP   S    + S     +R S  ERS G +   
Sbjct: 485 DTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTK 544

Query: 415 -----QGSPKHGPHSGAPKSLPREEPELRP 439
                Q +P+    S  P  L    P L+P
Sbjct: 545 KLSTLQSAPQQQTSSSPPPPLLTPPPPLQP 574



 Score = 30.4 bits (67), Expect = 8.3
 Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 11/89 (12%)

Query: 308 DEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLER 367
           D  E+ PPLP+SQ+   P +  +D R R        ++++ +   + T T   ST     
Sbjct: 505 DTPEVHPPLPISQS---PENESNDRRSRR-------YSVSERSFGSRT-TKKLSTLQSAP 553

Query: 368 QEQRLRVEHLPLLTIEPPSDSSVDLSDRS 396
           Q+Q       PLLT  PP   +  +SD +
Sbjct: 554 QQQTSSSPPPPLLTPPPPLQPASSISDHT 582


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 106/465 (22%), Positives = 166/465 (35%), Gaps = 86/465 (18%)

Query: 75  QQQRTRRPKLQHSTSIL--RKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRL 132
           Q ++ +R   +H   +L  R++  EE  ++ R L E      +L+ +Q     R Y  ++
Sbjct: 372 QLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQM 431

Query: 133 ----VTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVH 188
                 R A    +   +Q +  +  ERL+  + + R     +    + Q   E     H
Sbjct: 432 RREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYH 491

Query: 189 SSYFEGKQVSV-------TNDGSQLGALVSPE-----CGDLSEPTTLKSPAPSSDFADAI 236
             Y EG   S          + S+L    SP         +S+P     P  S  F+  I
Sbjct: 492 --YKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNL---PPRSESFS--I 544

Query: 237 TELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEP-------QTALHGMD 289
           + ++ A   +   +   +D  +        + PAL A+++   +P       Q AL+   
Sbjct: 545 SGVQPA---RTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTS 601

Query: 290 HRKLDEMTASYSDVTLYIDEEELSPPLPLS-QAGDRPS--STESDLR----LRAGGAAPD 342
           HR   EM    SD T        +PPLP   +  DR S    E D+      R    +P 
Sbjct: 602 HRV--EMPRQNSDPT------SENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISP- 652

Query: 343 YWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLK 402
             ALA K    +      S        Q +R  +  L   EP  +S +  +      S  
Sbjct: 653 --ALARKNSPGNG-----SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSS 705

Query: 403 RQSAYERSLGGQQGSPKHGPHS-----------GAPKSLPREEPELRP-------RPPRP 444
             S+   S GG Q   + G              G+P  LP E  +++P       RP RP
Sbjct: 706 TPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPV-LPHEPAKVKPEESRDITRPSRP 764

Query: 445 LD--------SHLAINGSANRQSKSESDYSDGDNDSINSTSNSND 481
            D          L I    NR  K  +DYS    +S +S     D
Sbjct: 765 ADLTALAKELRELRIE-ETNRPMKKVTDYSSSSEESESSEEEEED 808


>gi|55749769 CWC22 spliceosome-associated protein homolog [Homo
           sapiens]
          Length = 908

 Score = 39.7 bits (91), Expect = 0.014
 Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 7/81 (8%)

Query: 427 PKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCS 486
           PK +  ++P++      P       + S++  S SESD SD D+DS +S+S S+   + S
Sbjct: 651 PKVIVAQKPDVEQNKSSP-------SSSSSASSSSESDSSDSDSDSSDSSSESSSEESDS 703

Query: 487 SESSSRDSLREQTLSKQTYHK 507
           S  SS  S     + K+ + K
Sbjct: 704 SSISSHSSASANDVRKKGHGK 724


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 39.7 bits (91), Expect = 0.014
 Identities = 70/308 (22%), Positives = 106/308 (34%), Gaps = 57/308 (18%)

Query: 212  PECGDLSEPTTLKSPAPSSDFADAITE--LEDAFSRQVKSLAESIDDALNCRSLHTEEAP 269
            P     S  T+ ++P+PSS    A ++  L  A  +    +  +  D   C    T    
Sbjct: 2411 PSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVA 2470

Query: 270  ALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTE 329
               +  +      T+  G DH  +  + A               P +P S  G+ P+ST 
Sbjct: 2471 GSQSLSSGAVATTTSSAG-DHNGMLSVPA---------------PGVPHSDVGEPPASTG 2514

Query: 330  SDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSS 389
            +          P       KE ++ + +S  S+ S                     S SS
Sbjct: 2515 AQQPSALAALQPA------KERRSSSSSSSSSSSSSSSSSS------------SSSSSSS 2556

Query: 390  VDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHL 449
               S  SE  SL  Q          +  P   P   APK   RE      RPP P     
Sbjct: 2557 GSSSSDSEGSSLPVQPEV-----ALKRVPSPTP---APKEAVREG-----RPPEPTP--- 2600

Query: 450  AINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEA 509
                 A R+ +S S  S   + S +S+S+S+ + + SS SSS  S    + S  +  K  
Sbjct: 2601 -----AKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG 2655

Query: 510  RNSWDSPA 517
              +   PA
Sbjct: 2656 PQALPKPA 2663



 Score = 30.8 bits (68), Expect = 6.4
 Identities = 29/100 (29%), Positives = 41/100 (41%), Gaps = 5/100 (5%)

Query: 20   DSGVEGEAPSSET--GTSLDSPSAYPQGPLVPGSSL---SPDHYEHTSVGAYGLYSGPPG 74
            DS  E +AP+       S    S+  +GP   GSS    SP+H   +     G  S P  
Sbjct: 1619 DSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEP 1678

Query: 75   QQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSS 114
            + +    P+ + S S      +    +RSRS S S E  S
Sbjct: 1679 KTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRS 1718


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score = 39.3 bits (90), Expect = 0.018
 Identities = 107/472 (22%), Positives = 168/472 (35%), Gaps = 98/472 (20%)

Query: 75  QQQRTRRPKLQHSTSILRKQAE-------------EEAIKRSRSLSESYELSSDLQDKQV 121
           ++QR R  + Q     LRKQ E             EE  +R+    E      + + +Q+
Sbjct: 399 KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQL 458

Query: 122 EMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSF 181
           E+L+++     +    A  ++   +Q +  +  ERL+  + + R     +    + Q   
Sbjct: 459 EILQQQ-----LLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPV 513

Query: 182 EGPEKVHSSYFEGKQVSV-------TNDGSQLGALVSPE-----CGDLSEPTTLKSPAPS 229
           E     H  Y EG   S          + S+L    SP         +S+P     P  S
Sbjct: 514 EKKPLYH--YKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNL---PPRS 568

Query: 230 SDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEP-------Q 282
             F+  I+ ++ A   +   +   +D  +        + PAL A+++   +P       Q
Sbjct: 569 ESFS--ISGVQPA---RTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQ 623

Query: 283 TALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLS-QAGDRPS--STESDLR----LR 335
            AL+   HR   EM    SD T        +PPLP   +  DR S    E D+      R
Sbjct: 624 EALNVTSHRV--EMPRQNSDPT------SENPPLPTRIEKFDRSSWLRQEEDIPPKVPQR 675

Query: 336 AGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDR 395
               +P   ALA K    +      S        Q +R  +  L   EP  +S +  +  
Sbjct: 676 TTSISP---ALARKNSPGNG-----SALGPRLGSQPIRASNPDLRRTEPILESPLQRTSS 727

Query: 396 SERGSLKRQSAYERSLGGQQGSPKHGPHS-----------GAPKSLPREEPELRP----- 439
               S    S+   S GG Q   + G              G+P  LP E  +++P     
Sbjct: 728 GSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPV-LPHEPAKVKPEESRD 786

Query: 440 --RPPRPLD--------SHLAINGSANRQSKSESDYSDGDNDSINSTSNSND 481
             RP RP D          L I    NR  K  +DYS    +S +S     D
Sbjct: 787 ITRPSRPADLTALAKELRELRIE-ETNRPMKKVTDYSSSSEESESSEEEEED 837


>gi|51599156 chromodomain helicase DNA binding protein 4 [Homo
           sapiens]
          Length = 1912

 Score = 38.5 bits (88), Expect = 0.031
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 2/84 (2%)

Query: 427 PKSLPREEPELRPRPPR--PLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTIN 484
           PK  PR     +P+P +  PL   L   GS  ++S SE D  D ++D  +++ NS    +
Sbjct: 274 PKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSD 333

Query: 485 CSSESSSRDSLREQTLSKQTYHKE 508
            S+  SSR   + +T  K+   +E
Sbjct: 334 GSTSRSSRSRKKLRTTKKKKKGEE 357


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score = 38.1 bits (87), Expect = 0.040
 Identities = 91/422 (21%), Positives = 147/422 (34%), Gaps = 55/422 (13%)

Query: 75  QQQRTRRPKLQHSTSIL--RKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRL 132
           Q ++ +R   +H   +L  R++  EE  ++ R L E      +L+ +Q     R Y  ++
Sbjct: 372 QLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQM 431

Query: 133 ----VTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVH 188
                 R A    +   +Q +  +  ERL+  + + R     +    + Q   E     H
Sbjct: 432 RREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYH 491

Query: 189 SSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVK 248
             Y EG   S     ++          ++     +KS  P      A+T  +    +  K
Sbjct: 492 --YKEGMSPSEKPAWAK----------EIPHLVAVKSQGP------ALTASQSVHEQPTK 533

Query: 249 SLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYID 308
            L+    +ALN  S H  E P  ++    +  P           L      +   +    
Sbjct: 534 GLS-GFQEALNVTS-HRVEMPRQNSDPTSENPP-----------LPTRIEKFDRSSWLRQ 580

Query: 309 EEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQ 368
           EE++ P +P       P+    +         P    L  +  +A      R+ P LE  
Sbjct: 581 EEDIPPKVPQRTTSISPALARKNSPGNGSALGP---RLGSQPIRASNPDLRRTEPILESP 637

Query: 369 EQRLRVEHLPLLTIEPPSDSSVDLSDR-SERGSLKRQSAYERSLGGQQGSPKHGPHSGAP 427
            QR         +      SS   S   S+ GS +R     R+    +GSP   PH  A 
Sbjct: 638 LQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRV--RANSKSEGSPVL-PHEPA- 693

Query: 428 KSLPREEPELRPRPPRPLD--------SHLAINGSANRQSKSESDYSDGDNDSINSTSNS 479
           K  P E  ++  RP RP D          L I    NR  K  +DYS    +S +S    
Sbjct: 694 KVKPEESRDIT-RPSRPADLTALAKELRELRIE-ETNRPMKKVTDYSSSSEESESSEEEE 751

Query: 480 ND 481
            D
Sbjct: 752 ED 753


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,909,942
Number of Sequences: 37866
Number of extensions: 1921000
Number of successful extensions: 7625
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 7122
Number of HSP's gapped (non-prelim): 499
length of query: 963
length of database: 18,247,518
effective HSP length: 112
effective length of query: 851
effective length of database: 14,006,526
effective search space: 11919553626
effective search space used: 11919553626
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.