Guide to the Human Genome
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Search of human proteins with 50428917

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50428917 epithelial stromal interaction 1 isoform 1 [Homo
sapiens]
         (410 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50428917 epithelial stromal interaction 1 isoform 1 [Homo sap...   821   0.0  
gi|15147248 epithelial stromal interaction 1 isoform 2 [Homo sap...   603   e-173
gi|148746195 trichohyalin [Homo sapiens]                               66   7e-11
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    64   2e-10
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    64   2e-10
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    64   2e-10
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    64   2e-10
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    62   1e-09
gi|148806928 hypothetical protein LOC57482 [Homo sapiens]              55   1e-07
gi|4505101 microtubule-associated protein 7 [Homo sapiens]             55   1e-07
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre...    54   2e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    53   6e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     51   2e-06
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    51   2e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     50   3e-06
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    50   3e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    50   3e-06
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    49   6e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    49   6e-06
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]         49   1e-05
gi|81295809 pericentrin [Homo sapiens]                                 48   1e-05
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    48   2e-05
gi|134152708 arginine and glutamate rich 1 [Homo sapiens]              48   2e-05
gi|157266264 pleckstrin homology-like domain, family B, member 3...    48   2e-05
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    47   3e-05
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ...    47   4e-05
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ...    47   4e-05
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ...    47   4e-05
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ...    47   4e-05
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                 47   4e-05

>gi|50428917 epithelial stromal interaction 1 isoform 1 [Homo
           sapiens]
          Length = 410

 Score =  821 bits (2120), Expect = 0.0
 Identities = 410/410 (100%), Positives = 410/410 (100%)

Query: 1   MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAG 60
           MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAG
Sbjct: 1   MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAG 60

Query: 61  QRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVR 120
           QRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVR
Sbjct: 61  QRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVR 120

Query: 121 QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRRE 180
           QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRRE
Sbjct: 121 QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRRE 180

Query: 181 AFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSL 240
           AFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSL
Sbjct: 181 AFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSL 240

Query: 241 KAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGG 300
           KAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGG
Sbjct: 241 KAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGG 300

Query: 301 LEQSGGCWNMNSGNSWGSLLVFSRHLRVYEKILTPIWPSSTDLEKPHEMLFLNVILFSLT 360
           LEQSGGCWNMNSGNSWGSLLVFSRHLRVYEKILTPIWPSSTDLEKPHEMLFLNVILFSLT
Sbjct: 301 LEQSGGCWNMNSGNSWGSLLVFSRHLRVYEKILTPIWPSSTDLEKPHEMLFLNVILFSLT 360

Query: 361 VFTLISTAHTLDRAVRSDWLLLVLIYACLEELIPELIFNLYCQGNATLFF 410
           VFTLISTAHTLDRAVRSDWLLLVLIYACLEELIPELIFNLYCQGNATLFF
Sbjct: 361 VFTLISTAHTLDRAVRSDWLLLVLIYACLEELIPELIFNLYCQGNATLFF 410


>gi|15147248 epithelial stromal interaction 1 isoform 2 [Homo
           sapiens]
          Length = 307

 Score =  603 bits (1555), Expect = e-173
 Identities = 306/317 (96%), Positives = 306/317 (96%), Gaps = 11/317 (3%)

Query: 1   MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAG 60
           MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAG
Sbjct: 1   MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAG 60

Query: 61  QRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVR 120
           QRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVR
Sbjct: 61  QRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVR 120

Query: 121 QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRRE 180
           QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRRE
Sbjct: 121 QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRRE 180

Query: 181 AFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSL 240
           AFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSST           WARSWAYRDSL
Sbjct: 181 AFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSST-----------WARSWAYRDSL 229

Query: 241 KAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGG 300
           KAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGG
Sbjct: 230 KAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGG 289

Query: 301 LEQSGGCWNMNSGNSWG 317
           LEQSGGCWNMNSGNSWG
Sbjct: 290 LEQSGGCWNMNSGNSWG 306


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 55/206 (26%), Positives = 103/206 (50%), Gaps = 10/206 (4%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQL---QLMQSKYK 133
           R E Q   EQ+L   ++ + + R K      R     +SE ++R++Q+    QL++ + +
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555

Query: 134 QKLKREE-SVRIKKEAEEA--ELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKT 190
           ++L++E    R+K+E EE   +L K +  +R++  K E+++RL++ L+RE     +Q + 
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 191 AEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQK 250
            E   +L  E P+    Q  +   +    +   L R+    R    R   + EE R  Q+
Sbjct: 616 RE--QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE--QRLKREEEEERLEQR 671

Query: 251 MKDEQHQKSELLELKRQQQEQERAKI 276
           +K E  ++    EL  ++QEQ R +I
Sbjct: 672 LKREHEEERREQELAEEEQEQARERI 697



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 52/230 (22%), Positives = 103/230 (44%), Gaps = 15/230 (6%)

Query: 77   RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKL 136
            R E Q + E E   L +   Q R +      ++L   + E +  Q++Q QL + + ++K 
Sbjct: 1670 REEEQLLQEGEEQQLRR---QERDRKFREEEQQLRRQERERKFLQEEQ-QLRRQELERKF 1725

Query: 137  KREESVRIKKEAEEAELQKM--KAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFL 194
            + EE +R + E E+   Q+   K ++ E+     E+++L+   R   FRE +Q +     
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE 1785

Query: 195  SKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDE 254
             +L ++  DR   +      +    +L    RD  +   W        E+ ++L++ +D 
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKY--RWEEEQLQLEEQEQRLRQERDR 1843

Query: 255  QHQKSELL----ELKRQQQE---QERAKIHQTEHRRVNNAFLDRLQGKSQ 297
            Q++  E      + +R++QE   +E  K  Q   R++    + R Q + Q
Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 65/266 (24%), Positives = 116/266 (43%), Gaps = 24/266 (9%)

Query: 25  QDPSGRQGELSPVEDQ---REGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQ 81
           Q   G + E  P E+Q   RE LE   KG   E      +R+   +        R+ E  
Sbjct: 194 QSCKGHETEEFPDEEQLRRRELLELRRKG-REEKQQQRRERQDRVFQEEEEKEWRKRETV 252

Query: 82  RIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREES 141
              E+E    E+ + Q   +      R+L   +   E ++++Q Q       Q+L+RE+ 
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ-------QRLRREQQ 305

Query: 142 VRIKKEAEEAELQKMKAIQREKSNKLEEK-----KRLQENLRREAFREHQQYKTAEFLSK 196
           +R K+E E  E Q+ +  Q+E+  + EE+     +R QE  R +  R  Q+ +  E   +
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE--QQ 363

Query: 197 LNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQH 256
           L  E  +    Q      +    +   L R+    R    R   + ++ R+ Q+++ EQ 
Sbjct: 364 LRREQEEERREQQ--LRREQQLRREQQLRREQQLRREQQLR---REQQLRREQQLRREQQ 418

Query: 257 QKSELLELKRQQQEQERAKIHQTEHR 282
            + E  +L+R+Q+E+   + H+ E R
Sbjct: 419 LRRE-QQLRREQEEERHEQKHEQERR 443



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 65/293 (22%), Positives = 123/293 (41%), Gaps = 37/293 (12%)

Query: 38  EDQREGLEAAPKGPSRESVVHAGQR--RTSAYTLIAPNINRRNEIQRIAEQELANLEKWK 95
           E++RE  E   +   RE      QR  R      +   +    +++R  E+    L K +
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553

Query: 96  EQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQK 155
           E+ R +      RR    + E E R+ Q L+  + + +Q+LKRE+  R+++  +  E+++
Sbjct: 554 EEKRLEQ----ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609

Query: 156 M----KAIQREKSNKLEEKKRL-------QENLRREAFREHQQYKTAEFLSKLNTE---- 200
           +    +  QR K  + EE++R        QE  R++  R  QQ +  + L +   E    
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669

Query: 201 -----SPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENR--------K 247
                  +    +  +   +    +  I  R   W   W       A +++        +
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKW--QWQLESEADARQSKVYSRPRKQE 727

Query: 248 LQKMKDEQHQKSELLELKRQQQEQERA-KIHQTEHRRVNNAFLDRLQGKSQPG 299
            Q+ + EQ +K    E + Q QE+ERA +  Q E +R +  +  + + KS+ G
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 58/267 (21%), Positives = 122/267 (45%), Gaps = 38/267 (14%)

Query: 26  DPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAE 85
           +P  RQ E  P + +R+      K   +E  +  G+ ++     +      + + QR  E
Sbjct: 123 EPRDRQLEEEPGQRRRQ------KRQEQERELAEGEEQSEKQERL-----EQRDRQRRDE 171

Query: 86  QELANLEKWKEQNRAKPVHLVPRRLGGSQSET-----EVRQKQQLQLMQS--KYKQKLKR 138
           +     ++W+E+   +      +   G ++E      ++R+++ L+L +   + KQ+ +R
Sbjct: 172 ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRR 231

Query: 139 EESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLN 198
           E   R+ +E EE E +K + + R++  KL+E++  ++   RE   E +Q +  E   +L 
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ---RELQEEEEQLRKLE-RQELR 287

Query: 199 TESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQK 258
            E  +    Q               L R+    R        + EE R+ Q+ +++Q ++
Sbjct: 288 RERQEEEQQQQR-------------LRREQQLRRKQEEERREQQEERREQQERREQQEER 334

Query: 259 SELLELKRQQQE--QERAKIHQTEHRR 283
            E  +L+R+Q+E  +++ +  Q E RR
Sbjct: 335 REQ-QLRREQEERREQQLRREQEEERR 360



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 57/232 (24%), Positives = 108/232 (46%), Gaps = 35/232 (15%)

Query: 76  RRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQL-MQSKYKQ 134
           R  +++R  E+E    +  +EQ   +   L  RR    + E ++R++QQL+   Q + +Q
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQLRREQ 417

Query: 135 KLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFL 194
           +L+RE+ +R ++E E  E QK +  +RE+  K E+++R     R E    H+Q +  + L
Sbjct: 418 QLRREQQLRREQEEERHE-QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476

Query: 195 SKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDE 254
            +   E                         R   W +     +  + ++ R+ Q+++ E
Sbjct: 477 KRDQEEE------------------------RRERWLK--LEEEERREQQERREQQLRRE 510

Query: 255 QHQKSELLELKRQQQE---QERAKIHQTEHRRVNNAFLDRLQGKSQPGGLEQ 303
           Q ++ E   LKRQ++E   Q+R +  Q + RR      ++L  + +   LEQ
Sbjct: 511 QEERRE-QRLKRQEEEERLQQRLRSEQ-QLRREQEERREQLLKREEEKRLEQ 560



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 52/215 (24%), Positives = 98/215 (45%), Gaps = 47/215 (21%)

Query: 61   QRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVR 120
            +RR + Y   A     R E Q + E+E     + +E+ R +            + E + R
Sbjct: 884  RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ------------EQERQYR 931

Query: 121  QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKL---EEKKRLQENL 177
            +++QLQ    + +++L REE  + +++  E + +K K +Q+++   L    EK+R QE  
Sbjct: 932  EEEQLQ----QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE-- 985

Query: 178  RREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYR 237
            R + +RE ++ +  E   +L  E  ++                     R   W R +  +
Sbjct: 986  REKKYREEEELQQEE--EQLLREEREKR--------------------RRQEWERQYRKK 1023

Query: 238  DSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQE 272
            D L+ EE + L+    E+ +K  L E +RQ +E+E
Sbjct: 1024 DELQQEEEQLLR----EEREKRRLQERERQYREEE 1054



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 56/219 (25%), Positives = 97/219 (44%), Gaps = 30/219 (13%)

Query: 76   RRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQK 135
            RR E  R   +E   L +   Q R +      ++L   + E + R+++QL+  Q   +++
Sbjct: 1685 RRQERDRKFREEEQQLRR---QERERKFLQEEQQLRRQELERKFREEEQLR--QETEQEQ 1739

Query: 136  LKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLS 195
            L+R+E  R +K  EE +L+  +  Q+ +  + + K R +E LR+E  RE QQ ++ E   
Sbjct: 1740 LRRQE--RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE--REEQQLRSQESDR 1795

Query: 196  KLNTESPDRSACQSAVCGPQSST----WKLPILPRDHSWARSWAYRD-SLKAEEN----- 245
            K   E   R   +     PQ       W+   L  +    R    RD   +AEE      
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855

Query: 246  -----------RKLQKMKDEQHQKSELLELKRQQQEQER 273
                        + QK + E+ +K     ++RQQ+E++R
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 52/225 (23%), Positives = 94/225 (41%), Gaps = 35/225 (15%)

Query: 76  RRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRL--GGSQSETEVRQKQQLQLMQSKYK 133
           R+ E QR  E     LE+   Q R +      R L  G  QSE + R +Q+ +  + +  
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEEL 173

Query: 134 QKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEF 193
            + ++E   R ++ AEE +LQ  K  + E+    E+ +R +    R   RE +Q +  E 
Sbjct: 174 WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233

Query: 194 LSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKL----- 248
             ++  E  +                            + W  R+++  +E  KL     
Sbjct: 234 QDRVFQEEEE----------------------------KEWRKRETVLRKEEEKLQEEEP 265

Query: 249 QKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQ 293
           Q+ ++ Q ++ +L +L+RQ+  +ER +  Q + R      L R Q
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 44/213 (20%), Positives = 91/213 (42%), Gaps = 34/213 (15%)

Query: 61   QRRTSAYTLIAPNINRRNEIQRIAEQELANLE-KWKEQNRAKPVHLVPRRLGGSQSETEV 119
            Q R   +      + R+   ++  EQEL + E + K     + +H   R+    Q E ++
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540

Query: 120  RQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRR 179
            R++++ Q  +    +K + EE +R     +E E Q++   +R++  +LEE+K  ++   R
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLR-----QEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595

Query: 180  EAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDS 239
            +   + QQ +  E   +L  E                         RD  +         
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQE-------------------------RDRKFRED---EQL 1627

Query: 240  LKAEENRKLQKMKDEQHQKSELLELKRQQQEQE 272
            L+  E ++L + + ++    E  +L+RQ++EQ+
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 46/222 (20%), Positives = 104/222 (46%), Gaps = 37/222 (16%)

Query: 76   RRNEIQRIAEQELAN-------LEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLM 128
            +++E+Q+  EQ L          E+ ++    + +     +L G + ET  RQ+ + Q  
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081

Query: 129  QSKYKQK----LKREESVRIKKEAEEAELQKMKAIQREKSNKLEEK--KRLQENLRREAF 182
            + +  Q+    L REE  + +++  E + ++ + +Q+E+   L E+  KR ++ L R+ +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ-Y 1140

Query: 183  REHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKA 242
            RE ++ +  E   +L  E P++                     R     R +   + L+ 
Sbjct: 1141 REEEEVQQEE--EQLLREEPEKR--------------------RRQELERQYREEEELQQ 1178

Query: 243  EENRKLQKMKDEQHQKSELLELKRQQ-QEQERAKIHQTEHRR 283
            EE + L++ ++++ Q+ E    + ++ Q Q+R + ++ E +R
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 55/236 (23%), Positives = 104/236 (44%), Gaps = 30/236 (12%)

Query: 61   QRRTSAYTLIAPNINRRNEIQRIAEQELANL-EKWKEQNRAKPVH----LVPRRLGGSQS 115
            +R T     +     +  E+Q+  EQ L    EK + Q R +       L        + 
Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126

Query: 116  ETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSN-KLEEKKRLQ 174
            E E R++Q+L+  Q + ++++++EE   +++E E+   Q+++   RE+   + EE++ L+
Sbjct: 1127 EREKRRRQELE-RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185

Query: 175  ENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSW 234
            E   +      +QY+  E L +   +   R          Q S  K    P   +     
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDE-------DQRSDLKWQWEPEKEN----- 1233

Query: 235  AYRDS---LKAEENRKLQKMKDEQ----HQKSELLELKRQQQEQERAKIHQTEHRR 283
            A RD+    K  EN + ++++D Q      + +L  L  +QQE++R    + E RR
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR----EQERRR 1285



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 61/278 (21%), Positives = 120/278 (43%), Gaps = 41/278 (14%)

Query: 38   EDQREGL----EAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQR-----IAEQEL 88
            EDQR  L    E   +   R++ V+   R    +  +  +  R  + Q+     + EQ+ 
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276

Query: 89   ANLE----KWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQ-LQLMQSKYKQKLKREESVR 143
             + E    +W++++R  P      R    +++   R+ Q+  QL++ + ++K +R+E+ R
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336

Query: 144  IKKEAE----EAELQKMKAIQREKSNK-------------LEEKKRLQENLRREAF-REH 185
              +E E    E E Q ++  +R++  +             LEE++RL+   R   F +E 
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396

Query: 186  QQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEEN 245
            QQ +  E   +L  +   +   +      Q    K      +    R    R  L+ E  
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK--FREEEQQVRRQERERKFLEEE-- 1452

Query: 246  RKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
               Q+++ E+H+K    E ++  QE+E  ++H+ E  R
Sbjct: 1453 ---QQLRQERHRK--FREEEQLLQEREEQQLHRQERDR 1485



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 45/215 (20%), Positives = 94/215 (43%), Gaps = 34/215 (15%)

Query: 79   EIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQK--- 135
            ++ R   ++    E+ ++  + K +     +L G + E   RQ+++ +  + +  Q+   
Sbjct: 942  QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 136  -LKREESVRIKKEAEEAELQKMKAIQREKSNKLEE---KKRLQENLRREAFREHQQYKTA 191
             L REE  + +++  E + +K   +Q+E+   L E   K+RLQE  R   +RE ++ +  
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQE 1059

Query: 192  EFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKM 251
            E                  + G +  T       R     R +   + L+ EE + L++ 
Sbjct: 1060 E----------------EQLLGEERET------RRRQELERQYRKEEELQQEEEQLLREE 1097

Query: 252  KDE---QHQKSELLELKRQQQEQERAKIHQTEHRR 283
             ++   Q ++ +  E +  QQE+E+    + E RR
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 51/256 (19%), Positives = 104/256 (40%), Gaps = 49/256 (19%)

Query: 74   INRRNEIQRIAEQELANLEKWKE----------QNRAKPVHLVPRRLGGSQSETEVRQ-- 121
            + R+   ++  E+EL + E+ ++          Q R +      ++L   + E ++RQ  
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412

Query: 122  -----KQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKL-EEKKRLQE 175
                 +++ QL + +  +K + EE    ++E E   L++ + +++E+  K  EE++ LQE
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472

Query: 176  NLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWA 235
               ++  R+ +  K  E   +L  +  DR   +  +   +S   +   L  +    R   
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL---RSQEPERKFLEEEQQLHRQQR 1529

Query: 236  YRDSLKAE----------------------------ENRKLQKMKDEQHQKSELLELKRQ 267
             R  L+ E                            E  + Q  + E+ +K  L E K +
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589

Query: 268  QQEQERAKIHQTEHRR 283
            +QEQER  +   +  R
Sbjct: 1590 RQEQERKFMEDEQQLR 1605



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 56/259 (21%), Positives = 108/259 (41%), Gaps = 46/259 (17%)

Query: 36   PVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWK 95
            P+ +QRE          R+      Q+R   +        +R   +R  E+EL  LE+ +
Sbjct: 789  PLREQRE----------RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838

Query: 96   EQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVR----IKKEAEEA 151
            +  R +    +     G Q + E R+ Q+ Q    K++ +L+ E   R      K A + 
Sbjct: 839  QLQRRERAQQLQEEEDGLQEDQERRRSQE-QRRDQKWRWQLEEERKRRRHTLYAKPALQE 897

Query: 152  ELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFL----SKLNTESPDRSAC 207
            +L+K + + +E+  +L+ ++R  E  RR+   + +QY+  E L     +L  E  ++   
Sbjct: 898  QLRKEQQLLQEEEEELQREER--EKRRRQ--EQERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 208  QSAVCGPQSSTWKLPILPRDHSWARSWAYR---DSLKAEENRKLQKMKDEQHQKSELLEL 264
            Q                 R+  + +    +   + L  EE  K ++ + E+  + E    
Sbjct: 954  QE----------------RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE---- 993

Query: 265  KRQQQEQERAKIHQTEHRR 283
            +  QQE+E+    + E RR
Sbjct: 994  EELQQEEEQLLREEREKRR 1012



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 39/172 (22%), Positives = 77/172 (44%), Gaps = 10/172 (5%)

Query: 31   QGELSPVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELAN 90
            Q +L   E  R+ LE     P RE      Q R   +      + +  E Q++  QE   
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE-EEQLRQEREEQQLRSQESDR 1795

Query: 91   LEKWKEQNRAKPVHLVPRRLGGSQSETEVR-QKQQLQLMQSKYKQKLKREESVRIKK--- 146
              + +EQ R +      ++L   Q + + R +++QLQL + + + + +R+   R ++   
Sbjct: 1796 KFREEEQLRQEREE---QQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFA 1852

Query: 147  --EAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSK 196
              E    E Q++   + +K  +  E+K  +E++RR+   E +  +  E  S+
Sbjct: 1853 TQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904



 Score = 37.4 bits (85), Expect = 0.025
 Identities = 51/265 (19%), Positives = 109/265 (41%), Gaps = 35/265 (13%)

Query: 30  RQGELSPVEDQREGLEAAPKGPSR--------ESVVHAGQRRTSAYTLIAPNINRRNEIQ 81
           R+ EL   E++R   +   +   R        E     G++R SA     P +  + E Q
Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA----RPPLREQRERQ 797

Query: 82  RIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREES 141
             AE+     +++  +   K      RR    + E E++  ++ + +Q + + +  +EE 
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRR----EREKELQFLEEEEQLQRRERAQQLQEEE 853

Query: 142 VRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTES 201
             ++++ E    Q+ +  Q+ +    EE+KR +  L  +   + Q  K  + L +   E 
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE-EEEE 912

Query: 202 PDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDE---QHQK 258
             R   +                 R     R +   + L+ EE + L++ +++   Q ++
Sbjct: 913 LQREEREKR---------------RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957

Query: 259 SELLELKRQQQEQERAKIHQTEHRR 283
            +  + K+ QQ++E+    + E RR
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRR 982



 Score = 36.2 bits (82), Expect = 0.055
 Identities = 51/220 (23%), Positives = 92/220 (41%), Gaps = 32/220 (14%)

Query: 77   RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK--- 133
            R E Q++  QE       +EQ   +  H   R+    +   + R++QQL   +   K   
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERH---RKFREEEQLLQEREEQQLHRQERDRKFLE 1489

Query: 134  --QKLKREESVRIKKEAE-------------EAELQKM----KAIQREKSNKLEEKKRLQ 174
              Q+L+R+E  R  +E E             E +L +     K +Q E+  + +E+ + +
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549

Query: 175  ENLRREAFREHQQYKTAEFLSKLNTESPDRS-ACQSAVCGPQSSTWKLPILPRDHSWARS 233
               R   FRE +Q +      +L+ +  DR    +      Q    K      D    R 
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK---FMEDEQQLRR 1606

Query: 234  WAYRDSLKAEENRKLQKMKDEQ-HQKSELLELKRQQQEQE 272
               +  L+ E +RK +  +DEQ  Q+ E  +L RQ+++++
Sbjct: 1607 QEGQQQLRQERDRKFR--EDEQLLQEREEQQLHRQERDRK 1644


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 53/203 (26%), Positives = 102/203 (50%), Gaps = 16/203 (7%)

Query: 80  IQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           ++R  EQE+A L + +E+   +      RRL   + E E R+KQ+  L + +       E
Sbjct: 788 LRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-------E 839

Query: 140 ESVRIKKEAEEAE--LQKMKAIQREKSNKL----EEKKRLQENLRREAFREHQQYKTAEF 193
           E+ +  +E EEA+  L++ +    E++ +L    EE+KR +  ++R+     Q+ +  E 
Sbjct: 840 EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 899

Query: 194 LSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKD 253
           L +L  +   +   Q  +  P SSTW             + +  +  K EE R+ Q  ++
Sbjct: 900 LRRLQQQQQQQQLAQMKL--PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 957

Query: 254 EQHQKSELLELKRQQQEQERAKI 276
           ++ Q+ EL++  +QQQ+Q++ K+
Sbjct: 958 QRRQQRELMKALQQQQQQQQQKL 980



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 49/200 (24%), Positives = 95/200 (47%), Gaps = 7/200 (3%)

Query: 84  AEQELANLEKWK----EQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           A ++L  LEK K    EQ R +      R     + + E+R++Q+  L + + +++ +RE
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 775

Query: 140 ESVRIKKEAEEA-ELQKMKAIQREKSNKLEEKKRLQENLRR--EAFREHQQYKTAEFLSK 196
           E    +++ EEA   Q+ + I   +  + EE+++ +E LRR  E  RE ++ +  E L +
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 835

Query: 197 LNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQH 256
              E   + A +      +    +L +             R   + E  R+ + M+  Q 
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895

Query: 257 QKSELLELKRQQQEQERAKI 276
           Q+  L  L++QQQ+Q+ A++
Sbjct: 896 QQEALRRLQQQQQQQQLAQM 915



 Score = 28.9 bits (63), Expect = 8.8
 Identities = 50/203 (24%), Positives = 81/203 (39%), Gaps = 18/203 (8%)

Query: 100 AKPVH---LVPRRLGGSQSETEVRQKQQLQ----LMQSKYKQKLKREESVRIKKEAEEAE 152
           A P H   L   RL   Q  T + Q Q LQ    L+Q +Y Q L +++     K A  ++
Sbjct: 591 APPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQ-----KAALSSQ 645

Query: 153 LQKMKAIQREKSNKLEEKKRLQE-NLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAV 211
            Q+  A+  ++   L  K R+ + N+     R      T        T S        +V
Sbjct: 646 QQQQLALLLQQFQTL--KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSV 703

Query: 212 CG-PQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQE 270
              P  +T   P L +     ++ A +   +  E     K ++E+ ++ E  EL+RQQ+E
Sbjct: 704 WDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--ELRRQQEE 761

Query: 271 QERAKIHQTEHRRVNNAFLDRLQ 293
             R +  +   RR       R Q
Sbjct: 762 ILRRQQEEERKRREEEELARRKQ 784


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
          Length = 1320

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 53/203 (26%), Positives = 102/203 (50%), Gaps = 16/203 (7%)

Query: 80   IQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
            ++R  EQE+A L + +E+   +      RRL   + E E R+KQ+  L + +       E
Sbjct: 815  LRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-------E 866

Query: 140  ESVRIKKEAEEAE--LQKMKAIQREKSNKL----EEKKRLQENLRREAFREHQQYKTAEF 193
            E+ +  +E EEA+  L++ +    E++ +L    EE+KR +  ++R+     Q+ +  E 
Sbjct: 867  EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 926

Query: 194  LSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKD 253
            L +L  +   +   Q  +  P SSTW             + +  +  K EE R+ Q  ++
Sbjct: 927  LRRLQQQQQQQQLAQMKL--PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 984

Query: 254  EQHQKSELLELKRQQQEQERAKI 276
            ++ Q+ EL++  +QQQ+Q++ K+
Sbjct: 985  QRRQQRELMKALQQQQQQQQQKL 1007



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 49/200 (24%), Positives = 95/200 (47%), Gaps = 7/200 (3%)

Query: 84  AEQELANLEKWK----EQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           A ++L  LEK K    EQ R +      R     + + E+R++Q+  L + + +++ +RE
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 802

Query: 140 ESVRIKKEAEEA-ELQKMKAIQREKSNKLEEKKRLQENLRR--EAFREHQQYKTAEFLSK 196
           E    +++ EEA   Q+ + I   +  + EE+++ +E LRR  E  RE ++ +  E L +
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 862

Query: 197 LNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQH 256
              E   + A +      +    +L +             R   + E  R+ + M+  Q 
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922

Query: 257 QKSELLELKRQQQEQERAKI 276
           Q+  L  L++QQQ+Q+ A++
Sbjct: 923 QQEALRRLQQQQQQQQLAQM 942



 Score = 28.9 bits (63), Expect = 8.8
 Identities = 50/203 (24%), Positives = 81/203 (39%), Gaps = 18/203 (8%)

Query: 100 AKPVH---LVPRRLGGSQSETEVRQKQQLQ----LMQSKYKQKLKREESVRIKKEAEEAE 152
           A P H   L   RL   Q  T + Q Q LQ    L+Q +Y Q L +++     K A  ++
Sbjct: 618 APPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQ-----KAALSSQ 672

Query: 153 LQKMKAIQREKSNKLEEKKRLQE-NLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAV 211
            Q+  A+  ++   L  K R+ + N+     R      T        T S        +V
Sbjct: 673 QQQQLALLLQQFQTL--KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSV 730

Query: 212 CG-PQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQE 270
              P  +T   P L +     ++ A +   +  E     K ++E+ ++ E  EL+RQQ+E
Sbjct: 731 WDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--ELRRQQEE 788

Query: 271 QERAKIHQTEHRRVNNAFLDRLQ 293
             R +  +   RR       R Q
Sbjct: 789 ILRRQQEEERKRREEEELARRKQ 811


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 53/203 (26%), Positives = 102/203 (50%), Gaps = 16/203 (7%)

Query: 80  IQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           ++R  EQE+A L + +E+   +      RRL   + E E R+KQ+  L + +       E
Sbjct: 794 LRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-------E 845

Query: 140 ESVRIKKEAEEAE--LQKMKAIQREKSNKL----EEKKRLQENLRREAFREHQQYKTAEF 193
           E+ +  +E EEA+  L++ +    E++ +L    EE+KR +  ++R+     Q+ +  E 
Sbjct: 846 EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 905

Query: 194 LSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKD 253
           L +L  +   +   Q  +  P SSTW             + +  +  K EE R+ Q  ++
Sbjct: 906 LRRLQQQQQQQQLAQMKL--PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 963

Query: 254 EQHQKSELLELKRQQQEQERAKI 276
           ++ Q+ EL++  +QQQ+Q++ K+
Sbjct: 964 QRRQQRELMKALQQQQQQQQQKL 986



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 49/200 (24%), Positives = 95/200 (47%), Gaps = 7/200 (3%)

Query: 84  AEQELANLEKWK----EQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           A ++L  LEK K    EQ R +      R     + + E+R++Q+  L + + +++ +RE
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781

Query: 140 ESVRIKKEAEEA-ELQKMKAIQREKSNKLEEKKRLQENLRR--EAFREHQQYKTAEFLSK 196
           E    +++ EEA   Q+ + I   +  + EE+++ +E LRR  E  RE ++ +  E L +
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841

Query: 197 LNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQH 256
              E   + A +      +    +L +             R   + E  R+ + M+  Q 
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 257 QKSELLELKRQQQEQERAKI 276
           Q+  L  L++QQQ+Q+ A++
Sbjct: 902 QQEALRRLQQQQQQQQLAQM 921



 Score = 28.9 bits (63), Expect = 8.8
 Identities = 50/203 (24%), Positives = 81/203 (39%), Gaps = 18/203 (8%)

Query: 100 AKPVH---LVPRRLGGSQSETEVRQKQQLQ----LMQSKYKQKLKREESVRIKKEAEEAE 152
           A P H   L   RL   Q  T + Q Q LQ    L+Q +Y Q L +++     K A  ++
Sbjct: 597 APPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQ-----KAALSSQ 651

Query: 153 LQKMKAIQREKSNKLEEKKRLQE-NLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAV 211
            Q+  A+  ++   L  K R+ + N+     R      T        T S        +V
Sbjct: 652 QQQQLALLLQQFQTL--KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSV 709

Query: 212 CG-PQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQE 270
              P  +T   P L +     ++ A +   +  E     K ++E+ ++ E  EL+RQQ+E
Sbjct: 710 WDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--ELRRQQEE 767

Query: 271 QERAKIHQTEHRRVNNAFLDRLQ 293
             R +  +   RR       R Q
Sbjct: 768 ILRRQQEEERKRREEEELARRKQ 790


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 53/203 (26%), Positives = 102/203 (50%), Gaps = 16/203 (7%)

Query: 80  IQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           ++R  EQE+A L + +E+   +      RRL   + E E R+KQ+  L + +       E
Sbjct: 794 LRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQE-------E 845

Query: 140 ESVRIKKEAEEAE--LQKMKAIQREKSNKL----EEKKRLQENLRREAFREHQQYKTAEF 193
           E+ +  +E EEA+  L++ +    E++ +L    EE+KR +  ++R+     Q+ +  E 
Sbjct: 846 EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 905

Query: 194 LSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKD 253
           L +L  +   +   Q  +  P SSTW             + +  +  K EE R+ Q  ++
Sbjct: 906 LRRLQQQQQQQQLAQMKL--PSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 963

Query: 254 EQHQKSELLELKRQQQEQERAKI 276
           ++ Q+ EL++  +QQQ+Q++ K+
Sbjct: 964 QRRQQRELMKALQQQQQQQQQKL 986



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 49/200 (24%), Positives = 95/200 (47%), Gaps = 7/200 (3%)

Query: 84  AEQELANLEKWK----EQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           A ++L  LEK K    EQ R +      R     + + E+R++Q+  L + + +++ +RE
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781

Query: 140 ESVRIKKEAEEA-ELQKMKAIQREKSNKLEEKKRLQENLRR--EAFREHQQYKTAEFLSK 196
           E    +++ EEA   Q+ + I   +  + EE+++ +E LRR  E  RE ++ +  E L +
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841

Query: 197 LNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQH 256
              E   + A +      +    +L +             R   + E  R+ + M+  Q 
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 257 QKSELLELKRQQQEQERAKI 276
           Q+  L  L++QQQ+Q+ A++
Sbjct: 902 QQEALRRLQQQQQQQQLAQM 921



 Score = 28.9 bits (63), Expect = 8.8
 Identities = 50/203 (24%), Positives = 81/203 (39%), Gaps = 18/203 (8%)

Query: 100 AKPVH---LVPRRLGGSQSETEVRQKQQLQ----LMQSKYKQKLKREESVRIKKEAEEAE 152
           A P H   L   RL   Q  T + Q Q LQ    L+Q +Y Q L +++     K A  ++
Sbjct: 597 APPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQ-----KAALSSQ 651

Query: 153 LQKMKAIQREKSNKLEEKKRLQE-NLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAV 211
            Q+  A+  ++   L  K R+ + N+     R      T        T S        +V
Sbjct: 652 QQQQLALLLQQFQTL--KMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSV 709

Query: 212 CG-PQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQE 270
              P  +T   P L +     ++ A +   +  E     K ++E+ ++ E  EL+RQQ+E
Sbjct: 710 WDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--ELRRQQEE 767

Query: 271 QERAKIHQTEHRRVNNAFLDRLQ 293
             R +  +   RR       R Q
Sbjct: 768 ILRRQQEEERKRREEEELARRKQ 790


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 61/239 (25%), Positives = 95/239 (39%), Gaps = 27/239 (11%)

Query: 10  SGLGASPASRPTRDPQDPSGRQGELSPVEDQREGL----EAAPKGPSRESVVHAGQRRTS 65
           S   ASPA  P   P  P+  Q E  P E   +        AP  P   S   AG     
Sbjct: 539 SAAPASPAPSPAPSPT-PAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDRE 597

Query: 66  AYTLIAPNINRRNEIQRIAEQELANLE-----KWKEQNRAKPVHLVPRRLGGSQ--SETE 118
             T +     R+   QR  E++   L+     + +E+  A+       R   ++   E E
Sbjct: 598 EATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQE 657

Query: 119 VRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLR 178
            R+K Q +  + +  QK K E   R ++EAE   L++ K  Q+++  + E +KRL+E ++
Sbjct: 658 AREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMK 717

Query: 179 REAFREHQQYKTAEFLSKLNT--ESPD-------------RSACQSAVCGPQSSTWKLP 222
           R    E  + K  +   + N    SP+             + A Q     PQ   W LP
Sbjct: 718 RTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLP 776



 Score = 36.6 bits (83), Expect = 0.042
 Identities = 37/173 (21%), Positives = 79/173 (45%), Gaps = 18/173 (10%)

Query: 23  DPQDPSGRQGEL-SPVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNI------- 74
           +P+ PSG+ G   +P +++    EA  +GP+  ++     R     +  +P         
Sbjct: 67  EPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSP 126

Query: 75  NRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQ 134
             + E+++  E+    L K + + RAK  +L  ++    + E + +  ++ QL + +   
Sbjct: 127 PTKQEVKKAGERH--KLAKERREERAK--YLAAKKAVWLEKEEKAKALREKQLQERR--- 179

Query: 135 KLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQ 187
             +R E  R+K E   A L++ +  + EK NK   +  +Q ++++      QQ
Sbjct: 180 --RRLEEQRLKAEQRRAALEERQRQKLEK-NKERYEAAIQRSVKKTWAEIRQQ 229



 Score = 35.4 bits (80), Expect = 0.094
 Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 14/159 (8%)

Query: 161 REKSNKLEEKKRLQENLRREAFREHQQYKT-AEFLSKLNTESPDRSACQSAVCGPQSSTW 219
           RE++ +L  +KR Q   +RE  RE Q+ +  AE   ++  E   R A   A    ++   
Sbjct: 596 REEATRLLAEKRRQAREQRE--REEQERRLQAERDKRMREEQLAREAEARAEREAEARR- 652

Query: 220 KLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQT 279
                 R+   AR  A  +    EE  +LQK K+E   +S   E +RQ+ E+E+    Q 
Sbjct: 653 ------REEQEAREKAQAEQ---EEQERLQKQKEEAEARSRE-EAERQRLEREKHFQQQE 702

Query: 280 EHRRVNNAFLDRLQGKSQPGGLEQSGGCWNMNSGNSWGS 318
           + R+     L+ +  +++   + ++    +    N+ GS
Sbjct: 703 QERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGS 741


>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
          Length = 1233

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 60/215 (27%), Positives = 95/215 (44%), Gaps = 26/215 (12%)

Query: 79  EIQRIAEQELANLEK--WKEQNRAKPVHLVPRRLGGSQSETEV----RQKQQLQLMQSKY 132
           E +R+ EQ L  LE+  W+E  R +   L+     G +   E     R++QQ  L    +
Sbjct: 244 EKRRLEEQRLQALERRLWEENRRQE---LLEEEGEGQEPPLEAERAPREEQQRSLEAPGW 300

Query: 133 KQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAE 192
           +   +RE   R + EAEE   +     Q E+  +LEE  RL+E  R    +E ++ + AE
Sbjct: 301 EDAERREREERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRR----QEEEEGRCAE 356

Query: 193 FLSKLNTES----PDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKL 248
            L +   E      +    ++ V GP       P    +    R  A  + L  EE    
Sbjct: 357 ELKRQEEEEAEGWEELEQQEAEVQGP-------PEALEETGEGRRGAEEEDLGEEEEEGQ 409

Query: 249 QKMKDEQHQKSELL-ELKRQQQEQERAKIH-QTEH 281
             ++D + Q SELL + + + ++QER K   Q EH
Sbjct: 410 AHLEDWRGQLSELLNDFEERLEDQERLKPEGQREH 444



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 45/189 (23%), Positives = 71/189 (37%), Gaps = 28/189 (14%)

Query: 11  GLGASPASRPTRDPQDPSGRQGELSPVED-------QREGLEAAPKGPSRESVVHAGQRR 63
           G G  P     R P++   R  E    ED       +RE LEA  +    ++   A +RR
Sbjct: 274 GEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERR 333

Query: 64  TSAYTLIAPNINRRNE-----IQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETE 118
                       R+ E      + +  QE    E W+E                 Q E E
Sbjct: 334 RLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELE---------------QQEAE 378

Query: 119 VRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLR 178
           V+   +  L ++   ++   EE +  ++E  +A L+  +    E  N  EE+   QE L+
Sbjct: 379 VQGPPEA-LEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFEERLEDQERLK 437

Query: 179 REAFREHQQ 187
            E  REH +
Sbjct: 438 PEGQREHSE 446



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 47/201 (23%), Positives = 76/201 (37%), Gaps = 41/201 (20%)

Query: 17   ASRPTRDPQDPSGRQGELSPVEDQREGLEAAP---KGPSRESVVHAGQRRTSAYTLIAPN 73
            A RP  +P +PS    E S   D+R      P   KG  R+    A +R+ ++  L A  
Sbjct: 993  AGRPDPEPSEPSKEDQESS---DRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQ 1049

Query: 74   INRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK 133
              + ++      +E             KP+      L GS+   +V   Q L +  +  K
Sbjct: 1050 QEKPSQTPEAGRKE-------------KPMLQSRHSLDGSKLTEKVETAQPLWITLALQK 1096

Query: 134  QKLKREESVRIKKEAEEAELQKMKAIQRE--------------------KSNKLEEKKRL 173
            QK  RE+    ++  +  E ++ + + +E                    KS  L E+KR 
Sbjct: 1097 QKGFREQQATREERKQAREAKQAEKLSKENVSVSVQPGSSSVSRAGSLHKSTALPEEKRP 1156

Query: 174  QENLRREAFREHQQYKTAEFL 194
            +  + R   RE  Q K A  L
Sbjct: 1157 ETAVSRLERRE--QLKKANTL 1175


>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
          Length = 749

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 33/118 (27%), Positives = 61/118 (51%), Gaps = 7/118 (5%)

Query: 76  RRNEI-QRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQ 134
           +R E+ QR+AE+     E+   +  A+       +L     E  +R++++ +  Q +   
Sbjct: 511 KREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQ--- 567

Query: 135 KLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAE 192
              +EE  R+++EAE    ++ K  QRE+  +LE KKRL+E ++R    E    KT++
Sbjct: 568 ---KEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSD 622



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 34/145 (23%), Positives = 58/145 (40%), Gaps = 22/145 (15%)

Query: 139 EESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLN 198
           EE+ R+        L + + + RE+  K E ++R QE L R+   E  Q    E  ++  
Sbjct: 477 EEATRL--------LAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE 528

Query: 199 TESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQK 258
            ES    A Q+                ++    R    R   + EE  + Q+ K+E+ + 
Sbjct: 529 EESRRLEAEQAR--------------EKEEQLQRQAEERALREREEAERAQRQKEEEARV 574

Query: 259 SELLELKRQQQEQERAKIHQTEHRR 283
            E  E  RQ++E+   +  Q    R
Sbjct: 575 REEAERVRQEREKHFQREEQERLER 599



 Score = 32.7 bits (73), Expect = 0.61
 Identities = 36/180 (20%), Positives = 73/180 (40%), Gaps = 25/180 (13%)

Query: 127 LMQSKYKQKLKREESVRIKKEAEEAELQKMKAI-----QREKSNKLEEKKRLQENLRREA 181
           L + +   + +RE+  R ++E EE E QK + +     +   + + EE +RL+    RE 
Sbjct: 483 LAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQARE- 541

Query: 182 FREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLK 241
            +E Q  + AE  +    E  +R+  Q                      AR     + ++
Sbjct: 542 -KEEQLQRQAEERALREREEAERAQRQK------------------EEEARVREEAERVR 582

Query: 242 AEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQPGGL 301
            E  +  Q+ + E+ ++ + LE   ++  +  A   +T  +R  +     L G ++   L
Sbjct: 583 QEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSAL 642


>gi|41152097 DNA segment on chromosome X and Y (unique) 155
           expressed sequence isoform 1 [Homo sapiens]
          Length = 695

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 40/176 (22%), Positives = 92/176 (52%), Gaps = 5/176 (2%)

Query: 121 QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRRE 180
           ++Q+LQ ++ + +++ +RE+    ++ AEE + ++++ ++RE+  K EEK R +E  +R+
Sbjct: 274 ERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERER--KREEKLRKREQKQRD 331

Query: 181 AFREHQQYKTAEFLSKLNTESPDRSACQS-AVCGPQSSTWKLPILPRDHSWARSWAYRDS 239
                 Q K  +  ++   +  ++   +   +   Q +   + ++    S A++   R+ 
Sbjct: 332 RELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQ 391

Query: 240 LKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGK 295
            + EE  +LQ  + E+ ++ +  EL+R ++E+ERA   Q + R +    L  L  K
Sbjct: 392 EQKEEKLRLQ--QQEERRRLQEAELRRVEEEKERALGLQRKERELRERLLSILLSK 445



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 38/206 (18%)

Query: 119 VRQKQQLQLMQSKYKQKLKREESVRIK------KEAEEAELQKMKAIQREKSNKLEEKKR 172
           ++    L+ M+  YK +  +  +  IK      K   +A ++K + ++R+K  +LE+++ 
Sbjct: 228 IQAMSALRGMKLMYKGEDGKAVACNIKVSFDSTKHLSDASIKK-RQLERQKLQELEQQR- 285

Query: 173 LQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWAR 232
            +E  RRE  +E ++ + AE   +   E  +R   +      +    K     RD    R
Sbjct: 286 -EEQKRRE--KEAEERQRAEERKQKELEELERERKR------EEKLRKREQKQRDRELRR 336

Query: 233 SWAYRDSLKAEENRKLQ-KMKDEQHQ-------------------KSELLELKRQQQEQE 272
           +    + L+AEE ++LQ K+K E+ +                   +++ ++L+ Q+Q++E
Sbjct: 337 NQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEE 396

Query: 273 RAKI-HQTEHRRVNNAFLDRLQGKSQ 297
           + ++  Q E RR+  A L R++ + +
Sbjct: 397 KLRLQQQEERRRLQEAELRRVEEEKE 422


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 49/208 (23%), Positives = 95/208 (45%), Gaps = 23/208 (11%)

Query: 81  QRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREE 140
           ++I EQE    EK +EQ          RR      E E + ++Q ++M  K ++K++R+E
Sbjct: 321 EKIREQE----EKIREQEEKM------RRQEEMMWEKEEKMRRQEEMMWEK-EEKMRRQE 369

Query: 141 SVRIKKEAEEAELQKMKAIQREKSNKLEEKK------RLQENLRREAFREHQQYKTAEFL 194
            +  +KE +    ++M   + EK  +LEEK       R QE  R+E  +  +Q K  E  
Sbjct: 370 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 429

Query: 195 SKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDE 254
           +K+  +       +  +   +   W+     ++         R+  K +E  ++ + +++
Sbjct: 430 AKMWRQEEKIREQEEKIREQEKKMWR-----QEEKIHEQEKIREEEKRQEQEEMWRQEEK 484

Query: 255 QHQKSELLELKRQQQEQERAKIHQTEHR 282
            H++ E+   K +  EQE  KI + E +
Sbjct: 485 IHEQEEIWRQKEKMHEQEE-KIRKQEEK 511



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 54/260 (20%), Positives = 107/260 (41%), Gaps = 21/260 (8%)

Query: 37  VEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKE 96
           + +Q +  E   K    E +    +R+     +       R + ++I EQE    + W++
Sbjct: 400 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK---KMWRQ 456

Query: 97  QNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLK-REESVRIKKEAEEAELQK 155
           + +      +       + E   RQ++++   +  ++QK K  E+  +I+K+ E+   Q+
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQE 516

Query: 156 MKAI--------QREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSAC 207
            K          Q EK  + EEK R QE + RE  + H+Q K  E   +   E  D+   
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWE--EEKRQEQEDKMWR 574

Query: 208 Q-SAVCGPQSSTWKLPILPRDHSWARS------WAYRDSLKAEENRKLQKMKDEQHQKSE 260
           Q   +   +   W+     R+    R       W   + ++ +E +  ++ +  + Q+ +
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634

Query: 261 LLELKRQQQEQERAKIHQTE 280
           + E +   QEQE     Q E
Sbjct: 635 IREQEEMTQEQEEKMGEQEE 654



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 47/208 (22%), Positives = 91/208 (43%), Gaps = 22/208 (10%)

Query: 81  QRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEV-RQKQQLQLMQSKYKQKLKRE 139
           ++I EQE    E W+E+ +      +       + E ++ RQ+++++  + K     ++E
Sbjct: 538 EKIREQE----EMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV---WRQE 590

Query: 140 ESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFRE--HQQYKTAEFLSKL 197
           E +R ++E  + + +KM   Q EK  + EEK + QE   RE   +   Q+  T E   K+
Sbjct: 591 EKIREQEEKRQEQEEKMWK-QEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKM 649

Query: 198 NTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQ 257
             +       +  +   + + W      R     R    +   + E+ R+ ++M  EQ +
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMW------RQEEKIREQEKKIREQEEKIREQEEMMQEQEE 703

Query: 258 K-----SELLELKRQQQEQERAKIHQTE 280
           K      ++ E + + QEQE     Q E
Sbjct: 704 KMWEQEEKMCEQEEKMQEQEEKMRRQEE 731



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 50/232 (21%), Positives = 110/232 (47%), Gaps = 39/232 (16%)

Query: 75  NRRNEIQRIAEQELANLEKWK-----EQNRAKPVHL------VPRRLGGSQSETEVRQKQ 123
           + ++EIQ   ++    LE+ K     +Q +A+  HL      V  +L     E E+  + 
Sbjct: 235 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR- 293

Query: 124 QLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFR 183
              L Q + ++  ++EE ++  +E  + + +K++  Q EK  + EEK R QE +  E  +
Sbjct: 294 ---LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE-QEEKIREQEEKMRRQEEMMWE--K 347

Query: 184 EHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAE 243
           E +  +  E +     E  ++   Q      +   W+     ++    R    ++ +  E
Sbjct: 348 EEKMRRQEEMM----WEKEEKMRRQ------EEMMWE-----KEEKMRR----QEEMMWE 388

Query: 244 ENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGK 295
           +  K+++++++ H++ ++ E + ++QE+E  KI + E R+   A + R + K
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEEE--KIREQEKRQEQEAKMWRQEEK 438



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 39/198 (19%), Positives = 90/198 (45%), Gaps = 34/198 (17%)

Query: 81  QRIAEQELANLEK-WKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           ++I EQE    EK W+++ + +      +       + E + ++Q + +Q + ++  ++E
Sbjct: 577 EKIREQE----EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE 632

Query: 140 ESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENL--RREAFREHQQYKTAEFLSKL 197
           E +R ++E  + + +KM   Q EK  + EEK + QE    R+E     Q+ K  E   K+
Sbjct: 633 EKIREQEEMTQEQEEKM-GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI 691

Query: 198 NTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQ 257
             +       +  +   +   W+                ++    E+  K+Q+ +++  +
Sbjct: 692 REQ-------EEMMQEQEEKMWE----------------QEEKMCEQEEKMQEQEEKMRR 728

Query: 258 KSELL---ELKRQQQEQE 272
           + E +   E++ +QQE++
Sbjct: 729 QEEKMWEQEVRLRQQEEK 746



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 24/168 (14%), Positives = 73/168 (43%), Gaps = 4/168 (2%)

Query: 117 TEVRQKQQLQLMQSKYKQKLKREESVRIKKEAE--EAELQKMKAIQREKSNKLEEKKRLQ 174
           T+ R    L+L ++    +  +E++ +++++ +  E+E  +++   +E   KLE  K L 
Sbjct: 199 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 258

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSW 234
              + +A  +H   +     +KL  +  +           +   W+     +   W    
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE--EKIQEWEEKI 316

Query: 235 AYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHR 282
             ++    E+  K+++ +++  ++ E++  K ++  ++   + + E +
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 53/224 (23%), Positives = 102/224 (45%), Gaps = 19/224 (8%)

Query: 80  IQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           +++ +E+++A L+K  E+  A+    + ++L   + E + + K  L+  QS+Y  K+ +E
Sbjct: 470 MKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEY-LKISQE 528

Query: 140 ESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNT 199
           +  +     EE ELQK KAI  E  NKL + ++  E  R          + +  L +   
Sbjct: 529 KEQQESLALEELELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKS--LQENKN 585

Query: 200 ESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEEN----RKLQKMKDEQ 255
           +S D +    A     +   ++ ++   H         +SLK +++     KLQ +K + 
Sbjct: 586 QSKDLAVHLEAEKNKHNK--EITVMVEKHK-----TELESLKHQQDALWTEKLQVLKQQY 638

Query: 256 HQKSELLELKRQQQEQERAK----IHQTEHRRVNNAFLDRLQGK 295
             + E L  K +Q+++   K    I Q     +N   L++L  K
Sbjct: 639 QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK 682



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 65/286 (22%), Positives = 129/286 (45%), Gaps = 39/286 (13%)

Query: 31   QGELSPVEDQREGLEAAPKGPSR---ESVVHAGQRRTSAYTL--IAPNINRRNEIQ-RIA 84
            + + S +E +   LE   K  +    E   H  Q+     +L  +  N N++ +I+ +  
Sbjct: 1503 EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562

Query: 85   EQELANLEKWKEQ--NRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESV 142
             Q+L + ++  E+  NR K              E  +  + Q+  M+++ + K K  E V
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAE-----------EKILTLENQVYSMKAELETKKKELEHV 1611

Query: 143  RIKKEAEEAELQKMK-AIQREKSNKLEEKKR--------LQENLRREAFREHQQYK--TA 191
             +  +++E EL+ ++  ++ E + KL E KR        +++ L  +   + +QYK  T 
Sbjct: 1612 NLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE 1671

Query: 192  EFLSKLNTESPDRS----ACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRK 247
              LS+LNT+  +R       +  +   +SS  +  I+PR  S     AY +  +A+    
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR--SAKNVAAYTEQEEADSQGC 1729

Query: 248  LQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQ 293
            +QK  +E   K  +L+    ++E+   ++ Q +   V++ F  R Q
Sbjct: 1730 VQKTYEE---KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 45/215 (20%), Positives = 94/215 (43%), Gaps = 28/215 (13%)

Query: 82  RIAEQELA---NLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKR 138
           RI E E +   +L++ K Q++   VHL   +   ++  T + +K + +L   K++Q    
Sbjct: 568 RILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALW 627

Query: 139 EESVRIKKEAEEAELQKMKA-IQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKL 197
            E +++ K+  + E++K++   ++EK   L++K+ +        F+ H +    + L KL
Sbjct: 628 TEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII--------FQAHIEEMNEKTLEKL 679

Query: 198 NTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQ 257
           + +  +  +  S +     +  KL                + L   +++   KMK E   
Sbjct: 680 DVKQTELESLSSELSEVLKARHKL---------------EEELSVLKDQT-DKMKQELEA 723

Query: 258 KSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRL 292
           K +  +   QQQ     K H+   +R   A  D++
Sbjct: 724 KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQI 758



 Score = 36.6 bits (83), Expect = 0.042
 Identities = 45/219 (20%), Positives = 102/219 (46%), Gaps = 31/219 (14%)

Query: 68   TLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGG---SQSETEVRQKQQ 124
            TL    +++  ++++  E     L + ++Q  AK + +      G   + S  E  QK+Q
Sbjct: 969  TLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQ 1028

Query: 125  LQLMQSKYKQKLKREESVRIKKEAEEA-ELQKMKAIQ-REKSNKLEEKKRL-------QE 175
            ++ +   ++++L    S+  KK  ++A ELQ++  IQ +EK  ++ E K+        +E
Sbjct: 1029 IESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKE 1088

Query: 176  NLRRE-AFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSW 234
             + +E  + + +  K    L++L  +   +SA  +++   ++               +  
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET---------------KLK 1133

Query: 235  AYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQER 273
            A+ + L+ + N+ L   K+    + +L+ELK   +E +R
Sbjct: 1134 AHLEKLEVDLNKSL---KENTFLQEQLVELKMLAEEDKR 1169



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 50/262 (19%), Positives = 107/262 (40%), Gaps = 53/262 (20%)

Query: 34   LSPVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEK 93
            LS +E Q   LE    G  RE      Q+       +  ++     +++  +QEL  L+K
Sbjct: 1918 LSNMEAQHNDLEFKLAGAEREK-----QKLGKEIVRLQKDLRM---LRKEHQQELEILKK 1969

Query: 94   WKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREES---VRIKK---E 147
              +Q R +       ++   Q + E++    L+ +  ++  +L ++E    + IK+   +
Sbjct: 1970 EYDQEREE-------KIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022

Query: 148  AEEAELQKMKAIQREKSNKLEEKKRLQENLRREA--FREHQQYKTAEFLSKLNTESPDRS 205
            A+E E + +++ Q E +  L++     ++L+R A  + E    +  E  +K+        
Sbjct: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082

Query: 206  ACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENR-----KLQKMKDEQHQKSE 260
              Q                           Y+  L+ EEN       + +++ +  QK+ 
Sbjct: 2083 ELQK-------------------------KYQQKLEQEENPGNDNVTIMELQTQLAQKTT 2117

Query: 261  LLELKRQQQEQERAKIHQTEHR 282
            L+   + ++++ R +IH  E R
Sbjct: 2118 LISDSKLKEQEFREQIHNLEDR 2139



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 52/235 (22%), Positives = 102/235 (43%), Gaps = 38/235 (16%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQL-MQSKYKQK 135
           R+ I+++  Q    L + KE++       + + L  +Q   E R+K + ++  Q K  +K
Sbjct: 388 RSRIKQMTTQG-EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK 446

Query: 136 LKREESVRI---------------KKEAEE--AELQKM--KAIQREKSNKLEEKKRLQEN 176
              EE + +               KK +EE  A+LQK+  K + R K  +L +K + +E 
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR-KEQELTKKLQTRER 505

Query: 177 LRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWAR---- 232
             +E  +   +   +E+L K++ E       Q ++   +    K  IL    +  R    
Sbjct: 506 EFQEQMKVALEKSQSEYL-KISQEKEQ----QESLALEELELQKKAILTESENKLRDLQQ 560

Query: 233 -SWAYRD---SLKAEENRKLQKMKDEQHQKSELLELKRQQQEQE---RAKIHQTE 280
            +  YR     L++   + LQ+ K++    +  LE ++ +  +E     + H+TE
Sbjct: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 42/208 (20%), Positives = 99/208 (47%), Gaps = 16/208 (7%)

Query: 74  INRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK 133
           +N++ E +   ++E   +++W+E+ + +   +  R       E E + ++Q ++M  K +
Sbjct: 294 LNQQQEEKMWRQEE--KIQEWEEKIQEQEEKI--REQEEKIREQEEKMRRQEEMMWEK-E 348

Query: 134 QKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKK------RLQENLRREAFREHQQ 187
           +K++R+E +  +KE +   L++M   + EK  +LEEK       R QE  R+E  +  +Q
Sbjct: 349 EKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 408

Query: 188 YKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRK 247
            K  E  +K+  +       +  +   +   W+     ++         R+  K +E  +
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR-----QEEKIHEQEKIREEEKRQEQEE 463

Query: 248 LQKMKDEQHQKSELLELKRQQQEQERAK 275
           + + +++  ++ E+   K +  EQE+ +
Sbjct: 464 MWRQEEKIREQEEIWRQKEKMHEQEKIR 491



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 44/259 (16%), Positives = 104/259 (40%), Gaps = 18/259 (6%)

Query: 37  VEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKE 96
           + +Q +  E   K    E +    +R+     +       R + ++I EQE    + W++
Sbjct: 386 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK---KMWRQ 442

Query: 97  QNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKM 156
           + +      +       + E   RQ+++++  +  ++QK K  E  +I+K+ E+   Q+ 
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEE 502

Query: 157 KAIQREKSNKLEEKK--RLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGP 214
           K   +E+  + +E+K  R +E +R +  +  +Q +      ++  E  ++   Q      
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQE 562

Query: 215 QSSTWKLPILPRD-------------HSWARSWAYRDSLKAEENRKLQKMKDEQHQKSEL 261
           Q    +     R+                 + W   + ++ +E    ++ +    Q+ ++
Sbjct: 563 QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622

Query: 262 LELKRQQQEQERAKIHQTE 280
            E + + QEQE     Q E
Sbjct: 623 CEQEEKMQEQEEKMRRQEE 641



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 39/215 (18%), Positives = 102/215 (47%), Gaps = 30/215 (13%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSK-YKQK 135
           + E  R  E+++   EK +EQ   +            Q E ++R++++ Q  ++K ++Q+
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEEKR------------QEEEKIREQEKRQEQEAKMWRQE 422

Query: 136 LK-REESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFL 194
            K RE+  +I+++ ++   Q+ K  ++EK  + EEK++ QE + R+  +  +Q +     
Sbjct: 423 EKIREQEEKIREQEKKMWRQEEKIHEQEKIRE-EEKRQEQEEMWRQEEKIREQEEIWRQK 481

Query: 195 SKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWA------RSWAYRDSLKAEENRKL 248
            K++ +   R          +   W+      D          + W   + ++ E+  K+
Sbjct: 482 EKMHEQEKIRKQ--------EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIR-EQEEKI 532

Query: 249 QKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
           ++ +++  ++ E+++ + ++  ++  K+ + E  R
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/208 (22%), Positives = 90/208 (43%), Gaps = 12/208 (5%)

Query: 76  RRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQK 135
           R+ E  R  E+     EK  EQ + +       R      + E + ++Q + M  + ++ 
Sbjct: 466 RQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKI 525

Query: 136 LKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRR--EAFREHQQYKTAEF 193
            ++EE +R ++E +  E ++M   Q EK  + EEK + QE +RR  E  RE Q+ K  E 
Sbjct: 526 REQEEKIR-EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIRE-QEEKIREQ 583

Query: 194 LSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKD 253
             K+  E  ++   Q      Q    +           + W   + +  +E +  ++ + 
Sbjct: 584 KEKIR-EQEEKIWEQEEKIREQEEMMQ-------EQEEKMWEQEEKMCEQEEKMQEQEEK 635

Query: 254 EQHQKSELLELKRQQQEQERAKIHQTEH 281
            + Q+ ++ E + + ++QE       EH
Sbjct: 636 MRRQEEKMWEQEVRLRQQEEKMQEHQEH 663



 Score = 37.4 bits (85), Expect = 0.025
 Identities = 48/234 (20%), Positives = 102/234 (43%), Gaps = 57/234 (24%)

Query: 75  NRRNEIQRIAEQELANLEKWK-----EQNRAKPVHL------VPRRLGGSQSETEVRQKQ 123
           + ++EIQ   ++    LE+ K     +Q +A+  HL      V  +L     E E+  + 
Sbjct: 235 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR- 293

Query: 124 QLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFR 183
              L Q + ++  ++EE ++  +E  + + +K++  Q EK  + EEK R QE +  E  +
Sbjct: 294 ---LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE-QEEKIREQEEKMRRQEEMMWE--K 347

Query: 184 EHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYR--DSLK 241
           E +  +  E +                                   W +    R  + + 
Sbjct: 348 EEKMRRQEEMM-----------------------------------WEKEEKMRRLEEMM 372

Query: 242 AEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGK 295
            E+  K+++++++ H++ ++ E + ++QE+E  KI + E R+   A + R + K
Sbjct: 373 WEKEEKIRELEEKMHEQEKIREQEEKRQEEE--KIREQEKRQEQEAKMWRQEEK 424



 Score = 35.4 bits (80), Expect = 0.094
 Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 19/134 (14%)

Query: 77  RNEIQRIAEQE---LANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK 133
           R + ++I EQE       EK  EQ          RR      E E + ++Q + ++ + +
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592

Query: 134 QKLKREESVRIKKEAEEAELQKM------KAIQREKSNKLEEKKRLQE----------NL 177
           +  ++EE +R ++E  + + +KM         Q EK  + EEK R QE            
Sbjct: 593 KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652

Query: 178 RREAFREHQQYKTA 191
           + E  +EHQ++  A
Sbjct: 653 QEEKMQEHQEHLEA 666



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 24/168 (14%), Positives = 73/168 (43%), Gaps = 4/168 (2%)

Query: 117 TEVRQKQQLQLMQSKYKQKLKREESVRIKKEAE--EAELQKMKAIQREKSNKLEEKKRLQ 174
           T+ R    L+L ++    +  +E++ +++++ +  E+E  +++   +E   KLE  K L 
Sbjct: 199 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 258

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSW 234
              + +A  +H   +     +KL  +  +           +   W+     +   W    
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE--EKIQEWEEKI 316

Query: 235 AYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHR 282
             ++    E+  K+++ +++  ++ E++  K ++  ++   + + E +
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 58/236 (24%), Positives = 107/236 (45%), Gaps = 38/236 (16%)

Query: 76   RRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGS------QSETEVRQKQQLQLMQ 129
            ++ E++ I     A +E+  E+ R + +    +++  +      Q E E   +Q+LQL +
Sbjct: 909  KKQELEEICHDLEARVEE--EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966

Query: 130  SKYKQKLKREESVRIKKEAEEAELQKMKAI--------------QREKSNKLEEKKR--- 172
               + KLK+ E  +I  E +  +L K K +              + EKS  L + K    
Sbjct: 967  VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE 1026

Query: 173  -----LQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRD 227
                 L+E LRRE   E Q+ +  +   KL  +S D S  Q A    Q +  K+ +  ++
Sbjct: 1027 AMITDLEERLRRE---EKQRQELEKTRRKLEGDSTDLSD-QIAELQAQIAELKMQLAKKE 1082

Query: 228  HSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
                 + A  +   A++N  L+K+++ + Q SEL    ++  E ERA  ++ E ++
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQISEL----QEDLESERASRNKAEKQK 1134



 Score = 37.0 bits (84), Expect = 0.032
 Identities = 42/213 (19%), Positives = 97/213 (45%), Gaps = 28/213 (13%)

Query: 79   EIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEV-RQKQQLQLMQSKYKQKLK 137
            E Q  AE  L  +E  + Q  A+ + L  +     Q+ETE+  + ++L+   +  KQ+L+
Sbjct: 859  EKQLAAENRLTEMETLQSQLMAEKLQLQEQL----QAETELCAEAEELRARLTAKKQELE 914

Query: 138  R---EESVRIKKEAE-----EAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYK 189
                +   R+++E E     +AE +KM+   +E   +LEE++  ++ L+ E      + K
Sbjct: 915  EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK 974

Query: 190  TAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQ 249
              E    +  +   + A +  +   + + +   +   +               E+++ L 
Sbjct: 975  KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE---------------EKSKSLA 1019

Query: 250  KMKDEQHQKSELLELKRQQQEQERAKIHQTEHR 282
            K+K++       LE + +++E++R ++ +T  +
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 48/217 (22%), Positives = 93/217 (42%), Gaps = 37/217 (17%)

Query: 84   AEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKR----- 138
            A+QEL +        R + V+++ + L     E     + Q+Q M+ K+ Q ++      
Sbjct: 1157 AQQELRS-------KREQEVNILKKTL----EEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205

Query: 139  EESVRIKKEAEEAE----------LQKMKAIQREKSNKLEEKKRLQENLR--REAFREHQ 186
            E++ R+K   E+A+            ++K + + K +   ++K+++  L+  +  F E +
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE 1265

Query: 187  QYKT--AEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAY-RDSLKAE 243
            + +T  A+ ++KL  E  + +   S       S  K   L +D S   S       L  E
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLS------QSDSKSSKLTKDFSALESQLQDTQELLQE 1319

Query: 244  ENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTE 280
            ENR+   +  +  Q  +     R+Q E+E    H  E
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356



 Score = 32.3 bits (72), Expect = 0.80
 Identities = 48/253 (18%), Positives = 102/253 (40%), Gaps = 49/253 (19%)

Query: 78   NEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLK 137
            +E+Q   E E A+  K ++Q R          LG      +   +  L    ++ + + K
Sbjct: 1114 SELQEDLESERASRNKAEKQKRD---------LGEELEALKTELEDTLDSTAAQQELRSK 1164

Query: 138  REESVRIKKEA-------EEAELQKMKAIQ----REKSNKLEEKKRLQENLRR------- 179
            RE+ V I K+         EA++Q+M+        E + +LE+ KR++ NL +       
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN 1224

Query: 180  ---------------EAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPIL 224
                           +   EH++ K    L +L  +  +    ++ +        KL + 
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA---DKVTKLQVE 1281

Query: 225  PRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRV 284
              + +   S +  DS  ++  +    ++ +     ELL+ + +Q+     K+ Q E  + 
Sbjct: 1282 LDNVTGLLSQS--DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK- 1338

Query: 285  NNAFLDRLQGKSQ 297
             N+F ++L+ + +
Sbjct: 1339 -NSFREQLEEEEE 1350



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 36/161 (22%), Positives = 68/161 (42%), Gaps = 42/161 (26%)

Query: 30  RQGELSPVEDQRE--------GLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQ 81
           R G L+ +E++R+        G +A  +G          Q++ +A  ++  N        
Sbjct: 764 RAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNC------- 816

Query: 82  RIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREES 141
             A  +L N + W+   + KP+                     LQ+ + + +   K EE 
Sbjct: 817 -AAYLKLRNWQWWRLFTKVKPL---------------------LQVSRQEEEMMAKEEEL 854

Query: 142 VRIKKE--AEEAELQKMKAIQREKSNKLEEKKRLQENLRRE 180
           V+++++  A E  L +M+ +Q   S  + EK +LQE L+ E
Sbjct: 855 VKVREKQLAAENRLTEMETLQ---SQLMAEKLQLQEQLQAE 892


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 43/223 (19%), Positives = 102/223 (45%), Gaps = 19/223 (8%)

Query: 74  INRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK 133
           +N++ E +   ++E   +++W+E+ + +   +  R       E E + ++Q ++M  K +
Sbjct: 355 LNQQQEEKMWRQEE--KIQEWEEKIQEQEEKI--REQEEKIREQEEKMRRQEEMMWEK-E 409

Query: 134 QKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKK------RLQENLRREAFREHQQ 187
           +K++R+E +  +KE +    ++M   + EK  +LEEK       R QE  R+E  +  +Q
Sbjct: 410 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 469

Query: 188 YKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKL--------PILPRDHSWARSWAYRDS 239
            K  E  +K+  +       +  +   +   W+          I   +    +   +R  
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529

Query: 240 LKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHR 282
            K  E  ++ + K++ H++ E +  + ++  ++  K+H  E +
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEK 572



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 47/229 (20%), Positives = 101/229 (44%), Gaps = 42/229 (18%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSK-YKQK 135
           + E  R  E+++   EK +EQ   +            Q E ++R++++ Q  ++K ++Q+
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKR------------QEEEKIREQEKRQEQEAKMWRQE 483

Query: 136 LK-REESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFL 194
            K RE+  +I+++ E+   Q+ K  ++EK  + EEK++ QE + R+  +  +Q +     
Sbjct: 484 EKIREQEEKIREQEEKMWRQEEKIHEQEKIRE-EEKRQEQEEMWRQEEKIREQEEIWRQK 542

Query: 195 SKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWA------RSWAYRDSLKAEEN--- 245
            K++ +       +  +   +   W+      D          + W   + ++ +E    
Sbjct: 543 EKIHEQ-------EEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIR 595

Query: 246 ------RKLQKMKDEQHQK-----SELLELKRQQQEQERAKIHQTEHRR 283
                 R+ ++M  EQ +K      ++ E + + QEQE     Q E  R
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIR 644



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 57/268 (21%), Positives = 110/268 (41%), Gaps = 20/268 (7%)

Query: 22  RDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQ 81
           R+ ++    Q ++   E++R+  E   +   R+       R+          I  + E  
Sbjct: 441 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKM 500

Query: 82  RIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEV-RQKQQLQLMQSKYK---QKLK 137
              E+++   EK +E+ + +    + R+    + + E+ RQK+++   + K +   +K+ 
Sbjct: 501 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMW 560

Query: 138 REESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKL 197
           R+E     +E +  E ++    Q EK  + EEK R QE   RE     Q+  T E   K+
Sbjct: 561 RQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE-----QEEMTQEQEEKM 615

Query: 198 NTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQ 257
             E  ++   Q      Q    +     R     R    +   + E+ R+ ++M  EQ +
Sbjct: 616 G-EQEEKMCEQEEKMQEQEEKMR-----RQEEKIREQEKKIREQEEKIREQEEMMQEQEE 669

Query: 258 K-----SELLELKRQQQEQERAKIHQTE 280
           K      ++ E + + QEQE     Q E
Sbjct: 670 KMWEQEEKMCEQEEKMQEQEEKMRRQEE 697



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 48/232 (20%), Positives = 105/232 (45%), Gaps = 53/232 (22%)

Query: 75  NRRNEIQRIAEQELANLEKWK-----EQNRAKPVHL------VPRRLGGSQSETEVRQKQ 123
           + ++EIQ   ++    LE+ K     +Q +A+  HL      V  +L     E E+  + 
Sbjct: 296 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR- 354

Query: 124 QLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFR 183
              L Q + ++  ++EE ++  +E  + + +K++  Q EK  + EEK R QE +  E  +
Sbjct: 355 ---LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE-QEEKIREQEEKMRRQEEMMWE--K 408

Query: 184 EHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAE 243
           E +  +  E +                        W+     ++    R    ++ +  E
Sbjct: 409 EEKMRRQEEMM------------------------WE-----KEEKMRR----QEEMMWE 435

Query: 244 ENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGK 295
           +  K+++++++ H++ ++ E + ++QE+E  KI + E R+   A + R + K
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEE--KIREQEKRQEQEAKMWRQEEK 485



 Score = 36.6 bits (83), Expect = 0.042
 Identities = 36/170 (21%), Positives = 77/170 (45%), Gaps = 28/170 (16%)

Query: 114 QSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRL 173
           Q E   RQ+++++  + K +++   EE +R ++E  + + +KM   Q EK  + EEK + 
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQ---EEKIREQEEMTQEQEEKM-GEQEEKMCEQEEKMQE 631

Query: 174 QENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARS 233
           QE   R      Q+ K  E   K+  +       +  +   +   W+             
Sbjct: 632 QEEKMR-----RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE------------- 673

Query: 234 WAYRDSLKAEENRKLQKMKDEQHQKSELL--ELKRQQQEQERAKIHQTEH 281
              ++    E+  K+Q+ +++  ++ E +  +  R +Q++E+ + HQ EH
Sbjct: 674 ---QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ-EH 719



 Score = 35.4 bits (80), Expect = 0.094
 Identities = 31/131 (23%), Positives = 58/131 (44%), Gaps = 19/131 (14%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKL 136
           R + ++I EQE    E+ ++    +            Q E   RQ+++++  + K +++ 
Sbjct: 595 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ- 653

Query: 137 KREESVRIKKEAEEAELQKM------KAIQREKSNKLEEKKRLQE----------NLRRE 180
             EE +R ++E  + + +KM         Q EK  + EEK R QE            + E
Sbjct: 654 --EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711

Query: 181 AFREHQQYKTA 191
             +EHQ++  A
Sbjct: 712 KMQEHQEHLEA 722



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 40/176 (22%), Positives = 73/176 (41%), Gaps = 43/176 (24%)

Query: 109 RLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLE 168
           RL   Q E   RQ++++Q  + K +++   EE +R ++E    + +KM+  Q E   + E
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQ---EEKIREQEEKIREQEEKMRR-QEEMMWEKE 409

Query: 169 EKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDH 228
           EK R QE +  E  +E +  +  E +                                  
Sbjct: 410 EKMRRQEEMMWE--KEEKMRRQEEMM---------------------------------- 433

Query: 229 SWARSWAYRD-SLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
            W +    R+   K  E  K+++ ++E+ Q+ E +  + ++QEQE     Q E  R
Sbjct: 434 -WEKEEKIRELEEKMHEQEKIRE-QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 487



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 24/168 (14%), Positives = 73/168 (43%), Gaps = 4/168 (2%)

Query: 117 TEVRQKQQLQLMQSKYKQKLKREESVRIKKEAE--EAELQKMKAIQREKSNKLEEKKRLQ 174
           T+ R    L+L ++    +  +E++ +++++ +  E+E  +++   +E   KLE  K L 
Sbjct: 260 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSW 234
              + +A  +H   +     +KL  +  +           +   W+     +   W    
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE--EKIQEWEEKI 377

Query: 235 AYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHR 282
             ++    E+  K+++ +++  ++ E++  K ++  ++   + + E +
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 425


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 51/247 (20%), Positives = 109/247 (44%), Gaps = 29/247 (11%)

Query: 34  LSPVEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEK 93
           + P E +R+ LE   +    E +            L    + R   ++++  Q    +E+
Sbjct: 528 MDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQ 586

Query: 94  WKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAEL 153
            KE+ + +    + ++      +TE  ++++L   ++K K   K+ E V  +++ EE E 
Sbjct: 587 MKEEKKKQ----IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE-EA 641

Query: 154 QKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCG 213
           ++++ +Q+E     EE++R QE L+++   E ++ + A    +L  +       Q     
Sbjct: 642 RRLRWLQQE-----EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE---- 692

Query: 214 PQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQER 273
                       R     R    R+  + E+ R+L +   E+ ++ E L+ +R+ QE+E+
Sbjct: 693 ------------RREQERREQERREQERREQERQLAEQ--ERRREQERLQAERELQEREK 738

Query: 274 AKIHQTE 280
           A   Q E
Sbjct: 739 ALRLQKE 745



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 65/301 (21%), Positives = 123/301 (40%), Gaps = 34/301 (11%)

Query: 7   VVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSR-----ESVVHAGQ 61
           + NS     PA+     P+ PS  Q E     DQ +G    P+   R     ++V    +
Sbjct: 408 IANSTPNPKPAAS---SPETPSAGQQEAKT--DQADGPREPPQSARRKRSYKQAVSELDE 462

Query: 62  RRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQ 121
            +      + P  ++       A + +  L  +    +   + + P     S  ++ +++
Sbjct: 463 EQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKR 522

Query: 122 KQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEE---------KKR 172
              L+ M  K K++ +R E++R K+EAE+   QK   ++ +K  +LEE         +K 
Sbjct: 523 NTPLR-MDPKEKER-QRLENLRRKEEAEQLRRQK---VEEDKRRRLEEVKLKREERLRKV 577

Query: 173 LQENLRREAFREHQ----QYKTAEFLSKLNTESPDRSACQSA---VCGPQSSTWKLPILP 225
           LQ   R E  +E +    + K A+   K      +R A + A       +    +     
Sbjct: 578 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 637

Query: 226 RDHSWARSWAYRDSLKAEENRKLQKMKDEQHQK-SELLELKR--QQQEQERAKIHQTEHR 282
            + +    W  ++  +      LQK K+E+ ++  +  E KR  +Q+EQER +  + E  
Sbjct: 638 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697

Query: 283 R 283
           R
Sbjct: 698 R 698



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 35/122 (28%), Positives = 59/122 (48%), Gaps = 17/122 (13%)

Query: 74  INRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK 133
           + +  E +R+AEQ        +EQ R +       R    + E E R++Q+ QL + +  
Sbjct: 671 LRKAAEAKRLAEQ--------REQERREQERREQERREQERREQE-RREQERQLAEQE-- 719

Query: 134 QKLKREESVRIKKEAEEAELQKMKAIQREK-SNKLEEKKRL--QENLRREAFREHQQYKT 190
              +R E  R++ E E  E +K   +Q+E+   +LEEKK+   Q+ L     +E Q+ K 
Sbjct: 720 ---RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776

Query: 191 AE 192
            E
Sbjct: 777 KE 778



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 25/115 (21%), Positives = 60/115 (52%), Gaps = 5/115 (4%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKL 136
           + E +    QEL   +K +EQ R +      R     + E   +++++ +  + + +++ 
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707

Query: 137 KREESVRIKKEAEEAELQKMKA----IQREKSNKLEEKKRLQENLRREAFREHQQ 187
           +RE+  ++ ++    E ++++A     +REK+ +L +K++LQ  L  +  +E QQ
Sbjct: 708 RREQERQLAEQERRREQERLQAERELQEREKALRL-QKEQLQRELEEKKKKEEQQ 761


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 47/231 (20%), Positives = 106/231 (45%), Gaps = 40/231 (17%)

Query: 24   PQDPSGRQGELSPVE----DQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNE 79
            PQ P G QG L P +     Q+      P+GP R+ ++      T +  L +P + ++ +
Sbjct: 3792 PQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLM------TQSRVLSSPQLAQQGQ 3845

Query: 80   IQR-----IAEQELANLEKWKEQNRAKPVHLVPRRLGGS----------------QSETE 118
                     A+Q+    +  ++ + A   HL    +  S                Q + +
Sbjct: 3846 GLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQ 3905

Query: 119  VRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLR 178
            ++Q+QQLQ  Q   +Q+L++++ ++ ++  ++ + Q+++  Q+++  + +++ + Q+  +
Sbjct: 3906 LQQQQQLQQQQ---QQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQ 3962

Query: 179  REAFREHQQYKTAEFLSKLNT-ESPDRSACQSAVCGPQSSTWKLPILPRDH 228
            ++ F++ QQ +    L++  T  SP +   Q    GP      +P  P  H
Sbjct: 3963 QQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGP-----GMPAKPLQH 4008


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 51/244 (20%), Positives = 108/244 (44%), Gaps = 29/244 (11%)

Query: 37  VEDQREGLEAAPKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKE 96
           VE +R+ LE   +    E +            L    + R   ++++  Q    +E+ KE
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVL-QARERVEQMKE 593

Query: 97  QNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKM 156
           + + +    + ++      +TE  ++++L   ++K K   K+ E V  +++ EE E +++
Sbjct: 594 EKKKQ----IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE-EARRL 648

Query: 157 KAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQS 216
           + +Q+E     EE++R QE L+++   E ++ + A    +L  +       Q        
Sbjct: 649 RWLQQE-----EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE------- 696

Query: 217 STWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKI 276
                    R     R    R+  + E+ R+L +   E+ ++ E L+ +R+ QE+E+A  
Sbjct: 697 ---------RREQERREQERREQERREQERQLAEQ--ERRREQERLQAERELQEREKALR 745

Query: 277 HQTE 280
            Q E
Sbjct: 746 LQKE 749



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 63/303 (20%), Positives = 123/303 (40%), Gaps = 34/303 (11%)

Query: 7   VVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSR-----ESVVHAGQ 61
           + NS     PA+     P+ PS  Q E     DQ +G    P+   R     ++V    +
Sbjct: 408 IANSTPNPKPAAS---SPETPSAGQQEAKT--DQADGPREPPQSARRKRSYKQAVSELDE 462

Query: 62  RRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQ 121
            +      + P  ++       A + +  L  +    +   + + P     S  ++ +++
Sbjct: 463 EQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKR 522

Query: 122 KQQLQLMQ--SKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEE---------K 170
              L++    S  +++ +R E++R K+EAE+   QK   ++ +K  +LEE         +
Sbjct: 523 NTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQK---VEEDKRRRLEEVKLKREERLR 579

Query: 171 KRLQENLRREAFREHQ----QYKTAEFLSKLNTESPDRSACQSA---VCGPQSSTWKLPI 223
           K LQ   R E  +E +    + K A+   K      +R A + A       +    +   
Sbjct: 580 KVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639

Query: 224 LPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQK-SELLELKR--QQQEQERAKIHQTE 280
              + +    W  ++  +      LQK K+E+ ++  +  E KR  +Q+EQER +  + E
Sbjct: 640 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699

Query: 281 HRR 283
             R
Sbjct: 700 QER 702



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 35/122 (28%), Positives = 59/122 (48%), Gaps = 17/122 (13%)

Query: 74  INRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK 133
           + +  E +R+AEQ        +EQ R +       R    + E E R++Q+ QL + +  
Sbjct: 675 LRKAAEAKRLAEQ--------REQERREQERREQERREQERREQE-RREQERQLAEQE-- 723

Query: 134 QKLKREESVRIKKEAEEAELQKMKAIQREK-SNKLEEKKRL--QENLRREAFREHQQYKT 190
              +R E  R++ E E  E +K   +Q+E+   +LEEKK+   Q+ L     +E Q+ K 
Sbjct: 724 ---RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780

Query: 191 AE 192
            E
Sbjct: 781 KE 782



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 25/115 (21%), Positives = 60/115 (52%), Gaps = 5/115 (4%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKL 136
           + E +    QEL   +K +EQ R +      R     + E   +++++ +  + + +++ 
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711

Query: 137 KREESVRIKKEAEEAELQKMKA----IQREKSNKLEEKKRLQENLRREAFREHQQ 187
           +RE+  ++ ++    E ++++A     +REK+ +L +K++LQ  L  +  +E QQ
Sbjct: 712 RREQERQLAEQERRREQERLQAERELQEREKALRL-QKEQLQRELEEKKKKEEQQ 765


>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
          Length = 1317

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/190 (26%), Positives = 96/190 (50%), Gaps = 18/190 (9%)

Query: 116 ETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKA---IQREKSNKLEEKKR 172
           E E +Q+++L+ ++SK K   + EE    K+++++AEL++M+     QR+++  ++ + R
Sbjct: 597 EFERQQREELEKLESKRKLIEEMEE----KQKSDKAELERMQQEVETQRKETEIVQLQIR 652

Query: 173 LQE-NLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWA 231
            QE +L+R +F  H + K  + L++      +R   Q  +   +    +   L       
Sbjct: 653 KQEESLKRRSF--HIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQ 710

Query: 232 RSWAYRDSLKAE------ENRKLQKMKDEQHQKSELLELKRQQQEQERAKI--HQTEHRR 283
           R     ++ KAE      E  +LQK KDEQ+ K EL + + ++QE+E+  +  H  E  R
Sbjct: 711 RLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLR 770

Query: 284 VNNAFLDRLQ 293
                +  L+
Sbjct: 771 EKQEMIQLLR 780


>gi|81295809 pericentrin [Homo sapiens]
          Length = 3336

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 53/216 (24%), Positives = 95/216 (43%), Gaps = 35/216 (16%)

Query: 89  ANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEA 148
           ANL+K KE    +   ++  R     +  + RQ+ +L+L++   +Q  + +E V ++   
Sbjct: 267 ANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLR---EQHAREKEEVVLRCGQ 323

Query: 149 EEAELQKMKAIQREKSNKL---------EEKKRLQENLRREAFREHQ----------QYK 189
           E AEL++    + EK+ ++          EK    ENLR+E   +HQ          Q +
Sbjct: 324 EAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKE 383

Query: 190 TAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQ 249
            AE  ++L     D++  + A+   +S           H  A     R+ L++E  R L+
Sbjct: 384 LAEQRAELEKIFQDKNQAERALRNLES-----------HHQAAIEKLREDLQSEHGRCLE 432

Query: 250 --KMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
             + K ++ +K + LEL+  Q   E  K    E  R
Sbjct: 433 DLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIR 468



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 51/205 (24%), Positives = 95/205 (46%), Gaps = 24/205 (11%)

Query: 85   EQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRI 144
            +QE+  LE    Q  AKP    PR    +  + EV      +L+Q K ++KL     + I
Sbjct: 1496 QQEIQRLEGQLRQ-AAKPQPWGPRDSQQAPLDGEV------ELLQQKLREKLDEFNELAI 1548

Query: 145  KKEA-------EEAELQKMKAIQ---REKSNKLEEKKRLQENLRREAFREHQQYKTAEFL 194
            +KE+       +E E+++++ +    R+K  +L+E+   Q+N+ +   ++ +  K  + +
Sbjct: 1549 QKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQ-M 1607

Query: 195  SKLNTESPDRSACQSAVC--GPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMK 252
            S L   S  +S   +  C   P  S  + P +  + +  R+   R+S   +   +L+KMK
Sbjct: 1608 SSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT-QRALLRRESEVLDLKEQLEKMK 1666

Query: 253  DEQHQKSE---LLELKRQQQEQERA 274
             +   K+E    L LK   Q  + A
Sbjct: 1667 GDLESKNEEILHLNLKLDMQNSQTA 1691



 Score = 35.8 bits (81), Expect = 0.072
 Identities = 28/106 (26%), Positives = 55/106 (51%), Gaps = 8/106 (7%)

Query: 112  GSQSETEVRQKQQLQLMQSKYKQKLKRE--ESVRIKKEAEEAELQKMKAIQREKSNKLEE 169
            GS+ +T + +K++   +QS   Q   +E  ES+ ++ + +  ++Q++K      S+++EE
Sbjct: 1059 GSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEE 1118

Query: 170  KKRLQENLRREAFREHQQYKTAEFLSKL----NTESPDRSACQSAV 211
             +   E L++   RE +  + A  LS L    N    +R A Q A+
Sbjct: 1119 CRSELEVLQQR--RERENREGANLLSMLKADVNLSHSERGALQDAL 1162



 Score = 32.7 bits (73), Expect = 0.61
 Identities = 40/182 (21%), Positives = 90/182 (49%), Gaps = 17/182 (9%)

Query: 113  SQSETEVRQK-QQLQLMQSK---YKQKLKREESVRIKKEAEEAE-LQKMKA---IQREKS 164
            S  E E++   Q+L+  Q K    + +L+ E+   +++E++ A+ L++++A    QR +S
Sbjct: 2642 SSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQS 2701

Query: 165  NKL----EEKKRLQENLRREAFREHQQYKT--AEFLSKLNTESPDRSACQSAVCGPQSST 218
            ++L    + ++  ++NL++E   EH + +   A+  S+L+    D +A +S       + 
Sbjct: 2702 SRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEAL 2761

Query: 219  WKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQ 278
                +L    S     A         +  LQK+K+E   KS +++L+   ++ ++  +H 
Sbjct: 2762 RHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEE---KSRVVDLQAMLEKVQQQALHS 2818

Query: 279  TE 280
             +
Sbjct: 2819 QQ 2820



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 46/231 (19%), Positives = 88/231 (38%), Gaps = 33/231 (14%)

Query: 69   LIAPNINRRNE---IQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQL 125
            L+   +++R +   + +  +   A L+K KE+           R+   Q+  E  Q+Q L
Sbjct: 2766 LLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKS---------RVVDLQAMLEKVQQQAL 2816

Query: 126  QLMQSKYKQKLKREESVRIKKEAE---EAELQKMKAIQREKSNKLEEKKRLQENLRREAF 182
               Q    +  K  E++R +KE     ++ ++ +   +RE    LE ++     L+ E  
Sbjct: 2817 HSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELE 2876

Query: 183  REHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKA 242
            + H + K  E        +  R +  +A        W+         W R       L+ 
Sbjct: 2877 QSHPRLKEQEGRKAARRSAEARQSPAAA------EQWR--------KWQRDKEKLRELEL 2922

Query: 243  EENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQ 293
            +  R L K+K  Q    +L      + E   +++H    RR   +  D L+
Sbjct: 2923 QRQRDLHKIKQLQQTVRDL----ESKDEVPGSRLHLGSARRAAGSDADHLR 2969



 Score = 30.4 bits (67), Expect = 3.0
 Identities = 36/175 (20%), Positives = 77/175 (44%), Gaps = 35/175 (20%)

Query: 118 EVRQKQQLQLMQSKYKQKL------------KREESVRIKKEAEEAELQKMKAIQREKSN 165
           E   K QL L+Q++ K+++            K +   R+K + E+ +   ++  Q+E +N
Sbjct: 674 ETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNN 733

Query: 166 KLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILP 225
                K+  E +++E  R+   +K  +   +L  E+ ++          ++ + K  I+ 
Sbjct: 734 ----AKQKTELMKQEFQRKETDWKVMK--EELQREAEEKLTLMLLELREKAESEKQTII- 786

Query: 226 RDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTE 280
                      +  L+  E R+LQ       Q +++L+L+R   EQ+  ++ Q E
Sbjct: 787 ----------NKFELREAEMRQLQ-----DQQAAQILDLERSLTEQQ-GRLQQLE 825



 Score = 30.0 bits (66), Expect = 4.0
 Identities = 36/173 (20%), Positives = 70/173 (40%), Gaps = 6/173 (3%)

Query: 107  PRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNK 166
            P    G  +   V++   LQLM ++ +   +R+E        ++A LQ+ +     +   
Sbjct: 844  PTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL 903

Query: 167  LEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPR 226
            L+E+ + Q            Q    E  + L ++     A + A    + +   L  L  
Sbjct: 904  LQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAA-DLGALET 962

Query: 227  DHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQT 279
             H      +  DSL++    + Q +++E  Q  ELL    ++Q  ++  +HQT
Sbjct: 963  RHL-----SSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 38/181 (20%), Positives = 84/181 (46%), Gaps = 14/181 (7%)

Query: 92  EKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEA 151
           EK +E+ R +      R       E E + ++Q + MQ + ++  ++EE    K + +E 
Sbjct: 583 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE----KMQEQEE 638

Query: 152 ELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAV 211
           ++ + +    E+  K+ E++RL E  ++E   EH++ +  E + +   +  ++   +   
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPE--QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKT 696

Query: 212 CGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQ 271
              +  TW    +  + S           + ++ R+ ++M  EQ +K +  E K Q+QE+
Sbjct: 697 QEQEKKTWDQEKMREEESMRE--------REKKMREEEEMMREQEEKMQEQEEKMQEQEE 748

Query: 272 E 272
           E
Sbjct: 749 E 749



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 45/210 (21%), Positives = 93/210 (44%), Gaps = 16/210 (7%)

Query: 76  RRNEIQRIAEQELANLEK--WKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYK 133
           R+ E  R  E+++   E+  W+++ R        R   G   E E +  +Q + ++ + K
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERL-------REQEGKMREQEEKMWRQEKRLREQEK 328

Query: 134 QKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQ-ENLRREAFREHQQYKTAE 192
           +  ++E+ +R +KE  E E Q  +  Q EK  + EEK R Q E + R+  R  +Q K   
Sbjct: 329 ELREQEKELREQKELREQEEQMQE--QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386

Query: 193 FLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMK 252
              +   +  +R   Q      +    +     ++  W +    R+  K +E  K  + +
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMR----EQEKMWEQVEKMREEKKMQEQEKKTRDQ 442

Query: 253 DEQHQKSELLELKRQQQEQERAKIHQTEHR 282
           +E+ Q+ E +  + ++  +E   + + E +
Sbjct: 443 EEKMQEEERIREREKKMREEEETMREQEEK 472



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 41/207 (19%), Positives = 91/207 (43%), Gaps = 26/207 (12%)

Query: 81  QRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREE 140
           ++I EQE   +EK  ++   K       R   S  E E + +++ ++M+ + ++  ++EE
Sbjct: 684 EKIWEQE--KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741

Query: 141 SVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFL------ 194
               K + +E E+ + +    E+  K+ E++RL E  ++E   EH++ +  E +      
Sbjct: 742 ----KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPE--QKEKLWEHEKMQEQEKIWEQEEK 795

Query: 195 -----SKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARS---WAYRDSLKAEENR 246
                 K+  +       +  + G +   W       +  W +    W   + +  +E +
Sbjct: 796 MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWG----QEEKMWGQEEKMWGQEEKMWGQEEK 851

Query: 247 KLQKMKDEQHQKSELLELKRQQQEQER 273
             +KM+ ++ +  E  E  R Q+E+ R
Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMR 878



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 42/221 (19%), Positives = 96/221 (43%), Gaps = 39/221 (17%)

Query: 82  RIAEQELANLEK--WKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKRE 139
           R  EQ++ + E+  W++  R +            + E  +R+++++     K +++ K +
Sbjct: 386 REQEQKMRDQEERMWEQDERLR------------EKEERMREQEKMWEQVEKMREEKKMQ 433

Query: 140 ESVRIKKEAEEAELQKMKAIQREKSNKLEEK---------KRLQENLRREAFREHQQYKT 190
           E  +  ++ EE   ++ +  +REK  + EE+         ++ +EN+  +  +E QQ + 
Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493

Query: 191 AEFLSKL------------NTESPDRSACQSAVCGPQSSTWKLPIL--PRDHSWARSWAY 236
            E   KL              E  ++   Q  + G +   W+   +    D  W +    
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 553

Query: 237 RDSLKA--EENRKLQKMKDEQHQKSELLELKRQQQEQERAK 275
           RD  +   ++  +++K   EQ +K+   E K +++E+ R +
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER 594



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 42/174 (24%), Positives = 82/174 (47%), Gaps = 25/174 (14%)

Query: 116 ETEVRQKQQLQLMQSK---YKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKR 172
           + E R +++ Q  + K    ++K++ EE +R ++E +  E ++M   Q EK  + EEK +
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMR-EREKKMREEEEMMREQEEKMQEQEEKMQ 620

Query: 173 LQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWAR 232
            QE    E     Q+ K  E   K+  +       +  +   +   W+   LP      +
Sbjct: 621 EQEEKMWE-----QEEKMQEQEEKMWEQ-------EEKMWEQEEKMWEQQRLPEQKE--K 666

Query: 233 SWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQ---ERAKIHQTEHRR 283
            W +    K +E  K+Q+ ++E+  + E +E K Q+QE+   ++ K+ + E  R
Sbjct: 667 LWEHE---KMQEQEKMQE-QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR 716



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 33/174 (18%), Positives = 75/174 (43%), Gaps = 11/174 (6%)

Query: 116 ETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQE 175
           E E +  +Q + M+ + ++   +EE +  K + +E +    +   RE+    E +K+++E
Sbjct: 541 EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600

Query: 176 N----LRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWA 231
                  +E   + Q+ K  E   K+  +       +  +   +   W+      +  W 
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE----QEEKMWE 656

Query: 232 RSWAYRDSLKAEENRKLQKMKDEQHQKSELLE---LKRQQQEQERAKIHQTEHR 282
           +        K  E+ K+Q+ +  Q Q+ ++ E   ++++ QEQE+    Q + R
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710



 Score = 32.7 bits (73), Expect = 0.61
 Identities = 33/169 (19%), Positives = 73/169 (43%), Gaps = 7/169 (4%)

Query: 121 QKQQLQLMQSKYKQKLKREE----SVRIKKEAEEAELQKMKAIQREKSNKLEEKK--RLQ 174
           +K ++QL   + K+KL+R +     V+     EE   Q+ +  ++EK  + +E+K  R +
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSW 234
           E LR +  +  +Q +      K   E       Q      Q    +     ++    + W
Sbjct: 300 ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQE-EKMW 358

Query: 235 AYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
              + ++ +E +  ++ +    Q+ ++ E +++ ++QE     Q E  R
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407


>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
          Length = 273

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 44/169 (26%), Positives = 84/169 (49%), Gaps = 23/169 (13%)

Query: 114 QSETEVRQKQQLQLMQSKYKQKLKREESVR-----IKKEAEEAELQKMK-AIQREKSNKL 167
           + E +   ++Q ++ Q + ++KL  EE+ R     + K  EE EL+K K  I+RE   ++
Sbjct: 103 EEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEE-ELEKRKDEIEREVLRRV 161

Query: 168 EEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRD 227
           EE KR+ E   ++   E ++ + AE  ++   E  +R+  +              IL  +
Sbjct: 162 EEAKRIME---KQLLEELERQRQAELAAQKAREEEERAKREELE----------RILEEN 208

Query: 228 HSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKI 276
           +   R  A   +  AEE  ++ + + + H++   LE +RQ+Q++E  KI
Sbjct: 209 N---RKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 30/133 (22%), Positives = 57/133 (42%), Gaps = 7/133 (5%)

Query: 163 KSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLP 222
           KS+K  +K+    +  R+  R  ++ K+ E       ES  RS   +     +    +  
Sbjct: 16  KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERA 75

Query: 223 ILPRDHS--WARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTE 280
             P D    + R+ + R SL  ++ R+ ++ K E  ++ ++     +QQE E   I +  
Sbjct: 76  SSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI-----RQQEIEEKLIEEET 130

Query: 281 HRRVNNAFLDRLQ 293
            RRV      R++
Sbjct: 131 ARRVEELVAKRVE 143



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 43/200 (21%), Positives = 82/200 (41%), Gaps = 16/200 (8%)

Query: 3   TRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAPKGPSRESVVHAGQR 62
           +R+R  ++    S   R       P  R         +R  L+   K    E      ++
Sbjct: 54  SRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQ 113

Query: 63  RTSAYTLIAPNINRRNEIQRI----AEQELANLEKWKEQNRAKPVHLVP--RRLGGSQSE 116
           R      I   +      +R+    A++    LEK K++   + +  V   +R+   Q  
Sbjct: 114 RKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLL 173

Query: 117 TEVRQKQQLQLMQSKYKQ---KLKREESVRIKKEAEE--AELQKMKAIQR----EKSNKL 167
            E+ +++Q +L   K ++   + KREE  RI +E     AE Q   A ++    E+  K+
Sbjct: 174 EELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKI 233

Query: 168 -EEKKRLQENLRREAFREHQ 186
            EE+ +L++  +R+   E +
Sbjct: 234 HEERMKLEQERQRQQKEEQK 253



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 36/211 (17%), Positives = 84/211 (39%), Gaps = 18/211 (8%)

Query: 90  NLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAE 149
           N ++ + ++R++    V +R    +S+   R++ + +   +      +  +  R     +
Sbjct: 21  NKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPD 80

Query: 150 EAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQS 209
             ++      +R   + L+EK++ +E  ++  F   ++ +  E   KL  E   R   + 
Sbjct: 81  RIDIFGRTVSKR---SSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEEL 137

Query: 210 AVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKL----QKMKDEQHQKSELLELK 265
                +    K           +    R+ L+  E  K     Q +++ + Q+   L  +
Sbjct: 138 VAKRVEEELEK----------RKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQ 187

Query: 266 RQQQEQERAKIHQTEH-RRVNNAFLDRLQGK 295
           + ++E+ERAK  + E     NN  +   Q K
Sbjct: 188 KAREEEERAKREELERILEENNRKIAEAQAK 218


>gi|157266264 pleckstrin homology-like domain, family B, member 3
           [Homo sapiens]
          Length = 640

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 71/290 (24%), Positives = 122/290 (42%), Gaps = 36/290 (12%)

Query: 14  ASPASRPTRDPQDPSGRQGELSPVEDQREGLEAAP----------KGPSRESVVHAGQR- 62
           A P+SR   + Q      GE S  E  R+  EA P             SRE V  A +R 
Sbjct: 42  AEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRL 101

Query: 63  ---RTSAYTLIAPNINRRNEIQRIAEQ-------ELANL--EKWKEQNRAKPVHLVPRRL 110
              +  A T +A    R  E+QR  ++       E+A L  E   E+  A+      R L
Sbjct: 102 QGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLREL 161

Query: 111 GGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEK 170
              Q+ +E R +QQ +  Q +  Q+  R E +R +    + +L      QRE+  +  ++
Sbjct: 162 LEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQE 221

Query: 171 KRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSW 230
            R Q ++ + A+ E  +++  E  S+   E  D         GPQ    K+  L    + 
Sbjct: 222 MREQLDVAQRAY-EDLEFQQLERESRQEEEDRDSP-------GPQVPDPKVQELQASMAQ 273

Query: 231 ARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQ----EQERAKI 276
            R  A +  ++  E  +L+ + ++   +S  L  K+++      QER+++
Sbjct: 274 HRRGALQHRIRVLE-EQLKSLGEQMAAESRGLSRKKEEALQALSQERSRL 322


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 49/216 (22%), Positives = 96/216 (44%), Gaps = 17/216 (7%)

Query: 77  RNEIQRIAEQELANLEK--WKEQNRAKPVHLVPRRLGGS-QSETEVRQKQQLQLMQSK-- 131
           + E  R  EQ++ + E+  W++  R +      R      Q E ++R++++ Q  + K  
Sbjct: 491 QEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550

Query: 132 -YKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQEN--LRREAFREHQQY 188
             ++K++ EE +R ++E +  E ++M   Q EK  + EEK R QE     +E   + Q+ 
Sbjct: 551 DQEEKMREEERMR-EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 609

Query: 189 KTAEFLSKL-NTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRK 247
           K  E   K+   E  D+   Q  +   Q    +           + W   + ++ +E + 
Sbjct: 610 KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ-------EQEEKMWEQEEKMREQEEKM 662

Query: 248 LQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
            ++ +  Q Q+ ++ E + + Q QE     Q E  R
Sbjct: 663 REQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 39/184 (21%), Positives = 86/184 (46%), Gaps = 26/184 (14%)

Query: 114 QSETEVRQKQQLQLMQSK-YKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKR 172
           + +  +R+K++    Q K ++Q+ K +E  RI++   E ++++ +   RE+  K++   +
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIRER--EKKMREEEETMREQEEKMQ---K 417

Query: 173 LQENLRREAFREHQQYKTAEFLSKL------------NTESPDRSACQSAVCGPQSSTWK 220
            +EN+  +  +E QQ +  E   KL              E  ++   Q  + G +   W+
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 477

Query: 221 LPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQE--QERAKIHQ 278
              +       + W   + ++ +E    QKM D++ +  E  E  R+++E  +E+ K+ Q
Sbjct: 478 QEKMREQED--QMWEQEEKMRDQE----QKMWDQEERMWEQDERLREKEERMREQKKMWQ 531

Query: 279 TEHR 282
            E +
Sbjct: 532 QEEK 535



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 39/194 (20%), Positives = 87/194 (44%), Gaps = 20/194 (10%)

Query: 92  EKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEA 151
           E W+++   +      R+    Q E   RQ+++L+  + K ++   +EE +R     +E 
Sbjct: 235 EMWRQEEELREQEKKIRK----QEEKMWRQEERLREQEGKMRE---QEEKMR----RQEK 283

Query: 152 ELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAV 211
            L++ +   RE+  +L E+K+L+E   +E   + Q+ K  E   K+  +       +  +
Sbjct: 284 RLREQEKELREQEKELREQKKLRE---QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 340

Query: 212 CGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENR-----KLQKMKDEQHQKSELLELKR 266
              +    +     RD    R W   + L+ +E R     K+ + +++  ++  + E ++
Sbjct: 341 WEQEKQMREQEQKMRDQE-ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREK 399

Query: 267 QQQEQERAKIHQTE 280
           + +E+E     Q E
Sbjct: 400 KMREEEETMREQEE 413



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 52/229 (22%), Positives = 105/229 (45%), Gaps = 34/229 (14%)

Query: 68  TLIAPNINRRN-EIQ---RIAEQELANLE---KWKEQNRAKPVHLVPRRLGGSQSETEVR 120
           T+    + ++N E+Q   R+AE E + ++   K  ++   +   L+P+    +  E   R
Sbjct: 179 TITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR 238

Query: 121 QKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQRE-KSNKLEEKKRLQENLRR 179
           Q+++L            RE+  +I+K+ E+   Q+ +  ++E K  + EEK R QE   R
Sbjct: 239 QEEEL------------REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR 286

Query: 180 EAFRE-HQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRD 238
           E  +E  +Q K      KL  +       +  +   +   W+     R+    + W   +
Sbjct: 287 EQEKELREQEKELREQKKLREQ-------EEQMQEQEEKMWEQEEKMREQE-EKMWRQEE 338

Query: 239 SLKAEENR---KLQKMKDEQHQKSELLELKRQQQE--QERAKIHQTEHR 282
            L  +E +   + QKM+D++ +  E  E  R+++E  +E+ K+ + E +
Sbjct: 339 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK 387



 Score = 35.4 bits (80), Expect = 0.094
 Identities = 37/230 (16%), Positives = 98/230 (42%), Gaps = 43/230 (18%)

Query: 81  QRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSK-YKQKLKRE 139
           QR+ EQ+    E+ K Q + + +          + E ++R ++++   + K ++Q+  RE
Sbjct: 433 QRLPEQKEKLWEQEKMQEQEEKIW---------EQEEKIRDQEEMWGQEKKMWRQEKMRE 483

Query: 140 ESVRIKKEAEEAELQKMKAI--------QREKSNKLEEKKRLQENLRREAFREHQQYKTA 191
           +  ++ ++ E+   Q+ K          Q E+  + EE+ R Q+ + ++  +  ++ KT 
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543

Query: 192 EFLSKLNTESPDRSACQSAVCGPQSSTW----KLPILPRDHSWARSWAYRDSLKAEENRK 247
           E                      +  TW    K+    R     +     + +  E+  K
Sbjct: 544 E---------------------QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 582

Query: 248 LQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGKSQ 297
           +Q+ +++  ++ E +  + ++ +++  K+ + E +       D++Q + +
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE 632



 Score = 32.7 bits (73), Expect = 0.61
 Identities = 36/182 (19%), Positives = 78/182 (42%), Gaps = 14/182 (7%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKL 136
           R E + + EQE   +++ +E+ R +   +  +     + E ++ ++++    Q +  +  
Sbjct: 570 REEEEMMREQE-EKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQ 628

Query: 137 KREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSK 196
           ++EE +  ++E  + + +KM   Q EK  + EEK R QE        + Q+ K  E   K
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWE-QEEKMREQEEKMREQEEK-----MQGQEEKMREQEEK 682

Query: 197 LNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWA---RSWAYRDSLKAEENRKLQKMKD 253
           +  +       +  + G +   W       +  W    + W   +  + EE  + QK K 
Sbjct: 683 MQGQEEKMREQEEKMRGQEEKMWG----QEEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738

Query: 254 EQ 255
           ++
Sbjct: 739 QE 740



 Score = 32.7 bits (73), Expect = 0.61
 Identities = 24/112 (21%), Positives = 55/112 (49%), Gaps = 8/112 (7%)

Query: 81  QRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREE 140
           +++ EQE    + W+++ + +      R         E + ++Q + MQ + ++  ++EE
Sbjct: 639 EKMQEQEE---KMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE 695

Query: 141 SVRIKKEAEEAELQKM-----KAIQREKSNKLEEKKRLQENLRREAFREHQQ 187
            +R ++E    + +KM     K   +E+  + EE+ R Q+   +E   EH++
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 27/103 (26%), Positives = 50/103 (48%), Gaps = 4/103 (3%)

Query: 116 ETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQE 175
           E E + ++Q + MQ + ++  ++EE ++ ++E    + +KM+  Q EK    EEK   QE
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRG-QEEKMWGQEEKMWGQE 715

Query: 176 NLR--REAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQS 216
                +E  RE ++ +  +   K+    P+     S  C P S
Sbjct: 716 EKMWGQEEMREKEE-RIRDQKEKMQERLPEHEERCSEPCLPPS 757


>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
           [Homo sapiens]
          Length = 522

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 44/171 (25%), Positives = 76/171 (44%), Gaps = 12/171 (7%)

Query: 116 ETEVRQKQQLQLMQSKYKQKLK-REESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQ 174
           ET     +  +  ++K + +++ R    R+KKE EEAELQ     + E+   ++  + + 
Sbjct: 150 ETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMV 209

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPD--RSACQSAVCGPQSSTWKLPILPRDHSWAR 232
           + L +EA  E QQ      L+++     D  R A ++ +   QS        PR H   +
Sbjct: 210 KALEKEAASEKQQL-VETHLARVEAMLNDRRRMALENYLAALQSDP------PRPHRILQ 262

Query: 233 SWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
             A R  ++AE   +L  ++  QH  +   E   Q + Q    +H  E RR
Sbjct: 263 --ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 311


>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
           [Homo sapiens]
          Length = 695

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 44/171 (25%), Positives = 76/171 (44%), Gaps = 12/171 (7%)

Query: 116 ETEVRQKQQLQLMQSKYKQKLK-REESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQ 174
           ET     +  +  ++K + +++ R    R+KKE EEAELQ     + E+   ++  + + 
Sbjct: 323 ETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMV 382

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPD--RSACQSAVCGPQSSTWKLPILPRDHSWAR 232
           + L +EA  E QQ      L+++     D  R A ++ +   QS        PR H   +
Sbjct: 383 KALEKEAASEKQQL-VETHLARVEAMLNDRRRMALENYLAALQSDP------PRPHRILQ 435

Query: 233 SWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
             A R  ++AE   +L  ++  QH  +   E   Q + Q    +H  E RR
Sbjct: 436 --ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 484


>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
           [Homo sapiens]
          Length = 751

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 44/171 (25%), Positives = 76/171 (44%), Gaps = 12/171 (7%)

Query: 116 ETEVRQKQQLQLMQSKYKQKLK-REESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQ 174
           ET     +  +  ++K + +++ R    R+KKE EEAELQ     + E+   ++  + + 
Sbjct: 379 ETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMV 438

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPD--RSACQSAVCGPQSSTWKLPILPRDHSWAR 232
           + L +EA  E QQ      L+++     D  R A ++ +   QS        PR H   +
Sbjct: 439 KALEKEAASEKQQL-VETHLARVEAMLNDRRRMALENYLAALQSDP------PRPHRILQ 491

Query: 233 SWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
             A R  ++AE   +L  ++  QH  +   E   Q + Q    +H  E RR
Sbjct: 492 --ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540


>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
           [Homo sapiens]
          Length = 763

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 44/171 (25%), Positives = 76/171 (44%), Gaps = 12/171 (7%)

Query: 116 ETEVRQKQQLQLMQSKYKQKLK-REESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQ 174
           ET     +  +  ++K + +++ R    R+KKE EEAELQ     + E+   ++  + + 
Sbjct: 379 ETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMV 438

Query: 175 ENLRREAFREHQQYKTAEFLSKLNTESPD--RSACQSAVCGPQSSTWKLPILPRDHSWAR 232
           + L +EA  E QQ      L+++     D  R A ++ +   QS        PR H   +
Sbjct: 439 KALEKEAASEKQQL-VETHLARVEAMLNDRRRMALENYLAALQSDP------PRPHRILQ 491

Query: 233 SWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRR 283
             A R  ++AE   +L  ++  QH  +   E   Q + Q    +H  E RR
Sbjct: 492 --ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 54/238 (22%), Positives = 111/238 (46%), Gaps = 35/238 (14%)

Query: 77  RNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSET-EVRQKQ-----QLQLMQS 130
           +NE++++  Q+     K K +   +   L+ R     Q E  E+  K+     + ++   
Sbjct: 665 KNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDK 724

Query: 131 KYKQKLKREESVRIKK----EAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQ 186
           + +  +K++E +R ++    E EE +LQ+   + +++   L+++  LQ   R E  R+H+
Sbjct: 725 ERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQ---LKDQYFLQ---RHELLRKHE 778

Query: 187 QYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLK----- 241
             K  E + + N    ++   +      Q    +LP + R     R   Y+ SL      
Sbjct: 779 --KEREQMQRYNQRMIEQLKVRQ-----QQEKARLPKIQRSEGKTRMAMYKKSLHINGGG 831

Query: 242 --AEENRKLQK--MKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQGK 295
             AE+  K+++   ++E+ QKSE L+ +++ + Q R  + Q E    N + L +LQ +
Sbjct: 832 SAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES---NMSELQQLQNE 886



 Score = 36.6 bits (83), Expect = 0.042
 Identities = 57/289 (19%), Positives = 117/289 (40%), Gaps = 61/289 (21%)

Query: 52  SRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLG 111
           +R+ VV   +   +   +I+ +  +  E++ +  QEL  L   +++              
Sbjct: 530 TRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEH------------ 577

Query: 112 GSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKK 171
             +++T++  K +LQL Q       + E+ +  KK+  + EL+ ++  Q+++  K+E+  
Sbjct: 578 --RNQTQLSNKHELQLEQ----MHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDH 631

Query: 172 --RLQENLRREAFREHQQYKTAEFLSKLNTES--------PDRSACQSAVCGPQSSTWKL 221
             R +E  RR    + + Y   +   KL  +         P +   +S     +  T K 
Sbjct: 632 AVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKK 691

Query: 222 PILPRDHSWARSWAYRDSLK--AEENRK---------LQKMKD------------EQHQK 258
            +L RD    +      ++K    +NR+         L K ++            E+HQ 
Sbjct: 692 QLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQL 751

Query: 259 SELLELKRQQ-------QEQERAKIHQTEH---RRVNNAFLDRLQGKSQ 297
            E  +L +QQ       Q  E  + H+ E    +R N   +++L+ + Q
Sbjct: 752 QERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQ 800


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,101,017
Number of Sequences: 37866
Number of extensions: 763533
Number of successful extensions: 10255
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 250
Number of HSP's successfully gapped in prelim test: 657
Number of HSP's that attempted gapping in prelim test: 5373
Number of HSP's gapped (non-prelim): 3403
length of query: 410
length of database: 18,247,518
effective HSP length: 105
effective length of query: 305
effective length of database: 14,271,588
effective search space: 4352834340
effective search space used: 4352834340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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