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Search of human proteins with 5032173
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5032173 nuclear receptor subfamily 2, group F, member 1
[Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 874 0.0
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 730 0.0
gi|223555949 nuclear receptor subfamily 2, group F, member 2 iso... 514 e-146
gi|223555953 nuclear receptor subfamily 2, group F, member 2 iso... 503 e-142
gi|223555951 nuclear receptor subfamily 2, group F, member 2 iso... 503 e-142
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 501 e-142
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 279 3e-75
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 278 5e-75
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 273 2e-73
gi|11415052 retinoid X receptor, beta [Homo sapiens] 272 5e-73
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 261 1e-69
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho... 230 2e-60
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 219 3e-57
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 219 3e-57
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 219 3e-57
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 219 3e-57
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 216 2e-56
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 216 2e-56
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 216 4e-56
gi|238550159 estrogen-related receptor beta [Homo sapiens] 191 8e-49
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 189 4e-48
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 189 4e-48
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 189 4e-48
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 189 4e-48
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 182 7e-46
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 177 2e-44
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 177 2e-44
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 175 6e-44
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 166 3e-41
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 165 6e-41
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 874 bits (2259), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA 60
MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA
Sbjct: 1 MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA 60
Query: 61 PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY 120
PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY
Sbjct: 61 PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY 120
Query: 121 TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN 180
TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN
Sbjct: 121 TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN 180
Query: 181 GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF 240
GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF
Sbjct: 181 GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF 240
Query: 241 PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR 300
PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR
Sbjct: 241 PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR 300
Query: 301 IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY 360
IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY
Sbjct: 301 IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY 360
Query: 361 PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI 420
PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI
Sbjct: 361 PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI 420
Query: 421 QCS 423
QCS
Sbjct: 421 QCS 423
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 730 bits (1885), Expect = 0.0
Identities = 366/426 (85%), Positives = 379/426 (88%), Gaps = 17/426 (3%)
Query: 1 MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA 60
MAMVVS+WRDPQD+V G + A+QA G GAPHTPQTPGQ G
Sbjct: 1 MAMVVSTWRDPQDEVPGSQG---SQASQAPPVPG---------PPPGAPHTPQTPGQGGP 48
Query: 61 PATPGTAGDKGQGPPGSG-----QSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVR 115
+TP GQG PG Q QQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVR
Sbjct: 49 ASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVR 108
Query: 116 RNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTN 175
RNL+YTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQP GQ+ALTN
Sbjct: 109 RNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTN 168
Query: 176 GDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWAR 235
GDPLN H YLSGYISLLLRAEPYPTSR+GSQCMQPNNIMGIENICELAAR+LFSAVEWAR
Sbjct: 169 GDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWAR 228
Query: 236 NIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAF 295
NIPFFPDLQITDQV+LLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAF
Sbjct: 229 NIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAF 288
Query: 296 MDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEY 355
MDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSD AH+ESLQEKSQCALEEY
Sbjct: 289 MDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEY 348
Query: 356 VRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNW 415
VRSQYPNQP+RFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNW
Sbjct: 349 VRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNW 408
Query: 416 PYMSIQ 421
PYM+IQ
Sbjct: 409 PYMAIQ 414
>gi|223555949 nuclear receptor subfamily 2, group F, member 2
isoform b [Homo sapiens]
Length = 281
Score = 514 bits (1324), Expect = e-146
Identities = 257/275 (93%), Positives = 265/275 (96%)
Query: 147 LKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQ 206
L+ G AVQRGRMPPTQP GQ+ALTNGDPLN H YLSGYISLLLRAEPYPTSR+GSQ
Sbjct: 7 LEQGKYGFAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQ 66
Query: 207 CMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQ 266
CMQPNNIMGIENICELAAR+LFSAVEWARNIPFFPDLQITDQV+LLRLTWSELFVLNAAQ
Sbjct: 67 CMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQ 126
Query: 267 CSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIV 326
CSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIV
Sbjct: 127 CSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIV 186
Query: 327 LFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIE 386
LFTSDACGLSD AH+ESLQEKSQCALEEYVRSQYPNQP+RFGKLLLRLPSLRTVSSSVIE
Sbjct: 187 LFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIE 246
Query: 387 QLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQ 421
QLFFVRLVGKTPIETLIRDMLLSGSSFNWPYM+IQ
Sbjct: 247 QLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 281
>gi|223555953 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 503 bits (1294), Expect = e-142
Identities = 249/261 (95%), Positives = 256/261 (98%)
Query: 161 MPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENIC 220
MPPTQP GQ+ALTNGDPLN H YLSGYISLLLRAEPYPTSR+GSQCMQPNNIMGIENIC
Sbjct: 1 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC 60
Query: 221 ELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAA 280
ELAAR+LFSAVEWARNIPFFPDLQITDQV+LLRLTWSELFVLNAAQCSMPLHVAPLLAAA
Sbjct: 61 ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA 120
Query: 281 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAH 340
GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSD AH
Sbjct: 121 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH 180
Query: 341 IESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 400
+ESLQEKSQCALEEYVRSQYPNQP+RFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE
Sbjct: 181 VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 240
Query: 401 TLIRDMLLSGSSFNWPYMSIQ 421
TLIRDMLLSGSSFNWPYM+IQ
Sbjct: 241 TLIRDMLLSGSSFNWPYMAIQ 261
>gi|223555951 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 503 bits (1294), Expect = e-142
Identities = 249/261 (95%), Positives = 256/261 (98%)
Query: 161 MPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENIC 220
MPPTQP GQ+ALTNGDPLN H YLSGYISLLLRAEPYPTSR+GSQCMQPNNIMGIENIC
Sbjct: 1 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC 60
Query: 221 ELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAA 280
ELAAR+LFSAVEWARNIPFFPDLQITDQV+LLRLTWSELFVLNAAQCSMPLHVAPLLAAA
Sbjct: 61 ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA 120
Query: 281 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAH 340
GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSD AH
Sbjct: 121 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH 180
Query: 341 IESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 400
+ESLQEKSQCALEEYVRSQYPNQP+RFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE
Sbjct: 181 VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 240
Query: 401 TLIRDMLLSGSSFNWPYMSIQ 421
TLIRDMLLSGSSFNWPYM+IQ
Sbjct: 241 TLIRDMLLSGSSFNWPYMAIQ 261
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 501 bits (1291), Expect = e-142
Identities = 261/434 (60%), Positives = 309/434 (71%), Gaps = 43/434 (9%)
Query: 1 MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA 60
MAMV W P D G + G P A + S +P + +PG
Sbjct: 1 MAMVTGGWGGPGGDTNGVDKAGGYPRAA--------------EDDSASPPGAASDAEPGD 46
Query: 61 PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY 120
PG ++CVVCGDKSSGKHYG FTCEGCKSFFKRS+RRNL+Y
Sbjct: 47 EERPGL----------------QVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSY 90
Query: 121 TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPN---------PGQY 171
TCR+NR+C IDQHHRNQCQYCRLKKC +VGMR+EAVQRGR+P + P PG
Sbjct: 91 TCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSA 150
Query: 172 --ALTNGDPLNGHCYLSGYISLLLRAEPYPTS--RYGSQCMQPNNIMGIENICELAARLL 227
A+ +G L +S I+ LLRAEPYP + R+G+ ++GI+N+CELAARLL
Sbjct: 151 LAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLL 210
Query: 228 FSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPM 287
FS VEWAR+ PFFP+L + DQV+LLRL+WSELFVLNAAQ ++PLH APLLAAAGLHA+PM
Sbjct: 211 FSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPM 270
Query: 288 SADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEK 347
+A+R VAFMD +R FQEQV+KL L VDSAEY CLKAI LFT DACGLSD AH+ESLQEK
Sbjct: 271 AAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEK 330
Query: 348 SQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
+Q AL EYVR+QYP+QP RFG+LLLRLP+LR V +S+I QLFF+RLVGKTPIETLIRDML
Sbjct: 331 AQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDML 390
Query: 408 LSGSSFNWPYMSIQ 421
LSGS+FNWPY S Q
Sbjct: 391 LSGSTFNWPYGSGQ 404
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 279 bits (714), Expect = 3e-75
Identities = 150/354 (42%), Positives = 208/354 (58%), Gaps = 20/354 (5%)
Query: 61 PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY 120
P PG G+ G +HI C +CGD+SSGKHYG ++CEGCK FFKR++R++L Y
Sbjct: 116 PGLPGI-GNMNYPSTSPGSLVKHI-CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIY 173
Query: 121 TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN 180
TCR N++C ID+ RN+CQYCR +KCL +GM+REAVQ R + +
Sbjct: 174 TCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESE---------- 223
Query: 181 GHCYLSGY----ISLLLRAE---PYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEW 233
C SG+ + +L AE T YG M+ + + NIC A + LF+ VEW
Sbjct: 224 AECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEW 283
Query: 234 ARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVV 293
A+ IP F DL + DQV LLR W+EL + + + S+ + +L A GLH SA
Sbjct: 284 AKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDG-ILLATGLHVHRSSAHSAG 342
Query: 294 AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALE 353
R+ E V K+K + +D +E CL+AIVLF DA GLS+ + +E+L+EK LE
Sbjct: 343 VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLE 402
Query: 354 EYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
Y + +YP QP RF KLLLRLP+LR++ +E LFF +L+G TPI+T + +ML
Sbjct: 403 AYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 456
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 278 bits (712), Expect = 5e-75
Identities = 144/336 (42%), Positives = 206/336 (61%), Gaps = 5/336 (1%)
Query: 74 PPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQH 133
P G+ S C +CGD+SSGKHYG ++CEGCK FFKR+VR++LTYTCR N++C ID+
Sbjct: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
Query: 134 HRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTN--GDPLNGHCYLSGYISL 191
RN+CQYCR +KCL +GM+REAVQ R N + T+ + + L +++
Sbjct: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAV 242
Query: 192 LLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSL 251
+ E Y + G PN+ + NIC+ A + LF+ VEWA+ IP F +L + DQV L
Sbjct: 243 EPKTETYVEANMGLNPSSPND--PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
Query: 252 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 311
LR W+EL + + + S+ + +L A GLH SA R+ E V K++
Sbjct: 301 LRAGWNELLIASFSHRSIAVKDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRD 359
Query: 312 LHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLL 371
+ +D E CL+AIVLF D+ GLS+ A +E+L+EK +LE Y + +YP QP RF KLL
Sbjct: 360 MQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLL 419
Query: 372 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
LRLP+LR++ +E LFF +L+G TPI+T + +ML
Sbjct: 420 LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 273 bits (699), Expect = 2e-73
Identities = 159/406 (39%), Positives = 224/406 (55%), Gaps = 63/406 (15%)
Query: 46 SGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEG 105
+GA ++PG+ G G+ P G S ++C VCGD SSGKHYG + C G
Sbjct: 20 AGAASRKESPGRWGL----------GEDPTGVSPS---LQCRVCGDSSSGKHYGIYACNG 66
Query: 106 CKSFFKRSVRRNLTYTCRANRN-CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPT 164
C FFKRSVRR L Y C+ CP+D+ HRNQCQ CRLKKCL+ GM ++AVQ R P +
Sbjct: 67 CSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRS 126
Query: 165 Q----------------------PNPGQYALTNGDPLN-----GHCYLSGYISL--LLRA 195
P P + P++ GH +++ I+ +
Sbjct: 127 TAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKL 186
Query: 196 EP---------------YPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF 240
EP +P+S Y S ++ G+++I E +ARLLF AV+WA+N+P F
Sbjct: 187 EPEDADENIDVTSNDPEFPSSPYSS-----SSPCGLDSIHETSARLLFMAVKWAKNLPVF 241
Query: 241 PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR 300
L DQV LL WSELF+L A Q S+PL PLLA A+ + R+ R
Sbjct: 242 SSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETR 301
Query: 301 IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY 360
+ QE + + +AL VD E++C+KA+VLF + GL D H+E+LQ++SQ L ++ ++ +
Sbjct: 302 VLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHH 361
Query: 361 PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDM 406
P+QP RFGKLLL LPSLR +++ IE LFF + +G TP+E L+ DM
Sbjct: 362 PSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 272 bits (695), Expect = 5e-73
Identities = 153/396 (38%), Positives = 221/396 (55%), Gaps = 16/396 (4%)
Query: 18 GNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGS 77
G+PG P PA G G Q + P P + P G G PPG
Sbjct: 141 GSPGLPPPAPP---GFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGG 197
Query: 78 GQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQ 137
+ + + C +CGD+SSGKHYG ++CEGCK FFKR++R++LTY+CR N++C +D+ RN+
Sbjct: 198 PGAGKRL-CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNR 256
Query: 138 CQYCRLKKCLKVGMRREAVQRGRM-PPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAE 196
CQYCR +KCL GM+REAVQ R + G+ A + + L +++ +++
Sbjct: 257 CQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSD 316
Query: 197 -----PYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSL 251
P T GS P + NIC+ A + LF+ VEWA+ IP F L + DQV L
Sbjct: 317 QGVEGPGGTGGSGSSPNDP-----VTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
Query: 252 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 311
LR W+EL + + + S+ + +L A GLH SA R+ E V K++
Sbjct: 372 LRAGWNELLIASFSHRSIDVRDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRD 430
Query: 312 LHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLL 371
+ +D E CL+AI+LF DA GLS+ + +E L+EK +LE Y + +YP Q RF KLL
Sbjct: 431 MRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLL 490
Query: 372 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
LRLP+LR++ +E LFF +L+G TPI+T + +ML
Sbjct: 491 LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 526
Score = 38.5 bits (88), Expect = 0.012
Identities = 26/80 (32%), Positives = 33/80 (41%), Gaps = 12/80 (15%)
Query: 8 WRDPQDD----VAGGNPGGPNPA-AQAARGGGGGAGEQQQQAGSGAPHT-------PQTP 55
W DP VAGG P P +A R G G +G + S +P+ P P
Sbjct: 42 WLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPP 101
Query: 56 GQPGAPATPGTAGDKGQGPP 75
G P P+T + G G PP
Sbjct: 102 GPPLPPSTAPSLGGSGAPPP 121
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 261 bits (666), Expect = 1e-69
Identities = 147/389 (37%), Positives = 212/389 (54%), Gaps = 63/389 (16%)
Query: 74 PPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRN--CPID 131
P GS I C VCGD+SSGKHYG + C+GC FFKRS+RRN TY C++ CP+D
Sbjct: 4 PAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVD 63
Query: 132 QHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSG---- 187
+ HRNQC+ CRLKKCL+V M ++AVQ R P T Q AL GH +G
Sbjct: 64 KTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALY----FRGHKEENGAAAH 119
Query: 188 ----------YISLLLRAEPY---------------------PTSRYGSQCMQPNNIMGI 216
+ + + + EP+ PT +Y P+ + G
Sbjct: 120 FPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKY------PHEVNGT 173
Query: 217 ---------ENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQC 267
E++CE AARLLF +++WA+++P F L + DQ+ LL W ELFVL AQ
Sbjct: 174 PMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQW 233
Query: 268 SMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVL 327
++P+ LLA +G++ + ++ + I+ QE V + + L +D+ E++CLK IV
Sbjct: 234 AIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVT 293
Query: 328 FT-------SDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
F S+ +AA I +LQ+++Q L Y+ ++YP QP RFGKLLL LP+LR++
Sbjct: 294 FKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSI 353
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLS 409
S S IE++FF + +G PI L+ DM S
Sbjct: 354 SPSTIEEVFFKKTIGNVPITRLLSDMYKS 382
>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
sapiens]
Length = 367
Score = 230 bits (587), Expect = 2e-60
Identities = 136/366 (37%), Positives = 194/366 (53%), Gaps = 63/366 (17%)
Query: 46 SGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEG 105
+GA ++PG+ G G+ P G S ++C VCGD SSGKHYG + C G
Sbjct: 20 AGAASRKESPGRWGL----------GEDPTGVSPS---LQCRVCGDSSSGKHYGIYACNG 66
Query: 106 CKSFFKRSVRRNLTYTCRANRN-CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPT 164
C FFKRSVRR L Y C+ CP+D+ HRNQCQ CRLKKCL+ GM ++AVQ R P +
Sbjct: 67 CSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRS 126
Query: 165 Q----------------------PNPGQYALTNGDPLN-----GHCYLSGYISL--LLRA 195
P P + P++ GH +++ I+ +
Sbjct: 127 TAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKL 186
Query: 196 EP---------------YPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF 240
EP +P+S Y S ++ G+++I E +ARLLF AV+WA+N+P F
Sbjct: 187 EPEDADENIDVTSNDPEFPSSPYSS-----SSPCGLDSIHETSARLLFMAVKWAKNLPVF 241
Query: 241 PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR 300
L DQV LL WSELF+L A Q S+PL PLLA A+ + R+ R
Sbjct: 242 SSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETR 301
Query: 301 IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY 360
+ QE + + +AL VD E++C+KA+VLF + GL D H+E+LQ++SQ L ++ ++ +
Sbjct: 302 VLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHH 361
Query: 361 PNQPSR 366
P+QP R
Sbjct: 362 PSQPVR 367
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 219 bits (559), Expect = 3e-57
Identities = 128/337 (37%), Positives = 192/337 (56%), Gaps = 17/337 (5%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 172
Query: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
Query: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
Query: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 417
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 219 bits (559), Expect = 3e-57
Identities = 128/337 (37%), Positives = 192/337 (56%), Gaps = 17/337 (5%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 172
Query: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
Query: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
Query: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 417
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 219 bits (559), Expect = 3e-57
Identities = 128/337 (37%), Positives = 192/337 (56%), Gaps = 17/337 (5%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 150
Query: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
Query: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
Query: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 417
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 219 bits (559), Expect = 3e-57
Identities = 128/337 (37%), Positives = 192/337 (56%), Gaps = 17/337 (5%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 150
Query: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
Query: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
Query: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 417
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 216 bits (551), Expect = 2e-56
Identities = 126/330 (38%), Positives = 188/330 (56%), Gaps = 17/330 (5%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 172
Query: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
Query: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
Query: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSG 410
+ +IEQ+ F++L G I+ L+++MLL G
Sbjct: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 377
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 216 bits (551), Expect = 2e-56
Identities = 126/330 (38%), Positives = 188/330 (56%), Gaps = 17/330 (5%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 146 CLKVGMRREAVQ--RGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRY 203
C + GM++EAVQ R R+ + + +L + + L +L R P S
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALL-------QAEVLSRQITSPVSGI 150
Query: 204 GSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLN 263
++ I I ++CE L VEWA+ IP F +L + DQV+LLR E +L
Sbjct: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
Query: 264 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
Query: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
LKAI+ F DA GLSD I+ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSG 410
+ +IEQ+ F++L G I+ L+++MLL G
Sbjct: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 355
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 216 bits (549), Expect = 4e-56
Identities = 124/332 (37%), Positives = 192/332 (57%), Gaps = 18/332 (5%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C +CGD+++GKHYG +C+GCK FF+RS+R++ Y+CR +R C +D+ RNQC+YCRL+K
Sbjct: 49 CAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRK 108
Query: 146 CLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYP-----T 200
C + GM++EAVQ N T +G S I+ L +AE +
Sbjct: 109 CFRAGMKKEAVQ---------NERDRISTRRSTFDGSNIPS--INTLAQAEVRSRQISVS 157
Query: 201 SRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELF 260
S S + I I ++CE + L VEWA+ IP F +L + DQV+LLR E
Sbjct: 158 SPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL 217
Query: 261 VLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 320
+L A + SM ++ LL S + ++ + + R+ E V + + +D EY+
Sbjct: 218 LLGATKRSM-MYKDILLLGNNYVIHRNSCEVEISRVAN-RVLDELVRPFQEIQIDDNEYA 275
Query: 321 CLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
CLKAIV F DA GLSD I++++ + Q LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 276 CLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSI 335
Query: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSS 412
+ +IEQ+ FV+L G I+ L+++MLL G+S
Sbjct: 336 TWQMIEQIQFVKLFGMVKIDNLLQEMLLGGAS 367
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 191 bits (486), Expect = 8e-49
Identities = 112/329 (34%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
Query: 146 CLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPL-------NGHCYLSGYISLLLRAEPY 198
CLKVGM +E V+ R+ + + + P L+ +S LL AEP
Sbjct: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPD 222
Query: 199 PTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
M +I + +C+LA R L + WA++IP F L + DQ+SLL+ W E
Sbjct: 223 KLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWME 282
Query: 259 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 318
+ +L S+P L A + R+ ++ R + V + K L V+ E
Sbjct: 283 ILILGIVYRSLPYD--DKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEE 340
Query: 319 YSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLR 378
+ LKA+ L SD+ + D ++ LQ+ AL++Y SQ +P R GKLLL LP LR
Sbjct: 341 FVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLR 400
Query: 379 TVSSSVIEQLFFVRLVGKTPIETLIRDML 407
++ ++ + V+L GK P+ L +ML
Sbjct: 401 QTAAKAVQHFYSVKLQGKVPMHKLFLEML 429
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 189 bits (480), Expect = 4e-48
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 164
Query: 146 CLKVGMRREAVQRGRM-PPTQPNPGQYALTNGDPLNGHCY------LSGYISLLLRAEPY 198
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 165 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 224
Query: 199 PTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
+ ++I + +C+LA R L + WA++IP F L + DQ+SLL+ W E
Sbjct: 225 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 284
Query: 259 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 318
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 285 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 342
Query: 319 YSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLR 378
+ LKAI L SD+ + D ++ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 379 TVSSSVIEQLFFVRLVGKTPIETLIRDML 407
S+ ++ + ++L GK P+ L +ML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 189 bits (480), Expect = 4e-48
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 164
Query: 146 CLKVGMRREAVQRGRM-PPTQPNPGQYALTNGDPLNGHCY------LSGYISLLLRAEPY 198
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 165 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 224
Query: 199 PTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
+ ++I + +C+LA R L + WA++IP F L + DQ+SLL+ W E
Sbjct: 225 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 284
Query: 259 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 318
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 285 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 342
Query: 319 YSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLR 378
+ LKAI L SD+ + D ++ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 379 TVSSSVIEQLFFVRLVGKTPIETLIRDML 407
S+ ++ + ++L GK P+ L +ML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 189 bits (480), Expect = 4e-48
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 128 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 187
Query: 146 CLKVGMRREAVQRGRM-PPTQPNPGQYALTNGDPLNGHCY------LSGYISLLLRAEPY 198
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 188 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 247
Query: 199 PTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
+ ++I + +C+LA R L + WA++IP F L + DQ+SLL+ W E
Sbjct: 248 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 307
Query: 259 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 318
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 308 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 365
Query: 319 YSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLR 378
+ LKAI L SD+ + D ++ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 366 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 425
Query: 379 TVSSSVIEQLFFVRLVGKTPIETLIRDML 407
S+ ++ + ++L GK P+ L +ML
Sbjct: 426 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 454
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 189 bits (480), Expect = 4e-48
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 164
Query: 146 CLKVGMRREAVQRGRM-PPTQPNPGQYALTNGDPLNGHCY------LSGYISLLLRAEPY 198
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 165 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 224
Query: 199 PTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
+ ++I + +C+LA R L + WA++IP F L + DQ+SLL+ W E
Sbjct: 225 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 284
Query: 259 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 318
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 285 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 342
Query: 319 YSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLR 378
+ LKAI L SD+ + D ++ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 379 TVSSSVIEQLFFVRLVGKTPIETLIRDML 407
S+ ++ + ++L GK P+ L +ML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 182 bits (461), Expect = 7e-46
Identities = 126/389 (32%), Positives = 184/389 (47%), Gaps = 33/389 (8%)
Query: 49 PHTPQTPGQPGAPATPGTAGDK-----GQGPPGSGQ----SQQHIECVVCGDKSSGKHYG 99
P PG PG ++ G G G G+ S C+VCGD +SG HYG
Sbjct: 33 PPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYG 92
Query: 100 QFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQ-- 157
+CE CK+FFKR+++ ++ Y+C A+ C I + R CQ CR KCL+VGM +E V+
Sbjct: 93 VASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLD 152
Query: 158 --RG------RMPPTQPNP-------GQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSR 202
RG R P P P G A+ G P ++ +S LL EP
Sbjct: 153 RVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGG-PRKTAAPVNALVSHLLVVEPEKLYA 211
Query: 203 YGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVL 262
++ + +C+L R + + WA++IP F L ++DQ+S+L+ W E+ VL
Sbjct: 212 MPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVL 271
Query: 263 NAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCL 322
AQ S+PL LA A R + + V +L+AL ++ EY L
Sbjct: 272 GVAQRSLPLQ--DELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLL 329
Query: 323 KAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY----PNQPSRFGKLLLRLPSLR 378
KA+ L SD+ + DA +E L+E AL EY + + R G+LLL LP LR
Sbjct: 330 KALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLR 389
Query: 379 TVSSSVIEQLFFVRLVGKTPIETLIRDML 407
+ V+ + V+L GK P+ L +ML
Sbjct: 390 QTAGKVLAHFYGVKLEGKVPMHKLFLEML 418
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 177 bits (449), Expect = 2e-44
Identities = 133/421 (31%), Positives = 197/421 (46%), Gaps = 44/421 (10%)
Query: 20 PGGPNPA----------AQAARGGGGGAGEQQQQAGSG-APHTPQTPGQPGAPATPGTAG 68
P GP+P+ +QA G G A G AP +P G G TP T+
Sbjct: 195 PTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGS-GILDTPVTST 253
Query: 69 DKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNC 128
G PG + + C VCGD +S +HYG TCEGCK FFKR+V++N Y C AN++C
Sbjct: 254 KARSGAPGGSEGR----CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDC 309
Query: 129 PIDQHHRNQCQYCRLKKCLKVGMRREAVQ-------RGRMPPTQPNPGQYALTNGDPLNG 181
P+D+ RN+CQ+CR +KCL VGM +E V+ RGR+P P + P N
Sbjct: 310 PVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP-----PDASPAN- 363
Query: 182 HCYLSGYISLLLRAEPYPTSRYGSQCMQ-------PNNIMGIENICELAARLLFSAVEWA 234
L+ + L + P S+ + + ++ +L + L +WA
Sbjct: 364 --LLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWA 421
Query: 235 RNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVA 294
IP F +L DQ LL + ELF+L A S P L+ +GL + R
Sbjct: 422 EKIPGFAELSPADQDLLLESAFLELFILRLAYRSKP-GEGKLIFCSGLVLHRLQCAR--G 478
Query: 295 FMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEE 354
F D I L +L VD ++CL A+VL T D GL + +E LQ + L+E
Sbjct: 479 FGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKE 537
Query: 355 YVR--SQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSS 412
+V + P S +LL +LP LRT+ + ++++F+++L P +I + +
Sbjct: 538 HVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLP 597
Query: 413 F 413
F
Sbjct: 598 F 598
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 177 bits (449), Expect = 2e-44
Identities = 133/421 (31%), Positives = 197/421 (46%), Gaps = 44/421 (10%)
Query: 20 PGGPNPA----------AQAARGGGGGAGEQQQQAGSG-APHTPQTPGQPGAPATPGTAG 68
P GP+P+ +QA G G A G AP +P G G TP T+
Sbjct: 195 PTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGS-GILDTPVTST 253
Query: 69 DKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNC 128
G PG + + C VCGD +S +HYG TCEGCK FFKR+V++N Y C AN++C
Sbjct: 254 KARSGAPGGSEGR----CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDC 309
Query: 129 PIDQHHRNQCQYCRLKKCLKVGMRREAVQ-------RGRMPPTQPNPGQYALTNGDPLNG 181
P+D+ RN+CQ+CR +KCL VGM +E V+ RGR+P P + P N
Sbjct: 310 PVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP-----PDASPAN- 363
Query: 182 HCYLSGYISLLLRAEPYPTSRYGSQCMQ-------PNNIMGIENICELAARLLFSAVEWA 234
L+ + L + P S+ + + ++ +L + L +WA
Sbjct: 364 --LLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWA 421
Query: 235 RNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVA 294
IP F +L DQ LL + ELF+L A S P L+ +GL + R
Sbjct: 422 EKIPGFAELSPADQDLLLESAFLELFILRLAYRSKP-GEGKLIFCSGLVLHRLQCAR--G 478
Query: 295 FMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEE 354
F D I L +L VD ++CL A+VL T D GL + +E LQ + L+E
Sbjct: 479 FGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKE 537
Query: 355 YVR--SQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSS 412
+V + P S +LL +LP LRT+ + ++++F+++L P +I + +
Sbjct: 538 HVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLP 597
Query: 413 F 413
F
Sbjct: 598 F 598
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 175 bits (444), Expect = 6e-44
Identities = 129/424 (30%), Positives = 196/424 (46%), Gaps = 38/424 (8%)
Query: 20 PGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKG-------- 71
PG P + Q G + AGS QT P P + G G
Sbjct: 183 PGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQ 242
Query: 72 ------QGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRAN 125
PP G C VCGD ++ +HYG TCEGCK FFKR+V++N Y C AN
Sbjct: 243 LLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLAN 302
Query: 126 RNCPIDQHHRNQCQYCRLKKCLKVGMRREAV-------QRGRMPPTQPNPGQYALTNGDP 178
+NCP+D+ RN+CQYCR +KCL VGM +E V +RGR+ P++P Q P
Sbjct: 303 KNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRL-PSKPKSPQEPSPPSPP 361
Query: 179 LNGHCYLSGYISLLLRAEPYPTSRYGSQC-------MQPNNIMGIENICELAARLLFSAV 231
++ +S + + + P TS S+ M ++ I+ +L +
Sbjct: 362 VS---LISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIR 418
Query: 232 EWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADR 291
WA IP F DL DQ L + ELFVL A S P+ L+ G+ + R
Sbjct: 419 GWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVE-GKLIFCNGVVLHRLQCVR 477
Query: 292 VVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCA 351
F + I E L+ +++D + +SC+ A+ + T + GL + +E LQ K
Sbjct: 478 --GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQNKIVNC 534
Query: 352 LEEYV--RSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLS 409
L+++V + N+P+ KLL +LP LRT+ + ++++F+++L P +I + L
Sbjct: 535 LKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLD 594
Query: 410 GSSF 413
F
Sbjct: 595 TLPF 598
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 166 bits (421), Expect = 3e-41
Identities = 126/423 (29%), Positives = 198/423 (46%), Gaps = 58/423 (13%)
Query: 21 GGPNPAAQAARGGGGG---AGEQQ----QQAGSGAPHTPQTPGQPGAPATPGTAGDKGQG 73
G P A R GG AG + Q A + T T + P++P
Sbjct: 17 GAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTSSEEMVPSSPSPP------ 70
Query: 74 PPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQH 133
PP + + C VC DKSSG HYG +CEGCK FF+RS+++N+ YTC ++NC I++
Sbjct: 71 PP----PRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKV 126
Query: 134 HRNQCQYCRLKKCLKVGMRREAVQRGRMP-----PTQPNPGQYALTNGDPLNGHCYLSGY 188
RN+CQYCRL+KC +VGM +EAV+ R + +P Y L+ L
Sbjct: 127 TRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSP--------QLEEL 178
Query: 189 ISLLLRA--EPYPT----SRYGSQCMQPNNI---MGI-ENICELAARLLFSAVEWARNIP 238
I+ + +A E +P+ +Y + + + +G+ + ELA + + VE+A+ +P
Sbjct: 179 ITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLP 238
Query: 239 FFPDLQITDQVSLLRLTWSELFVLNAA------QCSMPLHVAPLLAAAGLHASPMS--AD 290
F L I DQ++LL+ ++ +L Q +M L +H + D
Sbjct: 239 GFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 298
Query: 291 RVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQC 350
V AF +L L +D E L AI L D L + ++ LQE
Sbjct: 299 LVFAF----------AGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLE 348
Query: 351 ALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSG 410
AL Y R + P+QP F ++L+++ LR +S+ E+ +++ P+ LIR+ML +
Sbjct: 349 ALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENP 408
Query: 411 SSF 413
F
Sbjct: 409 EMF 411
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 165 bits (418), Expect = 6e-41
Identities = 119/403 (29%), Positives = 193/403 (47%), Gaps = 51/403 (12%)
Query: 34 GGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKS 93
G G + ++ S + T T + P++P PP + + C VC DKS
Sbjct: 48 GLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPP------PP----PRVYKPCFVCNDKS 97
Query: 94 SGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRR 153
SG HYG +CEGCK FF+RS+++N+ YTC ++NC I++ RN+CQYCRL+KC +VGM +
Sbjct: 98 SGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSK 157
Query: 154 EAVQRGRMP-----PTQPNPGQYALTNGDPLNGHCYLSGYISLLLRA--EPYPT----SR 202
EAV+ R + +P Y L+ L I+ + +A E +P+ +
Sbjct: 158 EAVRNDRNKKKKEVKEEGSPDSYELSP--------QLEELITKVSKAHQETFPSLCQLGK 209
Query: 203 YGSQCMQPNNI---MGI-ENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
Y + + + +G+ + ELA + + VE+A+ +P F L I DQ++LL+ +
Sbjct: 210 YTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLD 269
Query: 259 LFVLNAA------QCSMPLHVAPLLAAAGLHASPMS--ADRVVAFMDHIRIFQEQVEKLK 310
+ +L Q +M L +H + D V AF +L
Sbjct: 270 ILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAF----------AGQLL 319
Query: 311 ALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKL 370
L +D E L AI L D L + ++ LQE AL Y R + P+QP F ++
Sbjct: 320 PLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRM 379
Query: 371 LLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSF 413
L+++ LR +S+ E+ +++ P+ LIR+ML + F
Sbjct: 380 LMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMF 422
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,486,605
Number of Sequences: 37866
Number of extensions: 1101109
Number of successful extensions: 24100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 378
Number of HSP's successfully gapped in prelim test: 455
Number of HSP's that attempted gapping in prelim test: 8390
Number of HSP's gapped (non-prelim): 7706
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.