BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens] (346 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 691 0.0 gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 684 0.0 gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo s... 485 e-137 gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo s... 485 e-137 gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] 121 1e-27 gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] 121 1e-27 gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sa... 111 1e-24 gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo ... 100 2e-21 gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo... 91 2e-18 gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] 87 3e-17 gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] 58 1e-08 gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] 56 5e-08 gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] 56 5e-08 gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] 48 1e-05 gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo... 48 1e-05 gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] 37 0.026 gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] 37 0.026 gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] 37 0.026 gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] 35 0.13 gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] 35 0.13 gi|193788653 hypothetical protein LOC100131897 [Homo sapiens] 31 1.9 gi|109809739 La ribonucleoprotein domain family, member 7 [Homo ... 30 4.1 gi|109809741 La ribonucleoprotein domain family, member 7 [Homo ... 30 4.1 gi|189027141 abhydrolase domain containing 6 [Homo sapiens] 28 9.2 gi|104526627 triadin [Homo sapiens] 28 9.2 gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens] 28 9.2 >gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens] Length = 346 Score = 691 bits (1784), Expect = 0.0 Identities = 346/346 (100%), Positives = 346/346 (100%) Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180 Query: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY Sbjct: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 Query: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA Sbjct: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300 Query: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK Sbjct: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346 >gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sapiens] Length = 346 Score = 684 bits (1765), Expect = 0.0 Identities = 342/346 (98%), Positives = 343/346 (99%) Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGD FGYHGYTFANLGEHEFVEE+T Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETD 180 Query: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 VAKVS GVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY Sbjct: 181 VAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 Query: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA Sbjct: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300 Query: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK Sbjct: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346 >gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo sapiens] Length = 266 Score = 485 bits (1248), Expect = e-137 Identities = 244/244 (100%), Positives = 244/244 (100%) Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180 Query: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY Sbjct: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 Query: 241 FLLQ 244 FLLQ Sbjct: 241 FLLQ 244 >gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo sapiens] Length = 299 Score = 485 bits (1248), Expect = e-137 Identities = 244/244 (100%), Positives = 244/244 (100%) Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60 Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120 Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180 Query: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY Sbjct: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240 Query: 241 FLLQ 244 FLLQ Sbjct: 241 FLLQ 244 >gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] Length = 1058 Score = 121 bits (303), Expect = 1e-27 Identities = 105/389 (26%), Positives = 158/389 (40%), Gaps = 65/389 (16%) Query: 9 GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68 G ++ + Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D Sbjct: 45 GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104 Query: 69 EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128 D +QF +R +G+NRAE S R LN V V T + E F + F Sbjct: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLV---EDFLSGFQV 161 Query: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEK---------- 178 V LT + ++V + CH IK D G G F + GE + + Sbjct: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221 Query: 179 TKVAKVSQGVEDGPDTKRAKLDSSE----------------------------------- 203 + V K + GV D R +S + Sbjct: 222 SMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTS 281 Query: 204 ------------TTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRT 251 V KK+ F + +L A R + Q L +F Sbjct: 282 NFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCA 341 Query: 252 DKGRDPSSDTYEEDSELLLQIRNDVLDSL-GISPDLLPEDFVR----YCFSEMAPVCAVV 306 GR P E+ +EL+ + +L + + L ED +R ++AP+ A + Sbjct: 342 QHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFI 401 Query: 307 GGILAQEIVKALSQRDPPHNNFFFFDGMK 335 GG+ AQE++KA S + P + +FD ++ Sbjct: 402 GGLAAQEVMKACSGKFMPIMQWLYFDALE 430 Score = 48.5 bits (114), Expect = 9e-06 Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%) Query: 18 QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72 +YD Q+ ++G + Q++L + LVG +G E+ KN + G+ + + D + + Sbjct: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509 Query: 73 PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125 + QFL R V + +++ + + +NP + V DTE I + FF Sbjct: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567 Query: 126 FDAVCLTCCSRDVIVKVDQIC 146 D V + D + +D+ C Sbjct: 568 LDGVANALDNVDARMYMDRRC 588 >gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] Length = 1058 Score = 121 bits (303), Expect = 1e-27 Identities = 105/389 (26%), Positives = 158/389 (40%), Gaps = 65/389 (16%) Query: 9 GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68 G ++ + Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D Sbjct: 45 GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104 Query: 69 EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128 D +QF +R +G+NRAE S R LN V V T + E F + F Sbjct: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLV---EDFLSGFQV 161 Query: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEK---------- 178 V LT + ++V + CH IK D G G F + GE + + Sbjct: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221 Query: 179 TKVAKVSQGVEDGPDTKRAKLDSSE----------------------------------- 203 + V K + GV D R +S + Sbjct: 222 SMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTS 281 Query: 204 ------------TTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRT 251 V KK+ F + +L A R + Q L +F Sbjct: 282 NFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCA 341 Query: 252 DKGRDPSSDTYEEDSELLLQIRNDVLDSL-GISPDLLPEDFVR----YCFSEMAPVCAVV 306 GR P E+ +EL+ + +L + + L ED +R ++AP+ A + Sbjct: 342 QHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFI 401 Query: 307 GGILAQEIVKALSQRDPPHNNFFFFDGMK 335 GG+ AQE++KA S + P + +FD ++ Sbjct: 402 GGLAAQEVMKACSGKFMPIMQWLYFDALE 430 Score = 48.5 bits (114), Expect = 9e-06 Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%) Query: 18 QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72 +YD Q+ ++G + Q++L + LVG +G E+ KN + G+ + + D + + Sbjct: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509 Query: 73 PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125 + QFL R V + +++ + + +NP + V DTE I + FF Sbjct: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567 Query: 126 FDAVCLTCCSRDVIVKVDQIC 146 D V + D + +D+ C Sbjct: 568 LDGVANALDNVDARMYMDRRC 588 >gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sapiens] Length = 1012 Score = 111 bits (277), Expect = 1e-24 Identities = 65/171 (38%), Positives = 92/171 (53%), Gaps = 3/171 (1%) Query: 19 YDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGA 78 Y RQ+ + G A +R++ +RVL+ GL+GLGAE+AKNL+L GV LT+ D D A Sbjct: 15 YSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAA 74 Query: 79 QFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDV 138 QFL+ + R+RAEAS E LN V V V T DI E F V LT + Sbjct: 75 QFLLSEQDLERSRAEASQELLAQLNRAVQVVVHTGDI---TEDLLLDFQVVVLTAAKLEE 131 Query: 139 IVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVE 189 +KV +CHK+ + F D G G F + GE V++ T+ ++ ++ Sbjct: 132 QLKVGTLCHKHGVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPLTAAIQ 182 Score = 63.9 bits (154), Expect = 2e-10 Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 10/123 (8%) Query: 17 AQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVK-----GLTMLDHEQV 71 ++YD QI ++G Q++LR LLVG +G E+ K L G+ GLT++D + + Sbjct: 413 SRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHI 472 Query: 72 TPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-----SFFTQF 126 + QFL R+ VGR +AE + A+ LNP + V T ++ E +FF++ Sbjct: 473 ERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRV 532 Query: 127 DAV 129 D V Sbjct: 533 DGV 535 Score = 34.7 bits (78), Expect = 0.13 Identities = 12/36 (33%), Positives = 27/36 (75%) Query: 299 MAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334 ++P+ A++G + AQE++KA+S++ P + + +FD + Sbjct: 357 LSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDAL 392 >gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo sapiens] Length = 534 Score = 100 bits (248), Expect = 2e-21 Identities = 55/162 (33%), Positives = 84/162 (51%), Gaps = 3/162 (1%) Query: 18 QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPG 77 +YDRQ+RLWG Q+ L ++ V L+ G EI KNL+L G+ T++D QV+ ED G Sbjct: 12 KYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAG 71 Query: 78 AQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEKKPESFFTQFDAVCLTCC 134 F ++ S+G+NRAEA++E Q LN V V+ E++ SFF +F V T Sbjct: 72 NNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQL 131 Query: 135 SRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVE 176 +++ + + I +G GY + EH +E Sbjct: 132 PESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIE 173 Score = 48.1 bits (113), Expect = 1e-05 Identities = 44/167 (26%), Positives = 79/167 (47%), Gaps = 15/167 (8%) Query: 181 VAKVSQGVEDGPDT---KRAKLDSSETTMVKKKVVFC-PVKEALEVDW-SSEKAKAALKR 235 VAK+ Q + P++ K KL S + ++ VV C + E +D + ++ +++ Sbjct: 361 VAKLLQSIGQAPESISEKELKLLCSNSAFLR--VVRCRSLAEEYGLDTINKDEIISSMDN 418 Query: 236 TTSD---YFLLQVLLKFRTDKGRDPSSDTY--EEDSELLLQIRNDVLDSLGIS---PDLL 287 ++ Y +L+ + +F +GR P Y EED L L G+S D Sbjct: 419 PDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDY 478 Query: 288 PEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334 +F RY +E + A +GG AQE++K ++++ NN + + GM Sbjct: 479 VHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525 >gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo sapiens] Length = 528 Score = 90.5 bits (223), Expect = 2e-18 Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 3/158 (1%) Query: 22 QIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFL 81 + RLWG Q+ L ++ V L+ G EI KNL+L G+ T++D QV+ ED G F Sbjct: 10 EARLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFF 69 Query: 82 IRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEKKPESFFTQFDAVCLTCCSRDV 138 ++ S+G+NRAEA++E Q LN V V+ E++ SFF +F V T Sbjct: 70 LQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPEST 129 Query: 139 IVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVE 176 +++ + + I +G GY + EH +E Sbjct: 130 SLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIE 167 Score = 48.1 bits (113), Expect = 1e-05 Identities = 44/167 (26%), Positives = 79/167 (47%), Gaps = 15/167 (8%) Query: 181 VAKVSQGVEDGPDT---KRAKLDSSETTMVKKKVVFC-PVKEALEVDW-SSEKAKAALKR 235 VAK+ Q + P++ K KL S + ++ VV C + E +D + ++ +++ Sbjct: 355 VAKLLQSIGQAPESISEKELKLLCSNSAFLR--VVRCRSLAEEYGLDTINKDEIISSMDN 412 Query: 236 TTSD---YFLLQVLLKFRTDKGRDPSSDTY--EEDSELLLQIRNDVLDSLGIS---PDLL 287 ++ Y +L+ + +F +GR P Y EED L L G+S D Sbjct: 413 PDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDY 472 Query: 288 PEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334 +F RY +E + A +GG AQE++K ++++ NN + + GM Sbjct: 473 VHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 519 >gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] Length = 1052 Score = 86.7 bits (213), Expect = 3e-17 Identities = 60/172 (34%), Positives = 85/172 (49%), Gaps = 5/172 (2%) Query: 13 EEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVT 72 E + A Y RQ + G A +++ S V L G+ GLG EIAKNL+LAG+K +T+ D E+ Sbjct: 38 EIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQ 97 Query: 73 PEDPGAQFLIRTGSV--GRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-SFFTQFDAV 129 D G F + V RNRAEA L+ LNP V V + + + SF ++ V Sbjct: 98 AWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCV 157 Query: 130 CLTCCSRDVIVKVDQICHKN--SIKFFTGDVFGYHGYTFANLGEHEFVEEKT 179 LT + K++ C IKF + DV G F + G+ V + T Sbjct: 158 VLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTT 209 Score = 39.3 bits (90), Expect = 0.005 Identities = 34/131 (25%), Positives = 67/131 (51%), Gaps = 15/131 (11%) Query: 218 EALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVL 277 + L VD+S+ +A + + + L +F+ R P+ ++DSE LL++ + Sbjct: 310 KCLIVDFSNPEAPLEI------HTAMLALDQFQEKYSRKPNVGC-QQDSEELLKLATSIS 362 Query: 278 DSLGISPDLLPEDFVRYCF----SEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDG 333 ++L PD+ D V + ++P+ A VGG+ +QE++KA++ + P + + Sbjct: 363 ETLEEKPDV-NADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLY--- 418 Query: 334 MKGNGIVECLG 344 ++ IVE LG Sbjct: 419 LEAADIVESLG 429 Score = 39.3 bits (90), Expect = 0.005 Identities = 31/145 (21%), Positives = 59/145 (40%), Gaps = 11/145 (7%) Query: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGV-----KG-LTMLDHEQVTPEDPGAQFLIRTG 85 ++L+ + LVG +G E+ KN L GV KG +T+ D + + + QFL R Sbjct: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515 Query: 86 SVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPES-----FFTQFDAVCLTCCSRDVIV 140 + + ++ + + +N + + + E+ F+T+ D + + + Sbjct: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARR 575 Query: 141 KVDQICHKNSIKFFTGDVFGYHGYT 165 VD C N G G+T Sbjct: 576 YVDSRCLANLRPLLDSGTMGTKGHT 600 >gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] Length = 640 Score = 57.8 bits (138), Expect = 1e-08 Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 4/138 (2%) Query: 29 EAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVG 88 E + + RVL+VG G+G E+ KNL+L G + ++D + + + QFL + VG Sbjct: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVG 69 Query: 89 RNRAEASLERAQNLNPMVDVKVDTEDIEKKPE---SFFTQFDAVCLTCCSRDVIVKVDQI 145 R++A+ + E P ++ V D P+ FF QF V +R V+++ Sbjct: 70 RSKAQVAKESVLQFYPKANI-VAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRM 128 Query: 146 CHKNSIKFFTGDVFGYHG 163 C + GY G Sbjct: 129 CLAADVPLIESGTAGYLG 146 >gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] Length = 449 Score = 55.8 bits (133), Expect = 5e-08 Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%) Query: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93 L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE Sbjct: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112 Query: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140 + E + P +V I+ ++F+ QF + C D I+ Sbjct: 113 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 156 >gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] Length = 463 Score = 55.8 bits (133), Expect = 5e-08 Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%) Query: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93 L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE Sbjct: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126 Query: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140 + E + P +V I+ ++F+ QF + C D I+ Sbjct: 127 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 170 >gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] Length = 460 Score = 48.1 bits (113), Expect = 1e-05 Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 2/99 (2%) Query: 11 ISEEEAAQYDRQIRL--WGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68 +S +E +Y RQ+ L G+ Q RL + VL+VG GLG +A+ L AGV L ++D+ Sbjct: 55 LSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDY 114 Query: 69 EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD 107 + V + Q L G+ +A ++ + LN V+ Sbjct: 115 DVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVE 153 >gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo sapiens] Length = 445 Score = 48.1 bits (113), Expect = 1e-05 Identities = 44/167 (26%), Positives = 79/167 (47%), Gaps = 15/167 (8%) Query: 181 VAKVSQGVEDGPDT---KRAKLDSSETTMVKKKVVFC-PVKEALEVDW-SSEKAKAALKR 235 VAK+ Q + P++ K KL S + ++ VV C + E +D + ++ +++ Sbjct: 272 VAKLLQSIGQAPESISEKELKLLCSNSAFLR--VVRCRSLAEEYGLDTINKDEIISSMDN 329 Query: 236 TTSD---YFLLQVLLKFRTDKGRDPSSDTY--EEDSELLLQIRNDVLDSLGIS---PDLL 287 ++ Y +L+ + +F +GR P Y EED L L G+S D Sbjct: 330 PDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDY 389 Query: 288 PEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334 +F RY +E + A +GG AQE++K ++++ NN + + GM Sbjct: 390 VHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 436 >gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] Length = 623 Score = 37.0 bits (84), Expect = 0.026 Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Query: 38 RVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSV---GRNRAEA 94 + LL+G LG +A+ L+ GV+ +T +D+ +++ +P Q L G+ +A A Sbjct: 318 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 377 Query: 95 SLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFF 154 + +R Q + P V+ + I F +V L RDV +++Q+ + + F Sbjct: 378 AADRLQKIFPGVNARGFNMSIPMPGHP--VNFSSVTLEQARRDV-EQLEQLIESHDVVFL 434 Query: 155 TGD 157 D Sbjct: 435 LMD 437 >gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] Length = 676 Score = 37.0 bits (84), Expect = 0.026 Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Query: 38 RVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSV---GRNRAEA 94 + LL+G LG +A+ L+ GV+ +T +D+ +++ +P Q L G+ +A A Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416 Query: 95 SLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFF 154 + +R Q + P V+ + I F +V L RDV +++Q+ + + F Sbjct: 417 AADRLQKIFPGVNARGFNMSIPMPGHP--VNFSSVTLEQARRDV-EQLEQLIESHDVVFL 473 Query: 155 TGD 157 D Sbjct: 474 LMD 476 >gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] Length = 703 Score = 37.0 bits (84), Expect = 0.026 Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Query: 38 RVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSV---GRNRAEA 94 + LL+G LG +A+ L+ GV+ +T +D+ +++ +P Q L G+ +A A Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416 Query: 95 SLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFF 154 + +R Q + P V+ + I F +V L RDV +++Q+ + + F Sbjct: 417 AADRLQKIFPGVNARGFNMSIPMPGHP--VNFSSVTLEQARRDV-EQLEQLIESHDVVFL 473 Query: 155 TGD 157 D Sbjct: 474 LMD 476 >gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] Length = 348 Score = 34.7 bits (78), Expect = 0.13 Identities = 21/84 (25%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNR 91 +++R V +VG+ G+G+ A+ L G+ L + D+++V + F + G ++ Sbjct: 13 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSK 71 Query: 92 AEASLERAQNLNPMVDVKVDTEDI 115 +A+ +N+NP V +V +I Sbjct: 72 VQAAEHTLRNINPDVLFEVHNYNI 95 >gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] Length = 404 Score = 34.7 bits (78), Expect = 0.13 Identities = 21/84 (25%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNR 91 +++R V +VG+ G+G+ A+ L G+ L + D+++V + F + G ++ Sbjct: 69 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSK 127 Query: 92 AEASLERAQNLNPMVDVKVDTEDI 115 +A+ +N+NP V +V +I Sbjct: 128 VQAAEHTLRNINPDVLFEVHNYNI 151 >gi|193788653 hypothetical protein LOC100131897 [Homo sapiens] Length = 535 Score = 30.8 bits (68), Expect = 1.9 Identities = 24/69 (34%), Positives = 34/69 (49%), Gaps = 4/69 (5%) Query: 168 NLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEV-DWSS 226 NL E + V +++Q +EDGP +R K+ + V K PV LE W S Sbjct: 137 NLSEQDIVSSDLAYLRLAQHLEDGP--RRVKVSHAFLPRVPKVQSNGPVSICLEAGTWRS 194 Query: 227 -EKAKAALK 234 EKA AA++ Sbjct: 195 LEKATAAIQ 203 >gi|109809739 La ribonucleoprotein domain family, member 7 [Homo sapiens] Length = 582 Score = 29.6 bits (65), Expect = 4.1 Identities = 25/91 (27%), Positives = 41/91 (45%), Gaps = 3/91 (3%) Query: 175 VEEKTKVAKVSQGV--EDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAA 232 VEEK K K + ED K +D+S T++ K K P E +++ + + + + Sbjct: 215 VEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMK-RSRPTSEGSDIESTEPQKQCS 273 Query: 233 LKRTTSDYFLLQVLLKFRTDKGRDPSSDTYE 263 K+ D L + RT K + SS+ E Sbjct: 274 KKKKKRDRVEASSLPEVRTGKRKRSSSEDAE 304 >gi|109809741 La ribonucleoprotein domain family, member 7 [Homo sapiens] Length = 582 Score = 29.6 bits (65), Expect = 4.1 Identities = 25/91 (27%), Positives = 41/91 (45%), Gaps = 3/91 (3%) Query: 175 VEEKTKVAKVSQGV--EDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAA 232 VEEK K K + ED K +D+S T++ K K P E +++ + + + + Sbjct: 215 VEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMK-RSRPTSEGSDIESTEPQKQCS 273 Query: 233 LKRTTSDYFLLQVLLKFRTDKGRDPSSDTYE 263 K+ D L + RT K + SS+ E Sbjct: 274 KKKKKRDRVEASSLPEVRTGKRKRSSSEDAE 304 >gi|189027141 abhydrolase domain containing 6 [Homo sapiens] Length = 337 Score = 28.5 bits (62), Expect = 9.2 Identities = 19/77 (24%), Positives = 39/77 (50%), Gaps = 10/77 (12%) Query: 257 PSSDTYEEDSELLLQIR----NDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQ 312 P+ Y D++ + +++ + ++ + + P PE+ SEM +C+ V + Q Sbjct: 173 PAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPST-PEEM-----SEMLQLCSYVRFKVPQ 226 Query: 313 EIVKALSQRDPPHNNFF 329 +I++ L PHNNF+ Sbjct: 227 QILQGLVDVRIPHNNFY 243 >gi|104526627 triadin [Homo sapiens] Length = 729 Score = 28.5 bits (62), Expect = 9.2 Identities = 14/36 (38%), Positives = 23/36 (63%) Query: 175 VEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKK 210 V + K A+VS+ VED P +K+AK + + + K+K Sbjct: 648 VTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683 >gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens] Length = 1626 Score = 28.5 bits (62), Expect = 9.2 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 2/66 (3%) Query: 256 DPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIV 315 D SS +ED E + Q +++D+ + PD VRY S+ +G +QE V Sbjct: 44 DTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRY--SDRPTTAFELGLFGSQEEV 101 Query: 316 KALSQR 321 KA ++R Sbjct: 102 KAAARR 107 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.136 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,878,216 Number of Sequences: 37866 Number of extensions: 540967 Number of successful extensions: 1532 Number of sequences better than 10.0: 26 Number of HSP's better than 10.0 without gapping: 19 Number of HSP's successfully gapped in prelim test: 7 Number of HSP's that attempted gapping in prelim test: 1489 Number of HSP's gapped (non-prelim): 40 length of query: 346 length of database: 18,247,518 effective HSP length: 103 effective length of query: 243 effective length of database: 14,347,320 effective search space: 3486398760 effective search space used: 3486398760 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.