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Search of human proteins with 4826784
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826784 potassium voltage-gated channel, Shab-related
subfamily, member 1 [Homo sapiens]
(858 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826784 potassium voltage-gated channel, Shab-related subfami... 1716 0.0
gi|27436974 potassium voltage-gated channel, Shab-related subfam... 1022 0.0
gi|25952108 potassium voltage-gated channel delayed-rectifier pr... 398 e-110
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens] 377 e-104
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ... 375 e-104
gi|20070166 potassium voltage-gated channel, subfamily F, member... 366 e-101
gi|13492973 potassium voltage-gated channel delayed-rectifier pr... 357 3e-98
gi|27436988 potassium voltage-gated channel, subfamily G, member... 356 4e-98
gi|27436996 potassium voltage-gated channel, subfamily G, member... 336 5e-92
gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens] 332 9e-91
gi|6912444 potassium voltage-gated channel, subfamily G, member ... 315 9e-86
gi|27436993 potassium voltage-gated channel, subfamily G, member... 300 5e-81
gi|88758576 Shaw-related voltage-gated potassium channel protein... 299 8e-81
gi|24497462 Shaw-related voltage-gated potassium channel protein... 299 8e-81
gi|24497464 Shaw-related voltage-gated potassium channel protein... 299 8e-81
gi|19071574 potassium voltage-gated channel, subfamily G, member... 296 4e-80
gi|4826786 Shaw-related voltage-gated potassium channel protein ... 296 5e-80
gi|163792201 Shaw-related voltage-gated potassium channel protei... 296 5e-80
gi|21217561 Shaw-related voltage-gated potassium channel protein... 293 5e-79
gi|21217563 Shaw-related voltage-gated potassium channel protein... 293 5e-79
gi|24497458 Shaw-related voltage-gated potassium channel protein... 293 5e-79
gi|119395748 potassium voltage-gated channel subfamily A member ... 280 3e-75
gi|9789987 potassium voltage-gated channel, Shal-related subfami... 280 4e-75
gi|27436981 potassium voltage-gated channel, Shal-related subfam... 279 9e-75
gi|4826782 potassium voltage-gated channel, shaker-related subfa... 278 2e-74
gi|27436986 potassium voltage-gated channel, Shal-related subfam... 271 2e-72
gi|5031819 potassium voltage-gated channel, shaker-related subfa... 270 3e-72
gi|27436984 potassium voltage-gated channel, Shal-related subfam... 270 4e-72
gi|4504817 potassium voltage-gated channel, shaker-related subfa... 270 5e-72
gi|88758565 potassium voltage-gated channel, shaker-related subf... 268 1e-71
>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
member 1 [Homo sapiens]
Length = 858
Score = 1716 bits (4445), Expect = 0.0
Identities = 858/858 (100%), Positives = 858/858 (100%)
Query: 1 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL 60
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL
Sbjct: 1 MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL 60
Query: 61 RDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD 120
RDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD
Sbjct: 61 RDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD 120
Query: 121 YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE 180
YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
Sbjct: 121 YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE 180
Query: 181 KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF 240
KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF
Sbjct: 181 KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF 240
Query: 241 TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR 300
TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR
Sbjct: 241 TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR 300
Query: 301 IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK 360
IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK
Sbjct: 301 IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK 360
Query: 361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY 420
FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY
Sbjct: 361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY 420
Query: 421 KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQD 480
KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQD
Sbjct: 421 KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQD 480
Query: 481 NHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQ 540
NHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQ
Sbjct: 481 NHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQ 540
Query: 541 SQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPE 600
SQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPE
Sbjct: 541 SQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPE 600
Query: 601 ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSS 660
ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSS
Sbjct: 601 ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSS 660
Query: 661 MKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLS 720
MKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLS
Sbjct: 661 MKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLS 720
Query: 721 PESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPG 780
PESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPG
Sbjct: 721 PESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPG 780
Query: 781 STSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD 840
STSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD
Sbjct: 781 STSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD 840
Query: 841 VRVLPGGGAHGSTRDQSI 858
VRVLPGGGAHGSTRDQSI
Sbjct: 841 VRVLPGGGAHGSTRDQSI 858
>gi|27436974 potassium voltage-gated channel, Shab-related
subfamily, member 2 [Homo sapiens]
Length = 911
Score = 1022 bits (2643), Expect = 0.0
Identities = 577/915 (63%), Positives = 656/915 (71%), Gaps = 67/915 (7%)
Query: 2 PAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLR 61
P G+ + SRST SLPPEP++I+RSK CSRRV++NVGGL HEVLWRTLDRLPRTRLGKLR
Sbjct: 6 PPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR 65
Query: 62 DCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDY 121
DCNTH+SLLEVCDDY+L++NEYFFDRHPGAFTSILNFYRTG+LHMMEEMCALSF QELDY
Sbjct: 66 DCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDY 125
Query: 122 WGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEK 181
WGIDEIYLESCCQARYHQKKEQMNEEL+REAET+REREGEEFDNTCC +KRKKLWDLLEK
Sbjct: 126 WGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEK 185
Query: 182 PNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFT 241
PNSSVAAKILAI+SI+FIVLSTIALSLNTLPELQ DEFGQ DN QLAHVEAVCIAWFT
Sbjct: 186 PNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFT 245
Query: 242 MEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRI 301
MEYLLRFLSSP KWKFFKGPLN IDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRI
Sbjct: 246 MEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRI 305
Query: 302 MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKF 361
MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDED TKF
Sbjct: 306 MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKF 365
Query: 362 KSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYK 421
SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYK
Sbjct: 366 TSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYK 425
Query: 422 EQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDN 481
EQKRQEKAIKRREALERAKRNGSIVSMN+KDAFARS+E++D+ VEK GE+ KD DN
Sbjct: 426 EQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDN 485
Query: 482 HLSPNKWKWTKRTLSETSSSKSFETKEQGSPEK-------ARSSSSPQHLNVQQLEDMYN 534
HLSP++WKW ++ LSETSS+KSFE K Q +K SSSSPQHL+ Q+LE +YN
Sbjct: 486 HLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYN 545
Query: 535 KMAKTQ--SQPILNTKESAAQ-SKPKEELEMESIPSPVAPLP-TRTEGVIDMRSMSSIDS 590
++ KTQ S P + +E + S +EE+EME + P L +TE ++DM+S SSIDS
Sbjct: 546 EITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDS 605
Query: 591 FISCATDFPEATRFSHSPL-------------TSLPSKTGGSTA---------PEVGWRG 628
F SCATDF E R SPL T LP A E G
Sbjct: 606 FTSCATDFTETER---SPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAA 662
Query: 629 ALGASGGRFVEANPSPDAS---------QHSSFFIESPKSSMKTNNPLKLRALKVNFMEG 679
G V+ + DAS S +SPKSS+K +NPLK R+LKVNF E
Sbjct: 663 RDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKEN 722
Query: 680 -------DPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAK 732
PS P+ D + + E + D+ +L E S +K
Sbjct: 723 RGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSK 782
Query: 733 -TPPRSPEKHTAIAFNFEAGVHQ-YIDADTDDEGQLLYSVDSSPPK---SLPGSTSPKFS 787
PR P++ F F + + + + DT D+ L + K S P + K S
Sbjct: 783 GLSPRFPKQK---LFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPS 839
Query: 788 TG---TRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHI-SPDVRV 843
G R E + SSP T RQ+ ++ + K S QE CK+ENH+ +P++
Sbjct: 840 DGRDPLREEGSVGSSSPQDTGHN-CRQDIYHAVSEV--KKDSSQEGCKMENHLFAPEIHS 896
Query: 844 LPGGGAHGSTRDQSI 858
PG + TR+ S+
Sbjct: 897 NPGDTGYCPTRETSM 911
>gi|25952108 potassium voltage-gated channel delayed-rectifier
protein S3 [Homo sapiens]
Length = 491
Score = 398 bits (1022), Expect = e-110
Identities = 201/467 (43%), Positives = 298/467 (63%), Gaps = 18/467 (3%)
Query: 33 VRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAF 92
V LNVGG V TL R P TRLGKL C++ +++LE+CDDYS+ D EY+FDR+P F
Sbjct: 17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLF 76
Query: 93 TSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNE------ 146
+LNFY TG+LH+MEE+C SF QE++YWGI+E++++SCC RY ++KE+ +E
Sbjct: 77 RYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQK 136
Query: 147 ------ELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIV 200
+ E +L E+E E+FD + RKK+W +E P ++AK++AI S+ ++
Sbjct: 137 SHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVL 196
Query: 201 LSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKG 260
S +A+ ++++ E Q+ D D+P L VE CIAWFT E +R ++P + KF+K
Sbjct: 197 ASIVAMCVHSMSEFQNEDG---EVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKN 253
Query: 261 PLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSL 320
PLN ID ++I+P+Y T+ + + +N+ +VVQI R+MRI RILKLARHS GL+SL
Sbjct: 254 PLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSL 313
Query: 321 GFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGY 380
G TLR SY+E+GLL+LFL++GI IFS L++ EKD+ + SIP +WWATI+MTTVGY
Sbjct: 314 GATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGY 373
Query: 381 GDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAK 440
GD +P TL GK++ C I G+LV+ALPI II N FS++Y++QK + +A E+
Sbjct: 374 GDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCH 433
Query: 441 RNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNK 487
+ N++D +A+ + + G + D + + N+
Sbjct: 434 ---ELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNE 477
>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
Length = 500
Score = 377 bits (968), Expect = e-104
Identities = 206/446 (46%), Positives = 293/446 (65%), Gaps = 28/446 (6%)
Query: 35 LNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTH----------DSLLEVCDDYSLDDNEYF 84
+NVGG + + L P TRLGKL S LE+CDD + DNEYF
Sbjct: 43 VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102
Query: 85 FDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQM 144
FDR AF +L++YRTGRLH+ME++CALSF QE+ YWGIDE+ ++SCC+ RY ++KE
Sbjct: 103 FDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELS 162
Query: 145 NE-ELKREAETLREREGEE--FDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVL 201
+ K++ E + E F C R+KLW++LEKP SS AA+I +ISI+F+V+
Sbjct: 163 ETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVV 222
Query: 202 STIALSLNTLPELQSLDEFGQSTDNPQLAHV-EAVCIAWFTMEYLLRFLSSPKKWKFFKG 260
S I ++L + EL LD QL + E VCI+WFT E++LRFL + +F +
Sbjct: 223 SIINMALMSA-ELSWLDL--------QLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRK 273
Query: 261 PLNAIDLLAILPYYVTIFLTE--SNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQ 318
N IDLLAILP+Y+T+ + +++ + +NV R+VQ+ R++R LR+LKL RHSTGL+
Sbjct: 274 VPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLR 333
Query: 319 SLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTV 378
SLG T+ + Y E+GLL+LFL++GI IFS++ +FAE+ DT F S+P ++WWAT +MTTV
Sbjct: 334 SLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTTV 393
Query: 379 GYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALER 438
GYGDI P T GKIV +C ++G+LV+ALPI II + FS Y K +E A+++REAL++
Sbjct: 394 GYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKK 453
Query: 439 AKRN---GSIVSMNMKDAFARSIEMM 461
+N S +S+N++D +ARSI M
Sbjct: 454 LTKNIATDSYISVNLRDVYARSIMEM 479
>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
subfamily S, member 2 [Homo sapiens]
Length = 477
Score = 375 bits (964), Expect = e-104
Identities = 188/441 (42%), Positives = 285/441 (64%), Gaps = 16/441 (3%)
Query: 33 VRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAF 92
+R+NVGG + TL R P TRLG+L C++ +++LE+CDDY E++FDR+P F
Sbjct: 19 IRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78
Query: 93 TSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKK-----EQMNEE 147
+L+FY TG+LH+M E+C SFSQE++YWGI+E +++SCC YH +K E+ +E+
Sbjct: 79 PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQ 138
Query: 148 LKREAETLRERE-------GEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIV 200
+E+ T E +FD R++LW L+ P SV +++ +I+SI+ ++
Sbjct: 139 SDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVM 198
Query: 201 LSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKG 260
S I + LN+LP+ Q D G ++P+ VE IAWFT E + RF +P KFFK
Sbjct: 199 GSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKN 258
Query: 261 PLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSL 320
LN IDL++I+P+Y+T+ + +S N+ RV Q+ R+MRI RILKLARHSTGL+SL
Sbjct: 259 ALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSL 318
Query: 321 GFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGY 380
G TL+ SY E+GLL+L+L++GI IFS + + EK+E++ +IPA +WWAT++MTTVGY
Sbjct: 319 GATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENE-GLATIPACWWWATVSMTTVGY 377
Query: 381 GDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAK 440
GD+ P T GK+ C +AG+LV+ LPI +I N FS FY+ QK+ E A++ + + K
Sbjct: 378 GDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMK 437
Query: 441 RNGSIVSMNMKDAFARSIEMM 461
+ S+N++D +A ++ +
Sbjct: 438 ---EVPSVNLRDYYAHKVKSL 455
>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
[Homo sapiens]
Length = 494
Score = 366 bits (939), Expect = e-101
Identities = 182/429 (42%), Positives = 272/429 (63%), Gaps = 5/429 (1%)
Query: 18 PEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDC--NTHDSLLEVCDD 75
PEP + + + +NVGG+ + L + P TRL +L +C +D++ +CDD
Sbjct: 10 PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDD 69
Query: 76 YSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQA 135
Y E++FDR P AF ++ Y G +HM + +C + F E+D+W +D +L+ CC++
Sbjct: 70 YDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKS 129
Query: 136 RYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIIS 195
+K+E++ EE+ R + + + G + +K +W LEKP SS A+++A++S
Sbjct: 130 HLSEKREEL-EEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLS 188
Query: 196 IMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKW 255
+ I++S++ + + T+PELQ LD G ++P L +VE CI WFT+EYLLR SSP K
Sbjct: 189 FLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKL 248
Query: 256 KFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHST 315
F +N +D+LAILP+YV++ LT +++ NV++ VQ RIMRI RI KLARHS+
Sbjct: 249 HFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSS 308
Query: 316 GLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITM 375
GLQ+L + L+RS+ ELGLL+++LA+GI +FS+L + E+ +T FKSIP SFWWA ITM
Sbjct: 309 GLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITM 368
Query: 376 TTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREA 435
TTVGYGDIYPKT LGK+ + + GV+ IALPI I+NNF +Y +Q+ E A K
Sbjct: 369 TTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHE-- 426
Query: 436 LERAKRNGS 444
LE + N S
Sbjct: 427 LELMELNSS 435
>gi|13492973 potassium voltage-gated channel delayed-rectifier
protein S1 [Homo sapiens]
Length = 526
Score = 357 bits (915), Expect = 3e-98
Identities = 183/455 (40%), Positives = 279/455 (61%), Gaps = 30/455 (6%)
Query: 6 TKHGSRSTSSLP---PEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRD 62
T G RST + P P +R + +R+NVGG+ ++ R L R P TRLG+L+
Sbjct: 22 TPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQA 81
Query: 63 CNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYW 122
+ + +CDDY E++FDRHPG F S+L+FYRTG LH+++E+C +F QE DYW
Sbjct: 82 AASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYW 141
Query: 123 GIDEIYLESCCQARYHQKKEQMNEELKREAETLR------------EREGEEFDNTCCAE 170
G+ E L +CC+ARY +++ +++T +RE + C
Sbjct: 142 GLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGR 201
Query: 171 KRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLD--------EFGQ 222
R++LW +E P S+ +K+ + +SI ++ S A+ +++LPE Q+ + G+
Sbjct: 202 LRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGR 261
Query: 223 S----TDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIF 278
S D+P L +E CIAWF+ E R L +P FF PLN ID++++LP+Y+T+
Sbjct: 262 SPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLL 321
Query: 279 --LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLIL 336
+ ++ +F ++ +VVQ+FR+MRI R+LKLARHSTGL+SLG TL+ SY E+G+L+L
Sbjct: 322 AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL 381
Query: 337 FLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGL 396
+LA+G+ +FS + + AEK E+D F +IPA +WW T++MTTVGYGD+ P T+ GK+
Sbjct: 382 YLAVGVSVFSGVAYTAEK-EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASG 440
Query: 397 CCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIK 431
C + G+LV+ALPI II N FS FY+ QK E A++
Sbjct: 441 CILGGILVVALPITIIFNKFSHFYRRQKALEAAVR 475
>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
[Homo sapiens]
Length = 513
Score = 356 bits (914), Expect = 4e-98
Identities = 180/435 (41%), Positives = 277/435 (63%), Gaps = 21/435 (4%)
Query: 19 EPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSL 78
EP + + + RR+ +NVGG+ + + W TLD P TRLG+L+ C D +L VCDDY +
Sbjct: 51 EPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDV 110
Query: 79 DDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYH 138
NE+FFDR+PGAF +IL F R G+L ++ EMCALSF +EL YWGI E +L+ CC+ RY
Sbjct: 111 TCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYL 170
Query: 139 QKKEQMNEELKREAE-TLREREGEEFDNTCCAEKR-----KKLWDLLEKPNSSVAAKILA 192
QK E+ E ++RE E + EG + + E R ++L D++E+P+S + K+ A
Sbjct: 171 QKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFA 230
Query: 193 IISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAH----VEAVCIAWFTMEYLLRF 248
+S++F+ ++ + LS++TLP L+ +E G + Q+ H VE+VC+ WF++E+LLR
Sbjct: 231 CLSVLFVTVTAVNLSVSTLPSLREEEEQGHCS---QMCHNVFIVESVCVGWFSLEFLLRL 287
Query: 249 LSSPKKWKFFKGPLNAIDLLAILPYYVTIFL-------TESNKSVLQFQNVRRVVQIFRI 301
+ +P K+ F + PL IDL+AILPYY+T+ + + V V+++ R
Sbjct: 288 IQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRA 347
Query: 302 MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKD-EDDTK 360
+RIL +++LARHS GLQ+LG T RR E GLL+LFL + I +F+ L++ E + D +
Sbjct: 348 LRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPE 407
Query: 361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY 420
F SIPA +WWA ITMTTVGYGD+ P++ G++V ++G+L++A P+ I + FS Y
Sbjct: 408 FTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSY 467
Query: 421 KEQKRQEKAIKRREA 435
E K++++ + R A
Sbjct: 468 LELKQEQERVMFRRA 482
>gi|27436996 potassium voltage-gated channel, subfamily G, member 4
[Homo sapiens]
Length = 519
Score = 336 bits (862), Expect = 5e-92
Identities = 172/438 (39%), Positives = 280/438 (63%), Gaps = 23/438 (5%)
Query: 11 RSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLL 70
R +L P+++ + + +NVGG + + W TLDR P +RL KLR C +++ ++
Sbjct: 45 RKVGALDASPVDL------KKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIV 98
Query: 71 EVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLE 130
++CDDY D E+FFDR P AF I++F G+L +++EMCALSF +EL YWGI+E +LE
Sbjct: 99 QLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLE 158
Query: 131 SCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEK----RKKLWDLLEKPNSSV 186
CC + +K E++ E K E + ++ E + + +L +++E P S +
Sbjct: 159 RCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGL 218
Query: 187 AAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQ-STDNPQLAHVEAVCIAWFTMEYL 245
K+ A +SI+F+ + ++L ++T+P+L++ ++ G+ S + VE +C+AWF++E+
Sbjct: 219 PGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFC 278
Query: 246 LRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTE---------SNKSVLQFQNVRRVV 296
LRF+ + K +FF+GPLN ID+LAI PYYV++ ++E S S L + V V+
Sbjct: 279 LRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYL--EKVGLVL 336
Query: 297 QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE 356
++ R +RIL +++LARHS GLQ+LG T+RR E GLL+LFLA+ I +FS LV+ AEK+
Sbjct: 337 RVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKES 396
Query: 357 DDT-KFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNN 415
+F SIPAS+WWA I+MTTVGYGD+ P+++ G++V ++G+L++A P I +
Sbjct: 397 GRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHT 456
Query: 416 FSEFYKEQKRQEKAIKRR 433
FS Y E K++++ ++ R
Sbjct: 457 FSHSYLELKKEQEQLQAR 474
>gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]
Length = 545
Score = 332 bits (851), Expect = 9e-91
Identities = 168/416 (40%), Positives = 261/416 (62%), Gaps = 14/416 (3%)
Query: 33 VRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAF 92
+ +NVGG ++++ + L P+TRLG+L + L +CDDY +EYFFDR P F
Sbjct: 99 LNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVF 158
Query: 93 TSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREA 152
+ NFY +G L +++ +C F +EL YWG+ Y CC+ + +++++++E LK +
Sbjct: 159 QLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQH 218
Query: 153 ETLREREGEEF-----DNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALS 207
E + + EE D +R++LW+L+EKP SSVAAK + + S F+++S +AL+
Sbjct: 219 ELRAQAQVEEAEELFRDMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALA 278
Query: 208 LNTLPELQSLDEFGQSTDN--PQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAI 265
LNT+ E+Q G+ + P L HVE +C+ +FT+EYLLR S+P +F + LN +
Sbjct: 279 LNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLV 338
Query: 266 DLLAILPYYVTIFLT-------ESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQ 318
DL+AILP Y+ + L + ++V V +V+++ R+MRI RILKLARHSTGL+
Sbjct: 339 DLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLR 398
Query: 319 SLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTV 378
+ GFTLR+ Y ++G L+LF+AMGI FS+ V+ E D T F +IP S+WWA ++++TV
Sbjct: 399 AFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTV 458
Query: 379 GYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 434
GYGD+YP+T LG+ LC G+++ +PI I+ N FS++Y + K E RRE
Sbjct: 459 GYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRE 514
>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
[Homo sapiens]
Length = 466
Score = 315 bits (808), Expect = 9e-86
Identities = 163/407 (40%), Positives = 250/407 (61%), Gaps = 10/407 (2%)
Query: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHP 89
+R V +NVGG + W L R P RL +LR C HD LL VCDDY + +E+FFDR P
Sbjct: 16 ARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYDVSRDEFFFDRSP 75
Query: 90 GAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELK 149
AF +I+ R G+L ++ CAL+F EL YWGIDE LE CC R +++E+ E
Sbjct: 76 CAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAE--A 133
Query: 150 REAETLREREGEEF----DNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIA 205
R T R +G R++L D+++ P+S +A K+ A +S+ F+ ++ +
Sbjct: 134 RAGPTERGAQGSPARALGPRGRLQRGRRRLRDVVDNPHSGLAGKLFACVSVSFVAVTAVG 193
Query: 206 LSLNTLPELQSLDEFGQ-STDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNA 264
L L+T+P++++ +E G+ S L +E VC+AWF+ E+LLR L + K F + PLN
Sbjct: 194 LCLSTMPDIRAEEERGECSPKCRSLFVLETVCVAWFSFEFLLRSLQAESKCAFLRAPLNI 253
Query: 265 IDLLAILPYYVTIF--LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGF 322
ID+LA+LP+YV++ L + V+++ R +R+L +++LARHS GL+SLG
Sbjct: 254 IDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGL 313
Query: 323 TLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK-FKSIPASFWWATITMTTVGYG 381
T+RR E GLL+LFL + + +F+ LV AE++ + F S+PAS+WWA I+MTTVGYG
Sbjct: 314 TMRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVISMTTVGYG 373
Query: 382 DIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 428
D+ P++L G++V ++G+L++A P+ I + FS Y E K Q++
Sbjct: 374 DMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQ 420
>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
isoform 2 [Homo sapiens]
Length = 425
Score = 300 bits (767), Expect = 5e-81
Identities = 167/425 (39%), Positives = 247/425 (58%), Gaps = 11/425 (2%)
Query: 21 MEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDD 80
M RS A S V LNVGG + + L P R+ +L C + +LEVCDDY +
Sbjct: 1 MTFGRSGAAS--VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRER 58
Query: 81 NEYFFDRHPGAFTSILNFYRT-GRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQ 139
NEYFFDRH AF IL + R G+L MC LSF E+ YWG++ +LE CCQ R
Sbjct: 59 NEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDD 118
Query: 140 KKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDL---LEKPNSSVAAKILAIISI 196
+ + + R+ A R+ L + E+P SS+AA+ILA +S+
Sbjct: 119 RMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSV 178
Query: 197 MFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWK 256
+F+++S + L +TLP+ ++ +S D+ +EA+CI WFT E ++RF+ S K +
Sbjct: 179 VFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRI-IEAICIGWFTAECIVRFIVSKNKCE 237
Query: 257 FFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTG 316
F K PLN IDLLAI PYY+++ +T Q Q +++ R+MRI ++KLARH G
Sbjct: 238 FVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIG 297
Query: 317 LQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDED----DTKFKSIPASFWWAT 372
LQ+LG TL+R Y E+ +L++F+ + + IFS+L E D + F SIPA+ WW
Sbjct: 298 LQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVI 357
Query: 373 ITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKR 432
I+MTTVGYGD+YP T+ G+I+GG+C ++G++++ALPI I ++F + Y E K + R
Sbjct: 358 ISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSR 417
Query: 433 REALE 437
+ E
Sbjct: 418 SLSTE 422
>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
isoform c [Homo sapiens]
Length = 626
Score = 299 bits (765), Expect = 8e-81
Identities = 177/490 (36%), Positives = 261/490 (53%), Gaps = 63/490 (12%)
Query: 5 MTKHGSRSTSSLPPEPM----EIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL 60
++ + R + + PP E+ + +A S ++ +NVGG HE TL LP TRL L
Sbjct: 7 VSSYRGRKSGNKPPSKTCLKEEMAKGEA-SEKIIINVGGTRHETYRSTLRTLPGTRLAWL 65
Query: 61 RDCN------THDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALS 114
D + T + E+FFDRHPG F +LN+YRTG+LH ++C
Sbjct: 66 ADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPL 125
Query: 115 FSQELDYWGIDEIYLESCCQARYHQKK-----------------------EQMNEELKRE 151
F +EL +WGIDE +E CC Y Q + E ++E +
Sbjct: 126 FEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELA 185
Query: 152 AETLREREG---EEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSL 208
+ L EG + C + ++W L E P SS AA+++A S+ FI++S L
Sbjct: 186 LQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCL 245
Query: 209 NT---------------LPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPK 253
T + + S+ + P L ++E VC+ WFT+E+L+R + P
Sbjct: 246 ETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPD 305
Query: 254 KWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARH 313
F K LN ID +AILP+Y+ + L S S ++V +++ R +RILRI KL RH
Sbjct: 306 TLDFVKNLLNIIDFVAILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRH 363
Query: 314 STGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFKSI 364
GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ D T FK+I
Sbjct: 364 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNI 423
Query: 365 PASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQK 424
P FWWA +TMTT+GYGD+YPKT G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 424 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 483
Query: 425 RQEKAIKRRE 434
++K K+R+
Sbjct: 484 AKQKLPKKRK 493
>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
isoform a [Homo sapiens]
Length = 635
Score = 299 bits (765), Expect = 8e-81
Identities = 177/490 (36%), Positives = 261/490 (53%), Gaps = 63/490 (12%)
Query: 5 MTKHGSRSTSSLPPEPM----EIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL 60
++ + R + + PP E+ + +A S ++ +NVGG HE TL LP TRL L
Sbjct: 7 VSSYRGRKSGNKPPSKTCLKEEMAKGEA-SEKIIINVGGTRHETYRSTLRTLPGTRLAWL 65
Query: 61 RDCN------THDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALS 114
D + T + E+FFDRHPG F +LN+YRTG+LH ++C
Sbjct: 66 ADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPL 125
Query: 115 FSQELDYWGIDEIYLESCCQARYHQKK-----------------------EQMNEELKRE 151
F +EL +WGIDE +E CC Y Q + E ++E +
Sbjct: 126 FEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELA 185
Query: 152 AETLREREG---EEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSL 208
+ L EG + C + ++W L E P SS AA+++A S+ FI++S L
Sbjct: 186 LQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCL 245
Query: 209 NT---------------LPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPK 253
T + + S+ + P L ++E VC+ WFT+E+L+R + P
Sbjct: 246 ETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPD 305
Query: 254 KWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARH 313
F K LN ID +AILP+Y+ + L S S ++V +++ R +RILRI KL RH
Sbjct: 306 TLDFVKNLLNIIDFVAILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRH 363
Query: 314 STGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFKSI 364
GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ D T FK+I
Sbjct: 364 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNI 423
Query: 365 PASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQK 424
P FWWA +TMTT+GYGD+YPKT G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 424 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 483
Query: 425 RQEKAIKRRE 434
++K K+R+
Sbjct: 484 AKQKLPKKRK 493
>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
isoform b [Homo sapiens]
Length = 582
Score = 299 bits (765), Expect = 8e-81
Identities = 177/490 (36%), Positives = 261/490 (53%), Gaps = 63/490 (12%)
Query: 5 MTKHGSRSTSSLPPEPM----EIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL 60
++ + R + + PP E+ + +A S ++ +NVGG HE TL LP TRL L
Sbjct: 7 VSSYRGRKSGNKPPSKTCLKEEMAKGEA-SEKIIINVGGTRHETYRSTLRTLPGTRLAWL 65
Query: 61 RDCN------THDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALS 114
D + T + E+FFDRHPG F +LN+YRTG+LH ++C
Sbjct: 66 ADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPL 125
Query: 115 FSQELDYWGIDEIYLESCCQARYHQKK-----------------------EQMNEELKRE 151
F +EL +WGIDE +E CC Y Q + E ++E +
Sbjct: 126 FEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELA 185
Query: 152 AETLREREG---EEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSL 208
+ L EG + C + ++W L E P SS AA+++A S+ FI++S L
Sbjct: 186 LQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCL 245
Query: 209 NT---------------LPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPK 253
T + + S+ + P L ++E VC+ WFT+E+L+R + P
Sbjct: 246 ETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPD 305
Query: 254 KWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARH 313
F K LN ID +AILP+Y+ + L S S ++V +++ R +RILRI KL RH
Sbjct: 306 TLDFVKNLLNIIDFVAILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRH 363
Query: 314 STGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFKSI 364
GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ D T FK+I
Sbjct: 364 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNI 423
Query: 365 PASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQK 424
P FWWA +TMTT+GYGD+YPKT G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 424 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 483
Query: 425 RQEKAIKRRE 434
++K K+R+
Sbjct: 484 AKQKLPKKRK 493
>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
isoform 1 [Homo sapiens]
Length = 436
Score = 296 bits (759), Expect = 4e-80
Identities = 169/435 (38%), Positives = 249/435 (57%), Gaps = 20/435 (4%)
Query: 21 MEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDD 80
M RS A S V LNVGG + + L P R+ +L C + +LEVCDDY +
Sbjct: 1 MTFGRSGAAS--VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRER 58
Query: 81 NEYFFDRHPGAFTSILNFYRT-GRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQ 139
NEYFFDRH AF IL + R G+L MC LSF E+ YWG++ +LE CCQ R
Sbjct: 59 NEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDD 118
Query: 140 KKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDL---LEKPNSSVAAKILAIISI 196
+ + + R+ A R+ L + E+P SS+AA+ILA +S+
Sbjct: 119 RMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSV 178
Query: 197 MFIVLSTIALSLNTLPELQ-------SLDEFGQSTDNP---QLAHVEAVCIAWFTMEYLL 246
+F+++S + L +TLP+ + SLD+ + + P +EA+CI WFT E ++
Sbjct: 179 VFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIV 238
Query: 247 RFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILR 306
RF+ S K +F K PLN IDLLAI PYY+++ +T Q Q +++ R+MRI
Sbjct: 239 RFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFW 298
Query: 307 ILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDED----DTKFK 362
++KLARH GLQ+LG TL+R Y E+ +L++F+ + + IFS+L E D + F
Sbjct: 299 VIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFT 358
Query: 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 422
SIPA+ WW I+MTTVGYGD+YP T+ G+I+GG+C ++G++++ALPI I ++F + Y E
Sbjct: 359 SIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHE 418
Query: 423 QKRQEKAIKRREALE 437
K + R + E
Sbjct: 419 LKFRSARYSRSLSTE 433
>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
isoform B [Homo sapiens]
Length = 511
Score = 296 bits (758), Expect = 5e-80
Identities = 170/458 (37%), Positives = 249/458 (54%), Gaps = 60/458 (13%)
Query: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHP 89
S R+ +NVGG H+ TL LP TRL L + + H DY +E+FFDRHP
Sbjct: 7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHP 61
Query: 90 GAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNE--- 146
G F ILN+YRTG+LH ++C + +EL +WGIDE +E CC Y Q ++
Sbjct: 62 GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDS 121
Query: 147 ----ELKREAETL-REREGEEFDNTCCAEKRKKL---------------------WDLLE 180
L A+ + G+ D E K+L W L E
Sbjct: 122 FGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFE 181
Query: 181 KPNSSVAAKILAIISIMFIVLSTIALSLNT---------LPELQSLDE------FGQSTD 225
P SS A+ +A S+ FI++S L T E++++ + ++
Sbjct: 182 DPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAET 241
Query: 226 NPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKS 285
L ++E VC+ WFT E+L+R + P K +F K LN ID +AILP+Y+ + L S S
Sbjct: 242 EAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGL--SGLS 299
Query: 286 VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIF 345
++V +++ R +RILRI KL RH GL+ LG TLR S NE LLI+FLA+G++IF
Sbjct: 300 SKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 359
Query: 346 SSLVFFAEK---------DEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGL 396
++++++AE+ + T FK+IP FWWA +TMTT+GYGD+YP+T G +VG L
Sbjct: 360 ATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL 419
Query: 397 CCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 434
C +AGVL IA+P+P+IVNNF +Y ++K K+++
Sbjct: 420 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKK 457
>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
isoform A [Homo sapiens]
Length = 585
Score = 296 bits (758), Expect = 5e-80
Identities = 170/458 (37%), Positives = 249/458 (54%), Gaps = 60/458 (13%)
Query: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHP 89
S R+ +NVGG H+ TL LP TRL L + + H DY +E+FFDRHP
Sbjct: 7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHP 61
Query: 90 GAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNE--- 146
G F ILN+YRTG+LH ++C + +EL +WGIDE +E CC Y Q ++
Sbjct: 62 GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDS 121
Query: 147 ----ELKREAETL-REREGEEFDNTCCAEKRKKL---------------------WDLLE 180
L A+ + G+ D E K+L W L E
Sbjct: 122 FGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFE 181
Query: 181 KPNSSVAAKILAIISIMFIVLSTIALSLNT---------LPELQSLDE------FGQSTD 225
P SS A+ +A S+ FI++S L T E++++ + ++
Sbjct: 182 DPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAET 241
Query: 226 NPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKS 285
L ++E VC+ WFT E+L+R + P K +F K LN ID +AILP+Y+ + L S S
Sbjct: 242 EAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGL--SGLS 299
Query: 286 VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIF 345
++V +++ R +RILRI KL RH GL+ LG TLR S NE LLI+FLA+G++IF
Sbjct: 300 SKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 359
Query: 346 SSLVFFAEK---------DEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGL 396
++++++AE+ + T FK+IP FWWA +TMTT+GYGD+YP+T G +VG L
Sbjct: 360 ATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL 419
Query: 397 CCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 434
C +AGVL IA+P+P+IVNNF +Y ++K K+++
Sbjct: 420 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKK 457
>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2a [Homo sapiens]
Length = 613
Score = 293 bits (750), Expect = 5e-79
Identities = 181/492 (36%), Positives = 251/492 (51%), Gaps = 91/492 (18%)
Query: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLR------DCNTH--DSLLEV--------- 72
+ RV LNVGG HE TL LP TRL L DC T D L
Sbjct: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66
Query: 73 -------------------------CDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMM 107
D+ E+FFDRHPG F +LN+YRTG+LH
Sbjct: 67 APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126
Query: 108 EEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTC 167
++C F +EL +WGIDE +E CC Y Q ++ EE ET G+ D+
Sbjct: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184
Query: 168 CAEKR-----------------------KKLWDLLEKPNSSVAAKILAIISIMFIVLSTI 204
A KR ++W L E P SS AA+ +A S+ FI++S
Sbjct: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244
Query: 205 ALSLNTLPELQSLDEFGQSTDN-------------PQLAHVEAVCIAWFTMEYLLRFLSS 251
L T + + N P L +VE VC+ WFT E+L+R + S
Sbjct: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304
Query: 252 PKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 311
P K +F K LN ID +AILP+Y+ + L S S ++V +++ R +RILRI KL
Sbjct: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362
Query: 312 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFK 362
RH GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ + T+FK
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
Query: 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 422
+IP FWWA +TMTT+GYGD+YP+T G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482
Query: 423 QKRQEKAIKRRE 434
++K ++R+
Sbjct: 483 AMAKQKLPRKRK 494
>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2b [Homo sapiens]
Length = 638
Score = 293 bits (750), Expect = 5e-79
Identities = 181/492 (36%), Positives = 251/492 (51%), Gaps = 91/492 (18%)
Query: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLR------DCNTH--DSLLEV--------- 72
+ RV LNVGG HE TL LP TRL L DC T D L
Sbjct: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66
Query: 73 -------------------------CDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMM 107
D+ E+FFDRHPG F +LN+YRTG+LH
Sbjct: 67 APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126
Query: 108 EEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTC 167
++C F +EL +WGIDE +E CC Y Q ++ EE ET G+ D+
Sbjct: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184
Query: 168 CAEKR-----------------------KKLWDLLEKPNSSVAAKILAIISIMFIVLSTI 204
A KR ++W L E P SS AA+ +A S+ FI++S
Sbjct: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244
Query: 205 ALSLNTLPELQSLDEFGQSTDN-------------PQLAHVEAVCIAWFTMEYLLRFLSS 251
L T + + N P L +VE VC+ WFT E+L+R + S
Sbjct: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304
Query: 252 PKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 311
P K +F K LN ID +AILP+Y+ + L S S ++V +++ R +RILRI KL
Sbjct: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362
Query: 312 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFK 362
RH GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ + T+FK
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
Query: 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 422
+IP FWWA +TMTT+GYGD+YP+T G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482
Query: 423 QKRQEKAIKRRE 434
++K ++R+
Sbjct: 483 AMAKQKLPRKRK 494
>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2c [Homo sapiens]
Length = 558
Score = 293 bits (750), Expect = 5e-79
Identities = 181/492 (36%), Positives = 251/492 (51%), Gaps = 91/492 (18%)
Query: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLR------DCNTH--DSLLEV--------- 72
+ RV LNVGG HE TL LP TRL L DC T D L
Sbjct: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66
Query: 73 -------------------------CDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMM 107
D+ E+FFDRHPG F +LN+YRTG+LH
Sbjct: 67 APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126
Query: 108 EEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTC 167
++C F +EL +WGIDE +E CC Y Q ++ EE ET G+ D+
Sbjct: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184
Query: 168 CAEKR-----------------------KKLWDLLEKPNSSVAAKILAIISIMFIVLSTI 204
A KR ++W L E P SS AA+ +A S+ FI++S
Sbjct: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244
Query: 205 ALSLNTLPELQSLDEFGQSTDN-------------PQLAHVEAVCIAWFTMEYLLRFLSS 251
L T + + N P L +VE VC+ WFT E+L+R + S
Sbjct: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304
Query: 252 PKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 311
P K +F K LN ID +AILP+Y+ + L S S ++V +++ R +RILRI KL
Sbjct: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362
Query: 312 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFK 362
RH GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ + T+FK
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
Query: 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 422
+IP FWWA +TMTT+GYGD+YP+T G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482
Query: 423 QKRQEKAIKRRE 434
++K ++R+
Sbjct: 483 AMAKQKLPRKRK 494
>gi|119395748 potassium voltage-gated channel subfamily A member 1
[Homo sapiens]
Length = 495
Score = 280 bits (717), Expect = 3e-75
Identities = 171/459 (37%), Positives = 259/459 (56%), Gaps = 50/459 (10%)
Query: 29 CSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRH 88
C RV +N+ GL E +TL + P T LG + + L NEYFFDR+
Sbjct: 35 CCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLR---------NEYFFDRN 85
Query: 89 PGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEE 147
+F +IL +Y++G RL + FS+E+ ++ + E +E K +
Sbjct: 86 RPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME---------KFREDEGF 136
Query: 148 LKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALS 207
+K E L E+E + +++W L E P SS A+++AI+S+M I++S +
Sbjct: 137 IKEEERPLPEKEYQ-----------RQVWLLFEYPESSGPARVIAIVSVMVILISIVIFC 185
Query: 208 LNTLPELQSLDEFGQST---DNPQLAH-----------VEAVCIAWFTMEYLLRFLSSPK 253
L TLPEL+ +F + DN + + VE +CI WF+ E ++RF + P
Sbjct: 186 LETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPS 245
Query: 254 KWKFFKGPLNAIDLLAILPYYVT----IFLTESNKSVLQFQNVRRVVQIFRIMRILRILK 309
K FFK +N ID++AI+PY++T I E N+ Q ++ ++++ R++R+ RI K
Sbjct: 246 KTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA-ILRVIRLVRVFRIFK 304
Query: 310 LARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFW 369
L+RHS GLQ LG TL+ S ELGLLI FL +G+++FSS V+FAE +E ++ F SIP +FW
Sbjct: 305 LSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFW 364
Query: 370 WATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKA 429
WA ++MTTVGYGD+YP T+ GKIVG LC IAGVL IALP+P+IV+NF+ FY + E+
Sbjct: 365 WAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424
Query: 430 IKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKN 468
+ + S +S ++S E M+I + N
Sbjct: 425 AQLLHVSSPNLASDSDLSRRSSSTMSKS-EYMEIEEDMN 462
>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
member 2 [Homo sapiens]
Length = 630
Score = 280 bits (716), Expect = 4e-75
Identities = 159/435 (36%), Positives = 246/435 (56%), Gaps = 30/435 (6%)
Query: 18 PEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL-RDCNTHDSLLEVCDDY 76
P P R + + LNV G + TL+R P T LG RD H
Sbjct: 28 PAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHP--------- 78
Query: 77 SLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQAR 136
+ +YFFDR P F ILNFYRTG+LH C ++ +EL ++G+ + CC
Sbjct: 79 --ETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEE 136
Query: 137 YHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISI 196
Y ++ + E L+ +A+T + GE T A R+++W E P++S A + ++
Sbjct: 137 YKDRRRENAERLQDDADT--DTAGESALPTMTA--RQRVWRAFENPHTSTMALVFYYVTG 192
Query: 197 MFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAH----VEAVCIAWFTMEYLLRFLSSP 252
FI +S IA + T+P S + + A ++ C+ FT+EYLLR ++P
Sbjct: 193 FFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAP 252
Query: 253 KKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLAR 312
+++F + ++ ID++AILPYY+ + +T++ ++V R+ R+ RI K +R
Sbjct: 253 SRYRFVRSVMSIIDVVAILPYYIGLVMTDN-------EDVSGAFVTLRVFRVFRIFKFSR 305
Query: 313 HSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWAT 372
HS GL+ LG+TL+ +ELG L+ L M I+IF++++F+AEK +KF SIPA+FW+
Sbjct: 306 HSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTI 365
Query: 373 ITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK---A 429
+TMTT+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS Y + +R +K
Sbjct: 366 VTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 425
Query: 430 IKRREALERAKRNGS 444
K R A RA ++GS
Sbjct: 426 KKARLARIRAAKSGS 440
>gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
Length = 647
Score = 279 bits (713), Expect = 9e-75
Identities = 156/418 (37%), Positives = 237/418 (56%), Gaps = 26/418 (6%)
Query: 16 LPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDD 75
LPP P V++ + +NV G E TLDR P T LG +D+
Sbjct: 27 LPPAPG--VKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDA------- 77
Query: 76 YSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQA 135
D EYFFDR P F +LNFYRTGRLH + C +F +EL ++G+ + CC
Sbjct: 78 ---DSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLE 134
Query: 136 RYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIIS 195
Y +K++ E L + E E+ G+ + R++LW E P++S AA + ++
Sbjct: 135 EYRDRKKENAERLAEDEEA--EQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVT 192
Query: 196 IMFIVLSTIALSLNTLP----ELQSLDEFGQSTDNPQLAH-VEAVCIAWFTMEYLLRFLS 250
FI +S IA + T+P +S E PQ ++ C+ FT EYLLR +
Sbjct: 193 GFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFA 252
Query: 251 SPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKL 310
+P + +F + ++ ID++AILPYY+ + + +++ +V R+ R+ RI K
Sbjct: 253 APSRCRFLRSVMSLIDVVAILPYYIGLLVPKND-------DVSGAFVTLRVFRVFRIFKF 305
Query: 311 ARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWW 370
+RHS GL+ LG+TL+ +ELG L+ L M I+IF++++F+AEK + T F SIPA+FW+
Sbjct: 306 SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWY 365
Query: 371 ATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 428
+TMTT+GYGD+ P T+ GKI G +C ++GVLVIALP+P+IV+NFS Y + +R +K
Sbjct: 366 TIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADK 423
>gi|4826782 potassium voltage-gated channel, shaker-related
subfamily, member 2 [Homo sapiens]
Length = 499
Score = 278 bits (710), Expect = 2e-74
Identities = 178/500 (35%), Positives = 271/500 (54%), Gaps = 58/500 (11%)
Query: 14 SSLPPEPMEIVRSKA---CSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLL 70
++LP P + +A C RV +N+ GL E +TL + P T LG + + L
Sbjct: 13 AALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPL 72
Query: 71 EVCDDYSLDDNEYFFDRHPGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYL 129
NEYFFDR+ +F +IL +Y++G RL + FS+E+
Sbjct: 73 R---------NEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEI---------- 113
Query: 130 ESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAK 189
R+++ E+ E + + ++E E +N E ++++W L E P SS A+
Sbjct: 114 ------RFYELGEEAMEMFREDEGYIKEEERPLPEN----EFQRQVWLLFEYPESSGPAR 163
Query: 190 ILAIISIMFIVLSTIALSLNTLPELQSLDE------------------FGQSTD-NPQLA 230
I+AI+S+M I++S ++ L TLP + +E + QST
Sbjct: 164 IIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFF 223
Query: 231 HVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIF--LTESNKSVLQ 288
VE +CI WF+ E+L+RF + P K FF +N ID++AI+PY++T+ L E + Q
Sbjct: 224 IVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQ 283
Query: 289 FQNVRR--VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFS 346
Q ++++ R++R+ RI KL+RHS GLQ LG TL+ S ELGLLI FL +G+++FS
Sbjct: 284 GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS 343
Query: 347 SLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIA 406
S V+FAE DE +++F SIP +FWWA ++MTTVGYGD+ P T+ GKIVG LC IAGVL IA
Sbjct: 344 SAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIA 403
Query: 407 LPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVE 466
LP+P+IV+NF+ FY + E+ + + K S K A +I D +
Sbjct: 404 LPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSS--PDLKKSRSASTISKSDYMEI 461
Query: 467 KNGENMGKKDKVQDNHLSPN 486
+ G N +D ++N + N
Sbjct: 462 QEGVNNSNEDFREENLKTAN 481
>gi|27436986 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 2 [Homo sapiens]
Length = 636
Score = 271 bits (692), Expect = 2e-72
Identities = 173/572 (30%), Positives = 284/572 (49%), Gaps = 39/572 (6%)
Query: 25 RSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYF 84
++K + LNV G + TL+R P T LG +T ++ D EYF
Sbjct: 34 KNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYF 83
Query: 85 FDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQM 144
FDR P F +LNFYRTG+LH C ++ EL ++GI + CC Y +K +
Sbjct: 84 FDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143
Query: 145 NEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTI 204
E L + ++ +E R+ +W E P++S A + ++ FI +S I
Sbjct: 144 AERLMDDNDSENNQESMP-----SLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVI 198
Query: 205 ALSLNTLP--------ELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWK 256
+ T+P EL + + + ++ C+ FT+EYLLR ++P +++
Sbjct: 199 TNVVETVPCGTVPGSKELPCGERYSVA-----FFCLDTACVMIFTVEYLLRLFAAPSRYR 253
Query: 257 FFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTG 316
F + ++ ID++AI+PYY+ + +T + ++V R+ R+ RI K +RHS G
Sbjct: 254 FIRSVMSIIDVVAIMPYYIGLVMTNN-------EDVSGAFVTLRVFRVFRIFKFSRHSQG 306
Query: 317 LQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMT 376
L+ LG+TL+ +ELG L+ L M I+IF++++F+AEK +KF SIPASFW+ +TMT
Sbjct: 307 LRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMT 366
Query: 377 TVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK---AIKRR 433
T+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS Y + +R +K K R
Sbjct: 367 TLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKAR 426
Query: 434 EALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKR 493
A R + GS + E +++ E+MGK + ++ K
Sbjct: 427 LARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKT 486
Query: 494 TLSETSSSKSFETK-EQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAA 552
T E + FE + S + S+ SP + L ++ + N+ A
Sbjct: 487 TNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPAT 546
Query: 553 QSKPKEELEMESIPSPVAPLPTRTEGVIDMRS 584
+ + +EL I P T + +++++
Sbjct: 547 RLRSMQELSTIHIQGSEQPSLTTSRSSLNLKA 578
>gi|5031819 potassium voltage-gated channel, shaker-related
subfamily, member 10 [Homo sapiens]
Length = 511
Score = 270 bits (691), Expect = 3e-72
Identities = 169/456 (37%), Positives = 248/456 (54%), Gaps = 53/456 (11%)
Query: 17 PPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDY 76
PP P +V ++ ++RV +N+ GL E RTL + P T LG + ++ D
Sbjct: 73 PPGPEPVVLNEG-NQRVIINIAGLRFETQLRTLSQFPETLLGD------REKRMQFFDSM 125
Query: 77 SLDDNEYFFDRHPGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYLESCCQA 135
NEYFFDR+ +F IL +Y++G ++ + F+ E+ ++ E+ E+ Q
Sbjct: 126 R---NEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFY---ELGSEAMDQF 179
Query: 136 RYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIIS 195
R +E ++ ETL + ++ W L E P SS AA+ +A++S
Sbjct: 180 RE-------DEGFIKDPETLLPTN----------DIHRQFWLLFEYPESSSAARAVAVVS 222
Query: 196 IMFIVLSTIALSLNTLPELQSLDEF---------------GQSTDNPQLAHVEAVCIAWF 240
++ +V+S L TLPE + E Q+ VE+ CI WF
Sbjct: 223 VLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWF 282
Query: 241 TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIF--LTESNKSVLQFQNVRRVVQI 298
T E +LRF+ P K FF+ +N ID+++I+PY+ T+ L + + Q +++I
Sbjct: 283 TFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRI 342
Query: 299 FRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDD 358
R++R+ RI KL+RHS GLQ LG TL+ S ELGLLI FL +G+++FSS V+FAE DE +
Sbjct: 343 IRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPE 402
Query: 359 TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSE 418
+ F SIP FWWA +TMTTVGYGD+ P T GKIVG LC IAGVL IALP+P+IV+NF+
Sbjct: 403 SHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNY 462
Query: 419 FYKEQKRQEKAIKRREALER-----AKRNGSIVSMN 449
FY + E+ +ER R GS S+N
Sbjct: 463 FYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLN 498
>gi|27436984 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 1 [Homo sapiens]
Length = 655
Score = 270 bits (690), Expect = 4e-72
Identities = 159/473 (33%), Positives = 251/473 (53%), Gaps = 41/473 (8%)
Query: 25 RSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYF 84
++K + LNV G + TL+R P T LG +T ++ D EYF
Sbjct: 34 KNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYF 83
Query: 85 FDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQM 144
FDR P F +LNFYRTG+LH C ++ EL ++GI + CC Y +K +
Sbjct: 84 FDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143
Query: 145 NEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTI 204
E L + ++ +E R+ +W E P++S A + ++ FI +S I
Sbjct: 144 AERLMDDNDSENNQESMP-----SLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVI 198
Query: 205 ALSLNTLP--------ELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWK 256
+ T+P EL + + + ++ C+ FT+EYLLR ++P +++
Sbjct: 199 TNVVETVPCGTVPGSKELPCGERYSVA-----FFCLDTACVMIFTVEYLLRLFAAPSRYR 253
Query: 257 FFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTG 316
F + ++ ID++AI+PYY+ + +T + ++V R+ R+ RI K +RHS G
Sbjct: 254 FIRSVMSIIDVVAIMPYYIGLVMTNN-------EDVSGAFVTLRVFRVFRIFKFSRHSQG 306
Query: 317 LQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMT 376
L+ LG+TL+ +ELG L+ L M I+IF++++F+AEK +KF SIPASFW+ +TMT
Sbjct: 307 LRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMT 366
Query: 377 TVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK---AIKRR 433
T+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS Y + +R +K K R
Sbjct: 367 TLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKAR 426
Query: 434 EALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKV---QDNHL 483
A R + GS + E +++ E+MGK + Q +HL
Sbjct: 427 LARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHL 479
>gi|4504817 potassium voltage-gated channel, shaker-related
subfamily, member 4 [Homo sapiens]
Length = 653
Score = 270 bits (689), Expect = 5e-72
Identities = 164/435 (37%), Positives = 237/435 (54%), Gaps = 58/435 (13%)
Query: 24 VRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEY 83
VR C RV +NV GL E +TL + P T LG + L NEY
Sbjct: 169 VRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLR---------NEY 219
Query: 84 FFDRHPGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKE 142
FFDR+ +F +IL +Y++G RL + F++E+ +++Q E
Sbjct: 220 FFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEV----------------KFYQLGE 263
Query: 143 QMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLS 202
+ + + + +RE E E +K++W L E P SS A+ +AI+S++ I++S
Sbjct: 264 EALLKFREDEGFVREEEDRALPEN---EFKKQIWLLFEYPESSSPARGIAIVSVLVILIS 320
Query: 203 TIALSLNTLPELQS------------------------LDEFGQSTDNPQLAHVEAVCIA 238
+ L TLPE + L+ G + N VE VCI
Sbjct: 321 IVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIV 380
Query: 239 WFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTI---FLTESNKSVLQFQNVRR- 294
WF+ E+++R + P + FFK +N ID+++ILPY++T+ + Q Q
Sbjct: 381 WFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSF 440
Query: 295 -VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAE 353
+++I R++R+ RI KL+RHS GLQ LG TLR S ELGLLI FL +G+++FSS V+FAE
Sbjct: 441 AILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAE 500
Query: 354 KDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413
DE T F+SIP +FWWA +TMTTVGYGD+ P T+ GKIVG LC IAGVL IALP+P+IV
Sbjct: 501 ADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIV 560
Query: 414 NNFSEFYKEQKRQEK 428
+NF+ FY + E+
Sbjct: 561 SNFNYFYHRETENEE 575
>gi|88758565 potassium voltage-gated channel, shaker-related
subfamily, member 3 [Homo sapiens]
Length = 575
Score = 268 bits (686), Expect = 1e-71
Identities = 163/437 (37%), Positives = 243/437 (55%), Gaps = 54/437 (12%)
Query: 16 LPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDD 75
LPP C RV +N+ GL E +TL + P T LG + + L
Sbjct: 89 LPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLR---- 144
Query: 76 YSLDDNEYFFDRHPGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYLESCCQ 134
NEYFFDR+ +F +IL +Y++G R+ + FS+E+
Sbjct: 145 -----NEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEI--------------- 184
Query: 135 ARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAII 194
R++Q E+ E+ + + LRE E + ++++W L E P SS A+ +AI+
Sbjct: 185 -RFYQLGEEAMEKFREDEGFLREEERP----LPRRDFQRQVWLLFEYPESSGPARGIAIV 239
Query: 195 SIMFIVLSTIALSLNTLPELQ------------SLDEFGQSTDNPQLAH---------VE 233
S++ I++S + L TLPE + S + G ST + VE
Sbjct: 240 SVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVE 299
Query: 234 AVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIF--LTESNKSVLQFQN 291
+CI WF+ E L+RF + P K F + +N ID++AI+PY++T+ L E + Q +
Sbjct: 300 TLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMS 359
Query: 292 VRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFF 351
+ ++++ R++R+ RI KL+RHS GLQ LG TL+ S ELGLLI FL +G+++FSS V+F
Sbjct: 360 LA-ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYF 418
Query: 352 AEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPI 411
AE D+ + F SIP +FWWA +TMTTVGYGD++P T+ GKIVG LC IAGVL IALP+P+
Sbjct: 419 AEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPV 478
Query: 412 IVNNFSEFYKEQKRQEK 428
IV+NF+ FY + E+
Sbjct: 479 IVSNFNYFYHRETEGEE 495
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,918,139
Number of Sequences: 37866
Number of extensions: 1614763
Number of successful extensions: 8030
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 7270
Number of HSP's gapped (non-prelim): 636
length of query: 858
length of database: 18,247,518
effective HSP length: 111
effective length of query: 747
effective length of database: 14,044,392
effective search space: 10491160824
effective search space used: 10491160824
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.