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Search of human proteins with 13375901
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13375901 PRKR interacting protein 1 (IL11 inducible) [Homo
sapiens]
(184 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13375901 PRKR interacting protein 1 (IL11 inducible) [Homo sa... 366 e-102
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 53 1e-07
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 53 1e-07
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 48 4e-06
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 48 4e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 46 2e-05
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 44 6e-05
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 42 4e-04
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 42 4e-04
gi|11067749 bromodomain containing protein 3 [Homo sapiens] 42 4e-04
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 41 7e-04
gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens] 41 7e-04
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 40 9e-04
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 40 9e-04
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 40 9e-04
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 40 9e-04
gi|169234949 CWF19-like 2, cell cycle control [Homo sapiens] 40 9e-04
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap... 40 0.001
gi|34996489 pleckstrin homology domain interacting protein [Homo... 40 0.001
gi|27883882 P18SRP protein [Homo sapiens] 40 0.001
gi|157785548 PAS domain containing 1 [Homo sapiens] 40 0.001
gi|148746195 trichohyalin [Homo sapiens] 40 0.001
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 40 0.001
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 39 0.002
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 39 0.002
gi|239752449 PREDICTED: hypothetical protein [Homo sapiens] 39 0.003
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 39 0.003
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 39 0.003
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 39 0.003
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 39 0.003
>gi|13375901 PRKR interacting protein 1 (IL11 inducible) [Homo
sapiens]
Length = 184
Score = 366 bits (939), Expect = e-102
Identities = 184/184 (100%), Positives = 184/184 (100%)
Query: 1 MASPAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPP 60
MASPAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPP
Sbjct: 1 MASPAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPP 60
Query: 61 PEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAA 120
PEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAA
Sbjct: 61 PEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAA 120
Query: 121 EEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPSF 180
EEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPSF
Sbjct: 121 EEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPSF 180
Query: 181 TMGR 184
TMGR
Sbjct: 181 TMGR 184
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 53.1 bits (126), Expect = 1e-07
Identities = 48/174 (27%), Positives = 77/174 (44%), Gaps = 16/174 (9%)
Query: 11 PPRPKKEPQTLVIPKNAAEEQ------KLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFV 64
P P +E +PK+ EE+ K +E K+P P+ EK P+ P E
Sbjct: 631 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEA 690
Query: 65 RDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLE---KNKIAAE 121
+ S A G GE +E +++ ++ EK K D +K+ E K + AE
Sbjct: 691 K----SKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK-DVPEKKKAESPVKEEAVAE 745
Query: 122 EQTAKRRKKRQKLKEKKLLAKKMKLEQKKQE--GPGQPKEQGSSSSAEASGTEE 173
T + K KE K K ++ E++K++ G G +E+GS A+ S E+
Sbjct: 746 VVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKED 799
Score = 30.4 bits (67), Expect = 0.90
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 10/71 (14%)
Query: 114 EKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEG-----PGQPKEQ-----GSS 163
E+ K AAEE+ + + +++ KK K E K++EG GQ +E+ S
Sbjct: 486 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 545
Query: 164 SSAEASGTEEE 174
AE G+E+E
Sbjct: 546 DQAEEGGSEKE 556
Score = 28.9 bits (63), Expect = 2.6
Identities = 18/79 (22%), Positives = 39/79 (49%), Gaps = 6/79 (7%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQ---TAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQP 157
EK +++ E+ ++ +E+ A+ +++ + +E+++ AKK + K P
Sbjct: 465 EKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV---KATAPEVK 521
Query: 158 KEQGSSSSAEASGTEEEEE 176
+E+G E EEEE+
Sbjct: 522 EEEGEKEEEEGQEEEEEED 540
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 53.1 bits (126), Expect = 1e-07
Identities = 48/174 (27%), Positives = 77/174 (44%), Gaps = 16/174 (9%)
Query: 11 PPRPKKEPQTLVIPKNAAEEQ------KLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFV 64
P P +E +PK+ EE+ K +E K+P P+ EK P+ P E
Sbjct: 255 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEA 314
Query: 65 RDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLE---KNKIAAE 121
+ S A G GE +E +++ ++ EK K D +K+ E K + AE
Sbjct: 315 K----SKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK-DVPEKKKAESPVKEEAVAE 369
Query: 122 EQTAKRRKKRQKLKEKKLLAKKMKLEQKKQE--GPGQPKEQGSSSSAEASGTEE 173
T + K KE K K ++ E++K++ G G +E+GS A+ S E+
Sbjct: 370 VVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKED 423
Score = 30.4 bits (67), Expect = 0.90
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 10/71 (14%)
Query: 114 EKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEG-----PGQPKEQ-----GSS 163
E+ K AAEE+ + + +++ KK K E K++EG GQ +E+ S
Sbjct: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 169
Query: 164 SSAEASGTEEE 174
AE G+E+E
Sbjct: 170 DQAEEGGSEKE 180
Score = 28.9 bits (63), Expect = 2.6
Identities = 18/79 (22%), Positives = 39/79 (49%), Gaps = 6/79 (7%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQ---TAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQP 157
EK +++ E+ ++ +E+ A+ +++ + +E+++ AKK + K P
Sbjct: 89 EKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV---KATAPEVK 145
Query: 158 KEQGSSSSAEASGTEEEEE 176
+E+G E EEEE+
Sbjct: 146 EEEGEKEEEEGQEEEEEED 164
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 48.1 bits (113), Expect = 4e-06
Identities = 35/125 (28%), Positives = 60/125 (48%), Gaps = 5/125 (4%)
Query: 47 PIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLD 106
P P + + P P P + + S + +G + Q ++ E+QK +
Sbjct: 680 PPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKETRKQEKERQKQEKERQKQE 739
Query: 107 AEFQK---RLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSS 163
E +K + EK + E++ K+ K+RQK +EKK +K+ L ++K +GP P + G
Sbjct: 740 KEREKERQKQEKEREKQEKEREKQEKERQK-QEKKAQGRKLSL-RRKADGPPGPHDGGDR 797
Query: 164 SSAEA 168
SAEA
Sbjct: 798 PSAEA 802
Score = 28.1 bits (61), Expect = 4.5
Identities = 15/59 (25%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 118 IAAEEQTAKRRKKRQKL-KEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
+ + ++T K+ K+RQK KE++ K+ + E++KQE + +E+ + +E++
Sbjct: 715 LGSSKETRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKK 773
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 48.1 bits (113), Expect = 4e-06
Identities = 39/165 (23%), Positives = 75/165 (45%), Gaps = 16/165 (9%)
Query: 29 EEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRR 88
EE++++ +R +K + EK+ +P PE +R+ E + + R
Sbjct: 469 EERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQE-QER 527
Query: 89 EYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQ 148
E +R+ + EK+K E +K EK + +E+ ++ K+ ++ KEK+ +KMK ++
Sbjct: 528 EKEREKDRERQQEKEK---ELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQE 584
Query: 149 KKQE------------GPGQPKEQGSSSSAEASGTEEEEEVPSFT 181
K+ E P +P + E+ + +EE P FT
Sbjct: 585 KECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFT 629
Score = 33.5 bits (75), Expect = 0.11
Identities = 39/182 (21%), Positives = 72/182 (39%), Gaps = 29/182 (15%)
Query: 12 PRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMGSS 71
P P EPQ PK E + ++ E + + ++ P +F+R+
Sbjct: 811 PYPHAEPQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQLEAHPKADFIRE----- 865
Query: 72 AGAGSGEFHVYRHLRRR-EYQRQDYMDAMAEKQKLDAEFQKRL---EKNKIAAEEQTAKR 127
S E V + L R E R + DA + +A QK L ++ +I+A E R
Sbjct: 866 ----SSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISAVESQPSR 921
Query: 128 RKK-------RQKLKEK---------KLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGT 171
++ QK E+ K+ ++ + ++ + +PK++G S+E
Sbjct: 922 KRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPKP 981
Query: 172 EE 173
E+
Sbjct: 982 EK 983
Score = 29.3 bits (64), Expect = 2.0
Identities = 28/135 (20%), Positives = 62/135 (45%), Gaps = 8/135 (5%)
Query: 47 PIPEKMSEWAPRPPPEFVRDVMGS--SAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQK 104
P P+ +++ P P + V G S + E +++ RR Q+ + A+ +K
Sbjct: 408 PPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRR---QQSEISAAVERARK 464
Query: 105 LDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQ---PKEQG 161
E ++R+E+ + AA + KR ++ + EK+ ++++ ++++E + KEQ
Sbjct: 465 RREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQE 524
Query: 162 SSSSAEASGTEEEEE 176
E E ++
Sbjct: 525 QEREKEREKDRERQQ 539
Score = 28.5 bits (62), Expect = 3.4
Identities = 23/96 (23%), Positives = 51/96 (53%), Gaps = 7/96 (7%)
Query: 85 LRRREYQRQDYMDAMAEKQKLD-AEFQKRLEKNKIAAEEQTAK---RRKKRQKLKEKKLL 140
+ R +R++ M E++K AE KRL++ E+Q + R ++R+K +E++
Sbjct: 459 VERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKERERE-- 516
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
K+++ EQ+++ + K++ E +E+E+
Sbjct: 517 -KELEKEQEQEREKEREKDRERQQEKEKELEKEQEK 551
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 45.8 bits (107), Expect = 2e-05
Identities = 46/203 (22%), Positives = 84/203 (41%), Gaps = 25/203 (12%)
Query: 3 SPAASSVRPP-RPKKEPQTLVIPKNAAEEQKLKLERLMKN------PDKAVPIPEKMSEW 55
SP ++ P R +++ + P A E K + +R N P P P
Sbjct: 496 SPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTP 555
Query: 56 AP----RPPPEFVRD-------------VMGSSAGAGSGEFH-VYRHLRRREYQRQDYMD 97
AP +PP E D V S AG+ + R L + Q ++ +
Sbjct: 556 APPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQRE 615
Query: 98 AMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQP 157
++++L AE KR+ + ++A E + R+ + +E++ +K + EQ++QE +
Sbjct: 616 REEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQ 675
Query: 158 KEQGSSSSAEASGTEEEEEVPSF 180
KE+ + S E + + E F
Sbjct: 676 KEEAEARSREEAERQRLEREKHF 698
Score = 35.0 bits (79), Expect = 0.036
Identities = 21/97 (21%), Positives = 47/97 (48%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
R + Q + +KQK +AE + R E + E + +++++++ + +K L + MK
Sbjct: 659 REKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKR 718
Query: 147 EQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPSFTMG 183
+K + + K+ ++A S E + V + + G
Sbjct: 719 TRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
Score = 32.7 bits (73), Expect = 0.18
Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 22/126 (17%)
Query: 41 NPDKAVPIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMA 100
+P AVP+ + + +P P R V + GE RR+
Sbjct: 353 HPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGE-------RRKPNAGGS------ 399
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
A ++R E + + +E K+ K+R+ KEK LA++ L +K+Q P P+ +
Sbjct: 400 -----PAPVRRRPEASPVQKKE---KKDKERENEKEKSALARERSL-KKRQSLPASPRAR 450
Query: 161 GSSSSA 166
S+S+A
Sbjct: 451 LSASTA 456
Score = 30.8 bits (68), Expect = 0.69
Identities = 44/176 (25%), Positives = 68/176 (38%), Gaps = 46/176 (26%)
Query: 4 PAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKN----PDKAVPIPEKMSEWA--- 56
P S++ P P P + KNA ++L LE + P A P E S A
Sbjct: 38 PPMSALVPDTPPDTPPAM---KNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSR 94
Query: 57 -PRPPPEFVRDVMGSSAGAG--------------------SGEFHVYRHLRRRE------ 89
P PP RD + +GE H RR E
Sbjct: 95 GPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLA 154
Query: 90 ------YQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEE-QTAKRRKKRQKLKEKK 138
++++ A+ EKQ E ++RLE+ ++ AE+ + A ++RQKL++ K
Sbjct: 155 AKKAVWLEKEEKAKALREKQL--QERRRRLEEQRLKAEQRRAALEERQRQKLEKNK 208
Score = 29.3 bits (64), Expect = 2.0
Identities = 32/132 (24%), Positives = 47/132 (35%), Gaps = 28/132 (21%)
Query: 10 RPPRPKKEPQTLVIP-----------KNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPR 58
RPPR +P +P K A E KL ER ++A + K + W +
Sbjct: 107 RPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKER---REERAKYLAAKKAVWLEK 163
Query: 59 PPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKI 118
E + RR E QR + A + L+ +++LEKNK
Sbjct: 164 -----------EEKAKALREKQLQERRRRLEEQR---LKAEQRRAALEERQRQKLEKNKE 209
Query: 119 AAEEQTAKRRKK 130
E + KK
Sbjct: 210 RYEAAIQRSVKK 221
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 44.3 bits (103), Expect = 6e-05
Identities = 49/174 (28%), Positives = 76/174 (43%), Gaps = 22/174 (12%)
Query: 2 ASPAASSVRPPRPKKEPQ---TLVIPKNAAEEQKLKLERLMKNPDKAVPI------PEKM 52
A P S P P P T K + E+ KL+L+R + K + + EK+
Sbjct: 301 APPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKL 360
Query: 53 SEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQK- 111
E A R E A E + RRE + +D + AEKQ+L E +K
Sbjct: 361 KEEAKRAKEE---------AKKKKEEEKELKEKERREKREKDEKEK-AEKQRLKEERRKE 410
Query: 112 RLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQ--KKQEGPGQPKEQGSS 163
R E + EE+ K +KR + +EK++ A+K ++ + +K + P PK S
Sbjct: 411 RQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGS 464
Score = 37.7 bits (86), Expect = 0.006
Identities = 42/187 (22%), Positives = 83/187 (44%), Gaps = 29/187 (15%)
Query: 8 SVRPPRPKKEPQTL----VIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEF 63
+VRPP+ K P T + P++ E + + ++ + + P E P PP +
Sbjct: 247 AVRPPQIKSLPATPQGKNMTPESEVLESFPEEDSVLSHSSLSSPSSTSSPEGPPAPPKQH 306
Query: 64 VRDVMGSSAGAGSGEFHVYRHLRR------------REYQRQDYMDAMAEKQKLDAEFQK 111
+ + F LRR + + Q + + ++ KL AE ++
Sbjct: 307 ----------SSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREE 356
Query: 112 R--LEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEAS 169
+ L++ A+E+ K++++ ++LKEK+ K+ K E++K E + KE+ EA
Sbjct: 357 KEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAE-KQRLKEERRKERQEAL 415
Query: 170 GTEEEEE 176
+ EE+
Sbjct: 416 EAKLEEK 422
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 41.6 bits (96), Expect = 4e-04
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 88 REYQRQDYMDAMA------EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLA 141
+ YQ+ D+ DA EK++ + E KR + EE+ K + KR+KL+E K
Sbjct: 164 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTF 223
Query: 142 KKMKLEQKKQEGPGQPKEQGSSSSAEASGTEE 173
KK +++ +K + +PKE+ S G E
Sbjct: 224 KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 255
Score = 34.3 bits (77), Expect = 0.062
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 13/128 (10%)
Query: 60 PPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQK------LDAEF---Q 110
P E + ++ G E L RRE +RQ + E+QK DA
Sbjct: 69 PDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 128
Query: 111 KRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASG 170
+R++ + AE +T ++ +K + +E+ + + + + Q+ + E+ E
Sbjct: 129 RRMQND--TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE- 185
Query: 171 TEEEEEVP 178
EEEEE P
Sbjct: 186 -EEEEEKP 192
Score = 28.5 bits (62), Expect = 3.4
Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 17/178 (9%)
Query: 15 KKEPQTLVIPKNAAEEQ--KLKLERLMKNPDKAVPIPEKMSEWA---PRPPPEFVRDVMG 69
+++P+ I +N EE+ K++ +R DK E++ + + P E V+ M
Sbjct: 189 EEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD 248
Query: 70 SSAG-----AGSGEF--HVYRHLRRREYQRQDYMDAMAEKQKLDA---EFQKRLEK-NKI 118
G + +GEF H +H + R ++ K+ A E KRLE+ +
Sbjct: 249 RKKGFTEVKSQNGEFMTHKLKHTENT-FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 307
Query: 119 AAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
E ++ + K +QK +E L +++K +++++ + +EQ EEEE
Sbjct: 308 RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 365
Score = 27.3 bits (59), Expect = 7.6
Identities = 15/79 (18%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQ----KRLEKNKIAAEEQTAKRRKKRQKLKEKKLLA 141
RR E + +++ ++Q+ E + KR E+ K+ EE+ +++++ + ++
Sbjct: 307 RRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK 366
Query: 142 KKMKLEQKKQEGPGQPKEQ 160
+++K E +++ K Q
Sbjct: 367 RRLKEEIERRRAEAAEKRQ 385
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 41.6 bits (96), Expect = 4e-04
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 88 REYQRQDYMDAMA------EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLA 141
+ YQ+ D+ DA EK++ + E KR + EE+ K + KR+KL+E K
Sbjct: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTF 229
Query: 142 KKMKLEQKKQEGPGQPKEQGSSSSAEASGTEE 173
KK +++ +K + +PKE+ S G E
Sbjct: 230 KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 261
Score = 34.3 bits (77), Expect = 0.062
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 13/128 (10%)
Query: 60 PPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQK------LDAEF---Q 110
P E + ++ G E L RRE +RQ + E+QK DA
Sbjct: 75 PDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 134
Query: 111 KRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASG 170
+R++ + AE +T ++ +K + +E+ + + + + Q+ + E+ E
Sbjct: 135 RRMQND--TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE- 191
Query: 171 TEEEEEVP 178
EEEEE P
Sbjct: 192 -EEEEEKP 198
Score = 30.4 bits (67), Expect = 0.90
Identities = 24/93 (25%), Positives = 48/93 (51%), Gaps = 10/93 (10%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAE---FQKRLEKNKIAAEE--QTAKRRKKRQKLKEKKLL 140
RRRE +RQ E+ +L+AE +Q+ + + AA E + A++ + RQK +E+ L
Sbjct: 6 RRRELRRQ-----KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEE 173
++E Q + + ++++ + G +E
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE 93
Score = 28.5 bits (62), Expect = 3.4
Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 17/178 (9%)
Query: 15 KKEPQTLVIPKNAAEEQ--KLKLERLMKNPDKAVPIPEKMSEWA---PRPPPEFVRDVMG 69
+++P+ I +N EE+ K++ +R DK E++ + + P E V+ M
Sbjct: 195 EEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD 254
Query: 70 SSAG-----AGSGEF--HVYRHLRRREYQRQDYMDAMAEKQKLDA---EFQKRLEK-NKI 118
G + +GEF H +H + R ++ K+ A E KRLE+ +
Sbjct: 255 RKKGFTEVKSQNGEFMTHKLKHTENT-FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 313
Query: 119 AAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
E ++ + K +QK +E L +++K +++++ + +EQ EEEE
Sbjct: 314 RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 371
Score = 27.3 bits (59), Expect = 7.6
Identities = 15/79 (18%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQ----KRLEKNKIAAEEQTAKRRKKRQKLKEKKLLA 141
RR E + +++ ++Q+ E + KR E+ K+ EE+ +++++ + ++
Sbjct: 313 RRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK 372
Query: 142 KKMKLEQKKQEGPGQPKEQ 160
+++K E +++ K Q
Sbjct: 373 RRLKEEIERRRAEAAEKRQ 391
>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
Length = 726
Score = 41.6 bits (96), Expect = 4e-04
Identities = 41/134 (30%), Positives = 59/134 (44%), Gaps = 9/134 (6%)
Query: 37 RLMKNPDKAVPIPEKMSEWAPRPPP--EFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQD 94
R K PD+ V P + AP E R SS+ +GS + R R E Q Q
Sbjct: 411 RFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQ- 469
Query: 95 YMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGP 154
A ++L A Q + K K +E+ K +KK+ K KEK+ K+K E++K+
Sbjct: 470 ---LKAVHEQLAALSQAPVNKPK-KKKEKKEKEKKKKDKEKEKE--KHKVKAEEEKKAKV 523
Query: 155 GQPKEQGSSSSAEA 168
P +Q A A
Sbjct: 524 APPAKQAQQKKAPA 537
Score = 27.3 bits (59), Expect = 7.6
Identities = 25/99 (25%), Positives = 47/99 (47%), Gaps = 7/99 (7%)
Query: 78 EFHVYRHLRRREYQRQDYMDAMAEKQK---LDAEFQKRLEKNKIAAEEQTAKRRKKR-QK 133
+F + RE +R Y+ + +K++ A +K+ K+K ++ K +KR Q
Sbjct: 617 DFETLKPTTLRELER--YVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQD 674
Query: 134 LKEKKLLAKKMKLEQKKQEGP-GQPKEQGSSSSAEASGT 171
+ + +KK ++K P G P SSSS+E+ +
Sbjct: 675 VSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSS 713
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 40.8 bits (94), Expect = 7e-04
Identities = 27/91 (29%), Positives = 52/91 (57%), Gaps = 9/91 (9%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+R+E +++ + EK+K E +KR EK EE+ KR++KR+K KE++ ++ +
Sbjct: 28 KRKEKRKEKRKEK--EKKKKTKETEKRKEK-----EEEEKKRKRKRKKKKEEE--EREEE 78
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
E++++E + KE+G + +EEE
Sbjct: 79 EEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109
Score = 39.7 bits (91), Expect = 0.001
Identities = 24/90 (26%), Positives = 47/90 (52%), Gaps = 3/90 (3%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
++ + ++ + E++K +KR EK K E++ K+ K+ +K KEK+ KK K
Sbjct: 7 KKETEETEETEETEEEEEKEGKRKEKRKEKRK---EKEKKKKTKETEKRKEKEEEEKKRK 63
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
++KK++ + +E+ E E+EE
Sbjct: 64 RKRKKKKEEEEREEEEEEEEEEKEEEEKEE 93
Score = 37.4 bits (85), Expect = 0.007
Identities = 25/79 (31%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQ---KLKEKKLLAKKMKLEQKKQEGPGQP 157
+K+K + E + E+ + EE+ KR++KR+ K KEKK K+ + ++K+E +
Sbjct: 4 KKKKKETEETEETEETE-EEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKR 62
Query: 158 KEQGSSSSAEASGTEEEEE 176
K + E EEEEE
Sbjct: 63 KRKRKKKKEEEEREEEEEE 81
Score = 35.4 bits (80), Expect = 0.028
Identities = 22/98 (22%), Positives = 50/98 (51%), Gaps = 3/98 (3%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
+++ +++ + E ++ + E +K ++ + E++ K +KK+ K EK+ K+ +
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKR---KEKEE 57
Query: 147 EQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPSFTMGR 184
E+KK++ + K++ E EEE+E GR
Sbjct: 58 EEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGR 95
Score = 29.6 bits (65), Expect = 1.5
Identities = 17/75 (22%), Positives = 42/75 (56%), Gaps = 2/75 (2%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+R+E + ++ K+K + E ++ E+ + +E+ K +R+K K+K+ +K +
Sbjct: 51 KRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKR--RRKEE 108
Query: 146 LEQKKQEGPGQPKEQ 160
E+KK++ + K++
Sbjct: 109 EEEKKKKRRRKTKKK 123
Score = 28.9 bits (63), Expect = 2.6
Identities = 19/84 (22%), Positives = 42/84 (50%), Gaps = 6/84 (7%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNK------IAAEEQTAKRRKKRQKLKE 136
R +R+E +++ ++++ + E +KR K K EE+ + +K ++ KE
Sbjct: 33 RKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKE 92
Query: 137 KKLLAKKMKLEQKKQEGPGQPKEQ 160
+ KK K ++K+E + K++
Sbjct: 93 EGRRRKKKKKRRRKEEEEEKKKKR 116
Score = 26.9 bits (58), Expect = 9.9
Identities = 19/91 (20%), Positives = 45/91 (49%), Gaps = 16/91 (17%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
R+ + +++ + K+K + E +++ ++ K EE+ + ++ ++ KE
Sbjct: 37 RKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKE--------- 87
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
E++K+EG + K++ + EEEEE
Sbjct: 88 -EEEKEEGRRRKKKK------KRRRKEEEEE 111
>gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens]
Length = 656
Score = 40.8 bits (94), Expect = 7e-04
Identities = 32/138 (23%), Positives = 60/138 (43%), Gaps = 10/138 (7%)
Query: 3 SPAASSVRPPRP---KKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRP 59
+P+ S RP RP +++PQ E++ +K P +A PE +S+
Sbjct: 227 TPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPL 286
Query: 60 PPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIA 119
P+ +D +G F + + + ++D K+ + + KR EK
Sbjct: 287 DPDLYQDFC-------AGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEK 339
Query: 120 AEEQTAKRRKKRQKLKEK 137
+E+ KR +++QK K+K
Sbjct: 340 KKEERYKRHRQKQKHKDK 357
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 40.4 bits (93), Expect = 9e-04
Identities = 23/77 (29%), Positives = 45/77 (58%), Gaps = 10/77 (12%)
Query: 86 RRREYQRQDYMDAMAEKQKLDA--------EFQKRLEKNKIAAEEQTAKRRKKRQKLKEK 137
RRRE + + + + KQ+ +A E Q+RLE+N++ EE+ A+ R + ++ K K
Sbjct: 820 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 879
Query: 138 KLLAKKMK--LEQKKQE 152
+L ++ K + Q++Q+
Sbjct: 880 ELEVQRQKELMRQRQQQ 896
Score = 30.0 bits (66), Expect = 1.2
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 4/77 (5%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
EK K Q+R E A E+ ++R++ + +++++L ++ + E+K++E +E
Sbjct: 724 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE----EEEL 779
Query: 161 GSSSSAEASGTEEEEEV 177
EA + E+E+
Sbjct: 780 ARRKQEEALRRQREQEI 796
Score = 29.3 bits (64), Expect = 2.0
Identities = 18/89 (20%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+R E +R+ + +++++ +++ E+ + EE+ RRK+ + L+ ++ +++
Sbjct: 743 KREEEERKRQEELRRQQEEI---LRRQQEEERKRREEEELARRKQEEALRRQR--EQEIA 797
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEE 174
L ++++E Q +E+ E EEE
Sbjct: 798 LRRQREEEERQQQEEALRRLEERRREEEE 826
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 40.4 bits (93), Expect = 9e-04
Identities = 23/77 (29%), Positives = 45/77 (58%), Gaps = 10/77 (12%)
Query: 86 RRREYQRQDYMDAMAEKQKLDA--------EFQKRLEKNKIAAEEQTAKRRKKRQKLKEK 137
RRRE + + + + KQ+ +A E Q+RLE+N++ EE+ A+ R + ++ K K
Sbjct: 847 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 906
Query: 138 KLLAKKMK--LEQKKQE 152
+L ++ K + Q++Q+
Sbjct: 907 ELEVQRQKELMRQRQQQ 923
Score = 30.0 bits (66), Expect = 1.2
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 4/77 (5%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
EK K Q+R E A E+ ++R++ + +++++L ++ + E+K++E +E
Sbjct: 751 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE----EEEL 806
Query: 161 GSSSSAEASGTEEEEEV 177
EA + E+E+
Sbjct: 807 ARRKQEEALRRQREQEI 823
Score = 29.3 bits (64), Expect = 2.0
Identities = 18/89 (20%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+R E +R+ + +++++ +++ E+ + EE+ RRK+ + L+ ++ +++
Sbjct: 770 KREEEERKRQEELRRQQEEI---LRRQQEEERKRREEEELARRKQEEALRRQR--EQEIA 824
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEE 174
L ++++E Q +E+ E EEE
Sbjct: 825 LRRQREEEERQQQEEALRRLEERRREEEE 853
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 40.4 bits (93), Expect = 9e-04
Identities = 23/77 (29%), Positives = 45/77 (58%), Gaps = 10/77 (12%)
Query: 86 RRREYQRQDYMDAMAEKQKLDA--------EFQKRLEKNKIAAEEQTAKRRKKRQKLKEK 137
RRRE + + + + KQ+ +A E Q+RLE+N++ EE+ A+ R + ++ K K
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 138 KLLAKKMK--LEQKKQE 152
+L ++ K + Q++Q+
Sbjct: 886 ELEVQRQKELMRQRQQQ 902
Score = 30.0 bits (66), Expect = 1.2
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 4/77 (5%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
EK K Q+R E A E+ ++R++ + +++++L ++ + E+K++E +E
Sbjct: 730 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE----EEEL 785
Query: 161 GSSSSAEASGTEEEEEV 177
EA + E+E+
Sbjct: 786 ARRKQEEALRRQREQEI 802
Score = 29.3 bits (64), Expect = 2.0
Identities = 18/89 (20%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+R E +R+ + +++++ +++ E+ + EE+ RRK+ + L+ ++ +++
Sbjct: 749 KREEEERKRQEELRRQQEEI---LRRQQEEERKRREEEELARRKQEEALRRQR--EQEIA 803
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEE 174
L ++++E Q +E+ E EEE
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEE 832
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 40.4 bits (93), Expect = 9e-04
Identities = 23/77 (29%), Positives = 45/77 (58%), Gaps = 10/77 (12%)
Query: 86 RRREYQRQDYMDAMAEKQKLDA--------EFQKRLEKNKIAAEEQTAKRRKKRQKLKEK 137
RRRE + + + + KQ+ +A E Q+RLE+N++ EE+ A+ R + ++ K K
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 138 KLLAKKMK--LEQKKQE 152
+L ++ K + Q++Q+
Sbjct: 886 ELEVQRQKELMRQRQQQ 902
Score = 30.0 bits (66), Expect = 1.2
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 4/77 (5%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
EK K Q+R E A E+ ++R++ + +++++L ++ + E+K++E +E
Sbjct: 730 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE----EEEL 785
Query: 161 GSSSSAEASGTEEEEEV 177
EA + E+E+
Sbjct: 786 ARRKQEEALRRQREQEI 802
Score = 29.3 bits (64), Expect = 2.0
Identities = 18/89 (20%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+R E +R+ + +++++ +++ E+ + EE+ RRK+ + L+ ++ +++
Sbjct: 749 KREEEERKRQEELRRQQEEI---LRRQQEEERKRREEEELARRKQEEALRRQR--EQEIA 803
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEE 174
L ++++E Q +E+ E EEE
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEE 832
>gi|169234949 CWF19-like 2, cell cycle control [Homo sapiens]
Length = 894
Score = 40.4 bits (93), Expect = 9e-04
Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 23/132 (17%)
Query: 68 MGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIA-------- 119
M +S A SG F + + R+ Q ++ + + K + E ++R ++ K
Sbjct: 1 MATSMAAASGRFESAKSIEERKEQTRNARAEVLRQAKANFEKEERRKELKRLRGEDTWML 60
Query: 120 ----------AEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEAS 169
++E + K++KK+ K +K KK K +++K E K SS S+ +S
Sbjct: 61 PDVNERIEQFSQEHSVKKKKKKDKHSKKAKKEKKKKSKKQKYE-----KNNESSDSSSSS 115
Query: 170 GTEEEEEVPSFT 181
E E VPS T
Sbjct: 116 EDEWVEAVPSQT 127
>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo
sapiens]
Length = 2211
Score = 40.0 bits (92), Expect = 0.001
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 6/78 (7%)
Query: 106 DAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSS 165
+ E +K+ EK+K+ Q K+ + + KL+ KK KK K ++ EG + SS
Sbjct: 911 EEEARKKKEKDKL---RQLLKKERLKAKLQRKK---KKRKGSDEEDEGEEEESSSSEESS 964
Query: 166 AEASGTEEEEEVPSFTMG 183
+E EEEEE F G
Sbjct: 965 SEEEEMEEEEEEEEFGPG 982
Score = 38.1 bits (87), Expect = 0.004
Identities = 25/65 (38%), Positives = 41/65 (63%), Gaps = 10/65 (15%)
Query: 118 IAAEEQTAKRRKK---RQKLKEKKLLAKKMKLEQKKQEGPGQPK----EQGSSSSAEASG 170
+ EE+ K+++K RQ LK+++L K KL++KK++ G + E+ SSS+E S
Sbjct: 908 LTPEEEARKKKEKDKLRQLLKKERL---KAKLQRKKKKRKGSDEEDEGEEEESSSSEESS 964
Query: 171 TEEEE 175
+EEEE
Sbjct: 965 SEEEE 969
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 40.0 bits (92), Expect = 0.001
Identities = 37/154 (24%), Positives = 65/154 (42%), Gaps = 11/154 (7%)
Query: 16 KEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMS-EWAPRPPPEFVR--------D 66
KE + + KN A E L L K + + E PRP E +
Sbjct: 764 KENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGE 823
Query: 67 VMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAK 126
V+ S G E + DY D A+ ++ + K++ KNK E ++
Sbjct: 824 VVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAG-INLQPPKKVPKNKTKKAESSSD 882
Query: 127 RRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
++ +K K+K++ +K K+ ++K +GP PK++
Sbjct: 883 EEEESEKQKQKQIKKEKKKVNEEK-DGPISPKKK 915
>gi|27883882 P18SRP protein [Homo sapiens]
Length = 155
Score = 40.0 bits (92), Expect = 0.001
Identities = 28/118 (23%), Positives = 60/118 (50%), Gaps = 7/118 (5%)
Query: 59 PPPEFVRDVMGSSAGAG---SGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEK 115
P + V DV +S+ + E + + L+ + ++ K+K+ + +++
Sbjct: 36 PKRDIVLDVSSTSSEDSDEENEELNKLQALQEKRINEEEEKKKEKSKEKIKLKKKRKRSY 95
Query: 116 NKIAAEEQTAKRRK----KRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEAS 169
+ + EE T+K++K K++K KEKK +KK K +K+++ + K + +S+E S
Sbjct: 96 SSSSTEEDTSKQKKQKYQKKEKKKEKKSKSKKGKHHKKEKKKRKKEKHSSTPNSSEFS 153
>gi|157785548 PAS domain containing 1 [Homo sapiens]
Length = 773
Score = 40.0 bits (92), Expect = 0.001
Identities = 25/86 (29%), Positives = 51/86 (59%), Gaps = 12/86 (13%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAK------RRKKRQKLKE 136
+HL+ ++ Q ++ + + E++K+ + +K EK K+ ++ K RR+K++KL+E
Sbjct: 487 QHLKEQQRQLREQLQQLREQRKVQKQ-KKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQE 545
Query: 137 KK-----LLAKKMKLEQKKQEGPGQP 157
+K +L K+ + EQ+KQ+ QP
Sbjct: 546 RKKWQGQMLQKEPEEEQQKQQLQEQP 571
Score = 34.3 bits (77), Expect = 0.062
Identities = 39/176 (22%), Positives = 78/176 (44%), Gaps = 27/176 (15%)
Query: 25 KNAAEEQKLKLERLMKNPD--KAVPIPEKMSEWA---------------PRPPPEFVRDV 67
+N +L ++ L K P+ + V IP+ S A P P P+ V+
Sbjct: 396 QNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCF 455
Query: 68 MG---SSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQT 124
G S++ +GE ++ Q ++++L + Q+ E+ K+ Q
Sbjct: 456 CGLSLSNSLKNTGELQEPCVAFNQQQLVQQEQHLKEQQRQLREQLQQLREQRKV----QK 511
Query: 125 AKRRKKRQKLKEKKLLAKKMKLE---QKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
K+ ++++KL+E+K+ KK E QKK++ + K QG E ++++++
Sbjct: 512 QKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQL 567
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 39.7 bits (91), Expect = 0.001
Identities = 44/186 (23%), Positives = 84/186 (45%), Gaps = 25/186 (13%)
Query: 13 RPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKA--VPIPEKMSEWAPRPPPEFVRDVMGS 70
R K++ Q + + EEQ K ERL + + + + EW R + + S
Sbjct: 138 RQKRQEQERELAEG--EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195
Query: 71 SAGAGSGEFHVYRHLRRREY-------------QRQDYMDAMAEKQKLDAEFQKR----- 112
G + EF LRRRE QR++ D + ++++ + E++KR
Sbjct: 196 CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE-EKEWRKRETVLR 254
Query: 113 LEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQ--PKEQGSSSSAEASG 170
E+ K+ EE +R + ++ + +KL ++++ E++++E Q +EQ E
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 171 TEEEEE 176
E++EE
Sbjct: 315 REQQEE 320
Score = 39.3 bits (90), Expect = 0.002
Identities = 34/135 (25%), Positives = 63/135 (46%), Gaps = 18/135 (13%)
Query: 54 EWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQ-RQDYMDAMAEKQKLDAEFQKR 112
+W P VRD G + +F + R+ Q +QD + E+Q+ D E ++R
Sbjct: 1226 QWEPEKE-NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR 1284
Query: 113 L---------EKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSS 163
E+ ++ EEQ +R+ R+ +EK+LL ++ + ++++QE + +E
Sbjct: 1285 RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE---- 1340
Query: 164 SSAEASGTEEEEEVP 178
E +E EE P
Sbjct: 1341 ---EEQLLQEREEQP 1352
Score = 36.6 bits (83), Expect = 0.013
Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 15/93 (16%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R RRR+ Q + Y + E Q + E+ ++ EE+ +RR++R++ K
Sbjct: 918 REKRRRQEQERQYRE----------EEQLQQEEEQLLREEREKRRRQERERQYRKD---- 963
Query: 143 KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
KL+QK+++ G+ E+ E EEEE
Sbjct: 964 -KKLQQKEEQLLGEEPEKRRRQEREKKYREEEE 995
Score = 35.0 bits (79), Expect = 0.036
Identities = 21/94 (22%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R L R+E +R+ + ++Q+L E Q R ++ + E+Q +R ++ ++ ++++ +
Sbjct: 279 RKLERQELRRERQEEEQ-QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 143 KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+++ EQ+++ +EQ + E+EEE
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Score = 35.0 bits (79), Expect = 0.036
Identities = 19/74 (25%), Positives = 42/74 (56%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
E+Q E Q+R ++ EE+ +RR++R++ KE + L ++ +L+++++ Q +E
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEED 854
Query: 161 GSSSSAEASGTEEE 174
G E ++E+
Sbjct: 855 GLQEDQERRRSQEQ 868
Score = 34.7 bits (78), Expect = 0.048
Identities = 22/96 (22%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
Query: 82 YRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKR--RKKRQKLKEKKL 139
YR ++ + + + + EK++ +K E+ ++ EE+ R R+KR++ + ++
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 140 LAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
KK +L+Q++++ + +E+ E EEEE
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYREEEE 1055
Score = 33.5 bits (75), Expect = 0.11
Identities = 18/70 (25%), Positives = 41/70 (58%), Gaps = 4/70 (5%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
RH R R+++ ++ + E+Q+L + + R K EEQ +R+++ +K +++ +
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDR----KFREEEQQLRRQERERKFLQEEQQLR 1717
Query: 143 KMKLEQKKQE 152
+ +LE+K +E
Sbjct: 1718 RQELERKFRE 1727
Score = 33.5 bits (75), Expect = 0.11
Identities = 23/93 (24%), Positives = 51/93 (54%), Gaps = 4/93 (4%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
+ LRR+E +R+ + + +Q+ + E +R E+ + EE+ + ++ Q+L+ ++ K
Sbjct: 1714 QQLRRQELERK-FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 143 KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
+ EQ +QE + ++Q S ++ EEE+
Sbjct: 1773 FREEEQLRQE---REEQQLRSQESDRKFREEEQ 1802
Score = 33.1 bits (74), Expect = 0.14
Identities = 18/91 (19%), Positives = 46/91 (50%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
R+RE Q ++ E+Q+L E Q+ ++ + EQ +R+++ ++ ++++ ++ +
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
++++E Q + E E+EE
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEE 357
Score = 32.7 bits (73), Expect = 0.18
Identities = 19/99 (19%), Positives = 51/99 (51%), Gaps = 2/99 (2%)
Query: 78 EFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEK 137
E + + L+R E +R + + +Q+L E + + ++ E+ +RR+++ + +++
Sbjct: 595 EERLEQRLKREEVERLEQEER--REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 138 KLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+ +++K E++++ + K + E EEE+E
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Score = 32.7 bits (73), Expect = 0.18
Identities = 24/96 (25%), Positives = 50/96 (52%), Gaps = 3/96 (3%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
+ LRR+E +Q D K + + + ++ E+ +++ +E+ K R + QK++ ++ K
Sbjct: 1538 QQLRRQERGQQRRQDR-DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 143 KMKLEQ--KKQEGPGQPKEQGSSSSAEASGTEEEEE 176
M+ EQ ++QEG Q +++ E +E E
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632
Score = 32.3 bits (72), Expect = 0.24
Identities = 20/83 (24%), Positives = 50/83 (60%), Gaps = 5/83 (6%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEF-QKRLEKNKIAAEEQTAKR----RKKRQKLKEK 137
+ LRR + +R++ + E+++L+ E ++RL++ + +Q KR R++R K +++
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 138 KLLAKKMKLEQKKQEGPGQPKEQ 160
+ L +++K E+ ++ + +EQ
Sbjct: 596 ERLEQRLKREEVERLEQEERREQ 618
Score = 32.0 bits (71), Expect = 0.31
Identities = 20/90 (22%), Positives = 47/90 (52%), Gaps = 2/90 (2%)
Query: 88 REYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLE 147
R+Y+++D + E+ + ++RL++ + E+ ++++ Q L E++ ++ +LE
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077
Query: 148 Q--KKQEGPGQPKEQGSSSSAEASGTEEEE 175
+ +K+E Q +EQ E +E E
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Score = 32.0 bits (71), Expect = 0.31
Identities = 17/79 (21%), Positives = 47/79 (59%), Gaps = 1/79 (1%)
Query: 83 RHLRRREYQRQDYMDAMA-EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLA 141
+ LRR+E +R+ + +Q+L+ +F++ + + +EQ ++ + R+ L+E++L
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 142 KKMKLEQKKQEGPGQPKEQ 160
++ + + ++QE + +E+
Sbjct: 1758 EREEQQLRRQERDRKFREE 1776
Score = 31.6 bits (70), Expect = 0.40
Identities = 17/78 (21%), Positives = 44/78 (56%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
+ LRR + R+ + E+Q+ E Q+R E+ + E+Q + +++R++ + ++ +
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 143 KMKLEQKKQEGPGQPKEQ 160
+ + +Q ++E + +EQ
Sbjct: 358 ERREQQLRREQEEERREQ 375
Score = 31.6 bits (70), Expect = 0.40
Identities = 23/106 (21%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 78 EFHVYRHLRRREYQRQDYMDAMAEKQK--LDAEFQKRLEKNKIAAEEQTAKRRKKRQKL- 134
E + R R R+++ ++ E+++ L+ E Q R E+++ EE+ + ++ Q+L
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 135 ---KEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
+++K L ++ +L +++++ + +E S E EEE+++
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQEL-RSQEPERKFLEEEQQL 1524
Score = 31.6 bits (70), Expect = 0.40
Identities = 23/92 (25%), Positives = 47/92 (51%), Gaps = 5/92 (5%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
R+E RQ AE+Q E +R E+ ++ EE+ +R+++ +KL+E+ + ++ +
Sbjct: 1838 RQERDRQ----YRAEEQFATQEKSRR-EEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892
Query: 147 EQKKQEGPGQPKEQGSSSSAEASGTEEEEEVP 178
++ +Q G + +E GT + VP
Sbjct: 1893 QRHRQVGEIKSQEGKGHGRLLEPGTHQFASVP 1924
Score = 31.2 bits (69), Expect = 0.53
Identities = 35/161 (21%), Positives = 67/161 (41%), Gaps = 16/161 (9%)
Query: 30 EQKLKLERLMKNPD-KAVPIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRR 88
EQ+ +LE+ +K + + + E+ + R PE R + E + LRR
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRRE 650
Query: 89 EYQRQDYMDAMAEK-----QKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKL--------K 135
+ +R++ E+ Q+L E ++ + ++A EEQ R + + ++
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 136 EKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
E K+ +KQEG + +EQ S + +EE
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Score = 31.2 bits (69), Expect = 0.53
Identities = 26/101 (25%), Positives = 50/101 (49%), Gaps = 9/101 (8%)
Query: 86 RRREYQRQDYMDAMAEKQ-KLDAEFQKRLEKNKIAAEEQTAKRRK--------KRQKLKE 136
R R Q Q+ D + E Q + ++ Q+R +K + EE+ +RR + Q KE
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 137 KKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
++LL ++ + Q+++ + +EQ E +EEE++
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943
Score = 31.2 bits (69), Expect = 0.53
Identities = 25/98 (25%), Positives = 51/98 (52%), Gaps = 8/98 (8%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKL---DAEFQKRLEKN-KIAAEEQTAKRRKKRQKLKEKK 138
+ LRR+E +R+ + E+Q+L + E Q R +++ K EEQ R+++ +K +E++
Sbjct: 1381 QRLRRQERERK----FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 139 LLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
++ + E+K E Q +++ E +E E
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Score = 31.2 bits (69), Expect = 0.53
Identities = 20/93 (21%), Positives = 45/93 (48%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R R E RQ+ + Q+ D +F++ + + E+Q +++ + E++ L
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830
Query: 143 KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
+ + ++ +QE Q + + ++ E S EE+E
Sbjct: 1831 EEQEQRLRQERDRQYRAEEQFATQEKSRREEQE 1863
Score = 30.8 bits (68), Expect = 0.69
Identities = 14/68 (20%), Positives = 39/68 (57%)
Query: 85 LRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKM 144
L+R E + + ++ K D E ++R K+ EE+ ++ ++ Q+L+ ++ ++
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 145 KLEQKKQE 152
+L+++++E
Sbjct: 518 RLKRQEEE 525
Score = 30.8 bits (68), Expect = 0.69
Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 83 RHLRRREYQRQDYMDAMAEK---QKLDAEFQKRLEKNKIAAE------EQTAKRRKKRQK 133
+ L+R + +R+D + E+ Q+L E ++RLE+ E E+ ++R KR++
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Query: 134 LKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+E++ + +K E++++ Q + + + EEEEE
Sbjct: 625 PEEER-RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Score = 30.8 bits (68), Expect = 0.69
Identities = 26/105 (24%), Positives = 53/105 (50%), Gaps = 13/105 (12%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRL--------EKNKIAAEEQTAKRRKK---R 131
R RR +Q++D E+++L+ E QK E+ ++ EE+ KRR++ R
Sbjct: 1279 REQERRRWQQRDRH--FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 132 QKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+ +E++LL ++ + ++QE + +E+ + EEE+
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Score = 30.4 bits (67), Expect = 0.90
Identities = 24/105 (22%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKL-----------DAEFQKRLEKNKIAAEEQTAKRR-KK 130
R L+ RE Q ++ + E+++L + E Q R E+ EEQ + +K
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 131 RQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
R++ + ++ ++ +L+Q++++ + +E+ E EEEE
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145
Score = 30.0 bits (66), Expect = 1.2
Identities = 22/103 (21%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 77 GEFHVYRHLRRREYQRQ-DYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLK 135
G+ + + R+ E QR+ + D E++ QKR E+ + AE + ++ +K+++L+
Sbjct: 105 GKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE--EQSEKQERLE 162
Query: 136 EKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEVP 178
++ + +L +++QE + + + ++ E EE P
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205
Score = 29.6 bits (65), Expect = 1.5
Identities = 16/83 (19%), Positives = 45/83 (54%), Gaps = 2/83 (2%)
Query: 85 LRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKM 144
LR+ E + Q+ + + + E ++LE+ ++ E Q + +++Q+L+ ++ L +K
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ--EEEQQQQRLRREQQLRRKQ 310
Query: 145 KLEQKKQEGPGQPKEQGSSSSAE 167
+ E+++Q+ + +++ E
Sbjct: 311 EEERREQQEERREQQERREQQEE 333
Score = 29.6 bits (65), Expect = 1.5
Identities = 19/90 (21%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRR--KKRQKLKEKKLLAKKM 144
RRE + + + +Q+L E Q R E+ ++ E+Q + + ++ Q+L+ ++ L ++
Sbjct: 365 RREQEEERREQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLRREQQLRREQQLRREQ 423
Query: 145 KLEQKKQEGPGQPKEQGSSSSAEASGTEEE 174
+L ++++E + K + +EE
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEE 453
Score = 29.6 bits (65), Expect = 1.5
Identities = 18/80 (22%), Positives = 47/80 (58%), Gaps = 5/80 (6%)
Query: 83 RHLRRREYQRQD--YMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLL 140
R LR E Q+++ ++ EK++ + ++R ++ + EE+ +RR++ Q+L+E++
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE-- 853
Query: 141 AKKMKLEQKKQEGPGQPKEQ 160
++ +Q+++ Q ++Q
Sbjct: 854 -DGLQEDQERRRSQEQRRDQ 872
Score = 29.6 bits (65), Expect = 1.5
Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 5/96 (5%)
Query: 86 RRRE--YQRQDYMDAMAEKQKLDAEFQKRL---EKNKIAAEEQTAKRRKKRQKLKEKKLL 140
RRR Y + + + ++Q+L E ++ L E+ K +EQ + R++ Q +E++ L
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
++ + ++++QE Q ++ E EE E
Sbjct: 944 LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Score = 29.6 bits (65), Expect = 1.5
Identities = 23/93 (24%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRL--EKNKIAAEEQTAKRRKKRQKLKEKKLLAKK 143
RR+E +RQ E+++L E ++ L E+ K +E + R++ + +E++ L ++
Sbjct: 1102 RRQERERQ-----CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 144 MKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
++++QE Q +E+ E EE+E
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQE 1189
Score = 29.6 bits (65), Expect = 1.5
Identities = 20/95 (21%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 82 YRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLA 141
YR + E R + + +Q+ D +F++ E+ + EEQ + ++ +K +E++
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREE-EQLRQEREEQQLRSQESDRKFREEE--- 1801
Query: 142 KKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+L Q+++E +P+++ E + EE+
Sbjct: 1802 ---QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Score = 29.3 bits (64), Expect = 2.0
Identities = 20/97 (20%), Positives = 50/97 (51%), Gaps = 5/97 (5%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKL--L 140
+ LRR + +R++ ++Q+ + Q+RL + EQ +R + ++ +EK+L
Sbjct: 505 QQLRREQEERREQR---LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
++ +L+++++E Q ++ + E+EE +
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Score = 29.3 bits (64), Expect = 2.0
Identities = 17/79 (21%), Positives = 46/79 (58%), Gaps = 4/79 (5%)
Query: 78 EFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKN-KIAAEEQTAKRRKKRQ---K 133
+F + RR+ Q + +M+ + ++ + + Q R E++ K +EQ + R+++Q +
Sbjct: 1580 KFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Query: 134 LKEKKLLAKKMKLEQKKQE 152
+++K L ++ +L ++++E
Sbjct: 1640 ERDRKFLEEEPQLRRQERE 1658
Score = 29.3 bits (64), Expect = 2.0
Identities = 24/92 (26%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKR-QKLKEKKLLA 141
R R E RQ+ + Q+ D ++ R E+ ++ EEQ + R++R ++ + ++ A
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGKY--RWEEEQLQLEEQEQRLRQERDRQYRAEEQFA 1852
Query: 142 KKMKLEQKKQEGPGQPKEQGSSSSAEASGTEE 173
+ K +++QE Q +EQ E EE
Sbjct: 1853 TQEKSRREEQE-LWQEEEQKRRQERERKLREE 1883
Score = 28.1 bits (61), Expect = 4.5
Identities = 18/96 (18%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLD-AEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLA 141
RH ++ E +R++ ++++ D + ++ E+++ +Q KR ++ ++ + L
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492
Query: 142 KKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
++ + EQ+++ +EQ EEEE +
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERL 528
Score = 28.1 bits (61), Expect = 4.5
Identities = 19/93 (20%), Positives = 46/93 (49%), Gaps = 1/93 (1%)
Query: 86 RRREYQRQDYMDAMAEKQKLDA-EFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKM 144
RR+ +R+ + + E+++L E ++L++ + +E +RR + Q+ +K +
Sbjct: 821 RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880
Query: 145 KLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
+ ++++ +P Q + EEEEE+
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Score = 28.1 bits (61), Expect = 4.5
Identities = 10/50 (20%), Positives = 31/50 (62%)
Query: 88 REYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEK 137
R+Y+ ++ + E+ + + ++R E+ + EE+ +R+K++Q+ +++
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Score = 28.1 bits (61), Expect = 4.5
Identities = 24/107 (22%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 78 EFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQ----KRLEKNKIAAEEQTAKRRKKRQK 133
E + R R + +RQ+ E+++L E + +R E+++ EE+ + + R+
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKF 1376
Query: 134 LKEKKLL---AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
L+E++ L ++ K +++Q+ Q +EQ + EEE+++
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Score = 28.1 bits (61), Expect = 4.5
Identities = 16/82 (19%), Positives = 46/82 (56%), Gaps = 5/82 (6%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKL----KEKK 138
+ L R++ QR+ ++ + ++ + Q+R ++++ EE+ ++ ++ Q+L +++K
Sbjct: 1522 QQLHRQQRQRK-FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 139 LLAKKMKLEQKKQEGPGQPKEQ 160
++ K+ +++QE EQ
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQ 1602
Score = 27.7 bits (60), Expect = 5.8
Identities = 16/68 (23%), Positives = 37/68 (54%), Gaps = 3/68 (4%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRR---KKRQKLKEKKLLAKK 143
RRE Q + + +Q+ E Q R E+ + E+Q + + ++ Q+L+ ++ L ++
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 144 MKLEQKKQ 151
+L +++Q
Sbjct: 387 QQLRREQQ 394
Score = 27.7 bits (60), Expect = 5.8
Identities = 14/67 (20%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRR--KKRQKLKEKKLLAKKM 144
RRE Q + + +Q+L E ++ + ++ E+Q + + ++ Q+L+ ++ L ++
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 145 KLEQKKQ 151
+L +++Q
Sbjct: 406 QLRREQQ 412
Score = 27.7 bits (60), Expect = 5.8
Identities = 16/74 (21%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
RRE Q + + E++ E ++RL++ ++ +E+Q + +++R++ K+ K+++
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQ-RLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 147 EQKKQEGPGQPKEQ 160
E+++Q + +E+
Sbjct: 561 ERREQRLKREQEER 574
Score = 27.7 bits (60), Expect = 5.8
Identities = 19/87 (21%), Positives = 45/87 (51%), Gaps = 13/87 (14%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKE------ 136
R R R+++ ++ + E+Q+L + + R K EEQ +R+++ +K +E
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDR----KFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 137 ---KKLLAKKMKLEQKKQEGPGQPKEQ 160
+K L ++ +L +++++ +EQ
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQ 1538
Score = 27.3 bits (59), Expect = 7.6
Identities = 23/135 (17%), Positives = 56/135 (41%), Gaps = 3/135 (2%)
Query: 44 KAVPIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYM---DAMA 100
K + K E P+ R++ E R R+ E Q+Q + +
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
KQ+ + Q+ + + EQ +RR+++ + ++++ ++++ EQ+++ Q + +
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 161 GSSSSAEASGTEEEE 175
E E++
Sbjct: 368 QEEERREQQLRREQQ 382
Score = 27.3 bits (59), Expect = 7.6
Identities = 22/98 (22%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLE----KNKIAAEEQTAKRRKKRQKLKEKK 138
+ LRR + R++ + +Q+L E Q R E +++ E++ ++R KR++ + +
Sbjct: 399 QQLRREQQLRREQQ--LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 139 LLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
L ++ + E+ +QE Q ++ + EEE
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Score = 27.3 bits (59), Expect = 7.6
Identities = 18/95 (18%), Positives = 46/95 (48%), Gaps = 6/95 (6%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEK------KLL 140
+R+ + + + +Q+L E ++R E+ EE+ ++ ++ Q+LK + +LL
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
++ + Q++ + + + + E E+EE
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Score = 27.3 bits (59), Expect = 7.6
Identities = 21/99 (21%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 86 RRREYQRQDYMDAMAEK--QKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKK 143
+RR++ Q + +E+ Q+L A R ++ + E+ +R ++ +E+K ++
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 144 MKLEQKK------QEGPGQPKEQGSSSSAEASGTEEEEE 176
+ E++K +E Q +E+ E G +E++E
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Score = 26.9 bits (58), Expect = 9.9
Identities = 18/89 (20%), Positives = 47/89 (52%), Gaps = 11/89 (12%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNK------IAAEEQTAKRRKKRQKL-- 134
+ LRR + R++ + E++ ++RL++ + + EE+T + ++R+K
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 135 ---KEKKLLAKKMKLEQKKQEGPGQPKEQ 160
+E++ + +KLE++++ + +EQ
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQ 505
Score = 26.9 bits (58), Expect = 9.9
Identities = 11/69 (15%), Positives = 42/69 (60%), Gaps = 2/69 (2%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKK-- 143
RR + +R++ ++++ + +++ E+ ++ ++ ++ ++ Q+ + ++LL ++
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 144 MKLEQKKQE 152
+LEQ+++E
Sbjct: 556 KRLEQERRE 564
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 39.7 bits (91), Expect = 0.001
Identities = 44/177 (24%), Positives = 80/177 (45%), Gaps = 16/177 (9%)
Query: 10 RPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVR---D 66
R P K E T V + AE + M + P P AP P P V
Sbjct: 401 RAPLVKVEEAT-VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSS 459
Query: 67 VMGSSAG----AGSGEFHVYRHL---RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIA 119
+ +SA AG+ + L +RR + Q + +++ + E QKR E +
Sbjct: 460 TVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRV 519
Query: 120 AEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
AEE+T +R ++ ++L+ ++ K+ +L+++ +E + +E+ AE + ++EEE
Sbjct: 520 AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREE-----AERAQRQKEEE 571
Score = 33.1 bits (74), Expect = 0.14
Identities = 19/68 (27%), Positives = 38/68 (55%), Gaps = 1/68 (1%)
Query: 85 LRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKM 144
L R E RQ Y + E++K E Q++ E+ + AA E+ ++R + K + + ++ + M
Sbjct: 89 LEREERARQHYEKHLEERKK-RLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTM 147
Query: 145 KLEQKKQE 152
+ QK ++
Sbjct: 148 ERSQKPKQ 155
Score = 30.4 bits (67), Expect = 0.90
Identities = 31/138 (22%), Positives = 63/138 (45%), Gaps = 11/138 (7%)
Query: 14 PKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMGSSAG 73
P++ + L + A EQ+ K ER + ++ +K E A R E S
Sbjct: 476 PEEATRLLAEKRRLAREQREKEERERREQEELER--QKREELAQRVAEERTTRREEESRR 533
Query: 74 AGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQK 133
+ + R +E Q Q + A +++ +AE +R ++ + E+ + R++R+K
Sbjct: 534 LEAEQ------AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK 587
Query: 134 ---LKEKKLLAKKMKLEQ 148
+E++ L +K +LE+
Sbjct: 588 HFQREEQERLERKKRLEE 605
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 39.3 bits (90), Expect = 0.002
Identities = 24/94 (25%), Positives = 46/94 (48%), Gaps = 6/94 (6%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R +R+E + ++ EK+K + + + R E+ K ++ + K+R++ K KK K
Sbjct: 82 REKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKK 141
Query: 143 KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
K + E+K++ KE+G +EE E
Sbjct: 142 KRRKERKRE------KERGKRERKRKKRKKEERE 169
Score = 38.1 bits (87), Expect = 0.004
Identities = 23/94 (24%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R R++E ++++ ++K E ++R +NK E + KRRKK+++ KE+K +
Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR-KERKREKE 152
Query: 143 KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+ K E+K+++ + +E+ + + E E +
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNRKERKKERERK 186
Score = 35.4 bits (80), Expect = 0.028
Identities = 18/67 (26%), Positives = 39/67 (58%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+RR+ +R+ E+ K + + +KR ++ + E+ K RKK ++ KE++ K+ K
Sbjct: 137 KRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERK 196
Query: 146 LEQKKQE 152
E++K++
Sbjct: 197 KERRKKK 203
Score = 32.7 bits (73), Expect = 0.18
Identities = 19/90 (21%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
R++E + ++ EK++ +K +K K E + RK++++ K++K +K +
Sbjct: 36 RKKERREREKRKREREKERKRERGKKEKKKRK-KRERGKERERKRKEREKQRKERREKER 94
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
++KK++ + K++G + +E E
Sbjct: 95 RKRKKEKKKRERKQRGRRERKKKKERKERE 124
Score = 32.7 bits (73), Expect = 0.18
Identities = 20/93 (21%), Positives = 49/93 (52%), Gaps = 3/93 (3%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R R+RE +++ + +K+K + ++R ++ + +E+ +R+++R+K + K+ K
Sbjct: 43 REKRKREREKERKRER-GKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKR--KK 99
Query: 143 KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
+ K ++KQ G + K++ E + E
Sbjct: 100 EKKKRERKQRGRRERKKKKERKERERENKQRRE 132
Score = 32.7 bits (73), Expect = 0.18
Identities = 20/74 (27%), Positives = 40/74 (54%), Gaps = 3/74 (4%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
R QR++ K+K E ++ E+ K E+ K+RKK ++ K+++ K+ K
Sbjct: 125 RENKQRRERKRKKRRKKKRRKERKREKERGK---RERKRKKRKKEEREKKRERNRKERKK 181
Query: 147 EQKKQEGPGQPKEQ 160
E++++E + KE+
Sbjct: 182 ERERKERRERKKER 195
Score = 32.3 bits (72), Expect = 0.24
Identities = 24/100 (24%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 80 HVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKL 139
H+ + +RE +R+ EK+K + E +++ E+ K + K+RKKR++ KE++
Sbjct: 24 HISKPCTQRESERKKERRER-EKRKREREKERKRERGK-----KEKKKRKKRERGKERER 77
Query: 140 LAK---KMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
K K + E++++E + KE+ + E +++
Sbjct: 78 KRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKK 117
Score = 31.2 bits (69), Expect = 0.53
Identities = 15/65 (23%), Positives = 36/65 (55%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
RR+E +R+ K+K + ++ ++ + E + + RK+R++ K+++ ++ K
Sbjct: 143 RRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK 202
Query: 146 LEQKK 150
E+KK
Sbjct: 203 KERKK 207
Score = 31.2 bits (69), Expect = 0.53
Identities = 19/70 (27%), Positives = 38/70 (54%), Gaps = 1/70 (1%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R R+RE +R + +K+K + +KR K +E+ K R++R+K ++K+ K
Sbjct: 144 RKERKREKERGK-RERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK 202
Query: 143 KMKLEQKKQE 152
K + + +K +
Sbjct: 203 KERKKDRKTD 212
Score = 30.8 bits (68), Expect = 0.69
Identities = 18/90 (20%), Positives = 47/90 (52%), Gaps = 2/90 (2%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
R+E +R++ E+++ +KR ++ K E +R++K++K +E++ ++ +
Sbjct: 120 RKERERENKQ--RRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK 177
Query: 147 EQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
E+KK+ + +E+ E +E ++
Sbjct: 178 ERKKERERKERRERKKERKKERRKKKERKK 207
Score = 29.6 bits (65), Expect = 1.5
Identities = 18/66 (27%), Positives = 40/66 (60%), Gaps = 2/66 (3%)
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
R++ +++ + EK++ E +KR ++ K E++ + RK+R+K +E+K ++ K
Sbjct: 135 RKKRRKKKRRKERKREKERGKRE-RKRKKRKKEEREKKRERNRKERKKERERK-ERRERK 192
Query: 146 LEQKKQ 151
E+KK+
Sbjct: 193 KERKKE 198
Score = 26.9 bits (58), Expect = 9.9
Identities = 20/93 (21%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 86 RRREYQRQDYMDAMAEKQ-KLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKM 144
+RRE +R+ K+ K + E KR K K +E+ K+R++ KE+K ++
Sbjct: 129 QRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERN--RKERKKERERK 186
Query: 145 KLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
+ ++K+E + +++ + + + +V
Sbjct: 187 ERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 39.3 bits (90), Expect = 0.002
Identities = 38/177 (21%), Positives = 72/177 (40%), Gaps = 9/177 (5%)
Query: 3 SPAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPE 62
SP + P K P+ + E K + ++P P K PE
Sbjct: 738 SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797
Query: 63 FVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEE 122
+ + A A E + ++E + + ++ E K+ E+ K A
Sbjct: 798 KAKSPLKEDAKAPEKE------IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP 851
Query: 123 QTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEVPS 179
+T +++ +++ KK A K K+E+KK+ +PKE S A+ E++++VP+
Sbjct: 852 KTEEKKDSKKEEAPKK-EAPKPKVEEKKEPAVEKPKE--SKVEAKKEEAEDKKKVPT 905
Score = 35.0 bits (79), Expect = 0.036
Identities = 40/186 (21%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 3 SPAASSVRPPRPKKEPQTLVIPKNA-AEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPP 61
SP V+ P K P + ++A A E+++ + +K+P K P+++ PP
Sbjct: 787 SPVKEEVKSPEKAKSP----LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVK--VKEPPK 840
Query: 62 EFVRDVMGSSAGAGSGEFHVYRHLRRREYQR---QDYMDAMAEK---QKLDAEFQKRLEK 115
+ + ++ + ++E + ++ + EK K++A+ ++ +K
Sbjct: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
Query: 116 NKIAAEEQTAKRR---KKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTE 172
K+ E+ A + K+ K KEK +AKK + K +E P +P E+ ++ + E
Sbjct: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE-PSKPAEKKEAAPEKKDTKE 959
Query: 173 EEEEVP 178
E+ + P
Sbjct: 960 EKAKKP 965
Score = 32.3 bits (72), Expect = 0.24
Identities = 41/178 (23%), Positives = 70/178 (39%), Gaps = 20/178 (11%)
Query: 3 SPAASSVRPPR---PKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRP 59
+PA R P P+K + + E+ K L+ K P+K +P E++ +P
Sbjct: 768 TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK--SPVK 825
Query: 60 PPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIA 119
E ++V V ++ E ++ EK+ E + E K
Sbjct: 826 EEEKPQEVK------------VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 120 AEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEEV 177
EE K+ +K KE K+ AKK + E KK+ + + E + +E+ EV
Sbjct: 874 VEE---KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928
Score = 30.0 bits (66), Expect = 1.2
Identities = 20/68 (29%), Positives = 33/68 (48%), Gaps = 11/68 (16%)
Query: 111 KRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASG 170
++ EK + EEQT + + + +E++ E K++EG KE+ EA G
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEK-------EAKEEEG----KEEEGGEEEEAEG 496
Query: 171 TEEEEEVP 178
EEE + P
Sbjct: 497 GEEETKSP 504
>gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 170
Score = 38.9 bits (89), Expect = 0.003
Identities = 18/63 (28%), Positives = 40/63 (63%)
Query: 91 QRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKK 150
QR++ + EK+K + +K+ +K K +++ K++KKR++ +++K KK + ++KK
Sbjct: 101 QREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKK 160
Query: 151 QEG 153
+ G
Sbjct: 161 KTG 163
Score = 37.0 bits (84), Expect = 0.010
Identities = 17/66 (25%), Positives = 42/66 (63%)
Query: 102 KQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQG 161
++K + E +K+ +K K +++ K++KK++K K+KK +K K ++K+++ + K++
Sbjct: 103 EEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKT 162
Query: 162 SSSSAE 167
+ A+
Sbjct: 163 GNEGAK 168
Score = 34.7 bits (78), Expect = 0.048
Identities = 16/65 (24%), Positives = 40/65 (61%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
E++K + +K+ +K K +++ K++KK++K K+KK K+ + ++K++ + K+
Sbjct: 103 EEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKT 162
Query: 161 GSSSS 165
G+ +
Sbjct: 163 GNEGA 167
Score = 34.7 bits (78), Expect = 0.048
Identities = 16/63 (25%), Positives = 37/63 (58%)
Query: 110 QKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEAS 169
+++ EK K +++ K++KK++K K+KK KK K ++K++ + +++ + +
Sbjct: 103 EEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKT 162
Query: 170 GTE 172
G E
Sbjct: 163 GNE 165
Score = 34.3 bits (77), Expect = 0.062
Identities = 19/71 (26%), Positives = 42/71 (59%), Gaps = 3/71 (4%)
Query: 85 LRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKM 144
L +RE +++ + +K+K + +K+ +K K +++ KR++KR++ +++K KK
Sbjct: 99 LPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRK---KKR 155
Query: 145 KLEQKKQEGPG 155
K ++KK G
Sbjct: 156 KKKKKKTGNEG 166
Score = 32.7 bits (73), Expect = 0.18
Identities = 18/68 (26%), Positives = 41/68 (60%), Gaps = 4/68 (5%)
Query: 101 EKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
EK++ + E +K+ +K K ++ K++KK++K K+KK +K K ++K++ + K++
Sbjct: 104 EKKEKEKEKKKKKKKKK----KKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKK 159
Query: 161 GSSSSAEA 168
+ + A
Sbjct: 160 KKTGNEGA 167
Score = 30.8 bits (68), Expect = 0.69
Identities = 16/64 (25%), Positives = 36/64 (56%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
++E +++ +K+K + +K+ +K K +++ KR++KR++ K++K KK
Sbjct: 105 KKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKTGN 164
Query: 147 EQKK 150
E K
Sbjct: 165 EGAK 168
Score = 28.1 bits (61), Expect = 4.5
Identities = 15/55 (27%), Positives = 31/55 (56%)
Query: 106 DAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ 160
DA L + + E+ ++ K+++K K+KK KK K ++KK++ + K++
Sbjct: 87 DAGPSLHLPLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKR 141
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 38.9 bits (89), Expect = 0.003
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 2/84 (2%)
Query: 91 QRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAK-RRKKRQKLKEKKLLAKKMKLEQK 149
+RQ D++ ++D+E K K + + EQ K R++ RQK K++ + KLEQ
Sbjct: 1717 KRQQQQDSIDPSSRIDSELFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQV 1776
Query: 150 KQEGPGQPKEQ-GSSSSAEASGTE 172
K E Q ++Q GS SG++
Sbjct: 1777 KNEQQQQQQQQFGSQHLLVQSGSD 1800
Score = 27.7 bits (60), Expect = 5.8
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 7/62 (11%)
Query: 91 QRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKK 150
QR+ Y + + E Q+L QK LE EQ RK ++ L K+ AKK E +
Sbjct: 3176 QRKQYEEWLQETQQLLQMQQKYLE-------EQIGAHRKSKKALSAKQRTAKKAGREFPE 3228
Query: 151 QE 152
++
Sbjct: 3229 ED 3230
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 38.9 bits (89), Expect = 0.003
Identities = 40/167 (23%), Positives = 73/167 (43%), Gaps = 16/167 (9%)
Query: 10 RPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMG 69
+PP+ + + + +V +++ +K E +K VP E+ S + DV
Sbjct: 576 KPPKVESKEKVMV-----KKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKP 630
Query: 70 SSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRK 129
+A E V + + + +++ EK+K E K+ +K I EE+ K
Sbjct: 631 KAAK----EKTVKKETKVKPEDKKE------EKEKPKKEVAKKEDKTPIKKEEKPKKEEV 680
Query: 130 KRQKLKE-KKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
K++ KE KK K+ K E KK+ P + K++ + EE+E
Sbjct: 681 KKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKE 727
Score = 36.6 bits (83), Expect = 0.013
Identities = 36/177 (20%), Positives = 76/177 (42%), Gaps = 6/177 (3%)
Query: 1 MASPAASSVRPPRPKKEP---QTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAP 57
+A A+ V+P K++ +T V P++ EE++ + + K DK PI ++
Sbjct: 620 VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKT-PIKKEEKPKKE 678
Query: 58 RPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNK 117
E +++ E V + +E +++ + E +K + E +K ++K
Sbjct: 679 EVKKEVKKEIKKEEKKEPKKE--VKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP 736
Query: 118 IAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEE 174
A++ + + ++ K + KK + +K G+PKE+G + G E
Sbjct: 737 KDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAE 793
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 38.9 bits (89), Expect = 0.003
Identities = 25/93 (26%), Positives = 52/93 (55%), Gaps = 4/93 (4%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRK--KRQKLKEKKLL 140
R RRE +R++ E+++ AE ++R E+ ++ AE + +R K + QK + ++ L
Sbjct: 698 REQERREQERRE--QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQREL 755
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEE 173
+K K E++++ Q +E+ + EA+G +
Sbjct: 756 EEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
Score = 34.3 bits (77), Expect = 0.062
Identities = 34/151 (22%), Positives = 72/151 (47%), Gaps = 10/151 (6%)
Query: 31 QKLKLERLMKNPDKAVPIPEKMSEW-APRPPPEFVRDVMGSSAGAGSGEFHVYRH---LR 86
+K K ERL + K +KM E A R E R + E RH L+
Sbjct: 611 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ-----EEEERRHQELLQ 665
Query: 87 RREYQRQDYMDAMAEKQKL-DAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+++ + Q+ + AE ++L + Q+R E+ + E + +RR++ ++ +E++L ++ +
Sbjct: 666 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
EQ++ + + +E+ + + + E E
Sbjct: 726 REQERLQAERELQEREKALRLQKEQLQRELE 756
Score = 34.3 bits (77), Expect = 0.062
Identities = 23/96 (23%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R +RE +R++ E+++ + Q+R E+ + AE++ + +++ Q +E + K
Sbjct: 683 RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREK 742
Query: 143 KMKL--EQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
++L EQ ++E + K++ AE EE+E+
Sbjct: 743 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
Score = 33.9 bits (76), Expect = 0.081
Identities = 21/66 (31%), Positives = 40/66 (60%), Gaps = 7/66 (10%)
Query: 84 HLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKK 143
+LRR+E Q +QK++ + ++RLE+ K+ EE+ K + R+++++ K KK
Sbjct: 544 NLRRKEEAEQ------LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK-EEKK 596
Query: 144 MKLEQK 149
++EQK
Sbjct: 597 KQIEQK 602
Score = 32.0 bits (71), Expect = 0.31
Identities = 23/89 (25%), Positives = 46/89 (51%), Gaps = 4/89 (4%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
+RE + + + A +++ E +K++E+ +E+T K +++R L E+K AKK
Sbjct: 573 KREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEER--LAEEK--AKKKAA 628
Query: 147 EQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
+K +E + K++ + EEEE
Sbjct: 629 AKKMEEVEARRKQEEEARRLRWLQQEEEE 657
Score = 28.5 bits (62), Expect = 3.4
Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 11/156 (7%)
Query: 29 EEQKLKLERLMKNPDKAVPIPEKMSEWAPRPPPEFVRDVMGSS---AGAGSGEFHVYRHL 85
EEQ L+ E L K P S+ RP F+ V + + + +
Sbjct: 462 EEQHLEDEELQPPRSKTPSSPCPASK-VVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFI 520
Query: 86 RRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAE---EQTAKRRKKRQKLKE----KK 138
+R R D + EK++ E +R E+ + E+ +RR + KLK +K
Sbjct: 521 KRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRK 580
Query: 139 LLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEE 174
+L + ++EQ K+E Q +++ + + +EE
Sbjct: 581 VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE 616
Score = 28.5 bits (62), Expect = 3.4
Identities = 24/96 (25%), Positives = 48/96 (50%), Gaps = 7/96 (7%)
Query: 87 RREYQRQDYMDAMAEKQK--LDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKL----L 140
R+ Q ++ ++ M E++K ++ +F + EK + A EE+ A+ + K+ K KK+
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK-KAAAKKMEEVEA 637
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+K + E ++ Q +E+ EEE+E
Sbjct: 638 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE 673
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 38.9 bits (89), Expect = 0.003
Identities = 25/93 (26%), Positives = 52/93 (55%), Gaps = 4/93 (4%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRK--KRQKLKEKKLL 140
R RRE +R++ E+++ AE ++R E+ ++ AE + +R K + QK + ++ L
Sbjct: 694 REQERREQERRE--QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQREL 751
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEE 173
+K K E++++ Q +E+ + EA+G +
Sbjct: 752 EEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
Score = 34.3 bits (77), Expect = 0.062
Identities = 34/151 (22%), Positives = 72/151 (47%), Gaps = 10/151 (6%)
Query: 31 QKLKLERLMKNPDKAVPIPEKMSEW-APRPPPEFVRDVMGSSAGAGSGEFHVYRH---LR 86
+K K ERL + K +KM E A R E R + E RH L+
Sbjct: 607 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ-----EEEERRHQELLQ 661
Query: 87 RREYQRQDYMDAMAEKQKL-DAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMK 145
+++ + Q+ + AE ++L + Q+R E+ + E + +RR++ ++ +E++L ++ +
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
Query: 146 LEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
EQ++ + + +E+ + + + E E
Sbjct: 722 REQERLQAERELQEREKALRLQKEQLQRELE 752
Score = 34.3 bits (77), Expect = 0.062
Identities = 23/96 (23%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
Query: 83 RHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAK 142
R +RE +R++ E+++ + Q+R E+ + AE++ + +++ Q +E + K
Sbjct: 679 RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREK 738
Query: 143 KMKL--EQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
++L EQ ++E + K++ AE EE+E+
Sbjct: 739 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
Score = 33.9 bits (76), Expect = 0.081
Identities = 21/66 (31%), Positives = 40/66 (60%), Gaps = 7/66 (10%)
Query: 84 HLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKK 143
+LRR+E Q +QK++ + ++RLE+ K+ EE+ K + R+++++ K KK
Sbjct: 540 NLRRKEEAEQ------LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK-EEKK 592
Query: 144 MKLEQK 149
++EQK
Sbjct: 593 KQIEQK 598
Score = 32.0 bits (71), Expect = 0.31
Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 87 RREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKL 146
+RE + + + A +++ E +K++E+ +E+T K K ++L E+K AKK
Sbjct: 569 KREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK--AKEERLAEEK--AKKKAA 624
Query: 147 EQKKQEGPGQPKEQGSSSSAEASGTEEEE 175
+K +E + K++ + EEEE
Sbjct: 625 AKKMEEVEARRKQEEEARRLRWLQQEEEE 653
Score = 28.5 bits (62), Expect = 3.4
Identities = 24/96 (25%), Positives = 48/96 (50%), Gaps = 7/96 (7%)
Query: 87 RREYQRQDYMDAMAEKQK--LDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKL----L 140
R+ Q ++ ++ M E++K ++ +F + EK + A EE+ A+ + K+ K KK+
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK-KAAAKKMEEVEA 633
Query: 141 AKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176
+K + E ++ Q +E+ EEE+E
Sbjct: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE 669
Score = 27.7 bits (60), Expect = 5.8
Identities = 21/82 (25%), Positives = 43/82 (52%), Gaps = 11/82 (13%)
Query: 101 EKQKLD----AEFQKRLEKNKIAAEEQTAKRRKKRQKLKE----KKLLAKKMKLEQKKQE 152
E+Q+L+ E ++L + K+ E+ +RR + KLK +K+L + ++EQ K+E
Sbjct: 534 ERQRLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 153 GPGQPKEQGSSSSAEASGTEEE 174
Q +++ + + +EE
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEE 612
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,632,961
Number of Sequences: 37866
Number of extensions: 458728
Number of successful extensions: 8582
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 403
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 4216
Number of HSP's gapped (non-prelim): 3543
length of query: 184
length of database: 18,247,518
effective HSP length: 96
effective length of query: 88
effective length of database: 14,612,382
effective search space: 1285889616
effective search space used: 1285889616
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.