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Search of human proteins with 13375727
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13375727 acyl-CoA synthetase short-chain family member 3
[Homo sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13375727 acyl-CoA synthetase short-chain family member 3 [Hom... 1407 0.0
gi|28416953 acyl-CoA synthetase short-chain family member 1 [Hom... 371 e-102
gi|8923896 acyl-CoA synthetase short-chain family member 2 isofo... 363 e-100
gi|253970489 acyl-CoA synthetase short-chain family member 2 iso... 360 3e-99
gi|115511026 acyl-CoA synthetase medium-chain family member 1 [H... 167 2e-41
gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Ho... 166 7e-41
gi|42544132 SA hypertension-associated homolog isoform 1 [Homo s... 162 1e-39
gi|122937307 acyl-CoA synthetase medium-chain family member 4 [H... 161 2e-39
gi|58082049 acyl-CoA synthetase medium-chain family member 2A [H... 159 6e-39
gi|157311624 acyl-CoA synthetase medium-chain family member 2B [... 157 4e-38
gi|157311622 acyl-CoA synthetase medium-chain family member 2B [... 157 4e-38
gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase AC... 139 7e-33
gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase AC... 139 7e-33
gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens] 119 7e-27
gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Ho... 91 3e-18
gi|42544134 SA hypertension-associated homolog isoform 2 [Homo s... 75 3e-13
gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens] 70 8e-12
gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens] 70 8e-12
gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens] 69 2e-11
gi|62865631 solute carrier family 27 (fatty acid transporter), m... 58 3e-08
gi|13325055 solute carrier family 27 (fatty acid transporter), m... 58 3e-08
gi|40807357 solute carrier family 27 (fatty acid transporter), m... 56 1e-07
gi|27477105 lipidosin [Homo sapiens] 42 0.001
gi|227499619 solute carrier family 27 (fatty acid transporter), ... 39 0.016
gi|38524616 solute carrier family 27, member 1 [Homo sapiens] 36 0.14
gi|148536864 SWI/SNF-related matrix-associated actin-dependent r... 36 0.14
gi|45580730 aminoadipate-semialdehyde dehydrogenase [Homo sapiens] 35 0.23
gi|13325057 solute carrier family 27 (fatty acid transporter), m... 34 0.51
gi|24234699 keratin 19 [Homo sapiens] 33 0.88
gi|4557809 ornithine aminotransferase precursor [Homo sapiens] 33 1.1
>gi|13375727 acyl-CoA synthetase short-chain family member 3 [Homo
sapiens]
Length = 686
Score = 1407 bits (3641), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGS 60
MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGS
Sbjct: 1 MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGS 60
Query: 61 EYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRH 120
EYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRH
Sbjct: 61 EYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRH 120
Query: 121 IENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQ 180
IENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQ
Sbjct: 121 IENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQ 180
Query: 181 AMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEE 240
AMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEE
Sbjct: 181 AMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEE 240
Query: 241 ALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTS 300
ALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTS
Sbjct: 241 ALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTS 300
Query: 301 GTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGN 360
GTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGN
Sbjct: 301 GTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGN 360
Query: 361 TTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKT 420
TTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKT
Sbjct: 361 TTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKT 420
Query: 421 LFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVP 480
LFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVP
Sbjct: 421 LFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVP 480
Query: 481 GYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDA 540
GYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDA
Sbjct: 481 GYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDA 540
Query: 541 GYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLA 600
GYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLA
Sbjct: 541 GYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLA 600
Query: 601 LCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVN 660
LCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVN
Sbjct: 601 LCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVN 660
Query: 661 GKPYKITSTIEDPSIFGHVEEMLKQA 686
GKPYKITSTIEDPSIFGHVEEMLKQA
Sbjct: 661 GKPYKITSTIEDPSIFGHVEEMLKQA 686
>gi|28416953 acyl-CoA synthetase short-chain family member 1 [Homo
sapiens]
Length = 689
Score = 371 bits (953), Expect = e-102
Identities = 236/684 (34%), Positives = 361/684 (52%), Gaps = 39/684 (5%)
Query: 15 GGLGGPLPGSS--PAR---GAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAAS 69
G L G L G S PAR G A RA GP G A GS Y A +
Sbjct: 11 GRLLGSLRGLSGQPARPPCGVSAPRRA--ASGPSGSAPAVAAAAAQPGS---YPALSAQA 65
Query: 70 VTDPERFWGKAA-EQISWYKPWTKTLENKHSPST-RWFVEGMLNICYNAVDRHIENGKGD 127
+P FWG A + + W P+ + S WF+ G LN+ N +D+H+ +
Sbjct: 66 AREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSP-E 124
Query: 128 KIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLA 187
+A+I++ T+ TY+E+LE +LA L +HG+ +GD V IYMP+ P A+ MLA
Sbjct: 125 SVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLA 184
Query: 188 CARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQH 247
CARIGA+H++IF GF+++ L+ RI+ K KVV+T + G+ GR VE +V+EA+K H
Sbjct: 185 CARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK---H 241
Query: 248 KP--DKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVP--VLSEHPLYILYTSGTT 303
P +L+ +R + + D+ ++EMAK + C P + SE L++LYTSG+T
Sbjct: 242 CPTVQHVLVAHRTDNKV--HMGDLDVPLEQEMAK-EDPVCAPESMGSEDMLFMLYTSGST 298
Query: 304 GLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTV 363
G+PKG++ GY + + ++ QPG+++ +D+GW+ GHSY+ YGPL +G T+V
Sbjct: 299 GMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSV 358
Query: 364 LYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFV 423
L+E PV P+AG Y+ + + + APTA+R + + G A K+Y + +TL
Sbjct: 359 LFESTPV-YPNAGRYWETVERLKINQFYGAPTAVRLLLKY--GDAWVKKYDRSSLRTLGS 415
Query: 424 AGERCDVETLEWSKNVF---RVPVLDHWWQTETGSPITASCVGLGNSKTPP---PGQAGK 477
GE + E EW V R ++D WWQTETG C+ S+ P A +
Sbjct: 416 VGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETG----GICIAPRPSEEGAEILPAMAMR 471
Query: 478 SVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDT 537
G +++D+ ++ + + PG ++ + + F YF+ +PGYY T
Sbjct: 472 PFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFT 531
Query: 538 MDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHV 597
D Y E GY + R+DDVIN++GHR+ IE++I H V + AV+G +KG
Sbjct: 532 GDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEA 591
Query: 598 PLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSA 657
A V+ KD + V++E+ V I A + VK+LPKTRSGK+ R L
Sbjct: 592 AFAFIVV-KDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRK 650
Query: 658 IVNGKPYKI--TSTIEDPSIFGHV 679
I+ + ++ T+T+EDPSI +
Sbjct: 651 IITSEAQELGDTTTLEDPSIIAEI 674
>gi|8923896 acyl-CoA synthetase short-chain family member 2 isoform
1 [Homo sapiens]
Length = 701
Score = 363 bits (931), Expect = e-100
Identities = 237/690 (34%), Positives = 346/690 (50%), Gaps = 61/690 (8%)
Query: 41 GPRG----GLGGRG---------CRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWY 87
G RG G GGR R+ S Y+ SV +P FWG A++ W
Sbjct: 13 GSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWK 72
Query: 88 KPWTKTLENKHSPSTR------WFVEGMLNICYNAVDRHIENGK-GDKIAIIYDSPVTNT 140
P + T+ W NICYN +DR++ K GDK+A ++
Sbjct: 73 TPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGE 132
Query: 141 KATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFG 200
TY ++L QV + + VL K GI+KGD V IYMPMIP+ + MLACARIGA+HS++F
Sbjct: 133 TTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFA 192
Query: 201 GFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHK--PDKILIYNR- 257
GF+S+ L RI +++T + V L +EAL+ Q K P + I +
Sbjct: 193 GFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKH 252
Query: 258 ----------------------PNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVL--SEHP 293
P+++ + G DL W E M +A +C P +E P
Sbjct: 253 LGRAELGMGDSTSQSPPIKRSCPDVQ-ISWNQGIDLWWHELMQEA-GDECEPEWCDAEDP 310
Query: 294 LYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICY 353
L+ILYTSG+TG PKGV+ GGY + + + ++ +V+W +D+GW+ GHSY+ Y
Sbjct: 311 LFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTY 370
Query: 354 GPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQY 413
GPL +G T+VL+EG P PD + ++ ++ V +TAPTAIR + + G ++
Sbjct: 371 GPLANGATSVLFEGIPT-YPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKF--GDEPVTKH 427
Query: 414 SLTRFKTLFVAGERCDVETLEWSKNVF---RVPVLDHWWQTETGSPITASCVGLGNSKTP 470
S + L GE + E W V R P++D +WQTETG + G K
Sbjct: 428 SRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMK-- 485
Query: 471 PPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEK 530
PG A G IL+++ ++L+ G +V K P PG ++ N E F+ YF+K
Sbjct: 486 -PGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPW-PGIMRTVYGNHERFETTYFKK 543
Query: 531 FPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKE 590
FPGYY T D D++GY ++ R+DD++NV+GH +S +E +++ H VA+ AVVG
Sbjct: 544 FPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHP 603
Query: 591 DPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKI 650
P+KG L V D + ++ EE+ K +R+ IGP+A LPKTRSGKI
Sbjct: 604 HPVKGEC-LYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKI 662
Query: 651 PRSALSAIV-NGKPYKITSTIEDPSIFGHV 679
R L I N ST+ DPS+ H+
Sbjct: 663 MRRVLRKIAQNDHDLGDMSTVADPSVISHL 692
>gi|253970489 acyl-CoA synthetase short-chain family member 2
isoform 2 [Homo sapiens]
Length = 714
Score = 360 bits (923), Expect = 3e-99
Identities = 237/702 (33%), Positives = 344/702 (49%), Gaps = 72/702 (10%)
Query: 41 GPRG----GLGGRG---------CRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWY 87
G RG G GGR R+ S Y+ SV +P FWG A++ W
Sbjct: 13 GSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWK 72
Query: 88 KPWTKTLENKHSPSTR------WFVEGMLNICYNAVDRHIENGK-GDKIAIIYDSPVTNT 140
P + T+ W NICYN +DR++ K GDK+A ++
Sbjct: 73 TPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGE 132
Query: 141 KATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFG 200
TY ++L QV + + VL K GI+KGD V IYMPMIP+ + MLACARIGA+HS++F
Sbjct: 133 TTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFA 192
Query: 201 GFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHK------------ 248
GF+S+ L RI +++T + V L +EAL+ Q K
Sbjct: 193 GFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKH 252
Query: 249 ----------------------PD---KILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSH 283
PD K+ ++ + G DL W E M +A
Sbjct: 253 LGRAELGMGDSTSQSPPIKRSCPDVQGKLKEKSKRVQPQISWNQGIDLWWHELMQEA-GD 311
Query: 284 DCVPVL--SEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASD 341
+C P +E PL+ILYTSG+TG PKGV+ GGY + + + ++ +V+W +D
Sbjct: 312 ECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTAD 371
Query: 342 LGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIR 401
+GW+ GHSY+ YGPL +G T+VL+EG P PD + ++ ++ V +TAPTAIR +
Sbjct: 372 IGWITGHSYVTYGPLANGATSVLFEGIPT-YPDVNRLWSIVDKYKVTKFYTAPTAIRLLM 430
Query: 402 QQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVF---RVPVLDHWWQTETGSPIT 458
+ G ++S + L GE + E W V R P++D +WQTETG +
Sbjct: 431 KF--GDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHML 488
Query: 459 ASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWK 518
G K PG A G IL+++ ++L+ G +V K P PG ++
Sbjct: 489 TPLPGATPMK---PGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPW-PGIMRTVYG 544
Query: 519 NQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSH 578
N E F+ YF+KFPGYY T D D++GY ++ R+DD++NV+GH +S +E +++ H
Sbjct: 545 NHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEH 604
Query: 579 GTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVF 638
VA+ AVVG P+KG L V D + ++ EE+ K +R+ IGP+A
Sbjct: 605 EAVAEAAVVGHPHPVKGEC-LYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQN 663
Query: 639 VKQLPKTRSGKIPRSALSAIV-NGKPYKITSTIEDPSIFGHV 679
LPKTRSGKI R L I N ST+ DPS+ H+
Sbjct: 664 APGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHL 705
>gi|115511026 acyl-CoA synthetase medium-chain family member 1 [Homo
sapiens]
Length = 577
Score = 167 bits (424), Expect = 2e-41
Identities = 142/541 (26%), Positives = 246/541 (45%), Gaps = 57/541 (10%)
Query: 123 NGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQA 181
NG+GD++ ++++E+ + ++A V + G+++GD + + +P +P+
Sbjct: 78 NGQGDEVK-------------WSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEW 124
Query: 182 MYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTA-SFGIEPGRRVEYVPLVEE 240
+ C R G I +K++ R+ K K +VT + E P ++
Sbjct: 125 WLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKT 184
Query: 241 ALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTS 300
L + H + L + A P H CV + P+ I +TS
Sbjct: 185 KLLVSDHSREGWLDFRSLVKSASP-----------------EHTCVKSKTLDPMVIFFTS 227
Query: 301 GTTGLPKGVIRPTGGYAVMLHWSMS-SIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHG 359
GTTG PK + + + G A+ + S + L+ +V W SD GW+V + P G
Sbjct: 228 GTTGFPK-MAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAG 286
Query: 360 NTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFK 419
T ++ + D + L ++ + + + R I QQD ++ RF
Sbjct: 287 CTVFIHH---LPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQD--------FTSIRFP 335
Query: 420 TL---FVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAG 476
L + GE + E K + + +++ Q+ETG I A+ G+ PG G
Sbjct: 336 ALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGL-ICATYWGMKIK----PGFMG 390
Query: 477 KSVPGYNVMILDDNMQKLKARCLGNIVVKL-PLPPGAFSGLWKNQEAFKHLYFEKFPGYY 535
K+ P Y+V ++DD L GNI +++ P+ P + ++ + + +Y
Sbjct: 391 KATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDP--EKTAKVECGDFY 448
Query: 536 DTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKG 595
+T D G MDEEGY+ + R DD+IN +G+RI +E +++ H VA+ AVVG DP++G
Sbjct: 449 NTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRG 508
Query: 596 HVPLALCVLRKD-INATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSA 654
V A VL ++ ++Q+ +E+ +HV+ P R FV +LPKT +GKI R
Sbjct: 509 EVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKE 568
Query: 655 L 655
L
Sbjct: 569 L 569
>gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Homo
sapiens]
Length = 579
Score = 166 bits (420), Expect = 7e-41
Identities = 144/529 (27%), Positives = 241/529 (45%), Gaps = 37/529 (6%)
Query: 138 TNTKATFTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHS 196
T + ++++E+ +Q K A VL G++ GD +++ +P +P+ +AC R G +
Sbjct: 84 TGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMI 143
Query: 197 LIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYN 256
K+L R+ + K ++T+ + P RV+ + +L+ K+L+ +
Sbjct: 144 PGVTQLTEKDLKYRLQASRAKSIITSD-SLAP--RVDAISAECPSLQT------KLLVSD 194
Query: 257 RPNMEAVPLAPGRDLDWDEEMAKAQS-HDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGG 315
PG L++ E + +A + H+C+ S PL I +TSGTTG PK V
Sbjct: 195 SSR-------PGW-LNFRELLREASTEHNCMRTKSRDPLAIYFTSGTTGAPKMVEHSQSS 246
Query: 316 YAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDA 375
Y + S L +++W +D GWV ++ + +G+ ++E V DA
Sbjct: 247 YGLGFVASGRRWVALTESDIFWNTTDTGWVKA-AWTLFSAWPNGSCIFVHELPRV---DA 302
Query: 376 GAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEW 435
L++ + L PT R + Q+D +Y + GE + + E
Sbjct: 303 KVILNTLSKFPITTLCCVPTIFRLLVQEDL-----TRYQFQSLRHCLTGGEALNPDVREK 357
Query: 436 SKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLK 495
K+ V + + + Q+ET C K G GK+ P Y+V I+DD L
Sbjct: 358 WKHQTGVELYEGYGQSET----VVICANPKGMKIKS-GSMGKASPPYDVQIVDDEGNVLP 412
Query: 496 ARCLGNIVVKL-PLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSR 554
GN+ V++ P P F + + + + +Y T D MD++GY + M R
Sbjct: 413 PGEEGNVAVRIRPTRPFCFFNCYLDNP--EKTAASEQGDFYITGDRARMDKDGYFWFMGR 470
Query: 555 VDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQ 614
DDVIN + +RI +E ++ H V + AVV DP++G V A VL ++ + +
Sbjct: 471 NDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDPE 530
Query: 615 VL-EEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGK 662
L E+ +HV++ P R FV +LPKT SGKI RS L + GK
Sbjct: 531 ALTRELQEHVKRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLRSQEWGK 579
>gi|42544132 SA hypertension-associated homolog isoform 1 [Homo
sapiens]
Length = 586
Score = 162 bits (409), Expect = 1e-39
Identities = 138/518 (26%), Positives = 226/518 (43%), Gaps = 40/518 (7%)
Query: 144 FTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGF 202
++++E+ K A +L + +++GD V++ +P +P+ +AC R G +
Sbjct: 95 WSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQL 154
Query: 203 ASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEA 262
K++ R+ K ++T P V+ ++ K+++
Sbjct: 155 TQKDILYRLQSSKANCIITNDV---------LAPAVDAVASKCENLHSKLIVSENSREGW 205
Query: 263 VPLAPGRDLDWDEEMAK--AQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVML 320
L +E+ K + SH CV + I +TSGT+G PK + + L
Sbjct: 206 GNL---------KELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGL 256
Query: 321 HWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFR 380
+ L P +V W SD GW + P + G V P P + +
Sbjct: 257 SVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQG-ACVFTHHLPRFEPTS--ILQ 313
Query: 381 VLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVF 440
L+++ + +APT R + Q D + Y K AGE + E +N
Sbjct: 314 TLSKYPITVFCSAPTVYRMLVQNDITS-----YKFKSLKHCVSAGEPITPDVTEKWRNKT 368
Query: 441 RVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLG 500
+ + + + QTET C K P G GK P ++V I+D N L G
Sbjct: 369 GLDIYEGYGQTET----VLICGNFKGMKIKP-GSMGKPSPAFDVKIVDVNGNVLPPGQEG 423
Query: 501 NIVVK-LPLPP-GAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDV 558
+I ++ LP P G F+ N F Y T D GYMD++GY + ++R DDV
Sbjct: 424 DIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNF---YITGDRGYMDKDGYFWFVARADDV 480
Query: 559 INVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINA-TEEQVLE 617
I +G+RI +E ++ H +VA+ AVV DP++G V A VL D + +EQ+++
Sbjct: 481 ILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIK 540
Query: 618 EIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
EI +HV++ P R F+++LPKT SGK R+ L
Sbjct: 541 EIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNEL 578
>gi|122937307 acyl-CoA synthetase medium-chain family member 4 [Homo
sapiens]
Length = 580
Score = 161 bits (407), Expect = 2e-39
Identities = 143/537 (26%), Positives = 229/537 (42%), Gaps = 49/537 (9%)
Query: 123 NGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQA 181
NGKGD++ ++++E+ K A VL K G+++GD + + +P IP+
Sbjct: 81 NGKGDEVK-------------WSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEW 127
Query: 182 MYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEA 241
+AC R G I +K++ R+ K K +V + E P VE
Sbjct: 128 WLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASE---------EVAPAVESI 178
Query: 242 LKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKA-QSHDCVPVLSEHPLYILYTS 300
+ K+L+ P + L + E A + H CV S+ P+ I +TS
Sbjct: 179 VLECPDLKTKLLVS--------PQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTS 230
Query: 301 GTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGN 360
GTTG PK + L+ ++ W SD GWV + L G
Sbjct: 231 GTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGA 290
Query: 361 TTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKT 420
++ + D + L + + L + PT R + Q+D K+Y +
Sbjct: 291 CVFVHR---MAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDL-----KRYKFKSLRH 342
Query: 421 LFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVP 480
GE + E LE + + + + + QTE G I A+ G + PG GK +
Sbjct: 343 CLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGM-ICANQKG----QEIKPGSMGKGML 397
Query: 481 GYNVMILDDNMQKLKARCLGNIVVKL-PLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMD 539
Y+V I+D+N L G I ++L P P F + + +Y T D
Sbjct: 398 PYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRG--DFYVTGD 455
Query: 540 AGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPL 599
G MD +GY + + R DDVI +G+RI +E +++ H V + AVV D ++G V
Sbjct: 456 RGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVK 515
Query: 600 ALCVLRKDINA-TEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
A VL + E++ E+ HV+++ P R FV++LPKT +GKI R+ L
Sbjct: 516 AFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVL 572
>gi|58082049 acyl-CoA synthetase medium-chain family member 2A [Homo
sapiens]
Length = 577
Score = 159 bits (403), Expect = 6e-39
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 39/517 (7%)
Query: 144 FTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGF 202
+ ++E+ E + A VL G+++GD V + +P +P+ +L C R G I
Sbjct: 81 WNFRELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQM 140
Query: 203 ASKELSSRIDHVKPKVVVTASFGIEPGRRV-EYVPLVEEALKIGQHKPDKILIYNRPNME 261
S ++ R+ K K +V I+ V P + L + + D L + + E
Sbjct: 141 KSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNE 200
Query: 262 AVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLH 321
A + +H CV S+ I +TSGT+GLPK +
Sbjct: 201 A-----------------STTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAK 243
Query: 322 WSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRV 381
+ GLQ ++ W SD GW++ P G T ++ + D +
Sbjct: 244 MD-AGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHL---LPKFDPLVILKT 299
Query: 382 LAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFR 441
L+ + + ++ AP R + QQD + Y + GE ETLE +
Sbjct: 300 LSSYPIKSMMGAPIVYRMLLQQDLSS-----YKFPHLQNCVTVGESLLPETLENWRAQTG 354
Query: 442 VPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGN 501
+ + + + QTETG +C+ + + PG G + Y+V I+DD L G+
Sbjct: 355 LDIRESYGQTETG----LTCM-VSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGD 409
Query: 502 IVVKL-PLPP-GAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVI 559
I +++ P+ P G FSG N + F + D G DE+GY M R DD+I
Sbjct: 410 IGIRVKPIRPIGIFSGYVDNPDKTAANIRGDF---WLLGDRGIKDEDGYFQFMGRADDII 466
Query: 560 NVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKD-INATEEQVLEE 618
N +G+RI +E +++ H V + AV+ DP++G V A VL ++ EQ+ +E
Sbjct: 467 NSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKE 526
Query: 619 IVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
+ +HV+ P R FV LPKT +GKI R+ L
Sbjct: 527 LQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKL 563
>gi|157311624 acyl-CoA synthetase medium-chain family member 2B
[Homo sapiens]
Length = 577
Score = 157 bits (396), Expect = 4e-38
Identities = 137/521 (26%), Positives = 227/521 (43%), Gaps = 47/521 (9%)
Query: 144 FTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGF 202
+ ++E+ E + A +L G+++GD V + +P +P+ +L C R G I
Sbjct: 81 WNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQM 140
Query: 203 ASKELSSRIDHVKPKVVVTASFGIEPGRRV-EYVPLVEEALKIGQHKPDKILIYNRPNME 261
S ++ R+ K K +V I+ V P + L + + D L + + E
Sbjct: 141 KSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNE 200
Query: 262 AVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLH 321
A + +H CV S+ I +TSGT+GLPK +
Sbjct: 201 A-----------------STTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAK 243
Query: 322 WSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLH----GNTTVLYEGKPVGTPDAGA 377
+ GLQ ++ W SD GW++ G LL G T ++ + D
Sbjct: 244 MD-AGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHL---LPKFDPLV 295
Query: 378 YFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSK 437
+ L+ + + ++ AP R + QQD + Y + GE ETLE +
Sbjct: 296 ILKTLSSYPIKSMMGAPIVYRMLLQQDLSS-----YKFPHLQNCLAGGESLLPETLENWR 350
Query: 438 NVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKAR 497
+ + + + QTETG +C+ + + PG G + Y+V ++DD L
Sbjct: 351 AQTGLDIREFYGQTETG----LTCM-VSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPG 405
Query: 498 CLGNIVVKL-PLPP-GAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRV 555
G+I +++ P+ P G FSG +N + F + D G DE+GY M R
Sbjct: 406 TEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDF---WLLGDRGIKDEDGYFQFMGRA 462
Query: 556 DDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKD-INATEEQ 614
DD+IN +G+RI +E +++ H V + AV+ DP++G V A +L ++ EQ
Sbjct: 463 DDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQ 522
Query: 615 VLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
+ +E+ +HV+ P R FV LPKT +GKI R+ L
Sbjct: 523 LTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKL 563
>gi|157311622 acyl-CoA synthetase medium-chain family member 2B
[Homo sapiens]
Length = 577
Score = 157 bits (396), Expect = 4e-38
Identities = 137/521 (26%), Positives = 227/521 (43%), Gaps = 47/521 (9%)
Query: 144 FTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGF 202
+ ++E+ E + A +L G+++GD V + +P +P+ +L C R G I
Sbjct: 81 WNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQM 140
Query: 203 ASKELSSRIDHVKPKVVVTASFGIEPGRRV-EYVPLVEEALKIGQHKPDKILIYNRPNME 261
S ++ R+ K K +V I+ V P + L + + D L + + E
Sbjct: 141 KSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNE 200
Query: 262 AVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLH 321
A + +H CV S+ I +TSGT+GLPK +
Sbjct: 201 A-----------------STTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAK 243
Query: 322 WSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLH----GNTTVLYEGKPVGTPDAGA 377
+ GLQ ++ W SD GW++ G LL G T ++ + D
Sbjct: 244 MD-AGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHL---LPKFDPLV 295
Query: 378 YFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSK 437
+ L+ + + ++ AP R + QQD + Y + GE ETLE +
Sbjct: 296 ILKTLSSYPIKSMMGAPIVYRMLLQQDLSS-----YKFPHLQNCLAGGESLLPETLENWR 350
Query: 438 NVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKAR 497
+ + + + QTETG +C+ + + PG G + Y+V ++DD L
Sbjct: 351 AQTGLDIREFYGQTETG----LTCM-VSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPG 405
Query: 498 CLGNIVVKL-PLPP-GAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRV 555
G+I +++ P+ P G FSG +N + F + D G DE+GY M R
Sbjct: 406 TEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDF---WLLGDRGIKDEDGYFQFMGRA 462
Query: 556 DDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKD-INATEEQ 614
DD+IN +G+RI +E +++ H V + AV+ DP++G V A +L ++ EQ
Sbjct: 463 DDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQ 522
Query: 615 VLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
+ +E+ +HV+ P R FV LPKT +GKI R+ L
Sbjct: 523 LTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKL 563
>gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase
ACSM2B, mitochondrial isoform 2 [Homo sapiens]
Length = 571
Score = 139 bits (351), Expect = 7e-33
Identities = 133/519 (25%), Positives = 220/519 (42%), Gaps = 49/519 (9%)
Query: 144 FTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGF 202
+ ++E+ E + A VL G+++GD V + +P +P+ +L C R G I
Sbjct: 81 WNFRELSENSQQAANVLSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQM 140
Query: 203 ASKELSSRIDHVKPKVVVTASFGIEPGRRV-EYVPLVEEALKIGQHKPDKILIYNRPNME 261
S ++ R+ K K +V I+ V P + L + + D L + + E
Sbjct: 141 KSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNE 200
Query: 262 AVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLH 321
A + +H CV S+ I +TSGT+GLPK +
Sbjct: 201 A-----------------STTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAK 243
Query: 322 WSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLH----GNTTVLYEGKPVGTPDAGA 377
+ GLQ ++ W SD GW++ G LL G T ++ + D
Sbjct: 244 MD-AGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHL---LPKFDPLV 295
Query: 378 YFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSK 437
+ L+ + + ++ AP R + QQD + Y + GE ETLE +
Sbjct: 296 ILKTLSSYPIKSMMGAPIVYRMLLQQDLSS-----YKFPHLQNCLAGGESLLPETLENWR 350
Query: 438 NVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKAR 497
+ + + + QTETG +C+ + + PG G + Y+V ++ +A
Sbjct: 351 AQTGLDIREFYGQTETG----LTCM-VSKTMKIKPGYMGTAASCYDVQVIAFVHGSPRAG 405
Query: 498 CLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDD 557
LG + L +F G +N + F + D G DE+GY M R DD
Sbjct: 406 DLG-FAGTMTL---SFCGHQENPDKTAANIRGDF---WLLGDRGIKDEDGYFQFMGRADD 458
Query: 558 VINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKD-INATEEQVL 616
+IN +G+RI +E +++ H V + AV+ DP++G V A +L ++ EQ+
Sbjct: 459 IINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLT 518
Query: 617 EEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
+E+ +HV+ P R FV LPKT +GKI R+ L
Sbjct: 519 KELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKL 557
>gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase
ACSM2B, mitochondrial isoform 1 [Homo sapiens]
Length = 571
Score = 139 bits (351), Expect = 7e-33
Identities = 133/519 (25%), Positives = 220/519 (42%), Gaps = 49/519 (9%)
Query: 144 FTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGF 202
+ ++E+ E + A VL G+++GD V + +P +P+ +L C R G I
Sbjct: 81 WNFRELSENSQQAANVLSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQM 140
Query: 203 ASKELSSRIDHVKPKVVVTASFGIEPGRRV-EYVPLVEEALKIGQHKPDKILIYNRPNME 261
S ++ R+ K K +V I+ V P + L + + D L + + E
Sbjct: 141 KSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNE 200
Query: 262 AVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLH 321
A + +H CV S+ I +TSGT+GLPK +
Sbjct: 201 A-----------------STTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAK 243
Query: 322 WSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLH----GNTTVLYEGKPVGTPDAGA 377
+ GLQ ++ W SD GW++ G LL G T ++ + D
Sbjct: 244 MD-AGWTGLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHL---LPKFDPLV 295
Query: 378 YFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSK 437
+ L+ + + ++ AP R + QQD + Y + GE ETLE +
Sbjct: 296 ILKTLSSYPIKSMMGAPIVYRMLLQQDLSS-----YKFPHLQNCLAGGESLLPETLENWR 350
Query: 438 NVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKAR 497
+ + + + QTETG +C+ + + PG G + Y+V ++ +A
Sbjct: 351 AQTGLDIREFYGQTETG----LTCM-VSKTMKIKPGYMGTAASCYDVQVIAFVHGSPRAG 405
Query: 498 CLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDD 557
LG + L +F G +N + F + D G DE+GY M R DD
Sbjct: 406 DLG-FAGTMTL---SFCGHQENPDKTAANIRGDF---WLLGDRGIKDEDGYFQFMGRADD 458
Query: 558 VINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKD-INATEEQVL 616
+IN +G+RI +E +++ H V + AV+ DP++G V A +L ++ EQ+
Sbjct: 459 IINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLT 518
Query: 617 EEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
+E+ +HV+ P R FV LPKT +GKI R+ L
Sbjct: 519 KELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKL 557
>gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens]
Length = 672
Score = 119 bits (299), Expect = 7e-27
Identities = 135/594 (22%), Positives = 249/594 (41%), Gaps = 53/594 (8%)
Query: 104 WFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKH 163
WF LN N + RH EN D++A+ T++E+ ++V+ A + K
Sbjct: 93 WFKGSRLNYAENLL-RHKEN---DRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKM 148
Query: 164 GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTAS 223
G+KKGD VV Y+P A+ MLA A IGAI S F + R ++PK++ +
Sbjct: 149 GVKKGDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVE 208
Query: 224 FGIEPGRRVEYVPLVEEALKIGQHKPDKILIY----NRPNMEAVPLAPGRDLD-----WD 274
+ G+ ++ +++ +K G K+++ +R N++ + LD
Sbjct: 209 AVVYNGKEHNHMEKLQQVVK-GLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGT 267
Query: 275 EEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAV------MLHWSMSSIY 328
E A + +P HPL+I+++SGTTG PK ++ GG + +LH +M+S
Sbjct: 268 SEQAPQLEFEQLPF--SHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTS-- 323
Query: 329 GLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVA 388
++ + +GW++ + + L G VLY+G P+ P + ++ G+
Sbjct: 324 ----SDILLCYTTVGWMMWNWMVSL--LATGAAMVLYDGSPL-VPTPNVLWDLVDRIGIT 376
Query: 389 ALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHW 448
L T + + ++ + +SL T+ G ++ E+ + +L
Sbjct: 377 VLVTGAKWLSVLEEKAMKPV--ETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSIL--L 432
Query: 449 WQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPL 508
G+ I + +G S G+ G V ++ + + G +V P+
Sbjct: 433 GSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGES-GELVCTKPI 491
Query: 509 P--PGAFSGLW--KNQEAFKHLYFEKFPGYYDTMDAGYMD-EEGYLYVMSRVDDVINVAG 563
P P F W +N ++ YF KFPG + D ++ + G + ++ R D +N G
Sbjct: 492 PCQPTHF---WNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNG 548
Query: 564 HRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHV 623
R + I + S V D V + + + + + A+ ++VK +
Sbjct: 549 VRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKM-----ASGHAFQPDLVKRI 603
Query: 624 RQNIGPVAAFRNA----VFVKQLPKTRSGKIPRSALSAIVNGKPYKITSTIEDP 673
R I + R+ + K +P T +GK A+ I+ GK + +P
Sbjct: 604 RDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNP 657
>gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Homo
sapiens]
Length = 480
Score = 91.3 bits (225), Expect = 3e-18
Identities = 107/427 (25%), Positives = 176/427 (41%), Gaps = 43/427 (10%)
Query: 148 EVLEQVSKLAGVLVKH--GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASK 205
E + Q+SK A ++ + GD ++I +P P+A + LAC R+G +K
Sbjct: 89 ERMTQLSKKAASILSDTCALSHGDRLMIILPPTPEAYWICLACVRLGITFVPGSPQLTAK 148
Query: 206 ELSSRIDHVKPKVVVTASFGIEP--GRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEAV 263
++ ++ K + +V A+ + P V P ++ L + D L + + +
Sbjct: 149 KIRYQLRMSKAQCIV-ANEAMAPVVNSAVSDCPTLKTKLLVSDKSYDGWLDFKK----LI 203
Query: 264 PLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWS 323
+AP + + + +S D P+ I +T GTTG PK V G + +
Sbjct: 204 QVAPPK-----QTYMRTKSQD--------PMAIFFTKGTTGAPKMVEYSQYGLGMGFSQA 250
Query: 324 MSSIYGLQPGEVWWAASD-LGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVL 382
LQP +V W+ D G + S + G G L P P+ VL
Sbjct: 251 SRRWMDLQPTDVLWSLGDAFGGSLSLSAVL-GTWFQGACVFLCH-MPTFCPET--VLNVL 306
Query: 383 AEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTL---FVAGERCDVETLEWSKNV 439
+ + L P + + Q K ++ RFK+L AG +E K +
Sbjct: 307 SRFPITTLSANPEMYQELLQH-------KCFTSYRFKSLKQCVAAGGPISPGVIEDWKRI 359
Query: 440 FRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCL 499
++ + + + QTETG S + P GK +P Y V I+D+N L
Sbjct: 360 TKLDIYEGYGQTETGLLCATS-----KTIKLKPSSLGKPLPPYIVQIVDENSNLLPPGEE 414
Query: 500 GNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVI 559
GNI +++ L A S + +++ + Y T D G MDE+GY + RVDDV
Sbjct: 415 GNIAIRIKLNQPA-SLYCPHMVSWEEYASARGHMLYLTGDRGIMDEDGYFWWSGRVDDVA 473
Query: 560 NVAGHRI 566
N G R+
Sbjct: 474 NALGQRL 480
>gi|42544134 SA hypertension-associated homolog isoform 2 [Homo
sapiens]
Length = 438
Score = 74.7 bits (182), Expect = 3e-13
Identities = 82/373 (21%), Positives = 141/373 (37%), Gaps = 41/373 (10%)
Query: 144 FTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGF 202
++++E+ K A +L + +++GD V++ +P +P+ +AC R G +
Sbjct: 95 WSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQL 154
Query: 203 ASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEA 262
K++ R+ K ++T P V+ ++ K+++
Sbjct: 155 TQKDILYRLQSSKANCIITNDV---------LAPAVDAVASKCENLHSKLIVSENSREGW 205
Query: 263 VPLAPGRDLDWDEEMAK--AQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVML 320
L +E+ K + SH CV + I +TSGT+G PK + + L
Sbjct: 206 GNL---------KELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGL 256
Query: 321 HWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFR 380
+ L P +V W SD GW + P + G V P P + +
Sbjct: 257 SVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQG-ACVFTHHLPRFEPT--SILQ 313
Query: 381 VLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVF 440
L+++ + +APT R + Q D Y K AGE + E +N
Sbjct: 314 TLSKYPITVFCSAPTVYRMLVQNDI-----TSYKFKSLKHCVSAGEPITPDVTEKWRNKT 368
Query: 441 RVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLG 500
+ + + + QTET C K PG GK P ++V + + R
Sbjct: 369 GLDIYEGYGQTET----VLICGNFKGMKI-KPGSMGKPSPAFDVKVCTSPSR----RMFN 419
Query: 501 NIVVKLP---LPP 510
N + LP LPP
Sbjct: 420 NPICTLPTYRLPP 432
>gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]
Length = 576
Score = 69.7 bits (169), Expect = 8e-12
Identities = 94/407 (23%), Positives = 160/407 (39%), Gaps = 83/407 (20%)
Query: 296 ILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYG- 354
I+YTSGTTG PKGV+ H ++ ++ + W D+ V + +G
Sbjct: 199 IIYTSGTTGRPKGVLST--------HQNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGV 250
Query: 355 ------PLLHGNTTVLY-EGKPVG---------TPDAGAYFRV------LAEHGVAALFT 392
PL G T V+ E P TP + V L E+ FT
Sbjct: 251 VNALLCPLWVGATCVMMPEFSPQQVWEKFLSSETPRINVFMAVPTIYTKLMEY-YDRHFT 309
Query: 393 APTA---IRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWW 449
P A +RA+ ++ + + + + LE KN+ +L+ +
Sbjct: 310 QPHAQDFLRAVCEE-------------KIRLMVSGSAALPLPVLEKWKNITGHTLLERYG 356
Query: 450 QTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCL---------- 499
TE G ++ G + PG G +PG V I+ +N Q+
Sbjct: 357 MTEIGMALS----GPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGT 412
Query: 500 ----------GNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYL 549
G ++V+ P F W E K + G++ T D + ++G
Sbjct: 413 KVTPGFEEKEGELLVR---GPSVFREYWNKPEETKSAF--TLDGWFKTGDT-VVFKDGQY 466
Query: 550 YVMSRVD-DVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDI 608
++ R D+I G+++SA +E +L+H ++ D AV+G D G A+ LR+
Sbjct: 467 WIRGRTSVDIIKTGGYKVSALEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGH 526
Query: 609 NATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
+ + E+ + R + P A V V+++P+ + GKI + AL
Sbjct: 527 SLSH----RELKEWARNVLAPYAVPSELVLVEEIPRNQMGKIDKKAL 569
>gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]
Length = 576
Score = 69.7 bits (169), Expect = 8e-12
Identities = 94/407 (23%), Positives = 160/407 (39%), Gaps = 83/407 (20%)
Query: 296 ILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYG- 354
I+YTSGTTG PKGV+ H ++ ++ + W D+ V + +G
Sbjct: 199 IIYTSGTTGRPKGVLST--------HQNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGV 250
Query: 355 ------PLLHGNTTVLY-EGKPVG---------TPDAGAYFRV------LAEHGVAALFT 392
PL G T V+ E P TP + V L E+ FT
Sbjct: 251 VNALLCPLWVGATCVMMPEFSPQQVWEKFLSSETPRINVFMAVPTIYTKLMEY-YDRHFT 309
Query: 393 APTA---IRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWW 449
P A +RA+ ++ + + + + LE KN+ +L+ +
Sbjct: 310 QPHAQDFLRAVCEE-------------KIRLMVSGSAALPLPVLEKWKNITGHTLLERYG 356
Query: 450 QTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCL---------- 499
TE G ++ G + PG G +PG V I+ +N Q+
Sbjct: 357 MTEIGMALS----GPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGT 412
Query: 500 ----------GNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYL 549
G ++V+ P F W E K + G++ T D + ++G
Sbjct: 413 KVTPGFEEKEGELLVR---GPSVFREYWNKPEETKSAF--TLDGWFKTGDT-VVFKDGQY 466
Query: 550 YVMSRVD-DVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDI 608
++ R D+I G+++SA +E +L+H ++ D AV+G D G A+ LR+
Sbjct: 467 WIRGRTSVDIIKTGGYKVSALEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGH 526
Query: 609 NATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSAL 655
+ + E+ + R + P A V V+++P+ + GKI + AL
Sbjct: 527 SLSH----RELKEWARNVLAPYAVPSELVLVEEIPRNQMGKIDKKAL 569
>gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]
Length = 615
Score = 68.6 bits (166), Expect = 2e-11
Identities = 129/553 (23%), Positives = 214/553 (38%), Gaps = 74/553 (13%)
Query: 137 VTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHS 196
V + T+ ++ E+V K A L+ G+ KGD + ++ P + LA A+ G I
Sbjct: 93 VLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 152
Query: 197 LIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYN 256
+ + + EL + V K +V F + + Y L + ++ +P +
Sbjct: 153 SVNPAYQAMELEYVLKKVGCKALV---FPKQFKTQQYYNVLKQICPEVENAQPGALKSQR 209
Query: 257 RPNMEAV-----PLAPGRDLDWDEEMAKAQSHDCVPVLSEH--------PLYILYTSGTT 303
P++ V PL PG L DE +A + + L + P+ I +TSGTT
Sbjct: 210 LPDLTTVISVDAPL-PGTLL-LDEVVAAGSTRQHLDQLQYNQQFLSCHDPINIQFTSGTT 267
Query: 304 GLPKGVIRPTGGYAVMLHWSM---SSIYGLQPGEVWWAASDLGWVVGHS-YICYGP---- 355
G PKG A + H+++ S+I G + L ++ + Y C G
Sbjct: 268 GSPKG--------ATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGT 319
Query: 356 ---LLHGNTTVL----YEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAA 408
L++G T +L + GK A + E G T + + Q D +
Sbjct: 320 MMCLMYGATLILASPIFNGKK-------ALEAISRERGTFLYGTPTMFVDILNQPDFSS- 371
Query: 409 LGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSK 468
Y ++ +AG E + N + L + T SP+T + ++
Sbjct: 372 ----YDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFP-EDTV 426
Query: 469 TPPPGQAGKSVPGYNVMILD---DNMQKLKAR---CLGNIVVKLPLPPGAFSGLWKNQEA 522
G+ +P I++ + KL C+ V L G + K +EA
Sbjct: 427 EQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVML----GYWGEPQKTEEA 482
Query: 523 FKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVA 582
+Y T D M+E+G+ ++ R D+I G I +E+ +H V
Sbjct: 483 VDQ------DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQ 536
Query: 583 DCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQL 642
+ VVG +D G + C+ KD EE +EEI + I + VFV
Sbjct: 537 EVQVVGVKDDRMGE-EICACIRLKD---GEETTVEEIKAFCKGKISHFKIPKYIVFVTNY 592
Query: 643 PKTRSGKIPRSAL 655
P T SGKI + L
Sbjct: 593 PLTISGKIQKFKL 605
>gi|62865631 solute carrier family 27 (fatty acid transporter),
member 6 [Homo sapiens]
Length = 619
Score = 57.8 bits (138), Expect = 3e-08
Identities = 52/200 (26%), Positives = 93/200 (46%), Gaps = 27/200 (13%)
Query: 117 VDRHIENGKGD--KIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHG-IKKGDTVVI 173
+D+ + + K K IIY+ + +TY++V ++ S++A V + H +KKGDTV +
Sbjct: 57 LDKFLSHAKRQPRKPFIIYEGDI------YTYQDVDKRSSRVAHVFLNHSSLKKGDTVAL 110
Query: 174 YMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVE 233
M P ++ A++G + + + S L + I P+ +V + + G E
Sbjct: 111 LMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLL--GTVEE 168
Query: 234 YVPLVEEALKIGQHKPDKILIYNRPNMEAVP---LAPGRDLDWDEEMAKAQSHDCVPVLS 290
+P + E + + K ++VP ++ L + +SH V +L
Sbjct: 169 ILPSLSENISVWGMK------------DSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLK 216
Query: 291 EHPLYILYTSGTTGLPKGVI 310
LYI +TSGTTGLPK +
Sbjct: 217 STCLYI-FTSGTTGLPKAAV 235
Score = 33.1 bits (74), Expect = 0.88
Identities = 23/98 (23%), Positives = 42/98 (42%), Gaps = 9/98 (9%)
Query: 528 FEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESI-----LSHGTVA 582
F+K Y +T D D++ +LY R D G ++ + + I + V
Sbjct: 453 FKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVY 512
Query: 583 DCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIV 620
A+ G E G +A +L+ + + E+V E++V
Sbjct: 513 GVAISGYE----GRAGMASIILKPNTSLDLEKVYEQVV 546
>gi|13325055 solute carrier family 27 (fatty acid transporter),
member 6 [Homo sapiens]
Length = 619
Score = 57.8 bits (138), Expect = 3e-08
Identities = 52/200 (26%), Positives = 93/200 (46%), Gaps = 27/200 (13%)
Query: 117 VDRHIENGKGD--KIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHG-IKKGDTVVI 173
+D+ + + K K IIY+ + +TY++V ++ S++A V + H +KKGDTV +
Sbjct: 57 LDKFLSHAKRQPRKPFIIYEGDI------YTYQDVDKRSSRVAHVFLNHSSLKKGDTVAL 110
Query: 174 YMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVE 233
M P ++ A++G + + + S L + I P+ +V + + G E
Sbjct: 111 LMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLL--GTVEE 168
Query: 234 YVPLVEEALKIGQHKPDKILIYNRPNMEAVP---LAPGRDLDWDEEMAKAQSHDCVPVLS 290
+P + E + + K ++VP ++ L + +SH V +L
Sbjct: 169 ILPSLSENISVWGMK------------DSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLK 216
Query: 291 EHPLYILYTSGTTGLPKGVI 310
LYI +TSGTTGLPK +
Sbjct: 217 STCLYI-FTSGTTGLPKAAV 235
Score = 33.1 bits (74), Expect = 0.88
Identities = 23/98 (23%), Positives = 42/98 (42%), Gaps = 9/98 (9%)
Query: 528 FEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESI-----LSHGTVA 582
F+K Y +T D D++ +LY R D G ++ + + I + V
Sbjct: 453 FKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVY 512
Query: 583 DCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIV 620
A+ G E G +A +L+ + + E+V E++V
Sbjct: 513 GVAISGYE----GRAGMASIILKPNTSLDLEKVYEQVV 546
>gi|40807357 solute carrier family 27 (fatty acid transporter),
member 4 [Homo sapiens]
Length = 643
Score = 56.2 bits (134), Expect = 1e-07
Identities = 110/499 (22%), Positives = 188/499 (37%), Gaps = 78/499 (15%)
Query: 127 DKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTML 186
DK A+I++ T+ +T++++ E S +A L G+ GD I+M + + L
Sbjct: 89 DKTALIFEGTDTH----WTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWL 144
Query: 187 ACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQ 246
A++G +LI L + + + +V FG E + ++
Sbjct: 145 GMAKLGVEAALINTNLRRDALLHCLTTSRARALV---FGSE---------MASAICEVHA 192
Query: 247 HKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSH--DCVPVLSEHPLYILYTSGTTG 304
+ ++ + E + P + D + A H C L+ +YTSGTTG
Sbjct: 193 SLDPSLSLFCSGSWEPGAVPPSTE-HLDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTG 251
Query: 305 LPKGVIRPTGGY---AVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNT 361
LPK I Y A ++++ + ++P ++ + L G+ LLHG T
Sbjct: 252 LPKAAIVVHSRYYRMAALVYYG----FRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMT 307
Query: 362 TVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTL 421
V+ + A ++ ++ + R + Q P A + + +
Sbjct: 308 VVIRKKF-----SASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQH----QVRMA 358
Query: 422 FVAGERCDVETLEWSKNVFRVP-VLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVP 480
G R + T S+ F +P V + + TE +C LGN + Q G
Sbjct: 359 LGNGLRQSIWTNFSSR--FHIPQVAEFYGATE------CNC-SLGNFDS----QVGAC-- 403
Query: 481 GYNVMIL------------DDNMQKLKA--------------RCLGNIVVKLPLPP-GAF 513
G+N IL +D M+ ++ + +G I+ K PL +
Sbjct: 404 GFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGY 463
Query: 514 SGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEE 573
N + F+K Y T D MDE GYLY R D G +S +E
Sbjct: 464 LNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEG 523
Query: 574 SILSHGTVADCAVVGKEDP 592
++ +AD AV G E P
Sbjct: 524 TLSRLLDMADVAVYGVEVP 542
>gi|27477105 lipidosin [Homo sapiens]
Length = 724
Score = 42.4 bits (98), Expect = 0.001
Identities = 35/169 (20%), Positives = 75/169 (44%), Gaps = 13/169 (7%)
Query: 475 AGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGY 534
+GK VPG V +++ + + + CL + F G ++ E+ G+
Sbjct: 496 SGKLVPGCRVKLVNQDAEGIGEICLWGRTI--------FMGYLNMEDKTCEAIDEE--GW 545
Query: 535 YDTMDAGYMDEEGYLYVMSRVDD-VINVAGHRISAGAIEESI-LSHGTVADCAVVGKEDP 592
T DAG +D +G+LY+ R+ + +I G + IEE++ + +++ ++G +
Sbjct: 546 LHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRK 605
Query: 593 LKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQ 641
+ C L D + + + E+ ++ Q +G A + + K+
Sbjct: 606 FLSMLLTLKCTLDPDTSDQTDNLTEQAMEFC-QRVGSRATTVSEIIEKK 653
>gi|227499619 solute carrier family 27 (fatty acid transporter),
member 2 isoform 1 [Homo sapiens]
Length = 620
Score = 38.9 bits (89), Expect = 0.016
Identities = 48/174 (27%), Positives = 74/174 (42%), Gaps = 21/174 (12%)
Query: 143 TFTYKEVLEQVSKLAGVLVKH-GIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGG 201
T TY +V + +++A L H G+++GD V + M P ++ L ++G + +
Sbjct: 78 TLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNYN 137
Query: 202 FASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNME 261
+K L KV++ + E VEE L K D + IY +
Sbjct: 138 IRAKSLLHCFQCCGAKVLLVSP---------ELQAAVEEILP--SLKKDDVSIYY---VS 183
Query: 262 AVPLAPGRD--LDWDEEMAKA---QSHDCVPVLSEHPLYILYTSGTTGLPKGVI 310
G D LD +E++ +S S LYI YTSGTTGLPK +
Sbjct: 184 RTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYI-YTSGTTGLPKAAM 236
>gi|38524616 solute carrier family 27, member 1 [Homo sapiens]
Length = 646
Score = 35.8 bits (81), Expect = 0.14
Identities = 49/228 (21%), Positives = 93/228 (40%), Gaps = 17/228 (7%)
Query: 140 TKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIF 199
T +T+ ++ + +A + + G GD V I++ P+ + L A+ G +L+
Sbjct: 100 TGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLN 159
Query: 200 GGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPN 259
+ L+ + K ++ FG E +V ++ H ++ + +
Sbjct: 160 VNLRREPLAFCLGTSGAKALI---FGGE---------MVAAVAEVSGHLGKSLIKFCSGD 207
Query: 260 MEAVPLAPGRDLDWDEEMAKAQSHDCVPVLS---EHPLYILYTSGTTGLPKGVIRPTGGY 316
+ + P L D + +A + + S + L+ +YTSGTTGLPK I Y
Sbjct: 208 LGPEGILPDTHL-LDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRY 266
Query: 317 AVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVL 364
M + + Y +Q +V + L G+ L++G T VL
Sbjct: 267 YRMAAFGHHA-YRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVL 313
Score = 31.6 bits (70), Expect = 2.6
Identities = 21/68 (30%), Positives = 26/68 (38%)
Query: 525 HLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADC 584
H F K Y + D MDE GY+Y R D G +S +E + D
Sbjct: 478 HSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDV 537
Query: 585 AVVGKEDP 592
AV G P
Sbjct: 538 AVYGVAVP 545
>gi|148536864 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin d2 isoform 1 [Homo sapiens]
Length = 531
Score = 35.8 bits (81), Expect = 0.14
Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 7/54 (12%)
Query: 14 AGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRAL----SSGSGSEYK 63
A LG P P + P G ALR PGP GG+GG G A +G ++Y+
Sbjct: 22 AAALGAPPPPAGPGMLPGPALRG---PGPAGGVGGPGAAAFRPMGPAGPAAQYQ 72
>gi|45580730 aminoadipate-semialdehyde dehydrogenase [Homo sapiens]
Length = 1098
Score = 35.0 bits (79), Expect = 0.23
Identities = 87/390 (22%), Positives = 151/390 (38%), Gaps = 42/390 (10%)
Query: 279 KAQSHDCVPVLSEHPL-YILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWW 337
KA+ H + + +H L Y+L+TSGTTG+PK ++R V ++ + +V +
Sbjct: 179 KAEEH--MDLRLKHCLAYVLHTSGTTGIPK-IVRVPHKCIVPNIQHFRVLFDITQEDVLF 235
Query: 338 AASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAI 397
AS L + S + L ++L V + + + H V L PT +
Sbjct: 236 LASPLTF--DPSVVEIFLALSSGASLLIVPTSVKLLPSKLASVLFSHHRVTVLQATPTLL 293
Query: 398 RAIRQQDPGAALGKQYSL---TRFKTLFVAGERCDVETL--EWSKNVFRVPVLDHWWQTE 452
R G+ L K L T + L + GE T+ W + + + + TE
Sbjct: 294 RRF-----GSQLIKSTVLSATTSLRVLALGGEAFPSLTVLRSWRGEGNKTQIFNVYGITE 348
Query: 453 TGSPITASCVGL----GNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPL 508
S T + K P Q G + G V + D N ++ G + +
Sbjct: 349 VSSWATIYRIPEKTLNSTLKCELPVQLGFPLLGTVVEVRDTNGFTIQEGS-GQVFLG--- 404
Query: 509 PPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISA 568
G + + E L + G + T+ ++G ++ + R D I G R++
Sbjct: 405 --GRNRVCFLDDEVTVPLGTMRATGDFVTV------KDGEIFFLGRKDSQIKRHGKRLNI 456
Query: 569 GAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIG 628
+++ V CAV L L ++ KD + +E + +E+ K++ +
Sbjct: 457 ELVQQVAEELQQVESCAVTWYNQE-----KLILFMVSKDASV-KEYIFKELQKYLPSHAV 510
Query: 629 PVAAFRNAVFVKQLPKTRSGKIPRSALSAI 658
P V + LP T GKI S L+ I
Sbjct: 511 P----DELVLIDSLPFTSHGKIDVSELNKI 536
>gi|13325057 solute carrier family 27 (fatty acid transporter),
member 5 [Homo sapiens]
Length = 690
Score = 33.9 bits (76), Expect = 0.51
Identities = 15/39 (38%), Positives = 20/39 (51%)
Query: 534 YYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIE 572
YY+T D MD EG+LY R+ D G +S +E
Sbjct: 530 YYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVE 568
Score = 30.0 bits (66), Expect = 7.4
Identities = 26/72 (36%), Positives = 32/72 (44%), Gaps = 2/72 (2%)
Query: 293 PLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYIC 352
P +YTSGTTGLPK I V+ M S+ G +V + L V+G
Sbjct: 289 PALFIYTSGTTGLPKPAI--LTHERVLQMSKMLSLSGATADDVVYTVLPLYHVMGLVVGI 346
Query: 353 YGPLLHGNTTVL 364
G L G T VL
Sbjct: 347 LGCLDLGATCVL 358
>gi|24234699 keratin 19 [Homo sapiens]
Length = 400
Score = 33.1 bits (74), Expect = 0.88
Identities = 27/73 (36%), Positives = 32/73 (43%), Gaps = 12/73 (16%)
Query: 4 SWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRG-----CRALSSGS 58
S+ Q +S GGLGG S G G A RA P GG GGRG R +SS S
Sbjct: 5 SYRQSSATSSFGGLGG----GSVRFGPGVAFRA---PSIHGGSGGRGVSVSSARFVSSSS 57
Query: 59 GSEYKTHFAASVT 71
Y + +T
Sbjct: 58 SGAYGGGYGGVLT 70
>gi|4557809 ornithine aminotransferase precursor [Homo sapiens]
Length = 439
Score = 32.7 bits (73), Expect = 1.1
Identities = 25/79 (31%), Positives = 34/79 (43%), Gaps = 8/79 (10%)
Query: 349 SYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRA-IRQQDPGA 407
SY +GP + G + Y P A R L + VAA P A + DPG
Sbjct: 193 SYDGFGPFMPGFDIIPYNDLP-------ALERALQDPNVAAFMVEPIQGEAGVVVPDPGY 245
Query: 408 ALGKQYSLTRFKTLFVAGE 426
+G + TR + LF+A E
Sbjct: 246 LMGVRELCTRHQVLFIADE 264
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,153,780
Number of Sequences: 37866
Number of extensions: 1473204
Number of successful extensions: 4694
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 4530
Number of HSP's gapped (non-prelim): 127
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.