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Search of human proteins with 4826657
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
(538 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 1053 0.0
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 1038 0.0
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 1007 0.0
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 993 0.0
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 697 0.0
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 109 7e-24
gi|148746195 trichohyalin [Homo sapiens] 107 4e-23
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 100 3e-21
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 98 2e-20
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 95 2e-19
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 94 2e-19
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 93 5e-19
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 93 5e-19
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 92 9e-19
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 89 1e-17
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 88 2e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 86 1e-16
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 82 1e-15
gi|20070205 ladinin 1 [Homo sapiens] 81 3e-15
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 80 4e-15
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 80 4e-15
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 80 6e-15
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 80 6e-15
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 79 8e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 79 1e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 79 1e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 79 1e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 79 1e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 79 1e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 79 1e-14
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 1053 bits (2722), Expect = 0.0
Identities = 538/538 (100%), Positives = 538/538 (100%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 240
EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 240
Query: 241 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 300
GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK
Sbjct: 241 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 300
Query: 301 QKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEA 360
QKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEA
Sbjct: 301 QKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEA 360
Query: 361 AEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKI 420
AEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKI
Sbjct: 361 AEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKI 420
Query: 421 DSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKET 480
DSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKET
Sbjct: 421 DSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKET 480
Query: 481 AGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 538
AGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 481 AGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 538
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 1038 bits (2685), Expect = 0.0
Identities = 538/564 (95%), Positives = 538/564 (95%), Gaps = 26/564 (4%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQ--------------------------IKDEKIK 214
EENKKEDKEKEEEEEEKPKRGSIGENQ IKDEKIK
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 240
Query: 215 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 274
KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ
Sbjct: 241 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 300
Query: 275 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 334
VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE
Sbjct: 301 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 360
Query: 335 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 394
EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER
Sbjct: 361 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 420
Query: 395 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV 454
AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV
Sbjct: 421 AEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGV 480
Query: 455 RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP 514
RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP
Sbjct: 481 RNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRP 540
Query: 515 GDVSSKRNLWEKQSVDKVTSPTKV 538
GDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 541 GDVSSKRNLWEKQSVDKVTSPTKV 564
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 1007 bits (2603), Expect = 0.0
Identities = 514/515 (99%), Positives = 515/515 (100%)
Query: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
Query: 204 GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 263
GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS
Sbjct: 198 GENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 257
Query: 264 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 323
VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV
Sbjct: 258 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 317
Query: 324 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT 383
LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT
Sbjct: 318 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFT 377
Query: 384 PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPA 443
PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPA
Sbjct: 378 PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPA 437
Query: 444 ASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNK 503
ASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNK
Sbjct: 438 ASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNK 497
Query: 504 SPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 538
SPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Sbjct: 498 SPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV 532
Score = 53.5 bits (127), Expect = 5e-07
Identities = 56/244 (22%), Positives = 105/244 (43%), Gaps = 37/244 (15%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G+
Sbjct: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIGENQ 201
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+ E ++ P EE K+ D + F E ++ E +L+
Sbjct: 202 IKDEKIKKDKEPKEEVKSFM-------DRKKGFTEVKSQNGEFMTHKLKH---------- 244
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE-- 181
T+ + S P R DT E E + E + R E ET ++ ++K + E
Sbjct: 245 --TENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGETESEEFEKLKQKQQEAA 301
Query: 182 ------ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTE 235
+ K+E++ K EEEE+ ++ + ++++E E K +K ++R++
Sbjct: 302 LELEELKKKREERRKVLEEEEQRRKQEEADRKLREE------EEKRRLKEEIERRRAEAA 355
Query: 236 VKSQ 239
K Q
Sbjct: 356 EKRQ 359
Score = 33.5 bits (75), Expect = 0.50
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 275 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 333
Query: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 334 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 393
Query: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 394 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 450
Score = 30.8 bits (68), Expect = 3.3
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 273 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 324
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 325 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 375
Query: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
T SL ++ +Q + T + K +SR E+Y
Sbjct: 376 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 421
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 993 bits (2566), Expect = 0.0
Identities = 514/541 (95%), Positives = 515/541 (95%), Gaps = 26/541 (4%)
Query: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
+IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT
Sbjct: 18 QIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 77
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE
Sbjct: 78 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 137
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI
Sbjct: 138 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 197
Query: 204 GENQ--------------------------IKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 237
GENQ IKDEKIKKDKEPKEEVKSFMDRKKGFTEVK
Sbjct: 198 GENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 257
Query: 238 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 297
SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE
Sbjct: 258 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 317
Query: 298 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 357
KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR
Sbjct: 318 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 377
Query: 358 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 417
AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV
Sbjct: 378 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 437
Query: 418 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 477
SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN
Sbjct: 438 SKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPN 497
Query: 478 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 537
KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK
Sbjct: 498 KETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 557
Query: 538 V 538
V
Sbjct: 558 V 558
Score = 52.0 bits (123), Expect = 1e-06
Identities = 56/251 (22%), Positives = 109/251 (43%), Gaps = 25/251 (9%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E + E R+++ E E +YQ+ND D EE +E + + +E +K + S+G+
Sbjct: 144 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE--EEKPKRGSIGENQ 201
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER----RQKRLQEALERQK 119
+ + + ++ + T + E DE ++ + E + R+K E +
Sbjct: 202 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 261
Query: 120 EF---DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
EF T+ + S P R DT E E + E + R E ET ++ ++K
Sbjct: 262 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK-RLEELRRRRGETESEEFEKLK 320
Query: 177 WRDAE--------ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMD 228
+ E + K+E++ K EEEE+ ++ + ++++E E K +K ++
Sbjct: 321 QKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREE------EEKRRLKEEIE 374
Query: 229 RKKGFTEVKSQ 239
R++ K Q
Sbjct: 375 RRRAEAAEKRQ 385
Score = 33.5 bits (75), Expect = 0.50
Identities = 36/177 (20%), Positives = 77/177 (43%), Gaps = 39/177 (22%)
Query: 1 MDDFERRR--------ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ 52
+++ RRR E +QK++E LE E + +R ++ + E +RR ++E R+
Sbjct: 301 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR-EERRKVLEEEEQRRKQEEADRK 359
Query: 53 KQEEESLGQVTDQVE------VNAQNSVPDEEAKT--------TTTNTQVEGDDEAAFLE 98
+EEE ++ +++E + +P++ T + ++ ++ A FL
Sbjct: 360 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 419
Query: 99 RLARRE---------------ERRQKRLQEALERQKEFDPTITDAS-LSLPSRRMQN 139
+ ++ + R ++ A+E K PT AS L +P+ ++N
Sbjct: 420 KSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN 476
Score = 30.8 bits (68), Expect = 3.3
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 27/166 (16%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R ELRR++ E E E++ + E E ++ R+ER + +EEE
Sbjct: 299 KRLEELRRRRGETESEEFEKL---KQKQQEAALELEELKKKREERRKVLEEEEQ-----R 350
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + A + +EE K ++E R A E+RQK ++ L K+
Sbjct: 351 RKQEEADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDKKPFKC 401
Query: 125 ITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
T SL ++ +Q + T + K +SR E+Y
Sbjct: 402 FTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 447
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 697 bits (1799), Expect = 0.0
Identities = 379/543 (69%), Positives = 426/543 (78%), Gaps = 29/543 (5%)
Query: 7 RRELRRQKREEMRLEAER-IAYQRN--DDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
R L ++RE ++ E ++ IA +R + +E+ AA+ER RR +ER R ++EE+ +
Sbjct: 269 RARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEER 328
Query: 64 DQVEVNAQNS------VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALER 117
+++ + + + +EE + +++ +++ A ER R E +K E +R
Sbjct: 329 QRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR 388
Query: 118 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
K+ + + A ET K EK E + E + E + Q
Sbjct: 389 NKQLE---------------EKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVL 433
Query: 178 RDAEENK--KEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTE 235
+ E K K ++E+ +E+KP + + +IKDEKIKKDKEPKEEVKSFMDRKKGFTE
Sbjct: 434 KKQGEEKGTKVQAKREKLQEDKP---TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 490
Query: 236 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 295
VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE
Sbjct: 491 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 550
Query: 296 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 355
FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER
Sbjct: 551 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
Query: 356 RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA 415
RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA
Sbjct: 611 RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAA 670
Query: 416 IVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGT 475
IVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGT
Sbjct: 671 IVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGT 730
Query: 476 PNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSP 535
PNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSP
Sbjct: 731 PNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSP 790
Query: 536 TKV 538
TKV
Sbjct: 791 TKV 793
Score = 459 bits (1182), Expect = e-129
Identities = 286/541 (52%), Positives = 343/541 (63%), Gaps = 26/541 (4%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEE--VKSFMDRKKGFTEVKS 238
EENKKEDKEKEEEEEEKPKRGSIGENQ++ +K E +EE V S + + E K
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
Query: 239 Q------NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE 292
+ + E H+ E+ RA ++ +E E + K +E R E +
Sbjct: 241 EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK 300
Query: 293 SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEE------QRRKQEE---ADRKLREE 343
+ E+ +++ +E EE K+ EER+++ EEE+ QR K+EE A+ + R +
Sbjct: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360
Query: 344 EEKRRLKEEIERRRAEAAEK---RQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 400
EE++R EE +R RAE EK ++ L + K + KG K+E++ E K
Sbjct: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE--KVEQKIE--GK 416
Query: 401 SVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSM 460
V + + Q A++ K E+ T + + KP + E ++ K
Sbjct: 417 WVNEKKAQEDKLQTAVLKKQGE--EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
Query: 461 WEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSK 520
E+ F T K G + + E P G S K ++ P + K
Sbjct: 475 KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK 534
Query: 521 R 521
R
Sbjct: 535 R 535
Score = 37.4 bits (85), Expect = 0.035
Identities = 33/147 (22%), Positives = 66/147 (44%), Gaps = 8/147 (5%)
Query: 1 MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARE--RRRRARQERLRQKQEE 56
+++ +++RE RR+ + EE R + E + +++E+ +E RRRA RQK E
Sbjct: 565 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 624
Query: 57 ESLGQVTDQVEV---NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQE 113
+ L + + +E A+ + Q ++ + + + R ++
Sbjct: 625 DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTS 684
Query: 114 ALERQKEFDPTITDAS-LSLPSRRMQN 139
A+E K PT AS L +P+ ++N
Sbjct: 685 AIEGTKSAKPTKPAASDLPVPAEGVRN 711
Score = 32.3 bits (72), Expect = 1.1
Identities = 40/171 (23%), Positives = 70/171 (40%), Gaps = 37/171 (21%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-----DDEEEAARERRRRARQERLRQKQEEESL 59
+R ELRR++ E E E++ ++ + ++ ++ ERR+ +E R+KQEE
Sbjct: 534 KRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE--- 590
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
A + +EE K ++E R A E+RQK ++ L K
Sbjct: 591 ----------ADRKLREEEEK-RRLKEEIE--------RRRAEAAEKRQKMPEDGLSDDK 631
Query: 120 EFDPTITDASLSLP--------SRRMQNDTAENETTEKE--EKSESRQERY 160
+ T SL ++ +Q + T + K +SR E+Y
Sbjct: 632 KPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQY 682
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 109 bits (272), Expect = 7e-24
Identities = 106/488 (21%), Positives = 205/488 (42%), Gaps = 23/488 (4%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
DD ER R+ R++R E R +R E++ R+R R ++R R+K+ E +
Sbjct: 52 DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
D+ +N + E +T + ER +R+ +++ Q ERQ++
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT 171
Query: 122 D---PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+ + + RR + E E ++ SE +ER ETET T+ ++ D R
Sbjct: 172 ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTD-R 230
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKS 238
+ + +K ++E+E++ E + + + + ++DKE + E DR + E +
Sbjct: 231 ERDRQRKTEREREKQAERE---------RASERETERDKERERERDRDRDRDRRQKERER 281
Query: 239 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 298
Q + + T R R +E E + E + E R R+ ETE + EK
Sbjct: 282 QTDRKRQRRTERDRET-ERKRERQRERERERERNRKRERERERERERERQRETERDR-EK 339
Query: 299 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRA 358
++++++ E++ + ++ R + E +R ++ E DR+ E E+R + + +R R
Sbjct: 340 ERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREER--ERDRDRDRQ 397
Query: 359 EAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVS 418
+ E++ + DG + +K + + S ER + +K G + +
Sbjct: 398 KERERQTEKDRDGQRETEKQREREKDRES-----ERGRERGREREKQKGRERDRERQTDR 452
Query: 419 KIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNK 478
+ + ++ T + + SD P G+R KS E S+ G P K
Sbjct: 453 QAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIR-WKSSPEDPKAASTRFPWGRPAK 511
Query: 479 ETAGLKVG 486
+ G G
Sbjct: 512 ASRGRVAG 519
Score = 95.9 bits (237), Expect = 8e-20
Identities = 80/365 (21%), Positives = 163/365 (44%), Gaps = 24/365 (6%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
DF RRR +E R A++ D D+ E R++ R R+E+ + ++E + +
Sbjct: 25 DFSRRRP---GSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRER 81
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
+ + + + E + + + D E +R +E RQK + ER+ E
Sbjct: 82 RREKDRHRKRDRHRERQRDREKERERQTDRER---DRQREKERNRQKERERETEREGE-- 136
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
R T E++ +E +ER E + T+ ++ + R+ E+
Sbjct: 137 ------------RGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE-REREK 183
Query: 183 NKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 242
N++E +E+E + E++ K + ++ + +++ E + E K DR++ + E
Sbjct: 184 NRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERERE 243
Query: 243 FMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK 302
+ + +E R R ++ + + + +R + +R+R E E+ +++
Sbjct: 244 KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRER 303
Query: 303 QQEAALELEELKKKREERRKVLEEEEQRRKQEEADR-KLREEEEKRRLKEEIERRRAEAA 361
Q+E E E +K+ ER + E E +R+++ E DR K RE + KR+ + + ER R
Sbjct: 304 QRERERERERNRKRERERER--ERERERQRETERDREKERERKRKRQTEMDRERNRQTGR 361
Query: 362 EKRQK 366
E R++
Sbjct: 362 EGRRQ 366
Score = 75.5 bits (184), Expect = 1e-13
Identities = 84/339 (24%), Positives = 139/339 (41%), Gaps = 54/339 (15%)
Query: 41 RRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERL 100
RRR QE R++ LGQ + + + +E + Q E + + +R
Sbjct: 28 RRRPGSQESPRRR----GLGQAHKDADGDDRERNRQKERERRREKRQTERETDR---KRE 80
Query: 101 ARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERY 160
RRE+ R ++ ERQ++ + R Q D + EKE + +ER
Sbjct: 81 RRREKDRHRKRDRHRERQRDREK----------ERERQTDRERDRQREKERNRQKERER- 129
Query: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPK 220
E E + Q + R+ E + +KE+E + + + +R + Q + E+ K +E +
Sbjct: 130 ETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERR 189
Query: 221 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 280
E E K TE+ S G +E E + E ++
Sbjct: 190 ER-------------------ERQREKENKTEDRHSERGRERE---RERETETETERKRQ 227
Query: 281 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE---EAD 337
+ R R+ +TE E + KQ ++E A E E + K ER + + + RR++E + D
Sbjct: 228 TDRERDRQRKTERE---REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTD 284
Query: 338 RKL-------REEEEKRRLKEEIERRRAEAAEKRQKMPE 369
RK RE E KR + E ER R E KR++ E
Sbjct: 285 RKRQRRTERDRETERKRERQRERERER-ERNRKRERERE 322
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 107 bits (266), Expect = 4e-23
Identities = 101/428 (23%), Positives = 207/428 (48%), Gaps = 42/428 (9%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R+REL+ ++ + +LE + + +R ++++++ +R R+++LR+KQEEE Q +
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQ-----QRLRREQQLRRKQEEERREQQEE 320
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ E + +E + Q E ++ R + EERR+++L+ E ++
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQL---RREQEEERREQQLRREQEEERREQQL 377
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
+ L RR Q E + +++ +Q R E + ++ R+ EE +
Sbjct: 378 RREQQL----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 185 KEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM 244
E K ++E E++ KR E + + + +K+++E + + +R+K + + Q E
Sbjct: 434 HEQKHEQERREQRLKR----EQEERRDWLKREEETERHEQ---ERRKQQLK-RDQEEERR 485
Query: 245 THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ 304
LK E + +E + + + + EE R +R + + EE E+L+Q+ +
Sbjct: 486 ERWLKLEEE-----------ERREQQERREQQLRREQEERREQRLKRQEEE-ERLQQRLR 533
Query: 305 EAALELEELKKKREERRKVL--EEEEQRRKQEEADRKLREEEEKRR---LKEEIERRRAE 359
++L++++EERR+ L EEE+R +QE +++L+ E+E+RR LK E ERR+
Sbjct: 534 SE----QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 360 AAEKRQKMPEDGLS-DDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVS 418
++++ E L ++ + + + LK EE E + + KS + Q +
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649
Query: 419 KIDSRLEQ 426
+ R EQ
Sbjct: 650 EQQERREQ 657
Score = 105 bits (263), Expect = 8e-23
Identities = 107/423 (25%), Positives = 197/423 (46%), Gaps = 46/423 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDD---DEEEAARERRRRAR-QERLRQKQEEESLG 60
+ +L R++RE+ R + Y++ D+ +EE+ RE R + R QER RQ +EEE L
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL--ERLARREERRQKRLQEALERQ 118
Q +Q+ + + +E + + +E L E RR + R+++ +E E Q
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE-----RYEIEETETVTKSYQ 173
+E + + + + ++ E E ++EE+ R+E R E+E + Q
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177
Query: 174 KND---WRDAEENKKEDKEK---EEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFM 227
+ + R+ +E +++++E+ EEEE ++ KR ++ + +K EP++E +
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE-NAVR 1236
Query: 228 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 287
D K K + E + + E++ R ++ D + G Q +R E RR
Sbjct: 1237 DNK---VYCKGRENE----QFRQLEDSQLRDR-QSQQDLQHLLGEQQ----ERDREQERR 1284
Query: 288 RGETESEEFEKLKQKQQEAALELEELK-------KKREERRKVLEEEEQRRKQEEADRKL 340
R + F +E LE EE K K +EE++ + EE E++R+++E DRK
Sbjct: 1285 RWQQRDRHFP------EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 341 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 400
REEE+ + +EE RR E+ +K E+ L ++ K + + E +FL +
Sbjct: 1339 REEEQLLQEREEQPLRR---QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 401 SVQ 403
Q
Sbjct: 1396 EQQ 1398
Score = 105 bits (262), Expect = 1e-22
Identities = 94/480 (19%), Positives = 213/480 (44%), Gaps = 47/480 (9%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
R+ELRR+++EE + + Q+ +EE RE++ R+++ R++Q+EE Q +
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE--RRQKRLQEALERQKEFDPT 124
+ + E + Q+ + E E+ RRE+ RR+++L+ + ++E
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQ--KNDW----- 177
R + + +E++ E ++++E E E K Q + DW
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 178 ---RDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFT 234
R +E +K+ ++++EEE + + + E + ++++ +++++ + E + +++
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR---- 518
Query: 235 EVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET--- 291
+K Q E + +E R + E ++E +R + L+R + E
Sbjct: 519 -LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 292 -----ESEEFEKLKQKQQEAA---LELEELKKKREERRKVLEEEEQRRKQEEADRKLREE 343
E ++LK++Q+E L+ EE+++ +E R+ + + ++E + L+ E
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637
Query: 344 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQ 403
E++ R ++++ R + E E+R K E+ ++E+R + ++ +
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEE-----------------EERLEQRLKREHEEER 680
Query: 404 KSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEK 463
+ + Q +I SR+ ++ +E A+ +K P EG R + EK
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK--VYSRPRKQEGQRRRQEQEEK 738
Score = 103 bits (256), Expect = 5e-22
Identities = 110/446 (24%), Positives = 214/446 (47%), Gaps = 59/446 (13%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND----DDEEEAARERRRRA--------RQERLRQ 52
ER ++LR+ + + R E ++++ Q D ++E++ R+ R R RQER R+
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Query: 53 KQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD-EAAFLERLARREERRQKRL 111
+EEE L Q ++ +++ Q + + K Q+ + + F E+ R +E +K L
Sbjct: 1463 FREEEQLLQEREEQQLHRQ----ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 112 QE--ALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
+E L RQ+ + + R Q + + +EE+ + RQER EE +
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE-QLRQER---EEQQLSR 1574
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEP-------KEE 222
+ + + ++ +++++E++ E+E+ R G+ Q++ E+ +K +E +E+
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 223 VKSFMDRKKGFTEVKSQ-NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK-R 280
+R + F E + Q + +L+H + R + + +E + Q K R
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR 1694
Query: 281 LEELRRRRGETE-----------SEEFEKLKQKQQEAALELEELKKKREER-RKVLEE-- 326
EE + RR E E +E E+ +++++ E E+ + +R+ER RK+LEE
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 327 -----EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK-------RQKMPEDGLSD 374
EEQ+ +++E DRK REEE+ R+ +EE + R E+ K RQ+ E L
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Query: 375 DKKPFKCFTPKGSSLKIEERAEFLNK 400
++ K + + L++EE+ + L +
Sbjct: 1815 QQRDGK-YRWEEEQLQLEEQEQRLRQ 1839
Score = 101 bits (251), Expect = 2e-21
Identities = 103/424 (24%), Positives = 193/424 (45%), Gaps = 63/424 (14%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND-----DDEEEAARE--RRRRARQERLRQK- 53
++ E+RR RR++ +E++ E QR + +EE+ +E RRR++++R QK
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 54 ----QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK 109
+EE + T + Q + E+ +++ ++ E+ R+E+ RQ
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER----EKRRRQEQERQY 930
Query: 110 RLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
R +E L++++E L R + K++K + ++E+ EE E
Sbjct: 931 REEEQLQQEEE--------QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEP----KEEVKS 225
+ ++ +R+ EE ++E+++ EE EK +R K +++++++E + E +
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 226 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 285
+R++ + E + E +L E R KE E + E R E +
Sbjct: 1043 LQERERQYREEEELQQE--EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 286 RRRGETESEEFEKLKQKQQEAALELEELKKKR----------------EERRKVLEEEEQ 329
RRR E E + E+ + +Q+E L EE +K+R EE + + EE E+
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 330 RRKQE-------------EADRKLREEEEKRRLKEEIERRRAEAAEKRQK----MPEDGL 372
RR+QE E ++ LREE+EKRR + E + R E +++++ ED
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 373 SDDK 376
SD K
Sbjct: 1221 SDLK 1224
Score = 100 bits (250), Expect = 3e-21
Identities = 102/421 (24%), Positives = 192/421 (45%), Gaps = 65/421 (15%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQ-----EEESLG 60
RR+EL RQ REE L+ E R + ++ RER+ R +E RQK+ +E+
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 61 QVTDQVEVNAQNSVPD----------------EEAKTTTTNTQVE-----GDDEAAFLER 99
+ Q E +N+V D E+++ +Q + G+ + E+
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 100 LARREERRQKRL--QEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ 157
RR ++R + +E LER+++ + D S +++ + E + +E + R+
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK-SQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 158 ERYEIEETETVTKSYQKNDWRDAEEN-----------------KKEDKEKEEEEEEKPKR 200
E ++E E Q+ D + EE +++++E++ +EE+ R
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 201 GSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ------NGEFMTHK--LKHTE 252
E Q++ ++ +K +E ++++ S +R + F E + Q +F+ + L+
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQL-SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 253 NTFSRPGGRASVDTKEAEGAPQVEAGKRLEE---LRRRRGETESEEFEKLKQKQQEAALE 309
+ R + + +E + Q K LEE LRR+ + + E E Q+ + LE
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 310 LEELKKKREERRKVLEEEEQRRKQE-------EADRKLREEEEKRRLKEEIERRRAEAAE 362
E+ +++ +RK L+EE+Q R+QE + DRK REEE+ R+ +EE + R E
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDR 1579
Query: 363 K 363
K
Sbjct: 1580 K 1580
Score = 100 bits (249), Expect = 3e-21
Identities = 104/423 (24%), Positives = 204/423 (48%), Gaps = 54/423 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQER----LRQKQEEESLG 60
E RRE +R KREE E ER +++EE +++ RR +QER L++++EEE L
Sbjct: 613 EERRE-QRLKREEP--EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 61 Q--VTDQVEVNAQNSVPDEE---------AKTTTTNTQVEGDDEAAFLERLAR-REERRQ 108
Q + E + + +EE ++ Q+E + +A + +R R++ Q
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 109 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT---EKEEKSESRQERY----- 160
+R QE E+++ + + R+ Q + + T + EEKSE ++R
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789
Query: 161 --EIEETETVTKSYQKNDWRD-AEENKKEDKEKEEEEEEKPKRGSIGENQI-KDEKIKKD 216
E E + + Q+ + R EE +KE + ++ E EK + E Q+ + E+ ++
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 217 KEPKEEVKSFMDRKKGFTEVKSQNGEFM--THKLKHTENTFSRPGGRASVDTKEAEGAPQ 274
+E ++ ++ +R++ + + Q + + + +++P + + ++ +
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909
Query: 275 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR------------- 321
E +R E +RRR E E + E+ + +Q+E L EE +K+R + R
Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 322 --KVLEEEEQRRKQEEADRKLREE-----EEKRRLKEEIERRRAEAAEKRQKMPEDGLSD 374
++L EE ++R+++E ++K REE EE++ L+EE E+RR + E RQ +D L
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE-RQYRKKDELQQ 1028
Query: 375 DKK 377
+++
Sbjct: 1029 EEE 1031
Score = 100 bits (249), Expect = 3e-21
Identities = 86/387 (22%), Positives = 179/387 (46%), Gaps = 28/387 (7%)
Query: 5 ERRRELRRQKR------EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
E + LRRQ+R EE +L + Q D + + E ++ +RQER R+ +EEE
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE- 1436
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
QV + EE + + +E L+ ++ RQ+R ++ LE +
Sbjct: 1437 -----QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERY--EIEETETVTKSYQKND 176
++ D R Q + E++ + RQ ++ E ++ + Q+
Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ 1551
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKE--EVKSFMDRKKGFT 234
RD + ++E +E EE++ ++ + +++++K+++ ++ ++ E + + R++G
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 235 EVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE 294
+++ + + + + R D K E PQ+ +R ++LR R E
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 295 --------EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK 346
E ++L++++++ EE + +R+ER + +EEQ+ +++E +RK REEE+
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 347 RRLKEEIERRRAE----AAEKRQKMPE 369
R+ E+ + RR E E+ Q PE
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPE 1758
Score = 99.8 bits (247), Expect = 6e-21
Identities = 94/361 (26%), Positives = 168/361 (46%), Gaps = 39/361 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDD---DEEEAARERR-RRARQERLRQKQEEESLG 60
E EL+R++RE+ R + + Y+ + +EE+ RE R +R RQER RQ ++++ L
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Q +Q+ E+ + + ++E E REER ++R QE + ++
Sbjct: 968 QKEEQLL-----GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI-EETETVTKSYQKNDWRD 179
D + L R + E E +EE+ ++E + EE ET + + +R
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 239
EE ++E+++ EE EK +R E Q ++E+ + +E E++ K+ E++ Q
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQE-RERQCREEEELQQEE--EQLLREEREKRRRQELERQ 1139
Query: 240 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKL 299
E E E + E R E +RRR E E + E+
Sbjct: 1140 YRE-------------------------EEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 300 KQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 359
+ +Q+E L EE +K+R+ER + EEE+ ++Q+ R R+E+++ LK + E +
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR-YRDEDQRSDLKWQWEPEKEN 1233
Query: 360 A 360
A
Sbjct: 1234 A 1234
Score = 99.8 bits (247), Expect = 6e-21
Identities = 83/361 (22%), Positives = 167/361 (46%), Gaps = 14/361 (3%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+ R + RRQ R+ E E++ +R + R+R+ R ++++R++++E +
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 65 QVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEA--LERQKEF 121
Q+ Q + E + + Q+ + E E+ R+ER +K L+E L RQ+
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQERE----EQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSES-RQERYEIEETETVTKSYQKNDWRDA 180
D E + ++E+ R+E ++ E K Q+
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 181 EENKKEDKEKE----EEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
+E +++ +E+E E E+E+ +R +++E+++ ++E ++ + DRK E
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
Q E + + ++ F R + + +E + PQ GK E + + E + +
Sbjct: 1779 LRQEREEQQLRSQESDRKF-REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL 1837
Query: 297 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 356
+ + +Q A + +K R E +++ +EEEQ+R+QE +RKLREE +R+ KEE R
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER-ERKLREEHIRRQQKEEQRHR 1896
Query: 357 R 357
+
Sbjct: 1897 Q 1897
Score = 99.4 bits (246), Expect = 7e-21
Identities = 103/395 (26%), Positives = 184/395 (46%), Gaps = 48/395 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E RRE + ++ +++R E E QR EEE ++R R+ Q+ LR++QEE +
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ-LRREQEERREQLLKR 552
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRL----QEALERQKE 120
+ E + ++ K Q E D+ L R EERRQ+RL +E LE++ +
Sbjct: 553 EEEKRLEQERREQRLK----REQEERRDQL-----LKREEERRQQRLKREQEERLEQRLK 603
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ +R++ + E E ++ KSE ++ER + + + ++ R+
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE 663
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEE--VKSFMDRK--KGFTEV 236
EE + E + K E EEE+ ++ E Q + + K + PK + ++S D + K ++
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723
Query: 237 KSQNG----------------------EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 274
+ Q G E H+ + E + + K G +
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 275 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK---VLEEEEQRR 331
+ A L E R R + +EE ++ +Q+ E E+ +++R ER K LEEEEQ +
Sbjct: 784 LSARPPLREQRER--QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841
Query: 332 KQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
++E A ++L+EEE+ L+E+ ERRR++ + QK
Sbjct: 842 RRERA-QQLQEEEDG--LQEDQERRRSQEQRRDQK 873
Score = 99.0 bits (245), Expect = 1e-20
Identities = 87/374 (23%), Positives = 190/374 (50%), Gaps = 24/374 (6%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ERR + R+++EE R E + Q + E++ RE++ R R+++LR++Q+ Q+
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR-REQQLRREQQLRREQQLRR 403
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ ++ + + E+ + E ++E +ERR++RL+ E ++++
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEER---HEQKHEQERREQRLKREQEERRDWLKR 460
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERY-EIEETETVTKSYQKNDW-RDAEE 182
+ RR Q K ++ E R+ER+ ++EE E + ++ R +E
Sbjct: 461 EEETERHEQERRKQQ--------LKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 183 NKKEDKEKEEEEEEKPKRGSIGENQIK-DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
++E + K +EEEE+ ++ E Q++ +++ ++++ K E + +++++ +K +
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEA----EGAPQVEAGKRLEELRRRRGETESEEFE 297
E LK E + R + E E ++E +R E+ R +R E E E +
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ-RLKREEPEEERRQ 631
Query: 298 KLKQKQQEAALELEELKKKREERRKV-LEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 356
+L + +++ ++L+++++ERR+ L+ EE+ + E+ R RE EE+RR +E E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ--RLKREHEEERREQELAEEE 689
Query: 357 RAEAAEK-RQKMPE 369
+ +A E+ + ++P+
Sbjct: 690 QEQARERIKSRIPK 703
Score = 98.6 bits (244), Expect = 1e-20
Identities = 102/399 (25%), Positives = 189/399 (47%), Gaps = 55/399 (13%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
RR+E RQ REE L+ E +E+ ER +R RQE RQ +EEE + Q +Q
Sbjct: 1102 RRQERERQCREEEELQQE---------EEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFL--ERLARREER-RQKRLQEALERQK--- 119
+ +E + + +E L E+ RR+ER RQ R +E L+RQK
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 120 -------------EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE--SRQERYEIE- 163
+++P +A + ++ ENE + E S+ RQ + +++
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENA---VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Query: 164 ---ETETVTKSYQKNDWRDAEENKKEDKEKE-EEEEEKPKRGSIGENQ---IKDEKIKK- 215
E + + ++ W+ + + E+++ E EE++E +R + + +++E+ +K
Sbjct: 1270 LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKR 1329
Query: 216 -----DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVD 265
D++ +EE + +R++ + ++ +F +L+H E + R +
Sbjct: 1330 RRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE 1389
Query: 266 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER-RKVL 324
K + Q+ +R ++LR+ R EE ++L +++++ EE + +R+ER RK L
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFL 1449
Query: 325 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 363
EEE+Q R +E RK REEE+ + +EE + R E K
Sbjct: 1450 EEEQQLR--QERHRKFREEEQLLQEREEQQLHRQERDRK 1486
Score = 97.4 bits (241), Expect = 3e-20
Identities = 94/416 (22%), Positives = 188/416 (45%), Gaps = 57/416 (13%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDE---EEAARERRRRARQERLRQKQEEES 58
++ R ++LRR++ EE R + R Q + + E+ R ++ R+++LR++Q+
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQV----EGDDEAAFLERLARREERRQKRLQEA 114
Q+ + ++ + E K + E ++ +L+R E Q+R ++
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETT-EKEEKSESRQERYEIEETETVTKSYQ 173
L+R +E + L RR Q + E + E+EE+ E R +R E EE +
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 174 KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGF 233
+ R+ EE +++ ++EEE+ + +R +++++K+++E + + + ++
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQER--------REQRLKREQEERRDQLLKREEERRQ 587
Query: 234 TEVKSQNGEFMTHKLKHTE----NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR-- 287
+K + E + +LK E R R + E E Q+ + EE R++
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 288 RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLE--EEEQR--------------- 330
R E + ++LK++++E LE + LK++ EE R+ E EEEQ
Sbjct: 648 RREQQERREQRLKREEEEERLE-QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706
Query: 331 -----------------RKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 369
RKQE R+ +EE++RR + E++ + E A ++Q+ E
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Score = 97.4 bits (241), Expect = 3e-20
Identities = 99/420 (23%), Positives = 192/420 (45%), Gaps = 55/420 (13%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER + RRQ+ + E E++ +R +++ +ER R+ R+E LR +++ +
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQER--EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 65 QV---EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE---RLARREERRQKRLQEALERQ 118
++ E + +++ + Q+ D + F E +L+R+E R+ R +E R+
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETT-EKEEKSESRQERYE--IEETETVTKSYQKN 175
+E + + L R + E + E+EE+ RQER +EE + + + +
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Query: 176 DWRDAEENKKEDKEK--EEE--------------EEEKPKRGSIGENQIKD--------E 211
+R+ E +E + K EEE EE++ +R G+ + +D E
Sbjct: 1502 KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 212 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV----DTK 267
++++++E ++ + DRK E K + E K E R G+ + D K
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQE-QERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Query: 268 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 327
E ++ + + R+ R EE +L+++++E L + +K REE + + E E
Sbjct: 1621 FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE 1680
Query: 328 EQRRKQEEADRKLREEEEKRRLKE---------------EIERRRAEAAEKRQKMPEDGL 372
EQ+ +++E DRK REEE++ R +E E+ER+ E + RQ+ ++ L
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Score = 95.5 bits (236), Expect = 1e-19
Identities = 104/395 (26%), Positives = 185/395 (46%), Gaps = 42/395 (10%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
R R R + + +LE+E A Q +RRR QE R+++E E Q ++
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR---REER-RQKRLQEALERQKEF 121
Q +E+ + T Q E E AR RE+R RQ R +E +R++ F
Sbjct: 754 AHRQQQE---EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810
Query: 122 DPTITDASLSLPSRRMQNDTAENETT--EKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
P + RR Q E E E+EE+ + R+ +++E E + Q+ R
Sbjct: 811 LPEEEEKE----QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER--RR 864
Query: 180 AEENKKEDKEKEE-EEEEKPKRGSIGENQIKDEKIKKDK----EPKEEVKSFMDRKKGFT 234
++E +++ K + + EEE K +R ++ E+++K++ E +EE++ K+
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 235 EVKSQNGEFMTHKLKHTENTFSRPGG---------RASVDTKEAEGAPQVEAGKRLEELR 285
E + Q E +L+ E R R K+ + + G+ E+ R
Sbjct: 925 EQERQYRE--EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 286 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK---QEEADRKLRE 342
R+ E + E E+L+Q++++ L+++RE+RR+ E + R+K Q+E ++ LRE
Sbjct: 983 RQEREKKYREEEELQQEEEQL------LREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 343 EEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 377
E EKRRL+E + R E E+ Q+ E L ++++
Sbjct: 1037 EREKRRLQERERQYREE--EELQQEEEQLLGEERE 1069
Score = 92.4 bits (228), Expect = 9e-19
Identities = 90/414 (21%), Positives = 190/414 (45%), Gaps = 48/414 (11%)
Query: 1 MDDFERRR-ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLR-------- 51
+D+ +R R + + ++ R E ++ ++ D EE +RRR+ RQE+ R
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 52 -QKQE----------EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF---- 96
+KQE +E L + + + + +E+ ++ + E DE
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 97 ---LERLARREERRQKRLQE--ALERQKEFDPTITDASLSLPSRRMQND--------TAE 143
L R R E+++Q+R ++ + ++E + + L ++Q + E
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
E K E+ E R+ER E E+ + + Q+ + EE +++ +E+ E++E + ++
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 204 GENQIKDEKIKKDKE----PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPG 259
E Q++ E+ ++ ++ +EE + ++ E + + +L+ +
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Query: 260 GRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 319
R + + + + +R ++LRR + +E E+ +QK ++ E + LK+++EE
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE-QRLKREQEE 453
Query: 320 RRKVLEEEEQRRKQEEADRK---LREEEEKRR---LKEEIERRRAEAAEKRQKM 367
RR L+ EE+ + E+ RK R++EE+RR LK E E RR + + Q++
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Score = 92.4 bits (228), Expect = 9e-19
Identities = 98/389 (25%), Positives = 185/389 (47%), Gaps = 53/389 (13%)
Query: 6 RRRELRRQKREEMRLEAERIAY----QRNDDDEEEAAR--ERRRRARQERLRQKQEEESL 59
R +ELR Q+ E LE E+ + QR EE+ R ER ++ RQ+R R+ +EEE L
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE-RQ 118
Q ++ +++ Q E D + E+ RR+E+ +K +++ + R+
Sbjct: 1564 RQEREEQQLSRQ-----------------ERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE--IEETETVTKSYQKND 176
+E + R+ + D E E+EE+ RQER +EE + +
Sbjct: 1607 QEGQQQLRQER----DRKFRED--EQLLQEREEQQLHRQERDRKFLEEEPQLRR------ 1654
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
++ E+ + D++++ EEE+ + + + E+ +K +E +++++ +K E
Sbjct: 1655 -QEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 237 KSQNGEFMTHKLKH-------TENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 289
+ + + K + TE R R +E + P+ E ++LRR+
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE----QQLRRQER 1769
Query: 290 ETESEEFEKLKQKQQEAALELEELKKK-REERRKVLEEEEQRRKQEEADRKLREEEEKRR 348
+ + E E+L+Q+++E L +E +K REE + E EEQ+ + ++ D K R EEE+ +
Sbjct: 1770 DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Query: 349 LKEEIERRRAEAAEKRQKMPEDGLSDDKK 377
L+E+ +R R E RQ E+ + +K
Sbjct: 1830 LEEQEQRLRQE--RDRQYRAEEQFATQEK 1856
Score = 88.6 bits (218), Expect = 1e-17
Identities = 83/392 (21%), Positives = 184/392 (46%), Gaps = 51/392 (13%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQK---QEEES 58
++ +RR E R ++ EE + R Q+ + E E A + +QERL Q+ + +E
Sbjct: 116 EEDQRRFEPRDRQLEEEPGQRRR---QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEE 172
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARRE--ERRQKRLQEALE 116
L + + + + +E+ ++ + E DE E+L RRE E R+K +E +
Sbjct: 173 LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE----EQLRRRELLELRRKGREEKQQ 228
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+++E ++ ++EE+ E R+ + + E + +
Sbjct: 229 QRRE---------------------RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 177 WRDAEEN-------KKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR 229
R+ +E ++++ +E +EEE+ ++ E Q++ ++ ++ +E +EE + +R
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 230 KKGFTE-----VKSQNGEFMTHKLKHTENTFSRPG--GRASVDTKEAEGAPQVEAGKRLE 282
++ E ++ + E +L+ + R R + + + + + +R +
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 283 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE--EQRRKQEEADRKL 340
+LRR + ++ + +Q ++E L E+ ++ ++ R+ EEE EQ+ +QE +++L
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 341 REEEEKRR--LKEEIERRRAEAAEKRQKMPED 370
+ E+E+RR LK E E R E ++Q++ D
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRD 479
Score = 72.8 bits (177), Expect = 8e-13
Identities = 74/278 (26%), Positives = 129/278 (46%), Gaps = 48/278 (17%)
Query: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 161
RR+E Q+R E +RQ E +P RR + E E E EE+SE +QER E
Sbjct: 113 RRQEEDQRRF-EPRDRQLEEEPG--------QRRRQKRQEQERELAEGEEQSE-KQERLE 162
Query: 162 IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKE 221
+ + + WR +E ++ ++ + EEE+ + +G E + DE+ + +E E
Sbjct: 163 QRDRQRRDEEL----WRQRQEWQEREERRAEEEQLQSCKGHETE-EFPDEEQLRRRELLE 217
Query: 222 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL 281
R+KG E + Q E + E + E KR
Sbjct: 218 L------RRKGREEKQQQRRERQDRVFQEEE---------------------EKEWRKRE 250
Query: 282 EELRRRRGETESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEEQRRKQEEADRK 339
LR+ + + EE Q+Q+E E E+L+K ++E RR+ EEE+Q+++ +
Sbjct: 251 TVLRKEEEKLQEEE----PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 340 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 377
R++EE+RR ++E R + E E++++ E L +++
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Score = 53.1 bits (126), Expect = 6e-07
Identities = 44/181 (24%), Positives = 89/181 (49%), Gaps = 19/181 (10%)
Query: 211 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 270
E + +D+ +E+ + F R + +++ + G+ K + E + +++ E
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDR---QLEEEPGQRRRQKRQEQERELAE----GEEQSEKQE 159
Query: 271 GAPQVEAGKRLEELRRRRGE--------TESEEFEKLKQKQQEAALELEELKKKR--EER 320
Q + +R EEL R+R E E E+ + K + E + E+L+++ E R
Sbjct: 160 RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELR 219
Query: 321 RKVLEEEEQRRKQEEADRKLREEEEKR-RLKEEIERRRAEAAEKRQKMPEDGLSDDKKPF 379
RK EE++Q+R+ E DR +EEEEK R +E + R+ E ++ + + L ++++
Sbjct: 220 RKGREEKQQQRR-ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 380 K 380
+
Sbjct: 279 R 279
Score = 50.4 bits (119), Expect = 4e-06
Identities = 57/241 (23%), Positives = 104/241 (43%), Gaps = 75/241 (31%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
+ +LRRQ+R LE E++ +R +E++ R QER R+ +EEE L Q ++
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPER---EEQQLRR-------QERDRKFREEEQLRQEREEQ 1786
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER-RQKRLQEALERQKEFDPTI 125
++ +Q S +R R EE+ RQ+R ++ L Q
Sbjct: 1787 QLRSQES------------------------DRKFREEEQLRQEREEQQLRPQ------- 1815
Query: 126 TDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK 185
+++ K +E+ ++EE E + + +R E+
Sbjct: 1816 ----------------------QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853
Query: 186 EDKEKEEE----EEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
++K + EE +EE+ KR E ++++E I+ ++ KEE R + E+KSQ G
Sbjct: 1854 QEKSRREEQELWQEEEQKRRQERERKLREEHIR--RQQKEE-----QRHRQVGEIKSQEG 1906
Query: 242 E 242
+
Sbjct: 1907 K 1907
Score = 45.1 bits (105), Expect = 2e-04
Identities = 40/155 (25%), Positives = 77/155 (49%), Gaps = 14/155 (9%)
Query: 284 LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE---EADRKL 340
L+ RR E + FE + +Q E +K++E+ R++ E EEQ KQE + DR+
Sbjct: 110 LQDRRQEEDQRRFEP-RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 341 REEEEKRRLKE--EIERRRAEAAE-------KRQKMPEDGLSDDKKPFKCFTPKGSSLKI 391
R+EE R+ +E E E RRAE + + ++ P++ ++ + KG K
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE-LRRKGREEKQ 227
Query: 392 EERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 426
++R E ++ Q+ + + ++ K + +L++
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Score = 36.2 bits (82), Expect = 0.078
Identities = 18/76 (23%), Positives = 39/76 (51%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E+ + LR+++ + R E + +++ +E+E +E ++ RQER R+ +EE Q +
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE 1891
Query: 65 QVEVNAQNSVPDEEAK 80
+ + +E K
Sbjct: 1892 EQRHRQVGEIKSQEGK 1907
Score = 29.3 bits (64), Expect = 9.5
Identities = 20/71 (28%), Positives = 40/71 (56%), Gaps = 5/71 (7%)
Query: 307 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
A L+E K+ R + ++ L ++ R+QEE R+ E R+L+EE +RR + +++++
Sbjct: 92 ATGLDEEKRARCDGKESLLQD---RRQEEDQRRF--EPRDRQLEEEPGQRRRQKRQEQER 146
Query: 367 MPEDGLSDDKK 377
+G +K
Sbjct: 147 ELAEGEEQSEK 157
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 100 bits (249), Expect = 3e-21
Identities = 102/437 (23%), Positives = 202/437 (46%), Gaps = 44/437 (10%)
Query: 6 RRRELR-RQKREEMRLEAERIAYQRNDDDEEEAARERRRRA--RQERLRQKQE-----EE 57
RR+E R R++ +E+R + + + Q+ ++EE +E+ + ++E++R+++E EE
Sbjct: 279 RRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 338
Query: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK--RLQEAL 115
L + Q+ Q EE E ++ E++ +EE+ Q+ R++E
Sbjct: 339 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRERE 398
Query: 116 ERQKEFDPTITDASLSLPSR------------RMQNDTAENETTEKEEKSESRQER-YEI 162
++ +E + T+ + + + + Q + E ++EK + ++E+ +E
Sbjct: 399 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 458
Query: 163 EET---ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIK----DEKIK- 214
EE + +K WR + ++ED+ E+EE+ + + + + + + DE+++
Sbjct: 459 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518
Query: 215 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 274
K++ +E+ K + +K E K+Q E T + R R +E E +
Sbjct: 519 KEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 578
Query: 275 VEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE----EQR 330
E + +E + R E + E E+ Q+Q+E E EE ++EE K+ E+E EQ
Sbjct: 579 QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE 638
Query: 331 RKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLK 390
K +E + K+ E+EEK R +EE + E EK Q E ++K +G K
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEE---KMREQEEKMQGQEEKMREQEEK------MQGQEEK 689
Query: 391 IEERAEFLNKSVQKSSG 407
+ E+ E + +K G
Sbjct: 690 MREQEEKMRGQEEKMWG 706
Score = 94.4 bits (233), Expect = 2e-19
Identities = 105/428 (24%), Positives = 199/428 (46%), Gaps = 46/428 (10%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ R+ E R++ +++R + E++ Q EE RE+ + R++ + +++E+ L +
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQ------EERLREQEGKMREQEEKMRRQEKRLRE 287
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF---------LERLARREER-----R 107
+ E+ Q E+ K Q++ +E + E++ R+EER +
Sbjct: 288 --QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345
Query: 108 QKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET 167
Q R QE R +E D L RM+ E EK ++ E +ER + E
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE 405
Query: 168 VTKSYQKNDWRDAEENKKEDKEKEEEE----EEKPKRGSIGENQIKDEKIKKDKE---PK 220
T Q+ + EEN E +EKE ++ E+K K + Q ++EKI + +E +
Sbjct: 406 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Query: 221 EEV---KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 277
EE+ + M R++ E + Q E + + + D + E ++
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMRE 525
Query: 278 GKRL-EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 336
K++ ++ + R E +++E EK Q+E ++ E ++ RE +K+ EEEE R+QEE
Sbjct: 526 QKKMWQQEEKMREEKKTQEQEKKTWDQEE---KMREEERMREREKKMREEEEMMREQEE- 581
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
K++E+EEK R +EE + E EK Q+ E ++K ++ + K++E+ E
Sbjct: 582 --KMQEQEEKMREQEE---KMWEQEEKMQEQEEKMWEQEEKMWE----QEEEDKMQEQEE 632
Query: 397 FLNKSVQK 404
+ + +K
Sbjct: 633 MMWEQEEK 640
Score = 92.8 bits (229), Expect = 7e-19
Identities = 88/384 (22%), Positives = 180/384 (46%), Gaps = 32/384 (8%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ----VTD 64
E R+K E MR E E++ Q EEE RER ++ R+E +++EE + + + +
Sbjct: 366 ERLREKEERMR-EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 65 QVEVN-AQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---------RQKRLQEA 114
Q E Q +P+++ K E +++ E R +E RQ++++E
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET---ETVTKS 171
++ E + + D + + + + EKEE+ +++ ++ EE E T+
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 172 YQKNDWRDAEENKKEDKEKEEE----EEEKPKRGSIGENQIKDEKIKKDKEP--KEEVKS 225
+K W E+ ++E++ +E E EEE+ R + Q ++EK+++ +E ++E K
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKM 604
Query: 226 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 285
+K + + + + K++ E + +E E + K E+
Sbjct: 605 QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM----QEQEEKMWEQEEKMREQEE 660
Query: 286 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 345
+ R + E + ++ K ++QE ++ +E +K RE+ K+ +EE+ QEE K+ +EE
Sbjct: 661 KMREQEEKMQGQEEKMREQEEKMQGQE-EKMREQEEKMRGQEEKMWGQEE---KMWGQEE 716
Query: 346 KRRLKEEIERRRAEAAEKRQKMPE 369
K +EE+ + ++++KM E
Sbjct: 717 KMWGQEEMREKEERIRDQKEKMQE 740
Score = 67.4 bits (163), Expect = 3e-11
Identities = 68/322 (21%), Positives = 137/322 (42%), Gaps = 19/322 (5%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ +EE K Q ++ E + K L+ LER K P + +L
Sbjct: 177 RNTITNEELKKKNAELQ----EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL 232
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK 190
R + + E E ++++ + ++ + E E + ++ R + ++++KE
Sbjct: 233 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL 292
Query: 191 EEEE----EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 246
E+E E+K R + Q ++EK+ + +E E + M R++ + +
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 247 KLKHTENTFSRPGGRASVDTK---------EAEGAPQVEAGKRLEELRRRRGETESEEFE 297
K++ E R + E E Q E R E + R E E E
Sbjct: 353 KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQE 412
Query: 298 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEI--ER 355
+ QKQ+E E EE + +++ + E+ ++ K +E + K+ E+EEK R +EE+ +
Sbjct: 413 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472
Query: 356 RRAEAAEKRQKMPEDGLSDDKK 377
++ EK ++ + ++K
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEK 494
Score = 66.2 bits (160), Expect = 7e-11
Identities = 70/332 (21%), Positives = 144/332 (43%), Gaps = 60/332 (18%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
R+E R++ ++M + E++ D +++ +E R + ERLR+K+E ++ +Q
Sbjct: 477 RQEKMREQEDQMWEQEEKM----RDQEQKMWDQEERMWEQDERLREKEE-----RMREQK 527
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
++ Q EE KT + +E E R E++ + +E + Q+E
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE------ 581
Query: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186
+ + + E + E+EEK + ++E+ E+ E + + +++ ++ EE E
Sbjct: 582 ----KMQEQEEKMREQEEKMWEQEEKMQEQEEKM-WEQEEKMWEQEEEDKMQEQEEMMWE 636
Query: 187 DKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 246
+EK +E+EEK E+ +K +E +E+++ ++ +G E
Sbjct: 637 QEEKMQEQEEK-----------MWEQEEKMREQEEKMREQEEKMQGQEE----------- 674
Query: 247 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 306
+E E Q + K E+ + RG+ E ++ K QE
Sbjct: 675 ------------------KMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEE 716
Query: 307 ALELEELKKKREERRKVLEEEEQRRKQEEADR 338
+ +E +++EER + +E+ Q R E +R
Sbjct: 717 KMWGQEEMREKEERIRDQKEKMQERLPEHEER 748
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/225 (22%), Positives = 108/225 (48%), Gaps = 12/225 (5%)
Query: 5 ERRRELRR--QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
ER RE ++ Q+ E+MR E + ++ D+EE RE R +E+ + ++EEE + +
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQ 579
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
++++ + + ++E K +++ +E + + E+ + ++QE E E +
Sbjct: 580 EEKMQ-EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE 638
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
+ + + + + E + E+EEK + ++E+ +E + Q+ R+ EE
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEK---MQGQEEKMREQEE 695
Query: 183 NKKEDKEKEEEEEEK-----PKRGSIGENQIKDEKIKKDKEPKEE 222
+ +EK +EEK K E + K+E+I+ KE +E
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 59.3 bits (142), Expect = 9e-09
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 23/212 (10%)
Query: 183 NKKEDKEKEEEEEEKPKRG-SIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV----- 236
+KK D+ EE +E+ + N I +E++KK +E + +K ++
Sbjct: 154 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL 213
Query: 237 --KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK---RLEELRRRRGET 291
K + +F+ +++ NT R + +E E + + K + E LR + G+
Sbjct: 214 KRKLERAKFLLPQVQ--TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 271
Query: 292 ESEEFEKLKQKQQ---EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR 348
+E EK++++++ E EL E +K+ E++K+ E+EEQ ++QEE K+ E+EEK R
Sbjct: 272 REQE-EKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEE---KMWEQEEKMR 327
Query: 349 LKEEIERRRAE---AAEKRQKMPEDGLSDDKK 377
+EE R+ E EK+ + E + D ++
Sbjct: 328 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Score = 53.9 bits (128), Expect = 4e-07
Identities = 46/198 (23%), Positives = 91/198 (45%), Gaps = 18/198 (9%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRA-RQERLRQKQEEESL 59
M + ER RE ++ REE + E+ + ++EE RE+ + QE Q+QEE+
Sbjct: 556 MREEERMREREKKMREEEEMMREQ---EEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 612
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF-LERLARREERRQKRLQEALERQ 118
Q E ++ + ++E +++ +E + E R +E + + +E ++ Q
Sbjct: 613 EQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ 672
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETE---TVTKSYQKN 175
+E + +MQ E + E+EEK ++E+ +E + K + +
Sbjct: 673 EE--------KMREQEEKMQGQ--EEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQE 722
Query: 176 DWRDAEENKKEDKEKEEE 193
+ R+ EE ++ KEK +E
Sbjct: 723 EMREKEERIRDQKEKMQE 740
Score = 45.8 bits (107), Expect = 1e-04
Identities = 70/324 (21%), Positives = 136/324 (41%), Gaps = 66/324 (20%)
Query: 133 PSRRMQNDTAENETTEKEEK-SESRQERYE-IEETETVTKSYQKNDWRDAEE------NK 184
P M T +N+ E ++K ++ RQ + T TK + N+ + E +
Sbjct: 9 PHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSEGCHS 68
Query: 185 KEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFM----DRKKGFTEVKSQN 240
ED++K + ++ R I + +D I+ K E+++ + D + F +
Sbjct: 69 PEDEKKASHQHQEALRREI---EAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGE 125
Query: 241 GEFMTHKLKHT-------------ENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EEL 284
+ + +L H+ +T+ + R + + A +E + EEL
Sbjct: 126 SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEEL 185
Query: 285 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL-------------------- 324
+++ E + E+ + ++ E L ++ELK+K E + +L
Sbjct: 186 KKKNAELQ-EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR 244
Query: 325 EEEEQRRKQEE----ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 380
E+E++ RKQEE + +LRE+E K R +EE RR+ EKR + E L + +K +
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQ----EKRLREQEKELREQEKELR 300
Query: 381 CFTPKGSSLKIEERAEFLNKSVQK 404
K+ E+ E + + +K
Sbjct: 301 ------EQKKLREQEEQMQEQEEK 318
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 98.2 bits (243), Expect = 2e-20
Identities = 93/424 (21%), Positives = 197/424 (46%), Gaps = 38/424 (8%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAA---RERRRRARQERLRQKQEE-ESLGQV 62
+ E R++ E+M + ER+ Q E+E +E R + ERLR+K+E ++
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKM 419
Query: 63 TDQVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE- 120
+QVE + + + ++E KT +++ ++ E+ R EE + +E +++Q+E
Sbjct: 420 WEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 121 -FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
++ + + + + + E+EEK ++E+ +E +K WR
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW---GQEKKMWRQ 536
Query: 180 AEENKKEDKEKEEEE--------------------EEKPKRGSIGENQIKDEKIKKDKEP 219
+ ++ED+ E+EE +E+ K+ E ++++E+ +++E
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
Query: 220 K--EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 277
K EE + ++++ E + + E + E + + K E ++
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
Query: 278 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE--- 334
+RL E + + E E + ++ Q+Q+E E E+++KK +E+ K ++E+ R++E
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR 716
Query: 335 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 394
E ++K+REEEE R +EE + E EK Q+ E+ ++K ++ ++ E+
Sbjct: 717 EREKKMREEEEMMREQEE---KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ 773
Query: 395 AEFL 398
E L
Sbjct: 774 KEKL 777
Score = 97.8 bits (242), Expect = 2e-20
Identities = 100/397 (25%), Positives = 187/397 (47%), Gaps = 42/397 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND--DDEEEAARERRRRARQERLRQKQEEESLGQV 62
E+ +++R+Q+ E+M + ER+ Q + EE+ R+ +R QE+ ++QE+E +
Sbjct: 283 EQEKKIRKQE-EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKE----L 337
Query: 63 TDQVEVNAQ-NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+Q E+ Q + ++E K ++ +E + + E+ +Q R QE R +E
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 122 DPTITDASLSLPSRRMQND----------TAENETTEKEEKSESRQERYEIEE------- 164
D L RM+ E + E+E+K+ ++E+ + EE
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
Query: 165 ---TETVTKSYQKNDWRDAEENKKEDKEKEEEE----EEKPKRGSIGENQIKDEKI-KKD 216
E T Q+ + EEN E +EKE ++ E+K K + Q ++EKI +++
Sbjct: 458 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
Query: 217 KEPKEEVKSFMDRKKGFTEVKSQNGE----FMTHKLKHTENTFSRPGGRASVDTKEAEGA 272
++ +++ + + KK + + K + E K++ E R T+E E
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK 577
Query: 273 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK 332
+ K EE R R E + E E++ ++Q+E E EE K +E+ K+ E+EE+ ++
Sbjct: 578 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE--KMQEQEEKMWEQEEKMQE 635
Query: 333 QEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 369
QEE K+ E+EEK +EE + E+++K+ E
Sbjct: 636 QEE---KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Score = 85.9 bits (211), Expect = 9e-17
Identities = 83/369 (22%), Positives = 173/369 (46%), Gaps = 46/369 (12%)
Query: 4 FERRRELRRQKR----EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+E+ ++R Q++ +E R+E + ++ D+EE RE R +E+ + ++EEE +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMM 605
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ ++++ + + ++E K +++ +E + + E+ + Q+ L QK
Sbjct: 606 REQEEKMQ-EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK 664
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKNDW- 177
E E+E +++EK + ++E+ +E E+ E T+ +K W
Sbjct: 665 E-------------------KLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD 705
Query: 178 --RDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEP--KEEVKSFMDRKKGF 233
+ EE ++EK+ EEE+ R + Q ++EK+++ +E ++E K + +K +
Sbjct: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765
Query: 234 TEVK--SQNGEFMTH-KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE 290
+ + Q + H K++ E + + E + Q E + EE + RG+
Sbjct: 766 EQQRLPEQKEKLWEHEKMQEQEKIWEQ----------EEKMRDQEEKMRGQEE--KMRGQ 813
Query: 291 TESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLK 350
E ++ K QE + +E K +E + +EE+ K + + K+RE+EEK R +
Sbjct: 814 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ 873
Query: 351 EEIERRRAE 359
EE R + E
Sbjct: 874 EEKMREQEE 882
Score = 85.1 bits (209), Expect = 1e-16
Identities = 89/394 (22%), Positives = 180/394 (45%), Gaps = 31/394 (7%)
Query: 4 FERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ-- 61
+E+ ++R +K+ M+ + ++ Q EEE RER ++ R+E +++EE + +
Sbjct: 420 WEQVEKMREEKK--MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 477
Query: 62 --VTDQVEVN-AQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---------RQK 109
+ +Q E Q +P+++ K E +++ E R +E RQ+
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 537
Query: 110 RLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
+++E ++ E + + D + Q + E +T E+E+K+ ++E+ EE
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWD---QEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 170 KSYQKND---WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSF 226
+ + + R+ EE +E +EK +E+EEK + Q ++EK+ + +E E +
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQE-EKMQEQEEKMWEQEEKMWEQEEK 653
Query: 227 MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR 286
M ++ E K + E K++ E + + +E E K+ + +
Sbjct: 654 MWEQQRLPEQKEKLWEH--EKMQEQEKMQEQ---EEKIWEQEKMEKKTQEQEKKTWDQEK 708
Query: 287 RRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE--EQRRKQEEADRKLREEE 344
R E E EK ++++E E EE +++EE+ + EEE EQ K E + K+ E++
Sbjct: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
Query: 345 EKRRLKEEI-ERRRAEAAEKRQKMPEDGLSDDKK 377
KE++ E + + EK + E ++K
Sbjct: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
Score = 81.3 bits (199), Expect = 2e-15
Identities = 95/390 (24%), Positives = 180/390 (46%), Gaps = 44/390 (11%)
Query: 1 MDDFERRRELRRQKREE---MRLEAERIAYQRND--DDEEEAARERRRRARQERL-RQKQ 54
M + ER RE ++ REE MR + E++ Q + + EE+ +++R ++E+L Q++
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 55 EEESLGQVTDQVE-VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQE 113
+E ++ +Q E + Q + +E K E +D+ E R +E++ +E
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565
Query: 114 ALERQ-KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSY 172
+E++ +E + D + R + E E +EE+ R++ +++E E +
Sbjct: 566 RMEKKTQEQEKKTWDQEEKM---REEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622
Query: 173 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKK- 231
++ W + EE +E +EK E+EEK E + +++ + KE E + +++K
Sbjct: 623 EEKMW-EQEEKMQEQEEKMWEQEEKMWEQE--EKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 232 GFTEVKSQNGEFMTHKLKHTEN-TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE 290
E K E M K + E T+ + R +E E + E EE+ R + E
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE-----EEMMREQEE 734
Query: 291 TESEEFEKLKQKQQEA----------------ALELEELKKKREERRKVLEEE-----EQ 329
E+ EK++++++E L E K+K E K+ E+E E+
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794
Query: 330 RRKQEEADRKLREEEEKRRLKEEIERRRAE 359
+ + +E K+R +EEK R +EE R + E
Sbjct: 795 KMRDQE--EKMRGQEEKMRGQEEKMRGQEE 822
Score = 77.0 bits (188), Expect = 4e-14
Identities = 75/340 (22%), Positives = 156/340 (45%), Gaps = 23/340 (6%)
Query: 38 ARERRRRARQERLRQKQEEESLGQVTDQVEVNA----QNSVPDEEAKTTTTNTQVEGDDE 93
A E +R R K+ + + ++T + + + +N++ +EE K Q ++
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ----EK 233
Query: 94 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS 153
E + K L+ LER K P + +L R + + E E ++++
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN----QIK 209
+ ++ + E E + ++ WR + ++++KE E+E+E ++ + E Q +
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Query: 210 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEA 269
+EK+ + +E E + M R++ + + K++ E R +E
Sbjct: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL----REK 409
Query: 270 EGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 329
E + E K E++ + R E + +E EK + Q+E +++E ++ RE +K+ EEEE
Sbjct: 410 EERMR-EQEKMWEQVEKMREEKKMQEQEKKTRDQEE---KMQEEERIREREKKMREEEET 465
Query: 330 RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 369
R+QEE + ++EE +EE E ++ E+++K+ E
Sbjct: 466 MREQEE--KMQKQEENMWE-QEEKEWQQQRLPEQKEKLWE 502
Score = 75.9 bits (185), Expect = 9e-14
Identities = 82/379 (21%), Positives = 171/379 (45%), Gaps = 14/379 (3%)
Query: 14 KREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
++E+M+ + E+I Q D+EE + ++ RQE++R+ +E+ + + +++ Q
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE--QEDQMWEQEEKMRDQEQK 559
Query: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSL 132
EE T Q + + R R R+K+++E E +E + + + +
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 133 PSRRMQNDTAENETTEKEEKSESRQER-YEIEETETVTKSYQKNDWRDAEENKKEDKEKE 191
+ + E + E+EEK ++E+ +E EE + + + E K +++EK
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 192 EEEEEKPKRGSIGENQIKDEKIKK-DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKH 250
+E+EEK E + ++++ K D+E E +S +R+K E + E +
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Query: 251 TENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES-EEFEKL-----KQKQQ 304
E + + K E ++ +RL E + + E E +E EK+ K + Q
Sbjct: 740 EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
Query: 305 EAALELEELKKK-REERRKVLEEE--EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 361
E + +E K + +EE+ + EE+ Q K + K+ +EEK +EE + +
Sbjct: 800 EEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ 859
Query: 362 EKRQKMPEDGLSDDKKPFK 380
E++ + E+ + ++ +
Sbjct: 860 EEKMREQEEKMRGQEEKMR 878
Score = 67.4 bits (163), Expect = 3e-11
Identities = 69/280 (24%), Positives = 137/280 (48%), Gaps = 30/280 (10%)
Query: 104 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT--AENETTE-----KEEKSESR 156
EE ++R +LE + TIT+ L + +Q AE+E +E KE K +
Sbjct: 200 EELTKERDALSLELYRN---TITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLE 256
Query: 157 QERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE-----EKPKRGSIGENQIKDE 211
+ ++ + + +T T Q+ WR EE ++++K+ ++EE E+ R G+ + ++E
Sbjct: 257 RAKFLLPQVQTNT--LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE 314
Query: 212 KI-KKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 270
K+ +++K +E+ K +++K E K +L+ E + +E +
Sbjct: 315 KMWRQEKRLREQEKELREQEKELREQK---------ELREQEEQMQEQ--EEKMWEQEEK 363
Query: 271 GAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR 330
Q E R EE R E + E E+ + Q+E E +E +++EER + E+ ++
Sbjct: 364 MREQEEKMWRQEE-RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
Query: 331 RKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 370
++ ++K++E+E+K R +EE + E+ +KM E+
Sbjct: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/211 (25%), Positives = 104/211 (49%), Gaps = 21/211 (9%)
Query: 183 NKKEDKEKEEEEEEKPKRG-SIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV----- 236
+KK D+ EE +E+ + N I +E++KK +E + +K ++
Sbjct: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251
Query: 237 --KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK---RLEELRRRRGET 291
K + +F+ +++ NT R + +E E + + K + E LR + G+
Sbjct: 252 KRKLERAKFLLPQVQ--TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 309
Query: 292 ESEEFEKLKQKQQ--EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 349
+E + +Q+++ E EL E +K+ E++++ E+EEQ ++QEE K+ E+EEK R
Sbjct: 310 REQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE---KMWEQEEKMRE 366
Query: 350 KEEIERRRAE---AAEKRQKMPEDGLSDDKK 377
+EE R+ E EK+ + E + D ++
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/293 (22%), Positives = 129/293 (44%), Gaps = 45/293 (15%)
Query: 108 QKRLQEALERQKEFDPTITDASLSLP--SRRMQNDTAENETTEKEEKSESRQERYEIEET 165
Q+ L R K+ D I + + S + +T NE E ++K+ QE+ + E+
Sbjct: 182 QRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNE--ELKKKNAELQEKLPLAES 239
Query: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKS 225
E + + N KE K K E K + N +++E ++++E +E+ K
Sbjct: 240 EK----------SEIQLNVKELKRKLERA--KFLLPQVQTNTLQEEMWRQEEELREQEKK 287
Query: 226 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 285
+++ + + E K++ E R KRL E
Sbjct: 288 IRKQEEKMWRQEERLRE-QEGKMREQEEKMWRQE-------------------KRLREQE 327
Query: 286 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLR 341
+ E E E E+ + ++QE ++ +E +K E+ K+ E+EE+ +QE E ++++R
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQE-EKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 342 EEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEER 394
E+E+K R +EE R ++R + E+ + + +K ++ K++E+
Sbjct: 387 EQEQKMRDQEE----RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Score = 50.4 bits (119), Expect = 4e-06
Identities = 54/261 (20%), Positives = 120/261 (45%), Gaps = 26/261 (9%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND----------DDEEEAARERRRRARQERLR 51
++ R +E + Q++EE E E +++ + + EE+ + + Q+RL
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 52 QKQE---EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQ 108
+++E E Q ++++ + E+ + T + + D+ E + RE R+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE--RE 719
Query: 109 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS-------ESRQERYE 161
K+++E E +E + + + + + + E + E+EEK E +++ +E
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 162 IEETETVTKSY-QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKI--KKDKE 218
E+ + K + Q+ RD EE + +EK +EEK RG + ++EK+ +++K
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK-MRGQEEKMWGQEEKMWGQEEKM 838
Query: 219 PKEEVKSFMDRKKGFTEVKSQ 239
+E K + +K +++ Q
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQ 859
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 94.7 bits (234), Expect = 2e-19
Identities = 92/390 (23%), Positives = 192/390 (49%), Gaps = 41/390 (10%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 346 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 405
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE-------RLARREERRQK--R 110
+ +++ + EE E +++ LE ++ +EE+RQ+ +
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 465
Query: 111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET--ETV 168
++E +RQ++ +A + +++ E + E+EEK ++E+ +E E
Sbjct: 466 IREQEKRQEQ------EAKMWRQEEKIREQ--EEKIREQEEKMWRQEEKIHEQEKIREEE 517
Query: 169 TKSYQKNDWRDAEENKKED-----KEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPK--- 220
+ Q+ WR E+ ++++ KEK E+EEK ++ E + E+ D+E K
Sbjct: 518 KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE--EKMWRQEEKMHDQEEKIRE 575
Query: 221 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 280
+E K + +K ++ Q + + K E + +E + Q E +
Sbjct: 576 QEEKVWRQEEK----IREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 631
Query: 281 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 340
EE RR+ E E+ +K+++ Q+E E EE+ +++EE K+ E+EE+ +QEE K+
Sbjct: 632 QEEKMRRQEEKIREQEKKIRE-QEEKIREQEEMMQEQEE--KMWEQEEKMCEQEE---KM 685
Query: 341 REEEEK-RRLKEEIERRRAEAAEKRQKMPE 369
+E+EEK RR +E++ + ++ +KM E
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Score = 87.8 bits (216), Expect = 2e-17
Identities = 82/353 (23%), Positives = 162/353 (45%), Gaps = 32/353 (9%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE--ESLGQVT 63
R +E + +++EEM E E + +E +E + R ++E + +K+E+ E ++
Sbjct: 392 REQEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 448
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+Q ++ Q EE K + E + + E R +E + + +E + RQ+E
Sbjct: 449 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE--K 506
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ +R + + + + E+ E +++ +I E E + ++ WR EE
Sbjct: 507 IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ-EEK 565
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 243
+ +EK E+EEK R ++EKI++ +E E + + ++ T+ + +
Sbjct: 566 MHDQEEKIREQEEKVWR--------QEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617
Query: 244 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 303
K+ E ++ E + E R +E + R E + E E++ Q+Q
Sbjct: 618 QEEKMCEQEEKMQ----------EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 667
Query: 304 QEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRRLKEE 352
+E E EE K E+ K+ E+EE+ R+QE E + +LR++EEK + +E
Sbjct: 668 EEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 80.1 bits (196), Expect = 5e-15
Identities = 84/324 (25%), Positives = 154/324 (47%), Gaps = 45/324 (13%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 272 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 317
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WR--------- 178
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR
Sbjct: 318 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 374
Query: 179 ----DAEENKKEDKEKEEEEEEKPKRGSIGENQI--KDEKIKKDKEPKEEVKSFMDRKKG 232
+ EE +E +EK E+EEK +R E + K+EK+++ +E E + M R++
Sbjct: 375 EKIQEQEEKIREQEEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 431
Query: 233 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGET 291
K + + K+ E + R + +E E + EA +E + R E
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 491
Query: 292 ESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEEQRRKQEEADR---KLREEEEK 346
+ E E+ +Q+E E E++++ KR+E+ ++ +EE+ R+QEE R K+ E+EEK
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551
Query: 347 -RRLKEEIERRRAEAAEKRQKMPE 369
R+ +E++ R+ + ++ +K+ E
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIRE 575
Score = 80.1 bits (196), Expect = 5e-15
Identities = 101/428 (23%), Positives = 195/428 (45%), Gaps = 63/428 (14%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E+++L E+E+ Q N + + + Q++L+ E + LG+
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 335
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK---RLQEALERQKE 120
V Q V + E N Q E E++ R+EE+ Q+ ++QE E+ +E
Sbjct: 336 QSVSAKLQAQVEENEL-WNRLNQQQE--------EKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 121 FDPTITDASLSLPSRRMQNDTAENETT---------EKEEKSESRQER-YEIEET--ETV 168
+ I + + RR + E E EKEEK ++E +E EE E
Sbjct: 387 QEEKIREQEEKM--RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIK----DEKIKKDKEPK-EEV 223
K +++ R+ EE ++E+++ E+E+ + + + + K +EKI++ +E +
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 224 KSFMDRKKGFTEVKSQNGEFM---THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 280
+ +++K E K Q E M K++ E + ++ E + E R
Sbjct: 505 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW-----------RQKEKIHEQEEKIR 553
Query: 281 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EA 336
+E + R E + + E+ ++Q+E EE K RE+ K+ E+EE+ R+QE E
Sbjct: 554 KQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE--KIREQEEKIREQEEKIREQEEMTQEQ 611
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
+ K+ E+EEK +EE + + E++ + E+ + + +K + KI E+ E
Sbjct: 612 EEKMGEQEEKMCEQEE----KMQEQEEKMRRQEEKIREQEKKI-----REQEEKIREQEE 662
Query: 397 FLNKSVQK 404
+ + +K
Sbjct: 663 MMQEQEEK 670
Score = 49.7 bits (117), Expect = 7e-06
Identities = 45/223 (20%), Positives = 104/223 (46%), Gaps = 54/223 (24%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
E+ ++R+Q+ + R E + D+EE RE+ + ++ + +++EE + + +
Sbjct: 547 EQEEKIRKQEEKMWRQEEKM-------HDQEEKIREQEEKVWRQEEKIREQEEKIREQEE 599
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
++ E+ + T + G+ E E++ +EE+ Q++ +E + RQ+E
Sbjct: 600 KIR---------EQEEMTQEQEEKMGEQE----EKMCEQEEKMQEQ-EEKMRRQEE---- 641
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
+E++ + R++ +I E E + + ++ W + EE
Sbjct: 642 ----------------------KIREQEKKIREQEEKIREQEEMMQEQEEKMW-EQEEKM 678
Query: 185 KEDKEKEEEEEEKPKR--GSIGENQIK----DEKIKKDKEPKE 221
E +EK +E+EEK +R + E +++ +EK+++ +E E
Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 94.4 bits (233), Expect = 2e-19
Identities = 83/374 (22%), Positives = 178/374 (47%), Gaps = 39/374 (10%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ EE E +++ LE + +E + + L+E + Q+
Sbjct: 345 WE--------------KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE 390
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
+ +R + + + +E++++ ++ +I E E + +K WR
Sbjct: 391 KIREQ--------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 442
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQIKD-EKIKKDKEPKEEVKSF--MDRKKGFTEV 236
E+ +++K +EEE+ ++ + E +I++ E+I + KE E + + K E
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEE 502
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
K + E K++ E R + +E + Q E + EE+ + + E E+
Sbjct: 503 KMHDQE---EKIREQEEKMWRQ--EEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQE 557
Query: 297 EKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERR 356
EK++++++ E +K RE+ K+ E++E+ R+QEE K+ E+EEK R +EE+ +
Sbjct: 558 EKMQEQEKMRRQE----EKIREQEEKIREQKEKIREQEE---KIWEQEEKIREQEEMMQE 610
Query: 357 RAEAA-EKRQKMPE 369
+ E E+ +KM E
Sbjct: 611 QEEKMWEQEEKMCE 624
Score = 83.6 bits (205), Expect = 4e-16
Identities = 90/358 (25%), Positives = 168/358 (46%), Gaps = 37/358 (10%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE--ESLGQVT 63
R +E + +++EEM E E + +E +E + R +E + +K+E+ E ++
Sbjct: 331 REQEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMH 387
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+Q ++ Q EE K + E + + E R +E + + ++ + RQ+E
Sbjct: 388 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE--K 445
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ +R + + + + E+ E +++ ++ E E + K +K WR EE
Sbjct: 446 IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV-WRQ-EEK 503
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQIKD--EKIKKDKEP---KEEVKSFMDRKKGFTEVKS 238
+ +EK E+EEK R E +I++ EKI++ +E +EE+ + K G E K
Sbjct: 504 MHDQEEKIREQEEKMWRQ---EEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 560
Query: 239 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 298
Q E K++ E + +E + Q E + EE + E + E E+
Sbjct: 561 QEQE----KMRRQEE---------KIREQEEKIREQKEKIREQEE-KIWEQEEKIREQEE 606
Query: 299 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRRLKEE 352
+ Q+Q+E E EE K E+ K+ E+EE+ R+QE E + +LR++EEK + +E
Sbjct: 607 MMQEQEEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 81.3 bits (199), Expect = 2e-15
Identities = 83/323 (25%), Positives = 152/323 (47%), Gaps = 44/323 (13%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WR--------- 178
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 313
Query: 179 ----DAEENKKEDKEKEEEEEEKPKRGSIGENQI--KDEKIKKDKEPKEEVKSFMDRKKG 232
+ EE +E +EK E+EEK +R E + K+EK+++ +E E + M R +
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRLEE 370
Query: 233 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGET 291
K + + K+ E + R + +E E + EA +E + R E
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 430
Query: 292 ESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEEQRRKQEEADR---KLREEEEK 346
+ E EK +Q+E E E++++ KR+E+ ++ +EE+ R+QEE R K+ E+E+
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKI 490
Query: 347 RRLKEEIERRRAEAAEKRQKMPE 369
R+ +E++ R+ + ++ +K+ E
Sbjct: 491 RKQEEKVWRQEEKMHDQEEKIRE 513
Score = 78.6 bits (192), Expect = 1e-14
Identities = 84/344 (24%), Positives = 165/344 (47%), Gaps = 48/344 (13%)
Query: 48 ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE-- 105
+ L++K E L Q++ A + + ++ + QVE E RL +++E
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQQEEK 301
Query: 106 --RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
R+++++QE E+ +E + I + + + + E EKEEK ++E +
Sbjct: 302 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM--MW 359
Query: 164 ETETVTKSYQKNDWRDAE-----ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKK-DK 217
E E + ++ W E E K ++EK E+EEK + ++EKI++ +K
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ---------EEEKIREQEK 410
Query: 218 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTK---EAEGAPQ 274
++E K + +K ++ Q K++ E R + K E + Q
Sbjct: 411 RQEQEAKMWRQEEK----IREQE-----EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ 461
Query: 275 VEAGKRLEELRRR----RGETESEEFEKLKQKQQEAALELEEL----KKKREERRKVLEE 326
E ++ E++R + R + + E EK+++++++ + E++ +K RE+ K+ +
Sbjct: 462 EEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQ 521
Query: 327 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMPE 369
EE+ R+QEE K+RE+EEK R +EE+ + + E E+ +KM E
Sbjct: 522 EEKIREQEE---KIREQEEKIREQEEMMQEQEEKMGEQEEKMQE 562
Score = 75.5 bits (184), Expect = 1e-13
Identities = 97/429 (22%), Positives = 203/429 (47%), Gaps = 60/429 (13%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E+++L E+E+ Q N + + + Q++L+ E + LG+
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 274
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK---RLQEALERQKE 120
V Q V + E N Q E E++ R+EE+ Q+ ++QE E+ +E
Sbjct: 275 QSVSAKLQAQVEENEL-WNRLNQQQE--------EKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 121 FDPTITDASLSLPSRRMQNDTAENETT---------EKEEKSESRQER-YEIEET--ETV 168
+ I + + RR + E E EKEEK +E +E EE E
Sbjct: 326 QEEKIREQEEKM--RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIK----DEKIKK-DKEPKEEV 223
K +++ R+ EE ++E+++ E+E+ + + + + K +EKI++ +K+ +
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443
Query: 224 KSFMDRKKGFTEVKSQNGEFM---THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 280
+ +++K E K Q E M K++ E + ++ E + E ++
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW-----------RQKEKMHEQEKIRK 492
Query: 281 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR-RKQE----E 335
EE R+ E ++ EK+++++++ + E+++++ E+ R E+E++ R+QE E
Sbjct: 493 QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR----EQEEKIREQEEMMQE 548
Query: 336 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 395
+ K+ E+EEK + +E++ R+ + E+ +K+ E ++ K + + KI E+
Sbjct: 549 QEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEE---KIREQE 605
Query: 396 EFLNKSVQK 404
E + + +K
Sbjct: 606 EMMQEQEEK 614
Score = 43.5 bits (101), Expect = 5e-04
Identities = 38/198 (19%), Positives = 100/198 (50%), Gaps = 26/198 (13%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ ++ E ++ E+M + E+I + +E+ +E + R ++E++R+++E +
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKI----REQEEKMWRQEEKIREQEEKIREQEE-----K 538
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALERQ 118
+ +Q E+ + ++E K E +++ E++ R+EE+ ++++++E E+
Sbjct: 539 IREQEEM-----MQEQEEK------MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI 587
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+E + I + + + E + E+EEK ++E+ ++E E + ++ W
Sbjct: 588 REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK--MQEQEEKMRRQEEKMW- 644
Query: 179 DAEENKKEDKEKEEEEEE 196
+ E ++ +EK +E +E
Sbjct: 645 EQEVRLRQQEEKMQEHQE 662
Score = 29.6 bits (65), Expect = 7.3
Identities = 13/67 (19%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLG 60
+ + E+ +++ E+M + E++ Q ++EE R + + ++ +R +Q+EE +
Sbjct: 599 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 658
Query: 61 QVTDQVE 67
+ + +E
Sbjct: 659 EHQEHLE 665
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 93.2 bits (230), Expect = 5e-19
Identities = 88/370 (23%), Positives = 175/370 (47%), Gaps = 55/370 (14%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRAR-QERLRQKQEEESLG 60
+ R+ E+ +K E+MR + E + ++EE RE + QE++R+++E+
Sbjct: 363 EKMRRQEEMMWEKEEKMRRQEEMMW------EKEEKIRELEEKMHEQEKIREQEEKRQ-- 414
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ ++ Q ++EAK ++ +E R +E++ R +E + Q++
Sbjct: 415 ---EEEKIREQEKRQEQEAKMWRQEEKIREQEEKI------REQEKKMWRQEEKIHEQEK 465
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ +R + + + + E+ E +++ ++ E E + ++ WR
Sbjct: 466 ---------IREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ- 515
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 240
EE +E +EK E+EEK R ++EKI++ +E E + +++K + E K Q
Sbjct: 516 EEKIREQEEKIREQEEKMWR--------QEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567
Query: 241 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 300
E K+ E + +E + Q E + EE R+ + E ++ EK++
Sbjct: 568 QE---DKMWRQEE---------KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR 615
Query: 301 QKQQEAALELEELKKKREERRKVLEEEEQRRKQE----EADRKLREEEEKRRLKEEIERR 356
+ Q+E E EE K RE+ K+ E+EE ++QE E + K+ E+EEK + +EE R
Sbjct: 616 E-QEEKIQEQEE--KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWR 672
Query: 357 RAEAAEKRQK 366
+ E +++K
Sbjct: 673 QEEKIREQEK 682
Score = 92.8 bits (229), Expect = 7e-19
Identities = 97/372 (26%), Positives = 173/372 (46%), Gaps = 36/372 (9%)
Query: 4 FERRRELRRQK-----REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58
+E+ ++RRQ+ +EE E E +++ E+E R+ + R++ RQ+QE +
Sbjct: 373 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
Q + + ++E K ++ +E + R EE+RQ+ QE + RQ
Sbjct: 433 WRQ---------EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE--QEEMWRQ 481
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+E + R+ + + E K+E+ RQE +I E E + ++ WR
Sbjct: 482 EEKIHEQEEIW-----RQKEKMHEQEEKIRKQEEKVWRQEE-KIREQEEKIREQEEKMWR 535
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKS 238
EE +E +E EEE+ ++ I E + + E+ +DK ++E K +K V
Sbjct: 536 Q-EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ--EDKMWRQEEKIREQEEK----VWR 588
Query: 239 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 298
Q + + K E + +E + Q E + EE R + E E+ EK
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Query: 299 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRA 358
+ + Q+E E EE K +E+ + +EE+ R+QE +K+RE+EEK R +EE+ + +
Sbjct: 649 MGE-QEEKMCEQEE--KMQEQEETMWRQEEKIREQE---KKIREQEEKIREQEEMMQEQE 702
Query: 359 EAA-EKRQKMPE 369
E E+ +KM E
Sbjct: 703 EKMWEQEEKMCE 714
Score = 86.7 bits (213), Expect = 5e-17
Identities = 81/383 (21%), Positives = 175/383 (45%), Gaps = 39/383 (10%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIA-YQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
+++ E L +Q+ E+M + E+I ++ ++EE RE+ + R++ + +++EE +
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
+ +++ + EE E +++ E + +E + + L+E + Q+
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
+ +R + + + +E++++ ++ +I E E + +K WR
Sbjct: 405 KIREQ--------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 456
Query: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQIKD-EKIKKDKEPKEEVKSFMDRKKGFTEVKS 238
E+ +++K +EEE+ ++ + E +I + E+I + KE E + + +++ +
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQE 516
Query: 239 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 298
+ K++ E R Q E + EE+ R + +E
Sbjct: 517 EKIREQEEKIREQEEKMWR----------------QEEKIREQEEMWREEEKMHEQEKIW 560
Query: 299 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE----IE 354
++K+QE +E K R+E K+ E+EE+ +QEE K+RE+EEKR+ +EE E
Sbjct: 561 EEEKRQE-----QEDKMWRQEE-KIREQEEKVWRQEE---KIREQEEKRQEQEEKMWKQE 611
Query: 355 RRRAEAAEKRQKMPEDGLSDDKK 377
+ E EK Q+ E ++K
Sbjct: 612 EKIREQEEKIQEQEEKIREQEEK 634
Score = 77.8 bits (190), Expect = 2e-14
Identities = 85/335 (25%), Positives = 154/335 (45%), Gaps = 53/335 (15%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 211 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 256
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WR--------- 178
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR
Sbjct: 257 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 313
Query: 179 ----DAEENKKEDKEKEEEEEEKPKRGS--IGENQIK-----------DEKIKKDKEPKE 221
+ EE +E +EK E+EEK +R + E + K +EK+++ +E
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 373
Query: 222 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVEAGKR 280
E + M R++ K + + K+ E + R + +E E + EA
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 433
Query: 281 LEELRRRRGETESEEFEKLKQKQQEAALELEELK--KKREERRKVLEEEEQRRKQEEADR 338
+E + R E + E EK +Q+E E E+++ +KR+E+ ++ +EE+ +QEE R
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 339 ---KLREEEEK-RRLKEEIERRRAEAAEKRQKMPE 369
K+ E+EEK R+ +E++ R+ + E+ +K+ E
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Score = 49.7 bits (117), Expect = 7e-06
Identities = 43/202 (21%), Positives = 94/202 (46%), Gaps = 46/202 (22%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQ---RNDDDEEEAARERRRRARQERLRQKQEEES 58
D R+ E R++ E++ + E+I Q R + +E+ +E + R ++E++++++E
Sbjct: 570 DKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE--- 626
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
++ Q E+ + T + G+ E E++ +EE+ Q++ +E + RQ
Sbjct: 627 --------KIREQEEKIREQEEMTQEQEEKMGEQE----EKMCEQEEKMQEQ-EETMWRQ 673
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+E +E++ + R++ +I E E + + ++ W
Sbjct: 674 EE--------------------------KIREQEKKIREQEEKIREQEEMMQEQEEKMW- 706
Query: 179 DAEENKKEDKEKEEEEEEKPKR 200
+ EE E +EK +E+EEK +R
Sbjct: 707 EQEEKMCEQEEKMQEQEEKMRR 728
Score = 36.2 bits (82), Expect = 0.078
Identities = 29/120 (24%), Positives = 60/120 (50%), Gaps = 8/120 (6%)
Query: 6 RRRELRRQKREE-MRLEAERIAYQR--NDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
R +E + Q++EE +R + E+I Q + EE+ + + QE Q+QEE Q
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQ- 673
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEALERQKE 120
++ + + ++E K ++ +E + E++ +EE+ Q++ +E + RQ+E
Sbjct: 674 -EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ-EEKMRRQEE 731
Score = 32.7 bits (73), Expect = 0.86
Identities = 21/122 (17%), Positives = 61/122 (50%), Gaps = 8/122 (6%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ + E+ +++ E+M + E++ Q E+E R+ +E+ ++ +E+E +
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALERQ 118
+++ + + ++E K +++ + E++ R+EE+ ++ RL++ E+
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEKMWEQEVRLRQQEEKM 747
Query: 119 KE 120
+E
Sbjct: 748 QE 749
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 93.2 bits (230), Expect = 5e-19
Identities = 85/371 (22%), Positives = 183/371 (49%), Gaps = 27/371 (7%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE----ESLG 60
E+ ++R Q+ + E + + ++E RE+ + R++ + +++E E G
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QV +Q + V ++E + QV + + RE+ Q R QE R++E
Sbjct: 123 QVREQ-----EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 177
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ + + + Q E + E+EE+ ++E+ + +E + Q+ R
Sbjct: 178 GQ--VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM---GEQEEQMRKQ 232
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIK--DEKIKKDKEPKEEVKSFMDRKKGFTEVKS 238
EE E +E+ +++EE+ ++ E Q++ +E++++ +E E + M ++K TE +
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQ---EEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Query: 239 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 298
Q GE +++ E R + +E + + GK+ E++ ++ + ++ +
Sbjct: 290 QTGE-QEEQMREQEEQM-REQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQM 347
Query: 299 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRA 358
KQ++Q E E+++K+ E+ RK +EEQ RKQEE RK +EE+ R+ +E++ ++
Sbjct: 348 WKQEEQMGEQE-EQMQKQEEQVRK---QEEQMRKQEEQMRK--QEEQMRKQEEQMGEQKE 401
Query: 359 EAAEKRQKMPE 369
+ E++++M E
Sbjct: 402 QMGEQKEQMRE 412
Score = 77.8 bits (190), Expect = 2e-14
Identities = 75/360 (20%), Positives = 170/360 (47%), Gaps = 21/360 (5%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV-EVNAQN 72
K + +LE ++I + E+ + R + Q R ++ Q E GQV +Q +V Q
Sbjct: 35 KELKRKLETDKIPLPQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVREQEGQVREQE 93
Query: 73 S-VPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLS 131
V ++E + QV + + RE+ Q R QE R++E + +
Sbjct: 94 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV- 152
Query: 132 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQ-KNDWRDAEENKKEDKEK 190
R + E E +E++ + R++ ++ E E + + + ++ + ++E++
Sbjct: 153 ---REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMG 209
Query: 191 EEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKH 250
E+EE+ + + +GE ++E+++K +E E + + +++ + + + +++
Sbjct: 210 EQEEQMQKQEEQMGE---QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE 266
Query: 251 TENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL 310
E + ++ E Q G++ E++R + E + E E+ ++Q+E E
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQT--GEQEEQMREQ--EEQMREQEEQMREQEEQMREQ 322
Query: 311 EELKKKREERRKVLEEEEQRRKQEE----ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
EE K+EE+ + E++EQ +Q+E + ++ E+EE+ + +EE R++ E K+++
Sbjct: 323 EEQMGKQEEQ--MWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE 380
Score = 73.6 bits (179), Expect = 4e-13
Identities = 77/353 (21%), Positives = 160/353 (45%), Gaps = 29/353 (8%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEE----ESLG 60
E+ ++R Q+ + E + + ++E RE+ + R++ + +++E E G
Sbjct: 84 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 143
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
QV +Q + V ++E + QV + + RE+ Q R QE ++E
Sbjct: 144 QVREQ-----EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQE 198
Query: 121 FDPTITDASLSLPSRRMQNDTAE----NETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ + +MQ + E K+E+ QE ++ E V K Q+
Sbjct: 199 GQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK--QEEQ 256
Query: 177 WRDAEENKKEDKEKEEEEEE---KPKRGSIGENQI--KDEKIKKDKEP-KEEVKSFMDRK 230
R EE +E +E+ E+EE K K + E Q ++E++++ +E +E+ + +++
Sbjct: 257 MRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE 316
Query: 231 KGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE-----AGKRLEELR 285
+ E + Q G+ + E + + + + E Q++ K+ E++R
Sbjct: 317 EQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR 376
Query: 286 RRRGETESEEFEKLKQKQQ--EAALELEELKKK-REERRKVLEEEEQRRKQEE 335
++ + +E + KQ++Q E ++ E K++ RE+ ++ E++EQ RKQEE
Sbjct: 377 KQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 72.4 bits (176), Expect = 1e-12
Identities = 80/403 (19%), Positives = 181/403 (44%), Gaps = 49/403 (12%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +EE++L E E+ Q + +E +R+ +++ QE GQV
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLH-------IKELKRKLETDKIPLPQE----GQVR 55
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+Q + V ++E + QV + + RE+ Q R QE R++E
Sbjct: 56 EQ-----EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 110
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
R + E E +E++ + R++ ++ E E + ++ +
Sbjct: 111 -----------REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE------QEGQVR 153
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKG-FTEVKSQNGE 242
++E + +E+E + + + G + E ++ ++++ + E + M ++G E + Q GE
Sbjct: 154 EQEGQVREQEGQVREQEGQVRE---QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGE 210
Query: 243 FMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK 302
K E G + K+ E + G++ E+++++ + + +E + KQ+
Sbjct: 211 QEEQMQKQEEQM----GEQEEQMRKQEE-----QMGEQEEQVQKQEEQVQKQEEQMRKQE 261
Query: 303 QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK-RRLKEEIERRRAEAA 361
+Q E E+++++ E+ K E+ EQ + E + ++RE+EE+ R +E++ + +
Sbjct: 262 EQMREQE-EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320
Query: 362 EKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
E+ ++M + ++ + + K K EE+ + +QK
Sbjct: 321 EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQK 363
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/231 (21%), Positives = 109/231 (47%), Gaps = 16/231 (6%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ +++ E ++ E+MR + E++ Q EE+ ++ + +QE +KQEE Q
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQ-----EEQVQKQEEQVQKQEEQMRKQEE----Q 263
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQEALERQKE 120
+ +Q E + + K T + G+ E E+ + RE+ Q R QE R++E
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ + +M + E K+E+ QE ++ E V K ++ ++
Sbjct: 324 EQMGKQEEQMWEQKEQMWE---QKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE 380
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKK 231
+ K+E++ +++EE+ ++ +GE + E++++ +E E K M +++
Sbjct: 381 QMRKQEEQMRKQEEQMGEQKEQMGEQK---EQMREQEEQMGEQKEQMRKQE 428
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/195 (20%), Positives = 88/195 (45%), Gaps = 20/195 (10%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ ++ E R++ E+MR + E++ Q+ ++EE E+ + R++ + +++EE + +
Sbjct: 255 EQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE 314
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+Q+ + EE E ++ E +E + ++ +E + +Q+E
Sbjct: 315 QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE- 373
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+M+ + E K+E+ +QE E+ E + + QK R+ E
Sbjct: 374 --------------QMRK---QEEQMRKQEEQMRKQEEQMGEQKEQMGE--QKEQMREQE 414
Query: 182 ENKKEDKEKEEEEEE 196
E E KE+ ++EE
Sbjct: 415 EQMGEQKEQMRKQEE 429
Score = 57.4 bits (137), Expect = 3e-08
Identities = 50/223 (22%), Positives = 108/223 (48%), Gaps = 14/223 (6%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E+ ++R+Q+ E+M + E++ Q +EE R++ + R++ + +++EE + +
Sbjct: 224 EQEEQMRKQE-EQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
+Q E Q +E+ + + E +++ E R +E + + +E + QKE
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMR-EQEEQMREQEEQMREQEEQMGKQEEQMWEQKE--- 338
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
+ + + + Q E E +K+E+ +QE ++ E + K Q+ R EE
Sbjct: 339 QMWEQKEQMWKQEEQMGEQE-EQMQKQEEQVRKQEEQMRKQEEQMRK--QEEQMRKQEEQ 395
Query: 184 KKEDKEK--EEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVK 224
E KE+ E++E+ + + +GE + E+++K +E E K
Sbjct: 396 MGEQKEQMGEQKEQMREQEEQMGEQK---EQMRKQEEHMGEQK 435
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 92.4 bits (228), Expect = 9e-19
Identities = 83/346 (23%), Positives = 152/346 (43%), Gaps = 44/346 (12%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+ R+E+ +++RE R E ER +R + E E RER + +ER R++ + + D
Sbjct: 300 KERQEIEKERRERER-ERERERERREREREREREREREKEKERERERERDRDRDRTKERD 358
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ ++ D E + + +++ ER RE R++ + ER++E +
Sbjct: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE-- 416
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE----ETETVTKSYQKNDWRDA 180
R + + +++ ++EE E ER ++E E E + KN W
Sbjct: 417 --------REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN-WEIR 467
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 240
E K + EKE E EE+ +R E K+ K KE ++ + D + + K
Sbjct: 468 ERKKTREYEKEAEREEERRR----------EMAKEAKRLKEFLEDYDDDR---DDPKYYR 514
Query: 241 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR-RGETESEEFEKL 299
G + +L+ E EA+ + + LEE+R+R E + +L
Sbjct: 515 GSALQKRLRDREKEM------------EADERDRKREKEELEEIRQRLLAEGHPDPDAEL 562
Query: 300 KQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 345
++ +QEA + K+ E + EEEE++ K+E+ + + EEEE
Sbjct: 563 QRMEQEAERRRQPQIKQEPESEE--EEEEKQEKEEKREEPMEEEEE 606
Score = 69.3 bits (168), Expect = 8e-12
Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 22/246 (8%)
Query: 149 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 208
+EEK + +ER EIE+ E + ++ R+ E ++E + + E E+EK + ++
Sbjct: 292 EEEKGKKEKERQEIEK-ERRERERERERERERREREREREREREREKEKERERERERDRD 350
Query: 209 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 268
+D ++D++ E DR++ K ++ SR R +E
Sbjct: 351 RDRTKERDRDRDRERDRDRDRERSSDRNKDRSR--------------SREKSRDRERERE 396
Query: 269 AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE- 327
E + E + E R R E E E E+ K K+++ + E+ ++R+ RK+ E+E
Sbjct: 397 RERERERERERERERERERERERERER-EREKDKKRDREEDEEDAYERRKLERKLREKEA 455
Query: 328 ---EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 384
E+ + E +RK E EK +EE RR KR K + DD+ K +
Sbjct: 456 AYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYY-- 513
Query: 385 KGSSLK 390
+GS+L+
Sbjct: 514 RGSALQ 519
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 89.0 bits (219), Expect = 1e-17
Identities = 98/388 (25%), Positives = 183/388 (47%), Gaps = 46/388 (11%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E+++L E+E+ Q N + + + Q++L+ E + LG+
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 262
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER---RQKRLQEALERQKE 120
V Q V + E N Q E E++ R+EE+ R++++QE E+ +E
Sbjct: 263 QSVSAKLQAQVEENEL-WNRLNQQQE--------EKMWRQEEKIQEREEKIQEQEEKIRE 313
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEK-----------------SESRQERYEIE 163
+ + + + + E EKEEK E RQE +I
Sbjct: 314 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 373
Query: 164 ETETVTKSYQKNDWRDAEE-NKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEE 222
E E + K WR E+ ++E+K +E+EE + + +GE ++EK+ + +E +E
Sbjct: 374 EQEKRQEQEAKM-WRQEEKIREQEEKIREQEEMMQEQEEKMGE---QEEKMWEQEEEMQE 429
Query: 223 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE 282
+ M R++ +++ Q + + K E + +E + Q EA + +
Sbjct: 430 QEEKMRRQE--EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ-EAKMQEQ 486
Query: 283 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLRE 342
E + RR E + E EK ++Q+E E EE+ +++EE K+ E+EE+ +QEE K++E
Sbjct: 487 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE--KMWEQEEKMCEQEE---KMQE 541
Query: 343 EEEK-RRLKEEIERRRAEAAEKRQKMPE 369
+EEK RR +E++ + ++ +KM E
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 87.8 bits (216), Expect = 2e-17
Identities = 86/308 (27%), Positives = 149/308 (48%), Gaps = 37/308 (12%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER K L
Sbjct: 199 RNTITDEELKEKNAKLQ----EKLQLVESEKSEIQLNVKELKRKLERAK----------L 244
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND---WRDAEENKKED 187
LP +++Q AE + KE +S S + + ++EE E + Q+ + WR EE +E
Sbjct: 245 LLPQQQLQ---AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-EEKIQER 300
Query: 188 KEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 247
+EK +E+EEK + ++EK+++ +E E + M R++ K + + K
Sbjct: 301 EEKIQEQEEKIRE--------QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 352
Query: 248 LKHTENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 306
+ E + R + +E E + EA +E + R E + E E++ Q+Q+E
Sbjct: 353 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 307 ALELEELKKKREERRKVLEEEEQRRKQEEA----DRKLREEEEKRRLKEEIERRRAE-AA 361
E EE K E+ ++ E+EE+ R+QEE ++K+RE+EEK R +EE+ + + E
Sbjct: 413 MGEQEE--KMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG 470
Query: 362 EKRQKMPE 369
E+ KM E
Sbjct: 471 EQEGKMCE 478
Score = 75.1 bits (183), Expect = 2e-13
Identities = 80/354 (22%), Positives = 160/354 (45%), Gaps = 63/354 (17%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRN--DDDEEEAARERRRRARQERLRQKQEEES 58
+++ E L +Q+ E+M + E+I + + EE+ + + RQE + ++EE+
Sbjct: 273 VEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
Q +++ + + + E K E +++ E++ +E+R+++ + + RQ
Sbjct: 333 RRQ--EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ--EAKMWRQ 388
Query: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
+E + E+EEK ++E ++E E ++ W
Sbjct: 389 EE------------------------KIREQEEKIREQEEM--MQEQEEKMGEQEEKMW- 421
Query: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKS 238
+ EE +E +EK +EEK + +++KI++ +E E + M ++ ++
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIRE--------QEKKIREQEEKIREQEEMMQEQE--EKMGE 471
Query: 239 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 298
Q G+ + K E + E + E R +E + R E + E E+
Sbjct: 472 QEGKMCEQEAKMQE---------------QEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 299 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 352
+ Q+Q+E E EE K E+ K+ E+EE+ R+QEE K+RE+E + R +EE
Sbjct: 517 MMQEQEEKMWEQEE--KMCEQEEKMQEQEEKMRRQEE---KMREQEVRLRQQEE 565
Score = 33.5 bits (75), Expect = 0.50
Identities = 18/116 (15%), Positives = 52/116 (44%), Gaps = 1/116 (0%)
Query: 2 DDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
+ + E+ +++ E+M E + + ++EE R + + R++ + +++EE +
Sbjct: 453 EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALE 116
+ + ++ + EE E +++ E R +E R ++ +E ++
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/227 (29%), Positives = 114/227 (50%), Gaps = 44/227 (19%)
Query: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 202
++E E+E + E+R+E + E+E R E ++E +++E E+E K +RG
Sbjct: 35 QSEIREREREIETRKEGKKERESE-----------RKKERREREKRKREREKERKRERG- 82
Query: 203 IGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 262
+K KK + KEE +RKK E +++ GE + K + + GR
Sbjct: 83 --------KKEKKGERKKEE----RERKKRRREKENKEGEEKEKRKKKEK----KERGRT 126
Query: 263 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK 322
S + KE R R+ E + EE ++ ++K++E E E ++K+ ER++
Sbjct: 127 SKEGKE----------------RERKEERKREERKERERKKEEREKERERKERKKRERKQ 170
Query: 323 VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE 369
V E+EE+R+++E +RK RE K R KE + R E ++R+K E
Sbjct: 171 VGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEE 217
Score = 67.4 bits (163), Expect = 3e-11
Identities = 60/245 (24%), Positives = 113/245 (46%), Gaps = 36/245 (14%)
Query: 113 EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSY 172
E ER++E + T + S R + + E E ++E + E ++ER + E+ K
Sbjct: 37 EIREREREIE-TRKEGKKERESER-KKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 173 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKG 232
++ R E+ KE +EKE+ +K ++ G + ++ ++ +E K E + +RKK
Sbjct: 95 RERKKRRREKENKEGEEKEKR--KKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 233 FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETE 292
E K E + R V KE E R E+ R+ R + E
Sbjct: 153 ERE-------------KERERKERKKRERKQVGEKEEE---------RKEKERKERKKRE 190
Query: 293 SEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 352
E+ K+++ +K+R ER+K +++E+R+K+ + DR+ E++R +E
Sbjct: 191 RNRKERKKERE----------RKERRERKKERKKKEERKKERQKDRQTNWREKERGKRER 240
Query: 353 IERRR 357
ER++
Sbjct: 241 KERKK 245
Score = 66.2 bits (160), Expect = 7e-11
Identities = 43/196 (21%), Positives = 100/196 (51%), Gaps = 12/196 (6%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER E ++++RE + + ER ++ + ++E ER++ R+ + R++++E G+ +
Sbjct: 54 ERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKE 113
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR------REERRQKRLQEALERQ 118
+ + + E +T+ + E +E ER R RE+ R+++ ++ ER+
Sbjct: 114 KRKKKEKK----ERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERK 169
Query: 119 K--EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
+ E + + +R +N + E++E+ E ++ER + EE + + ++ +
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTN 229
Query: 177 WRDAEENKKEDKEKEE 192
WR+ E K+E KE+++
Sbjct: 230 WREKERGKRERKERKK 245
Score = 64.7 bits (156), Expect = 2e-10
Identities = 53/217 (24%), Positives = 94/217 (43%), Gaps = 31/217 (14%)
Query: 15 REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSV 74
+ E+R I ++ E E+ R++ RR R++R R++++E
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKER----------------- 77
Query: 75 PDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 134
K + +G+ + ER RR E+ K +E +R+K+ S
Sbjct: 78 -----KRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKE 132
Query: 135 RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 194
R + + E E+E K E R E E K +K + + E ++E KEKE +E
Sbjct: 133 RERKEERKREERKERERKKEER-------EKERERKERKKRERKQVGEKEEERKEKERKE 185
Query: 195 EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKK 231
+K +R + + K+ + K+ +E K+E K +RKK
Sbjct: 186 RKKRERNR--KERKKERERKERRERKKERKKKEERKK 220
Score = 63.5 bits (153), Expect = 5e-10
Identities = 50/234 (21%), Positives = 107/234 (45%), Gaps = 30/234 (12%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQ---ERLRQKQEEESLGQVTDQ 65
E+R ++RE +E + + + + ++ RER +R R+ ER R++ ++E G+
Sbjct: 37 EIRERERE---IETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGE---- 89
Query: 66 VEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTI 125
+ E K EG++ +E+R++K +E KE
Sbjct: 90 -----RKKEERERKKRRREKENKEGEE----------KEKRKKKEKKERGRTSKEGKERE 134
Query: 126 TDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK 185
R+ + E E+E K ++ER ++ E E K ++ + + E N+K
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK 194
Query: 186 EDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 239
E K++ E +E + ++ + + K E+ KK+++ K+ ++ ++++G E K +
Sbjct: 195 ERKKERERKERRERK----KERKKKEERKKERQ-KDRQTNWREKERGKRERKER 243
Score = 62.4 bits (150), Expect = 1e-09
Identities = 48/175 (27%), Positives = 77/175 (44%), Gaps = 10/175 (5%)
Query: 240 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE----------ELRRRRG 289
N E H ++PG ++ + +E E + E K E E R+R
Sbjct: 14 NTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKRER 73
Query: 290 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 349
E E + K+K+ E E E KK+R E+ EE+++RK++E + R +E +
Sbjct: 74 EKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 350 KEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
+ + ER+R E E+ +K E ++K K K K EER E K +K
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKK 188
Score = 57.4 bits (137), Expect = 3e-08
Identities = 39/153 (25%), Positives = 74/153 (48%), Gaps = 9/153 (5%)
Query: 234 TEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES 293
+E++ + E T K E R R + ++ E + + + +E + R + E
Sbjct: 36 SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER 95
Query: 294 EEFEKLKQKQQEAALELEELKKKREERR-------KVLEEEEQRRKQE--EADRKLREEE 344
E ++ ++K+ + E E+ KKK ++ R K E +E+R+++E E +RK E E
Sbjct: 96 ERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEERE 155
Query: 345 EKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 377
++R KE +R R + EK ++ E + KK
Sbjct: 156 KERERKERKKRERKQVGEKEEERKEKERKERKK 188
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 85.5 bits (210), Expect = 1e-16
Identities = 96/422 (22%), Positives = 199/422 (47%), Gaps = 39/422 (9%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
DD + E + + ++ + E +A + +++EEE + +++ Q+ +Q ++ +
Sbjct: 56 DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ D+ + + + P E + + + DD+ L + A+ + ++ + + E +
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGS-----DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDE-- 168
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
D S + R N + E+ E +E +SR+ + + ++ + N+ DA
Sbjct: 169 -----DNSKKIKERSRINSSGESGD-ESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDAS 222
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
K +K+ E++E+ ++ + + K++K KE KEE+++ KK ++ K
Sbjct: 223 FKIKTVAQKKAEKKERERK----KRDEEKAKLRKLKE-KEELET---GKKDQSKQKESQR 274
Query: 242 EFM--THKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKL 299
+F T K K T +T P +T A E K+ ++ ++++GE E +E EK
Sbjct: 275 KFEEETVKSKVTVDTGVIPASEEKAETPTA-AEDDNEGDKKKKDKKKKKGEKEEKEKEKK 333
Query: 300 KQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADR--KLREEEEKRRLKEEIERRR 357
K + ++E K L+EEE+R+K+EE +R +L E E KR+ +E +E+ +
Sbjct: 334 KGPSKATVKAMQEALAK-------LKEEEERQKREEEERIKRLEELEAKRKEEERLEQEK 386
Query: 358 AEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIV 417
E ++++K ++ L KK K T S + RAE K +Q + GV+ + ++
Sbjct: 387 RERKKQKEKERKERL---KKEGKLLTK--SQREARARAEATLKLLQ-AQGVEVPSKDSLP 440
Query: 418 SK 419
K
Sbjct: 441 KK 442
Score = 65.5 bits (158), Expect = 1e-10
Identities = 82/383 (21%), Positives = 165/383 (43%), Gaps = 41/383 (10%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
++E R+KR+E + + ++ ++EE ++ +++Q+ ++K EEE+ V +V
Sbjct: 235 KKERERKKRDEEKAKLRKLK------EKEELETGKKDQSKQKESQRKFEEET---VKSKV 285
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
V+ +P E K T T E D+E +++++++K +E E++K+ P+
Sbjct: 286 TVDT-GVIPASEEKAETP-TAAEDDNEGD----KKKKDKKKKKGEKEEKEKEKKKGPSKA 339
Query: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186
+ MQ A+ + E+ +K E + +EE E K ++ + E K++
Sbjct: 340 TV------KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK 393
Query: 187 DKEKEEEEEEKPKRGSIGENQIKDE-----KIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+KE++E +++ K + + + + K+ + + + K + +K+ E K +
Sbjct: 394 EKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK 453
Query: 242 EFMTHKLKHTENTFSRPGG----RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 297
+ K + V KE E P VE + + + E+ +
Sbjct: 454 IPQQLESKEVSESMELCAAVEVMEQGVPEKE-ETPPPVEPEEEEDTEDAGLDDWEAMASD 512
Query: 298 KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 357
+ +K + + +E + EE + EEEE +EE EEEE E +
Sbjct: 513 EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEE------EEEEGESEGSEGD--- 563
Query: 358 AEAAEKRQKMPEDGLSDDKKPFK 380
E EK + G + DKKP K
Sbjct: 564 -EEDEKVSDEKDSGKTLDKKPSK 585
Score = 56.6 bits (135), Expect = 6e-08
Identities = 60/298 (20%), Positives = 126/298 (42%), Gaps = 23/298 (7%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
+ E RQKREE + +EE +E+R R +Q+ +K+ + G++ +
Sbjct: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKS 411
Query: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARR----EERRQKRLQEALERQKEFD 122
+ A+ A+ T Q +G E + L ++ E++++K++ + LE ++ +
Sbjct: 412 QREAR-----ARAEATLKLLQAQGV-EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSE 465
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
A++ + + + E EE+ ++ + E + +K +
Sbjct: 466 SMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHI 525
Query: 183 NKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 242
KE+ E+EEEEEE+ + E + ++E + E EE + D K + + +
Sbjct: 526 EVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSK 585
Query: 243 FMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 300
M+ ++ S D + E +A +R+E +RR +++ EKL+
Sbjct: 586 EMSSDSEYD-----------SDDDRTKEERAYDKAKRRIE--KRRLEHSKNVNTEKLR 630
Score = 46.6 bits (109), Expect = 6e-05
Identities = 77/316 (24%), Positives = 127/316 (40%), Gaps = 80/316 (25%)
Query: 173 QKNDWRDAEENKKED-------KEKEE-----------------------EEE----EKP 198
QK+ + +E KK+D KE EE EEE +K
Sbjct: 38 QKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKK 97
Query: 199 KRGSIGENQI-----------KDEKIKKDKEPKEEVKSFMDRKKGFTEV------KSQNG 241
K+G G+ Q KD K KK +PK E+ S D F ++ K+Q
Sbjct: 98 KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKS 157
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTK-----EAEGAPQVEAGKRLEELRR-----RRGET 291
+ E+ + R+ +++ E++ Q G++ + + G
Sbjct: 158 NKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNE 217
Query: 292 ESEEFEKLKQKQQEAALELEELKKKREER----RKVLEEEE------QRRKQEEADRKLR 341
+ + K+K Q+ A + E +KKR+E RK+ E+EE + KQ+E+ RK
Sbjct: 218 DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKF- 276
Query: 342 EEEEKRRLKEEIERRRAEAAEKRQKMP---EDGLSDDKKPFKCFTPKGSSLKIEERAEFL 398
EEE + K ++ A+E++ + P ED DKK KG EE+ +
Sbjct: 277 -EEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK---EEKEKEK 332
Query: 399 NKSVQKSSGVKSTHQA 414
K K++ VK+ +A
Sbjct: 333 KKGPSKAT-VKAMQEA 347
Score = 37.0 bits (84), Expect = 0.046
Identities = 63/310 (20%), Positives = 115/310 (37%), Gaps = 51/310 (16%)
Query: 181 EENKKEDKEKEEEE-----EEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTE 235
++NK ED K++ + E G+ E + + K KK KE K++ D K E
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 236 VKSQ----NGEFMTHKLKHTENT-----------FSRPGGRASVDTKEAEGAPQVEAGKR 280
+ + + T +K TEN + G + S D ++E ++ +
Sbjct: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSK 124
Query: 281 ---LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEAD 337
++ G + ++F KL +K + A +K ++ E+E+ +K +E
Sbjct: 125 KTAKPKVEMYSGSDDDDDFNKLPKKAKGKA------QKSNKKWDGSEEDEDNSKKIKERS 178
Query: 338 RKLREEEEKRRLKEEIERRRAEAAEKRQKMP---EDGLSDDKKPFKCFT----------- 383
R E E ++ R+ + ++ K E G DD FK T
Sbjct: 179 RINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKER 238
Query: 384 -------PKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 436
K K++E+ E L + S K + + + S++ T I ++
Sbjct: 239 ERKKRDEEKAKLRKLKEKEE-LETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE 297
Query: 437 AKPTKPAASD 446
T AA D
Sbjct: 298 KAETPTAAED 307
Score = 32.3 bits (72), Expect = 1.1
Identities = 23/119 (19%), Positives = 55/119 (46%), Gaps = 5/119 (4%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
+DD+E ++ E + +++EEE E + +E + + E S G
Sbjct: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG 562
Query: 61 QVTDQV---EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR--QKRLQEA 114
D+ E ++ ++ + +K +++++ + DD+ ER + +RR ++RL+ +
Sbjct: 563 DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHS 621
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 82.0 bits (201), Expect = 1e-15
Identities = 91/368 (24%), Positives = 159/368 (43%), Gaps = 74/368 (20%)
Query: 11 RRQKREEM--RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
RRQ EE RLE+ I ++ + ++ EA ++ R+A +ERLRQ+ +E ++ + E
Sbjct: 571 RRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQ 630
Query: 69 NAQNSVPD--EEAKTTTTNTQVEGDDEAAFLERL------ARREERRQKRLQEALERQKE 120
+ +V + E+ K T + D + LE L A++ E+ +K +E ER K
Sbjct: 631 IKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKN 690
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+E+K + + +EE + +Y
Sbjct: 691 ----------------------------QEKKIDYFERAKRLEEIPLIKSAY-------- 714
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 240
EE + +D + E++EE+ I Q++ EK + K + DR +K+
Sbjct: 715 EEQRIKDMDLWEQQEEE----RITTMQLEREKALEHKNRMSRMLE--DRDLFVMRLKAAR 768
Query: 241 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 300
KLK E + E RLEE +R+R E + + K
Sbjct: 769 QSVYEEKLKQFEERLAE------------------ERHNRLEERKRQRKEERRITYYREK 810
Query: 301 QKQQEAALELEELKKKREERRKV--LEEEEQRRKQEEADRKLREEEEKRRLKE-EIERRR 357
+++++ E E++ K+REER + + EE+ R+ +E +KL E E K+R +E EIE R
Sbjct: 811 EEEEQRRAE-EQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERE 869
Query: 358 AEAAEKRQ 365
E+R+
Sbjct: 870 RRREEERR 877
Score = 73.6 bits (179), Expect = 4e-13
Identities = 87/414 (21%), Positives = 166/414 (40%), Gaps = 56/414 (13%)
Query: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
+++ + R E +RE+ LE Q+ EEE R+ + +ER+ Q+ E+
Sbjct: 575 IEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKK 634
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
V +++E + + + K +E D + + + E+ +K LQE L+ Q++
Sbjct: 635 TVRERLEQIKKTELGAKAFKDIDIE-DLEELDPDFIMAKQVEQLEKEKKELQERLKNQEK 693
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ R + + + EE+ + +E +E E +T + + A
Sbjct: 694 --------KIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLERE--KA 743
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 240
E+K E+ + R + +EK+K+ +E E +R E K Q
Sbjct: 744 LEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAE-----ERHNRLEERKRQR 798
Query: 241 GEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKL 299
E ++ + RA KE E + E KR EELR + ++ E++
Sbjct: 799 KE--ERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREY--QERVKKLEEV 854
Query: 300 KQKQQEAALELEELKKKREERRKV-----------------------------------L 324
++K+++ LE+EE +++REE R++
Sbjct: 855 ERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPP 914
Query: 325 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKP 378
E+E +R + + DR R +EE+ R + E R ++P G+ DD+ P
Sbjct: 915 EKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGP 968
Score = 61.6 bits (148), Expect = 2e-09
Identities = 81/315 (25%), Positives = 130/315 (41%), Gaps = 64/315 (20%)
Query: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTE-KEEKSESRQERYEIEETETVTKSYQ 173
L+ ++E A L + Q A +T E ++E+ ES + E EE E Q
Sbjct: 543 LQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQ 602
Query: 174 KNDWRDAEENKKEDKEKEEEEE------------------EKPKRGSIGENQIKDEKI-- 213
K R AEE + + KE E+E E+ K+ +G KD I
Sbjct: 603 KV--RKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIED 660
Query: 214 ------------------KKDKEPKEEVKS------FMDRKKGFTEVKSQNGEFMTHKLK 249
K+ KE +E +K+ + +R K E+ + ++K
Sbjct: 661 LEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIK 720
Query: 250 HTENTFSRPGGRASVDTKEAEGAPQVE--AGKRLEE----LRRRRGETESEEFEKLKQKQ 303
+ + R + E E A + + + LE+ + R + +S EKLKQ +
Sbjct: 721 DMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFE 780
Query: 304 QEAALE----LEELKKKREERRKVL-----EEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
+ A E LEE K++R+E R++ EEEEQRR +E+ ++ E E R K E E
Sbjct: 781 ERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEE 840
Query: 355 RRRAEAAEKRQKMPE 369
R E E+ +K+ E
Sbjct: 841 LR--EYQERVKKLEE 853
Score = 37.7 bits (86), Expect = 0.027
Identities = 34/158 (21%), Positives = 72/158 (45%), Gaps = 13/158 (8%)
Query: 261 RASVDTKEAEGAPQVEAGK-----RLEELRRRRGET-----ESEEFEKLKQKQQEAALEL 310
R + D +E + P+ E + R + RR R E +EE + + +
Sbjct: 1211 RDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDR 1270
Query: 311 EELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR---QKM 367
++ +++R++RR + E + R ++ LR E E+ + R+ + E+R +++
Sbjct: 1271 DDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRV 1330
Query: 368 PEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 405
P LS D++ + +G K RAE +S++++
Sbjct: 1331 PPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRT 1368
Score = 36.6 bits (83), Expect = 0.060
Identities = 39/204 (19%), Positives = 80/204 (39%), Gaps = 17/204 (8%)
Query: 173 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKG 232
++ W E++ ++ + + E+E+ + E KD + ++D+E +DR+
Sbjct: 1185 REESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERD------VDREDR 1238
Query: 233 FTEVKSQNG--EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG- 289
F + + G + ++ R +E + + + L + R RRG
Sbjct: 1239 FRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGP 1298
Query: 290 --ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKR 347
+E EE ++ +EE R+ R+V R ++ + DR+ E EK
Sbjct: 1299 PLRSEREEVSSWRRADDRKDDRVEE----RDPPRRVPPPALSRDRERDRDRE--REGEKE 1352
Query: 348 RLKEEIERRRAEAAEKRQKMPEDG 371
+ E+ R + + EDG
Sbjct: 1353 KASWRAEKDRESLRRTKNETDEDG 1376
Score = 33.1 bits (74), Expect = 0.66
Identities = 43/217 (19%), Positives = 89/217 (41%), Gaps = 28/217 (12%)
Query: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE-----DKEKEEEEEEK 197
E E +E R+ R EE E + + D +D EEN K+ D+E++ + E++
Sbjct: 1180 EKEKAREESWGPPRESRPS-EEREWDREKERDRDNQDREENDKDPERERDRERDVDREDR 1238
Query: 198 PKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 257
+R +DE + + P EE S+ D + ++ + + ++
Sbjct: 1239 FRRP-------RDEGGWR-RGPAEESSSWRDSSR-------RDDRDRDDRRRERDDRRDL 1283
Query: 258 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKR 317
R D ++ G P + + RR + + ++++++ + L + R
Sbjct: 1284 RERRDLRDDRDRRGPPLRSEREEVSSWRR----ADDRKDDRVEERDPPRRVPPPALSRDR 1339
Query: 318 EERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
E R + E + K++ + R ++ E RR K E +
Sbjct: 1340 ERDR---DREREGEKEKASWRAEKDRESLRRTKNETD 1373
Score = 32.0 bits (71), Expect = 1.5
Identities = 39/200 (19%), Positives = 77/200 (38%), Gaps = 34/200 (17%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
D E+ R+ Q REE ND D E R R++R R+ ++E
Sbjct: 1204 DREKERDRDNQDREE------------NDKDPERERDRERDVDREDRFRRPRDEGGW--- 1248
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
+ +E + ++ + + D + ER RR+ R ++ L++ +R+
Sbjct: 1249 --------RRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRR---G 1297
Query: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSE------SRQERYEIEETETVTKSYQKND 176
P + + S R +D ++ E++ SR + + K +K
Sbjct: 1298 PPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEK--EKAS 1355
Query: 177 WRDAEENKKEDKEKEEEEEE 196
WR ++ + + K E +E+
Sbjct: 1356 WRAEKDRESLRRTKNETDED 1375
>gi|20070205 ladinin 1 [Homo sapiens]
Length = 517
Score = 80.9 bits (198), Expect = 3e-15
Identities = 109/527 (20%), Positives = 213/527 (40%), Gaps = 54/527 (10%)
Query: 25 IAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPD-EEAKTTT 83
+A QR +DEEE RERRRR R E L Q D+ + +A +P EEA+
Sbjct: 14 LARQRTLEDEEEQERERRRRHRNLSSTTDDEAPRLSQNGDR-QASASERLPSVEEAEVPK 72
Query: 84 TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143
D++ L R+ERRQ+R + +A+ + R++ +
Sbjct: 73 PLPPASKDEDEDIQSILRTRQERRQRR-------------QVVEAAQAPIQERLEAEEGR 119
Query: 144 NETT--EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRG 201
N + + +K ++ EI +++ Q+ W EE +E EE ++ P++
Sbjct: 120 NSLSPVQATQKPLVSKKELEIPPRRRLSRE-QRGPWA-LEEESLVGREPEERKKGVPEKS 177
Query: 202 SIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 261
+ E +K +K + S ++ V + ++ K+ +E S +
Sbjct: 178 PVLEKSSMPKKTAPEKSLVSDKTSISEK------VLASEKTSLSEKIAVSEKRNS--SEK 229
Query: 262 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 321
SV K + + G L RR E ++ FEK ++ + + K+
Sbjct: 230 KSVLEKTSVSEKSLAPGMALGSGRRLVSE-KASIFEKALASEKSPTADAKPAPKRATASE 288
Query: 322 KVLEEE-----------EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMP-E 369
+ L +E +++R + + L ++ R + K+P +
Sbjct: 289 QPLAQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVASRLPPVTLQVKIPSK 348
Query: 370 DGLSDDKKP--------FKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKID 421
+ +D P K +P+ S +++ + E ++ +S+ +K K+
Sbjct: 349 EEEADMSSPTQRTYSSSLKRSSPRTISFRMKPKKENSETTLTRSASMKLPDNTV---KLG 405
Query: 422 SRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETA 481
+LE+Y +AI ++S K ++L V GV + + ++EK S + KE
Sbjct: 406 EKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKELAGQSRAEPASSRKENL 465
Query: 482 GLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQS 528
L V+SR+N W+++T +S P + + +++R W ++S
Sbjct: 466 RLSGVVTSRLNLWISRT---QESGDQDPQEAQKASSATERTQWGQKS 509
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 80.5 bits (197), Expect = 4e-15
Identities = 89/364 (24%), Positives = 170/364 (46%), Gaps = 73/364 (20%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E++RL E+E+ Q N D + + Q++L+ E + LG+
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV--EADRLGKEL 271
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
V Q V + E N Q E E++ R+EE+ +QE E+ E +
Sbjct: 272 QSVSAKLQAQVEENEL-WNLLNQQQE--------EKMWRQEEK----IQEQEEKMCEQEL 318
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
I + + + + E + E+E+K ++E+ I E E + ++ WR E+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--IREQEEKIREQEEKMWRQEEKI 376
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 243
+++D++ +E+EEE ++ +EKI++ +E ++E K + KK ++ Q+
Sbjct: 377 REQDEKIQEQEEEMWRQ---------EEKIREQEEKRQE-KMWRQEKK----MREQD--- 419
Query: 244 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 303
K++ E EE+ R+ E + E E++ Q Q
Sbjct: 420 --EKIREQE-----------------------------EEMWRQ--EEKIRELEEMMQDQ 446
Query: 304 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 363
+E E+EE K +EE K+ E+EE+ ++QEE K++E+EEK +E++ ++ + E+
Sbjct: 447 EEKLREVEE--KMQEEEEKMQEQEEKIQRQEE---KIQEQEEKTWRQEKLLKQEEKIWEQ 501
Query: 364 RQKM 367
+KM
Sbjct: 502 EEKM 505
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/303 (22%), Positives = 133/303 (43%), Gaps = 68/303 (22%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER A L
Sbjct: 208 RNTITDEELKEKNAELQ----EKLRLVESEKSEIQLNVKDLKRKLER----------AQL 253
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET---VTKSYQKNDWRDAEENKKED 187
LP +++Q E + KE +S S + + ++EE E + + ++ WR EE +E
Sbjct: 254 LLPQQQLQ---VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQ-EEKIQEQ 309
Query: 188 KEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 247
+EK E+E K + ++EK+ + +E E + K
Sbjct: 310 EEKMCEQELKIRE--------QEEKMWRQEEKMHEQEE---------------------K 340
Query: 248 LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAA 307
++ E+ R Q E + EE R + E + EK++++ ++
Sbjct: 341 IREQEDKMWR----------------QEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQ 384
Query: 308 LELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKM 367
+ EE+ ++ E+ R+ +EE+++ K ++K+RE++EK R +EE R+ E + ++M
Sbjct: 385 EQEEEMWRQEEKIRE--QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442
Query: 368 PED 370
+D
Sbjct: 443 MQD 445
Score = 58.5 bits (140), Expect = 1e-08
Identities = 68/312 (21%), Positives = 137/312 (43%), Gaps = 29/312 (9%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ + E R++ ++M + E+I Q E+E R+ +E+ + QE+E +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE--E 389
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ Q E + +E E D++ E R+E + + L+E ++ Q+E
Sbjct: 390 MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE- 448
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
L +MQ + E + E+EEK + ++E+ + +E +T WR +
Sbjct: 449 -------KLREVEEKMQEE--EEKMQEQEEKIQRQEEKIQEQEEKT---------WRQEK 490
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
K+E+K E+EE+ + + E + K ++ ++ + +EE + + E K Q
Sbjct: 491 LLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQ 550
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR-RRGETESEEFEKLK 300
E +L+ E + G +A + GA + +RL L + E +S+E + L+
Sbjct: 551 EV---RLQELEERLGKLGQKAEL----LGGAGRESGSQRLPTLTPILQVELKSQEAQSLQ 603
Query: 301 QKQQEAALELEE 312
Q+Q L++
Sbjct: 604 QQQDHYRGHLQQ 615
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 80.5 bits (197), Expect = 4e-15
Identities = 89/364 (24%), Positives = 170/364 (46%), Gaps = 73/364 (20%)
Query: 5 ERRRELRRQKREEMRL-EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT 63
E +E + +E++RL E+E+ Q N D + + Q++L+ E + LG+
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV--EADRLGKEL 271
Query: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDP 123
V Q V + E N Q E E++ R+EE+ +QE E+ E +
Sbjct: 272 QSVSAKLQAQVEENEL-WNLLNQQQE--------EKMWRQEEK----IQEQEEKMCEQEL 318
Query: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
I + + + + E + E+E+K ++E+ I E E + ++ WR E+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--IREQEEKIREQEEKMWRQEEKI 376
Query: 184 KKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 243
+++D++ +E+EEE ++ +EKI++ +E ++E K + KK ++ Q+
Sbjct: 377 REQDEKIQEQEEEMWRQ---------EEKIREQEEKRQE-KMWRQEKK----MREQD--- 419
Query: 244 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 303
K++ E EE+ R+ E + E E++ Q Q
Sbjct: 420 --EKIREQE-----------------------------EEMWRQ--EEKIRELEEMMQDQ 446
Query: 304 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK 363
+E E+EE K +EE K+ E+EE+ ++QEE K++E+EEK +E++ ++ + E+
Sbjct: 447 EEKLREVEE--KMQEEEEKMQEQEEKIQRQEE---KIQEQEEKTWRQEKLLKQEEKIWEQ 501
Query: 364 RQKM 367
+KM
Sbjct: 502 EEKM 505
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/303 (22%), Positives = 133/303 (43%), Gaps = 68/303 (22%)
Query: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASL 130
+N++ DEE K Q ++ +E + K L+ LER A L
Sbjct: 208 RNTITDEELKEKNAELQ----EKLRLVESEKSEIQLNVKDLKRKLER----------AQL 253
Query: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET---VTKSYQKNDWRDAEENKKED 187
LP +++Q E + KE +S S + + ++EE E + + ++ WR EE +E
Sbjct: 254 LLPQQQLQ---VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQ-EEKIQEQ 309
Query: 188 KEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHK 247
+EK E+E K + ++EK+ + +E E + K
Sbjct: 310 EEKMCEQELKIRE--------QEEKMWRQEEKMHEQEE---------------------K 340
Query: 248 LKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAA 307
++ E+ R Q E + EE R + E + EK++++ ++
Sbjct: 341 IREQEDKMWR----------------QEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQ 384
Query: 308 LELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKM 367
+ EE+ ++ E+ R+ +EE+++ K ++K+RE++EK R +EE R+ E + ++M
Sbjct: 385 EQEEEMWRQEEKIRE--QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442
Query: 368 PED 370
+D
Sbjct: 443 MQD 445
Score = 58.5 bits (140), Expect = 1e-08
Identities = 68/312 (21%), Positives = 137/312 (43%), Gaps = 29/312 (9%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
+ + E R++ ++M + E+I Q E+E R+ +E+ + QE+E +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE--E 389
Query: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
+ Q E + +E E D++ E R+E + + L+E ++ Q+E
Sbjct: 390 MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE- 448
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
L +MQ + E + E+EEK + ++E+ + +E +T WR +
Sbjct: 449 -------KLREVEEKMQEE--EEKMQEQEEKIQRQEEKIQEQEEKT---------WRQEK 490
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
K+E+K E+EE+ + + E + K ++ ++ + +EE + + E K Q
Sbjct: 491 LLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQ 550
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR-RRGETESEEFEKLK 300
E +L+ E + G +A + GA + +RL L + E +S+E + L+
Sbjct: 551 EV---RLQELEERLGKLGQKAEL----LGGAGRESGSQRLPTLTPILQVELKSQEAQSLQ 603
Query: 301 QKQQEAALELEE 312
Q+Q L++
Sbjct: 604 QQQDHYRGHLQQ 615
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 79.7 bits (195), Expect = 6e-15
Identities = 95/394 (24%), Positives = 169/394 (42%), Gaps = 50/394 (12%)
Query: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQE--EESLGQVTD 64
R E+ R E L AE+ +++ D +E+E +ER + ++ER ++ +E EE G+ +
Sbjct: 683 RGEMERPGEGEKEL-AEKEEWKKRDGEEQEQ-KEREQGHQKERNQEMEEGGEEEHGEGEE 740
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
+ + + E K +VEG+ E ER ++EER K E+ +E
Sbjct: 741 EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGER--KKEERAGKE-----EKGEE---- 789
Query: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT-KSYQKNDWRDAE-- 181
+ D E E E E + E ++E E+E E K ++ + + E
Sbjct: 790 -------------EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGE 836
Query: 182 ----ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 237
E ++E+ E EEEE E E + ++E + + E +EE ++G E +
Sbjct: 837 EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE 896
Query: 238 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 297
+ GE + E G+ + +E EG + E G+ E GE E E+E
Sbjct: 897 EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE 956
Query: 298 KLKQ--------------KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREE 343
++ ++ E E EE + + EE E EE+ +EE + + EE
Sbjct: 957 GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE-GEE 1015
Query: 344 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 377
EE+ ++ E+E E + ++ E+G +K+
Sbjct: 1016 EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKE 1049
Score = 77.8 bits (190), Expect = 2e-14
Identities = 98/429 (22%), Positives = 173/429 (40%), Gaps = 45/429 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
+R E + QK E + ER + + EE E +E +++EEE G+ +
Sbjct: 704 KRDGEEQEQKEREQGHQKER------NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKE 757
Query: 65 Q---VEVNAQNSVPD-EEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
+ EV + + E K + +G++E E E R + +E E +
Sbjct: 758 EGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVE-- 815
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ + + + E E +EE+ E +E E EE E K ++ + +
Sbjct: 816 --------GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEG 867
Query: 181 EENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 240
EE +E + + EEEE + + GE + ++E+ + + E + E + + +G E + +
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
Query: 241 GEFMTHKLKHTENTFSRPGGRASVDTKEA---------------EGAPQVEAGKRLEELR 285
GE + + E G + +E EG + E G+ E
Sbjct: 928 GE---GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEE 984
Query: 286 RRRGETESEEFEKLKQKQQEAALELE---ELKKKREERRKVLEEEEQRRKQEEADRKLRE 342
GE E EE E+ +++ E E E E +++ E +V EE + +EE + E
Sbjct: 985 EGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGE 1044
Query: 343 EEEKRRLKEEIERRRAEAAEKRQKMPEDGLSD----DKKPFKCFTPKGSSLKIEERAEFL 398
E EK EE R R E E+ K E G + D + +K + S+K + +
Sbjct: 1045 EREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQ 1104
Query: 399 NKSVQKSSG 407
KSV + G
Sbjct: 1105 KKSVTNTQG 1113
Score = 72.8 bits (177), Expect = 8e-13
Identities = 98/423 (23%), Positives = 171/423 (40%), Gaps = 43/423 (10%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQK------QE 55
++ E RE +K E + E E + + EE ++ R ++E+ ++ +E
Sbjct: 739 EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEAL 115
EE+ G+ ++ E EE K + EG+ E E EE + +E
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGE----EEEGEGEEEEGEGEEEEG 854
Query: 116 ERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEE-KSESRQERYEIEETETVTKSYQK 174
E + E + + + + E E +EE + E +E E E E ++
Sbjct: 855 EGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914
Query: 175 NDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFT 234
+ E + E+ E E EEEE G GE + ++E+ + + E +E + +G
Sbjct: 915 EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG 974
Query: 235 EVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE-ELRRRRGETES 293
E GE + + E G +E EG + E +E E+ GE E
Sbjct: 975 EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEG 1034
Query: 294 EEFEKLKQ-KQQEAALELEELKKKREERRKVLEEEEQRRKQE--EADRKLREEEEKRRL- 349
EE E ++ +++E E EE ++ REE EEEE+ + QE E + + ++ EE +++
Sbjct: 1035 EEEEGEEEGEEREKEGEGEENRRNREE-----EEEEEGKYQETGEEENERQDGEEYKKVS 1089
Query: 350 ---------------KEEIERRRAEAAEKRQKMP-------EDGLSDDKKPFKCFTPKGS 387
K+ + + E+R KMP ++G S KK + P
Sbjct: 1090 KIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWNNVLPHYL 1149
Query: 388 SLK 390
LK
Sbjct: 1150 ELK 1152
Score = 69.7 bits (169), Expect = 6e-12
Identities = 89/381 (23%), Positives = 156/381 (40%), Gaps = 46/381 (12%)
Query: 10 LRRQKREEMRLE-AERIAYQRNDDDEE--EAARERRRRARQERLRQ-------------- 52
+++QK+++ E + A NDD +E E + + +A ++ + Q
Sbjct: 520 VQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAF 579
Query: 53 KQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF------LERLARREER 106
EE + + + E + N + ++E + N +V G + L A E
Sbjct: 580 SDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEG 639
Query: 107 RQKRLQEALERQK-EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165
+ K + EA + + D T + S AE+ E+ EK E + R E+E
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCEEGSSG----------AEHWQDEEREKGEKDKGRGEMERP 689
Query: 166 ETVTKSY-QKNDW--RDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEE 222
K +K +W RD EE +++++E+ ++E + GE + + + ++ +EE
Sbjct: 690 GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
Query: 223 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE 282
K +++G E E + K E G D E E G+ E
Sbjct: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKE 809
Query: 283 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLRE 342
E GE E E E+ K +++E EE + + EE EEEE ++EE + K E
Sbjct: 810 E----GGEVEGGEVEEGKGEREE-----EEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE 860
Query: 343 EEEKRRLKEEIERRRAEAAEK 363
E E+ +EE E E E+
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEE 881
Score = 56.2 bits (134), Expect = 7e-08
Identities = 77/359 (21%), Positives = 152/359 (42%), Gaps = 49/359 (13%)
Query: 42 RRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEA-----------KTTTTNTQVEG 90
+++ +Q+ + + ++ +L + D E + + + +A T +
Sbjct: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS 580
Query: 91 DDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 150
D+E E E+ + ++E E + + R+ + + ++ T+K
Sbjct: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGG------RKEKTEILSDDLTDKA 634
Query: 151 EKSESRQERYEIEETETVTK----------SYQKNDWRDAEENKKEDKEKEEEEEEKPKR 200
E SE + + + E E + S W+D EE +K +K+K E E+P
Sbjct: 635 EVSEGKAK--SVGEAEDGPEGRGDGTCEEGSSGAEHWQD-EEREKGEKDKGRGEMERPGE 691
Query: 201 GSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 260
G E K+E K+D E +E+ + +K + + GE +H E G
Sbjct: 692 GE-KELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEE-----EHGEGE-EEEGD 744
Query: 261 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 320
R + KE EG + E G+ +E GE E EE E+ K++E A + E+ +++ ++
Sbjct: 745 REEEEEKEGEGKEEGE-GEEVE------GEREKEEGER---KKEERAGKEEKGEEEGDQG 794
Query: 321 RKVLEEEEQRRKQEEADRKLR--EEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 377
EE E R +++E ++ E EE + +EE E E+ + E+G ++++
Sbjct: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
Score = 46.6 bits (109), Expect = 6e-05
Identities = 73/312 (23%), Positives = 129/312 (41%), Gaps = 53/312 (16%)
Query: 141 TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE---DKEKEEEEEEK 197
T + TE ++ S+ +E E++E + + + + E D+E E EE++
Sbjct: 533 TQDTALTENDD-SDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKE 591
Query: 198 PKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 257
S G N I++++++ ++E VK RK+ TE+ S + +T K + +E
Sbjct: 592 GAEDSKG-NGIEEQEVEANEE---NVKVHGGRKEK-TEILSDD---LTDKAEVSEGKAKS 643
Query: 258 PGGRASVDTKEAEGAPQVEAG----KRLEELRRRRGETESEEFEKLKQKQQEAALELEEL 313
G + D E G E G + ++ R +GE + E + + E L +E
Sbjct: 644 VG--EAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEE 701
Query: 314 KKKREERRKVLEEEEQRR-------------------KQEEADRKLREEE---------- 344
KKR+ + +E EQ ++EE DR+ EE+
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG 761
Query: 345 ---EKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKS 401
E R KEE ER++ E A K +K E+G D+ + +G + EE E
Sbjct: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEG---DQGEGEEEETEGRGEEKEEGGEVEGGE 818
Query: 402 VQKSSGVKSTHQ 413
V++ G + +
Sbjct: 819 VEEGKGEREEEE 830
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 79.7 bits (195), Expect = 6e-15
Identities = 93/396 (23%), Positives = 172/396 (43%), Gaps = 62/396 (15%)
Query: 28 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV--NAQNSVPDEEAKTTTTN 85
QR ++ + ER+RR Q+ L +++ + L + +Q+E N EE +
Sbjct: 112 QRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI 171
Query: 86 TQV-------EGDDEAAFLERLARREERRQKRLQEALE-RQKEFDPTITDAS-LSLPSRR 136
T V G + F + REE+ + + +E R +E P++ +A LSL
Sbjct: 172 TVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSL---- 227
Query: 137 MQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEE 196
+ +D E+E K+E + + EE E + Q+N + AEE ++ E+E+ E
Sbjct: 228 VMDDEIESEA--KKESLSPGKLKLTFEELE---RQRQENRKKQAEEEARKRLEEEKRAFE 282
Query: 197 KPKRGSIGENQI----------------------------KDEKIKKDKEPKEEVKSFMD 228
+ +R + E++ +DEK K ++E + ++ +
Sbjct: 283 EARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIE---E 339
Query: 229 RKKGFTEVKSQN--GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR 286
KK F E + + K F PG + ++ +E E +R EE R+
Sbjct: 340 EKKAFAEARRNMVVDDDSPEMYKTISQEFLTPG-KLEINFEELLKQKMEEEKRRTEEERK 398
Query: 287 RRGETESEEFEKLKQKQQEAALELEELKKKRE-------ERRKVLEEEEQRRKQEEADRK 339
+ E E +EFE+L+Q+ E E E RE +R ++ + + K E+ +
Sbjct: 399 HKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIG-Q 457
Query: 340 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 375
L E+E +++++EE RRRA E +++ E+ +D
Sbjct: 458 LSEKEIQKKIEEERARRRAIDLEIKEREAENFHEED 493
Score = 75.1 bits (183), Expect = 2e-13
Identities = 89/410 (21%), Positives = 172/410 (41%), Gaps = 60/410 (14%)
Query: 4 FERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE------------RRRRARQERLR 51
+E + +R +++ EA+ ++ +D+ E EA +E R RQE +
Sbjct: 204 YEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRK 263
Query: 52 QKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLE-------RLARRE 104
++ EEE+ ++ ++ EEA+ N E D A + +L+ E
Sbjct: 264 KQAEEEARKRLEEEKRAF-------EEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEE 316
Query: 105 ERRQKRLQEALERQKEFDPTITDASLSLPSRR----MQNDTAENETTEKEEKSESRQERY 160
RQ+R E + ++E I + + R + +D+ E T +E +
Sbjct: 317 MERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEI 376
Query: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPK 220
EE + K + + R EE +K E E++E E+ R +GE + ++E +E +
Sbjct: 377 NFEE---LLKQKMEEEKRRTEEERKHKLEMEKQEFEQ-LRQEMGEEEEENETFGLSREYE 432
Query: 221 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 280
E +K ++G LK + F + G + KE + + E +R
Sbjct: 433 ELIKL------------KRSGSIQAKNLK---SKFEKIG---QLSEKEIQKKIEEERARR 474
Query: 281 LE---ELRRRRGETESEEFE---KLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE 334
E++ R E EE + + +K + +K + E+ K EEEEQRR +E
Sbjct: 475 RAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEE 534
Query: 335 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTP 384
+ + LR + E+R + ++++R E E+ + ++D++ + P
Sbjct: 535 Q--KLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAP 582
Score = 74.7 bits (182), Expect = 2e-13
Identities = 115/483 (23%), Positives = 202/483 (41%), Gaps = 90/483 (18%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
D + + E ++ REE QR DE++ +E+ R R+ R+KQE + +
Sbjct: 30 DVKDKFEAMQRAREERN--------QRRSRDEKQRRKEQYIREREWN-RRKQEIKEMLAS 80
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
D+ +V+++ E+A V+G F E +R+E ++KR +E +R+ E D
Sbjct: 81 DDEEDVSSKV----EKAYVPKLTGTVKG----RFAEMEKQRQEEQRKRTEEERKRRIEQD 132
Query: 123 PTITDASLSLPSRRMQNDTAEN-------ETTEKEEKSESRQERYEIEETETVTKSYQ-- 173
L R++Q + A+ T E SE + I T KSY+
Sbjct: 133 --------MLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLI--TVVPVKSYKTS 182
Query: 174 ---KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKI-------KKDKEPKEEV 223
K ++ D E+ ++E+KE+ + EE+K R +K+ K + + E K+E
Sbjct: 183 GKMKKNFEDLEK-EREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKES 241
Query: 224 KSFMDRKKGFTEV--------KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 275
S K F E+ K Q E +L+ + F + + +E + ++
Sbjct: 242 LSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKI 301
Query: 276 EAGKRLEELRRRRGETESEEFEKLKQK-QQEAALELEELKKKREERRK--VLEE------ 326
G R +L+ E E + E K+K ++EA +EE KK E R+ V+++
Sbjct: 302 FKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMY 361
Query: 327 -----------------EEQRRKQEEADRKLREEEEKRRL---KEEIERRRAEAAEKRQK 366
EE +++ E +++ EEE K +L K+E E+ R E E+ ++
Sbjct: 362 KTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE 421
Query: 367 MPEDGLSDDKKPFKCFTPKGS------SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKI 420
GLS + + GS K E+ + K +QK + + AI +I
Sbjct: 422 NETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEI 481
Query: 421 DSR 423
R
Sbjct: 482 KER 484
Score = 68.9 bits (167), Expect = 1e-11
Identities = 77/308 (25%), Positives = 141/308 (45%), Gaps = 22/308 (7%)
Query: 89 EGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTE 148
+GD + F REER Q+R ++ +R+KE I + + RR Q + +
Sbjct: 28 KGDVKDKFEAMQRAREERNQRRSRDEKQRRKE--QYIREREWN---RRKQEIKEMLASDD 82
Query: 149 KEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQI 208
+E+ S ++ Y + T TV K + + E+ ++E++ K EEE K + I ++ +
Sbjct: 83 EEDVSSKVEKAYVPKLTGTV-----KGRFAEMEKQRQEEQRKRTEEERKRR---IEQDML 134
Query: 209 KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 268
+ KI+++ + E D TE S+ G+ ++ + G+ + ++
Sbjct: 135 EKRKIQRELAKRAE--QIEDINNTGTESASEEGDDSLLITVVPVKSY-KTSGKMKKNFED 191
Query: 269 AEGAPQVEAGKRLEELRRRRGETESEEFEKLK--QKQQEAALELEELKKKREERRKVLEE 326
E + + + EE +R R E + ++ K + +E E K+ + L
Sbjct: 192 LEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTF 251
Query: 327 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK-KPFKCFTPK 385
EE R+++E +K EEE ++RL+EE +RA +RQ + ED + D K FK + P
Sbjct: 252 EELERQRQENRKKQAEEEARKRLEEE---KRAFEEARRQMVNEDEENQDTAKIFKGYRPG 308
Query: 386 GSSLKIEE 393
L EE
Sbjct: 309 KLKLSFEE 316
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/202 (22%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 238 SQNGEFMTHKLKHTENTFSRPGGRASVDTK-EAEGAPQVEAGKRL---EELRRRRGETES 293
SQ E + K T+ G+ V K EA + E +R E+ RR+
Sbjct: 5 SQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRE 64
Query: 294 EEFEKLKQK---------QQEAALELEEL-----------------KKKREERRKVLEEE 327
E+ + KQ+ +++ + ++E+ K+++EE+RK EEE
Sbjct: 65 REWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEE 124
Query: 328 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 387
+RR +++ K + + E + E+IE E + +D L P K + G
Sbjct: 125 RKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG- 183
Query: 388 SLKIEERAEFLNKSVQKSSGVK 409
K+++ E L K ++ +K
Sbjct: 184 --KMKKNFEDLEKEREEKERIK 203
Score = 40.4 bits (93), Expect = 0.004
Identities = 54/245 (22%), Positives = 104/245 (42%), Gaps = 39/245 (15%)
Query: 1 MDDFERRRELRRQKREEM-RLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
M++ +RR E R+ + EM + E E++ + +++EE E +E E L
Sbjct: 386 MEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE-----------NETFGLSREYEEL 434
Query: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
++ + A+N E + +++ E ER RR + + +EA +
Sbjct: 435 IKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEE---ERARRRAIDLEIKEREAENFHE 491
Query: 120 EFDPTITDASLS-LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
E D + A S P N A E+ K+ +E+ IEE + + +++ +
Sbjct: 492 EDDVDVRPARKSEAPFTHKVNMKAR---FEQMAKAREEEEQRRIEEQKLLRMQFEQREID 548
Query: 179 DAEENKKEDKEKEE---------EEEEKPKRG-----------SIGENQIKDEKIKKDKE 218
A + K+E++E+EE E+EE+ + G S+ +++ +K E
Sbjct: 549 AALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGE 608
Query: 219 PKEEV 223
PK E+
Sbjct: 609 PKPEI 613
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 79.3 bits (194), Expect = 8e-15
Identities = 81/321 (25%), Positives = 148/321 (46%), Gaps = 32/321 (9%)
Query: 72 NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE----RRQKRLQEALERQKEFDPTITD 127
NS P+ + ++ T G EA + RE RR++ ++A+ E + + D
Sbjct: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDE-EQHLED 468
Query: 128 ASLSLP-SRRMQNDTAENETTEKEEKSESRQERYEIEETET-----VTKSYQKN------ 175
L P S+ + ++ +R ++ T T V KS+ K
Sbjct: 469 EELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM 528
Query: 176 DWRDAEENKKEDKEKEEEEE-------EKPKRGSIGENQIK-DEKIKKDKEPKEEVKSFM 227
D ++ E + E+ ++EE E E+ KR + E ++K +E+++K + +E V+
Sbjct: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
Query: 228 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 287
+ KK E K + T K K E + + K+ E +VEA ++ EE RR
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKME---EVEARRKQEEEARR 643
Query: 288 RGETESEEFEKLKQK--QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 345
+ EE E+ Q+ Q++ E E L+K E +R + E++RR+QE +++ RE+E
Sbjct: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 703
Query: 346 KRRLKEEIERRRAEAAEKRQK 366
+ + + E ER+ AE +R++
Sbjct: 704 REQERREQERQLAEQERRREQ 724
Score = 69.3 bits (168), Expect = 8e-12
Identities = 83/359 (23%), Positives = 146/359 (40%), Gaps = 51/359 (14%)
Query: 16 EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVP 75
EE LE E + R+ + R + L Q + L T +A SV
Sbjct: 462 EEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPT-----SAPRSVM 516
Query: 76 DEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSR 135
K T + E LE L R+EE Q R Q+ E ++ R
Sbjct: 517 KSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR---------------R 561
Query: 136 RMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE 195
R++ E + +E + Q R +E+ + EE KK+ ++K + +
Sbjct: 562 RLE----EVKLKREERLRKVLQARERVEQMK--------------EEKKKQIEQKFAQID 603
Query: 196 EKPKRGSIGENQIKDEKIKKDKEPK--EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 253
EK ++ E ++ +EK KK K EEV++ R+K E + + + +
Sbjct: 604 EKTEKAK--EERLAEEKAKKKAAAKKMEEVEA---RRKQEEEARRLRWLQQEEEERRHQE 658
Query: 254 TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEEL 313
+ ++A A ++ + E + R E E E E+ +Q+++E +L E
Sbjct: 659 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ 718
Query: 314 KKKREERRKVLEEEEQRRKQ------EEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
+++RE+ R E E Q R++ E+ R+L E+++K + ER+ E EK+ K
Sbjct: 719 ERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
Score = 68.6 bits (166), Expect = 1e-11
Identities = 61/237 (25%), Positives = 111/237 (46%), Gaps = 26/237 (10%)
Query: 5 ERRRELRRQKREE-MRLEAERIAYQRNDDDEEEA-ARERRRRARQERLRQKQEEESLGQV 62
E +LRRQK EE R E + +R + + ARER + ++E+ +KQ E+ Q+
Sbjct: 545 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK--KKQIEQKFAQI 602
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEG-------DDEAAFLERLARREERR--QKRLQE 113
++ E + + +E+AK ++E ++EA L L + EE R Q+ LQ+
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
Query: 114 ALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQ 173
E ++E +A R + E E+ E+ QER E +E + + +
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE-QERQLAEQERR 721
Query: 174 KNDWRDAEENKKEDKEKE------------EEEEEKPKRGSIGENQIKDEKIKKDKE 218
+ R E + +++EK EE+++K ++ + E Q+++E+ KK KE
Sbjct: 722 REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
Score = 59.7 bits (143), Expect = 7e-09
Identities = 76/344 (22%), Positives = 136/344 (39%), Gaps = 47/344 (13%)
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET-----TEK 149
++LERL E QK E E +E +P + A +P N N+T T
Sbjct: 357 SYLERLLNVEVP-QKVGSEQKEPPEEAEP-VAAAEPEVPENNGNNSWPHNDTEIANSTPN 414
Query: 150 EEKSESRQERYEIEETETVT-----------KSYQKNDWRDAEENKKEDKEKEEEEEEKP 198
+ + S E + E T + +K ++ A E++ E+EE + P
Sbjct: 415 PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPP 474
Query: 199 K-----------------RGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+ R + Q + P+ +KSF+ R +
Sbjct: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKE 534
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 301
L+ E + D + +++ +RL ++ + R E + EK KQ
Sbjct: 535 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
Query: 302 KQQEAALELEELKKKREERRKVLEEEEQRRK-----QEEADRKLREEEEKRRLK----EE 352
+Q+ A E+ +K +EER L EE+ ++K EE + + ++EEE RRL+ EE
Sbjct: 595 IEQKFAQIDEKTEKAKEER---LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 651
Query: 353 IERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
ERR E +K+++ ++ L + + + + +ER E
Sbjct: 652 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 695
Score = 47.4 bits (111), Expect = 3e-05
Identities = 38/152 (25%), Positives = 76/152 (50%), Gaps = 16/152 (10%)
Query: 2 DDFERRRELRRQKREEMR------LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQE 55
++ R +EL ++K+EE + EA+R+A QR + E+ RE+ RR ++ R ++++E
Sbjct: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 710
Query: 56 EE----SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDE----AAFLERLARR--EE 105
+E + +Q + A+ + + E Q++ + E +RLA R +E
Sbjct: 711 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 770
Query: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRM 137
++K+ +EA K + T+ S + S +M
Sbjct: 771 EQEKKAKEAAGASKALNVTVDVQSPACTSYQM 802
Score = 45.4 bits (106), Expect = 1e-04
Identities = 72/373 (19%), Positives = 147/373 (39%), Gaps = 48/373 (12%)
Query: 100 LARREERRQKRLQEALERQKEFDPTITDASL--SLPSRRMQNDTAENETTEKEEKSESRQ 157
L ++E +R L ++ +P + + S R + + + +E++E E +
Sbjct: 324 LVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAE 383
Query: 158 ERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDK 217
E V ++ N W + + P+ S G+ + K ++ +
Sbjct: 384 PVAAAEPE--VPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPR 441
Query: 218 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 277
EP + + RK+ + + S+ E +H E+ +P R+ + + V
Sbjct: 442 EPPQSAR----RKRSYKQAVSELDEE-----QHLEDEELQPP-RSKTPSSPCPASKVVRP 491
Query: 278 GKR-LEELRRRR-----GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRR 331
+ L ++R + + ++ ++ +E +++R E + EE EQ R
Sbjct: 492 LRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLR 551
Query: 332 KQE-EADR-------KLREEEEKRRL--------------KEEIERRRAEAAEKRQKMPE 369
+Q+ E D+ KL+ EE R++ K++IE++ A+ EK +K E
Sbjct: 552 RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
Query: 370 DGLSDDKKPFKCFTPKGSSL----KIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLE 425
+ L+++K K K + K EE A L Q+ + HQ + K + E
Sbjct: 612 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE--ERRHQELLQKKKEEEQE 669
Query: 426 QYTSAIEGTKSAK 438
+ A E + A+
Sbjct: 670 RLRKAAEAKRLAE 682
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/502 (23%), Positives = 219/502 (43%), Gaps = 83/502 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1745 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A L LA +R+++ +E RQ+ + L+ + T E E KE+++E
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAE 1862
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ----IKD 210
+ + R E+ +++Q+ R EE + K EE + ++ S E + + +
Sbjct: 1863 NERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 211 EKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 266
+ +++ ++ +EE+ SF G E++ + G + + E+T S +
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDTL------RSKEQ 1964
Query: 267 KEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-ELEELKKKREERRK 322
E E A Q + EE RRR E +S E+ +Q++AAL E+E LK K EE R+
Sbjct: 1965 AELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 323 VLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 376
+ E EQ + QE A ++L+ EE+ + + + + ++++ D L +
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 377 KPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 424
+ + + +++ E AE L +S ++ + ++ QAA K+
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEA 2142
Query: 425 EQYTSAIEGTKSAKPTKPAASD 446
EQ + + A + A+D
Sbjct: 2143 EQEAARRAQAEQAALRQKQAAD 2164
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 39/398 (9%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1481 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1600 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 181 EE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE-------EVKSF 226
+ + +K+KEE E E +RG ++ + ++ +++++K ++ E +
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 227 MDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVEAGKRL 281
+ R + TE Q + + +L + T R A + AE + + R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 282 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQEEADRK 339
EE R E + E + +E A E L+ EE R++ L EE+ R++ EA+R
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 340 LREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 370
L E+ E RLK E E + + E+ +++ ED
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/428 (24%), Positives = 169/428 (39%), Gaps = 46/428 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER R ++ +RL+ E QR + E A R + + RQ QEE +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEA-LERQKEF 121
Q E + E A + + + A LE L + E ++RL++A +ER ++
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ A S + + E T + E+S ++E ++ R A+
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLERS--------LQEEHVAVAQLREEAERRAQ 1615
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+ + ++ +EE E E + Q+K + + + EEV + E + +
Sbjct: 1616 QQAEAERAREEAERE------LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EELRRRRGETESEE--- 295
E + E R A + ++ + A +RL +EL R R ETE E
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 296 ---FEKLKQKQQEAAL------ELE-ELKKKREERR-----KVLEEEEQRRKQEEADRKL 340
E+L + Q+EAA ELE EL K R E K EEE R E++ ++L
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 341 REEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKPFKCFTPK----GSSLKIE 392
E + R L EE R RA EA +RQ ED + + K G + +++
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 393 ERAEFLNK 400
AE K
Sbjct: 1850 TEAEIALK 1857
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/412 (21%), Positives = 168/412 (40%), Gaps = 69/412 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1783 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 170 KSYQKNDWRDAEENK---KEDKEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKE 221
+S ++ + A + + +E++ + E EE K + E + E++++ K E
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 222 EVKSFMDR-----------------------KKGFTEVKSQNGEFMTHKLKHTENTFSRP 258
E + +R +K Q + + L+ ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 259 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 318
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 319 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 363
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2137 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/410 (21%), Positives = 175/410 (42%), Gaps = 27/410 (6%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
+ +++ + K E E +R + E ++ +++ ++ K + + + +
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
K F+ + + + + R SV +EA Q+ E+L ++R
Sbjct: 2259 KDNTQRFLQEEAEKMKQV-AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA----- 2308
Query: 297 EKLKQKQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
EK+ +++ +A E LK + E +++K L +E+ RR QE+ +E+ ++L EE +
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQ 2362
Query: 355 RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
+ +RQ+ E ++ + + + EE A+ K ++
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Score = 64.7 bits (156), Expect = 2e-10
Identities = 83/421 (19%), Positives = 182/421 (43%), Gaps = 60/421 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2237
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGEN- 206
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 207 -----------------QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 249
+I+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 250 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 309
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 310 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 368
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2538 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 369 E 369
E
Sbjct: 2596 E 2596
Score = 64.3 bits (155), Expect = 3e-10
Identities = 98/464 (21%), Positives = 188/464 (40%), Gaps = 72/464 (15%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1314
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIE---E 164
E ++ + + T S +S RRM+ E E +++++E R+ E+E E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1370
Query: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD------EKIKKDKE 218
+ AE KE +++ +EE + + ++ Q K +++++ E
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 219 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 278
+ + K+ + ++ + E +L+ R G + A A + EA
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRAR-AEEAEAQ 1488
Query: 279 KRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 336
KR EE R R + + E K + + + A+ E + RE++R + EE R + EEA
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
+R+LR+ E +R + ++ A E Q+ E L +RA
Sbjct: 1549 ERRLRQAEVERARQVQV------ALETAQRSAEAELQ------------------SKRAS 1584
Query: 397 FLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 438
F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/391 (23%), Positives = 168/391 (42%), Gaps = 66/391 (16%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E
Sbjct: 1459 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES----- 1507
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR 229
Q+ + E + E E E++ ++ E +++ E+ ++ E ++ +
Sbjct: 1508 ---QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 230 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE--AGKRLEELRRR 287
T +S E + + E T + E + Q E A +L E R
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHVAVAQLREEAER 1612
Query: 288 RGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVLEEEEQRRKQEE 335
R + ++E ++ ++EA ELE + K E ++K L + E +++EE
Sbjct: 1613 RAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 336 ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
A+R+ R + + +E+ R+R A ++ +K
Sbjct: 1669 AEREAR---RRGKAEEQAVRQRELAEQELEK 1696
Score = 63.9 bits (154), Expect = 3e-10
Identities = 78/385 (20%), Positives = 165/385 (42%), Gaps = 50/385 (12%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ +RQ
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 119 KEFDPT-----ITDASLSLPSRRMQNDTAE-----NETTEKEEKSE-SRQERYEIEETET 167
E + A +S R + D E EK ++E + QE+ + +T
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 168 VTKSYQKND---WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVK 224
+ + +D R+A + +KEK ++E + + S ++ E++ ++ + ++
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ-- 2493
Query: 225 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 284
SF+ K Q F+ + E F +V ++L E
Sbjct: 2494 SFLSEKDSLL----QRERFIEQEKAKLEQLFQ----------------DEVAKAQQLREE 2533
Query: 285 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 344
++R+ + +E ++L +EA E ++ +++ L++ EQ+R+Q+E E
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE----LLAE 2589
Query: 345 EKRRLKEEI----ERRRAEAAEKRQ 365
E +RL+E++ E+ RA A +
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 29.3 bits (64), Expect = 9.5
Identities = 16/70 (22%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ +R+++ Q+R+ RL A +R + EE R ++ +Q +++Q+EE L +
Sbjct: 2532 EEQQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Query: 62 VTDQVEVNAQ 71
++ Q
Sbjct: 2590 ENQRLREQLQ 2599
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/502 (23%), Positives = 219/502 (43%), Gaps = 83/502 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1748
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1749 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A L LA +R+++ +E RQ+ + L+ + T E E KE+++E
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAE 1866
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ----IKD 210
+ + R E+ +++Q+ R EE + K EE + ++ S E + + +
Sbjct: 1867 NERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1918
Query: 211 EKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 266
+ +++ ++ +EE+ SF G E++ + G + + E+T S +
Sbjct: 1919 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDTL------RSKEQ 1968
Query: 267 KEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-ELEELKKKREERRK 322
E E A Q + EE RRR E +S E+ +Q++AAL E+E LK K EE R+
Sbjct: 1969 AELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027
Query: 323 VLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 376
+ E EQ + QE A ++L+ EE+ + + + + ++++ D L +
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 377 KPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 424
+ + + +++ E AE L +S ++ + ++ QAA K+
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEA 2146
Query: 425 EQYTSAIEGTKSAKPTKPAASD 446
EQ + + A + A+D
Sbjct: 2147 EQEAARRAQAEQAALRQKQAAD 2168
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 39/398 (9%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1485 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1544 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1604 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 181 EE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE-------EVKSF 226
+ + +K+KEE E E +RG ++ + ++ +++++K ++ E +
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 227 MDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVEAGKRL 281
+ R + TE Q + + +L + T R A + AE + + R
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778
Query: 282 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQEEADRK 339
EE R E + E + +E A E L+ EE R++ L EE+ R++ EA+R
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 340 LREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 370
L E+ E RLK E E + + E+ +++ ED
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/428 (24%), Positives = 169/428 (39%), Gaps = 46/428 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER R ++ +RL+ E QR + E A R + + RQ QEE +
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEA-LERQKEF 121
Q E + E A + + + A LE L + E ++RL++A +ER ++
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1567
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ A S + + E T + E+S ++E ++ R A+
Sbjct: 1568 QVALETAQRSAEAELQSKRASFAEKTAQLERS--------LQEEHVAVAQLREEAERRAQ 1619
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+ + ++ +EE E E + Q+K + + + EEV + E + +
Sbjct: 1620 QQAEAERAREEAERE------LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EELRRRRGETESEE--- 295
E + E R A + ++ + A +RL +EL R R ETE E
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1733
Query: 296 ---FEKLKQKQQEAAL------ELE-ELKKKREERR-----KVLEEEEQRRKQEEADRKL 340
E+L + Q+EAA ELE EL K R E K EEE R E++ ++L
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793
Query: 341 REEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKPFKCFTPK----GSSLKIE 392
E + R L EE R RA EA +RQ ED + + K G + +++
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853
Query: 393 ERAEFLNK 400
AE K
Sbjct: 1854 TEAEIALK 1861
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/412 (21%), Positives = 168/412 (40%), Gaps = 69/412 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1787 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 170 KSYQKNDWRDAEENK---KEDKEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKE 221
+S ++ + A + + +E++ + E EE K + E + E++++ K E
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023
Query: 222 EVKSFMDR-----------------------KKGFTEVKSQNGEFMTHKLKHTENTFSRP 258
E + +R +K Q + + L+ ++ +
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 259 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 318
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2140
Query: 319 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 363
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2141 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/410 (21%), Positives = 175/410 (42%), Gaps = 27/410 (6%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
+ +++ + K E E +R + E ++ +++ ++ K + + + +
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRD 2262
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
K F+ + + + + R SV +EA Q+ E+L ++R
Sbjct: 2263 KDNTQRFLQEEAEKMKQV-AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA----- 2312
Query: 297 EKLKQKQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
EK+ +++ +A E LK + E +++K L +E+ RR QE+ +E+ ++L EE +
Sbjct: 2313 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQ 2366
Query: 355 RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
+ +RQ+ E ++ + + + EE A+ K ++
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416
Score = 64.7 bits (156), Expect = 2e-10
Identities = 83/421 (19%), Positives = 182/421 (43%), Gaps = 60/421 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2241
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGEN- 206
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 207 -----------------QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 249
+I+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2481
Query: 250 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 309
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2541
Query: 310 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 368
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2542 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 369 E 369
E
Sbjct: 2600 E 2600
Score = 64.3 bits (155), Expect = 3e-10
Identities = 98/464 (21%), Positives = 188/464 (40%), Gaps = 72/464 (15%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1262 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1318
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIE---E 164
E ++ + + T S +S RRM+ E E +++++E R+ E+E E
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1374
Query: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD------EKIKKDKE 218
+ AE KE +++ +EE + + ++ Q K +++++ E
Sbjct: 1375 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434
Query: 219 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 278
+ + K+ + ++ + E +L+ R G + A A + EA
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRAR-AEEAEAQ 1492
Query: 279 KRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 336
KR EE R R + + E K + + + A+ E + RE++R + EE R + EEA
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
+R+LR+ E +R + ++ A E Q+ E L +RA
Sbjct: 1553 ERRLRQAEVERARQVQV------ALETAQRSAEAELQ------------------SKRAS 1588
Query: 397 FLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 438
F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/391 (23%), Positives = 168/391 (42%), Gaps = 66/391 (16%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E
Sbjct: 1463 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES----- 1511
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR 229
Q+ + E + E E E++ ++ E +++ E+ ++ E ++ +
Sbjct: 1512 ---QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1568
Query: 230 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE--AGKRLEELRRR 287
T +S E + + E T + E + Q E A +L E R
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHVAVAQLREEAER 1616
Query: 288 RGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVLEEEEQRRKQEE 335
R + ++E ++ ++EA ELE + K E ++K L + E +++EE
Sbjct: 1617 RAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Query: 336 ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
A+R+ R + + +E+ R+R A ++ +K
Sbjct: 1673 AEREAR---RRGKAEEQAVRQRELAEQELEK 1700
Score = 63.9 bits (154), Expect = 3e-10
Identities = 78/385 (20%), Positives = 165/385 (42%), Gaps = 50/385 (12%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2319
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ +RQ
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 119 KEFDPT-----ITDASLSLPSRRMQNDTAE-----NETTEKEEKSE-SRQERYEIEETET 167
E + A +S R + D E EK ++E + QE+ + +T
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439
Query: 168 VTKSYQKND---WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVK 224
+ + +D R+A + +KEK ++E + + S ++ E++ ++ + ++
Sbjct: 2440 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ-- 2497
Query: 225 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 284
SF+ K Q F+ + E F +V ++L E
Sbjct: 2498 SFLSEKDSLL----QRERFIEQEKAKLEQLFQ----------------DEVAKAQQLREE 2537
Query: 285 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 344
++R+ + +E ++L +EA E ++ +++ L++ EQ+R+Q+E E
Sbjct: 2538 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE----LLAE 2593
Query: 345 EKRRLKEEI----ERRRAEAAEKRQ 365
E +RL+E++ E+ RA A +
Sbjct: 2594 ENQRLREQLQLLEEQHRAALAHSEE 2618
Score = 29.3 bits (64), Expect = 9.5
Identities = 16/70 (22%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ +R+++ Q+R+ RL A +R + EE R ++ +Q +++Q+EE L +
Sbjct: 2536 EEQQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2593
Query: 62 VTDQVEVNAQ 71
++ Q
Sbjct: 2594 ENQRLREQLQ 2603
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/502 (23%), Positives = 219/502 (43%), Gaps = 83/502 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1745 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A L LA +R+++ +E RQ+ + L+ + T E E KE+++E
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAE 1862
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ----IKD 210
+ + R E+ +++Q+ R EE + K EE + ++ S E + + +
Sbjct: 1863 NERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 211 EKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 266
+ +++ ++ +EE+ SF G E++ + G + + E+T S +
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDTL------RSKEQ 1964
Query: 267 KEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-ELEELKKKREERRK 322
E E A Q + EE RRR E +S E+ +Q++AAL E+E LK K EE R+
Sbjct: 1965 AELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 323 VLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 376
+ E EQ + QE A ++L+ EE+ + + + + ++++ D L +
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 377 KPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 424
+ + + +++ E AE L +S ++ + ++ QAA K+
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEA 2142
Query: 425 EQYTSAIEGTKSAKPTKPAASD 446
EQ + + A + A+D
Sbjct: 2143 EQEAARRAQAEQAALRQKQAAD 2164
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 39/398 (9%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1481 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1600 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 181 EE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE-------EVKSF 226
+ + +K+KEE E E +RG ++ + ++ +++++K ++ E +
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 227 MDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVEAGKRL 281
+ R + TE Q + + +L + T R A + AE + + R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 282 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQEEADRK 339
EE R E + E + +E A E L+ EE R++ L EE+ R++ EA+R
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 340 LREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 370
L E+ E RLK E E + + E+ +++ ED
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/428 (24%), Positives = 169/428 (39%), Gaps = 46/428 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER R ++ +RL+ E QR + E A R + + RQ QEE +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEA-LERQKEF 121
Q E + E A + + + A LE L + E ++RL++A +ER ++
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ A S + + E T + E+S ++E ++ R A+
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLERS--------LQEEHVAVAQLREEAERRAQ 1615
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+ + ++ +EE E E + Q+K + + + EEV + E + +
Sbjct: 1616 QQAEAERAREEAERE------LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EELRRRRGETESEE--- 295
E + E R A + ++ + A +RL +EL R R ETE E
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 296 ---FEKLKQKQQEAAL------ELE-ELKKKREERR-----KVLEEEEQRRKQEEADRKL 340
E+L + Q+EAA ELE EL K R E K EEE R E++ ++L
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 341 REEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKPFKCFTPK----GSSLKIE 392
E + R L EE R RA EA +RQ ED + + K G + +++
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 393 ERAEFLNK 400
AE K
Sbjct: 1850 TEAEIALK 1857
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/412 (21%), Positives = 168/412 (40%), Gaps = 69/412 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1783 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 170 KSYQKNDWRDAEENK---KEDKEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKE 221
+S ++ + A + + +E++ + E EE K + E + E++++ K E
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 222 EVKSFMDR-----------------------KKGFTEVKSQNGEFMTHKLKHTENTFSRP 258
E + +R +K Q + + L+ ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 259 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 318
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 319 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 363
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2137 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/410 (21%), Positives = 175/410 (42%), Gaps = 27/410 (6%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
+ +++ + K E E +R + E ++ +++ ++ K + + + +
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
K F+ + + + + R SV +EA Q+ E+L ++R
Sbjct: 2259 KDNTQRFLQEEAEKMKQV-AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA----- 2308
Query: 297 EKLKQKQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
EK+ +++ +A E LK + E +++K L +E+ RR QE+ +E+ ++L EE +
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQ 2362
Query: 355 RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
+ +RQ+ E ++ + + + EE A+ K ++
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Score = 64.7 bits (156), Expect = 2e-10
Identities = 83/421 (19%), Positives = 182/421 (43%), Gaps = 60/421 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2237
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGEN- 206
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 207 -----------------QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 249
+I+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 250 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 309
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 310 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 368
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2538 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 369 E 369
E
Sbjct: 2596 E 2596
Score = 64.3 bits (155), Expect = 3e-10
Identities = 98/464 (21%), Positives = 188/464 (40%), Gaps = 72/464 (15%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1314
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIE---E 164
E ++ + + T S +S RRM+ E E +++++E R+ E+E E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1370
Query: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD------EKIKKDKE 218
+ AE KE +++ +EE + + ++ Q K +++++ E
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 219 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 278
+ + K+ + ++ + E +L+ R G + A A + EA
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRAR-AEEAEAQ 1488
Query: 279 KRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 336
KR EE R R + + E K + + + A+ E + RE++R + EE R + EEA
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
+R+LR+ E +R + ++ A E Q+ E L +RA
Sbjct: 1549 ERRLRQAEVERARQVQV------ALETAQRSAEAELQ------------------SKRAS 1584
Query: 397 FLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 438
F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/391 (23%), Positives = 168/391 (42%), Gaps = 66/391 (16%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E
Sbjct: 1459 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES----- 1507
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR 229
Q+ + E + E E E++ ++ E +++ E+ ++ E ++ +
Sbjct: 1508 ---QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 230 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE--AGKRLEELRRR 287
T +S E + + E T + E + Q E A +L E R
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHVAVAQLREEAER 1612
Query: 288 RGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVLEEEEQRRKQEE 335
R + ++E ++ ++EA ELE + K E ++K L + E +++EE
Sbjct: 1613 RAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 336 ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
A+R+ R + + +E+ R+R A ++ +K
Sbjct: 1669 AEREAR---RRGKAEEQAVRQRELAEQELEK 1696
Score = 63.9 bits (154), Expect = 3e-10
Identities = 78/385 (20%), Positives = 165/385 (42%), Gaps = 50/385 (12%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ +RQ
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 119 KEFDPT-----ITDASLSLPSRRMQNDTAE-----NETTEKEEKSE-SRQERYEIEETET 167
E + A +S R + D E EK ++E + QE+ + +T
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 168 VTKSYQKND---WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVK 224
+ + +D R+A + +KEK ++E + + S ++ E++ ++ + ++
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ-- 2493
Query: 225 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 284
SF+ K Q F+ + E F +V ++L E
Sbjct: 2494 SFLSEKDSLL----QRERFIEQEKAKLEQLFQ----------------DEVAKAQQLREE 2533
Query: 285 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 344
++R+ + +E ++L +EA E ++ +++ L++ EQ+R+Q+E E
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE----LLAE 2589
Query: 345 EKRRLKEEI----ERRRAEAAEKRQ 365
E +RL+E++ E+ RA A +
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 29.3 bits (64), Expect = 9.5
Identities = 16/70 (22%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ +R+++ Q+R+ RL A +R + EE R ++ +Q +++Q+EE L +
Sbjct: 2532 EEQQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Query: 62 VTDQVEVNAQ 71
++ Q
Sbjct: 2590 ENQRLREQLQ 2599
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/502 (23%), Positives = 219/502 (43%), Gaps = 83/502 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1712
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1713 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A L LA +R+++ +E RQ+ + L+ + T E E KE+++E
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAE 1830
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ----IKD 210
+ + R E+ +++Q+ R EE + K EE + ++ S E + + +
Sbjct: 1831 NERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1882
Query: 211 EKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 266
+ +++ ++ +EE+ SF G E++ + G + + E+T S +
Sbjct: 1883 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDTL------RSKEQ 1932
Query: 267 KEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-ELEELKKKREERRK 322
E E A Q + EE RRR E +S E+ +Q++AAL E+E LK K EE R+
Sbjct: 1933 AELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991
Query: 323 VLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 376
+ E EQ + QE A ++L+ EE+ + + + + ++++ D L +
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 377 KPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 424
+ + + +++ E AE L +S ++ + ++ QAA K+
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEA 2110
Query: 425 EQYTSAIEGTKSAKPTKPAASD 446
EQ + + A + A+D
Sbjct: 2111 EQEAARRAQAEQAALRQKQAAD 2132
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 39/398 (9%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1449 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1508 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1568 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 181 EE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE-------EVKSF 226
+ + +K+KEE E E +RG ++ + ++ +++++K ++ E +
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 227 MDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVEAGKRL 281
+ R + TE Q + + +L + T R A + AE + + R
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1742
Query: 282 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQEEADRK 339
EE R E + E + +E A E L+ EE R++ L EE+ R++ EA+R
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 340 LREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 370
L E+ E RLK E E + + E+ +++ ED
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/428 (24%), Positives = 169/428 (39%), Gaps = 46/428 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER R ++ +RL+ E QR + E A R + + RQ QEE +
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEA-LERQKEF 121
Q E + E A + + + A LE L + E ++RL++A +ER ++
Sbjct: 1472 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1531
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ A S + + E T + E+S ++E ++ R A+
Sbjct: 1532 QVALETAQRSAEAELQSKRASFAEKTAQLERS--------LQEEHVAVAQLREEAERRAQ 1583
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+ + ++ +EE E E + Q+K + + + EEV + E + +
Sbjct: 1584 QQAEAERAREEAERE------LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EELRRRRGETESEE--- 295
E + E R A + ++ + A +RL +EL R R ETE E
Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1697
Query: 296 ---FEKLKQKQQEAAL------ELE-ELKKKREERR-----KVLEEEEQRRKQEEADRKL 340
E+L + Q+EAA ELE EL K R E K EEE R E++ ++L
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757
Query: 341 REEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKPFKCFTPK----GSSLKIE 392
E + R L EE R RA EA +RQ ED + + K G + +++
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817
Query: 393 ERAEFLNK 400
AE K
Sbjct: 1818 TEAEIALK 1825
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/412 (21%), Positives = 168/412 (40%), Gaps = 69/412 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1751 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 170 KSYQKNDWRDAEENK---KEDKEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKE 221
+S ++ + A + + +E++ + E EE K + E + E++++ K E
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987
Query: 222 EVKSFMDR-----------------------KKGFTEVKSQNGEFMTHKLKHTENTFSRP 258
E + +R +K Q + + L+ ++ +
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 259 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 318
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2104
Query: 319 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 363
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2105 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/410 (21%), Positives = 175/410 (42%), Gaps = 27/410 (6%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
+ +++ + K E E +R + E ++ +++ ++ K + + + +
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRD 2226
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
K F+ + + + + R SV +EA Q+ E+L ++R
Sbjct: 2227 KDNTQRFLQEEAEKMKQV-AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA----- 2276
Query: 297 EKLKQKQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
EK+ +++ +A E LK + E +++K L +E+ RR QE+ +E+ ++L EE +
Sbjct: 2277 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQ 2330
Query: 355 RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
+ +RQ+ E ++ + + + EE A+ K ++
Sbjct: 2331 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380
Score = 64.7 bits (156), Expect = 2e-10
Identities = 83/421 (19%), Positives = 182/421 (43%), Gaps = 60/421 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2205
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGEN- 206
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 207 -----------------QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 249
+I+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2445
Query: 250 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 309
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2505
Query: 310 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 368
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2506 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563
Query: 369 E 369
E
Sbjct: 2564 E 2564
Score = 64.3 bits (155), Expect = 3e-10
Identities = 98/464 (21%), Positives = 188/464 (40%), Gaps = 72/464 (15%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1226 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1282
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIE---E 164
E ++ + + T S +S RRM+ E E +++++E R+ E+E E
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1338
Query: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD------EKIKKDKE 218
+ AE KE +++ +EE + + ++ Q K +++++ E
Sbjct: 1339 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398
Query: 219 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 278
+ + K+ + ++ + E +L+ R G + A A + EA
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRAR-AEEAEAQ 1456
Query: 279 KRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 336
KR EE R R + + E K + + + A+ E + RE++R + EE R + EEA
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
+R+LR+ E +R + ++ A E Q+ E L +RA
Sbjct: 1517 ERRLRQAEVERARQVQV------ALETAQRSAEAELQ------------------SKRAS 1552
Query: 397 FLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 438
F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/391 (23%), Positives = 168/391 (42%), Gaps = 66/391 (16%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E
Sbjct: 1427 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES----- 1475
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR 229
Q+ + E + E E E++ ++ E +++ E+ ++ E ++ +
Sbjct: 1476 ---QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1532
Query: 230 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE--AGKRLEELRRR 287
T +S E + + E T + E + Q E A +L E R
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHVAVAQLREEAER 1580
Query: 288 RGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVLEEEEQRRKQEE 335
R + ++E ++ ++EA ELE + K E ++K L + E +++EE
Sbjct: 1581 RAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Query: 336 ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
A+R+ R + + +E+ R+R A ++ +K
Sbjct: 1637 AEREAR---RRGKAEEQAVRQRELAEQELEK 1664
Score = 63.9 bits (154), Expect = 3e-10
Identities = 78/385 (20%), Positives = 165/385 (42%), Gaps = 50/385 (12%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ +RQ
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 119 KEFDPT-----ITDASLSLPSRRMQNDTAE-----NETTEKEEKSE-SRQERYEIEETET 167
E + A +S R + D E EK ++E + QE+ + +T
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403
Query: 168 VTKSYQKND---WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVK 224
+ + +D R+A + +KEK ++E + + S ++ E++ ++ + ++
Sbjct: 2404 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ-- 2461
Query: 225 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 284
SF+ K Q F+ + E F +V ++L E
Sbjct: 2462 SFLSEKDSLL----QRERFIEQEKAKLEQLFQ----------------DEVAKAQQLREE 2501
Query: 285 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 344
++R+ + +E ++L +EA E ++ +++ L++ EQ+R+Q+E E
Sbjct: 2502 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE----LLAE 2557
Query: 345 EKRRLKEEI----ERRRAEAAEKRQ 365
E +RL+E++ E+ RA A +
Sbjct: 2558 ENQRLREQLQLLEEQHRAALAHSEE 2582
Score = 29.3 bits (64), Expect = 9.5
Identities = 16/70 (22%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ +R+++ Q+R+ RL A +R + EE R ++ +Q +++Q+EE L +
Sbjct: 2500 EEQQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2557
Query: 62 VTDQVEVNAQ 71
++ Q
Sbjct: 2558 ENQRLREQLQ 2567
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/502 (23%), Positives = 219/502 (43%), Gaps = 83/502 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1881
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1882 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A L LA +R+++ +E RQ+ + L+ + T E E KE+++E
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAE 1999
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ----IKD 210
+ + R E+ +++Q+ R EE + K EE + ++ S E + + +
Sbjct: 2000 NERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 2051
Query: 211 EKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 266
+ +++ ++ +EE+ SF G E++ + G + + E+T S +
Sbjct: 2052 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDTL------RSKEQ 2101
Query: 267 KEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-ELEELKKKREERRK 322
E E A Q + EE RRR E +S E+ +Q++AAL E+E LK K EE R+
Sbjct: 2102 AELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160
Query: 323 VLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 376
+ E EQ + QE A ++L+ EE+ + + + + ++++ D L +
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 377 KPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 424
+ + + +++ E AE L +S ++ + ++ QAA K+
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEA 2279
Query: 425 EQYTSAIEGTKSAKPTKPAASD 446
EQ + + A + A+D
Sbjct: 2280 EQEAARRAQAEQAALRQKQAAD 2301
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 39/398 (9%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1618 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1677 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1737 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 181 EE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE-------EVKSF 226
+ + +K+KEE E E +RG ++ + ++ +++++K ++ E +
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 227 MDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVEAGKRL 281
+ R + TE Q + + +L + T R A + AE + + R
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911
Query: 282 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQEEADRK 339
EE R E + E + +E A E L+ EE R++ L EE+ R++ EA+R
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 340 LREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 370
L E+ E RLK E E + + E+ +++ ED
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/428 (24%), Positives = 169/428 (39%), Gaps = 46/428 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER R ++ +RL+ E QR + E A R + + RQ QEE +
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEA-LERQKEF 121
Q E + E A + + + A LE L + E ++RL++A +ER ++
Sbjct: 1641 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1700
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ A S + + E T + E+S ++E ++ R A+
Sbjct: 1701 QVALETAQRSAEAELQSKRASFAEKTAQLERS--------LQEEHVAVAQLREEAERRAQ 1752
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+ + ++ +EE E E + Q+K + + + EEV + E + +
Sbjct: 1753 QQAEAERAREEAERE------LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EELRRRRGETESEE--- 295
E + E R A + ++ + A +RL +EL R R ETE E
Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1866
Query: 296 ---FEKLKQKQQEAAL------ELE-ELKKKREERR-----KVLEEEEQRRKQEEADRKL 340
E+L + Q+EAA ELE EL K R E K EEE R E++ ++L
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926
Query: 341 REEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKPFKCFTPK----GSSLKIE 392
E + R L EE R RA EA +RQ ED + + K G + +++
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986
Query: 393 ERAEFLNK 400
AE K
Sbjct: 1987 TEAEIALK 1994
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/412 (21%), Positives = 168/412 (40%), Gaps = 69/412 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1920 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 170 KSYQKNDWRDAEENK---KEDKEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKE 221
+S ++ + A + + +E++ + E EE K + E + E++++ K E
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156
Query: 222 EVKSFMDR-----------------------KKGFTEVKSQNGEFMTHKLKHTENTFSRP 258
E + +R +K Q + + L+ ++ +
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 259 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 318
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2273
Query: 319 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 363
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2274 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/410 (21%), Positives = 175/410 (42%), Gaps = 27/410 (6%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
+ +++ + K E E +R + E ++ +++ ++ K + + + +
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRD 2395
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
K F+ + + + + R SV +EA Q+ E+L ++R
Sbjct: 2396 KDNTQRFLQEEAEKMKQV-AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA----- 2445
Query: 297 EKLKQKQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
EK+ +++ +A E LK + E +++K L +E+ RR QE+ +E+ ++L EE +
Sbjct: 2446 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQ 2499
Query: 355 RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
+ +RQ+ E ++ + + + EE A+ K ++
Sbjct: 2500 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549
Score = 64.7 bits (156), Expect = 2e-10
Identities = 83/421 (19%), Positives = 182/421 (43%), Gaps = 60/421 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2374
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGEN- 206
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 207 -----------------QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 249
+I+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2555 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2614
Query: 250 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 309
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2674
Query: 310 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 368
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2675 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732
Query: 369 E 369
E
Sbjct: 2733 E 2733
Score = 64.3 bits (155), Expect = 3e-10
Identities = 98/464 (21%), Positives = 188/464 (40%), Gaps = 72/464 (15%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1395 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1451
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIE---E 164
E ++ + + T S +S RRM+ E E +++++E R+ E+E E
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1507
Query: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD------EKIKKDKE 218
+ AE KE +++ +EE + + ++ Q K +++++ E
Sbjct: 1508 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567
Query: 219 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 278
+ + K+ + ++ + E +L+ R G + A A + EA
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRAR-AEEAEAQ 1625
Query: 279 KRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 336
KR EE R R + + E K + + + A+ E + RE++R + EE R + EEA
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
+R+LR+ E +R + ++ A E Q+ E L +RA
Sbjct: 1686 ERRLRQAEVERARQVQV------ALETAQRSAEAELQ------------------SKRAS 1721
Query: 397 FLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 438
F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/391 (23%), Positives = 168/391 (42%), Gaps = 66/391 (16%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E
Sbjct: 1596 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES----- 1644
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR 229
Q+ + E + E E E++ ++ E +++ E+ ++ E ++ +
Sbjct: 1645 ---QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1701
Query: 230 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE--AGKRLEELRRR 287
T +S E + + E T + E + Q E A +L E R
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHVAVAQLREEAER 1749
Query: 288 RGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVLEEEEQRRKQEE 335
R + ++E ++ ++EA ELE + K E ++K L + E +++EE
Sbjct: 1750 RAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Query: 336 ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
A+R+ R + + +E+ R+R A ++ +K
Sbjct: 1806 AEREAR---RRGKAEEQAVRQRELAEQELEK 1833
Score = 63.9 bits (154), Expect = 3e-10
Identities = 78/385 (20%), Positives = 165/385 (42%), Gaps = 50/385 (12%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2452
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ +RQ
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512
Query: 119 KEFDPT-----ITDASLSLPSRRMQNDTAE-----NETTEKEEKSE-SRQERYEIEETET 167
E + A +S R + D E EK ++E + QE+ + +T
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2572
Query: 168 VTKSYQKND---WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVK 224
+ + +D R+A + +KEK ++E + + S ++ E++ ++ + ++
Sbjct: 2573 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ-- 2630
Query: 225 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 284
SF+ K Q F+ + E F +V ++L E
Sbjct: 2631 SFLSEKDSLL----QRERFIEQEKAKLEQLFQ----------------DEVAKAQQLREE 2670
Query: 285 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 344
++R+ + +E ++L +EA E ++ +++ L++ EQ+R+Q+E E
Sbjct: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE----LLAE 2726
Query: 345 EKRRLKEEI----ERRRAEAAEKRQ 365
E +RL+E++ E+ RA A +
Sbjct: 2727 ENQRLREQLQLLEEQHRAALAHSEE 2751
Score = 29.3 bits (64), Expect = 9.5
Identities = 16/70 (22%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ +R+++ Q+R+ RL A +R + EE R ++ +Q +++Q+EE L +
Sbjct: 2669 EEQQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2726
Query: 62 VTDQVEVNAQ 71
++ Q
Sbjct: 2727 ENQRLREQLQ 2736
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/502 (23%), Positives = 219/502 (43%), Gaps = 83/502 (16%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDD--------------------EEEAARERRRRA 45
R+REL Q+ E+ R AE A QR + EEE AR +R A
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1722
Query: 46 RQERLRQKQEEESLGQVTDQVEV-NAQNSVPDEEAKTTTTNTQV----------EGDDEA 94
+ RQ+ E E L +V ++EV A + +EE+++T+ ++ E +EA
Sbjct: 1723 AATQKRQELEAE-LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 95 AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154
A L LA +R+++ +E RQ+ + L+ + T E E KE+++E
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAE 1840
Query: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ----IKD 210
+ + R E+ +++Q+ R EE + K EE + ++ S E + + +
Sbjct: 1841 NERLRRLAED-----EAFQR---RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE 1892
Query: 211 EKIKKDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDT 266
+ +++ ++ +EE+ SF G E++ + G + + E+T S +
Sbjct: 1893 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS----NAEDTL------RSKEQ 1942
Query: 267 KEAEGAPQVEAGKRLEELRRRRGE---TESEEFEKLKQKQQEAAL-ELEELKKKREERRK 322
E E A Q + EE RRR E +S E+ +Q++AAL E+E LK K EE R+
Sbjct: 1943 AELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001
Query: 323 VLEEEEQ------RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 376
+ E EQ + QE A ++L+ EE+ + + + + ++++ D L +
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 377 KPFKCFTPKGSSLKIE------------ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 424
+ + + +++ E AE L +S ++ + ++ QAA K+
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA-AEKLRKEA 2120
Query: 425 EQYTSAIEGTKSAKPTKPAASD 446
EQ + + A + A+D
Sbjct: 2121 EQEAARRAQAEQAALRQKQAAD 2142
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 39/398 (9%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARE----RRRRARQERLRQKQEE-ESLG 60
R E QKR+ EAER+ Q D+ + + E R +A E R+KQ ++L
Sbjct: 1459 RAEEAEAQKRQAQE-EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517
Query: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
++ Q E + E + +E +A E ++R +K Q Q+E
Sbjct: 1518 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577
Query: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
+ A L + R AE E +E +E ER++++ E + Q +
Sbjct: 1578 H---VAVAQLREEAERRAQQQAEAERAREE--AERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 181 EE--NKKEDKEKEEEEEEKPKRG-----SIGENQIKDEKIKKDKEPKE-------EVKSF 226
+ + +K+KEE E E +RG ++ + ++ +++++K ++ E +
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 227 MDRKKGFTEVKSQNGEFMTHKLKHTEN-----TFSRPGGRASVDTKEAEGAPQVEAGKRL 281
+ R + TE Q + + +L + T R A + AE + + R
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
Query: 282 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE--RRKVLEEEEQRRKQEEADRK 339
EE R E + E + +E A E L+ EE R++ L EE+ R++ EA+R
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 340 LREE----EEKRRLKEEIE---RRRAEAAEKRQKMPED 370
L E+ E RLK E E + + E+ +++ ED
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/428 (24%), Positives = 169/428 (39%), Gaps = 46/428 (10%)
Query: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
ER R ++ +RL+ E QR + E A R + + RQ QEE +
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
Query: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAF--LERLARREERRQKRLQEA-LERQKEF 121
Q E + E A + + + A LE L + E ++RL++A +ER ++
Sbjct: 1482 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1541
Query: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
+ A S + + E T + E+S ++E ++ R A+
Sbjct: 1542 QVALETAQRSAEAELQSKRASFAEKTAQLERS--------LQEEHVAVAQLREEAERRAQ 1593
Query: 182 ENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 241
+ + ++ +EE E E + Q+K + + + EEV + E + +
Sbjct: 1594 QQAEAERAREEAERE------LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
Query: 242 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRL---EELRRRRGETESEE--- 295
E + E R A + ++ + A +RL +EL R R ETE E
Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1707
Query: 296 ---FEKLKQKQQEAAL------ELE-ELKKKREERR-----KVLEEEEQRRKQEEADRKL 340
E+L + Q+EAA ELE EL K R E K EEE R E++ ++L
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767
Query: 341 REEEEK-RRLKEEIERRRA---EAAEKRQKMPEDGLSDDKKPFKCFTPK----GSSLKIE 392
E + R L EE R RA EA +RQ ED + + K G + +++
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827
Query: 393 ERAEFLNK 400
AE K
Sbjct: 1828 TEAEIALK 1835
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/412 (21%), Positives = 168/412 (40%), Gaps = 69/412 (16%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNS 73
++ + RLEAE ++ + EEAAR R +R RQ EE++ Q + V A+
Sbjct: 1761 EKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 74 VPDEEAKTTTTNTQV---EGDDEAAFLERLARREERRQKRLQE-ALERQKEFDPTI---- 125
EA T ++ E + E L RLA E +++RL+E A + + + + +
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 126 --TDASLSLPSRRMQNDTAENETTEKE--------EKSESRQERYEIE------ETETVT 169
+D+ L +++ + E+E EK+ + + E+E E
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 170 KSYQKNDWRDAEENK---KEDKEKEEEEEEKPKRGSIGENQIKD-----EKIKKDKEPKE 221
+S ++ + A + + +E++ + E EE K + E + E++++ K E
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997
Query: 222 EVKSFMDR-----------------------KKGFTEVKSQNGEFMTHKLKHTENTFSRP 258
E + +R +K Q + + L+ ++ +
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 259 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 318
G A + AE A + E + RR + EE E+LKQ +E A + + E
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRR---QVEEAERLKQSAEEQAQARAQAQAAAE 2114
Query: 319 ERRKVLEEEEQRRKQEEADRKLR-------EEEEKRRLKEEIERRRAEAAEK 363
+ RK E+E RR Q E LR E E+ ++ E+ R++A+ ++
Sbjct: 2115 KLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/410 (21%), Positives = 175/410 (42%), Gaps = 27/410 (6%)
Query: 5 ERRRELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQV 62
E RR R ++E R L+ + A Q+ EE+A ++ QE + Q+E+S L Q+
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-REERRQKRLQ-----EALE 116
+ E + + EEA+ + + ERL + EE+ Q R Q E L
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
++ E + + R+ Q AE E +K + RQ+ +E T+ ++ D
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRKKGFTEV 236
+ +++ + K E E +R + E ++ +++ ++ K + + + +
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQRSQV-EEELFSVRVQMEELSKLKARIEAENRALILRD 2236
Query: 237 KSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF 296
K F+ + + + + R SV +EA Q+ E+L ++R
Sbjct: 2237 KDNTQRFLQEEAEKMKQV-AEEAARLSVAAQEAARLRQLAE----EDLAQQRALA----- 2286
Query: 297 EKLKQKQQEAALELEELKKKRE--ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 354
EK+ +++ +A E LK + E +++K L +E+ RR QE+ +E+ ++L EE +
Sbjct: 2287 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQLAEETQ 2340
Query: 355 RRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 404
+ +RQ+ E ++ + + + EE A+ K ++
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
Score = 64.7 bits (156), Expect = 2e-10
Identities = 83/421 (19%), Positives = 182/421 (43%), Gaps = 60/421 (14%)
Query: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEE---------EAARERRRRARQERLRQKQEE 56
R++ Q+ +RL+ E +Q+N DEE EAAR+R + +E + +
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ-VEEELFSVRVQM 2215
Query: 57 ESLGQVTDQVEV-----------NAQNSVPDEEAKTTTTNTQVE----GDDEAAFLERLA 101
E L ++ ++E N Q + +E K + EAA L +LA
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 102 RREERRQKRLQEALERQK-----EFDPTITDASLSLPSRRMQNDTAENETTEKE------ 150
+ +Q+ L E + ++K E +A L + + + A +KE
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 151 -EKSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGEN- 206
E+++ Q E E + S + R AE ++ + + +E+ + + + IGE
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 207 -----------------QIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 249
+I+ ++ D E E + ++R+K + +++ + + +++
Sbjct: 2396 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2455
Query: 250 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 309
+ +A + +E ++ + +E+ + + + +E K +Q ++E +
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2515
Query: 310 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE-AAEKRQKMP 368
++++++R+ R V EE RR+Q EA+ +R ++E+ + E+ R++ E AE+ Q++
Sbjct: 2516 QQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 369 E 369
E
Sbjct: 2574 E 2574
Score = 64.3 bits (155), Expect = 3e-10
Identities = 98/464 (21%), Positives = 188/464 (40%), Gaps = 72/464 (15%)
Query: 14 KREEMRLEAERIAYQRNDDDEEEA-ARERRRRARQ-------------ERLRQKQ----E 55
++ E+ ++ Y R D A ++ RRR Q E+LRQ+Q E
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Query: 56 EESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
E G+ ++ + A+ N++ D E + T Q+E A + + + + +Q
Sbjct: 1236 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE---PVASPAKKPKVQSGSESVIQ 1292
Query: 113 EALERQKEFDPTITDAS-----LSLPSRRMQNDTAENETTEKEEKSESRQERYEIE---E 164
E ++ + + T S +S RRM+ E E +++++E R+ E+E E
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALE 1348
Query: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD------EKIKKDKE 218
+ AE KE +++ +EE + + ++ Q K +++++ E
Sbjct: 1349 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408
Query: 219 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 278
+ + K+ + ++ + E +L+ R G + A A + EA
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRAR-AEEAEAQ 1466
Query: 279 KRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 336
KR EE R R + + E K + + + A+ E + RE++R + EE R + EEA
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526
Query: 337 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 396
+R+LR+ E +R + ++ A E Q+ E L +RA
Sbjct: 1527 ERRLRQAEVERARQVQV------ALETAQRSAEAELQ------------------SKRAS 1562
Query: 397 FLNKSVQKSSGVKSTHQAA--IVSKIDSRLEQYTSAIEGTKSAK 438
F K+ Q ++ H A + + + R +Q A + A+
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/391 (23%), Positives = 168/391 (42%), Gaps = 66/391 (16%)
Query: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRR---------RARQER----LRQKQE 55
E R+ EE RL ++ A +R E EAA E++R +A+ ER L+Q+ +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE-----GDDEAAFLERLARREERRQKR 110
EE + + V+ Q EE + +++ E EAA RL EE R R
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 111 LQ-EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVT 169
LQ EA ERQ+ A L + R + + AE + + +E++E + + + E
Sbjct: 1437 LQLEATERQRG------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES----- 1485
Query: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDR 229
Q+ + E + E E E++ ++ E +++ E+ ++ E ++ +
Sbjct: 1486 ---QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1542
Query: 230 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE--AGKRLEELRRR 287
T +S E + + E T + E + Q E A +L E R
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKT------------AQLERSLQEEHVAVAQLREEAER 1590
Query: 288 RGETESEEFEKLKQKQQEAALELEELKKKREE------------RRKVLEEEEQRRKQEE 335
R + ++E ++ ++EA ELE + K E ++K L + E +++EE
Sbjct: 1591 RAQQQAEA----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Query: 336 ADRKLREEEEKRRLKEEIERRRAEAAEKRQK 366
A+R+ R + + +E+ R+R A ++ +K
Sbjct: 1647 AEREAR---RRGKAEEQAVRQRELAEQELEK 1674
Score = 63.9 bits (154), Expect = 3e-10
Identities = 78/385 (20%), Positives = 165/385 (42%), Gaps = 50/385 (12%)
Query: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR----ARQERLRQKQEEES 58
D + + +++ E+M+ AE A R +EAAR R+ A+Q L +K +E
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2293
Query: 59 LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
+ V + + A+ + ++ + + +D+ ++LA + Q+ L+ +RQ
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353
Query: 119 KEFDPT-----ITDASLSLPSRRMQNDTAE-----NETTEKEEKSE-SRQERYEIEETET 167
E + A +S R + D E EK ++E + QE+ + +T
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2413
Query: 168 VTKSYQKND---WRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVK 224
+ + +D R+A + +KEK ++E + + S ++ E++ ++ + ++
Sbjct: 2414 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ-- 2471
Query: 225 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 284
SF+ K Q F+ + E F +V ++L E
Sbjct: 2472 SFLSEKDSLL----QRERFIEQEKAKLEQLFQ----------------DEVAKAQQLREE 2511
Query: 285 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 344
++R+ + +E ++L +EA E ++ +++ L++ EQ+R+Q+E E
Sbjct: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE----LLAE 2567
Query: 345 EKRRLKEEI----ERRRAEAAEKRQ 365
E +RL+E++ E+ RA A +
Sbjct: 2568 ENQRLREQLQLLEEQHRAALAHSEE 2592
Score = 29.3 bits (64), Expect = 9.5
Identities = 16/70 (22%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
++ +R+++ Q+R+ RL A +R + EE R ++ +Q +++Q+EE L +
Sbjct: 2510 EEQQRQQQQMEQERQ--RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2567
Query: 62 VTDQVEVNAQ 71
++ Q
Sbjct: 2568 ENQRLREQLQ 2577
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.122 0.320
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,846,225
Number of Sequences: 37866
Number of extensions: 1247624
Number of successful extensions: 57500
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1215
Number of HSP's successfully gapped in prelim test: 1514
Number of HSP's that attempted gapping in prelim test: 9524
Number of HSP's gapped (non-prelim): 16170
length of query: 538
length of database: 18,247,518
effective HSP length: 107
effective length of query: 431
effective length of database: 14,195,856
effective search space: 6118413936
effective search space used: 6118413936
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.