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Search of human proteins with 4758958
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758958 cAMP-dependent protein kinase, regulatory subunit
alpha 2 [Homo sapiens]
(404 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758958 cAMP-dependent protein kinase, regulatory subunit alp... 805 0.0
gi|47132585 cAMP-dependent protein kinase, regulatory subunit be... 527 e-150
gi|47132583 cAMP-dependent protein kinase, regulatory subunit al... 237 2e-62
gi|47132581 cAMP-dependent protein kinase, regulatory subunit al... 237 2e-62
gi|4506063 cAMP-dependent protein kinase, regulatory subunit alp... 237 2e-62
gi|38257139 protein kinase, cAMP-dependent, regulatory, type I, ... 233 3e-61
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 136 3e-32
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 135 5e-32
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 132 4e-31
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 51 2e-06
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 51 2e-06
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 51 2e-06
gi|148727335 patatin-like phospholipase domain containing 7 isof... 49 1e-05
gi|148727290 patatin-like phospholipase domain containing 7 isof... 49 1e-05
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 48 1e-05
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 48 2e-05
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 46 5e-05
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 46 5e-05
gi|8394343 sperm autoantigenic protein 17 [Homo sapiens] 46 5e-05
gi|116256487 patatin-like phospholipase domain containing 6 [Hom... 41 0.002
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 41 0.002
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 39 0.008
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 39 0.008
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 39 0.008
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 39 0.008
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 38 0.014
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 38 0.019
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 38 0.019
gi|18201890 hypothetical protein LOC140894 [Homo sapiens] 37 0.024
gi|21359920 ropporin [Homo sapiens] 37 0.032
>gi|4758958 cAMP-dependent protein kinase, regulatory subunit alpha
2 [Homo sapiens]
Length = 404
Score = 805 bits (2079), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLG 60
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLG
Sbjct: 1 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLG 60
Query: 61 HPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIH 120
HPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIH
Sbjct: 61 HPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIH 120
Query: 121 PKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIE 180
PKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIE
Sbjct: 121 PKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIE 180
Query: 181 RGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI 240
RGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI
Sbjct: 181 RGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI 240
Query: 241 IVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYI 300
IVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYI
Sbjct: 241 IVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYI 300
Query: 301 IESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCL 360
IESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCL
Sbjct: 301 IESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCL 360
Query: 361 VMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ 404
VMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ
Sbjct: 361 VMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ 404
>gi|47132585 cAMP-dependent protein kinase, regulatory subunit beta
2 [Homo sapiens]
Length = 418
Score = 527 bits (1357), Expect = e-150
Identities = 274/412 (66%), Positives = 322/412 (78%), Gaps = 17/412 (4%)
Query: 4 IQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLRE-------ARAPASVLPAATPR 56
I+IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL++ AR
Sbjct: 3 IEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLG 62
Query: 57 QSLGHPPPEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAETYNP 107
+ G P G + + + DSE E+E+ PV +RF RR SVCAE YNP
Sbjct: 63 AAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNP 122
Query: 108 DEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVI 167
DEEE+D + R+IHPKTD+QR RLQEACKDILLFKNLD EQ+SQVLDAMFE++VK EHVI
Sbjct: 123 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVI 182
Query: 168 DQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEG 227
DQGDDGDNFYVI+RGT+DI V D R VG YDNRGSFGELALMYNTPRAATI ATS G
Sbjct: 183 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPG 242
Query: 228 SLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGER 287
+LWGLDRVTFRRIIVKNNAKKRKM+ESFIES+P LKSLE SER+K+VDVIG K+Y DGE+
Sbjct: 243 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQ 302
Query: 288 IITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPR 347
II QG+ ADSF+I+ESGEV I ++ + KS + N VEIARC +GQYFGELALVTNKPR
Sbjct: 303 IIAQGDSADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYFGELALVTNKPR 361
Query: 348 AASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDL 399
AASA+A+G VKCL MDVQAFERLLGPCM+IMKRNI+ YEEQLV +FG+++D+
Sbjct: 362 AASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI 413
>gi|47132583 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 237 bits (604), Expect = 2e-62
Identities = 144/375 (38%), Positives = 209/375 (55%), Gaps = 33/375 (8%)
Query: 13 LLQGYTVEVLRQQPPDLVEFAVEYFTRLR--EARAPASVLPAATPRQSLGHPPPEPGPDR 70
LL+ V++ +P + F EYF RL EA+ ++ A T S P P+
Sbjct: 30 LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPN- 88
Query: 71 VADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRL 130
PV RR ++ AE Y EE+ + R + PK + L
Sbjct: 89 ------------------PVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAAL 128
Query: 131 QEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTK 190
+A + +LF +LD + S + DAMF A E VI QGD+GDNFYVI++G D+ V
Sbjct: 129 AKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNN 188
Query: 191 DNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK 250
+ T SVG+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KRK
Sbjct: 189 EWAT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 244
Query: 251 MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILI 310
M+E F+ V +L+SL+ ER+ + D + ++DG++I+ QGE D F+II G ++L
Sbjct: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
Query: 311 RSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERL 370
R + + VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 305 R------RSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
Query: 371 LGPCMDIMKRNISHY 385
LGPC DI+KRNI Y
Sbjct: 359 LGPCSDILKRNIQQY 373
>gi|47132581 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 237 bits (604), Expect = 2e-62
Identities = 144/375 (38%), Positives = 209/375 (55%), Gaps = 33/375 (8%)
Query: 13 LLQGYTVEVLRQQPPDLVEFAVEYFTRLR--EARAPASVLPAATPRQSLGHPPPEPGPDR 70
LL+ V++ +P + F EYF RL EA+ ++ A T S P P+
Sbjct: 30 LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPN- 88
Query: 71 VADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRL 130
PV RR ++ AE Y EE+ + R + PK + L
Sbjct: 89 ------------------PVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAAL 128
Query: 131 QEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTK 190
+A + +LF +LD + S + DAMF A E VI QGD+GDNFYVI++G D+ V
Sbjct: 129 AKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNN 188
Query: 191 DNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK 250
+ T SVG+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KRK
Sbjct: 189 EWAT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 244
Query: 251 MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILI 310
M+E F+ V +L+SL+ ER+ + D + ++DG++I+ QGE D F+II G ++L
Sbjct: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
Query: 311 RSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERL 370
R + + VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 305 R------RSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
Query: 371 LGPCMDIMKRNISHY 385
LGPC DI+KRNI Y
Sbjct: 359 LGPCSDILKRNIQQY 373
>gi|4506063 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 237 bits (604), Expect = 2e-62
Identities = 144/375 (38%), Positives = 209/375 (55%), Gaps = 33/375 (8%)
Query: 13 LLQGYTVEVLRQQPPDLVEFAVEYFTRLR--EARAPASVLPAATPRQSLGHPPPEPGPDR 70
LL+ V++ +P + F EYF RL EA+ ++ A T S P P+
Sbjct: 30 LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPN- 88
Query: 71 VADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRL 130
PV RR ++ AE Y EE+ + R + PK + L
Sbjct: 89 ------------------PVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAAL 128
Query: 131 QEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTK 190
+A + +LF +LD + S + DAMF A E VI QGD+GDNFYVI++G D+ V
Sbjct: 129 AKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNN 188
Query: 191 DNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK 250
+ T SVG+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KRK
Sbjct: 189 EWAT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 244
Query: 251 MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILI 310
M+E F+ V +L+SL+ ER+ + D + ++DG++I+ QGE D F+II G ++L
Sbjct: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
Query: 311 RSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERL 370
R + + VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 305 R------RSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
Query: 371 LGPCMDIMKRNISHY 385
LGPC DI+KRNI Y
Sbjct: 359 LGPCSDILKRNIQQY 373
>gi|38257139 protein kinase, cAMP-dependent, regulatory, type I,
beta [Homo sapiens]
Length = 381
Score = 233 bits (593), Expect = 3e-61
Identities = 141/378 (37%), Positives = 209/378 (55%), Gaps = 31/378 (8%)
Query: 9 GLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGP 68
G+ ++L+ V + +P ++F E+F +L + RQ L
Sbjct: 26 GIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEEN----------RQILAR------- 68
Query: 69 DRVADAKGDSESEEDEDLEV-PVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQR 127
+ ++++ DS EE PV RR V AE Y EE+ + R + PK +
Sbjct: 69 -QKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYT--EEDAVSYVRKVIPKDYKTM 125
Query: 128 CRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDIL 187
L +A +LF +LD + S + DAMF A E VI QG++GDNFYV+++G D+
Sbjct: 126 TALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVY 185
Query: 188 VTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAK 247
V + T GSFGELAL+Y TPRAAT+ A ++ LWG+DR ++RRI++ + +
Sbjct: 186 VNGEWVTN----ISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLR 241
Query: 248 KRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVS 307
KRKM+E F+ V +L+SLE ER+ + D + ++DGE+I+ QGE D FYII G S
Sbjct: 242 KRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTAS 301
Query: 308 ILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAF 367
+L R + + VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D F
Sbjct: 302 VLQR------RSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRF 355
Query: 368 ERLLGPCMDIMKRNISHY 385
ER+LGPC +I+KRNI Y
Sbjct: 356 ERVLGPCSEILKRNIQRY 373
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 136 bits (343), Expect = 3e-32
Identities = 90/289 (31%), Positives = 148/289 (51%), Gaps = 18/289 (6%)
Query: 96 RRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAM 155
+R ++ AE D ++ +PK+ + + ++EA D KNL+ Q+ +++D M
Sbjct: 75 KRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCM 134
Query: 156 FERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQ---TRSVGQYDNRGSFGELALM 212
+ D +I +GD G YV+E G + VTK+ T G+ FGELA++
Sbjct: 135 YPVEYGKDSCIIKEGDVGSLVYVMEDGKVE--VTKEGVKLCTMGPGKV-----FGELAIL 187
Query: 213 YNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMK 272
YN R AT+ LW +DR F+ I+++ K + F++SVP +SL K
Sbjct: 188 YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSK 247
Query: 273 IVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQE-VEIARCH 331
+ DV+ E Y++GE II QG + D+F+II G V++ + +D +++ V +
Sbjct: 248 LADVLEETHYENGEYIIRQGARGDTFFIISKGTVNV-------TREDSPSEDPVFLRTLG 300
Query: 332 KGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKR 380
KG +FGE AL R A+ A V CLV+D +F+ L+G D+ +
Sbjct: 301 KGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNK 349
Score = 56.2 bits (134), Expect = 5e-08
Identities = 46/180 (25%), Positives = 88/180 (48%), Gaps = 19/180 (10%)
Query: 132 EACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKD 191
E K + F++L +E LS++ D + E + E++I QG GD F++I +GT + VT++
Sbjct: 229 EFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN--VTRE 286
Query: 192 NQT-------RSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKN 244
+ R++G+ D FGE AL R A ++A + +DR +F+ +I
Sbjct: 287 DSPSEDPVFLRTLGKGD---WFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGL 343
Query: 245 NAKKRKMFE------SFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSF 298
+ K +E + +L++S+ I+D +G + E + + E++ +F
Sbjct: 344 DDVSNKAYEDAEAKAKYEAEAAFFANLKLSD-FNIIDTLGVGGFGRVELVQLKSEESKTF 402
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 135 bits (341), Expect = 5e-32
Identities = 89/325 (27%), Positives = 163/325 (50%), Gaps = 20/325 (6%)
Query: 60 GHPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAE----TYNPDEEEEDTD 115
G P + PD+V E V + SR + V AE TY+ ++ E +
Sbjct: 90 GGSPLQASPDKVP-----LEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSF 144
Query: 116 PRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDN 175
+ K ++ + +A K LD +Q+ +++ M+ R + ++I QG+ G++
Sbjct: 145 EKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNH 204
Query: 176 FYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRV 235
+V+ G ++ + S+ + +FGELA++YN R A++ A + W LDR
Sbjct: 205 IFVLAEGRLEVF-QGEKLLSSIPMWT---TFGELAILYNCTRTASVKAITNVKTWALDRE 260
Query: 236 TFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKA 295
F+ I+ + + + + +F+ SV LLK+L + KI+D + + Y G+ II +GE+
Sbjct: 261 VFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEG 320
Query: 296 DSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYA-V 354
+F+I+ G+V + + +G +Q I KG+YFGE AL+++ R+A+ A
Sbjct: 321 STFFILAKGKVKV------TQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEE 374
Query: 355 GDVKCLVMDVQAFERLLGPCMDIMK 379
DV CLV+D + F + +G ++ K
Sbjct: 375 NDVACLVIDRETFNQTVGTFEELQK 399
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 132 bits (333), Expect = 4e-31
Identities = 85/263 (32%), Positives = 137/263 (52%), Gaps = 18/263 (6%)
Query: 122 KTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIER 181
K++ + ++EA D KNL+ Q+ +++D M+ D +I +GD G YV+E
Sbjct: 86 KSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMED 145
Query: 182 GTYDILVTKDNQ---TRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFR 238
G + VTK+ T G+ FGELA++YN R AT+ LW +DR F+
Sbjct: 146 GKVE--VTKEGVKLCTMGPGKV-----FGELAILYNCTRTATVKTLVNVKLWAIDRQCFQ 198
Query: 239 RIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSF 298
I+++ K + F++SVP +SL K+ DV+ E Y++GE II QG + D+F
Sbjct: 199 TIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTF 258
Query: 299 YIIESGEVSILIRSRTKSNKDGGNQE-VEIARCHKGQYFGELALVTNKPRAASAYAVGDV 357
+II G V++ + +D +++ V + KG +FGE AL R A+ A V
Sbjct: 259 FIISKGTVNV-------TREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAV 311
Query: 358 KCLVMDVQAFERLLGPCMDIMKR 380
CLV+D +F+ L+G D+ +
Sbjct: 312 TCLVIDRDSFKHLIGGLDDVSNK 334
Score = 56.2 bits (134), Expect = 5e-08
Identities = 46/180 (25%), Positives = 88/180 (48%), Gaps = 19/180 (10%)
Query: 132 EACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKD 191
E K + F++L +E LS++ D + E + E++I QG GD F++I +GT + VT++
Sbjct: 214 EFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN--VTRE 271
Query: 192 NQT-------RSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKN 244
+ R++G+ D FGE AL R A ++A + +DR +F+ +I
Sbjct: 272 DSPSEDPVFLRTLGKGD---WFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGL 328
Query: 245 NAKKRKMFE------SFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSF 298
+ K +E + +L++S+ I+D +G + E + + E++ +F
Sbjct: 329 DDVSNKAYEDAEAKAKYEAEAAFFANLKLSD-FNIIDTLGVGGFGRVELVQLKSEESKTF 387
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 51.2 bits (121), Expect = 2e-06
Identities = 40/136 (29%), Positives = 70/136 (51%), Gaps = 9/136 (6%)
Query: 122 KTDEQRCRLQEAC---KDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYV 178
+TDE+ + E K + N + +L+ VL +FE KA + QGD G ++Y+
Sbjct: 186 RTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL--LFEPHSKAGTVLFSQGDKGTSWYI 243
Query: 179 IERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEG-SLWGLDRVTF 237
I +G+ +++ ++ + D+ FG+LAL+ + PRAATI+ + +D+ F
Sbjct: 244 IWKGSVNVVTHGKGLVTTLHEGDD---FGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300
Query: 238 RRIIVKNNAKKRKMFE 253
RII AK ++ E
Sbjct: 301 NRIIKDVEAKTMRLEE 316
Score = 43.9 bits (102), Expect = 3e-04
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 12/90 (13%)
Query: 283 KDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALV 342
K G + +QG+K S+YII G V+++ + + H+G FG+LALV
Sbjct: 226 KAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL-----------VTTLHEGDDFGQLALV 274
Query: 343 TNKPRAASAYAVGD-VKCLVMDVQAFERLL 371
+ PRAA+ D L +D Q F R++
Sbjct: 275 NDAPRAATIILREDNCHFLRVDKQDFNRII 304
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 51.2 bits (121), Expect = 2e-06
Identities = 40/136 (29%), Positives = 70/136 (51%), Gaps = 9/136 (6%)
Query: 122 KTDEQRCRLQEAC---KDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYV 178
+TDE+ + E K + N + +L+ VL +FE KA + QGD G ++Y+
Sbjct: 186 RTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL--LFEPHSKAGTVLFSQGDKGTSWYI 243
Query: 179 IERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEG-SLWGLDRVTF 237
I +G+ +++ ++ + D+ FG+LAL+ + PRAATI+ + +D+ F
Sbjct: 244 IWKGSVNVVTHGKGLVTTLHEGDD---FGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300
Query: 238 RRIIVKNNAKKRKMFE 253
RII AK ++ E
Sbjct: 301 NRIIKDVEAKTMRLEE 316
Score = 43.9 bits (102), Expect = 3e-04
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 12/90 (13%)
Query: 283 KDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALV 342
K G + +QG+K S+YII G V+++ + + H+G FG+LALV
Sbjct: 226 KAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL-----------VTTLHEGDDFGQLALV 274
Query: 343 TNKPRAASAYAVGD-VKCLVMDVQAFERLL 371
+ PRAA+ D L +D Q F R++
Sbjct: 275 NDAPRAATIILREDNCHFLRVDKQDFNRII 304
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 51.2 bits (121), Expect = 2e-06
Identities = 40/136 (29%), Positives = 70/136 (51%), Gaps = 9/136 (6%)
Query: 122 KTDEQRCRLQEAC---KDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYV 178
+TDE+ + E K + N + +L+ VL +FE KA + QGD G ++Y+
Sbjct: 228 RTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL--LFEPHSKAGTVLFSQGDKGTSWYI 285
Query: 179 IERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEG-SLWGLDRVTF 237
I +G+ +++ ++ + D+ FG+LAL+ + PRAATI+ + +D+ F
Sbjct: 286 IWKGSVNVVTHGKGLVTTLHEGDD---FGQLALVNDAPRAATIILREDNCHFLRVDKQDF 342
Query: 238 RRIIVKNNAKKRKMFE 253
RII AK ++ E
Sbjct: 343 NRIIKDVEAKTMRLEE 358
Score = 43.9 bits (102), Expect = 3e-04
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 12/90 (13%)
Query: 283 KDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALV 342
K G + +QG+K S+YII G V+++ + + H+G FG+LALV
Sbjct: 268 KAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL-----------VTTLHEGDDFGQLALV 316
Query: 343 TNKPRAASAYAVGD-VKCLVMDVQAFERLL 371
+ PRAA+ D L +D Q F R++
Sbjct: 317 NDAPRAATIILREDNCHFLRVDKQDFNRII 346
>gi|148727335 patatin-like phospholipase domain containing 7 isoform
a [Homo sapiens]
Length = 1342
Score = 48.5 bits (114), Expect = 1e-05
Identities = 72/328 (21%), Positives = 127/328 (38%), Gaps = 33/328 (10%)
Query: 80 SEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILL 139
S+E V SR + V+ T + E TD + K+D + A KD+L
Sbjct: 431 SDEHPGSSVASKSRKSVMVAEIPSTVS-QHSESHTDETLASRKSD---AIFRAAKKDLLT 486
Query: 140 FKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQ 199
L+ L A+ V A V QGD + + G + K
Sbjct: 487 LMKLEDSSLLDGRVALLH--VPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCL 544
Query: 200 YDNRGS--FGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIE 257
+ R G+LA++ P T+ A + S + + F I+ K + + ++
Sbjct: 545 FLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVK 604
Query: 258 SVPLLKSLEVSERMKIVDVIGEKIYKD-GERIITQGEKADSFYIIESGEVSILIRSRTKS 316
+S ++ +D + + + G I QG+K+D YI+ SG + +IR
Sbjct: 605 --------RMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIR----- 651
Query: 317 NKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMD 376
KD G + + +G G + +T++ RA + +AV D +L +
Sbjct: 652 -KDDGKKRL-AGEYGRGDLVGVVETLTHQARATTVHAVRD--------SELAKLPAGALT 701
Query: 377 IMKRNISHYEEQLVKMFGSSVDLGNLGQ 404
+KR +L+ + G + LG+L Q
Sbjct: 702 SIKRRYPQVVTRLIHLLGEKI-LGSLQQ 728
>gi|148727290 patatin-like phospholipase domain containing 7 isoform
b [Homo sapiens]
Length = 1317
Score = 48.5 bits (114), Expect = 1e-05
Identities = 72/328 (21%), Positives = 127/328 (38%), Gaps = 33/328 (10%)
Query: 80 SEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILL 139
S+E V SR + V+ T + E TD + K+D + A KD+L
Sbjct: 406 SDEHPGSSVASKSRKSVMVAEIPSTVS-QHSESHTDETLASRKSD---AIFRAAKKDLLT 461
Query: 140 FKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQ 199
L+ L A+ V A V QGD + + G + K
Sbjct: 462 LMKLEDSSLLDGRVALLH--VPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCL 519
Query: 200 YDNRGS--FGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIE 257
+ R G+LA++ P T+ A + S + + F I+ K + + ++
Sbjct: 520 FLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVK 579
Query: 258 SVPLLKSLEVSERMKIVDVIGEKIYKD-GERIITQGEKADSFYIIESGEVSILIRSRTKS 316
+S ++ +D + + + G I QG+K+D YI+ SG + +IR
Sbjct: 580 --------RMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIR----- 626
Query: 317 NKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMD 376
KD G + + +G G + +T++ RA + +AV D +L +
Sbjct: 627 -KDDGKKRL-AGEYGRGDLVGVVETLTHQARATTVHAVRD--------SELAKLPAGALT 676
Query: 377 IMKRNISHYEEQLVKMFGSSVDLGNLGQ 404
+KR +L+ + G + LG+L Q
Sbjct: 677 SIKRRYPQVVTRLIHLLGEKI-LGSLQQ 703
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/146 (26%), Positives = 66/146 (45%), Gaps = 18/146 (12%)
Query: 226 EGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDG 285
E S+ G R I+ N +K + S+PL + + + ++ + ++++ G
Sbjct: 566 EESILGELSEPLREEIINFNCRK------LVASMPLFANADPNFVTSMLTKLRFEVFQPG 619
Query: 286 ERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNK 345
+ II +G Y I+ G VS+L + GN+E ++A G YFGE+ L+T
Sbjct: 620 DYIIREGTIGKKMYFIQHGVVSVLTK---------GNKETKLA---DGSYFGEICLLTRG 667
Query: 346 PRAASAYAVGDVKCLVMDVQAFERLL 371
R AS A + + V F +L
Sbjct: 668 RRTASVRADTYCRLYSLSVDNFNEVL 693
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 47.8 bits (112), Expect = 2e-05
Identities = 38/146 (26%), Positives = 67/146 (45%), Gaps = 18/146 (12%)
Query: 226 EGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDG 285
E S+ G R IV N +K + S+PL + + + ++ + ++++ G
Sbjct: 515 EDSILGELNGPLREEIVNFNCRK------LVASMPLFANADPNFVTAMLTKLKFEVFQPG 568
Query: 286 ERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNK 345
+ II +G Y I+ G VS+L + GN+E++++ G YFGE+ L+T
Sbjct: 569 DYIIREGTIGKKMYFIQHGVVSVLTK---------GNKEMKLS---DGSYFGEICLLTRG 616
Query: 346 PRAASAYAVGDVKCLVMDVQAFERLL 371
R AS A + + V F +L
Sbjct: 617 RRTASVRADTYCRLYSLSVDNFNEVL 642
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 46.2 bits (108), Expect = 5e-05
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 13/115 (11%)
Query: 259 VPLLKSLEVSERMKIVDV-IGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSN 317
+ L L + + ++ V I E K G + QGE+ S+YII G V+++I +
Sbjct: 210 IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGV-- 267
Query: 318 KDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGD-VKCLVMDVQAFERLL 371
+ H+G FG+LALV + PRAAS D L +D + F R+L
Sbjct: 268 ---------VCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 313
Score = 45.4 bits (106), Expect = 9e-05
Identities = 52/204 (25%), Positives = 97/204 (47%), Gaps = 38/204 (18%)
Query: 82 EDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDT-----------DPRVIHPKTDEQRC-- 128
+DE + P+P+ ++ DEE +DT R+I K QR
Sbjct: 147 DDEHEDAPLPTEEEKKEC--------DEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVD 198
Query: 129 RLQEACKDILLFKNLD------QEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERG 182
L+ +++L K L + +L+ VL +FE K + +QG++G ++Y+I +G
Sbjct: 199 DLEIIYEELLHIKALSHLSTTVKRELAGVL--IFESHAKGGTVLFNQGEEGTSWYIILKG 256
Query: 183 TYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEG-SLWGLDRVTFRRII 241
+ ++++ ++ + D+ FG+LAL+ + PRAA+IV + +D+ F RI+
Sbjct: 257 SVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 313
Query: 242 --VKNNAKKRKMFES---FIESVP 260
V+ N + K + +E VP
Sbjct: 314 RDVEANTVRLKEHDQDVLVLEKVP 337
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 46.2 bits (108), Expect = 5e-05
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 13/115 (11%)
Query: 259 VPLLKSLEVSERMKIVDV-IGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSN 317
+ L L + + ++ V I E K G + QGE+ S+YII G V+++I +
Sbjct: 354 IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGV-- 411
Query: 318 KDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGD-VKCLVMDVQAFERLL 371
+ H+G FG+LALV + PRAAS D L +D + F R+L
Sbjct: 412 ---------VCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457
Score = 45.4 bits (106), Expect = 9e-05
Identities = 52/204 (25%), Positives = 97/204 (47%), Gaps = 38/204 (18%)
Query: 82 EDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDT-----------DPRVIHPKTDEQRC-- 128
+DE + P+P+ ++ DEE +DT R+I K QR
Sbjct: 291 DDEHEDAPLPTEEEKKEC--------DEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVD 342
Query: 129 RLQEACKDILLFKNLD------QEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERG 182
L+ +++L K L + +L+ VL +FE K + +QG++G ++Y+I +G
Sbjct: 343 DLEIIYEELLHIKALSHLSTTVKRELAGVL--IFESHAKGGTVLFNQGEEGTSWYIILKG 400
Query: 183 TYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEG-SLWGLDRVTFRRII 241
+ ++++ ++ + D+ FG+LAL+ + PRAA+IV + +D+ F RI+
Sbjct: 401 SVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457
Query: 242 --VKNNAKKRKMFES---FIESVP 260
V+ N + K + +E VP
Sbjct: 458 RDVEANTVRLKEHDQDVLVLEKVP 481
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/109 (24%), Positives = 52/109 (47%), Gaps = 4/109 (3%)
Query: 135 KDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQT 194
K++ F+ L Q+ + ++ + QGD G N+Y + G+ D+ V++ +
Sbjct: 39 KEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 98
Query: 195 RSVGQYDNRG---SFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI 240
+ G +FGE +++ NTPR ATIV L +++ F+ +
Sbjct: 99 QDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQKDFKAL 146
>gi|8394343 sperm autoantigenic protein 17 [Homo sapiens]
Length = 151
Score = 46.2 bits (108), Expect = 5e-05
Identities = 30/94 (31%), Positives = 42/94 (44%), Gaps = 5/94 (5%)
Query: 2 SHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPA-----ATPR 56
+H +IP G LL+G T E+LR+QP ++ FA YF L E R + PA R
Sbjct: 8 THYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDR 67
Query: 57 QSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPV 90
H E P +D K + ++ E V
Sbjct: 68 FYNNHAFEEQEPPEKSDPKQEESQISGKEEETSV 101
>gi|116256487 patatin-like phospholipase domain containing 6 [Homo
sapiens]
Length = 1327
Score = 41.2 bits (95), Expect = 0.002
Identities = 69/317 (21%), Positives = 125/317 (39%), Gaps = 28/317 (8%)
Query: 91 PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQ 150
P++ R A Y+ E+E T P Q + EA K L K + E S
Sbjct: 417 PTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELA-KLMRIEDPSL 475
Query: 151 VLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGS--FGE 208
+ + KA + QGD + + + G + ++ V + + G+
Sbjct: 476 LNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQ 535
Query: 209 LALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVS 268
LA++ P T+ A + TF RI + + + S + S + +S
Sbjct: 536 LAVLTGEPLIFTLRAQRD--------CTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMS 587
Query: 269 ERMKIVD-VIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEI 327
++ +D I + G + QG+++D YI+ +G R R+ + G +E+ +
Sbjct: 588 PFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNG------RLRSVIQRGSGKKEL-V 640
Query: 328 ARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEE 387
+G G + +T +PRA + +AV D + + E LG +KR
Sbjct: 641 GEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLP----EGTLGH----IKRRYPQVVT 692
Query: 388 QLVKMFGSSVDLGNLGQ 404
+L+ + + LGNL Q
Sbjct: 693 RLIHLLSQKI-LGNLQQ 708
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 40.8 bits (94), Expect = 0.002
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 18/134 (13%)
Query: 238 RRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADS 297
R IV N +K + ++PL + + + ++ + ++++ G+ II +G
Sbjct: 458 REEIVNFNCRK------LVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKK 511
Query: 298 FYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDV 357
Y I+ G ++ TKS+K+ + G YFGE+ L+T R AS A
Sbjct: 512 MYFIQHGVAGVI----TKSSKE--------MKLTDGSYFGEICLLTKGRRTASVRADTYC 559
Query: 358 KCLVMDVQAFERLL 371
+ + V F +L
Sbjct: 560 RLYSLSVDNFNEVL 573
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.9 bits (89), Expect = 0.008
Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 15/122 (12%)
Query: 55 PRQSLGHPPPEPGPDRVADAKGDSESEEDEDL---EVPVPSRFNRRVSVCAETYNPDEEE 111
P++ + P + + ++E E+ED EVP S + S ET P+ EE
Sbjct: 1213 PKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEE 1272
Query: 112 EDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGD 171
E+ PRV ++EQR +E + L++ + + DA E + D+H D D
Sbjct: 1273 EEEKPRV----SEEQRQSEEEQ-------QELEEPEPEEEEDAAAE-TAQNDDHDADDED 1320
Query: 172 DG 173
DG
Sbjct: 1321 DG 1322
Score = 33.5 bits (75), Expect = 0.35
Identities = 33/140 (23%), Positives = 56/140 (40%), Gaps = 13/140 (9%)
Query: 42 EARAPASVLPAATPRQSLGHP---------PPEPGPDRVADAKGDSESEEDEDLEVPVPS 92
E A +S +PAA+P S P E RV++ + SE EE ++LE P P
Sbjct: 1241 EEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSE-EEQQELEEPEP- 1298
Query: 93 RFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVL 152
AET D+ + D + T ++ Q +D+ + + L +
Sbjct: 1299 --EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANM 1356
Query: 153 DAMFERIVKADEHVIDQGDD 172
E+I +E +D ++
Sbjct: 1357 QKSREKIKDKEETELDSEEE 1376
Score = 30.4 bits (67), Expect = 3.0
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 10/85 (11%)
Query: 79 ESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEA--CKD 136
E ED D E P+P T+ DEEEE+ D + P+ +R Q+ C+
Sbjct: 1047 EPFEDSDSERPMPR--------LEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQS 1098
Query: 137 ILLFKNLDQEQLSQVLDAMFERIVK 161
K+ D+E+ + DA I+K
Sbjct: 1099 SSKRKSKDEEEDEESDDADDTPILK 1123
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.9 bits (89), Expect = 0.008
Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 15/122 (12%)
Query: 55 PRQSLGHPPPEPGPDRVADAKGDSESEEDEDL---EVPVPSRFNRRVSVCAETYNPDEEE 111
P++ + P + + ++E E+ED EVP S + S ET P+ EE
Sbjct: 1213 PKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEE 1272
Query: 112 EDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGD 171
E+ PRV ++EQR +E + L++ + + DA E + D+H D D
Sbjct: 1273 EEEKPRV----SEEQRQSEEEQ-------QELEEPEPEEEEDAAAE-TAQNDDHDADDED 1320
Query: 172 DG 173
DG
Sbjct: 1321 DG 1322
Score = 33.5 bits (75), Expect = 0.35
Identities = 33/140 (23%), Positives = 56/140 (40%), Gaps = 13/140 (9%)
Query: 42 EARAPASVLPAATPRQSLGHP---------PPEPGPDRVADAKGDSESEEDEDLEVPVPS 92
E A +S +PAA+P S P E RV++ + SE EE ++LE P P
Sbjct: 1241 EEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSE-EEQQELEEPEP- 1298
Query: 93 RFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVL 152
AET D+ + D + T ++ Q +D+ + + L +
Sbjct: 1299 --EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANM 1356
Query: 153 DAMFERIVKADEHVIDQGDD 172
E+I +E +D ++
Sbjct: 1357 QKSREKIKDKEETELDSEEE 1376
Score = 30.4 bits (67), Expect = 3.0
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 10/85 (11%)
Query: 79 ESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEA--CKD 136
E ED D E P+P T+ DEEEE+ D + P+ +R Q+ C+
Sbjct: 1047 EPFEDSDSERPMPR--------LEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQS 1098
Query: 137 ILLFKNLDQEQLSQVLDAMFERIVK 161
K+ D+E+ + DA I+K
Sbjct: 1099 SSKRKSKDEEEDEESDDADDTPILK 1123
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 38.9 bits (89), Expect = 0.008
Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 15/122 (12%)
Query: 55 PRQSLGHPPPEPGPDRVADAKGDSESEEDEDL---EVPVPSRFNRRVSVCAETYNPDEEE 111
P++ + P + + ++E E+ED EVP S + S ET P+ EE
Sbjct: 1213 PKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEE 1272
Query: 112 EDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGD 171
E+ PRV ++EQR +E + L++ + + DA E + D+H D D
Sbjct: 1273 EEEKPRV----SEEQRQSEEEQ-------QELEEPEPEEEEDAAAE-TAQNDDHDADDED 1320
Query: 172 DG 173
DG
Sbjct: 1321 DG 1322
Score = 33.5 bits (75), Expect = 0.35
Identities = 33/140 (23%), Positives = 56/140 (40%), Gaps = 13/140 (9%)
Query: 42 EARAPASVLPAATPRQSLGHP---------PPEPGPDRVADAKGDSESEEDEDLEVPVPS 92
E A +S +PAA+P S P E RV++ + SE EE ++LE P P
Sbjct: 1241 EEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSE-EEQQELEEPEP- 1298
Query: 93 RFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVL 152
AET D+ + D + T ++ Q +D+ + + L +
Sbjct: 1299 --EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANM 1356
Query: 153 DAMFERIVKADEHVIDQGDD 172
E+I +E +D ++
Sbjct: 1357 QKSREKIKDKEETELDSEEE 1376
Score = 30.4 bits (67), Expect = 3.0
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 10/85 (11%)
Query: 79 ESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEA--CKD 136
E ED D E P+P T+ DEEEE+ D + P+ +R Q+ C+
Sbjct: 1047 EPFEDSDSERPMPR--------LEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQS 1098
Query: 137 ILLFKNLDQEQLSQVLDAMFERIVK 161
K+ D+E+ + DA I+K
Sbjct: 1099 SSKRKSKDEEEDEESDDADDTPILK 1123
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 38.9 bits (89), Expect = 0.008
Identities = 26/116 (22%), Positives = 49/116 (42%), Gaps = 12/116 (10%)
Query: 256 IESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTK 315
+ +PL + S ++ + ++++ G+ ++ +G Y I+ G +S+L R
Sbjct: 423 VAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD 482
Query: 316 SNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLL 371
+ R G YFGE+ L+T R AS A + + V F +L
Sbjct: 483 T------------RLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVL 526
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 38.1 bits (87), Expect = 0.014
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 16/120 (13%)
Query: 70 RVADAKGDSESEEDEDLEVPVPSRFNRR--VSVCAETYNPDEEEEDTDPRVIHPKTDEQR 127
R+ + DSE +E+ED E+ R V C E D+ ++D +
Sbjct: 222 RLPEGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIE------------ 269
Query: 128 CRLQEACKDILLFKNLDQEQLSQVLDAM-FERIVKADEHVIDQGDDGDNFYVIERGTYDI 186
+L E + F N+ ++ M FE + +A +++ G + D++YVI GT +I
Sbjct: 270 -QLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEI 328
Score = 32.0 bits (71), Expect = 1.0
Identities = 17/55 (30%), Positives = 32/55 (58%), Gaps = 1/55 (1%)
Query: 255 FIESVPLLKSLEVSERMKIVDV-IGEKIYKDGERIITQGEKADSFYIIESGEVSI 308
F+ +P ++ +S R ++ V I E + + G I+ G++ DS+Y+I +G V I
Sbjct: 274 FMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEI 328
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 37.7 bits (86), Expect = 0.019
Identities = 29/110 (26%), Positives = 54/110 (49%), Gaps = 6/110 (5%)
Query: 137 ILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRS 196
+ LF+ D++ + +L + + +++V +G+ G Y+I+ G +L D +S
Sbjct: 960 VALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDG--KS 1017
Query: 197 VGQYDNRGS-FGELALMY---NTPRAATIVATSEGSLWGLDRVTFRRIIV 242
V GS FGE++L+ R A +VA +L+ LD+ I+V
Sbjct: 1018 VLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILV 1067
Score = 31.2 bits (69), Expect = 1.7
Identities = 21/94 (22%), Positives = 40/94 (42%), Gaps = 12/94 (12%)
Query: 281 IYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELA 340
+Y + + +GE YII++G+V +L G + + + G FGE++
Sbjct: 982 VYLPNDYVCKKGEIGREMYIIQAGQVQVL---------GGPDGKSVLVTLKAGSVFGEIS 1032
Query: 341 LVT---NKPRAASAYAVGDVKCLVMDVQAFERLL 371
L+ R A+ A G ++D + +L
Sbjct: 1033 LLAVGGGNRRTANVVAHGFTNLFILDKKDLNEIL 1066
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 37.7 bits (86), Expect = 0.019
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 139 LFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVG 198
LFK D + + +L + + + V +G+ G Y+I+ G +L D T+ +
Sbjct: 524 LFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDG-TKVLV 582
Query: 199 QYDNRGSFGELALMY---NTPRAATIVATSEGSLWGLDRVTFRRIIV 242
FGE++L+ R A +VA +L LD+ T + I+V
Sbjct: 583 TLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILV 629
Score = 37.4 bits (85), Expect = 0.024
Identities = 31/121 (25%), Positives = 50/121 (41%), Gaps = 12/121 (9%)
Query: 254 SFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSR 313
S I V L K + ++ + +Y G+ + +GE YII+ GEV +L
Sbjct: 517 SIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVL---- 572
Query: 314 TKSNKDGGNQEVEIARCHKGQYFGELALVT---NKPRAASAYAVGDVKCLVMDVQAFERL 370
DG V + G FGE++L+ R A+ A G L +D + + +
Sbjct: 573 --GGPDGTKVLVTL---KAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEI 627
Query: 371 L 371
L
Sbjct: 628 L 628
>gi|18201890 hypothetical protein LOC140894 [Homo sapiens]
Length = 572
Score = 37.4 bits (85), Expect = 0.024
Identities = 33/149 (22%), Positives = 64/149 (42%), Gaps = 5/149 (3%)
Query: 166 VIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYD---NRGS-FGELALMYNTPRAATI 221
+I +G G++FY I GT I +D + + + ++GS FGE+ +++ + R +TI
Sbjct: 143 IIKKGQKGNSFYFIYLGTVAITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTI 202
Query: 222 VATSEGSLWGLDRVTFRRIIVKNNAKKRKMFE-SFIESVPLLKSLEVSERMKIVDVIGEK 280
V E +DR F + +K + F + L S + ++V + +
Sbjct: 203 VCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMELFASWSDEKLWQLVAMAKIE 262
Query: 281 IYKDGERIITQGEKADSFYIIESGEVSIL 309
+ G+ I ++ I G +L
Sbjct: 263 RFSYGQLISKDFGESPFIMFISKGSCEVL 291
Score = 35.8 bits (81), Expect = 0.071
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 8/82 (9%)
Query: 288 IITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQ--EVEIARCHKGQYFGELALVTNK 345
II +G+K +SFY I G V+I ++DG + + HKG FGE+ ++
Sbjct: 143 IIKKGQKGNSFYFIYLGTVAI------TKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHAS 196
Query: 346 PRAASAYAVGDVKCLVMDVQAF 367
R ++ + + + LV+D + F
Sbjct: 197 VRRSTIVCMEETEFLVVDREDF 218
>gi|21359920 ropporin [Homo sapiens]
Length = 212
Score = 37.0 bits (84), Expect = 0.032
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 6 IPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAP 46
IPP L ++L+ + +R QP DL+++A +YF L P
Sbjct: 10 IPPELPKMLKEFAKAAIRVQPQDLIQWAADYFEALSRGETP 50
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,277,373
Number of Sequences: 37866
Number of extensions: 820451
Number of successful extensions: 4555
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 4320
Number of HSP's gapped (non-prelim): 228
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.