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Search of human proteins with 4758822
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758822 nephrin precursor [Homo sapiens]
(1241 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758822 nephrin precursor [Homo sapiens] 2513 0.0
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 161 3e-39
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 161 3e-39
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 161 3e-39
gi|118572606 hemicentin 1 [Homo sapiens] 156 1e-37
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 126 1e-28
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 126 1e-28
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 125 2e-28
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 125 2e-28
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 123 1e-27
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 123 1e-27
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 118 3e-26
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 118 3e-26
gi|166295173 kin of IRRE like [Homo sapiens] 114 4e-25
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] 113 1e-24
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens] 112 3e-24
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens] 112 3e-24
gi|110349719 titin isoform N2-A [Homo sapiens] 110 1e-23
gi|205277425 immunoglobulin superfamily, member 9 isoform a [Hom... 108 4e-23
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 106 1e-22
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 102 2e-21
gi|75709184 contactin 3 [Homo sapiens] 102 3e-21
gi|119220552 sidekick 1 [Homo sapiens] 99 3e-20
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 98 6e-20
gi|4506569 roundabout 1 isoform a [Homo sapiens] 96 2e-19
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 96 2e-19
gi|205277423 immunoglobulin superfamily, member 9 isoform b [Hom... 96 3e-19
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 94 8e-19
gi|19743806 roundabout 1 isoform b [Homo sapiens] 94 1e-18
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 94 1e-18
>gi|4758822 nephrin precursor [Homo sapiens]
Length = 1241
Score = 2513 bits (6513), Expect = 0.0
Identities = 1241/1241 (100%), Positives = 1241/1241 (100%)
Query: 1 MALGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGS 60
MALGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGS
Sbjct: 1 MALGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGS 60
Query: 61 AVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGP 120
AVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGP
Sbjct: 61 AVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGP 120
Query: 121 ELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTI 180
ELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTI
Sbjct: 121 ELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTI 180
Query: 181 SDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP 240
SDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP
Sbjct: 181 SDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP 240
Query: 241 GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS
Sbjct: 241 GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
Query: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLS 360
VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLS
Sbjct: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLS 360
Query: 361 CVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAF 420
CVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAF
Sbjct: 361 CVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAF 420
Query: 421 SEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYK 480
SEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYK
Sbjct: 421 SEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYK 480
Query: 481 DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLA 540
DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLA
Sbjct: 481 DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLA 540
Query: 541 VQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFK 600
VQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFK
Sbjct: 541 VQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFK 600
Query: 601 GSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVE 660
GSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVE
Sbjct: 601 GSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVE 660
Query: 661 QGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLH 720
QGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLH
Sbjct: 661 QGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLH 720
Query: 721 CQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGE 780
CQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGE
Sbjct: 721 CQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGE 780
Query: 781 DEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQV 840
DEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQV
Sbjct: 781 DEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQV 840
Query: 841 EHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH 900
EHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH
Sbjct: 841 EHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH 900
Query: 901 SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLE 960
SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLE
Sbjct: 901 SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLE 960
Query: 961 WKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG 1020
WKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG
Sbjct: 961 WKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG 1020
Query: 1021 DSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASC 1080
DSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASC
Sbjct: 1021 DSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASC 1080
Query: 1081 VGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYR 1140
VGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYR
Sbjct: 1081 VGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYR 1140
Query: 1141 SLRDFSPQLPPTQEEVSYSRGFTGEDEDMAFPGHLYDEVERTYPPSGAWGPLYDEVQMGP 1200
SLRDFSPQLPPTQEEVSYSRGFTGEDEDMAFPGHLYDEVERTYPPSGAWGPLYDEVQMGP
Sbjct: 1141 SLRDFSPQLPPTQEEVSYSRGFTGEDEDMAFPGHLYDEVERTYPPSGAWGPLYDEVQMGP 1200
Query: 1201 WDLHWPEDTYQDPRGIYDQVAGDLDTLEPDSLPFELRGHLV 1241
WDLHWPEDTYQDPRGIYDQVAGDLDTLEPDSLPFELRGHLV
Sbjct: 1201 WDLHWPEDTYQDPRGIYDQVAGDLDTLEPDSLPFELRGHLV 1241
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 161 bits (408), Expect = 3e-39
Identities = 265/967 (27%), Positives = 375/967 (38%), Gaps = 134/967 (13%)
Query: 21 LAQLAIPA--SVPRGFWALPENLTVVE-GASVELRCGVST-PGSAVQWAKDGLLLGPDPR 76
L+ L PA PRG P++ +V G L C P V W KDG L R
Sbjct: 1832 LSVLVPPAFRQAPRG----PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 1887
Query: 77 IPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPK 136
RG L I+ +SD Y C+V S + E V L++ VPP
Sbjct: 1888 TQAL----------RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRT-FTLTVQVPPT 1934
Query: 137 LLLLTPEAGTMVTWVAGQEYVVNC-VSGDAKPAPDITILLSGQTI--SDISANVNEGSQQ 193
P+ T V+ VAG V+ C VSG PAP +T L + S + V+ G +
Sbjct: 1935 FE--NPKTET-VSQVAGSPLVLTCDVSG--VPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1989
Query: 194 KLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLD-E 252
+L +R+ P + C A + EA + F V VL P I G+ E
Sbjct: 1990 QL------SRLQPAQAGT---YTCVAENTQAEA--RKDFVVAVLVAPR---IRSSGVARE 2035
Query: 253 GHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMT-VRPEDH 311
HV GQ + L C A G P + WLK+G P+ G + LV+ +R D
Sbjct: 2036 HHVLEGQEVRLDCEA-DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2094
Query: 312 GAQLSCEAHNSVSAGTQEHGITLQVTFPPS---AIIILGSASQTENKNVTLSCVSKSSRP 368
GA +C AHN + H T+ V PP+ G+ + VT+ C + S P
Sbjct: 2095 GAY-TCVAHNPAGEDARLH--TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2151
Query: 369 RVLLRWWLGWRQLLPMEETVMDGLHG-GHISMSNLTFLARREDNGLTLTCEAFSEAFTKE 427
+ WL LP+ + + LHG GH + LA D G+ TC A S A +
Sbjct: 2152 IHVS--WLKDGLPLPLSQRTL--LHGSGHTLRISKVQLA---DAGI-FTCVAASPAGVAD 2203
Query: 428 TFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE 487
++ L V+ P +E + +R G+ V L C A G P P + W KD +
Sbjct: 2204 ---RNFTLQVQVPPVLEPVEFQNDVVVVR-GSLVELPCEA-RGVPLPLVSWMKDGEPLLS 2258
Query: 488 SRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPP-T 546
L Q G + E V +AG+ QL V PP
Sbjct: 2259 QSLEQ-------------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHI 2305
Query: 547 NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAAR 606
+ +L PG + L C P N++W K+G+ L + S A R
Sbjct: 2306 EDSGQPTELSLTPGAPMELLC-DAQGTPQPNITWHKDGQALTRLE--------NNSRATR 2356
Query: 607 SVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQ-VLVVTAVEQGEAL 665
+L+V RD G TC A S + +R+ V P +G + V + G+ +
Sbjct: 2357 --VLRV--RDAGL-YTCLAESPA--GAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV 2409
Query: 666 LPVSVSANPAPEAFNWTFRGYRLSPAGGP----RHRILSSGALHLWNVTRADDGLYQLHC 721
L SV A PAP+ W G L R R L AL + AD G Y
Sbjct: 2410 LECSVEAEPAPK-ITWHRDGIVLQEDAHTQFPERGRFLQLQAL-----STADSGDYSCTA 2463
Query: 722 QNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGED 781
+N+ G+ R+++H PTIR+ V+V + + C D P + +R+ D
Sbjct: 2464 RNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD 2523
Query: 782 EEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPAR-RLLRLVVRFAPQV 840
+ + P G LRI AG Y C+ N + R LR++ P
Sbjct: 2524 PRSPRFEIL------PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL---EPPA 2574
Query: 841 EHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH 900
P+P A + A L C A G P + W K+G LD R + Y +
Sbjct: 2575 IAPSPSNLTLTA---HTPALLPCEASGSPKPLVVWWKDGQKLDF---RLQQGAYRLLPSN 2628
Query: 901 SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP---DPPSGLKV-----VSL 952
+ LLT QD A F C +N +G Q+ P D + V V L
Sbjct: 2629 ALLLT---APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVL 2685
Query: 953 TPHSVGL 959
T HS G+
Sbjct: 2686 TCHSTGI 2692
Score = 156 bits (394), Expect = 1e-37
Identities = 231/885 (26%), Positives = 340/885 (38%), Gaps = 131/885 (14%)
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQE 155
L IE DL D+ Y C + + E V L +LVPP + E G + V
Sbjct: 659 LQIEKVDLRDEGIYTCAA--TNLAGES-KREVALKVLVPPNI-----EPGPVNKAVLENA 710
Query: 156 YVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLL 215
V P PD++ Q +S V ++ +E A+++ S
Sbjct: 711 SVTLECLASGVPPPDVSWFKGHQPVSSWMG-VTVSVDGRVLRIEQ-AQLSDAGSYR---- 764
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLAT 275
C AS+ A ++ VNV PP I P G V + L C A G P T
Sbjct: 765 -CVASNVAGSTELRYGLRVNV-----PPRITLPPSLPGPVLVNTPVRLTCNATGA-PSPT 817
Query: 276 LQWLKNGQPVSTAWGTEHTQAV--ARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
L WLK+G PVS A GT Q R + + + R D G + SC A ++V Q+ +
Sbjct: 818 LMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSG-RYSCVAVSAVGEDRQD--VV 873
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
LQV PPS + + S N++V L C S + P V L WW R L P
Sbjct: 874 LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKDGRPLEPRP-------- 924
Query: 394 GGHISMSNLTFLARRED--NGLTLTCEAFSEAFTKETFKKSLILNV----KYPAQKLWIE 447
G H+S R D + TCEA ++A E K LNV +P ++
Sbjct: 925 GVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSE---KHYNLNVWVAPVFPLRE---- 977
Query: 448 GPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGS 507
+R G L C G P P + W KD + LP E G+ + S
Sbjct: 978 --SHTLTVREGHPTSLSC-ECRGVPFPKISWRKDGQP-----LPGE------GAGLQHVS 1023
Query: 508 TFSRELVLVTGPSDNQAKFTCK----AGQLSASTQLAVQF---------PPTNVTILANA 554
R L L + +TC+ G S QL V PPT V+++ +
Sbjct: 1024 AVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDG 1083
Query: 555 SALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSS 614
A L C + + PP ++W+++G+ + + +S+ ++ +
Sbjct: 1084 VA-------TLEC-NATGKPPPTVTWERDGQPVGA------ELGLQLQNQGQSLHVERAQ 1129
Query: 615 RDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLG--EQVLVVTAVEQGEALLPVSVSA 672
H R +C A + L + L+VL PE +G + + +TA L
Sbjct: 1130 AAHTGRYSCVAEN--LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMG 1187
Query: 673 NPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARL 732
P P A W FRG G + + L + D GLY N G A
Sbjct: 1188 IP-PPAIRW-FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNF 1245
Query: 733 RLDVHYAPTI--RALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDM 790
++V P+I L++ +V G + ++C V +P W + D + D
Sbjct: 1246 SVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP--QPKLTWFK---DGRPLARGDA 1300
Query: 791 EKISRGPTG-RLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKV 849
IS P G L++ A L+ AG Y CI N V + +L V A PT L
Sbjct: 1301 HHIS--PDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH-FQLSVLLA-----PTILGGA 1352
Query: 850 AAAGDSTSSATLH------CRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSL 903
+ D + T++ C A P+ TW K+G P + + + G H
Sbjct: 1353 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA-----SRNIQLLPGTHG-- 1405
Query: 904 LTIANVSAAQDYALFTCTATNALGSDQTNIQL-----VSISRPDP 943
L I N + +D +TC TN LG N + SIS+ DP
Sbjct: 1406 LQILN-AQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDP 1449
Score = 150 bits (380), Expect = 6e-36
Identities = 260/1068 (24%), Positives = 395/1068 (36%), Gaps = 168/1068 (15%)
Query: 31 PRGFWALPEN--LTVVEGASVELRC---GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRL 85
P W E + V+E V+L C GV TP + W KDG LL ++
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN--ITWFKDGALLPTSTKVVY------ 360
Query: 86 EGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAG 145
RG L + SD Y C+ + E + L + VPP + AG
Sbjct: 361 ----TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR---LDVYVPPTI----EGAG 409
Query: 146 T---MVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATA 202
+V VAG+ + CV+ P+P ++ G ++ E ++ +L T +
Sbjct: 410 GRPYVVKAVAGRPVALECVAR-GHPSPTLSWHHEGLPVA-------ESNESRLETDGSVL 461
Query: 203 RVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLE 262
R+ + L C ASSPA EA ++ ++V V PP V E GL + GQ LE
Sbjct: 462 RLESPGEASSGLYSCVASSPAGEAVLQ--YSVEVQVPPQLLVAE--GLGQVTTIVGQPLE 517
Query: 263 LPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNS 322
LPC A G+P+ T+QWL+NG+P G + A + L + DH +C+A N
Sbjct: 518 LPCQA-SGSPVPTIQWLQNGRPAEELAGVQ--VASQGTTLHIDHVELDHSGLFACQATNE 574
Query: 323 VSAGTQEHGITLQVTFPPSAI-IILGSA--SQTENKNVTLSCVSKSSR-------PRVLL 372
E +++ + P + + +G + + +C R P ++
Sbjct: 575 AGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 634
Query: 373 RW------WLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTK 426
W W G +P+ ++ L + + D G+ TC A + A
Sbjct: 635 GWCSPGSLW-GEPTGIPVAYSLPPPLQIEKVDL---------RDEGI-YTCAATNLAGES 683
Query: 427 ETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVT 486
K+ + L V P IE P + + V L CLA G P P + W+K + V+
Sbjct: 684 ---KREVALKVLVPPN---IEPGPVNKAVLENASVTLECLA-SGVPPPDVSWFKGHQPVS 736
Query: 487 ESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQ----LAVQ 542
+ + S R L + + + C A ++ ST+ L V
Sbjct: 737 -------------SWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 783
Query: 543 FPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGS 602
PP + + + LTC + + P L W K+G + P + F G
Sbjct: 784 VPPRITLPPSLPGPVLVNTPVRLTC-NATGAPSPTLMWLKDGNPVSPAGTPGLQV-FPG- 840
Query: 603 AAARSVLLQVSSRDHGQRVTCRAHSA--ELRETVSSFYRLNVLYRPEFLGEQVLVVTAVE 660
R + L + R +C A SA E R+ V L V P LGE+ L V+ V
Sbjct: 841 --GRVLTLASARASDSGRYSCVAVSAVGEDRQDVV----LQVHMPPSILGEE-LNVSVVA 893
Query: 661 QGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLH 720
L A P P +W G L P G H L + D G Y
Sbjct: 894 NESVALECQSHAMP-PPVLSWWKDGRPLEPRPGV-HLSADKALLQVDRADVWDAGHYTCE 951
Query: 721 CQNSEGTAEARLRLDVHYAPTIRALQDPT-EVNVGGSVDIVCTVDANPILPGMFNWERLG 779
N G +E L+V AP + T V G + C P +W + G
Sbjct: 952 ALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPF--PKISWRKDG 1009
Query: 780 E--DEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFA 837
+ E L + + R L + A+LAQ G Y C N V ++ L+L V
Sbjct: 1010 QPLPGEGAGLQHVSAVGR----LLYLGQAQLAQEGTYTCECSNVVGNSSQD-LQLEVHVP 1064
Query: 838 PQVEHP-TPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVP------LDLQDPRYT 890
PQ+ P P T+V+ D ATL C A G P TW ++G P L LQ+ +
Sbjct: 1065 PQIAGPREPPTQVSVVQDGV--ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS 1122
Query: 891 EHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVV 950
H H+ ++C A N G + +L V
Sbjct: 1123 LHVERAQAAHT--------------GRYSCVAENLAGRAERKFEL-------------SV 1155
Query: 951 SLTPHSVG-LEWKPGFDGGLPQRFCIRYEALGTP-----GFHYVDVVPPQATTFTLTG-- 1002
+ P +G L+ L + EA+G P F + V P T+ L G
Sbjct: 1156 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW 1215
Query: 1003 ---LQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPED 1047
+ + L + A ++G A + + + P PS E ED
Sbjct: 1216 MLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP----PSIENED 1259
Score = 140 bits (354), Expect = 6e-33
Identities = 250/967 (25%), Positives = 371/967 (38%), Gaps = 120/967 (12%)
Query: 23 QLAIPASV----PRGFWALPENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRI 77
++ IP S+ P G + E T V +++ L C + P ++W KDG + P R+
Sbjct: 1437 EVLIPPSISKDDPLGEVGVKEVKTKVN-STLTLECESWAVPPPTIRWYKDGQPVTPSSRL 1495
Query: 78 PGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPP-- 135
RL L I+ +SD Y C V + G + V++ VPP
Sbjct: 1496 QVLGEGRL----------LQIQPTQVSDSGRYLC-VATNVAGEDDQDFNVLIQ--VPPMF 1542
Query: 136 ----------KLLLLTPEAGTMVTWVAGQEYVVN-----CVSGDAKPAPDITILLSGQTI 180
++L EA VT +E V N +A P PD+T Q +
Sbjct: 1543 QKVGDFSAAFEILSREEEARGGVTEY--REIVENNPAYLYCDTNAIPPPDLTWYREDQPL 1600
Query: 181 SDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP 240
S G + + ++ ++N C+AS+ E + + + VL PP
Sbjct: 1601 S-------AGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH--YELLVLTPP 1651
Query: 241 GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
++E V A ++ L C A G NP+ T+ WL+NG P S + + +
Sbjct: 1652 VILGDTEELVEEVTVNASSTVSLQCPALG-NPVPTISWLQNGLPFSPSPRLQVLE--DGQ 1708
Query: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPS-AIIILGSASQTENKNVTL 359
VL ++ A C A N AG+ E TL+V PP A + L + N +V+L
Sbjct: 1709 VLQVSTAEVADAASYMCVAEN--QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1766
Query: 360 SCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEA 419
C + P + W+ + L EE + L G H AR D+G+ TCEA
Sbjct: 1767 PC-DVHAHPNPEVTWYKDSQALSLGEEVFL--LPGTHTLQLG---RARLSDSGM-YTCEA 1819
Query: 420 FSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWY 479
+ A + + +L PA + GP + +R G + L C PEP++ WY
Sbjct: 1820 LNAAGRDQKLVQLSVL--VPPAFRQAPRGPQDAVLVRVGDKAVLSC-ETDALPEPTVTWY 1876
Query: 480 KDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQL 539
KD + + ++ Q R G + V+ K + AG+ + L
Sbjct: 1877 KDGQPLVLAQRTQALR---------GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTL 1927
Query: 540 AVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPF 599
VQ PPT + G L LTC VS P ++W K+ +E A
Sbjct: 1928 TVQVPPTFENPKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKDRMPVESSAV------- 1979
Query: 600 KGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAV 659
+R LQ+S Q T + + + + VL P V V
Sbjct: 1980 -HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHV 2038
Query: 660 EQG-EALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRI-LSSGALHLWNVTRADDGLY 717
+G E L P P+ W G L GP R L G+L L + +D G Y
Sbjct: 2039 LEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 2097
Query: 718 QLHCQNSEGTAEARLR-LDVHYAPTIRALQDPTEVNV---GGSVDIVCTVDANPILPGMF 773
N G +ARL ++V PTI+ D + V G V +VC V +P P
Sbjct: 2098 TCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP--PIHV 2154
Query: 774 NWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLV 833
+W + G + G LRI +LA AG + C+ A PA R
Sbjct: 2155 SWLKDGLPLP----LSQRTLLHGSGHTLRISKVQLADAGIFTCV----AASPAGVADR-- 2204
Query: 834 VRFAPQVEHPTPLTKVAAAGDST----SSATLHCRARGVPNIVFTWTKNGVPLDLQDPRY 889
F QV+ P L V D S L C ARGVP + +W K+G PL
Sbjct: 2205 -NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL------- 2256
Query: 890 TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPD-PPSGLK 948
+ QG L + V A D ++C A + G + + QL + P SG
Sbjct: 2257 LSQSLEQG----PSLQLEAVGAG-DSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQP 2311
Query: 949 V-VSLTP 954
+SLTP
Sbjct: 2312 TELSLTP 2318
Score = 130 bits (328), Expect = 6e-30
Identities = 237/932 (25%), Positives = 359/932 (38%), Gaps = 125/932 (13%)
Query: 43 VVEGASVELRCGVS-TPGSAVQWAKDGLLLGPD--PRIPGFPRYRLEGDPARGEFHLHIE 99
V+EG V L C P V W KDG LG D P + R+ L+G L ++
Sbjct: 2038 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHL----RFYLDGGS------LVLK 2087
Query: 100 ACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVN 159
SD Y C V + G + V ++LVPP + +GT+V+ +V
Sbjct: 2088 GLRASDAGAYTC-VAHNPAGEDARLHTV--NVLVPPTIKQGADGSGTLVSRPGELVTMVC 2144
Query: 160 CVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEA 219
V G P ++ L G + + GS T R++ + + C A
Sbjct: 2145 PVRGS--PPIHVSWLKDGLPLPLSQRTLLHGSGH-------TLRISKVQLADAGIFTCVA 2195
Query: 220 SSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWL 279
+SPA A +FT+ V PP +E+ ++ V G +ELPC ARG PL + W+
Sbjct: 2196 ASPAGVAD--RNFTLQVQVPPVLEPVEFQ--NDVVVVRGSLVELPCEARGV-PLPLVSWM 2250
Query: 280 KNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFP 339
K+G+P+ + + S+ + V D G SC A + AG L V P
Sbjct: 2251 KDGEPLLS-----QSLEQGPSLQLEAVGAGDSGTY-SCVAVSE--AGEARRHFQLTVMEP 2302
Query: 340 PSAIIILGSASQTE-----NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHG 394
P I S TE + L C ++ + P+ + W + L +E
Sbjct: 2303 PH---IEDSGQPTELSLTPGAPMELLCDAQGT-PQPNITWHKDGQALTRLENN------- 2351
Query: 395 GHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQK 454
S T + R D GL TC A S A E KS + V+ P + GP
Sbjct: 2352 -----SRATRVLRVRDAGL-YTCLAESPAGAIE---KSFRVRVQAPPNIVGPRGPRFVVG 2402
Query: 455 LRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE---SRLPQESRRVHLGSVEKSGSTFSR 511
L G V L C ++ P P + W++D + E ++ P+ R + L ++ + S
Sbjct: 2403 LAPGQLV-LEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGD-- 2458
Query: 512 ELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
+ + N A T A ++ T ++ P V + N +AL P A +
Sbjct: 2459 ----YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV------ 2508
Query: 572 SNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELR 631
P +SW K+ L+ PR F+ + V ++D G + ++SA
Sbjct: 2509 --PAPLVSWRKDRVPLD-----PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2561
Query: 632 ETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFR---GYRL 688
L VL P + +T ALLP S +P P W +RL
Sbjct: 2562 RQGRD---LRVL-EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2617
Query: 689 SPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDP 748
+R+L S AL L D ++ N G A ++ VH PTI D
Sbjct: 2618 QQGA---YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIA--DDQ 2672
Query: 749 TEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKL 808
T+ V +V T + I +W + G + ++S P+G L I A
Sbjct: 2673 TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG--YRVS--PSGALEIGQALP 2728
Query: 809 AQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGV 868
AG Y C N A A + + L V+ +P V+ PL V A + L C A G+
Sbjct: 2729 IHAGRYTCSARNS-AGVAHKHVFLTVQASPVVK---PLPSVVRAV-AEEEVLLPCEASGI 2783
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAA----QDYALFTCTATN 924
P TW K G+ + GV + +L + A +D + C A N
Sbjct: 2784 PRPTITWQKEGLNVAT-------------GVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 2830
Query: 925 ALGSDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
+ GS +LV P +GL +S T S
Sbjct: 2831 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGS 2862
Score = 126 bits (316), Expect = 1e-28
Identities = 232/913 (25%), Positives = 356/913 (38%), Gaps = 128/913 (14%)
Query: 46 GASVELRCGV-STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLS 104
G V + C V +P V W KDGL L P R L G L I L+
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLLHGSGHT----LRISKVQLA 2186
Query: 105 DDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGD 164
D + C V S G + L + VPP +L E V V G + C +
Sbjct: 2187 DAGIFTC-VAASPAG--VADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARG 2241
Query: 165 AKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPAL 224
P P ++ + G+ + +S ++ +G +L V A T C A S A
Sbjct: 2242 V-PLPLVSWMKDGEPL--LSQSLEQGPSLQLEAVGAGDSGT---------YSCVAVSEAG 2289
Query: 225 EAPIKASFTVNVLFPPGPPVIEWPGLD-EGHVRAGQSLELPCVARGGNPLATLQWLKNGQ 283
EA + F + V+ PP IE G E + G +EL C A+G P + W K+GQ
Sbjct: 2290 EA--RRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQG-TPQPNITWHKDGQ 2343
Query: 284 PVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAI 343
++ + +R+ V+ VR D G +C A + AG E ++V PP+ +
Sbjct: 2344 ALT------RLENNSRATRVLRVR--DAGLY-TCLAESP--AGAIEKSFRVRVQAPPNIV 2392
Query: 344 ------IILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGL--HGG 395
++G A + L C S + P + W R + ++E G
Sbjct: 2393 GPRGPRFVVGLAPG----QLVLEC-SVEAEPAPKITWH---RDGIVLQEDAHTQFPERGR 2444
Query: 396 HISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKL 455
+ + L+ D+G +C A + A + S+ V+ GPP +
Sbjct: 2445 FLQLQALS----TADSG-DYSCTARNAAGST-----SVAFRVEIHTVPTIRSGPP-AVNV 2493
Query: 456 RAGTRVRLVCLAIGGNPEPSLMWYKDS-----RTVTESRLPQESRRVHLGSVEKSGSTFS 510
L C A G P P + W KD R+ LP+ S R+ + +G
Sbjct: 2494 SVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLC 2552
Query: 511 RELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSV 570
L + SD Q + L A+ P+N+T+ A+ AL P +A
Sbjct: 2553 --LASNSAGSDRQGR------DLRVLEPPAIAPSPSNLTLTAHTPALLPCEA-------- 2596
Query: 571 SSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAEL 630
S +P + W K+G++L+ +A +LL + C S E+
Sbjct: 2597 SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA----LLLTAPGPQDSAQFECVV-SNEV 2651
Query: 631 RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSP 690
E Y++ V P +Q T +L + PAP +W+ G +L
Sbjct: 2652 GEA-HRLYQVTVHVPPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTV-SWSKAGAQLG- 2707
Query: 691 AGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTE 750
A G +R+ SGAL + G Y +NS G A + L V +P ++ L P+
Sbjct: 2708 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPL--PSV 2765
Query: 751 VNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRG--PTGRLRIHHAKL 808
V +++ +A+ I W++ G L+ +S P G+LRI HA
Sbjct: 2766 VRAVAEEEVLLPCEASGIPRPTITWQKEG-------LNVATGVSTQVLPGGQLRIAHASP 2818
Query: 809 AQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGV 868
AG Y CI N A A RLVV+ P +E+ P S A L C+ARG
Sbjct: 2819 EDAGNYLCIAKNS-AGSAMGKTRLVVQVPPVIENGLPDLSTTEG----SHAFLPCKARGS 2873
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGS 928
P TW K+G P+ + ++T S L + N+ QD +TCTA NA+G
Sbjct: 2874 PEPNITWDKDGQPVSGAEGKFTIQP-------SGELLVKNLE-GQDAGTYTCTAENAVGR 2925
Query: 929 DQTNIQLVSISRP 941
+ + L + P
Sbjct: 2926 ARRRVHLTILVLP 2938
Score = 115 bits (289), Expect = 2e-25
Identities = 221/931 (23%), Positives = 336/931 (36%), Gaps = 136/931 (14%)
Query: 31 PRGFWALPENLTVVEGASVELRCGVST-PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDP 89
PRG P + + + L C V P + W +DG++L D P
Sbjct: 2394 PRG----PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQF---------P 2440
Query: 90 ARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVT 149
RG F L ++A +D +Y C R+ G V+ RV I P + P V
Sbjct: 2441 ERGRF-LQLQALSTADSGDYSC-TARNAAGSTSVAFRV--EIHTVPTIRSGPPAVNVSVN 2496
Query: 150 WVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSS 209
A ++ C D PAP ++ + S E + R+ P +
Sbjct: 2497 QTA----LLPC-QADGVPAPLVSWRKDRVPLDPRSPRFE-------ILPEGSLRIQPVLA 2544
Query: 210 DNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARG 269
+ +C AS+ A + + VL PP P + A LPC A
Sbjct: 2545 QDAGHYLCLASNSA--GSDRQGRDLRVLEPPAIA----PSPSNLTLTAHTPALLPCEA-S 2597
Query: 270 GNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQE 329
G+P + W K+GQ + + + + L++T AQ C N V +
Sbjct: 2598 GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRL 2657
Query: 330 HGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVM 389
+ +T+ V PP+ + T V L+C S + P + W QL
Sbjct: 2658 YQVTVHV--PPTIADDQTDFTVTMMAPVVLTCHS-TGIPAPTVSWSKAGAQLGARGSGYR 2714
Query: 390 DGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP 449
G L A R TC A + A K + L V+ ++
Sbjct: 2715 VSPSGALEIGQALPIHAGR------YTCSARNSAGVAH---KHVFLTVQASPV---VKPL 2762
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTV----TESRLPQESRRVHLGSVEKS 505
P + A V L C A G P P++ W K+ V + LP R+ S E +
Sbjct: 2763 PSVVRAVAEEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDA 2821
Query: 506 GSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANASALRPGD 561
G+ + C AG T+L VQ PP L + S
Sbjct: 2822 GN------------------YLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSH 2863
Query: 562 ALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRV 621
A L C + S P N++WDK+G+ + G F + ++ + +D G
Sbjct: 2864 AF-LPCKARGSPEP-NITWDKDGQPVSGA-----EGKFTIQPSGELLVKNLEGQDAGT-Y 2915
Query: 622 TCRAHSAELRETVSSFYRLNVLYRPEFL---GEQVLVVTAVEQGEAL-LPVSVSANPAPE 677
TC A +A R L +L P F G++ L + G+ L L + +P P
Sbjct: 2916 TCTAENAVGR--ARRRVHLTILVLPVFTTLPGDRSLRL-----GDRLWLRCAARGSPTPR 2968
Query: 678 AFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVH 737
WT ++ + L V+R D G Y +N G +A + V
Sbjct: 2969 -IGWTVNDRPVTEGVSEQD---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 3024
Query: 738 YAPTIRA-----LQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEK 792
AP ++ L +P VGGS+ + C V +P+ +W + G L +
Sbjct: 3025 EAPVLQGEAFSYLVEP----VGGSIQLDCVVRGDPVPD--IHWIKDGLPLRGSHLRHQLQ 3078
Query: 793 ISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAP--QVEHPTPLTKVA 850
G L IH + AG YQC+ +N + A++++ LV++ AP QVE P
Sbjct: 3079 -----NGSLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAPVFQVE---PQDMTV 3129
Query: 851 AAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVS 910
+GD + L C+A G P W + G PL T + L + NV
Sbjct: 3130 RSGDDVA---LRCQATGEPTPTIEWLQAGQPLRASRRLRT--------LPDGSLWLENVE 3178
Query: 911 AAQDYALFTCTATNALGSDQTNIQLVSISRP 941
D + C A N LGS LV P
Sbjct: 3179 TG-DAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 115 bits (288), Expect = 3e-25
Identities = 231/950 (24%), Positives = 347/950 (36%), Gaps = 115/950 (12%)
Query: 53 CGV-STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYEC 111
CG TP V W K GP P + G E L + + +D +YEC
Sbjct: 24 CGTHGTPKPQVTWRK-----GPSSE----PLHGQPGVAVLEEGSLFLASVSPADSGDYEC 74
Query: 112 QVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDI 171
Q +E+G S R L + VPP + +A V+ +AGQ + C + P P+I
Sbjct: 75 QA-TNEVGS--TSRRAKLVVYVPPSIREDGRKAN--VSGMAGQSLTLEC-DANGFPVPEI 128
Query: 172 TILLSGQTIS----------DISANVNEGSQQKLFTVEAT--ARVTPRSSDNRQLLVCEA 219
L Q + D+ G + L ++ R+ P S R
Sbjct: 129 VWLKDAQLVGVPLGWAGYGWDLGWG-QVGGHRLLDEGQSLHFPRIQPGRSGRRGAQA--G 185
Query: 220 SSPALEAPIKASF-------TVNVLFPPGPPVIEWPGLDEGHVR-AGQSLELPCVARGGN 271
S +AP A T + PP PP + G + + AG +EL C G
Sbjct: 186 GSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWT-SGV 244
Query: 272 PLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHG 331
P ++W K+ QPV Q + + + D G + C A + AG Q
Sbjct: 245 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG-RYQCVAFSP--AGQQARD 301
Query: 332 ITLQVTFPPS--AIIILGSASQTENKNVTLSCVSKS-SRPRVLLRWWLGWRQLLPMEETV 388
L+V PP+ G + E+ V L C ++ P + W LLP V
Sbjct: 302 FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT---WFKDGALLPTSTKV 358
Query: 389 MDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEG 448
+ G + + A+ D G+ TC+A + E K+ L+V P G
Sbjct: 359 VYTRGGRQLQLGR----AQSSDAGV-YTCKASNAVGAAE---KATRLDVYVPPTIEGAGG 410
Query: 449 PPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGST 508
P K AG V L C+A G+P P+L W+ + V ES ESR +E GS
Sbjct: 411 RPYVVKAVAGRPVALECVA-RGHPSPTLSWHHEGLPVAES---NESR------LETDGSV 460
Query: 509 FSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTI--LANASALRPGDALNLT 566
E + AG+ + VQ PP + L + + G L L
Sbjct: 461 LRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTI-VGQPLELP 519
Query: 567 CVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVS--SRDHGQRVTCR 624
C S +P + W + G E +A A++ L + DH C+
Sbjct: 520 C-QASGSPVPTIQWLQNGRPAEELAGV--------QVASQGTTLHIDHVELDHSGLFACQ 570
Query: 625 AHS------AELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSV----SANP 674
A + AE+ +V + VL P +G+ A V A+P
Sbjct: 571 ATNEAGTAGAEVEVSVHGEWAPGVLEVP--IGQYHWGXEHHSSFPAACDPPVHRGWGAHP 628
Query: 675 APEAF-NWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLR 733
P W G G L + V D+G+Y N G ++ +
Sbjct: 629 KPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA 688
Query: 734 LDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKI 793
L V P I V SV + C P P +W + Q + +
Sbjct: 689 LKVLVPPNIEPGPVNKAVLENASVTLECLASGVP--PPDVSWFK-----GHQPVSSWMGV 741
Query: 794 SRGPTGR-LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAA 852
+ GR LRI A+L+ AG+Y+C+ N VA L V P++ P L
Sbjct: 742 TVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELRYGLRVNVPPRITLPPSLPGPVLV 800
Query: 853 GDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAA 912
+ L C A G P+ W K+G P+ P T G +LT+A+ + A
Sbjct: 801 ---NTPVRLTCNATGAPSPTLMWLKDGNPV---SPAGTPGLQVFPG--GRVLTLAS-ARA 851
Query: 913 QDYALFTCTATNALGSDQTNIQLVSISRPDPPSG--LKVVSLTPHSVGLE 960
D ++C A +A+G D+ ++ ++ + P G L V + SV LE
Sbjct: 852 SDSGRYSCVAVSAVGEDRQDV-VLQVHMPPSILGEELNVSVVANESVALE 900
Score = 105 bits (262), Expect = 3e-22
Identities = 242/1025 (23%), Positives = 371/1025 (36%), Gaps = 152/1025 (14%)
Query: 16 LLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKD------- 67
L E ++A+ VP P N V+E ASV L C S P V W K
Sbjct: 679 LAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSW 738
Query: 68 -GLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPEL---- 122
G+ + D R+ L IE LSD Y C EL
Sbjct: 739 MGVTVSVDGRV------------------LRIEQAQLSDAGSYRCVASNVAGSTELRYGL 780
Query: 123 ---VSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGD-AKPA--PDITILLS 176
V PR+ L +P +L+ TP T A ++ G+ PA P + +
Sbjct: 781 RVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPG 840
Query: 177 GQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNV 236
G+ ++ SA ++ + V A ++RQ +V + P P +NV
Sbjct: 841 GRVLTLASARASDSGRYSCVAVSAV-------GEDRQDVVLQVHMP----PSILGEELNV 889
Query: 237 LFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQA 296
V A +S+ L C + P L W K+G+P+ G H A
Sbjct: 890 -----------------SVVANESVALECQSH-AMPPPVLSWWKDGRPLEPRPGV-HLSA 930
Query: 297 VARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKN 356
+ V D G +CEA N + + + + V P + + + E
Sbjct: 931 DKALLQVDRADVWDAG-HYTCEALNQAGRSEKHYNLNVWVA-PVFPLRESHTLTVREGHP 988
Query: 357 VTLSCVSKS-SRPRVLLRWWLGWRQLLPMEETVMDGLHGGHIS-MSNLTFL--ARREDNG 412
+LSC + P++ W Q LP E G H+S + L +L A+ G
Sbjct: 989 TSLSCECRGVPFPKIS---WRKDGQPLPGE-----GAGLQHVSAVGRLLYLGQAQLAQEG 1040
Query: 413 LTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNP 472
T TCE + + L L V P Q PP + L C A G P
Sbjct: 1041 -TYTCECSNVVGNS---SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKP 1095
Query: 473 EPSLMWYKDSRTVTES---RLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCK 529
P++ W +D + V +L + + +H VE++ + + V ++N
Sbjct: 1096 PPTVTWERDGQPVGAELGLQLQNQGQSLH---VERAQAAHTGRYSCV---AEN------L 1143
Query: 530 AGQLSASTQLAVQFPPT---NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGER 586
AG+ +L+V PP ++ L N +A L L C ++ PP + W + E
Sbjct: 1144 AGRAERKFELSVLVPPELIGDLDPLTNITAAL-HSPLTLLCEAMGIPPPA-IRWFRGEEP 1201
Query: 587 LEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRP 646
+ P + + + Q +D G +C A S E E +F + VL P
Sbjct: 1202 VS-----PGEDTYLLAGGWMLKMTQTQEQDSG-LYSCLA-SNEAGEARRNF-SVEVLVPP 1253
Query: 647 EFLGEQVLVVTAVEQGE-ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA-L 704
E + V V G+ A L +V+ +P P+ W G L A G H I G L
Sbjct: 1254 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK-LTWFKDGRPL--ARGDAHHISPDGVLL 1310
Query: 705 HLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTI-----RALQDPTEVNVGGSVDI 759
+ + G Y N+ G +L V APTI + + V V + +
Sbjct: 1311 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISL 1370
Query: 760 VCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVD 819
+C A P W + G E + + G L+I +A+ AG Y C+V
Sbjct: 1371 ICEALAFP--SPNITWMKDGAPFEASRNIQLLPGTHG----LQILNAQKEDAGQYTCVVT 1424
Query: 820 NGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST---SSATLHCRARGVPNIVFTWT 876
N + + + V P + PL +V T S+ TL C + VP W
Sbjct: 1425 NELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY 1483
Query: 877 KNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQ-L 935
K+G P+ T + Q LL I + D + C ATN G D + L
Sbjct: 1484 KDGQPV-------TPSSRLQVLGEGRLLQI-QPTQVSDSGRYLCVATNVAGEDDQDFNVL 1535
Query: 936 VSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVD--VVPP 993
+ + PP KV + L + GG+ + R P + Y D +PP
Sbjct: 1536 IQV----PPMFQKVGDFSAAFEILSREEEARGGVTE---YREIVENNPAYLYCDTNAIPP 1588
Query: 994 QATTF 998
T+
Sbjct: 1589 PDLTW 1593
Score = 93.2 bits (230), Expect = 1e-18
Identities = 196/791 (24%), Positives = 287/791 (36%), Gaps = 99/791 (12%)
Query: 58 PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYEC----QV 113
P V W KD + L DPR P F E L I+ D Y C
Sbjct: 2509 PAPLVSWRKDRVPL--DPRSPRFE--------ILPEGSLRIQPVLAQDAGHYLCLASNSA 2558
Query: 114 GRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITI 173
G G +L +L PP + + + +T A ++ C P P +
Sbjct: 2559 GSDRQGRDL-------RVLEPPAIA----PSPSNLTLTAHTPALLPC-EASGSPKPLVVW 2606
Query: 174 LLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFT 233
GQ + + +G+ +L A P D+ Q C S+ EA T
Sbjct: 2607 WKDGQKLD---FRLQQGAY-RLLPSNALLLTAPGPQDSAQF-ECVVSNEVGEAHRLYQVT 2661
Query: 234 VNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEH 293
V+V PP I D V + L C + G P T+ W K G + A G+ +
Sbjct: 2662 VHV-----PPTIADDQTDFT-VTMMAPVVLTCHSTG-IPAPTVSWSKAGAQLG-ARGSGY 2713
Query: 294 TQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTE 353
+ + ++ + P H + +C A NS AG + L V P +
Sbjct: 2714 RVSPSGALEIGQALPI-HAGRYTCSARNS--AGVAHKHVFLTVQASPVVKPLPSVVRAVA 2770
Query: 354 NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGL 413
+ V L C + S PR + W + T + L GG + +++ A ED G
Sbjct: 2771 EEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQV--LPGGQLRIAH----ASPEDAGN 2823
Query: 414 TLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPE 473
L C A + A + K L++ V P IE G+ L C A G+PE
Sbjct: 2824 YL-CIAKNSAGSAMG-KTRLVVQVP-PV----IENGLPDLSTTEGSHAFLPCKA-RGSPE 2875
Query: 474 PSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA--- 530
P++ W KD + V+ G+ K S EL++ + +TC A
Sbjct: 2876 PNITWDKDGQPVS-------------GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2922
Query: 531 -GQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL-E 588
G+ L + P T+ + S LR GD L L C + S P + W + E
Sbjct: 2923 VGRARRRVHLTILVLPVFTTLPGDRS-LRLGDRLWLRCAARGSPTP-RIGWTVNDRPVTE 2980
Query: 589 GVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEF 648
GV+ GS R+ VS D G V C A + R SF ++V P
Sbjct: 2981 GVSEQDG-----GSTLQRAA---VSREDSGTYV-CWAENRVGRTQAVSF--VHVKEAPVL 3029
Query: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWN 708
GE + G L V +P P+ +W G L G L +G+L +
Sbjct: 3030 QGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IHWIKDGLPLR--GSHLRHQLQNGSLTIHR 3086
Query: 709 VTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPI 768
R D G YQ +N G A+ + L + AP + V G V + C P
Sbjct: 3087 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP- 3145
Query: 769 LPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARR 828
W + G Q L ++ P G L + + + AG Y C+ N + R
Sbjct: 3146 -TPTIEWLQAG-----QPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3199
Query: 829 LLRLVVRFAPQ 839
LVVR PQ
Sbjct: 3200 AF-LVVRGEPQ 3209
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 161 bits (408), Expect = 3e-39
Identities = 265/967 (27%), Positives = 375/967 (38%), Gaps = 134/967 (13%)
Query: 21 LAQLAIPA--SVPRGFWALPENLTVVE-GASVELRCGVST-PGSAVQWAKDGLLLGPDPR 76
L+ L PA PRG P++ +V G L C P V W KDG L R
Sbjct: 3023 LSVLVPPAFRQAPRG----PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 3078
Query: 77 IPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPK 136
RG L I+ +SD Y C+V S + E V L++ VPP
Sbjct: 3079 TQAL----------RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRT-FTLTVQVPPT 3125
Query: 137 LLLLTPEAGTMVTWVAGQEYVVNC-VSGDAKPAPDITILLSGQTI--SDISANVNEGSQQ 193
P+ T V+ VAG V+ C VSG PAP +T L + S + V+ G +
Sbjct: 3126 FE--NPKTET-VSQVAGSPLVLTCDVSG--VPAPTVTWLKDRMPVESSAVHGVVSRGGRL 3180
Query: 194 KLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLD-E 252
+L +R+ P + C A + EA + F V VL P I G+ E
Sbjct: 3181 QL------SRLQPAQAGT---YTCVAENTQAEA--RKDFVVAVLVAPR---IRSSGVARE 3226
Query: 253 GHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMT-VRPEDH 311
HV GQ + L C A G P + WLK+G P+ G + LV+ +R D
Sbjct: 3227 HHVLEGQEVRLDCEA-DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 3285
Query: 312 GAQLSCEAHNSVSAGTQEHGITLQVTFPPS---AIIILGSASQTENKNVTLSCVSKSSRP 368
GA +C AHN + H T+ V PP+ G+ + VT+ C + S P
Sbjct: 3286 GAY-TCVAHNPAGEDARLH--TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP 3342
Query: 369 RVLLRWWLGWRQLLPMEETVMDGLHG-GHISMSNLTFLARREDNGLTLTCEAFSEAFTKE 427
+ WL LP+ + + LHG GH + LA D G+ TC A S A +
Sbjct: 3343 IHVS--WLKDGLPLPLSQRTL--LHGSGHTLRISKVQLA---DAGI-FTCVAASPAGVAD 3394
Query: 428 TFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE 487
++ L V+ P +E + +R G+ V L C A G P P + W KD +
Sbjct: 3395 ---RNFTLQVQVPPVLEPVEFQNDVVVVR-GSLVELPCEA-RGVPLPLVSWMKDGEPLLS 3449
Query: 488 SRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPP-T 546
L Q G + E V +AG+ QL V PP
Sbjct: 3450 QSLEQ-------------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHI 3496
Query: 547 NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAAR 606
+ +L PG + L C P N++W K+G+ L + S A R
Sbjct: 3497 EDSGQPTELSLTPGAPMELLC-DAQGTPQPNITWHKDGQALTRLE--------NNSRATR 3547
Query: 607 SVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQ-VLVVTAVEQGEAL 665
+L+V RD G TC A S + +R+ V P +G + V + G+ +
Sbjct: 3548 --VLRV--RDAGL-YTCLAESPA--GAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV 3600
Query: 666 LPVSVSANPAPEAFNWTFRGYRLSPAGGP----RHRILSSGALHLWNVTRADDGLYQLHC 721
L SV A PAP+ W G L R R L AL + AD G Y
Sbjct: 3601 LECSVEAEPAPK-ITWHRDGIVLQEDAHTQFPERGRFLQLQAL-----STADSGDYSCTA 3654
Query: 722 QNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGED 781
+N+ G+ R+++H PTIR+ V+V + + C D P + +R+ D
Sbjct: 3655 RNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD 3714
Query: 782 EEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPAR-RLLRLVVRFAPQV 840
+ + P G LRI AG Y C+ N + R LR++ P
Sbjct: 3715 PRSPRFEIL------PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL---EPPA 3765
Query: 841 EHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH 900
P+P A + A L C A G P + W K+G LD R + Y +
Sbjct: 3766 IAPSPSNLTLTA---HTPALLPCEASGSPKPLVVWWKDGQKLDF---RLQQGAYRLLPSN 3819
Query: 901 SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP---DPPSGLKV-----VSL 952
+ LLT QD A F C +N +G Q+ P D + V V L
Sbjct: 3820 ALLLT---APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVL 3876
Query: 953 TPHSVGL 959
T HS G+
Sbjct: 3877 TCHSTGI 3883
Score = 155 bits (393), Expect = 2e-37
Identities = 226/882 (25%), Positives = 342/882 (38%), Gaps = 125/882 (14%)
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQE 155
L IE DL D+ Y C + + E V L +LVPP + E G + V
Sbjct: 1850 LQIEKVDLRDEGIYTCAA--TNLAGES-KREVALKVLVPPNI-----EPGPVNKAVLENA 1901
Query: 156 YVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLL 215
V P PD++ Q +S V ++ +E A+++ S
Sbjct: 1902 SVTLECLASGVPPPDVSWFKGHQPVSSWMG-VTVSVDGRVLRIEQ-AQLSDAGSYR---- 1955
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLAT 275
C AS+ A ++ VNV PP I P G V + L C A G P T
Sbjct: 1956 -CVASNVAGSTELRYGLRVNV-----PPRITLPPSLPGPVLVNTPVRLTCNATGA-PSPT 2008
Query: 276 LQWLKNGQPVSTAWGTEHTQAV--ARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
L WLK+G PVS A GT Q R + + + R D G + SC A ++V Q+ +
Sbjct: 2009 LMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSG-RYSCVAVSAVGEDRQD--VV 2064
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
LQV PPS + + S N++V L C S + P V L WW R L P
Sbjct: 2065 LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKDGRPLEPRP-------- 2115
Query: 394 GGHISMSNLTFLARRED--NGLTLTCEAFSEA-FTKETFKKSLILNVKYPAQKLWIEGPP 450
G H+S R D + TCEA ++A +++ + ++ + +P ++
Sbjct: 2116 GVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRE------S 2169
Query: 451 EGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFS 510
+R G L C G P P + W KD + LP E G+ + S
Sbjct: 2170 HTLTVREGHPTSLSC-ECRGVPFPKISWRKDGQP-----LPGE------GAGLQHVSAVG 2217
Query: 511 RELVLVTGPSDNQAKFTCK----AGQLSASTQLAVQF---------PPTNVTILANASAL 557
R L L + +TC+ G S QL V PPT V+++ + A
Sbjct: 2218 RLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA- 2276
Query: 558 RPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDH 617
L C + + PP ++W+++G+ + + +S+ ++ + H
Sbjct: 2277 ------TLEC-NATGKPPPTVTWERDGQPVGA------ELGLQLQNQGQSLHVERAQAAH 2323
Query: 618 GQRVTCRAHSAELRETVSSFYRLNVLYRPEFLG--EQVLVVTAVEQGEALLPVSVSANPA 675
R +C A + L + L+VL PE +G + + +TA L P
Sbjct: 2324 TGRYSCVAEN--LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIP- 2380
Query: 676 PEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLD 735
P A W FRG G + + L + D GLY N G A ++
Sbjct: 2381 PPAIRW-FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 2439
Query: 736 VHYAPTI--RALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKI 793
V P+I L++ +V G + ++C V +P W + D + D I
Sbjct: 2440 VLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP--QPKLTWFK---DGRPLARGDAHHI 2494
Query: 794 SRGPTG-RLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAA 852
S P G L++ A L+ AG Y CI N V + +L V A PT L +
Sbjct: 2495 S--PDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH-FQLSVLLA-----PTILGGAEDS 2546
Query: 853 GDSTSSATLH------CRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTI 906
D + T++ C A P+ TW K+G P + + + G H L I
Sbjct: 2547 ADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA-----SRNIQLLPGTHG--LQI 2599
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQL-----VSISRPDP 943
N + +D +TC TN LG N + SIS+ DP
Sbjct: 2600 LN-AQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDP 2640
Score = 140 bits (354), Expect = 6e-33
Identities = 250/967 (25%), Positives = 371/967 (38%), Gaps = 120/967 (12%)
Query: 23 QLAIPASV----PRGFWALPENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRI 77
++ IP S+ P G + E T V +++ L C + P ++W KDG + P R+
Sbjct: 2628 EVLIPPSISKDDPLGEVGVKEVKTKVN-STLTLECESWAVPPPTIRWYKDGQPVTPSSRL 2686
Query: 78 PGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPP-- 135
RL L I+ +SD Y C V + G + V++ VPP
Sbjct: 2687 QVLGEGRL----------LQIQPTQVSDSGRYLC-VATNVAGEDDQDFNVLIQ--VPPMF 2733
Query: 136 ----------KLLLLTPEAGTMVTWVAGQEYVVN-----CVSGDAKPAPDITILLSGQTI 180
++L EA VT +E V N +A P PD+T Q +
Sbjct: 2734 QKVGDFSAAFEILSREEEARGGVTEY--REIVENNPAYLYCDTNAIPPPDLTWYREDQPL 2791
Query: 181 SDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP 240
S G + + ++ ++N C+AS+ E + + + VL PP
Sbjct: 2792 S-------AGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH--YELLVLTPP 2842
Query: 241 GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
++E V A ++ L C A G NP+ T+ WL+NG P S + + +
Sbjct: 2843 VILGDTEELVEEVTVNASSTVSLQCPALG-NPVPTISWLQNGLPFSPSPRLQVLE--DGQ 2899
Query: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPS-AIIILGSASQTENKNVTL 359
VL ++ A C A N AG+ E TL+V PP A + L + N +V+L
Sbjct: 2900 VLQVSTAEVADAASYMCVAEN--QAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 2957
Query: 360 SCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEA 419
C + P + W+ + L EE + L G H AR D+G+ TCEA
Sbjct: 2958 PC-DVHAHPNPEVTWYKDSQALSLGEEVFL--LPGTHTLQLG---RARLSDSGM-YTCEA 3010
Query: 420 FSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWY 479
+ A + + +L PA + GP + +R G + L C PEP++ WY
Sbjct: 3011 LNAAGRDQKLVQLSVL--VPPAFRQAPRGPQDAVLVRVGDKAVLSC-ETDALPEPTVTWY 3067
Query: 480 KDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQL 539
KD + + ++ Q R G + V+ K + AG+ + L
Sbjct: 3068 KDGQPLVLAQRTQALR---------GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTL 3118
Query: 540 AVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPF 599
VQ PPT + G L LTC VS P ++W K+ +E A
Sbjct: 3119 TVQVPPTFENPKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKDRMPVESSAV------- 3170
Query: 600 KGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAV 659
+R LQ+S Q T + + + + VL P V V
Sbjct: 3171 -HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHV 3229
Query: 660 EQG-EALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRI-LSSGALHLWNVTRADDGLY 717
+G E L P P+ W G L GP R L G+L L + +D G Y
Sbjct: 3230 LEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 3288
Query: 718 QLHCQNSEGTAEARLR-LDVHYAPTIRALQDPTEVNV---GGSVDIVCTVDANPILPGMF 773
N G +ARL ++V PTI+ D + V G V +VC V +P P
Sbjct: 3289 TCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP--PIHV 3345
Query: 774 NWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLV 833
+W + G + G LRI +LA AG + C+ A PA R
Sbjct: 3346 SWLKDGLPLP----LSQRTLLHGSGHTLRISKVQLADAGIFTCV----AASPAGVADR-- 3395
Query: 834 VRFAPQVEHPTPLTKVAAAGDST----SSATLHCRARGVPNIVFTWTKNGVPLDLQDPRY 889
F QV+ P L V D S L C ARGVP + +W K+G PL
Sbjct: 3396 -NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL------- 3447
Query: 890 TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPD-PPSGLK 948
+ QG L + V A D ++C A + G + + QL + P SG
Sbjct: 3448 LSQSLEQG----PSLQLEAVGAG-DSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQP 3502
Query: 949 V-VSLTP 954
+SLTP
Sbjct: 3503 TELSLTP 3509
Score = 130 bits (328), Expect = 6e-30
Identities = 237/932 (25%), Positives = 359/932 (38%), Gaps = 125/932 (13%)
Query: 43 VVEGASVELRCGVS-TPGSAVQWAKDGLLLGPD--PRIPGFPRYRLEGDPARGEFHLHIE 99
V+EG V L C P V W KDG LG D P + R+ L+G L ++
Sbjct: 3229 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHL----RFYLDGGS------LVLK 3278
Query: 100 ACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVN 159
SD Y C V + G + V ++LVPP + +GT+V+ +V
Sbjct: 3279 GLRASDAGAYTC-VAHNPAGEDARLHTV--NVLVPPTIKQGADGSGTLVSRPGELVTMVC 3335
Query: 160 CVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEA 219
V G P ++ L G + + GS T R++ + + C A
Sbjct: 3336 PVRGS--PPIHVSWLKDGLPLPLSQRTLLHGSGH-------TLRISKVQLADAGIFTCVA 3386
Query: 220 SSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWL 279
+SPA A +FT+ V PP +E+ ++ V G +ELPC ARG PL + W+
Sbjct: 3387 ASPAGVAD--RNFTLQVQVPPVLEPVEFQ--NDVVVVRGSLVELPCEARGV-PLPLVSWM 3441
Query: 280 KNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFP 339
K+G+P+ + + S+ + V D G SC A + AG L V P
Sbjct: 3442 KDGEPLLS-----QSLEQGPSLQLEAVGAGDSGTY-SCVAVSE--AGEARRHFQLTVMEP 3493
Query: 340 PSAIIILGSASQTE-----NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHG 394
P I S TE + L C ++ + P+ + W + L +E
Sbjct: 3494 PH---IEDSGQPTELSLTPGAPMELLCDAQGT-PQPNITWHKDGQALTRLENN------- 3542
Query: 395 GHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQK 454
S T + R D GL TC A S A E KS + V+ P + GP
Sbjct: 3543 -----SRATRVLRVRDAGL-YTCLAESPAGAIE---KSFRVRVQAPPNIVGPRGPRFVVG 3593
Query: 455 LRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE---SRLPQESRRVHLGSVEKSGSTFSR 511
L G V L C ++ P P + W++D + E ++ P+ R + L ++ + S
Sbjct: 3594 LAPGQLV-LEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGD-- 3649
Query: 512 ELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
+ + N A T A ++ T ++ P V + N +AL P A +
Sbjct: 3650 ----YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV------ 3699
Query: 572 SNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELR 631
P +SW K+ L+ PR F+ + V ++D G + ++SA
Sbjct: 3700 --PAPLVSWRKDRVPLD-----PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 3752
Query: 632 ETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFR---GYRL 688
L VL P + +T ALLP S +P P W +RL
Sbjct: 3753 RQGRD---LRVL-EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 3808
Query: 689 SPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDP 748
+R+L S AL L D ++ N G A ++ VH PTI D
Sbjct: 3809 QQGA---YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIA--DDQ 3863
Query: 749 TEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKL 808
T+ V +V T + I +W + G + ++S P+G L I A
Sbjct: 3864 TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG--YRVS--PSGALEIGQALP 3919
Query: 809 AQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGV 868
AG Y C N A A + + L V+ +P V+ PL V A + L C A G+
Sbjct: 3920 IHAGRYTCSARNS-AGVAHKHVFLTVQASPVVK---PLPSVVRAV-AEEEVLLPCEASGI 3974
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAA----QDYALFTCTATN 924
P TW K G+ + GV + +L + A +D + C A N
Sbjct: 3975 PRPTITWQKEGLNVAT-------------GVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 4021
Query: 925 ALGSDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
+ GS +LV P +GL +S T S
Sbjct: 4022 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGS 4053
Score = 126 bits (316), Expect = 1e-28
Identities = 232/913 (25%), Positives = 356/913 (38%), Gaps = 128/913 (14%)
Query: 46 GASVELRCGV-STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLS 104
G V + C V +P V W KDGL L P R L G L I L+
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLLHGSGHT----LRISKVQLA 3377
Query: 105 DDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGD 164
D + C V S G + L + VPP +L E V V G + C +
Sbjct: 3378 DAGIFTC-VAASPAG--VADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARG 3432
Query: 165 AKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPAL 224
P P ++ + G+ + +S ++ +G +L V A T C A S A
Sbjct: 3433 V-PLPLVSWMKDGEPL--LSQSLEQGPSLQLEAVGAGDSGT---------YSCVAVSEAG 3480
Query: 225 EAPIKASFTVNVLFPPGPPVIEWPGLD-EGHVRAGQSLELPCVARGGNPLATLQWLKNGQ 283
EA + F + V+ PP IE G E + G +EL C A+G P + W K+GQ
Sbjct: 3481 EA--RRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQG-TPQPNITWHKDGQ 3534
Query: 284 PVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAI 343
++ + +R+ V+ VR D G +C A + AG E ++V PP+ +
Sbjct: 3535 ALT------RLENNSRATRVLRVR--DAGLY-TCLAESP--AGAIEKSFRVRVQAPPNIV 3583
Query: 344 ------IILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGL--HGG 395
++G A + L C S + P + W R + ++E G
Sbjct: 3584 GPRGPRFVVGLAPG----QLVLEC-SVEAEPAPKITWH---RDGIVLQEDAHTQFPERGR 3635
Query: 396 HISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKL 455
+ + L+ D+G +C A + A + S+ V+ GPP +
Sbjct: 3636 FLQLQALS----TADSG-DYSCTARNAAGST-----SVAFRVEIHTVPTIRSGPP-AVNV 3684
Query: 456 RAGTRVRLVCLAIGGNPEPSLMWYKDS-----RTVTESRLPQESRRVHLGSVEKSGSTFS 510
L C A G P P + W KD R+ LP+ S R+ + +G
Sbjct: 3685 SVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLC 3743
Query: 511 RELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSV 570
L + SD Q + L A+ P+N+T+ A+ AL P +A
Sbjct: 3744 --LASNSAGSDRQGR------DLRVLEPPAIAPSPSNLTLTAHTPALLPCEA-------- 3787
Query: 571 SSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAEL 630
S +P + W K+G++L+ +A +LL + C S E+
Sbjct: 3788 SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA----LLLTAPGPQDSAQFECVV-SNEV 3842
Query: 631 RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSP 690
E Y++ V P +Q T +L + PAP +W+ G +L
Sbjct: 3843 GEA-HRLYQVTVHVPPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTV-SWSKAGAQLG- 3898
Query: 691 AGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTE 750
A G +R+ SGAL + G Y +NS G A + L V +P ++ L P+
Sbjct: 3899 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPL--PSV 3956
Query: 751 VNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRG--PTGRLRIHHAKL 808
V +++ +A+ I W++ G L+ +S P G+LRI HA
Sbjct: 3957 VRAVAEEEVLLPCEASGIPRPTITWQKEG-------LNVATGVSTQVLPGGQLRIAHASP 4009
Query: 809 AQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGV 868
AG Y CI N A A RLVV+ P +E+ P S A L C+ARG
Sbjct: 4010 EDAGNYLCIAKNS-AGSAMGKTRLVVQVPPVIENGLPDLSTTEG----SHAFLPCKARGS 4064
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGS 928
P TW K+G P+ + ++T S L + N+ QD +TCTA NA+G
Sbjct: 4065 PEPNITWDKDGQPVSGAEGKFTIQP-------SGELLVKNLE-GQDAGTYTCTAENAVGR 4116
Query: 929 DQTNIQLVSISRP 941
+ + L + P
Sbjct: 4117 ARRRVHLTILVLP 4129
Score = 119 bits (299), Expect = 1e-26
Identities = 230/986 (23%), Positives = 350/986 (35%), Gaps = 199/986 (20%)
Query: 43 VVEGASVELRCGVS-TPGSAVQWAKDGL--LLGPDPRIPGFPRYRLEGDPARGEFHLHIE 99
V G L C S P V W + GL +L P+ G L I
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG---------------KLRIP 753
Query: 100 ACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVN 159
A D Y C+ +E+G S + L++ P+L L + VT G+ ++
Sbjct: 754 AAQERDAGTYTCRAV-NELGD--ASAEIQLAVGHAPQLTELPRD----VTVELGRSALLA 806
Query: 160 CVSGDAKPAPDITILLS-GQTIS-DISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVC 217
C +P P +T GQ + + A S+Q V V P +++ VC
Sbjct: 807 C-RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP---EDQAPYVC 862
Query: 218 EASSPALEAPIKASFTVNVLFPP----GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
EA + + +A V PP P + V GQ + LPC+ G PL
Sbjct: 863 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVR--------VLEGQPVSLPCIVLAGRPL 914
Query: 274 ATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
WLK+G+P+ G+ H+ A L + ++H + SC A N +AG+Q +
Sbjct: 915 PERHWLKDGRPLPP--GSRHS-IRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVE 969
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
L V PP E +L CV+ S P + W +ET
Sbjct: 970 LVVQVPPRIHPTATHHITNEGVPASLPCVA-SGVPAPTITW---------TKETNALTSR 1019
Query: 394 GGHISMSN----LTFLARREDNGLTLTCEAFSEAFTKETFKKSL--ILNVKYPAQK---- 443
G H ++S L +D G + + F+ + + S+ + KY ++
Sbjct: 1020 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLL 1079
Query: 444 ----------------------------------LWIEGPPEGQ------KLRAGTRVRL 463
L ++ PP+ Q K+ G + L
Sbjct: 1080 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDL 1139
Query: 464 VCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQ 523
C+A GNPEP L W KD V + R PQ S VH ++ S +
Sbjct: 1140 NCVA-EGNPEPQLSWSKDG-VVLQGRGPQGS--VHFAAIRTS----------------DA 1179
Query: 524 AKFTCKAGQLSA----STQLAVQFPP-TNVTILANASALRPGDALNLTCVSVSSNPPVNL 578
++ C+A + +L V PP + G+ +L C P +
Sbjct: 1180 GRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPC-PARGTPKPQV 1238
Query: 579 SWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFY 638
+W ++G E + P A + + + + S D+ + T S R +
Sbjct: 1239 TW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKL---- 1293
Query: 639 RLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSAN--PAPE------------AFNWTFR 684
V+Y P + E L + AN P PE W
Sbjct: 1294 ---VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 1350
Query: 685 GYRLSPAGGPRHRILSSG-ALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIR 743
G+ L HR+L G +LH + D GLY +N GTA+ L V P++
Sbjct: 1351 GWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVL 1410
Query: 744 ALQDPTEV--NVGGSVDIVC------------TVDANPILPGMFNWERLGEDEEDQSLDD 789
EV G V++ C T D P+LPG L E+ Q
Sbjct: 1411 GAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG---GPHLQVQEDGQV--- 1464
Query: 790 MEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKV 849
LRI + + G YQC+ + AR +L V P + +V
Sbjct: 1465 -----------LRITGSHVGDEGRYQCVAFSPAGQQARD-FQLRVHAPPTIWGSNETGEV 1512
Query: 850 AAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANV 909
A D L C ARGVP TW K+G L P T+ Y +GG L
Sbjct: 1513 AVMEDHL--VQLLCEARGVPTPNITWFKDGALL----PTSTKVVYTRGGRQLQL----GR 1562
Query: 910 SAAQDYALFTCTATNALGSDQTNIQL 935
+ + D ++TC A+NA+G+ + +L
Sbjct: 1563 AQSSDAGVYTCKASNAVGAAEKATRL 1588
Score = 116 bits (290), Expect = 2e-25
Identities = 169/628 (26%), Positives = 250/628 (39%), Gaps = 76/628 (12%)
Query: 325 AGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPM 384
AGT + VT PP ++ + + + + LSC P L W WR +LP
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAP-YNLTWVRDWR-VLPA 559
Query: 385 EETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKL 444
+ L + +S + +G C A + + S+ L V+ Q
Sbjct: 560 STGRVAQLADLSLEISGII-----PTDGGRYQCVASN---ANGVTRASVWLLVREAPQ-- 609
Query: 445 WIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEK 504
+ Q G V++ C A G P P + W ++S+ + QE R+H V+
Sbjct: 610 -VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQAL------QEDSRIH---VDA 658
Query: 505 SGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQF---PPTNVTILANASALRPGD 561
G+ L++ ++ ++C+A + Q V P +V+ + + G+
Sbjct: 659 QGT-----LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGE 713
Query: 562 ALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRV 621
L C S PP + W + G LE + AP +GS++ + + RD G
Sbjct: 714 EAVLVC-EASGVPPPRVIWYRGG--LEMILAP------EGSSSGKLRIPAAQERDAGT-Y 763
Query: 622 TCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNW 681
TCRA + EL + S+ +L V + P+ L E VT ALL + P P
Sbjct: 764 TCRAVN-ELGDA-SAEIQLAVGHAPQ-LTELPRDVTVELGRSALLACRATGRPPPTV--- 817
Query: 682 TFR-------GYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGT--AEARL 732
T+R G RL G R R SG L +V D Y +N G AEARL
Sbjct: 818 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 877
Query: 733 RLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEK 792
+ H P I + V G V + C V A LP +W + G + L +
Sbjct: 878 IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER-HWLKDG-----RPLPPGSR 931
Query: 793 ISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAA 852
S G L + A AG Y C+ N A R + LVV+ P++ HPT +
Sbjct: 932 HSIRADGSLHLDRALQEHAGRYSCVATN-TAGSQHRDVELVVQVPPRI-HPTATHHITNE 989
Query: 853 GDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAA 912
G A+L C A GVP TWTK L + P Y L IA S A
Sbjct: 990 G---VPASLPCVASGVPAPTITWTKETNALTSRGPHYNVS-------KEGTLLIAQPS-A 1038
Query: 913 QDYALFTCTATNALGSDQTNIQLVSISR 940
QD + CTATN +G ++L S++R
Sbjct: 1039 QDAGAYVCTATNTVGFSSQEMRL-SVNR 1065
Score = 115 bits (289), Expect = 2e-25
Identities = 221/931 (23%), Positives = 336/931 (36%), Gaps = 136/931 (14%)
Query: 31 PRGFWALPENLTVVEGASVELRCGVST-PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDP 89
PRG P + + + L C V P + W +DG++L D P
Sbjct: 3585 PRG----PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQF---------P 3631
Query: 90 ARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVT 149
RG F L ++A +D +Y C R+ G V+ RV I P + P V
Sbjct: 3632 ERGRF-LQLQALSTADSGDYSC-TARNAAGSTSVAFRV--EIHTVPTIRSGPPAVNVSVN 3687
Query: 150 WVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSS 209
A ++ C D PAP ++ + S E + R+ P +
Sbjct: 3688 QTA----LLPC-QADGVPAPLVSWRKDRVPLDPRSPRFE-------ILPEGSLRIQPVLA 3735
Query: 210 DNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARG 269
+ +C AS+ A + + VL PP P + A LPC A
Sbjct: 3736 QDAGHYLCLASNSA--GSDRQGRDLRVLEPPAIA----PSPSNLTLTAHTPALLPCEA-S 3788
Query: 270 GNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQE 329
G+P + W K+GQ + + + + L++T AQ C N V +
Sbjct: 3789 GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRL 3848
Query: 330 HGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVM 389
+ +T+ V PP+ + T V L+C S + P + W QL
Sbjct: 3849 YQVTVHV--PPTIADDQTDFTVTMMAPVVLTCHS-TGIPAPTVSWSKAGAQLGARGSGYR 3905
Query: 390 DGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP 449
G L A R TC A + A K + L V+ ++
Sbjct: 3906 VSPSGALEIGQALPIHAGR------YTCSARNSAGVAH---KHVFLTVQASPV---VKPL 3953
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTV----TESRLPQESRRVHLGSVEKS 505
P + A V L C A G P P++ W K+ V + LP R+ S E +
Sbjct: 3954 PSVVRAVAEEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDA 4012
Query: 506 GSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANASALRPGD 561
G+ + C AG T+L VQ PP L + S
Sbjct: 4013 GN------------------YLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSH 4054
Query: 562 ALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRV 621
A L C + S P N++WDK+G+ + G F + ++ + +D G
Sbjct: 4055 AF-LPCKARGSPEP-NITWDKDGQPVSGA-----EGKFTIQPSGELLVKNLEGQDAGT-Y 4106
Query: 622 TCRAHSAELRETVSSFYRLNVLYRPEFL---GEQVLVVTAVEQGEAL-LPVSVSANPAPE 677
TC A +A R L +L P F G++ L + G+ L L + +P P
Sbjct: 4107 TCTAENAVGR--ARRRVHLTILVLPVFTTLPGDRSLRL-----GDRLWLRCAARGSPTPR 4159
Query: 678 AFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVH 737
WT ++ + L V+R D G Y +N G +A + V
Sbjct: 4160 -IGWTVNDRPVTEGVSEQD---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 4215
Query: 738 YAPTIRA-----LQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEK 792
AP ++ L +P VGGS+ + C V +P+ +W + G L +
Sbjct: 4216 EAPVLQGEAFSYLVEP----VGGSIQLDCVVRGDPVPD--IHWIKDGLPLRGSHLRHQLQ 4269
Query: 793 ISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAP--QVEHPTPLTKVA 850
G L IH + AG YQC+ +N + A++++ LV++ AP QVE P
Sbjct: 4270 -----NGSLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAPVFQVE---PQDMTV 4320
Query: 851 AAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVS 910
+GD + L C+A G P W + G PL T + L + NV
Sbjct: 4321 RSGDDVA---LRCQATGEPTPTIEWLQAGQPLRASRRLRT--------LPDGSLWLENVE 4369
Query: 911 AAQDYALFTCTATNALGSDQTNIQLVSISRP 941
D + C A N LGS LV P
Sbjct: 4370 TG-DAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 105 bits (261), Expect = 3e-22
Identities = 242/1025 (23%), Positives = 371/1025 (36%), Gaps = 152/1025 (14%)
Query: 16 LLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKD------- 67
L E ++A+ VP P N V+E ASV L C S P V W K
Sbjct: 1870 LAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSW 1929
Query: 68 -GLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPEL---- 122
G+ + D R+ L IE LSD Y C EL
Sbjct: 1930 MGVTVSVDGRV------------------LRIEQAQLSDAGSYRCVASNVAGSTELRYGL 1971
Query: 123 ---VSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGD-AKPA--PDITILLS 176
V PR+ L +P +L+ TP T A ++ G+ PA P + +
Sbjct: 1972 RVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPG 2031
Query: 177 GQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNV 236
G+ ++ SA ++ + V A ++RQ +V + P P +NV
Sbjct: 2032 GRVLTLASARASDSGRYSCVAVSAV-------GEDRQDVVLQVHMP----PSILGEELNV 2080
Query: 237 LFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQA 296
V A +S+ L C + P L W K+G+P+ G H A
Sbjct: 2081 -----------------SVVANESVALECQSH-AMPPPVLSWWKDGRPLEPRPGV-HLSA 2121
Query: 297 VARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKN 356
+ V D G +CEA N + + + + V P + + + E
Sbjct: 2122 DKALLQVDRADVWDAG-HYTCEALNQAGHSEKHYNLNVWVA-PVFPLRESHTLTVREGHP 2179
Query: 357 VTLSCVSKS-SRPRVLLRWWLGWRQLLPMEETVMDGLHGGHIS-MSNLTFL--ARREDNG 412
+LSC + P++ W Q LP E G H+S + L +L A+ G
Sbjct: 2180 TSLSCECRGVPFPKIS---WRKDGQPLPGE-----GAGLQHVSAVGRLLYLGQAQLAQEG 2231
Query: 413 LTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNP 472
T TCE + + L L V P Q PP + L C A G P
Sbjct: 2232 -TYTCECSNVVGNS---SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKP 2286
Query: 473 EPSLMWYKDSRTVTES---RLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCK 529
P++ W +D + V +L + + +H VE++ + + V ++N
Sbjct: 2287 PPTVTWERDGQPVGAELGLQLQNQGQSLH---VERAQAAHTGRYSCV---AEN------L 2334
Query: 530 AGQLSASTQLAVQFPPT---NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGER 586
AG+ +L+V PP ++ L N +A L L C ++ PP + W + E
Sbjct: 2335 AGRAERKFELSVLVPPELIGDLDPLTNITAAL-HSPLTLLCEAMGIPPPA-IRWFRGEEP 2392
Query: 587 LEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRP 646
+ P + + + Q +D G +C A S E E +F + VL P
Sbjct: 2393 VS-----PGEDTYLLAGGWMLKMTQTQEQDSG-LYSCLA-SNEAGEARRNF-SVEVLVPP 2444
Query: 647 EFLGEQVLVVTAVEQGE-ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA-L 704
E + V V G+ A L +V+ +P P+ W G L A G H I G L
Sbjct: 2445 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK-LTWFKDGRPL--ARGDAHHISPDGVLL 2501
Query: 705 HLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTI-----RALQDPTEVNVGGSVDI 759
+ + G Y N+ G +L V APTI + + V V + +
Sbjct: 2502 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISL 2561
Query: 760 VCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVD 819
+C A P W + G E + + G L+I +A+ AG Y C+V
Sbjct: 2562 ICEALAFP--SPNITWMKDGAPFEASRNIQLLPGTHG----LQILNAQKEDAGQYTCVVT 2615
Query: 820 NGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST---SSATLHCRARGVPNIVFTWT 876
N + + + V P + PL +V T S+ TL C + VP W
Sbjct: 2616 NELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY 2674
Query: 877 KNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQ-L 935
K+G P+ T + Q LL I + D + C ATN G D + L
Sbjct: 2675 KDGQPV-------TPSSRLQVLGEGRLLQI-QPTQVSDSGRYLCVATNVAGEDDQDFNVL 2726
Query: 936 VSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVD--VVPP 993
+ + PP KV + L + GG+ + R P + Y D +PP
Sbjct: 2727 IQV----PPMFQKVGDFSAAFEILSREEEARGGVTE---YREIVENNPAYLYCDTNAIPP 2779
Query: 994 QATTF 998
T+
Sbjct: 2780 PDLTW 2784
Score = 97.4 bits (241), Expect = 7e-20
Identities = 229/1006 (22%), Positives = 350/1006 (34%), Gaps = 170/1006 (16%)
Query: 22 AQLAIPASVPRGFWALPENLTVVEGASVELRCGV--STPGSAVQWAKDGLLLGPDPRIPG 79
A+L + P + + V+EG V L C V P W KDG L P R
Sbjct: 875 ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR--- 931
Query: 80 FPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLL 139
R + LH++ Y C V + G + V L + VPP++
Sbjct: 932 --------HSIRADGSLHLDRALQEHAGRYSC-VATNTAGSQ--HRDVELVVQVPPRI-- 978
Query: 140 LTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVE 199
P A +T G + CV+ PAP IT ++ + N + L +
Sbjct: 979 -HPTATHHIT-NEGVPASLPCVASGV-PAPTITWTKETNALTSRGPHYNVSKEGTLLIAQ 1035
Query: 200 ATARVTP-----------------RSSDNRQLLV-------------------------- 216
+A+ R S NR L
Sbjct: 1036 PSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSG 1095
Query: 217 ---CEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
C AS+PA A + V V PP ++ PG V G++L+L CVA G NP
Sbjct: 1096 HYECTASNPAGSASHRYVLGVQV-----PPQVQ-PGPRVLKVLVGEALDLNCVAEG-NPE 1148
Query: 274 ATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
L W K+G + + SV +R D G + CEA NS AG +
Sbjct: 1149 PQLSWSKDGVVLQG-------RGPQGSVHFAAIRTSDAG-RYRCEASNS--AGVDAWEVE 1198
Query: 334 LQVTFPP--SAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDG 391
L+V PP A G + +N +L C ++ + P+ + W G P E + G
Sbjct: 1199 LRVLEPPHWGADETSGLLERVAGENASLPCPARGT-PKPQVTWRKG-----PSSEP-LHG 1251
Query: 392 LHGGHISMSNLTFLARRE--DNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP 449
G + FLA D+G C+A +E + K ++ Y + +G
Sbjct: 1252 QPGVAVLEEGSLFLASVSPADSG-DYECQATNEVGSTSRRAKLVV----YVPPSIREDGR 1306
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTES------------------RLP 491
AG + L C A G P P ++W KD++ V RL
Sbjct: 1307 KANVSGMAGQSLTLECDA-NGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLL 1365
Query: 492 QESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTIL 551
E + +H +++ S L + ++NQA G L V PP+ +
Sbjct: 1366 DEGQSLHFPRIQEGDSG------LYSCRAENQA------GTAQRDFHLLVLTPPSVLGAG 1413
Query: 552 ANASALR-PGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLL 610
A L G + L C + S P + W K+ + + + P + R
Sbjct: 1414 AAQEVLGLAGADVELQCWT-SGVPTPQVEWTKDRQPV--LPGGPHLQVQEDGQVLRITGS 1470
Query: 611 QVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSV 670
V Q V + R+ ++L V P G AV + + L+ +
Sbjct: 1471 HVGDEGRYQCVAFSPAGQQARD-----FQLRVHAPPTIWGSNETGEVAVME-DHLVQLLC 1524
Query: 671 SANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEA 730
A P F+ L P L L +D G+Y N+ G AE
Sbjct: 1525 EARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEK 1584
Query: 731 RLRLDVHYAPTIRALQD---PTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSL 787
RLDV+ PTI + G V + C +P ++ E L E ++S
Sbjct: 1585 ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESR 1644
Query: 788 DDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLT 847
+ + LR+ A +G Y C+ + V++++ +V+ P L
Sbjct: 1645 LETD------GSVLRLESPGEASSGLYSCVASSPAG-------EAVLQYSVEVQVPPQLL 1691
Query: 848 KVAAAGDSTS----SATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSL 903
G T+ L C+A G P W +NG P + E Q +
Sbjct: 1692 VAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAE-------ELAGVQVASQGTT 1744
Query: 904 LTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKV 949
L I +V LF C ATN G+ ++ VS+ P L+V
Sbjct: 1745 LHIDHVELDHS-GLFACQATNEAGTAGAEVE-VSVHGEWAPGVLEV 1788
Score = 93.2 bits (230), Expect = 1e-18
Identities = 196/791 (24%), Positives = 287/791 (36%), Gaps = 99/791 (12%)
Query: 58 PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYEC----QV 113
P V W KD + L DPR P F E L I+ D Y C
Sbjct: 3700 PAPLVSWRKDRVPL--DPRSPRFE--------ILPEGSLRIQPVLAQDAGHYLCLASNSA 3749
Query: 114 GRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITI 173
G G +L +L PP + + + +T A ++ C P P +
Sbjct: 3750 GSDRQGRDL-------RVLEPPAIA----PSPSNLTLTAHTPALLPC-EASGSPKPLVVW 3797
Query: 174 LLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFT 233
GQ + + +G+ +L A P D+ Q C S+ EA T
Sbjct: 3798 WKDGQKLD---FRLQQGAY-RLLPSNALLLTAPGPQDSAQF-ECVVSNEVGEAHRLYQVT 3852
Query: 234 VNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEH 293
V+V PP I D V + L C + G P T+ W K G + A G+ +
Sbjct: 3853 VHV-----PPTIADDQTDFT-VTMMAPVVLTCHSTG-IPAPTVSWSKAGAQLG-ARGSGY 3904
Query: 294 TQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTE 353
+ + ++ + P H + +C A NS AG + L V P +
Sbjct: 3905 RVSPSGALEIGQALPI-HAGRYTCSARNS--AGVAHKHVFLTVQASPVVKPLPSVVRAVA 3961
Query: 354 NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGL 413
+ V L C + S PR + W + T + L GG + +++ A ED G
Sbjct: 3962 EEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQV--LPGGQLRIAH----ASPEDAGN 4014
Query: 414 TLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPE 473
L C A + A + K L++ V P IE G+ L C A G+PE
Sbjct: 4015 YL-CIAKNSAGSAMG-KTRLVVQVP-PV----IENGLPDLSTTEGSHAFLPCKA-RGSPE 4066
Query: 474 PSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA--- 530
P++ W KD + V+ G+ K S EL++ + +TC A
Sbjct: 4067 PNITWDKDGQPVS-------------GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 4113
Query: 531 -GQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL-E 588
G+ L + P T+ + S LR GD L L C + S P + W + E
Sbjct: 4114 VGRARRRVHLTILVLPVFTTLPGDRS-LRLGDRLWLRCAARGSPTP-RIGWTVNDRPVTE 4171
Query: 589 GVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEF 648
GV+ GS R+ VS D G V C A + R SF ++V P
Sbjct: 4172 GVSEQDG-----GSTLQRAA---VSREDSGTYV-CWAENRVGRTQAVSF--VHVKEAPVL 4220
Query: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWN 708
GE + G L V +P P+ +W G L G L +G+L +
Sbjct: 4221 QGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IHWIKDGLPLR--GSHLRHQLQNGSLTIHR 4277
Query: 709 VTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPI 768
R D G YQ +N G A+ + L + AP + V G V + C P
Sbjct: 4278 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP- 4336
Query: 769 LPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARR 828
W + G Q L ++ P G L + + + AG Y C+ N + R
Sbjct: 4337 -TPTIEWLQAG-----QPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 4390
Query: 829 LLRLVVRFAPQ 839
LVVR PQ
Sbjct: 4391 AF-LVVRGEPQ 4400
Score = 84.7 bits (208), Expect = 5e-16
Identities = 188/810 (23%), Positives = 275/810 (33%), Gaps = 169/810 (20%)
Query: 217 CEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATL 276
C A S A KA V P P ++ P + V G++ L C G P L
Sbjct: 496 CTAVSRAGTGRAKAQIVVT---DPPPQLVPAPNVT---VSPGETAVLSCRVLGEAPY-NL 548
Query: 277 QWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQV 336
W+++ + + + G Q S+ + + P D G + C A N+ G + L V
Sbjct: 549 TWVRDWRVLPASTGRV-AQLADLSLEISGIIPTD-GGRYQCVASNA--NGVTRASVWLLV 604
Query: 337 TFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGH 396
P I S ++ V +SC S S P + W + L +D
Sbjct: 605 REAPQVSIHTSSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVD------ 657
Query: 397 ISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLR 456
+ L ++ +C+A +E T + L+ PP +
Sbjct: 658 -AQGTLIIQGVAPEDAGNYSCQATNEVGTDQE------------TVTLYYTDPPSVSAVN 704
Query: 457 A------GTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFS 510
A G LVC A G P P ++WY+ + + GS+ S
Sbjct: 705 AVVLVAVGEEAVLVCEA-SGVPPPRVIWYRGGLEMI---------------LAPEGSS-S 747
Query: 511 RELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQFPPTNVTILANASALRPGDALNLT 566
+L + + +TC+A G SA QLAV P +T L + G + L
Sbjct: 748 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-QLTELPRDVTVELGRSALLA 806
Query: 567 CVSVSSNPPVNLSWDKE-----GERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRV 621
C + PP ++W + G RL R P G SV + D V
Sbjct: 807 C-RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESV----APEDQAPYV 861
Query: 622 TCRAHSAELRETVSSFYRLNVL-YRPEFLGEQVLVVTAVEQGEALLPVSVSAN-PAPEAF 679
C A + + V + RL V + P + V +E LP V A P PE
Sbjct: 862 -CEARNVFGK--VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER- 917
Query: 680 NWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYA 739
+W G L P G RH I + G+LHL + G Y N+ G+ + L V
Sbjct: 918 HWLKDGRPLPP--GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP 975
Query: 740 PTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGP-- 797
P I N G + C P W + E +L SRGP
Sbjct: 976 PRIHPTATHHITNEGVPASLPCVASGVP--APTITWTK-----ETNAL-----TSRGPHY 1023
Query: 798 ----TGRLRIHHAKLAQAGAYQCIVDNGVAPPARRL------------------------ 829
G L I AGAY C N V ++ +
Sbjct: 1024 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGS 1083
Query: 830 LRLV----------------------------VRFAPQVEHPTPLTKVAAAGDSTSSATL 861
LRL V+ PQV+ P P G++ L
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQ-PGPRVLKVLVGEALD---L 1139
Query: 862 HCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCT 921
+C A G P +W+K+GV L + P QG VH + + D + C
Sbjct: 1140 NCVAEGNPEPQLSWSKDGVVLQGRGP--------QGSVHFAAI------RTSDAGRYRCE 1185
Query: 922 ATNALGSDQTNIQLVSISRP----DPPSGL 947
A+N+ G D ++L + P D SGL
Sbjct: 1186 ASNSAGVDAWEVELRVLEPPHWGADETSGL 1215
Score = 74.3 bits (181), Expect = 7e-13
Identities = 138/540 (25%), Positives = 203/540 (37%), Gaps = 78/540 (14%)
Query: 414 TLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPE 473
T C A S A T K+ I+ P Q + P + G L C +G P
Sbjct: 493 TYECTAVSRAGTGRA--KAQIVVTDPPPQLV----PAPNVTVSPGETAVLSCRVLGEAPY 546
Query: 474 PSLMWYKDSRTVTESRLPQESRRV-HLG--SVEKSGSTFSRELVLVTGPSDNQAKFTCKA 530
+L W +D R LP + RV L S+E SG ++ T Q +
Sbjct: 547 -NLTWVRDWRV-----LPASTGRVAQLADLSLEISG-------IIPTDGGRYQCVASNAN 593
Query: 531 GQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGV 590
G AS L V+ P V+I ++ G + ++C S S P ++SW +E + L+
Sbjct: 594 GVTRASVWLLVREAP-QVSIHTSSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQ-- 649
Query: 591 AAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHS--AELRETVSSFYRLNVLYRPEF 648
+ A ++ V+ D G +C+A + +ETV+ +Y P
Sbjct: 650 ----EDSRIHVDAQGTLIIQGVAPEDAGN-YSCQATNEVGTDQETVTLYYT----DPPSV 700
Query: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYR--LSPAGGPRHRILSSGALHL 706
+V+ AV + EA+L S P P W G L+P G SSG L +
Sbjct: 701 SAVNAVVLVAVGE-EAVLVCEASGVPPPRVI-WYRGGLEMILAPEGS------SSGKLRI 752
Query: 707 WNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDAN 766
D G Y N G A A ++L V +AP + L V +G S + C
Sbjct: 753 PAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGR 812
Query: 767 PILPGMFNWERLGEDEEDQSLDDMEKISRG------PTGRLRIHHAKLAQAGAYQCIVDN 820
P P W R + Q L RG +G L Y C N
Sbjct: 813 P--PPTVTWRR----GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866
Query: 821 GVAPPARRLLRLVV--RFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKN 878
V + RL+V PQ+ P +V G S + R +P W K+
Sbjct: 867 -VFGKVQAEARLIVTGHAPPQIASSAPTVRV-LEGQPVSLPCIVLAGRPLPE--RHWLKD 922
Query: 879 GVPLDLQDPRYTEHTYH-QGGVHSSLLTIANVSAAQDYA-LFTCTATNALGSDQTNIQLV 936
G PL P + H+ G +H A Q++A ++C ATN GS +++LV
Sbjct: 923 GRPL----PPGSRHSIRADGSLHLD-------RALQEHAGRYSCVATNTAGSQHRDVELV 971
Score = 50.4 bits (119), Expect = 1e-05
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 707 WNVTRA---DDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTV 763
W + RA ++G Y+ + GT A+ ++ V P V+ G + + C V
Sbjct: 481 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV 540
Query: 764 DANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGR--------LRIHHAKLAQAGAYQ 815
LGE + + ++ TGR L I G YQ
Sbjct: 541 --------------LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 586
Query: 816 CIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTW 875
C+ N R + L+VR APQV T + + S C A G P +W
Sbjct: 587 CVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS----CSASGYPTPHISW 641
Query: 876 TKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
++ L +D R H QG L I V A +D ++C ATN +G+DQ +
Sbjct: 642 SRESQALQ-EDSRI--HVDAQG-----TLIIQGV-APEDAGNYSCQATNEVGTDQ---ET 689
Query: 936 VSISRPDPPSGLKVVSLTPHSVGLE 960
V++ DPPS V ++ +VG E
Sbjct: 690 VTLYYTDPPSVSAVNAVVLVAVGEE 714
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 161 bits (408), Expect = 3e-39
Identities = 265/967 (27%), Positives = 375/967 (38%), Gaps = 134/967 (13%)
Query: 21 LAQLAIPA--SVPRGFWALPENLTVVE-GASVELRCGVST-PGSAVQWAKDGLLLGPDPR 76
L+ L PA PRG P++ +V G L C P V W KDG L R
Sbjct: 1741 LSVLVPPAFRQAPRG----PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 1796
Query: 77 IPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPK 136
RG L I+ +SD Y C+V S + E V L++ VPP
Sbjct: 1797 TQAL----------RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRT-FTLTVQVPPT 1843
Query: 137 LLLLTPEAGTMVTWVAGQEYVVNC-VSGDAKPAPDITILLSGQTI--SDISANVNEGSQQ 193
P+ T V+ VAG V+ C VSG PAP +T L + S + V+ G +
Sbjct: 1844 FE--NPKTET-VSQVAGSPLVLTCDVSG--VPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1898
Query: 194 KLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLD-E 252
+L +R+ P + C A + EA + F V VL P I G+ E
Sbjct: 1899 QL------SRLQPAQAGT---YTCVAENTQAEA--RKDFVVAVLVAPR---IRSSGVARE 1944
Query: 253 GHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMT-VRPEDH 311
HV GQ + L C A G P + WLK+G P+ G + LV+ +R D
Sbjct: 1945 HHVLEGQEVRLDCEA-DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2003
Query: 312 GAQLSCEAHNSVSAGTQEHGITLQVTFPPS---AIIILGSASQTENKNVTLSCVSKSSRP 368
GA +C AHN + H T+ V PP+ G+ + VT+ C + S P
Sbjct: 2004 GAY-TCVAHNPAGEDARLH--TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2060
Query: 369 RVLLRWWLGWRQLLPMEETVMDGLHG-GHISMSNLTFLARREDNGLTLTCEAFSEAFTKE 427
+ WL LP+ + + LHG GH + LA D G+ TC A S A +
Sbjct: 2061 IHVS--WLKDGLPLPLSQRTL--LHGSGHTLRISKVQLA---DAGI-FTCVAASPAGVAD 2112
Query: 428 TFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE 487
++ L V+ P +E + +R G+ V L C A G P P + W KD +
Sbjct: 2113 ---RNFTLQVQVPPVLEPVEFQNDVVVVR-GSLVELPCEA-RGVPLPLVSWMKDGEPLLS 2167
Query: 488 SRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPP-T 546
L Q G + E V +AG+ QL V PP
Sbjct: 2168 QSLEQ-------------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHI 2214
Query: 547 NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAAR 606
+ +L PG + L C P N++W K+G+ L + S A R
Sbjct: 2215 EDSGQPTELSLTPGAPMELLC-DAQGTPQPNITWHKDGQALTRLE--------NNSRATR 2265
Query: 607 SVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQ-VLVVTAVEQGEAL 665
+L+V RD G TC A S + +R+ V P +G + V + G+ +
Sbjct: 2266 --VLRV--RDAGL-YTCLAESPA--GAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV 2318
Query: 666 LPVSVSANPAPEAFNWTFRGYRLSPAGGP----RHRILSSGALHLWNVTRADDGLYQLHC 721
L SV A PAP+ W G L R R L AL + AD G Y
Sbjct: 2319 LECSVEAEPAPK-ITWHRDGIVLQEDAHTQFPERGRFLQLQAL-----STADSGDYSCTA 2372
Query: 722 QNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGED 781
+N+ G+ R+++H PTIR+ V+V + + C D P + +R+ D
Sbjct: 2373 RNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD 2432
Query: 782 EEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPAR-RLLRLVVRFAPQV 840
+ + P G LRI AG Y C+ N + R LR++ P
Sbjct: 2433 PRSPRFEIL------PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL---EPPA 2483
Query: 841 EHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH 900
P+P A + A L C A G P + W K+G LD R + Y +
Sbjct: 2484 IAPSPSNLTLTA---HTPALLPCEASGSPKPLVVWWKDGQKLDF---RLQQGAYRLLPSN 2537
Query: 901 SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP---DPPSGLKV-----VSL 952
+ LLT QD A F C +N +G Q+ P D + V V L
Sbjct: 2538 ALLLT---APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVL 2594
Query: 953 TPHSVGL 959
T HS G+
Sbjct: 2595 TCHSTGI 2601
Score = 158 bits (399), Expect = 3e-38
Identities = 227/882 (25%), Positives = 343/882 (38%), Gaps = 125/882 (14%)
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQE 155
L IE DL D+ Y C + + E V L +LVPP + E G + V
Sbjct: 568 LQIEKVDLRDEGIYTCAA--TNLAGES-KREVALKVLVPPNI-----EPGPVNKAVLENA 619
Query: 156 YVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLL 215
V P PD++ Q +S V ++ +E A+++ S
Sbjct: 620 SVTLECLASGVPPPDVSWFKGHQPVSSWMG-VTVSVDGRVLRIEQ-AQLSDAGSYR---- 673
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLAT 275
C AS+ A ++ VNV PP I P G V + L C A G P T
Sbjct: 674 -CVASNVAGSTELRYGLRVNV-----PPRITLPPSLPGPVLVNTPVRLTCNATGA-PSPT 726
Query: 276 LQWLKNGQPVSTAWGTEHTQAV--ARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
L WLK+G PVS A GT Q R + + + R D G + SC A ++V Q+ +
Sbjct: 727 LMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSG-RYSCVAVSAVGEDRQD--VV 782
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
LQV PPS + + S N++V L C S + P V L WW R L P
Sbjct: 783 LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKDGRPLEPRP-------- 833
Query: 394 GGHISMSNLTFLARRED--NGLTLTCEAFSEA-FTKETFKKSLILNVKYPAQKLWIEGPP 450
G H+S R D + TCEA ++A +++ + ++ + +P ++
Sbjct: 834 GVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRE------S 887
Query: 451 EGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFS 510
+R G RL C G P P + W KD + LP E G+ + S
Sbjct: 888 HTLTVREGHPTRLSC-ECRGVPFPKISWRKDGQP-----LPGE------GAGLQHVSAVG 935
Query: 511 RELVLVTGPSDNQAKFTCK----AGQLSASTQLAVQF---------PPTNVTILANASAL 557
R L L + +TC+ G S QL V PPT V+++ + A
Sbjct: 936 RLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA- 994
Query: 558 RPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDH 617
L C + + PP ++W+++G+ + + +S+ ++ + H
Sbjct: 995 ------TLEC-NATGKPPPTVTWERDGQPVGA------ELGLQLQNQGQSLHVERAQAAH 1041
Query: 618 GQRVTCRAHSAELRETVSSFYRLNVLYRPEFLG--EQVLVVTAVEQGEALLPVSVSANPA 675
R +C A + L + L+VL PE +G + + +TA L P
Sbjct: 1042 TGRYSCVAEN--LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIP- 1098
Query: 676 PEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLD 735
P A W FRG G + + L + D GLY N G A ++
Sbjct: 1099 PPAIRW-FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 1157
Query: 736 VHYAPTI--RALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKI 793
V P+I L++ +V G + ++C V +P W + D + D I
Sbjct: 1158 VLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP--QPKLTWFK---DGRPLARGDAHHI 1212
Query: 794 SRGPTG-RLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAA 852
S P G L++ A L+ AG Y CI N V + +L V A PT L +
Sbjct: 1213 S--PDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH-FQLSVLLA-----PTILGGAEDS 1264
Query: 853 GDSTSSATLH------CRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTI 906
D + T++ C A P+ TW K+G P + + + G H L I
Sbjct: 1265 ADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA-----SRNIQLLPGTHG--LQI 1317
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQL-----VSISRPDP 943
N + +D +TC TN LG N + SIS+ DP
Sbjct: 1318 LN-AQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDP 1358
Score = 149 bits (377), Expect = 1e-35
Identities = 260/1068 (24%), Positives = 395/1068 (36%), Gaps = 168/1068 (15%)
Query: 31 PRGFWALPEN--LTVVEGASVELRC---GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRL 85
P W E + V+E V+L C GV TP + W KDG LL ++
Sbjct: 218 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN--ITWFKDGALLPTSTKVVY------ 269
Query: 86 EGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAG 145
RG L + SD Y C+ + E + L + VPP + AG
Sbjct: 270 ----TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR---LDVYVPPTI----EGAG 318
Query: 146 T---MVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATA 202
+V VAG+ + CV+ P+P ++ G ++ E ++ +L T +
Sbjct: 319 GRPYVVKAVAGRPVALECVAR-GHPSPTLSWHHEGLPVA-------ESNESRLETDGSVL 370
Query: 203 RVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLE 262
R+ + L C ASSPA EA ++ ++V V PP V E GL + GQ LE
Sbjct: 371 RLESPGEASSGLYSCVASSPAGEAVLQ--YSVEVQVPPQLLVAE--GLGQVTTIVGQPLE 426
Query: 263 LPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNS 322
LPC A G+P+ T+QWL+NG+P G + A + L + DH +C+A N
Sbjct: 427 LPCQA-SGSPVPTIQWLQNGRPAEELAGVQ--VASQGTTLHIDHVELDHSGLFACQATNE 483
Query: 323 VSAGTQEHGITLQVTFPPSAI-IILGSA--SQTENKNVTLSCVSKSSR-------PRVLL 372
E +++ + P + + +G + + +C R P ++
Sbjct: 484 AGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 543
Query: 373 RW------WLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTK 426
W W G +P+ ++ L + + D G+ TC A + A
Sbjct: 544 GWCSPGSLW-GEPTGIPVAYSLPPPLQIEKVDL---------RDEGI-YTCAATNLAGES 592
Query: 427 ETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVT 486
K+ + L V P IE P + + V L CLA G P P + W+K + V+
Sbjct: 593 ---KREVALKVLVPPN---IEPGPVNKAVLENASVTLECLA-SGVPPPDVSWFKGHQPVS 645
Query: 487 ESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQ----LAVQ 542
+ + S R L + + + C A ++ ST+ L V
Sbjct: 646 -------------SWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 692
Query: 543 FPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGS 602
PP + + + LTC + + P L W K+G + P + F G
Sbjct: 693 VPPRITLPPSLPGPVLVNTPVRLTC-NATGAPSPTLMWLKDGNPVSPAGTPGLQV-FPG- 749
Query: 603 AAARSVLLQVSSRDHGQRVTCRAHSA--ELRETVSSFYRLNVLYRPEFLGEQVLVVTAVE 660
R + L + R +C A SA E R+ V L V P LGE+ L V+ V
Sbjct: 750 --GRVLTLASARASDSGRYSCVAVSAVGEDRQDVV----LQVHMPPSILGEE-LNVSVVA 802
Query: 661 QGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLH 720
L A P P +W G L P G H L + D G Y
Sbjct: 803 NESVALECQSHAMP-PPVLSWWKDGRPLEPRPGV-HLSADKALLQVDRADVWDAGHYTCE 860
Query: 721 CQNSEGTAEARLRLDVHYAPTIRALQDPT-EVNVGGSVDIVCTVDANPILPGMFNWERLG 779
N G +E L+V AP + T V G + C P +W + G
Sbjct: 861 ALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPF--PKISWRKDG 918
Query: 780 E--DEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFA 837
+ E L + + R L + A+LAQ G Y C N V ++ L+L V
Sbjct: 919 QPLPGEGAGLQHVSAVGR----LLYLGQAQLAQEGTYTCECSNVVGNSSQD-LQLEVHVP 973
Query: 838 PQVEHP-TPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVP------LDLQDPRYT 890
PQ+ P P T+V+ D ATL C A G P TW ++G P L LQ+ +
Sbjct: 974 PQIAGPREPPTQVSVVQDGV--ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS 1031
Query: 891 EHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVV 950
H H+ ++C A N G + +L V
Sbjct: 1032 LHVERAQAAHT--------------GRYSCVAENLAGRAERKFEL-------------SV 1064
Query: 951 SLTPHSVG-LEWKPGFDGGLPQRFCIRYEALGTP-----GFHYVDVVPPQATTFTLTG-- 1002
+ P +G L+ L + EA+G P F + V P T+ L G
Sbjct: 1065 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW 1124
Query: 1003 ---LQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPED 1047
+ + L + A ++G A + + + P PS E ED
Sbjct: 1125 MLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP----PSIENED 1168
Score = 139 bits (350), Expect = 2e-32
Identities = 240/929 (25%), Positives = 354/929 (38%), Gaps = 114/929 (12%)
Query: 56 STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGR 115
+ P ++W KDG + P R+ RL L I+ +SD Y C V
Sbjct: 1383 AVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVSDSGRYLC-VAT 1431
Query: 116 SEMGPELVSPRVILSILVPP------------KLLLLTPEAGTMVTWVAGQEYVVN---- 159
+ G + V++ VPP ++L EA VT +E V N
Sbjct: 1432 NVAGEDDQDFNVLIQ--VPPMFQKVGDFSAAFEILSREEEARGGVTEY--REIVENNPAY 1487
Query: 160 -CVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCE 218
+A P PD+T Q +S G + + ++ ++N C+
Sbjct: 1488 LYCDTNAIPPPDLTWYREDQPLS-------AGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1540
Query: 219 ASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQW 278
AS+ E + + + VL PP ++E V A ++ L C A G NP+ T+ W
Sbjct: 1541 ASNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALG-NPVPTISW 1597
Query: 279 LKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTF 338
L+NG P S + + + VL ++ A C A N AG+ E TL+V
Sbjct: 1598 LQNGLPFSPSPRLQVLE--DGQVLQVSTAEVADAASYMCVAEN--QAGSAEKLFTLRVQV 1653
Query: 339 PPS-AIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHI 397
PP A + L + N +V+L C + P + W+ + L EE + L G H
Sbjct: 1654 PPRIAGLDLEQVTAILNSSVSLPC-DVHAHPNPEVTWYKDSQALSLGEEVFL--LPGTHT 1710
Query: 398 SMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRA 457
AR D+G+ TCEA + A + + +L PA + GP + +R
Sbjct: 1711 LQLG---RARLSDSGM-YTCEALNAAGRDQKLVQLSVL--VPPAFRQAPRGPQDAVLVRV 1764
Query: 458 GTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVT 517
G + L C PEP++ WYKD + + ++ Q R G + V+
Sbjct: 1765 GDKAVLSC-ETDALPEPTVTWYKDGQPLVLAQRTQALR---------GGQRLEIQEAQVS 1814
Query: 518 GPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVN 577
K + AG+ + L VQ PPT + G L LTC VS P
Sbjct: 1815 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTC-DVSGVPAPT 1873
Query: 578 LSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSF 637
++W K+ +E A +R LQ+S Q T + +
Sbjct: 1874 VTWLKDRMPVESSAV--------HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKD 1925
Query: 638 YRLNVLYRPEFLGEQVLVVTAVEQG-EALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRH 696
+ + VL P V V +G E L P P+ W G L GP
Sbjct: 1926 FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDV-AWLKDGSPLGQDMGPHL 1984
Query: 697 RI-LSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLR-LDVHYAPTIRALQDPTEVNV- 753
R L G+L L + +D G Y N G +ARL ++V PTI+ D + V
Sbjct: 1985 RFYLDGGSLVLKGLRASDAGAYTCVAHNPAG-EDARLHTVNVLVPPTIKQGADGSGTLVS 2043
Query: 754 --GGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQA 811
G V +VC V +P P +W + G + G LRI +LA A
Sbjct: 2044 RPGELVTMVCPVRGSP--PIHVSWLKDGLPLP----LSQRTLLHGSGHTLRISKVQLADA 2097
Query: 812 GAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST----SSATLHCRARG 867
G + C+ A PA R F QV+ P L V D S L C ARG
Sbjct: 2098 GIFTCV----AASPAGVADR---NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARG 2150
Query: 868 VPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG 927
VP + +W K+G PL + QG L + V A D ++C A + G
Sbjct: 2151 VPLPLVSWMKDGEPL-------LSQSLEQG----PSLQLEAVGAG-DSGTYSCVAVSEAG 2198
Query: 928 SDQTNIQLVSISRPD-PPSGLKV-VSLTP 954
+ + QL + P SG +SLTP
Sbjct: 2199 EARRHFQLTVMEPPHIEDSGQPTELSLTP 2227
Score = 131 bits (329), Expect = 5e-30
Identities = 229/942 (24%), Positives = 361/942 (38%), Gaps = 120/942 (12%)
Query: 37 LPENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFH 95
L E +TV ++V L+C + P + W ++GL P PR+ ++
Sbjct: 1569 LVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQV---------- 1618
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQE 155
L + +++D A Y C V ++ G L + VPP++ L E VT +
Sbjct: 1619 LQVSTAEVADAASYMC-VAENQAGS--AEKLFTLRVQVPPRIAGLDLE---QVTAILNSS 1672
Query: 156 YVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLL 215
+ C A P P++T Q +S G + L T ++ + +
Sbjct: 1673 VSLPC-DVHAHPNPEVTWYKDSQALS-------LGEEVFLLPGTHTLQLGRARLSDSGMY 1724
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLAT 275
CEA + A + ++VL PP D VR G L C P T
Sbjct: 1725 TCEALNAA--GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC-ETDALPEPT 1781
Query: 276 LQWLKNGQPVSTAWGTEHTQAV--ARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
+ W K+GQP+ A + TQA+ + + + + D G SC+ N + +T
Sbjct: 1782 VTWYKDGQPLVLA---QRTQALRGGQRLEIQEAQVSDKGL-YSCKVSNVAGEAVRTFTLT 1837
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSC-VSKSSRPRVLLRWWLGWRQLLPMEETVMDGL 392
+QV P + SQ + L+C VS P V WL + +P+E + + G+
Sbjct: 1838 VQVP-PTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVT---WL--KDRMPVESSAVHGV 1891
Query: 393 --HGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPP 450
GG + +S L + T TC A + T+ +K ++ V A ++ G
Sbjct: 1892 VSRGGRLQLSRL-----QPAQAGTYTCVAEN---TQAEARKDFVVAV-LVAPRIRSSGVA 1942
Query: 451 EGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFS 510
+ G VRL C A G P P + W KD + + P HL GS
Sbjct: 1943 REHHVLEGQEVRLDCEA-DGQPPPDVAWLKDGSPLGQDMGP------HLRFYLDGGS--- 1992
Query: 511 RELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANASAL--RPGDALN 564
LVL + + +TC AG+ + + V PPT + L RPG+ +
Sbjct: 1993 --LVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVT 2050
Query: 565 LTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCR 624
+ C V +PP+++SW K+G L +R GS + +V D G
Sbjct: 2051 MVC-PVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRI-SKVQLADAGIFTCVA 2104
Query: 625 AHSAEL--RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWT 682
A A + R VL EF + V+V ++ + LP P P +W
Sbjct: 2105 ASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVE----LPCEARGVPLP-LVSWM 2159
Query: 683 FRGYRL---SPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYA 739
G L S GP +L L V D G Y + G A +L V
Sbjct: 2160 KDGEPLLSQSLEQGP--------SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEP 2211
Query: 740 PTIRALQDPTEVNV--GGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGP 797
P I PTE+++ G ++++C P W + G Q+L +E SR
Sbjct: 2212 PHIEDSGQPTELSLTPGAPMELLCDAQGTP--QPNITWHKDG-----QALTRLENNSRA- 2263
Query: 798 TGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTS 857
T LR+ AG Y C+ ++ A + R+ V+ P + P V G +
Sbjct: 2264 TRVLRVR-----DAGLYTCLAES-PAGAIEKSFRVRVQAPPNIVGPRGPRFV--VGLAPG 2315
Query: 858 SATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYAL 917
L C P TW ++G+ L E + Q L + +S A D
Sbjct: 2316 QLVLECSVEAEPAPKITWHRDGIVLQ-------EDAHTQFPERGRFLQLQALSTA-DSGD 2367
Query: 918 FTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGL 959
++CTA NA GS ++ + P SG V+++ + L
Sbjct: 2368 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTAL 2409
Score = 130 bits (328), Expect = 6e-30
Identities = 237/932 (25%), Positives = 359/932 (38%), Gaps = 125/932 (13%)
Query: 43 VVEGASVELRCGVS-TPGSAVQWAKDGLLLGPD--PRIPGFPRYRLEGDPARGEFHLHIE 99
V+EG V L C P V W KDG LG D P + R+ L+G L ++
Sbjct: 1947 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHL----RFYLDGGS------LVLK 1996
Query: 100 ACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVN 159
SD Y C V + G + V ++LVPP + +GT+V+ +V
Sbjct: 1997 GLRASDAGAYTC-VAHNPAGEDARLHTV--NVLVPPTIKQGADGSGTLVSRPGELVTMVC 2053
Query: 160 CVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEA 219
V G P ++ L G + + GS T R++ + + C A
Sbjct: 2054 PVRGS--PPIHVSWLKDGLPLPLSQRTLLHGSGH-------TLRISKVQLADAGIFTCVA 2104
Query: 220 SSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWL 279
+SPA A +FT+ V PP +E+ ++ V G +ELPC ARG PL + W+
Sbjct: 2105 ASPAGVAD--RNFTLQVQVPPVLEPVEFQ--NDVVVVRGSLVELPCEARGV-PLPLVSWM 2159
Query: 280 KNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFP 339
K+G+P+ + + S+ + V D G SC A + AG L V P
Sbjct: 2160 KDGEPLLS-----QSLEQGPSLQLEAVGAGDSGTY-SCVAVSE--AGEARRHFQLTVMEP 2211
Query: 340 PSAIIILGSASQTE-----NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHG 394
P I S TE + L C ++ + P+ + W + L +E
Sbjct: 2212 PH---IEDSGQPTELSLTPGAPMELLCDAQGT-PQPNITWHKDGQALTRLENN------- 2260
Query: 395 GHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQK 454
S T + R D GL TC A S A E KS + V+ P + GP
Sbjct: 2261 -----SRATRVLRVRDAGL-YTCLAESPAGAIE---KSFRVRVQAPPNIVGPRGPRFVVG 2311
Query: 455 LRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE---SRLPQESRRVHLGSVEKSGSTFSR 511
L G V L C ++ P P + W++D + E ++ P+ R + L ++ + S
Sbjct: 2312 LAPGQLV-LEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGD-- 2367
Query: 512 ELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
+ + N A T A ++ T ++ P V + N +AL P A +
Sbjct: 2368 ----YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV------ 2417
Query: 572 SNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELR 631
P +SW K+ L+ PR F+ + V ++D G + ++SA
Sbjct: 2418 --PAPLVSWRKDRVPLD-----PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2470
Query: 632 ETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFR---GYRL 688
L VL P + +T ALLP S +P P W +RL
Sbjct: 2471 RQGRD---LRVL-EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2526
Query: 689 SPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDP 748
+R+L S AL L D ++ N G A ++ VH PTI D
Sbjct: 2527 QQGA---YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIA--DDQ 2581
Query: 749 TEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKL 808
T+ V +V T + I +W + G + ++S P+G L I A
Sbjct: 2582 TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG--YRVS--PSGALEIGQALP 2637
Query: 809 AQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGV 868
AG Y C N A A + + L V+ +P V+ PL V A + L C A G+
Sbjct: 2638 IHAGRYTCSARNS-AGVAHKHVFLTVQASPVVK---PLPSVVRAV-AEEEVLLPCEASGI 2692
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAA----QDYALFTCTATN 924
P TW K G+ + GV + +L + A +D + C A N
Sbjct: 2693 PRPTITWQKEGLNVAT-------------GVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 2739
Query: 925 ALGSDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
+ GS +LV P +GL +S T S
Sbjct: 2740 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGS 2771
Score = 126 bits (316), Expect = 1e-28
Identities = 232/913 (25%), Positives = 356/913 (38%), Gaps = 128/913 (14%)
Query: 46 GASVELRCGV-STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLS 104
G V + C V +P V W KDGL L P R L G L I L+
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLLHGSGHT----LRISKVQLA 2095
Query: 105 DDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGD 164
D + C V S G + L + VPP +L E V V G + C +
Sbjct: 2096 DAGIFTC-VAASPAG--VADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARG 2150
Query: 165 AKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPAL 224
P P ++ + G+ + +S ++ +G +L V A T C A S A
Sbjct: 2151 V-PLPLVSWMKDGEPL--LSQSLEQGPSLQLEAVGAGDSGT---------YSCVAVSEAG 2198
Query: 225 EAPIKASFTVNVLFPPGPPVIEWPGLD-EGHVRAGQSLELPCVARGGNPLATLQWLKNGQ 283
EA + F + V+ PP IE G E + G +EL C A+G P + W K+GQ
Sbjct: 2199 EA--RRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQG-TPQPNITWHKDGQ 2252
Query: 284 PVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAI 343
++ + +R+ V+ VR D G +C A + AG E ++V PP+ +
Sbjct: 2253 ALT------RLENNSRATRVLRVR--DAGLY-TCLAESP--AGAIEKSFRVRVQAPPNIV 2301
Query: 344 ------IILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGL--HGG 395
++G A + L C S + P + W R + ++E G
Sbjct: 2302 GPRGPRFVVGLAPG----QLVLEC-SVEAEPAPKITWH---RDGIVLQEDAHTQFPERGR 2353
Query: 396 HISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKL 455
+ + L+ D+G +C A + A + S+ V+ GPP +
Sbjct: 2354 FLQLQALS----TADSG-DYSCTARNAAGST-----SVAFRVEIHTVPTIRSGPP-AVNV 2402
Query: 456 RAGTRVRLVCLAIGGNPEPSLMWYKDS-----RTVTESRLPQESRRVHLGSVEKSGSTFS 510
L C A G P P + W KD R+ LP+ S R+ + +G
Sbjct: 2403 SVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLC 2461
Query: 511 RELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSV 570
L + SD Q + L A+ P+N+T+ A+ AL P +A
Sbjct: 2462 --LASNSAGSDRQGR------DLRVLEPPAIAPSPSNLTLTAHTPALLPCEA-------- 2505
Query: 571 SSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAEL 630
S +P + W K+G++L+ +A +LL + C S E+
Sbjct: 2506 SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA----LLLTAPGPQDSAQFECVV-SNEV 2560
Query: 631 RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSP 690
E Y++ V P +Q T +L + PAP +W+ G +L
Sbjct: 2561 GEA-HRLYQVTVHVPPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTV-SWSKAGAQLG- 2616
Query: 691 AGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTE 750
A G +R+ SGAL + G Y +NS G A + L V +P ++ L P+
Sbjct: 2617 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPL--PSV 2674
Query: 751 VNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRG--PTGRLRIHHAKL 808
V +++ +A+ I W++ G L+ +S P G+LRI HA
Sbjct: 2675 VRAVAEEEVLLPCEASGIPRPTITWQKEG-------LNVATGVSTQVLPGGQLRIAHASP 2727
Query: 809 AQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGV 868
AG Y CI N A A RLVV+ P +E+ P S A L C+ARG
Sbjct: 2728 EDAGNYLCIAKNS-AGSAMGKTRLVVQVPPVIENGLPDLSTTEG----SHAFLPCKARGS 2782
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGS 928
P TW K+G P+ + ++T S L + N+ QD +TCTA NA+G
Sbjct: 2783 PEPNITWDKDGQPVSGAEGKFTIQP-------SGELLVKNLE-GQDAGTYTCTAENAVGR 2834
Query: 929 DQTNIQLVSISRP 941
+ + L + P
Sbjct: 2835 ARRRVHLTILVLP 2847
Score = 112 bits (281), Expect = 2e-24
Identities = 220/931 (23%), Positives = 335/931 (35%), Gaps = 136/931 (14%)
Query: 31 PRGFWALPENLTVVEGASVELRCGVST-PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDP 89
PRG P + + + L C V P + W +DG++L D P
Sbjct: 2303 PRG----PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQF---------P 2349
Query: 90 ARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVT 149
RG F L ++A +D +Y C R+ G V+ RV I P + P V
Sbjct: 2350 ERGRF-LQLQALSTADSGDYSC-TARNAAGSTSVAFRV--EIHTVPTIRSGPPAVNVSVN 2405
Query: 150 WVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSS 209
A ++ C D PAP ++ + S E + R+ P +
Sbjct: 2406 QTA----LLPC-QADGVPAPLVSWRKDRVPLDPRSPRFE-------ILPEGSLRIQPVLA 2453
Query: 210 DNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARG 269
+ +C AS+ A + + VL PP P + A LPC A
Sbjct: 2454 QDAGHYLCLASNSA--GSDRQGRDLRVLEPPAIA----PSPSNLTLTAHTPALLPCEA-S 2506
Query: 270 GNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQE 329
G+P + W K+GQ + + + + L++T AQ C N V +
Sbjct: 2507 GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRL 2566
Query: 330 HGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVM 389
+ +T+ V PP+ + T V L+C S + P + W QL
Sbjct: 2567 YQVTVHV--PPTIADDQTDFTVTMMAPVVLTCHS-TGIPAPTVSWSKAGAQLGARGSGYR 2623
Query: 390 DGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP 449
G L A R TC A + A K + L V+ ++
Sbjct: 2624 VSPSGALEIGQALPIHAGR------YTCSARNSAGVAH---KHVFLTVQASPV---VKPL 2671
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTV----TESRLPQESRRVHLGSVEKS 505
P + A V L C A G P P++ W K+ V + LP R+ S E +
Sbjct: 2672 PSVVRAVAEEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDA 2730
Query: 506 GSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANASALRPGD 561
G+ + C AG T+L VQ PP L + S
Sbjct: 2731 GN------------------YLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSH 2772
Query: 562 ALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRV 621
A L C + S P N++WDK+G+ + G F + ++ + +D G
Sbjct: 2773 AF-LPCKARGSPEP-NITWDKDGQPVSGA-----EGKFTIQPSGELLVKNLEGQDAGT-Y 2824
Query: 622 TCRAHSAELRETVSSFYRLNVLYRPEFL---GEQVLVVTAVEQGEAL-LPVSVSANPAPE 677
TC A +A R L +L P F G++ L + G+ L L + +P P
Sbjct: 2825 TCTAENAVGR--ARRRVHLTILVLPVFTTLPGDRSLRL-----GDRLWLRCAARGSPTPR 2877
Query: 678 AFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVH 737
WT ++ + L V+R D G Y +N G +A + V
Sbjct: 2878 -IGWTVNDRPVTEGVSEQD---GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 2933
Query: 738 YAPTIRA-----LQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEK 792
AP ++ L +P VGGS+ + C V +P+ +W + G L +
Sbjct: 2934 EAPVLQGEAFSYLVEP----VGGSIQLDCVVRGDPVPD--IHWIKDGLPLRGSHLRHQLQ 2987
Query: 793 ISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAP--QVEHPTPLTKVA 850
G L I + AG YQC+ +N + A++++ LV++ AP QVE P
Sbjct: 2988 -----NGSLTIRRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAPVFQVE---PQDMTV 3038
Query: 851 AAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVS 910
+GD + L C+A G P W + G PL T + L + NV
Sbjct: 3039 RSGDDVA---LRCQATGEPTPTIEWLQAGQPLRASRRLRT--------LPDGSLWLENVE 3087
Query: 911 AAQDYALFTCTATNALGSDQTNIQLVSISRP 941
D + C A N LGS LV P
Sbjct: 3088 TG-DAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 105 bits (261), Expect = 3e-22
Identities = 242/1025 (23%), Positives = 370/1025 (36%), Gaps = 152/1025 (14%)
Query: 16 LLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKD------- 67
L E ++A+ VP P N V+E ASV L C S P V W K
Sbjct: 588 LAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSW 647
Query: 68 -GLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPEL---- 122
G+ + D R+ L IE LSD Y C EL
Sbjct: 648 MGVTVSVDGRV------------------LRIEQAQLSDAGSYRCVASNVAGSTELRYGL 689
Query: 123 ---VSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGD-AKPA--PDITILLS 176
V PR+ L +P +L+ TP T A ++ G+ PA P + +
Sbjct: 690 RVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPG 749
Query: 177 GQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNV 236
G+ ++ SA ++ + V A ++RQ +V + P P +NV
Sbjct: 750 GRVLTLASARASDSGRYSCVAVSAV-------GEDRQDVVLQVHMP----PSILGEELNV 798
Query: 237 LFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQA 296
V A +S+ L C + P L W K+G+P+ G H A
Sbjct: 799 -----------------SVVANESVALECQSH-AMPPPVLSWWKDGRPLEPRPGV-HLSA 839
Query: 297 VARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKN 356
+ V D G +CEA N + + + + V P + + + E
Sbjct: 840 DKALLQVDRADVWDAG-HYTCEALNQAGHSEKHYNLNVWVA-PVFPLRESHTLTVREGHP 897
Query: 357 VTLSCVSKS-SRPRVLLRWWLGWRQLLPMEETVMDGLHGGHIS-MSNLTFL--ARREDNG 412
LSC + P++ W Q LP E G H+S + L +L A+ G
Sbjct: 898 TRLSCECRGVPFPKIS---WRKDGQPLPGE-----GAGLQHVSAVGRLLYLGQAQLAQEG 949
Query: 413 LTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNP 472
T TCE + + L L V P Q PP + L C A G P
Sbjct: 950 -TYTCECSNVVGNS---SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKP 1004
Query: 473 EPSLMWYKDSRTVTES---RLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCK 529
P++ W +D + V +L + + +H VE++ + + V ++N
Sbjct: 1005 PPTVTWERDGQPVGAELGLQLQNQGQSLH---VERAQAAHTGRYSCV---AEN------L 1052
Query: 530 AGQLSASTQLAVQFPPT---NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGER 586
AG+ +L+V PP ++ L N +A L L C ++ PP + W + E
Sbjct: 1053 AGRAERKFELSVLVPPELIGDLDPLTNITAAL-HSPLTLLCEAMGIPPPA-IRWFRGEEP 1110
Query: 587 LEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRP 646
+ P + + + Q +D G +C A S E E +F + VL P
Sbjct: 1111 VS-----PGEDTYLLAGGWMLKMTQTQEQDSG-LYSCLA-SNEAGEARRNF-SVEVLVPP 1162
Query: 647 EFLGEQVLVVTAVEQGE-ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA-L 704
E + V V G+ A L +V+ +P P+ W G L A G H I G L
Sbjct: 1163 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK-LTWFKDGRPL--ARGDAHHISPDGVLL 1219
Query: 705 HLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTI-----RALQDPTEVNVGGSVDI 759
+ + G Y N+ G +L V APTI + + V V + +
Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISL 1279
Query: 760 VCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVD 819
+C A P W + G E + + G L+I +A+ AG Y C+V
Sbjct: 1280 ICEALAFP--SPNITWMKDGAPFEASRNIQLLPGTHG----LQILNAQKEDAGQYTCVVT 1333
Query: 820 NGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST---SSATLHCRARGVPNIVFTWT 876
N + + + V P + PL +V T S+ TL C + VP W
Sbjct: 1334 NELGEAVKN-YHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY 1392
Query: 877 KNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQ-L 935
K+G P+ T + Q LL I + D + C ATN G D + L
Sbjct: 1393 KDGQPV-------TPSSRLQVLGEGRLLQI-QPTQVSDSGRYLCVATNVAGEDDQDFNVL 1444
Query: 936 VSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVD--VVPP 993
+ + PP KV + L + GG+ + R P + Y D +PP
Sbjct: 1445 IQV----PPMFQKVGDFSAAFEILSREEEARGGVTE---YREIVENNPAYLYCDTNAIPP 1497
Query: 994 QATTF 998
T+
Sbjct: 1498 PDLTW 1502
Score = 97.4 bits (241), Expect = 7e-20
Identities = 213/844 (25%), Positives = 304/844 (36%), Gaps = 178/844 (21%)
Query: 257 AGQSLELPCVARGGNPLATLQWLKNGQPVST-----------AWGTEHTQAV---ARSVL 302
AGQSL L C A G P+ + WLK+ Q V WG + +S+
Sbjct: 32 AGQSLTLECDA-NGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLH 90
Query: 303 VMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTE-----NKNV 357
++ D G SC A N AGT + L V PPS +LG+ + E +V
Sbjct: 91 FPRIQEGDSGL-YSCRAEN--QAGTAQRDFHLLVLTPPS---VLGAGAAQEVLGLAGADV 144
Query: 358 TLSCVSKSSRPRVLLRWWLGWRQLLP-------MEETVMDGLHGGHISMSNLTFLARRED 410
L C + S P + W + +LP E+ + + G H+ D
Sbjct: 145 ELQCWT-SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG-----------D 192
Query: 411 NGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGG 470
G C AFS A + + L V P +W + V+L+C A G
Sbjct: 193 EG-RYQCVAFSPAGQQ---ARDFQLRVHAP-PTIWGSNETGEVAVMEDHLVQLLCEA-RG 246
Query: 471 NPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA 530
P P++ W+KD + LP ++ V+ + R+L L S + +TCKA
Sbjct: 247 VPTPNITWFKDG-----ALLPTSTKVVY--------TRGGRQLQLGRAQSSDAGVYTCKA 293
Query: 531 ----GQLSASTQLAVQFPPT-----NVTILANASALRPGDALNLTCVSVSSNPPVNLSWD 581
G +T+L V PPT + A A RP + L CV+ +P LSW
Sbjct: 294 SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP---VALECVA-RGHPSPTLSWH 349
Query: 582 KEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLN 641
EG L + R GS + SS + + A A L+ Y +
Sbjct: 350 HEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ------YSVE 401
Query: 642 VLYRPEFLGEQVLVVTAVEQGEAL-LPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILS 700
V P+ L + L G+ L LP S +P P W G G ++ S
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP-TIQWLQNGRPAEELAGV--QVAS 458
Query: 701 SG-ALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVH--YAPTIRALQDPTEVNVG--- 754
G LH+ +V GL+ N GTA A + + VH +AP + EV +G
Sbjct: 459 QGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGV------LEVPIGQYH 512
Query: 755 ------GSVDIVCTV------DANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTG--- 799
S C A+P P + W G + PTG
Sbjct: 513 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG------------SLWGEPTGIPV 560
Query: 800 ------RLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAG 853
L+I L G Y C N +A ++R + L V P +E P P+ K
Sbjct: 561 AYSLPPPLQIEKVDLRDEGIYTCAATN-LAGESKREVALKVLVPPNIE-PGPVNKAVL-- 616
Query: 854 DSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQ 913
+S TL C A GVP +W K P+ + G S + + AQ
Sbjct: 617 -ENASVTLECLASGVPPPDVSWFKGHQPV----------SSWMGVTVSVDGRVLRIEQAQ 665
Query: 914 --DYALFTCTATNALGSDQTNIQL---------VSISRPDPPSGLKVVSLTPHSVG---- 958
D + C A+N GS + L + S P P V LT ++ G
Sbjct: 666 LSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSP 725
Query: 959 -LEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASN 1017
L W G P GTPG V P TL + S R +A +
Sbjct: 726 TLMW---LKDGNP------VSPAGTPGLQ----VFPGGRVLTLASARASDSGRYSCVAVS 772
Query: 1018 ALGD 1021
A+G+
Sbjct: 773 AVGE 776
Score = 92.8 bits (229), Expect = 2e-18
Identities = 196/791 (24%), Positives = 287/791 (36%), Gaps = 99/791 (12%)
Query: 58 PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYEC----QV 113
P V W KD + L DPR P F E L I+ D Y C
Sbjct: 2418 PAPLVSWRKDRVPL--DPRSPRFE--------ILPEGSLRIQPVLAQDAGHYLCLASNSA 2467
Query: 114 GRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITI 173
G G +L +L PP + + + +T A ++ C P P +
Sbjct: 2468 GSDRQGRDL-------RVLEPPAIA----PSPSNLTLTAHTPALLPC-EASGSPKPLVVW 2515
Query: 174 LLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFT 233
GQ + + +G+ +L A P D+ Q C S+ EA T
Sbjct: 2516 WKDGQKLD---FRLQQGAY-RLLPSNALLLTAPGPQDSAQF-ECVVSNEVGEAHRLYQVT 2570
Query: 234 VNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEH 293
V+V PP I D V + L C + G P T+ W K G + A G+ +
Sbjct: 2571 VHV-----PPTIADDQTDFT-VTMMAPVVLTCHSTG-IPAPTVSWSKAGAQLG-ARGSGY 2622
Query: 294 TQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTE 353
+ + ++ + P H + +C A NS AG + L V P +
Sbjct: 2623 RVSPSGALEIGQALPI-HAGRYTCSARNS--AGVAHKHVFLTVQASPVVKPLPSVVRAVA 2679
Query: 354 NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGL 413
+ V L C + S PR + W + T + L GG + +++ A ED G
Sbjct: 2680 EEEVLLPCEA-SGIPRPTITWQKEGLNVATGVSTQV--LPGGQLRIAH----ASPEDAGN 2732
Query: 414 TLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPE 473
L C A + A + K L++ V P IE G+ L C A G+PE
Sbjct: 2733 YL-CIAKNSAGSAMG-KTRLVVQVP-PV----IENGLPDLSTTEGSHAFLPCKA-RGSPE 2784
Query: 474 PSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA--- 530
P++ W KD + V+ G+ K S EL++ + +TC A
Sbjct: 2785 PNITWDKDGQPVS-------------GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2831
Query: 531 -GQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL-E 588
G+ L + P T+ + S LR GD L L C + S P + W + E
Sbjct: 2832 VGRARRRVHLTILVLPVFTTLPGDRS-LRLGDRLWLRCAARGSPTP-RIGWTVNDRPVTE 2889
Query: 589 GVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEF 648
GV+ GS R+ VS D G V C A + R SF ++V P
Sbjct: 2890 GVSEQDG-----GSTLQRAA---VSREDSGTYV-CWAENRVGRTQAVSF--VHVKEAPVL 2938
Query: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWN 708
GE + G L V +P P+ +W G L G L +G+L +
Sbjct: 2939 QGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IHWIKDGLPLR--GSHLRHQLQNGSLTIRR 2995
Query: 709 VTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPI 768
R D G YQ +N G A+ + L + AP + V G V + C P
Sbjct: 2996 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP- 3054
Query: 769 LPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARR 828
W + G Q L ++ P G L + + + AG Y C+ N + R
Sbjct: 3055 -TPTIEWLQAG-----QPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3108
Query: 829 LLRLVVRFAPQ 839
LVVR PQ
Sbjct: 3109 AF-LVVRGEPQ 3118
Score = 31.2 bits (69), Expect = 6.4
Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 11/103 (10%)
Query: 848 KVAAAGDSTSSATLHCRARGVPNIVFTWTKN----GVPLDLQDPRYTEHTYHQGGVHSSL 903
K +G + S TL C A G P W K+ GVPL + + + Q G H L
Sbjct: 25 KANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGW-DLGWGQVGGHRLL 83
Query: 904 -----LTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
L + D L++C A N G+ Q + L+ ++ P
Sbjct: 84 DEGQSLHFPRIQEG-DSGLYSCRAENQAGTAQRDFHLLVLTPP 125
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 156 bits (394), Expect = 1e-37
Identities = 248/919 (26%), Positives = 362/919 (39%), Gaps = 115/919 (12%)
Query: 33 GFWALPENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPAR 91
G A P N VV S+ L C P + W KDG+ + + I R+E
Sbjct: 1643 GNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNI------RIEA---- 1692
Query: 92 GEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTW- 150
G L I + D +Y C V S G + + V +LVPP + E G ++
Sbjct: 1693 GGKKLEIMSAQEIDRGQYIC-VATSVAGEKEIKYEV--DVLVPPAI-----EGGDETSYF 1744
Query: 151 --VAGQEYVVNC-VSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPR 207
+ ++C V+G P P I L GQ I + + +KL +A
Sbjct: 1745 IVMVNNLLELDCHVTGS--PPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQV----- 1797
Query: 208 SSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVA 267
N L C A++ A + + TV+V PP I+ GL E V + + L C+A
Sbjct: 1798 --SNTGLYRCMAANTAGDHKKEFEVTVHV-----PPTIKSSGLSERVVVKYKPVALQCIA 1850
Query: 268 RGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGT 327
G P ++ WLK+ QPV+TA G Q+ R + + ED G + +C A N +AG
Sbjct: 1851 NG-IPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAG-RYTCVATN--AAGE 1906
Query: 328 QEHGITLQVTFPPSAIIILGSASQTENKNVTLSC-----VSKSSRPRVLLRWWLGWRQLL 382
+ I L V PPS L A + N+ V +S + P ++ W+ R L
Sbjct: 1907 TQQHIQLHVHEPPS----LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLL- 1961
Query: 383 PMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQ 442
T M L+ G I A+ D G+ C A + A E F SL ++V P+
Sbjct: 1962 -SGSTSMTFLNRGQIIDIE---SAQISDAGI-YKCVAINSAGATELF-YSLQVHVA-PS- 2013
Query: 443 KLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSV 502
I G + VRL C A G P PSL W KD V+ G
Sbjct: 2014 ---ISGSNNMVAVVVNNPVRLECEA-RGIPAPSLTWLKDGSPVSS---------FSNGLQ 2060
Query: 503 EKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANASALR 558
SG R L L + + ++TC AG+ L V PP + N S L
Sbjct: 2061 VLSG---GRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVL- 2116
Query: 559 PGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL-LQVSSRDH 617
A+ L C S + PP L+W K+G P + P + RSVL ++ +
Sbjct: 2117 ISQAVELLCQS-DAIPPPTLTWLKDGH-------PLLKKPGLSISENRSVLKIEDAQVQD 2168
Query: 618 GQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPE 677
R TC A + Y +N+ P G L V +G + + S+ P
Sbjct: 2169 TGRYTCEA--TNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPP 2226
Query: 678 AFNWTFRGYRLSPAGGPRHRILSSG-ALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV 736
W +G + R RILS G L + ++D LY N GTA+ L V
Sbjct: 2227 NLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQV 2286
Query: 737 HYAPTI-RALQDPTEVNV--GGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKI 793
+ PTI + PTE+ V G S+ + C V P P W + G +E +
Sbjct: 2287 YIRPTITNSGSHPTEIIVTRGKSISLECEVQGIP--PPTVTWMKDGHPL--IKAKGVEIL 2342
Query: 794 SRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQV--EHPTPLTKVAA 851
G L++ + ++ G Y C+ N VA + L V P + H +P
Sbjct: 2343 DEGHI--LQLKNIHVSDTGRYVCVAVN-VAGMTDKKYDLSVHAPPSIIGNHRSPENISVV 2399
Query: 852 AGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSA 911
+S S L C A G+P TW K+G P+ L + GG L+ +
Sbjct: 2400 EKNSVS---LTCEASGIPLPSITWFKDGWPVSLSN----SVRILSGGRMLRLMQ----TT 2448
Query: 912 AQDYALFTCTATNALGSDQ 930
+D +TC NA G ++
Sbjct: 2449 MEDAGQYTCVVRNAAGEER 2467
Score = 150 bits (379), Expect = 7e-36
Identities = 230/930 (24%), Positives = 367/930 (39%), Gaps = 130/930 (13%)
Query: 38 PENLTVVEGASVELRCGV--STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFH 95
P V+EG + L C + P +W K+ +L +P I R +
Sbjct: 896 PSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYIT-----------VRSDGS 944
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMV-TWVAGQ 154
LHIE L D EY C V + G + V++ +L T + G + + + G
Sbjct: 945 LHIERVQLQDGGEYTC-VASNVAGTNNKTTSVVVHVLP-------TIQHGQQILSTIEGI 996
Query: 155 EYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQL 214
+ C P P + G+ IS SA + G+ L+ V +P ++ +
Sbjct: 997 PVTLPC-KASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVV------SPGGEESGEY 1049
Query: 215 LVCEASSPALEAPIKASFTVNVLFPPGPPVI-EWPGLDEGH-----VRAGQSLELPCVAR 268
VC A++ A A K TV V P V + GL + V AG+ + LPC +
Sbjct: 1050 -VCTATNTAGYAKRKVQLTVYVR----PRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVK 1104
Query: 269 GGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQ 328
P + W K Q +S + HT + S+ + R D G L C A N AG
Sbjct: 1105 SLPP-PIITWAKETQLISP-FSPRHTFLPSGSMKITETRTSDSGMYL-CVATNI--AGNV 1159
Query: 329 EHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETV 388
+ L V PP + V + C ++ + P ++ W G +L
Sbjct: 1160 TQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGT-PLPVITWSKGGSTML------ 1212
Query: 389 MDGLHGGHISMSNLTFL---ARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLW 445
+DG H H+S + T A D G+ TC A + A T ET + L+V+ P
Sbjct: 1213 VDGEH--HVSNPDGTLSIDQATPSDAGI-YTCVATNIAGTDET---EITLHVQEPPTVED 1266
Query: 446 IEGPPEG--QKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVE 503
+E P Q+ A R+ C A G P+P++ W + R +T R P S +
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPA-KGTPKPTIKWLHNGRELT-GREPGIS-------IL 1317
Query: 504 KSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPP--------TNVTIL 551
+ G+ ++ P DN ++ C +AG L V PP TNV++L
Sbjct: 1318 EDGTLL---VIASVTPYDN-GEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVL 1373
Query: 552 ANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQ 611
N NL C V P + W K+ ++ + + + + L
Sbjct: 1374 LN-------QLTNLFC-EVEGTPSPIIMWYKDNVQVT------ESSTIQTVNNGKILKLF 1419
Query: 612 VSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVL-VVTAVEQGEALLPVSV 670
++ + R +C+A + T ++ ++VL P +G V+ V + L V
Sbjct: 1420 RATPEDAGRYSCKA--INIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV 1477
Query: 671 SANPAPEAFNWTFRGYRLSPAGGPRHRILSSG-ALHLWNVTRADDGLYQLHCQNSEGTAE 729
P P+ +W G L G P +L G LHL N R D G YQ N+ G
Sbjct: 1478 KGTPFPD-IHWFKDGKPLF-LGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQA 1535
Query: 730 ARLRLDVHYAPTIRALQDPTEVNV--GGSVDIVCTVDANPILPGMFNWERLGEDEEDQSL 787
++L ++ P+I+ T+++V + + C P +P + W + G+ S
Sbjct: 1536 KDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP-MPAI-TWYKDGQPIMSSS- 1592
Query: 788 DDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEH--PTP 845
I +G L I A+++ + Y C V N VA A + + V P +E TP
Sbjct: 1593 -QALYIDKGQY--LHIPRAQVSDSATYTCHVAN-VAGTAEKSFHVDVYVPPMIEGNLATP 1648
Query: 846 LTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLT 905
L K S TL C+A G P+ + TW K+GVP+ D E GG +++
Sbjct: 1649 LNKQVVIAHSL---TLECKAAGNPSPILTWLKDGVPVKANDNIRIE----AGGKKLEIMS 1701
Query: 906 IANVSAAQDYALFTCTATNALGSDQTNIQL 935
+ Q + C AT+ G + ++
Sbjct: 1702 AQEIDRGQ----YICVATSVAGEKEIKYEV 1727
Score = 142 bits (358), Expect = 2e-33
Identities = 227/940 (24%), Positives = 348/940 (37%), Gaps = 118/940 (12%)
Query: 20 GLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPG 79
G AQ S P +P N+TV G L C + SAV + D R+
Sbjct: 508 GRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLII---SAVDYNLTWQRNDRDVRLAE 564
Query: 80 FPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLL 139
R R L +++ +D EY C V SE G S V L++ PPK+ +
Sbjct: 565 PARIR-----TLANLSLELKSVKFNDAGEYHCMVS-SEGGSSAAS--VFLTVQEPPKVTV 616
Query: 140 LTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVE 199
+ ++ G E + C S P P I T++D+ GS + T +
Sbjct: 617 MPKNQ----SFTGGSEVSIMC-SATGYPKPKIA-----WTVNDMFI---VGSHRYRMTSD 663
Query: 200 ATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQ 259
T + + + + C AS+ A K + T+ + P V++ E V G
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSA--GTDKQNSTLRYIEAPKLMVVQ----SELLVALGD 717
Query: 260 SLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDH---GAQLS 316
+ C G P ++W K + + T + +L + E +
Sbjct: 718 ITVMECKT-SGIPPPQVKWFKGDLELRPS-----TFLIIDPLLGLLKIQETQDLDAGDYT 771
Query: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376
C A N T + ITL V PP I S NVTL C + P ++W
Sbjct: 772 CVAINEAGRATGK--ITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGY-PEPTIKW-- 826
Query: 377 GWRQL-------LPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETF 429
R+L P + + L G + + NL D G T CEA ++ ++
Sbjct: 827 --RRLDNMPIFSRPFSVSSISQLRTGALFILNLW----ASDKG-TYICEAENQFGKIQSE 879
Query: 430 KKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR 489
+ + P I P + G ++ L C + GNP P W K+S + ++
Sbjct: 880 TTVTVTGLVAPL----IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNP 935
Query: 490 LPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSAS----TQLAVQFPP 545
+V GS + L G ++TC A ++ + T + V P
Sbjct: 936 YI---------TVRSDGSLHIERVQLQDG-----GEYTCVASNVAGTNNKTTSVVVHVLP 981
Query: 546 TNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAA 605
T S + G + L C S NP ++ W K+GE + +A K SA A
Sbjct: 982 TIQHGQQILSTIE-GIPVTLPC-KASGNPKPSVIWSKKGELISTSSA-------KFSAGA 1032
Query: 606 RSVLLQVS--SRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQ-------VLVV 656
L VS + G+ V ++A + +L V RP G+Q + +
Sbjct: 1033 DGSLYVVSPGGEESGEYVCTATNTAGYAKRK---VQLTVYVRPRVFGDQRGLSQDKPVEI 1089
Query: 657 TAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGL 716
+ + E LP V + P P W +SP PRH L SG++ + +D G+
Sbjct: 1090 SVLAGEEVTLPCEVKSLPPP-IITWAKETQLISPFS-PRHTFLPSGSMKITETRTSDSGM 1147
Query: 717 YQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWE 776
Y N G ++L+VH P I+ +V VG VDI C P+ + W
Sbjct: 1148 YLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL--PVITWS 1205
Query: 777 RLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRF 836
+ G L D E P G L I A + AG Y C+ N +A + L V+
Sbjct: 1206 KGG----STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATN-IAGTDETEITLHVQE 1260
Query: 837 APQVEH-PTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYH 895
P VE P + C A+G P W NG L ++P +
Sbjct: 1261 PPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGIS--ILE 1318
Query: 896 QGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
G +LL IA+V+ D + C A N G+ + L
Sbjct: 1319 DG----TLLVIASVT-PYDNGEYICVAVNEAGTTERKYNL 1353
Score = 130 bits (326), Expect = 1e-29
Identities = 228/962 (23%), Positives = 362/962 (37%), Gaps = 143/962 (14%)
Query: 38 PENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
PE++TV+ + L C S P + + W KDG L + I P R L
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRT----------L 2631
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPP---KLLLLTPEAGTMVTWVAG 153
I + Y C V +E G + V + +PP K L P +
Sbjct: 2632 QILNAQEDNAGRYSC-VATNEAGEMIKHYEV--KVYIPPIINKGDLWGPGLSPKEVKIKV 2688
Query: 154 QEYVVNCVSGDAKPAPDITILLSGQTI-SDISANVNEGS---QQKLFTVEATARVTPRSS 209
+ A P+ ++ GQ + SD N+ Q K + T R T
Sbjct: 2689 NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYT---- 2744
Query: 210 DNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPG--LDEGH------VRAGQSL 261
C AS+ A E + F VN+ PP + G LD G V +
Sbjct: 2745 -------CVASNIAGEDEL--DFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 262 ELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHN 321
L C P TL W K+G P++++ R + + + ED G + +C A N
Sbjct: 2796 SLYCETNAAPP-PTLTWYKDGHPLTSSDKVLILPG-GRVLQIPRAKVEDAG-RYTCVAVN 2852
Query: 322 SVSAGTQEHGITLQVTFPPSAIIILGSASQTE-------NKNVTLSCVSKSSRPRVLLRW 374
+ ++ + +V PP II G+ S NK+ + C+S S P W
Sbjct: 2853 EAGEDSLQYDV--RVLVPP---IIKGANSDLPEEVTVLVNKSALIECLSSGS-PAPRNSW 2906
Query: 375 WLGWRQLLPMEETVMDGLHGGHISM---SNLTFLARREDNGLTLTCEAFSEAFTKETFKK 431
+ LL E+ L G I + +T + R C A + T + KK
Sbjct: 2907 QKDGQPLL--EDDHHKFLSNGRILQILNTQITDIGR-------YVCVAEN---TAGSAKK 2954
Query: 432 SLILNVKYPAQKLWIEGPP-EGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRL 490
LNV P + GP E + + L C + G P P L W K+ + +
Sbjct: 2955 YFNLNVHVPPSVI---GPKSENLTVVVNNFISLTC-EVSGFPPPDLSWLKNEQPI----- 3005
Query: 491 PQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPT 546
+++ ++ G R L ++ + ++TC +AG+ L V PP+
Sbjct: 3006 -----KLNTNTLIVPGG---RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 547 ---NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSA 603
+ + + +R G +++L C S + PPV ++W K G +
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPV-ITWYKNGRMITESTHV--------EI 3108
Query: 604 AARSVLLQVSSR---DHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVE 660
A +L + D GQ V CRA + R+ + + LNV P G + V+
Sbjct: 3109 LADGQMLHIKKAEVSDTGQYV-CRAINVAGRDDKN--FHLNVYVPPSIEGPEREVIVETI 3165
Query: 661 QGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA-LHLWNVTRADDGLYQL 719
L + P P W R+ + RILS G+ L + +D G Y
Sbjct: 3166 SNPVTLTCDATGIPPP-TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTC 3224
Query: 720 HCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNV--GGSVDIVCTVDANPILPGMFNWER 777
N EG A+ L + P++ + P++V+V G +V++VC +AN I + W +
Sbjct: 3225 IASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVC--NANGIPTPLIQWLK 3282
Query: 778 LGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFA 837
G+ + + + G T L I+ A + G Y C+ N A R+ L V
Sbjct: 3283 DGKPIASGETERIRVSANGST--LNIYGALTSDTGKYTCVATNP-AGEEDRIFNLNVYVT 3339
Query: 838 PQVE-HPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQ 896
P + + K+ D+ S + CRA G P W KNG+PL L
Sbjct: 3340 PTIRGNKDEAEKLMTLVDT--SINIECRATGTPPPQINWLKNGLPLPLSS---------- 3387
Query: 897 GGVHSSLLTIANV-----SAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVS 951
H LL V + D A++TC A+N G D + L + P+ + +
Sbjct: 3388 ---HIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEE 3444
Query: 952 LT 953
+T
Sbjct: 3445 IT 3446
Score = 129 bits (324), Expect = 2e-29
Identities = 211/936 (22%), Positives = 363/936 (38%), Gaps = 121/936 (12%)
Query: 38 PENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
P+ + + ++ L C + P +++ W KDG L D + + A L
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHV----------NIAANGHTL 2730
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQ-- 154
I+ +SD Y C EL ++I VPP L + T G+
Sbjct: 2731 QIKEAQISDTGRYTCVASNIAGEDELDFD---VNIQVPPSFQKLWEIGNMLDTGRNGEAK 2787
Query: 155 EYVVN------CVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRS 208
+ ++N C + +A P P +T G ++ S + L PR+
Sbjct: 2788 DVIINNPISLYCET-NAAPPPTLTWYKDGHPLTS--------SDKVLILPGGRVLQIPRA 2838
Query: 209 S-DNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLD---EGHVRAGQSLELP 264
++ C A + A E ++ + V VL PP +I+ D E V +S +
Sbjct: 2839 KVEDAGRYTCVAVNEAGEDSLQ--YDVRVLVPP---IIKGANSDLPEEVTVLVNKSALIE 2893
Query: 265 CVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVA--RSVLVMTVRPEDHGAQLSCEAHNS 322
C++ G+P W K+GQP+ +H + ++ R + ++ + D G + C A N+
Sbjct: 2894 CLS-SGSPAPRNSWQKDGQPLLE---DDHHKFLSNGRILQILNTQITDIGRYV-CVAENT 2948
Query: 323 VSAGTQEHGITLQVTFPPSAIIILGSASQT----ENKNVTLSCVSKSSRPRVLLRWWLGW 378
AG+ + L V PPS ++G S+ N ++L+C P L WL
Sbjct: 2949 --AGSAKKYFNLNVHVPPS---VIGPKSENLTVVVNNFISLTCEVSGFPPPDLS--WLKN 3001
Query: 379 RQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVK 438
Q + + + + GG L + + +G TC A ++A E+ KK +
Sbjct: 3002 EQPIKLNTNTLI-VPGGR----TLQIIRAKVSDGGEYTCIAINQA--GESKKKFSLTVYV 3054
Query: 439 YPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTES---RLPQESR 495
P+ K +R GT V L C + P P + WYK+ R +TES + + +
Sbjct: 3055 PPSIKDHDSESLSVVNVREGTSVSLECES-NAVPPPVITWYKNGRMITESTHVEILADGQ 3113
Query: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQFPPTNVTIL 551
+H+ E S + ++ C+A G+ + L V PP+
Sbjct: 3114 MLHIKKAEVSDT----------------GQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE 3157
Query: 552 ANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQ 611
+ + LTC + PP ++W K +R+E + R GS LQ
Sbjct: 3158 REVIVETISNPVTLTC-DATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSK------LQ 3210
Query: 612 VSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEAL-LPVSV 670
++ H ++ + +Y L++ P G ++ +V GE + L +
Sbjct: 3211 IARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNA 3270
Query: 671 SANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA-LHLWNVTRADDGLYQLHCQNSEGTAE 729
+ P P W G ++ R R+ ++G+ L+++ +D G Y N G +
Sbjct: 3271 NGIPTP-LIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEED 3329
Query: 730 ARLRLDVHYAPTIRALQDPTE---VNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQS 786
L+V+ PTIR +D E V S++I C P P NW + G S
Sbjct: 3330 RIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTP--PPQINWLKNGLPLPLSS 3387
Query: 787 LDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPL 846
+ ++ G +RI A+++ Y C+ N + L V P +++
Sbjct: 3388 --HIRLLAAGQV--IRIVRAQVSDVAVYTCVASNRAGVDNKHY-NLQVFAPPNMDNSMGT 3442
Query: 847 TKVAAA-GDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLT 905
++ G STS A C G P W ++G PL L D T T H +L
Sbjct: 3443 EEITVLKGSSTSMA---CITDGTPAPSMAWLRDGQPLGL-DAHLTVST------HGMVLQ 3492
Query: 906 IANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
+ + +D +TC A+N G + L + P
Sbjct: 3493 LLK-AETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527
Score = 127 bits (318), Expect = 9e-29
Identities = 214/936 (22%), Positives = 359/936 (38%), Gaps = 146/936 (15%)
Query: 38 PENLTVVEGASVELRCGV-STPGSAVQWAKDGLLLGP-DPRIPGFPRYRLEGDPARGEFH 95
P ++V+ G V L C V S P + WAK+ L+ P PR P ++ R
Sbjct: 1086 PVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETR---- 1141
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQE 155
SD Y C V + G V+ V L++ VPPK+ V GQ
Sbjct: 1142 -------TSDSGMYLC-VATNIAGN--VTQAVKLNVHVPPKIQRGPKHLKVQV----GQR 1187
Query: 156 YVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLL 215
+ C + P P IT G T+ + + + T + + + +
Sbjct: 1188 VDIPC-NAQGTPLPVITWSKGGSTML-------VDGEHHVSNPDGTLSIDQATPSDAGIY 1239
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVR-AGQSLELPCVARGGNPLA 274
C A++ A + T++V PP +E P R A Q +E PC A+G P
Sbjct: 1240 TCVATNIA--GTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKG-TPKP 1296
Query: 275 TLQWLKNGQPVSTAWGTEHTQAVARS---VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHG 331
T++WL NG+ ++ G E ++ +++ +V P D+G + C A N AGT E
Sbjct: 1297 TIKWLHNGRELT---GREPGISILEDGTLLVIASVTPYDNGEYI-CVAVNE--AGTTERK 1350
Query: 332 ITLQVTFPPSAIIILGSASQTENKNVTLSCVSK-----SSRPRVLLRWWLGWRQLLPMEE 386
L+V PP ++ Q N +V L+ ++ P ++ W+ Q+ E
Sbjct: 1351 YNLKVHVPP----VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT--ES 1404
Query: 387 TVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWI 446
+ + ++ G I F A ED G +C+A + A T + K ++V P +
Sbjct: 1405 STIQTVNNGKILK---LFRATPEDAG-RYSCKAINIAGTSQ---KYFNIDVLVPPTIIGT 1457
Query: 447 EGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSG 506
P E + V L C + G P P + W+KD + + LG
Sbjct: 1458 NFPNEVSVV-LNRDVALEC-QVKGTPFPDIHWFKDGKPL------------FLGDPNVEL 1503
Query: 507 STFSRELVLVTGPSDNQAKFTCK----AGQLSASTQLAVQFPP--------TNVTILANA 554
+ L L +++ ++ C AG+ + +L + PP T++++L N+
Sbjct: 1504 LDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINS 1563
Query: 555 SALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAA----RSVLL 610
+ L C + P ++W K+G+ P S+ A + L
Sbjct: 1564 -------LIKLECETRGLPMPA-ITWYKDGQ------------PIMSSSQALYIDKGQYL 1603
Query: 611 QVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEF-------LGEQVLVVTAVEQGE 663
+ T H A + T + ++V P L +QV++ ++
Sbjct: 1604 HIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLT--- 1660
Query: 664 ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA-LHLWNVTRADDGLYQLHCQ 722
L + NP+P W G + RI + G L + + D G Y
Sbjct: 1661 --LECKAAGNPSP-ILTWLKDGVPVK--ANDNIRIEAGGKKLEIMSAQEIDRGQYICVAT 1715
Query: 723 NSEGTAEARLRLDVHYAPTIRALQDPTE--VNVGGSVDIVCTVDANPILPGMFNWERLGE 780
+ G E + +DV P I + + V V +++ C V +P P W + G
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP--PPTIMWLKDG- 1772
Query: 781 DEEDQSLDDMEKISRGPTGR-LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQ 839
Q +D+ + GR L I A+++ G Y+C+ N A ++ + V P
Sbjct: 1773 ----QLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAAN-TAGDHKKEFEVTVHVPPT 1827
Query: 840 VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGV 899
++ +V L C A G+PN TW K+ P++ +
Sbjct: 1828 IKSSGLSERVVV---KYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQS------ 1878
Query: 900 HSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
+L IA + +D +TC ATNA G Q +IQL
Sbjct: 1879 SGRVLQIAK-TLLEDAGRYTCVATNAAGETQQHIQL 1913
Score = 121 bits (304), Expect = 4e-27
Identities = 221/935 (23%), Positives = 357/935 (38%), Gaps = 135/935 (14%)
Query: 38 PENLTVVEGASVELRCGVS-TPGSAVQWAKDG--LLLGPDPRIPGFPRYRLEGDPARGEF 94
P ++VV V L C V TP + W KDG L LG DP + R ++
Sbjct: 1460 PNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQV--------- 1509
Query: 95 HLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQ 154
LH++ +D Y+C V + G + + + L+I +PP + + G + T ++
Sbjct: 1510 -LHLKNARRNDKGRYQCTVSNAA-GKQ--AKDIKLTIYIPPSI-----KGGNVTTDIS-- 1558
Query: 155 EYVVNCV-----SGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSS 209
++N + P P IT GQ I S Q L+ + PR+
Sbjct: 1559 -VLINSLIKLECETRGLPMPAITWYKDGQPIMS--------SSQALYIDKGQYLHIPRAQ 1609
Query: 210 -DNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVAR 268
+ C ++ A A + SF V+V PP L++ V A SL L C A
Sbjct: 1610 VSDSATYTCHVANVAGTA--EKSFHVDVYVPPMIEGNLATPLNKQVVIA-HSLTLECKA- 1665
Query: 269 GGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQ 328
GNP L WLK+G PV A +A + + +M+ + D G Q C A + AG +
Sbjct: 1666 AGNPSPILTWLKDGVPVK-ANDNIRIEAGGKKLEIMSAQEIDRG-QYICVATSV--AGEK 1721
Query: 329 EHGITLQVTFPPSAIIILGSASQTE------NKNVTLSCVSKSSRPRVLLRWWLGWRQLL 382
E + V PP+ + +T N + L C S P ++ WL QL+
Sbjct: 1722 EIKYEVDVLVPPA----IEGGDETSYFIVMVNNLLELDCHVTGSPPPTIM--WLKDGQLI 1775
Query: 383 PMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQ 442
+ L+G + ++ A+ + GL C A A T KK + V P
Sbjct: 1776 DERDGFKILLNGRKLVIAQ----AQVSNTGL-YRCMA---ANTAGDHKKEFEVTVHVPPT 1827
Query: 443 KLWIEGPPEGQKLRAGTR-VRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGS 501
I+ +++ + V L C+A G P PS+ W KD + V ++ G+
Sbjct: 1828 ---IKSSGLSERVVVKYKPVALQCIA-NGIPNPSITWLKDDQPVNTAQ----------GN 1873
Query: 502 VEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPT--------NVT 549
++ S R L + ++ ++TC AG+ QL V PP+ N T
Sbjct: 1874 LKIQSS--GRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNET 1931
Query: 550 ILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL 609
+L + + + L C + + PV ++W K+ L G + + R +
Sbjct: 1932 VLVS-------NPVQLECKAAGNPVPV-ITWYKDNRLLSGSTSM--------TFLNRGQI 1975
Query: 610 LQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVS 669
+ + S + + FY L V P G +V V L
Sbjct: 1976 IDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNN-PVRLECE 2034
Query: 670 VSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAE 729
PAP + W G +S + L L + +D G Y N+ G +
Sbjct: 2035 ARGIPAP-SLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQ 2093
Query: 730 ARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGED---EEDQS 786
+ L V+ P I + V + +V+++C DA P P W + G + S
Sbjct: 2094 RDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIP--PPTLTWLKDGHPLLKKPGLS 2151
Query: 787 LDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPL 846
+ + + L+I A++ G Y C N VA + + + P + L
Sbjct: 2152 ISENRSV-------LKIEDAQVQDTGRYTCEATN-VAGKTEKNYNVNIWVPPNIGGSDEL 2203
Query: 847 TKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTI 906
T++ + S L C + G+P W K G P+ L D G ++I
Sbjct: 2204 TQLTVIEGNLIS--LLCESSGIPPPNLIWKKKGSPV-LTDSMGRVRILSGG--RQLQISI 2258
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
A S D AL++C A+N G+ + L RP
Sbjct: 2259 AEKS---DAALYSCVASNVAGTAKKEYNLQVYIRP 2290
Score = 120 bits (300), Expect = 1e-26
Identities = 211/912 (23%), Positives = 333/912 (36%), Gaps = 107/912 (11%)
Query: 38 PENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
P ++TV+ V L C + P + W ++G R+ PR R+ G +L
Sbjct: 3628 PRDITVLRNRQVTLECKSDAVPPPVITWLRNG------ERLQATPRVRI----LSGGRYL 3677
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTM-VTWVAGQE 155
I DL D A Y C V + G + IL++ VPP + + G + + +
Sbjct: 3678 QINNADLGDTANYTC-VASNIAGK--TTREFILTVNVPPNI-----KGGPQSLVILLNKS 3729
Query: 156 YVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLL 215
V+ C++ + P P IT G ++ A + L A T R
Sbjct: 3730 TVLECIA-EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGR-------Y 3781
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLAT 275
+C A++ A + V+V PP I PG V L C A G P +
Sbjct: 3782 LCMATNAAGTDRRRIDLQVHV-----PPSIA-PGPTNMTVIVNVQTTLACEATG-IPKPS 3834
Query: 276 LQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQ 335
+ W KNG ++ + ++ LV+ D A C N AG + + L
Sbjct: 3835 INWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNG--AGDDKRTVDLT 3892
Query: 336 VTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGG 395
V PPS T++ ++C + S P + W +LLP DG
Sbjct: 3893 VQVPPSIADEPTDFLVTKHAPAVITCTA-SGVPFPSIHWTKNGIRLLPRG----DGYR-- 3945
Query: 396 HISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKL 455
+S + LA + ++ TC A + A + + + L+V P I+ P +
Sbjct: 3946 ILSSGAIEILATQLNHAGRYTCVARNAAGSAH---RHVTLHVHEPPV---IQPQPSELHV 3999
Query: 456 RAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVL 515
+ L C A G P P + W K+ V S R H +V SG L +
Sbjct: 4000 ILNNPILLPCEATG-TPSPFITWQKEGINVNTSG------RNH--AVLPSGG-----LQI 4045
Query: 516 VTGPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
++ + C AG +L VQ PP ++ + + L+C
Sbjct: 4046 SRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIAVDKPITLSC-EAD 4103
Query: 572 SNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELR 631
PP +++W K+G + R S + + +Q H TC A A +
Sbjct: 4104 GLPPPDITWHKDGRAI----VESIRQRVLSSGSLQIAFVQPGDAGH---YTCMA--ANVA 4154
Query: 632 ETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPA 691
+ S+ +L V P + T E +A+LP P P A NW L+
Sbjct: 4155 GSSSTSTKLTVHVPPRIRSTEGHY-TVNENSQAILPCVADGIPTP-AINWKKDNVLLANL 4212
Query: 692 GGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEV 751
G ++ G L L NV D G Y N+ G + L VH PT L +
Sbjct: 4213 LG-KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSL 4271
Query: 752 NVGGSVDIVCTVDANPI--LPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
N G + + C P+ L FN ++ S L I
Sbjct: 4272 NKGEQLRLSCKATGIPLPKLTWTFN----------NNIIPAHFDSVNGHSELVIERVSKE 4321
Query: 810 QAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVP 869
+G Y C +N V + + + V+ P + P + G +A L+C +G P
Sbjct: 4322 DSGTYVCTAENSVGF-VKAIGFVYVKEPPVFKGDYPSNWIEPLG---GNAILNCEVKGDP 4377
Query: 870 NIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSD 929
W + GV +++ H Q G + SL V+ +D +TC ATN G
Sbjct: 4378 TPTIQWNRKGVDIEI------SHRIRQLG-NGSLAIYGTVN--EDAGDYTCVATNEAGVV 4428
Query: 930 QTNIQLVSISRP 941
+ ++ L S P
Sbjct: 4429 ERSMSLTLQSPP 4440
Score = 117 bits (293), Expect = 7e-26
Identities = 215/956 (22%), Positives = 370/956 (38%), Gaps = 136/956 (14%)
Query: 3 LGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRC---GVSTPG 59
LG T + + + + + + +VP P++L ++ S L C GV TP
Sbjct: 3684 LGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP- 3742
Query: 60 SAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMG 119
+ W KDG +L + RY + + LHI++ ++D Y C + + G
Sbjct: 3743 -RITWRKDGAVLAGN-----HARYSILENG-----FLHIQSAHVTDTGRYLC-MATNAAG 3790
Query: 120 PELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQT 179
+ R+ L + VPP + T +T + + + C P P I +G
Sbjct: 3791 TD--RRRIDLQVHVPPSIA----PGPTNMTVIVNVQTTLAC-EATGIPKPSINWRKNGHL 3843
Query: 180 ISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFP 239
+ NV++ + + S D+ C ++ A + TV V
Sbjct: 3844 L-----NVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV--- 3895
Query: 240 PGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVAR 299
PP I D + ++ + C A G P ++ W KNG + + + ++
Sbjct: 3896 --PPSIADEPTDFLVTKHAPAV-ITCTA-SGVPFPSIHWTKNG--IRLLPRGDGYRILSS 3949
Query: 300 SVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTE---NKN 356
+ + +H + +C A N+ AG+ +TL V PP +I S+ N
Sbjct: 3950 GAIEILATQLNHAGRYTCVARNA--AGSAHRHVTLHVHEPP---VIQPQPSELHVILNNP 4004
Query: 357 VTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDG--LHGGHISMSNLTFLARREDNGLT 414
+ L C + + P + W ++ + + + + L G + +S A RED G T
Sbjct: 4005 ILLPCEATGT-PSPFITWQ---KEGINVNTSGRNHAVLPSGGLQISR----AVREDAG-T 4055
Query: 415 LTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEP 474
C A + A T + LNV+ P I + + + L C A G P P
Sbjct: 4056 YMCVAQNPAGTA---LGKIKLNVQVPPV---ISPHLKEYVIAVDKPITLSCEA-DGLPPP 4108
Query: 475 SLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA---- 530
+ W+KD R + ES R + GS++ + P D +TC A
Sbjct: 4109 DITWHKDGRAIVESI---RQRVLSSGSLQ----------IAFVQPGD-AGHYTCMAANVA 4154
Query: 531 GQLSASTQLAVQFPPT------NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEG 584
G S ST+L V PP + T+ N+ A+ P CV+ P ++W K+
Sbjct: 4155 GSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILP-------CVADGIPTPA-INWKKDN 4206
Query: 585 ERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLY 644
L + P+ G +V+L+ S TC A++A +T + ++VL
Sbjct: 4207 VLLANLLGKYTAEPY-GELILENVVLEDSGF-----YTCVANNAAGEDTHTVSLTVHVL- 4259
Query: 645 RPEFLGEQVLVVTAVEQGEAL-LPVSVSANPAPEAFNWTFRGYRLSPAGGPRH--RILSS 701
P F ++ ++ +GE L L + P P+ WTF + P H +
Sbjct: 4260 -PTFT--ELPGDVSLNKGEQLRLSCKATGIPLPK-LTWTFNNNII-----PAHFDSVNGH 4310
Query: 702 GALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVN-VGGSVDIV 760
L + V++ D G Y +NS G +A + V P + + +GG+ +
Sbjct: 4311 SELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILN 4370
Query: 761 CTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDN 820
C V +P W R G D ++ +I + G L I+ AG Y C+ N
Sbjct: 4371 CEVKGDPT--PTIQWNRKGVD-----IEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATN 4423
Query: 821 GVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGV 880
A R + L ++ P + T + A G L+C+A G P TW++ G
Sbjct: 4424 E-AGVVERSMSLTLQSPPIITLEPVETVINAGG----KIILNCQATGEPQPTITWSRQGH 4478
Query: 881 PLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLV 936
+ D + ++ L IA+ + +D + F C A N +GS + ++
Sbjct: 4479 SISWDD--------RVNVLSNNSLYIAD-AQKEDTSEFECVARNLMGSVLVRVPVI 4525
Score = 112 bits (279), Expect = 3e-24
Identities = 207/913 (22%), Positives = 340/913 (37%), Gaps = 137/913 (15%)
Query: 39 ENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLH 97
E ++V+ +EL C S P + W KDG L ++ GE L
Sbjct: 3536 EEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTL---------GGGEV-LR 3585
Query: 98 IEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTM----VTWVAG 153
I + D Y C + S G + ++ + VPP + AGT +T +
Sbjct: 3586 ISTAQVEDTGRYTC-LASSPAGDD--DKEYLVRVHVPPNI------AGTDEPRDITVLRN 3636
Query: 154 QEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQ 213
++ + C S DA P P IT L +G+ + + ++ + ++ +
Sbjct: 3637 RQVTLECKS-DAVPPPVITWLRNGERLQATP-------RVRILSGGRYLQINNADLGDTA 3688
Query: 214 LLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
C AS+ A + + TVNV PP I+ G + +S L C+A G P
Sbjct: 3689 NYTCVASNIAGKTTREFILTVNV-----PPNIKG-GPQSLVILLNKSTVLECIAEGV-PT 3741
Query: 274 ATLQWLKNGQPVSTAWGTEHTQAVARS--VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHG 331
+ W K+G ++ G ++ + + + + D G L C A N+ AGT
Sbjct: 3742 PRITWRKDGAVLA---GNHARYSILENGFLHIQSAHVTDTGRYL-CMATNA--AGTDRRR 3795
Query: 332 ITLQVTFPPSAIIILGSASQTENKNV--TLSCVSKSSRPRVLLRWWLGWRQLLPMEETVM 389
I LQV PPS I G + T NV TL+C + + P+ + W L +
Sbjct: 3796 IDLQVHVPPS--IAPGPTNMTVIVNVQTTLACEA-TGIPKPSINWRKNGHLLNVDQNQNS 3852
Query: 390 DGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP 449
L +S +L ++ D+ T C + A K+++ L V+ P I
Sbjct: 3853 YRL----LSSGSLVIISPSVDDTATYECTVTNGAGDD---KRTVDLTVQVPPS---IADE 3902
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQES--RRVHLGSVEKSGS 507
P + + C A G P PS+ W K+ + LP+ R + G++E
Sbjct: 3903 PTDFLVTKHAPAVITCTA-SGVPFPSIHWTKNGIRL----LPRGDGYRILSSGAIE---- 3953
Query: 508 TFSRELVLVTGPSDNQAKFTCKAGQLSASTQL----------AVQFPPTNVTILANASAL 557
++ ++ ++TC A + S +Q P+ + ++ N L
Sbjct: 3954 -------ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPIL 4006
Query: 558 RPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDH 617
P +A + P ++W KEG + P G +R+V R+
Sbjct: 4007 LPCEA--------TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAV------RED 4052
Query: 618 GQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANP--- 674
C A + T +LNV P V AV++ P+++S
Sbjct: 4053 AGTYMCVAQNPA--GTALGKIKLNVQVPPVISPHLKEYVIAVDK-----PITLSCEADGL 4105
Query: 675 APEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRL 734
P W G + + R R+LSSG+L + V D G Y N G++ +L
Sbjct: 4106 PPPDITWHKDGRAIVES--IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKL 4163
Query: 735 DVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKIS 794
VH P IR+ + VN + C D P NW++ + + + K +
Sbjct: 4164 TVHVPPRIRSTEGHYTVNENSQAILPCVADGIP--TPAINWKK----DNVLLANLLGKYT 4217
Query: 795 RGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGD 854
P G L + + L +G Y C+ +N + V E P ++ +
Sbjct: 4218 AEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSL-----N 4272
Query: 855 STSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQD 914
L C+A G+P TWT N + H S L I VS +D
Sbjct: 4273 KGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH---------SELVIERVS-KED 4322
Query: 915 YALFTCTATNALG 927
+ CTA N++G
Sbjct: 4323 SGTYVCTAENSVG 4335
Score = 110 bits (276), Expect = 6e-24
Identities = 215/911 (23%), Positives = 337/911 (36%), Gaps = 121/911 (13%)
Query: 49 VELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDA 107
+EL C V+ +P + W KDG L+ D R GF + L G L I +S+
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLI--DER-DGF-KILLNGRK------LVIAQAQVSNTG 1801
Query: 108 EYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKP 167
Y C + + +++ VPP + +V + + + C++ P
Sbjct: 1802 LYRCMAANTAGDHK---KEFEVTVHVPPTIKSSGLSERVVVKY---KPVALQCIANGI-P 1854
Query: 168 APDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAP 227
P IT L Q ++ N+ S ++ + T ++ C A++ A E
Sbjct: 1855 NPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLL------EDAGRYTCVATNAAGETQ 1908
Query: 228 IKASFTVNVLFPPGPPVIEWPG--LDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPV 285
V+ PP +E G L+E V ++L C A GNP+ + W K+ + +
Sbjct: 1909 QHIQLHVHE-----PPSLEDAGKMLNET-VLVSNPVQLECKA-AGNPVPVITWYKDNRLL 1961
Query: 286 STAWGTEHTQAVARSVLVMTVRPEDHGAQL-SCEAHNSVSAGTQEHGITLQVTFPPSAII 344
S G+ + R ++ + A + C A NS AG E +LQV PS
Sbjct: 1962 S---GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINS--AGATELFYSLQVHVAPSISG 2016
Query: 345 ILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTF 404
+ N V L C ++ L WL + + L GG I
Sbjct: 2017 SNNMVAVVVNNPVRLECEARGIPAPSLT--WLKDGSPVSSFSNGLQVLSGGRILALTS-- 2072
Query: 405 LARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLV 464
A+ D G TC A + A K+ + + L V P I G + + V L+
Sbjct: 2073 -AQISDTG-RYTCVAVNAAGEKQ---RDIDLRVYVPPN---IMGEEQNVSVLISQAVELL 2124
Query: 465 CLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRE---LVLVTGPSD 521
C + P P+L W KD + ++K G + S L +
Sbjct: 2125 CQS-DAIPPPTLTWLKDGHPL----------------LKKPGLSISENRSVLKIEDAQVQ 2167
Query: 522 NQAKFTCKAGQLSASTQ----LAVQFPP--------TNVTILANASALRPGDALNLTCVS 569
+ ++TC+A ++ T+ + + PP T +T++ G+ ++L C S
Sbjct: 2168 DTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIE-------GNLISLLCES 2220
Query: 570 VSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAE 629
S PP NL W K+G + + + R + + ++ + +C A +
Sbjct: 2221 -SGIPPPNLIWKKKGSPV----LTDSMGRVRILSGGRQLQISIAEKSDAALYSCVA--SN 2273
Query: 630 LRETVSSFYRLNVLYRPEFL--GEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYR 687
+ T Y L V RP G + L V P P W G+
Sbjct: 2274 VAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTV-TWMKDGHP 2332
Query: 688 LSPAGGPRHRILSSG-ALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRAL- 745
L A G IL G L L N+ +D G Y N G + + L VH P+I
Sbjct: 2333 LIKAKGVE--ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNH 2390
Query: 746 QDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGR-LRIH 804
+ P ++V + T +A+ I W + D SL + +I G GR LR+
Sbjct: 2391 RSPENISVVEKNSVSLTCEASGIPLPSITWFK---DGWPVSLSNSVRILSG--GRMLRLM 2445
Query: 805 HAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCR 864
+ AG Y C+V N A R++ L V P + L V S TL C
Sbjct: 2446 QTTMEDAGQYTCVVRNA-AGEERKIFGLSVLVPPHIVGENTLEDVKVK--EKQSVTLTCE 2502
Query: 865 ARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATN 924
G P TW K+G PL + H GG L I NV +TC A++
Sbjct: 2503 VTGNPVPEITWHKDGQPLQEDE----AHHIISGG---RFLQITNVQVPHT-GRYTCLASS 2554
Query: 925 ALGSDQTNIQL 935
G + L
Sbjct: 2555 PAGHKSRSFSL 2565
Score = 85.5 bits (210), Expect = 3e-16
Identities = 165/753 (21%), Positives = 282/753 (37%), Gaps = 89/753 (11%)
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLAT 275
+CEA + I++ TV V P + P + +V GQ L LPC GNP+
Sbjct: 866 ICEAENQF--GKIQSETTVTVTGLVAPLIGISPSV--ANVIEGQQLTLPCTLLAGNPIPE 921
Query: 276 LQWLKNGQPVSTAWGTEHTQAVARS---VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGI 332
+W+KN +A ++ RS + + V+ +D G + +C A N AGT
Sbjct: 922 RRWIKN-----SAMLLQNPYITVRSDGSLHIERVQLQD-GGEYTCVASNV--AGTNNKTT 973
Query: 333 TLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGL 392
++ V P+ S E VTL C + S P+ + W + G
Sbjct: 974 SVVVHVLPTIQHGQQILSTIEGIPVTLPCKA-SGNPKPSVIWSKKGELISTSSAKFSAGA 1032
Query: 393 HGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVK-YPAQKLWIEGPPE 451
G +S E++G + + + K + ++ + + + Q+ + P
Sbjct: 1033 DGSLYVVS-----PGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPV 1087
Query: 452 GQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSR 511
+ AG V L C + P P + W K+++ ++ P R L SGS
Sbjct: 1088 EISVLAGEEVTLPC-EVKSLPPPIITWAKETQLIS----PFSPRHTFL----PSGSMKIT 1138
Query: 512 ELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQFPPTNVTILANASALRPGDALNLTC 567
E T SD+ + C A G ++ + +L V PP + ++ G +++ C
Sbjct: 1139 E----TRTSDS-GMYLCVATNIAGNVTQAVKLNVHVPP-KIQRGPKHLKVQVGQRVDIPC 1192
Query: 568 VSVSSNPPVNLSWDKEGERL-----------EGVAAPPRRAPFKGSAAARSVLLQVSSRD 616
+ + PV ++W K G + +G + + P + V ++ D
Sbjct: 1193 NAQGTPLPV-ITWSKGGSTMLVDGEHHVSNPDGTLSIDQATP-SDAGIYTCVATNIAGTD 1250
Query: 617 HGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAP 676
+ +T E + Y N ++ +++ P P P
Sbjct: 1251 ETE-ITLHVQEPPTVEDLEPPY--NTTFQERVANQRIE-----------FPCPAKGTPKP 1296
Query: 677 EAFNWTFRGYRLSPAGGPRHRILSSGALH-LWNVTRADDGLYQLHCQNSEGTAEARLRLD 735
W G L+ P IL G L + +VT D+G Y N GT E + L
Sbjct: 1297 -TIKWLHNGRELT-GREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLK 1354
Query: 736 VHYAPTIRALQDPTEVNV--GGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKI 793
VH P I+ + T V+V ++ C V+ P + W + + S ++ +
Sbjct: 1355 VHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP--SPIIMWYKDNVQVTESST--IQTV 1410
Query: 794 SRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAG 853
+ G L++ A AG Y C N +A +++ + V P + +V+
Sbjct: 1411 NNGKI--LKLFRATPEDAGRYSCKAIN-IAGTSQKYFNIDVLVPPTIIGTNFPNEVSVV- 1466
Query: 854 DSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQ 913
L C+ +G P W K+G PL L DP +G V L + N +
Sbjct: 1467 -LNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNV--ELLDRGQV----LHLKN-ARRN 1518
Query: 914 DYALFTCTATNALGSDQTNIQLVSISRPDPPSG 946
D + CT +NA G +I+L P G
Sbjct: 1519 DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Score = 79.3 bits (194), Expect = 2e-14
Identities = 155/716 (21%), Positives = 253/716 (35%), Gaps = 85/716 (11%)
Query: 240 PGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVAR 299
P P + P G+ Q ++PC P TL +++NG + + + +V
Sbjct: 428 PDAPKVTMPEKTPGYYL--QPGQIPCSVDSLLPF-TLSFVRNGVTLGVDQYLKESASVNL 484
Query: 300 SVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTL 359
+ +T+ E C A +S AGT V+ PP I + + + T + L
Sbjct: 485 DIAKVTLSDEGF---YECIAVSS--AGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVL 539
Query: 360 SCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEA 419
+C+ S+ L W R + E + L + + ++ F E + C
Sbjct: 540 TCLIISAVD-YNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYH-----CMV 593
Query: 420 FSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWY 479
SE + S+ L V+ P + + P+ Q G+ V ++C A G P+P + W
Sbjct: 594 SSEGGSSAA---SVFLTVQEPPK---VTVMPKNQSFTGGSEVSIMCSATG-YPKPKIAWT 646
Query: 480 KDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSA---- 535
+ + S H + G+ F + P D + C A +
Sbjct: 647 VNDMFIVGS---------HRYRMTSDGTLFIKN----AAPKD-AGIYGCLASNSAGTDKQ 692
Query: 536 -STQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPP 594
ST ++ P + ++ + + GD + C S PP + W K L P
Sbjct: 693 NSTLRYIEAP--KLMVVQSELLVALGDITVMEC-KTSGIPPPQVKWFKGDLELR-----P 744
Query: 595 RRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVL 654
+ + D G TC A + R T L+V P F+ E
Sbjct: 745 STFLIIDPLLGLLKIQETQDLDAGD-YTCVAINEAGRATGK--ITLDVGSPPVFIQEPAD 801
Query: 655 VVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLS-------PAGGPRHRILSSGALHLW 707
V + LP V P P T + RL P L +GAL +
Sbjct: 802 VSMEIGSN-VTLPCYVQGYPEP-----TIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855
Query: 708 NVTRADDGLYQLHCQNSEGTAEARLRLDVH--YAPTIRALQDPTEVNVGGSVDIVCTVDA 765
N+ +D G Y +N G ++ + V AP I V G + + CT+ A
Sbjct: 856 NLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLA 915
Query: 766 NPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPP 825
+P W + L I+ G L I +L G Y C+ N VA
Sbjct: 916 GNPIPER-RWIK-----NSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASN-VAGT 968
Query: 826 ARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQ 885
+ +VV P ++H + TL C+A G P W+K G +
Sbjct: 969 NNKTTSVVVHVLPTIQHGQQILSTIEG----IPVTLPCKASGNPKPSVIWSKKGELISTS 1024
Query: 886 DPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
+++ G SL ++ ++ + CTATN G + +QL RP
Sbjct: 1025 SAKFS------AGADGSLYVVS--PGGEESGEYVCTATNTAGYAKRKVQLTVYVRP 1072
Score = 65.1 bits (157), Expect = 4e-10
Identities = 117/547 (21%), Positives = 204/547 (37%), Gaps = 52/547 (9%)
Query: 413 LTLTCEAFSEAFTKE---TFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIG 469
+TL+ E F E T + +V P + + P + G R L CL I
Sbjct: 489 VTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQV---PNNVTVTPGERAVLTCLIIS 545
Query: 470 GNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCK 529
+ +L W ++ R V RL + +R L ++ + + V + + +
Sbjct: 546 A-VDYNLTWQRNDRDV---RLAEPARIRTLANL-----SLELKSVKFNDAGEYHCMVSSE 596
Query: 530 AGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEG 589
G +AS L VQ PP VT++ + G +++ C S + P ++W + G
Sbjct: 597 GGSSAASVFLTVQEPP-KVTVMPKNQSFTGGSEVSIMC-SATGYPKPKIAWTVNDMFIVG 654
Query: 590 VAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFL 649
++ ++ + + +D G ++SA + S+ L + P+ +
Sbjct: 655 SHR------YRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNST---LRYIEAPKLM 705
Query: 650 GEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSS--GALHLW 707
Q ++ A+ G+ + ++ P W L P+ I+ G L +
Sbjct: 706 VVQSELLVAL--GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQ 760
Query: 708 NVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVN--VGGSVDIVCTVDA 765
D G Y N G A ++ LDV P +Q+P +V+ +G +V + C V
Sbjct: 761 ETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVF--IQEPADVSMEIGSNVTLPCYVQG 818
Query: 766 NPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAP- 824
P W RL + IS+ TG L I + + G Y C +N
Sbjct: 819 YP--EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKI 876
Query: 825 PARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDL 884
+ + + AP + + V T TL G P W KN L L
Sbjct: 877 QSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTL---LAGNPIPERRWIKNSAML-L 932
Query: 885 QDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPP 944
Q+P T + G +H + + QD +TC A+N G++ +V P
Sbjct: 933 QNPYITVRS--DGSLHIERVQL------QDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 945 SGLKVVS 951
G +++S
Sbjct: 985 HGQQILS 991
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 126 bits (317), Expect = 1e-28
Identities = 194/818 (23%), Positives = 311/818 (38%), Gaps = 75/818 (9%)
Query: 249 GLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPV--STAWGTEHTQAVARSVLVMTV 306
G V AG ++ELPC A G P+ ++WLK+G+P+ + W T + + +
Sbjct: 291 GFHSQEVWAGHTVELPCTA-SGYPIPAIRWLKDGRPLPADSRWTKRIT-----GLTISDL 344
Query: 307 RPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSS 366
R ED G + CE N+ G+ E L V P + V LSC S
Sbjct: 345 RTEDSGTYI-CEVTNTF--GSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGS 401
Query: 367 RPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTK 426
P +RW+ +LP E + GL S L + ++ + C A +A T
Sbjct: 402 -PEFTIRWYRNTELVLPDEAISIRGL-----SNETLLITSAQKSHSGAYQCFATRKAQTA 455
Query: 427 ETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVT 486
+ F I+ ++ + I + + G + L+C A G P P++ W D +
Sbjct: 456 QDFA---IIALEDGTPR--IVSSFSEKVVNPGEQFSLMCAAKGA-PPPTVTWALDDEPIV 509
Query: 487 ESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAK-FTCKAGQLSASTQLAVQFP- 544
S R + ++ G+T S + VTGP + C A L S + +
Sbjct: 510 RDG----SHRTNQYTMS-DGTTISH--MNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
Query: 545 --PTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGS 602
P ++ + N +A+ D L + C V P ++ W K+ L R+ F+
Sbjct: 563 RGPPSIRAMRNITAVAGRDTL-INC-RVIGYPYYSIKWYKDALLLPD---NHRQVVFENG 617
Query: 603 AAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQG 662
+ + + D G+ + +L + S + V P + Q G
Sbjct: 618 TLKLTDVQK--GMDEGEYLCSVLIQPQLSISQSVHVAVKV---PPLI--QPFEFPPASIG 670
Query: 663 EAL-LPVSVSANPAPEAFNWTFRGYRLSPAGG---PRHRILSSGALHLWNVTRADDGLYQ 718
+ L +P VS+ P W G + G +SS L + +V+ +G Y
Sbjct: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS--LQISSVSLKHNGNYT 728
Query: 719 LHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIV-CTVDANPILPGMFNWER 777
N+ T +L V P +Q + + G ++ C+VD P P W+
Sbjct: 729 CIASNAAATVSRERQLIVRVPPRF-VVQPNNQDGIYGKAGVLNCSVDGYP--PPKVMWKH 785
Query: 778 L---GEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVV 834
G ++ + +I P L I H G Y C NGV + + L V
Sbjct: 786 AKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
Query: 835 RFAPQV-EHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDP-RYTEH 892
+ + HP T +A G + L+C ARG I+ W K +D RY
Sbjct: 846 KIPAMITSHPN--TTIAIKGHAKE---LNCTARGERPIIIRWEKGDTVIDPDRVMRYAIA 900
Query: 893 TYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSL 952
T G S L + D F+C A N+ G D+ IQL PDPP L++ +
Sbjct: 901 TKDNGDEVVSTLKLKPADRG-DSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE-LEIREV 958
Query: 953 TPHSVGLEWKPGFDG-GLPQRFCIRYEALGTPGFHYVDV--VPPQATTFTLTGLQPSTRY 1009
S+ L W FDG + F I Y+ + P + L P++ Y
Sbjct: 959 KARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVY 1018
Query: 1010 RVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPED 1047
+ + + N +G S + +L I+T P G P D
Sbjct: 1019 SIRMYSFNKIGRS---EPSKELTISTEEA-APDGPPMD 1052
Score = 59.3 bits (142), Expect = 2e-08
Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 16/171 (9%)
Query: 861 LHCRARGVPNIVFTWTKNG----VPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
L C + G P WTK+ +P+ + R +H++ + A+D
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRL---------IHTNGTLLLRAVKAEDSG 1419
Query: 917 LFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQR-FCI 975
+TCTATN G D + L+ PD P L V + S+ L W PG +GG R F +
Sbjct: 1420 YYTCTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVL 1478
Query: 976 RYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLAD 1026
+Y + + V + +F L L+ T Y+V L A N++G +++
Sbjct: 1479 QYSVDNSEEWKDV-FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISE 1528
Score = 58.5 bits (140), Expect = 4e-08
Identities = 129/542 (23%), Positives = 196/542 (36%), Gaps = 64/542 (11%)
Query: 19 EGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRI 77
+ A +A+ PR + E + V G L C P V WA D P R
Sbjct: 456 QDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMCAAKGAPPPTVTWALDD---EPIVRD 511
Query: 78 PGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKL 137
+ H+++ + D Y C R+ +G R+ ++ PP +
Sbjct: 512 GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRC-TARNLVGSAEYQARI--NVRGPPSI 568
Query: 138 LLLTPEAGTMVTWVAGQEYVVNC-VSGDAKPAPDITILLSGQTISDISANVN-EGSQQKL 195
A +T VAG++ ++NC V G P I + D V E KL
Sbjct: 569 -----RAMRNITAVAGRDTLINCRVIG--YPYYSIKWYKDALLLPDNHRQVVFENGTLKL 621
Query: 196 FTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHV 255
V+ + D + L P L I S V V PP E+P
Sbjct: 622 TDVQ-------KGMDEGEYLCSVLIQPQLS--ISQSVHVAVKVPPLIQPFEFPPAS---- 668
Query: 256 RAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQL 315
GQ L +PCV G+ + W K+GQ + + G S L ++ H
Sbjct: 669 -IGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNY 727
Query: 316 SCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSC-VSKSSRPRVLLRW 374
+C A N+ + ++E + ++V PP ++ + K L+C V P+V+ +
Sbjct: 728 TCIASNAAATVSRERQLIVRV--PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKH 785
Query: 375 WLGW---RQLLPMEETVMDGLHGGHIS-MSNLTFLAR---REDNGLTLTCEAFSEAFTKE 427
G +Q P+ T G I + N + L R ED G L C+A + T
Sbjct: 786 AKGSGNPQQYHPVPLT-------GRIQILPNSSLLIRHVLEEDIGYYL-CQASNGVGT-- 835
Query: 428 TFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE 487
KS+ L VK PA I P G L C A G P + W K +
Sbjct: 836 DISKSMFLTVKIPAM---ITSHPNTTIAIKGHAKELNCTARGERP-IIIRWEKGDTVIDP 891
Query: 488 SRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQF 543
R+ + + + + +G L L + F+C A G+ QL VQ
Sbjct: 892 DRVMR-----YAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQE 946
Query: 544 PP 545
PP
Sbjct: 947 PP 948
Score = 55.5 bits (132), Expect = 3e-07
Identities = 121/548 (22%), Positives = 202/548 (36%), Gaps = 77/548 (14%)
Query: 46 GASVELRCGVST-PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLS 104
G +VEL C S P A++W KDG L D R R+ G L I
Sbjct: 300 GHTVELPCTASGYPIPAIRWLKDGRPLPADSRW----TKRITG--------LTISDLRTE 347
Query: 105 DDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGD 164
D Y C+V + E + +++ P + LTP+ + T + G +++C
Sbjct: 348 DSGTYICEVTNTFGSAEATG----ILMVIDPLHVTLTPK--KLKTGI-GSTVILSCA--- 397
Query: 165 AKPAPDITILLSGQT---ISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASS 221
+P+ TI T + D + ++ S + L +T + C A+
Sbjct: 398 LTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-------ITSAQKSHSGAYQCFATR 450
Query: 222 PALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKN 281
A A F + L P ++ E V G+ L C A+G P T+ W +
Sbjct: 451 KAQTA---QDFAIIALEDGTPRIVS--SFSEKVVNPGEQFSLMCAAKGAPP-PTVTWALD 504
Query: 282 GQPV---STAWGTEHTQAVARSVLVMTVRPED--HGAQLSCEAHNSVSAGTQEHGITLQV 336
+P+ + ++T + ++ M V G C A N V G+ E+ + V
Sbjct: 505 DEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV--GSAEYQARINV 562
Query: 337 TFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGH 396
PPS I + + + ++ ++C P ++W+ LLP + +G
Sbjct: 563 RGPPS-IRAMRNITAVAGRDTLINC-RVIGYPYYSIKWYKD-ALLLPDNHRQVVFENG-- 617
Query: 397 ISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLR 456
LT + + D G L C + + + +S+ + VK P E PP
Sbjct: 618 --TLKLTDVQKGMDEGEYL-CSVLIQ--PQLSISQSVHVAVKVPPLIQPFEFPPAS---- 668
Query: 457 AGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLV 516
G + + C+ G+ + W KD + + V F L +
Sbjct: 669 IGQLLYIPCVVSSGDMPIRITWRKDGQVIISG-----------SGVTIESKEFMSSLQIS 717
Query: 517 TGPSDNQAKFTCKAGQLSAST----QLAVQFPPTNVTILANASALRPGDALNLTCVSVSS 572
+ + +TC A +A+ QL V+ PP V N + G A L C SV
Sbjct: 718 SVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY-GKAGVLNC-SVDG 775
Query: 573 NPPVNLSW 580
PP + W
Sbjct: 776 YPPPKVMW 783
Score = 50.4 bits (119), Expect = 1e-05
Identities = 115/523 (21%), Positives = 194/523 (37%), Gaps = 53/523 (10%)
Query: 263 LPCVARGGNPLATLQW-LKNGQPVSTAWGTEHTQAVARSVLV----MTVRPEDHGAQLSC 317
+PC A G+P A L+W L G + H A L H C
Sbjct: 105 VPCPA-AGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFC 163
Query: 318 EAHNSVSAGTQEHGITLQVTF-PPSAIIILGSASQTENKNVTLSCVSKSSRPRV-LLRWW 375
A N+ + I ++ F P + + S N V + S + V ++ W
Sbjct: 164 TAENAAGK-IRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWE 222
Query: 376 LGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLIL 435
++P E HGG + +S++ ++ED T C + + L
Sbjct: 223 KDTVSIIP-EHRFFITYHGG-LYISDV----QKEDALSTYRCITKHKYSGETRQSNGARL 276
Query: 436 NVKYPAQKL-WIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQES 494
+V PA+ + I Q++ AG V L C A G P P++ W KD R LP +S
Sbjct: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTA-SGYPIPAIRWLKDGRP-----LPADS 330
Query: 495 RRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSAS---TQLAVQFPPTNVTIL 551
R + +G T S +++ + C+ S T + + P +VT+
Sbjct: 331 R----WTKRITGLTISDLR------TEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT 380
Query: 552 ANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQ 611
G + L+C +++ +P + W + E + P +G + ++L+
Sbjct: 381 PKKLKTGIGSTVILSC-ALTGSPEFTIRWYRNTE----LVLPDEAISIRG-LSNETLLIT 434
Query: 612 VSSRDHGQRVTCRAHSAELRETVSSFYRLNVLY-RPEFLGEQVLVVTAVEQGEALLPVSV 670
+ + H C A +T F + + P + V GE +
Sbjct: 435 SAQKSHSGAYQCFA--TRKAQTAQDFAIIALEDGTPRIVSS--FSEKVVNPGEQFSLMCA 490
Query: 671 SANPAPEAFNWTFRGYRLSPAGGPRHR--ILSSGA-LHLWNVTRA---DDGLYQLHCQNS 724
+ P W + G R +S G + NVT D G+Y+ +N
Sbjct: 491 AKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNL 550
Query: 725 EGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANP 767
G+AE + R++V P+IRA+++ T V G I C V P
Sbjct: 551 VGSAEYQARINVRGPPSIRAMRNITAV-AGRDTLINCRVIGYP 592
Score = 31.6 bits (70), Expect = 4.9
Identities = 24/95 (25%), Positives = 43/95 (45%), Gaps = 4/95 (4%)
Query: 941 PDPPSGLKVVSLTPHSVGLEW-KPGFDGGLPQRFCIRYEALGT--PGFHYVDVVPPQATT 997
P PP+G+K V + SV + W P G+ +++ I + G+ P + P Q
Sbjct: 1251 PGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQ-LF 1309
Query: 998 FTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLP 1032
+ + L +Y +W+ A + G ++K T P
Sbjct: 1310 YRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEP 1344
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 126 bits (316), Expect = 1e-28
Identities = 172/650 (26%), Positives = 249/650 (38%), Gaps = 83/650 (12%)
Query: 446 IEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKS 505
+E PP+ R G L C A G P P++ WYK+ V R + R+ L S
Sbjct: 67 VEQPPDLLVSR-GEPATLPCRA-EGRPRPNIEWYKNGARVATVREDPRAHRLLL----PS 120
Query: 506 GSTFSRELVLVTGPSDNQAKFTC-------KAGQLSASTQLAV-----QFPPTNVTILAN 553
G+ F +V ++ +TC A +AS ++AV + P NV +
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
Query: 554 ASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVS 613
A+ L CV +P ++SW K+G RL+ R +G S L+
Sbjct: 181 EPAV-------LECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLK-- 228
Query: 614 SRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSAN 673
D G V ++ A RE+ ++ + VL RP FL V V + L V +
Sbjct: 229 -SDAGMYVCVASNMAGERESAAA--EVMVLERPSFLRRPVNQVVLADAPVTFL-CEVKGD 284
Query: 674 PAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLR 733
P P W L P G R+ I S +L + +V+ D+G Y +NS G AEA
Sbjct: 285 PPPR-LRWRKEDGEL-PTG--RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGS 340
Query: 734 LDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDE---EDQSLDDM 790
L VH P + G SV C NP P W++ G QSL
Sbjct: 341 LSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNP--PPAIFWQKEGSQVLLFPSQSLQPT 398
Query: 791 EKISRGPTGRLRIHHAKLAQAGAYQC----IVDNGVAPPARRLLRLVVRFAPQVEHPTPL 846
+ S P G+L I + AG Y C + + +A + + P V P
Sbjct: 399 GRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPA 458
Query: 847 TKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTI 906
+ G SS L CR G P W K+G L D ++ + + L I
Sbjct: 459 NQTLVLG---SSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKT-------MANGTLYI 508
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQL--------------VSISRPDPPSGLKVVSL 952
ANV D ++C A ++ G + L S P PS V +
Sbjct: 509 ANVQ-EMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEI 567
Query: 953 TPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVP-PQATTFTLTGLQPSTRYRV 1011
T +S+ L WKP G + G + V Q T T++GLQP+T +
Sbjct: 568 TKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNT---I 624
Query: 1012 WLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPP-SGPSGL 1060
+L A+G GL++ P++ P Q S P E P G GL
Sbjct: 625 YLFLVRAVGAWGLSEPS---PVSEPVRTQDSSPSR---PVEDPWRGQQGL 668
Score = 53.1 bits (126), Expect = 2e-06
Identities = 128/549 (23%), Positives = 198/549 (36%), Gaps = 89/549 (16%)
Query: 116 SEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILL 175
S +GPE PR++ PP LL+ E T+ G +P P+I
Sbjct: 55 SRVGPEDAMPRIVEQ---PPDLLVSRGEPATLPCRAEG------------RPRPNIEWYK 99
Query: 176 SGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQ------LLVCEASSP-ALEAPI 228
+G + A V E + + + A PR R+ + C A + A
Sbjct: 100 NGARV----ATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR 155
Query: 229 KASFTVNVL---FPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPV 285
AS V VL F P + V G+ L CV G+P ++ W K+G +
Sbjct: 156 NASLEVAVLRDDFRQSPGNVV--------VAVGEPAVLECVPPRGHPEPSVSWRKDGARL 207
Query: 286 STAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT-LQVTFPPSAII 344
E + L+M+ + C A N AG +E + V PS +
Sbjct: 208 KE---EEGRITIRGGKLMMSHTLKSDAGMYVCVASN--MAGERESAAAEVMVLERPSFLR 262
Query: 345 ILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMD--GLHGGHISMSNL 402
+ + VT C K P LRW +L + L GH+S
Sbjct: 263 RPVNQVVLADAPVTFLCEVKGD-PPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVS---- 317
Query: 403 TFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVR 462
ED G T TC A + E S L+V P Q + P+ Q G V
Sbjct: 318 -----AEDEG-TYTCVAENSVGRAEA---SGSLSVHVPPQ---LVTQPQDQMAAPGESVA 365
Query: 463 LVCLAIGGNPEPSLMWYKDSRTV----TESRLP------QESRRVHLGSVEK-SGSTFSR 511
C GNP P++ W K+ V ++S P ++++ +V++ +
Sbjct: 366 FQC-ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC 424
Query: 512 ELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
+ V V G +A K L + +Q P +L G ++ L C V+
Sbjct: 425 QAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL--------GSSVWLPC-RVT 475
Query: 572 SNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELR 631
NP ++ W K+G+ L+G FK A + V D G +C A S+
Sbjct: 476 GNPQPSVRWKKDGQWLQG-----DDLQFKTMANGTLYIANVQEMDMG-FYSCVAKSSTGE 529
Query: 632 ETVSSFYRL 640
T S + ++
Sbjct: 530 ATWSGWLKM 538
Score = 32.3 bits (72), Expect = 2.9
Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 6/71 (8%)
Query: 6 TLRASLLLLGLLT-EGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQ 63
++ S+L LL +G + +P + +G P N T+V G+SV L C V+ P +V+
Sbjct: 428 SVAGSILAKALLEIKGASLDGLPPVILQG----PANQTLVLGSSVWLPCRVTGNPQPSVR 483
Query: 64 WAKDGLLLGPD 74
W KDG L D
Sbjct: 484 WKKDGQWLQGD 494
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 125 bits (315), Expect = 2e-28
Identities = 106/344 (30%), Positives = 151/344 (43%), Gaps = 33/344 (9%)
Query: 34 FWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGE 93
F PE+L V+ G L C + VQW K GL LG +PG+ RY + G+ A G+
Sbjct: 26 FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
Query: 94 FHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAG 153
LHI +L D+A YECQ ++ L S L +LVPP+ + G V+ VAG
Sbjct: 86 HDLHIRPVELEDEASYECQATQA----GLRSRPAQLHVLVPPEAPQVL--GGPSVSLVAG 139
Query: 154 QEYVVNCVS-GDAKPAPDIT-----ILLSGQTISDISANVNEGSQQKLFTVEATARVTPR 207
+ C S GDA+P P++ +LL G T + EG+ +VE+T +TP
Sbjct: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFH--QTLLKEGTPG---SVESTLTLTPF 194
Query: 208 SSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVA 267
S D+ VC A S AL + T+++ +PP + P V+ G+ + C A
Sbjct: 195 SHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT----VQEGEKVIFLCQA 250
Query: 268 RGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGT 327
P+ +W K G PV A G S L V SCE N+V G+
Sbjct: 251 TAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV---------SCEVSNAV--GS 299
Query: 328 QEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSS-RPRV 370
L V F P S ++ + SC + + PRV
Sbjct: 300 ANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRV 343
Score = 82.0 bits (201), Expect = 3e-15
Identities = 110/430 (25%), Positives = 172/430 (40%), Gaps = 56/430 (13%)
Query: 521 DNQAKFTCKAGQL---SASTQLAVQFPPTNVTILANAS-ALRPGDALNLTCVSVS-SNPP 575
+++A + C+A Q S QL V PP +L S +L G NLTC S + P
Sbjct: 96 EDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPT 155
Query: 576 VNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL-LQVSSRDHGQRVTCRAHSAELRETV 634
L W ++G L+G + S L L S D G CRA S L
Sbjct: 156 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 215
Query: 635 SSFYRLNVLYRPEFLGEQVLVVTA----VEQGEALLPV-SVSANPAPEAFNWTFRGYRLS 689
+ L++ Y PE + ++A V++GE ++ + +A P + W G +
Sbjct: 216 DTAITLSLQYPPE------VTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL 269
Query: 690 PAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPT 749
A GPR +++ + V+ N+ G+A LDV + P ++A +P
Sbjct: 270 GARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 321
Query: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
V+VG C NP LP + W R G + + G T LR+
Sbjct: 322 SVDVGEDASFSCAWRGNP-LPRV-TWTRRG---------GAQVLGSGAT--LRLPSVGPE 368
Query: 810 QAGAYQCIVDNGVA--PPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARG 867
AG Y C + G++ RL V P V T L +A A L C
Sbjct: 369 DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV---TALH--SAPAFLRGPARLQCLVFA 423
Query: 868 VP---NIVFTWTKNGVPLDLQDPRYTEHTY----HQGGVHSSLLTIANVSAAQDYAL--- 917
P +V++W + + Q R+ T+ +GG+ L+++ ++S Q+
Sbjct: 424 SPAPDAVVWSWDEGFLEAGSQG-RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
Query: 918 FTCTATNALG 927
F C+A N LG
Sbjct: 483 FNCSARNRLG 492
Score = 60.5 bits (145), Expect = 1e-08
Identities = 98/396 (24%), Positives = 151/396 (38%), Gaps = 66/396 (16%)
Query: 204 VTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-GPPVIEWPGLDEGHVRAGQSLE 262
+ P ++ C+A+ L + ++VL PP P V+ P + + AG
Sbjct: 90 IRPVELEDEASYECQATQAGLRS---RPAQLHVLVPPEAPQVLGGPSVS---LVAGVPAN 143
Query: 263 LPCVARG-GNPLATLQWLKNGQPVSTAWG-----TEHTQAVARSVLVMTVRPEDHGAQLS 316
L C +RG P L W ++G + A E T S L +T D GA
Sbjct: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
Query: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376
C A + ++ ITL + +PP + + E + V C + + P RW
Sbjct: 204 CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
Query: 377 GWRQLLPMEETVMDGLHGGHIS-MSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLIL 435
G +L G G + +++ +FL ++CE + + +S L
Sbjct: 264 GGSPVL--------GARGPRLEVVADASFLTE------PVSCEVSNAV---GSANRSTAL 306
Query: 436 NVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESR 495
+V + ++ PE + G C A GNP P + W +R
Sbjct: 307 DVLFGP---ILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTW---------------TR 347
Query: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA-GQLS------ASTQLAVQFPPTNV 548
R G + GS + L V GP D + C+A LS A +L V PP V
Sbjct: 348 R---GGAQVLGSGATLRLPSV-GPED-AGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-V 401
Query: 549 TILANASALRPGDALNLTCVSVSSNPP--VNLSWDK 582
T L +A A G A L C+ +S P V SWD+
Sbjct: 402 TALHSAPAFLRGPA-RLQCLVFASPAPDAVVWSWDE 436
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 125 bits (315), Expect = 2e-28
Identities = 106/344 (30%), Positives = 151/344 (43%), Gaps = 33/344 (9%)
Query: 34 FWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGE 93
F PE+L V+ G L C + VQW K GL LG +PG+ RY + G+ A G+
Sbjct: 26 FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
Query: 94 FHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAG 153
LHI +L D+A YECQ ++ L S L +LVPP+ + G V+ VAG
Sbjct: 86 HDLHIRPVELEDEASYECQATQA----GLRSRPAQLHVLVPPEAPQVL--GGPSVSLVAG 139
Query: 154 QEYVVNCVS-GDAKPAPDIT-----ILLSGQTISDISANVNEGSQQKLFTVEATARVTPR 207
+ C S GDA+P P++ +LL G T + EG+ +VE+T +TP
Sbjct: 140 VPANLTCRSRGDARPTPELLWFRDGVLLDGATFH--QTLLKEGTPG---SVESTLTLTPF 194
Query: 208 SSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVA 267
S D+ VC A S AL + T+++ +PP + P V+ G+ + C A
Sbjct: 195 SHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT----VQEGEKVIFLCQA 250
Query: 268 RGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGT 327
P+ +W K G PV A G S L V SCE N+V G+
Sbjct: 251 TAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV---------SCEVSNAV--GS 299
Query: 328 QEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSS-RPRV 370
L V F P S ++ + SC + + PRV
Sbjct: 300 ANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRV 343
Score = 82.0 bits (201), Expect = 3e-15
Identities = 110/430 (25%), Positives = 172/430 (40%), Gaps = 56/430 (13%)
Query: 521 DNQAKFTCKAGQL---SASTQLAVQFPPTNVTILANAS-ALRPGDALNLTCVSVS-SNPP 575
+++A + C+A Q S QL V PP +L S +L G NLTC S + P
Sbjct: 96 EDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPT 155
Query: 576 VNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL-LQVSSRDHGQRVTCRAHSAELRETV 634
L W ++G L+G + S L L S D G CRA S L
Sbjct: 156 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 215
Query: 635 SSFYRLNVLYRPEFLGEQVLVVTA----VEQGEALLPV-SVSANPAPEAFNWTFRGYRLS 689
+ L++ Y PE + ++A V++GE ++ + +A P + W G +
Sbjct: 216 DTAITLSLQYPPE------VTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL 269
Query: 690 PAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPT 749
A GPR +++ + V+ N+ G+A LDV + P ++A +P
Sbjct: 270 GARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 321
Query: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
V+VG C NP LP + W R G + + G T LR+
Sbjct: 322 SVDVGEDASFSCAWRGNP-LPRV-TWTRRG---------GAQVLGSGAT--LRLPSVGPE 368
Query: 810 QAGAYQCIVDNGVA--PPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARG 867
AG Y C + G++ RL V P V T L +A A L C
Sbjct: 369 DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV---TALH--SAPAFLRGPARLQCLVFA 423
Query: 868 VP---NIVFTWTKNGVPLDLQDPRYTEHTY----HQGGVHSSLLTIANVSAAQDYAL--- 917
P +V++W + + Q R+ T+ +GG+ L+++ ++S Q+
Sbjct: 424 SPAPDAVVWSWDEGFLEAGSQG-RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 482
Query: 918 FTCTATNALG 927
F C+A N LG
Sbjct: 483 FNCSARNRLG 492
Score = 60.5 bits (145), Expect = 1e-08
Identities = 98/396 (24%), Positives = 151/396 (38%), Gaps = 66/396 (16%)
Query: 204 VTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-GPPVIEWPGLDEGHVRAGQSLE 262
+ P ++ C+A+ L + ++VL PP P V+ P + + AG
Sbjct: 90 IRPVELEDEASYECQATQAGLRS---RPAQLHVLVPPEAPQVLGGPSVS---LVAGVPAN 143
Query: 263 LPCVARG-GNPLATLQWLKNGQPVSTAWG-----TEHTQAVARSVLVMTVRPEDHGAQLS 316
L C +RG P L W ++G + A E T S L +T D GA
Sbjct: 144 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 203
Query: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376
C A + ++ ITL + +PP + + E + V C + + P RW
Sbjct: 204 CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 263
Query: 377 GWRQLLPMEETVMDGLHGGHIS-MSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLIL 435
G +L G G + +++ +FL ++CE + + +S L
Sbjct: 264 GGSPVL--------GARGPRLEVVADASFLTE------PVSCEVSNAV---GSANRSTAL 306
Query: 436 NVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESR 495
+V + ++ PE + G C A GNP P + W +R
Sbjct: 307 DVLFGP---ILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTW---------------TR 347
Query: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA-GQLS------ASTQLAVQFPPTNV 548
R G + GS + L V GP D + C+A LS A +L V PP V
Sbjct: 348 R---GGAQVLGSGATLRLPSV-GPED-AGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-V 401
Query: 549 TILANASALRPGDALNLTCVSVSSNPP--VNLSWDK 582
T L +A A G A L C+ +S P V SWD+
Sbjct: 402 TALHSAPAFLRGPA-RLQCLVFASPAPDAVVWSWDE 436
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 123 bits (309), Expect = 1e-27
Identities = 184/838 (21%), Positives = 321/838 (38%), Gaps = 95/838 (11%)
Query: 249 GLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRP 308
G D AGQ +ELPC A G +P +WLK+ P+ + + T +L+ +RP
Sbjct: 230 GFDHRKAMAGQRVELPCKALG-HPEPDYRWLKDNMPLELSGRFQKT---VTGLLIENIRP 285
Query: 309 EDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRP 368
D G+ + CE N GT + L V P A I + V+LSC +
Sbjct: 286 SDSGSYV-CEVSNRY--GTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTED 342
Query: 369 RVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKET 428
+ L W+ L P + + G++ ++ M ++ + D G +
Sbjct: 343 QEL-SWYRNGEILNPGKNVRITGINHENLIMDHMV----KSDGG------------AYQC 385
Query: 429 FKKSLILNVKYPAQKLWIEGPPE------GQKLRAGTRVRLVCLAIGGNPEPSLMWYKDS 482
F + L+ + Q + +G P+ + + V L+C + G P P++ W D
Sbjct: 386 FVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMC-NVKGTPLPTITWTLDD 444
Query: 483 RTVTESRLPQESRRV----HLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQ 538
+ + + S+ + ++ S S+ R+ + ++N A +++
Sbjct: 445 DPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGP 504
Query: 539 LAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAP 598
+++ P N+T +A G + C V P ++ W K L P
Sbjct: 505 ASIR-PMKNITAIA-------GRDTYIHC-RVIGYPYYSIKWYKNSNLL----------P 545
Query: 599 FKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTA 658
F QV+ ++G T + + +E Y NVL +P+ Q + VT
Sbjct: 546 FNHR--------QVAFENNG---TLKLSDVQ-KEVDEGEYTCNVLVQPQLSTSQSVHVTV 593
Query: 659 -----VEQGE---------ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPR-HRILSSGA 703
++ E +P V + P W G + + G I + +
Sbjct: 594 KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS 653
Query: 704 LHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTV 763
L + N++ +G Y +N E + +L V P + G +V + C+
Sbjct: 654 LRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSA 713
Query: 764 DANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVA 823
+ P+ ++ + + + Q + +I G L I H +G Y C V N V
Sbjct: 714 EGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG 773
Query: 824 PPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLD 883
+ + L V+ P + P T +A G + C A G I+ W K ++
Sbjct: 774 ADVSKSMYLTVKI-PAMITSYPNTTLATQGQKKE---MSCTAHGEKPIIVRWEKEDRIIN 829
Query: 884 LQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDP 943
+ RY T G S L I + +D F+C A N+ G D+ IQL PDP
Sbjct: 830 PEMARYLVSTKEVGEEVISTLQILP-TVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDP 888
Query: 944 PSGLKVVSLTPHSVGLEWKPGFDGGLP---QRFCIRYEALGTPGFHYVDVVPPQATTFTL 1000
P +++ + ++ L W GFDG P + ++ V PQ + T+
Sbjct: 889 PE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATI 947
Query: 1001 TGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPS 1058
+ PS+ Y + + A N +G S + +L IT P G P+ ++ EP S S
Sbjct: 948 IDIHPSSTYSIRMYAKNRIGKS---EPSNELTITADEA-APDGPPQ-EVHLEPISSQS 1000
Score = 66.2 bits (160), Expect = 2e-10
Identities = 124/547 (22%), Positives = 200/547 (36%), Gaps = 69/547 (12%)
Query: 16 LLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPD 74
L + Q+ + P+ A E + V V L C V TP + W D D
Sbjct: 392 LSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLDD-----D 445
Query: 75 PRIPGFPRYRLEGDPARGEF--HLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSIL 132
P + G + + G +L+I + + D Y C S G L R+ ++
Sbjct: 446 PILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSA-GVVLYQARI--NVR 502
Query: 133 VPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEG-- 190
P + + +T +AG++ ++C + G I N
Sbjct: 503 GPASIRPMKN-----ITAIAGRDTYIHC-------------RVIGYPYYSIKWYKNSNLL 544
Query: 191 ---SQQKLFTVEATARVTP--RSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVI 245
+Q F T +++ + D + P L TV V PP
Sbjct: 545 PFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV--PPFIQPF 602
Query: 246 EWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMT 305
E+P GQ + +PCV G+ T+ W K+G+P+ + G S L ++
Sbjct: 603 EFPRFS-----IGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRIS 657
Query: 306 VRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKS 365
H +C A N +A EH L V PP ++ K V L+C S
Sbjct: 658 NLSLMHNGNYTCIARNEAAA--VEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNC-SAE 714
Query: 366 SRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLAR---REDNGLTLTCEAFSE 422
P + W +P + + L+G +SN + L + ED+G L C+ ++
Sbjct: 715 GYPVPTIVWKFSKGAGVPQFQPI--ALNGRIQVLSNGSLLIKHVVEEDSGYYL-CKVSND 771
Query: 423 AFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDS 482
KS+ L VK PA I P G + + C A G P + W K+
Sbjct: 772 --VGADVSKSMYLTVKIPAM---ITSYPNTTLATQGQKKEMSCTAHGEKP-IIVRWEKED 825
Query: 483 RTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQ 538
R + P+ +R +L S ++ G L ++ ++ F+C A G+ Q
Sbjct: 826 RIIN----PEMAR--YLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQ 879
Query: 539 LAVQFPP 545
L VQ PP
Sbjct: 880 LTVQEPP 886
Score = 52.8 bits (125), Expect = 2e-06
Identities = 48/170 (28%), Positives = 75/170 (44%), Gaps = 14/170 (8%)
Query: 861 LHCRARGVPNIVFTWTK--NGVP-LDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYAL 917
L C+A G P+ W K NG P L D R + + S+ I A+D
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS--------IFSNGSFIIRTVKAEDSGY 1356
Query: 918 FTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQR-FCIR 976
++C A N GSD+ + L PD P L V T S+ L W PG +GG R + ++
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSSIRGYILQ 1415
Query: 977 YEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLAD 1026
Y + + + P + ++ L L+ T Y+ L A N +G +++
Sbjct: 1416 YSEDNSEQWGSFPISPSE-RSYRLENLKCGTWYKFTLTAQNGVGPGRISE 1464
Score = 51.6 bits (122), Expect = 5e-06
Identities = 160/843 (18%), Positives = 300/843 (35%), Gaps = 110/843 (13%)
Query: 228 IKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVST 287
+ A V V+ G P I E V + + L C +G PL T+ W + P+
Sbjct: 392 LSAQDYVQVVLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKG-TPLPTITWTLDDDPILK 449
Query: 288 AWGTEHTQAVAR-----SVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSA 342
+Q + S L ++ G C A+NS + I ++ P++
Sbjct: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR---GPAS 506
Query: 343 IIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNL 402
I + + + ++ + C P ++W+ LLP + + G + +S++
Sbjct: 507 IRPMKNITAIAGRDTYIHC-RVIGYPYYSIKWYKN-SNLLPFNHRQVAFENNGTLKLSDV 564
Query: 403 TFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVR 462
+ D G TC + + + +S+ + VK P +I+ P E + G RV
Sbjct: 565 Q---KEVDEG-EYTCNVLVQP--QLSTSQSVHVTVKVPP---FIQ-PFEFPRFSIGQRVF 614
Query: 463 LVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDN 522
+ C+ + G+ ++ W KD R + S V + +++ + S L L+ +
Sbjct: 615 IPCVVVSGDLPITITWQKDGRPIPGSL------GVTIDNIDFTSSLRISNLSLM-----H 663
Query: 523 QAKFTC----KAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNL 578
+TC +A + +QL V+ PP V + + G A+ L C S P +
Sbjct: 664 NGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIY-GKAVILNC-SAEGYPVPTI 721
Query: 579 SWDKEGERLEGVAAPPRRAPFKGSAAAR-----SVLLQVSSRDHGQRVTCRAHSAELRET 633
W + A P+ P + + S+L++ + C+ + +
Sbjct: 722 VW-----KFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADV 776
Query: 634 VSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGG 693
S Y + + + T QG+ + P W ++P
Sbjct: 777 SKSMY---LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMA 833
Query: 694 PRHRILSS-------GALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQ 746
R+ + + L + R D G + H NS G ++L V P
Sbjct: 834 -RYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP------ 886
Query: 747 DPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHA 806
DP E+ + T+ G N G D E ++ D S R +
Sbjct: 887 DPPEIEIKDVKARTITLRWTMGFDG--NSPITGYDIECKNKSD----SWDSAQRTKDVSP 940
Query: 807 KLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAA--AGDSTSSATLHCR 864
+L A I+D + P + +R+ + P+ + A A +H
Sbjct: 941 QLNSA----TIID--IHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLE 994
Query: 865 ARGVPNIVFTWT------KNGVPLDLQDPRYTEHTYHQGGVH------------SSLLTI 906
+I TW +NG+ ++ + Y GG S + T+
Sbjct: 995 PISSQSIRVTWKAPKKHLQNGI---IRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTL 1051
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPD----PPSGLKVVSLTPHSVGLEW- 961
N++ Y L A N G+ ++ ++++ + D PP ++ ++ +P S+ + W
Sbjct: 1052 DNLNKFTQYGLVV-QACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWS 1110
Query: 962 ---KPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNA 1018
K +G L I + L + + + L GL+ T Y + +LA
Sbjct: 1111 TLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTR 1170
Query: 1019 LGD 1021
GD
Sbjct: 1171 AGD 1173
Score = 32.7 bits (73), Expect = 2.2
Identities = 35/130 (26%), Positives = 57/130 (43%), Gaps = 26/130 (20%)
Query: 463 LVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDN 522
L C A+G +P P++ W KDS T S + + RR S+ +GS ++ T +++
Sbjct: 1305 LPCKAVG-DPSPAVKWMKDSNG-TPSLVTIDGRR----SIFSNGS-----FIIRTVKAED 1353
Query: 523 QAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSW-- 580
++C A S + I+ N P D LT VS +++ + LSW
Sbjct: 1354 SGYYSCIANNNWGSDE-----------IILNLQVQVPPDQPRLT-VSKTTSSSITLSWLP 1401
Query: 581 -DKEGERLEG 589
D G + G
Sbjct: 1402 GDNGGSSIRG 1411
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 123 bits (308), Expect = 1e-27
Identities = 227/928 (24%), Positives = 342/928 (36%), Gaps = 150/928 (16%)
Query: 38 PENLTVVEGASVELRCGVSTPGSA---VQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEF 94
P + V EG +++L+C V PG A V W K G L PAR +
Sbjct: 2833 PSSSRVAEGQTLDLKCVV--PGQAHAQVTWHKRGGNL-----------------PARHQV 2873
Query: 95 H---LHIEACDLSDDAEYECQVGRSEMGPEL-----VSPRVILSILVPPKLLLLTPEAGT 146
H L + +D EY CQV S E + P I P + EA +
Sbjct: 2874 HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASS 2933
Query: 147 MVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTP 206
GQ +NCV A +T G ++ + + GSQ +L V
Sbjct: 2934 SHV-TEGQTLDLNCVVPGQAHA-QVTWYKRGGSLP--ARHQTHGSQLRLHLVSP------ 2983
Query: 207 RSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGP--------PVIEWPGLDEGHVRAG 258
+D+ + + AS P E +ASFTV V PP PVI V+ G
Sbjct: 2984 --ADSGEYVCRAASGPGPEQ--EASFTVTV--PPSEGSSYRLRSPVISIDP-PSSTVQQG 3036
Query: 259 QSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCE 318
Q C+ G +L+W Q + H + ++ RP +HG C
Sbjct: 3037 QDASFKCLIHDGAAPISLEWKTRNQELED---NVHISPNGSIITIVGTRPSNHGTY-RCV 3092
Query: 319 AHNSVSAGTQEHGITLQVTFPPSAIIIL-GSASQTENKNVTLSCVSKSSRPRVLLRWWLG 377
A N+ G + + L V PP+ ++ G K VTL CVS + PR RW
Sbjct: 3093 ASNAY--GVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVS-AGEPRSSARWTRI 3149
Query: 378 WRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNV 437
+E+ GL H + + A+ D G T C A + T + + ++
Sbjct: 3150 SSTPAKLEQRTY-GLMDSHAVLQISS--AKPSDAG-TYVCLAQNALGTAQKQVEVIVDTG 3205
Query: 438 KYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRV 497
++ + AG L C A G +P P++ W K S LP + R
Sbjct: 3206 AMAPGAPQVQAEEAELTVEAGHTATLRCSATG-SPAPTIHWSK-----LRSPLPWQHRL- 3258
Query: 498 HLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASAL 557
G T V T AG A+ L V+ PP T+ +AS +
Sbjct: 3259 -------EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHAS-V 3310
Query: 558 RPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLL---QVSS 614
+ G+ + L C++ PP+ W + G L G A AR+ LL + +
Sbjct: 3311 QAGETVQLQCLA-HGTPPLTFQWSRVGSSLPG------------RATARNELLHFERAAP 3357
Query: 615 RDHGQ---RVTCRAHSAELRETVSSFYRLNVLYRPEFL-------GEQVLVVTAVEQGEA 664
D G+ RVT + SAE +F +L V P L G V +
Sbjct: 3358 EDSGRYRCRVTNKVGSAE------AFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETK 3411
Query: 665 LLPVSVSANPA-PEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQN 723
+ SV + A P R ++ P H + G L + N+ ++ G Y
Sbjct: 3412 SIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV-QDGVLRIQNLDQSCQGTYICQAHG 3470
Query: 724 SEGTAEARLRLDVHYAPT--IRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGED 781
G A+A +L + P+ I V VG +V+ C +P W ++G
Sbjct: 3471 PWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDP--KPQVTWSKVGGH 3528
Query: 782 EEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVE 841
+ G +RI H +LA AG Y+C N +L L+V+ PQ+
Sbjct: 3529 LRPGIVQS--------GGVVRIAHVELADAGQYRCTATNAAGTTQSHVL-LLVQALPQIS 3579
Query: 842 HPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTK--NGVPLDLQDPRYTEHTYHQGGV 899
P + A S+A C A G P +W+K +P D + +
Sbjct: 3580 MPQEVRVPAG-----SAAVFPCIASGYPTPDISWSKLDGSLPPDSR-------------L 3621
Query: 900 HSSLLTIANVSAAQDYALFTCTATNALG 927
+++L + +V QD + CTATN G
Sbjct: 3622 ENNMLMLPSVRP-QDAGTYVCTATNRQG 3648
Score = 94.0 bits (232), Expect = 8e-19
Identities = 219/957 (22%), Positives = 348/957 (36%), Gaps = 166/957 (17%)
Query: 42 TVVEGASVELRCGVST-PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEA 100
TVVEG +++L C V+ P + + W K G G P R++ G HL +
Sbjct: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRG---GSLPS-----RHQTHGS------HLRLHQ 2685
Query: 101 CDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNC 160
++D EY C R+ + + +++S+ +P AG+ G +
Sbjct: 2686 MSVADSGEYVC---RANNNIDALEASIVISV---------SPSAGSPSA--PGSSMPIRI 2731
Query: 161 VSGDAKPAP----DITILLSGQTISDISANVNEGSQQKLFTVEATA----RVTPRSSDNR 212
S + A D+ ++ GQ + ++ + GS + V+P S
Sbjct: 2732 ESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEY 2791
Query: 213 QLLVCEASSPALEAPI------KASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCV 266
V +S P LEA + S V+V P G P I V GQ+L+L CV
Sbjct: 2792 VCRVMGSSGP-LEASVLVTIEASGSSAVHVPAPGGAPPIRIEP-SSSRVAEGQTLDLKCV 2849
Query: 267 ARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAG 326
G A + W K G + Q + + V P D G + SC+ S +G
Sbjct: 2850 VPG-QAHAQVTWHKRGGNLPA-----RHQVHGPLLRLNQVSPADSG-EYSCQVTGS--SG 2900
Query: 327 TQEHGITLQVTFPPSA------------IIILGSASQ-TENKNVTLSCVSKSSRPRVLLR 373
T E + VT PS+ I I S+S TE + + L+CV + +
Sbjct: 2901 TLEASVL--VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPG-QAHAQVT 2957
Query: 374 WWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSL 433
W+ L +T HG + + L D+G C A S ++ ++
Sbjct: 2958 WYKRGGSLPARHQT-----HGSQLRLH----LVSPADSG-EYVCRAASGPGPEQEASFTV 3007
Query: 434 IL----NVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR 489
+ Y + I P ++ G CL G SL W ++R
Sbjct: 3008 TVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEW--------KTR 3059
Query: 490 LPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQFPP 545
+ VH + +GS + ++ T PS N + C A G + L+V PP
Sbjct: 3060 NQELEDNVH---ISPNGSIIT---IVGTRPS-NHGTYRCVASNAYGVAQSVVNLSVHGPP 3112
Query: 546 TNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAA 605
T + ++ G A+ L CVS + P + W + +++ P + +
Sbjct: 3113 TVSVLPEGPVWVKVGKAVTLECVS-AGEPRSSARWTR-------ISSTPAKLEQRTYGLM 3164
Query: 606 RS-VLLQVSSRDHGQRVT--CRAHSA--ELRETVSSFYRLNVLY--RPEFLGEQVLVVTA 658
S +LQ+SS T C A +A ++ V + P+ E+ +
Sbjct: 3165 DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELT-- 3222
Query: 659 VEQGE-ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLY 717
VE G A L S + +PAP +W+ +L +HR L L + V + D G Y
Sbjct: 3223 VEAGHTATLRCSATGSPAP-TIHWS----KLRSPLPWQHR-LEGDTLIIPRVAQQDSGQY 3276
Query: 718 QLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWER 777
+ + G AEA + L V P + + V G +V + C P P F W R
Sbjct: 3277 ICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTP--PLTFQWSR 3334
Query: 778 LGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFA 837
+G ++ E L A +G Y+C V N V A +L+V+
Sbjct: 3335 VGSSLPGRATARNE--------LLHFERAAPEDSGRYRCRVTNKVG-SAEAFAQLLVQGP 3385
Query: 838 PQVEHPTPLTKVAAAGDST-------------SSATLHCRARGVPNIVFTWTKNGVPLDL 884
P P T + A T +S HC W K G L
Sbjct: 3386 P---GSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQL-- 3440
Query: 885 QDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
P ++ V +L I N+ + + C A G Q + QLV + P
Sbjct: 3441 -PPGHS--------VQDGVLRIQNLDQSCQ-GTYICQAHGPWGKAQASAQLVIQALP 3487
Score = 90.9 bits (224), Expect = 7e-18
Identities = 217/946 (22%), Positives = 334/946 (35%), Gaps = 147/946 (15%)
Query: 38 PENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFH- 95
P LTV G E RC + +P ++W GP ++P A+ + H
Sbjct: 1872 PPQLTVQPGQLAEFRCSATGSPTPTLEWTG-----GPGGQLP-----------AKAQIHG 1915
Query: 96 --LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAG 153
L + A + +D A+Y C+ S G ++ R +L + + T V AG
Sbjct: 1916 GILRLPAVEPTDQAQYLCRA-HSSAGQQVA--RAVLHVHGGGGPRVQVSPERTQVH--AG 1970
Query: 154 QEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQ 213
+ + C + P+ IT G ++ + + T AT + ++ +
Sbjct: 1971 RTVRLYCRAAGV-PSATITWRKEGGSLPPQARSER--------TDIATLLIPAITTADAG 2021
Query: 214 LLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
+C A+SPA A + V PP ++ V GQ+L+L CV G+
Sbjct: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPS-VTEGQTLDLNCVV-AGSAH 2079
Query: 274 ATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
A + W + G + HTQ + + V P D G + C N +G +E IT
Sbjct: 2080 AQVTWYRRGGSLPP-----HTQVHGSRLRLPQVSPADSGEYV-CRVENG--SGPKEASIT 2131
Query: 334 LQVTFP----PSAIIILGSASQ----------TENKNVTLSCVSKSSRPRVLLRWWLGWR 379
+ V PS + GS E + + L+CV + + W
Sbjct: 2132 VSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPG-QAHAQVTWHKRGG 2190
Query: 380 QLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKY 439
L +T HG + + +T E + EA T + S+I
Sbjct: 2191 SLPARHQT-----HGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPG--- 2242
Query: 440 PAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRR--- 496
P + IE + G + L C+ + G + WYK ++ + SR
Sbjct: 2243 PIPPVRIES--SSSTVAEGQTLDLSCV-VAGQAHAQVTWYKRGGSLPARHQVRGSRLYIF 2299
Query: 497 ----VHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILA 552
G S + VT A AG STQ + I
Sbjct: 2300 QASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAG----STQ--------PIRIEP 2347
Query: 553 NASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQV 612
++S + G L+L CV V ++W K G L P R GS L Q
Sbjct: 2348 SSSQVAEGQTLDLNCV-VPGQSHAQVTWHKRGGSL------PVRHQTHGSLLR---LYQA 2397
Query: 613 SSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLV-----VTAVEQGEALLP 667
S D G+ V CR + + S + LG V + V +G+ L
Sbjct: 2398 SPADSGEYV-CRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDL 2456
Query: 668 VSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGT 727
+ A A W RG L PA RH++ S L L VT AD G Y S GT
Sbjct: 2457 NCLVAGQAHAQVTWHKRGGSL-PA---RHQVHGS-RLRLLQVTPADSGEYVCRVVGSSGT 2511
Query: 728 AEARLRLDVH----------YAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWER 777
EA + + + A +R + G ++D+ C V + P W +
Sbjct: 2512 QEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQ--APHTITWYK 2569
Query: 778 LGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLV---- 833
G SL +I RLRI A +G Y C V NG L+ +
Sbjct: 2570 RG-----GSLPSRHQI---VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSG 2621
Query: 834 VRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHT 893
P V P + + + L+C P + TW K G L +
Sbjct: 2622 SSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP---------S 2672
Query: 894 YHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSIS 939
HQ H S L + +S A D + C A N + + + +I ++S+S
Sbjct: 2673 RHQ--THGSHLRLHQMSVA-DSGEYVCRANNNIDALEASI-VISVS 2714
Score = 89.4 bits (220), Expect = 2e-17
Identities = 220/987 (22%), Positives = 363/987 (36%), Gaps = 159/987 (16%)
Query: 7 LRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSA---VQ 63
+ AS+ + T+G A LA PA + P + V EG +++L C V PG + V
Sbjct: 2317 MEASITVTVTGTQG-ANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVV--PGQSHAQVT 2373
Query: 64 WAKDGLLLGPDPRIPGFPRYRLEGDPARGEFH---LHIEACDLSDDAEYECQVGRSEMGP 120
W K G L P R + H L + +D EY C+V S +
Sbjct: 2374 WHKRGGSL-----------------PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPL 2416
Query: 121 ELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAP----DITILLS 176
E S+LV + P G T V S ++ A D+ L++
Sbjct: 2417 E-------ASVLVTIEPAGSVPALGVTPT--------VRIESSSSQVAEGQTLDLNCLVA 2461
Query: 177 GQTISDISANVNEGSQQKLFTVEAT----ARVTPRSSDNRQLLVCEASSP-------ALE 225
GQ + ++ + GS V + +VTP S V +S ++
Sbjct: 2462 GQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQ 2521
Query: 226 APIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPV 285
+ S + V +P IE + G +L+L C+ P T+ W K G +
Sbjct: 2522 QRLSGSHSQGVAYPVR---IE---SSSASLANGHTLDLNCLVASQAP-HTITWYKRGGSL 2574
Query: 286 STAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQV--------- 336
+ Q V + + V P D G + H S AG++E + + +
Sbjct: 2575 PS-----RHQIVGSRLRIPQVTPADSGEYV---CHVSNGAGSRETSLIVTIQGSGSSHVP 2626
Query: 337 TFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGH 396
+ P I S + E + + L+CV + +P+ ++ W+ L +T HG H
Sbjct: 2627 SVSPPIRIESSSPTVVEGQTLDLNCV-VARQPQAIITWYKRGGSLPSRHQT-----HGSH 2680
Query: 397 ISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNV-------KYPAQKLWIEGP 449
+ + ++ D+G C A + + + S++++V P + I
Sbjct: 2681 LRLHQMSV----ADSG-EYVCRANNNI---DALEASIVISVSPSAGSPSAPGSSMPIRIE 2732
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESR-RVHLGSVEKSGST 508
+ G + L C+ + G + W+K ++ + SR R+H S SG
Sbjct: 2733 SSSSHVAEGETLDLNCV-VPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEY 2791
Query: 509 FSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCV 568
R ++ +GP + T +A SA A P + I ++S + G L+L CV
Sbjct: 2792 VCR-VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP-IRIEPSSSRVAEGQTLDLKCV 2849
Query: 569 SVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSA 628
V ++W K G L P R G + + S ++ +VT + +
Sbjct: 2850 -VPGQAHAQVTWHKRGGNL------PARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTL 2902
Query: 629 ELRETVSSFYRLNVLYRPEFLGEQVLVVTA---VEQGEALLPVSVSANPAPEAFNWTFRG 685
E V+ L + + + + V +G+ L V A W RG
Sbjct: 2903 EASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRG 2962
Query: 686 YRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEG-TAEARLRLDVH------- 737
L PA RH+ S L L V+ AD G Y + G EA + V
Sbjct: 2963 GSL-PA---RHQTHGS-QLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSY 3017
Query: 738 --YAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISR 795
+P I + V G C + + P W+ +Q L+D IS
Sbjct: 3018 RLRSPVISIDPPSSTVQQGQDASFKCLIH-DGAAPISLEWK-----TRNQELEDNVHIS- 3070
Query: 796 GPTGR-LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQV----EHPTPLTKVA 850
P G + I + + G Y+C+ N A+ ++ L V P V E P KV
Sbjct: 3071 -PNGSIITIVGTRPSNHGTYRCVASNAYG-VAQSVVNLSVHGPPTVSVLPEGPV-WVKVG 3127
Query: 851 AAGDSTSSATLHCRARGVPNIVFTWTK-NGVPLDLQDPRYTEHTYHQGGVHSSLLTIANV 909
A TL C + G P WT+ + P L+ Y G + S + +
Sbjct: 3128 KA------VTLECVSAGEPRSSARWTRISSTPAKLEQRTY-------GLMDSHAVLQISS 3174
Query: 910 SAAQDYALFTCTATNALGSDQTNIQLV 936
+ D + C A NALG+ Q ++++
Sbjct: 3175 AKPSDAGTYVCLAQNALGTAQKQVEVI 3201
Score = 84.7 bits (208), Expect = 5e-16
Identities = 218/956 (22%), Positives = 339/956 (35%), Gaps = 174/956 (18%)
Query: 43 VVEGASVELRCGVSTPGSA---VQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIE 99
V EG +++L C V PG A V W K G L + G R RL H+
Sbjct: 2738 VAEGETLDLNCVV--PGQAHAQVTWHKRGGSLPSHHQTRG-SRLRLH----------HVS 2784
Query: 100 ACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVN 159
+D EY C+V S GP S V + + + P + V
Sbjct: 2785 P---ADSGEYVCRVMGSS-GPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
Query: 160 CVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATA----RVTPRSSDNRQLL 215
+ D K ++ GQ + ++ + G+ V +V+P S
Sbjct: 2841 GQTLDLK------CVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQ 2894
Query: 216 VCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDE--------GHVRAGQSLELPCVA 267
V SS LEA + + P P I PGL + HV GQ+L+L CV
Sbjct: 2895 VT-GSSGTLEASVLVTIE-----PSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVV 2948
Query: 268 RGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGT 327
G A + W K G + T +Q + + V P D G + C A S
Sbjct: 2949 PG-QAHAQVTWYKRGGSLPARHQTHGSQ-----LRLHLVSPADSGEYV-CRA---ASGPG 2998
Query: 328 QEHGITLQVTFPPSA---------IIILGSASQT--ENKNVTLSCVSKSSRPRVLLRWWL 376
E + VT PPS +I + S T + ++ + C+ + L W
Sbjct: 2999 PEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKT 3058
Query: 377 GWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILN 436
++L E+ V +G S +T + R N T C A S A+
Sbjct: 3059 RNQEL---EDNVHISPNG-----SIITIVGTRPSNHGTYRCVA-SNAY-----------G 3098
Query: 437 VKYPAQKLWIEGPPEGQKL-------RAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR 489
V L + GPP L + G V L C++ G P S W + S T +
Sbjct: 3099 VAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVS-AGEPRSSARWTRISSTPAKLE 3157
Query: 490 -----LPQESRRVHLGSVEKSGS-TFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQF 543
L + + S + S + T+ G + Q + G ++ VQ
Sbjct: 3158 QRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAP-QVQA 3216
Query: 544 PPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSA 603
+T+ A G L C S + +P + W K L P + +G
Sbjct: 3217 EEAELTVEA-------GHTATLRC-SATGSPAPTIHWSKLRSPL------PWQHRLEGDT 3262
Query: 604 AARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGE 663
++ +V+ +D GQ + C A S + + P + V +V+ GE
Sbjct: 3263 L---IIPRVAQQDSGQYI-CNATSPAGHAEATIILHVE---SPPY-ATTVPEHASVQAGE 3314
Query: 664 ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQN 723
+ ++ P F W+ G L R+ +L H D G Y+ N
Sbjct: 3315 TVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELL-----HFERAAPEDSGRYRCRVTN 3369
Query: 724 SEGTAEARLRLDVH--------------YAPTIRALQDPTEVNVGGSVDIVCTVDANPIL 769
G+AEA +L V PT++ ++G SV+ C V ++
Sbjct: 3370 KVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDR-- 3427
Query: 770 PGMFNW-ERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARR 828
W + G+ S+ D G LRI + + G Y C +G A+
Sbjct: 3428 GTQLRWFKEGGQLPPGHSVQD---------GVLRIQNLDQSCQGTYICQA-HGPWGKAQA 3477
Query: 829 LLRLVVRFAPQVEHPTPLTKVAAAGDST---SSATLHCRARGVPNIVFTWTKNGVPLDLQ 885
+LV++ P V L + + + + C A G P TW+K G L
Sbjct: 3478 SAQLVIQALPSV-----LINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHL--- 3529
Query: 886 DPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
GGV + IA+V A D + CTATNA G+ Q+++ L+ + P
Sbjct: 3530 ----RPGIVQSGGV----VRIAHVELA-DAGQYRCTATNAAGTTQSHVLLLVQALP 3576
Score = 83.2 bits (204), Expect = 1e-15
Identities = 240/1045 (22%), Positives = 373/1045 (35%), Gaps = 166/1045 (15%)
Query: 38 PENLTVVEGASVELRCGVSTPGSA---VQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEF 94
P + V EG +++L C V PG A V W K G L PAR +
Sbjct: 2158 PSSSHVAEGQTLDLNCVV--PGQAHAQVTWHKRGGSL-----------------PARHQT 2198
Query: 95 H---LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWV 151
H L + +D EY C V + GP S V + V P + + T
Sbjct: 2199 HGSLLRLHQVTPADSGEYVCHVVGTS-GPLEASVLVTIEASVIPGPIPPVRIESSSSTVA 2257
Query: 152 AGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATAR-VTPRSSD 210
GQ ++CV ++GQ + ++ GS V + + S
Sbjct: 2258 EGQTLDLSCV-------------VAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPA 2304
Query: 211 NRQLLVCEASSPALEAPIKASFT----VNVLFPPGP--PVIEWPGLDEGHVRAGQSLELP 264
+ VC AS+ +EA I + T N+ +P G P+ P + V GQ+L+L
Sbjct: 2305 DAGQYVCRASN-GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ--VAEGQTLDLN 2361
Query: 265 CVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQL------SCE 318
CV G + A + W K G + T + + + P D G + S
Sbjct: 2362 CVVPGQSH-AQVTWHKRGGSLPVRHQTHGSL-----LRLYQASPADSGEYVCRVLGSSVP 2415
Query: 319 AHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSC-VSKSSRPRVLLRWWLG 377
SV + G + P+ I S+ E + + L+C V+ + +V W
Sbjct: 2416 LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT---WHK 2472
Query: 378 WRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLI--- 434
LP V HG + + +T E + EA T ++ L
Sbjct: 2473 RGGSLPARHQV----HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSH 2528
Query: 435 -LNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQE 493
V YP + IE L G + L CL P ++ WYK ++ SR
Sbjct: 2529 SQGVAYPVR---IES--SSASLANGHTLDLNCLVASQAPH-TITWYKRGGSLP-SRHQIV 2581
Query: 494 SRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILAN 553
R+ + V + S + V+ + ++ Q S S+ + PP + I ++
Sbjct: 2582 GSRLRIPQVTPADS--GEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP--IRIESS 2637
Query: 554 ASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVS 613
+ + G L+L CV V+ P ++W K G L P R GS L Q+S
Sbjct: 2638 SPTVVEGQTLDLNCV-VARQPQAIITWYKRGGSL------PSRHQTHGSHLR---LHQMS 2687
Query: 614 SRDHGQRVTCRAHS-AELRETVSSFYRLNVLYRPEFLGEQVLV-----VTAVEQGEALLP 667
D G+ V CRA++ + E P G + + + V +GE L
Sbjct: 2688 VADSGEYV-CRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDL 2746
Query: 668 VSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGT 727
V A W RG L P H L L +V+ AD G Y S G
Sbjct: 2747 NCVVPGQAHAQVTWHKRGGSL-----PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 728 AEARLRLDVHY-------------APTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFN 774
EA + + + AP IR + V G ++D+ C V
Sbjct: 2802 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQA--HAQVT 2859
Query: 775 WERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVV 834
W + G + L ++ GP LR++ A +G Y C V +L +
Sbjct: 2860 WHKRGGN-----LPARHQV-HGPL--LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE 2911
Query: 835 RFAP-QVEHP---TPLTKVAAAGDSTSSATL--HCRARGVPNIVFTWTKNGVPLDLQDPR 888
+P + P P+ A++ T TL +C G + TW K G L +
Sbjct: 2912 PSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR--- 2968
Query: 889 YTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLK 948
HQ H S L + VS A D + C A + G +Q V++ P S +
Sbjct: 2969 ------HQ--THGSQLRLHLVSPA-DSGEYVCRAASGPGPEQEASFTVTVP-PSEGSSYR 3018
Query: 949 ----VVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDV---------VPPQA 995
V+S+ P S ++ G D C+ ++ + + P
Sbjct: 3019 LRSPVISIDPPSSTVQ--QGQDASFK---CLIHDGAAPISLEWKTRNQELEDNVHISPNG 3073
Query: 996 TTFTLTGLQPSTRYRVWLLASNALG 1020
+ T+ G +PS +ASNA G
Sbjct: 3074 SIITIVGTRPSNHGTYRCVASNAYG 3098
Score = 70.9 bits (172), Expect = 7e-12
Identities = 158/705 (22%), Positives = 248/705 (35%), Gaps = 98/705 (13%)
Query: 255 VRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQ 314
V G S L C G P ++G+PV + H + + +V+P D G
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS---ELHFPSVQPSDAGVY 1744
Query: 315 LSCEAHNSVSAGTQEHGITLQVTFPPSAIIILG-----SASQTENKNVTLSCVSKSSRPR 369
+ C N + T L VT PS I + S S +VT C +KS P
Sbjct: 1745 I-CTCRNLHQSNTSR--AELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPA 1801
Query: 370 VLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETF 429
L W LP +G+ LT + + T C S F +
Sbjct: 1802 YTLVWTRLHNGKLPTRAMDFNGI---------LTIRNVQLSDAGTYVCTG-SNMFAMDQG 1851
Query: 430 KKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR 489
+L + + P ++ G C A G +P P+L W ++
Sbjct: 1852 TATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATG-SPTPTLEWTGGPGGQLPAK 1910
Query: 490 LPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQFPP 545
+ L +VE P+D QA++ C+A GQ A L V
Sbjct: 1911 AQIHGGILRLPAVE---------------PTD-QAQYLCRAHSSAGQQVARAVLHVHGGG 1954
Query: 546 -TNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAA 604
V + + + G + L C + P ++W KEG L P +A + +
Sbjct: 1955 GPRVQVSPERTQVHAGRTVRLYC-RAAGVPSATITWRKEGGSL------PPQARSERTDI 2007
Query: 605 ARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTA---VEQ 661
A ++ +++ D G + A T + ++ VL + V + ++ V +
Sbjct: 2008 ATLLIPAITTADAGFYLCVATSPAG---TAQARIQVVVLSASDASPPPVKIESSSPSVTE 2064
Query: 662 GEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHC 721
G+ L V A A W RG L P H + L L V+ AD G Y
Sbjct: 2065 GQTLDLNCVVAGSAHAQVTWYRRGGSLPP-----HTQVHGSRLRLPQVSPADSGEYVCRV 2119
Query: 722 QNSEGTAEARLRLDV----HYAPTIRALQDPTE-VNVGGSVDIVC---TVDANPILPG-- 771
+N G EA + + V H P+ + T + + S V T+D N ++PG
Sbjct: 2120 ENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQA 2179
Query: 772 --MFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRL 829
W + G + + LR+H A +G Y C V P +
Sbjct: 2180 HAQVTWHKRG--------GSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASV 2231
Query: 830 LRLVVRFAPQVEHPTPLTKVAAAGDSTS---SATLHCRARGVPNIVFTWTKNGVPLDLQD 886
LV A + P P ++ ++ + + + L C G + TW K G L +
Sbjct: 2232 --LVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR- 2288
Query: 887 PRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQT 931
HQ V S L I S A D + C A+N + + T
Sbjct: 2289 --------HQ--VRGSRLYIFQASPA-DAGQYVCRASNGMEASIT 2322
Score = 70.9 bits (172), Expect = 7e-12
Identities = 108/493 (21%), Positives = 166/493 (33%), Gaps = 89/493 (18%)
Query: 468 IGGNPEPSLMWYK-DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKF 526
+ G+P W + D R V P +++ H GS EL + + +
Sbjct: 1700 VSGSPPHYFYWSREDGRPV-----PSGTQQRHQGS----------ELHFPSVQPSDAGVY 1744
Query: 527 TCKAGQLSASTQ-----LAVQFPPTNVTILAN---ASALRPGDALNLTCVSVSSNPPVNL 578
C L S L + P +T+ + ++RPG + C + S +P L
Sbjct: 1745 ICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804
Query: 579 SWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQ-----------VSSRDHGQRVTCRAHS 627
W RL P R F G R+V L + + D G S
Sbjct: 1805 VWT----RLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
Query: 628 AELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYR 687
L V S + + +P L E S + +P P WT
Sbjct: 1861 GTLSAPVVSIHPPQLTVQPGQLAE--------------FRCSATGSPTP-TLEWT----- 1900
Query: 688 LSPAGGPRHRI-----LSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYA--P 740
GGP ++ + G L L V D Y +S G AR L VH P
Sbjct: 1901 ----GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGP 1956
Query: 741 TIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGR 800
++ + T+V+ G +V + C P W + E SL + R
Sbjct: 1957 RVQVSPERTQVHAGRTVRLYCRAAGVP--SATITWRK-----EGGSLPPQARSERTDIAT 2009
Query: 801 LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSAT 860
L I A AG Y C+ + R+ +V+ + P + + + +
Sbjct: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLD 2069
Query: 861 LHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTC 920
L+C G + TW + G L P +T+ VH S L + VS A D + C
Sbjct: 2070 LNCVVAGSAHAQVTWYRRGGSL----PPHTQ-------VHGSRLRLPQVSPA-DSGEYVC 2117
Query: 921 TATNALGSDQTNI 933
N G + +I
Sbjct: 2118 RVENGSGPKEASI 2130
Score = 51.6 bits (122), Expect = 5e-06
Identities = 95/421 (22%), Positives = 158/421 (37%), Gaps = 47/421 (11%)
Query: 545 PTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAA 604
P V + S + G + +L C VS +PP W +E R P +
Sbjct: 1676 PLVVEVHPARSIVPQGGSHSLRC-QVSGSPPHYFYWSREDGR------PVPSGTQQRHQG 1728
Query: 605 ARSVLLQVSSRDHGQRV-TCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGE 663
+ V D G + TCR L ++ +S L V P + + V ++ +
Sbjct: 1729 SELHFPSVQPSDAGVYICTCR----NLHQSNTSRAELLVTEAPS---KPITVTVEEQRSQ 1781
Query: 664 ALLP---VSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLH 720
++ P V+ ++ +T RL P + +G L + NV +D G Y
Sbjct: 1782 SVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCT 1841
Query: 721 CQN----SEGTAEARLRLDVHYAPTIRALQDPT-EVNVGGSVDIVCTVDANPILPGMFNW 775
N +GTA ++ + + ++ P V G + C+ +P +
Sbjct: 1842 GSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTG 1901
Query: 776 ERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPP-ARRLLRLVV 834
G+ + G LR+ + Y C + AR +L +
Sbjct: 1902 GPGGQLPAKAQIHG---------GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG 1952
Query: 835 RFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTY 894
P+V+ T+V A + L+CRA GVP+ TW K G L Q +E T
Sbjct: 1953 GGGPRVQVSPERTQVHAG----RTVRLYCRAAGVPSATITWRKEGGSLPPQ--ARSERT- 2005
Query: 895 HQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPD-PPSGLKVVSLT 953
+ L I ++ A D + C AT+ G+ Q IQ+V +S D P +K+ S +
Sbjct: 2006 -----DIATLLIPAITTA-DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSS 2059
Query: 954 P 954
P
Sbjct: 2060 P 2060
Score = 42.7 bits (99), Expect = 0.002
Identities = 76/312 (24%), Positives = 113/312 (36%), Gaps = 52/312 (16%)
Query: 16 LLTEG----LAQLAIPASVPRGFWALPENLTVVEGASVELRCGV-STPGSAVQWAKDGLL 70
LL +G L +IPA P+ T GASVE C V S G+ ++W K+G
Sbjct: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
Query: 71 LGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILS 130
L P + + L I+ D S Y CQ G S ++++
Sbjct: 3440 LPPGHSVQ--------------DGVLRIQNLDQSCQGTYICQ-AHGPWGKAQASAQLVIQ 3484
Query: 131 ILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVS-GDAKPAPDITILLSGQTISDISANVNE 189
L P L+ + T+ V G C++ GD KP T S + ++
Sbjct: 3485 AL-PSVLINIRTSVQTV---VVGHAVEFECLALGDPKPQ---------VTWSKVGGHLRP 3531
Query: 190 GSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPG 249
G Q R+ + C A++ A V L P I P
Sbjct: 3532 GIVQS----GGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL-----PQISMP- 3581
Query: 250 LDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPE 309
E V AG + PC+A G P + W K + E+ +++ +VRP+
Sbjct: 3582 -QEVRVPAGSAAVFPCIA-SGYPTPDISWSKLDGSLPPDSRLENNM-----LMLPSVRPQ 3634
Query: 310 DHGAQLSCEAHN 321
D G + C A N
Sbjct: 3635 DAGTYV-CTATN 3645
Score = 37.4 bits (85), Expect = 0.090
Identities = 75/336 (22%), Positives = 118/336 (35%), Gaps = 69/336 (20%)
Query: 37 LPENLTVVEGASVELRC-GVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFH 95
+PE+ +V G +V+L+C TP QW++ G +PG AR E
Sbjct: 3304 VPEHASVQAGETVQLQCLAHGTPPLTFQWSRVG------SSLPG-------RATARNEL- 3349
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQE 155
LH E D Y C+V E + L + PP L T
Sbjct: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQ---LLVQGPPGSLPAT-------------- 3392
Query: 156 YVVNCVSGDAKPAPDITILLSGQTIS-----DISANVNEGSQQKLF-----------TVE 199
+ + P +T L ++I + + G+Q + F +
Sbjct: 3393 ----SIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQD 3448
Query: 200 ATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQ 259
R+ + +C+A P +A A + L P V+ V G
Sbjct: 3449 GVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL----PSVLINIRTSVQTVVVGH 3504
Query: 260 SLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEA 319
++E C+A G+P + W K G + G + V R + V D G Q C A
Sbjct: 3505 AVEFECLAL-GDPKPQVTWSKVGGHLRP--GIVQSGGVVR---IAHVELADAG-QYRCTA 3557
Query: 320 HNSVSAGTQEHGITL-----QVTFPPSAIIILGSAS 350
N+ TQ H + L Q++ P + GSA+
Sbjct: 3558 TNAAGT-TQSHVLLLVQALPQISMPQEVRVPAGSAA 3592
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 118 bits (296), Expect = 3e-26
Identities = 150/609 (24%), Positives = 235/609 (38%), Gaps = 78/609 (12%)
Query: 470 GNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC- 528
G P P++ WYKD V + S R+ L SGS F +V ++ + C
Sbjct: 72 GRPTPTIEWYKDGERVETDKDDPRSHRMLL----PSGSLFFLRIVHGRRSKPDEGSYVCV 127
Query: 529 ------KAGQLSASTQLAV-----QFPPTNVTILANASALRPGDALNLTCVSVSSNPPVN 577
+A +AS ++A+ + PT+V + A A+ L C +P
Sbjct: 128 ARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAI-------LECQPPRGHPEPT 180
Query: 578 LSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSF 637
+ W K+ R++ R +G +++ + + TC + + E S
Sbjct: 181 IYWKKDKVRIDD---KEERISIRGG----KLMISNTRKSDAGMYTCVGTNM-VGERDSDP 232
Query: 638 YRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHR 697
L V RP FL + V +E+ V +P P W L P G R+
Sbjct: 233 AELTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQPTV-RWKKDDADL-PRG--RYD 287
Query: 698 ILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSV 757
I L + D+G Y +N G EA L V P V G +V
Sbjct: 288 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 347
Query: 758 DIVCTVDANPILPGMFNWERLGEDE---EDQSLDDMEKISRGPTGRLRIHHAKLAQAGAY 814
C NP P +F W++ G +Q + S PTG L I + + + AG Y
Sbjct: 348 TFPCETKGNP-QPAVF-WQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 405
Query: 815 QC---IVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTS---SATLHCRARGV 868
C V + A+ + V+ + P P+ A + + +A L C+A G
Sbjct: 406 ICQALTVAGSILAKAQLEVTDVL-----TDRPPPIILQGPANQTLAVDGTALLKCKATGD 460
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGS 928
P V +W K G +DPR T QG + L I+ D +TC AT++ G
Sbjct: 461 PLPVISWLKEGFTFPGRDPRAT--IQEQGTLQIKNLRIS------DTGTYTCVATSSSGE 512
Query: 929 DQTNIQL------VSISR-------PDPPSGLKVVSLTPHSVGLEWKPGFDGGLP-QRFC 974
+ L +IS+ P PPS +V +T +SV L W+PG G LP +
Sbjct: 513 TSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYI 572
Query: 975 IRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQL-PI 1033
I + + T +T+ GL+P+T ++L A+ GL+D P+
Sbjct: 573 IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNT---IYLFMVRAINPQGLSDPSPMSDPV 629
Query: 1034 TTPGLHQPS 1042
T + P+
Sbjct: 630 RTQDISPPA 638
Score = 60.5 bits (145), Expect = 1e-08
Identities = 109/518 (21%), Positives = 194/518 (37%), Gaps = 66/518 (12%)
Query: 242 PPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAV---A 298
P ++E P + V G+ L C A G P T++W K+G+ V T + + +
Sbjct: 47 PRIVEHPS--DVIVSKGEPTTLNCKAEG-RPTPTIEWYKDGERVETDKDDPRSHRMLLPS 103
Query: 299 RSVLVMTV----RPEDHGAQLSCEAHN----SVSAGTQEHGITLQVTFPPSAIIILGSAS 350
S+ + + R + C A N +VS L+ F + ++ +A
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163
Query: 351 QTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARRED 410
+ L C P + W ++ EE + + GG + +SN R+ D
Sbjct: 164 EP----AILECQPPRGHPEPTIYWKKDKVRIDDKEERI--SIRGGKLMISN----TRKSD 213
Query: 411 NGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP-----PEGQKLRAGTRVRLVC 465
G+ TC + +++ PA+ E P P Q + V C
Sbjct: 214 AGM-YTCVGTNMVGERDS----------DPAELTVFERPTFLRRPINQVVLEEEAVEFRC 262
Query: 466 LAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAK 525
+ G+P+P++ W KD + R + + + ++K+ ST + + ++N
Sbjct: 263 -QVQGDPQPTVRWKKDDADLPRGR--YDIKDDYTLRIKKTMSTDEGTYMCI---AEN--- 313
Query: 526 FTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGE 585
+ G++ AS L V+ PP V + + G + C NP + W KEG
Sbjct: 314 ---RVGKMEASATLTVRAPPQFV-VRPRDQIVAQGRTVTFPC-ETKGNPQPAVFWQKEGS 368
Query: 586 RLEGVAAPPRRAPFKGSAAARS--VLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVL 643
+ P++ + S + + + D G + C+A + ++ + +L V
Sbjct: 369 QNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYI-CQA--LTVAGSILAKAQLEVT 425
Query: 644 -----YRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRI 698
P + + T G ALL + +P P +W G+ P PR I
Sbjct: 426 DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP-VISWLKEGFTF-PGRDPRATI 483
Query: 699 LSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV 736
G L + N+ +D G Y +S G LDV
Sbjct: 484 QEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
Score = 50.1 bits (118), Expect = 1e-05
Identities = 112/514 (21%), Positives = 187/514 (36%), Gaps = 81/514 (15%)
Query: 335 QVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDG--- 391
Q FPP + ++ + TL+C ++ RP + W+ ++ ET D
Sbjct: 42 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEG-RPTPTIEWYKDGERV----ETDKDDPRS 96
Query: 392 ----LHGGHISMSNLTFLARREDNGLTLTCEA---FSEAFTKETFKKSLILNVKYPAQKL 444
L G + + R + + + C A EA ++ + +L +
Sbjct: 97 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQN-- 154
Query: 445 WIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEK 504
P + AG L C G+PEP++ W KD +V + E+
Sbjct: 155 -----PTDVVVAAGEPAILECQPPRGHPEPTIYWKKD--------------KVRIDDKEE 195
Query: 505 SGSTFSRELVLVTGPSDNQAKFTCKAGQL-----SASTQLAVQFPPTNVTILANASALRP 559
S +L++ + +TC + S +L V PT + N L
Sbjct: 196 RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE 255
Query: 560 GDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQ 619
+A+ C V +P + W K+ L P R K R + + S D G
Sbjct: 256 -EAVEFRC-QVQGDPQPTVRWKKDDADL-----PRGRYDIKDDYTLR--IKKTMSTDEGT 306
Query: 620 RVTCRAHSAELRETVSSFYRLNVLYRPEFL---GEQVLVVTAVEQGEAL-LPVSVSANPA 675
+ C A + + S+ L V P+F+ +Q+ V QG + P NP
Sbjct: 307 YM-CIAENRVGKMEASA--TLTVRAPPQFVVRPRDQI-----VAQGRTVTFPCETKGNPQ 358
Query: 676 PEAFNWTFRGYR--LSP----AGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAE 729
P F W G + L P R + +G L + N+ R+D G Y G+
Sbjct: 359 PAVF-WQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSIL 417
Query: 730 ARLRLDVHYAPTIR----ALQDPTE--VNVGGSVDIVCTVDANPILPGMFNWERLGEDEE 783
A+ +L+V T R LQ P + V G+ + C +P+ + +W L E
Sbjct: 418 AKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL--PVISW--LKEGFT 473
Query: 784 DQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCI 817
D I G L+I + +++ G Y C+
Sbjct: 474 FPGRDPRATIQE--QGTLQIKNLRISDTGTYTCV 505
Score = 38.1 bits (87), Expect = 0.053
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 836 FAPQ-VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNG--VPLDLQDPRYTEH 892
F P+ VEHP+ + + + G+ T TL+C+A G P W K+G V D DPR
Sbjct: 45 FPPRIVEHPSDV--IVSKGEPT---TLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRM 99
Query: 893 TYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG 927
G + L + + D + C A N LG
Sbjct: 100 LLPSGSLF-FLRIVHGRRSKPDEGSYVCVARNYLG 133
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 118 bits (296), Expect = 3e-26
Identities = 150/609 (24%), Positives = 235/609 (38%), Gaps = 78/609 (12%)
Query: 470 GNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC- 528
G P P++ WYKD V + S R+ L SGS F +V ++ + C
Sbjct: 56 GRPTPTIEWYKDGERVETDKDDPRSHRMLL----PSGSLFFLRIVHGRRSKPDEGSYVCV 111
Query: 529 ------KAGQLSASTQLAV-----QFPPTNVTILANASALRPGDALNLTCVSVSSNPPVN 577
+A +AS ++A+ + PT+V + A A+ L C +P
Sbjct: 112 ARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAI-------LECQPPRGHPEPT 164
Query: 578 LSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSF 637
+ W K+ R++ R +G +++ + + TC + + E S
Sbjct: 165 IYWKKDKVRIDD---KEERISIRGG----KLMISNTRKSDAGMYTCVGTNM-VGERDSDP 216
Query: 638 YRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHR 697
L V RP FL + V +E+ V +P P W L P G R+
Sbjct: 217 AELTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQPTV-RWKKDDADL-PRG--RYD 271
Query: 698 ILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSV 757
I L + D+G Y +N G EA L V P V G +V
Sbjct: 272 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 331
Query: 758 DIVCTVDANPILPGMFNWERLGEDE---EDQSLDDMEKISRGPTGRLRIHHAKLAQAGAY 814
C NP P +F W++ G +Q + S PTG L I + + + AG Y
Sbjct: 332 TFPCETKGNP-QPAVF-WQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389
Query: 815 QC---IVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTS---SATLHCRARGV 868
C V + A+ + V+ + P P+ A + + +A L C+A G
Sbjct: 390 ICQALTVAGSILAKAQLEVTDVL-----TDRPPPIILQGPANQTLAVDGTALLKCKATGD 444
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGS 928
P V +W K G +DPR T QG + L I+ D +TC AT++ G
Sbjct: 445 PLPVISWLKEGFTFPGRDPRAT--IQEQGTLQIKNLRIS------DTGTYTCVATSSSGE 496
Query: 929 DQTNIQL------VSISR-------PDPPSGLKVVSLTPHSVGLEWKPGFDGGLP-QRFC 974
+ L +IS+ P PPS +V +T +SV L W+PG G LP +
Sbjct: 497 TSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYI 556
Query: 975 IRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQL-PI 1033
I + + T +T+ GL+P+T ++L A+ GL+D P+
Sbjct: 557 IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNT---IYLFMVRAINPQGLSDPSPMSDPV 613
Query: 1034 TTPGLHQPS 1042
T + P+
Sbjct: 614 RTQDISPPA 622
Score = 60.5 bits (145), Expect = 1e-08
Identities = 109/518 (21%), Positives = 194/518 (37%), Gaps = 66/518 (12%)
Query: 242 PPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAV---A 298
P ++E P + V G+ L C A G P T++W K+G+ V T + + +
Sbjct: 31 PRIVEHPS--DVIVSKGEPTTLNCKAEG-RPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
Query: 299 RSVLVMTV----RPEDHGAQLSCEAHN----SVSAGTQEHGITLQVTFPPSAIIILGSAS 350
S+ + + R + C A N +VS L+ F + ++ +A
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
Query: 351 QTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARRED 410
+ L C P + W ++ EE + + GG + +SN R+ D
Sbjct: 148 EP----AILECQPPRGHPEPTIYWKKDKVRIDDKEERI--SIRGGKLMISN----TRKSD 197
Query: 411 NGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP-----PEGQKLRAGTRVRLVC 465
G+ TC + +++ PA+ E P P Q + V C
Sbjct: 198 AGM-YTCVGTNMVGERDS----------DPAELTVFERPTFLRRPINQVVLEEEAVEFRC 246
Query: 466 LAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAK 525
+ G+P+P++ W KD + R + + + ++K+ ST + + ++N
Sbjct: 247 -QVQGDPQPTVRWKKDDADLPRGR--YDIKDDYTLRIKKTMSTDEGTYMCI---AEN--- 297
Query: 526 FTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGE 585
+ G++ AS L V+ PP V + + G + C NP + W KEG
Sbjct: 298 ---RVGKMEASATLTVRAPPQFV-VRPRDQIVAQGRTVTFPC-ETKGNPQPAVFWQKEGS 352
Query: 586 RLEGVAAPPRRAPFKGSAAARS--VLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVL 643
+ P++ + S + + + D G + C+A + ++ + +L V
Sbjct: 353 QNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYI-CQA--LTVAGSILAKAQLEVT 409
Query: 644 -----YRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRI 698
P + + T G ALL + +P P +W G+ P PR I
Sbjct: 410 DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP-VISWLKEGFTF-PGRDPRATI 467
Query: 699 LSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV 736
G L + N+ +D G Y +S G LDV
Sbjct: 468 QEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
Score = 50.1 bits (118), Expect = 1e-05
Identities = 112/514 (21%), Positives = 187/514 (36%), Gaps = 81/514 (15%)
Query: 335 QVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDG--- 391
Q FPP + ++ + TL+C ++ RP + W+ ++ ET D
Sbjct: 26 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEG-RPTPTIEWYKDGERV----ETDKDDPRS 80
Query: 392 ----LHGGHISMSNLTFLARREDNGLTLTCEA---FSEAFTKETFKKSLILNVKYPAQKL 444
L G + + R + + + C A EA ++ + +L +
Sbjct: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQN-- 138
Query: 445 WIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEK 504
P + AG L C G+PEP++ W KD +V + E+
Sbjct: 139 -----PTDVVVAAGEPAILECQPPRGHPEPTIYWKKD--------------KVRIDDKEE 179
Query: 505 SGSTFSRELVLVTGPSDNQAKFTCKAGQL-----SASTQLAVQFPPTNVTILANASALRP 559
S +L++ + +TC + S +L V PT + N L
Sbjct: 180 RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE 239
Query: 560 GDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQ 619
+A+ C V +P + W K+ L P R K R + + S D G
Sbjct: 240 -EAVEFRC-QVQGDPQPTVRWKKDDADL-----PRGRYDIKDDYTLR--IKKTMSTDEGT 290
Query: 620 RVTCRAHSAELRETVSSFYRLNVLYRPEFL---GEQVLVVTAVEQGEAL-LPVSVSANPA 675
+ C A + + S+ L V P+F+ +Q+ V QG + P NP
Sbjct: 291 YM-CIAENRVGKMEASA--TLTVRAPPQFVVRPRDQI-----VAQGRTVTFPCETKGNPQ 342
Query: 676 PEAFNWTFRGYR--LSP----AGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAE 729
P F W G + L P R + +G L + N+ R+D G Y G+
Sbjct: 343 PAVF-WQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSIL 401
Query: 730 ARLRLDVHYAPTIR----ALQDPTE--VNVGGSVDIVCTVDANPILPGMFNWERLGEDEE 783
A+ +L+V T R LQ P + V G+ + C +P+ + +W L E
Sbjct: 402 AKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL--PVISW--LKEGFT 457
Query: 784 DQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCI 817
D I G L+I + +++ G Y C+
Sbjct: 458 FPGRDPRATIQE--QGTLQIKNLRISDTGTYTCV 489
Score = 38.1 bits (87), Expect = 0.053
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 836 FAPQ-VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNG--VPLDLQDPRYTEH 892
F P+ VEHP+ + + + G+ T TL+C+A G P W K+G V D DPR
Sbjct: 29 FPPRIVEHPSDV--IVSKGEPT---TLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRM 83
Query: 893 TYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG 927
G + L + + D + C A N LG
Sbjct: 84 LLPSGSLF-FLRIVHGRRSKPDEGSYVCVARNYLG 117
>gi|166295173 kin of IRRE like [Homo sapiens]
Length = 757
Score = 114 bits (286), Expect = 4e-25
Identities = 89/334 (26%), Positives = 142/334 (42%), Gaps = 21/334 (6%)
Query: 38 PENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLH 97
P + TVV G L C + VQW KDGL LG + +PRYR+ G G+++L
Sbjct: 27 PADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLE 86
Query: 98 IEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYV 157
I +LSDDA YECQ + L S R L++L+PP+ + + G ++ AG +
Sbjct: 87 ITDAELSDDASYECQATEA----ALRSRRAKLTVLIPPEDTRI--DGGPVILLQAGTPHN 140
Query: 158 VNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVC 217
+ C + +AKPA I G A+ K T + + P D ++ C
Sbjct: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
Query: 218 EASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQ 277
+ + A+ + + S ++V PP + ++ V+ G+ + C A + +
Sbjct: 201 RSMNEAIPSGKETSIELDVHHPPTVTL----SIEPQTVQEGERVVFTCQATANPEILGYR 256
Query: 278 WLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVT 337
W K G + A + + V S V SCE HN V G+ + V
Sbjct: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPV---------SCEVHNKV--GSTNVSTLVNVH 305
Query: 338 FPPSAIIILGSASQTENKNVTLSCVSKSSRPRVL 371
F P ++ + +VTL+CV + P L
Sbjct: 306 FAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTL 339
Score = 92.0 bits (227), Expect = 3e-18
Identities = 115/499 (23%), Positives = 187/499 (37%), Gaps = 51/499 (10%)
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR-LPQESRRVHLGSVEKSGST 508
P Q + AG R L C+ + N + W KD + + L R +GS +
Sbjct: 27 PADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAG--- 81
Query: 509 FSRELVLVTGPSDNQAKFTCKAGQL---SASTQLAVQFPPTNVTILAN-ASALRPGDALN 564
L + + A + C+A + S +L V PP + I L+ G N
Sbjct: 82 -QYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHN 140
Query: 565 LTCVSVSSNPPVNLSWDKEGERLEG-VAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTC 623
LTC + ++ P + W ++G + EG VA+ K +L+ + D G+ TC
Sbjct: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
Query: 624 RAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTF 683
R+ + + + L+V + P + + T E + +ANP + W
Sbjct: 201 RSMNEAIPSGKETSIELDV-HHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAK 259
Query: 684 RGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQ--LHCQ--NSEGTAEARLRLDVHYA 739
G+ + A R+ T D + + C+ N G+ ++VH+A
Sbjct: 260 GGFLIEDAHESRYE------------TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFA 307
Query: 740 PTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTG 799
P I PT ++G V + C NP P W + + + L + +
Sbjct: 308 PRIVVDPKPTTTDIGSDVTLTCVWVGNP--PLTLTWTK---KDSNMVLSN--------SN 354
Query: 800 RLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSA 859
+L + A AG Y C A R + L V P + + + A GD
Sbjct: 355 QLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS--SEAVQYAVRGDG---G 409
Query: 860 TLHCRARGVP---NIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
+ C P I + W +N + + + RYT + G S LTI NV A
Sbjct: 410 KVECFIGSTPPPDRIAWAWKENFLEVGTLE-RYTVERTNSGSGVLSTLTINNVMEADFQT 468
Query: 917 LFTCTATNALGSDQTNIQL 935
+ CTA N+ G IQL
Sbjct: 469 HYNCTAWNSFGPGTAIIQL 487
Score = 60.1 bits (144), Expect = 1e-08
Identities = 105/450 (23%), Positives = 173/450 (38%), Gaps = 72/450 (16%)
Query: 149 TWVAGQEYVVNCV----SGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARV 204
T VAGQ V+ CV SG + D L GQ + GS + +
Sbjct: 31 TVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSAD---AGQYNLEI 87
Query: 205 TPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHV---RAGQSL 261
T + C+A+ AL + +A TV L PP E +D G V +AG
Sbjct: 88 TDAELSDDASYECQATEAALRSR-RAKLTV--LIPP-----EDTRIDGGPVILLQAGTPH 139
Query: 262 ELPCVARGGNPLATLQWLKNGQP-----VSTAWGTEHTQAVARSVLVMTVRPEDHGAQLS 316
L C A P AT+ W ++G ST + + S L++ D G +
Sbjct: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFT 199
Query: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376
C + N +E I L V PP+ + + + E + V +C + ++ + RW
Sbjct: 200 CRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAK 259
Query: 377 GWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILN 436
G + E + + ++ S T ++CE ++ + S ++N
Sbjct: 260 GGFLI----EDAHESRYETNVDYSFFT---------EPVSCEVHNKVGSTNV---STLVN 303
Query: 437 VKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMW-YKDSRTVTESRLPQESR 495
V + A ++ ++ P + G+ V L C+ + GNP +L W KDS V +
Sbjct: 304 VHF-APRIVVDPKPTTTDI--GSDVTLTCVWV-GNPPLTLTWTKKDSNMVLSN------- 352
Query: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA-----GQLSASTQLAVQFPPTNVTI 550
S +L+L + + +TC+A G L V PP ++
Sbjct: 353 --------------SNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPI-ISS 397
Query: 551 LANASALRPGDALNLTCVSVSSNPPVNLSW 580
A A+R GD + C S+ PP ++W
Sbjct: 398 EAVQYAVR-GDGGKVECFIGSTPPPDRIAW 426
Score = 55.1 bits (131), Expect = 4e-07
Identities = 103/404 (25%), Positives = 147/404 (36%), Gaps = 61/404 (15%)
Query: 534 SASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL---EGV 590
S TQ P + T++A A+ P LN + + + W K+G L +G+
Sbjct: 16 SQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI---------VQWTKDGLALGMGQGL 66
Query: 591 AAPPRRAPFKGSAAARSVLLQVSSRDHGQRVT--CRAHSAELRETVSSFYRLNVLYRPEF 648
A PR GSA A L+++ + + C+A A LR S +L VL PE
Sbjct: 67 KAWPRYRVV-GSADAGQYNLEITDAELSDDASYECQATEAALR---SRRAKLTVLIPPED 122
Query: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALH--- 705
V ++ G + N P A FR +L G
Sbjct: 123 TRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTV 182
Query: 706 ---LWNVTRADDG-LYQLHCQNSE--GTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDI 759
L N T D G ++ N E + LDVH+ PT+ +P V G V
Sbjct: 183 SQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVF 242
Query: 760 VCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVD 819
C ANP + G + W + G ED E + ++ + C V
Sbjct: 243 TCQATANPEILG-YRWAKGGFLIEDAHESRYE---------TNVDYSFFTE--PVSCEVH 290
Query: 820 NGVAPPARRLLRLVVRFAPQ-VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKN 878
N V L + V FAP+ V P P T D S TL C G P + TWTK
Sbjct: 291 NKVGSTNVSTL-VNVHFAPRIVVDPKPTTT-----DIGSDVTLTCVWVGNPPLTLTWTKK 344
Query: 879 GVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTA 922
+ L +S+ L + +V+ A D +TC A
Sbjct: 345 DSNMVLS--------------NSNQLLLKSVTQA-DAGTYTCRA 373
>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
Length = 1349
Score = 113 bits (282), Expect = 1e-24
Identities = 144/544 (26%), Positives = 214/544 (39%), Gaps = 66/544 (12%)
Query: 520 SDNQAKFTCKAGQLSAS---------TQLAVQFPPTNVTILANASALRPGDALNLTCVSV 570
S++Q + CK L L + PPT + G ++ +TC +
Sbjct: 105 SEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAF 164
Query: 571 SSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAEL 630
+ P+ ++W KEG L A + GS SV SR+ TCRA+S +
Sbjct: 165 GNPKPI-VTWLKEGTLL---GASGKYQVSDGSLTVTSV-----SREDRGAYTCRAYSIQ- 214
Query: 631 RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSP 690
E V + + L + P F+ +T +ALL A P + W ++ +
Sbjct: 215 GEAVHTTHLL--VQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYF 272
Query: 691 AGGP--RHRILSSGALHLWNVTRADDGLYQLHCQNSEGTA-EARLRLDVHYAPTIRALQD 747
R RIL G L ++ V D G Y NS G + A L V Y + +
Sbjct: 273 QNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPP 332
Query: 748 PTEVNVGGSVDIVCTVDANPILPGMFNWERLGED---EEDQSLDDMEKISRGPTGRLRIH 804
V VG I C VDA P + W + G E++ ME G +RI
Sbjct: 333 VIYVPVGIHGYIRCPVDAEPPAT-VVKWNKDGRPLQVEKNLGWTLMED------GSIRIE 385
Query: 805 HAKLAQAGAYQCIVDN-----GVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSA 859
A G Y C+ N G + PAR +L+ F T L ++
Sbjct: 386 EATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYF-------TVLPGWEYRQEAGREL 438
Query: 860 TLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFT 919
+ C A G P V TW K G P R G + L+ +D+ +
Sbjct: 439 LIPCAAAGDPFPVITWRKVGKP-----SRSKHSALPSGSLQFRALS------KEDHGEWE 487
Query: 920 CTATNALGSDQTNIQLVSI-SRPDPPSGLKV-VSLTPHSVGLEWKPGFDGGLPQRFCIRY 977
C ATN + S + L I + P P ++V VS+T +V W+PG+DGG Q F +
Sbjct: 488 CVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVS--WEPGYDGGYEQTFSVWM 545
Query: 978 EALGTPGFHYVDV-VPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGT----QLP 1032
+ ++ + VPP + + L+P T Y+ +LA N LG S ++ T P
Sbjct: 546 KRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFP 605
Query: 1033 ITTP 1036
ITTP
Sbjct: 606 ITTP 609
Score = 60.5 bits (145), Expect = 1e-08
Identities = 103/430 (23%), Positives = 161/430 (37%), Gaps = 53/430 (12%)
Query: 407 RREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCL 466
R ED G C+ +TF +++ A + E PP+ + + G + + C
Sbjct: 104 RSEDQGW-YECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCT 162
Query: 467 AIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKF 526
A GNP+P + W K+ + S Q S GS L + + +++ +
Sbjct: 163 AF-GNPKPIVTWLKEGTLLGASGKYQVS----------DGS-----LTVTSVSREDRGAY 206
Query: 527 TCKA----GQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLS--- 579
TC+A G+ +T L VQ PP V+ N + DAL LTC + + P NL+
Sbjct: 207 TCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDAL-LTCRAEAY--PGNLTYTW 263
Query: 580 -WDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFY 638
W E + R G+ ++ +V D G + TC ++ R +S Y
Sbjct: 264 YWQDENVYFQNDLKLRVRILIDGTL----IIFRVKPEDSG-KYTCVPSNSLGRSPSASAY 318
Query: 639 RLNVLYRPEFLG-EQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHR 697
L V Y L V+ V G P V A P W G L
Sbjct: 319 -LTVQYPARVLNMPPVIYVPVGIHGYIRCP--VDAEPPATVVKWNKDGRPLQVEKNLGWT 375
Query: 698 ILSSGALHLWNVTRADDGLYQLHCQNSEGT----AEARLRL-DVHYAPTIRALQDPTEVN 752
++ G++ + T G Y N+ GT A ARL L D Y + + E
Sbjct: 376 LMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE-- 433
Query: 753 VGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAG 812
G + I C +P + W ++G+ K S P+G L+ G
Sbjct: 434 AGRELLIPCAAAGDPF--PVITWRKVGKPSR-------SKHSALPSGSLQFRALSKEDHG 484
Query: 813 AYQCIVDNGV 822
++C+ N V
Sbjct: 485 EWECVATNVV 494
Score = 40.4 bits (93), Expect = 0.011
Identities = 83/373 (22%), Positives = 140/373 (37%), Gaps = 48/373 (12%)
Query: 256 RAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVA-RSVLVMTVRPEDHGAQ 314
+ G S+ + C A G NP + WLK G T G V+ S+ V +V ED GA
Sbjct: 152 KEGGSITMTCTAFG-NPKPIVTWLKEG----TLLGASGKYQVSDGSLTVTSVSREDRGA- 205
Query: 315 LSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRW 374
+C A++ G H L V PP + + + +++ L+C +++ + W
Sbjct: 206 YTCRAYS--IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTW 263
Query: 375 WLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLI 434
+ W+ + + I + + F + ED+G TC + + S
Sbjct: 264 Y--WQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSG-KYTCVPSNSLGRSPS--ASAY 318
Query: 435 LNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQES 494
L V+YPA+ L P + G + C P + W KD R + +
Sbjct: 319 LTVQYPARVL---NMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEK----- 370
Query: 495 RRVHLG-SVEKSGSTFSRELVLVTGPSDNQAKFTC-------KAGQLSASTQLAVQFPPT 546
+LG ++ + GS E + +TC GQ SA +L ++ PP
Sbjct: 371 ---NLGWTLMEDGSIRIEE-----ATEEALGTYTCVPYNTLGTMGQ-SAPARLVLKDPPY 421
Query: 547 NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAAR 606
+ G L + C + PV ++W K G+ P R+ +
Sbjct: 422 FTVLPGWEYRQEAGRELLIPCAAAGDPFPV-ITWRKVGK--------PSRSKHSALPSGS 472
Query: 607 SVLLQVSSRDHGQ 619
+S DHG+
Sbjct: 473 LQFRALSKEDHGE 485
Score = 38.9 bits (89), Expect = 0.031
Identities = 26/83 (31%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 257 AGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLS 316
AG+ L +PC A G+P + W K G+P ++H+ + S+ + EDHG +
Sbjct: 434 AGRELLIPCAA-AGDPFPVITWRKVGKPSR----SKHSALPSGSLQFRALSKEDHG-EWE 487
Query: 317 CEAHNSVSAGTQEHGITLQVTFP 339
C A N V++ T +T+ T P
Sbjct: 488 CVATNVVTSITASTHLTVIGTSP 510
>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
Length = 600
Score = 112 bits (279), Expect = 3e-24
Identities = 100/376 (26%), Positives = 165/376 (43%), Gaps = 34/376 (9%)
Query: 3 LGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAV 62
LG R L+LG + + + V F P++ VV G V L C + V
Sbjct: 20 LGLQKRGCCLVLGYMAKDKFRRMNEGQV-YSFSQQPQDQVVVSGQPVTLLCAIPEYDGFV 78
Query: 63 QWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPEL 122
W KDGL LG + +P+Y + G+ GE HL I +L DDA YECQ + +
Sbjct: 79 LWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQA----IQAAI 134
Query: 123 VSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISD 182
S L++LVPP ++ G +++ AG + C + +AKPA I L G+ I+
Sbjct: 135 RSRPARLTVLVPPDDPVIL--GGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVING 192
Query: 183 ISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-- 240
+ + K ++ +T ++P +N Q +VC A++ A+ + S T+++ PP
Sbjct: 193 ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLV 252
Query: 241 GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
V P L++ V C A+ + +W K GQ + A G V R+
Sbjct: 253 NLSVEPQPVLEDNVV------TFHCSAKANPAVTQYRWAKRGQIIKEASG-----EVYRT 301
Query: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITL-----QVTFPPSAIIILG-----SAS 350
+ T E +SCE N++ + + + T P S ++ LG S +
Sbjct: 302 TVDYTYFSE----PVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCA 357
Query: 351 QTENKNVTLSCVSKSS 366
T N ++T+ + + S
Sbjct: 358 WTGNPSLTIVWMKRGS 373
Score = 90.5 bits (223), Expect = 9e-18
Identities = 113/500 (22%), Positives = 189/500 (37%), Gaps = 53/500 (10%)
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPS--LMWYKDSRTVTESRLPQESRRVHLGSVEKSGS 507
P+ Q + +G V L+C PE ++W KD + R + + SG
Sbjct: 54 PQDQVVVSGQPVTLLCAI----PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
Query: 508 TFSRELVLVTGPSDNQAKFTCKAGQL---SASTQLAVQFPPTNVTILAN-ASALRPGDAL 563
L ++ + A + C+A Q S +L V PP + IL +LR GD L
Sbjct: 110 ---HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPL 166
Query: 564 NLTCVSVSSNPPVNLSWDKEGERLEGVA-APPRRAPFKGSAAARSVLLQVSSRDHGQRVT 622
NLTC + ++ P ++ W ++GE + G + K + ++ + ++GQ +
Sbjct: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
Query: 623 CRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWT 682
CRA + + + +++ + P + V +E S ANPA + W
Sbjct: 227 CRATNKAIPGGKETSVTIDIQH-PPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWA 285
Query: 683 FRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQ--LHCQ--NSEGTAEARLRLDVHY 738
RG + A G +R T D + + C+ N+ G+ +DV++
Sbjct: 286 KRGQIIKEASGEVYR------------TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYF 333
Query: 739 APTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPT 798
P + V++G C NP L W + G +
Sbjct: 334 GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSL--TIVWMKRGSG-----------VVLSNE 380
Query: 799 GRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSS 858
L + + AG Y C R + L V P + + T+ A G+
Sbjct: 381 KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS--STQTQHALHGE---K 435
Query: 859 ATLHCRARGVP---NIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDY 915
+ C R P I ++W +N + RYT T S LTI+N+ A
Sbjct: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSG-RYTVETISTEEGVISTLTISNIVRADFQ 494
Query: 916 ALFTCTATNALGSDQTNIQL 935
++ CTA N+ GSD I+L
Sbjct: 495 TIYNCTAWNSFGSDTEIIRL 514
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/377 (22%), Positives = 151/377 (40%), Gaps = 55/377 (14%)
Query: 223 ALEAPIKAS-FTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKN 281
A++A I++ + VL PP PVI G +RAG L L C A P A++ WL+
Sbjct: 129 AIQAAIRSRPARLTVLVPPDDPVIL--GGPVISLRAGDPLNLTCHADNAKPAASIIWLRK 186
Query: 282 GQPVSTAWGTEHTQAVARS------VLVMTVRPED--HGAQLSCEAHNSVSAGTQEHGIT 333
G+ ++ G +++ + R V + + P D +G + C A N G +E +T
Sbjct: 187 GEVIN---GATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVT 243
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
+ + PP + + E+ VT C +K++ P V W Q++
Sbjct: 244 IDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKAN-PAVTQYRWAKRGQIIKEA-------- 294
Query: 394 GGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQ 453
G + + + + E ++CE + A +++ + Y ++ E P+
Sbjct: 295 SGEVYRTTVDYTYFSE----PVSCEV-TNALGSTNLSRTVDV---YFGPRMTTE--PQSL 344
Query: 454 KLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSV--EKSGSTFSR 511
+ G+ C A GNP +++W K V S + + L SV E +G R
Sbjct: 345 LVDLGSDAIFSC-AWTGNPSLTIVWMKRGSGVVLS----NEKTLTLKSVRQEDAGKYVCR 399
Query: 512 ELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
+V G + + T + +STQ AL G+ + C S
Sbjct: 400 AVVPRVGAGEREVTLTVNGPPIISSTQ--------------TQHALH-GEKGQIKCFIRS 444
Query: 572 SNPPVNLSWDKEGERLE 588
+ PP ++W + LE
Sbjct: 445 TPPPDRIAWSWKENVLE 461
>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
Length = 778
Score = 112 bits (279), Expect = 3e-24
Identities = 100/376 (26%), Positives = 165/376 (43%), Gaps = 34/376 (9%)
Query: 3 LGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAV 62
LG R L+LG + + + V F P++ VV G V L C + V
Sbjct: 20 LGLQKRGCCLVLGYMAKDKFRRMNEGQV-YSFSQQPQDQVVVSGQPVTLLCAIPEYDGFV 78
Query: 63 QWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPEL 122
W KDGL LG + +P+Y + G+ GE HL I +L DDA YECQ + +
Sbjct: 79 LWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQA----IQAAI 134
Query: 123 VSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISD 182
S L++LVPP ++ G +++ AG + C + +AKPA I L G+ I+
Sbjct: 135 RSRPARLTVLVPPDDPVIL--GGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVING 192
Query: 183 ISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-- 240
+ + K ++ +T ++P +N Q +VC A++ A+ + S T+++ PP
Sbjct: 193 ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLV 252
Query: 241 GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
V P L++ V C A+ + +W K GQ + A G V R+
Sbjct: 253 NLSVEPQPVLEDNVV------TFHCSAKANPAVTQYRWAKRGQIIKEASG-----EVYRT 301
Query: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITL-----QVTFPPSAIIILG-----SAS 350
+ T E +SCE N++ + + + T P S ++ LG S +
Sbjct: 302 TVDYTYFSE----PVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCA 357
Query: 351 QTENKNVTLSCVSKSS 366
T N ++T+ + + S
Sbjct: 358 WTGNPSLTIVWMKRGS 373
Score = 90.5 bits (223), Expect = 9e-18
Identities = 113/500 (22%), Positives = 189/500 (37%), Gaps = 53/500 (10%)
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPS--LMWYKDSRTVTESRLPQESRRVHLGSVEKSGS 507
P+ Q + +G V L+C PE ++W KD + R + + SG
Sbjct: 54 PQDQVVVSGQPVTLLCAI----PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
Query: 508 TFSRELVLVTGPSDNQAKFTCKAGQL---SASTQLAVQFPPTNVTILAN-ASALRPGDAL 563
L ++ + A + C+A Q S +L V PP + IL +LR GD L
Sbjct: 110 ---HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPL 166
Query: 564 NLTCVSVSSNPPVNLSWDKEGERLEGVA-APPRRAPFKGSAAARSVLLQVSSRDHGQRVT 622
NLTC + ++ P ++ W ++GE + G + K + ++ + ++GQ +
Sbjct: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
Query: 623 CRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWT 682
CRA + + + +++ + P + V +E S ANPA + W
Sbjct: 227 CRATNKAIPGGKETSVTIDIQH-PPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWA 285
Query: 683 FRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQ--LHCQ--NSEGTAEARLRLDVHY 738
RG + A G +R T D + + C+ N+ G+ +DV++
Sbjct: 286 KRGQIIKEASGEVYR------------TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYF 333
Query: 739 APTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPT 798
P + V++G C NP L W + G +
Sbjct: 334 GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSL--TIVWMKRGSG-----------VVLSNE 380
Query: 799 GRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSS 858
L + + AG Y C R + L V P + + T+ A G+
Sbjct: 381 KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS--STQTQHALHGE---K 435
Query: 859 ATLHCRARGVP---NIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDY 915
+ C R P I ++W +N + RYT T S LTI+N+ A
Sbjct: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSG-RYTVETISTEEGVISTLTISNIVRADFQ 494
Query: 916 ALFTCTATNALGSDQTNIQL 935
++ CTA N+ GSD I+L
Sbjct: 495 TIYNCTAWNSFGSDTEIIRL 514
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/377 (22%), Positives = 151/377 (40%), Gaps = 55/377 (14%)
Query: 223 ALEAPIKAS-FTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKN 281
A++A I++ + VL PP PVI G +RAG L L C A P A++ WL+
Sbjct: 129 AIQAAIRSRPARLTVLVPPDDPVIL--GGPVISLRAGDPLNLTCHADNAKPAASIIWLRK 186
Query: 282 GQPVSTAWGTEHTQAVARS------VLVMTVRPED--HGAQLSCEAHNSVSAGTQEHGIT 333
G+ ++ G +++ + R V + + P D +G + C A N G +E +T
Sbjct: 187 GEVIN---GATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVT 243
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
+ + PP + + E+ VT C +K++ P V W Q++
Sbjct: 244 IDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKAN-PAVTQYRWAKRGQIIKEA-------- 294
Query: 394 GGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQ 453
G + + + + E ++CE + A +++ + Y ++ E P+
Sbjct: 295 SGEVYRTTVDYTYFSE----PVSCEV-TNALGSTNLSRTVDV---YFGPRMTTE--PQSL 344
Query: 454 KLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSV--EKSGSTFSR 511
+ G+ C A GNP +++W K V S + + L SV E +G R
Sbjct: 345 LVDLGSDAIFSC-AWTGNPSLTIVWMKRGSGVVLS----NEKTLTLKSVRQEDAGKYVCR 399
Query: 512 ELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
+V G + + T + +STQ AL G+ + C S
Sbjct: 400 AVVPRVGAGEREVTLTVNGPPIISSTQ--------------TQHALH-GEKGQIKCFIRS 444
Query: 572 SNPPVNLSWDKEGERLE 588
+ PP ++W + LE
Sbjct: 445 TPPPDRIAWSWKENVLE 461
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 110 bits (274), Expect = 1e-23
Identities = 218/949 (22%), Positives = 383/949 (40%), Gaps = 114/949 (12%)
Query: 31 PRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDP 89
P F P + ++GA V L C + TP V W KD + +Y++ +
Sbjct: 7398 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKD------KRELRSGKKYKIMSEN 7451
Query: 90 ARGEFH-LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMV 148
H L+++A D+ EY+C+ +++G + + L PP+ + + T+V
Sbjct: 7452 FLTSIHILNVDAADIG---EYQCKA-TNDVGSDTCVGSIALK--APPRFVKKLSDISTVV 7505
Query: 149 TWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRS 208
G+E + A+P + G+ + + S N+ + + T++ + RV P +
Sbjct: 7506 ----GKEVQLQTTIEGAEPISVVWFKDKGEIVRE-SDNIWISYSENIATLQFS-RVEPAN 7559
Query: 209 SDNRQLLVCEASSPALEAPIKASF-TVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVA 267
+ C+ + +A ++ F T++VL P ++E P + V G + L C
Sbjct: 7560 AGK---YTCQIKN---DAGMQECFATLSVLEPA--TIVEKP--ESIKVTTGDTCTLECTV 7609
Query: 268 RGGNPLATLQWLKNGQPVST--AWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSA 325
G L+T +W K+G+ +++ + V+ + ++ V P D G S E N V
Sbjct: 7610 AGTPELST-KWFKDGKELTSDNKYKISFFNKVS-GLKIINVAPSDSGVY-SFEVQNPV-- 7664
Query: 326 GTQEHGITLQV---TFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLL 382
G +LQV T PPS L + +V + C S P + + W+ ++
Sbjct: 7665 GKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPP-ISVSWFHEGNEIS 7723
Query: 383 P---MEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKY 439
+ T+ D + LT E + TC A + A + E S L V+
Sbjct: 7724 SGRKYQTTLTD-------NTCALTVNMLEESDSGDYTCIATNMAGSDEC---SAPLTVRE 7773
Query: 440 PAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHL 499
P + P+ + GT V + + G P S+ W+K S + +P + V
Sbjct: 7774 PPSFVQ---KPDPMDVLTGTNVTFTSI-VKGTPPFSVSWFKGSSEL----VPGDRCNV-- 7823
Query: 500 GSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANAS 555
S+E S + EL L + ++TC +AG+ S +T L ++ P V L N
Sbjct: 7824 -SLEDSVA----ELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRL-NDY 7877
Query: 556 ALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSS- 614
++ G L L + + PP++++W K G + P +R + +S +L++ S
Sbjct: 7878 SIEKGKPLILEG-TFTGTPPISVTWKKNGINV----TPSQRCNI--TTTEKSAILEIPSS 7930
Query: 615 --RDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSA 672
D GQ C +A +++ S+ ++ P + +Q+ V A L ++
Sbjct: 7931 TVEDAGQ-YNCYIENASGKDSCSAQI---LILEPPYFVKQLEPVKVSVGDSASLQCQLAG 7986
Query: 673 NPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWN-VTRADDGLYQLHCQNSEGTAEAR 731
P +W +L P + ++ A ++N V D G Y +NS G A
Sbjct: 7987 TPEI-GVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAS 8045
Query: 732 LRLDVH---YAPTI-RALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSL 787
L V P+ R L+D E VG V C + + P +W + G+ +D
Sbjct: 8046 TFLTVQEQKLPPSFSRQLRDVQET-VGLPVVFDCAISGSE--PISVSWYKDGKPLKDSP- 8101
Query: 788 DDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDN--GVAPPARRLLRLVVRFAPQVE-HPT 844
+++ T L I + AG Y C N G A + RL+ + P +
Sbjct: 8102 -NVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLA 8160
Query: 845 PLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLL 904
P+ V SA C G I +W K+ +++ + +Y + H ++L
Sbjct: 8161 PVDAVVG-----ESADFECHVTGTQPIKVSWAKDS--REIRSGGKYQISYLENSAHLTVL 8213
Query: 905 TIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLT 953
+ + Q +TC A N +G D QL R PPS K +S T
Sbjct: 8214 KVDKGDSGQ----YTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSET 8258
Score = 109 bits (273), Expect = 1e-23
Identities = 213/944 (22%), Positives = 374/944 (39%), Gaps = 97/944 (10%)
Query: 31 PRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDP 89
P F P + ++VE + + TP ++W KD + L P+ LEG
Sbjct: 5329 PPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC----FIGLEGST 5384
Query: 90 ARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVT 149
+ L++ + D S +Y C V +++G + S +L + PPK + EA +V
Sbjct: 5385 S----FLNLYSVDASKTGQYTCHV-TNDVGSD--SCTTMLLVTEPPKFVKKL-EASKIVK 5436
Query: 150 WVAGQEYVVNC-VSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRS 208
AG + C ++G +P+I ++ ++ ++ + A ++ S
Sbjct: 5437 --AGDSSRLECKIAG----SPEIRVVWFR---NEHELPASDKYRMTFIDSVAVIQMNNLS 5487
Query: 209 SDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVAR 268
+++ +CEA +PA S + V+ P +P + E A SLE C
Sbjct: 5488 TEDSGDFICEAQNPAGST----SCSTKVIVKEPPVFSSFPPIVETLKNAEVSLE--CELS 5541
Query: 269 GGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQ 328
G P + + Q S+ ++ S+ ++ V D G + C+A N V + T
Sbjct: 5542 GTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIG-EYHCKAQNEVGSDTC 5600
Query: 329 EHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETV 388
T+++ PP + L S + + L + ++P + ++W +++ E +
Sbjct: 5601 V--CTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQP-IFVQWLKEKEEVIRESENI 5657
Query: 389 MDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEG 448
+++ L F N C+ ++ +E ++L PA + G
Sbjct: 5658 RITFVE---NVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLE---PAVIVEKAG 5711
Query: 449 PPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQES-----RRVHLGSVE 503
P + G L C + G PE S+ WYKD + +T S+ + S + + SVE
Sbjct: 5712 P---MTVTVGETCTLEC-KVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVE 5767
Query: 504 KSGS-TFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDA 562
+ + T++ ++ +N K +C A + + AV PP+ L N G
Sbjct: 5768 RQDAGTYTFQV------QNNVGKSSCTA--VVDVSDRAV--PPSFTRRLKNT-----GGV 5812
Query: 563 LNLTCV---SVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQ 619
L +C+ V+ + P++++W E ++ V+ + F + LQ++S D
Sbjct: 5813 LGASCILECKVAGSSPISVAWFHEKTKI--VSGAKYQTTFSDNVCT----LQLNSLDSSD 5866
Query: 620 RVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAF 679
+A + + L V P F+ E + V G+ + SV P
Sbjct: 5867 MGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPL--EVLPGKNVTFTSVIRGTPPFKV 5924
Query: 680 NWTFRGYRLSPAGGPRHRIL---SSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV 736
NW FRG R G R I + L L+N+ + G Y N+ G A RL V
Sbjct: 5925 NW-FRGAR-ELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFV 5982
Query: 737 HY-APTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISR 795
A ++ L D + V G S+ + T LP W++ G + ++ ++
Sbjct: 5983 KEPAAFLKRLSDHS-VEPGKSIILESTYTGT--LPISVTWKKDGFNITTSEKCNI--VTT 6037
Query: 796 GPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDS 855
T L I ++ AG Y C ++N L + V PL AA GDS
Sbjct: 6038 EKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLE--AAVGDS 6095
Query: 856 TSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDY 915
S L C+ G P I +W K L P Y TY V + + N++ + +Y
Sbjct: 6096 VS---LQCQVAGTPEITVSWYKGDTKLR-PTPEY--RTYFTNNVATLVFNKVNINDSGEY 6149
Query: 916 ALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGL 959
TC A N++G+ + R PPS + + +VGL
Sbjct: 6150 ---TCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGL 6190
Score = 106 bits (265), Expect = 1e-22
Identities = 200/918 (21%), Positives = 348/918 (37%), Gaps = 97/918 (10%)
Query: 43 VVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEAC 101
VV+ + VEL C V+ TP V W K+ + I +Y L + F+LHI C
Sbjct: 4966 VVKYSDVELECEVTGTPPFEVTWLKN------NREIRSSKKYTLTDRVS--VFNLHITKC 5017
Query: 102 DLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCV 161
D SD EY+C V +E G S RV L PP + T++ A + V
Sbjct: 5018 DPSDTGEYQCIVS-NEGGSCSCSTRVALK--EPPSFIKKIENTTTVLKSSATFQSTV--- 5071
Query: 162 SGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQ--LLVCEA 219
P IT L Q + +E + V++ A + RS DN C+A
Sbjct: 5072 --AGSPPISITWLKDDQIL-------DEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQA 5122
Query: 220 SSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWL 279
+ E+ ++ + ++ P V + +D V + L CV G P ++WL
Sbjct: 5123 KN---ESGVERCYAFLLVQEPAQIVEKAKSVD---VTEKDPMTLECVV-AGTPELKVKWL 5175
Query: 280 KNG-QPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTF 338
K+G Q V + + + + S + +V +D G ++ S+ + L
Sbjct: 5176 KDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNI 5235
Query: 339 PPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQL-LPMEETVMDGLHGGHI 397
PPS L + ++ + C S P + +W+ +++ + ++ +
Sbjct: 5236 PPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVCHERSVSL 5294
Query: 398 SMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRA 457
++NL ++ TC+ + A S IL VK P L P Q+
Sbjct: 5295 EVNNLEL-----EDTANYTCKVSNVAGDDAC---SGILTVKEPPSFL---VKPGRQQAIP 5343
Query: 458 GTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVT 517
+ V + + G P + W+KD + + +G GST L V
Sbjct: 5344 DSTVEFKAI-LKGTPPFKIKWFKDDVELV------SGPKCFIG---LEGSTSFLNLYSVD 5393
Query: 518 GPSDNQAKFTC----KAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSN 573
Q +TC G S +T L V PP V L + ++ GD+ L C ++ +
Sbjct: 5394 ASKTGQ--YTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLEC-KIAGS 5450
Query: 574 PPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRET 633
P + + W + L A+ R F S A + +S+ D G + C A + +
Sbjct: 5451 PEIRVVWFRNEHELP--ASDKYRMTFIDSVAVIQ-MNNLSTEDSGDFI-CEAQNPAGSTS 5506
Query: 634 VSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGG 693
S+ ++ P +V ++ E L +S P F + +
Sbjct: 5507 CSTKV---IVKEPPVFSSFPPIVETLKNAEVSLECELSGTP---PFEVVWYKDKRQLRSS 5560
Query: 694 PRHRILSSG---ALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTE 750
+++I S ++H+ NV +D G Y QN G+ + + P + +
Sbjct: 5561 KKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLT 5620
Query: 751 VNVGGSVDIVCTVD-ANPI-LPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKL 808
V G ++ +++ A PI + + E + + E+ + +E ++ L+ A+
Sbjct: 5621 VVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVA-----TLQFAKAEP 5675
Query: 809 AQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGV 868
A AG Y C + N +V+ A VE P+T + TL C+ G
Sbjct: 5676 ANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVG-----ETCTLECKVAGT 5730
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSA-AQDYALFTCTATNALG 927
P + W K+G L T H+ ++ + ++ +S QD +T N +G
Sbjct: 5731 PELSVEWYKDGKLL-------TSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVG 5783
Query: 928 SDQTNIQLVSISRPDPPS 945
+ R PPS
Sbjct: 5784 KSSCTAVVDVSDRAVPPS 5801
Score = 97.8 bits (242), Expect = 6e-20
Identities = 209/933 (22%), Positives = 343/933 (36%), Gaps = 117/933 (12%)
Query: 22 AQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGF 80
A L + + P F + P++LT G + + C V+ TP W KDG L P
Sbjct: 3541 ATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPS------ 3594
Query: 81 PRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLL 140
P +R+ A + L + + D Y C+ ++ G ++ +I+ I P + L
Sbjct: 3595 PNWRI--SDAENKHILELSNLTIQDRGVYSCKAS-NKFGADICQAELII-IDKPHFIKEL 3650
Query: 141 TPEAGTMVTWVAGQEYVVNC-VSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVE 199
P V ++ + C V D K +T+ T S + G K+ +
Sbjct: 3651 EP-----VQSAINKKVHLECQVDEDRK----VTV-----TWSKDGQKLPPGKDYKICFED 3696
Query: 200 --ATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPG------PPVIEWPGLD 251
AT + + VC AS+ A S TV V PP P + P
Sbjct: 3697 KIATLEIPLAKLKDSGTYVCTASNEA--GSSSCSATVTVREPPSFVKKVDPSYLMLP--- 3751
Query: 252 EGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMT-VRPED 310
G+S L C + G+P+ + W KN + +S + + ++L +T V+ ED
Sbjct: 3752 ------GESARLHCKLK-GSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVED 3804
Query: 311 HGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRV 370
G+ SCEA N V G+ + + PPS I L A N L C + P
Sbjct: 3805 SGS-YSCEAVNDV--GSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGP-F 3860
Query: 371 LLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTL---TCEAFSEAFTKE 427
+ W+ +Q+ ++ + S +L L N + C +E
Sbjct: 3861 EISWFKDKKQIRSSKKYRL-------FSQKSLVCLEIFSFNSADVGEYECVVANEVGKCG 3913
Query: 428 TFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE 487
L+ +K+ + G + + A+ G+ S+ W K + E
Sbjct: 3914 CMATHLLKEPPTFVKKV-------DDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIRE 3966
Query: 488 SRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQF 543
G ++ S S L++ K+TC +AG ++ +L V+
Sbjct: 3967 D-----------GKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVK- 4014
Query: 544 PPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSA 603
P + A + GD L +V+ P + W K+G L VA+ R FK +
Sbjct: 4015 EPAKIIERAELIQVTAGDPATLE-YTVAGTPELKPKWYKDGRPL--VASKKYRISFKNN- 4070
Query: 604 AARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGE 663
A+ D GQ ++ ++F L+ P F + + V +V G
Sbjct: 4071 VAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAP-FFTKPLRNVDSVVNGT 4129
Query: 664 ALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRIL---SSGALHLWNVTRADDGLYQLH 720
L + A P +W G + A R+RI + +L + V D G +
Sbjct: 4130 CRLDCKI-AGSLPMRVSWFKDGKEI--AASDRYRIAFVEGTASLEIIRVDMNDAGNFTCR 4186
Query: 721 CQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGE 780
NS G+ ++ L V P+ +V G +V + T + P W +
Sbjct: 4187 ATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGS--TPLTIRWFK--G 4242
Query: 781 DEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDN---GVAPPARRLLRLVVRFA 837
++E S L ++ K + +G Y C V N GV A ++ F
Sbjct: 4243 NKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFV 4302
Query: 838 PQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQ- 896
++E P+ L K GD+T L C+ G P I TW N D E + H+
Sbjct: 4303 EKLE-PSQLLK---KGDATQ---LACKVTGTPPIKITWFAN-------DREIKESSKHRM 4348
Query: 897 GGVHSSLLTIANVSAAQDYALFTCTATNALGSD 929
V S+ + +D + C A N GSD
Sbjct: 4349 SFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSD 4381
Score = 94.0 bits (232), Expect = 8e-19
Identities = 204/919 (22%), Positives = 354/919 (38%), Gaps = 91/919 (9%)
Query: 38 PENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
P ++ V+ G S + C V+ + W+KD + P G G+ HL
Sbjct: 6277 PVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPG----GNYTITCVGNTP----HL 6328
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEY 156
I D +Y CQ +++G ++ S + LS+ PPK + EA + G+
Sbjct: 6329 RILKVGKGDSGQYTCQA-TNDVGKDMCSAQ--LSVKEPPKFVKKL-EASKVAK--QGESI 6382
Query: 157 VVNC-VSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVT--PRSSDNRQ 213
+ C +SG +P+I + + ++E + + + + A +T S+++
Sbjct: 6383 QLECKISG----SPEIKVSWFRN-----DSELHESWKYNMSFINSVALLTINEASAEDSG 6433
Query: 214 LLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
+CEA + +A + TV PPV G ++ G + L C G P
Sbjct: 6434 DYICEAHNGVGDASCSTALTVKA-----PPVFTQKPSPVGALK-GSDVILQCEISGTPPF 6487
Query: 274 ATLQWLKNGQPVSTAWGTEHTQA-VARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGI 332
+ W+K+ + V + + T S+ ++ + D G + C+A N V + T +
Sbjct: 6488 EVV-WVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVG-EYHCKATNEVGSDTCSCSV 6545
Query: 333 TLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQ--LLPMEETVMD 390
+ PP + L S V L + + +P ++ WL R + E T +
Sbjct: 6546 KFKE--PPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVV--WLKDRGEVIRESENTRIS 6601
Query: 391 GLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPP 450
+ +++ L + N C+ ++A +E S +L V PA+ I P
Sbjct: 6602 FID----NIATLQLGSPEASNSGKYICQIKNDAGMREC---SAVLTVLEPAR---IIEKP 6651
Query: 451 EGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFS 510
E + G L C+ + G PE S W+KD R ++ + + S++ + S
Sbjct: 6652 EPMTVTTGNPFALECV-VTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMS 6710
Query: 511 RELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSV 570
+ + ++ K C + S ++ PP+ + L + +A+ G ++ L C V
Sbjct: 6711 DKGLYSFEVKNSVGKSNCTVS-VHVSDRIV---PPSFIRKLKDVNAIL-GASVVLEC-RV 6764
Query: 571 SSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAEL 630
S + P+++ W ++G + V+ P ++ F + ++ L S D G TC A +
Sbjct: 6765 SGSAPISVGWFQDGNEI--VSGPKCQSSFSENVCTLNLSLLEPS-DTGI-YTCVAANVAG 6820
Query: 631 RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSP 690
+ S+ L V P F EQ V G +L SV P W F+G R
Sbjct: 6821 SDECSAV--LTVQEPPSF--EQTPDSVEVLPGMSLTFTSVIRGTPPFKVKW-FKGSRELV 6875
Query: 691 AGGPRHRILSSGA--LHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDP 748
G + L L L+ V + G Y N G+A L V T
Sbjct: 6876 PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLAD 6935
Query: 749 TEVNVGGSVDIVCTVDANPILPGMFNW---ERLGEDEEDQSLDDMEKISRGPTGRLRIHH 805
V G + + T P P +W E L E S+ EK + L I
Sbjct: 6936 FSVETGSPIVLEATYTGTP--PISVSWIKDEYLISQSERCSITMTEKSTI-----LEILE 6988
Query: 806 AKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRA 865
+ + Y C+++N L V+ +E PL V A ATL C+
Sbjct: 6989 STIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIE---PLEHVEAV--IGEPATLQCKV 7043
Query: 866 RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNA 925
G P I +W K L + Y ++ + N D ++C A N+
Sbjct: 7044 DGTPEIRISWYKEHTKL------RSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNS 7097
Query: 926 LGSDQTNIQLVSISRPDPP 944
+G+ ++ LV +R PP
Sbjct: 7098 VGAVASSAVLVIKARKLPP 7116
Score = 92.4 bits (228), Expect = 2e-18
Identities = 151/704 (21%), Positives = 270/704 (38%), Gaps = 64/704 (9%)
Query: 258 GQSLELPCVARGGNPLATLQWLKNGQPV--STAWGTEHTQAVARSVLVMTVRPEDHGAQL 315
G S+ L C G P T+ W K + + + T T VA +++ V D G +
Sbjct: 6093 GDSVSLQCQV-AGTPEITVSWYKGDTKLRPTPEYRTYFTNNVA-TLVFNKVNINDSG-EY 6149
Query: 316 SCEAHNSVSAGTQEHGITLQVT-FPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRW 374
+C+A NS+ + + +Q PPS L QT VTL+C S P +
Sbjct: 6150 TCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVC-- 6207
Query: 375 WLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLI 434
W LL +E + +++ L L + +C A + T + S
Sbjct: 6208 WYRDGVLLRDDENLQTSFVD---NVATLKILQTDLSHSGQYSCSASNPLGTASS---SAR 6261
Query: 435 LNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQES 494
L + P + + + P + AG C G P + W KD++ E
Sbjct: 6262 LTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPM-RITWSKDNK---------EI 6311
Query: 495 RRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQFPPTNVTI 550
R ++ G+T +L G D+ ++TC+A G+ S QL+V+ PP V
Sbjct: 6312 RPGGNYTITCVGNT-PHLRILKVGKGDS-GQYTCQATNDVGKDMCSAQLSVKEPPKFVKK 6369
Query: 551 LANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLL 610
L + + G+++ L C +S +P + +SW + L + F S A ++
Sbjct: 6370 LEASKVAKQGESIQLEC-KISGSPEIKVSWFRNDSELH--ESWKYNMSFINSVALLTI-N 6425
Query: 611 QVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSV 670
+ S+ D G + C AH+ + S+ + P ++ V A++ + +L +
Sbjct: 6426 EASAEDSGDYI-CEAHNGVGDASCSTALTVKA---PPVFTQKPSPVGALKGSDVILQCEI 6481
Query: 671 SANPAPEAFNWTFRGYRLSPAGGPRHRILS---SGALHLWNVTRADDGLYQLHCQNSEGT 727
S P F + R + +I S +LH+ N+ +D G Y N G+
Sbjct: 6482 SGTP---PFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGS 6538
Query: 728 AEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGE---DEED 784
+ P T +G +V++ V+ + ++ +R GE + E+
Sbjct: 6539 DTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDR-GEVIRESEN 6597
Query: 785 QSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPT 844
+ ++ I+ L++ + + +G Y C + N + V+ A +E P
Sbjct: 6598 TRISFIDNIA-----TLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPE 6652
Query: 845 PLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLL 904
P+T + L C G P + W K+G L H V S +
Sbjct: 6653 PMTVTTG-----NPFALECVVTGTPELSAKWFKDGRELSADS---KHHITFINKVASLKI 6704
Query: 905 TIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLK 948
A +S D L++ N++G + + R PPS ++
Sbjct: 6705 PCAEMS---DKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIR 6745
Score = 87.0 bits (214), Expect = 1e-16
Identities = 151/696 (21%), Positives = 250/696 (35%), Gaps = 88/696 (12%)
Query: 258 GQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSC 317
G + +G P+ T+ WLK+ ++ T + L ++ H + C
Sbjct: 4500 GGTAAFQATLKGSLPI-TVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVC 4558
Query: 318 EAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWW-- 375
+A N AG Q L V P + S T+ TL V S + +W+
Sbjct: 4559 QAKND--AGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQ-VKFSGTKEITAKWFKD 4615
Query: 376 -----LGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFK 430
LG + + + +TV S L ++ + + T E ++
Sbjct: 4616 GQELTLGSKYKISVTDTV-----------SILKIISTEKKDSGEYTFEVQNDVGRSSCKA 4664
Query: 431 KSLILNVKYPAQKLWIEGPPEGQKLRA-----GTRVRLVCLAIGGNPEPSLMWYKDSRTV 485
+ +L++ P P +KL+ G+ + L C+ G +P S+ W+KD + +
Sbjct: 4665 RINVLDLIIP--------PSFTKKLKKMDSIKGSFIDLECIVAGSHPI-SIQWFKDDQEI 4715
Query: 486 TESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAV 541
+ S + S + +E S + +TC KAG S L V
Sbjct: 4716 SASEKYKFSFHDNTAFLEISQLE-----------GTDSGTYTCSATNKAGHNQCSGHLTV 4764
Query: 542 QFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKG 601
+ PP V + + P + L + V P+ + W K+ + L AA R+ +K
Sbjct: 4765 KEPPYFVE-KPQSQDVNPNTRVQLKAL-VGGTAPMTIKWFKDNKELHSGAA---RSVWKD 4819
Query: 602 SAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQ 661
+ L + D G + ++ T +S L V P+F+ + V+
Sbjct: 4820 DTSTSLELFAAKATDSGTYICQLSNDVG---TATSKATLFVKEPPQFIKKPSPVLVLRNG 4876
Query: 662 GEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRA---DDGLYQ 718
++ P +W G ++ +H I L + ++ A + G Y
Sbjct: 4877 QSTTFECQITGTPKIRV-SWYLDGNEITAI--QKHGISFIDGLATFQISGARVENSGTYV 4933
Query: 719 LHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERL 778
+N GTA + L V PT P EV V++ C V P P W L
Sbjct: 4934 CEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTP--PFEVTW--L 4989
Query: 779 GEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDN---GVAPPARRLLRLVVR 835
+ E +S R L I + G YQCIV N + R L+
Sbjct: 4990 KNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPS 5049
Query: 836 FAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYH 895
F ++E+ T + K SSAT G P I TW K+ LD D Y
Sbjct: 5050 FIKKIENTTTVLK--------SSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFV-- 5099
Query: 896 QGGVHSSLLTIANVSAAQDYA-LFTCTATNALGSDQ 930
S+ T+ S ++ +TC A N G ++
Sbjct: 5100 -----DSVATLQIRSVDNGHSGRYTCQAKNESGVER 5130
Score = 86.3 bits (212), Expect = 2e-16
Identities = 155/715 (21%), Positives = 268/715 (37%), Gaps = 76/715 (10%)
Query: 250 LDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPE 309
L E + +G S+ + C G P++ + W G +S+ + T L + + E
Sbjct: 7688 LKETNGLSGSSVVMECKVYGSPPIS-VSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEE 7746
Query: 310 DHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPR 369
+C A N AG+ E L V PPS + NVT + + K + P
Sbjct: 7747 SDSGDYTCIATNM--AGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPP- 7803
Query: 370 VLLRWWLGWRQLLP-------MEETVMD-GLHGGHISMSN-LTFLARREDNGLTLTCEAF 420
+ W+ G +L+P +E++V + L S S T + E + T +
Sbjct: 7804 FSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLY 7863
Query: 421 SEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYK 480
+A K F K L + L +EG G P S+ W K
Sbjct: 7864 IKAPAK--FVKRLNDYSIEKGKPLILEG------------------TFTGTPPISVTWKK 7903
Query: 481 DSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSAS 536
+ VT S+ R ++ + EKS L + + ++ ++ C +G+ S S
Sbjct: 7904 NGINVTPSQ------RCNITTTEKSAI-----LEIPSSTVEDAGQYNCYIENASGKDSCS 7952
Query: 537 TQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRR 596
Q+ + PP V L + GD+ +L C ++ P + +SW K +L +
Sbjct: 7953 AQILILEPPYFVKQLEPVK-VSVGDSASLQC-QLAGTPEIGVSWYKGDTKLRPTTT--YK 8008
Query: 597 APFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVV 656
F+ + A V QV D G+ + C+A ++ + S+F + P Q+ V
Sbjct: 8009 MHFRNNVATL-VFNQVDINDSGEYI-CKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDV 8066
Query: 657 TAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA-LHLWNVTRADDG 715
+ ++S + P + +W G L + + L + A L+++ R+ G
Sbjct: 8067 QETVGLPVVFDCAISGSE-PISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAG 8125
Query: 716 LYQLHCQNSEGTAEARLRL---DVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGM 772
Y N G+A + RL + P P + VG S D C V P
Sbjct: 8126 QYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQ--PIK 8183
Query: 773 FNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPA-RRLLR 831
+W + + E +S + + L + +G Y C N V + L
Sbjct: 8184 VSWAK--DSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLN 8241
Query: 832 LVVRFAPQVEHPTPLTKVAAAGDST--SSATLHCRARGVPNIVFTWTKNGVPLDLQDPRY 889
+ R P P+ +++ + T +S L R G I W KN + ++Q
Sbjct: 8242 IKERLIP----PSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNI--EIQPTSN 8295
Query: 890 TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPP 944
E T+ +++L+ + D L+TC +N GS +V PP
Sbjct: 8296 CEITFK----NNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPP 8346
Score = 83.6 bits (205), Expect = 1e-15
Identities = 160/719 (22%), Positives = 263/719 (36%), Gaps = 106/719 (14%)
Query: 278 WLKNGQPVSTAWGTEHTQAVARSV---LVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITL 334
W K+G ++ H V R + + R D G + AG +TL
Sbjct: 3179 WYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEY-------TFVAGRNRSSVTL 3231
Query: 335 QVTFP--PSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDG- 391
V P P + L + K C S RP+ + W+ E+ + G
Sbjct: 3232 YVNAPEPPQVLQELQPVTVQSGKPARF-CAVISGRPQPKISWY-------KEEQLLSTGF 3283
Query: 392 ----LHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNV--------KY 439
LH G L + ++ TCEA ++ + T SL + V +
Sbjct: 3284 KCKFLHDGQ--EYTLLLIEAFPEDAAVYTCEAKND-YGVATTSASLSVEVPEVVSPDQEM 3340
Query: 440 PAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHL 499
P I P + G R C G + + S WY + + SR +
Sbjct: 3341 PVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVS--WYSKDKKIKPSRFFR------- 3391
Query: 500 GSVEKSGSTFSRELVLVTGPSDNQAKFTCK--AGQLSASTQLAVQFPPT--------NVT 549
+ + T+ E+ + F GQ+S++ L+++ P + +
Sbjct: 3392 --MTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIE 3449
Query: 550 ILANASA-----LRP-----GDALNLTCVSVSSNPPVNLSWDKEGERL-EGVAAPPRRAP 598
+ A+ + P G TC + S P V W K G + E R +
Sbjct: 3450 MEMKAAPVIKRKIEPLEVALGHLAKFTC-EIQSAPNVRFQWFKAGREIYESDKCSIRSSK 3508
Query: 599 FKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTA 658
+ S +L+ D G+ TC+A + + ++ + Y P FL + T
Sbjct: 3509 YISSLE----ILRTQVVDCGE-YTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTF 3563
Query: 659 VEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALH---LWNVTRADDG 715
V + + +V+ P E W G LSP+ P RI + H L N+T D G
Sbjct: 3564 VGKAAKFI-CTVTGTPVIETI-WQKDGAALSPS--PNWRISDAENKHILELSNLTIQDRG 3619
Query: 716 LYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNW 775
+Y N G + L + P +P + + V + C VD + + W
Sbjct: 3620 VYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVT--VTW 3677
Query: 776 ERLGED---EEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRL 832
+ G+ +D + +KI+ L I AKL +G Y C N A + +
Sbjct: 3678 SKDGQKLPPGKDYKICFEDKIAT-----LEIPLAKLKDSGTYVCTASNE-AGSSSCSATV 3731
Query: 833 VVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEH 892
VR P + + G+S A LHC+ +G P I TW KN L +
Sbjct: 3732 TVREPPSFVKKVDPSYLMLPGES---ARLHCKLKGSPVIQVTWFKNNKELS------ESN 3782
Query: 893 TYHQGGVHS-SLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVV 950
T V+S ++L I +V +D ++C A N +GSD + ++V +PPS +K +
Sbjct: 3783 TVRMYFVNSEAILDITDVK-VEDSGSYSCEAVNDVGSDSCSTEIVI---KEPPSFIKTL 3837
Score = 79.3 bits (194), Expect = 2e-14
Identities = 194/896 (21%), Positives = 324/896 (36%), Gaps = 146/896 (16%)
Query: 31 PRGFWALPENLTVVEGASVELRCGVSTPGS-AVQWAKDGLLLGPDPRIPGFPRYRLEGDP 89
P F E +V G + L+C VS G + W KD +I +YRL
Sbjct: 3830 PPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKD------KKQIRSSKKYRLFSQ- 3882
Query: 90 ARGEFHLHIEACDLSDDAEYECQVGRSEMG-------------PELVSPRVILSILVPPK 136
+ L I + + +D EYEC V +E+G P V L L
Sbjct: 3883 -KSLVCLEIFSFNSADVGEYECVVA-NEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQT 3940
Query: 137 LLLLTPEAGT---MVTWVAGQEYVVNCVSGDAKPA----------PDITILLSGQTISDI 183
+ L G+ VTW+ GQE + G K + PD+ I G+
Sbjct: 3941 VTLQAAVRGSEPISVTWMKGQEVIRE--DGKIKMSFSNGVAVLIIPDVQISFGGKYTC-- 3996
Query: 184 SANVNEGSQQKL--FTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPG 241
A GSQ + V+ A++ R+ +L+ A PA +TV
Sbjct: 3997 LAENEAGSQTSVGELIVKEPAKIIERA----ELIQVTAGDPAT-----LEYTV------- 4040
Query: 242 PPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPV--STAWGTEHTQAVAR 299
G P +W K+G+P+ S + VA+
Sbjct: 4041 ---------------------------AGTPELKPKWYKDGRPLVASKKYRISFKNNVAQ 4073
Query: 300 SVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT-LQVTFPPSAIIILGSASQTENKNVT 358
+ + D G Q + E N V + + E T L P L + N
Sbjct: 4074 -LKFYSAELHDSG-QYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCR 4131
Query: 359 LSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCE 418
L C S P + + W+ +++ + + + G ++L + ++ TC
Sbjct: 4132 LDCKIAGSLP-MRVSWFKDGKEIAASDRYRIAFVEG----TASLEIIRVDMNDAGNFTCR 4186
Query: 419 AFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMW 478
A + +K++ S L V+ P + P + + G+ V L G P ++ W
Sbjct: 4187 ATNSVGSKDS---SGALIVQEPPSFVT---KPGSKDVLPGSAVCLKSTFQGSTPL-TIRW 4239
Query: 479 YKDSRTVTESRLPQESRRVHLGS--VEKSGSTFSRELVLVTGPSDNQAKFTCK----AGQ 532
+K ++ + GS + K S EL LV + + +TCK AG
Sbjct: 4240 FKGNKELVSG-----------GSCYITKEALESSLELYLVK--TSDSGTYTCKVSNVAGG 4286
Query: 533 LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAA 592
+ S L V+ P T V L + L+ GDA L C V+ PP+ ++W ++ +
Sbjct: 4287 VECSANLFVKEPATFVEKLEPSQLLKKGDATQLAC-KVTGTPPIKITWFANDREIK--ES 4343
Query: 593 PPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQ 652
R F S A L V D G+ + C A + + SS + ++ + ++
Sbjct: 4344 SKHRMSFVESTAVLR-LTDVGIEDSGEYM-CEAQNEAGSDHCSS---IVIVKESPYFTKE 4398
Query: 653 VLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSG--ALHLWNVT 710
+ +++ + +L V+ P P W F+ + +G + +L +
Sbjct: 4399 FKPIEVLKEYDVMLLAEVAGTP-PFEITW-FKDNTILRSGRKYKTFIQDHLVSLQILKFV 4456
Query: 711 RADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILP 770
AD G YQ N G++ R+ + P+ + T GG+ T+ + LP
Sbjct: 4457 AADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGS--LP 4514
Query: 771 GMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLL 830
W L + +E D++ L + ++ G Y C N +R
Sbjct: 4515 ITVTW--LKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAG--IQRCS 4570
Query: 831 RLVVRFAPQVEHPTPLTKVAAAGDSTSS--ATLHCRARGVPNIVFTWTKNGVPLDL 884
L+ V+ P +T+ A + D T ATL + G I W K+G L L
Sbjct: 4571 ALL-----SVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTL 4621
Score = 68.2 bits (165), Expect = 5e-11
Identities = 149/698 (21%), Positives = 268/698 (38%), Gaps = 104/698 (14%)
Query: 229 KASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTA 288
++S T+ V P P V++ L V++G+ C G P + W K Q +ST
Sbjct: 3226 RSSVTLYVNAPEPPQVLQ--ELQPVTVQSGKPARF-CAVISGRPQPKISWYKEEQLLSTG 3282
Query: 289 W-------GTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQV----- 336
+ G E+T +L++ PED A +CEA N T ++++V
Sbjct: 3283 FKCKFLHDGQEYT------LLLIEAFPED-AAVYTCEAKNDYGVATTSASLSVEVPEVVS 3335
Query: 337 ------TFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLP---MEET 387
+PP+ I L +E + C + S + + W+ +++ P T
Sbjct: 3336 PDQEMPVYPPAIITPLQDTVTSEGQPARFQC--RVSGTDLKVSWYSKDKKIKPSRFFRMT 3393
Query: 388 VMDGLHGGHISMS------NLTFLARREDNGLTLTCEAFSEA---FTKETFKKSLILNVK 438
+ + I+ + TF+A ++ T EA E ++ + + +K
Sbjct: 3394 QFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMK 3453
Query: 439 -YPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRV 497
P K IE P E + G + C I P W+K R + ES
Sbjct: 3454 AAPVIKRKIE-PLE---VALGHLAKFTC-EIQSAPNVRFQWFKAGREIYESDKCSIRSSK 3508
Query: 498 HLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQLAV--QFPPTNVTIL 551
++ S+E R V+ G ++TCKA G +S + L V +PP T L
Sbjct: 3509 YISSLE-----ILRTQVVDCG------EYTCKASNEYGSVSCTATLTVTEAYPP---TFL 3554
Query: 552 ANASALRP--GDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL 609
+ +L G A C +V+ P + W K+G AA ++ S A +
Sbjct: 3555 SRPKSLTTFVGKAAKFIC-TVTGTPVIETIWQKDG------AALSPSPNWRISDAENKHI 3607
Query: 610 LQVSS---RDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALL 666
L++S+ +D G +C+A + + + L ++ +P F+ E V +A+ + + L
Sbjct: 3608 LELSNLTIQDRGV-YSCKASNKFGADICQA--ELIIIDKPHFIKELEPVQSAINK-KVHL 3663
Query: 667 PVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRA---DDGLYQLHCQN 723
V + W+ G +L P G ++I + + A D G Y N
Sbjct: 3664 ECQVDED-RKVTVTWSKDGQKLPP--GKDYKICFEDKIATLEIPLAKLKDSGTYVCTASN 3720
Query: 724 SEGTAEARLRLDVHYAPTIRALQDPTEVNV-GGSVDIVCTVDANPILPGMFNWERLGEDE 782
G++ + V P+ DP+ + + G S + C + +P++ W + ++
Sbjct: 3721 EAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVI--QVTWFKNNKEL 3778
Query: 783 EDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEH 842
+ + M ++ L I K+ +G+Y C N V + +V++
Sbjct: 3779 SESNTVRMYFVN--SEAILDITDVKVEDSGSYSCEAVNDVGSDSCS-TEIVIK------E 3829
Query: 843 PTPLTKVAAAGDST--SSATLHCRARGVPNIVFTWTKN 878
P K D ++A L C G +W K+
Sbjct: 3830 PPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKD 3867
Score = 68.2 bits (165), Expect = 5e-11
Identities = 194/925 (20%), Positives = 336/925 (36%), Gaps = 98/925 (10%)
Query: 38 PENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
PE++ V G + L C V+ TP + +W KDG L D + ++ G L
Sbjct: 7592 PESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG--------L 7643
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEY 156
I SD Y +V + + VPP E + +G
Sbjct: 7644 KIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL----SGSSV 7699
Query: 157 VVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQL-- 214
V+ C + P ++ G IS G + + + T +T +
Sbjct: 7700 VMECKVYGSPPI-SVSWFHEGNEISS-------GRKYQTTLTDNTCALTVNMLEESDSGD 7751
Query: 215 LVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLA 274
C A++ A A TV P ++ P D V G ++ + +G P +
Sbjct: 7752 YTCIATNMAGSDECSAPLTVR----EPPSFVQKP--DPMDVLTGTNVTFTSIVKGTPPFS 7805
Query: 275 TLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPED--HGAQLSCEAHNSVSAGTQEHGI 332
+ W K + G ++ SV + + D + +C N AG
Sbjct: 7806 -VSWFKGSSELVP--GDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNE--AGKASCTT 7860
Query: 333 TLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGL 392
L + P + L S + K + L + P + + W + P + +
Sbjct: 7861 HLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPP-ISVTWKKNGINVTPSQRCNITTT 7919
Query: 393 HGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEG 452
I L + ++ C + + + LIL Y ++L E
Sbjct: 7920 EKSAI----LEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQL------EP 7969
Query: 453 QKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRE 512
K+ G L C + G PE + WYK + P + ++H + +
Sbjct: 7970 VKVSVGDSASLQC-QLAGTPEIGVSWYKGDTKLR----PTTTYKMHFRNNVAT------- 8017
Query: 513 LVLVTGPSDNQAKFTCKA----GQLSASTQLAVQ---FPPTNVTILANASALRPGDALNL 565
LV ++ ++ CKA G++SAST L VQ PP+ L + G +
Sbjct: 8018 LVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQET-VGLPVVF 8076
Query: 566 TCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRA 625
C ++S + P+++SW K+G+ L+ +P + F + A ++ + R + +C A
Sbjct: 8077 DC-AISGSEPISVSWYKDGKPLKD--SPNVQTSFLDNTATLNIFK--TDRSLAGQYSCTA 8131
Query: 626 HSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRG 685
+ + S+ L P F ++ V AV A V+ P +W
Sbjct: 8132 TNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQ-PIKVSWAKDS 8190
Query: 686 YRLSPAGGPRHRILSSGA-LHLWNVTRADDGLYQLHCQNSEG--TAEARLRLDVHYAPT- 741
+ G + L + A L + V + D G Y + N G + A+L + P
Sbjct: 8191 REIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPS 8250
Query: 742 -IRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGR 800
+ L + E G S + V + P W + + E Q + E + T
Sbjct: 8251 FTKRLSETVEETEGNSFKLEGRVAGSQ--PITVAWYK--NNIEIQPTSNCEITFKNNTLV 8306
Query: 801 LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFA--PQV--EHPTPLTKVAAAGDST 856
L++ A + AG Y C V N A A +V++ P V +H TP+T + G+
Sbjct: 8307 LQVRKAGMNDAGLYTCKVSND-AGSALCTSSIVIKEPKKPPVFDQHLTPVT--VSEGEYV 8363
Query: 857 SSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
L C +G I W K G + D ++ G +++L + +V+ A D
Sbjct: 8364 Q---LSCHVQGSEPIRIQWLKAGREIKPSDR--CSFSFASG---TAVLELRDVAKA-DSG 8414
Query: 917 LFTCTATNALGSDQTNIQLVSISRP 941
+ C A+N GSD T ++ +P
Sbjct: 8415 DYVCKASNVAGSDTTKSKVTIKDKP 8439
Score = 65.9 bits (159), Expect = 2e-10
Identities = 197/918 (21%), Positives = 337/918 (36%), Gaps = 96/918 (10%)
Query: 49 VELRCGVSTPGSA-VQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDA 107
V L C V V W+KDG ++P Y++ + L I L D
Sbjct: 3661 VHLECQVDEDRKVTVTWSKDG------QKLPPGKDYKICFEDKIAT--LEIPLAKLKDSG 3712
Query: 108 EYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKP 167
Y C +E G S V ++ PP + + M+ G+ ++C K
Sbjct: 3713 TYVCTAS-NEAGSSSCSATV--TVREPPSFVKKVDPSYLMLP---GESARLHC---KLKG 3763
Query: 168 APDITILLSGQTISDISANVNEGSQQKLFTV--EATARVTPRSSDNRQLLVCEASSPALE 225
+P I + T + ++E + +++ V EA +T ++ CEA +
Sbjct: 3764 SPVIQV-----TWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGS 3818
Query: 226 APIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPV 285
S + ++ P I+ L+ + G + L C G P + W K+ + +
Sbjct: 3819 D----SCSTEIVIKEPPSFIKT--LEPADIVRGTNALLQCEVSGTGPFE-ISWFKDKKQI 3871
Query: 286 STAWGTE-HTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAII 344
++ +Q + + + D G + C N V G T + PP+ +
Sbjct: 3872 RSSKKYRLFSQKSLVCLEIFSFNSADVG-EYECVVANEV--GKCGCMATHLLKEPPTFVK 3928
Query: 345 ILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTF 404
+ + VTL + S P + + W G + + M +G ++ L
Sbjct: 3929 KVDDLIALGGQTVTLQAAVRGSEP-ISVTWMKGQEVIREDGKIKMSFSNG----VAVLII 3983
Query: 405 LARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLV 464
+ G TC A +EA ++ + + L VK PA+ I E ++ AG L
Sbjct: 3984 PDVQISFGGKYTCLAENEAGSQTSVGE---LIVKEPAK---IIERAELIQVTAGDPATLE 4037
Query: 465 CLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVE------KSGSTFSRELVLVTG 518
+ G PE WYKD R + S+ + S + ++ ++ ++ E+ G
Sbjct: 4038 -YTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVG 4096
Query: 519 PSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNL 578
S + FT L P NV + N + L C ++ + P+ +
Sbjct: 4097 SSSCETTFTV----LDRDIAPFFTKPLRNVDSVVNGTC-------RLDC-KIAGSLPMRV 4144
Query: 579 SWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFY 638
SW K+G+ + A+ R F A+ + ++V D G TCRA ++ + S
Sbjct: 4145 SWFKDGKEI--AASDRYRIAFVEGTASLEI-IRVDMNDAG-NFTCRATNSVGSKDSSG-- 4198
Query: 639 RLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRH-- 696
L V P F+ + V G A+ S P W F+G + +GG +
Sbjct: 4199 ALIVQEPPSFVTKP--GSKDVLPGSAVCLKSTFQGSTPLTIRW-FKGNKELVSGGSCYIT 4255
Query: 697 RILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTE-VNVGG 755
+ +L L+ V +D G Y N G E L V T +P++ + G
Sbjct: 4256 KEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGD 4315
Query: 756 SVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQ 815
+ + C V P P W + ++ S M + T LR+ + +G Y
Sbjct: 4316 ATQLACKVTGTP--PIKITWFANDREIKESSKHRMSFVE--STAVLRLTDVGIEDSGEYM 4371
Query: 816 CIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTW 875
C N + ++V+ +P +V D L G P TW
Sbjct: 4372 CEAQNEAGSDHCSSI-VIVKESPYFTKEFKPIEVLKEYD----VMLLAEVAGTPPFEITW 4426
Query: 876 TKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
K+ L +Y T+ Q H L I AA D + C TN +GS +I
Sbjct: 4427 FKDNTIL-RSGRKY--KTFIQD--HLVSLQILKFVAA-DAGEYQCRVTNEVGS---SICS 4477
Query: 936 VSISRPDPPSGLKVVSLT 953
++ +PPS +K + T
Sbjct: 4478 ARVTLREPPSFIKKIEST 4495
Score = 60.1 bits (144), Expect = 1e-08
Identities = 153/715 (21%), Positives = 256/715 (35%), Gaps = 99/715 (13%)
Query: 346 LGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFL 405
LG A+Q LSC RP ++W+ ++L+ + M H LT +
Sbjct: 30546 LGEAAQ-------LSC-QIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTH----TLTVM 30593
Query: 406 ARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKL--RAGTRVRL 463
+++ TC A +E ET K L+ A + G P +K G+ +RL
Sbjct: 30594 TEEQEDEGVYTCIATNEVGEVETSSKLLL-----QATPQFHPGYPLKEKYYGAVGSTLRL 30648
Query: 464 VCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQ 523
+ IG P P++ W+ + L Q S + + + E + + T +
Sbjct: 30649 HVMYIG-RPVPAMTWFHGQK------LLQNSENITIENTEHYTHLVMKNVQRKTHAGKYK 30701
Query: 524 AKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKE 583
+ + G + A + +Q P T AL A+ +S PP D
Sbjct: 30702 VQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAV------ISWKPPA----DDG 30751
Query: 584 GERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNV- 642
G + A K A + V +S TCR L E ++R++
Sbjct: 30752 GSWITNYVVEKCEA--KEGAEWQLVSSAISV------TTCRI--VNLTENAGYYFRVSAQ 30801
Query: 643 ----LYRPEFLGEQVLVVTAVEQGEALLPVSVSA----------NPAPEAFNWTFRGYRL 688
+ P + V++ + E+ A +++A P R Y L
Sbjct: 30802 NTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYL 30861
Query: 689 SPAGGPRHRILSSGALHL----WNVTRADDGL---YQLHCQNSEGTAE-------ARLRL 734
+++ +S + ++V +GL +++ C+N G +E +
Sbjct: 30862 EKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKS 30921
Query: 735 DV-----HYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDD 789
DV H+ +R L V + +VC V +P + W R G++ L
Sbjct: 30922 DVPIQAPHFKEELRNLN----VRYQSNATLVCKVTGHP--KPIVKWYRQGKEIIADGLKY 30975
Query: 790 MEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKV 849
+ +G +L I A YQ N L V ++ P L +
Sbjct: 30976 RIQEFKGGYHQLIIASVTDDDATVYQVRATNQ-GGSVSGTASLEVEVPAKIHLPKTLEGM 31034
Query: 850 AAAGDSTSSA-TLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSL--LTI 906
A ++ G P+ V TW K +D + ++Q V S L
Sbjct: 31035 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLID-------NNGHYQVIVTRSFTSLVF 31087
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEW-KPGF 965
N +D + A N G DQ ++L PDPP G+KV ++ SV L W +P
Sbjct: 31088 PNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPAS 31147
Query: 966 DGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG 1020
DGG I E T ++ V + T +T+ L T Y+ ++A N G
Sbjct: 31148 DGGSKITNYI-VEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFG 31201
Score = 59.7 bits (143), Expect = 2e-08
Identities = 140/723 (19%), Positives = 257/723 (35%), Gaps = 115/723 (15%)
Query: 57 TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRS 116
TP +V W K+G+ + P R L I + + D +Y C + +
Sbjct: 7894 TPPISVTWKKNGINVTPSQRC--------NITTTEKSAILEIPSSTVEDAGQYNCYIENA 7945
Query: 117 EMGPELVSPRVILSILVPPKLLL-LTP------EAGTMVTWVAGQ-EYVVNCVSGDAKPA 168
G + S +++ IL PP + L P ++ ++ +AG E V+ GD K
Sbjct: 7946 S-GKDSCSAQIL--ILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLR 8002
Query: 169 PDITILLSGQ----TISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPAL 224
P T + + T+ ++N+ + +C+A +
Sbjct: 8003 PTTTYKMHFRNNVATLVFNQVDINDSGEY----------------------ICKAENSVG 8040
Query: 225 EAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQP 284
E + AS + V PP L + G + C G P++ + W K+G+P
Sbjct: 8041 E--VSASTFLTVQEQKLPPSFSRQ-LRDVQETVGLPVVFDCAISGSEPIS-VSWYKDGKP 8096
Query: 285 VSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSV-SAGTQEHGITLQVTFPPSAI 343
+ + + + + L + Q SC A N + SA + I + PP
Sbjct: 8097 LKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFD 8156
Query: 344 IILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLT 403
I L ++ C ++P + + W R++ + + L ++LT
Sbjct: 8157 IRLAPVDAVVGESADFECHVTGTQP-IKVSWAKDSREIRSGGKYQISYLENS----AHLT 8211
Query: 404 FLARREDNGLTLTCEAFSE----AFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGT 459
L + + TC A +E + T + K ++ + + EG +
Sbjct: 8212 VLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEG 8271
Query: 460 RVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVT-- 517
RV G+ ++ WYK++ + + TF +++
Sbjct: 8272 RV-------AGSQPITVAWYKNN--------------IEIQPTSNCEITFKNNTLVLQVR 8310
Query: 518 -GPSDNQAKFTCK----AGQLSASTQLAVQFP--PTNVTILANASALRPGDALNLTCVSV 570
++ +TCK AG ++ + ++ P P + G+ + L+C V
Sbjct: 8311 KAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSC-HV 8369
Query: 571 SSNPPVNLSWDKEGERLEGVAAPPRRAPFK-GSAAARSVLLQVSSRDHGQRVTCRAHSAE 629
+ P+ + W K G ++ P R F S A L V+ D G V C+A +
Sbjct: 8370 QGSEPIRIQWLKAGREIK----PSDRCSFSFASGTAVLELRDVAKADSGDYV-CKASNVA 8424
Query: 630 LRETVSSFYRLNVLYRPE--------------FLGEQVLVVTAVEQGEALLPVSVSANPA 675
+T S ++ + +P F + + VE+ A V +P
Sbjct: 8425 GSDTTKS--KVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPI 8482
Query: 676 PEAFNWTFRGYRLSPAGGPR--HRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLR 733
P WT +R GG H+ L + + T+ D GLY+ N G E+ +
Sbjct: 8483 PNV-KWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVN 8541
Query: 734 LDV 736
L V
Sbjct: 8542 LQV 8544
Score = 59.3 bits (142), Expect = 2e-08
Identities = 216/1047 (20%), Positives = 365/1047 (34%), Gaps = 134/1047 (12%)
Query: 22 AQLAIPASVPRGFWALPENLTVVEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGF 80
AQL++ P+ L + +G S++L C +S +P V W ++ D +
Sbjct: 6356 AQLSVKEP-PKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRN------DSELHES 6408
Query: 81 PRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLL 140
+Y + L I D +Y C+ + G S L++ PP
Sbjct: 6409 WKYNMSF--INSVALLTINEASAEDSGDYICE---AHNGVGDASCSTALTVKAPPVFTQK 6463
Query: 141 TPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEA 200
G + G + ++ C P + + +K
Sbjct: 6464 PSPVGAL----KGSDVILQCEISGTPPFEVVWV-----------------KDRKQVRNSK 6502
Query: 201 TARVTPRSSDNRQLLVCEASSPALEAPIKASFTV-------NVLFPPGPPVIEWPGLDEG 253
++T + D ++ +S E KA+ V +V F P ++ L +
Sbjct: 6503 KFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVK--KLSDT 6560
Query: 254 HVRAGQSLELPCVARGGNPLATLQWLKN-GQPVSTAWGTEHTQAVARSVLVMTVRPEDHG 312
G ++EL + G P++ + WLK+ G+ + + T + + L + +
Sbjct: 6561 STLIGDAVELRAIVEGFQPISVV-WLKDRGEVIRESENTRISFIDNIATLQLGSPEASNS 6619
Query: 313 AQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLL 372
+ C+ N AG +E L V P I + T L CV + P +
Sbjct: 6620 GKYICQIKND--AGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGT-PELSA 6676
Query: 373 RWWLGWRQLLPMEETVMDGLHGGHISMSNLTF-----LARREDNGLTLTCEAFSEAFTKE 427
+W+ R+L D H HI+ N A D GL +S
Sbjct: 6677 KWFKDGRELSA------DSKH--HITFINKVASLKIPCAEMSDKGL------YSFEVKNS 6722
Query: 428 TFKKSLILNVKYPAQKLWIEGPPEGQKLR-----AGTRVRLVCLAIGGNPEPSLMWYKDS 482
K + ++V + I P +KL+ G V L C G P S+ W++D
Sbjct: 6723 VGKSNCTVSVHVSDR---IVPPSFIRKLKDVNAILGASVVLECRVSGSAPI-SVGWFQDG 6778
Query: 483 RTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQ---- 538
+ Q S ++ ++ S + PSD +TC A ++ S +
Sbjct: 6779 NEIVSGPKCQSSFSENVCTLNLS----------LLEPSDTGI-YTCVAANVAGSDECSAV 6827
Query: 539 LAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL-EGVAAPPRRA 597
L VQ PP+ + L PG +L T V + PP + W K L G +
Sbjct: 6828 LTVQEPPSFEQTPDSVEVL-PGMSLTFTSV-IRGTPPFKVKWFKGSRELVPGESCNISLE 6885
Query: 598 PFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVT 657
F V + S D+ VT A SA T F + + L
Sbjct: 6886 DFVTELELFEVQ-PLESGDYSCLVTNDAGSASC--TTHLFVKEPATFVKR------LADF 6936
Query: 658 AVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILS-SGALHLWNVTRADDGL 716
+VE G ++ + P + +W Y +S + + S L + T D
Sbjct: 6937 SVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQ 6996
Query: 717 YQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWE 776
Y +N G + V P + E +G + C VD P + +W
Sbjct: 6997 YSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEI--RISWY 7054
Query: 777 RLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGV-APPARRLLRLVVR 835
+ E + +S + + L I+ + G Y C DN V A + +L + R
Sbjct: 7055 K--EHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKAR 7112
Query: 836 FAPQVEHPTPLTKVAAAGDSTS-SATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTY 894
P P K+ ++ CR G + +W K+GV L +D + ++
Sbjct: 7113 KLP----PFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLL--KDDANLQTSF 7166
Query: 895 HQGGVHSSLLTIANVSAAQDY-ALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLT 953
VH+ + T+ + Q + + C+A+N LG+ ++ +L+ PP L
Sbjct: 7167 ----VHN-VATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPP----FFDLK 7217
Query: 954 PHSVGL------EWKPGFDGGLPQRFC-IRYEALGTPGFHYVDVVPPQATTFTLTGLQPS 1006
P SV L +K G P + + PG +Y + T T+ +
Sbjct: 7218 PVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKG 7277
Query: 1007 TRYRVWLLASNALG-DSGLADKGTQLP 1032
+ ASN G DS A G Q P
Sbjct: 7278 DAGQYTCYASNIAGKDSCSAQLGVQEP 7304
Score = 58.9 bits (141), Expect = 3e-08
Identities = 175/813 (21%), Positives = 302/813 (37%), Gaps = 94/813 (11%)
Query: 30 VPRGFWALPENLTVVEGASVELRCGVSTPGSA---VQWAKDG--LLLGPDPRIPGFPRYR 84
VP F +++ + GASV L C VS GSA V W +DG ++ GP +
Sbjct: 6739 VPPSFIRKLKDVNAILGASVVLECRVS--GSAPISVGWFQDGNEIVSGP----------K 6786
Query: 85 LEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEA 144
+ + L++ + SD Y C V + G + S +L++ PP TP++
Sbjct: 6787 CQSSFSENVCTLNLSLLEPSDTGIYTC-VAANVAGSDECS--AVLTVQEPPSFEQ-TPDS 6842
Query: 145 GTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARV 204
V + G V P S + + S N+ S + T V
Sbjct: 6843 ---VEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNI---SLEDFVTELELFEV 6896
Query: 205 TPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELP 264
P S + LV + AS T ++ ++ L + V G + L
Sbjct: 6897 QPLESGDYSCLVTNDAG-------SASCTTHLFVKEPATFVK--RLADFSVETGSPIVLE 6947
Query: 265 CVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVS 324
G P++ + W+K+ +S + T ++L + + AQ SC N
Sbjct: 6948 ATYTGTPPIS-VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENE-- 7004
Query: 325 AGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPM 384
AG + V PP I L + TL C P + + W+ +L
Sbjct: 7005 AGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQC-KVDGTPEIRISWYKEHTKLRSA 7063
Query: 385 EETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKL 444
M + ++++L + +C+A + S +L +K A+KL
Sbjct: 7064 PAYKMQFKN----NVASLVINKVDHSDVGEYSCKADNSV---GAVASSAVLVIK--ARKL 7114
Query: 445 WIEGPPE-GQKLR-----AGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVH 498
PP +KL+ G V C I G+ + WYKD + + Q S +
Sbjct: 7115 ----PPFFARKLKDVHETLGFPVAFEC-RINGSEPLQVSWYKDGVLLKDDANLQTSFVHN 7169
Query: 499 LGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQLSASTQLAV---QFPPTNVTIL 551
+ +++ +L T S + ++ C A G S+S +L + + PP +
Sbjct: 7170 VATLQ----------ILQTDQS-HIGQYNCSASNPLGTASSSAKLILSEHEVPPF-FDLK 7217
Query: 552 ANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQ 611
+ L G++ C V+ P+ ++W K+ + + + A +VL +
Sbjct: 7218 PVSVDLALGESGTFKC-HVTGTAPIKITWAKDNREIR--PGGNYKMTLVENTATLTVL-K 7273
Query: 612 VSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVS 671
V D GQ TC A + +++ S+ +L V P F+ + L + + + +
Sbjct: 7274 VGKGDAGQ-YTCYASNIAGKDSCSA--QLGVQEPPRFIKK--LEPSRIVKQDEFTRYECK 7328
Query: 672 ANPAPEA-FNWTFRGYRLSPAGGPRHRILSSGA-LHLWNVTRADDGLYQLHCQNSEGTAE 729
+PE W + + R + S A L + N++ D G Y N+ G+A
Sbjct: 7329 IGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSAS 7388
Query: 730 ARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDD 789
+ L V P R P E G V + C + P P +W + + E +S
Sbjct: 7389 SSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTP--PFHVSWYK--DKRELRSGKK 7444
Query: 790 MEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGV 822
+ +S + I + A G YQC N V
Sbjct: 7445 YKIMSENFLTSIHILNVDAADIGEYQCKATNDV 7477
Score = 58.2 bits (139), Expect = 5e-08
Identities = 51/183 (27%), Positives = 80/183 (43%), Gaps = 18/183 (9%)
Query: 869 PNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGS 928
PNI +W K+G PL E T S++L I + D+ +T TATN+ G+
Sbjct: 24341 PNI--SWVKDGEPLKQTTRVNVEET-----ATSTVLHIKEGNK-DDFGKYTVTATNSAGT 24392
Query: 929 DQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWK-PGFDGGLP-QRFCIRYEALGTPGF 985
N+ ++ + +P PP G ++ ++ V + W+ P + GG + + T +
Sbjct: 24393 ATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTW 24452
Query: 986 HYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKG---TQLPITTPGLHQPS 1042
H V + TT +T L+ T Y+ + A N G S D Q P PG P
Sbjct: 24453 HMVSATVAR-TTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPG---PP 24508
Query: 1043 GEP 1045
G P
Sbjct: 24509 GTP 24511
Score = 57.8 bits (138), Expect = 6e-08
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 20/187 (10%)
Query: 867 GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQ--DYALFTCTATN 924
G P TWTK+G+PL + T S LT ++ D + T N
Sbjct: 23255 GRPKPTITWTKDGLPL--------KQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVAN 23306
Query: 925 ALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWKPG-FDGGLP-QRFCIRYEALG 981
+G +I++V++ +PDPP G +K ++ S+ L W P + GG + ++
Sbjct: 23307 VVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTT 23366
Query: 982 TPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKG---TQLPITTPGL 1038
T + V + TT +T L+ T Y+ + A N G S + Q P PG
Sbjct: 23367 TTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPG- 23424
Query: 1039 HQPSGEP 1045
P G P
Sbjct: 23425 --PPGTP 23429
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/310 (23%), Positives = 118/310 (38%), Gaps = 25/310 (8%)
Query: 818 VDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTK 877
V+ GV P +LR+ A V P+ +++ A D T+ + IV K
Sbjct: 14346 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDI--IVIEGEK 14403
Query: 878 NGVPLDLQDPRYTEHTYHQGGVH---SSLLTIAN----------VSAAQDYALFTCTATN 924
+P+ + ++H+ G S LT+ N S D ++T T N
Sbjct: 14404 LSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLEN 14463
Query: 925 ALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLP-QRFCIRYEALGT 982
LGS +I + I P P +K +T S L W+ P FDGG P + + G
Sbjct: 14464 KLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGR 14523
Query: 983 PGFHYVDVVPPQ-ATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQP 1041
Y+ V+ + ++T+ L P+ Y + A N +G + + P+ QP
Sbjct: 14524 R--TYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIE--LKNPVIAQDPKQP 14579
Query: 1042 SGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLL--LSNASCVGGVLWQRRLRRLAEGISE 1099
P D P + + P L+ G ++ + G W+R L I
Sbjct: 14580 PDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP-ILT 14638
Query: 1100 KTEAGSEEDR 1109
T G EE +
Sbjct: 14639 YTAKGLEEGK 14648
Score = 54.3 bits (129), Expect = 7e-07
Identities = 48/185 (25%), Positives = 77/185 (41%), Gaps = 16/185 (8%)
Query: 867 GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNAL 926
G P TW K+ VPL + T + ++SLLTI + + +D + TN+
Sbjct: 22173 GRPTPAVTWHKDNVPL-----KQTTRVNAESTENNSLLTIKD-ACREDVGHYVVKLTNSA 22226
Query: 927 GSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTP 983
G + ++ + +P PP+G +K+ +T S+ L W P +DGG + + T
Sbjct: 22227 GEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTT 22286
Query: 984 GFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKG---TQLPITTPGLHQ 1040
+ V + TT L+ Y+ + A N G S + Q P PG
Sbjct: 22287 TWQIVSATVAR-TTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPG--- 22342
Query: 1041 PSGEP 1045
P G P
Sbjct: 22343 PPGTP 22347
Score = 53.9 bits (128), Expect = 9e-07
Identities = 62/230 (26%), Positives = 96/230 (41%), Gaps = 25/230 (10%)
Query: 821 GVAPPARRLLRLVVRFAPQVEHPT------PLTKVAAAGDSTSSATLHCRARGVPNIVFT 874
G++ P LL ++++ Q+E P P V S + + +P + T
Sbjct: 26454 GLSDPRELLLPVLIK--EQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKV--T 26509
Query: 875 WTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTI-ANVSAAQDYALFTCTATNALGSDQTNI 933
+++GVPL TE T LTI S D + TA N+ G+ + I
Sbjct: 26510 LSRDGVPLKATMRFNTEITAEN-------LTINLKESVTADAGRYEITAANSSGTTKAFI 26562
Query: 934 QLVSISRPDPPSGLKVVS-LTPHSVGLEWK-PGFDGGLP-QRFCIRYEALGTPGFHYVDV 990
+V + RP PP+G V+S +T SV L+W+ P +DGG + + T + V
Sbjct: 26563 NIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSA 26622
Query: 991 VPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKG---TQLPITTPG 1037
+ T + L Y+ + A N G S D +LP TTPG
Sbjct: 26623 TVAR-TMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPG 26671
Score = 53.1 bits (126), Expect = 2e-06
Identities = 61/260 (23%), Positives = 97/260 (37%), Gaps = 19/260 (7%)
Query: 717 YQLHCQNSEGTAEAR-------LRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPIL 769
+++ +N G + R +L AP IR +G + + C + P L
Sbjct: 30503 FRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRP-L 30561
Query: 770 PGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRL 829
P + W R G++ M S G T L + + G Y CI N V
Sbjct: 30562 PDI-KWYRFGKELIQSRKYKMS--SDGRTHTLTVMTEEQEDEGVYTCIATNEVGE-VETS 30617
Query: 830 LRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRY 889
+L+++ PQ HP K G S+ LH G P TW L +
Sbjct: 30618 SKLLLQATPQF-HPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENIT 30676
Query: 890 TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSG-LK 948
E+T H + L + NV + +N G+ + + +PD P+G +
Sbjct: 30677 IENTEHY-----THLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIV 30731
Query: 949 VVSLTPHSVGLEWKPGFDGG 968
+ +L +S + WKP D G
Sbjct: 30732 IEALLKNSAVISWKPPADDG 30751
Score = 51.2 bits (121), Expect = 6e-06
Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 7/104 (6%)
Query: 866 RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNA 925
RGVP WT +G + D YT T + SS+LTI N +D + T +NA
Sbjct: 17535 RGVPVPTAKWTTDGSEIKT-DEHYTVETDN----FSSVLTIKNC-LRRDTGEYQITVSNA 17588
Query: 926 LGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWKPGFDGG 968
GS + L + P PP+G + ++ +TP + + W+P D G
Sbjct: 17589 AGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDG 17632
Score = 49.7 bits (117), Expect = 2e-05
Identities = 158/728 (21%), Positives = 276/728 (37%), Gaps = 96/728 (13%)
Query: 44 VEGASVELRCGVS-TPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACD 102
V G S + C V+ T V WAKD I +Y++ HL + D
Sbjct: 8165 VVGESADFECHVTGTQPIKVSWAKDSR------EIRSGGKYQISY--LENSAHLTVLKVD 8216
Query: 103 LSDDAEYECQVGRSEMGPELVSPRV-ILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCV 161
D +Y C +E+G + + ++ I L+PP T V G + +
Sbjct: 8217 KGDSGQYTCYAV-NEVGKDSCTAQLNIKERLIPPSF---TKRLSETVEETEGNSFKLEGR 8272
Query: 162 SGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASS 221
++P IT+ I +I N K T+ +V ++ L C+ S+
Sbjct: 8273 VAGSQP---ITVAWYKNNI-EIQPTSNCEITFKNNTL--VLQVRKAGMNDAGLYTCKVSN 8326
Query: 222 PALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKN 281
A A +S + P PPV + L V G+ ++L C +G P+ +QWLK
Sbjct: 8327 DAGSALCTSSIVIKE--PKKPPVFD-QHLTPVTVSEGEYVQLSCHVQGSEPIR-IQWLKA 8382
Query: 282 GQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQ------ 335
G+ + + + A +VL + + C+A N + T + +T++
Sbjct: 8383 GREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVA 8442
Query: 336 -VTFPPSAIIILGSASQTENKNV----TLSCVSK-SSRPRVLLRWWLG-WRQLLPMEETV 388
T + L S+ ++ V T + ++K P ++W G WRQL
Sbjct: 8443 PATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLN------ 8496
Query: 389 MDGLHGGHISMSNLTFLARREDNGLTLT------CEAFSEAFTKETFKKSLILNVKYPAQ 442
GG + + A+ E T T C AF+E E+ ++ L V +
Sbjct: 8497 ----QGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIES---NVNLQVDERKK 8549
Query: 443 KLWIEGPPEGQ-------KLRAGTRVRLVCLAIGGNPEPS-LMWYKDSRTVTESRLPQES 494
+ IEG K AG + + + N +P Y +T+ R ++
Sbjct: 8550 QEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKYARMYGITDFRGLLQA 8609
Query: 495 RRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANA 554
+ S E+ T E+ + ++ +F + +L+ P T + + N
Sbjct: 8610 FELLKQSQEEE--THRLEIEEIERSERDEKEFEELVSFIQQ--RLSQTEPVTLIKDIENQ 8665
Query: 555 SALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSS 614
+ L+ DA+ + ++ P + LSW K E+LE P + F+ S L+V +
Sbjct: 8666 TVLKDNDAVFEIDIKINY-PEIKLSWYKGTEKLE----PSDK--FEISIDGDRHTLRVKN 8718
Query: 615 ---RDHGQ-RVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSV 670
+D G R+ C H A + TV E E+ L +++G+
Sbjct: 8719 CQLKDQGNYRLVCGPHIASAKLTVI-----------EPAWERHLQDVTLKEGQTCTMTCQ 8767
Query: 671 SANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALH---LWNVTRADDGLYQLHCQNSEGT 727
+ P ++ W G L P G RH+ +H + +V D G Y ++ E +
Sbjct: 8768 FSVPNVKS-EWFRNGRILKPQG--RHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETS 8824
Query: 728 AEARLRLD 735
AE R+ +
Sbjct: 8825 AELRIEAE 8832
Score = 49.7 bits (117), Expect = 2e-05
Identities = 84/403 (20%), Positives = 149/403 (36%), Gaps = 64/403 (15%)
Query: 693 GPRHRILSSGALH---LWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPT 749
G +H+++S G +H + ++ D G Y+ ++ E AR +L++ AP I+
Sbjct: 12954 GDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKE----ARAKLELAAAPKIKTADQDL 13009
Query: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
V+VG + +V DA P W + E +++D + RI AK
Sbjct: 13010 VVDVGKPLTMVVPYDAYP--KAEAEWFKENEPLSTKTID-----TTAEQTSFRILEAKKG 13062
Query: 810 QAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCR---AR 866
G Y+ ++ N A + L V ++ P P+ + +L
Sbjct: 13063 DKGRYKIVLQNKHG-KAEGFINLKV-----IDVPGPVRNLEVTETFDGEVSLAWEEPLTD 13116
Query: 867 GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNAL 926
G I+ G ++ +D + S T+ + LF +A N +
Sbjct: 13117 GGSKII------GYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRV 13170
Query: 927 GSD---QTNIQLVSISR---PDPPSGLKVVSLTPHSVGLEWK-PGFDGG---------LP 970
G+ +T+ + + S+ P PP + + + V L W+ P +DGG L
Sbjct: 13171 GTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELR 13230
Query: 971 QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQ 1030
+ IR++ T V + + T+T + Y + A N +G G T
Sbjct: 13231 DKTSIRWDTAMT--------VRAEDLSATVTDVVEGQEYSFRVRAQNRIG-VGKPSAATP 13281
Query: 1031 LPITTPGLHQPS----------GEPEDQLPTEPPSGPSGLPLL 1063
+ +PS + QL EPP G P+L
Sbjct: 13282 FVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPIL 13324
Score = 48.9 bits (115), Expect = 3e-05
Identities = 40/188 (21%), Positives = 77/188 (40%), Gaps = 19/188 (10%)
Query: 866 RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAA--QDYALFTCTAT 923
+G P W K+G L + T S +T ++ A +D + +
Sbjct: 25419 KGRPQATVNWRKDGQTL--------KETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVS 25470
Query: 924 NALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLP-QRFCIRYEALG 981
N+ GS I ++ + RP PP +++ ++ S+ + W P +DGG + + +
Sbjct: 25471 NSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETT 25530
Query: 982 TPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKG---TQLPITTPGL 1038
+ +H V + T+ + L + Y+ + A N G S ++ + P + PG
Sbjct: 25531 STTWHIVSQAVAR-TSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPG- 25588
Query: 1039 HQPSGEPE 1046
P G P+
Sbjct: 25589 --PPGTPK 25594
Score = 48.5 bits (114), Expect = 4e-05
Identities = 111/443 (25%), Positives = 155/443 (34%), Gaps = 80/443 (18%)
Query: 666 LPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSS-GALHLWNVTRADDGLYQLHCQNS 724
L +V P P +W G L PA G + + + L L++V R D G Y + +NS
Sbjct: 19315 LDATVFGKPMPTV-SWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENS 19373
Query: 725 EGTAEARLRLDVHYAPTIRA-------------LQDPTEVNVGGSVDIVCTVDANPILPG 771
G+ A ++L V P A L + GGS VD
Sbjct: 19374 SGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRET--S 19431
Query: 772 MFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAG----AYQCIVDNGVAPPAR 827
NW ++ S +EK+ G + RI G I N PP R
Sbjct: 19432 RPNWAQVSATVPITSCS-VEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGR 19490
Query: 828 RLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTK-NGVPLDLQD 886
++ +H T K A D S T + + V WTK N P+
Sbjct: 19491 CDPPVISNITK--DHMTVSWK-PPADDGGSPITGYLLEKRETQAV-NWTKVNRKPI---- 19542
Query: 887 PRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQ-TNIQLVSISR----- 940
E T G+ +Y F TA N G + ++ + +R
Sbjct: 19543 ---IERTLKATGLQEGT----------EYE-FRVTAINKAGPGKPSDASKAAYARDPQYP 19588
Query: 941 PDPPSGLKVVSLTPHSVGLEW-KPGFDGGLPQRFCIRY--EALGTPGFHYVDVVPPQ--- 994
P PP+ KV T SV L W KP +DGG P I Y E ++V PQ
Sbjct: 19589 PGPPAFPKVYDTTRSSVSLSWGKPAYDGGSP---IIGYLVEVKRADSDNWVRCNLPQNLQ 19645
Query: 995 ATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTE-- 1052
T F +TGL T+Y+ + A N +G S PS P+ P +
Sbjct: 19646 KTRFEVTGLMEDTQYQFRVYAVNKIGYS-----------------DPSDVPDKHYPKDIL 19688
Query: 1053 -PPSGPSGLPLLPVLFALGGLLL 1074
PP G L L G+ +
Sbjct: 19689 IPPEGELDADLRKTLILRAGVTM 19711
Score = 48.1 bits (113), Expect = 5e-05
Identities = 62/250 (24%), Positives = 94/250 (37%), Gaps = 44/250 (17%)
Query: 843 PTPLTKVAAAGDST---SSATLHCRA--RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQG 897
PT +++ GD+ + +H A G+P W+KN ++ P +
Sbjct: 15395 PTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIE--KPTDALQITKEE 15452
Query: 898 GVHSSLLTIANVSAA--QDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPH 955
S T ++ A +D +T TA+N LGS N+ + RP PP L V +
Sbjct: 15453 VSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAE 15512
Query: 956 SVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYV----DVVPPQATTFTLTGLQPSTRYRV 1011
S L W D G G+ HYV D +A +T RY +
Sbjct: 15513 SCYLTWDAPLDNG------------GSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGI 15560
Query: 1012 WLLASN--------ALGDSGLAD--KGTQLPITTP-GLHQPSGEPEDQLPTE-------- 1052
W L N A+ G++D K ++ I P L P G+P+ T+
Sbjct: 15561 WKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWT 15620
Query: 1053 PPSGPSGLPL 1062
PP G P+
Sbjct: 15621 PPLDNGGSPI 15630
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 12/188 (6%)
Query: 867 GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNAL 926
G P TWTK + L QD R T + S +TI + S D + A N
Sbjct: 13716 GKPEPKITWTKADMILK-QDKRITIENVPK----KSTVTIVD-SKRSDTGTYIIEAVNVC 13769
Query: 927 GSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQ--RFCIRYEALGTPG 984
G +++ + +P PP+ + +T S L W P D G + + + A +
Sbjct: 13770 GRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEV 13829
Query: 985 FHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGE 1044
+H + + T F T L P+ Y + A N G+ + PIT P G
Sbjct: 13830 WHKLSST-VKDTNFKATKLIPNKEYIFRVAAENMY---GVGEPVQASPITAKYQFDPPGP 13885
Query: 1045 PEDQLPTE 1052
P P++
Sbjct: 13886 PTRLEPSD 13893
Score = 46.6 bits (109), Expect = 1e-04
Identities = 46/194 (23%), Positives = 79/194 (40%), Gaps = 8/194 (4%)
Query: 857 SSATLHCRARGVPNIVFTWTKNGVPL-DLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDY 915
++ + + +GVP TW K D ++P + ++ V + + S D
Sbjct: 16132 TNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDT 16191
Query: 916 ALFTCTATNALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWKPGFDGGLPQ--R 972
L+T TA N LG+ ++L + RP PP G +K S++ + L W P D G +
Sbjct: 16192 GLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITN 16251
Query: 973 FCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLP 1032
+ I + +V P + T+T+ L Y ++A N G+ + P
Sbjct: 16252 YVIEKREANRKTWVHVSSEPKEC-TYTIPKLLEGHEYVFRIMAQNKY---GIGEPLDSEP 16307
Query: 1033 ITTPGLHQPSGEPE 1046
T L G P+
Sbjct: 16308 ETARNLFSVPGAPD 16321
Score = 45.8 bits (107), Expect = 3e-04
Identities = 63/249 (25%), Positives = 104/249 (41%), Gaps = 28/249 (11%)
Query: 899 VHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSIS------RPDPPSGLKVVSL 952
V+ + L + ++ DY F TA NA G+ + + IS P PPS +VV
Sbjct: 29295 VYDTRLKVTSLMEGCDYQ-FRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDT 29353
Query: 953 TPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDV-VPPQATTFTLTGLQPSTRY 1009
T HS+ L W KP +DGG + + + T ++ V + T FT+ L+ +Y
Sbjct: 29354 TKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKY 29413
Query: 1010 RVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFAL 1069
+ A N G S ++ ++ EP +++ L + A
Sbjct: 29414 SFRVAAVNVKGMSEYSESIAEI------------EPVERIEIPDLELADDLKKTVTIRAG 29461
Query: 1070 GGLLLLSNAS--CVGGVLWQRRLRRLA-EGISEKTEAGS--EEDRVRNEYEESQWTGERD 1124
L L+ + S + W ++ LA I + TE+ S D+V N Y+ ++T E +
Sbjct: 29462 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKV-NRYDAGKYTIEAE 29520
Query: 1125 TQSSTVSTT 1133
QS S T
Sbjct: 29521 NQSGKKSAT 29529
Score = 45.4 bits (106), Expect = 3e-04
Identities = 43/166 (25%), Positives = 64/166 (38%), Gaps = 11/166 (6%)
Query: 857 SSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
+S L G P V TW+K G+ L + T +Y SLL + V+ D
Sbjct: 29462 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESY-------SLLIVDKVNR-YDAG 29513
Query: 917 LFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLP-QRFC 974
+T A N G + + P P +KV ++ SV + W+ P DGG P +
Sbjct: 29514 KYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYI 29573
Query: 975 IRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG 1020
+ F V T + ++GL T Y +L N G
Sbjct: 29574 VEKREAAMRAFKTV-TTKCSKTLYRISGLVEGTMYYFRVLPENIYG 29618
Score = 44.7 bits (104), Expect = 6e-04
Identities = 74/363 (20%), Positives = 136/363 (37%), Gaps = 34/363 (9%)
Query: 709 VTRADDG---LYQLHCQNSEGTAEARLRL------DVHYAPTIRALQDPTE---VNVGGS 756
VT ++G L+++ QN +G +E R + D+ PTI P + V G
Sbjct: 29696 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRP 29755
Query: 757 VDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQC 816
V++V + P P +W G + +E ++ +L I + G Y
Sbjct: 29756 VELVIPIAGRP--PPAASWFFAGSKLRESERVTVETHTK--VAKLTIRETTIRDTGEYTL 29811
Query: 817 IVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWT 876
+ N + + +++ P + ++ A + S P +
Sbjct: 29812 ELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEP--------PELDGGAP 29863
Query: 877 KNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG-SDQTNIQL 935
+G ++ +D V S ++ +Y +F ATN G ++
Sbjct: 29864 LSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEY-VFRVAATNRFGIGSYLQSEV 29922
Query: 936 V----SISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQ--RFCIRYEALGTPGFHYVD 989
+ SI P PP L++ ++ + L W P D G Q + + + + + V+
Sbjct: 29923 IECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVN 29982
Query: 990 VVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQL 1049
VP T + TGL Y + A NA G SG + ++ PI P G+P++
Sbjct: 29983 KVPVTMTRYRSTGLTEGLEYEHRVTAINARG-SGKPSRPSK-PIVAMDPIAPPGKPQNPR 30040
Query: 1050 PTE 1052
T+
Sbjct: 30041 VTD 30043
Score = 44.3 bits (103), Expect = 7e-04
Identities = 48/155 (30%), Positives = 66/155 (42%), Gaps = 28/155 (18%)
Query: 917 LFTCTATNALG-SDQTNIQLVSISR-----PDPPSGLKVVSLTPHSVGLEWK-PGFDGGL 969
+F A NA+G SD T I+ +++ P PP L VV +T V L+W+ P DGG
Sbjct: 14154 VFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGR 14213
Query: 970 P-QRFCI-RYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADK 1027
P QR+ I + E LGT P F +T + T + + A N
Sbjct: 14214 PIQRYVIEKKERLGTRWVKAGKTAGPDC-NFRVTDVIEGTEVQFQVRAEN---------- 14262
Query: 1028 GTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPL 1062
G+ PS EP + L E P+ P PL
Sbjct: 14263 -------EAGVGHPS-EPTEILSIEDPTSPPSPPL 14289
Score = 44.3 bits (103), Expect = 7e-04
Identities = 36/125 (28%), Positives = 55/125 (44%), Gaps = 9/125 (7%)
Query: 906 IANVSAAQDYALFTCTATNALG----SDQTNIQLVS--ISRPDPPSGLKVVSLTPHSVGL 959
+ N+ +Y F TA N G +D L S +S PDPP L+V +T +S L
Sbjct: 18759 VTNLVPGNEY-YFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 18817
Query: 960 EWKPGF-DGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASN 1017
W P DGG + Y P + + + + +TGL+ +Y+ + A N
Sbjct: 18818 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 18877
Query: 1018 ALGDS 1022
A+G S
Sbjct: 18878 AVGVS 18882
Score = 44.3 bits (103), Expect = 7e-04
Identities = 41/144 (28%), Positives = 59/144 (40%), Gaps = 20/144 (13%)
Query: 904 LTIANVSAAQDYALFTCTATNALGSDQTNIQLV------SISRPDPPSGLKVVSLTPHSV 957
L + ++ Y F A NA G + + V ++ P PPS KV + SV
Sbjct: 24961 LRVTGLTEGHSYE-FRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSV 25019
Query: 958 GLEW-KPGFDGGLPQRFCIRYEALGTPGFHYVDVVPP---QATTFTLTGLQPSTRYRVWL 1013
L W KP +DGG P + + E + PP Q FT+T L+ +T Y +
Sbjct: 25020 SLAWSKPIYDGGAPVKGYV-VEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRI 25078
Query: 1014 LASNALGDSGLADKGTQLPITTPG 1037
A N+ +G P T PG
Sbjct: 25079 CAINS--------EGVGEPATLPG 25094
Score = 44.3 bits (103), Expect = 7e-04
Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 12/125 (9%)
Query: 847 TKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTI 906
T + AG S + T+ R R VPN++ W+K DL+ Y + T + + LTI
Sbjct: 26195 TLIVKAGASFTM-TVPFRGRPVPNVL--WSKPDT--DLRTRAYVDTTDSR-----TSLTI 26244
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGF 965
N + D +T T N L + + + + P PP+ + V +T S L W P
Sbjct: 26245 ENANR-NDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPEN 26303
Query: 966 DGGLP 970
DGG P
Sbjct: 26304 DGGAP 26308
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/89 (30%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 938 ISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQA 995
I++P PP + + T +SV L W+ P DGG + + Y+ +G + + P
Sbjct: 17110 IAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESC 17169
Query: 996 --TTFTLTGLQPSTRYRVWLLASNALGDS 1022
T + +TGL+ Y+ +LA NA G+S
Sbjct: 17170 PETKYKVTGLRDGQTYKFRVLAVNAAGES 17198
Score = 43.5 bits (101), Expect = 0.001
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 7/105 (6%)
Query: 867 GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNAL 926
G P +W+K G +D R ++ T SS+LTI + +D +T TATN
Sbjct: 20405 GKPLPKSSWSKAG-----KDIRPSDITQITSTPTSSMLTI-KYATRKDAGEYTITATNPF 20458
Query: 927 GSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGF-DGGLP 970
G+ ++++ + P PP +++ +++ L W P DGG P
Sbjct: 20459 GTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSP 20503
Score = 43.1 bits (100), Expect = 0.002
Identities = 66/289 (22%), Positives = 104/289 (35%), Gaps = 38/289 (13%)
Query: 770 PGMFNWERLGEDEE-DQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARR 828
PG W R+ +DE Q + + G R RI A + G + + ++ +A
Sbjct: 17845 PGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD--- 17901
Query: 829 LLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLD----- 883
+ P+VE V + L R +G P TWTK G L
Sbjct: 17902 -----ILHPPEVELDVTCRDVITVRVGQTIRIL-ARVKGRPEPDITWTKEGKVLVREKRV 17955
Query: 884 --LQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941
+QD E L I A D+ + +A N+ G Q + + + RP
Sbjct: 17956 DLIQDLPRVE------------LQIKEAVRA-DHGKYIISAKNSSGHAQGSAIVNVLDRP 18002
Query: 942 DPPSGLKVVSLTPHSVGLEWKPGFDGGLPQ--RFCIRYEALGTPGFHYVDVVPPQATTFT 999
P LKV ++T + + W+ D G + F + Y G+ +V T
Sbjct: 18003 GPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGW---SIVASDVTKRL 18059
Query: 1000 L-TGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPED 1047
+ L + Y + A N +G + T+ PI GEPE+
Sbjct: 18060 IKANLLANNEYYFRVCAENKVGVGPTIE--TKTPILAINPIDRPGEPEN 18106
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 14/135 (10%)
Query: 837 APQVEHPTPLTK--VAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTY 894
AP+++ + L K V AG SA +H +G P TW++ ++ +T+
Sbjct: 24021 APELDLDSELRKGIVVRAG---GSARIHIPFKGRPTPEITWSR-------EEGEFTDKVQ 24070
Query: 895 HQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTP 954
+ GV+ + L+I N D + N+ GS + + + P PP L V +
Sbjct: 24071 IEKGVNYTQLSIDNCDR-NDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRK 24129
Query: 955 HSVGLEWKPG-FDGG 968
S L W+P DGG
Sbjct: 24130 DSAFLVWEPPIIDGG 24144
Score = 43.1 bits (100), Expect = 0.002
Identities = 44/184 (23%), Positives = 71/184 (38%), Gaps = 12/184 (6%)
Query: 864 RARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTAT 923
R + +P++V W+K+G L+ R + + + L + + D + +
Sbjct: 24732 RGKPIPDVV--WSKDGKELEETAARMEI----KSTIQKTTLVVKDCIRT-DGGQYILKLS 24784
Query: 924 NALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGT 982
N G+ I + + RP PP G LKV +T L W P G E T
Sbjct: 24785 NVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRET 24844
Query: 983 PGFHYVDV-VPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQP 1041
+ V QA + +T L P Y ++A N G + G P+T ++P
Sbjct: 24845 SRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESG---PVTACNPYKP 24901
Query: 1042 SGEP 1045
G P
Sbjct: 24902 PGPP 24905
Score = 42.4 bits (98), Expect = 0.003
Identities = 57/262 (21%), Positives = 96/262 (36%), Gaps = 33/262 (12%)
Query: 827 RRLLRLVVRFAPQVEHPTPLTKVAA----------------AGDSTSSATLHCRARGVPN 870
R + R V +P E P+T +A + ++ L G P
Sbjct: 19265 RAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPM 19324
Query: 871 IVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQ 930
+W K+G L P Q + + L N + DY T TA N+ GS
Sbjct: 19325 PTVSWKKDGT---LLKPAEGIKMAMQRNLCTLELFSVNRKDSGDY---TITAENSSGSKS 19378
Query: 931 TNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQ--RFCIRYEALGTPGFHYV 988
I+L + +P PP+ +K+ + L W+P + G + + + P + V
Sbjct: 19379 ATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQV 19438
Query: 989 DVVPPQATTFTLTGLQPSTRYRVWLLASN--ALGDSGLADKG-TQLPITTPGLHQP---S 1042
P T+ ++ L Y+ + A N +GD + + P PG P S
Sbjct: 19439 SATVP-ITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVIS 19497
Query: 1043 GEPEDQLPT--EPPSGPSGLPL 1062
+D + +PP+ G P+
Sbjct: 19498 NITKDHMTVSWKPPADDGGSPI 19519
Score = 42.0 bits (97), Expect = 0.004
Identities = 39/142 (27%), Positives = 60/142 (42%), Gaps = 4/142 (2%)
Query: 904 LTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKP 963
L + NV+ D +T T N+ G+ + + + P PP LKV +T SV + W+P
Sbjct: 22998 LVLDNVNR-YDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEP 23056
Query: 964 G-FDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDS 1022
DGG + I + T + V ++ + LQ Y + A N G
Sbjct: 23057 PLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYG-I 23115
Query: 1023 GLADKGTQLPITTPGLHQPSGE 1044
GL + T PI + QP G+
Sbjct: 23116 GLPAQ-TADPIKVAEVPQPPGK 23136
Score = 41.6 bits (96), Expect = 0.005
Identities = 44/182 (24%), Positives = 74/182 (40%), Gaps = 19/182 (10%)
Query: 898 GVHSSLLTIANVSAAQDYALFTCTATNALGSDQTN------IQLVSISRPDPPSGLKVVS 951
GV ++ + + Q+Y+ F A N G + + + + P PP L+V++
Sbjct: 14036 GVPTTQHLLPGLMEGQEYS-FRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVIN 14094
Query: 952 LTPHSVGLEWK-PGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRY 1009
+T ++ L+W P DGG P + + + G+ VD + T T+T L + Y
Sbjct: 14095 ITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTT-VKDTKCTVTPLTEGSLY 14153
Query: 1010 RVWLLASNALGDSGLADKGTQL----PITTPGLHQPSG-----EPEDQLPTEPPSGPSGL 1060
+ A NA+G S + + TTPG + L EPP G
Sbjct: 14154 VFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGR 14213
Query: 1061 PL 1062
P+
Sbjct: 14214 PI 14215
Score = 41.2 bits (95), Expect = 0.006
Identities = 43/184 (23%), Positives = 71/184 (38%), Gaps = 13/184 (7%)
Query: 866 RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNA 925
+GVP TW K D P G S L I N +A +D +++ T N
Sbjct: 17243 KGVPFPKVTWKKE----DRDAPTKARIDVTPVG---SKLEIRN-AAHEDGGIYSLTVENP 17294
Query: 926 LGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFD--GGLPQRFCIRYEALGTP 983
GS +++++ + +P PP L+V + S L WK D G + + + + +
Sbjct: 17295 AGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASA 17354
Query: 984 GFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSG 1043
+ + + + F L +Y + A N G + T PI P G
Sbjct: 17355 QWSPLSATSKKKSHFA-KHLNEGNQYLFRVAAENQYGRGPFVE--TPKPIKALDPLHPPG 17411
Query: 1044 EPED 1047
P+D
Sbjct: 17412 PPKD 17415
Score = 41.2 bits (95), Expect = 0.006
Identities = 63/254 (24%), Positives = 91/254 (35%), Gaps = 33/254 (12%)
Query: 817 IVDNGVAPPARRL-LRLVVR-FAPQVEHPTPL--TKVAAAGDSTSSATLHCRARGVPNIV 872
I D GV PA + +V R AP E L T V AG S + +G P
Sbjct: 20751 INDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAG---LSIRIFVPIKGRPAPE 20807
Query: 873 FTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTN 932
TWTK+ + +L++ E+T S L I D F T N G
Sbjct: 20808 VTWTKDNI--NLKNRANIENT------ESFTLLIIPECNRYDTGKFVMTIENPAGKKSGF 20859
Query: 933 IQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLPQRFCIRYEALGTPGFHYVDVV 991
+ + + P P L+ +T SV L W P DGG I + T +
Sbjct: 20860 VNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATT 20919
Query: 992 PPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPT 1051
T+ +TGL Y ++A N G+ +P+ E +
Sbjct: 20920 KCHKCTYKVTGLSEGCEYFFRVMAENEY-----------------GIGEPTETTEPVKAS 20962
Query: 1052 EPPSGPSGLPLLPV 1065
E PS P L ++ +
Sbjct: 20963 EAPSPPDSLNIMDI 20976
Score = 41.2 bits (95), Expect = 0.006
Identities = 34/120 (28%), Positives = 50/120 (41%), Gaps = 2/120 (1%)
Query: 902 SLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEW 961
+LL + NV+ D + T N+ GS + + + P PP LKV +T SV L W
Sbjct: 21914 TLLIVGNVNRF-DSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW 21972
Query: 962 KPG-FDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG 1020
P DGG + I + T + T++ + LQ Y +LA N G
Sbjct: 21973 DPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYG 22032
Score = 41.2 bits (95), Expect = 0.006
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 938 ISRPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQA 995
++ P PP+ +KV + +V LEW KP FDGG+ + I +H V+
Sbjct: 28251 VNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVK 28310
Query: 996 TTFTLTGLQPSTRYRVWLLASNALG 1020
T +T+T LQ Y+ + A N G
Sbjct: 28311 TRYTVTDLQAGEEYKFRVSAINGAG 28335
Score = 41.2 bits (95), Expect = 0.006
Identities = 60/304 (19%), Positives = 118/304 (38%), Gaps = 40/304 (13%)
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTF 509
P Q + G V C I G P P + W+K++ ++ S SR ++ S+E ++
Sbjct: 33140 PRSQNINEGQNVLFTC-EISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASV 33198
Query: 510 SRELVLVTGPSDNQAKFTCKA----GQLSASTQL----AVQFPPTNVTILANASALRPGD 561
S + K+T KA GQ SA+ L V+ P V + + G
Sbjct: 33199 S-----------DSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGS 33247
Query: 562 ALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRV 621
S+ V +S K+ ++ + + A+ S S ++ +
Sbjct: 33248 ---------FSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEM 33298
Query: 622 TCR-----AHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEAL-LPVSVSANPA 675
+ ++ +L + S + + P + E + ++++G+ L + + + P
Sbjct: 33299 SSSSFMGISNMTQLESSTSKMLKAGIRGIPPKI-EALPSDISIDEGKVLTVACAFTGEPT 33357
Query: 676 PEAFNWTFRGYRLSPAGGPRHRILSSG---ALHLWNVTRADDGLYQLHCQNSEGTAEARL 732
PE W+ G ++ R I ++ L + +V + D GLY L N G+ A +
Sbjct: 33358 PEV-TWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATV 33416
Query: 733 RLDV 736
+ +
Sbjct: 33417 NIHI 33420
Score = 40.4 bits (93), Expect = 0.011
Identities = 42/167 (25%), Positives = 74/167 (44%), Gaps = 42/167 (25%)
Query: 446 IEGPPE------------GQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQE 493
+E PPE G+ +R G + + +PEP + WYK + + P +
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITV-------HPEPHVTWYKSGQKIK----PGD 31734
Query: 494 SRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQF--PPTN 547
+ + + +K +L + + +D+ A++T K G+ S +L V PPT+
Sbjct: 31735 NDKKYTFESDKG----LYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTD 31790
Query: 548 VTI-------LANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL 587
T+ LANA + G ++ + VS PP L W+K+G+ L
Sbjct: 31791 STLRPMFKRLLANAEC-QEGQSVCFE-IRVSGIPPPTLKWEKDGQPL 31835
Score = 40.0 bits (92), Expect = 0.014
Identities = 36/127 (28%), Positives = 55/127 (43%), Gaps = 11/127 (8%)
Query: 19 EGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIP 78
+ +A+L I P F E+ TV E C +S + V+W ++G I
Sbjct: 12811 KSVAELLI-IEAPTEFVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGR------EIK 12863
Query: 79 GFPRYRLEGDPARGEFH-LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKL 137
+Y+ E D G H L I+ C L D+ EY C V + L + + I+ PP+
Sbjct: 12864 EGKKYKFEKD---GSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQD 12920
Query: 138 LLLTPEA 144
+L P A
Sbjct: 12921 ILEAPGA 12927
Score = 40.0 bits (92), Expect = 0.014
Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 6/127 (4%)
Query: 899 VHSSLLTIANVSAAQDYALFTCTATNALG---SDQTNIQLVSISRPDPPSGLKVVSLTPH 955
+ ++ + +SA Y F A NA G + +++I +PP +++ ++ +
Sbjct: 26724 IRTTHFKVTTISAGLIYE-FRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKN 26782
Query: 956 SVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWL 1013
SV L W +P FDGG + + L + T F ++GL +++Y +
Sbjct: 26783 SVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRV 26842
Query: 1014 LASNALG 1020
A NA+G
Sbjct: 26843 FARNAVG 26849
Score = 39.7 bits (91), Expect = 0.018
Identities = 49/197 (24%), Positives = 72/197 (36%), Gaps = 33/197 (16%)
Query: 866 RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH----SSLLTIANVSAAQDYALFTCT 921
RG P TW K G+ ++ +G V + L I N S D ++ T
Sbjct: 18631 RGRPAPKVTWRKVGI----------DNVVRKGQVDLVDTMAFLVIPN-STRDDSGKYSLT 18679
Query: 922 ATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALG 981
N G + + + P P S LKV +T S + W P + G Q E
Sbjct: 18680 LVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKRE 18739
Query: 982 TPGFHYVDVVPP-QATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQ 1040
+ V P + T+F +T L P Y + A N G PG+
Sbjct: 18740 ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYG---------------PGV-- 18782
Query: 1041 PSGEPEDQLPTEPPSGP 1057
P+ P+ L ++P S P
Sbjct: 18783 PTDVPKPVLASDPLSEP 18799
Score = 39.7 bits (91), Expect = 0.018
Identities = 26/88 (29%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 937 SISRPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLPQRFCIRYEALGTPGFHYVDVVPP-- 993
++ +P PP +V+ + S+ + W KP +DGG + AL + V PP
Sbjct: 21752 TVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQI-VTPPAG 21810
Query: 994 -QATTFTLTGLQPSTRYRVWLLASNALG 1020
+AT++T+TGL + Y++ + A N+ G
Sbjct: 21811 LKATSYTITGLTENQEYKIRIYAMNSEG 21838
Score = 39.3 bits (90), Expect = 0.024
Identities = 37/127 (29%), Positives = 58/127 (45%), Gaps = 10/127 (7%)
Query: 918 FTCTATNALG----SDQTNIQLVS--ISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLP 970
F A NA G S+ ++ ++ I P PPS +V T S+ L WK P DGG P
Sbjct: 15676 FRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSP 15735
Query: 971 -QRFCIRYEALGTPGFHYVDVVPPQATT--FTLTGLQPSTRYRVWLLASNALGDSGLADK 1027
+ + + + GT + V+ TT + L+ +YR + A N G+S +D
Sbjct: 15736 IKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDT 15795
Query: 1028 GTQLPIT 1034
++P T
Sbjct: 15796 TGEIPAT 15802
Score = 38.9 bits (89), Expect = 0.031
Identities = 30/96 (31%), Positives = 39/96 (40%), Gaps = 18/96 (18%)
Query: 938 ISRPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQA- 995
I P PP+ +VV T HS+ L W KP +DGG P I Y P D P +
Sbjct: 18494 IEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP---IIGYVVEMRP--KIADASPDEGW 18548
Query: 996 -----------TTFTLTGLQPSTRYRVWLLASNALG 1020
FT+T L + Y + A N +G
Sbjct: 18549 KRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 18584
Score = 38.5 bits (88), Expect = 0.040
Identities = 38/126 (30%), Positives = 55/126 (43%), Gaps = 9/126 (7%)
Query: 905 TIANVSAAQDYALFTCTATNALG----SDQTNIQLVS--ISRPDPPSGLKVVSLTPHSVG 958
T+ +V Q+Y+ F A N +G S T V+ I RP PP L T SV
Sbjct: 13251 TVTDVVEGQEYS-FRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQ 13309
Query: 959 LEWKPGF-DGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLAS 1016
L+W+P DGG P + I G + ++ T+ +TGL+ +Y + A
Sbjct: 13310 LKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAE 13369
Query: 1017 NALGDS 1022
N G S
Sbjct: 13370 NKAGVS 13375
Score = 38.5 bits (88), Expect = 0.040
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 8/111 (7%)
Query: 918 FTCTATNALGSD---QTNIQLV---SISRPDPPSGLKVVSLTPHSVGLEWKPG-FDGGLP 970
F A N++G +T+ LV I+ P+ P L+V +T ++V L W P +DGG
Sbjct: 16688 FRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSE 16747
Query: 971 Q-RFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG 1020
+ + +GT FH V + +T+ GL+ Y + A N +G
Sbjct: 16748 IINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVG 16798
Score = 38.5 bits (88), Expect = 0.040
Identities = 36/139 (25%), Positives = 51/139 (36%), Gaps = 2/139 (1%)
Query: 910 SAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWKPGFDGG 968
S +D +T TATN G + + + RP PP G L V +T L W P D G
Sbjct: 21524 STRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDG 21583
Query: 969 LPQRFCIRYEALGTPGFHYVDVVPP-QATTFTLTGLQPSTRYRVWLLASNALGDSGLADK 1027
+ + T + +V Q T +T L Y ++A N G +
Sbjct: 21584 GAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLES 21643
Query: 1028 GTQLPITTPGLHQPSGEPE 1046
L + G P PE
Sbjct: 21644 EPVLAVNPYGPPDPPKNPE 21662
Score = 38.5 bits (88), Expect = 0.040
Identities = 50/203 (24%), Positives = 74/203 (36%), Gaps = 12/203 (5%)
Query: 838 PQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTK-NGVPLDLQDPRYTEHTYHQ 896
P++E L KV S ++ L +G P W K G+ D T
Sbjct: 25105 PEIELDADLRKVVVLRAS-ATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSF--- 25160
Query: 897 GGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
++L I NV+ D + T N GS + + + P P L + + S
Sbjct: 25161 -----TMLVIDNVTRF-DSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDS 25214
Query: 957 VGLEWKPGF-DGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLA 1015
V L W+P DGG I + T + TTF + LQ Y +LA
Sbjct: 25215 VTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLA 25274
Query: 1016 SNALGDSGLADKGTQLPITTPGL 1038
SN G A+ + ++ P L
Sbjct: 25275 SNEYGIGLPAETTEPVKVSEPPL 25297
Score = 38.1 bits (87), Expect = 0.053
Identities = 30/108 (27%), Positives = 47/108 (43%), Gaps = 6/108 (5%)
Query: 918 FTCTATNALG----SDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGF-DGGLPQR 972
F A N+ G SD + L ++S DPP + +T ++ L+W P DGG
Sbjct: 27829 FRVYAENSAGLSSPSDPSKFTL-AVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIV 27887
Query: 973 FCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALG 1020
+ G + + +T+TGL P RY ++A NA+G
Sbjct: 27888 GYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVG 27935
Score = 38.1 bits (87), Expect = 0.053
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Query: 242 PPVIEW-PGLDEGHV-RAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVAR 299
PP++E+ P +G + ++G+SL + + +G P+ + W K+G + E T +
Sbjct: 27955 PPIVEFGPEYFDGLIIKSGESLRIKALVQG-RPVPRVTWFKDGVEIEKRMNMEITDVLGS 28013
Query: 300 SVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVT 337
+ L + DH + EA N+ + E + +Q T
Sbjct: 28014 TSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDT 28051
Score = 38.1 bits (87), Expect = 0.053
Identities = 31/130 (23%), Positives = 57/130 (43%), Gaps = 9/130 (6%)
Query: 899 VHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSI------SRPDPPSGLKVVSL 952
+ +++ T+ + +Y F A N +G +T+ + +P P L+++S+
Sbjct: 30384 ITTTMYTVTGLVPDAEYQ-FRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSI 30442
Query: 953 TPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYR 1010
+ SV L+W KP DGG + + Y G + + + FT+ GL +T Y
Sbjct: 30443 SKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYE 30502
Query: 1011 VWLLASNALG 1020
+ A N G
Sbjct: 30503 FRVFAENETG 30512
Score = 37.7 bits (86), Expect = 0.069
Identities = 34/127 (26%), Positives = 50/127 (39%), Gaps = 19/127 (14%)
Query: 34 FWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGE 93
F + P+NL ++EG E C +S VQW +D D + +Y + D +
Sbjct: 12554 FISKPQNLEILEGEKAEFVCSISKESFPVQWKRD------DKTLESGDKYDVIADGKKRV 12607
Query: 94 FHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAG 153
L ++ L D Y VG + R + V KL ++ P T V
Sbjct: 12608 --LVVKDATLQDMGTYVVMVG---------AARAAAHLTVIEKLRIVVPLKDTRVK--EQ 12654
Query: 154 QEYVVNC 160
QE V NC
Sbjct: 12655 QEVVFNC 12661
Score = 37.7 bits (86), Expect = 0.069
Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 11/112 (9%)
Query: 941 PDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTF 998
P PP+ L+ +T +V L W +P DGG P + + T + + +P + TT+
Sbjct: 13883 PGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTY 13942
Query: 999 TLTGLQPSTRYRVWLLASNALGDSGLADKGTQL-----PITTPGLHQPSGEP 1045
+ GL +YR +LA N G G K T+ PI P P G+P
Sbjct: 13943 RVKGLTNKKKYRFRVLAENLAG-PGKPSKSTEPILIKDPIDPP---WPPGKP 13990
Score = 37.7 bits (86), Expect = 0.069
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 9/76 (11%)
Query: 516 VTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPP 575
++ PS+ TC+ + ++ V+F T + L+ G+A L VS PP
Sbjct: 21440 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVI--------LKAGEAFRLEA-DVSGRPP 21490
Query: 576 VNLSWDKEGERLEGVA 591
+ W K+G+ LEG A
Sbjct: 21491 PTMEWSKDGKELEGTA 21506
Score = 37.7 bits (86), Expect = 0.069
Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Query: 942 DPPSGLKVVSLTPHSVGLEWK-PGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFT 999
DPP + + +T ++V L+WK P +DGG + + + L + T FT
Sbjct: 24604 DPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFT 24663
Query: 1000 LTGLQPSTRYRVWLLASNALGD 1021
++GL RY ++A NA G+
Sbjct: 24664 VSGLVEDQRYEFRVIARNAAGN 24685
Score = 37.4 bits (85), Expect = 0.090
Identities = 32/105 (30%), Positives = 45/105 (42%), Gaps = 3/105 (2%)
Query: 918 FTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLPQRFCIR 976
++ TA N G N ++ + P PP LKV +T S L WK P DGG + +
Sbjct: 15889 YSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYV- 15947
Query: 977 YEALGTPGFHYVDVVPP-QATTFTLTGLQPSTRYRVWLLASNALG 1020
E G + V P +TTF + L +Y + A N G
Sbjct: 15948 IEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFG 15992
Score = 37.4 bits (85), Expect = 0.090
Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 8/104 (7%)
Query: 867 GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNAL 926
G P V +W K+G+ ++++ TE + +LLT+ + +D + T N
Sbjct: 25815 GRPLPVISWAKDGI--EIEERARTEIISTD---NHTLLTVKDC-IRRDTGQYVLTLKNVA 25868
Query: 927 GSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEW-KPGFDGG 968
G+ + + +P PP+G L++ LT L W +P DGG
Sbjct: 25869 GTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGG 25912
Score = 37.4 bits (85), Expect = 0.090
Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 6/84 (7%)
Query: 940 RPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLPQRFCIRY--EALGTPGFHYVDVVPPQAT 996
+P PP L V S++ SV L W KP DGG + Y EAL ++V ++T
Sbjct: 26374 KPSPPEKLGVTSISKDSVSLTWLKPEHDGG---SRIVHYVVEALEKGQKNWVKCAVAKST 26430
Query: 997 TFTLTGLQPSTRYRVWLLASNALG 1020
++GL+ ++ Y + A N G
Sbjct: 26431 HHVVSGLRENSEYFFRVFAENQAG 26454
Score = 37.0 bits (84), Expect = 0.12
Identities = 38/135 (28%), Positives = 57/135 (42%), Gaps = 14/135 (10%)
Query: 901 SSLLTIANVSAAQDYALFTCTATN--ALGSDQTNIQLVS----ISRPDPPSGLKVVSLTP 954
S+ + ++ + Q Y F A N +G IQ + I PDPP LK+ +T
Sbjct: 15967 STTFVVPDLLSEQQY-FFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITK 16025
Query: 955 HSVGLEWK-PGFDGGLPQRF----CIRYEALGT--PGFHYVDVVPPQATTFTLTGLQPST 1007
++V L WK P DGG P C+ ++ GT + + + FT+ L
Sbjct: 16026 NTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGG 16085
Query: 1008 RYRVWLLASNALGDS 1022
Y + A NA G S
Sbjct: 16086 EYEFRVKAVNAAGVS 16100
Score = 37.0 bits (84), Expect = 0.12
Identities = 33/95 (34%), Positives = 42/95 (44%), Gaps = 7/95 (7%)
Query: 941 PDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTF 998
P PP L V + V L W KP DGG P + + Y+ GT + V
Sbjct: 17410 PGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECV- 17468
Query: 999 TLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPI 1033
+TGLQ YR + A N +G GL D T +PI
Sbjct: 17469 -VTGLQQGKTYRFRVKAENIVG-LGLPD--TTIPI 17499
Score = 36.6 bits (83), Expect = 0.15
Identities = 53/262 (20%), Positives = 93/262 (35%), Gaps = 36/262 (13%)
Query: 801 LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSAT 860
L I +AK G Y I+DN V R+ V P+T + S
Sbjct: 27621 LSIKNAKKEHGGKYTVILDNAVC-------RIAV----------PITVITLGPPSKPKGP 27663
Query: 861 LHCRARGVPNIVFTW---TKNG------VPLDLQDPRYTEHTYHQGGVHSSLLTIANVSA 911
+ +++ +W NG ++ ++ T V + + N+
Sbjct: 27664 IRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVK 27723
Query: 912 AQDYALFTCTATNALGSDQTNIQLVSISR-----PDPPSGLKVVSLTPHSVGLEW-KPGF 965
+Y F A N G Q + + +++ P PP + ++T + L W P +
Sbjct: 27724 DAEYQ-FRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVY 27782
Query: 966 DGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGL 1024
DGG F + + + + V+ P + TGL Y+ + A N+ G S
Sbjct: 27783 DGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSP 27842
Query: 1025 ADKGTQLPITTPGLHQPSGEPE 1046
+D +P P G P+
Sbjct: 27843 SDPSKFTLAVSP--VDPPGTPD 27862
Score = 36.6 bits (83), Expect = 0.15
Identities = 34/123 (27%), Positives = 48/123 (39%), Gaps = 12/123 (9%)
Query: 847 TKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTI 906
T V AG +S L +G P W+K L L+ +T ++ S LT+
Sbjct: 28366 THVVRAG---ASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSF-------STLTV 28415
Query: 907 ANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEW-KPGF 965
N + D +T T N GS + + P PP + +T S L W P
Sbjct: 28416 ENCNR-NDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLL 28474
Query: 966 DGG 968
DGG
Sbjct: 28475 DGG 28477
Score = 36.6 bits (83), Expect = 0.15
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 8/122 (6%)
Query: 921 TATNALGSDQTN------IQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGGLPQR- 972
TA NA GS + + + + I+ P P +V T SV L W P +GG
Sbjct: 30007 TAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG 30066
Query: 973 FCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLP 1032
+ I + + + + P + +TLT L YR +LA NA G A+ +
Sbjct: 30067 YLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVK 30126
Query: 1033 IT 1034
+T
Sbjct: 30127 VT 30128
Score = 36.2 bits (82), Expect = 0.20
Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 10/160 (6%)
Query: 866 RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDY-ALFTCTATN 924
+G P +W K+G+PL E + + + +T++ +A +++ +T N
Sbjct: 27588 KGKPKPSISWLKDGLPL-------KESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDN 27640
Query: 925 ALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTP 983
A+ I ++++ P P G ++ + SV L W D G + C E T
Sbjct: 27641 AVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETS 27700
Query: 984 GFHYVDVVPPQA-TTFTLTGLQPSTRYRVWLLASNALGDS 1022
++ V A TTF + L Y+ + A N G S
Sbjct: 27701 QTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 27740
Score = 35.8 bits (81), Expect = 0.26
Identities = 36/118 (30%), Positives = 47/118 (39%), Gaps = 9/118 (7%)
Query: 852 AGDSTSSATLHCRARGVPNIVFTWTKNGVPLDL-QDPRYTEHTYHQGGVHSSLLTIANVS 910
AGD+ L RG P WTK+ DL + PR T S LT A S
Sbjct: 18215 AGDTIR---LEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS--LTKAKRS 18269
Query: 911 AAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGG 968
Y + TATN GS + + +P P LK+V ++ + W P D G
Sbjct: 18270 DGGKYVV---TATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDG 18324
Score = 35.8 bits (81), Expect = 0.26
Identities = 31/130 (23%), Positives = 55/130 (42%), Gaps = 5/130 (3%)
Query: 918 FTCTATNALGSDQTNIQ---LVSISRPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QR 972
F A N G + ++ +V++ DPP +V+++T +SV L W +P +DGG
Sbjct: 20248 FRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTG 20307
Query: 973 FCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLP 1032
+ + L + + + V FT+T L +Y + A N G + T+
Sbjct: 20308 YIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETI 20367
Query: 1033 ITTPGLHQPS 1042
I P+
Sbjct: 20368 ICKDEYEAPT 20377
Score = 35.8 bits (81), Expect = 0.26
Identities = 30/113 (26%), Positives = 45/113 (39%), Gaps = 7/113 (6%)
Query: 857 SSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
S L G P WTK LDL + ++T G ++++ + S D
Sbjct: 29063 SDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYT---GKRATAVIKFCDRS---DSG 29116
Query: 917 LFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PGFDGG 968
+T T NA G+ ++ + + P P L V +T L W P DGG
Sbjct: 29117 KYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGG 29169
Score = 35.4 bits (80), Expect = 0.34
Identities = 58/212 (27%), Positives = 79/212 (37%), Gaps = 14/212 (6%)
Query: 656 VTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGA---LHLWNVTRA 712
V +E A +S P PE +W G +S + P +I S L + VT+A
Sbjct: 15 VVVLEGSTATFEAHISGFPVPEV-SWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKA 73
Query: 713 DDGLYQLHCQNSEG--TAEARLRLDVHYAPT--IRALQDPTEVNVGGSVDIVCTVDANPI 768
+ G Y L N G T+ A L + AP ++ LQ T V G V + V P
Sbjct: 74 NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMT-VRQGSQVRLQVRVTGIPT 132
Query: 769 LPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARR 828
F + E QS D + G L I A +G Y N V A
Sbjct: 133 PVVKF----YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG-RATS 187
Query: 829 LLRLVVRFAPQVEHPTPLTKVAAAGDSTSSAT 860
L+V+ +V T V+ A S S T
Sbjct: 188 TAELLVQGEEEVPAKKTKTIVSTAQISESRQT 219
Score = 35.4 bits (80), Expect = 0.34
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 942 DPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFT 999
DPP + + +T +SV L+W KP +DGG + + + L + T F
Sbjct: 22440 DPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFE 22499
Query: 1000 LTGLQPSTRYRVWLLASNALG 1020
+TGL RY ++A NA G
Sbjct: 22500 VTGLVEDHRYEFRVIARNAAG 22520
Score = 35.0 bits (79), Expect = 0.44
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 906 IANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWK-PG 964
+ + S D ++T N + + I + I+RP P LK +T SV L W+ P
Sbjct: 13453 VISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPD 13512
Query: 965 FDGGLP 970
DGG P
Sbjct: 13513 DDGGSP 13518
Score = 35.0 bits (79), Expect = 0.44
Identities = 18/45 (40%), Positives = 26/45 (57%)
Query: 696 HRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAP 740
H+ SS L + +VTR D G Y L +NS GT ++++ V AP
Sbjct: 18948 HKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAP 18992
Score = 35.0 bits (79), Expect = 0.44
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 2/79 (2%)
Query: 942 DPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFT 999
DPP +V ++T SV L+W KP +DGG + + L + + Q T F
Sbjct: 25686 DPPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFE 25745
Query: 1000 LTGLQPSTRYRVWLLASNA 1018
+T L RY + A NA
Sbjct: 25746 VTELTEDQRYEFRVFARNA 25764
Score = 35.0 bits (79), Expect = 0.44
Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 28/185 (15%)
Query: 886 DPRYTEH---TYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISR-- 940
+ R T H T +G + + + + +Y +F T N G + ++ V+I
Sbjct: 25921 EKRETSHLAWTICEGELQMTSCKVTKLLKGNEY-IFRVTGVNKYGVGEP-LESVAIKALD 25978
Query: 941 ----PDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQ 994
P PP+ L++ S+T S+ L W +P DGG + I + + V+ P
Sbjct: 25979 PFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVY 26038
Query: 995 ATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQ--LPTE 1052
TGL+ Y + A NA G ++ P P ED LP+
Sbjct: 26039 DLRVKSTGLREGCEYEYRVYAENAAG------------LSLPSETSPLIRAEDPVFLPS- 26085
Query: 1053 PPSGP 1057
PPS P
Sbjct: 26086 PPSKP 26090
Score = 34.7 bits (78), Expect = 0.58
Identities = 29/127 (22%), Positives = 56/127 (44%), Gaps = 16/127 (12%)
Query: 468 IGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFT 527
I G P P + W++D + ++ S LP V+ S S +L + N +++
Sbjct: 29 ISGFPVPEVSWFRDGQVISTSTLP---------GVQISFSDGRAKLTIPAVTKANSGRYS 79
Query: 528 CKA----GQLSASTQLAV--QFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWD 581
KA GQ +++ +L V + P N + +R G + L V V+ P + +
Sbjct: 80 LKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ-VRVTGIPTPVVKFY 138
Query: 582 KEGERLE 588
++G ++
Sbjct: 139 RDGAEIQ 145
Score = 34.7 bits (78), Expect = 0.58
Identities = 75/320 (23%), Positives = 119/320 (37%), Gaps = 50/320 (15%)
Query: 724 SEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPI------LPGMFNWER 777
SE T E + D + APTI + DPT + G ++ T+ N I LP +W +
Sbjct: 20361 SEST-ETIICKDEYEAPTI--VLDPT-IKDGLTIKAGDTIVLNAISILGKPLPKS-SWSK 20415
Query: 778 LGEDEEDQSLDDMEKISRGPTGR-LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRF 836
G+D D+ +I+ PT L I +A AG Y N + ++ V
Sbjct: 20416 AGKDIRPS---DITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHV-KVTVLD 20471
Query: 837 APQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTK----NGVPLD--LQDPRYT 890
P P ++ V+A ATL TWT G P+ + + R T
Sbjct: 20472 VPGPPGPVEISNVSA-----EKATL------------TWTPPLEDGGSPIKSYILEKRET 20514
Query: 891 EH---TYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQT----NIQLVS-ISRPD 942
T + S + +Y +F +A N G + +++V P
Sbjct: 20515 SRLLWTVVSEDIQSCRHVATKLIQGNEY-IFRVSAVNHYGKGEPVQSEPVKMVDRFGPPG 20573
Query: 943 PPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVV--PPQATTFTL 1000
PP +V ++T ++ + WK D G + E +V + P +
Sbjct: 20574 PPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKV 20633
Query: 1001 TGLQPSTRYRVWLLASNALG 1020
TGLQ + Y + A N G
Sbjct: 20634 TGLQEGSTYEFRVSAENRAG 20653
Score = 34.7 bits (78), Expect = 0.58
Identities = 43/168 (25%), Positives = 68/168 (40%), Gaps = 48/168 (28%)
Query: 904 LTIANVSAAQDYALFTCTATNALGSDQTNIQLV------SISRPDPPSGLKVVSLTPHSV 957
L + ++ +Y F +A NA G + + V + +P PP+ +V T +S+
Sbjct: 23878 LRVTGLTEDHEYE-FRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSI 23936
Query: 958 GLEW-KPGFDGGLPQRFCIRYEALGTPGFHYV-----------DVVPPQ----ATTFTLT 1001
L W KP +DGG E LG YV +V PQ T F ++
Sbjct: 23937 TLAWGKPIYDGG--------SEILG-----YVVEICKADEEEWQIVTPQTGLRVTRFEIS 23983
Query: 1002 GLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQL 1049
L Y++ + A N +G + T +P T +PED+L
Sbjct: 23984 KLTEHQEYKIRVCALNKVG----LGEATSVPGTV--------KPEDKL 24019
Score = 34.7 bits (78), Expect = 0.58
Identities = 33/132 (25%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 838 PQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQG 897
P ++ P T+V TS L G P W K+ L E+T
Sbjct: 26870 PVIDLPLEYTEVVKYRAGTS-VKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLA 26928
Query: 898 GVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHS 956
+ L+ A+ + Y L NA+GS I++ + +P PP G ++ ++T
Sbjct: 26929 SI---LIKDADRLNSGCYEL---KLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEK 26982
Query: 957 VGLEWKPGFDGG 968
+ L W+P D G
Sbjct: 26983 ITLLWRPPADDG 26994
Score = 34.3 bits (77), Expect = 0.76
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 2/84 (2%)
Query: 941 PDPPSGLKVVSLTPHSVGLEWKPG-FDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTF 998
PDPP ++V + T ++ + WKP +DGG + I A G + + T+
Sbjct: 14580 PDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTY 14639
Query: 999 TLTGLQPSTRYRVWLLASNALGDS 1022
T GL+ Y+ + A NA G S
Sbjct: 14640 TAKGLEEGKEYQFRVRAENAAGIS 14663
Score = 34.3 bits (77), Expect = 0.76
Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 14/134 (10%)
Query: 899 VHSSLLTIANVSAAQDYALFTCTATNALGSDQTN--IQLVSISRP-DPPSGLKVVSLTPH 955
V S+ A + +Y+ F A N GS + + V+ P DPP +V+ +T
Sbjct: 19146 VRSTEYPCAGLVEGLEYS-FRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKS 19204
Query: 956 SVGLEW-KPGFDGGLPQRFCIRY--EALGTPGFHYV--DVVPPQ--ATTFTLTGLQPSTR 1008
+V L W +P DGG I Y EA PG +V + P Q +T TGL+ +
Sbjct: 19205 TVSLIWARPKHDGGSK---IIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQ 19261
Query: 1009 YRVWLLASNALGDS 1022
Y+ +A A+ S
Sbjct: 19262 YQFRAIARTAVNIS 19275
Score = 34.3 bits (77), Expect = 0.76
Identities = 29/114 (25%), Positives = 45/114 (39%), Gaps = 5/114 (4%)
Query: 248 PGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVR 307
P V+ GQ L++ V G P T+ W K+G P+ T ++ + L +
Sbjct: 23234 PAFSSYSVQVGQDLKIE-VPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKET 23292
Query: 308 PEDHGAQLSCEAHNSVSAGTQE-HGITLQVTFPPSAIIILGSASQTENKNVTLS 360
+D G Q N V T +TL PP + S +++TLS
Sbjct: 23293 HKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSA---ESITLS 23343
Score = 34.3 bits (77), Expect = 0.76
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 6/127 (4%)
Query: 899 VHSSLLTIANVSAAQDYALFTCTATNALG---SDQTNIQLVSISRPDPPSGLKVVSLTPH 955
+H + N+ +Y F A N +G + + + V+ DPP + + + +
Sbjct: 23477 IHDTQFKAQNLEEGIEYE-FRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRN 23535
Query: 956 SVGLEW-KPGFDGG-LPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWL 1013
+ L+W KP +DGG + + + L + T FT++GL RY +
Sbjct: 23536 EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 23595
Query: 1014 LASNALG 1020
+A NA G
Sbjct: 23596 IAKNAAG 23602
Score = 34.3 bits (77), Expect = 0.76
Identities = 18/49 (36%), Positives = 25/49 (51%), Gaps = 1/49 (2%)
Query: 454 KLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSV 502
K RAGT V+L I G P P++ WYKD + + + L L S+
Sbjct: 26883 KYRAGTSVKLRA-GISGKPAPTIEWYKDDKELQTNALVCVENTTDLASI 26930
Score = 33.9 bits (76), Expect = 0.99
Identities = 77/318 (24%), Positives = 107/318 (33%), Gaps = 35/318 (11%)
Query: 741 TIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGR 800
TI +P N GG + + VD L G W R E +++I G +
Sbjct: 15017 TIELEWEPPAFNGGGEI-VGYFVDKQ--LVGTNEWSRCTEKMIKVRQYTVKEIREGADYK 15073
Query: 801 LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSA- 859
LR+ A G PP V A E P V+ G A
Sbjct: 15074 LRVSAVNAA-----------GEGPPGETQ---PVTVAEPQEPPAVELDVSVKGGIQIMAG 15119
Query: 860 -TLHCRA----RGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQD 914
TL A R VP V WTK LD +D ++ G S L I + +D
Sbjct: 15120 KTLRIPAVVTGRPVPTKV--WTKEEGELD-KDRVVIDNV----GTKSEL--IIKDALRKD 15170
Query: 915 YALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFC 974
+ + TATN+ GS ++ P P LK V L W D G +
Sbjct: 15171 HGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITG 15230
Query: 975 IRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPIT 1034
E + + + + +TGL Y+ ++A N G + G L +
Sbjct: 15231 FIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVD 15290
Query: 1035 TPGLHQPSGEPEDQLPTE 1052
G P PE TE
Sbjct: 15291 PLG---PPTSPERLTYTE 15305
Score = 33.9 bits (76), Expect = 0.99
Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 8/128 (6%)
Query: 900 HSSLLTIANVSAAQDYALFTCTATNALG---SDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
H + +S +Y F A N G +T + + P PP L ++ +T +
Sbjct: 20922 HKCTYKVTGLSEGCEY-FFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKST 20980
Query: 957 VGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLL 1014
V L W KP DGG + I + G+ + ++ V + + L Y ++
Sbjct: 20981 VSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV--KGLECVVRNLTEGEEYTFQVM 21038
Query: 1015 ASNALGDS 1022
A N+ G S
Sbjct: 21039 AVNSAGRS 21046
Score = 33.9 bits (76), Expect = 0.99
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 8/72 (11%)
Query: 904 LTIANVSAAQDYALFTCTATNALGSDQTNIQLV------SISRPDPPSGLKVVSLTPHSV 957
L + + DY F +A NA G + + I +P PP+ KV+ +T SV
Sbjct: 22796 LRVTGLIENHDYE-FRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSV 22854
Query: 958 GLEW-KPGFDGG 968
L W KP +DGG
Sbjct: 22855 FLSWSKPIYDGG 22866
Score = 33.9 bits (76), Expect = 0.99
Identities = 46/228 (20%), Positives = 93/228 (40%), Gaps = 20/228 (8%)
Query: 521 DNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSW 580
D + T K + T ++ PP L N +A G+ + V+++ +P +++W
Sbjct: 31666 DYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAY-VGENVRFG-VTITVHPEPHVTW 31723
Query: 581 DKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRL 640
K G++++ ++ F+ + + + D T A + ++ + +
Sbjct: 31724 YKSGQKIKP-GDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782
Query: 641 NV-------LYRPEFLGEQVLVVTAVEQGEAL-LPVSVSANPAPEAFNWTFRGYRLSPAG 692
+ RP F +++L ++G+++ + VS P P W G LS
Sbjct: 31783 TLHPPPTDSTLRPMF--KRLLANAECQEGQSVCFEIRVSGIPPP-TLKWEKDGQPLSL-- 31837
Query: 693 GPRHRILSSG----ALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV 736
GP I+ G ALH+ + D G Y++ N+ G+ + L V
Sbjct: 31838 GPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 33.9 bits (76), Expect = 0.99
Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 7/100 (7%)
Query: 656 VTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSS---GALHLWNVTRA 712
+T E A P P W +G LS + RH++ ++ + +V +
Sbjct: 32570 MTVYEGESARFSCDTDGEPVPTV-TWLRKGQVLSTSA--RHQVTTTKYKSTFEISSVQAS 32626
Query: 713 DDGLYQLHCQNSEGTAEARLRLDVHYA-PTIRALQDPTEV 751
D+G Y + +NSEG EA L + A T +A+ P V
Sbjct: 32627 DEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRV 32666
Score = 33.5 bits (75), Expect = 1.3
Identities = 27/90 (30%), Positives = 39/90 (43%), Gaps = 7/90 (7%)
Query: 857 SSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
S + RA G PN W KN D+ P +G + L I + + +QD A
Sbjct: 1571 SRLEMKVRATGNPNPDIVWLKNS---DIIVPHKYPKIRIEGTKGEAALKIDS-TVSQDSA 1626
Query: 917 LFTCTATNALGSDQTNIQL---VSISRPDP 943
+T TA N G D T ++ V + P+P
Sbjct: 1627 WYTATAINKAGRDTTRCKVNVEVEFAEPEP 1656
Score = 33.5 bits (75), Expect = 1.3
Identities = 109/540 (20%), Positives = 181/540 (33%), Gaps = 64/540 (11%)
Query: 351 QTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPME--ETVMDGLHGGHISMSNLTFLARR 408
QT + T + SR ++W+ ++L + E V DG + L
Sbjct: 12294 QTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADG------RVRKLVIHDCT 12347
Query: 409 EDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAI 468
++ T TC+A + FK S LNV P + P ++R R C
Sbjct: 12348 PEDIKTYTCDA-------KDFKTSCNLNVVPPHVEFL--RPLTDLQVREKEMARFECELS 12398
Query: 469 GGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC 528
N + + W+KD + + + + + G+V R LV+ D++A+++C
Sbjct: 12399 RENAK--VKWFKDGAEIKKGK---KYDIISKGAV--------RILVINKCLLDDEAEYSC 12445
Query: 529 KAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLE 588
+ S L V N + + + + V S P + W K E +
Sbjct: 12446 EVRTARTSGMLTVL--EEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEII 12503
Query: 589 GVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEF 648
R R +++Q + + CR S+ V +++ L
Sbjct: 12504 ETG----RYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKV----KVHELAAEFI 12555
Query: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSG---ALH 705
Q L + E+ E + +S + P W L G ++ +++ G L
Sbjct: 12556 SKPQNLEILEGEKAEFVCSISKESFPV----QWKRDDKTLE--SGDKYDVIADGKKRVLV 12609
Query: 706 LWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDA 765
+ + T D G Y + G A A L V I T V V C V+
Sbjct: 12610 VKDATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNT 12665
Query: 766 NPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPP 825
F E D + + + LRI A L Y + N
Sbjct: 12666 EGAKAKWFRNEEAIFDSSKYII-----LQKDLVYTLRIRDAHLDDQANYNVSLTNHRGEN 12720
Query: 826 ARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNG--VPLD 883
+ L+V + PL + S T C+ + N+ WTKNG VP D
Sbjct: 12721 VKSAANLIVE-EEDLRIVEPLKDIETM--EKKSVTFWCKVNRL-NVTLKWTKNGEEVPFD 12776
Score = 33.1 bits (74), Expect = 1.7
Identities = 32/107 (29%), Positives = 46/107 (42%), Gaps = 13/107 (12%)
Query: 835 RFAPQVEHP-TPLTKVAAAGDST----SSATLHCRARGVPNIVFTWTKNGVPLDLQ-DPR 888
R VE P TP T V+ + T S TL C G P+ TW + ++ D +
Sbjct: 931 RVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ 990
Query: 889 YTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
T Q G+ ++ A A+D FTC+A N G+ T+ L
Sbjct: 991 IT----FQSGIARLMIREA---FAEDSGRFTCSAVNEAGTVSTSCYL 1030
Score = 33.1 bits (74), Expect = 1.7
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 9/80 (11%)
Query: 39 ENLTVVEGASVELRCGVSTPG-SAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLH 97
+++ V+EG L C VS P ++V+W + + PD R+ ++G R L
Sbjct: 2452 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAI----VKGTKQR----LV 2503
Query: 98 IEACDLSDDAEYECQVGRSE 117
I SD+ Y+ VGR E
Sbjct: 2504 INRTHASDEGPYKLIVGRVE 2523
Score = 33.1 bits (74), Expect = 1.7
Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 21/131 (16%)
Query: 40 NLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFH-LHI 98
+L V E C +S + V+W KDG I +Y + ++G L I
Sbjct: 12382 DLQVREKEMARFECELSRENAKVKWFKDGA------EIKKGKKYDII---SKGAVRILVI 12432
Query: 99 EACDLSDDAEYECQVGRSE-------MGPELVSPRVILSILVPP----KLLLLTPEAGTM 147
C L D+AEY C+V + + E V + + +I V KL+ + G
Sbjct: 12433 NKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAE 12492
Query: 148 VTWVAGQEYVV 158
V W G E ++
Sbjct: 12493 VIWYKGDEEII 12503
Score = 33.1 bits (74), Expect = 1.7
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 4/85 (4%)
Query: 940 RPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVPPQATT 997
RP PP + ++ +T +SV L W KP DGG + + + G+ + + T
Sbjct: 22048 RPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSD--KWATCATVKVTE 22105
Query: 998 FTLTGLQPSTRYRVWLLASNALGDS 1022
T+TGL Y + A N G S
Sbjct: 22106 ATITGLIQGEEYSFRVSAQNEKGIS 22130
Score = 33.1 bits (74), Expect = 1.7
Identities = 46/210 (21%), Positives = 82/210 (39%), Gaps = 32/210 (15%)
Query: 158 VNCVSGDAKPAPDITILLSGQTISDISANV-------NEGSQQKLFTVEATARVTPRSSD 210
V+ V P+P + L+ +S SA++ + GS+ + VE + T + S
Sbjct: 24204 VDAVKAAEPPSPPGKVTLTD--VSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSI 24261
Query: 211 NRQLLVCEASSPALEAPIKASFTVNVLFPPG---PPVIEWPGLDEG-------------- 253
+ VC A L + + F V G P V+ P + +
Sbjct: 24262 VAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTY 24321
Query: 254 HVRAGQSL--ELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDH 311
++AG+ L E+P + G P + W+K+G+P+ + +VL + +D
Sbjct: 24322 SIQAGEDLKIEIPVI---GRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDD 24378
Query: 312 GAQLSCEAHNSVSAGTQEHG-ITLQVTFPP 340
+ + A NS T+ I L+ PP
Sbjct: 24379 FGKYTVTATNSAGTATENLSVIVLEKPGPP 24408
Score = 33.1 bits (74), Expect = 1.7
Identities = 45/177 (25%), Positives = 65/177 (36%), Gaps = 28/177 (15%)
Query: 167 PAPDITILLSGQTISDISANVNEGSQQKLFTVEATA-----RVTPRSSDNRQLLVCEASS 221
P P +T SGQ I G K +T E+ + ++D+ A +
Sbjct: 31717 PEPHVTWYKSGQKIKP-------GDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARN 31769
Query: 222 PALEAPIKASFTVNVLFPPGPPVIEWPG---LDEGHVRAGQSLELPCVARGGNPLATLQW 278
E KA TV + PP + L + GQS+ + G P TL+W
Sbjct: 31770 KYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFE-IRVSGIPPPTLKW 31828
Query: 279 LKNGQPVSTAWGTE--HTQAVARSVLVMTVRPEDHG----------AQLSCEAHNSV 323
K+GQP+S E H ++ + PED G SC+AH V
Sbjct: 31829 EKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 32.7 bits (73), Expect = 2.2
Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 901 SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPS-GLKVVSLTPHSVGL 959
SS+L I +V+ +D ++ TA N+ G+D I++V + P PP + + + L
Sbjct: 18953 SSILIIKDVTR-KDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSL 19011
Query: 960 EWK-PGFDGG 968
W P DGG
Sbjct: 19012 SWHIPLEDGG 19021
Score = 32.7 bits (73), Expect = 2.2
Identities = 24/106 (22%), Positives = 45/106 (42%), Gaps = 2/106 (1%)
Query: 242 PPVIEWPGLDEG-HVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
P ++ P + +G ++AG ++ L ++ G PL W K G+ + + T+ T S
Sbjct: 20376 PTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSS 20435
Query: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT-LQVTFPPSAIII 345
+L + + + A N + +T L V PP + I
Sbjct: 20436 MLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEI 20481
Score = 32.7 bits (73), Expect = 2.2
Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 3/83 (3%)
Query: 941 PDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGF-HYVDVVPPQATT 997
P PPS V T S L W KP +DGGL + + ++ +G + + T
Sbjct: 20673 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 20732
Query: 998 FTLTGLQPSTRYRVWLLASNALG 1020
F + LQ +Y + A N G
Sbjct: 20733 FVVPDLQTKEKYNFRISAINDAG 20755
Score = 32.7 bits (73), Expect = 2.2
Identities = 27/90 (30%), Positives = 39/90 (43%), Gaps = 4/90 (4%)
Query: 935 LVSISRPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVP 992
+V+ +P PP L VV + S L W KP DGG + + G+ +V+
Sbjct: 28540 IVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSD--FWVEAGH 28597
Query: 993 PQATTFTLTGLQPSTRYRVWLLASNALGDS 1022
+ TFT+ L T Y + A N G S
Sbjct: 28598 TKQLTFTVERLVEKTEYEFRVKAKNDAGYS 28627
Score = 32.7 bits (73), Expect = 2.2
Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 11/95 (11%)
Query: 255 VRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVL-VMTVRPEDHGA 313
V G+S C G P+ T+ WL+ GQ +ST+ + T +S + +V+ D G
Sbjct: 32572 VYEGESARFSCDT-DGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEG- 32629
Query: 314 QLSCEAHNSVSAGTQEHGITLQ--------VTFPP 340
S NS E +T+Q VT PP
Sbjct: 32630 NYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP 32664
Score = 32.3 bits (72), Expect = 2.9
Identities = 87/448 (19%), Positives = 162/448 (36%), Gaps = 77/448 (17%)
Query: 502 VEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQL-----AVQFPPTNVTILANASA 556
+E G + +L ++ D++ K+T AG+ S +L A+ P T+ T+ + A
Sbjct: 2580 IEAHGKIY--KLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQTVAESQEA 2637
Query: 557 LRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRD 616
+ + +NP W ++G+ L + R +++ + D
Sbjct: 2638 VFECEV---------ANPDSKGEWLRDGKHLPLT----NNIRSESDGHKRRLIIAATKLD 2684
Query: 617 ----HGQRVTCRAHSAELR-ETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVS 671
+ +V SA+L+ E V L L T E +A+ V ++
Sbjct: 2685 DIGEYTYKVATSKTSAKLKVEAVKIKKTLKNL-------------TVTETQDAVFTVELT 2731
Query: 672 ANPAPEAFNWTFRGYRLSPAGGPRHRILSSG---ALHLWNVTRADDGLYQLHCQNSEGTA 728
+P + W G L ++ I G +L + N D+ +Y G
Sbjct: 2732 -HPNVKGVQWIKNGVVLE--SNEKYAISVKGTIYSLRIKNCAIVDESVYGFRL----GRL 2784
Query: 729 EARLRLDVHYAPTIRALQDPTEV-NVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSL 787
A RL V I+ +D T + N + ++ + D P+ W + E +
Sbjct: 2785 GASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPV-----KW--FHKSVEIKPS 2837
Query: 788 DDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLT 847
D +S +L + + + AG Y +V L + + H T
Sbjct: 2838 DKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQ---------LECKAKLFVETLHITKTM 2888
Query: 848 KVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIA 907
K + T +A+ C N+ W KNGV +++ + QG +H ++
Sbjct: 2889 KNIEVPE-TKTASFECEVSHF-NVPSMWLKNGVEIEMSE---KFKIVVQGKLHQLIIMNT 2943
Query: 908 NVSAAQDYALFTCTATNALGSDQTNIQL 935
+ + +Y F C G+DQ + L
Sbjct: 2944 STEDSAEYT-FVC------GNDQVSATL 2964
Score = 32.3 bits (72), Expect = 2.9
Identities = 36/144 (25%), Positives = 58/144 (40%), Gaps = 21/144 (14%)
Query: 383 PMEETVMD--GLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYP 440
P+ ET M+ GL G + L R+ + + E T+E + L+VK
Sbjct: 13640 PVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEA--PEIFLDVKLL 13697
Query: 441 AQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMW------YKDSRTVTESRLPQES 494
A G ++AGT++ L + G PEP + W K + +T +P++S
Sbjct: 13698 A----------GLTVKAGTKIELPA-TVTGKPEPKITWTKADMILKQDKRITIENVPKKS 13746
Query: 495 RRVHLGSVEKSGSTFSRELVLVTG 518
+ S T+ E V V G
Sbjct: 13747 TVTIVDSKRSDTGTYIIEAVNVCG 13770
Score = 32.3 bits (72), Expect = 2.9
Identities = 22/88 (25%), Positives = 40/88 (45%), Gaps = 2/88 (2%)
Query: 935 LVSISRPDPPSGLKVVSLTPHSVGLEW-KPGFDGGLP-QRFCIRYEALGTPGFHYVDVVP 992
++++ DPP +++T H+V L+W KP + GG + + L + +
Sbjct: 21351 MLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSN 21410
Query: 993 PQATTFTLTGLQPSTRYRVWLLASNALG 1020
FT++GL Y ++A NA G
Sbjct: 21411 ILENEFTVSGLTEDAAYEFRVIAKNAAG 21438
Score = 32.3 bits (72), Expect = 2.9
Identities = 19/57 (33%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 914 DYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVS-LTPHSVGLEWKPGF-DGG 968
D + A N G + + + RP PP G V+S +T L WKP DGG
Sbjct: 22610 DSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGG 22666
Score = 32.3 bits (72), Expect = 2.9
Identities = 18/57 (31%), Positives = 26/57 (45%), Gaps = 2/57 (3%)
Query: 914 DYALFTCTATNALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEWKPGF-DGG 968
D + A+N GS + + + RP PP G ++V +T L W P DGG
Sbjct: 23692 DGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGG 23748
Score = 32.0 bits (71), Expect = 3.8
Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 13/114 (11%)
Query: 861 LHCRARGVPNIVFTWTKNGVPLDLQ---DPRYTEHTYHQGGVHSSLLTIANVSAAQDYAL 917
L+ +G P TW+K V L + D + T+ + L NV+ D
Sbjct: 19713 LYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDF--------DTFLRCENVNK-YDAGK 19763
Query: 918 FTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPG-FDGGLP 970
+ T N+ G + I + + P PP + V ++ S + W+P DGG P
Sbjct: 19764 YILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSP 19817
Score = 31.6 bits (70), Expect = 4.9
Identities = 20/94 (21%), Positives = 42/94 (44%), Gaps = 16/94 (17%)
Query: 456 RAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVL 515
+ G +L C +G P P + WY+ + + +SR + S + L +
Sbjct: 30545 KLGEAAQLSCQIVG-RPLPDIKWYRFGKELIQSR-----------KYKMSSDGRTHTLTV 30592
Query: 516 VTGPSDNQAKFTC----KAGQLSASTQLAVQFPP 545
+T +++ +TC + G++ S++L +Q P
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP 30626
Score = 31.2 bits (69), Expect = 6.4
Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 8/80 (10%)
Query: 859 ATLHCRAR--GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
A CR G P +V W +G PL+ + + + + V+ ++D
Sbjct: 1720 AHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYG------VAYSRDSG 1773
Query: 917 LFTCTATNALGSDQTNIQLV 936
+ TC ATN G+D T+ L+
Sbjct: 1774 IITCRATNKYGTDHTSATLI 1793
Score = 31.2 bits (69), Expect = 6.4
Identities = 33/155 (21%), Positives = 63/155 (40%), Gaps = 14/155 (9%)
Query: 229 KASFTVNVLFPPGPPVIEW-PGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVST 287
K S +NV+ PP +E+ L + VR + C N A ++W K+G +
Sbjct: 12362 KTSCNLNVV----PPHVEFLRPLTDLQVREKEMARFECELSREN--AKVKWFKDGAEIKK 12415
Query: 288 AWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILG 347
+ A +LV+ D A+ SCE + ++G + A+
Sbjct: 12416 GKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSG-------MLTVLEEEAVFTKN 12468
Query: 348 SASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLL 382
A+ ++ T+ V + S+P + W+ G +++
Sbjct: 12469 LANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEII 12503
Score = 31.2 bits (69), Expect = 6.4
Identities = 48/223 (21%), Positives = 84/223 (37%), Gaps = 36/223 (16%)
Query: 561 DALNLTCVSVSSNPPVNLSW-DKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQ 619
+ +N++ + +PP N+ W D+ + PP+ G + + +++ R +
Sbjct: 13577 EPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKN---DGGSRIKGYIVERCPRGSDK 13633
Query: 620 RVTCRAHSAELRETVSSF-------YRLNVLYR---------------------PE-FLG 650
V C AE + V+ YR+ L R PE FL
Sbjct: 13634 WVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLD 13693
Query: 651 EQVLVVTAVEQGEAL-LPVSVSANPAPEAFNWTFRGYRLSPAGGPR-HRILSSGALHLWN 708
++L V+ G + LP +V+ P P+ WT L + + + +
Sbjct: 13694 VKLLAGLTVKAGTKIELPATVTGKPEPK-ITWTKADMILKQDKRITIENVPKKSTVTIVD 13752
Query: 709 VTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEV 751
R+D G Y + N G A A + ++V P A D T+V
Sbjct: 13753 SKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDV 13795
Score = 30.8 bits (68), Expect = 8.4
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 42 TVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEAC 101
TV E C V+ P S +W +DG +P R E D + L I A
Sbjct: 2630 TVAESQEAVFECEVANPDSKGEWLRDG------KHLPLTNNIRSESDGHKR--RLIIAAT 2681
Query: 102 DLSDDAEYECQVGRSEMGPEL 122
L D EY +V S+ +L
Sbjct: 2682 KLDDIGEYTYKVATSKTSAKL 2702
Score = 30.8 bits (68), Expect = 8.4
Identities = 32/115 (27%), Positives = 47/115 (40%), Gaps = 13/115 (11%)
Query: 46 GASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSD 105
G+S C VS + W KDG + P+ R+ +G + LHI LSD
Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDGSNIRESPK----HRFIADGKDRK----LHIIDVQLSD 11184
Query: 106 DAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNC 160
EY C + +G + + L + P + T E VT V GQ ++C
Sbjct: 11185 AGEYTCVL---RLGNKEKTSTAKLVVEELPVRFVKTLE--EEVTVVKGQPLYLSC 11234
Score = 30.8 bits (68), Expect = 8.4
Identities = 14/30 (46%), Positives = 19/30 (63%)
Query: 39 ENLTVVEGASVELRCGVSTPGSAVQWAKDG 68
E+ TV EGA+ L C VS + V+W K+G
Sbjct: 12292 EDQTVEEGATAVLECEVSRENAKVKWFKNG 12321
Score = 30.8 bits (68), Expect = 8.4
Identities = 21/84 (25%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 659 VEQGEAL-LPVSVSANPAPEAFNWTFRGYRLSPAGGPRHR-ILSSGALHLWNVTRADDGL 716
++ GE+L + V P P W G + +L S +L + + TR G+
Sbjct: 27970 IKSGESLRIKALVQGRPVPRV-TWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGV 28028
Query: 717 YQLHCQNSEGTAEARLRLDVHYAP 740
Y + +N+ G+A+A +++ V P
Sbjct: 28029 YTVEAKNASGSAKAEIKVKVQDTP 28052
Score = 30.8 bits (68), Expect = 8.4
Identities = 42/146 (28%), Positives = 54/146 (36%), Gaps = 14/146 (9%)
Query: 103 LSDDAEYECQV------GRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEY 156
LS+ YE +V G G E P PPK L G +VT AG +
Sbjct: 29006 LSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDL 29065
Query: 157 VVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLV 216
V++ G KP P I I G D+ V+ K T A + RS + L
Sbjct: 29066 VLDAAVG-GKPEPKI-IWTKGDKELDLCEKVSLQYTGKRAT--AVIKFCDRSDSGKYTLT 29121
Query: 217 CEASSPALEAPIKASFTVNVLFPPGP 242
+ +S S V VL PGP
Sbjct: 29122 VKNAS----GTKAVSVMVKVLDSPGP 29143
Score = 30.8 bits (68), Expect = 8.4
Identities = 30/127 (23%), Positives = 53/127 (41%), Gaps = 14/127 (11%)
Query: 628 AELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQ------GEALLPVSVSANPAPEAFNW 681
++ + T S+ R PE + + ++VT ++ A V + P P A W
Sbjct: 32827 SDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI-W 32885
Query: 682 TFRGYRLSPAGGPRHRILSSGA-LHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAP 740
T G ++ G + G L + +D GLY +NS G+ + +L
Sbjct: 32886 TKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL------ 32939
Query: 741 TIRALQD 747
TI+A++D
Sbjct: 32940 TIKAIKD 32946
>gi|205277425 immunoglobulin superfamily, member 9 isoform a [Homo
sapiens]
Length = 1179
Score = 108 bits (269), Expect = 4e-23
Identities = 146/529 (27%), Positives = 210/529 (39%), Gaps = 79/529 (14%)
Query: 561 DALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQR 620
+ + L CV+ S P +++W G+ L +G ++ L++ + G
Sbjct: 152 EPVTLRCVARGSPLP-HVTWKLRGKDL---------GQGQGQVQVQNGTLRIRRVERGSS 201
Query: 621 --VTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVV-----TAVEQGEALLPVSVSAN 673
TC+A S E T ++ + LG V+VV T + L A
Sbjct: 202 GVYTCQASSTEGSATHATQLLV--------LGPPVIVVPPKNSTVNASQDVSLACHAEAY 253
Query: 674 PAPEAFNW------TFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGT 727
PA ++W F RL P R RIL G+L L D G Y C S G
Sbjct: 254 PANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYT--CVPSNGL 307
Query: 728 AE---ARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMF-NWERLGEDEE 783
A L V Y + A+ T + +G I C V ANP P +F +W + D +
Sbjct: 308 LHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANP--PLLFVSWTK---DGK 362
Query: 784 DQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDN-----GVAPPARRLLRLVVRFAP 838
LD S+G G L I G Y C N G +P R LL+ F
Sbjct: 363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF-- 420
Query: 839 QVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGG 898
+E P K + + C A+G P V +WTK G L Q
Sbjct: 421 -IERP----KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQ-----------GQAQ 464
Query: 899 VHSSLLTIANVSAAQDYALFTCTATNALG--SDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
V S+ I + + + C+A+NA+ + TN+ ++ S P + + VV+L P
Sbjct: 465 VDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS-PHVVTNVSVVAL-PKG 522
Query: 957 VGLEWKPGFDGGLPQRFCIRYEALG-TPGFHYVD----VVPPQATTFTLTGLQPSTRYRV 1011
+ W+PGFDGG QRF + Y L P + D VP A + GLQP T+Y+
Sbjct: 523 ANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQF 582
Query: 1012 WLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGL 1060
+LA N LG ++ P P G P ++P P S P GL
Sbjct: 583 SVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIP-PPLSPPRGL 630
Score = 58.2 bits (139), Expect = 5e-08
Identities = 77/346 (22%), Positives = 133/346 (38%), Gaps = 47/346 (13%)
Query: 259 QSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCE 318
+ + L CVARG +PL + W G+ + G Q + +R + G+
Sbjct: 152 EPVTLRCVARG-SPLPHVTWKLRGKDLGQGQGQVQVQNGT-----LRIRRVERGSSGVYT 205
Query: 319 AHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWW--- 375
S + G+ H L V PP ++ +++ +++V+L+C +++ + W+
Sbjct: 206 CQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
Query: 376 ---LGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKS 432
+L P ++DG +L LA + D+ TC + + S
Sbjct: 266 INVFHISRLQPRVRILVDG---------SLRLLATQPDDAGCYTCVPSNGLLHPPS--AS 314
Query: 433 LILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQ 492
L V YPAQ + P L G + C P + W KD + + + P
Sbjct: 315 AYLTVLYPAQ---VTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG 371
Query: 493 ESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC-------KAGQLSASTQLAVQFPP 545
S+ GS L++ G D +++C AG S T++ ++ PP
Sbjct: 372 WSQGTE-GS-----------LIIALGNEDALGEYSCTPYNSLGTAGP-SPVTRVLLKAPP 418
Query: 546 TNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVA 591
+ G L + C S +PP +SW K G L+G A
Sbjct: 419 AFIERPKEEYFQEVGRELLIPC-SAQGDPPPVVSWTKVGRGLQGQA 463
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 106 bits (265), Expect = 1e-22
Identities = 200/787 (25%), Positives = 284/787 (36%), Gaps = 128/787 (16%)
Query: 217 CEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATL 276
C A S A KA V P P ++ P + V G++ L C G P L
Sbjct: 379 CTAVSRAGTGRAKAQIVVT---DPPPQLVPAPNVT---VSPGETAVLSCRVLGEAPY-NL 431
Query: 277 QWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQV 336
W+++ + + + G Q S+ + + P D G + C A N+ G + L V
Sbjct: 432 TWVRDWRVLPASTGRV-AQLADLSLEISGIIPTD-GGRYQCVASNA--NGVTRASVWLLV 487
Query: 337 TFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGH 396
P I S ++ V +SC S S P + W + L +D
Sbjct: 488 REAPQVSIHTSSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVD------ 540
Query: 397 ISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLR 456
+ L ++ +C+A +E T + L+ PP +
Sbjct: 541 -AQGTLIIQGVAPEDAGNYSCQATNEVGTDQE------------TVTLYYTDPPSVSAVN 587
Query: 457 A------GTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFS 510
A G LVC A G P P ++WY+ + + GS+ S
Sbjct: 588 AVVLVAVGEEAVLVCEA-SGVPPPRVIWYRGGLEMI---------------LAPEGSS-S 630
Query: 511 RELVLVTGPSDNQAKFTCKA----GQLSASTQLAVQFPPTNVTILANASALRPGDALNLT 566
+L + + +TC+A G SA QLAV P +T L + G + L
Sbjct: 631 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-QLTELPRDVTVELGRSALLA 689
Query: 567 CVSVSSNPPVNLSWDKE-----GERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRV 621
C + PP ++W + G RL R P G SV + D V
Sbjct: 690 C-RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESV----APEDQAPYV 744
Query: 622 TCRAHSAELRETVSSFYRLNVL-YRPEFLGEQVLVVTAVEQGEALLPVSVSAN-PAPEAF 679
C A + + V + RL V + P + V +E LP V A P PE
Sbjct: 745 -CEARNVFGK--VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER- 800
Query: 680 NWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYA 739
+W G L P G RH I + G+LHL + G Y N+ G+ + L V
Sbjct: 801 HWLKDGRPLPP--GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP 858
Query: 740 PTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGP-- 797
P I N G + C P W + E +L SRGP
Sbjct: 859 PRIHPTATHHITNEGVPASLPCVASGVP--APTITWTK-----ETNAL-----TSRGPHY 906
Query: 798 ----TGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQV------EHPTPLT 847
G L I AGAY C N V ++ +RL V P++ PL
Sbjct: 907 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE-MRLSVNTKPRIHMNGSRNANVPLQ 965
Query: 848 KVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIA 907
A AG+ TL C A+G P + TWTK+ P+ RY G + S L +A
Sbjct: 966 VTAKAGE---EVTLDCEAKGSPPPLVTWTKDSRPVPPITNRY-------GLLPSGSLRLA 1015
Query: 908 NVSAAQDYALFTCTATNALGS----------DQTNIQLVSISRPDPP---SGLKVVSL-- 952
V D + CTA+N GS +T+ Q S+ P P SGL V L
Sbjct: 1016 QVQVG-DSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQP 1074
Query: 953 TPHSVGL 959
TP SV L
Sbjct: 1075 TPRSVRL 1081
Score = 74.3 bits (181), Expect = 7e-13
Identities = 138/540 (25%), Positives = 203/540 (37%), Gaps = 78/540 (14%)
Query: 414 TLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPE 473
T C A S A T K+ I+ P Q + P + G L C +G P
Sbjct: 376 TYECTAVSRAGTGRA--KAQIVVTDPPPQLV----PAPNVTVSPGETAVLSCRVLGEAPY 429
Query: 474 PSLMWYKDSRTVTESRLPQESRRV-HLG--SVEKSGSTFSRELVLVTGPSDNQAKFTCKA 530
+L W +D R LP + RV L S+E SG ++ T Q +
Sbjct: 430 -NLTWVRDWRV-----LPASTGRVAQLADLSLEISG-------IIPTDGGRYQCVASNAN 476
Query: 531 GQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGV 590
G AS L V+ P V+I ++ G + ++C S S P ++SW +E + L+
Sbjct: 477 GVTRASVWLLVREAP-QVSIHTSSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQ-- 532
Query: 591 AAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHS--AELRETVSSFYRLNVLYRPEF 648
+ A ++ V+ D G +C+A + +ETV+ +Y P
Sbjct: 533 ----EDSRIHVDAQGTLIIQGVAPEDAGN-YSCQATNEVGTDQETVTLYYT----DPPSV 583
Query: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYR--LSPAGGPRHRILSSGALHL 706
+V+ AV + EA+L S P P W G L+P G SSG L +
Sbjct: 584 SAVNAVVLVAVGE-EAVLVCEASGVPPPRVI-WYRGGLEMILAPEGS------SSGKLRI 635
Query: 707 WNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDAN 766
D G Y N G A A ++L V +AP + L V +G S + C
Sbjct: 636 PAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGR 695
Query: 767 PILPGMFNWERLGEDEEDQSLDDMEKISRG------PTGRLRIHHAKLAQAGAYQCIVDN 820
P P W R + Q L RG +G L Y C N
Sbjct: 696 P--PPTVTWRR----GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 749
Query: 821 GVAPPARRLLRLVV--RFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKN 878
V + RL+V PQ+ P +V G S + R +P W K+
Sbjct: 750 -VFGKVQAEARLIVTGHAPPQIASSAPTVRV-LEGQPVSLPCIVLAGRPLPE--RHWLKD 805
Query: 879 GVPLDLQDPRYTEHTYH-QGGVHSSLLTIANVSAAQDYA-LFTCTATNALGSDQTNIQLV 936
G PL P + H+ G +H A Q++A ++C ATN GS +++LV
Sbjct: 806 GRPL----PPGSRHSIRADGSLHLD-------RALQEHAGRYSCVATNTAGSQHRDVELV 854
Score = 67.8 bits (164), Expect = 6e-11
Identities = 120/482 (24%), Positives = 178/482 (36%), Gaps = 68/482 (14%)
Query: 43 VVEGASVELRCGVS-TPGSAVQWAKDGL--LLGPDPRIPGFPRYRLEGDPARGEFHLHIE 99
V G L C S P V W + GL +L P+ G L I
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG---------------KLRIP 636
Query: 100 ACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVN 159
A D Y C+ +E+G S + L++ P+L L + VT G+ ++
Sbjct: 637 AAQERDAGTYTCRAV-NELGD--ASAEIQLAVGHAPQLTELPRD----VTVELGRSALLA 689
Query: 160 CVSGDAKPAPDITILLS-GQTIS-DISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVC 217
C +P P +T GQ + + A S+Q V V P +++ VC
Sbjct: 690 C-RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP---EDQAPYVC 745
Query: 218 EASSPALEAPIKASFTVNVLFPP----GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
EA + + +A V PP P + V GQ + LPC+ G PL
Sbjct: 746 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVR--------VLEGQPVSLPCIVLAGRPL 797
Query: 274 ATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGIT 333
WLK+G+P+ G+ H+ A L + ++H + SC A N +AG+Q +
Sbjct: 798 PERHWLKDGRPLPP--GSRHS-IRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVE 852
Query: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
L V PP E +L CV+ S P + W +ET
Sbjct: 853 LVVQVPPRIHPTATHHITNEGVPASLPCVA-SGVPAPTITW---------TKETNALTSR 902
Query: 394 GGHISMSN----LTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGP 449
G H ++S L +D G + + F+ + + S+ +
Sbjct: 903 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
Query: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE-----SRLPQESRRVHLGSVEK 504
P +AG V L C A G+P P + W KDSR V LP S R+ V
Sbjct: 963 PLQVTAKAGEEVTLDCEA-KGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGD 1021
Query: 505 SG 506
SG
Sbjct: 1022 SG 1023
Score = 50.4 bits (119), Expect = 1e-05
Identities = 68/265 (25%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 707 WNVTRA---DDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTV 763
W + RA ++G Y+ + GT A+ ++ V P V+ G + + C V
Sbjct: 364 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV 423
Query: 764 DANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGR--------LRIHHAKLAQAGAYQ 815
LGE + + ++ TGR L I G YQ
Sbjct: 424 --------------LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
Query: 816 CIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTW 875
C+ N R + L+VR APQV T + + + C A G P +W
Sbjct: 470 CVASNANG-VTRASVWLLVREAPQVSIHTSSQHFSQGVE----VKVSCSASGYPTPHISW 524
Query: 876 TKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
++ L +D R H QG L I V A +D ++C ATN +G+DQ +
Sbjct: 525 SRESQALQ-EDSRI--HVDAQG-----TLIIQGV-APEDAGNYSCQATNEVGTDQ---ET 572
Query: 936 VSISRPDPPSGLKVVSLTPHSVGLE 960
V++ DPPS V ++ +VG E
Sbjct: 573 VTLYYTDPPSVSAVNAVVLVAVGEE 597
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 102 bits (254), Expect = 2e-21
Identities = 202/934 (21%), Positives = 363/934 (38%), Gaps = 131/934 (14%)
Query: 96 LHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSIL-VPPKLLLLTPEAGTMVTWVAGQ 154
L I+ ++ D +Y C L V LS++ PP++L + +T +G
Sbjct: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHL---HVTLSVVSYPPRILERRTKE---ITVHSGS 1761
Query: 155 EYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQL 214
+ C + +P+P +T +L+ QT+ S+ +GS+Q + TV+ T + S +R
Sbjct: 1762 TVELKC-RAEGRPSPTVTWILANQTVVSESS---QGSRQAVVTVDGTLVLHNLSIYDRGF 1817
Query: 215 LVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLA 274
C AS+P + S V + PPVI G+SL+LPC A+ G P
Sbjct: 1818 YKCVASNPGGQD----SLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAK-GTPQP 1872
Query: 275 TLQW-LKNGQPVSTAWGTEHTQAVAR--SVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHG 331
++ W L +G V T + ++ + + D G C A +S + +
Sbjct: 1873 SVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGT-YECIATSSTGSERRVVM 1931
Query: 332 ITLQ--VTFPPSAIIILGSASQTE---NKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEE 386
+T++ VT P I S +TE + L+C S + P+ + W L + ++ +
Sbjct: 1932 LTMEERVTSPR---IEAASQKRTEVNFGDKLLLNC-SATGEPKPQIMWRLPSKAVVDQQH 1987
Query: 387 TVMDGLH---GGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQK 443
V +H G + + ++T +D+G+ L C A + ++++V +
Sbjct: 1988 RVGSWIHVYPNGSLFIGSVT----EKDSGVYL-CVA-----RNKMGDDLILMHVSLRLKP 2037
Query: 444 LWIEGPPEGQK-LRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQE--SRRVHLG 500
I+ +K + G ++ C A G+P P + W T+ + + + R
Sbjct: 2038 AKIDHKQYFRKQVLHGKDFQVDCKA-SGSPVPEISWSLPDGTMINNAMQADDSGHRTRRY 2096
Query: 501 SVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALR-- 558
++ +G+ + ++ + + +TC A ++ V ++T++ A +R
Sbjct: 2097 TLFNNGTLYFNKVGVA-----EEGDYTCYAQNTLGKDEMKV-----HLTVITAAPRIRQS 2146
Query: 559 --------PGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLL 610
GD L C V+ +P + W + + GS V L
Sbjct: 2147 NKTNKRIKAGDTAVLDC-EVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKL 2205
Query: 611 QVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPE-----FLGEQVLVVTAVEQGEAL 665
D G+ V C A + +T Y+L+V+ +P + V+ TAV +
Sbjct: 2206 ----LDSGEYV-CVARNPSGDDT--KMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
Query: 666 LPVSVSANPAPEAFNWTFRG--YRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQN 723
P+PE W + +P G R + +G L + NV +D + +N
Sbjct: 2259 FDCRAEGTPSPEVM-WIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317
Query: 724 SEGTAEARLRLDV---HYAPTIR-ALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLG 779
G + ++L+V PT R + +G S + C+VD NP P W
Sbjct: 2318 EGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNP--PPEIIW---- 2371
Query: 780 EDEEDQSLDDMEKISRGP---------TGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLL 830
L + + S GP G I AG Y+C N V +L+
Sbjct: 2372 ------ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG-YIEKLV 2424
Query: 831 RLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWT-KNGVPLDLQDPRY 889
L + P + P T +G+S S LHC + G+P WT +G +D +
Sbjct: 2425 ILEIGQKPVILTYAPGTVKGISGESLS---LHCVSDGIPKPNIKWTMPSGYVVD-RPQIN 2480
Query: 890 TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKV 949
++ H G + + A D + C A N++G + ++ ++ P ++
Sbjct: 2481 GKYILHDNGT-----LVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPP-----RI 2530
Query: 950 VSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTP 983
+ P S+ F Q C+ ALG P
Sbjct: 2531 TNRPPRSIVTRTGAAF-----QLHCV---ALGVP 2556
Score = 81.3 bits (199), Expect = 5e-15
Identities = 169/718 (23%), Positives = 269/718 (37%), Gaps = 86/718 (11%)
Query: 255 VRAGQSLELPCVARGGNPLATLQWLK--NGQPVSTAWGTEHTQAVARSVL-VMTVRPEDH 311
+ A LPC A G NPL T+ W + +G +S Q + L + V +D
Sbjct: 1660 IPANSDAFLPCEAVG-NPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDR 1718
Query: 312 GAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQT--ENKNVTLSCVSKSSRPR 369
G Q C A N GT +TL V P I+ + T V L C ++ RP
Sbjct: 1719 G-QYLCSASNLF--GTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAE-GRPS 1774
Query: 370 VLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKET- 428
+ W +L + V + G ++ +T + L++ F +
Sbjct: 1775 PTVTW------ILANQTVVSESSQGSRQAV--VTVDGTLVLHNLSIYDRGFYKCVASNPG 1826
Query: 429 FKKSLILNVKYPAQKLWIEGPPEGQKLRA-------GTRVRLVCLAIGGNPEPSLMWYKD 481
+ SL++ ++ I PP + R G ++L C A G P+PS+ W
Sbjct: 1827 GQDSLLVKIQV------IAAPPVILEQRRQVIVGTWGESLKLPCTA-KGTPQPSVYWVLS 1879
Query: 482 SRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAV 541
T + L + ++ L S +G+ + R L S ++ + C A + S + V
Sbjct: 1880 DGTEVKP-LQFTNSKLFLFS---NGTLYIRNLA-----SSDRGTYECIATSSTGSERRVV 1930
Query: 542 QF-------PPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSW--------DKEGER 586
P + + GD L L C S + P + W D++
Sbjct: 1931 MLTMEERVTSPRIEAASQKRTEVNFGDKLLLNC-SATGEPKPQIMWRLPSKAVVDQQHRV 1989
Query: 587 LEGVAAPPRRAPFKGSAAAR--SVLLQVSSRDHGQRVTCRAHSAELRETV---SSFYRLN 641
+ P + F GS + V L V+ G + S L+ ++R
Sbjct: 1990 GSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQ 2049
Query: 642 VLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSS 701
VL+ +F + + V + LP N A +A + G+R R+ + ++
Sbjct: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADD---SGHRTR-----RYTLFNN 2101
Query: 702 GALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV-HYAPTIRALQDPTE-VNVGGSVDI 759
G L+ V A++G Y + QN+ G E ++ L V AP IR + + G + +
Sbjct: 2102 GTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVL 2161
Query: 760 VCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVD 819
C V +P P +F W D S+D + + G L I+ KL +G Y C+
Sbjct: 2162 DCEVTGDP-KPKIF-WLLPSNDMISFSID---RYTFHANGSLTINKVKLLDSGEYVCVAR 2216
Query: 820 NGVAPPARRLLRLVVRFAPQVEH-PTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKN 878
N + VV P + T T + A S CRA G P+ W
Sbjct: 2217 NPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMP 2276
Query: 879 GVPLDLQDPRY-TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
+ L P Y + T H+ G L I NV + D A F C A N G +QL
Sbjct: 2277 D-NIFLTAPYYGSRITVHKNGT----LEIRNVRLS-DSADFICVARNEGGESVLVVQL 2328
Score = 73.9 bits (180), Expect = 9e-13
Identities = 112/497 (22%), Positives = 186/497 (37%), Gaps = 46/497 (9%)
Query: 463 LVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDN 522
L C A+G NP P++ W + + S+ Q SR L T S + V + +
Sbjct: 1668 LPCEAVG-NPLPTIHWTRVPSGLDLSKRKQNSRVQVL-----PNGTLSIQRVEI----QD 1717
Query: 523 QAKFTCKAGQLSASTQL-----AVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVN 577
+ ++ C A L + L V +PP + + G + L C P
Sbjct: 1718 RGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC-RAEGRPSPT 1776
Query: 578 LSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSF 637
++W + + ++ R + VL +S D G C A + ++ S
Sbjct: 1777 VTWILANQTVVSESSQGSRQAVV-TVDGTLVLHNLSIYDRG-FYKCVASNPGGQD--SLL 1832
Query: 638 YRLNVLYRPEFLGEQVLVVTAVEQGEAL-LPVSVSANPAPEAFNWTFRGYRLSPAGGPRH 696
++ V+ P + EQ V GE+L LP + P P + G + P
Sbjct: 1833 VKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNS 1892
Query: 697 R--ILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVH---YAPTIRAL-QDPTE 750
+ + S+G L++ N+ +D G Y+ +S G+ + L + +P I A Q TE
Sbjct: 1893 KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTE 1952
Query: 751 VNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQ 810
VN G + + C+ P W + DQ I P G L I
Sbjct: 1953 VNFGDKLLLNCSATGEP--KPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD 2010
Query: 811 AGAYQCIVDNGVAPPARRLLRLVVRFAP-QVEHPTPLTKVAAAGDSTSSATLHCRARGVP 869
+G Y C+ N + L+ + +R P +++H K G + C+A G P
Sbjct: 2011 SGVYLCVARNKMGDDL-ILMHVSLRLKPAKIDHKQYFRKQVLHG---KDFQVDCKASGSP 2066
Query: 870 NIVFTWT-------KNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTA 922
+W+ N + D R +T G L V A++ +TC A
Sbjct: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGT----LYFNKVGVAEE-GDYTCYA 2121
Query: 923 TNALGSDQTNIQLVSIS 939
N LG D+ + L I+
Sbjct: 2122 QNTLGKDEMKVHLTVIT 2138
Score = 72.4 bits (176), Expect = 3e-12
Identities = 80/303 (26%), Positives = 115/303 (37%), Gaps = 16/303 (5%)
Query: 640 LNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPR---H 696
L +L RP F + A L SV NP PE G R S GP+ +
Sbjct: 2331 LEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS--NGPQSYQY 2388
Query: 697 RILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGG- 755
I S+G+ + TR D G Y+ +N G E + L++ P I T + G
Sbjct: 2389 LIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGE 2448
Query: 756 SVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQ 815
S+ + C D P W D+ + + I G L I A G Y
Sbjct: 2449 SLSLHCVSDGIP--KPNIKWTMPSGYVVDRPQINGKYILH-DNGTLVIKEATAYDRGNYI 2505
Query: 816 CIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTW 875
C N V + ++V + P++ + P + V G ++ LHC A GVP TW
Sbjct: 2506 CKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTG---AAFQLHCVALGVPKPEITW 2562
Query: 876 TKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSD--QTNI 933
L E T+ +H + D ++ CTA N LGSD T I
Sbjct: 2563 EM--PDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYI 2620
Query: 934 QLV 936
Q++
Sbjct: 2621 QVI 2623
Score = 61.2 bits (147), Expect = 6e-09
Identities = 71/309 (22%), Positives = 116/309 (37%), Gaps = 17/309 (5%)
Query: 642 VLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTF--RGYRLSP-AGGPRHRI 698
+ +P +G + T +A LP NP P +WT G LS R ++
Sbjct: 1644 IFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLP-TIHWTRVPSGLDLSKRKQNSRVQV 1702
Query: 699 LSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLD-VHYAPTI--RALQDPTEVNVGG 755
L +G L + V D G Y N GT + L V Y P I R ++ T V+ G
Sbjct: 1703 LPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEIT-VHSGS 1761
Query: 756 SVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQ 815
+V++ C + P W + +S + G L +H+ + G Y+
Sbjct: 1762 TVELKCRAEGRP--SPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYK 1819
Query: 816 CIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTW 875
C+ N + + V+ P + V G+S L C A+G P W
Sbjct: 1820 CVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLK---LPCTAKGTPQPSVYW 1876
Query: 876 TKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL 935
V D + + + T + + S+ A+ D + C AT++ GS++ + L
Sbjct: 1877 ----VLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVML 1932
Query: 936 VSISRPDPP 944
R P
Sbjct: 1933 TMEERVTSP 1941
Score = 36.6 bits (83), Expect = 0.15
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 4/102 (3%)
Query: 855 STSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQD 914
+ S A L C A G P WT+ LDL + + + L+I V QD
Sbjct: 1662 ANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV---LPNGTLSIQRVEI-QD 1717
Query: 915 YALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
+ C+A+N G+D ++ L +S P + +T HS
Sbjct: 1718 RGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHS 1759
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 102 bits (253), Expect = 3e-21
Identities = 176/747 (23%), Positives = 288/747 (38%), Gaps = 95/747 (12%)
Query: 339 PPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQL-LPMEETVMDGLHGGHI 397
P ++I +GS E+K +TL C ++ + P RW L + + ME L+GG++
Sbjct: 32 PSNSIFPVGS----EDKKITLHCEARGN-PSPHYRWQLNGSDIDMSMEHRYK--LNGGNL 84
Query: 398 SMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQK--- 454
+ N R D G T C A + T I++ + Q ++E +
Sbjct: 85 VVINPN---RNWDTG-TYQCFATNSLGT--------IVSREAKLQFAYLENFKTKMRSTV 132
Query: 455 -LRAGTRVRLVCLAIGGNPEPSLMWYKD---SRTVTESR--LPQESRRVHLGSVEKSGST 508
+R G V L+C + E S W + S +SR + QE+ +++ VE S
Sbjct: 133 SVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSD-- 190
Query: 509 FSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCV 568
+VT N + S + ++ P G + L C
Sbjct: 191 VGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECF 250
Query: 569 SVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAAR--SVLLQVSS--RDHGQRVTCR 624
++ NP ++W R +G+ PF R S +L++ + ++ C
Sbjct: 251 ALG-NPIPQINW----RRSDGL-------PFSSKIKLRKFSGVLEIPNFQQEDAGSYECI 298
Query: 625 AHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFR 684
A ++ + RL +P ++ V AVE S P P ++ W
Sbjct: 299 AENSRGKNVARG--RLTYYAKPHWVQLIKDVEIAVEDS-LYWECRASGKPKP-SYRWLKN 354
Query: 685 GYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV-HYAPTI- 742
G L + + +GAL + N++ D G++Q +N G + L V AP
Sbjct: 355 GAALVLEERTQ---IENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFS 411
Query: 743 -RALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRL 801
++ +V VG V + C A+P + +W++ D S+ + E+IS G L
Sbjct: 412 KNPMKKLVQVQVGSLVSLDCKPRASP--RALSSWKK-----GDVSVQEHERISLLNDGGL 464
Query: 802 RIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST--SSA 859
+I + A AG Y C+ +N A LVV PT +T + D + S
Sbjct: 465 KIANVTKADAGTYTCMAENQFGK-ANGTTHLVVT------EPTRITLAPSNMDVSVGESV 517
Query: 860 TLHCRARGVP--NIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYAL 917
L C+ + P +I+FTW NG D + + H GG S L I N+
Sbjct: 518 ILPCQVQHDPLLDIIFTWYFNGALADFK--KDGSHFEKVGGSSSGDLMIRNIQLKHS-GK 574
Query: 918 FTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQ-RFCIR 976
+ C + S + L+ P PP +KV +T + L WK G D P + I+
Sbjct: 575 YVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQ 634
Query: 977 YEALGTPGFHYVDVVPP----QATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLP 1032
+ G+ V VP + T T+ L P Y ++ASN +G
Sbjct: 635 ARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGG---------- 684
Query: 1033 ITTPGLHQPSGEPEDQLPTEPPSGPSG 1059
P L E+ +P PPS +G
Sbjct: 685 --EPSLPSEKVRTEEAVPEVPPSEVNG 709
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 99.0 bits (245), Expect = 3e-20
Identities = 138/613 (22%), Positives = 223/613 (36%), Gaps = 59/613 (9%)
Query: 458 GTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR---LPQESRRVHLGSVEKSGSTFSRELV 514
G L L I P P + W+++ + S + E++ V L + + + V
Sbjct: 205 GRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAV 264
Query: 515 LVTGPSDNQAKFTCKAGQLSASTQLAVQ--FPPTNVTILANASALRPGDALNLTCVSVSS 572
+ + F LS + + PT V N S + L C++ S+
Sbjct: 265 NEKNGENKTSPFI----HLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIA-SA 319
Query: 573 NPPVNLS--WDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAEL 630
P +LS W + G R+ S R + +S D G V A
Sbjct: 320 RPVEDLSVTWKRNGVRITSGLH---------SFGRRLTISNPTSADTGPYVCEAALPGSA 370
Query: 631 RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSP 690
E + L ++ P F E ++A + + P P W +S
Sbjct: 371 FEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLP-TLQWYKDAISISR 429
Query: 691 AGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDV-HYAPTIRALQDPT 749
PR+++L+SG L + + D G++Q N G + LDV + AP T
Sbjct: 430 LQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDT 489
Query: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
V G + + C V P W+R S+ + + +G L+I +
Sbjct: 490 TVTDGMTAILRCEVSGAP--KPAITWKRENHILASGSV-RIPRFMLLESGGLQIAPVFIQ 546
Query: 810 QAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVP 869
AG Y C N L V + HP P V G ++ATLHC A P
Sbjct: 547 DAGNYTCYAAN-TEGSLNASATLTVWNRTSIVHP-PEDHVVIKG---TTATLHCGATHDP 601
Query: 870 NIV--FTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG 927
+ + W K+ V L T + + V + + + + D ++C + G
Sbjct: 602 RVSLRYVWKKDNVAL-------TPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGG 654
Query: 928 SDQTNIQLVSISRPDPPSGLKVV--SLTPHSVGLEWKPGFDGGLP-QRFCIRYEALGTPG 984
+D +L I P P L V S H+V L W FDG P + + +P
Sbjct: 655 NDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPW 714
Query: 985 FHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGE 1044
++ V P+ T T++GL P+ Y+ + A N +G + + ++L
Sbjct: 715 KVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRL------------- 761
Query: 1045 PEDQLPTEPPSGP 1057
LP EPPS P
Sbjct: 762 ---MLPEEPPSAP 771
Score = 51.6 bits (122), Expect = 5e-06
Identities = 131/548 (23%), Positives = 209/548 (38%), Gaps = 85/548 (15%)
Query: 34 FWALPENLTVVEG--ASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPAR 91
F + TV +G A + L S P V W ++G + P RI
Sbjct: 193 FMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIA-----------IT 241
Query: 92 GEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSI---LVPPKLL---LLTPEAG 145
E L I A SD Y Q + G SP + LSI + P+ + ++ P
Sbjct: 242 LENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGN 301
Query: 146 TMVTWVAGQ-EYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARV 204
V VAG E + C++ A+P D+++ + S + G + +
Sbjct: 302 RSV--VAGSSETTLECIAS-ARPVEDLSVTWKRNGVRITSGLHSFGRRLTISN------- 351
Query: 205 TPRSSDNRQLLVCEASSPALE-APIKASFTVNVLFPPGPPVIEWPGLDEGHVRAG--QSL 261
P S+D VCEA+ P P +A+ + ++ PP + E + A +++
Sbjct: 352 -PTSADTGPY-VCEAALPGSAFEPARATAFLFIIEPP-----YFTAEPESRISAEVEETV 404
Query: 262 ELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHN 321
++ C A G PL TLQW K+ +S + + + + +RPED G C A N
Sbjct: 405 DIGCQAMGV-PLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGI-FQCFASN 462
Query: 322 SVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSC-VSKSSRPRVLLRWWLGWRQ 380
Q H P + T+ L C VS + +P + W
Sbjct: 463 E-GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAIT---WKRENH 518
Query: 381 LLPMEETVMDG---LHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNV 437
+L + L G + ++ + +D G TC A A T+ + S L V
Sbjct: 519 ILASGSVRIPRFMLLESGGLQIAPVFI----QDAG-NYTCYA---ANTEGSLNASATLTV 570
Query: 438 KYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSL--MWYKDSRTVTESRLPQESR 495
+ I PPE + GT L C A +P SL +W KD+ +T P +
Sbjct: 571 ---WNRTSIVHPPEDHVVIKGTTATLHCGAT-HDPRVSLRYVWKKDNVALT----PSSTS 622
Query: 496 RVHLGSVEKSGS-----TFSRELVLVTGPSDNQAKFTCKAGQLSASTQL-AVQFP--PTN 547
R+ VEK GS T+S ++ D + + G S +L ++ P P N
Sbjct: 623 RI---VVEKDGSLLISQTWSGDI------GDYSCEIVSEGGNDSRMARLEVIELPHSPQN 673
Query: 548 VTILANAS 555
+ + N+S
Sbjct: 674 LLVSPNSS 681
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/125 (32%), Positives = 59/125 (47%), Gaps = 8/125 (6%)
Query: 940 RPDPPSGLKV--VSLTPHSVGLEWKPGFDGGLPQR-FCIRYEALGTPGFH-YVDVVPPQA 995
RP PP L V +T S+ L+W PG DG P R F ++ L + Y + +A
Sbjct: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEA 1535
Query: 996 TTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPS 1055
T + L+P T Y++ L A+N +GDS + + +TT L GEP + P +
Sbjct: 1536 TACVVDRLRPFTSYKLRLKATNDIGDSDFSSETE--AVTT--LQDVPGEPPGSVSATPHT 1591
Query: 1056 GPSGL 1060
S L
Sbjct: 1592 TSSVL 1596
Score = 39.7 bits (91), Expect = 0.018
Identities = 38/139 (27%), Positives = 56/139 (40%), Gaps = 13/139 (9%)
Query: 890 TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKV 949
T H Y G+ S LT + A A+ T T++ S L P PS L +
Sbjct: 1026 TTHEYKIQGLSS--LTTYTIDVAAVTAVGTGLVTSSTISSGVPPDL-----PGAPSNLVI 1078
Query: 950 VSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFH------YVDVVPPQATTFTLTGL 1003
+++P S L+++PG+DG I +G G Y + P A + L
Sbjct: 1079 SNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNL 1138
Query: 1004 QPSTRYRVWLLASNALGDS 1022
P T YR + N +G S
Sbjct: 1139 TPYTHYRFRMKQVNIVGPS 1157
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 97.8 bits (242), Expect = 6e-20
Identities = 161/764 (21%), Positives = 276/764 (36%), Gaps = 82/764 (10%)
Query: 202 ARVTPRSSDNRQLLVCEAS-SPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQS 260
AR P + L+C S A+E P+ S + PP I + V +
Sbjct: 2 ARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELT---QPPTITKQSAKDHIVDPRDN 58
Query: 261 LELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVR----PEDHGAQLS 316
+ + C A+G NP + W +N + + A + LV+ R PE++ +
Sbjct: 59 ILIECEAKG-NPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQ 117
Query: 317 CEAHNSVSAGTQEHGITLQVTFPPS-AIIILGSASQTENKNVTLSCVSKSSRPRVLLRWW 375
C A N I LQV+ P L E +TL C P ++ W
Sbjct: 118 CFARNKFGTALSNR-IRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 176
Query: 376 LGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEA---FSEAFTKETFKKS 432
+ + ++ V G H G + SN+ +D +C A F+ ++
Sbjct: 177 SSSMEPITQDKRVSQG-HNGDLYFSNVML----QDMQTDYSCNARFHFTHTIQQKNPFTL 231
Query: 433 LILNVKYPAQK----LWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTES 488
+L + A++ ++ +G Q + G + L C+A G P P + WYK +
Sbjct: 232 KVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA-SGVPTPDIAWYKKGGDLPSD 290
Query: 489 RLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFP 544
+ E+ F++ L + ++ ++ C K G + + + V+
Sbjct: 291 KAKFEN--------------FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
Query: 545 PTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAA 604
P + N L PG+ L C + NP + W GE L+ P R +
Sbjct: 337 PYWLDEPKNL-ILAPGEDGRLVC-RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII 394
Query: 605 ARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEA 664
R Q+SSR Q T H L S + P L + ++ +
Sbjct: 395 FRDT--QISSRAVYQCNTSNEHGYLLANAFVSVLDVP----PRMLSPRNQLIRVILYNRT 448
Query: 665 LLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNS 724
L +P P W G + GG H + +G+L + + + D G+Y N
Sbjct: 449 RLDCPFFGSPIP-TLRWFKNGQGSNLDGGNYH-VYENGSLEIKMIRKEDQGIYTCVATNI 506
Query: 725 EGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEED 784
G AE ++RL+V I + + G +V + C V +P L +W L +DE
Sbjct: 507 LGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW--LKDDEPL 564
Query: 785 QSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPT 844
+ M+K L I G+Y C+ + + V+ + T
Sbjct: 565 YIGNRMKK----EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL-----ADQAT 615
Query: 845 PLTKVAA--AGDSTSSATLHCRARGVPNIVFTW---TKNGVPL----------DLQDPRY 889
P ++AA G L ++ TW N P+ Q +
Sbjct: 616 PTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVW 675
Query: 890 TEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNI 933
+H+ + G V+S++L ++ Q F A N +GS ++
Sbjct: 676 HDHSKYPGSVNSAVLRLSPYVNYQ----FRVIAINEVGSSHPSL 715
Score = 73.2 bits (178), Expect = 1e-12
Identities = 143/645 (22%), Positives = 237/645 (36%), Gaps = 94/645 (14%)
Query: 422 EAFTKETFKKSLILNVKYPAQK--LWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWY 479
+ F + F +L ++ K LW + + ++ G + L C G P P + W
Sbjct: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 176
Query: 480 KDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQL 539
S + +RV G +G + ++L D Q ++C A T
Sbjct: 177 SSSMEPIT-----QDKRVSQGH---NGDLYFSNVML----QDMQTDYSCNAR--FHFTHT 222
Query: 540 AVQFPPTNVTIL------------------ANASALRPGDALNLTCVSVSSNPPVNLSWD 581
Q P + +L A++ + G L L C++ S P +++W
Sbjct: 223 IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA-SGVPTPDIAWY 281
Query: 582 KEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHS-AELRETVSSFYRL 640
K+G L P +A F+ A + VS D G+ ++ +R T+S +
Sbjct: 282 KKGGDL-----PSDKAKFENFNKALRIT-NVSEEDSGEYFCLASNKMGSIRHTIS----V 331
Query: 641 NVLYRPEFLGE-QVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRIL 699
V P +L E + L++ E G L + NP P W G L A +R +
Sbjct: 332 RVKAAPYWLDEPKNLILAPGEDGR--LVCRANGNPKPTV-QWMVNGEPLQSAPPNPNREV 388
Query: 700 SSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTE---VNVGGS 756
+ + + + +YQ + N G A + V P R L + V +
Sbjct: 389 AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP-RMLSPRNQLIRVILYNR 447
Query: 757 VDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQC 816
+ C +PI W + G+ S D G L I + G Y C
Sbjct: 448 TRLDCPFFGSPI--PTLRWFKNGQG----SNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 501
Query: 817 IVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFT-- 874
+ N + A +RL V+ ++ + P +VA G ++ L CR + P++ T
Sbjct: 502 VATN-ILGKAENQVRLEVKDPTRI-YRMPEDQVARRG---TTVQLECRVKHDPSLKLTVS 556
Query: 875 WTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQ 934
W K+ PL + + E LTI V A +D +TC A+ L D
Sbjct: 557 WLKDDEPLYIGNRMKKE---------DDSLTIFGV-AERDQGSYTCVASTELDQDLAKAY 606
Query: 935 LVSIS---------------RPDPPSGLKVVSLTPHSVGLEWKPGFDGGLP-QRFCIRYE 978
L ++ RPD P L++ L SV L W PG P + +++E
Sbjct: 607 LTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFE 666
Query: 979 A-LGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDS 1022
PG + P + + L P Y+ ++A N +G S
Sbjct: 667 EDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSS 711
Score = 37.7 bits (86), Expect = 0.069
Identities = 33/118 (27%), Positives = 48/118 (40%), Gaps = 10/118 (8%)
Query: 941 PDPPSGLKVVSLTPHSVGLEWK-PGFDGGLPQRFCIRYEAL-GTP-GFHYVDVVPPQATT 997
P P +V ++ LEW P G+ + ++Y A GT G V+ P T
Sbjct: 825 PSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTK 884
Query: 998 FTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPS 1055
FT+ P +RYR L A +G + + P P P+ P PT PP+
Sbjct: 885 FTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAP---PNEATPTAAP----PTLPPT 935
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 96.3 bits (238), Expect = 2e-19
Identities = 153/679 (22%), Positives = 244/679 (35%), Gaps = 97/679 (14%)
Query: 380 QLLPMEETVMDGL-HGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVK 438
QL+P E V G HG I S+ +DN L T +E F + V+
Sbjct: 26 QLIPDPEDVERGNDHGTPIPTSD------NDDNSLGYT----GSRLRQEDFPPRI---VE 72
Query: 439 YPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVH 498
+P+ + +G P +A G P P++ WYK V + S R+
Sbjct: 73 HPSDLIVSKGEPATLNCKAE-----------GRPTPTIEWYKGGERVETDKDDPRSHRML 121
Query: 499 LGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQL-------SASTQLAV-----QFPPT 546
L SGS F +V ++ + C A +AS ++A+ + P+
Sbjct: 122 L----PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
Query: 547 NVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAAR 606
+V + A+ + C +P +SW K+G L+ R +G +
Sbjct: 178 DVMVAVGEPAV-------MECQPPRGHPEPTISWKKDGSPLDD---KDERITIRGG---K 224
Query: 607 SVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALL 666
++ D G+ V + RE S L VL RP F+ + V+ A
Sbjct: 225 LMITYTRKSDAGKYVCVGTNMVGERE--SEVAELTVLERPSFVKRPSNLAVTVDDS-AEF 281
Query: 667 PVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEG 726
+P P W L + R+ I L + VT D G Y +N G
Sbjct: 282 KCEARGDPVPTV-RWRKDDGELPKS---RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 337
Query: 727 TAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDE---E 783
AEA L V P V +G +V C NP P +F W R G
Sbjct: 338 KAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP-QPAIF-WRREGSQNLLFS 395
Query: 784 DQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQC----IVDNGVAPPARRLLRLVVRFAPQ 839
Q + S TG L I + + + G Y C + + + + ++ P
Sbjct: 396 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 455
Query: 840 VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGV 899
V P+ + A + L C A G P W K+GV + QD R + +
Sbjct: 456 VIRQGPVNQTVAV---DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ-------L 505
Query: 900 HSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQL------VSISRPDP---------P 944
+ +L I + D +TC A+ G + + V + P P P
Sbjct: 506 ENGVLQI-RYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 564
Query: 945 SGLKVVSLTPHSVGLEWKPGFD-GGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGL 1003
S +V ++ ++V L W+P + G P + I + + + T + GL
Sbjct: 565 SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGL 624
Query: 1004 QPSTRYRVWLLASNALGDS 1022
+P+ Y + A+NA G S
Sbjct: 625 KPNAIYLFLVRAANAYGIS 643
Score = 48.9 bits (115), Expect = 3e-05
Identities = 78/344 (22%), Positives = 128/344 (37%), Gaps = 37/344 (10%)
Query: 38 PENLTVVEGASVELRCGV-STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
P NL V S E +C P V+W KD D +P RY + D L
Sbjct: 268 PSNLAVTVDDSAEFKCEARGDPVPTVRWRKD------DGELPK-SRYEIRDDHT-----L 315
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEY 156
I D Y C V + +G S L++ PP ++ + + G+
Sbjct: 316 KIRKVTAGDMGSYTC-VAENMVGKAEAS--ATLTVQEPPHFVVKPRDQVVAL----GRTV 368
Query: 157 VVNC-VSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQL- 214
C +G+ +PA I + ++ + F+V T +T + +
Sbjct: 369 TFQCEATGNPQPA----IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 424
Query: 215 -LVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
+C+ + A KA V + PP + G V + L CVA G +P+
Sbjct: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG-SPV 483
Query: 274 ATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSC-------EAHNSVSAG 326
T+ W K+G VST + + VL + + +C EA S
Sbjct: 484 PTILWRKDGVLVSTQ--DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 541
Query: 327 TQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRV 370
QE G+ +Q P +I + S+ E +V+ + V+ S +P +
Sbjct: 542 VQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 585
>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
Length = 583
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/299 (29%), Positives = 130/299 (43%), Gaps = 33/299 (11%)
Query: 79 GFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLL 138
G+ RY + G+ A G+ LHI +L D+A YECQ ++ L S L +LVPP+
Sbjct: 21 GWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA----GLRSRPAQLHVLVPPEAP 76
Query: 139 LLTPEAGTMVTWVAGQEYVVNCVS-GDAKPAPDIT-----ILLSGQTISDISANVNEGSQ 192
+ G V+ VAG + C S GDA+P P++ +LL G T + EG+
Sbjct: 77 QVL--GGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFH--QTLLKEGTP 132
Query: 193 QKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDE 252
+VE+T +TP S D+ VC A S AL + T+++ +PP + P
Sbjct: 133 G---SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT-- 187
Query: 253 GHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHG 312
V+ G+ + C A P+ +W K G PV A G S L V
Sbjct: 188 --VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV------ 239
Query: 313 AQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSS-RPRV 370
SCE N+V G+ L V F P S ++ + SC + + PRV
Sbjct: 240 ---SCEVSNAV--GSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRV 293
Score = 82.0 bits (201), Expect = 3e-15
Identities = 110/430 (25%), Positives = 172/430 (40%), Gaps = 56/430 (13%)
Query: 521 DNQAKFTCKAGQL---SASTQLAVQFPPTNVTILANAS-ALRPGDALNLTCVSVS-SNPP 575
+++A + C+A Q S QL V PP +L S +L G NLTC S + P
Sbjct: 46 EDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPT 105
Query: 576 VNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL-LQVSSRDHGQRVTCRAHSAELRETV 634
L W ++G L+G + S L L S D G CRA S L
Sbjct: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
Query: 635 SSFYRLNVLYRPEFLGEQVLVVTA----VEQGEALLPV-SVSANPAPEAFNWTFRGYRLS 689
+ L++ Y PE + ++A V++GE ++ + +A P + W G +
Sbjct: 166 DTAITLSLQYPPE------VTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL 219
Query: 690 PAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPT 749
A GPR +++ + V+ N+ G+A LDV + P ++A +P
Sbjct: 220 GARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 271
Query: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
V+VG C NP LP + W R G + + G T LR+
Sbjct: 272 SVDVGEDASFSCAWRGNP-LPRV-TWTRRG---------GAQVLGSGAT--LRLPSVGPE 318
Query: 810 QAGAYQCIVDNGVA--PPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARG 867
AG Y C + G++ RL V P V T L +A A L C
Sbjct: 319 DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV---TALH--SAPAFLRGPARLQCLVFA 373
Query: 868 VP---NIVFTWTKNGVPLDLQDPRYTEHTY----HQGGVHSSLLTIANVSAAQDYAL--- 917
P +V++W + + Q R+ T+ +GG+ L+++ ++S Q+
Sbjct: 374 SPAPDAVVWSWDEGFLEAGSQG-RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 432
Query: 918 FTCTATNALG 927
F C+A N LG
Sbjct: 433 FNCSARNRLG 442
Score = 60.5 bits (145), Expect = 1e-08
Identities = 98/396 (24%), Positives = 151/396 (38%), Gaps = 66/396 (16%)
Query: 204 VTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-GPPVIEWPGLDEGHVRAGQSLE 262
+ P ++ C+A+ L + ++VL PP P V+ P + + AG
Sbjct: 40 IRPVELEDEASYECQATQAGLRS---RPAQLHVLVPPEAPQVLGGPSVS---LVAGVPAN 93
Query: 263 LPCVARG-GNPLATLQWLKNGQPVSTAWG-----TEHTQAVARSVLVMTVRPEDHGAQLS 316
L C +RG P L W ++G + A E T S L +T D GA
Sbjct: 94 LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
Query: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376
C A + ++ ITL + +PP + + E + V C + + P RW
Sbjct: 154 CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
Query: 377 GWRQLLPMEETVMDGLHGGHIS-MSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLIL 435
G +L G G + +++ +FL ++CE + + +S L
Sbjct: 214 GGSPVL--------GARGPRLEVVADASFLTE------PVSCEVSNAV---GSANRSTAL 256
Query: 436 NVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESR 495
+V + ++ PE + G C A GNP P + W +R
Sbjct: 257 DVLFGP---ILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTW---------------TR 297
Query: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA-GQLS------ASTQLAVQFPPTNV 548
R G + GS + L V GP D + C+A LS A +L V PP V
Sbjct: 298 R---GGAQVLGSGATLRLPSV-GPED-AGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-V 351
Query: 549 TILANASALRPGDALNLTCVSVSSNPP--VNLSWDK 582
T L +A A G A L C+ +S P V SWD+
Sbjct: 352 TALHSAPAFLRGPA-RLQCLVFASPAPDAVVWSWDE 386
>gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo
sapiens]
Length = 1163
Score = 95.5 bits (236), Expect = 3e-19
Identities = 143/529 (27%), Positives = 204/529 (38%), Gaps = 95/529 (17%)
Query: 561 DALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQR 620
+ + L CV+ S P +++W G+ L +G ++ L++ + G
Sbjct: 152 EPVTLRCVARGSPLP-HVTWKLRGKDL---------GQGQGQVQVQNGTLRIRRVERGSS 201
Query: 621 --VTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVV-----TAVEQGEALLPVSVSAN 673
TC+A S E T ++ + LG V+VV T + L A
Sbjct: 202 GVYTCQASSTEGSATHATQLLV--------LGPPVIVVPPKNSTVNASQDVSLACHAEAY 253
Query: 674 PAPEAFNW------TFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGT 727
PA ++W F RL P R RIL G+L L D G Y C S G
Sbjct: 254 PANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYT--CVPSNGL 307
Query: 728 AE---ARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMF-NWERLGEDEE 783
A L V P + I C V ANP P +F +W + D +
Sbjct: 308 LHPPSASAYLTVLCMPGV----------------IRCPVRANP--PLLFVSWTK---DGK 346
Query: 784 DQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDN-----GVAPPARRLLRLVVRFAP 838
LD S+G G L I G Y C N G +P R LL+ F
Sbjct: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF-- 404
Query: 839 QVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGG 898
+E P K + + C A+G P V +WTK G L Q
Sbjct: 405 -IERP----KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQ-----------GQAQ 448
Query: 899 VHSSLLTIANVSAAQDYALFTCTATNALG--SDQTNIQLVSISRPDPPSGLKVVSLTPHS 956
V S+ I + + + C+A+NA+ + TN+ ++ S P + + VV+L P
Sbjct: 449 VDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS-PHVVTNVSVVAL-PKG 506
Query: 957 VGLEWKPGFDGGLPQRFCIRYEALG-TPGFHYVD----VVPPQATTFTLTGLQPSTRYRV 1011
+ W+PGFDGG QRF + Y L P + D VP A + GLQP T+Y+
Sbjct: 507 ANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQF 566
Query: 1012 WLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGL 1060
+LA N LG ++ P P G P ++P P S P GL
Sbjct: 567 SVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIP-PPLSPPRGL 614
Score = 48.9 bits (115), Expect = 3e-05
Identities = 114/514 (22%), Positives = 191/514 (37%), Gaps = 83/514 (16%)
Query: 256 RAGQSLELPC---VARGGNPLATLQWLKNG--QPVSTAWGTEHTQA----VAR------- 299
RAG+S+ L C G PL ++WL+ G P+ +G + V R
Sbjct: 32 RAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGA 91
Query: 300 SVLVMTVRPEDHG----AQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTEN- 354
S+ + +R ED G + H + L V PP + + +
Sbjct: 92 SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQEL 151
Query: 355 KNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLT 414
+ VTL CV++ S P + W L + L G G + + N T RR + G +
Sbjct: 152 EPVTLRCVARGS-PLPHVTWKLRGKDL---------GQGQGQVQVQNGTLRIRRVERGSS 201
Query: 415 --LTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNP 472
TC+A S + + L+L I PP+ + A V L C A
Sbjct: 202 GVYTCQASSTEGSATHATQLLVLGPPV------IVVPPKNSTVNASQDVSLACHAEAYPA 255
Query: 473 EPSLMWYKDSRTVTE-SRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAG 531
+ W++D+ V SRL R + GS+ +L T P D AG
Sbjct: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLR----------LLATQPDD--------AG 297
Query: 532 QLSASTQLAVQFPPT---NVTILANASALRPGDALNLTCVSVSSNPP-VNLSWDKEGERL 587
+ + PP+ +T+L +R V +NPP + +SW K+G+ L
Sbjct: 298 CYTCVPSNGLLHPPSASAYLTVLCMPGVIR---------CPVRANPPLLFVSWTKDGKAL 348
Query: 588 EGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPE 647
+ + P S+++ + + D +C +++ S R+ + P
Sbjct: 349 Q-----LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
Query: 648 FLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLW 707
F+ E L+P S +P P +WT G L + ++ S+ +L L
Sbjct: 404 FIERPKEEYFQEVGRELLIPCSAQGDP-PPVVSWTKVGRGLQ----GQAQVDSNSSLILR 458
Query: 708 NVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPT 741
+T+ G ++ C S A +V+ T
Sbjct: 459 PLTKEAHGHWE--CSASNAVARVATSTNVYVLGT 490
Score = 36.2 bits (82), Expect = 0.20
Identities = 68/312 (21%), Positives = 107/312 (34%), Gaps = 55/312 (17%)
Query: 38 PENLTVVEGASVELRCGV-STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
P L V E V LRC +P V W G LG +G L
Sbjct: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-----------QGQVQVQNGTL 191
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEY 156
I + Y CQ +E + ++L P ++++ P+ T+ A Q+
Sbjct: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLG----PPVIVVPPKNSTVN---ASQDV 244
Query: 157 VVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKL-----FTVEATARVTPRSSDN 211
+ C +A PA T S N+N +L V+ + R+ D+
Sbjct: 245 SLAC-HAEAYPA--------NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDD 295
Query: 212 RQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGN 271
C S+ L P AS + VL PG + C R
Sbjct: 296 AGCYTCVPSNGLLHPP-SASAYLTVLCMPGV--------------------IRCPVRANP 334
Query: 272 PLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHG 331
PL + W K+G+ + +Q S L++ + ED + SC +NS+
Sbjct: 335 PLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPV 393
Query: 332 ITLQVTFPPSAI 343
+ + PP+ I
Sbjct: 394 TRVLLKAPPAFI 405
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 94.0 bits (232), Expect = 8e-19
Identities = 138/633 (21%), Positives = 232/633 (36%), Gaps = 58/633 (9%)
Query: 202 ARVTPRSSDNRQLLVCEAS-SPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQS 260
AR P + L+C S A+E P+ S + PP I + V +
Sbjct: 2 ARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELT---QPPTITKQSAKDHIVDPRDN 58
Query: 261 LELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVR----PEDHGAQLS 316
+ + C A+G NP + W +N + + A + LV+ R PE++ +
Sbjct: 59 ILIECEAKG-NPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQ 117
Query: 317 CEAHNSVSAGTQEHGITLQVTFPPS-AIIILGSASQTENKNVTLSCVSKSSRPRVLLRWW 375
C A N I LQV+ P L E +TL C P ++ W
Sbjct: 118 CFARNKFGTALSNR-IRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 176
Query: 376 LGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEA---FSEAFTKETFKKS 432
+ + ++ V G H G + SN+ +D +C A F+ ++
Sbjct: 177 SSSMEPITQDKRVSQG-HNGDLYFSNVML----QDMQTDYSCNARFHFTHTIQQKNPFTL 231
Query: 433 LILNVKYPAQK----LWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTES 488
+L + A++ ++ +G Q + G + L C+A G P P + WYK +
Sbjct: 232 KVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA-SGVPTPDIAWYKKGGDLPSD 290
Query: 489 RLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTC----KAGQLSASTQLAVQFP 544
+ E+ F++ L + ++ ++ C K G + + + V+
Sbjct: 291 KAKFEN--------------FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
Query: 545 PTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAA 604
P + N L PG+ L C + NP + W GE L+ P R +
Sbjct: 337 PYWLDEPKNL-ILAPGEDGRLVC-RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII 394
Query: 605 ARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEA 664
R Q+SSR Q T H L S + P L + ++ +
Sbjct: 395 FRDT--QISSRAVYQCNTSNEHGYLLANAFVSVLDVP----PRMLSPRNQLIRVILYNRT 448
Query: 665 LLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNS 724
L +P P W G + GG H + +G+L + + + D G+Y N
Sbjct: 449 RLDCPFFGSPIP-TLRWFKNGQGSNLDGGNYH-VYENGSLEIKMIRKEDQGIYTCVATNI 506
Query: 725 EGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEED 784
G AE ++RL+V I + + G +V + C V +P L +W L +DE
Sbjct: 507 LGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW--LKDDEPL 564
Query: 785 QSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCI 817
+ M+K L I G+Y C+
Sbjct: 565 YIGNRMKK----EDDSLTIFGVAERDQGSYTCV 593
Score = 58.2 bits (139), Expect = 5e-08
Identities = 109/484 (22%), Positives = 177/484 (36%), Gaps = 52/484 (10%)
Query: 470 GNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCK 529
GNP PS W ++SR ++ P+ S R G++ + R P + + ++ C
Sbjct: 67 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGR-------PEEYEGEYQCF 119
Query: 530 AGQ-----LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEG 584
A LS +L V P + ++ G L L C P + W
Sbjct: 120 ARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 179
Query: 585 ERLEGVAAPPRRAP-FKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVL 643
+E + R + G +V+LQ D+ R H + + F L VL
Sbjct: 180 --MEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS--CNARFHFTHTIQQKNPF-TLKVL 234
Query: 644 YR-------PEFLGEQVLVVTA-VEQG-EALLPVSVSANPAPEAFNWTFRGYRLSPAGGP 694
P F+ Q + V +G + LL S P P+ W +G L P+
Sbjct: 235 TTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPD-IAWYKKGGDL-PSDKA 292
Query: 695 RHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVG 754
+ + AL + NV+ D G Y N G+ + + V AP L +P + +
Sbjct: 293 KFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW--LDEPKNLILA 349
Query: 755 GSVD--IVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAG 812
D +VC + NP W GE + + +++ G T + +++
Sbjct: 350 PGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVA-GDT--IIFRDTQISSRA 404
Query: 813 AYQCIVDNGVAPPARRLLRLVVRFAPQVEHP-TPLTKVAAAGDSTSSATLHCRARGVPNI 871
YQC N V+ P++ P L +V + L C G P
Sbjct: 405 VYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILY----NRTRLDCPFFGSPIP 460
Query: 872 VFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQT 931
W KNG +L Y H Y G + ++ +D ++TC ATN LG +
Sbjct: 461 TLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIR------KEDQGIYTCVATNILGKAEN 512
Query: 932 NIQL 935
++L
Sbjct: 513 QVRL 516
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 93.6 bits (231), Expect = 1e-18
Identities = 132/588 (22%), Positives = 212/588 (36%), Gaps = 72/588 (12%)
Query: 470 GNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCK 529
G P P++ WYK V + S R+ L SGS F +V ++ + C
Sbjct: 54 GRPTPTIEWYKGGERVETDKDDPRSHRMLL----PSGSLFFLRIVHGRKSRPDEGVYVCV 109
Query: 530 AGQL-------SASTQLAV-----QFPPTNVTILANASALRPGDALNLTCVSVSSNPPVN 577
A +AS ++A+ + P++V + A+ + C +P
Sbjct: 110 ARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV-------MECQPPRGHPEPT 162
Query: 578 LSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSF 637
+SW K+G L+ R +G + ++ D G+ V + RE S
Sbjct: 163 ISWKKDGSPLDD---KDERITIRGG---KLMITYTRKSDAGKYVCVGTNMVGERE--SEV 214
Query: 638 YRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHR 697
L VL RP F+ + V+ A +P P W L + R+
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDS-AEFKCEARGDPVPTV-RWRKDDGELPKS---RYE 269
Query: 698 ILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSV 757
I L + VT D G Y +N G AEA L V P V +G +V
Sbjct: 270 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV 329
Query: 758 DIVCTVDANPILPGMFNWERLGEDE---EDQSLDDMEKISRGPTGRLRIHHAKLAQAGAY 814
C NP P +F W R G Q + S TG L I + + + G Y
Sbjct: 330 TFQCEATGNP-QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 387
Query: 815 QC----IVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPN 870
C + + + + ++ P V P+ + A + L C A G P
Sbjct: 388 ICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV---DGTFVLSCVATGSPV 444
Query: 871 IVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQ 930
W K+GV + QD R + + + +L I + D +TC A+ G
Sbjct: 445 PTILWRKDGVLVSTQDSRIKQ-------LENGVLQI-RYAKLGDTGRYTCIASTPSGEAT 496
Query: 931 TNIQL------VSISRPDP---------PSGLKVVSLTPHSVGLEWKPGFD-GGLPQRFC 974
+ + V + P P PS +V ++ ++V L W+P + G P +
Sbjct: 497 WSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYI 556
Query: 975 IRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDS 1022
I + + + T + GL+P+ Y + A+NA G S
Sbjct: 557 IEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGIS 604
Score = 59.3 bits (142), Expect = 2e-08
Identities = 118/539 (21%), Positives = 193/539 (35%), Gaps = 75/539 (13%)
Query: 335 QVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDG--L 392
Q FPP + ++ + TL+C ++ RP + W+ G ++ ET D
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERV----ETDKDDPRS 78
Query: 393 HGGHISMSNLTFLA------RREDNGLTLTCEA---FSEAFTKETFKKSLILNVKYPAQK 443
H + +L FL R D G+ + C A EA + + IL +
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYV-CVARNYLGEAVSHNASLEVAILRDDFRQN- 136
Query: 444 LWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVE 503
P + G + C G+PEP++ W KD S L + R+ +
Sbjct: 137 ------PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG-----SPLDDKDERITIRG-- 183
Query: 504 KSGSTFSRELVLVTGPSDNQAKFTCKAGQL-----SASTQLAVQFPPTNVTILANASALR 558
+ ++ T SD K+ C + S +L V P+ V +N A+
Sbjct: 184 ------GKLMITYTRKSD-AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNL-AVT 235
Query: 559 PGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHG 618
D+ C +P + W K+ L P R + + + +V++ D G
Sbjct: 236 VDDSAEFKC-EARGDPVPTVRWRKDDGEL-----PKSRYEIRDDHTLK--IRKVTAGDMG 287
Query: 619 QRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEA 678
TC A + + S+ L V P F+ + V A+ + + NP P
Sbjct: 288 S-YTCVAENMVGKAEASA--TLTVQEPPHFVVKPRDQVVALGR-TVTFQCEATGNPQPAI 343
Query: 679 FNWTFRGYR------LSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARL 732
F W G + P R + +G L + NV R+D G Y N G+ +
Sbjct: 344 F-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKA 402
Query: 733 RLDV------HYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQS 786
L+V P IR V V G+ + C +P+ ++ + + +D
Sbjct: 403 YLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSR 462
Query: 787 LDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTP 845
+ +E G L+I +AKL G Y CI V F V+ P P
Sbjct: 463 IKQLE------NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRP 515
Score = 48.9 bits (115), Expect = 3e-05
Identities = 78/344 (22%), Positives = 128/344 (37%), Gaps = 37/344 (10%)
Query: 38 PENLTVVEGASVELRCGV-STPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHL 96
P NL V S E +C P V+W KD D +P RY + D L
Sbjct: 229 PSNLAVTVDDSAEFKCEARGDPVPTVRWRKD------DGELPK-SRYEIRDDHT-----L 276
Query: 97 HIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEY 156
I D Y C V + +G S L++ PP ++ + + G+
Sbjct: 277 KIRKVTAGDMGSYTC-VAENMVGKAEAS--ATLTVQEPPHFVVKPRDQVVAL----GRTV 329
Query: 157 VVNC-VSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQL- 214
C +G+ +PA I + ++ + F+V T +T + +
Sbjct: 330 TFQCEATGNPQPA----IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 385
Query: 215 -LVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPL 273
+C+ + A KA V + PP + G V + L CVA G +P+
Sbjct: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG-SPV 444
Query: 274 ATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSC-------EAHNSVSAG 326
T+ W K+G VST + + VL + + +C EA S
Sbjct: 445 PTILWRKDGVLVSTQ--DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 502
Query: 327 TQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRV 370
QE G+ +Q P +I + S+ E +V+ + V+ S +P +
Sbjct: 503 VQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 546
Score = 40.0 bits (92), Expect = 0.014
Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 836 FAPQ-VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNG--VPLDLQDPRYTEH 892
F P+ VEHP+ L + + G+ ATL+C+A G P W K G V D DPR
Sbjct: 27 FPPRIVEHPSDL--IVSKGEP---ATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81
Query: 893 TYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG 927
G + L + + D ++ C A N LG
Sbjct: 82 LLPSGSLF-FLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sapiens]
Length = 761
Score = 93.6 bits (231), Expect = 1e-18
Identities = 132/643 (20%), Positives = 230/643 (35%), Gaps = 52/643 (8%)
Query: 441 AQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLG 500
A L ++ P ++ G +C G + + W+ + +L +R+ +
Sbjct: 17 AVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNG----EKLTPNQQRISVV 72
Query: 501 SVEKSGSTFSRELVLVTGPSDNQAKFTCKA-GQLSASTQLAVQFPPTNVTILANASA--- 556
+ S ST L + D+ + C G+ + ++ V + NA
Sbjct: 73 WNDDSSST----LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQE 128
Query: 557 LRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRD 616
R G+ + C VSS PP + W +G + + F + + + D
Sbjct: 129 FREGEDAVIVCDVVSSLPPT-IIWKHKGRDV----ILKKDVRFIVLSNNYLQIRGIKKTD 183
Query: 617 HGQRVTCRAHSAELRETVSSFYRLNVLYR--PEFLGEQVLVVTAVEQGEALLPVSVSANP 674
G T R L +F + V+ P Q +V G+++ V +
Sbjct: 184 EG---TYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 675 APEAFNWTFRGYRLSPAGGPRHRILS--SGALHLWNVTRADDGLYQLHCQNSEGTAEARL 732
+WT G ++ I S S L + V + D+ Y +N G +A +
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
Query: 733 RLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLD-DME 791
L V P I +++ T + + V + C +PI + E+++LD M
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
Query: 792 KISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAA 851
S L + + AG Y C N + ++ + L V++AP+++ P VA
Sbjct: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY-LEVQYAPKLQGP-----VAV 414
Query: 852 AGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSA 911
+ + C P+ +W ++G L P S+ +
Sbjct: 415 YTWEGNQVNITCEVFAYPSATISWFRDGQLL----PSSNYSNIKIYNTPSASYLEVTPDS 470
Query: 912 AQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEW---KPGFDGG 968
D+ + CTA N +G + LV P PS + + P+S + +P GG
Sbjct: 471 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS---IDQVEPYSSTAQVQFDEPEATGG 527
Query: 969 LP-QRFCIRYEALGTPGFH---YVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGL 1024
+P ++ + A+G +H Y T+ GL+P T Y V L A N GL
Sbjct: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNG---KGL 584
Query: 1025 ADKGTQLPITTPGLHQP----SGEPEDQLPTEPPSGPSGLPLL 1063
+ T +H P S +P PP LP L
Sbjct: 585 GEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPAL 627
Score = 41.6 bits (96), Expect = 0.005
Identities = 74/317 (23%), Positives = 122/317 (38%), Gaps = 45/317 (14%)
Query: 40 NLTVVEGASVELRCGVST-PGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHI 98
N T G SV L C P + W KDG + + +Y D ++ L I
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE---DDEKYIFSDDSSQ----LTI 274
Query: 99 EACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVV 158
+ D +D+AEY C + ++ G + + L + PK+ + + + ++ +
Sbjct: 275 KKVDKNDEAEYIC-IAENKAGEQ--DATIHLKVFAKPKITYVENQTAMELE----EQVTL 327
Query: 159 NC-VSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLL-- 215
C SGD P P IT S + IS E + V + ARV+ + + Q
Sbjct: 328 TCEASGD--PIPSITWRTSTRNISS-----EEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
Query: 216 ---VCEASSPALEAPIKASFTVNVLFPP---GPPVIEWPGLDEGHVRAGQSLELPCVARG 269
+C AS+ + S + V + P GP + + G + + C
Sbjct: 381 GEYICTASNTIGQD--SQSMYLEVQYAPKLQGPVAV--------YTWEGNQVNITCEVFA 430
Query: 270 GNPLATLQWLKNGQ--PVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGT 327
P AT+ W ++GQ P S + + S L +T E+ +C A N + +
Sbjct: 431 -YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
Query: 328 QEHGITLQVTFPPSAII 344
E I +Q P S I
Sbjct: 490 LEF-ILVQADTPSSPSI 505
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,704,329
Number of Sequences: 37866
Number of extensions: 2820818
Number of successful extensions: 13752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 295
Number of HSP's that attempted gapping in prelim test: 8607
Number of HSP's gapped (non-prelim): 3377
length of query: 1241
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1127
effective length of database: 13,930,794
effective search space: 15700004838
effective search space used: 15700004838
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.