Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4758274
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758274 erythrocyte membrane protein band 4.1
(elliptocytosis 1, RH-linked) isoform 3 [Homo sapiens]
(588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 1179 0.0
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 1150 0.0
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 1017 0.0
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 622 e-178
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 536 e-152
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 536 e-152
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 531 e-151
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 525 e-149
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 525 e-149
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 299 4e-81
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 274 1e-73
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 261 1e-69
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 258 1e-68
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 258 1e-68
gi|117500790 FERM domain containing 3 [Homo sapiens] 257 2e-68
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 253 3e-67
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 245 7e-65
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 243 4e-64
gi|34916000 FERM domain containing 7 [Homo sapiens] 234 2e-61
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 222 7e-58
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 222 9e-58
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 157 2e-38
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 156 4e-38
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 156 6e-38
gi|161702986 ezrin [Homo sapiens] 152 1e-36
gi|21614499 ezrin [Homo sapiens] 152 1e-36
gi|4505257 moesin [Homo sapiens] 139 7e-33
gi|4506467 radixin [Homo sapiens] 137 4e-32
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 132 9e-31
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 132 9e-31
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 1179 bits (3050), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIR 420
AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIR
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIR 420
Query: 421 HSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ 480
HSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ
Sbjct: 421 HSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ 480
Query: 481 IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRI 540
IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRI
Sbjct: 481 IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRI 540
Query: 541 EKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
EKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Sbjct: 541 EKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 1150 bits (2975), Expect = 0.0
Identities = 588/641 (91%), Positives = 588/641 (91%), Gaps = 53/641 (8%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK-------------- 406
AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420
Query: 407 -----KKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 461
KKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE
Sbjct: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 480
Query: 462 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 521
WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK
Sbjct: 481 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 540
Query: 522 TITYEAAQT----------------------------------VKGGISETRIEKRIVIT 547
TITYEAAQT VKGGISETRIEKRIVIT
Sbjct: 541 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 600
Query: 548 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Sbjct: 601 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 1017 bits (2630), Expect = 0.0
Identities = 532/622 (85%), Positives = 532/622 (85%), Gaps = 90/622 (14%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
MHCKVSLLDDTVYECVVE TWLDSAK
Sbjct: 210 MHCKVSLLDDTVYECVVE-----------------------------------TWLDSAK 234
Query: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 235 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 474
Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 475 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 534
Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIR 420
AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK
Sbjct: 535 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK-------------- 580
Query: 421 HSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ 480
DLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ
Sbjct: 581 -------DLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ 633
Query: 481 IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQT---------- 530
IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQT
Sbjct: 634 IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPG 693
Query: 531 ------------------------VKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAK 566
VKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAK
Sbjct: 694 VLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAK 753
Query: 567 EQHPDMSVTKVVVHQETEIADE 588
EQHPDMSVTKVVVHQETEIADE
Sbjct: 754 EQHPDMSVTKVVVHQETEIADE 775
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 622 bits (1603), Expect = e-178
Identities = 327/553 (59%), Positives = 395/553 (71%), Gaps = 57/553 (10%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
+ CKV+LLD T Y C +EKHAKGQ L +VCEHLNLLE+DYFGL ++ K WLD AK
Sbjct: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
Query: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SYT+Q+ELGDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRY
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517
Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+
Sbjct: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577
Query: 357 -QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGE 415
G V+ V D ++ V P +A KK R++G+
Sbjct: 578 GPGLVSIAVVQDGDGRREV-----------------RSPTKAPHLQLIEGKKNSLRVEGD 620
Query: 416 NIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLST------- 468
NIY+RHSNLMLE+LDK+QE+I KH ASISELK+NFMES PEPRP+EW+KR T
Sbjct: 621 NIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQ 680
Query: 469 HSPFRTLNI--------------------NG-QIPTGEGP-------PLVKTQTVTISDN 500
S TLNI NG +I G GP P+ + + ++S
Sbjct: 681 GSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSE 740
Query: 501 ANAVKSEIPTKDV 513
+++ SE +DV
Sbjct: 741 SSSSSSESEEEDV 753
Score = 139 bits (351), Expect = 6e-33
Identities = 80/147 (54%), Positives = 96/147 (65%), Gaps = 35/147 (23%)
Query: 475 LNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQ----- 529
+++ QI PP+VKT+ VTISD + ++EI TK+VPIV TETKTITYE+ Q
Sbjct: 858 IDVLPQIICCSEPPVVKTEMVTISDASQ--RTEISTKEVPIVQTETKTITYESPQIDGGA 915
Query: 530 ----------------------------TVKGGISETRIEKRIVITGDADIDHDQVLVQA 561
TVKGGISETRIEKRIVITGD DIDHDQ L QA
Sbjct: 916 GGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGDIDHDQALAQA 975
Query: 562 IKEAKEQHPDMSVTKVVVHQETEIADE 588
I+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 976 IREAREQHPDMSVTRVVVHKETELAEE 1002
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 536 bits (1380), Expect = e-152
Identities = 263/379 (69%), Positives = 310/379 (81%), Gaps = 5/379 (1%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
+ CKV+LLD T Y C +EKHAKGQ L +VCEHLNLLE+DYFGL ++ K WLD AK
Sbjct: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
Query: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SYT+Q+ELGDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRY
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517
Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+
Sbjct: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577
Query: 357 -QGQVAEGGVLDASAKKTV 374
G V+ V D ++ V
Sbjct: 578 GPGLVSIAVVQDGDGRREV 596
Score = 110 bits (276), Expect = 3e-24
Identities = 63/103 (61%), Positives = 71/103 (68%), Gaps = 10/103 (9%)
Query: 486 GPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIV 545
GP LV V D V+S PTK + E KT VKGGISETRIEKRIV
Sbjct: 578 GPGLVSIAVVQDGDGRREVRS--PTKAPHLQLIEGKT--------VKGGISETRIEKRIV 627
Query: 546 ITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
ITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 628 ITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 536 bits (1380), Expect = e-152
Identities = 263/379 (69%), Positives = 310/379 (81%), Gaps = 5/379 (1%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
+ CKV+LLD T Y C +EKHAKGQ L +VCEHLNLLE+DYFGL ++ K WLD AK
Sbjct: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
Query: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SYT+Q+ELGDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRY
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517
Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+
Sbjct: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577
Query: 357 -QGQVAEGGVLDASAKKTV 374
G V+ V D ++ V
Sbjct: 578 GPGLVSIAVVQDGDGRREV 596
Score = 110 bits (276), Expect = 3e-24
Identities = 63/103 (61%), Positives = 71/103 (68%), Gaps = 10/103 (9%)
Query: 486 GPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIV 545
GP LV V D V+S PTK + E KT VKGGISETRIEKRIV
Sbjct: 578 GPGLVSIAVVQDGDGRREVRS--PTKAPHLQLIEGKT--------VKGGISETRIEKRIV 627
Query: 546 ITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
ITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 628 ITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 531 bits (1369), Expect = e-151
Identities = 283/491 (57%), Positives = 344/491 (70%), Gaps = 43/491 (8%)
Query: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
C+V+LLD + YEC VEKH +GQ L VCEHLNLLE+DYFGL D + K WLD +KEI
Sbjct: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
Query: 63 KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
KKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 159 KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218
Query: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
+Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278
Query: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338
Query: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRYSG
Sbjct: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 397
Query: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
RTQAQTRQASALIDRPAP FER++SKR SRSLDGA A S + P
Sbjct: 398 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGP------- 450
Query: 361 AEGGVLDASAKK-TVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYI 419
+G D + +A++ V+ K ++ PEQ E P
Sbjct: 451 -DGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQ-ETTP------------------ 490
Query: 420 RHSNLMLEDLDKSQEEIKKHHASISELKKNFME--SVPEPRPSEWDKRLSTHSPFRTLNI 477
RH E LDK ++ + KH ASI+ELK+ E S R +W++ R L
Sbjct: 491 RHKQ---EFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERE-------RRLPS 540
Query: 478 NGQIPTGEGPP 488
+ P+ +G P
Sbjct: 541 SPASPSPKGTP 551
Score = 89.0 bits (219), Expect = 1e-17
Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 2/103 (1%)
Query: 486 GPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIV 545
GP V T+ ++S K + + T + + T +TVKGG SETRIEKRI+
Sbjct: 772 GPQTVATEIRSLSPIIG--KDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRII 829
Query: 546 ITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
ITGD D+D DQ L AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 830 ITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 872
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 525 bits (1352), Expect = e-149
Identities = 266/401 (66%), Positives = 313/401 (78%), Gaps = 19/401 (4%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
M CKV LLD + Y C VEK ++GQ L +VCEHLNLLE+DYFGL D K WLD AK
Sbjct: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169
Query: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
EIKKQVR W+F+FNVKFYPPDPAQL+EDITRYYLCLQLR DIV+GRLPCSF TLALLG
Sbjct: 170 EIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLG 229
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SYT+QSELGDYDP+ G DY+S+F+ APN TKELE+KV+ELHKS+R MTPA+A++ FLEN
Sbjct: 230 SYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLEN 289
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
AKKLSMYGVDLH AKD EGV+I+LGVC+SGLL+Y+D+LRINRF WPKVLKISYKR++F+I
Sbjct: 290 AKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYI 349
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
KIRPGE EQ+ESTIGFKLP++RAAK+LWKVCVEHHTFFRL + PK KFL LGSKFRY
Sbjct: 350 KIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRY 408
Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQG 358
SGRTQAQTR+ASALIDRPAP+FER++SKR SRSLDG T A T+
Sbjct: 409 SGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVG----------TGQYATTK- 457
Query: 359 QVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEP 399
G+ + TV P+ + E + E + + E+ P
Sbjct: 458 -----GISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTP 493
Score = 137 bits (346), Expect = 2e-32
Identities = 79/133 (59%), Positives = 88/133 (66%), Gaps = 34/133 (25%)
Query: 490 VKTQTVTI-SDNANAVKSEIPTKDVPIVHTETKTITYEAAQ------------------- 529
VKT+T++ S + VK EI TK+VP+VHTETKTITYE++Q
Sbjct: 951 VKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTIT 1010
Query: 530 --------------TVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVT 575
TVKGGISETRIEKRIVITGDADIDHDQ L QAIKEAKEQHPDMSVT
Sbjct: 1011 SETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVT 1070
Query: 576 KVVVHQETEIADE 588
KVVVH+ETEI E
Sbjct: 1071 KVVVHKETEITPE 1083
Score = 53.9 bits (128), Expect = 4e-07
Identities = 59/214 (27%), Positives = 92/214 (42%), Gaps = 23/214 (10%)
Query: 376 PKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEE 435
PKA + + D E+ + E T+ E E+ + L ++L+K+Q++
Sbjct: 669 PKAASLSASLDNDPSDSSEEETDSERTDT-AADGETTATESDQEEDAELKAQELEKTQDD 727
Query: 436 IKKHHASISELKKNFME-SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQT 494
+ KH +ISELK+ F+E S +EW+KRLST SP R P E PLV +T
Sbjct: 728 LMKHQTNISELKRTFLETSTDTAVTNEWEKRLST-SPVRLAARQEDAPMIE--PLVPEET 784
Query: 495 VTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDH 554
S SEI ++ + K + T S++ ++K T + I+
Sbjct: 785 KQSSGEKLMDGSEI----FSLLESARKPTEFIGGVT---STSQSWVQKMETKTESSGIE- 836
Query: 555 DQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
E H +S KVV QET + +E
Sbjct: 837 --------TEPTVHHLPLSTEKVV--QETVLVEE 860
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 525 bits (1352), Expect = e-149
Identities = 278/490 (56%), Positives = 334/490 (68%), Gaps = 53/490 (10%)
Query: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
C+V+LLD + YEC VEKH +GQ L VCEHLNLLE+DYFGL D + K WLD +KEI
Sbjct: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
Query: 63 KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
KKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 97 KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156
Query: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
+Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216
Query: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276
Query: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRYSG
Sbjct: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 335
Query: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
RTQAQTRQASALIDRPAP FER++SKR SRSLDGA RP S
Sbjct: 336 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGA-------EFSRPAS--------- 379
Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIR 420
S P K E + E+ E K+
Sbjct: 380 -------VSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE------------- 419
Query: 421 HSNLMLEDLDKSQEEIKKHHASISELKKNFME--SVPEPRPSEWDKRLSTHSPFRTLNIN 478
L+ LDK ++ + KH ASI+ELK+ E S R +W++ R L +
Sbjct: 420 -----LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERE-------RRLPSS 467
Query: 479 GQIPTGEGPP 488
P+ +G P
Sbjct: 468 PASPSPKGTP 477
Score = 89.4 bits (220), Expect = 9e-18
Identities = 64/158 (40%), Positives = 84/158 (53%), Gaps = 9/158 (5%)
Query: 434 EEIKKHHASISEL---KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLV 490
E +K ++S L KK E+V + R S D +S IP GP V
Sbjct: 619 EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNT-QENSLKSGKGAAAMIP---GPQTV 674
Query: 491 KTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDA 550
T+ ++S K + + T + + T +TVKGG SETRIEKRI+ITGD
Sbjct: 675 ATEIRSLSPIIG--KDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDE 732
Query: 551 DIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
D+D DQ L AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 733 DVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 770
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 299 bits (766), Expect = 4e-81
Identities = 154/338 (45%), Positives = 218/338 (64%), Gaps = 7/338 (2%)
Query: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKT-WLDSAKE 61
C + LLD+TV V KH +GQ LL V +HL+L E+DYFGL + D++T WLD K
Sbjct: 31 CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKP 90
Query: 62 IKKQV-RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
I+KQ+ RG P++ F VKF+ DP +L E+ TRY LQ++QDI+ GRLPC T ALL
Sbjct: 91 IRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLA 150
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
S+ +QSELGDYD + Y+SD+ PNQ ++ E+++ +LH+ + ++PA+A+ +L
Sbjct: 151 SFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNT 210
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
A+ L +YGV+ H A+D +I++GV S G+L+YK+++R+N FPW K++KIS+K FFI
Sbjct: 211 ARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFI 270
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLA----LGS 296
++R E E+ +GF + +YRA K LWK CVEHHTFFRL P+ F A LGS
Sbjct: 271 QLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGS 329
Query: 297 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSL 334
KFRY GRT+ Q+ Q F R+ SK +R L
Sbjct: 330 KFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKL 367
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 274 bits (701), Expect = 1e-73
Identities = 146/335 (43%), Positives = 204/335 (60%), Gaps = 7/335 (2%)
Query: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
C+VSLLD T + K AKGQ+L ++ HL+L+E DYFGL D+A WLD K I
Sbjct: 45 CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSI 104
Query: 63 KKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
KKQV+ G P+ VKFY +P L E++TRY LQL+QDI++G+L C F T L +
Sbjct: 105 KKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAA 164
Query: 122 YTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENA 181
Y +Q+ELGDYD H + VS+F+ P QT+E+E + E K YR TPAQA+ +L A
Sbjct: 165 YNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKA 224
Query: 182 KKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIK 241
K L MYGVD+H K +G D LG+ +G+LV++ +I F WPK+ ++ +K++ +
Sbjct: 225 KWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLV 284
Query: 242 IRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALGSK 297
+ + + + E T F+L +A K LWK VEHH FFRL + +S F+ LGS+
Sbjct: 285 VVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSR 344
Query: 298 FRYSGRTQAQTRQASALIDRPAPHFERTASKRASR 332
FRYSG+T+ QT + + R + FER SKR SR
Sbjct: 345 FRYSGKTEYQTTKTNKA--RRSTSFERRPSKRYSR 377
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 261 bits (667), Expect = 1e-69
Identities = 150/362 (41%), Positives = 208/362 (57%), Gaps = 5/362 (1%)
Query: 4 KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIK 63
K+ +LDDT V + A G+ LL VC HLNL+E DYFGL D+ WLD K I
Sbjct: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102
Query: 64 KQVRGVPWNFT-FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
KQ+R F VKF+PPD QL E++TRY LQ++QD+ GRL C+ + ALL S+
Sbjct: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162
Query: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
+QSE+GD+D L ++++ K P Q LE+K++E H ++ TPA++D + LE A+
Sbjct: 163 IVQSEIGDFDEALDR-EHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQLLEIAR 220
Query: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
+L MYG+ LH AKD EG I L V ++G+LV++ +IN F W KV K+S+KR F IK+
Sbjct: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKL 280
Query: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL-TSTDTIPKSKFLALGSKFRYS 301
RP Y+ T+ F + S K WK+CVEHH FFRL PK + GS FR+S
Sbjct: 281 RPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFS 340
Query: 302 GRTQAQTRQASALIDRPAPHFERTASK-RASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
GRTQ Q FER SK + RSL +++ + + ++T G+
Sbjct: 341 GRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEG 400
Query: 361 AE 362
AE
Sbjct: 401 AE 402
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 258 bits (658), Expect = 1e-68
Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
++C+V LLD T + KHAKGQDL ++ HL+L+E DYFGL D+A WLD AK
Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
Query: 61 EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
+ +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +PAQA+L +L
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
Query: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K+ +K+S
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324
Query: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295
+ + + + + E T F+L S R K LWK VEHH FFRL + +S F+ LG
Sbjct: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384
Query: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329
S+FR+SGRT+ Q S L R FER SKR
Sbjct: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 258 bits (658), Expect = 1e-68
Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
++C+V LLD T + KHAKGQDL ++ HL+L+E DYFGL D+A WLD AK
Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
Query: 61 EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
+ +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +PAQA+L +L
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
Query: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K+ +K+S
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324
Query: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295
+ + + + + E T F+L S R K LWK VEHH FFRL + +S F+ LG
Sbjct: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384
Query: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329
S+FR+SGRT+ Q S L R FER SKR
Sbjct: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 257 bits (657), Expect = 2e-68
Identities = 155/470 (32%), Positives = 250/470 (53%), Gaps = 20/470 (4%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
M C + LLDD+ C +++ KGQ L+ +C + +LLE+DYFG+ D + WL+ K
Sbjct: 32 MRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNK 91
Query: 61 EIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
I KQ++ P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL CSF+ A L
Sbjct: 92 SIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYL 151
Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS-YRSMTPAQADLEFL 178
G+ +Q+ELGDYDP+ H +Y+S+F++ P Q+++LE K++E+HK+ R +P A+ L
Sbjct: 152 GACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLL 211
Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238
A L YGVD H KD G LG ++G +V++ RI+ WP V K+ ++ +F
Sbjct: 212 LKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTF 271
Query: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALG 295
++ G Q++ ++ + F + A K LWK VE+ F++ + T+ SK G
Sbjct: 272 YV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKG 328
Query: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAP 353
S+FRYSG+ + +AS+ I R P R R+S SL+ ++ P S P
Sbjct: 329 SRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPS-P 387
Query: 354 AITQGQVAEG-GVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERL 412
+ + ++ G GV + P VKA + ED P E+ + K K E L
Sbjct: 388 SEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEED-------KIKEEPL 440
Query: 413 D-GENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 461
E +Y ++L+ +D + ++ S EL++ +S + E
Sbjct: 441 TISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDTDSFEDLEADE 490
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 253 bits (647), Expect = 3e-67
Identities = 152/409 (37%), Positives = 222/409 (54%), Gaps = 28/409 (6%)
Query: 2 HCKVSLLDD-----TVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWL 56
+C+V LLD+ T + ++K KG +L V H+NL+E DYFGL D + WL
Sbjct: 12 YCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWL 71
Query: 57 DSAKEIKKQVR----GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCS 112
D AK + + G P+ F +KFY DP +L E+ITRY LQ++QD++ GRLPC
Sbjct: 72 DPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCP 131
Query: 113 FATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQ 172
T A LG+Y IQSELGDYDP H YVS+++ P+Q +ELEE + +HK+ P++
Sbjct: 132 VNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSE 191
Query: 173 ADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKIS 232
A+L +L AK L MYGVDLH + LG+ G++VYK+K ++ ++ WP++ K+
Sbjct: 192 AELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVH 251
Query: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD----TIPK 288
+K + F ++R ++ E++ F+ S A K LWK VEHHTFFR+ + +
Sbjct: 252 FKETQF--ELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKL 309
Query: 289 SKFLALGSKFRYSGRTQAQ-TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
SKF ++ K RYSGRT Q +R S + RP + R+ SK + + +S
Sbjct: 310 SKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAES----- 364
Query: 348 RPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQ 396
S IT E G + + K + P K KA K E+ P Q
Sbjct: 365 --NSISRITANM--ENGENEGTI-KIIAPSPVKSFKKA--KNENSPDTQ 406
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 245 bits (626), Expect = 7e-65
Identities = 133/363 (36%), Positives = 202/363 (55%), Gaps = 9/363 (2%)
Query: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
C V LLDD+ Y C +++ AKGQ L +C HLNLLE+DYFG+ D + WL+ K +
Sbjct: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
Query: 63 KKQVRGVP-WNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
KQ+R P + F VKFYP DPA L E+ITRY + LQ+++D+ GRL C + ALL +
Sbjct: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
Query: 122 YTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRS-MTPAQADLEFLEN 180
Y +Q+E+GDYD H Y S F+ P +++LE K+ E+HK+ S TPA ++L FL
Sbjct: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
A+ L YGVD H KD+ G L G +V + R++ W +V K+ ++ +F++
Sbjct: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALGSK 297
+ ++E+ + + + P+ A K LWK +E+ F++L + T+ S GS+
Sbjct: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316
Query: 298 FRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAPAI 355
FRYSGR + ++SA I R P R R+ S+ + S R+ R +I
Sbjct: 317 FRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISI 376
Query: 356 TQG 358
+G
Sbjct: 377 MEG 379
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 243 bits (620), Expect = 4e-64
Identities = 137/311 (44%), Positives = 187/311 (60%), Gaps = 8/311 (2%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
+H +V LLD+T+ +E GQ LL +V + LNL+E DYFG+ + + WL+ K
Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
Query: 61 EIKKQVRGVPWNFTFN--VKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLAL 118
I +Q+R P N VKF+PPDP QL E+ TRY LQL++D++ RL C+ T AL
Sbjct: 104 PIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAAL 162
Query: 119 LGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFL 178
L S+ +QSE+GDYD L +++ + P Q LE K++E H+ + TPA++D + L
Sbjct: 163 LTSHLLQSEIGDYDETLDR-EHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220
Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238
E A+KL MYG+ H A D EG I L V G+LV++ +IN F W KV K+S+KR F
Sbjct: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280
Query: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK--FLALGS 296
IK+ P Y+ T+ F L S K WK+CVE+HTFFRL PK+K F + GS
Sbjct: 281 LIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPK-PKAKAVFFSRGS 339
Query: 297 KFRYSGRTQAQ 307
FRYSGRTQ Q
Sbjct: 340 SFRYSGRTQKQ 350
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 234 bits (597), Expect = 2e-61
Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%)
Query: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
+H KV LDD+ VV++ + G+ L C HLNL E++YFGL ++ + WL+ K
Sbjct: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
Query: 61 EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+
Sbjct: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+
Sbjct: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
Query: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F
Sbjct: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
Query: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298
IK+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS F
Sbjct: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
Query: 299 RYSGRTQAQ 307
RYSGRTQ Q
Sbjct: 300 RYSGRTQRQ 308
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 222 bits (566), Expect = 7e-58
Identities = 123/353 (34%), Positives = 195/353 (55%), Gaps = 7/353 (1%)
Query: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT-SKTWLDSAKE 61
C + LD V V K GQ LL V HL + E++YFGL D++ S WL+++K
Sbjct: 31 CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA 90
Query: 62 IKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
I+KQ++G P F V+F+ PDP L ++ TR+ LQL+ DI GRL C + +L
Sbjct: 91 IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLA 150
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SY +QS GDY+ +H Y+SD P+Q ++ KV LH+ + + ++A+ ++
Sbjct: 151 SYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINI 210
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + + +PW +LKIS+KR FFI
Sbjct: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFI 270
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSKFLALGSK 297
R + E E + F + +YR+ K LWK CVEHHTFF +L + S++ +GS+
Sbjct: 271 HQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSR 330
Query: 298 -FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSAD-RSPR 348
+ S Q + ++ PA + ++SL + + + RSPR
Sbjct: 331 NTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPR 383
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 222 bits (565), Expect = 9e-58
Identities = 113/300 (37%), Positives = 175/300 (58%), Gaps = 5/300 (1%)
Query: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT-SKTWLDSAKE 61
C + LD V V K GQ LL V HL + E++YFGL D++ S WL+++K
Sbjct: 31 CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA 90
Query: 62 IKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
I+KQ++G P F V+F+ PDP L ++ TR+ LQL+ DI GRL C + +L
Sbjct: 91 IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLA 150
Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
SY +QS GDY+ +H Y+SD P+Q ++ KV LH+ + + ++A+ ++
Sbjct: 151 SYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINI 210
Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + + +PW +LKIS+KR FFI
Sbjct: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFI 270
Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSKFLALGSK 297
R + E E + F + +YR+ K LWK CVEHHTFF +L + S++ +GS+
Sbjct: 271 HQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSR 330
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 157 bits (398), Expect = 2e-38
Identities = 143/551 (25%), Positives = 239/551 (43%), Gaps = 76/551 (13%)
Query: 4 KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIK 63
++ LL++ E + + GQ+ L+ V + L L E YF L ++ + W+D K +K
Sbjct: 26 RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLK 85
Query: 64 KQVRGVPWNFT--FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
KQ+ T F V FY P +QL ++ITRY LQL++DI+ G +PC+ L
Sbjct: 86 KQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAG 145
Query: 122 YTIQSELGDYDPELHGVDYVSDFKLAP----NQTKELEE---KVMELHKSYRSMTPAQAD 174
+Q++ GD+D + D++ F L P K LEE KV LH+ YR +T A+
Sbjct: 146 LAVQADFGDFD-QYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAE 204
Query: 175 LEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLV-YKDKLRINRFPWPKVLKISY 233
+ +++ +++ YG + + AKD +G DI +G C G+ V +K+ F W + +S+
Sbjct: 205 MLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSH 264
Query: 234 KRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL------TSTDTI- 286
+S F + E E TI F+ AK +W++CV H F+RL T T T+
Sbjct: 265 NKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVN 319
Query: 287 --------------PKSKFLALGSKFRYSGR--TQAQTRQASALIDRPAPHF--ERTASK 328
P+ + + Y+G + Q + + ++ +T+
Sbjct: 320 PIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDNLFVPNQNGYYCHSQTSLD 379
Query: 329 RASRSLDG--------AAAVDSADRSPRP-------TSAPAITQGQVAEGGVLDASAKKT 373
RA L+G +A ++ +P+P +S P+IT V L +
Sbjct: 380 RAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPSITGSDVMRPDYLPSHRHSA 439
Query: 374 VVPKAQKETVKAE--VKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDK 431
V+P + + T E +K+ + AE ++ L NI ++ L
Sbjct: 440 VIPPSYRPTPDYETVMKQLNRGLVHAE--------RQSHSLRNLNIGSSYAYSRPAALVY 491
Query: 432 SQEEIKKH---------HASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP 482
SQ EI++H H S L +F P P P+E + S N Q
Sbjct: 492 SQPEIREHAQLPSPAAAHCPFS-LSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQ 550
Query: 483 TGEGPPLVKTQ 493
P +++TQ
Sbjct: 551 DYPSPNIMRTQ 561
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 156 bits (395), Expect = 4e-38
Identities = 83/251 (33%), Positives = 137/251 (54%), Gaps = 5/251 (1%)
Query: 103 DIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELH 162
DI GRL C + +L SY +QS GDY+ +H Y+SD P+Q ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 163 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINR 222
+ + + ++A+ ++ A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 223 FPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---R 279
+PW +LKIS+KR FFI R + E E + F + +YR+ K LWK CVEHHTFF +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 280 LTSTDTIPKSKFLALGSK-FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAA 338
L + S++ +GS+ + S Q + ++ PA + ++SL +
Sbjct: 182 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRS 241
Query: 339 AVDSAD-RSPR 348
+ + RSPR
Sbjct: 242 PPITPNWRSPR 252
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 156 bits (394), Expect = 6e-38
Identities = 73/198 (36%), Positives = 117/198 (59%), Gaps = 3/198 (1%)
Query: 103 DIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELH 162
DI GRL C + +L SY +QS GDY+ +H Y+SD P+Q ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 163 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINR 222
+ + + ++A+ ++ A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 223 FPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---R 279
+PW +LKIS+KR FFI R + E E + F + +YR+ K LWK CVEHHTFF +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 280 LTSTDTIPKSKFLALGSK 297
L + S++ +GS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 152 bits (383), Expect = 1e-36
Identities = 141/577 (24%), Positives = 253/577 (43%), Gaps = 51/577 (8%)
Query: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLD-----SAKEIKK 64
D E ++ + G+ L +V + + L E YFGL DN TWL SA+E++K
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 65 QVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYT 123
+ P F F KFYP D A+ L +DIT+ LQ+++ I++ + C T LLGSY
Sbjct: 73 EN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129
Query: 124 IQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVMELHKSYRSMTPAQADL 175
+Q++ GDY+ E+H Y+S +L P + + E+++ H +R M A L
Sbjct: 130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAML 189
Query: 176 EFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKIS 232
E+L+ A+ L MYG++ + K+ +G D+ LGV + GL +Y+ DKL FPW ++ IS
Sbjct: 190 EYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249
Query: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKF 291
+ F IK P +++ + F P R K++ ++C+ H + R DTI +
Sbjct: 250 FNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQM 305
Query: 292 LALGSKFRYSGRTQAQ----TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
A + ++ + + Q ++ ++R R + R D A+R
Sbjct: 306 KAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAEREL 365
Query: 348 RPTSAPAITQGQVAEGGVLDASAKKT--VVPKAQKETVKAEVKKEDEPPEQAEPEPTEAW 405
A+ + + +A + + KE ++ + + + EQ E E
Sbjct: 366 SEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYT 425
Query: 406 KK-------KRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHAS--------ISELKKNF 450
K +R + D + + +DL K++EE+ + + +
Sbjct: 426 AKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHV 485
Query: 451 MESVPE--PRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEI 508
ES+ + P+ + LS+ N +I E V+ Q +T+S + + E
Sbjct: 486 QESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDEN 545
Query: 509 PTKDVPIVHTETK---TITYEAAQTVKGGISETRIEK 542
I+H E Y+ + ++ G ++ RI++
Sbjct: 546 KRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDE 582
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 152 bits (383), Expect = 1e-36
Identities = 141/577 (24%), Positives = 253/577 (43%), Gaps = 51/577 (8%)
Query: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLD-----SAKEIKK 64
D E ++ + G+ L +V + + L E YFGL DN TWL SA+E++K
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 65 QVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYT 123
+ P F F KFYP D A+ L +DIT+ LQ+++ I++ + C T LLGSY
Sbjct: 73 EN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129
Query: 124 IQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVMELHKSYRSMTPAQADL 175
+Q++ GDY+ E+H Y+S +L P + + E+++ H +R M A L
Sbjct: 130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAML 189
Query: 176 EFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKIS 232
E+L+ A+ L MYG++ + K+ +G D+ LGV + GL +Y+ DKL FPW ++ IS
Sbjct: 190 EYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249
Query: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKF 291
+ F IK P +++ + F P R K++ ++C+ H + R DTI +
Sbjct: 250 FNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQM 305
Query: 292 LALGSKFRYSGRTQAQ----TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
A + ++ + + Q ++ ++R R + R D A+R
Sbjct: 306 KAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAEREL 365
Query: 348 RPTSAPAITQGQVAEGGVLDASAKKT--VVPKAQKETVKAEVKKEDEPPEQAEPEPTEAW 405
A+ + + +A + + KE ++ + + + EQ E E
Sbjct: 366 SEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYT 425
Query: 406 KK-------KRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHAS--------ISELKKNF 450
K +R + D + + +DL K++EE+ + + +
Sbjct: 426 AKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHV 485
Query: 451 MESVPE--PRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEI 508
ES+ + P+ + LS+ N +I E V+ Q +T+S + + E
Sbjct: 486 QESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDEN 545
Query: 509 PTKDVPIVHTETK---TITYEAAQTVKGGISETRIEK 542
I+H E Y+ + ++ G ++ RI++
Sbjct: 546 KRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDE 582
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 139 bits (350), Expect = 7e-33
Identities = 115/456 (25%), Positives = 208/456 (45%), Gaps = 32/456 (7%)
Query: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQV--R 67
D E ++ + G+ L +V + + L E +FGL D TWL K++ Q +
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72
Query: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
P F F KFYP D ++ L +DIT+ LQ+++ I+ + C T LL SY +QS
Sbjct: 73 ESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQS 132
Query: 127 ELGDYDPELHGVDYVSDFKLAPNQTKE--------LEEKVMELHKSYRSMTPAQADLEFL 178
+ GD++ E+H Y++ KL P + E EE++ H+ +R M A LE+L
Sbjct: 133 KYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYL 192
Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
+ A+ L MYGV+ K+ +G ++ LGV + GL +Y+ R+ FPW ++ IS+
Sbjct: 193 KIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFND 252
Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
F IK P +++ + F P R K++ +C+ H + R DTI + A
Sbjct: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308
Query: 295 GSKFRYSGRTQ----AQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPT 350
+ ++ + + ++ + ++ ER + R A +
Sbjct: 309 AREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQ 368
Query: 351 SAPAITQGQVAEGGVLDAS--AKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKK- 407
+ A+ Q + +A AK+ + KE + + + + EQ E E +
Sbjct: 369 TRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARI 428
Query: 408 -----KRERLDGENI-YIRHSNLMLEDLDKSQEEIK 437
R++ + E + + + + ++ EDL+K++ E+K
Sbjct: 429 SQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELK 464
Score = 29.6 bits (65), Expect = 8.1
Identities = 22/82 (26%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 381 ETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYI-RHSNLMLEDLDKSQEEIKKH 439
+ +KA+ +E++ +Q E E KKKRE + E I R ++E L + +E+ KK
Sbjct: 303 QQMKAQA-REEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
Query: 440 HASISELKKNFMESVPEPRPSE 461
+ E + +E E + ++
Sbjct: 362 QQELEEQTRRALELEQERKRAQ 383
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 137 bits (344), Expect = 4e-32
Identities = 127/465 (27%), Positives = 215/465 (46%), Gaps = 50/465 (10%)
Query: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
D E ++ + G+ L +V + + L E +FGL D+ TWL K++ +Q +
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72
Query: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
P F F KF+P D ++ L ++IT+ LQ+++ I+ + C T LL SY +Q+
Sbjct: 73 ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132
Query: 127 ELGDYDPELHGVDYVSDFKLAPNQ-------TKE-LEEKVMELHKSYRSMTPAQADLEFL 178
+ GDY+ E+H Y+++ +L P + TKE EE++ H+ +R M + +E+L
Sbjct: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192
Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKISYKR 235
+ A+ L MYGV+ + K+ +G ++ LGV + GL +Y+ DKL FPW ++ IS+
Sbjct: 193 KIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFND 252
Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
F IK P +++ + F P R K++ +C+ H + R DTI + A
Sbjct: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308
Query: 295 GSKFRYS---GRTQAQT----------------RQASALIDRPAPHFERT--ASKRASRS 333
+ ++ R Q + R+ L++R E+T A K
Sbjct: 309 AREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQ 368
Query: 334 LDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEP 393
A +D +R A + + + A A AK+ +E + AE+ +
Sbjct: 369 TRKALELDQ-ERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAK 427
Query: 394 PEQAEPEPTEAWKKKRERLDGENIYIRHSNLML-EDLDKSQEEIK 437
E EA KKK E E +H EDL+K++EE+K
Sbjct: 428 IALLE----EAKKKKEE----EATEWQHKAFAAQEDLEKTKEELK 464
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 132 bits (332), Expect = 9e-31
Identities = 110/471 (23%), Positives = 207/471 (43%), Gaps = 25/471 (5%)
Query: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
D E E KG+DL VC L L E +FGL T WL K++ +
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTV-AWLKMDKKVLDHDVSK 88
Query: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
P F F KFYP + + L ++IT++ LQ+++ I+ ++ C LL SY +Q+
Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
Query: 127 ELGDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFL 178
+ GDYDP +H +++ +L P + L EE++ + +R +A++E+L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
+ A+ L MYGV+ ++ +G +++LGV + GL +Y + R+ FPW ++ ISY
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
F IK + + ++ F R K + ++C+ H F R D++ + A
Sbjct: 269 KEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324
Query: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPA 354
+ + + + Q + A +R + + A + A T+
Sbjct: 325 AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLL 384
Query: 355 ITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDG 414
+ Q+ E A+K + + + +KA + +E E + EA + +
Sbjct: 385 AEKAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 443
Query: 415 ENIYIRHSNLMLEDLDKSQEEIKKHHASISEL--KKNF--MESVPEPRPSE 461
+ ++ + +DL +++E ++ + E+ K + M +P P P +
Sbjct: 444 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPD 494
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 132 bits (332), Expect = 9e-31
Identities = 110/471 (23%), Positives = 207/471 (43%), Gaps = 25/471 (5%)
Query: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
D E E KG+DL VC L L E +FGL T WL K++ +
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTV-AWLKMDKKVLDHDVSK 88
Query: 68 GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
P F F KFYP + + L ++IT++ LQ+++ I+ ++ C LL SY +Q+
Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
Query: 127 ELGDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFL 178
+ GDYDP +H +++ +L P + L EE++ + +R +A++E+L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
+ A+ L MYGV+ ++ +G +++LGV + GL +Y + R+ FPW ++ ISY
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
F IK + + ++ F R K + ++C+ H F R D++ + A
Sbjct: 269 KEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324
Query: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPA 354
+ + + + Q + A +R + + A + A T+
Sbjct: 325 AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLL 384
Query: 355 ITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDG 414
+ Q+ E A+K + + + +KA + +E E + EA + +
Sbjct: 385 AEKAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 443
Query: 415 ENIYIRHSNLMLEDLDKSQEEIKKHHASISEL--KKNF--MESVPEPRPSE 461
+ ++ + +DL +++E ++ + E+ K + M +P P P +
Sbjct: 444 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPD 494
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,966,368
Number of Sequences: 37866
Number of extensions: 1064598
Number of successful extensions: 4426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 131
Number of HSP's that attempted gapping in prelim test: 4040
Number of HSP's gapped (non-prelim): 453
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.