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Search of human proteins with 4757956
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4757956 cadherin 16 precursor [Homo sapiens]
(829 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4757956 cadherin 16 precursor [Homo sapiens] 1675 0.0
gi|221316595 cadherin 17 precursor [Homo sapiens] 350 4e-96
gi|221316593 cadherin 17 precursor [Homo sapiens] 350 4e-96
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 184 2e-46
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 182 1e-45
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 181 3e-45
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 177 5e-44
gi|16933557 dachsous 1 precursor [Homo sapiens] 175 1e-43
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 167 5e-41
gi|29570800 cadherin-like 26 isoform a [Homo sapiens] 156 7e-38
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 154 2e-37
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 151 2e-36
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 151 3e-36
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 151 3e-36
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 146 9e-35
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 145 1e-34
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 144 3e-34
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 140 6e-33
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 139 8e-33
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 137 3e-32
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 137 3e-32
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 137 3e-32
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 137 5e-32
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 136 9e-32
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 133 8e-31
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 132 1e-30
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 132 1e-30
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 131 3e-30
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 130 5e-30
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 129 9e-30
>gi|4757956 cadherin 16 precursor [Homo sapiens]
Length = 829
Score = 1675 bits (4337), Expect = 0.0
Identities = 829/829 (100%), Positives = 829/829 (100%)
Query: 1 MVPAWLWLLCVSVPQALPKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGD 60
MVPAWLWLLCVSVPQALPKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGD
Sbjct: 1 MVPAWLWLLCVSVPQALPKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGD 60
Query: 61 SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEN 120
SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEN
Sbjct: 61 SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEN 120
Query: 121 DQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMF 180
DQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMF
Sbjct: 121 DQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMF 180
Query: 181 QLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVS 240
QLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVS
Sbjct: 181 QLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVS 240
Query: 241 LEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQA 300
LEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQA
Sbjct: 241 LEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQA 300
Query: 301 EYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA 360
EYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA
Sbjct: 301 EYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA 360
Query: 361 EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAM 420
EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAM
Sbjct: 361 EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAM 420
Query: 421 DLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLE 480
DLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLE
Sbjct: 421 DLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLE 480
Query: 481 PAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVG 540
PAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVG
Sbjct: 481 PAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVG 540
Query: 541 PGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRTLRFSL 600
PGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRTLRFSL
Sbjct: 541 PGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRTLRFSL 600
Query: 601 VNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAP 660
VNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAP
Sbjct: 601 VNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAP 660
Query: 661 PAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQT 720
PAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQT
Sbjct: 661 PAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQT 720
Query: 721 LNGSHAYLTLALHWVEPREHIIPVVVSHNAQMWQLLVRVIVCRCNVEGQCMRKVGRMKGM 780
LNGSHAYLTLALHWVEPREHIIPVVVSHNAQMWQLLVRVIVCRCNVEGQCMRKVGRMKGM
Sbjct: 721 LNGSHAYLTLALHWVEPREHIIPVVVSHNAQMWQLLVRVIVCRCNVEGQCMRKVGRMKGM 780
Query: 781 PTKLSAVGILVGTLVAIGIFLILIFTHWTMSRKKDPDQPADSVPLKATV 829
PTKLSAVGILVGTLVAIGIFLILIFTHWTMSRKKDPDQPADSVPLKATV
Sbjct: 781 PTKLSAVGILVGTLVAIGIFLILIFTHWTMSRKKDPDQPADSVPLKATV 829
>gi|221316595 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 350 bits (897), Expect = 4e-96
Identities = 234/773 (30%), Positives = 390/773 (50%), Gaps = 21/773 (2%)
Query: 65 TEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
T+ F ++ + G L RALDRE ++ + LQV +G ++ GP P+ + VKD ND P
Sbjct: 66 TDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRP 124
Query: 125 HFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEP 184
F Q+ Y + + +RPG PFL++ A+D D+P T N L + I+ Q P + FQ+
Sbjct: 125 TFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINN 184
Query: 185 RLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQA-SGHQATATVEVSIIESTWVSLEP 243
+ GA++L+ +GS L+ A +Y L++ VKDMG Q+ + T +V++ + E+ W + +P
Sbjct: 185 KTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKP 244
Query: 244 IHLAENLKVLYPHHMAQVHWSGGDVHYHL---ESHPPGPFEVNAEGNLYVTRELDREAQA 300
+ + EN +P + QV W+ Y L E P PF ++ EG++YVT+ LDRE +
Sbjct: 245 VEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKD 304
Query: 301 EYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA 360
Y+ A++ +G+ + PLE+HV V D NDN P CP + E G + L+A
Sbjct: 305 AYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTA 364
Query: 361 EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAM 420
D D + NS + Y+++ P+ ++G F + +G + L L+ Q+ L +
Sbjct: 365 HDRDEENTANSFLNYRIVEQTPKLPMDG-LFLIQTYAGMLQLAKQSLKK-QDTPQYNLTI 422
Query: 421 DLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLE 480
+++ + F + C V++ V DIND P F S G ++L ED G+ + + A DAD E
Sbjct: 423 EVSDKD--FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDAD-E 479
Query: 481 P--AFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKL 538
P + + I +GD+EG G+D +P + + + K L +E A +V ++ L
Sbjct: 480 PFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPL 539
Query: 539 V-GPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRTLR 597
V G + A T++V V P+ Q ++A V G+ + + DP +
Sbjct: 540 VFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDIS 599
Query: 598 FSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFL 657
+SL D+ GWL I+ +GE+ + L + G Y V V A + LS+ + + +
Sbjct: 600 YSLRGDTRGWLKIDHVTGEIFSVAPLD-REAGSPYRVQVVATEVGGSSLSSVSEFHLILM 658
Query: 658 KAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGP-YSFTLGPNPTVQRDW 716
P + C P G ++ + D D GP ++F+LG + ++Q DW
Sbjct: 659 DVNDNPPRLAKDYTGLFFCHPLSAPGSLIF-EATDDDQHLFRGPHFTFSLG-SGSLQNDW 716
Query: 717 RLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNAQ---MWQLLVRVIVCRCNVEGQCMRK 773
+ +NG+HA L+ E RE+++ + ++ + + + V C C VEG C R
Sbjct: 717 EVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSC-VEGSCFRP 775
Query: 774 VGRMKGMPTKLSAVGILVGTLVAIGIFLILIFTHWTMSRKKDPDQPADSVPLK 826
G G+PT AVGIL+ TL+ IGI L ++F + KD + A + +K
Sbjct: 776 AGHQTGIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVK 828
Score = 80.1 bits (196), Expect = 8e-15
Identities = 112/444 (25%), Positives = 182/444 (40%), Gaps = 61/444 (13%)
Query: 268 VHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVM 327
V + L F + EG LY R LDRE ++ + LQV A +++G P+ + + V
Sbjct: 58 VTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVK 117
Query: 328 DENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVE 387
D NDN P S+ + S PG ++A D D P +PN + YQ++ P
Sbjct: 118 DINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMIN-N 176
Query: 388 GRAFQVDPTSGSVTL---GVLPLRAGQN--ILLLVLAMDLAG-AEGGFSSTCEVEVAVTD 441
FQ++ +G+++L G L +N L++ D+ G +E FS T V++ VT+
Sbjct: 177 VMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTE 236
Query: 442 INDHAP---EFITSQIGP----ISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIER-G 493
AP E + + P I+ +PG A + +D + P F F+I++ G
Sbjct: 237 NIWKAPKPVEMVENSTDPHPIKITQVRWNDPG---AQYSLVDKEKLPRF---PFSIDQEG 290
Query: 494 DTEGTFGLDWEPDSGHVRLRLCKN-----LSY---------------EAAPSHEVVVVVQ 533
D T LD E +V + K+ LSY PS V VQ
Sbjct: 291 DIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQ 350
Query: 534 -------SVAKLVGPGPGPGATATVTVLVERVMPPPKLDQ------ESYEASVPISAPA- 579
S+ L TA + V PKL ++Y + ++ +
Sbjct: 351 ENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSL 410
Query: 580 -----GSFLLTIQPSDPISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTV 634
+ LTI+ SD +TL F +N + I F + +L + +
Sbjct: 411 KKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTIL 470
Query: 635 LVEAQDTDEPRLSASAPLVIHFLK 658
++A D DEP + S+ ++ H +K
Sbjct: 471 TIQATDADEP-FTGSSKILYHIIK 493
>gi|221316593 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 350 bits (897), Expect = 4e-96
Identities = 234/773 (30%), Positives = 390/773 (50%), Gaps = 21/773 (2%)
Query: 65 TEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
T+ F ++ + G L RALDRE ++ + LQV +G ++ GP P+ + VKD ND P
Sbjct: 66 TDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRP 124
Query: 125 HFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEP 184
F Q+ Y + + +RPG PFL++ A+D D+P T N L + I+ Q P + FQ+
Sbjct: 125 TFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINN 184
Query: 185 RLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQA-SGHQATATVEVSIIESTWVSLEP 243
+ GA++L+ +GS L+ A +Y L++ VKDMG Q+ + T +V++ + E+ W + +P
Sbjct: 185 KTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKP 244
Query: 244 IHLAENLKVLYPHHMAQVHWSGGDVHYHL---ESHPPGPFEVNAEGNLYVTRELDREAQA 300
+ + EN +P + QV W+ Y L E P PF ++ EG++YVT+ LDRE +
Sbjct: 245 VEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKD 304
Query: 301 EYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA 360
Y+ A++ +G+ + PLE+HV V D NDN P CP + E G + L+A
Sbjct: 305 AYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTA 364
Query: 361 EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAM 420
D D + NS + Y+++ P+ ++G F + +G + L L+ Q+ L +
Sbjct: 365 HDRDEENTANSFLNYRIVEQTPKLPMDG-LFLIQTYAGMLQLAKQSLKK-QDTPQYNLTI 422
Query: 421 DLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLE 480
+++ + F + C V++ V DIND P F S G ++L ED G+ + + A DAD E
Sbjct: 423 EVSDKD--FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDAD-E 479
Query: 481 P--AFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKL 538
P + + I +GD+EG G+D +P + + + K L +E A +V ++ L
Sbjct: 480 PFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPL 539
Query: 539 V-GPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRTLR 597
V G + A T++V V P+ Q ++A V G+ + + DP +
Sbjct: 540 VFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDIS 599
Query: 598 FSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFL 657
+SL D+ GWL I+ +GE+ + L + G Y V V A + LS+ + + +
Sbjct: 600 YSLRGDTRGWLKIDHVTGEIFSVAPLD-REAGSPYRVQVVATEVGGSSLSSVSEFHLILM 658
Query: 658 KAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGP-YSFTLGPNPTVQRDW 716
P + C P G ++ + D D GP ++F+LG + ++Q DW
Sbjct: 659 DVNDNPPRLAKDYTGLFFCHPLSAPGSLIF-EATDDDQHLFRGPHFTFSLG-SGSLQNDW 716
Query: 717 RLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNAQ---MWQLLVRVIVCRCNVEGQCMRK 773
+ +NG+HA L+ E RE+++ + ++ + + + V C C VEG C R
Sbjct: 717 EVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSC-VEGSCFRP 775
Query: 774 VGRMKGMPTKLSAVGILVGTLVAIGIFLILIFTHWTMSRKKDPDQPADSVPLK 826
G G+PT AVGIL+ TL+ IGI L ++F + KD + A + +K
Sbjct: 776 AGHQTGIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVK 828
Score = 80.1 bits (196), Expect = 8e-15
Identities = 112/444 (25%), Positives = 182/444 (40%), Gaps = 61/444 (13%)
Query: 268 VHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVM 327
V + L F + EG LY R LDRE ++ + LQV A +++G P+ + + V
Sbjct: 58 VTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVK 117
Query: 328 DENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVE 387
D NDN P S+ + S PG ++A D D P +PN + YQ++ P
Sbjct: 118 DINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMIN-N 176
Query: 388 GRAFQVDPTSGSVTL---GVLPLRAGQN--ILLLVLAMDLAG-AEGGFSSTCEVEVAVTD 441
FQ++ +G+++L G L +N L++ D+ G +E FS T V++ VT+
Sbjct: 177 VMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTE 236
Query: 442 INDHAP---EFITSQIGP----ISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIER-G 493
AP E + + P I+ +PG A + +D + P F F+I++ G
Sbjct: 237 NIWKAPKPVEMVENSTDPHPIKITQVRWNDPG---AQYSLVDKEKLPRF---PFSIDQEG 290
Query: 494 DTEGTFGLDWEPDSGHVRLRLCKN-----LSY---------------EAAPSHEVVVVVQ 533
D T LD E +V + K+ LSY PS V VQ
Sbjct: 291 DIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQ 350
Query: 534 -------SVAKLVGPGPGPGATATVTVLVERVMPPPKLDQ------ESYEASVPISAPA- 579
S+ L TA + V PKL ++Y + ++ +
Sbjct: 351 ENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSL 410
Query: 580 -----GSFLLTIQPSDPISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTV 634
+ LTI+ SD +TL F +N + I F + +L + +
Sbjct: 411 KKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTIL 470
Query: 635 LVEAQDTDEPRLSASAPLVIHFLK 658
++A D DEP + S+ ++ H +K
Sbjct: 471 TIQATDADEP-FTGSSKILYHIIK 493
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 184 bits (468), Expect = 2e-46
Identities = 178/616 (28%), Positives = 275/616 (44%), Gaps = 50/616 (8%)
Query: 231 VSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSG---GDVHYHLES-----HPPGPFEV 282
+S + WV + PI ++EN K L P+ + Q+ G V Y ++ P G F +
Sbjct: 40 LSRVRRAWV-IPPISVSENHKRL-PYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSI 97
Query: 283 NA-EGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDP 341
+ G +++ LDRE + L+ A + G P +L ++V+D+NDN P
Sbjct: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157
Query: 342 TVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLL---SPEPEDGVEGRAFQVDPTSG 398
T + E + PGT VTR A DAD P + N+ + + +L SPE F +D +G
Sbjct: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPE--------LFSIDELTG 209
Query: 399 SVTLGVLPLRAGQNILLLVLAMDLAGAEG-GFSSTCEVEVAVTDINDHAPEFITSQIGPI 457
+ + L + + + L + +A G G ++T + + DIND+APEF +
Sbjct: 210 EIRTVQVGLDR-EVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFME 268
Query: 458 SLPEDVEPGTLVAMLTAIDADLEPAFR-LMDFAIERGDTEGTFGLDWEPDSGHVRLRLCK 516
++ + G V L D DL + + F I GD +G F + +P + L + K
Sbjct: 269 AI--EAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVK 326
Query: 517 NLSYEAAPSHEVVVVVQSVAKLVGPG-PGPGATATVTVLVERVMPPPKLDQESYEASVPI 575
L YE+ +E+ V VQ+ A L A V V V+ PP + S+
Sbjct: 327 ALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAE 386
Query: 576 SAPAGSFLLTIQPSDPISRTLR---FSLVNDSEGWLCIEKFSGEVHTAQSLQGAQP---G 629
AP G+ + T DP + L+ +S D E WL ++ +G + T L A P G
Sbjct: 387 GAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKG 446
Query: 630 DTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCT-PRQDHGLIVSG 688
Y +V AQD +A+ L I L+ A LAP P LC+ P Q GL++
Sbjct: 447 GWYRAIVLAQDDASQPRTATGTLSIEILEVND-HAPVLAPPPPGSLCSEPHQGPGLLLG- 504
Query: 689 PSKDPDLASGHGPYSFTLGPN-PTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVS 747
+ D DL P+ F L P P + R+W L +N SHA L H V H + +++
Sbjct: 505 -ATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLR-PRHQVPEGLHRLSLLLR 562
Query: 748 HNAQMWQLL---VRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIGIFLILI 804
+ Q Q + V VCRC +G C+ + T LS +G LV L + + L+L+
Sbjct: 563 DSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLS-LGALVIVLASALLLLVLV 621
Query: 805 F------THWTMSRKK 814
W SR K
Sbjct: 622 LLVALRARFWKQSRGK 637
Score = 114 bits (286), Expect = 3e-25
Identities = 130/476 (27%), Positives = 192/476 (40%), Gaps = 52/476 (10%)
Query: 67 GPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHF 126
G F++D +G + + LDRE+ ++L+ G L P + + V D+ND P F
Sbjct: 93 GVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAF 152
Query: 127 SQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRL 186
Q + R+ G PG EA+D D+P T N+ LRF IL Q SP++F ++
Sbjct: 153 LQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQG----SPELFSIDELT 208
Query: 187 GALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSL-EPIH 245
G + G LD + Y L +QV DM A+A + + I
Sbjct: 209 GEIRTVQVG---LDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEF 265
Query: 246 LAENLKVLYPHHMAQVHWSGGDV---------HYHLESHPPGPFEVNA-----EGNLYVT 291
E ++ + + ++ D+ LE P G F + EG L +
Sbjct: 266 FMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIV 325
Query: 292 RELDREAQAEYLLQVRAQNSHGEDYAA------PLELHVLVMDENDNVPICPPRDPTVSI 345
+ LD E+ Y L+V QN AA ++ V V D N+ P+ S+
Sbjct: 326 KALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNE-PPVFQENPLRTSL 384
Query: 346 PELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGV 404
E +PPGT V SA D P + + +PED + QVD +G + T V
Sbjct: 385 AEGAPPGTLVATFSARD---PDTEQLQRLSYSKDYDPEDWL-----QVDAATGRIQTQHV 436
Query: 405 L----PLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLP 460
L P G +VLA D A + T +E + ++NDHAP G +
Sbjct: 437 LSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIE--ILEVNDHAPVLAPPPPGSLCSE 494
Query: 461 EDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDW---EPDSGHVRLR 513
PG L L A D DL P F + E G +W + + H RLR
Sbjct: 495 PHQGPGLL---LGATDEDLPPHGAPFHFQLSPRLPE--LGRNWSLSQVNVSHARLR 545
Score = 42.4 bits (98), Expect = 0.002
Identities = 47/190 (24%), Positives = 75/190 (39%), Gaps = 24/190 (12%)
Query: 56 VLSGDSGKATEGPFAMDPD----SGFLLVTRALDREEQAEYQLQVTLEMQDG------HV 105
+L GD +G F + D G L + +ALD E Y+L+V+++ +
Sbjct: 300 ILEGDP----DGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRA 355
Query: 106 LWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRF 165
G V VHV+D N+ P F + R L+ G PG A D D +
Sbjct: 356 ERGQAKVRVHVQDTNEP-PVFQENPLRTSLAEGAPPGTLVATFSARDPDTE-------QL 407
Query: 166 HILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQA 225
LS + D Q++ G + S + Y+ +V +D D + A
Sbjct: 408 QRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQD--DASQPRTA 465
Query: 226 TATVEVSIIE 235
T T+ + I+E
Sbjct: 466 TGTLSIEILE 475
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 182 bits (462), Expect = 1e-45
Identities = 189/734 (25%), Positives = 320/734 (43%), Gaps = 61/734 (8%)
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F + +Y A LS+ G P L ++ S+ N + S PA D +
Sbjct: 36 FPEDVYSAVLSKDVHEGQPLLNVKFSN------CNGKRKVQYESSEPADFKVDEDGMVYA 89
Query: 186 LGALALSPKGSTSLDHALERTYQLLVQVK---DMGDQASGHQATATVEVSII-------- 234
+ + LS + + L +A ++ Q QV + + + EV I
Sbjct: 90 VRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSK 149
Query: 235 --------ESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHL---------ESHPP 277
+ WV + PI+L EN + +P + ++ S D + L + P
Sbjct: 150 HSGHLQRQKRDWV-IPPINLPENSRGPFPQELVRIR-SDRDKNLSLRYSVTGPGADQPPT 207
Query: 278 GPFEVNA-EGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPIC 336
G F +N G L VT+ LDRE A + L+ A + +G P+++ + V+D NDN P
Sbjct: 208 GIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEF 267
Query: 337 PPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPT 396
+ ++PE S PGT V ++A DAD P + N + Y+++S P + T
Sbjct: 268 LHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNET 327
Query: 397 SGSVTLGV-LPLRAGQNILLLVLAMDLAGAEG-GFSSTCEVEVAVTDINDHAPEFITSQI 454
+T+ L Q L++ A D+ G G S+T + VTD+ND+ PEF T+
Sbjct: 328 GDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEF-TAMT 386
Query: 455 GPISLPEDVEPGTLVAMLTAIDADLE--PAFRLMDFAIERGDTEGTFGLDWEPDSGHVRL 512
+PE+ +VA LT D D PA+ + + I GD G F + +P+S +
Sbjct: 387 FYGEVPEN-RVDIIVANLTVTDKDQPHTPAWNAV-YRISGGDPTGRFAIQTDPNSNDGLV 444
Query: 513 RLCKNLSYEAAPSHEVVVVVQSVAKLV-GPGPGPGATATVTVLVERVMPPPKLDQESYEA 571
+ K + +E + V ++ L G P +TATV+V V V P
Sbjct: 445 TVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKII 504
Query: 572 SVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQP 628
AG+ L T DP + + +R++ ++D WL I+ +G++ T L P
Sbjct: 505 RQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESP 564
Query: 629 G---DTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLI 685
+ Y A D P +S + L I+ L L P ++ TP +
Sbjct: 565 NVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVL-PQEAETCETPDPNS--- 620
Query: 686 VSGPSKDPDLASGHGPYSFTLGPNP-TVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPV 744
++ + D D+ GP++F L +P T++R+W + LNG A L L + ++E + +P+
Sbjct: 621 INITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPI 680
Query: 745 VVSHNAQMWQ---LLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIGIFL 801
+++ + + ++RV VC+C+ G C V R+ G A+ I + + I + L
Sbjct: 681 IITDSGNPPKSNISILRVKVCQCDSNGDC-TDVDRIVGAGLGTGAI-IAILLCIIILLIL 738
Query: 802 ILIFTHWTMSRKKD 815
+L+F W R K+
Sbjct: 739 VLMFVVWMKRRDKE 752
Score = 137 bits (345), Expect = 4e-32
Identities = 128/494 (25%), Positives = 219/494 (44%), Gaps = 66/494 (13%)
Query: 27 VEVPENYGGNFPLYLTKLPLPREG--AEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRAL 84
+ +PEN G FP L ++ R+ + V + + G F ++P SG L VT+ L
Sbjct: 166 INLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPL 225
Query: 85 DREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIP 144
DRE+ A + L+ +G+ + P ++++V D ND P F ++ + G++PG
Sbjct: 226 DREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTY 285
Query: 145 FLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALE 204
+ + A D D+P N LR+ I+SQAP+ PSP+MF + G + G LD
Sbjct: 286 VMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAG---LDREKV 342
Query: 205 RTYQLLVQVKDM-GDQASGHQATATVEVSIIE----------STWVSLEPIH----LAEN 249
+ Y L++Q DM G+ G TAT +++ + T+ P + + N
Sbjct: 343 QQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVAN 402
Query: 250 LKVL------YPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGN-----LYVTRELDREA 298
L V P A SGGD P G F + + N + V + +D E
Sbjct: 403 LTVTDKDQPHTPAWNAVYRISGGD--------PTGRFAIQTDPNSNDGLVTVVKPIDFET 454
Query: 299 QAEYLLQVRAQN--------SHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSP 350
++L V A+N H A + + V+ ++EN P P + E
Sbjct: 455 NRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNEN---PYFAPNPKIIRQEEGLH 511
Query: 351 PGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAG 410
GT +T +A+D D N + Y LS +P + + ++DP +G +T + R
Sbjct: 512 AGTMLTTFTAQDPDRYMQQN--IRYTKLS-DPANWL-----KIDPVNGQITTIAVLDRES 563
Query: 411 QNILLLVLAMDLAGAEGG---FSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGT 467
N+ + ++ G S T +++ + DIND+AP+ + + P +P +
Sbjct: 564 PNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETP---DPNS 620
Query: 468 LVAMLTAIDADLEP 481
+ +TA+D D++P
Sbjct: 621 I--NITALDYDIDP 632
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 181 bits (458), Expect = 3e-45
Identities = 158/566 (27%), Positives = 257/566 (45%), Gaps = 48/566 (8%)
Query: 239 VSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYH-------LESHPPGPFEVNAE-GNLYV 290
+ + PI + EN + +P + +V S ++ P G F +N G++ V
Sbjct: 140 IVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSV 199
Query: 291 TRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSP 350
TR LDRE A Y L V + +G+ P+ L V+V+D+NDN PI + E SP
Sbjct: 200 TRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSP 259
Query: 351 PGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAG 410
GT V R++A DAD P + N+ + Y + P D F +DP G + V P
Sbjct: 260 TGTTVMRMTAFDADDPATDNALLRYNIRQQTP-DKPSPNMFYIDPEKGDIVTVVSPALLD 318
Query: 411 QNIL------LLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVE 464
+ L L++ A D+AG + G + T + + D NDH+P+F + VE
Sbjct: 319 RETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEF-----QATVE 373
Query: 465 PGTL--VAMLTAIDADLEP---AFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLS 519
G + + LT D D +P A+R + I G+ +F + P + L + K L
Sbjct: 374 EGAVGVIVNLTVEDKD-DPTTGAWRAA-YTIINGNPGQSFEIHTNPQTNEGMLSVVKPLD 431
Query: 520 YEAAPSHEVVVVVQSVAKLVGP-GPGPGATATVTVLVERVMPPPKLDQESYEASVPISAP 578
YE + H +++ V++ LV GP +TATV + V V P + +
Sbjct: 432 YEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLS 491
Query: 579 AGSFLLTIQPSDPIS---RTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQP---GDTY 632
GS LLT+ +DP S +T+R+S+ D GWL I +G V T L P Y
Sbjct: 492 VGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVDNSVY 551
Query: 633 TVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKD 692
T L A D+ P + + L+I L+ A + P ++ +C ++ +++ G S D
Sbjct: 552 TALFLAIDSGNPPATGTGTLLI-TLEDVNDNAPFIYPTVAE-VCDDAKNLSVVILGAS-D 608
Query: 693 PDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNAQ- 751
DL P+ F + + W++ +N +HA ++L L + + +P++V+ + +
Sbjct: 609 KDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSL-LQNLNKANYNLPIMVTDSGKP 667
Query: 752 ----MWQLLVRVIVCR-----CNVEG 768
+ L V+V CR CN G
Sbjct: 668 PMTNITDLRVQVCSCRNSKVDCNAAG 693
Score = 122 bits (307), Expect = 1e-27
Identities = 132/522 (25%), Positives = 220/522 (42%), Gaps = 48/522 (9%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQIVLSGDS-GKATEGPFAMDPDSGFLLVTRALDRE 87
+PEN FP + K+ + L+G + +G F ++ ++G + VTR LDRE
Sbjct: 147 IPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDRE 206
Query: 88 EQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLF 147
A YQL V +G L GP P+ V V D+ND P F + Y + G+ G +
Sbjct: 207 VIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMR 266
Query: 148 LEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER-T 206
+ A D D+P T N+ LR++I Q P +PSP+MF ++P G + + LE
Sbjct: 267 MTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPK 326
Query: 207 YQLLVQVKDMGDQASGHQATATVEVSIIE-------------STWVSLEPIHLAENLKVL 253
Y+L+++ +DM G TAT + I + V + + NL V
Sbjct: 327 YELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVE 386
Query: 254 YPHHMAQVHWSGGDVHYHLESHPPGPFEVNA-----EGNLYVTRELDREAQAEYLLQVRA 308
W + + +P FE++ EG L V + LD E A + L ++
Sbjct: 387 DKDDPTTGAWRA--AYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKV 444
Query: 309 QN--------SHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA 360
+N S+G A +H+ V+D N+ P+ P V+ E G+ + ++A
Sbjct: 445 ENEDPLVPDVSYGPSSTA--TVHITVLDVNEG-PVFYPDPMMVTRQEDLSVGSVLLTVNA 501
Query: 361 EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAG--QNILLLV 417
D P S + + +P + ++P +G+V T VL + N +
Sbjct: 502 TD---PDSLQHQTIRYSVYKDPAGWL-----NINPINGTVDTTAVLDRESPFVDNSVYTA 553
Query: 418 LAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDA 477
L + + + T + + + D+ND+AP FI + + D V +L A D
Sbjct: 554 LFLAIDSGNPPATGTGTLLITLEDVNDNAP-FIYPTVAEVC---DDAKNLSVVILGASDK 609
Query: 478 DLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLS 519
DL P F I + + ++ H + L +NL+
Sbjct: 610 DLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLN 651
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 177 bits (448), Expect = 5e-44
Identities = 162/608 (26%), Positives = 277/608 (45%), Gaps = 46/608 (7%)
Query: 238 WVSLEPIHLAENLKVLYPHHMAQVHWSGGD---VHYHL-----ESHPPGPFEVNA-EGNL 288
WV + PI++ EN + +P + ++ + + Y + + P F +++ G +
Sbjct: 171 WV-IPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRM 229
Query: 289 YVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPEL 348
YVTR +DRE A Y L+ A + +G P++L++ V+D NDN P + S+ E
Sbjct: 230 YVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEG 289
Query: 349 SPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGV-LPL 407
S PGT V ++A DAD + N V Y++++ P+ + T VT+ L
Sbjct: 290 SKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDR 349
Query: 408 RAGQNILLLVLAMDLAG-AEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPG 466
Q ++V A D+ G G S+T + VTD+ND+ PEF S +PE+
Sbjct: 350 EKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAG-EVPEN-RVE 407
Query: 467 TLVAMLTAIDADL--EPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAP 524
T+VA LT +D D P + + + I GD G F + +P + + + K + YE
Sbjct: 408 TVVANLTVMDRDQPHSPNWNAV-YRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNR 466
Query: 525 SHEVVVVVQSVAKLV-GPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFL 583
+ + V+V + A L G +TA VT+ + + P + P G+ L
Sbjct: 467 AFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVL 526
Query: 584 LTIQPSDP---ISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQ---PGDTYTVLVE 637
T DP + + +R+S ++D WL I +G++ TA L + Y
Sbjct: 527 TTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFL 586
Query: 638 AQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLAS 697
A D P S + L I+ + A L P +Q P + ++ + D D+
Sbjct: 587 AADNGIPPASGTGTLQIYLIDINDN-APELLPKEAQICEKPNLN---AINITAADADVDP 642
Query: 698 GHGPYSFTLGPNPT-VQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNAQ---MW 753
GPY F L P V+++W + LNG +A L+L + ++E + +P++V+ +
Sbjct: 643 NIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSN 702
Query: 754 QLLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIGI------FLILIFTH 807
+++V VC C+ G C +G ++A G+ G +VAI I ++L+F
Sbjct: 703 TSIIKVKVCPCDDNGDC-TTIG-------AVAAAGLGTGAIVAILICILILLTMVLLFVM 754
Query: 808 WTMSRKKD 815
W R+K+
Sbjct: 755 WMKRREKE 762
Score = 141 bits (355), Expect = 3e-33
Identities = 131/489 (26%), Positives = 211/489 (43%), Gaps = 56/489 (11%)
Query: 27 VEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGD-SGKATEGP----FAMDPDSGFLLVT 81
+ VPEN G FP L ++ R + I + +G + P F++D SG + VT
Sbjct: 176 INVPENSRGPFPQQLVRI---RSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVT 232
Query: 82 RALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRP 141
R +DREE A Y L+ +G+ + P + ++V D ND P F +Y + G++P
Sbjct: 233 RPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKP 292
Query: 142 GIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDH 201
G + + A+D D+ TAN +R+ I++Q P PS +MF + G + G LD
Sbjct: 293 GTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAG---LDR 349
Query: 202 ALERTYQLLVQVKDM-GDQASGHQATATVEVSIIE----------STWVSLEPIHLAE-- 248
+ Y ++VQ DM G+ G TAT +++ + ST+ P + E
Sbjct: 350 EKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETV 409
Query: 249 --NLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNA-----EGNLYVTRELDREAQAE 301
NL V+ +W+ V+ + P G F V EG + V + +D E
Sbjct: 410 VANLTVMDRDQPHSPNWNA--VYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRA 467
Query: 302 YLLQVRAQNSH------GEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEV 355
++L V N + + + + +MD N+ P P + + E PPGT +
Sbjct: 468 FMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINE-APYFPSNHKLIRLEEGVPPGTVL 526
Query: 356 TRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILL 415
T SA D D V Y LS +P + ++ T+G +T + R
Sbjct: 527 TTFSAVDPDR--FMQQAVRYSKLS-DPASWL-----HINATNGQITTAAVLDRESLYTKN 578
Query: 416 LVLAMDLAGAEGGF---SSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAML 472
V A+ G S T +++ + DIND+APE + P +P +
Sbjct: 579 NVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELL-----PKEAQICEKPNLNAINI 633
Query: 473 TAIDADLEP 481
TA DAD++P
Sbjct: 634 TAADADVDP 642
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 175 bits (444), Expect = 1e-43
Identities = 199/663 (30%), Positives = 277/663 (41%), Gaps = 59/663 (8%)
Query: 41 LTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEM 100
L + P G + + G EG FA+D SG L + R LD E ++
Sbjct: 1351 LGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAE 1410
Query: 101 QDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTAN 160
G V V V+DEN+ P F++ L PG ASD D PG N
Sbjct: 1411 GPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPG-PN 1469
Query: 161 SDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQA 220
SD+R+ +L Q P P+ +L+ R GAL+ +P+G LD LLV+ D A
Sbjct: 1470 SDVRYRLLRQEPPVPA---LRLDARTGALS-APRG---LDRETTPALLLLVEATDRPANA 1522
Query: 221 SGHQATATVEVSIIESTWVSLEPIHLAEN---LKVLYPHHMAQVHWSGGD--------VH 269
S +A A V + + P+ + + L P A +H D V
Sbjct: 1523 SRRRA-ARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVS 1581
Query: 270 YHLESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMD 328
Y L S G F +++ G L V R LDRE +AE++L V A + +A L V V D
Sbjct: 1582 YRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVAD 1641
Query: 329 ENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEG 388
ND P ++ +V + E +PPGT + L A D D N V Y GV
Sbjct: 1642 VNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDV--GANGQVTY--------GGVSS 1691
Query: 389 RAFQVDPTSGSV-TLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAP 447
+F +DP +G + TL L + I L V A D T V VAV D NDHAP
Sbjct: 1692 ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVT--VRVAVEDENDHAP 1749
Query: 448 EFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDS 507
F ++ + + +PE +P TL ML A D D+ A + + I GD G F LD S
Sbjct: 1750 TFGSAHLS-LEVPEGQDPQTL-TMLRASDPDV-GANGQLQYRILDGDPSGAFVLDLA--S 1804
Query: 508 GHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLV-ERVMPPPKLDQ 566
G + L E P+ ++ + + G P AT +TV V + P
Sbjct: 1805 G--EFGTMRPLDREVEPAFQLRIEARD-----GGQPALSATLLLTVTVLDANDHAPAFPV 1857
Query: 567 ESYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSL 623
+Y VP PAG+ LL +Q DP + + + L + G +E SGE+ TA +L
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAAL 1917
Query: 624 QGAQPGDTYTVLVEAQD-TDEPRLSASAPLVI-------HFLKAPPAPALTLAPVPSQYL 675
Q +YT V A D LS + + I H P +P P P
Sbjct: 1918 DREQ-CPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSF 1976
Query: 676 CTP 678
TP
Sbjct: 1977 STP 1979
Score = 143 bits (360), Expect = 7e-34
Identities = 165/556 (29%), Positives = 242/556 (43%), Gaps = 56/556 (10%)
Query: 61 SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEN 120
S + PF++ G + +T LD E+ YQLQ+ L H G + V V+D N
Sbjct: 2314 SPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQL-LAHDGPHE--GRANLTVLVEDVN 2370
Query: 121 DQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPA-QPSPDM 179
D P FSQ++Y+ L T PG L + A+DRD AN + +H+ S A P+
Sbjct: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG--ANGHISYHLASPADGFSVDPNN 2428
Query: 180 FQLEPRLGALALSPKGSTSLDHALERTYQ----------LLVQVKDMGDQASG----HQA 225
L +G +AL GS ++D LE + VQ++D D A H
Sbjct: 2429 GTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYR 2488
Query: 226 TATVEVSIIESTWVSLEPI-------HLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPG 278
A E ST ++LE H A + ++ + +V + ES PG
Sbjct: 2489 VAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII-SGNWGRVFQLEPRLAEAGESAGPG 2547
Query: 279 PFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPP 338
P A G L + LD E+ +Y L V A + ++ + + V V+D NDN P+
Sbjct: 2548 P---RALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTR 2604
Query: 339 RDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSG 398
V++PE +P G E+ + A DAD PG P+ V + + S +P F++D +SG
Sbjct: 2605 ASYRVTVPEDTPVGAELLHVEASDAD-PG-PHGLVRFTVSSGDPSG-----LFELDESSG 2657
Query: 399 SVTLG-VLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPI 457
++ L L L+V A D AGA + V + V D+NDH P F + +
Sbjct: 2658 TLRLAHALDCETQARHQLVVQAADPAGAH---FALAPVTIEVQDVNDHGPAFPLNLLS-T 2713
Query: 458 SLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERG-DTEGTFGLDWEPDSGHVRLRLCK 516
S+ E+ PGTLV L AID D RL +E G EG +G +R R+
Sbjct: 2714 SVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARV-- 2771
Query: 517 NLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLV--ERVMPPPKLDQESYEASVP 574
YE S ++V L A+ TV+VLV E P L ++ VP
Sbjct: 2772 PFDYEHTESFRLLVGAADAGNL-------SASVTVSVLVTGEDEYDPVFL-APAFHFQVP 2823
Query: 575 ISAPAGSFLLTIQPSD 590
A G L +Q +D
Sbjct: 2824 EGARRGHSLGHVQATD 2839
Score = 142 bits (359), Expect = 1e-33
Identities = 190/694 (27%), Positives = 279/694 (40%), Gaps = 91/694 (13%)
Query: 18 PKAQPAELSVEVPEN--YGGNFPLYLTK-LPLPREGAEGQIVLSGDSGKATEGPFAMDPD 74
P A +++VPE+ +G +PL + R G +G LSGD T F ++
Sbjct: 141 PAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY-ALSGDGAGET---FRLETR 196
Query: 75 SG-------FLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVK--DENDQVPH 125
G L+VT LDRE ++ Y LQ LE DG L+ V D ND P
Sbjct: 197 PGPDGTPVPELVVTGELDRENRSHYMLQ--LEAYDGGSPPRRAQALLDVTLLDINDHAPA 254
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F+Q+ Y A +S PG P L + ASD D N + + I + P F ++
Sbjct: 255 FNQSRYHAVVSESLAPGSPVLQVFASDAD--AGVNGAVTYEINRRQSEGDGP--FSIDAH 310
Query: 186 LGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSL---- 241
G L L LD R ++L+VQ +D G A TV V S+
Sbjct: 311 TGLLQL----ERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIF 366
Query: 242 -------------EPIHLAENLKVLYPHH----MAQVHWSGGDVHYHLESHPPGPFEVNA 284
P L + V P V GG+ H+ L + + V
Sbjct: 367 LSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLV-- 424
Query: 285 EGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPR----D 340
V R LDRE + Y L+V A +S A + V D NDN P + +
Sbjct: 425 ----CVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPE 480
Query: 341 PTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV 400
P +PE++ PG+ V R++A D D N V Y L G F +DPTSG +
Sbjct: 481 P---LPEVALPGSFVVRVTARDPDQ--GTNGQVTYSL-----APGAHTHWFSIDPTSGII 530
Query: 401 TLGV-LPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISL 459
T L L+V+A D G +S+ V VA+ D+ND+ P+F + SL
Sbjct: 531 TTAASLDYELEPQPQLIVVATD--GGLPPLASSATVSVALQDVNDNEPQFQRTFYN-ASL 587
Query: 460 PEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERG-DTEGTFGLDWEPDSGHVRLRLCKNL 518
PE +PGT +TA DAD P F L+ +++ G + G+ + SG V + L
Sbjct: 588 PEGTQPGTCFLQVTATDADSGP-FGLLSYSLGAGLGSSGSPPFRIDAHSGDV--CTTRTL 644
Query: 519 SYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTV---LVERVMPPPKLDQESYEASVPI 575
+ PS S V G G + V V L + PP+ Y AS+
Sbjct: 645 DRDQGPS--------SFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISA 696
Query: 576 SAPAGSFLLTIQPSDP----ISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDT 631
+P G+ +L ++ DP R L +S +++ SG + A L +
Sbjct: 697 QSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPL-ARRANSV 755
Query: 632 YTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPAL 665
+ + A+D + SA + I + P P +
Sbjct: 756 VQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
Score = 138 bits (347), Expect = 2e-32
Identities = 170/661 (25%), Positives = 269/661 (40%), Gaps = 66/661 (9%)
Query: 18 PKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGF 77
P Q E SV + EN L + P GA GQ+ G S ++ F++DPD+G
Sbjct: 1647 PTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES----FSLDPDTGV 1702
Query: 78 LLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSR 137
L RALDREEQ E L V + + V V V+DEND P F A +
Sbjct: 1703 LTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE 1762
Query: 138 GTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGST 197
G P L ASD D AN L++ IL P+ F L+ G
Sbjct: 1763 GQDPQ-TLTMLRASDPDV--GANGQLQYRILDGDPS----GAFVLDLASGEFGT----MR 1811
Query: 198 SLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIEST------WVSLEPIHLAENLK 251
LD +E +QL ++ +D G A AT + V+++++ V + + E++
Sbjct: 1812 PLDREVEPAFQLRIEARDGGQPAL--SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVP 1869
Query: 252 VLYPHHMAQVH----WSGGDVHYHLESHPPGPFEVN-AEGNLYVTRELDREAQAEYLLQV 306
Q H + G V Y+L + G F + + G L LDRE Y V
Sbjct: 1870 AGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSV 1929
Query: 307 RA-QNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSP----PGTEVTRLSAE 361
A + + + + + V D ND+ P P + +P P P + L AE
Sbjct: 1930 SAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAE 1989
Query: 362 DADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAG-QNILLLVLAM 420
D DA N+ ++Y+L P VD +G + + P+ G ++ +L ++A
Sbjct: 1990 DRDA--GANASILYRLAGTPPP------GTTVDSYTGEIRVARSPVALGPRDRVLFIVAT 2041
Query: 421 DLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLE 480
DL S+T + V + + P F + ++ E+ PGT + A+ A
Sbjct: 2042 DL--GRPARSATGVIIVGLQGEAERGPRFPRAS-SEATIRENAPPGTPIVSPRAVHAG-- 2096
Query: 481 PAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVG 540
+ ++I G+ +GTF + +P +G + +R + L +E +P +V+ +S
Sbjct: 2097 GTNGPITYSILSGNEKGTFSI--QPSTGAITVRSAEGLDFEVSPRLRLVLQAES------ 2148
Query: 541 PGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSD-------PIS 593
G T L + P+ + Y A +P S P LL ++ D IS
Sbjct: 2149 -GGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQIS 2207
Query: 594 RTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLV 653
+L S + G ++ +G + T L +T VL+ A D P L SA L
Sbjct: 2208 YSLAAS--QPARGLFHVDPTTGTITTTAILDREIWAETRLVLM-ATDRGSPALVGSATLT 2264
Query: 654 I 654
+
Sbjct: 2265 V 2265
Score = 137 bits (344), Expect = 5e-32
Identities = 161/577 (27%), Positives = 246/577 (42%), Gaps = 51/577 (8%)
Query: 66 EGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPH 125
+G F + +G L V R LDRE++AE+ L V Q + V V D ND+ P
Sbjct: 1589 DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT 1648
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F Q Y L PG L L A+D D AN + + S + F L+P
Sbjct: 1649 FQQQEYSVLLRENNPPGTSLLTLRATDPDV--GANGQVTY-------GGVSSESFSLDPD 1699
Query: 186 LGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIH 245
G L +LD + L V +D G T V V + H
Sbjct: 1700 TGVLTT----LRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAH 1755
Query: 246 LA-ENLKVLYPHHMAQVHWSGGDV-------HYHLESHPPGPFEVN-AEGNLYVTRELDR 296
L+ E + P + + S DV + L+ P G F ++ A G R LDR
Sbjct: 1756 LSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDR 1815
Query: 297 EAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVT 356
E + + L++ A++ +A L L V V+D ND+ P P +V +PE P GT +
Sbjct: 1816 EVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL 1875
Query: 357 RLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILL 415
+L A D DA N HV Y L + G G AF ++P+SG + T L +
Sbjct: 1876 QLQAHDPDA--GANGHVTYYLGA-----GTAG-AFLLEPSSGELRTAAALDREQCPSYTF 1927
Query: 416 LVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIG---PISLPEDVEPGTLVAML 472
V A+D A A G S+T V + V D+NDHAP F TS + P P P +A L
Sbjct: 1928 SVSAVDGAAA-GPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATL 1986
Query: 473 TAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVV 532
A D D ++ + + GT DS +R+ ++ P V+ +
Sbjct: 1987 RAEDRDAGANASIL-YRLAGTPPPGT-----TVDSYTGEIRVARS-PVALGPRDRVLFI- 2038
Query: 533 QSVAKLVGPGPGPGATATVTV-LVERVMPPPKLDQESYEASVPISAPAGSFLLTIQP--S 589
VA +G P AT + V L P+ + S EA++ +AP G+ +++ + +
Sbjct: 2039 --VATDLG-RPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA 2095
Query: 590 DPISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQG 625
+ + +S+++ +E G I+ +G + T +S +G
Sbjct: 2096 GGTNGPITYSILSGNEKGTFSIQPSTGAI-TVRSAEG 2131
Score = 132 bits (332), Expect = 1e-30
Identities = 173/583 (29%), Positives = 240/583 (41%), Gaps = 82/583 (14%)
Query: 50 GAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGP 109
G G++ S F + P +G + + LDRE+Q+ YQL V ++QDG G
Sbjct: 1135 GPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLV--QVQDG----GS 1188
Query: 110 QP------VLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDL 163
P V V V D ND P F QA S G+P ++ DR PGT + L
Sbjct: 1189 PPRSTTGTVHVAVLDLNDNSPTFLQA------SGAAGGGLP---IQVPDRVPPGTLVTTL 1239
Query: 164 RFHILSQAP--------AQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKD 215
+ + P ++F L P G L + L A Y L + D
Sbjct: 1240 QAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTA----APLIRAERPHYVLTLSAHD 1295
Query: 216 MGDQASGHQATATVEVSIIESTWVSLEPIHLAEN---------LKVLYPHHMAQVHWSG- 265
G A+ + V ++ S ++ P LAE L V + G
Sbjct: 1296 QGSPP--RSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGS 1353
Query: 266 ---------GDVHYHLE--SHPPGPFEVNA-EGNLYVTRELDREAQAEY-LLQVRAQNSH 312
G + Y L + P G F ++A G LY+ R LD EA + L VRA+
Sbjct: 1354 VAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPG 1413
Query: 313 GEDYAAPLELHVLVMDENDNVPICPPRDP-TVSIPELSPPGTEVTRLSAEDADAPGSPNS 371
G A L + V V DEN++ P RDP +++PE PG + A DAD PG PNS
Sbjct: 1414 GAG-ARLLRVQVQVQDENEHAPAF-ARDPLALALPENPEPGAALYTFRASDADGPG-PNS 1470
Query: 372 HVVYQLLSPEPEDGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAMDL-AGAEGGF 429
V Y+LL EP A ++D +G+++ L +LLLV A D A A
Sbjct: 1471 DVRYRLLRQEP----PVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRR 1526
Query: 430 SSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFA 489
++ V VTD ND+AP F + + LPED PG + A D DL A R+
Sbjct: 1527 AARVSARVFVTDENDNAPVFASP--SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRL 1584
Query: 490 IERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATA 549
GD G F L S L + + L E H + VV P AT
Sbjct: 1585 ASGGD--GHFRL----HSSTGALSVVRPLDREQRAEHVLTVVASDHG-----SPPRSATQ 1633
Query: 550 TVTVLVERVM-PPPKLDQESYEASVPISAPAGSFLLTIQPSDP 591
+TV V V P Q+ Y + + P G+ LLT++ +DP
Sbjct: 1634 VLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDP 1676
Score = 125 bits (313), Expect = 2e-28
Identities = 189/690 (27%), Positives = 276/690 (40%), Gaps = 101/690 (14%)
Query: 61 SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVL---WGPQPVLVHVK 117
SG G F++D SG L R LDRE + LE++ G + + V V +
Sbjct: 829 SGGDPRGLFSLDAVSGLLQTLRPLDRELLGPV---LELEVRAGSGVPPAFAVARVRVLLD 885
Query: 118 DENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSP 177
D ND P F L T PG P L A D D NS + F +L+
Sbjct: 886 DVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSG--VNSRVTFTLLAGGGGA--- 940
Query: 178 DMFQLEPRLGALAL----SPKGSTSLDHALE--------RT--YQLLVQVKDMGDQASGH 223
F ++P G + L P G + + LE RT ++L V V+D+G +
Sbjct: 941 --FTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAP 998
Query: 224 QATA-TVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESH-PPGPFE 281
+ + T V + T + + + GG + YHL + PF
Sbjct: 999 RFNSPTYRVDLPSGTTAGTQVLQVQAQAP------------DGGPITYHLAAEGASSPFG 1046
Query: 282 VNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYA---APLELHVLVMDENDNVPICP 337
+ + G L+V LDREAQ Y+L+V A + + + V ++++N++ P
Sbjct: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
Query: 338 PRDPT-VSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPT 396
DPT +++ E PPGT V R+ A D D+ PN + Y L + + +AF++ P
Sbjct: 1107 -EDPTFLAVAENQPPGTSVGRVFATDRDS--GPNGRLTYSL----QQLSEDSKAFRIHPQ 1159
Query: 397 SGSV-TLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIG 455
+G V TL L + LLV D G S+T V VAV D+ND++P F+ +
Sbjct: 1160 TGEVTTLQTLDREQQSSYQLLVQVQD--GGSPPRSTTGTVHVAVLDLNDNSPTFLQASGA 1217
Query: 456 -----PISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHV 510
PI +P+ V PGTLV L A D D E + + + G F L P SG +
Sbjct: 1218 AGGGLPIQVPDRVPPGTLVTTLQAKDPD-EGENGTILYTL-TGPGSELFSL--HPHSGEL 1273
Query: 511 RLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVL--VERVMPPPKLDQES 568
L A H V+ + S P V VL PPP L +
Sbjct: 1274 ---LTAAPLIRAERPHYVLTL--SAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERD 1328
Query: 569 YEASVPI--------SAPAGSFLLTIQPSDPIS-RTLRFSLVN--DSEGWLCIEKFSGEV 617
A VP+ GS L ++ +P L ++LV D EG ++ SG +
Sbjct: 1329 PAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRL 1388
Query: 618 HTAQSL--QGAQPGDTYTVLVEAQDTDEPRL----------SASAPLVIHFLKAPPAPAL 665
+ A+ L + P TV E RL + AP F + P A AL
Sbjct: 1389 YLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPA---FARDPLALAL 1445
Query: 666 TLAPVPSQYLCTPRQDHGLIVSGPSKDPDL 695
P P L T R GP + D+
Sbjct: 1446 PENPEPGAALYTFRASD---ADGPGPNSDV 1472
Score = 121 bits (303), Expect = 3e-27
Identities = 175/656 (26%), Positives = 262/656 (39%), Gaps = 78/656 (11%)
Query: 13 VPQALPKAQ-PAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAM 71
V +A P Q A +SV P++ G+F L EG EG LS
Sbjct: 375 VSEAAPPGQLVARISVSDPDD--GDFAHVNVSL----EGGEGHFALS-----------TQ 417
Query: 72 DPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIY 131
D + V R LDREE+ Y L+VT L ++HV D ND P F + +Y
Sbjct: 418 DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLY 477
Query: 132 RAR-LSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALA 190
R L PG + + A D D+ GT N + + + A F ++P G +
Sbjct: 478 RPEPLPEVALPGSFVVRVTARDPDQ-GT-NGQVTYSLAPGAHTH----WFSIDPTSGIIT 531
Query: 191 LSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENL 250
+ SLD+ LE QL+V D G AT +V + + + +L
Sbjct: 532 TA----ASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASL 587
Query: 251 K------VLYPHHMAQVHWSG--GDVHYHLE----SHPPGPFEVNAE-GNLYVTRELDRE 297
+ A SG G + Y L S PF ++A G++ TR LDR+
Sbjct: 588 PEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRD 647
Query: 298 AQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTR 357
Q G + + + V + DENDN P PR+ SI SPPGT V R
Sbjct: 648 -QGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLR 706
Query: 358 LSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLG-VLPLRAGQNILLL 416
L A D D + + Y +L+ G F +D SG +T+ L RA + L
Sbjct: 707 LRAHDPDQ--GSHGRLSYHILA-----GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLE 759
Query: 417 VLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAID 476
+ A D G + + V++++ P F Q S+PEDV PGT V ++ A +
Sbjct: 760 IGAEDGGGLQA--EPSARVDISIVPGTPTPPIFEQLQY-VFSVPEDVAPGTSVGIVQAHN 816
Query: 477 ADLEPAFRL--MDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAP-SHEVVVVVQ 533
P RL + ++ GD G F LD L P E++ V
Sbjct: 817 ----PPGRLAPVTLSLSGGDPRGLFSLD-----------AVSGLLQTLRPLDRELLGPVL 861
Query: 534 SVAKLVGPGPGPG-ATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQPSDP 591
+ G G P A A V VL++ V P +P + G+ + T++ DP
Sbjct: 862 ELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDP 921
Query: 592 ---ISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEP 644
++ + F+L+ G ++ +G V + L G G + + +EA+D P
Sbjct: 922 DSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPL-GPSGGPAHELELEARDGGSP 976
Score = 119 bits (298), Expect = 1e-26
Identities = 179/667 (26%), Positives = 273/667 (40%), Gaps = 86/667 (12%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREE 88
+PE+ PL + +G+ GQI S + + G F +DP +G + T LDRE
Sbjct: 2180 LPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREI 2239
Query: 89 QAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFL 148
AE +L + + L G + V V D ND P Q + R+S G +
Sbjct: 2240 WAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQV 2298
Query: 149 EASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQ 208
+D D + + +++LS + Q D F + G ++L+ G + Q
Sbjct: 2299 TGNDVD-----SGPVLWYVLSPSGPQ---DPFSVGRYGGRVSLT--GPLDFEQCDRYQLQ 2348
Query: 209 LL-------------VQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYP 255
LL V V+D+ D A + + +V ++E H +L
Sbjct: 2349 LLAHDGPHEGRANLTVLVEDVNDNAPAF-SQSLYQVMLLE---------HTPPGSAILSV 2398
Query: 256 HHMAQVHWSGGDVHYHLESHPPGPFEVNA-EGNLY-----VTRELDREAQAEYLLQVRAQ 309
+ + G + YHL S P F V+ G L+ V D + +L+ R
Sbjct: 2399 SATDRDSGANGHISYHLAS-PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457
Query: 310 NSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSP 369
+ G AA +HV + D+ND+ P V++ E PPG+ + L A DAD S
Sbjct: 2458 GAPGR--AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRS- 2514
Query: 370 NSHVVYQLLSPEPEDGVEGRAFQVDP--TSGSVTLGVLPLRAGQNILLLVLAMD------ 421
++ V Y ++S G GR FQ++P + G P G +LL L +
Sbjct: 2515 HAAVDYSIIS-----GNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYN 2569
Query: 422 --LAGAEGG---FSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAID 476
+A A+ G SS V V V D+ND+ P F T +++PED G + + A D
Sbjct: 2570 LTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVF-TRASYRVTVPEDTPVGAELLHVEASD 2628
Query: 477 ADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVA 536
AD P L+ F + GD G F LD SG LRL L E H++VV
Sbjct: 2629 ADPGP-HGLVRFTVSSGDPSGLFELD--ESSG--TLRLAHALDCETQARHQLVV------ 2677
Query: 537 KLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQPSDPISRT 595
+ P A A VT+ V+ V P SV + P G+ + T+ D +
Sbjct: 2678 QAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGA 2737
Query: 596 ---LRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGD-----TYTVLVEAQDTDEPRLS 647
LR+SL+ G E F+ T + L+ P D ++ +LV A D LS
Sbjct: 2738 FGRLRYSLLEAGPGPEGREAFALNSSTGE-LRARVPFDYEHTESFRLLVGAADAG--NLS 2794
Query: 648 ASAPLVI 654
AS + +
Sbjct: 2795 ASVTVSV 2801
Score = 112 bits (281), Expect = 1e-24
Identities = 178/679 (26%), Positives = 270/679 (39%), Gaps = 91/679 (13%)
Query: 6 LWLLCVSVPQALPKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKAT 65
L LL VP A +A +L ++ + G LP A +S G
Sbjct: 30 LLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGT-AAPLMYFISAQEGSGV 88
Query: 66 EGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPH 125
A+D SG + R LDRE++ Y+ T DG + V V V D ND P
Sbjct: 89 GTDLAIDEHSGVVRTARVLDREQRDRYRF--TAVTPDGATV----EVTVRVADINDHAPA 142
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F QA ++ T G + A D D + + LS + + F+LE R
Sbjct: 143 FPQARAALQVPEHTAFGTRYPLEPARDAD---AGRLGTQGYALS---GDGAGETFRLETR 196
Query: 186 LGALALSPKGST--------SLDHALERTYQLLVQVKDMGDQASGHQATATVEVSII--- 234
G P G+ LD Y L ++ D G + +A A ++V+++
Sbjct: 197 PG-----PDGTPVPELVVTGELDRENRSHYMLQLEAYDGG--SPPRRAQALLDVTLLDIN 249
Query: 235 -------ESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHL---ESHPPGPFEVNA 284
+S + ++ LA VL G V Y + +S GPF ++A
Sbjct: 250 DHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDA 309
Query: 285 E-GNLYVTRELDREAQA--EYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP----ICP 337
G L + R LD E + E ++Q R +H E +A + +H V D NDN P I
Sbjct: 310 HTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVH--VRDANDNQPSMTVIFL 367
Query: 338 PRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTS 397
D + + E +PPG V R+S D D +HV L +G EG F +
Sbjct: 368 SADGSPQVSEAAPPGQLVARISVSDPD--DGDFAHVNVSL------EGGEGH-FALSTQD 418
Query: 398 GSVTLGVLPLRAGQN----ILLLVLAMDLAG----AEGGFSSTCEVEVAVTDINDHAPEF 449
+ L + R + L V A D AE F + VTD+ND+AP F
Sbjct: 419 SVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAF------VLHVTDVNDNAPAF 472
Query: 450 ITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGH 509
P LPE PG+ V +TA D D + + +++ G F +D P SG
Sbjct: 473 DRQLYRPEPLPEVALPGSFVVRVTARDPD-QGTNGQVTYSLAPGAHTHWFSID--PTSGI 529
Query: 510 VRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQES 568
+ +L YE P +++VV G P ++ATV+V ++ V P+ +
Sbjct: 530 I--TTAASLDYELEPQPQLIVVATD-----GGLPPLASSATVSVALQDVNDNEPQFQRTF 582
Query: 569 YEASVPISAPAGSFLLTIQPSDP-------ISRTLRFSLVNDSEGWLCIEKFSGEVHTAQ 621
Y AS+P G+ L + +D +S +L L + I+ SG+V T +
Sbjct: 583 YNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTR 642
Query: 622 SLQGAQPGDTYTVLVEAQD 640
+L Q ++ V A D
Sbjct: 643 TLDRDQGPSSFDFTVTAVD 661
Score = 95.5 bits (236), Expect = 2e-19
Identities = 176/696 (25%), Positives = 263/696 (37%), Gaps = 105/696 (15%)
Query: 66 EGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPH 125
+GPF++D +G L + R LD E++ ++L V H G V VHV+D ND P
Sbjct: 302 DGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPS 361
Query: 126 ----FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQ 181
F A ++S PG + SD D+ A+ ++
Sbjct: 362 MTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNV-----------------S 404
Query: 182 LEPRLGALALSPKGST--------SLDHALERTYQLLVQVKDMGDQASGHQATATVEVSI 233
LE G ALS + S LD Y L V D G +A + V+
Sbjct: 405 LEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTD 464
Query: 234 IESTWVSLE-PIHLAENL-KVLYPHHMA-------QVHWSGGDVHYHLESHPPGP----F 280
+ + + ++ E L +V P + G V Y L PG F
Sbjct: 465 VNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSL---APGAHTHWF 521
Query: 281 EVNAEGNLYVT-RELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPR 339
++ + T LD E + + L V A + A+ + V + D NDN P
Sbjct: 522 SIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 581
Query: 340 DPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGS 399
S+PE + PGT +++A DAD+ P + Y L + G F++D SG
Sbjct: 582 FYNASLPEGTQPGTCFLQVTATDADS--GPFGLLSYSLGAGLGSSG--SPPFRIDAHSGD 637
Query: 400 V-TLGVLPLRAGQNIL-LLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPI 457
V T L G + V A+D GG S V+V ++D ND+ P+F +
Sbjct: 638 VCTTRTLDRDQGPSSFDFTVTAVD----GGGLKSMVYVKVFLSDENDNPPQFYPREYA-A 692
Query: 458 SLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKN 517
S+ PGT V L A D D RL + I G++ F LD + V L +
Sbjct: 693 SISAQSPPGTAVLRLRAHDPDQGSHGRL-SYHILAGNSPPLFTLDEQSGLLTVAWPLARR 751
Query: 518 LSYEAAPSHEVVVVVQSVAKL-VGPGPGPGATATVTVLVE-RVMP----PPKLDQESYEA 571
SV +L +G G G A + V+ ++P PP +Q Y
Sbjct: 752 --------------ANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVF 797
Query: 572 SVPISAPAGSFLLTIQPSDPISRTLRFSLV---NDSEGWLCIEKFSGEVHTAQSLQGAQP 628
SVP G+ + +Q +P R +L D G ++ SG + T + L
Sbjct: 798 SVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELL 857
Query: 629 GDTYTVLVEAQDTDEPRLSASAPLVI-----HFLKAPPAPALTLAPVPSQYLCTPRQDHG 683
G + V A P + + V+ A PAP T+ P+ TP
Sbjct: 858 GPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTP----- 912
Query: 684 LIVSGPSKDPD-----------LASGHGPYSFTLGP 708
I + + DPD LA G G +FT+ P
Sbjct: 913 -IYTLRALDPDSGVNSRVTFTLLAGGGG--AFTVDP 945
Score = 86.7 bits (213), Expect = 8e-17
Identities = 133/466 (28%), Positives = 202/466 (43%), Gaps = 42/466 (9%)
Query: 206 TYQLLVQVKDMGDQASGH-QATATVEVS--IIESTWVSLEPIHLAENLKVLYPHHMAQVH 262
T ++ V+V D+ D A QA A ++V T LEP A+ ++ + +
Sbjct: 126 TVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYA--LS 183
Query: 263 WSGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLEL 322
G + LE+ P GP + L VT ELDRE ++ Y+LQ+ A + A L
Sbjct: 184 GDGAGETFRLETRP-GP-DGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALL 241
Query: 323 HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEP 382
V ++D ND+ P + E PG+ V ++ A DADA N V Y++ +
Sbjct: 242 DVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADA--GVNGAVTYEINRRQS 299
Query: 383 E-DGVEGRAFQVDPTSGSVTLGVLPLRAGQNIL--LLVLAMDLAGAEGGFSSTCEVEVAV 439
E DG F +D +G + L PL Q + L+V A D GA S V V V
Sbjct: 300 EGDG----PFSIDAHTGLLQL-ERPLDFEQRRVHELVVQARD-GGAHPELGSAF-VTVHV 352
Query: 440 TDINDHAPE---FITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTE 496
D ND+ P S G + E PG LVA ++ D D + F ++ ++E G E
Sbjct: 353 RDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPD-DGDFAHVNVSLEGG--E 409
Query: 497 GTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVE 556
G F L + DS + + + L E ++ + V A G P A V + +
Sbjct: 410 GHFALSTQ-DSVIYLVCVARRLDREERDAYNLRV----TATDSGSPPLRAEAAFVLHVTD 464
Query: 557 RVMPPPKLDQESYEAS-VPISAPAGSFLLTIQPSDPISRT---LRFSLVNDSE-GWLCIE 611
P D++ Y +P A GSF++ + DP T + +SL + W I+
Sbjct: 465 VNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSID 524
Query: 612 KFSGEVHTAQSLQ---GAQPGDTYTVLVEAQDTDEPRLSASAPLVI 654
SG + TA SL QP ++V A D P L++SA + +
Sbjct: 525 PTSGIITTAASLDYELEPQP----QLIVVATDGGLPPLASSATVSV 566
Score = 85.5 bits (210), Expect = 2e-16
Identities = 168/699 (24%), Positives = 261/699 (37%), Gaps = 103/699 (14%)
Query: 18 PKAQPAELSVEVPENYGGNFPLYLTKLPL--PREGAEGQI---VLSGDSGKATEGPFAMD 72
P A LS+EVPE G P LT L P GA GQ+ +L GD G F +D
Sbjct: 1749 PTFGSAHLSLEVPE---GQDPQTLTMLRASDPDVGANGQLQYRILDGDPS----GAFVLD 1801
Query: 73 PDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVL-------VHVKDENDQVPH 125
SG R LDRE + +QL++ E +DG QP L V V D ND P
Sbjct: 1802 LASGEFGTMRPLDREVEPAFQLRI--EARDGG-----QPALSATLLLTVTVLDANDHAPA 1854
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F Y + G L L+A D D AN + +++ + F LEP
Sbjct: 1855 FPVPAYSVEVPEDVPAGTLLLQLQAHDPD--AGANGHVTYYL-----GAGTAGAFLLEPS 1907
Query: 186 LGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIH 245
G L + + +LD +Y V D A+ + TV V+I P
Sbjct: 1908 SGEL----RTAAALDREQCPSYTFSVSAVD---GAAAGPLSTTVSVTITVRDVNDHAPTF 1960
Query: 246 LAENLKVLYPHH--------------MAQVHWSGGD--VHYHLESHPPGPFEVNA-EGNL 288
L++ P A+ +G + + Y L PP V++ G +
Sbjct: 1961 PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEI 2020
Query: 289 YVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPEL 348
V R + +L + A + +A + V + E + P P +I E
Sbjct: 2021 RVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIREN 2080
Query: 349 SPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLR 408
+PPGT + A A G N + Y +LS G E F + P++G++T+ R
Sbjct: 2081 APPGTPIVSPRAVHA---GGTNGPITYSILS-----GNEKGTFSIQPSTGAITV-----R 2127
Query: 409 AGQNILLLV---LAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEP 465
+ + + V L + L GG + + + + D ND+AP F+ LPE
Sbjct: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAF-LPESRPL 2186
Query: 466 GTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPS 525
+ + A D D ++ G F +D P +G + + A
Sbjct: 2187 EGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVD--PTTGTITTTAILDREIWAETR 2244
Query: 526 HEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLT 585
++ + LVG +AT+TV+V + +E V A GS +
Sbjct: 2245 LVLMATDRGSPALVG-------SATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQ 2297
Query: 586 IQPSDPISRTLRFSLVNDS--EGWLCIEKFSGEVHTAQSLQGAQPGDTY----------- 632
+ +D S + + +++ S + + ++ G V L Q D Y
Sbjct: 2298 VTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQC-DRYQLQLLAHDGPH 2356
Query: 633 ------TVLVEAQDTDEPRLSASAPLVIHFLKAPPAPAL 665
TVLVE + + P S S V+ PP A+
Sbjct: 2357 EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAI 2395
Score = 77.4 bits (189), Expect = 5e-14
Identities = 122/455 (26%), Positives = 178/455 (39%), Gaps = 71/455 (15%)
Query: 286 GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSI 345
G + R LDRE + Y + A +E+ V V D ND+ P P + +
Sbjct: 99 GVVRTARVLDREQRDRYRFTAVTPDG------ATVEVTVRVADINDHAPAFPQARAALQV 152
Query: 346 PELSPPGTEVTRLSAEDADAP---------GSPNSHVVYQLLSPEPEDGVEGRAFQVDPT 396
PE + GT A DADA + ++L + DG P
Sbjct: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGT--------PV 204
Query: 397 SGSVTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGP 456
V G L + +L + A D G + ++V + DINDHAP F S+
Sbjct: 205 PELVVTGELDRENRSHYMLQLEAYD--GGSPPRRAQALLDVTLLDINDHAPAFNQSRYHA 262
Query: 457 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCK 516
+ + E + PG+ V + A DAD + + I R +EG + +G L+L +
Sbjct: 263 V-VSESLAPGSPVLQVFASDAD-AGVNGAVTYEINRRQSEGDGPFSIDAHTG--LLQLER 318
Query: 517 NLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERV---MPPPKLDQESYEASV 573
L +E HE+VV A+ G P G +A VTV V P + S + S
Sbjct: 319 PLDFEQRRVHELVV----QARDGGAHPELG-SAFVTVHVRDANDNQPSMTVIFLSADGSP 373
Query: 574 PIS--APAGSFLLTIQPSDPISRTLRFSLVNDS-EGWLCIEKFSGEVHTAQSLQGA---- 626
+S AP G + I SDP F+ VN S EG GE H A S Q +
Sbjct: 374 QVSEAAPPGQLVARISVSDPDDGD--FAHVNVSLEG--------GEGHFALSTQDSVIYL 423
Query: 627 ---------QPGDTYTVLVEAQDTDEPRLSASAPLVIHFL----KAPPAPALTLAPVPSQ 673
+ D Y + V A D+ P L A A V+H AP P P
Sbjct: 424 VCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLP 483
Query: 674 YLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGP 708
+ P +V ++DPD + +G +++L P
Sbjct: 484 EVALP---GSFVVRVTARDPDQGT-NGQVTYSLAP 514
Score = 36.2 bits (82), Expect = 0.13
Identities = 57/242 (23%), Positives = 91/242 (37%), Gaps = 40/242 (16%)
Query: 22 PAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIV-----LSGDSG----------KATE 66
P + V+ ++G FPL L + G +V + GD+G +A
Sbjct: 2691 PVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGP 2750
Query: 67 GP-----FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 121
GP FA++ +G L D E ++L V D L V V V E++
Sbjct: 2751 GPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAA--DAGNLSASVTVSVLVTGEDE 2808
Query: 122 QVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQ 181
P F + ++ G R G ++A+D D G A+ + + + + +P F
Sbjct: 2809 YDPVFLAPAFHFQVPEGARRGHSLGHVQATDED--GGADGLVLYSLATSSP------YFG 2860
Query: 182 LEPRLGALAL-----SPKGSTSLDHALERT-----YQLLVQVKDMGDQASGHQATATVEV 231
+ GAL L +P T+ RT +L ++V G AT V V
Sbjct: 2861 INQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920
Query: 232 SI 233
I
Sbjct: 2921 DI 2922
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 167 bits (422), Expect = 5e-41
Identities = 173/635 (27%), Positives = 277/635 (43%), Gaps = 46/635 (7%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQIV--LSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
VPEN + P G G++V L+ + F++DP SG + ALDR
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 87 EEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFL 146
E + L+VT + L V V V D ND P F QA YR L G P L
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
Query: 147 FLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERT 206
L A+D D P AN RF + A + F+++PR G ++ S + +D +
Sbjct: 454 QLRATDGDAPPNANLRYRF-VGPPAARAAAAAAFEIDPRSGLISTSGR----VDREHMES 508
Query: 207 YQLLVQVKDMGDQASGHQATATVEVSIIESTWVS---LEPIHLAENLKVLYPHHMA---- 259
Y+L+V+ D G + AT V +++++ + E ++A+ + + PH +
Sbjct: 509 YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVT 568
Query: 260 ---QVHWSGGDVHYHLES-HPPGPFEVNA-EGNLYVTRELDREAQAEYLLQVRAQNSHGE 314
+ + G VHY++ S + G F +++ G + V LD EA+ EY L++RAQ++
Sbjct: 569 ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRP 628
Query: 315 DYAAPLEL-HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHV 373
+ L + V+D ND++PI VS+ E +P G V + A DAD N+ +
Sbjct: 629 PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD--HGENARL 686
Query: 374 VYQLLSPEPEDGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAMDLAGAEGGFSST 432
Y L P+ F ++ +G V++ G L + ++ V A D S++
Sbjct: 687 EYSLTGVAPD-----TPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP--LSAS 739
Query: 433 CEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIER 492
V V V D+ND+ PEF T + + L ED GT V +TA+D D A + + I
Sbjct: 740 ASVTVTVLDVNDNRPEF-TMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA---ISYQITG 795
Query: 493 GDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVT 552
G+T F + + G V L L L Y+ ++V+ A
Sbjct: 796 GNTRNRFAISTQGGVGLVTLAL--PLDYKQERYFKLVLTASDRAL-------HDHCYVHI 846
Query: 553 VLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPS-DPISRTLRFS-LVNDSEGWLCI 610
+ + P Y SV P GS ++ I S D + R + L+ D+ I
Sbjct: 847 NITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRI 906
Query: 611 EKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPR 645
+ SG + T Q+ + TYT+ + A+D P+
Sbjct: 907 DADSGAI-TLQAPLDYEDQVTYTLAITARDNGIPQ 940
Score = 110 bits (275), Expect = 5e-24
Identities = 168/677 (24%), Positives = 279/677 (41%), Gaps = 72/677 (10%)
Query: 56 VLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVL-V 114
++SG+S G FA+D +G + V LD E + EY L++ + L + +
Sbjct: 584 IISGNS----RGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASI 639
Query: 115 HVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQ 174
V D ND +P F ++ + G + ++A D D N+ L + + AP
Sbjct: 640 QVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG--ENARLEYSLTGVAPDT 697
Query: 175 PSPDMFQLEPRLGALALS-PKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSI 233
P F + G +++S P S++H Y V+ +D G A+ TV V
Sbjct: 698 P----FVINSATGWVSVSGPLDRESVEH-----YFFGVEARDHGSPPLSASASVTVTVLD 748
Query: 234 IESTW--VSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGP-----FEVNAEG 286
+ +++ HL N + V D + + G F ++ +G
Sbjct: 749 VNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQG 808
Query: 287 NLYVTR---ELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTV 343
+ + LD + + + L + A + D+ +H+ + D N + P+ +V
Sbjct: 809 GVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY---VHINITDANTHRPVFQSAHYSV 865
Query: 344 SIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLG 403
S+ E P G+ + +SA D D N+ + Y L P+ F++D SG++TL
Sbjct: 866 SVNEDRPMGSTIVVISASDDDV--GENARITYLLEDNLPQ-------FRIDADSGAITLQ 916
Query: 404 VLPLRAGQNILLLVLAMDLAGAEGGF---SSTCEVEVAVTDINDHAPEFITSQIGPISLP 460
PL + + + + G + T VEV V D+ND+AP+F+ S + +
Sbjct: 917 A-PLDYEDQV---TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGL-VS 971
Query: 461 EDVEPGTLVAMLTAIDADLEPAFRLMDFAIERG-DTEGTFGLDWEPDSGHVRLRLCKNLS 519
ED P T V ++A D D R + + + G D +G F + EP SG V R + L
Sbjct: 972 EDAPPFTSVLQISATDRDAHANGR-VQYTFQNGEDGDGDFTI--EPTSGIV--RTVRRLD 1026
Query: 520 YEAAPSHEVVVVVQSVAKLVGPGPGPGAT-ATVTVLVERVMP-PPKLDQESYEASVPISA 577
EA V V + A V G P T ++ V+V+ V P E +E V ++
Sbjct: 1027 REA------VSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENS 1080
Query: 578 PAGSFLLTIQPSDPISRTLRFSLVNDSEG----WLCIEKFSGEVHTAQSLQGAQPGDTYT 633
GS + I DP + EG ++ FSGE+ TA + Y
Sbjct: 1081 IVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYEARQEYV 1139
Query: 634 VLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQD---HGLIVSGPS 690
++V+A T P +S + V + +P L + + R D G+I P+
Sbjct: 1140 IVVQA--TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA 1197
Query: 691 KDPDLASGHGPYSFTLG 707
DPD+ S H YSF G
Sbjct: 1198 YDPDV-SDHLFYSFERG 1213
Score = 107 bits (267), Expect = 5e-23
Identities = 108/394 (27%), Positives = 176/394 (44%), Gaps = 38/394 (9%)
Query: 280 FEVNAEGNLYVTRE-LDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPP 338
F ++ + L T LDRE+ + L+V AQ+ +A + V V D ND+ P+
Sbjct: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 339 RDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSG 398
++ E G + +L A D DAP PN+++ Y+ + P AF++DP SG
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAP--PNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
Query: 399 SV-TLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPI 457
+ T G + ++ L+V A D G S+T V + V D ND+AP+F +
Sbjct: 494 LISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY-VA 552
Query: 458 SLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKN 517
+ EDV P T+V +TA D D + A L+ + I G++ G F +D S +++
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKD-ANGLVHYNIISGNSRGHFAID----SLTGEIQVVAP 607
Query: 518 LSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMPP-PKLDQESYEASVPIS 576
L +EA + + + Q G P T ++ V + P ++ SV +
Sbjct: 608 LDFEAEREYALRIRAQDA----GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLEN 663
Query: 577 APAGSFLLTIQPSDPI---SRTLRFSL----------VNDSEGWLCIEKFSGEVHTAQSL 623
AP G ++ IQ D + L +SL +N + GW+ + SG +
Sbjct: 664 APLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSV---SGPLDR---- 716
Query: 624 QGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFL 657
+ + Y VEA+D P LSASA + + L
Sbjct: 717 ---ESVEHYFFGVEARDHGSPPLSASASVTVTVL 747
Score = 100 bits (250), Expect = 4e-21
Identities = 110/449 (24%), Positives = 181/449 (40%), Gaps = 43/449 (9%)
Query: 61 SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEN 120
+G T FA+ G LVT AL + + E ++ L D L V +++ D N
Sbjct: 794 TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD-RALHDHCYVHINITDAN 852
Query: 121 DQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMF 180
P F A Y ++ G + + ASD D+ G N+ + + + P F
Sbjct: 853 THRPVFQSAHYSVSVNEDRPMGSTIVVISASD-DDVGE-NARITYLLEDNLP------QF 904
Query: 181 QLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVS 240
+++ GA+ L LD+ + TY L + +D G V V+ +
Sbjct: 905 RIDADSGAITLQ----APLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
Query: 241 LEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGN-----------LY 289
H + P + + S D H F+ +G+ +
Sbjct: 961 FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR 1020
Query: 290 VTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELS 349
R LDREA + Y L A + P+ + V+V D NDN P+ P + V + E S
Sbjct: 1021 TVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENS 1080
Query: 350 PPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGV-LPLR 408
G+ V +++A D D PN+H++YQ++ +G FQ+D SG +T + L
Sbjct: 1081 IVGSVVAQITAVDPDE--GPNAHIMYQIV-----EGNIPELFQMDIFSGELTALIDLDYE 1133
Query: 409 AGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQI---GPISLPEDVEP 465
A Q +++V A S V V + D ND++P QI +S D P
Sbjct: 1134 ARQEYVIVVQA-----TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFP 1188
Query: 466 GTLVAMLTAIDADLEPAFRLMDFAIERGD 494
++ + A D D+ + ++ ERG+
Sbjct: 1189 SGIIGRIPAYDPDVSDH---LFYSFERGN 1214
Score = 74.7 bits (182), Expect = 3e-13
Identities = 84/328 (25%), Positives = 134/328 (40%), Gaps = 23/328 (7%)
Query: 334 PICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQV 393
P P + +PE GT V R+ A+D DA +VY L + +E F +
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDA--GEAGRLVYSLAALMNSRSLE--LFSI 378
Query: 394 DPTSGSV-TLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITS 452
DP SG + T L + + L V A D S+T V V V D NDH+P F +
Sbjct: 379 DPQSGLIRTAAALDRESMERHYLRVTAQDHGSPR--LSATTMVAVTVADRNDHSPVFEQA 436
Query: 453 QIGPISLPEDVEPGTLVAMLTAIDADLEP----AFRLMDFAIERGDTEGTFGLDWEPDSG 508
Q +L E+VE G + L A D D P +R + R F +D P SG
Sbjct: 437 QYRE-TLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID--PRSG 493
Query: 509 HVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMPPPKLDQES 568
+ + E S+E+VV + PGP +++ P+ ++
Sbjct: 494 --LISTSGRVDREHMESYELVVEASDQGQ--EPGPRSATVRVHITVLDENDNAPQFSEKR 549
Query: 569 YEASVPISAPAGSFLLTIQPSD---PISRTLRFSLVN-DSEGWLCIEKFSGEVHTAQSLQ 624
Y A V + +L + +D + + +++++ +S G I+ +GE+ L
Sbjct: 550 YVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLD 609
Query: 625 GAQPGDTYTVLVEAQDTDEPRLSASAPL 652
+ Y + + AQD P LS + L
Sbjct: 610 -FEAEREYALRIRAQDAGRPPLSNNTGL 636
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/209 (23%), Positives = 92/209 (44%), Gaps = 19/209 (9%)
Query: 51 AEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQ 110
A G++ + +G+ +G F ++P SG + R LDRE + Y+L + L P
Sbjct: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPV 1051
Query: 111 PVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQ 170
+ V V+D ND P F + R+ + G + A D DE A HI+ Q
Sbjct: 1052 SIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNA------HIMYQ 1105
Query: 171 APAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVE 230
P++FQ++ G L LD+ + Y ++VQ ++ + ATV
Sbjct: 1106 IVEGNIPELFQMDIFSGELT----ALIDLDYEARQEYVIVVQA-----TSAPLVSRATVH 1156
Query: 231 VSIIESTWVSLEPIHLAENLKVLYPHHMA 259
V +++ + + N ++L+ ++++
Sbjct: 1157 VRLVDQN----DNSPVLNNFQILFNNYVS 1181
Score = 34.3 bits (77), Expect = 0.49
Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 8/100 (8%)
Query: 562 PKLDQESYEASVPISAPAGSFLLTIQPSDP-------ISRTLRFSLVNDSEGWLCIEKFS 614
P+ Q +Y+ VP + AG+ +L + DP + +L + + S I+ S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 615 GEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVI 654
G + TA +L + + + + V AQD PRLSA+ + +
Sbjct: 383 GLIRTAAALD-RESMERHYLRVTAQDHGSPRLSATTMVAV 421
>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
Length = 832
Score = 156 bits (395), Expect = 7e-38
Identities = 144/541 (26%), Positives = 242/541 (44%), Gaps = 31/541 (5%)
Query: 281 EVNAEGNLYVTRELDREAQAEYLLQVRA-QNSHGEDYAAPLELHVLVMDENDNVPICPPR 339
E + G +YV R +DRE + + + S G+ L ++ + D ND+ P P +
Sbjct: 109 EDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEK 168
Query: 340 DPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGS 399
+ +++ E G + ++ A D D +PNS V+Y L+S P ++ F+VD SG
Sbjct: 169 EFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPL--LKESGFRVDRLSGE 226
Query: 400 VTL-GVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPIS 458
+ L G L LL+ A D E SST V V V + N+H P F T + +
Sbjct: 227 IRLSGCLDYETAPQFTLLIRARDC--GEPSLSSTTTVHVDVQEGNNHRPAF-TQENYKVQ 283
Query: 459 LPED-VEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKN 517
+PE G L ++ D+ A+R F I G+ EG F + +P++ L + K
Sbjct: 284 IPEGRASQGVLRLLVQDRDSPFTSAWR-AKFNILHGNEEGHFDISTDPETNEGILNVIKP 342
Query: 518 LSYEAAPSHEVVVVVQSVAKLV-------GPGPGPGATATVTVLVERVMPPPKLDQESYE 570
L YE P+ +++VV++ +LV P A+ATV+V V PP +S+
Sbjct: 343 LDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFI 402
Query: 571 ASVPISAPAGSFLLTIQPSDPISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQP-- 628
+ A G+ L T DP S+ +R+ LV+D W+ ++K SG V T + + P
Sbjct: 403 VNKEEGARPGTLLGTFNAMDPDSQ-IRYELVHDPANWVSVDKNSGVVITVEPIDRESPHV 461
Query: 629 -GDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYL--CTPRQDHGLI 685
Y +++ A D P +A+ L++ FL TL P S+Y+ C L
Sbjct: 462 NNSFYVIIIHAVDDGFPPQTATGTLML-FLSDINDNVPTLRP-RSRYMEVCESAVHEPLH 519
Query: 686 VSGPSKDPDLASGHGPYSFTLGPN-PTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPV 744
+ ++DPDL P++F L + W+L N + L L + +++P+
Sbjct: 520 IE--AEDPDLEPFSDPFTFELDNTWGNAEDTWKLGR-NWGQSVELLTLRSLPRGNYLVPL 576
Query: 745 VVSHNAQMWQ-LLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIGIFLIL 803
+ + Q V V +C C C+ G+ + A+ + VA+ + L+
Sbjct: 577 FIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGL--HVGALFPVCAAFVALAVALLF 634
Query: 804 I 804
+
Sbjct: 635 L 635
Score = 75.1 bits (183), Expect = 2e-13
Identities = 115/474 (24%), Positives = 192/474 (40%), Gaps = 70/474 (14%)
Query: 72 DPDSGFLLVTRALDREEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAI 130
D ++G + V R +DRE + + +E G ++ + + D ND P F +
Sbjct: 110 DHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKE 169
Query: 131 YRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALA 190
+ + G P + A D DE T NS + + ++SQ P F+++ G +
Sbjct: 170 FNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESG-FRVDRLSGEIR 228
Query: 191 LSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENL 250
L S LD+ + LL++ +D G+ + +T TV V + E + P EN
Sbjct: 229 L----SGCLDYETAPQFTLLIRARDCGEPSL--SSTTTVHVDVQEGN--NHRPAFTQENY 280
Query: 251 KVLYPHHMA-------------QVHWSGGDVHYH-LESHPPGPFEVNA-----EGNLYVT 291
KV P A S ++ L + G F+++ EG L V
Sbjct: 281 KVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVI 340
Query: 292 RELDREAQAEYLLQVRAQNSH------------GEDYAAPLELHVLVMDENDNVPICPPR 339
+ LD E + L + +N AA + V V D ND P P+
Sbjct: 341 KPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDAND-PPAFHPQ 399
Query: 340 DPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGS 399
V+ E + PGT + +A D P+S + Y+L+ +P + V VD SG
Sbjct: 400 SFIVNKEEGARPGTLLGTFNAMD------PDSQIRYELVH-DPANWV-----SVDKNSG- 446
Query: 400 VTLGVLPL-RAGQNILLLVLAMDLAGAEGGF---SSTCEVEVAVTDINDHAPEFITSQIG 455
V + V P+ R ++ + + + GF ++T + + ++DIND+ P +
Sbjct: 447 VVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVP-----TLR 501
Query: 456 PISLPEDVEPGTLVAML--TAIDADLEPAFRLMDFAIER--GDTEGTF--GLDW 503
P S +V + L A D DLEP F ++ G+ E T+ G +W
Sbjct: 502 PRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNW 555
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 154 bits (390), Expect = 2e-37
Identities = 176/641 (27%), Positives = 282/641 (43%), Gaps = 58/641 (9%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQ 128
F++ G + +T LDREE + Y L V + L V+V V D ND P F+Q
Sbjct: 2097 FSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQ 2156
Query: 129 AIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGA 188
A+Y+ ++ T G + + A+D DE GT N +R+ I++ Q F+++ GA
Sbjct: 2157 ALYKVEINENTLTGTDIIQVFAADGDE-GT-NGQVRYGIVNGNTNQE----FRIDSVTGA 2210
Query: 189 LALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIEST------WVSLE 242
+ ++ LD TY L VQ D G ++ T+TV + +++ +S
Sbjct: 2211 ITVAKP----LDREKTPTYHLTVQATDRG--STPRTDTSTVSIVLLDINDFVPVFELSPY 2264
Query: 243 PIHLAENLKVLYPHHMAQV------HWSGGDVHYHL-ESHPPGPFEVNAEGNLYVTRELD 295
+++ ENL L P + QV S + Y L + F ++A G L VT+ LD
Sbjct: 2265 SVNVPENLGTL-PRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLD 2323
Query: 296 REAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEV 355
RE + ++L + A +S ++V+V D NDNVP + +IPE +P GT+V
Sbjct: 2324 RETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDV 2383
Query: 356 TRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILL 415
++A DADA + + V +++ + F ++P++G + L R ++
Sbjct: 2384 LLVNASDADA----SKNAVIRIIGGNSQ-------FTINPSTGQIITSALLDRETKDNYT 2432
Query: 416 LVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGP--ISLPEDVEPGTLVAMLT 473
LV+ AG+ SS+ V V VTD+ND+ P F Q P +P PG+ V +T
Sbjct: 2433 LVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRF---QHHPYVTHIPSPTLPGSFVFAVT 2489
Query: 474 AIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQ 533
DAD+ P L +++ ++E F +D P G + A P + V
Sbjct: 2490 VTDADIGPNSEL-HYSLSGRNSE-KFHID--PLRGAI---------MAAGPLNGASEVTF 2536
Query: 534 SVAKLVGPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPIS 593
SV G + TVTV PK+ + P + P S + TI S
Sbjct: 2537 SVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRG 2596
Query: 594 RTLRFSLVNDSEG-WLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPL 652
+ + + + + G I++ +G+V +Q L + Y V +EA+D P S+ L
Sbjct: 2597 EPMSYYIASGNLGNTFQIDQLTGQVSISQPLD-FEKIQKYVVWIEARDGGFPPFSSYEKL 2655
Query: 653 VIHFLKA-PPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKD 692
I L AP P S+ L L VS KD
Sbjct: 2656 DITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKD 2696
Score = 134 bits (337), Expect = 3e-31
Identities = 164/637 (25%), Positives = 270/637 (42%), Gaps = 75/637 (11%)
Query: 55 IVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLV 114
++ +GD +G FA++ +G L +DREEQ+ YQL+V + G + G V +
Sbjct: 829 LITTGDQ----KGMFAINQVTGQLTTANVIDREEQSFYQLKV---VASGGTVTGDTMVNI 881
Query: 115 HVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQ 174
VKD ND PHF QAI + + G +A D DE + + + L Q P
Sbjct: 882 TVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDE---GVNGMVLYSLKQNPK- 937
Query: 175 PSPDMFQLEPRLGALALSPKGSTSLD-HALERTYQLLVQVKDMGDQASGHQATATVEVSI 233
++F + + G ++L LD HA +YQ+ + DMG TV V
Sbjct: 938 ---NLFAINEKNGTISLLGP----LDVHA--GSYQIEILASDMGVPQLSSSVILTVYVHD 988
Query: 234 I------------ESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHL-ESHPPGPF 280
+ E T EP+ N + + + G++ Y + E + F
Sbjct: 989 VNDNSPVFDQLSYEVTLSESEPV----NSRFFKVQASDKDSGANGEIAYTIAEGNTGDAF 1044
Query: 281 EVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRD 340
+ +G LY+ ELDRE Q Y+L V A + E +A + + V++ D NDN P+ +
Sbjct: 1045 GIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTN 1104
Query: 341 PTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV 400
T E G+ V ++SA D D PN V Y +P+ F++ SG +
Sbjct: 1105 YTFYFEEEQRAGSFVGKVSAVDKDF--GPNGEVRYSFEMVQPD-------FELHAISGEI 1155
Query: 401 T------LGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQI 454
T L R G + + G V V + DIND+AP+F+
Sbjct: 1156 TNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFL-KDF 1214
Query: 455 GPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRL 514
++ E T V ++A D D E L+ ++I +G+ E F +D SG V L
Sbjct: 1215 YQATISESAANLTQVLRVSASDVD-EGNNGLIHYSIIKGNEERQFAID--STSGQV--TL 1269
Query: 515 CKNLSYEAAPSHEVVVVVQSVAKLVGPGPGP-GATATVTV-LVERVMPPPKLDQESYEAS 572
L YEA P++ +V+ + V G P +T T+ + +++ P + +
Sbjct: 1270 IGKLDYEATPAYSLVI------QAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVD 1323
Query: 573 VPISAPAGSFLLTIQPSDPIS---RTLRFSLV-NDSEGWLCIEKFSGEVHTAQSLQGAQP 628
V + G + ++ +D S L +S+ ++ G I +G + A+ L +
Sbjct: 1324 VLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLD-FET 1382
Query: 629 GDTYTVLVEAQDTDEPRLSASAPLVIH---FLKAPPA 662
Y + + A+D P S++ +VIH F PP+
Sbjct: 1383 QSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPS 1419
Score = 123 bits (309), Expect = 6e-28
Identities = 174/677 (25%), Positives = 264/677 (38%), Gaps = 52/677 (7%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQ-VTLEMQDGHVLWGPQPVLVHVKDENDQVPHFS 127
FA++ +G L T +DRE + V L + P V V V+D ND P F
Sbjct: 81 FAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTY----PTEVRVLVRDLNDNAPVFP 136
Query: 128 QAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLG 187
+ G + A+D D + I+ A L P
Sbjct: 137 DPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGE 196
Query: 188 ALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSII--------ESTWV 239
L LD + YQLLV+V+D G+ V V I S +
Sbjct: 197 GAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQ 256
Query: 240 SLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRE-LDREA 298
+ P VL + D+ Y L+ PF+++ E L RE LD EA
Sbjct: 257 AGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGT-PFQMDPETGLITVREPLDFEA 315
Query: 299 QAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPIC-----PPRDPTVSIPELSPPGT 353
+ +Y L V+A + E + ++D NDN P+ P S+ E + GT
Sbjct: 316 RRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGT 375
Query: 354 EVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNI 413
V L+ DAD+P + N ++ Q+L + E ++ +V S L +
Sbjct: 376 VVALLTVTDADSPAA-NGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSY 434
Query: 414 LLLVLAMDLAGAEGGF-----SSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTL 468
L V D GA G SS + + V DINDH P F + Q+ ++L E+ PG+
Sbjct: 435 NLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVF-SQQVYRVNLSEEAPPGSY 493
Query: 469 VAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEV 528
V+ ++A D D L ++I G+ G F + SG V L E A
Sbjct: 494 VSGISATDGDSGLNANLR-YSIVSGNGLGWFHI--SEHSGLVTTGSSGGLDRELASQ--- 547
Query: 529 VVVVQSVAKLVGPGPGPGATATVTVLVERVMPPPKLDQ-ESYEASVPISAPAGSFLLTIQ 587
+V+ A+ G P V L++ P Q E Y+ SV +AP G+ LL ++
Sbjct: 548 -IVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLR 606
Query: 588 PSD---PISRTLRFSL--VNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTD 642
+D + T+RFSL ++ SG + T SL + Y++LV A D
Sbjct: 607 ATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQA-FYSLLVLATDLG 665
Query: 643 EPRLSASAPLVIHFLKAPPAPALTLAPV--PSQYLCTPRQDH---GLIVSGPSKDPDL-A 696
P S+ A + + L +PV P QY +++ I + + DPDL
Sbjct: 666 SPPQSSMARINVSLLDINDN-----SPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGT 720
Query: 697 SGHGPYSFTLGPNPTVQ 713
+G YS + G Q
Sbjct: 721 NGTVKYSISAGDRSRFQ 737
Score = 120 bits (300), Expect = 7e-27
Identities = 159/649 (24%), Positives = 271/649 (41%), Gaps = 73/649 (11%)
Query: 26 SVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALD 85
SV V EN+ ++ K P EG G ++ S + + FA++ +G + + LD
Sbjct: 899 SVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYS--LKQNPKNLFAINEKNGTISLLGPLD 956
Query: 86 REEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
YQ+++ L + V+V D ND P F Q Y LS F
Sbjct: 957 -VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRF 1015
Query: 146 LFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER 205
++ASD+D AN ++ + I + D F + P G L + + LD L+
Sbjct: 1016 FKVQASDKD--SGANGEIAYTIAE----GNTGDAFGIFPD-GQLYI----KSELDRELQD 1064
Query: 206 TYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSG 265
Y L+V D + +ATV V++I P+ + N + + G
Sbjct: 1065 RYVLMVVASDRAVE----PLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVG 1120
Query: 266 ------------GDVHYHLESHPPGPFEVNA-EGNLYVTRELDREA------QAEYLLQV 306
G+V Y E P FE++A G + T + DRE+ A + V
Sbjct: 1121 KVSAVDKDFGPNGEVRYSFEMVQP-DFELHAISGEITNTHQFDRESLMRRRGTAVFSFTV 1179
Query: 307 RAQNSHGEDYAAPLE----LHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAED 362
A + + PL+ +HV + D NDN P +I E + T+V R+SA D
Sbjct: 1180 IATD---QGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASD 1236
Query: 363 ADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAMD 421
D N + Y ++ G E R F +D TSG VTL G L A L++ A+D
Sbjct: 1237 VDE--GNNGLIHYSIIK-----GNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVD 1289
Query: 422 LAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEP 481
+STC + + + D ND+ P F S + + + E++ G LV+ +TA D+D
Sbjct: 1290 SGTIP--LNSTCTLNIDILDENDNTPSFPKSTLF-VDVLENMRIGELVSSVTATDSDSGD 1346
Query: 482 AFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGP 541
L ++I + GTF + P++G + L K L +E +++ + + +
Sbjct: 1347 NADLY-YSITGTNNHGTFSI--SPNTGSI--FLAKKLDFETQSLYKLNITAKDQGR---- 1397
Query: 542 GPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQPSDP---ISRTLR 597
P +T +V + V PP S+ + P G+ ++++ DP I+ L
Sbjct: 1398 -PPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLS 1456
Query: 598 FSLVNDSE--GWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEP 644
++++ I++ G ++T + + + + + V+A D P
Sbjct: 1457 YTIIQQMPRGNHFTIDEVKGTIYTNAEID-REFANLFELTVKANDQAVP 1504
Score = 114 bits (286), Expect = 3e-25
Identities = 155/617 (25%), Positives = 249/617 (40%), Gaps = 66/617 (10%)
Query: 46 LPREGAEGQIVLSGDSGKATEG--------------PFAMDPDSGFLLVTRALDREEQAE 91
+P + G VL + A EG PF MDP++G + V LD E + +
Sbjct: 259 VPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQ 318
Query: 92 YQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP-----HFSQAIYRARLSRGTRPGIPFL 146
Y L V + L G L+ + D ND P +F A + + G
Sbjct: 319 YSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVA 378
Query: 147 FLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERT 206
L +D D P AN ++ IL + P L + K +++LD +
Sbjct: 379 LLTVTDADSP-AANGNISVQILGGNEQRHFEVQSSKVPNLSLI----KVASALDRERIPS 433
Query: 207 YQLLVQVKDMGDQASGH--QATATVEVSIIESTWVSLEPIHLAE-----NLKVLYP--HH 257
Y L V V D G QA ++V +I ++ P ++ NL P +
Sbjct: 434 YNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSY 493
Query: 258 MAQVHWSGGD------VHYHLES-HPPGPFEVNAEGNLYVTRE---LDREAQAEYLLQVR 307
++ + + GD + Y + S + G F ++ L T LDRE ++ +L +
Sbjct: 494 VSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNIS 553
Query: 308 AQNSHGEDYAAPLELHVLVMDENDNVPI-CPPRDPTVSIPELSPPGTEVTRLSAEDADAP 366
A++ + +L V ++D ND P+ P VS+ E +P GTE+ L A D D
Sbjct: 554 ARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDL- 612
Query: 367 GSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLVLAMDLAGA 425
N V + L E + R+F++DP SG + T+ L LLVLA DL
Sbjct: 613 -GDNGTVRFSLQEAE----TDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSP 667
Query: 426 EGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRL 485
SS + V++ DIND++P F Q + E+ G+ + ++A D DL
Sbjct: 668 PQ--SSMARINVSLLDINDNSPVFYPVQYF-AHIKENEPGGSYITTVSATDPDL-GTNGT 723
Query: 486 MDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGP 545
+ ++I GD SG + R+ L E ++++ +V L P
Sbjct: 724 VKYSISAGDRS---RFQVNAQSGVISTRMA--LDREEKTAYQLQIVATDGGNLQSPNQ-- 776
Query: 546 GATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPS--DPISRTLRFSLVND 603
A T+TVL + PP Q +Y V + G + ++ S D S D
Sbjct: 777 -AIVTITVL-DTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGD 834
Query: 604 SEGWLCIEKFSGEVHTA 620
+G I + +G++ TA
Sbjct: 835 QKGMFAINQVTGQLTTA 851
Score = 106 bits (264), Expect = 1e-22
Identities = 127/501 (25%), Positives = 216/501 (43%), Gaps = 49/501 (9%)
Query: 109 PQP------VLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSD 162
PQP V V++KD ND P F + Y+A +S L + ASD DE N
Sbjct: 1187 PQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGN--NGL 1244
Query: 163 LRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASG 222
+ + I+ + F ++ G + L K LD+ Y L++Q D G
Sbjct: 1245 IHYSIIKGNEER----QFAIDSTSGQVTLIGK----LDYEATPAYSLVIQAVDSGTIPLN 1296
Query: 223 HQATATVEVSIIESTWVSLEP----IHLAENLKV--LYPHHMAQVHWSG--GDVHYHLE- 273
T +++ S + + EN+++ L A SG D++Y +
Sbjct: 1297 STCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITG 1356
Query: 274 SHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
++ G F ++ G++++ ++LD E Q+ Y L + A++ ++ + + + V D NDN
Sbjct: 1357 TNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDN 1416
Query: 333 VPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQ 392
P PP D SI E P GT V ++A D DA N + Y ++ P G F
Sbjct: 1417 PPSFPPGDIFKSIVENIPIGTSVISVTAHDPDA--DINGQLSYTIIQQMP----RGNHFT 1470
Query: 393 VDPTSGSVTLGVLPLRAGQNIL-LLVLAMDLA-GAEGGFSSTCEVEVAVTDINDHAPEFI 450
+D G++ R N+ L V A D A E + V + VTD+ND+ P FI
Sbjct: 1471 IDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFI 1530
Query: 451 TSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHV 510
+ ++ G+++ + A D D E A +++ I GDT+ TF +D SG +
Sbjct: 1531 SQ--NALAADPSAVIGSVLTTIMAADPD-EGANGEIEYEIINGDTD-TFIVD--RYSGDL 1584
Query: 511 RLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMPPPKLDQESYE 570
R ++ PS + ++ S L GP + T ++ + + P Q Y
Sbjct: 1585 R------VASALVPSQLIYNLIVSATDL---GPERRKSTTELTIILQGLDGPVFTQPKYI 1635
Query: 571 ASVPISAPAGSFLLTIQPSDP 591
+ P G+ +++I+ + P
Sbjct: 1636 TILKEGEPIGTNVISIEAASP 1656
Score = 104 bits (259), Expect = 4e-22
Identities = 126/539 (23%), Positives = 223/539 (41%), Gaps = 47/539 (8%)
Query: 67 GPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHF 126
G F +D D+G++ V +L + + + VT + + L V + V +EN P F
Sbjct: 3030 GKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEF 3089
Query: 127 SQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRL 186
SQ+ A + G + A DRD N +++ I S +F +
Sbjct: 3090 SQSHMSATIPESHSIGSIVRTVSARDRD--AAMNGLIKYSISSGN----EEGIFAINSST 3143
Query: 187 GALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHL 246
G L L+ +LD+ L + +++ + D G A + TV V + P+ L
Sbjct: 3144 GILTLAK----ALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDN----SPVFL 3195
Query: 247 AENL--KVLY--PHHMAQVHWSGGD--------VHYHLESHPPGPFEVNAEGNLYVTRE- 293
+++ VL P +H + D + Y ++S F ++ + T+
Sbjct: 3196 SDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGF 3255
Query: 294 LDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGT 353
LD E + Y L V+A N E+ + +++ + N+ VP + I E +P GT
Sbjct: 3256 LDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGT 3315
Query: 354 EVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTL-GVLPLRAGQN 412
V + A D D + V Y + + G FQ++ +G + + G+L +
Sbjct: 3316 IVGEVFASDRDL--GTDGEVHYLIFGNSRKKG-----FQINKKTGQIYVSGILDREKEER 3368
Query: 413 ILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAML 472
+ L VLA + G V V V D ND P T I + + E V GT V +
Sbjct: 3369 VSLKVLAKNFGSIRGADIDEVTVNVTVLDAND--PPIFTLNIYSVQISEGVPIGTHVTFV 3426
Query: 473 TAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVV 532
+A D+D P++ + I G+ G F ++ P +G ++ + L E P + +
Sbjct: 3427 SAFDSDSIPSWSRFSYFIGSGNENGAFSIN--PQTG--QITVTAELDRETLPIYNL---- 3478
Query: 533 QSVAKLVGPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDP 591
SV + P +A++ V +E + + S E V + G+ ++T+Q +DP
Sbjct: 3479 -SVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVS-EGEVMENKRPGTLVMTLQSTDP 3535
Score = 102 bits (254), Expect = 1e-21
Identities = 128/489 (26%), Positives = 209/489 (42%), Gaps = 61/489 (12%)
Query: 18 PKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGF 77
P+ + +S +PE++ + T R+ A ++ S EG FA++ +G
Sbjct: 3087 PEFSQSHMSATIPESHSIG-SIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGI 3145
Query: 78 LLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSR 137
L + +ALD E ++++ ++ G V V+V D ND P F Y +
Sbjct: 3146 LTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLE 3205
Query: 138 GTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGST 197
G + L A+D D A +++ D+F ++P G +
Sbjct: 3206 NAPSGTTVIHLNATDADSGTNA-------VIAYTVQSSDSDLFVIDPNTGVITT----QG 3254
Query: 198 SLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHH 257
LD +++Y L V+ ++ D+ AT +++ ++ + LY
Sbjct: 3255 FLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNE--------YVPRFVSKLYYFE 3306
Query: 258 MAQVHWSG----------------GDVHYHL--ESHPPGPFEVNAE-GNLYVTRELDREA 298
+++ G G+VHY + S G F++N + G +YV+ LDRE
Sbjct: 3307 ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG-FQINKKTGQIYVSGILDREK 3365
Query: 299 QAEYLLQVRAQNSHGEDYAAPLE---LHVLVMDENDNVPICPPRDPTVSIPELSPPGTEV 355
+ L+V A+N G A ++ ++V V+D ND PI +V I E P GT V
Sbjct: 3366 EERVSLKVLAKN-FGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHV 3423
Query: 356 TRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNIL- 414
T +SA D+D+ S + S G E AF ++P +G +T+ R I
Sbjct: 3424 TFVSAFDSDSIPS------WSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYN 3477
Query: 415 LLVLAMDLAGAEGGFSSTCEVEVAVT--DINDHAPEFITSQIGPISLPEDVEPGTLVAML 472
L VLA+D G S+T + VT DIND+ P S+ G + E+ PGTLV L
Sbjct: 3478 LSVLAVD----SGTPSATGSASLLVTLEDINDNGPMLTVSE-GEVM--ENKRPGTLVMTL 3530
Query: 473 TAIDADLEP 481
+ D DL P
Sbjct: 3531 QSTDPDLPP 3539
Score = 97.1 bits (240), Expect = 6e-20
Identities = 141/617 (22%), Positives = 252/617 (40%), Gaps = 59/617 (9%)
Query: 112 VLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQA 171
V +++ D ND P F ++ Y +++ + G + + A D + G NS++ + I +
Sbjct: 2969 VTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGL-NSEVEYFISNDN 3027
Query: 172 PAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEV 231
F+L+ G ++++ +SL L + + + V KD G+ QAT V +
Sbjct: 3028 HL----GKFKLDNDTGWISVA----SSLISDLNQNFFITVTAKDKGNPPLSSQAT--VHI 3077
Query: 232 SIIESTWVSLEPIHLAENLKVLYPHHMAQVHWS----------GGDVHYHLES-HPPGPF 280
++ E + + E + + H + + + G + Y + S + G F
Sbjct: 3078 TVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIF 3137
Query: 281 EVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPR 339
+N+ G L + + LD E ++ + + A + + V V+D NDN P+
Sbjct: 3138 AINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSD 3197
Query: 340 DPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGS 399
D ++ E +P GT V L+A DAD+ N+ + Y + S + + F +DP +G
Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADS--GTNAVIAYTVQSSDSD------LFVIDPNTGV 3249
Query: 400 VTL-GVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPIS 458
+T G L Q+ L V A ++ E +T +++ T N++ P F+ S++
Sbjct: 3250 ITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGT--NEYVPRFV-SKLYYFE 3306
Query: 459 LPEDVEPGTLVAMLTAIDADL--EPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCK 516
+ E GT+V + A D DL + + F R G +G + +
Sbjct: 3307 ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKK-----GFQINKKTGQIYVSGIL 3361
Query: 517 NLSYEAAPSHEVVVVVQSVAKLVGPGPGPGAT-ATVTVLVERVMPPPKLDQESYEASVPI 575
+ E S +V+ AK G G TV V V PP Y +
Sbjct: 3362 DREKEERVSLKVL------AKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISE 3415
Query: 576 SAPAGSFLLTIQP--SDPISRTLRFSLV---NDSEGWLCIEKFSGEVHTAQSLQGAQPGD 630
P G+ + + SD I RFS + G I +G++ L +
Sbjct: 3416 GVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELD-RETLP 3474
Query: 631 TYTVLVEAQDTDEPRLSASAPLVIHFLKAPP-APALTLAPVPSQYLCTPRQDHGLIVSGP 689
Y + V A D+ P + SA L++ P LT V + ++ L+++
Sbjct: 3475 IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLT---VSEGEVMENKRPGTLVMTLQ 3531
Query: 690 SKDPDLASGHGPYSFTL 706
S DPDL GP+++ L
Sbjct: 3532 STDPDLPPNQGPFTYYL 3548
Score = 95.9 bits (237), Expect = 1e-19
Identities = 153/644 (23%), Positives = 256/644 (39%), Gaps = 66/644 (10%)
Query: 50 GAEGQI---VLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVL 106
GA G+I + G++G A F + PD G L + LDRE Q Y L V + L
Sbjct: 1026 GANGEIAYTIAEGNTGDA----FGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAVEPL 1080
Query: 107 WGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFH 166
V V ++D ND P F+ Y R G + A D+D N ++R+
Sbjct: 1081 SATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFG--PNGEVRY- 1137
Query: 167 ILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER----------TYQLLVQVKDM 216
S +M Q + L A++ G + H +R + V D
Sbjct: 1138 ---------SFEMVQPDFELHAIS----GEITNTHQFDRESLMRRRGTAVFSFTVIATDQ 1184
Query: 217 G-DQASGHQATATVEVSIIEST-------WVSLEPIHLAENLKVLYPHHMAQV-HWSGGD 267
G Q QAT V + I + A NL + + V + G
Sbjct: 1185 GIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGL 1244
Query: 268 VHYHL-ESHPPGPFEVNA-EGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVL 325
+HY + + + F +++ G + + +LD EA Y L ++A +S + L++
Sbjct: 1245 IHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNID 1304
Query: 326 VMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDG 385
++DENDN P P V + E G V+ ++A D+D+ N+ + Y +
Sbjct: 1305 ILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDS--GDNADLYYSITGTNNHG- 1361
Query: 386 VEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDH 445
F + P +GS+ L Q++ L + G SST V + V D ND+
Sbjct: 1362 ----TFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR-SSTMSVVIHVRDFNDN 1416
Query: 446 APEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEP 505
P F I S+ E++ GT V +TA D D + +L I++ F +D
Sbjct: 1417 PPSFPPGDIFK-SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTID--- 1472
Query: 506 DSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMPPPKLD 565
V+ + N + ++ + V++ + V A VT+LV + +
Sbjct: 1473 ---EVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMF 1529
Query: 566 QESYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSEGWLCIEKFSGEVHTAQS 622
+ SA GS L TI +DP + + + ++N ++++SG++ A +
Sbjct: 1530 ISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASA 1589
Query: 623 LQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALT 666
L +Q Y ++V A D R ++ L I L+ P T
Sbjct: 1590 LVPSQL--IYNLIVSATDLGPERRKSTTELTI-ILQGLDGPVFT 1630
Score = 95.5 bits (236), Expect = 2e-19
Identities = 151/634 (23%), Positives = 254/634 (40%), Gaps = 60/634 (9%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHV--KDENDQVPHF 126
F + +G + LDRE+ A L ++ Q V + +D ND P F
Sbjct: 1681 FTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVF 1740
Query: 127 SQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRL 186
+ + G + L A D DE AN+ + + I+S A D F+++P
Sbjct: 1741 PTDMLDLTVEENIGDGSKIMQLTAMDADEG--ANALVTYTIISGAD-----DSFRIDPES 1793
Query: 187 GALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHL 246
G L + + LD Y LLV+ D G Q+S + TV + + T P++
Sbjct: 1794 GDLIATRR----LDRERRSKYSLLVRADD-GLQSSDMRINITVS-DVNDHTPKFSRPVYS 1847
Query: 247 AENLKVLYPHHMAQVHWS-------GGDVHYHL-ESHPPGPFEVNA-EGNLYVTRELDRE 297
+ + P + + G++ Y + E G F +N G +TR LD E
Sbjct: 1848 FDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYE 1907
Query: 298 AQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTR 357
Q Y+L VRA++ G+ + ++ ++D NDN PI + S+ E P G+ V
Sbjct: 1908 VQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLV 1965
Query: 358 LSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLV 417
+ DAD NS + Y + S G F VD L L + L+V
Sbjct: 1966 FNVTDAD--DGINSQLTYSIAS-----GDSLGQFTVDKNGVLKVLKALDRESQSFYNLVV 2018
Query: 418 LAMDLAGAEGG-FSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAID 476
DL F+ST +V + + D+ND+ P F++ ++ +PE+ T+V A D
Sbjct: 2019 QVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL--TYIPENTPIDTVVFKAQATD 2076
Query: 477 ADLEPAFRLMDFAIERGDTEGTFG-LDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSV 535
D P + + + + G +D E +RL L E ++ + VV
Sbjct: 2077 PDSGPNSYIEYTLLNPLGNKFSIGTIDGE-------VRLTGELDREEVSNYTLTVVATDK 2129
Query: 536 AKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQPSDPISR 594
+ P ++ V V+V + P Q Y+ + + G+ ++ + +D
Sbjct: 2130 GQ-----PSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEG 2184
Query: 595 T---LRFSLVN-DSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDT-DEPRLSAS 649
T +R+ +VN ++ I+ +G + A+ L + TY + V+A D PR S
Sbjct: 2185 TNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLD-REKTPTYHLTVQATDRGSTPRTDTS 2243
Query: 650 APLVIHFLKAPPAPALTLAP----VPSQYLCTPR 679
++ P L+P VP PR
Sbjct: 2244 TVSIVLLDINDFVPVFELSPYSVNVPENLGTLPR 2277
Score = 95.1 bits (235), Expect = 2e-19
Identities = 121/542 (22%), Positives = 233/542 (42%), Gaps = 53/542 (9%)
Query: 68 PFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFS 127
PF ++P +G ++++R L+RE+ Y+++V+ V V + V D ND P FS
Sbjct: 2817 PFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTV---STDVTIFVTDINDNAPRFS 2873
Query: 128 QAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLG 187
+ Y T G + A+D DE +N + + I SQ+ + F++ G
Sbjct: 2874 RTSYYLDCPELTEIGSKVTQVFATDPDE--GSNGQVFYFIKSQS------EYFRINATTG 2925
Query: 188 AL----ALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEV--------SIIE 235
+ L + T + + +V D G + + T T+ + ++
Sbjct: 2926 EIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLK 2985
Query: 236 STWVSLEPIHLAENLKVLYPHHMAQVHWS-GGDVHYHLES-HPPGPFEV-NAEGNLYVTR 292
S + + ++ K++ + + +V Y + + + G F++ N G + V
Sbjct: 2986 SKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVAS 3045
Query: 293 ELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPG 352
L + + + V A++ ++ +H+ V +EN + P + +IPE G
Sbjct: 3046 SLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIG 3105
Query: 353 TEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQN 412
+ V +SA D DA + N + Y + S G E F ++ ++G +TL +A
Sbjct: 3106 SIVRTVSARDRDA--AMNGLIKYSISS-----GNEEGIFAINSSTGILTLA----KALDY 3154
Query: 413 ILLLVLAMDLAGAEGGF---SSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLV 469
L M ++ +GG+ + C V V V D+ND++P F++ P L E+ GT V
Sbjct: 3155 ELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL-ENAPSGTTV 3213
Query: 470 AMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVV 529
L A DAD ++ + ++ D++ F +D P++G + + L +E S+ +
Sbjct: 3214 IHLNATDAD-SGTNAVIAYTVQSSDSD-LFVID--PNTGVITTQ--GFLDFETKQSYHLT 3267
Query: 530 VVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQP 588
V +V P + ATV + ++ P+ + Y + +AP G+ + +
Sbjct: 3268 VKAFNV-----PDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFA 3322
Query: 589 SD 590
SD
Sbjct: 3323 SD 3324
Score = 92.8 bits (229), Expect = 1e-18
Identities = 127/547 (23%), Positives = 227/547 (41%), Gaps = 51/547 (9%)
Query: 61 SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEN 120
+G G F++ P++G + + + LD E Q+ Y+L +T + Q V++HV+D N
Sbjct: 1355 TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFN 1414
Query: 121 DQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMF 180
D P F + G + + A D D N L + I+ Q P + F
Sbjct: 1415 DNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPD--ADINGQLSYTIIQQ---MPRGNHF 1469
Query: 181 QLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVS 240
++ G + + +D ++L V+ D + A V+I+ +
Sbjct: 1470 TIDEVKGTIYT----NAEIDREFANLFELTVKANDQAVPIETRR-YALKNVTILVTDLND 1524
Query: 241 LEPIHLAENLKVLYPHHMA-----------QVHWSGGDVHYHLESHPPGPFEVNA-EGNL 288
P+ +++N P + + G++ Y + + F V+ G+L
Sbjct: 1525 NVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDL 1584
Query: 289 YVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPEL 348
V L +Q Y L V A + E + EL +++ D P+ T+ + E
Sbjct: 1585 RVASAL-VPSQLIYNLIVSATDLGPERRKSTTEL-TIILQGLDGPVFTQPKYITI-LKEG 1641
Query: 349 SPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPL 407
P GT V + +A +P + V Y ++S E+ GR F + +G + T +L
Sbjct: 1642 EPIGTNVISI---EAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDR 1698
Query: 408 RAGQNILLL-VLAMDLAGAEGGFSST--CEVEVAVTDINDHAPEFITSQIGPISLPEDVE 464
G + L+ V A++ + A F T EVE+ + DIND+ P F T + +++ E++
Sbjct: 1699 EQGACLYLVDVYAIEKSTA---FPRTQRAEVEITLQDINDNPPVFPTDML-DLTVEENIG 1754
Query: 465 PGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAP 524
G+ + LTA+DAD E A L+ + I G + +F +D P+SG L + L E
Sbjct: 1755 DGSKIMQLTAMDAD-EGANALVTYTIISG-ADDSFRID--PESGD--LIATRRLDRERRS 1808
Query: 525 SHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFL 583
+ ++V + + + + V V PK + Y +P GS +
Sbjct: 1809 KYSLLVRADDGLQ--------SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLV 1860
Query: 584 LTIQPSD 590
I +D
Sbjct: 1861 AAILATD 1867
Score = 92.0 bits (227), Expect = 2e-18
Identities = 139/618 (22%), Positives = 257/618 (41%), Gaps = 80/618 (12%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTL-EMQDGHVLWGPQPVLVHVKDENDQVPHFS 127
F ++P +G ++ + LDRE + Y L V + L VLV V D ND P F
Sbjct: 2408 FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQ 2467
Query: 128 QAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLG 187
Y + T PG + +D D NS+L + + + + + F ++P G
Sbjct: 2468 HHPYVTHIPSPTLPGSFVFAVTVTDADIG--PNSELHYSLSGR-----NSEKFHIDPLRG 2520
Query: 188 ALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATV---------EVSIIESTW 238
A+ + L+ A E T+ V VKD G T TV +V E T+
Sbjct: 2521 AIM----AAGPLNGASEVTFS--VHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTF 2574
Query: 239 VSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPG-PFEVNA-EGNLYVTRELDR 296
+ E ++ + + + G + Y++ S G F+++ G + +++ LD
Sbjct: 2575 MFPENQPVSSLVTTITGSSLR-----GEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDF 2629
Query: 297 EAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVS--IPELSPPGTE 354
E +Y++ + A++ +++ +L + V+D NDN PI DP +S + LSP +
Sbjct: 2630 EKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFK-EDPFISEILENLSP--RK 2686
Query: 355 VTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPL-RAGQNI 413
+ +SA D D+ PN + Y++++ E+ +F ++ +G + V PL R +
Sbjct: 2687 ILTVSAMDKDS--GPNGQLDYEIVNGNMEN-----SFSINHATGEIR-SVRPLDREKVSH 2738
Query: 414 LLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLT 473
+L + G+ S++ +V + + D ND+AP F SQI +PE+ G V +T
Sbjct: 2739 YVLTIKSSDKGSPSQ-STSVKVMINILDENDNAPRF--SQIFSAHVPENSPLGYTVTRVT 2795
Query: 474 AIDADLE----PAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVV 529
D D+ + +MD ++ P +G + + + L+ E + +
Sbjct: 2796 TSDEDIGINAISRYSIMDASLP---------FTINPSTGDI--VISRPLNREDTDRYRIR 2844
Query: 530 VVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQP 588
V G + VT+ V + P+ + SY P GS + +
Sbjct: 2845 VSAHD--------SGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFA 2896
Query: 589 SDPI--SRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPG-------DTYTVLVEAQ 639
+DP S F + + I +GE+ Q L+ + ++ +V +
Sbjct: 2897 TDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSS 2956
Query: 640 DTDEPRLSASAPLVIHFL 657
D +P L + + I+ +
Sbjct: 2957 DRGKPSLISETTVTINIV 2974
Score = 90.9 bits (224), Expect = 4e-18
Identities = 149/652 (22%), Positives = 241/652 (36%), Gaps = 71/652 (10%)
Query: 35 GNFPLYLTKLPLPREGAEGQI---VLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAE 91
G LT A G I +L G+ + E + P+ + V ALDRE
Sbjct: 374 GTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPS 433
Query: 92 YQLQVTLEMQDG-------HVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIP 144
Y L V++ G +++ V D ND P FSQ +YR LS PG
Sbjct: 434 YNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSY 493
Query: 145 FLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLD---- 200
+ A+D D N++LR+ I+S F + G + G +
Sbjct: 494 VSGISATDGDSG--LNANLRYSIVSGNGL----GWFHISEHSGLVTTGSSGGLDRELASQ 547
Query: 201 ------------HALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAE 248
H QL+V + D+ D+ +VS++E+ E + L
Sbjct: 548 IVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRA 607
Query: 249 NLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRA 308
L + V +S + S P G L LDRE QA Y L V A
Sbjct: 608 TDGDLGDN--GTVRFSLQEAETDRRSFRLDP----VSGRLSTISSLDREEQAFYSLLVLA 661
Query: 309 QNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGS 368
+ ++ ++V ++D NDN P+ P I E P G+ +T +SA D D
Sbjct: 662 TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDL--G 719
Query: 369 PNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLVLAMDLAGAEG 427
N V Y + + + FQV+ SG + T L L ++A D G
Sbjct: 720 TNGTVKYSISAGDRS------RFQVNAQSGVISTRMALDREEKTAYQLQIVATD--GGNL 771
Query: 428 GFSSTCEVEVAVTDINDHAPEFITSQIG-PISLPEDVEPGTLVAMLTAIDADLEPAFRLM 486
+ V + V D D+ P F SQ+ + E+V G V ++A DL +
Sbjct: 772 QSPNQAIVTITVLDTQDNPPVF--SQVAYSFVVFENVALGYHVGSVSASTMDLNSN---I 826
Query: 487 DFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPG 546
+ I GD +G F ++ +L + E +++ VV G G
Sbjct: 827 SYLITTGDQKGMFAINQVTG----QLTTANVIDREEQSFYQLKVVASG-------GTVTG 875
Query: 547 ATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLL---TIQPSDPISRTLRFSLVND 603
T + + P Q +V + AG + + P + ++ + +SL +
Sbjct: 876 DTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQN 935
Query: 604 SEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIH 655
+ I + +G + L +Y + + A D P+LS+S L ++
Sbjct: 936 PKNLFAINEKNGTISLLGPLD--VHAGSYQIEILASDMGVPQLSSSVILTVY 985
Score = 87.4 bits (215), Expect = 5e-17
Identities = 146/620 (23%), Positives = 247/620 (39%), Gaps = 59/620 (9%)
Query: 50 GAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGP 109
G GQ+ +G E F+++ +G + R LDRE+ + Y L + +
Sbjct: 2698 GPNGQLDYEIVNGNM-ENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTS 2756
Query: 110 QPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILS 169
V++++ DEND P FSQ I+ A + + G + SD D+ + +S
Sbjct: 2757 VKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSD--------EDIGINAIS 2807
Query: 170 QAPAQPSPDMFQLEPRLGALALS-PKGSTSLDHALERTYQLLVQVKDMGDQASGHQATAT 228
+ + F + P G + +S P D Y++ V D G S
Sbjct: 2808 RYSIMDASLPFTINPSTGDIVISRPLNREDTDR-----YRIRVSAHDSGWTVSTDVTIFV 2862
Query: 229 VEVS----IIESTWVSLEPIHLAE-NLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVN 283
+++ T L+ L E KV S G V Y ++S F +N
Sbjct: 2863 TDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE-YFRIN 2921
Query: 284 AEGNLYVTRELDREAQAEYLLQVRAQNSH-----GEDYAAP-----LELHVLVMDENDNV 333
A +++ + V N H D P + + ++D NDN
Sbjct: 2922 ATTGEIFNKQILKYQNVTGFSNVNI-NRHSFIVTSSDRGKPSLISETTVTINIVDSNDNA 2980
Query: 334 PICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQV 393
P + + GT++ R++A D D NS V Y + D G+ F++
Sbjct: 2981 PQFLKSKYFTPVTKNVKVGTKLIRVTAID-DKDFGLNSEVEYFI----SNDNHLGK-FKL 3034
Query: 394 DPTSGSVTL-GVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITS 452
D +G +++ L QN + V A D SS V + VT+ N H PEF S
Sbjct: 3035 DNDTGWISVASSLISDLNQNFFITVTAKDKGNPP--LSSQATVHITVTEENYHTPEFSQS 3092
Query: 453 QIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRL 512
+ ++PE G++V ++A D D L+ ++I G+ EG F + +S L
Sbjct: 3093 HMS-ATIPESHSIGSIVRTVSARDRD-AAMNGLIKYSISSGNEEGIFAI----NSSTGIL 3146
Query: 513 RLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEA 571
L K L YE HE+ +++ + G +VTV V V P + Y
Sbjct: 3147 TLAKALDYELCQKHEM-----TISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFP 3201
Query: 572 SVPISAPAGSFLLTIQPSDPISRT---LRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQP 628
+V +AP+G+ ++ + +D S T + +++ + I+ +G V T Q +
Sbjct: 3202 TVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTG-VITTQGFLDFET 3260
Query: 629 GDTYTVLVEAQDT-DEPRLS 647
+Y + V+A + DE R S
Sbjct: 3261 KQSYHLTVKAFNVPDEERCS 3280
Score = 83.6 bits (205), Expect = 7e-16
Identities = 146/648 (22%), Positives = 241/648 (37%), Gaps = 73/648 (11%)
Query: 49 EGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWG 108
EG GQ+ +G T F +D +G + V + LDRE+ Y L V +
Sbjct: 2183 EGTNGQVRYGIVNGN-TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTD 2241
Query: 109 PQPVLVHVKDENDQVPHFSQAIYRARL--SRGTRPGIPFLFLEASDRDEPGTANSDLRFH 166
V + + D ND VP F + Y + + GT +P L+ RD+ +NS L +
Sbjct: 2242 TSTVSIVLLDINDFVPVFELSPYSVNVPENLGT---LPRTILQVVARDDDRGSNSKLSYV 2298
Query: 167 ILSQAPAQPSPDMFQLEPRLGALALSPKG----STSLDHALERTYQLLVQVKDMGDQASG 222
+ A LS G + SLD + + L++ D G A
Sbjct: 2299 LFGGNED-------------NAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPA-- 2343
Query: 223 HQATATVEVSIIESTWVSLEPIHLAENLKVLYPH------HMAQVHWSGGDVHYHLESHP 276
T T +++I P ++ P + V+ S D +
Sbjct: 2344 --LTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRI 2401
Query: 277 PG---PFEVN-AEGNLYVTRELDREAQAEYLLQVRAQNSHG-EDYAAPLELHVLVMDEND 331
G F +N + G + + LDRE + Y L V ++ E ++ + V V D ND
Sbjct: 2402 IGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVND 2461
Query: 332 NVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAF 391
N P IP + PG+ V ++ DAD PNS + Y L G F
Sbjct: 2462 NPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADI--GPNSELHYSL------SGRNSEKF 2513
Query: 392 QVDPTSGSVTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFIT 451
+DP G++ + PL + V D G F T V V +N +
Sbjct: 2514 HIDPLRGAI-MAAGPLNGASEVTFSVHVKD----GGSFPKTDSTTVTVRFVNKADFPKVR 2568
Query: 452 SQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVR 511
++ PE+ +LV +T EP M + I G+ TF +D +
Sbjct: 2569 AKEQTFMFPENQPVSSLVTTITGSSLRGEP----MSYYIASGNLGNTFQIDQLTG----Q 2620
Query: 512 LRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMPPPKLDQESYEA 571
+ + + L +E + V + + G P + + + V V + +E
Sbjct: 2621 VSISQPLDFEKIQKYVVWIEARD-----GGFPPFSSYEKLDITVLDVNDNAPIFKEDPFI 2675
Query: 572 SVPISAPAGSFLLTIQPSDPIS---RTLRFSLVN-DSEGWLCIEKFSGEVHTAQSLQGAQ 627
S + + +LT+ D S L + +VN + E I +GE+ + + L +
Sbjct: 2676 SEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLD-RE 2734
Query: 628 PGDTYTVLVEAQDTDEPRLSASAPLVIHFL----KAPPAPALTLAPVP 671
Y + +++ D P S S ++I+ L AP + A VP
Sbjct: 2735 KVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVP 2782
Score = 75.1 bits (183), Expect = 2e-13
Identities = 107/430 (24%), Positives = 168/430 (39%), Gaps = 38/430 (8%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQ 128
F +DP++G + LD E + Y L V V + +K N+ VP F
Sbjct: 3241 FVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVS 3300
Query: 129 AIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGA 188
+Y +S G + ASDRD +D H L ++ FQ+ + G
Sbjct: 3301 KLYYFEISEAAPKGTIVGEVFASDRD----LGTDGEVHYLIFGNSRKKG--FQINKKTGQ 3354
Query: 189 LALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIEST-----WVSLEP 243
+ +S LD E L V K+ G TV V+++++ +++
Sbjct: 3355 IYVSG----ILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYS 3410
Query: 244 IHLAENLKVLYPHHMAQVHWSGGD-------VHYHLES-HPPGPFEVNAE-GNLYVTREL 294
+ ++E + + H+ V D Y + S + G F +N + G + VT EL
Sbjct: 3411 VQISEGVPI--GTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAEL 3468
Query: 295 DREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTE 354
DRE Y L V A +S L V + D NDN P+ + V E PGT
Sbjct: 3469 DRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKRPGTL 3526
Query: 355 VTRLSAEDADAPGSPN-SHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNI 413
V L + D D P PN Y LLS P F + T + +
Sbjct: 3527 VMTLQSTDPDLP--PNQGPFTYYLLSTGPATSY----FSLSTAGVLSTTREIDREQIADF 3580
Query: 414 LLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLT 473
L V+ D + SST V + V D ND+ + T +I ++ ++ PG ++ +
Sbjct: 3581 YLSVVTKDSGVPQ--MSSTGTVHITVIDQNDNPSQSRTVEIF-VNYYGNLFPGGILGSVK 3637
Query: 474 AIDADLEPAF 483
D D+ +F
Sbjct: 3638 PQDPDVLDSF 3647
Score = 70.1 bits (170), Expect = 8e-12
Identities = 81/272 (29%), Positives = 119/272 (43%), Gaps = 38/272 (13%)
Query: 273 ESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDEND 331
ESH F +N+ G LY T +DRE+ ++ + +S P E+ VLV D ND
Sbjct: 76 ESH--ALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP---TYPTEVRVLVRDLND 130
Query: 332 NVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAF 391
N P+ P V+ E S G +V +A D+D + H Y+++ G E F
Sbjct: 131 NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIR-----GNEAGRF 185
Query: 392 QVDPT---SGS------VTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDI 442
++D T SG V+ G L LLV D E +V V V DI
Sbjct: 186 RLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVED--KGEPKRRGYLQVNVTVQDI 243
Query: 443 NDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD----LEPAFRLMDFAIERGDTEGT 498
ND+ P F +S +PED G+ V + A DAD + +RL D EGT
Sbjct: 244 NDNPPVFGSSHY-QAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD--------EGT 294
Query: 499 FGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVV 530
+P++G + +R + L +EA + + V
Sbjct: 295 -PFQMDPETGLITVR--EPLDFEARRQYSLTV 323
Score = 60.1 bits (144), Expect = 8e-09
Identities = 81/311 (26%), Positives = 132/311 (42%), Gaps = 34/311 (10%)
Query: 50 GAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLW 107
G +G++ ++ G+S K F ++ +G + V+ LDRE++ L+V L G +
Sbjct: 3328 GTDGEVHYLIFGNSRKKG---FQINKKTGQIYVSGILDREKEERVSLKV-LAKNFGSIRG 3383
Query: 108 GP---QPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLR 164
V V V D ND P F+ IY ++S G G F+ A D D + S R
Sbjct: 3384 ADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAFDSD---SIPSWSR 3439
Query: 165 FHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQ 224
F + + F + P+ G + ++ + LD Y L V D G ++
Sbjct: 3440 FSYFIGSGNENGA--FSINPQTGQITVTAE----LDRETLPIYNLSVLAVDSGTPSATGS 3493
Query: 225 ATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSG--------GDVHYHLESHP 276
A+ V + I L + E ++ P + S G Y+L S
Sbjct: 3494 ASLLVTLEDINDNGPMLT-VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTG 3552
Query: 277 PGP--FEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 334
P F ++ G L TRE+DRE A++ L V ++S ++ +H+ V+D+NDN
Sbjct: 3553 PATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDN-- 3610
Query: 335 ICPPRDPTVSI 345
P + TV I
Sbjct: 3611 --PSQSRTVEI 3619
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 151 bits (382), Expect = 2e-36
Identities = 161/558 (28%), Positives = 248/558 (44%), Gaps = 53/558 (9%)
Query: 284 AEGNLYVTRELDREAQAEYLLQVRA-QNSHGEDYAAPLELHVLVMDENDNVPICPPRDPT 342
A GN++VT+ LDRE +A+Y+L +A + P E + V D NDN PI P
Sbjct: 97 ATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYH 156
Query: 343 VSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPEPEDGVEGRAFQVDPTSGSVT 401
++PE+S GT V +++A DAD P NS +VY +L P F VDP +G V
Sbjct: 157 ATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLP-------FFSVDPQTGVVR 209
Query: 402 LGV--LPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISL 459
+ + + L+++ A D+ G GG S + V V ++D+ND+ P+F S + S+
Sbjct: 210 TAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQS-LYQFSV 268
Query: 460 PEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLS 519
E PGTLV L A D DL LM ++I G+ F + + L + K L
Sbjct: 269 VETAGPGTLVGRLRAQDPDLGDN-ALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLD 327
Query: 520 YEAAPSHEVVVVVQSVAKLVGPG---PGP-GATATVTVLVERVMPPPKLDQESYEASVPI 575
+E+ S+ V++ L+ P GP A+V V V+ PP Q +Y +VP
Sbjct: 328 FESQRSYS--FRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPE 385
Query: 576 SAPAGSFLLTIQPSDPIS--RTLRFSLV--NDSEGWLCIEKFSGEVHTAQSL-QGAQPGD 630
+ G+ + I +D S +R+S++ +D E I+ G +HTA L + A+
Sbjct: 386 NKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWH 445
Query: 631 TYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLI--VSG 688
TVL A + D ++ + I L A LA ++C LI +
Sbjct: 446 NLTVL--ATELDSSAQASRVQVAIQTLDEND-NAPQLAEPYDTFVCDSAAPGQLIQVIRA 502
Query: 689 PSKDPDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPRE--HIIPVVV 746
+D S H + LGP+ ++ +Q A L L PR +++P+ +
Sbjct: 503 LDRDEVGNSSHVSFQGPLGPD----ANFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIEL 558
Query: 747 ---SHNAQMWQLLVRVIVCRCNVEG---QCMRKVGRMKGMPTKLSAVGILVGTLVAI--- 797
A V V VCRC +G C + LSA G+ G L+AI
Sbjct: 559 WDWGQPALSSTATVTVSVCRCQPDGSVASCWPE--------AHLSAAGLSTGALLAIITC 610
Query: 798 -GIFLILIFTHWTMSRKK 814
G L L+ + R+K
Sbjct: 611 VGALLALVVLFVALRRQK 628
Score = 113 bits (283), Expect = 6e-25
Identities = 140/569 (24%), Positives = 232/569 (40%), Gaps = 77/569 (13%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E Y G P+ + KL + EG+ +L+G+ F +D +G + VT++LDR
Sbjct: 53 VIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTV---FVIDEATGNIHVTKSLDR 109
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EE+A+Y L ++ L P ++ V+D ND P F Y A + + G
Sbjct: 110 EEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSV 169
Query: 146 LFLEASDRDEPGTANS-DLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALE 204
+ + A D D+P NS L + +L P F ++P+ G + + ++D +
Sbjct: 170 IQVTAHDADDPSYGNSAKLVYTVLDGLP------FFSVDPQTGVVRTA---IPNMDRETQ 220
Query: 205 RTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWS 264
+ +++Q KDMG G + TV V++ + V+ P ++ LY + +
Sbjct: 221 EEFLVVIQAKDMGGHMGGLSGSTTVTVTLSD---VNDNPPKFPQS---LYQFSVVETAGP 274
Query: 265 G-------------GD----VHYHLESHPPGPFEVNA-----EGNLYVTRELDREAQAEY 302
G GD + L+ F ++ +G L V + LD E+Q Y
Sbjct: 275 GTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSY 334
Query: 303 LLQVRAQNS-------HGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEV 355
+V A N+ + + V V D + P +++PE PGT V
Sbjct: 335 SFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPE-PPAFTQAAYHLTVPENKAPGTLV 393
Query: 356 TRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPL----RAGQ 411
++SA D D+P SP + + PE R F + P G++ PL RA
Sbjct: 394 GQISAADLDSPASPIRYSILPHSDPE-------RCFSIQPEEGTIHTAA-PLDREARAWH 445
Query: 412 NILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAM 471
N+ +L +D + +S +V + D ND+AP+ ++ + + PG L+ +
Sbjct: 446 NLTVLATELDSSAQ----ASRVQVAIQTLDENDNAPQL--AEPYDTFVCDSAAPGQLIQV 499
Query: 472 LTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVV 531
+ A+D D + F G D S + L S A P H +V
Sbjct: 500 IRALDRDEVGNSSHVSFQGPLGPDANFTVQDNRDGSASLLLP-----SRPAPPRHAPYLV 554
Query: 532 VQSVAKLVGPGPGPGATATVTVLVERVMP 560
+ P +TATVTV V R P
Sbjct: 555 --PIELWDWGQPALSSTATVTVSVCRCQP 581
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 151 bits (381), Expect = 3e-36
Identities = 148/548 (27%), Positives = 244/548 (44%), Gaps = 34/548 (6%)
Query: 286 GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAP-LELHVLVMDENDNVPICPPRDPTVS 344
G+++ T+ LDRE QA Y L+ +A + P E + + D NDN P T
Sbjct: 102 GDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAG 161
Query: 345 IPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPEPEDGVEGRAFQVDPTSGSV--T 401
+PE+SP GT V +++A DAD P NS VVY +L +P F V+P +G +
Sbjct: 162 VPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP-------YFSVEPKTGVIKTA 214
Query: 402 LGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPE 461
L + A LL++ A D+ G GG S T V V +TD+ND+ P F + ++PE
Sbjct: 215 LPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRF-PRRSYQYNVPE 273
Query: 462 DVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYE 521
+ ++VA + A DAD+ A M++ I GD G F + + ++ + + K L +E
Sbjct: 274 SLPVASVVARIKAADADI-GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFE 332
Query: 522 AAPSHEVVVVVQSVAKLVGP---GPGP-GATATVTVLVERVMPPPKLDQESYEASVPISA 577
A S+ + +++ K P GP T TV ++VE V PP Y V +
Sbjct: 333 AKTSY--TLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEAT 390
Query: 578 PAGSFLLTIQPSDPISRT--LRFSL--VNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYT 633
G+ + T+ DP S +R+S+ D E + I+ SG + TA+SL + +
Sbjct: 391 QVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLD-RETNAIHN 449
Query: 634 VLVEAQDTDEPRLSASAPLVIHFLKA-PPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKD 692
+ V A ++ P + I L AP + + +C Q +I + D
Sbjct: 450 ITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETT--VCENAQPGQVIQKISAVD 507
Query: 693 PDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPRE---HIIPVVVSHN 749
D S + F+L + T ++ L+ + A + + +E + +P+ + +
Sbjct: 508 KDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDS 567
Query: 750 AQ---MWQLLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIGIFLILIFT 806
+ + VC C+ +G +P LS G L+ L + L+LI
Sbjct: 568 GSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLS-TGALIAILACVLTLLVLILL 626
Query: 807 HWTMSRKK 814
TM R+K
Sbjct: 627 IVTMRRRK 634
Score = 115 bits (287), Expect = 2e-25
Identities = 124/489 (25%), Positives = 218/489 (44%), Gaps = 67/489 (13%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E Y G+ PLY+ KL + +G I +LSG+ + F +D ++G + T+ LDR
Sbjct: 56 VLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSI---FIIDENTGDIHATKRLDR 112
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EEQA Y L+ L+ + ++ ++D ND P F Y A + + G
Sbjct: 113 EEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSV 172
Query: 146 LFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER 205
+ + A+D D+P NS + + Q QP F +EP+ G + + ++D +
Sbjct: 173 VQVTATDADDPTYGNSARVVYSILQ--GQP---YFSVEPKTGVIKTA---LPNMDREAKD 224
Query: 206 TYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEP---------IHLAENLKVLYPH 256
Y L++Q KDM Q G T +V V++ T V+ P ++ E+L V
Sbjct: 225 QYLLVIQAKDMVGQNGGLSGTTSVTVTL---TDVNDNPPRFPRRSYQYNVPESLPV--AS 279
Query: 257 HMAQVHWSGGDVHYHLESHPP-------GPFEVNA-----EGNLYVTRELDREAQAEYLL 304
+A++ + D+ + E G F+++ EG + + +ELD EA+ Y L
Sbjct: 280 VVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTL 339
Query: 305 QVRAQNSHGE-------DYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTR 357
++ A N + ++ + ++V D ++ P P + + E + G +
Sbjct: 340 RIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYP-MEVSEATQVGNIIGT 398
Query: 358 LSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGV---LPLRAGQNIL 414
++A D D+ SP + + + E R F +D SG +T A NI
Sbjct: 399 VAAHDPDSSNSPVRYSIDRNTDLE-------RYFNIDANSGVITTAKSLDRETNAIHNIT 451
Query: 415 LLVLAMDLAGAEG-GFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLT 473
+L + G G+ V + + DIND+APEF ++ E+ +PG ++ ++
Sbjct: 452 VLAMESQNPSQVGRGY-----VAITILDINDNAPEFAMDY--ETTVCENAQPGQVIQKIS 504
Query: 474 AIDADLEPA 482
A+D D EP+
Sbjct: 505 AVDKD-EPS 512
Score = 55.8 bits (133), Expect = 2e-07
Identities = 103/459 (22%), Positives = 177/459 (38%), Gaps = 54/459 (11%)
Query: 47 PREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRA-LDREEQAEYQLQVTLEMQDGHV 105
P G ++V S G+ F+++P +G + +DRE + +Y L + + G
Sbjct: 183 PTYGNSARVVYSILQGQPY---FSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQN 239
Query: 106 --LWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDL 163
L G V V + D ND P F + Y+ + ++A+D D AN+++
Sbjct: 240 GGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADI--GANAEM 297
Query: 164 RFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQV--KDMGDQ-- 219
+ I+ E + G + + + LD + +Y L ++ KD +
Sbjct: 298 EYKIVDGDGLGIFKISVDKETQEGIITIQKE----LDFEAKTSYTLRIEAANKDADPRFL 353
Query: 220 ASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSG---GDVHYHLESHP 276
+ G + T I+E V P+ + LYP +++ G G V H
Sbjct: 354 SLGPFSDTTTVKIIVED--VDEPPVFSSP----LYPMEVSEATQVGNIIGTVAAHDPDSS 407
Query: 277 PGP--------------FEVNAEGNLYVT-RELDREAQAEYLLQVRAQNSHGEDYAAPLE 321
P F ++A + T + LDRE A + + V A S
Sbjct: 408 NSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGY 467
Query: 322 LHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPE 381
+ + ++D NDN P D ++ E + PG + ++SA D D P N H Y L+
Sbjct: 468 VAITILDINDNAPEF-AMDYETTVCENAQPGQVIQKISAVDKDEPS--NGHQFYFSLT-- 522
Query: 382 PEDGVEGRAFQVDPTSGSVTLGVLPLRAG-----QNILLLVLAMDLAGAEGGFSSTCEVE 436
D F + + T +L R G Q++ L + + +G+ SST +
Sbjct: 523 -TDATNNHNFSLKDNKDN-TASILTRRNGFRRQEQSVYYLPIFIVDSGSP-SLSSTNTLT 579
Query: 437 VAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAI 475
+ V D D T LP + G L+A+L +
Sbjct: 580 IRVCDC-DADGVAQTCNAEAYVLPAGLSTGALIAILACV 617
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 151 bits (381), Expect = 3e-36
Identities = 148/548 (27%), Positives = 244/548 (44%), Gaps = 34/548 (6%)
Query: 286 GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAP-LELHVLVMDENDNVPICPPRDPTVS 344
G+++ T+ LDRE QA Y L+ +A + P E + + D NDN P T
Sbjct: 102 GDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAG 161
Query: 345 IPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPEPEDGVEGRAFQVDPTSGSV--T 401
+PE+SP GT V +++A DAD P NS VVY +L +P F V+P +G +
Sbjct: 162 VPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP-------YFSVEPKTGVIKTA 214
Query: 402 LGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPE 461
L + A LL++ A D+ G GG S T V V +TD+ND+ P F + ++PE
Sbjct: 215 LPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRF-PRRSYQYNVPE 273
Query: 462 DVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYE 521
+ ++VA + A DAD+ A M++ I GD G F + + ++ + + K L +E
Sbjct: 274 SLPVASVVARIKAADADI-GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFE 332
Query: 522 AAPSHEVVVVVQSVAKLVGP---GPGP-GATATVTVLVERVMPPPKLDQESYEASVPISA 577
A S+ + +++ K P GP T TV ++VE V PP Y V +
Sbjct: 333 AKTSY--TLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEAT 390
Query: 578 PAGSFLLTIQPSDPISRT--LRFSL--VNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYT 633
G+ + T+ DP S +R+S+ D E + I+ SG + TA+SL + +
Sbjct: 391 QVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLD-RETNAIHN 449
Query: 634 VLVEAQDTDEPRLSASAPLVIHFLKA-PPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKD 692
+ V A ++ P + I L AP + + +C Q +I + D
Sbjct: 450 ITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETT--VCENAQPGQVIQKISAVD 507
Query: 693 PDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPRE---HIIPVVVSHN 749
D S + F+L + T ++ L+ + A + + +E + +P+ + +
Sbjct: 508 KDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDS 567
Query: 750 AQ---MWQLLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIGIFLILIFT 806
+ + VC C+ +G +P LS G L+ L + L+LI
Sbjct: 568 GSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLS-TGALIAILACVLTLLVLILL 626
Query: 807 HWTMSRKK 814
TM R+K
Sbjct: 627 IVTMRRRK 634
Score = 115 bits (287), Expect = 2e-25
Identities = 124/489 (25%), Positives = 218/489 (44%), Gaps = 67/489 (13%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E Y G+ PLY+ KL + +G I +LSG+ + F +D ++G + T+ LDR
Sbjct: 56 VLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSI---FIIDENTGDIHATKRLDR 112
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EEQA Y L+ L+ + ++ ++D ND P F Y A + + G
Sbjct: 113 EEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSV 172
Query: 146 LFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER 205
+ + A+D D+P NS + + Q QP F +EP+ G + + ++D +
Sbjct: 173 VQVTATDADDPTYGNSARVVYSILQ--GQP---YFSVEPKTGVIKTA---LPNMDREAKD 224
Query: 206 TYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEP---------IHLAENLKVLYPH 256
Y L++Q KDM Q G T +V V++ T V+ P ++ E+L V
Sbjct: 225 QYLLVIQAKDMVGQNGGLSGTTSVTVTL---TDVNDNPPRFPRRSYQYNVPESLPV--AS 279
Query: 257 HMAQVHWSGGDVHYHLESHPP-------GPFEVNA-----EGNLYVTRELDREAQAEYLL 304
+A++ + D+ + E G F+++ EG + + +ELD EA+ Y L
Sbjct: 280 VVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTL 339
Query: 305 QVRAQNSHGE-------DYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTR 357
++ A N + ++ + ++V D ++ P P + + E + G +
Sbjct: 340 RIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYP-MEVSEATQVGNIIGT 398
Query: 358 LSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGV---LPLRAGQNIL 414
++A D D+ SP + + + E R F +D SG +T A NI
Sbjct: 399 VAAHDPDSSNSPVRYSIDRNTDLE-------RYFNIDANSGVITTAKSLDRETNAIHNIT 451
Query: 415 LLVLAMDLAGAEG-GFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLT 473
+L + G G+ V + + DIND+APEF ++ E+ +PG ++ ++
Sbjct: 452 VLAMESQNPSQVGRGY-----VAITILDINDNAPEFAMDY--ETTVCENAQPGQVIQKIS 504
Query: 474 AIDADLEPA 482
A+D D EP+
Sbjct: 505 AVDKD-EPS 512
Score = 55.8 bits (133), Expect = 2e-07
Identities = 103/459 (22%), Positives = 177/459 (38%), Gaps = 54/459 (11%)
Query: 47 PREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRA-LDREEQAEYQLQVTLEMQDGHV 105
P G ++V S G+ F+++P +G + +DRE + +Y L + + G
Sbjct: 183 PTYGNSARVVYSILQGQPY---FSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQN 239
Query: 106 --LWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDL 163
L G V V + D ND P F + Y+ + ++A+D D AN+++
Sbjct: 240 GGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADI--GANAEM 297
Query: 164 RFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQV--KDMGDQ-- 219
+ I+ E + G + + + LD + +Y L ++ KD +
Sbjct: 298 EYKIVDGDGLGIFKISVDKETQEGIITIQKE----LDFEAKTSYTLRIEAANKDADPRFL 353
Query: 220 ASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSG---GDVHYHLESHP 276
+ G + T I+E V P+ + LYP +++ G G V H
Sbjct: 354 SLGPFSDTTTVKIIVED--VDEPPVFSSP----LYPMEVSEATQVGNIIGTVAAHDPDSS 407
Query: 277 PGP--------------FEVNAEGNLYVT-RELDREAQAEYLLQVRAQNSHGEDYAAPLE 321
P F ++A + T + LDRE A + + V A S
Sbjct: 408 NSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGY 467
Query: 322 LHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPE 381
+ + ++D NDN P D ++ E + PG + ++SA D D P N H Y L+
Sbjct: 468 VAITILDINDNAPEF-AMDYETTVCENAQPGQVIQKISAVDKDEPS--NGHQFYFSLT-- 522
Query: 382 PEDGVEGRAFQVDPTSGSVTLGVLPLRAG-----QNILLLVLAMDLAGAEGGFSSTCEVE 436
D F + + T +L R G Q++ L + + +G+ SST +
Sbjct: 523 -TDATNNHNFSLKDNKDN-TASILTRRNGFRRQEQSVYYLPIFIVDSGSP-SLSSTNTLT 579
Query: 437 VAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAI 475
+ V D D T LP + G L+A+L +
Sbjct: 580 IRVCDC-DADGVAQTCNAEAYVLPAGLSTGALIAILACV 617
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 146 bits (368), Expect = 9e-35
Identities = 157/579 (27%), Positives = 254/579 (43%), Gaps = 51/579 (8%)
Query: 266 GDVHYHLESHPPGPFEVNAE--GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAP-LEL 322
G + Y L G + E G+++ TR +DRE +A Y L+ +A N P E
Sbjct: 87 GSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEF 146
Query: 323 HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPE 381
+ + D NDN P P T S+PE+S GT V +++A DAD P NS V+Y +L +
Sbjct: 147 VIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQ 206
Query: 382 PEDGVEGRAFQVDPTSGSVTLGVLPLRAGQN---ILLLVLAMDLAGAEGGFSSTCEVEVA 438
P F V+P +G + LP +N +++ A D+ G GG S T V +
Sbjct: 207 P-------YFSVEPETGIIRT-ALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNIT 258
Query: 439 VTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD----LEPAFRLMDFAIERGD 494
+TD+ND+ P F + I + + E GT + + A DAD E +R++D GD
Sbjct: 259 LTDVNDNPPRFPQNTI-HLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIID-----GD 312
Query: 495 TEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSV---AKLVGPGPGPGATATV 551
F + E D+ + + K L YE+ + + V ++ + GP T V
Sbjct: 313 GTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKD-TTIV 371
Query: 552 TVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDP--ISRTLRFSL--VNDSEGW 607
+ +E V PP + SY V G+ + T+ DP IS +RFSL D +
Sbjct: 372 KISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRI 431
Query: 608 LCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTL 667
I +G ++T++ L + + + V A + + P+ + + + L A
Sbjct: 432 FNIHSGNGSLYTSKPLD-RELSQWHNLTVIAAEINNPKETTRVAVFVRILDVND-NAPQF 489
Query: 668 APVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTL---GPNPTVQ--RDWRLQTLN 722
A ++C + LI + + D D G + F+L PN TVQ D + L
Sbjct: 490 AVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILT 549
Query: 723 GSHAYLTLALHWVEPREHIIPVVVSHN---AQMWQLLVRVIVCRCNVEGQCMRKVGRMKG 779
+ + + E +++PVV+S N Q + + VC C+ +G
Sbjct: 550 RKNGF-----NRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALL 604
Query: 780 MPTKLSAVGILVGTLVAIGIFLILI--FTHWTMSRKKDP 816
+P LS G L+ L+ I I L+++ F RKK+P
Sbjct: 605 LPAGLS-TGALIAILLCIIILLVIVVLFAALKRQRKKEP 642
Score = 106 bits (265), Expect = 8e-23
Identities = 120/477 (25%), Positives = 209/477 (43%), Gaps = 54/477 (11%)
Query: 31 ENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDREE 88
E Y G+ Y+ KL ++ +G + +LSGD F +D +G + TR +DREE
Sbjct: 65 EEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTL---FIIDEKTGDIHATRRIDREE 121
Query: 89 QAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLF 147
+A Y L+ + + + ++ + D ND P F + IY A + + G +
Sbjct: 122 KAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQ 181
Query: 148 LEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTY 207
+ A+D D+P NS + + Q QP F +EP G + + +++ Y
Sbjct: 182 VTATDADDPSYGNSARVIYSILQG--QP---YFSVEPETGIIRTA---LPNMNRENREQY 233
Query: 208 QLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAEN---LKVLYPHHMAQVHWS 264
Q+++Q KDMG Q G T TV +++ T V+ P +N L+VL + S
Sbjct: 234 QVVIQAKDMGGQMGGLSGTTTVNITL---TDVNDNPPRFPQNTIHLRVLESSPVGTAIGS 290
Query: 265 ----------GGDVHYH-LESHPPGPFEV-----NAEGNLYVTRELDREAQAEYLLQVRA 308
+V Y ++ F++ EG + V + LD E++ Y L+V A
Sbjct: 291 VKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEA 350
Query: 309 QNSHGED---YAAPLELHVLV---MDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAED 362
+N+H + Y P + +V +++ D P+ + E GT + + A D
Sbjct: 351 ENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARD 410
Query: 363 ADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLVLAMD 421
D+ SP + + L D R F + +GS+ T L Q L V+A +
Sbjct: 411 PDSISSP---IRFSLDRHTDLD----RIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAE 463
Query: 422 LAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD 478
+ + ++ V V + D+ND+AP+F + + E+ PG L+ ++A+D D
Sbjct: 464 INNPKE--TTRVAVFVRILDVNDNAPQF--AVFYDTFVCENARPGQLIQTISAVDKD 516
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 145 bits (367), Expect = 1e-34
Identities = 143/571 (25%), Positives = 247/571 (43%), Gaps = 32/571 (5%)
Query: 266 GDVHYHLESHPPGP-FEVN-AEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAP-LEL 322
G V Y L G F ++ G+++ R LDRE + Y L+ +A + P E
Sbjct: 87 GTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEF 146
Query: 323 HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPE 381
+ V D NDN P ++PE+SP G V ++ A DAD P NS VVY +L +
Sbjct: 147 IIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ 206
Query: 382 PEDGVEGRAFQVDPTSGSV--TLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAV 439
P F +DP +G + L + + +L+ A D+ G GG + T V + +
Sbjct: 207 P-------YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITL 259
Query: 440 TDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTF 499
TD+ND+ P F S I + +PE G+ + + A+D D + ++ I GD F
Sbjct: 260 TDVNDNPPRFPKS-IFHLKVPESSPIGSAIGRIRAVDPDFGQNAEI-EYNIVPGDGGNLF 317
Query: 500 GLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSV---AKLVGPGPGPGATATVTVLVE 556
+ + D+ ++L K L +E ++ V ++ + GP TATV + V
Sbjct: 318 DIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKD-TATVKISVL 376
Query: 557 RVMPPPKLDQESYEASVPISAPAGSFL--LTIQPSDPISRTLRFSL--VNDSEGWLCIEK 612
V PP + Y V P G+ + +T Q D S +R+ + +D + + I+
Sbjct: 377 DVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDG 436
Query: 613 FSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPS 672
G + T + L Y + A P L++ ++I+ L P P +
Sbjct: 437 NEGTIATNELLDRESTAQ-YNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYET 495
Query: 673 QYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLAL 732
+C + +I + D DL+ +SF L P ++ ++ ++ + A +
Sbjct: 496 A-VCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRR 554
Query: 733 HWVEPRE---HIIPVVV---SHNAQMWQLLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSA 786
+ R+ + +PVV+ S+ Q + + VCRC+ +G + +P LS
Sbjct: 555 NGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLS- 613
Query: 787 VGILVGTLVAIGIFLILIFTHWTMSRKKDPD 817
G L+ L+ I I L ++ + + R+K D
Sbjct: 614 TGALIAILLCIVILLAIVVLYVALRRQKKKD 644
Score = 105 bits (263), Expect = 1e-22
Identities = 119/494 (24%), Positives = 214/494 (43%), Gaps = 60/494 (12%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E Y G+ P Y+ KL + EG + LSGD F +D +G + R+LDR
Sbjct: 63 VLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTV---FTIDETTGDIHAIRSLDR 119
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EE+ Y L+ ++++ L ++ V+D ND P F Y A + + G
Sbjct: 120 EEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYV 179
Query: 146 LFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER 205
L ++A+D D+P NS + + Q QP F ++P+ G + + ++D ++
Sbjct: 180 LQVKATDADDPTYGNSARVVYSILQG--QP---YFSIDPKTGVIRTA---LPNMDREVKE 231
Query: 206 TYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSG 265
YQ+L+Q KDMG Q G T V +++ T V+ P +++ L + + +
Sbjct: 232 QYQVLIQAKDMGGQLGGLAGTTIVNITL---TDVNDNPPRFPKSIFHLKVPESSPIGSAI 288
Query: 266 G-------------DVHYHLESHPPGPF------EVNAEGNLYVTRELDREAQAEYLLQV 306
G ++ Y++ G E EG + + + LD E + Y +V
Sbjct: 289 GRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKV 348
Query: 307 RAQNSHGEDY---------AAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTR 357
A N H + A +++ VL +DE P+ T+ + E +P GT +
Sbjct: 349 EASNLHLDHRFHSAGPFKDTATVKISVLDVDE---PPVFSKPLYTMEVYEDTPVGTIIGA 405
Query: 358 LSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLL 416
++A+D D S + + DG F +D G++ T +L +
Sbjct: 406 VTAQDLDVGSSAVRYFI-----DWKSDG--DSYFTIDGNEGTIATNELLDRESTAQYNFS 458
Query: 417 VLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAID 476
++A ++ +S + + V D+N+ PE S ++ E+ +PG ++ +++A D
Sbjct: 459 IIASKVSNPL--LTSKVNILINVLDVNEFPPEI--SVPYETAVCENAKPGQIIQIVSAAD 514
Query: 477 ADLEPAFRLMDFAI 490
DL PA + F +
Sbjct: 515 RDLSPAGQQFSFRL 528
Score = 56.6 bits (135), Expect = 9e-08
Identities = 98/460 (21%), Positives = 182/460 (39%), Gaps = 56/460 (12%)
Query: 47 PREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRA-LDREEQAEYQLQVTLEMQDGHV 105
P G ++V S G+ F++DP +G + +DRE + +YQ+ + + G +
Sbjct: 190 PTYGNSARVVYSILQGQPY---FSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQL 246
Query: 106 --LWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDL 163
L G V + + D ND P F ++I+ ++ + G + A D D N+++
Sbjct: 247 GGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPD--FGQNAEI 304
Query: 164 RFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGH 223
++I+ + + + G + L LD ++ Y V+ ++ H
Sbjct: 305 EYNIVPGDGGNLFDIVTDEDTQEGVIKL----KKPLDFETKKAYTFKVEASNLHLDHRFH 360
Query: 224 QA-----TATVEVSI--IESTWVSLEPIH-----------------LAENLKVLYPHHMA 259
A TATV++S+ ++ V +P++ A++L V
Sbjct: 361 SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY 420
Query: 260 QVHW-SGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAA 318
+ W S GD ++ ++ + EG + LDRE+ A+Y + A +
Sbjct: 421 FIDWKSDGDSYFTIDGN---------EGTIATNELLDRESTAQYNFSIIASKVSNPLLTS 471
Query: 319 PLELHVLVMDENDNVP-ICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQL 377
+ + + V+D N+ P I P + V E + PG + +SA D D SP
Sbjct: 472 KVNILINVLDVNEFPPEISVPYETAVC--ENAKPGQIIQIVSAADRDL--SPAGQQFSFR 527
Query: 378 LSPEP--EDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEV 435
LSPE + R F+ + R + L V+ D + ++T +
Sbjct: 528 LSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTI 587
Query: 436 EVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAI 475
V D + ++ + I LP + G L+A+L I
Sbjct: 588 RVCRCDSDG---TILSCNVEAIFLPVGLSTGALIAILLCI 624
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 144 bits (363), Expect = 3e-34
Identities = 163/593 (27%), Positives = 248/593 (41%), Gaps = 85/593 (14%)
Query: 284 AEGNLYVTRELDREAQAEYLLQVRA-QNSHGEDYAAPLELHVLVMDENDNVPICPPRDPT 342
A GN++VT+ LDRE +A+Y+L +A + P E + V D NDN PI P
Sbjct: 97 ATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYH 156
Query: 343 VSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPEPEDGVEGRAFQVDPTSGSVT 401
++PE+S GT V +++A DAD P NS +VY +L P F VDP +G V
Sbjct: 157 ATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLP-------FFSVDPQTGVVR 209
Query: 402 LGV--LPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISL 459
+ + + L+++ A D+ G GG S + V V ++D+ND+ P+F S + S+
Sbjct: 210 TAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQS-LYQFSV 268
Query: 460 PEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLS 519
E PGTLV L A D DL LM ++I G+ F + + L + K L
Sbjct: 269 VETAGPGTLVGRLRAQDPDLGDN-ALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLD 327
Query: 520 YEAAPSHEVVVVVQSVAKLVGPG---PGP-GATATVTVLVERVMPPPKLDQESYEASVPI 575
+E+ S+ V++ L+ P GP A+V V V+ PP Q +Y +VP
Sbjct: 328 FESQRSYS--FRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPE 385
Query: 576 SAPAGSFLLTIQPSDPIS--RTLRFSLV--NDSEGWLCIEKFSGEVHTAQSL-QGAQPGD 630
+ G+ + I +D S +R+S++ +D E I+ G +HTA L + A+
Sbjct: 386 NKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWH 445
Query: 631 TYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAP--------------------------- 663
TVL PL++ AP AP
Sbjct: 446 NLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQASRVQVAI 505
Query: 664 --------ALTLAPVPSQYLCTPRQDHGLI--VSGPSKDPDLASGHGPYSFTLGPNPTVQ 713
A LA ++C LI + +D S H + LGP+
Sbjct: 506 QTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPD---- 561
Query: 714 RDWRLQTLNGSHAYLTLALHWVEPRE--HIIPVVV---SHNAQMWQLLVRVIVCRCNVEG 768
++ +Q A L L PR +++P+ + A V V VCRC +G
Sbjct: 562 ANFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIELWDWGQPALSSTATVTVSVCRCQPDG 621
Query: 769 ---QCMRKVGRMKGMPTKLSAVGILVGTLVAI----GIFLILIFTHWTMSRKK 814
C + LSA G+ G L+AI G L L+ + R+K
Sbjct: 622 SVASCWPE--------AHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQK 666
Score = 102 bits (253), Expect = 2e-21
Identities = 144/602 (23%), Positives = 234/602 (38%), Gaps = 105/602 (17%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E Y G P+ + KL + EG+ +L+G+ F +D +G + VT++LDR
Sbjct: 53 VIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTV---FVIDEATGNIHVTKSLDR 109
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EE+A+Y L ++ L P ++ V+D ND P F Y A + + G
Sbjct: 110 EEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSV 169
Query: 146 LFLEASDRDEPGTANS-DLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALE 204
+ + A D D+P NS L + +L P F ++P+ G + + ++D +
Sbjct: 170 IQVTAHDADDPSYGNSAKLVYTVLDGLP------FFSVDPQTGVVRTA---IPNMDRETQ 220
Query: 205 RTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWS 264
+ +++Q KDMG G + TV V++ + V+ P ++ LY + +
Sbjct: 221 EEFLVVIQAKDMGGHMGGLSGSTTVTVTLSD---VNDNPPKFPQS---LYQFSVVETAGP 274
Query: 265 G-------------GD----VHYHLESHPPGPFEVNA-----EGNLYVTRELDREAQAEY 302
G GD + L+ F ++ +G L V + LD E+Q Y
Sbjct: 275 GTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSY 334
Query: 303 LLQVRAQNS-------HGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEV 355
+V A N+ + + V V D + P +++PE PGT V
Sbjct: 335 SFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPE-PPAFTQAAYHLTVPENKAPGTLV 393
Query: 356 TRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNIL 414
++SA D D+P SP + + PE R F + P G++ T L A
Sbjct: 394 GQISAADLDSPASPIRYSILPHSDPE-------RCFSIQPEEGTIHTAAPLDREARAWHN 446
Query: 415 LLVLAMDLA---GAEGGF---------------------------------SSTCEVEVA 438
L VLA +L G E G+ +S +V +
Sbjct: 447 LTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQASRVQVAIQ 506
Query: 439 VTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGT 498
D ND+AP+ ++ + + PG L+ ++ A+D D + F G
Sbjct: 507 TLDENDNAPQL--AEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPDANF 564
Query: 499 FGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERV 558
D S + L S A P H +V + P +TATVTV V R
Sbjct: 565 TVQDNRDGSASLLLP-----SRPAPPRHAPYLV--PIELWDWGQPALSSTATVTVSVCRC 617
Query: 559 MP 560
P
Sbjct: 618 QP 619
Score = 54.3 bits (129), Expect = 5e-07
Identities = 135/563 (23%), Positives = 219/563 (38%), Gaps = 95/563 (16%)
Query: 69 FAMDPDSGFLLVTRA-LDREEQAEYQLQVTLEMQDGHV--LWGPQPVLVHVKDENDQVPH 125
F++DP +G + +DRE Q E+ + + + GH+ L G V V + D ND P
Sbjct: 199 FSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPK 258
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F Q++Y+ + PG L A D D N+ + + IL ++ L+ R
Sbjct: 259 FPQSLYQFSVVETAGPGTLVGRLRAQDPDLGD--NALMAYSILDGEGSEAFSISTDLQGR 316
Query: 186 LGALALSPKGSTSLDHALERTYQLLVQVKD-MGDQA----SGHQATATVEVSII---EST 237
G L + LD +R+Y V+ + + D A + A+V V++ E
Sbjct: 317 DGLLTVRKP----LDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPP 372
Query: 238 WVSLEPIHLA--ENLK---VLYPHHMAQVHWSGGDVHYHLESH--PPGPFEVNAE-GNLY 289
+ HL EN ++ A + + Y + H P F + E G ++
Sbjct: 373 AFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIH 432
Query: 290 VTRELDREAQAEYLLQVRAQN---SHGED----------YAAP----------------- 319
LDREA+A + L V A S G + ++AP
Sbjct: 433 TAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQ 492
Query: 320 --------LELHVLVMDENDNVP-ICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPN 370
+++ + +DENDN P + P D V + + PG + + A D D G+ +
Sbjct: 493 DSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVC--DSAAPGQLIQVIRALDRDEVGN-S 549
Query: 371 SHVVYQ-LLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAG--QNILLLVLAMDLAGAEG 427
SHV +Q L P+ V+ D GS +L +LP R ++ LV +
Sbjct: 550 SHVSFQGPLGPDANFTVQ------DNRDGSASL-LLPSRPAPPRHAPYLVPIELWDWGQP 602
Query: 428 GFSSTCEVEVAVT------DINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEP 481
SST V V+V + PE S G + G L+A++T + A L
Sbjct: 603 ALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAG-------LSTGALLAIITCVGALL-- 653
Query: 482 AFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGP 541
A ++ A+ R E L+ E ++ + E + + + +Q+ P
Sbjct: 654 ALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFD-ITALQNPDGAAPP 712
Query: 542 GPGPGATATV--TVLVERVMPPP 562
PGP A V V R PP
Sbjct: 713 APGPPARRDVLPRARVSRQPRPP 735
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 140 bits (352), Expect = 6e-33
Identities = 167/648 (25%), Positives = 271/648 (41%), Gaps = 77/648 (11%)
Query: 42 TKLPLPREGAEGQIVLSGDSGKATEG----PFAMDPDSGFLLVTRALDREEQAEYQLQVT 97
T++ L R G ++ S G E F +D SG L + ++LD E YQ +
Sbjct: 2720 TEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSIL 2779
Query: 98 LEM-QDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEP 156
QD H + V + VKD ND P F + Y A + G + + ASD D
Sbjct: 2780 ARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADS- 2838
Query: 157 GTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDM 216
GT + + L Q+ + + F + G + + LDH YQ+ V D
Sbjct: 2839 GTNGQVM--YSLDQSQSVEVIESFAINMETGWITTLKE----LDHEKRDNYQIKVVASDH 2892
Query: 217 GDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDV-------- 268
G++ +TA V+V++ + P AE +Y +++ GG +
Sbjct: 2893 GEKIQ-LSSTAIVDVTVTDVN--DSPPRFTAE----IYKGTVSEDDPQGGVIAILSTTDA 2945
Query: 269 ----------HYHLESHPPGPFEVNA---EGNLYVTRELDREAQAEYLLQVRAQNSHGED 315
++ P G F V E +YV + LDRE + YLL + A +
Sbjct: 2946 DSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG---T 3002
Query: 316 YAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVY 375
+++ + V V+D NDN P+C + +IPE PG + ++SA DAD N+ + Y
Sbjct: 3003 FSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADI--RSNAEITY 3060
Query: 376 QLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNIL-LLVLAMDLAGAEGGFSSTCE 434
LL G F+++P +G + R Q + LLV A D GG
Sbjct: 3061 TLL------GSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATD----GGGRFCQAS 3110
Query: 435 VEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGD 494
+ + + D+ND+APEF I++ E+ EPGTL+ + A DAD +++ I+ D
Sbjct: 3111 IVLTLEDVNDNAPEFSADPYA-ITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSAD 3169
Query: 495 TEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVL 554
G F ++ L + E E+ V K V G TAT TV+
Sbjct: 3170 --GQFSIN----------ELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVI 3217
Query: 555 VERV---MPPPKLDQESYEASVPISAPAGSFLLTIQPSD---PISRTLRFSLVNDSE-GW 607
V + PP + Y A+V G+ +L + + + + +S+++ +E G
Sbjct: 3218 VSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGK 3277
Query: 608 LCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIH 655
I+ +G V ++L + Y + VEA D P LS A + ++
Sbjct: 3278 FSIDSKTGAVFIIENLD-YESSHEYYLTVEATDGGTPSLSDVATVNVN 3324
Score = 110 bits (276), Expect = 4e-24
Identities = 162/710 (22%), Positives = 280/710 (39%), Gaps = 64/710 (9%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQ 128
F +DP +G L + LD E ++ L V + QD V ++V+V D ND P F+
Sbjct: 1505 FRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTA 1564
Query: 129 AIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGA 188
+ Y+ R+ G L + A D+D+ A +L + + F ++P LG+
Sbjct: 1565 SSYKGRVYESAAVGSVVLQVTALDKDKGKNA------EVLYSIESGNIGNSFMIDPVLGS 1618
Query: 189 LALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIEST---WVSLE-PI 244
+ K + LD + + Y L+V+ D G + + V+I ++ + S E +
Sbjct: 1619 I----KTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSV 1674
Query: 245 HLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRE-LDREAQAEYL 303
L+E + + M H V+ + + F++N +T++ LD E Y
Sbjct: 1675 ELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYT 1734
Query: 304 LQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEV-----TRL 358
L ++ N G + +H + DENDN P+ + T I E + + V L
Sbjct: 1735 LIIQGTNMAGLSTNTTVLVH--LQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPL 1792
Query: 359 SAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLV 417
ADA N+ +VY ++ P F +D ++G++ T+ L V
Sbjct: 1793 VIRAADADKDSNALLVYHIVEPSVH-----TYFAIDSSTGAIHTVLSLDYEETSIFHFTV 1847
Query: 418 LAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDA 477
D+ V V V DIND P F + SL G V + A DA
Sbjct: 1848 QVHDMGTPRLFAEYAANVTVHVIDINDCPPVF-AKPLYEASLLLPTYKGVKVITVNATDA 1906
Query: 478 DLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAK 537
D AF + ++I G+ F +D++ + V+ YE +
Sbjct: 1907 D-SSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYE-------------LTV 1952
Query: 538 LVGPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQP-SDPISRTL 596
G G T+ + E K Q+ Y A V ++ L I +PI+ L
Sbjct: 1953 RASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPL 2012
Query: 597 RFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHF 656
+ ++N + I + SG + T + + + + V+VE T+E + SA A +V+
Sbjct: 2013 FYHILNPDRRFK-ISRTSGVLSTTGTPFDREQQEAFDVVVEV--TEEHKPSAVAHVVVKV 2069
Query: 657 L---KAPPAPALTLAPVPSQYLCTPRQDHGL-IVSGPSKDPDLASGHGPY-------SFT 705
+ + AP P + H + V+ +D +G Y F
Sbjct: 2070 IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSG-RNGEVHYYLKEHHEHFQ 2128
Query: 706 LGP--NPTVQRDWRLQTLNGSHAYLTLALHWVEP---REHIIPVVVSHNA 750
+GP ++++ + L TLN + +A P E I+P+ V + A
Sbjct: 2129 IGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKA 2178
Score = 107 bits (268), Expect = 3e-23
Identities = 148/575 (25%), Positives = 241/575 (41%), Gaps = 49/575 (8%)
Query: 69 FAMDPDSGFLLVTRA-LDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFS 127
F + SG L T DRE+Q + + V + + V V V+D+ND P F
Sbjct: 2023 FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFV 2082
Query: 128 QAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLG 187
Y A + T G ++ A DRD N ++ +++ + + FQ+ P LG
Sbjct: 2083 NLPYYAVVKVDTEVGHVIRYVTAVDRDSG--RNGEVHYYL------KEHHEHFQIGP-LG 2133
Query: 188 ALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVS-----IIESTWVSLE 242
++L K LD L + Y + V KD G+ A + + V + E + S E
Sbjct: 2134 EISL--KKQFELD-TLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAE 2190
Query: 243 PIHLAENLKVLYPHHMAQVHWSGG-DVHYHL-ESHPPGPFEVNAE-GNLYVTRELDREAQ 299
+AE+++V P Q + G V Y + + P F +N G + V LD EA
Sbjct: 2191 ---IAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAH 2247
Query: 300 AEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLS 359
Y L +RA +S +A + ++V D NDN P+ + V++ E S GT V ++
Sbjct: 2248 PAYKLSIRATDSLTGAHAEVF-VDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVR 2306
Query: 360 AEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVT-LGVLPLRAGQNILLLVL 418
A D+D+ PN + YQ+ + F VD ++G ++ L L + + V
Sbjct: 2307 ATDSDS--EPNRGISYQMFGNHSKSHDH---FHVDSSTGLISLLRTLDYEQSRQHTIFVR 2361
Query: 419 AMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD 478
A+D G SS V V VTD+ND+ P F QI + E G V + A DAD
Sbjct: 2362 AVD--GGMPTLSSDVIVTVDVTDLNDNPPLF-EQQIYEARISEHAPHGHFVTCVKAYDAD 2418
Query: 479 LEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKL 538
+L ++I G+ F +D +G + L NL A + S+
Sbjct: 2419 SSDIDKL-QYSILSGNDHKHFVID--SATGIITL---SNLHRHA------LKPFYSLNLS 2466
Query: 539 VGPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSD---PISRT 595
V G +T ++ + P Q YE + +AP + ++ ++ +D I
Sbjct: 2467 VSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH 2526
Query: 596 LRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGD 630
+ + +VND G++ T + L P +
Sbjct: 2527 VTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAE 2561
Score = 100 bits (249), Expect = 6e-21
Identities = 156/673 (23%), Positives = 282/673 (41%), Gaps = 86/673 (12%)
Query: 27 VEVPENYG-GNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALD 85
++V EN G+ +++ L G G++V + G + F +D ++G L + LD
Sbjct: 724 IQVKENQPVGSSVIFMNSTDLDT-GFNGKLVYAVSGGNE-DSCFMIDMETGMLKILSPLD 781
Query: 86 REEQAEYQLQVTLEMQDGHVLWGPQPV---LVHVK--DENDQVPHFSQAIYRARLSRGTR 140
RE +Y L +T+ + L PQ L+HV D ND P F Q Y +S
Sbjct: 782 RETTDKYTLNITV-----YDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKE 836
Query: 141 PGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLD 200
+ +EA+D+D N + + I++ D F ++ G + + + LD
Sbjct: 837 VHSEIIQVEATDKDL--GPNGHVTYSIVTDT------DTFSIDSVTGVVNI----ARPLD 884
Query: 201 HALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQ 260
L+ + L ++ +D + +T V+VS+ + P + N +V + +
Sbjct: 885 RELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVN--DNPPTFIPPNYRVKVREDLPE 942
Query: 261 ---VHW---------SGGDVHYHLESHPPGPFEVN-AEGNLYVTRELDREAQAEYLLQVR 307
+ W G V Y L H G F+V+ G + + ++LD E + Y L VR
Sbjct: 943 GTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVR 1002
Query: 308 AQNSHGEDYAAP----LELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDA 363
A++ G+ + +E+ V+ ++EN + P+ ++ E +P G+ V +SA D
Sbjct: 1003 AKDK-GKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDE 1061
Query: 364 DAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLVLAMDL 422
DA + + Y + DG F++ +G + T L + + L V A D
Sbjct: 1062 DA--RRDGEIRYSI-----RDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQ 1114
Query: 423 AGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVE---PGTLVAMLTAIDADL 479
SS E+ + V D+ND+AP+ TS+ P+ PE +E V + A D D
Sbjct: 1115 GVVP--LSSFIEIYIEVEDVNDNAPQ--TSE--PVYYPEIMENSPKDVSVVQIEAFDPDS 1168
Query: 480 EPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLV 539
+LM + I G+ +G F + P +G + + L E H + V V
Sbjct: 1169 SSNDKLM-YKITSGNPQGFFSI--HPKTGLI-TTTSRKLDREQQDEHILEVTVTD----N 1220
Query: 540 GPGPGPGATATVTVLVERVMPPPKLDQESYEASVP-----------ISAPAGSFLLTIQP 588
G P + +++ P+ Q+ Y+ +P P + T +
Sbjct: 1221 GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKD 1280
Query: 589 SDPISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLS 647
P + + +S+ + +E G IE +G V S + + G+ + ++A D P+ S
Sbjct: 1281 EGP-NAEISYSIEDGNEHGKFFIEPKTGVV---SSKRFSAAGEYDILSIKAVDNGRPQKS 1336
Query: 648 ASAPLVIHFLKAP 660
++ L I ++ P
Sbjct: 1337 STTRLHIEWISKP 1349
Score = 98.6 bits (244), Expect = 2e-20
Identities = 157/678 (23%), Positives = 271/678 (39%), Gaps = 60/678 (8%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQ 128
F +D +G + + R LD E+ ++ + V L V V V D ND P F Q
Sbjct: 2333 FHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQ 2392
Query: 129 AIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGA 188
IY AR+S G ++A D D L++ ILS + F ++ G
Sbjct: 2393 QIYEARISEHAPHGHFVTCVKAYDADSSDI--DKLQYSILSGNDHKH----FVIDSATGI 2446
Query: 189 LALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLE-PIHLA 247
+ LS HAL+ Y L + V D ++S + ++ ++ E + LA
Sbjct: 2447 ITLSNLHR----HALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELA 2502
Query: 248 ENLKVLYPHH--MAQVHWSGGD------VHYHL-ESHPPGPFEVNAEGNLYVTRELDREA 298
EN P H + +V + GD V YH+ F +N G ++ +LDRE
Sbjct: 2503 ENA----PLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRET 2558
Query: 299 QAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRL 358
AE ++ VR A ++V++ D+NDN P V+I + GT V ++
Sbjct: 2559 PAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKV 2618
Query: 359 SAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVL 418
A DAD N+ + Y + E + +++ SG +T L +N
Sbjct: 2619 LASDADE--GSNADITYAI---EADSESVKENLEINKLSGVITTKE-SLIGLENEFFTFF 2672
Query: 419 AMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD 478
+ S V V + P+F + ++ EDV GT + ++ A
Sbjct: 2673 VRAVDNGSPSKESVVLVYVKILPPEMQLPKF-SEPFYTFTVSEDVPIGTEIDLIRA---- 2727
Query: 479 LEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKL 538
E + ++ ++ E + D RL+L K+L +E ++ + +A+
Sbjct: 2728 -EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI----LARC 2782
Query: 539 VGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQPSDPISRT-- 595
A+ V++ V+ P + YEA + + P GS ++ I+ SD S T
Sbjct: 2783 TQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNG 2842
Query: 596 -LRFSLVNDSEGWLCIEKF-----SGEVHTAQSLQGAQPGDTYTVLVEAQDTDEP-RLSA 648
+ +SL + S+ IE F +G + T + L + D Y + V A D E +LS+
Sbjct: 2843 QVMYSL-DQSQSVEVIESFAINMETGWITTLKELD-HEKRDNYQIKVVASDHGEKIQLSS 2900
Query: 649 SAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYS-FTLG 707
+A + + +P A + + G+I + D D + + F G
Sbjct: 2901 TAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG 2960
Query: 708 PNP-------TVQRDWRL 718
+P T+Q +W++
Sbjct: 2961 GDPLGQFAVETIQNEWKV 2978
Score = 97.4 bits (241), Expect = 5e-20
Identities = 129/488 (26%), Positives = 203/488 (41%), Gaps = 38/488 (7%)
Query: 286 GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSI 345
G L + LDRE +Y L + + AA LHV+V+D NDN P V +
Sbjct: 772 GMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEV 831
Query: 346 PELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLG-V 404
E +E+ ++ A D D PN HV Y +++ + F +D +G V +
Sbjct: 832 SEDKEVHSEIIQVEATDKDL--GPNGHVTYSIVT-------DTDTFSIDSVTGVVNIARP 882
Query: 405 LPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVE 464
L L + A D A E ST V+V++ D+ND+ P FI + + ED+
Sbjct: 883 LDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNY-RVKVREDLP 941
Query: 465 PGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAP 524
GT++ L A D DL + ++ ++ G EG F +D SG V R+ + L +E
Sbjct: 942 EGTVIMWLEAHDPDLGQSGQVRYSLLDHG--EGNFDVD--KLSGAV--RIVQQLDFEKKQ 995
Query: 525 SHEVVVVVQSVAKLVGPGPGPGATATVTVLVERV-----MPPPKLDQESYEASVPISAPA 579
+ + V + K V ++T V VE V + PP + +V AP
Sbjct: 996 VYNLTVRAKDKGKPV------SLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPV 1049
Query: 580 GSFLLTIQPSDPISR---TLRFSLVNDS-EGWLCIEKFSGEVHTAQSLQGAQPGDTYTVL 635
GS ++T+ D +R +R+S+ + S G I + +G + T+ L + Y +
Sbjct: 1050 GSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLD-RESTSHYWLT 1108
Query: 636 VEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDL 695
V A D LS+ + I T PV + +V + DPD
Sbjct: 1109 VFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDS 1168
Query: 696 ASGHG-PYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVSHN-AQMW 753
+S Y T G NP Q + + G + L + EHI+ V V+ N +
Sbjct: 1169 SSNDKLMYKITSG-NP--QGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPK 1225
Query: 754 QLLVRVIV 761
+ RVIV
Sbjct: 1226 STIARVIV 1233
Score = 89.7 bits (221), Expect = 1e-17
Identities = 106/431 (24%), Positives = 181/431 (41%), Gaps = 38/431 (8%)
Query: 64 ATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQD-GHVLWGPQPVLVHVKDENDQ 122
+ +G F+++ SG + + + LDRE QA Y L + Q L V+V V D ND
Sbjct: 3167 SADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDN 3226
Query: 123 VPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQL 182
P F Y A +S G L + A+ RD AN+++ + I+S F +
Sbjct: 3227 PPVFEYREYGATVSEDILVGTEVLQVYAASRDIE--ANAEITYSIISGN----EHGKFSI 3280
Query: 183 EPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIES------ 236
+ + GA+ + +LD+ Y L V+ D G + AT V V+ I
Sbjct: 3281 DSKTGAVFIIE----NLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336
Query: 237 ----TWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHL-ESHPPGPFEVN-AEGNLYV 290
T V E L +++ + S +HY + + + F ++ G + V
Sbjct: 3337 QDTYTTVISEDAVLEQSVITVMADDADGP--SNSHIHYSIIDGNQGSSFTIDPVRGEVKV 3394
Query: 291 TRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSP 350
T+ LDRE + Y L V+A ++ +++ V D NDN P+ + +V I E P
Sbjct: 3395 TKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKP 3454
Query: 351 PGTEVTRLSAEDADAP--GSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLR 408
G V +L D D+ G P + G + +AF+V+P +T + +
Sbjct: 3455 VGFSVLQLVVTDEDSSHNGPPFFFTIV--------TGNDEKAFEVNPQGVLLTSSAIKRK 3506
Query: 409 AGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTL 468
+ LL V D + SS +++ V + + + P + +I S E+ G +
Sbjct: 3507 EKDHYLLQVKVAD--NGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYS-GGV 3563
Query: 469 VAMLTAIDADL 479
+ + A D D+
Sbjct: 3564 IGKIHATDQDV 3574
Score = 82.0 bits (201), Expect = 2e-15
Identities = 152/666 (22%), Positives = 260/666 (39%), Gaps = 85/666 (12%)
Query: 18 PKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSG-DSGKATEGPFAMDPDSG 76
P P V+V E+ + + P G GQ+ S D G EG F +D SG
Sbjct: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHG---EGNFDVDKLSG 981
Query: 77 FLLVTRALDREEQAEYQLQVTLEMQDGHV-LWGPQPVLVHVKDENDQV--PHFSQAIYRA 133
+ + + LD E++ Y L V + + V L V V V D N+ + P FS + +
Sbjct: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
Query: 134 RLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSP 193
+ G L + S DE + ++R+ I + +F++ G + S
Sbjct: 1042 TVKEDAPVGS--LVMTVSAHDEDARRDGEIRYSIRDGSGV----GVFKIGEETGVIETSD 1095
Query: 194 KGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSII-ESTWVSLEPIHLAE---- 248
+ LD Y L V D G +EV + ++ + EP++ E
Sbjct: 1096 R----LDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMEN 1151
Query: 249 ---NLKVLYPHHMAQVHWSGGDVHYHLES-HPPGPFEVNAEGNLYVT--RELDREAQAEY 302
++ V+ S + Y + S +P G F ++ + L T R+LDRE Q E+
Sbjct: 1152 SPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEH 1211
Query: 303 LLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTE-------V 355
+L+V ++ + + V ++DENDN P + + +PE P E +
Sbjct: 1212 ILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPL 1271
Query: 356 TRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILL 415
+ A D D PN+ + Y + EDG E F ++P +G V+ AG+ +L
Sbjct: 1272 YHVIATDKDE--GPNAEISYSI-----EDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDIL 1323
Query: 416 LVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPED------VEPGTLV 469
+ A+D + ++ +E I+ P + PIS E +E +
Sbjct: 1324 SIKAVDNGRPQKSSTTRLHIEW----ISKPKP-----SLEPISFEESFFTFTVMESDPVA 1374
Query: 470 AMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVV 529
M+ I +EP + F I T G + ++ D G + + K L E ++ +
Sbjct: 1375 HMIGVI--SVEPPGIPLWFDI----TGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLT 1428
Query: 530 VVVQSVAKLVGPGPGPGATATVTVLVERVMPP----PKLDQESYEASVPISAPAGSFLLT 585
V G T +T + +V+ P+ YE +P + +L
Sbjct: 1429 VEATD-----------GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQ 1477
Query: 586 IQPSDPISRTLRFSLVNDSEGWLCIEKF-----SGEVHTAQSL-QGAQPGDTYTVLVEAQ 639
I D + + S L ++KF +G ++T++ L A T TV+V Q
Sbjct: 1478 ISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQ 1537
Query: 640 DTDEPR 645
D R
Sbjct: 1538 DVPVKR 1543
Score = 62.4 bits (150), Expect = 2e-09
Identities = 119/518 (22%), Positives = 196/518 (37%), Gaps = 59/518 (11%)
Query: 18 PKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGF 77
P P SV +PEN + G G+ S K FA+ P SG
Sbjct: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF---KDRTDMFAIHPTSGV 203
Query: 78 LLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPV------LVHVKDENDQVPHFSQAIY 131
+++T LD E Y++++ L G L+G + VH++ N+ P I
Sbjct: 204 IVLTGRLDYLETKLYEMEI-LAADRGMKLYGSSGISSMAKLTVHIEQANECAP----VIT 258
Query: 132 RARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALAL 191
LS P + D + G AN D+ LS + G+
Sbjct: 259 AVTLSPSELDRDPAYAIVTVDDCDQG-ANGDIAS--LSIVAGDLLQQFRTVRSFPGSKEY 315
Query: 192 SPKGSTSLD-HALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPI------ 244
K +D + Y L +Q KD G ++V+V + S P+
Sbjct: 316 KVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQ----FSSVKVIHVTSPQFKAGPVKFEKDV 371
Query: 245 ---HLAENLKVLYPHHMAQVHWSGGDVHYHLESHP-PGPFEVNAE-GNLYVTRELDREAQ 299
++E P M + + + Y +S P F +N G + + + R+
Sbjct: 372 YRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQA 431
Query: 300 AEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLS 359
A + L+V D A ++ V V+ N N P + E P GT V LS
Sbjct: 432 AHFELEVTTS-----DRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLS 486
Query: 360 AEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLA 419
A D D N +V Y + + + F +D +G+V+ ++ V
Sbjct: 487 AVDPDE--GENGYVTYSIAN------LNHVPFAIDHFTGAVSTSE---NLDYELMPRVYT 535
Query: 420 MDLAGAEGGFSSTCEVEVAVT----DINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAI 475
+ + ++ G EVEV T ++ND+ P F ++P D+ G + ++AI
Sbjct: 536 LRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEG-TIPRDLGVGEQITTVSAI 594
Query: 476 DADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLR 513
DAD +L+ + IE G+ F L+ P+SG + L+
Sbjct: 595 DAD---ELQLVQYQIEAGNELDFFSLN--PNSGVLSLK 627
Score = 57.8 bits (138), Expect = 4e-08
Identities = 76/304 (25%), Positives = 127/304 (41%), Gaps = 25/304 (8%)
Query: 291 TRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSP 350
T L+RE + Y L V+A + + A ++ V V+D ND P+ P +VS+PE +
Sbjct: 105 TAILNREVKDHYTLIVKALEKN-TNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTA 163
Query: 351 PGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTL-GVLPLRA 409
T + R+SA DAD N Y +D + F + PTSG + L G L
Sbjct: 164 IRTSIARVSATDADI--GTNGEFYYSF-----KDRTD--MFAIHPTSGVIVLTGRLDYLE 214
Query: 410 GQNILLLVLAMD----LAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEP 465
+ + +LA D L G+ G SS ++ V + N+ AP + P L D
Sbjct: 215 TKLYEMEILAADRGMKLYGS-SGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD--- 270
Query: 466 GTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTF-GLDWEPDSGHVRLRLCKNLSYEAAP 524
A++T D D + +I GD F + P S +++ + ++
Sbjct: 271 -PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWD--- 326
Query: 525 SHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFL 583
SH + AK G P + + V + P K +++ Y A + AP + +
Sbjct: 327 SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386
Query: 584 LTIQ 587
+ ++
Sbjct: 387 VMVK 390
Score = 56.6 bits (135), Expect = 9e-08
Identities = 142/648 (21%), Positives = 248/648 (38%), Gaps = 119/648 (18%)
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F + +YRA +S P P + ++A A S LR+ S P F L
Sbjct: 367 FEKDVYRAEISEFAPPNTPVVMVKAIP------AYSHLRYVFKST----PGKAKFSLNYN 416
Query: 186 LGALA-LSPKGSTSLDH------ALERTYQLLVQVKDMGDQASGHQATATV------EVS 232
G ++ L P H +R V VK +G ++ + T T E
Sbjct: 417 TGLISILEPVKRQQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENV 476
Query: 233 IIESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNA-EGNLYVT 291
I +T +SL + E G V Y + + PF ++ G + +
Sbjct: 477 PIGTTVMSLSAVDPDEG--------------ENGYVTYSIANLNHVPFAIDHFTGAVSTS 522
Query: 292 RELDREAQAE-YLLQVRAQNSHGEDYAAPLEL--HVLVMDENDNVPICPPRDPTVSIPEL 348
LD E Y L++RA + G Y +E+ + + + NDN P+ + +IP
Sbjct: 523 ENLDYELMPRVYTLRIRASD-WGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRD 581
Query: 349 SPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLG----- 403
G ++T +SA DAD QL+ + E G E F ++P SG ++L
Sbjct: 582 LGVGEQITTVSAIDADE---------LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMD 632
Query: 404 ---------------------VLPLRAGQNILLLVLAMDLAGAEGGFSSTC--------- 433
PL + ++L E G +
Sbjct: 633 GLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANK 692
Query: 434 -----EVEVAVTD---INDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRL 485
EVE D +N H P+F ++ I + E+ G+ V + + D D +L
Sbjct: 693 LHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKL 752
Query: 486 MDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGP 545
+ +A+ G+ + F +D E L++ L E + + + V + P
Sbjct: 753 V-YAVSGGNEDSCFMIDMETG----MLKILSPLDRETTDKYTLNITVYDLGI-----PQK 802
Query: 546 GATATV-TVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLV 601
A + V+V+ PP+ QESY V S ++ ++ +D + + +S+V
Sbjct: 803 AAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV 862
Query: 602 NDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQD--TDEPRLSASAPLVIHFLKA 659
D++ + I+ +G V+ A+ L + +++ +EA+D +EP+L ++ + +
Sbjct: 863 TDTDTF-SIDSVTGVVNIARPLD-RELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDV 920
Query: 660 PPAPALTLAPVPSQYLCTPRQD--HGLIVSG-PSKDPDLA-SGHGPYS 703
P +P Y R+D G ++ + DPDL SG YS
Sbjct: 921 NDNPPTF---IPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYS 965
Score = 39.3 bits (90), Expect = 0.015
Identities = 44/219 (20%), Positives = 90/219 (41%), Gaps = 33/219 (15%)
Query: 438 AVTDINDHAPEFITSQIGPISLPEDV---------EPGTLVAMLTAIDADLEPAFRLMDF 488
+V I+ +P+F + GP+ +DV P T V M+ AI PA+ + +
Sbjct: 349 SVKVIHVTSPQF---KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAI-----PAYSHLRY 400
Query: 489 AIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGAT 548
+ + F L++ + + + + + A E+ V +T
Sbjct: 401 VFKSTPGKAKFSLNYNTGL----ISILEPVKRQQAAHFELEVTTSD---------RKAST 447
Query: 549 ATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRT---LRFSLVNDSE 605
+ ++ PP+ Q +Y+A+ + P G+ ++++ DP + +S+ N +
Sbjct: 448 KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNH 507
Query: 606 GWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEP 644
I+ F+G V T+++L YT+ + A D P
Sbjct: 508 VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546
Score = 38.9 bits (89), Expect = 0.020
Identities = 104/456 (22%), Positives = 180/456 (39%), Gaps = 71/456 (15%)
Query: 56 VLSGDSGKATEGPFAMDPDSGFLLV------TRALDREEQAEYQLQVTLEMQDGHVLWGP 109
++SGDS + + D FL + T L+RE + Y L V ++ +V
Sbjct: 74 IVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVE-AR 132
Query: 110 QPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILS 169
V V V D ND P FS Y L T + A+D D GT N + +
Sbjct: 133 TKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDAD-IGT-NGEFYYSFKD 190
Query: 170 QAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQ---ASGHQAT 226
+ DMF + P G + L+ + LD+ + Y++ + D G + +SG +
Sbjct: 191 RT------DMFAIHPTSGVIVLTGR----LDYLETKLYEMEILAADRGMKLYGSSGISSM 240
Query: 227 ATVEVSIIES-------TWVSLEPIHL----------AENLKVLYPHHMAQVHWSGGDV- 268
A + V I ++ T V+L P L ++ +A + GD+
Sbjct: 241 AKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLL 300
Query: 269 -HYHLESHPPG--PFEVNAEGNLYVTRELDREAQA-EYLLQVRAQNSHGEDYAAPLELHV 324
+ PG ++V A G +D ++ Y L ++A++ + +++
Sbjct: 301 QQFRTVRSFPGSKEYKVKAIGG------IDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIH 354
Query: 325 LVMDENDNVPICPPRDP-TVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPE 383
+ + P+ +D I E +PP T V + A A SH+ Y S
Sbjct: 355 VTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA------YSHLRYVFKS---- 404
Query: 384 DGVEGRA-FQVDPTSGSVTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDI 442
G+A F ++ +G +++ + P++ Q +L ++ +V V V
Sbjct: 405 --TPGKAKFSLNYNTGLISI-LEPVKRQQ-----AAHFELEVTTSDRKASTKVLVKVLGA 456
Query: 443 NDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD 478
N + PEF T + E+V GT V L+A+D D
Sbjct: 457 NSNPPEF-TQTAYKAAFDENVPIGTTVMSLSAVDPD 491
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 139 bits (351), Expect = 8e-33
Identities = 149/574 (25%), Positives = 250/574 (43%), Gaps = 38/574 (6%)
Query: 266 GDVHYHLESHPPGPFEVNAE--GNLYVTRELDREAQAEYLLQVRAQNSH-GEDYAAPLEL 322
G + Y L G + E G++ T+ LDRE + Y+L+ +A N G E
Sbjct: 86 GSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEF 145
Query: 323 HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPE 381
+ + D NDN PI T ++PE+S GT V +++A DAD P NS VVY +L +
Sbjct: 146 IIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQ 205
Query: 382 PEDGVEGRAFQVDPTSGSVTLGVLPL--RAGQNILLLVLAMDLAGAEGGFSSTCEVEVAV 439
P F V+ +G + +L + + +++ A D+ G GG S T V + +
Sbjct: 206 P-------YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITL 258
Query: 440 TDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTF 499
TD+ND+ P F S PE PGT + + A DAD+ + +++I G+ F
Sbjct: 259 TDVNDNPPRFPQSTY-QFKTPESSPPGTPIGRIKASDADVGENAEI-EYSITDGEGLDMF 316
Query: 500 GLDWEPDSGHVRLRLCKNLSYEAAPSHEVVV-----VVQSVAKLVGPGPGPGATATVTVL 554
+ + ++ + + K L +E + + V V+ +GP +ATV ++
Sbjct: 317 DVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKD---SATVRIV 373
Query: 555 VERVMPPPKLDQESYEASVPISAPAGSFL--LTIQPSDPISRTLRFSL--VNDSEGWLCI 610
VE V PP + +Y + A + + +T Q D +++S+ D + I
Sbjct: 374 VEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNI 433
Query: 611 EKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPV 670
+ +G + T++ L + + + V A + + P+ S+ PL I L A A
Sbjct: 434 DSGNGSIFTSKLLD-RETLLWHNITVIATEINNPKQSSRVPLYIKVLDVND-NAPEFAEF 491
Query: 671 PSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTL 730
++C + LI + + D D +SF+L P ++ +Q + A +
Sbjct: 492 YETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILT 551
Query: 731 ALHWVEPRE---HIIPVVVSHN---AQMWQLLVRVIVCRCNVEGQCMRKVGRMKGMPTKL 784
+ E +++PVV+S N Q V V VC C+ G PT L
Sbjct: 552 RKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGL 611
Query: 785 SAVGILVGTLVAIGIFL--ILIFTHWTMSRKKDP 816
S G LV L+ I I L +++F RKK+P
Sbjct: 612 S-TGALVAILLCIVILLVTVVLFAALRRQRKKEP 644
Score = 96.7 bits (239), Expect = 8e-20
Identities = 118/480 (24%), Positives = 210/480 (43%), Gaps = 60/480 (12%)
Query: 31 ENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDREE 88
E Y G+ Y+ KL ++ +G + +LSGD F ++ ++G + T+ LDREE
Sbjct: 64 EEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDL---FIINENTGDIQATKRLDREE 120
Query: 89 QAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLF 147
+ Y L+ + + G + ++ + D ND P F++ +Y A + + G +
Sbjct: 121 KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ 180
Query: 148 LEASDRDEPGTANS-DLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERT 206
+ A+D D+P NS + + IL P F +E G + + ++D
Sbjct: 181 VTATDADDPTYGNSAKVVYSILQGQP------YFSVESETGIIKTA---LLNMDRENREQ 231
Query: 207 YQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHH-------MA 259
YQ+++Q KDMG Q G T TV +++ T V+ P ++ +
Sbjct: 232 YQVVIQAKDMGGQMGGLSGTTTVNITL---TDVNDNPPRFPQSTYQFKTPESSPPGTPIG 288
Query: 260 QVHWSGGDVHYHLE---SHPPGP----FEV-----NAEGNLYVTRELDREAQAEYLLQVR 307
++ S DV + E S G F+V EG + V + LD E + Y L+V
Sbjct: 289 RIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVE 348
Query: 308 AQNSHGED---YAAPLELHV---LVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAE 361
A N + E Y P + +V+++ D P+ + I E + T + ++A+
Sbjct: 349 ASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQ 408
Query: 362 DADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNIL---LLVL 418
D DA +P + V + + R F +D +GS+ L R + +L + V+
Sbjct: 409 DPDAARNPVKYSVDRHTDMD-------RIFNIDSGNGSIFTSKLLDR--ETLLWHNITVI 459
Query: 419 AMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD 478
A ++ + SS + + V D+ND+APEF ++ + E + L+ L A+D D
Sbjct: 460 ATEINNPKQ--SSRVPLYIKVLDVNDNAPEF--AEFYETFVCEKAKADQLIQTLHAVDKD 515
Score = 62.4 bits (150), Expect = 2e-09
Identities = 102/458 (22%), Positives = 182/458 (39%), Gaps = 52/458 (11%)
Query: 47 PREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRA-LDREEQAEYQLQVTLEMQDGHV 105
P G ++V S G+ F+++ ++G + +DRE + +YQ+ + + G +
Sbjct: 189 PTYGNSAKVVYSILQGQPY---FSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQM 245
Query: 106 --LWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDL 163
L G V + + D ND P F Q+ Y+ + + PG P ++ASD D N+++
Sbjct: 246 GGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADV--GENAEI 303
Query: 164 RFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQ-----VKDMGD 218
+ I + E + G + + LD ++ Y L V+ V+
Sbjct: 304 EYSITDGEGLDMFDVITDQETQEGIITV----KKLLDFEKKKVYTLKVEASNPYVEPRFL 359
Query: 219 QASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGD----------- 267
+ +ATV + + + EP ++ +L AQ++ + G
Sbjct: 360 YLGPFKDSATVRIVVEDVD----EPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN 415
Query: 268 -VHYHLESHPPGP--FEVNA-EGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELH 323
V Y ++ H F +++ G+++ ++ LDRE + + V A + ++ + L+
Sbjct: 416 PVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLY 475
Query: 324 VLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPE 383
+ V+D NDN P T + E + + L A D D P S H L+PE
Sbjct: 476 IKVLDVNDNAPEFAEFYETF-VCEKAKADQLIQTLHAVDKDDPYS--GHQFSFSLAPE-- 530
Query: 384 DGVEGRAFQVDPTSGSVTLGVLPLRAGQN------ILLLVLAMDLAGAEGGFSSTCEVEV 437
G F + + T G+L + G N LL V+ D + T V V
Sbjct: 531 -AASGSNFTIQDNKDN-TAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
Query: 438 AVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAI 475
DH + + P + G LVA+L I
Sbjct: 589 CAC---DHHGNMQSCHAEALIHPTGLSTGALVAILLCI 623
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 137 bits (346), Expect = 3e-32
Identities = 166/655 (25%), Positives = 266/655 (40%), Gaps = 48/655 (7%)
Query: 18 PKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDS--GKATEGPFAMDPDS 75
P+ QP VPEN P+ + P EG G++ + D+ + F++DP +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 76 GFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARL 135
G + LDRE ++ + +VT + + + V D ND P F Q Y+ L
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
Query: 136 SRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKG 195
G L + A+D D P AN + + +L + PS ++F+++PR G + +
Sbjct: 299 RENLEVGYEVLTVRATDGDAPPNAN--ILYRLLEGSGGSPS-EVFEIDPRSGVI----RT 351
Query: 196 STSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSI----------IESTWVSLEPIH 245
+D +YQL V+ D G TA V +S+ E +V
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 411
Query: 246 LAENLKVLYPHHMAQVHWSGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYL 303
+ VL + S VHY + S + G F ++A+ G L V LD E EY
Sbjct: 412 VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYT 471
Query: 304 LQVRAQNSHGEDYAAPLEL-HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAED 362
L+VRAQ+ + L V V+D NDN PI ++ E P G V + A D
Sbjct: 472 LRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAID 531
Query: 363 ADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAMDL 422
ADA N+ + Y+L GV G F +G+ + V + + ++
Sbjct: 532 ADA--GDNARLEYRLA------GV-GHDFPFTINNGTGWISVAAELDREEVDFYSFGVEA 582
Query: 423 AG-AEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEP 481
+++ V V V D+ND+ P F T + L ED GT V ++A+D D
Sbjct: 583 RDHGTPALTASASVSVTVLDVNDNNPTF-TQPEYTVRLNEDAAVGTSVVTVSAVDRD--- 638
Query: 482 AFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGP 541
A ++ + I G+T F + + G V L L L Y+ + + V
Sbjct: 639 AHSVITYQITSGNTRNRFSITSQSGGGLVSLAL--PLDYKLERQYVLAVTASD------- 689
Query: 542 GPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSD-PISRTLRFS- 599
G V + + P Y +V PAG+ ++ I +D R +
Sbjct: 690 GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749
Query: 600 LVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVI 654
+ DS I+ +G V T Q+ + +YT+ + A+D P+ S + L I
Sbjct: 750 FMEDSIPQFRIDADTGAV-TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEI 803
Score = 137 bits (346), Expect = 3e-32
Identities = 170/594 (28%), Positives = 260/594 (43%), Gaps = 68/594 (11%)
Query: 56 VLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQP---- 111
+L G G +E F +DP SG + +DREE YQL T+E D GP+
Sbjct: 328 LLEGSGGSPSE-VFEIDPRSGVIRTRGPVDREEVESYQL--TVEASDQGRDPGPRSTTAA 384
Query: 112 VLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQA 171
V + V+D+ND P FS+ Y ++ PG P L + ASDRD+ +N+ + + I+S
Sbjct: 385 VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDK--GSNAVVHYSIMS-- 440
Query: 172 PAQPSPDMFQLEPRLGAL-ALSPKGSTSLDHALERTYQLLVQVKDMG----DQASGHQAT 226
+ F L+ + GAL +SP LD+ + Y L V+ +D G SG
Sbjct: 441 --GNARGQFYLDAQTGALDVVSP-----LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTV 493
Query: 227 ATVEVSIIESTWVSLE-PIHLAENLKVLY-PHHMAQVHWSGGDVHYHLESHPPG-----P 279
++++ +VS + E++ + Y H+ + GD + LE G P
Sbjct: 494 QVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD-NARLEYRLAGVGHDFP 552
Query: 280 FEV-NAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPP 338
F + N G + V ELDRE Y V A++ A + V V+D NDN P
Sbjct: 553 FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ 612
Query: 339 RDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSG 398
+ TV + E + GT V +SA D DA +S + YQ+ S G F + SG
Sbjct: 613 PEYTVRLNEDAAVGTSVVTVSAVDRDA----HSVITYQITS-----GNTRNRFSITSQSG 663
Query: 399 SVTLGV-LPL--RAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIG 455
+ + LPL + + +L V A D G T ++ V VTD N H P F +S
Sbjct: 664 GGLVSLALPLDYKLERQYVLAVTASD-----GTRQDTAQIVVNVTDANTHRPVFQSSHY- 717
Query: 456 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLC 515
+++ ED GT V +++A D D R+ F D+ F +D D+G V +
Sbjct: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYF---MEDSIPQFRID--ADTGAVTTQ-- 770
Query: 516 KNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVP 574
L YE S+ + + + P T + +LV V P+ ++SY+ SV
Sbjct: 771 AELDYEDQVSYTLAITARD-----NGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
Query: 575 ISAPAGSFLLTIQPSDPISRT-----LRFSLVNDSEGWLCIEKFSGEVHTAQSL 623
P + +L I +D S F +D +G +E SG V T + L
Sbjct: 826 EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
Score = 116 bits (291), Expect = 7e-26
Identities = 164/587 (27%), Positives = 241/587 (41%), Gaps = 57/587 (9%)
Query: 61 SGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEN 120
+G + PF ++ +G++ V LDREE Y V L V V V D N
Sbjct: 545 AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVN 604
Query: 121 DQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMF 180
D P F+Q Y RL+ G + + A DRD A+S + + I S
Sbjct: 605 DNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD----AHSVITYQITSGNTRNRFSITS 660
Query: 181 QLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTW-- 238
Q L +LAL LD+ LER Y L V D Q TA + V++ ++
Sbjct: 661 QSGGGLVSLAL------PLDYKLERQYVLAVTASD-----GTRQDTAQIVVNVTDANTHR 709
Query: 239 VSLEPIHLAENLKVLYPHHMAQVHWSGGD--------VHYHLESHPPGPFEVNAEGNLYV 290
+ H N+ P V S D + Y +E P F ++A+
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDADTGAVT 768
Query: 291 TR-ELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELS 349
T+ ELD E Q Y L + A+++ + L +LV D NDN P S+ E
Sbjct: 769 TQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDV 828
Query: 350 PPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLR 408
PP T V ++SA D D+ N V Y + DG F V+ TSG V TL L
Sbjct: 829 PPFTSVLQISATDRDS--GLNGRVFYTFQGGDDGDG----DFIVESTSGIVRTLRRLDRE 882
Query: 409 AGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTL 468
+L A+D + EV V V D+ND+ P F + + + E+ G
Sbjct: 883 NVAQYVLRAYAVDKGMPPA--RTPMEVTVTVLDVNDNPPVFEQDEF-DVFVEENSPIGLA 939
Query: 469 VAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEV 528
VA +TA D D ++M + I G+ F LD SG L +L YE P + V
Sbjct: 940 VARVTATDPDEGTNAQIM-YQIVEGNIPEVFQLD--IFSG--ELTALVDLDYEDRPEY-V 993
Query: 529 VVVVQSVAKLVGPGPGPGATATVTV-LVERVMPPPKLDQ-----ESYEASVPISAPAGSF 582
+V+ + A LV + ATV V L++R PP L +Y + S P G+
Sbjct: 994 LVIQATSAPLV-------SRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAI 1046
Query: 583 LLTIQPSDPISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQP 628
IS +L +S +E + + +GE+ +++L +P
Sbjct: 1047 GRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRP 1093
Score = 114 bits (286), Expect = 3e-25
Identities = 125/468 (26%), Positives = 202/468 (43%), Gaps = 24/468 (5%)
Query: 286 GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSI 345
G + ELDRE ++ ++ +V AQ+ +A L +LV D ND+ P+ ++ S+
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESL 298
Query: 346 PELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGV 404
E G EV + A D DAP PN++++Y+LL E G F++DP SG + T G
Sbjct: 299 RENLEVGYEVLTVRATDGDAP--PNANILYRLL--EGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 405 LPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVE 464
+ ++ L V A D G S+T V ++V D ND+AP+F + + + EDV
Sbjct: 355 VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRY-VVQVREDVT 413
Query: 465 PGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAP 524
PG V +TA D D + + ++ ++I G+ G F LD + + L + L YE
Sbjct: 414 PGAPVLRVTASDRD-KGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDYETTK 468
Query: 525 SHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFL 583
+ + V Q G P + VTV V + P ++A+V S P G +
Sbjct: 469 EYTLRVRAQD----GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV 524
Query: 584 LTIQPSDP---ISRTLRFSLVNDSEGW-LCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQ 639
L +Q D + L + L + I +G + A L + D Y+ VEA+
Sbjct: 525 LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELD-REEVDFYSFGVEAR 583
Query: 640 DTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGH 699
D P L+ASA + + L P +Y +D + S + H
Sbjct: 584 DHGTPALTASASVSVTVLDVNDNNPTFTQP---EYTVRLNEDAAVGTSVVTVSAVDRDAH 640
Query: 700 GPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVS 747
++ + T R G L L L + R++++ V S
Sbjct: 641 SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTAS 688
Score = 65.5 bits (158), Expect = 2e-10
Identities = 92/362 (25%), Positives = 141/362 (38%), Gaps = 31/362 (8%)
Query: 331 DNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRA 390
+ P P ++PE P GT V L A D D + L D +
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALF----DSRSNQF 231
Query: 391 FQVDPTSGSVTLG-VLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEF 449
F +DP +G+VT L + V A D S+ + + VTD NDH P F
Sbjct: 232 FSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRR--SALATLTILVTDTNDHDPVF 289
Query: 450 ITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGH 509
Q SL E++E G V + A D D P ++ +E + + +P SG
Sbjct: 290 -EQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
Query: 510 VRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGP-GATATVTVLVERVMP-PPKLDQE 567
+R R + E S+++ V A G PGP TA V + VE P+ ++
Sbjct: 349 IRTR--GPVDREEVESYQLTV----EASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEK 402
Query: 568 SYEASVPISAPAGSFLLTIQPSD---PISRTLRFSLVN-DSEGWLCIEKFSGEVHTAQSL 623
Y V G+ +L + SD + + +S+++ ++ G ++ +G + L
Sbjct: 403 RYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPL 462
Query: 624 QGAQPGDTYTVLVEAQDTDEPRLSASAPLV----------IHFLKAPPAPALTLAPVPSQ 673
+ YT+ V AQD P LS + LV + P A L VP
Sbjct: 463 D-YETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
Query: 674 YL 675
YL
Sbjct: 522 YL 523
Score = 55.5 bits (132), Expect = 2e-07
Identities = 113/493 (22%), Positives = 183/493 (37%), Gaps = 69/493 (13%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQ 128
F +D D+G + LD E+Q Y L +T + + V D ND P F +
Sbjct: 758 FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLR 817
Query: 129 AIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGA 188
Y+ + P L + A+DRD + + R Q D F +E G
Sbjct: 818 DSYQGSVYEDVPPFTSVLQISATDRD----SGLNGRVFYTFQGGDDGDGD-FIVESTSGI 872
Query: 189 LALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAE 248
+ + LD Y L D G + TV V + E
Sbjct: 873 VRTLRR----LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDV 928
Query: 249 NLKVLYPHHMAQVHWSGGD---------VHYHLESHPPGPFEVNA-EGNLYVTRELDREA 298
++ P +A + D ++ +E + P F+++ G L +LD E
Sbjct: 929 FVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYED 988
Query: 299 QAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPT----VSIPELSPPGTE 354
+ EY+L ++A ++ + +HV ++D NDN P+ + V+ S PG
Sbjct: 989 RPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGA 1045
Query: 355 VTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNIL 414
+ R+ A D D S L+ E G E ++ ++G + L RA N
Sbjct: 1046 IGRVPAHDPDISDS---------LTYSFERGNELSLVLLNASTGELKLS----RALDNNR 1092
Query: 415 LLVLAMDLAGAEGGFSSTCEVEVAVTDINDHA-PEFITSQIGPISLPEDVEPGTLVAMLT 473
L M + ++G S T + + VT I D IT ++ +S PE L +
Sbjct: 1093 PLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMS-PERFLSPLLGLFIQ 1151
Query: 474 AIDADLE-PAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVV 532
A+ A L P ++ F ++R DT+ AP ++ V
Sbjct: 1152 AVAATLATPPDHVVVFNVQR-DTD--------------------------APGGHILNVS 1184
Query: 533 QSVAKLVGPGPGP 545
SV + GPG GP
Sbjct: 1185 LSVGQPPGPGGGP 1197
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/163 (26%), Positives = 67/163 (41%), Gaps = 10/163 (6%)
Query: 50 GAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGP 109
G G++ + G +G F ++ SG + R LDRE A+Y L+ + P
Sbjct: 845 GLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTP 904
Query: 110 QPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILS 169
V V V D ND P F Q + + + G+ + A+D DE A I+
Sbjct: 905 MEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNA------QIMY 958
Query: 170 QAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQ 212
Q P++FQL+ G L LD+ Y L++Q
Sbjct: 959 QIVEGNIPEVFQLDIFSGELT----ALVDLDYEDRPEYVLVIQ 997
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 137 bits (346), Expect = 3e-32
Identities = 141/533 (26%), Positives = 229/533 (42%), Gaps = 28/533 (5%)
Query: 286 GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSI 345
GNL+ TR +DRE + L A + G PL L + V DENDN P+ +
Sbjct: 193 GNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEV 252
Query: 346 PELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTL--G 403
E S PGT V + A D D P + ++ + Y +L P F V P++G +T
Sbjct: 253 LESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPR---SPGLFSVHPSTGVITTVSH 309
Query: 404 VLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDV 463
L L++ D+ G G T + VTD ND+AP F Q + E+
Sbjct: 310 YLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTF--RQNAYEAFVEEN 367
Query: 464 EPGTLVAMLTAIDADL-EPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEA 522
+ + D DL A ++F I +G+ G F + + ++ L + K L+YE
Sbjct: 368 AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
Query: 523 APSHEVVVVVQSVAKLVGPGPGPGA--TATVTVLVERVMPPPKLDQESYEASVPISAPAG 580
+ + V + A P A A VTV V + P+ + + + G
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
Query: 581 SFLLTIQPSDPISRT---LRFSLVNDSEGWLCIEKFSGEVHTAQSLQ---GAQPGDTYTV 634
S + + DP +R LR+ ++D +GW+ I++ SG + T++ L + Y +
Sbjct: 488 SKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNI 547
Query: 635 LVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPD 694
V A D D+ + + + I + P L V +C P+ + I+ + DPD
Sbjct: 548 TVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVV----ICKPKMGYTDIL---AVDPD 600
Query: 695 LASGHGPYSFTL-GPNPTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNA-QM 752
P+ F+L +P + R W L +N + A L+ + +E+ IP+ V A Q
Sbjct: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKN-AGFQEYTIPITVKDRAGQA 659
Query: 753 WQLLVRVIVCRCNVEGQCMRKVGRMKGMPT-KLSAVGILVGTLVAIGIFLILI 804
L+RV +C C QC R R G+ K + + IL+G + + L L+
Sbjct: 660 ATKLLRVNLCECTHPTQC-RATSRSTGVILGKWAILAILLGIALLFSVLLTLV 711
Score = 114 bits (284), Expect = 5e-25
Identities = 123/481 (25%), Positives = 211/481 (43%), Gaps = 77/481 (16%)
Query: 19 KAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGP----FAMDPD 74
K + A + + EN G FPL+L ++ + A+ V SG+ + F ++ D
Sbjct: 134 KRRWAPIPCSMQENSLGPFPLFLQQVE--SDAAQNYTVFYSISGRGVDKEPLNLFYIERD 191
Query: 75 SGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRAR 134
+G L TR +DREE + L DG+ P P+ + V+DEND P F++AIY
Sbjct: 192 TGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFE 251
Query: 135 LSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPK 194
+ +RPG + A+DRDEP T ++ L++ IL Q P SP +F + P G +
Sbjct: 252 VLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPR--SPGLFSVHPSTGVI----- 304
Query: 195 GSTSLDHALER----TYQLLVQVKDMGDQASGHQATATVEVSI----------------- 233
T++ H L+R Y L+++V+DM Q G T+T +++
Sbjct: 305 --TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEA 362
Query: 234 -IESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNA-----EGN 287
+E ++E + + K L +V+++ L+ + G F+++ EG
Sbjct: 363 FVEENAFNVEILRIPIEDKDLINTANWRVNFT------ILKGNENGHFKISTDKETNEGV 416
Query: 288 LYVTRELDREAQAEYLLQVRAQNS--HGEDY-------AAPLELHVLVMDENDNVPICPP 338
L V + L+ E + L++ N D A + +HV +DE P C P
Sbjct: 417 LSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEG---PECTP 473
Query: 339 RDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSG 398
V I E G+++ A D P + N + + +P+ + +D SG
Sbjct: 474 AAQYVRIKENLAVGSKINGYKAYD---PENRNGNGLRYKKLHDPKGWI-----TIDEISG 525
Query: 399 SVTLGVL---PLRAGQNIL--LLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQ 453
S+ + + +N L + VLA+D + S T + V + D+ND+ PE +
Sbjct: 526 SIITSKILDREVETPKNELYNITVLAID----KDDRSCTGTLAVNIEDVNDNPPEILQEY 581
Query: 454 I 454
+
Sbjct: 582 V 582
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 137 bits (346), Expect = 3e-32
Identities = 141/533 (26%), Positives = 229/533 (42%), Gaps = 28/533 (5%)
Query: 286 GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSI 345
GNL+ TR +DRE + L A + G PL L + V DENDN P+ +
Sbjct: 193 GNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEV 252
Query: 346 PELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTL--G 403
E S PGT V + A D D P + ++ + Y +L P F V P++G +T
Sbjct: 253 LESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPR---SPGLFSVHPSTGVITTVSH 309
Query: 404 VLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDV 463
L L++ D+ G G T + VTD ND+AP F Q + E+
Sbjct: 310 YLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTF--RQNAYEAFVEEN 367
Query: 464 EPGTLVAMLTAIDADL-EPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEA 522
+ + D DL A ++F I +G+ G F + + ++ L + K L+YE
Sbjct: 368 AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
Query: 523 APSHEVVVVVQSVAKLVGPGPGPGA--TATVTVLVERVMPPPKLDQESYEASVPISAPAG 580
+ + V + A P A A VTV V + P+ + + + G
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
Query: 581 SFLLTIQPSDPISRT---LRFSLVNDSEGWLCIEKFSGEVHTAQSLQ---GAQPGDTYTV 634
S + + DP +R LR+ ++D +GW+ I++ SG + T++ L + Y +
Sbjct: 488 SKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNI 547
Query: 635 LVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPD 694
V A D D+ + + + I + P L V +C P+ + I+ + DPD
Sbjct: 548 TVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVV----ICKPKMGYTDIL---AVDPD 600
Query: 695 LASGHGPYSFTL-GPNPTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNA-QM 752
P+ F+L +P + R W L +N + A L+ + +E+ IP+ V A Q
Sbjct: 601 EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKN-AGFQEYTIPITVKDRAGQA 659
Query: 753 WQLLVRVIVCRCNVEGQCMRKVGRMKGMPT-KLSAVGILVGTLVAIGIFLILI 804
L+RV +C C QC R R G+ K + + IL+G + + L L+
Sbjct: 660 ATKLLRVNLCECTHPTQC-RATSRSTGVILGKWAILAILLGIALLFSVLLTLV 711
Score = 114 bits (284), Expect = 5e-25
Identities = 123/481 (25%), Positives = 211/481 (43%), Gaps = 77/481 (16%)
Query: 19 KAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGP----FAMDPD 74
K + A + + EN G FPL+L ++ + A+ V SG+ + F ++ D
Sbjct: 134 KRRWAPIPCSMQENSLGPFPLFLQQVE--SDAAQNYTVFYSISGRGVDKEPLNLFYIERD 191
Query: 75 SGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRAR 134
+G L TR +DREE + L DG+ P P+ + V+DEND P F++AIY
Sbjct: 192 TGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFE 251
Query: 135 LSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPK 194
+ +RPG + A+DRDEP T ++ L++ IL Q P SP +F + P G +
Sbjct: 252 VLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPR--SPGLFSVHPSTGVI----- 304
Query: 195 GSTSLDHALER----TYQLLVQVKDMGDQASGHQATATVEVSI----------------- 233
T++ H L+R Y L+++V+DM Q G T+T +++
Sbjct: 305 --TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEA 362
Query: 234 -IESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNA-----EGN 287
+E ++E + + K L +V+++ L+ + G F+++ EG
Sbjct: 363 FVEENAFNVEILRIPIEDKDLINTANWRVNFT------ILKGNENGHFKISTDKETNEGV 416
Query: 288 LYVTRELDREAQAEYLLQVRAQNS--HGEDY-------AAPLELHVLVMDENDNVPICPP 338
L V + L+ E + L++ N D A + +HV +DE P C P
Sbjct: 417 LSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEG---PECTP 473
Query: 339 RDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSG 398
V I E G+++ A D P + N + + +P+ + +D SG
Sbjct: 474 AAQYVRIKENLAVGSKINGYKAYD---PENRNGNGLRYKKLHDPKGWI-----TIDEISG 525
Query: 399 SVTLGVL---PLRAGQNIL--LLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQ 453
S+ + + +N L + VLA+D + S T + V + D+ND+ PE +
Sbjct: 526 SIITSKILDREVETPKNELYNITVLAID----KDDRSCTGTLAVNIEDVNDNPPEILQEY 581
Query: 454 I 454
+
Sbjct: 582 V 582
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 137 bits (344), Expect = 5e-32
Identities = 162/613 (26%), Positives = 271/613 (44%), Gaps = 63/613 (10%)
Query: 66 EGPFAMDPDSGFLLVT--RALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQV 123
+G ++ SG L V + LD E + E QL V E GH + VL+ +DEND
Sbjct: 1728 DGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAE-SSGHRAYCKVAVLI--QDENDNS 1784
Query: 124 PHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLE 183
P F Q+IY+A +S + + A+D D N + + ILS + FQ++
Sbjct: 1785 PCFEQSIYQASVSESQLYNAHVIQVFATDLD--SGLNGLIEYSILS----GNQEEAFQID 1838
Query: 184 PRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEP 243
G + LD+ L +Y L+VQ D G + V+V+ I + P
Sbjct: 1839 ALSGVITT----KAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP 1894
Query: 244 IHLAENLKVLYPHHMAQVHWSGGDV--------HYHLESHPPGPFEVNAE-GNLYVTREL 294
E + P + H S DV + ES+P F ++ G + + + L
Sbjct: 1895 SEAVEITEDSLP-GVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
Query: 295 DREAQAEYLLQVRAQNS-HGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGT 353
D E EY L ++ +S H + A L V V+D NDN P+ V++PE P G
Sbjct: 1954 DFEEMTEYELLIQISDSVHYTEGA----LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGY 2009
Query: 354 EVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLG-VLPLRAGQ 411
V LSA D ++ N ++ Y++LS E F +DP +G++ T+ VL L
Sbjct: 2010 SVLTLSATDLES----NENISYRILSSSKE-------FSIDPKNGTIFTISPVLLLDTIS 2058
Query: 412 NILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAM 471
LV A D G + VE+ + D+N++APEF +SL ED G+ +
Sbjct: 2059 TTQFLVEASD--GGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN-LSLSEDALVGSTLVT 2115
Query: 472 LTAIDADLEPAFRLMDFAIERGDTEGTFGLDWE------PDSGHVRLRLCKNLSYEAAPS 525
+ ID D ++++I G+++ F ++ + P L L +L EA+ S
Sbjct: 2116 FSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASAS 2175
Query: 526 HEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLL 584
HE+V++ P +TA +++ V V PP SY V S P GS +
Sbjct: 2176 HELVILASD-----SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHIT 2230
Query: 585 TIQPSDPISRT---LRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQD 640
+ +D + + + +++++ +E G +E+ +G ++ + L + +T+ V+A D
Sbjct: 2231 VVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLD-YEKMTKFTLTVQASD 2289
Query: 641 TDEPRLSASAPLV 653
++ S + V
Sbjct: 2290 AEKKHFSFAVVFV 2302
Score = 124 bits (311), Expect = 4e-28
Identities = 156/588 (26%), Positives = 251/588 (42%), Gaps = 55/588 (9%)
Query: 47 PREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGH-V 105
P EG G++ S SG F +D SG L T LD E + ++ L V L + DG
Sbjct: 1191 PDEGRNGKVTYSILSGNENM-TFMLDESSGLLTTTCPLDYEMKTQHILTV-LALDDGTPA 1248
Query: 106 LWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRF 165
L Q + V V D ND+ P F Q +Y A + PG +EA DRD NS L+F
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD--SGVNSKLQF 1306
Query: 166 HILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQA 225
I+ A S ++F++ G + +T LD ++ + L V V+D G + +
Sbjct: 1307 EIMPGA----SFELFEINSDTGEVVT----TTILDREIQEVFTLRVLVRDGGFPSL--SS 1356
Query: 226 TATVEVSIIEST------WVSLEPIHLAENLKVLYPHHMAQVHWSGGD---VHYH-LESH 275
T T+ ++ + VS I + EN + + + G+ V YH ++ +
Sbjct: 1357 TTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGN 1416
Query: 276 PPGPFEVN-AEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 334
F +N G L TR LDRE + + L + + ++ + L V V+D ND+ P
Sbjct: 1417 TDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSP 1476
Query: 335 ICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVD 394
P S+ E + GT V LSA D D N Y L D G AF +D
Sbjct: 1477 SFPTLYYQSSVREDAEVGTVVLVLSAVDKDE--GLNGQTEYFL-----TDEASG-AFTID 1528
Query: 395 PTSGSV-TLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQ 453
P SG++ T L A +A D +G S+T ++V VTD+ND+ P +
Sbjct: 1529 PMSGTLKTSNTLDREARSQHTFSAVARD-CSIQGSRSTTVIIKVYVTDVNDNDPVLEQNP 1587
Query: 454 IGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLR 513
PE T V ++ A D DL P ++ +T+ F +D +
Sbjct: 1588 FDVFLSPESPTNQTTV-IVRADDLDLGPNGTVV---FSFAETQSMFSID----------K 1633
Query: 514 LCKNLSYEAAPSHEVVVVVQSVAKLVGPG-PGPGATATVTVLVERVMPPPKLDQESYEAS 572
+ ++ PS E + + K+ G P T + + +E Y+
Sbjct: 1634 YTGEIQFQQNPSSEYFPIWLQL-KVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGL 1692
Query: 573 VPISAPAGSFLLTIQ--PSDPISRTLRFSLVNDSE-GWLCIEKFSGEV 617
V + AG+ ++T++ D I ++++S+ + +E G L + SG++
Sbjct: 1693 VTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQL 1740
Score = 119 bits (297), Expect = 2e-26
Identities = 156/602 (25%), Positives = 263/602 (43%), Gaps = 53/602 (8%)
Query: 76 GFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARL 135
G L+ ALDRE + +++ V + + V V V D ND P F Q + L
Sbjct: 789 GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKEL 848
Query: 136 SRGTRPGIPFLFLE----ASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALAL 191
G P L A D DE N+++ + + S+ S D F+++ G +
Sbjct: 849 HVKVLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSE----DSSDHFKIDANNGEI-- 900
Query: 192 SPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWV----SLEPIHLA 247
+ +T L + +Y++ V D G QA ++V + ++ + +
Sbjct: 901 --RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIP 958
Query: 248 ENLK-------VLYPHHMAQVHWSGGDVHYHLESHPP-GPFEVNAE-GNLYVTRELDREA 298
ENLK + H+ Q H++G +H+ + + G FE+++ G+L++++ELD E
Sbjct: 959 ENLKPTKIMSLIKSSDHLQQ-HYNG-KLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET 1016
Query: 299 QAEYLLQV-RAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTR 357
+ YL +V +S ++ + L + V D+ND+ P +S+ E P GT V
Sbjct: 1017 TSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYV 1076
Query: 358 LSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGS-VTLGVLPLRAGQNILLL 416
+A+D D NS + Y + S P F + P+ G+ VT+ L + ++L
Sbjct: 1077 FNAKDDDG-SFLNSRIQYYIESHNPGT----NPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
Query: 417 VLAMDLA-GAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAI 475
V A D A + ++ + D+NDH P FI+ + EDV G+LV +TA
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVK--EDVTVGSLVHHITAH 1189
Query: 476 DADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSV 535
D D E + ++I G+ TF LD +S + C L YE H + V+
Sbjct: 1190 DPD-EGRNGKVTYSILSGNENMTFMLD---ESSGLLTTTCP-LDYEMKTQHILTVLALDD 1244
Query: 536 AKLVGPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSD---PI 592
P T TVTVL + P Q YEASV + G F+ ++ D +
Sbjct: 1245 GT---PALSSSQTLTVTVL-DVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGV 1300
Query: 593 SRTLRFSLVNDSEGWLC-IEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAP 651
+ L+F ++ + L I +GEV T L + + +T+ V +D P LS++
Sbjct: 1301 NSKLQFEIMPGASFELFEINSDTGEVVTTTILD-REIQEVFTLRVLVRDGGFPSLSSTTT 1359
Query: 652 LV 653
++
Sbjct: 1360 IL 1361
Score = 107 bits (267), Expect = 5e-23
Identities = 116/439 (26%), Positives = 198/439 (45%), Gaps = 57/439 (12%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQ 128
FA+D ++G +++ + LD EE EY+L + + V + ++V V D ND P FSQ
Sbjct: 1938 FAIDQNTGVVVLVKTLDFEEMTEYELLIQIS---DSVHYTEGALVVRVLDVNDNPPVFSQ 1994
Query: 129 AIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGA 188
Y+ + G L L A+D + +N ++ + ILS S F ++P+ G
Sbjct: 1995 DFYQVTVPESIPVGYSVLTLSATDLE----SNENISYRILS------SSKEFSIDPKNGT 2044
Query: 189 L-ALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSI-----------IES 236
+ +SP LD T Q LV+ D G+ +A VE+ I ++S
Sbjct: 2045 IFTISPV--LLLDTI--STTQFLVEASDGGNPDL--RALTLVEIGIEDMNNYAPEFTVKS 2098
Query: 237 TWVSLEPIHLAENLKVLYPH-------HMAQVHWS----GGDVHYHLES---HPPGPFEV 282
+SL L + V + + V +S ++H+E+ H P++
Sbjct: 2099 YNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYK- 2157
Query: 283 NAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPT 342
G L + LDREA A + L + A +S ++ + + V+D NDN P
Sbjct: 2158 -QVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
Query: 343 VSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTL 402
+ E +P G+ +T +SA D D ++ ++Y ++S G E F ++ +G + L
Sbjct: 2217 THVKESTPLGSHITVVSANDRDT--GSHAEIIYNIIS-----GNEKGHFYLEENTGVLYL 2269
Query: 403 GVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPED 462
+ PL + + L + + AE S V V+V D NDHAP+F+ S I +PE+
Sbjct: 2270 -IKPLDY-EKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCI-VPEN 2326
Query: 463 VEPGTLVAMLTAIDADLEP 481
+ + + + A+D D P
Sbjct: 2327 LPISSTICSINALDFDAGP 2345
Score = 95.1 bits (235), Expect = 2e-19
Identities = 154/611 (25%), Positives = 244/611 (39%), Gaps = 63/611 (10%)
Query: 68 PFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVL------WGPQPVLVHVKDEND 121
PF + P G L+ LDRE L VT Q +V Q V++ V D N
Sbjct: 1104 PFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNP 1163
Query: 122 QVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQ 181
F A + ++ G+ + A D DE N + + ILS F
Sbjct: 1164 TFISFPNAHVKEDVTVGSL----VHHITAHDPDE--GRNGKVTYSILSGNENM----TFM 1213
Query: 182 LEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEV-SIIESTWVS 240
L+ G L + LD+ ++ + L V D G A T TV V + + V
Sbjct: 1214 LDESSGLLTT----TCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF 1269
Query: 241 LEPIHLA-----ENLKVLYPHHMAQVHWSGGDVHYHLESHPPGP---FEVNAE-GNLYVT 291
+ ++ A +N A SG + E P FE+N++ G + T
Sbjct: 1270 KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTT 1329
Query: 292 RELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPP 351
LDRE Q + L+V ++ ++ + V DEND+ P + + E P
Sbjct: 1330 TILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP 1389
Query: 352 GTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAG 410
T L A D DA N V Y ++ DG F ++ SG + T L
Sbjct: 1390 EVVYTVL-ASDMDA--GNNRAVEYHII-----DGNTDECFTINEMSGELSTTRALDREQI 1441
Query: 411 QNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVA 470
N L++L DL + SS ++V V D NDH+P F T S+ ED E GT+V
Sbjct: 1442 SNFTLVILCSDL--GDPPRSSVIHLQVRVLDANDHSPSFPTLYY-QSSVREDAEVGTVVL 1498
Query: 471 MLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVV 530
+L+A+D D + F + + G F +D P SG L+ L EA H
Sbjct: 1499 VLSAVDKDEGLNGQTEYFLTD--EASGAFTID--PMSG--TLKTSNTLDREARSQH---- 1548
Query: 531 VVQSVAKLVGPGPGPGATATVTVLVERVMP-PPKLDQESYEASVPISAPAGSFLLTIQPS 589
+VA+ T + V V V P L+Q ++ + +P + ++
Sbjct: 1549 TFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRAD 1608
Query: 590 D---PISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDE--P 644
D + T+ FS +++ I+K++GE+ Q+ + + + ++ + TD+ P
Sbjct: 1609 DLDLGPNGTVVFSFA-ETQSMFSIDKYTGEIQFQQN----PSSEYFPIWLQLKVTDQGIP 1663
Query: 645 RLSASAPLVIH 655
+ + LVIH
Sbjct: 1664 ARTTTGLLVIH 1674
Score = 87.0 bits (214), Expect = 6e-17
Identities = 154/636 (24%), Positives = 243/636 (38%), Gaps = 106/636 (16%)
Query: 56 VLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVH 115
+ SGD G G F++ P G + + LD E Q L V ++ + V +
Sbjct: 415 ISSGDLG----GKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE-VNIT 469
Query: 116 VKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQP 175
V D ND P F + R+S+ T PG A DRD N +R+ I A P
Sbjct: 470 VMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD--SGRNGLIRYSI-----ASP 522
Query: 176 SPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIE 235
P +F ++ LG L L+ GS E T L + + + QA+ T +E
Sbjct: 523 QPGVFAIDRALGVLFLN--GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHS 580
Query: 236 STWV---SLEPIHLAENLKVLYPHHMAQVHWSG-----GDVHYHLE-SHPPGPFEVNA-E 285
+W + + ++E+L + Q H G + Y LE S F +
Sbjct: 581 PSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT 640
Query: 286 GNLYVTRELDREAQAEYLLQVRAQ-NSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVS 344
G +Y+ R+ D E+ Y +V A G + V V DENDN P +
Sbjct: 641 GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLK 700
Query: 345 IPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSP------EPEDGVEGRAFQVDPTSG 398
+ E P + +++A D D+ N ++Y LLS P G G + + G
Sbjct: 701 VEESPVPQGVIGKITAIDMDS--GKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADG 758
Query: 399 SV-----------------TLGVLPLRAGQNILLLVLAMD-----------LAGAEGG-- 428
+ L L G+ L+ +A+D L G
Sbjct: 759 AAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPP 818
Query: 429 FSSTCEVEVAVTDINDHAPEFITSQIGP---ISLPEDVEPGTLVAMLTAIDADLEPAFRL 485
++T V V+VTDIND+ P F G + + E LV + A D D
Sbjct: 819 RNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPD------- 871
Query: 486 MDFAIERGDTEGTFGLDWEPDSGHVR-------LRLCKNLSYEAAPSHEVVVVV--QSVA 536
E + E T+ + E S H + +R LSY+ PS+ + V+ Q V
Sbjct: 872 -----EGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVP 926
Query: 537 KLVGPGPGPGATATVTVLVERVMPPPK----LDQESYEASVPISAPAGSFLLTIQPSDPI 592
L G A V + +V+P K + Q +P + + I+ SD +
Sbjct: 927 PLQG-------QAVVNI---QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
Query: 593 SR----TLRFSLV-NDSEGWLCIEKFSGEVHTAQSL 623
+ L FS+V +D +G I+ +G++ ++ L
Sbjct: 977 QQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKEL 1012
Score = 52.8 bits (125), Expect = 1e-06
Identities = 71/312 (22%), Positives = 126/312 (40%), Gaps = 24/312 (7%)
Query: 285 EGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPI----CPPRD 340
EG L LDRE + + + V + A + ++V V D NDN P P ++
Sbjct: 788 EGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKE 847
Query: 341 PTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV 400
V + E P VT + A+D D N+ V Y + S + D F++D +G +
Sbjct: 848 LHVKVLEGQPVNMLVTTVFAKDPDE--GNNAEVTYSVSSEDSSD-----HFKIDANNGEI 900
Query: 401 -TLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISL 459
T +L + + V+A D V + V ++ ++ I + +
Sbjct: 901 RTTTILSYDYRPSYRMSVIATDQGVPP--LQGQAVVNIQVIPLS-KGRAIMSQNIRHLII 957
Query: 460 PEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLS 519
PE+++P +++++ + D + + F+I D +G F E DS L L K L
Sbjct: 958 PENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHF----EIDSSTGDLFLSKELD 1013
Query: 520 YEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVE-RVMPPPKLDQESYEASVPISAP 578
YE + V+ +K + +T +++ VE + P E SV + P
Sbjct: 1014 YETTSHYLFRVITTDHSKNL----SLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVP 1069
Query: 579 AGSFLLTIQPSD 590
G+ + D
Sbjct: 1070 IGTLVYVFNAKD 1081
Score = 43.5 bits (101), Expect = 8e-04
Identities = 64/263 (24%), Positives = 104/263 (39%), Gaps = 34/263 (12%)
Query: 50 GAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTL-EMQDGHVLWG 108
G+ +I+ + SG +G F ++ ++G L + + LD E+ ++ L V + + H +
Sbjct: 2240 GSHAEIIYNIISGNE-KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFA 2298
Query: 109 PQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHIL 168
V V V D+ND P F + + + + A D D +L + I+
Sbjct: 2299 V--VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFD--AGPYGELTYSIV 2354
Query: 169 SQA----PAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQ 224
S D+F ++P G + LD+ Y L VQ KD GD
Sbjct: 2355 SPCFLTHGMSYDHDLFLIDPLTGDI----HAKQILDYENGNKYCLTVQAKDKGD------ 2404
Query: 225 ATATVEVSIIESTWVSLEPIHLAENLKVLYPHH------MAQVHWSGGD------VHYHL 272
ATA++ V + EPI + P + +V S D + Y L
Sbjct: 2405 ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
Query: 273 ESHPPGPFEVN-AEGNLYVTREL 294
+ P F VN GN+Y+ R L
Sbjct: 2465 GTSSPF-FSVNKTNGNIYLIRAL 2486
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/139 (26%), Positives = 62/139 (44%), Gaps = 19/139 (13%)
Query: 272 LESHPPGPFEVNA-EGNLYVTRELDREAQ-AEYLLQVRAQNSHGE----------DYAAP 319
L P F ++ +G + V++++DRE A Y L V A++ + +A
Sbjct: 101 LSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQ 160
Query: 320 LELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLS 379
+ V + D NDN P+ P SI + + PGTE+ + A D D+ +Y ++
Sbjct: 161 AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSG-------IYGTVA 213
Query: 380 PEPEDGVEGRAFQVDPTSG 398
E G F +D T+G
Sbjct: 214 YELIPGNVSSLFTIDSTTG 232
Score = 39.3 bits (90), Expect = 0.015
Identities = 42/161 (26%), Positives = 70/161 (43%), Gaps = 23/161 (14%)
Query: 356 TRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEG----RAFQVDPTSGSVTLG--VLPLRA 409
T ++A DAD+ +Y + DG +AF++DP G + + + R
Sbjct: 77 TEVTASDADSG-------LYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERD 129
Query: 410 GQNILLLVLAMD--------LAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPE 461
LLV A D LA +GG S+ V V + D+ND+ P F S S+ +
Sbjct: 130 PATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTY-VTSISD 188
Query: 462 DVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLD 502
+ +PGT + + A D D + + + + G+ F +D
Sbjct: 189 ETQPGTEIINVLATDQD-SGIYGTVAYELIPGNVSSLFTID 228
Score = 39.3 bits (90), Expect = 0.015
Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 15/99 (15%)
Query: 69 FAMDPDSGFLLVTRALDRE-EQAEYQLQVTLEMQDG------HV------LWGPQPVLVH 115
F +DP G + V++ +DRE + A Y L V E +DG H+ L V V
Sbjct: 109 FRIDPHDGQICVSQDIDRERDPATYDLLV--EAKDGDEQRMTHLALVKGGLSAQAFVRVD 166
Query: 116 VKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRD 154
++D ND P F+ + Y +S T+PG + + A+D+D
Sbjct: 167 LEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD 205
Score = 30.8 bits (68), Expect = 5.4
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 3/70 (4%)
Query: 176 SPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIE 235
+P F+++P G + +S D A TY LLV+ KD +Q H A +S
Sbjct: 105 APQAFRIDPHDGQICVSQDIDRERDPA---TYDLLVEAKDGDEQRMTHLALVKGGLSAQA 161
Query: 236 STWVSLEPIH 245
V LE ++
Sbjct: 162 FVRVDLEDVN 171
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 136 bits (342), Expect = 9e-32
Identities = 155/582 (26%), Positives = 254/582 (43%), Gaps = 54/582 (9%)
Query: 266 GDVHYHLESHPPGPFEVNAE--GNLYVTRELDREAQAEYLLQVRA-QNSHGEDYAAPLEL 322
G++ Y L G V E G+++ ++LDRE ++ Y+L+ +A G E
Sbjct: 86 GNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEF 145
Query: 323 HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPE 381
+ + D NDN P T S+PE+S GT V +++A DAD NS VVY +L +
Sbjct: 146 IIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQ 205
Query: 382 PEDGVEGRAFQVDPTSGSVTLGVLPLRAGQN---ILLLVLAMDLAGAEGGFSSTCEVEVA 438
P F VDP SG + LP + +N +++ A D+ G GG S T V +
Sbjct: 206 PY-------FSVDPESGIIKTA-LPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNIT 257
Query: 439 VTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGT 498
+TD+N++ P F S + PE V GT + + A D D+ M+++I GD
Sbjct: 258 LTDVNNNPPRFPQSTY-QFNSPESVPLGTHLGRIKANDPDVGENAE-MEYSIAEGDGADM 315
Query: 499 FGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGP-----GP-GATATVT 552
F + + D+ + + +NL +E ++++ ++ A P P GP TA V
Sbjct: 316 FDVITDKDTQEGIITVKQNLDFE----NQMLYTLRVDASNTHPDPRFLHLGPFKDTAVVK 371
Query: 553 VLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRT--LRFSL--VNDSEGWL 608
+ VE + PP + SY V GS + + DP +R +++S+ D +
Sbjct: 372 ISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYSVDRHTDMDRIF 431
Query: 609 CIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLA 668
I +G + T ++L + + + V A + + P+ S+ P+ I L A A
Sbjct: 432 GIHSENGSIFTLKALD-RESSPWHNITVTATEINNPKQSSHIPVFIRILDIND-HAPEFA 489
Query: 669 PVPSQYLCTPRQDHGLI--VSGPSKDPDLASGHGPY-----SFTLGPNPTV--QRDWRLQ 719
++C + LI VS KD D GH + FTL PN T+ +D
Sbjct: 490 MYYETFVCENAKPGQLIQTVSVMDKD-DPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAG 548
Query: 720 TLNGSHAYLTLALHWVEPREHIIPVVVSHN---AQMWQLLVRVIVCRCNVEGQCMRKVGR 776
+ Y + +++P+++ N Q + + VC C+ +G
Sbjct: 549 IMTRKDGYSRNKM-----STYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAE 603
Query: 777 MKGMPTKLSAVGILVGTLVAIGIFLILI--FTHWTMSRKKDP 816
+ LS G LV L+ + I LIL+ F RKK+P
Sbjct: 604 ALILSAGLS-TGALVAILLCVLILLILVVLFAALKRQRKKEP 644
Score = 105 bits (261), Expect = 2e-22
Identities = 118/484 (24%), Positives = 211/484 (43%), Gaps = 62/484 (12%)
Query: 31 ENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDREE 88
E Y G Y+ KL ++ +G + +L+GD + F +D ++G + + LDREE
Sbjct: 64 EEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSL---FVIDENTGDIHAAKKLDREE 120
Query: 89 QAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLF 147
++ Y L+ ++ + G + ++ + D ND P F++ +Y A + + G +
Sbjct: 121 KSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQ 180
Query: 148 LEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTY 207
+ A+D D+ NS + + Q QP F ++P G + + + Y
Sbjct: 181 VTATDADDANYGNSAKVVYSILQG--QP---YFSVDPESGIIKTA---LPDMSRENREQY 232
Query: 208 QLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENL-------KVLYPHHMAQ 260
Q+++Q KDMG Q G T TV +++ T V+ P ++ V H+ +
Sbjct: 233 QVVIQAKDMGGQMGGLSGTTTVNITL---TDVNNNPPRFPQSTYQFNSPESVPLGTHLGR 289
Query: 261 VHWSGGDV------HYHL-ESHPPGPFEV-----NAEGNLYVTRELDREAQAEYLLQVRA 308
+ + DV Y + E F+V EG + V + LD E Q Y L+V A
Sbjct: 290 IKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDA 349
Query: 309 QNSHGEDYAAPLELHV----------LVMDENDNVPICPPRDPTVSIPELSPPGTEVTRL 358
N+H + P LH+ + +++ D P+ + + E G+ + ++
Sbjct: 350 SNTHPD----PRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQV 405
Query: 359 SAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLV 417
+A D DA N+ + Y + D R F + +GS+ TL L + + V
Sbjct: 406 TAYDPDA---RNNLIKYSVDRHTDMD----RIFGIHSENGSIFTLKALDRESSPWHNITV 458
Query: 418 LAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDA 477
A ++ + SS V + + DINDHAPEF + + E+ +PG L+ ++ +D
Sbjct: 459 TATEINNPKQ--SSHIPVFIRILDINDHAPEF--AMYYETFVCENAKPGQLIQTVSVMDK 514
Query: 478 DLEP 481
D P
Sbjct: 515 DDPP 518
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 133 bits (334), Expect = 8e-31
Identities = 146/586 (24%), Positives = 260/586 (44%), Gaps = 37/586 (6%)
Query: 255 PHHMAQVHWSG----GDVHYHLESHPPGPFEV--NAEGNLYVTRELDREAQAEYLLQVRA 308
P ++ ++H + G V Y L G + + G+++ T+ LDRE + Y+L +A
Sbjct: 71 PQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQA 130
Query: 309 QNSHGEDYAAP-LELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPG 367
+ P E + V D NDN P V++PE+S GT V +++A DAD P
Sbjct: 131 IDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPT 190
Query: 368 SPNS-HVVYQLLSPEPEDGVEGRAFQVDPTSGSV--TLGVLPLRAGQNILLLVLAMDLAG 424
NS VVY +L +P F VDP +G + L + A ++ +++ A D+AG
Sbjct: 191 YGNSARVVYSILQGQP-------YFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAG 243
Query: 425 AEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFR 484
GG S + V + +TD+ND+ P F + +PE + G+ V + A DAD +
Sbjct: 244 QVGGLSGSTTVNITLTDVNDNPPRFPQKHY-QLYVPESAQVGSAVGKIKANDAD-TGSNA 301
Query: 485 LMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSV---AKLVGP 541
M ++I GD G F + + ++ L L K L+YE S+ + + + +
Sbjct: 302 DMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHL 361
Query: 542 GPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPIS-RTLRFSL 600
GP AT + ++V V PP SY V +A G+ + T+ DP S +L
Sbjct: 362 GPFKDAT-MLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYF 420
Query: 601 VN---DSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFL 657
+N + + + I+ +G + T + L + Y + V A + D P L + + I L
Sbjct: 421 INYNVEDDRFFNIDANTGTIRTTKVLD-REETPWYNITVTASEIDNPDLLSHVTVGIRVL 479
Query: 658 KAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWR 717
P LA +C + +I + + D D + ++F L V ++
Sbjct: 480 DVNDNPP-ELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFT 538
Query: 718 LQ-TLNGSHAYLTLALHWVEPREHI--IPVVVSHN---AQMWQLLVRVIVCRCNVEGQCM 771
L+ + + + LT + + + +P+++S + + + VC C +G+ +
Sbjct: 539 LKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGR-V 597
Query: 772 RKVGRMKGMPTKLSAVGILVGTLVAIGIFLILIFTHWTMSR-KKDP 816
R + + + G L+ L+ + I L ++ T+ R KK+P
Sbjct: 598 RTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEP 643
Score = 98.2 bits (243), Expect = 3e-20
Identities = 115/479 (24%), Positives = 204/479 (42%), Gaps = 54/479 (11%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E + G P Y+ KL + +G + +L+G+ F +D +G + T++LDR
Sbjct: 62 VLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTI---FIIDDTTGDIHSTKSLDR 118
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
E++ Y L ++ + L ++ V+D ND P F+ Y + + G
Sbjct: 119 EQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSV 178
Query: 146 LFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER 205
L + A+D D+P NS + + Q QP F ++P+ G + + ++D
Sbjct: 179 LQVTATDADDPTYGNSARVVYSILQ--GQP---YFSVDPKTGVIRTA---LHNMDREARE 230
Query: 206 TYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQV---- 261
Y +++Q KDM Q G + TV +++ T V+ P + LY AQV
Sbjct: 231 HYSVVIQAKDMAGQVGGLSGSTTVNITL---TDVNDNPPRFPQKHYQLYVPESAQVGSAV 287
Query: 262 ---------HWSGGDVHYH-LESHPPGPFEVNA-----EGNLYVTRELDREAQAEYLLQV 306
S D+ Y + G F ++ EG L + + L+ E + Y L +
Sbjct: 288 GKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNI 347
Query: 307 RAQNSHGE---DYAAPLE---LHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA 360
N+H + + P + + +++ + D P+ + + E + GT V + A
Sbjct: 348 EGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLA 407
Query: 361 EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLVLA 419
+D P S NS V Y ++ ED R F +D +G++ T VL + V A
Sbjct: 408 QD---PDSTNSLVRY-FINYNVED---DRFFNIDANTGTIRTTKVLDREETPWYNITVTA 460
Query: 420 MDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD 478
++ + S V + V D+ND+ PE I + E+ +PG ++ ++A D D
Sbjct: 461 SEIDNPD--LLSHVTVGIRVLDVNDNPPELAREY--DIIVCENSKPGQVIHTISATDKD 515
Score = 47.8 bits (112), Expect = 4e-05
Identities = 42/168 (25%), Positives = 69/168 (41%), Gaps = 7/168 (4%)
Query: 69 FAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQ 128
F +D ++G + T+ LDREE Y + VT D L V + V D ND P ++
Sbjct: 431 FNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAR 490
Query: 129 AIYRARLSRGTRPGIPFLFLEASDRDEPGTANSD-LRFHILSQAPAQPSPDMFQLEPRLG 187
Y + ++PG + A+D+D+ AN F + + P P+ F L+
Sbjct: 491 E-YDIIVCENSKPGQVIHTISATDKDD--FANGPRFNFFLDERLPVNPN---FTLKDNED 544
Query: 188 ALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIE 235
A ++ Y L + + D G + +T T+ V E
Sbjct: 545 NTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACE 592
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 132 bits (333), Expect = 1e-30
Identities = 170/649 (26%), Positives = 259/649 (39%), Gaps = 75/649 (11%)
Query: 49 EGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVL 106
EG E ++ + G + + G F +D +G + LDRE + + L+V
Sbjct: 274 EGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPR 333
Query: 107 WGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFH 166
+ V VKD ND P F Q+ YR R+ G L + ASDRD P N++LR+
Sbjct: 334 SATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSP--INANLRYR 391
Query: 167 ILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQAT 226
+L A D+FQL G ++ LD YQLLV+ D G AT
Sbjct: 392 VLGGA-----WDVFQLNESSGVVST----RAVLDREEAAEYQLLVEANDQGRNPGPLSAT 442
Query: 227 ATVEVSI----------IESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYH-LESH 275
ATV + + E +V P + N VL + +HY L +
Sbjct: 443 ATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGN 502
Query: 276 PPGPFEVNA-EGNLYVTRELDREAQAEYLLQVRAQ--------NSHGEDYAAPLELHVLV 326
G F +++ G L V LD E +Y L ++AQ NS G + V V
Sbjct: 503 VAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSG-------VVSVQV 555
Query: 327 MDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLL-------- 378
+D NDN PI ++ E P G V + A DAD+ N+ + Y+L+
Sbjct: 556 LDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS--GENARLHYRLVDTASTFLG 613
Query: 379 ----SPEPEDGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAMDLAGAEGGFSSTC 433
P+ FQ+ +SG +T+ L ++ V A+D SS+
Sbjct: 614 GGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPP--MSSST 671
Query: 434 EVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERG 493
V + V D+ND+ P F T + L ED G+ V L A D D A ++ + + G
Sbjct: 672 SVSITVLDVNDNDPVF-TQPTYELRLNEDAAVGSSVLTLQARDRD---ANSVITYQLTGG 727
Query: 494 DTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTV 553
+T F L + G + L L L Y+ + + V + TA V +
Sbjct: 728 NTRNRFALSSQRGGGLITLAL--PLDYKQEQQYVLAVTASDGTR--------SHTAHVLI 777
Query: 554 -LVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSD-PISRTLRFS-LVNDSEGWLCI 610
+ + P Y SV P G+ + T+ +D R + ++ D I
Sbjct: 778 NVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRI 837
Query: 611 EKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKA 659
+ SG ++T L + YT+ + AQD P+ S + L I L A
Sbjct: 838 DPDSGTMYTMMELD-YENQVAYTLTIMAQDNGIPQKSDTTTLEILILDA 885
Score = 131 bits (330), Expect = 2e-30
Identities = 160/580 (27%), Positives = 251/580 (43%), Gaps = 56/580 (9%)
Query: 68 PFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFS 127
PF + SG++ V LDREE Y V + V + V D ND P F+
Sbjct: 629 PFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
Query: 128 QAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLG 187
Q Y RL+ G L L+A DRD ANS + + Q + + F L + G
Sbjct: 689 QPTYELRLNEDAAVGSSVLTLQARDRD----ANSVITY----QLTGGNTRNRFALSSQRG 740
Query: 188 ALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLA 247
++ + LD+ E+ Y L V D H A + V+ + + H
Sbjct: 741 GGLITL--ALPLDYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYT 795
Query: 248 ENLKVLYPHHMAQVHWSGGD--------VHYHLESHPPGPFEVNAE-GNLYVTRELDREA 298
++ P + S D + Y ++ P F ++ + G +Y ELD E
Sbjct: 796 VSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP-QFRIDPDSGTMYTMMELDYEN 854
Query: 299 QAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRL 358
Q Y L + AQ++ + L +L++D NDN P SI E +PP T + ++
Sbjct: 855 QVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQV 914
Query: 359 SAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSV-TLGVLPLRAGQNILLLV 417
SA D D+ PN ++Y + DG F ++PTSG + T L L
Sbjct: 915 SATDRDS--GPNGRLLYTFQGGDDGDG----DFYIEPTSGVIRTQRRLDRENVAVYNLWA 968
Query: 418 LAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDA 477
LA+D G+ S++ E++V + DIND+AP F ++ + + E+ G++VA + A D
Sbjct: 969 LAVD-RGSPTPLSASVEIQVTILDINDNAPMFEKDEL-ELFVEENNPVGSVVAKIRANDP 1026
Query: 478 DLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSV-A 536
D P ++M + I GD F LD LR L +E E V+VVQ+ A
Sbjct: 1027 DEGPNAQIM-YQIVEGDMRHFFQLDLLNGD----LRAMVELDFEV--RREYVLVVQATSA 1079
Query: 537 KLVGPGPGPGATATVTV-LVERVMPPPKLDQ-----ESYEASVPISAPAGSFLLTIQPSD 590
LV + ATV + LV++ PP L +Y + S P G + I D
Sbjct: 1080 PLV-------SRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHD 1131
Query: 591 P-ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQP 628
P +S +L ++ V +E L ++ +GE+ ++ L +P
Sbjct: 1132 PDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRP 1171
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/164 (26%), Positives = 65/164 (39%), Gaps = 11/164 (6%)
Query: 50 GAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQL-QVTLEMQDGHVLWG 108
G G+++ + G +G F ++P SG + R LDRE A Y L + ++ L
Sbjct: 922 GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
Query: 109 PQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHIL 168
+ V + D ND P F + + G + A+D DE A I+
Sbjct: 982 SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNA------QIM 1035
Query: 169 SQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQ 212
Q FQL+ G L + LD + R Y L+VQ
Sbjct: 1036 YQIVEGDMRHFFQLDLLNGDL----RAMVELDFEVRREYVLVVQ 1075
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 132 bits (333), Expect = 1e-30
Identities = 144/557 (25%), Positives = 246/557 (44%), Gaps = 37/557 (6%)
Query: 280 FEVN-AEGNLYVTRELDREAQAEYLLQVRAQN-SHGEDYAAPLELHVLVMDENDNVPICP 337
F++N G+++ + LDRE +AEY L +A + + P E + V D NDN P
Sbjct: 109 FQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFL 168
Query: 338 PRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPEPEDGVEGRAFQVDPT 396
++PE+S GT VT ++A DAD P NS +VY +L +P F ++P
Sbjct: 169 NGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPY-------FSIEPE 221
Query: 397 SGSVTLGV--LPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQI 454
+ + + + A + L+++ A D+ G GG S T + V +TD+ND+ P+F S +
Sbjct: 222 TAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQS-L 280
Query: 455 GPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGL--DWEPDSGHVRL 512
S+PEDV GT + + A D D+ + + I GD F + D + G +RL
Sbjct: 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQ-SSYDIIDGDGTALFEITSDAQAQDGIIRL 339
Query: 513 RLCKNLSYEAAPSHEVVVVVQSV---AKLVGPGPGPGATATVTVLVERVMPPPKLDQESY 569
R K L +E S+ + V +V + G GP TATV ++VE PP +Y
Sbjct: 340 R--KPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKD-TATVKIVVEDADEPPVFSSPTY 396
Query: 570 EASVPISAPAGSFLLTIQPSDP--ISRTLRFSL--VNDSEGWLCIEKFSGEVHTAQSLQG 625
V +A S + + DP S +RFS+ D E I G++ A L
Sbjct: 397 LLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLD- 455
Query: 626 AQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLI 685
+ + + + A + + P+ I L A A +LC + +I
Sbjct: 456 RELSVWHNITIIATEIRNHSQISRVPVAIKVLDVND-NAPEFASEYEAFLCENGKPGQVI 514
Query: 686 VSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPRE----HI 741
+ + D D + ++L P ++ ++ N ++ LA H R+ ++
Sbjct: 515 QTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK-NEDNSLSILAKHNGFNRQKQEVYL 573
Query: 742 IPVVVSHNAQ---MWQLLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIG 798
+P+++S + + + VC C+ +G +P LS +G L+ L I
Sbjct: 574 LPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLS-MGALIAILACII 632
Query: 799 IFLILIFTHWTMSRKKD 815
+ L+++ T+ R K+
Sbjct: 633 LLLVIVVLFVTLRRHKN 649
Score = 99.8 bits (247), Expect = 9e-21
Identities = 113/479 (23%), Positives = 201/479 (41%), Gaps = 54/479 (11%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E + G P+ + +L + +I +LSGD F ++ +G + + LDR
Sbjct: 70 VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTI---FQINDVTGDIHAIKRLDR 126
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EE+AEY L ++ + L P ++ V+D ND P F Y A + + G
Sbjct: 127 EEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSV 186
Query: 146 LFLEASDRDEPGTANS-DLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALE 204
+ A+D D+P NS L + IL P F +EP A+ ++D +
Sbjct: 187 TNVTATDADDPVYGNSAKLVYSILEGQP------YFSIEPE---TAIIKTALPNMDREAK 237
Query: 205 RTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENL-------KVLYPHH 257
Y +++Q KDMG + G T T+ V++ T V+ P A++L V+
Sbjct: 238 EEYLVVIQAKDMGGHSGGLSGTTTLTVTL---TDVNDNPPKFAQSLYHFSVPEDVVLGTA 294
Query: 258 MAQVHWSGGDVHYHLES-------HPPGPFEVNA-----EGNLYVTRELDREAQAEYLLQ 305
+ +V + D+ + +S FE+ + +G + + + LD E + Y L+
Sbjct: 295 IGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLK 354
Query: 306 VRAQNSH------GEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLS 359
V A N H G +V+++ D P+ + + E + + + +++
Sbjct: 355 VEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVT 414
Query: 360 AEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLA 419
A D D SP + + E R F ++ G +TL PL ++ +
Sbjct: 415 ARDPDITSSPIRFSIDRHTDLE-------RQFNINADDGKITLAT-PLDRELSVWHNITI 466
Query: 420 MDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDAD 478
+ S V + V D+ND+APEF + L E+ +PG ++ ++A+D D
Sbjct: 467 IATEIRNHSQISRVPVAIKVLDVNDNAPEFASEY--EAFLCENGKPGQVIQTVSAMDKD 523
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/166 (22%), Positives = 67/166 (40%), Gaps = 5/166 (3%)
Query: 66 EGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPH 125
E F ++ D G + + LDRE + + + H PV + V D ND P
Sbjct: 436 ERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPE 495
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F+ Y A L +PG + A D+D+P + L + +L + P+ + + E
Sbjct: 496 FASE-YEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFL-YSLLPEMVNNPNFTIKKNEDN 553
Query: 186 LGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEV 231
++ G + + Y L + + D G+ +T T+ V
Sbjct: 554 SLSILAKHNG---FNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 131 bits (329), Expect = 3e-30
Identities = 153/578 (26%), Positives = 248/578 (42%), Gaps = 43/578 (7%)
Query: 266 GDVHYHLESHPPGPFEV--NAEGNLYVTRELDREAQAEYLLQVRA-QNSHGEDYAAPLEL 322
G++ Y L G V + GN++ T+ LDRE +A+Y L +A P E
Sbjct: 86 GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEF 145
Query: 323 HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPE 381
V V D NDN P ++PE S GT V +++A DAD P NS +VY +L +
Sbjct: 146 IVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQ 205
Query: 382 PEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTD 441
P VE + + L + A + +++ A D+ G GG S T +V + +TD
Sbjct: 206 PYFSVEAQTGII-----RTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTD 260
Query: 442 INDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGL 501
+ND+ P+F S + +S+ E PG V + A D D+ L+ + I GD +F +
Sbjct: 261 VNDNPPKFPQS-VYQMSVSEAAVPGEEVGRVKAKDPDIGEN-GLVTYNIVDGDGMESFEI 318
Query: 502 --DWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSV---AKLVGPGPGPGATATVTVLVE 556
D+E G ++L+ K + +E ++ + V +V K + GP T TV + VE
Sbjct: 319 TTDYETQEGVIKLK--KPVDFETKRAYSLKVEAANVHIDPKFISNGPFKD-TVTVKISVE 375
Query: 557 RVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDP--ISRTLRFSL--VNDSEGWLCIEK 612
PP SY V +A AG+ + + DP + +R+S+ D + + I
Sbjct: 376 DADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINP 435
Query: 613 FSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPS 672
G + T + L + + V A + A P+ I L AP
Sbjct: 436 EDGFIKTTKPLDREETA-WLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEG 494
Query: 673 QYLCTPRQDHGL----IVSGPSKDPDLASGHGPYSFTLGP----NPT-VQRDWRLQTLNG 723
++C Q L IV+ + D D + + F+L P NP RD R T
Sbjct: 495 -FICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNT--- 550
Query: 724 SHAYLTLALHWVEPRE-HIIPVVVSHNA---QMWQLLVRVIVCRCNVEGQCMRKVGRMKG 779
+ Y + ++ +++P+V+S + + VC C+V G +
Sbjct: 551 AGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYI 610
Query: 780 MPTKLSAVGILVGTLVAIGIFLILIFTHWTMSR-KKDP 816
+ LS G L+ L I I L+++ T+ R KK+P
Sbjct: 611 LNAGLS-TGALIAILACIVILLVIVVLFVTLRRQKKEP 647
Score = 98.6 bits (244), Expect = 2e-20
Identities = 114/469 (24%), Positives = 192/469 (40%), Gaps = 58/469 (12%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E Y G P+ + +L + +G I +LSG+ F +D SG + T+ LDR
Sbjct: 62 VIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTI---FVIDDKSGNIHATKTLDR 118
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EE+A+Y L ++ L P +V V+D ND P F Y A + + G
Sbjct: 119 EERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSV 178
Query: 146 LFLEASDRDEPGTANS-DLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALE 204
+ + ASD D+P NS L + IL P F +E + G + + ++D +
Sbjct: 179 IQVTASDADDPTYGNSAKLVYSILEGQP------YFSVEAQTGIIRTA---LPNMDREAK 229
Query: 205 RTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWS 264
Y +++Q KDMG G T V +++ T V+ P ++ +Y +++
Sbjct: 230 EEYHVVIQAKDMGGHMGGLSGTTKVTITL---TDVNDNPPKFPQS---VYQMSVSEAAVP 283
Query: 265 G----------------GDVHYHL-ESHPPGPFEVNA-----EGNLYVTRELDREAQAEY 302
G G V Y++ + FE+ EG + + + +D E + Y
Sbjct: 284 GEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAY 343
Query: 303 LLQVRAQNSHGED---YAAPLELHVLV---MDENDNVPICPPRDPTVSIPELSPPGTEVT 356
L+V A N H + P + V V +++ D P+ + E + GT V
Sbjct: 344 SLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVG 403
Query: 357 RLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLL 416
R+ A+D DA SP + + + + R F ++P G + PL + L
Sbjct: 404 RVHAKDPDAANSPIRYSIDRHTDLD-------RFFTINPEDGFIKT-TKPLDREETAWLN 455
Query: 417 VLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEP 465
+ + V + V D+ND+AP+F G I + +P
Sbjct: 456 ITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKP 504
Score = 64.7 bits (156), Expect = 3e-10
Identities = 96/435 (22%), Positives = 177/435 (40%), Gaps = 43/435 (9%)
Query: 69 FAMDPDSGFLLVTRA-LDREEQAEYQLQVTLEMQDGHV--LWGPQPVLVHVKDENDQVPH 125
F+++ +G + +DRE + EY + + + GH+ L G V + + D ND P
Sbjct: 208 FSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPK 267
Query: 126 FSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPR 185
F Q++Y+ +S PG ++A D D N + ++I+ + E +
Sbjct: 268 FPQSVYQMSVSEAAVPGEEVGRVKAKDPDI--GENGLVTYNIVDGDGMESFEITTDYETQ 325
Query: 186 LGALALSPKGSTSLDHALERTYQLLVQVKDMGDQA-----SGHQATATVEVSIIES---- 236
G + L +D +R Y L V+ ++ + T TV++S+ ++
Sbjct: 326 EGVIKL----KKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPP 381
Query: 237 TWVSLEPIH-LAENL---KVLYPHHMAQVHWSGGDVHYHLESHPPGP--FEVNAE-GNLY 289
+++ IH + EN V+ H + + Y ++ H F +N E G +
Sbjct: 382 MFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIK 441
Query: 290 VTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP-ICPPRDPTVSIPEL 348
T+ LDRE A + V A H A + + + V+D NDN P P + + +
Sbjct: 442 TTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQ 501
Query: 349 SPP--GTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLP 406
+ P + +SA+D D + ++ L P + + F V + T GV
Sbjct: 502 TKPLSNQPIVTISADDKDDTAN-GPRFIFSL----PPEIIHNPNFTVRDNRDN-TAGVYA 555
Query: 407 LRAG-----QNILLLVLAMDLAGAEG-GFSSTCEVEVAVTDINDHAPEFITSQIGPISLP 460
R G Q++ LL + + G ++T ++V D+N ++ L
Sbjct: 556 RRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNG---ALLSCNAEAYILN 612
Query: 461 EDVEPGTLVAMLTAI 475
+ G L+A+L I
Sbjct: 613 AGLSTGALIAILACI 627
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 130 bits (327), Expect = 5e-30
Identities = 140/575 (24%), Positives = 249/575 (43%), Gaps = 41/575 (7%)
Query: 266 GDVHYHLESHPPG-PFEVN-AEGNLYVTRELDREAQAEYLLQVRAQNSH-GEDYAAPLEL 322
G + Y L G F ++ G+++ + LDRE +A+Y L+ +A + G E
Sbjct: 92 GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEF 151
Query: 323 HVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNS-HVVYQLLSPE 381
+ + D NDN P ++PE+SP GT V +++A DAD P NS VVY +L +
Sbjct: 152 IIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQ 211
Query: 382 PEDGVEGRAFQVDPTSGSVTLGVLPL--RAGQNILLLVLAMDLAGAEGGFSSTCEVEVAV 439
P F VD +G + ++ + A + +++ A D+ G GG + T V + +
Sbjct: 212 P-------YFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITL 264
Query: 440 TDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTF 499
+D+ND+ P F +S+ E + V + A D D E M + I GD F
Sbjct: 265 SDVNDNPPRFPQKHY-QMSVLESAPISSTVGRVFAKDLD-EGINAEMKYTIVDGDGADAF 322
Query: 500 GLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQS---VAKLVGPGPGPGATATVTVLVE 556
+ +P+ + + K LS+E+ S+ + V + + + GP T TV + VE
Sbjct: 323 DISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQD-TTTVHISVE 381
Query: 557 RVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDP--ISRTLRFSLVNDSE--GWLCIEK 612
V PP + Y VP G+ + I DP + ++R+S+ S+ + ++
Sbjct: 382 DVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDI 441
Query: 613 FSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFL----KAPPAPALTLA 668
+G + TA+ L + + + V A + + P S P+ I L AP P A
Sbjct: 442 TTGALMTARPLD-REEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEA 500
Query: 669 PVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYL 728
++C + LI + + D D + ++L P ++ ++ + A +
Sbjct: 501 -----FVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARI 555
Query: 729 TLALHWVEPREHII---PVVVSHNAQ---MWQLLVRVIVCRCNVEGQCMRKVGRMKGMPT 782
+E + P++++ + Q + + VC C+ +G M +P
Sbjct: 556 LTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPV 615
Query: 783 KLSAVGILVGTLVAIGIFLILIFTHWTMSR-KKDP 816
LS G L+ L I + L+L+ +M R +K P
Sbjct: 616 SLSR-GALIAILACIFVLLVLVLLILSMRRHRKQP 649
Score = 116 bits (290), Expect = 1e-25
Identities = 122/484 (25%), Positives = 214/484 (44%), Gaps = 64/484 (13%)
Query: 29 VPENYGGNFPLYLTKLPLPREGAEGQI--VLSGDSGKATEGPFAMDPDSGFLLVTRALDR 86
V E Y G PLY+ KL + +G I +LSG+ F +D +G + + LDR
Sbjct: 68 VLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGIV---FTIDDTTGDIHAIQRLDR 124
Query: 87 EEQAEYQLQV-TLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPF 145
EE+A+Y L+ L+ + G + ++ ++D ND P F Y A + + G
Sbjct: 125 EERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSV 184
Query: 146 LFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALER 205
+ + A+D D+P NS + + Q QP F ++ + G + + ++D +
Sbjct: 185 IQVTATDADDPTYGNSARVVYSILQ--GQP---YFSVDSKTGVIRTA---LMNMDREAKE 236
Query: 206 TYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSG 265
Y++++Q KDMG Q G T TV +++ + V+ P + + A + +
Sbjct: 237 YYEVIIQAKDMGGQLGGLAGTTTVNITLSD---VNDNPPRFPQKHYQMSVLESAPISSTV 293
Query: 266 GDV--------------HYHLESHPPGPFEVNAEGN-----LYVTRELDREAQAEYLLQV 306
G V + ++ F+++ + N + V + L E++ Y L+V
Sbjct: 294 GRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKV 353
Query: 307 RAQNSHGE-------DYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLS 359
N H E + +H+ V D D P+ P V +PE GT + +S
Sbjct: 354 EGANPHLEMRFLNLGPFQDTTTVHISVEDV-DEPPVFEPGFYFVEVPEDVAIGTTIQIIS 412
Query: 360 AEDADAPGSPNSHVVYQL-LSPEPEDGVEGRAFQVDPTSGSVTLGVLPLR----AGQNIL 414
A+D D N+ + Y + S +P GR F VD T+G++ + PL + NI
Sbjct: 413 AKDPDV---TNNSIRYSIDRSSDP-----GRFFYVDITTGAL-MTARPLDREEFSWHNIT 463
Query: 415 LLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTA 474
+L + M+ G + V + V D+ND+APEF + + E+ + G L+ ++A
Sbjct: 464 VLAMEMNNPSQVG----SVPVTIKVLDVNDNAPEF--PRFYEAFVCENAKAGQLIQTVSA 517
Query: 475 IDAD 478
+D D
Sbjct: 518 VDQD 521
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/217 (23%), Positives = 81/217 (37%), Gaps = 12/217 (5%)
Query: 18 PKAQPAELSVEVPENY--GGNFPLYLTKLP-LPREGAEGQIVLSGDSGKATEGPFAMDPD 74
P +P VEVPE+ G + K P + I S D G+ F +D
Sbjct: 387 PVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRF----FYVDIT 442
Query: 75 SGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRAR 134
+G L+ R LDREE + + + V + G PV + V D ND P F + Y A
Sbjct: 443 TGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPR-FYEAF 501
Query: 135 LSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPK 194
+ + G + A D+D+P + S AP + F + A
Sbjct: 502 VCENAKAGQLIQTVSAVDQDDPRNG----QHFYYSLAPEAANNPNFTIRDNQDNTARILT 557
Query: 195 GSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEV 231
+ + + L + + D G T T++V
Sbjct: 558 RRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQV 594
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 129 bits (325), Expect = 9e-30
Identities = 141/557 (25%), Positives = 235/557 (42%), Gaps = 43/557 (7%)
Query: 272 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDEN 330
++ P F V + GNLY TR +DRE + + A G PL L + + DEN
Sbjct: 178 VDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDEN 237
Query: 331 DNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRA 390
DN PI T +I E GT V ++ A D D P + ++ + Y ++ P
Sbjct: 238 DNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPT---L 294
Query: 391 FQVDPTSGSVTL--GVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPE 448
F + PT+G +T L L + D+ G G +T + + D+NDH P
Sbjct: 295 FSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT 354
Query: 449 FITSQIGPISLPEDVEPGTL---VAMLTAIDADL-EPAFRLMDFAIERGDTEGTFGLDWE 504
F + S VE T+ + +T D DL A ++ I +G+ G F + +
Sbjct: 355 FTRT-----SYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTD 409
Query: 505 PDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGA--TATVTVLVERVMPPP 562
+ L + K L+YE + + V + A A TATVTV VE P
Sbjct: 410 AKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGP 469
Query: 563 KLDQESYEASVPISAPAGSFLLTIQPSDPISRT---LRFSLVNDSEGWLCIEKFSGEVHT 619
+ + + +A G+ + DP +R+ +R+ + D GW+ I++ +G +
Sbjct: 470 ECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKV 529
Query: 620 AQSLQGAQP---GDTYTVLVEAQDTDEPRLSASAPLVIHFLK--APPAPALTLAPVPSQY 674
+SL Y + V A D + + +++ + +P P T+
Sbjct: 530 FRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVI------ 583
Query: 675 LCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPT-VQRDWRLQTLNGSHAYLTLALH 733
+C P IV+ DPD P+ F+L + + VQR WRL+ +N + A L+ +
Sbjct: 584 ICKPTMSSAEIVA---VDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLS---Y 637
Query: 734 WVEP--REHIIPVVVSHNAQMWQLL-VRVIVCRCNVEGQCMRKVG-RMKGMPTKLSAVGI 789
+P +++P+ V M + + V +C C E C +V R+ G +L I
Sbjct: 638 QNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAI 697
Query: 790 LVGTLVAIGIFLILIFT 806
L L+ I + ++FT
Sbjct: 698 L-AILLGIALLFCILFT 713
Score = 120 bits (301), Expect = 5e-27
Identities = 129/512 (25%), Positives = 225/512 (43%), Gaps = 61/512 (11%)
Query: 19 KAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGP----FAMDPD 74
K + A + + EN G FPL+L ++ + A+ + G + F ++ D
Sbjct: 134 KRRWAPIPCSMLENSLGPFPLFLQQVQ--SDTAQNYTIYYSIRGPGVDQEPRNLFYVERD 191
Query: 75 SGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRAR 134
+G L TR +DRE+ +++ DG+ P P+++ ++DEND P F++ Y
Sbjct: 192 TGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFT 251
Query: 135 LSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPK 194
+ R G + A+D+DEP T ++ L++ I+ Q P PSP +F + P G + +
Sbjct: 252 IFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVP--PSPTLFSMHPTTGVITTT-- 307
Query: 195 GSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSI------------------IES 236
S+ LD L YQL ++V+DM Q G Q T+T ++I +E
Sbjct: 308 -SSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEE 366
Query: 237 TWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEV-----NAEGNLYVT 291
V +E + + K L + +W + L+ + G F++ EG L V
Sbjct: 367 NTVDVEILRVTVEDKDL----VNTANWRAN--YTILKGNENGNFKIVTDAKTNEGVLCVV 420
Query: 292 RELDREAQAEYLLQVRAQNS-----HGEDYAAPLELHVLV-MDENDNVPICPPRDPTVSI 345
+ L+ E + + +LQ+ N +A V V +++ D P C P TV +
Sbjct: 421 KPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRM 480
Query: 346 PELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVL 405
E + GT A D + S S + Y+ L+ +P V +D +GS+ +
Sbjct: 481 KENAEVGTTSNGYKAYDPETRSS--SGIRYKKLT-DPTGWV-----TIDENTGSIKVFRS 532
Query: 406 PLRAGQNILLLVLAMD-LAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVE 464
R + I + + LA +GG + T + + + D+ND++P FI + I +
Sbjct: 533 LDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSP-FIPKKTVII-----CK 586
Query: 465 PGTLVAMLTAIDADLEPAFRLMDFAIERGDTE 496
P A + A+D D DF++E +E
Sbjct: 587 PTMSSAEIVAVDPDEPIHGPPFDFSLESSTSE 618
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,897,789
Number of Sequences: 37866
Number of extensions: 1933165
Number of successful extensions: 9936
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 5670
Number of HSP's gapped (non-prelim): 1313
length of query: 829
length of database: 18,247,518
effective HSP length: 111
effective length of query: 718
effective length of database: 14,044,392
effective search space: 10083873456
effective search space used: 10083873456
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.