BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4757734 absent in melanoma 2 [Homo sapiens] (343 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4757734 absent in melanoma 2 [Homo sapiens] 665 0.0 gi|4505227 myeloid cell nuclear differentiation antigen [Homo sa... 186 3e-47 gi|112789562 interferon, gamma-inducible protein 16 [Homo sapiens] 183 2e-46 gi|41282051 pyrin and HIN domain family, member 1 beta 2 isoform... 172 4e-43 gi|41282048 pyrin and HIN domain family, member 1 alpha 2 isofor... 172 4e-43 gi|41282056 pyrin and HIN domain family, member 1 beta 1 isoform... 171 7e-43 gi|39540514 pyrin and HIN domain family, member 1 alpha 1 isofor... 171 7e-43 gi|4557743 Mediterranean fever protein [Homo sapiens] 37 0.026 gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 35 0.075 gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 35 0.13 gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 35 0.13 gi|110349721 titin isoform novex-3 [Homo sapiens] 34 0.22 gi|110349719 titin isoform N2-A [Homo sapiens] 34 0.22 gi|100814339 coiled-coil domain containing 146 [Homo sapiens] 32 0.63 gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 32 0.83 gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Hom... 32 1.1 gi|157694524 plexin D1 [Homo sapiens] 32 1.1 gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 32 1.1 gi|19557702 surfeit 6 [Homo sapiens] 32 1.1 gi|169162310 PREDICTED: similar to hCG2041495 [Homo sapiens] 31 1.4 gi|169161845 PREDICTED: similar to hCG2041495 [Homo sapiens] 31 1.4 gi|169162679 PREDICTED: hypothetical protein LOC646377 [Homo sap... 31 1.4 gi|5032223 plexin C1 [Homo sapiens] 31 1.8 gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 30 2.4 gi|7656983 TP53-target gene 5 protein [Homo sapiens] 30 2.4 gi|193788632 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform... 30 2.4 gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 30 2.4 gi|104526627 triadin [Homo sapiens] 30 2.4 gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo... 30 4.1 gi|109255234 centrosomal protein 290kDa [Homo sapiens] 30 4.1 >gi|4757734 absent in melanoma 2 [Homo sapiens] Length = 343 Score = 665 bits (1715), Expect = 0.0 Identities = 343/343 (100%), Positives = 343/343 (100%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS Sbjct: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 Query: 61 AVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAK 120 AVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAK Sbjct: 61 AVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAK 120 Query: 121 QRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHAT 180 QRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHAT Sbjct: 121 QRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHAT 180 Query: 181 VATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPL 240 VATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPL Sbjct: 181 VATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPL 240 Query: 241 NIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNED 300 NIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNED Sbjct: 241 NIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNED 300 Query: 301 TMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT 343 TMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT Sbjct: 301 TMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT 343 >gi|4505227 myeloid cell nuclear differentiation antigen [Homo sapiens] Length = 407 Score = 186 bits (471), Expect = 3e-47 Identities = 134/400 (33%), Positives = 200/400 (50%), Gaps = 61/400 (15%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 M ++YK+ILLL G + + D K L+ + + T NRI++ LM + V+ Sbjct: 1 MVNEYKKILLLKGFELMDDYHFTSIKSLLAYDLGLTTKMQEEYNRIKITDLMEKKFQGVA 60 Query: 61 AVMKTIRIFQKLNYML-LAKRLQEEKEKVDKQYKSVTKP--KPLSQAEMSPAASA----- 112 + K I + + + + L L++EK KV K+ K+ K K ++Q E+ AA A Sbjct: 61 CLDKLIELAKDMPSLKNLVNNLRKEKSKVAKKIKTQEKAPVKKINQEEVGLAAPAPTARN 120 Query: 113 -------------------------AIRNDVAKQRAAPK--------------------- 126 A RN V+++++ P Sbjct: 121 KLTSEARGRIPVAQKRKTPNKEKTEAKRNKVSQEQSKPPGPSGASTSAAVDHPPLPQTSS 180 Query: 127 ---VSPHVKPEQKQMVAQQESIREGF-QKRCLPVMVLKAKKPFTFETQE-GKQEMFHATV 181 + P Q+ +Q R Q + V+VLKA PF +E+ E GK MFHATV Sbjct: 181 STPSNTSFTPNQETQAQRQVDARRNVPQNDPVTVVVLKATAPFKYESPENGKSTMFHATV 240 Query: 182 ATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLN 241 A++ ++F VKVF+ LK+KF+ K++I I+ Y G +E+ AS V D +Q VP Sbjct: 241 ASKTQYFHVKVFDINLKEKFVRKKVITISDYSECKGVMEIKEASSVSDF--NQNFEVPNR 298 Query: 242 IIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDT 301 II A +TPKI+ L Q GT+V GLF++QK + KKN ++++ DNTG M+V+G Sbjct: 299 IIEIANKTPKISQLYKQASGTMVYGLFMLQKKSVHKKNTIYEIQDNTGSMDVVGSGKWHN 358 Query: 302 MKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKK 341 +KC++GDK+RL L KL+L G HS IKVIKAKK Sbjct: 359 IKCEKGDKLRLFCLQLRTVDRKLKLVCGSHSFIKVIKAKK 398 >gi|112789562 interferon, gamma-inducible protein 16 [Homo sapiens] Length = 729 Score = 183 bits (465), Expect = 2e-46 Identities = 135/396 (34%), Positives = 197/396 (49%), Gaps = 57/396 (14%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 M KYK I+LL GL+ I D K LS++ + ++IQ+A LM + + Sbjct: 1 MGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKFRGDA 60 Query: 61 AVMKTIRIFQKLNYML-LAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVA 119 + K I+IF+ + + LA+ L++EK KV S + K + +P+ S+ ++ + A Sbjct: 61 GLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVKTEGA 120 Query: 120 -------------KQRAAPKVSPHVKPEQKQMVA-------------------------- 140 K++A PK S V EQ Q + Sbjct: 121 EATPGAQKRKKSTKEKAGPKGSK-VSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAPPNS 179 Query: 141 ------------QQESIREGFQKRCLPVMVLKAKKPFTFETQE-GKQEMFHATVATEKEF 187 Q R QKR + V VL KPF +ET E K+ MFHATVAT+ +F Sbjct: 180 SSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQTQF 239 Query: 188 FFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAG 247 F VKV NT LK+KF K+IIII+ Y + LEVN S V +A +Q VP II +A Sbjct: 240 FHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIINRAK 299 Query: 248 ETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEG 307 ET KI+ L Q G IV G+F++ K T +K ++++ D+ GKM+V+G + C+EG Sbjct: 300 ETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPCEEG 359 Query: 308 DKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT 343 DK++L F L K + +L S +HS I++ KKKT Sbjct: 360 DKLQLFCFRLRKKNQMSKLISEMHSFIQI---KKKT 392 Score = 168 bits (426), Expect = 6e-42 Identities = 98/216 (45%), Positives = 135/216 (62%), Gaps = 7/216 (3%) Query: 127 VSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKE 186 + P +K E +++ SI + Q VMVL A + F +E +E K+ MFHATVATE E Sbjct: 500 LKPRLKTEPEEV-----SIEDSAQSDLKEVMVLNATESFVYEPKEQKK-MFHATVATENE 553 Query: 187 FFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKA 246 F VKVFN LK+KF PK+II IA Y +GFLEV + V D +D+ + +P +IR A Sbjct: 554 VFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSA 613 Query: 247 GETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKE 306 TPKIN L +Q G+ VNG+F V K + + +++ DNTGKMEV+ T+ C+E Sbjct: 614 SVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEE 673 Query: 307 GDKVRLTFFTLS-KNGEKLQLTSGVHSTIKVIKAKK 341 GDK++LT F L+ K+G +L S +HS IKVIK +K Sbjct: 674 GDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRK 709 >gi|41282051 pyrin and HIN domain family, member 1 beta 2 isoform [Homo sapiens] Length = 452 Score = 172 bits (436), Expect = 4e-43 Identities = 125/391 (31%), Positives = 189/391 (48%), Gaps = 53/391 (13%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 M + YK+I+LL GL+ I D K LS++ + ++IQ+A LM + + Sbjct: 1 MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDA 60 Query: 61 AVMKTIRIFQKLNYM----------------------------------------LLAKR 80 + K I F+++ + L AK Sbjct: 61 GLGKLIEFFKEIPTLGDLAETLKREKLKVKGIIPSKKTKQKEVYPATPACTPSNRLTAKG 120 Query: 81 LQE----EKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKP--- 133 +E +K K + ++ TK +S+ + P+ SA A R+ P + P Sbjct: 121 AEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQTSSSAPPNT 180 Query: 134 ---EQKQMVAQQESI--REGFQKRCLPVMVLKAKKPFTFETQEGKQE-MFHATVATEKEF 187 E + +A + + + F++ + MVL A K F +E+ E +Q MFHATVAT+ +F Sbjct: 181 SSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQF 240 Query: 188 FFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAG 247 F VKV N LK KFI KRIIII+ Y + + LEVN AS V +A DQ VP +IIR+A Sbjct: 241 FHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAK 300 Query: 248 ETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEG 307 + PKIN L Q G IV GLF++ +K ++++ D TG M V+G + C++G Sbjct: 301 KIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKG 360 Query: 308 DKVRLTFFTLSKNGEKLQLTSGVHSTIKVIK 338 DK+RL F L K +L S +HS I++ K Sbjct: 361 DKLRLFCFRLRKRENMSKLMSEMHSFIQIQK 391 >gi|41282048 pyrin and HIN domain family, member 1 alpha 2 isoform [Homo sapiens] Length = 483 Score = 172 bits (436), Expect = 4e-43 Identities = 125/391 (31%), Positives = 189/391 (48%), Gaps = 53/391 (13%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 M + YK+I+LL GL+ I D K LS++ + ++IQ+A LM + + Sbjct: 1 MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDA 60 Query: 61 AVMKTIRIFQKLNYM----------------------------------------LLAKR 80 + K I F+++ + L AK Sbjct: 61 GLGKLIEFFKEIPTLGDLAETLKREKLKVKGIIPSKKTKQKEVYPATPACTPSNRLTAKG 120 Query: 81 LQE----EKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKP--- 133 +E +K K + ++ TK +S+ + P+ SA A R+ P + P Sbjct: 121 AEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQTSSSAPPNT 180 Query: 134 ---EQKQMVAQQESI--REGFQKRCLPVMVLKAKKPFTFETQEGKQE-MFHATVATEKEF 187 E + +A + + + F++ + MVL A K F +E+ E +Q MFHATVAT+ +F Sbjct: 181 SSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQF 240 Query: 188 FFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAG 247 F VKV N LK KFI KRIIII+ Y + + LEVN AS V +A DQ VP +IIR+A Sbjct: 241 FHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAK 300 Query: 248 ETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEG 307 + PKIN L Q G IV GLF++ +K ++++ D TG M V+G + C++G Sbjct: 301 KIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKG 360 Query: 308 DKVRLTFFTLSKNGEKLQLTSGVHSTIKVIK 338 DK+RL F L K +L S +HS I++ K Sbjct: 361 DKLRLFCFRLRKRENMSKLMSEMHSFIQIQK 391 >gi|41282056 pyrin and HIN domain family, member 1 beta 1 isoform [Homo sapiens] Length = 461 Score = 171 bits (434), Expect = 7e-43 Identities = 127/400 (31%), Positives = 191/400 (47%), Gaps = 62/400 (15%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 M + YK+I+LL GL+ I D K LS++ + ++IQ+A LM + + Sbjct: 1 MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDA 60 Query: 61 AVMKTIRIFQKLNYML-LAKRLQEEKEKVDKQYKSV------------------------ 95 + K I F+++ + LA+ L+ EK KV + +S+ Sbjct: 61 GLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPATPACT 120 Query: 96 ----------------------------TKPKPLSQAEMSPAASAAIRNDVAKQRAAPKV 127 TK +S+ + P+ SA A R+ P Sbjct: 121 PSNRLTAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQ 180 Query: 128 SPHVKP------EQKQMVAQQESI--REGFQKRCLPVMVLKAKKPFTFETQEGKQE-MFH 178 + P E + +A + + + F++ + MVL A K F +E+ E +Q MFH Sbjct: 181 TSSSAPPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFH 240 Query: 179 ATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNV 238 ATVAT+ +FF VKV N LK KFI KRIIII+ Y + + LEVN AS V +A DQ V Sbjct: 241 ATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEV 300 Query: 239 PLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRN 298 P +IIR+A + PKIN L Q G IV GLF++ +K ++++ D TG M V+G Sbjct: 301 PKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGE 360 Query: 299 EDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIK 338 + C++GDK+RL F L K +L S +HS I++ K Sbjct: 361 CHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQK 400 >gi|39540514 pyrin and HIN domain family, member 1 alpha 1 isoform [Homo sapiens] Length = 492 Score = 171 bits (434), Expect = 7e-43 Identities = 127/400 (31%), Positives = 191/400 (47%), Gaps = 62/400 (15%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 M + YK+I+LL GL+ I D K LS++ + ++IQ+A LM + + Sbjct: 1 MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDA 60 Query: 61 AVMKTIRIFQKLNYML-LAKRLQEEKEKVDKQYKSV------------------------ 95 + K I F+++ + LA+ L+ EK KV + +S+ Sbjct: 61 GLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPATPACT 120 Query: 96 ----------------------------TKPKPLSQAEMSPAASAAIRNDVAKQRAAPKV 127 TK +S+ + P+ SA A R+ P Sbjct: 121 PSNRLTAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQ 180 Query: 128 SPHVKP------EQKQMVAQQESI--REGFQKRCLPVMVLKAKKPFTFETQEGKQE-MFH 178 + P E + +A + + + F++ + MVL A K F +E+ E +Q MFH Sbjct: 181 TSSSAPPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFH 240 Query: 179 ATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNV 238 ATVAT+ +FF VKV N LK KFI KRIIII+ Y + + LEVN AS V +A DQ V Sbjct: 241 ATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEV 300 Query: 239 PLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRN 298 P +IIR+A + PKIN L Q G IV GLF++ +K ++++ D TG M V+G Sbjct: 301 PKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGE 360 Query: 299 EDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIK 338 + C++GDK+RL F L K +L S +HS I++ K Sbjct: 361 CHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQK 400 >gi|4557743 Mediterranean fever protein [Homo sapiens] Length = 781 Score = 37.0 bits (84), Expect = 0.026 Identities = 21/78 (26%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 10 LLTGLDNITDEELDRFKFFLS------DEFNIATGKLHTANRIQVATLMIQNAGAVSAVM 63 LL+ L+ + + ++FKF L + I ++ A +++ATL++ G AV Sbjct: 9 LLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGEEYAVQ 68 Query: 64 KTIRIFQKLNYMLLAKRL 81 T+++ + +N LLA+ L Sbjct: 69 LTLQVLRAINQRLLAEEL 86 >gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] Length = 1093 Score = 35.4 bits (80), Expect = 0.075 Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 5/87 (5%) Query: 3 SKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATG-----KLHTANRIQVATLMIQNAG 57 S + + LL L+ + EEL+ FK FL + G ++ A R +A LM + Sbjct: 8 SFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYP 67 Query: 58 AVSAVMKTIRIFQKLNYMLLAKRLQEE 84 A +++IF K+N L +R +EE Sbjct: 68 GEKAWSVSLKIFGKMNLKDLCERAKEE 94 >gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] Length = 1062 Score = 34.7 bits (78), Expect = 0.13 Identities = 23/96 (23%), Positives = 53/96 (55%), Gaps = 10/96 (10%) Query: 14 LDNITDEELDRFKFFLSDEFNIATG-------KLHTANRIQVATLMIQNAGAVSAVMKTI 66 L+ ++ +EL +FK+ ++ F++A ++ A+ Q+ ++ + + M ++ Sbjct: 15 LEQLSQDELSKFKYLITT-FSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEMASL 73 Query: 67 RIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLS 102 ++F+K++ M L++R ++E + KS K KPLS Sbjct: 74 QVFEKMHRMDLSERAKDEVR--EAALKSFNKRKPLS 107 >gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] Length = 994 Score = 34.7 bits (78), Expect = 0.13 Identities = 27/103 (26%), Positives = 49/103 (47%), Gaps = 6/103 (5%) Query: 3 SKYKEILLLTGLDNITDEELDRFKFFLSDEF------NIATGKLHTANRIQVATLMIQNA 56 S + + L+ L+ + EE +FK L I ++ A+R ++A L+I++ Sbjct: 4 SFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHY 63 Query: 57 GAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPK 99 A T+RIFQK++ L ++ E+ K Y++ K K Sbjct: 64 EEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQK 106 >gi|110349721 titin isoform novex-3 [Homo sapiens] Length = 5604 Score = 33.9 bits (76), Expect = 0.22 Identities = 47/214 (21%), Positives = 84/214 (39%), Gaps = 10/214 (4%) Query: 42 TANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPL 101 TA IQ A ++ +AV K + K L R +E +Q VT + Sbjct: 456 TAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMH-VTHEQIR 514 Query: 102 SQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKA 161 + E + I AK++ ++S + +QKQ+ QE+IR+ + ++V+ Sbjct: 515 KETEKTFVPKVVISAAKAKEQET-RISEEITKKQKQVT--QEAIRQETEITAASMVVVAT 571 Query: 162 KKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEV 221 K ET G QE T + + K+ K +PK I+ + ++ Sbjct: 572 AKSTKLETVPGAQEE-TTTQQDQMHLSYEKIMKETRK-TVVPKVIVATPKVKEQ----DL 625 Query: 222 NSASRVLDAESDQKVNVPLNIIRKAGETPKINTL 255 S R ++V + +RK E ++T+ Sbjct: 626 VSRGREGITTKREQVQITQEKMRKEAEKTALSTI 659 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 33.9 bits (76), Expect = 0.22 Identities = 47/214 (21%), Positives = 84/214 (39%), Gaps = 10/214 (4%) Query: 42 TANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPL 101 TA IQ A ++ +AV K + K L R +E +Q VT + Sbjct: 456 TAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMH-VTHEQIR 514 Query: 102 SQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKA 161 + E + I AK++ ++S + +QKQ+ QE+IR+ + ++V+ Sbjct: 515 KETEKTFVPKVVISAAKAKEQET-RISEEITKKQKQVT--QEAIRQETEITAASMVVVAT 571 Query: 162 KKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEV 221 K ET G QE T + + K+ K +PK I+ + ++ Sbjct: 572 AKSTKLETVPGAQEE-TTTQQDQMHLSYEKIMKETRK-TVVPKVIVATPKVKEQ----DL 625 Query: 222 NSASRVLDAESDQKVNVPLNIIRKAGETPKINTL 255 S R ++V + +RK E ++T+ Sbjct: 626 VSRGREGITTKREQVQITQEKMRKEAEKTALSTI 659 >gi|100814339 coiled-coil domain containing 146 [Homo sapiens] Length = 955 Score = 32.3 bits (72), Expect = 0.63 Identities = 45/211 (21%), Positives = 93/211 (44%), Gaps = 28/211 (13%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVS 60 M ++ E+ LL T E++ + +F L N ++++ L QN + Sbjct: 79 MSTQESEVQLLQNAKRFT-EQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNE--YN 135 Query: 61 AVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPL-SQAEMSPAASAAIRNDVA 119 AV + ++ + L+EEK + K+++ +TKP + + ++ ++ +R ++ Sbjct: 136 AVKE-----REFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIM 190 Query: 120 KQRAAPK-VSPHVKPEQKQMVAQQESIRE--GFQ---------KRCLPVMVLKAKKPFTF 167 +++ K + + +QKQ++ +Q+ + E G Q + +PV + K + T Sbjct: 191 QKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKIT- 249 Query: 168 ETQEGKQEMFHATVATEKEFFFVKVFNTLLK 198 K EM + E+E VK N LK Sbjct: 250 ---RKKVEMEKKKIVLEQE---VKTLNDSLK 274 >gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo sapiens] Length = 1061 Score = 32.0 bits (71), Expect = 0.83 Identities = 23/80 (28%), Positives = 38/80 (47%), Gaps = 5/80 (6%) Query: 10 LLTGLDNITDEELDRFKFFLS-----DEFNIATGKLHTANRIQVATLMIQNAGAVSAVMK 64 L T L+ + EL +FK +L E I G + A +++A L+I + G A Sbjct: 13 LSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRL 72 Query: 65 TIRIFQKLNYMLLAKRLQEE 84 + F+++N L +R Q E Sbjct: 73 ALSTFERINRKDLWERGQRE 92 >gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Homo sapiens] Length = 615 Score = 31.6 bits (70), Expect = 1.1 Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 4/81 (4%) Query: 216 SGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTE 275 S F +N V D ++ QK+ + + A +PK + T P G + + T Sbjct: 34 SVFTSLNKEKIVTDQQTGQKIQIVTAV--DASGSPKQQFILTSPDGAGTGKVILASPETS 91 Query: 276 KKKNILFDLSDN--TGKMEVL 294 K ++F SDN G+++++ Sbjct: 92 SAKQLIFTTSDNLVPGRIQIV 112 >gi|157694524 plexin D1 [Homo sapiens] Length = 1925 Score = 31.6 bits (70), Expect = 1.1 Identities = 20/75 (26%), Positives = 37/75 (49%), Gaps = 3/75 (4%) Query: 73 NYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMS---PAASAAIRNDVAKQRAAPKVSP 129 N +L AK + E ++ V + YK + PLS+ EM+ S +N+ A ++ Sbjct: 1820 NKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYK 1879 Query: 130 HVKPEQKQMVAQQES 144 + K + Q++A E+ Sbjct: 1880 YAKRYRPQIMAALEA 1894 >gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] Length = 892 Score = 31.6 bits (70), Expect = 1.1 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 4/81 (4%) Query: 9 LLLTGLDNITDEELDRFKFFL----SDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMK 64 LLL L+ ++ E+L RF+ L D +I G+L A+ + +A + Q G A+ Sbjct: 21 LLLAALEELSQEQLKRFRHKLRDVGPDGRSIPWGRLERADAVDLAEQLAQFYGPEPALEV 80 Query: 65 TIRIFQKLNYMLLAKRLQEEK 85 + ++ + +A +LQE + Sbjct: 81 ARKTLKRADARDVAAQLQERR 101 >gi|19557702 surfeit 6 [Homo sapiens] Length = 361 Score = 31.6 bits (70), Expect = 1.1 Identities = 17/46 (36%), Positives = 27/46 (58%) Query: 79 KRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAA 124 K+ ++ ++K K+ + + K S E SPAAS A R + AK+ AA Sbjct: 46 KKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAA 91 >gi|169162310 PREDICTED: similar to hCG2041495 [Homo sapiens] Length = 196 Score = 31.2 bits (69), Expect = 1.4 Identities = 17/52 (32%), Positives = 27/52 (51%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLM 52 M SKYK +LL GL+ I D L ++ + + + ++IQ+A LM Sbjct: 41 MVSKYKNNVLLKGLEAINDYHFSIINSLLINDLKLNSTRRDEYDKIQIADLM 92 >gi|169161845 PREDICTED: similar to hCG2041495 [Homo sapiens] Length = 196 Score = 31.2 bits (69), Expect = 1.4 Identities = 17/52 (32%), Positives = 27/52 (51%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLM 52 M SKYK +LL GL+ I D L ++ + + + ++IQ+A LM Sbjct: 41 MVSKYKNNVLLKGLEAINDYHFSIINSLLINDLKLNSTRRDEYDKIQIADLM 92 >gi|169162679 PREDICTED: hypothetical protein LOC646377 [Homo sapiens] Length = 196 Score = 31.2 bits (69), Expect = 1.4 Identities = 17/52 (32%), Positives = 27/52 (51%) Query: 1 MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLM 52 M SKYK +LL GL+ I D L ++ + + + ++IQ+A LM Sbjct: 41 MVSKYKNNVLLKGLEAINDYHFSIINSLLINDLKLNSTRRDEYDKIQIADLM 92 >gi|5032223 plexin C1 [Homo sapiens] Length = 1568 Score = 30.8 bits (68), Expect = 1.8 Identities = 27/96 (28%), Positives = 46/96 (47%), Gaps = 5/96 (5%) Query: 73 NYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMS---PAASAAIRNDVAKQRAAPKVSP 129 N +L AK + KE+V YK++ PLS +EM S N+ ++ A ++ Sbjct: 1467 NKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYK 1526 Query: 130 HVKPEQKQMVAQQESIR--EGFQKRCLPVMVLKAKK 163 ++ +++ + E R E QK+ L V VL +K Sbjct: 1527 YIVKYFDEILNKLERERGLEEAQKQLLHVKVLFDEK 1562 >gi|148806928 hypothetical protein LOC57482 [Homo sapiens] Length = 1233 Score = 30.4 bits (67), Expect = 2.4 Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 5/87 (5%) Query: 70 QKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSP 129 ++ NY L Q+ ++K K++ S A+ P A+ + R + + A K P Sbjct: 850 RRTNYSLRFNCDQQAEQKKKKRHSSTG-----DSADAGPPAAGSARGEKEMEGVALKHGP 904 Query: 130 HVKPEQKQMVAQQESIREGFQKRCLPV 156 + E+KQ + + E R +PV Sbjct: 905 SLPQERKQAPSTRRDSAEPSSSRSVPV 931 >gi|7656983 TP53-target gene 5 protein [Homo sapiens] Length = 290 Score = 30.4 bits (67), Expect = 2.4 Identities = 20/70 (28%), Positives = 32/70 (45%), Gaps = 2/70 (2%) Query: 84 EKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAA-PKVSPHVKPEQKQMVAQQ 142 EKE K+ +S PK E + +RN AA P+ H++PE + ++ Sbjct: 107 EKELKSKKLESTGDPKKKEYKEWKSQVQSGMRNKEKTSLAAMPRKEKHIEPEVPR-TSRD 165 Query: 143 ESIREGFQKR 152 +S+ G Q R Sbjct: 166 DSLNPGVQGR 175 >gi|193788632 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform 2 [Homo sapiens] Length = 568 Score = 30.4 bits (67), Expect = 2.4 Identities = 34/150 (22%), Positives = 64/150 (42%), Gaps = 16/150 (10%) Query: 36 ATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSV 95 A K NRI+ ++ NA + +K + +K AK+ E+K K + + K Sbjct: 256 AQRKKEEMNRIRT---LVDNAYSCDPRIKKFKEEEK------AKKEAEKKAKAEAKRKEQ 306 Query: 96 TKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLP 155 + QAE+ A +AK++ +V +K+ Q+++I++ QK Sbjct: 307 EAKEKQRQAELEAAR-------LAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNS 359 Query: 156 VMVLKAKKPFTFETQEGKQEMFHATVATEK 185 + + + E +E + M A+ TEK Sbjct: 360 CKIEEINEQIRKEKEEAEARMRQASKNTEK 389 >gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] Length = 1417 Score = 30.4 bits (67), Expect = 2.4 Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 6/78 (7%) Query: 71 KLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPH 130 K +L +L+ KEK +KQ K ++ Q E+ I+N ++ + V Sbjct: 855 KEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK------IKNHSLQETSEQNVILQ 908 Query: 131 VKPEQKQMVAQQESIREG 148 +Q+Q + QQE+IR G Sbjct: 909 HTLQQQQQMLQQETIRNG 926 >gi|104526627 triadin [Homo sapiens] Length = 729 Score = 30.4 bits (67), Expect = 2.4 Identities = 23/67 (34%), Positives = 36/67 (53%), Gaps = 9/67 (13%) Query: 85 KEKVDKQYKSVT-----KPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHV--KPEQKQ 137 +EKV KQ K+VT KPKP +AE +I+ D K + PK + V ++K Sbjct: 558 EEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTD--KPKPTPKGTSEVTESGKKKT 615 Query: 138 MVAQQES 144 ++++ES Sbjct: 616 EISEKES 622 >gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo sapiens] Length = 1483 Score = 29.6 bits (65), Expect = 4.1 Identities = 33/160 (20%), Positives = 68/160 (42%), Gaps = 25/160 (15%) Query: 20 EELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAK 79 E+L+ +FF +L + ++Q+ T + +V + Q+++ L + Sbjct: 730 EKLETSEFF----------ELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKE 779 Query: 80 RLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAK---QRAAPKVSPHVKPEQK 136 RL KE+ DK+ K K + E + + N + K ++ K P V E + Sbjct: 780 RLAVLKEENDKKRAEKQKRK---EMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAE 836 Query: 137 QMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEM 176 M++ +S R ++ ++AKK + +E K ++ Sbjct: 837 DMISAVKSRR---------LLAIQAKKEREIQEREMKVKL 867 >gi|109255234 centrosomal protein 290kDa [Homo sapiens] Length = 2479 Score = 29.6 bits (65), Expect = 4.1 Identities = 19/75 (25%), Positives = 37/75 (49%) Query: 77 LAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQK 136 L +RL+ + +KQ K++++ +AEM+ AA I + +++ A V V + Sbjct: 1726 LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTR 1785 Query: 137 QMVAQQESIREGFQK 151 ++ Q E + E K Sbjct: 1786 ELKTQVEDLNENLLK 1800 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.132 0.356 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,026,312 Number of Sequences: 37866 Number of extensions: 447531 Number of successful extensions: 1828 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 24 Number of HSP's successfully gapped in prelim test: 32 Number of HSP's that attempted gapping in prelim test: 1772 Number of HSP's gapped (non-prelim): 84 length of query: 343 length of database: 18,247,518 effective HSP length: 103 effective length of query: 240 effective length of database: 14,347,320 effective search space: 3443356800 effective search space used: 3443356800 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.