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Search of human proteins with 47132585
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47132585 cAMP-dependent protein kinase, regulatory subunit
beta 2 [Homo sapiens]
(418 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47132585 cAMP-dependent protein kinase, regulatory subunit be... 836 0.0
gi|4758958 cAMP-dependent protein kinase, regulatory subunit alp... 527 e-150
gi|38257139 protein kinase, cAMP-dependent, regulatory, type I, ... 249 4e-66
gi|47132583 cAMP-dependent protein kinase, regulatory subunit al... 234 1e-61
gi|47132581 cAMP-dependent protein kinase, regulatory subunit al... 234 1e-61
gi|4506063 cAMP-dependent protein kinase, regulatory subunit alp... 234 1e-61
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 135 9e-32
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 130 2e-30
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 125 5e-29
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 49 1e-05
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 49 1e-05
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 49 1e-05
gi|116256487 patatin-like phospholipase domain containing 6 [Hom... 47 3e-05
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 47 4e-05
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 47 4e-05
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 45 2e-04
gi|148727335 patatin-like phospholipase domain containing 7 isof... 44 3e-04
gi|148727290 patatin-like phospholipase domain containing 7 isof... 44 3e-04
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 42 0.001
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 42 0.001
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 38 0.015
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 38 0.020
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 38 0.020
gi|8394343 sperm autoantigenic protein 17 [Homo sapiens] 37 0.033
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 36 0.057
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 36 0.057
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 36 0.074
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 35 0.097
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 35 0.13
gi|156938257 leucine rich repeat containing 16B [Homo sapiens] 35 0.17
>gi|47132585 cAMP-dependent protein kinase, regulatory subunit beta
2 [Homo sapiens]
Length = 418
Score = 836 bits (2160), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 1 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD 60
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD
Sbjct: 1 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD 60
Query: 61 LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY 120
LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY
Sbjct: 61 LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY 120
Query: 121 NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH 180
NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH
Sbjct: 121 NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH 180
Query: 181 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS 240
VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS
Sbjct: 181 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS 240
Query: 241 PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG 300
PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG
Sbjct: 241 PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG 300
Query: 301 EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP 360
EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP
Sbjct: 301 EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP 360
Query: 361 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 418
RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
Sbjct: 361 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 418
>gi|4758958 cAMP-dependent protein kinase, regulatory subunit alpha
2 [Homo sapiens]
Length = 404
Score = 527 bits (1357), Expect = e-150
Identities = 274/412 (66%), Positives = 322/412 (78%), Gaps = 17/412 (4%)
Query: 3 IEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLG 62
I+IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL++ AR
Sbjct: 4 IQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLRE-------ARAPASVLPAATPR 56
Query: 63 AAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNP 122
+ G P G + + + DSE E+E+ PV +RF RR SVCAE YNP
Sbjct: 57 QSLGHPPPEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAETYNP 107
Query: 123 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVI 182
DEEE+D + R+IHPKTD+QR RLQEACKDILLFKNLD EQ+SQVLDAMFE++VK EHVI
Sbjct: 108 DEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVI 167
Query: 183 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPG 242
DQGDDGDNFYVI+RGT+DI V D R VG YDNRGSFGELALMYNTPRAATI ATS G
Sbjct: 168 DQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEG 227
Query: 243 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQ 302
+LWGLDRVTFRRIIVKNNAKKRKM+ESFIES+P LKSLE SER+K+VDVIG K+Y DGE+
Sbjct: 228 SLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGER 287
Query: 303 IIAQGDSADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYFGELALVTNKPR 361
II QG+ ADSF+I+ESGEV I ++ + KS + N VEIARC +GQYFGELALVTNKPR
Sbjct: 288 IITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPR 347
Query: 362 AASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI 413
AASA+A+G VKCL MDVQAFERLLGPCM+IMKRNI+ YEEQLV +FG+++D+
Sbjct: 348 AASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDL 399
>gi|38257139 protein kinase, cAMP-dependent, regulatory, type I,
beta [Homo sapiens]
Length = 381
Score = 249 bits (635), Expect = 4e-66
Identities = 151/394 (38%), Positives = 211/394 (53%), Gaps = 48/394 (12%)
Query: 8 GLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGG 67
G+ ++L+ V + +P ++F +HF +L++E R+ AR
Sbjct: 26 GIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILAR----------------- 68
Query: 68 GTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEED 127
+ QSDS D EE +P PV+ RR V AE Y E+
Sbjct: 69 ---------QKSNSQSDSHD---EEVSPTPPN----PVVKARRRRGGVSAEVYT----EE 108
Query: 128 DAES--RIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQG 185
DA S R + PK L +A +LF +LD + S + DAMF GE VI QG
Sbjct: 109 DAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQG 168
Query: 186 DDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALW 245
++GDNFYV+D+G D+YV G V N GSFGELAL+Y TPRAAT+ A + LW
Sbjct: 169 NEGDNFYVVDQGEVDVYVN----GEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLW 224
Query: 246 GLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIA 305
G+DR ++RRI++ + +KRKMYE F+ + L+SLE ERL V D + + DGE+I+
Sbjct: 225 GIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVV 284
Query: 306 QGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASA 365
QG+ D F+I+ G + +R E VE+ R YFGE+AL+ N+PRAA+
Sbjct: 285 QGEPGDDFYIITEGTASVLQRRSPNEEY-----VEVGRLGPSDYFGEIALLLNRPRAATV 339
Query: 366 HAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 399
A G +KC+ +D FER+LGPC EI+KRNI Y
Sbjct: 340 VARGPLKCVKLDRPRFERVLGPCSEILKRNIQRY 373
>gi|47132583 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 234 bits (596), Expect = 1e-61
Identities = 134/315 (42%), Positives = 185/315 (58%), Gaps = 19/315 (6%)
Query: 87 DGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNR 144
D E+E +P PV+ RR ++ AE Y E+DA S R + PK
Sbjct: 76 DSREDEISPPPPN----PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAA 127
Query: 145 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVK 204
L +A + +LF +LD + S + DAMF GE VI QGD+GDNFYVID+G D+YV
Sbjct: 128 LAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVN 187
Query: 205 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKR 264
+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KR
Sbjct: 188 ----NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
Query: 265 KMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKIT 324
KMYE F+ + L+SL+ ERL V D + + DG++I+ QG+ D FFI+ G +
Sbjct: 244 KMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVL 303
Query: 325 MKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 384
+R SE EE VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 304 QRR---SENEE--FVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
Query: 385 LGPCMEIMKRNIATY 399
LGPC +I+KRNI Y
Sbjct: 359 LGPCSDILKRNIQQY 373
>gi|47132581 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 234 bits (596), Expect = 1e-61
Identities = 134/315 (42%), Positives = 185/315 (58%), Gaps = 19/315 (6%)
Query: 87 DGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNR 144
D E+E +P PV+ RR ++ AE Y E+DA S R + PK
Sbjct: 76 DSREDEISPPPPN----PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAA 127
Query: 145 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVK 204
L +A + +LF +LD + S + DAMF GE VI QGD+GDNFYVID+G D+YV
Sbjct: 128 LAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVN 187
Query: 205 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKR 264
+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KR
Sbjct: 188 ----NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
Query: 265 KMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKIT 324
KMYE F+ + L+SL+ ERL V D + + DG++I+ QG+ D FFI+ G +
Sbjct: 244 KMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVL 303
Query: 325 MKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 384
+R SE EE VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 304 QRR---SENEE--FVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
Query: 385 LGPCMEIMKRNIATY 399
LGPC +I+KRNI Y
Sbjct: 359 LGPCSDILKRNIQQY 373
>gi|4506063 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 234 bits (596), Expect = 1e-61
Identities = 134/315 (42%), Positives = 185/315 (58%), Gaps = 19/315 (6%)
Query: 87 DGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNR 144
D E+E +P PV+ RR ++ AE Y E+DA S R + PK
Sbjct: 76 DSREDEISPPPPN----PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAA 127
Query: 145 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVK 204
L +A + +LF +LD + S + DAMF GE VI QGD+GDNFYVID+G D+YV
Sbjct: 128 LAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVN 187
Query: 205 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKR 264
+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KR
Sbjct: 188 ----NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
Query: 265 KMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKIT 324
KMYE F+ + L+SL+ ERL V D + + DG++I+ QG+ D FFI+ G +
Sbjct: 244 KMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVL 303
Query: 325 MKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 384
+R SE EE VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 304 QRR---SENEE--FVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
Query: 385 LGPCMEIMKRNIATY 399
LGPC +I+KRNI Y
Sbjct: 359 LGPCSDILKRNIQQY 373
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 135 bits (339), Expect = 9e-32
Identities = 82/321 (25%), Positives = 163/321 (50%), Gaps = 17/321 (5%)
Query: 81 MQSDSEDGEEEEAAPADAGAFNAPVINRFTRR---ASVCAE----AYNPDEEEDDAESRI 133
MQ S + P + + +++ +RR A V AE Y+ ++ + + +
Sbjct: 88 MQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKA 147
Query: 134 IHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYV 193
K ++ + +A K LDP+Q+ +++ M+ + + G ++I QG+ G++ +V
Sbjct: 148 RVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFV 207
Query: 194 IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFR 253
+ G +++ + + + +FGELA++YN R A++ A + W LDR F+
Sbjct: 208 LAEGRLEVFQG----EKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQ 263
Query: 254 RIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSF 313
I+ + + + Y +F+ S+ LK+L + K++D + + Y+ G+ II +G+ +F
Sbjct: 264 NIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTF 323
Query: 314 FIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHA-IGTVK 372
FI+ G+VK+T +G + + I +G+YFGE AL+++ R+A+ A V
Sbjct: 324 FILAKGKVKVTQSTEGHDQPQ-----LIKTLQKGEYFGEKALISDDVRSANIIAEENDVA 378
Query: 373 CLAMDVQAFERLLGPCMEIMK 393
CL +D + F + +G E+ K
Sbjct: 379 CLVIDRETFNQTVGTFEELQK 399
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 130 bits (327), Expect = 2e-30
Identities = 84/277 (30%), Positives = 136/277 (49%), Gaps = 9/277 (3%)
Query: 110 TRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDA 169
T+R ++ AE D ++ + +PK+ ++ ++EA D KNL+ Q+ +++D
Sbjct: 74 TKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDC 133
Query: 170 MFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYN 229
M+ +I +GD G YV++ G + V +GV C FGELA++YN
Sbjct: 134 MYPVEYGKDSCIIKEGDVGSLVYVMEDGKVE--VTKEGVKLCTMGPGK--VFGELAILYN 189
Query: 230 TPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVV 289
R AT+ LW +DR F+ I+++ K Y F++S+P +SL K+
Sbjct: 190 CTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLA 249
Query: 290 DVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQY 349
DV+ Y +GE II QG D+FFI+ G V +T + + V + +G +
Sbjct: 250 DVLEETHYENGEYIIRQGARGDTFFIISKGTVNVT-----REDSPSEDPVFLRTLGKGDW 304
Query: 350 FGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLG 386
FGE AL R A+ A V CL +D +F+ L+G
Sbjct: 305 FGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIG 341
Score = 55.8 bits (133), Expect = 7e-08
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Query: 147 EACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
E K + F++L E +S++ D + E ++GE++I QG GD F++I +GT ++ + D
Sbjct: 229 EFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNV-TRED 287
Query: 207 GVG------RCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNN 260
R +G D FGE AL R A + A +DR +F+ +I +
Sbjct: 288 SPSEDPVFLRTLGKGD---WFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLD 344
Query: 261 AKKRKMYE------SFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSF 313
K YE + F +L+ S+ ++D +G + E + + + + +F
Sbjct: 345 DVSNKAYEDAEAKAKYEAEAAFFANLKLSD-FNIIDTLGVGGFGRVELVQLKSEESKTF 402
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 125 bits (315), Expect = 5e-29
Identities = 84/279 (30%), Positives = 133/279 (47%), Gaps = 9/279 (3%)
Query: 108 RFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVL 167
R TR + AE D ++ K++ ++ ++EA D KNL+ Q+ +++
Sbjct: 57 RTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIV 116
Query: 168 DAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALM 227
D M+ +I +GD G YV++ G + V +GV C FGELA++
Sbjct: 117 DCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVE--VTKEGVKLCTMGPGK--VFGELAIL 172
Query: 228 YNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLK 287
YN R AT+ LW +DR F+ I+++ K Y F++S+P +SL K
Sbjct: 173 YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSK 232
Query: 288 VVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRG 347
+ DV+ Y +GE II QG D+FFI+ G V +T + + V + +G
Sbjct: 233 LADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVT-----REDSPSEDPVFLRTLGKG 287
Query: 348 QYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLG 386
+FGE AL R A+ A V CL +D +F+ L+G
Sbjct: 288 DWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIG 326
Score = 55.8 bits (133), Expect = 7e-08
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Query: 147 EACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
E K + F++L E +S++ D + E ++GE++I QG GD F++I +GT ++ + D
Sbjct: 214 EFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNV-TRED 272
Query: 207 GVG------RCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNN 260
R +G D FGE AL R A + A +DR +F+ +I +
Sbjct: 273 SPSEDPVFLRTLGKGD---WFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLD 329
Query: 261 AKKRKMYE------SFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSF 313
K YE + F +L+ S+ ++D +G + E + + + + +F
Sbjct: 330 DVSNKAYEDAEAKAKYEAEAAFFANLKLSD-FNIIDTLGVGGFGRVELVQLKSEESKTF 387
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 48.5 bits (114), Expect = 1e-05
Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 9/136 (6%)
Query: 137 KTDDQRNRLQEAC---KDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYV 193
+TD++ + + E K + N +++ VL +FE K G + QGD G ++Y+
Sbjct: 186 RTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL--LFEPHSKAGTVLFSQGDKGTSWYI 243
Query: 194 IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGA-LWGLDRVTF 252
I +G+ ++ G+ + D+ FG+LAL+ + PRAATI +D+ F
Sbjct: 244 IWKGSVNVVTHGKGLVTTLHEGDD---FGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300
Query: 253 RRIIVKNNAKKRKMYE 268
RII AK ++ E
Sbjct: 301 NRIIKDVEAKTMRLEE 316
Score = 38.9 bits (89), Expect = 0.009
Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 13/88 (14%)
Query: 300 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNK 359
G + +QGD S++I+ G V + KG + G FG+LALV +
Sbjct: 228 GTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL----------VTTLHEGDDFGQLALVNDA 277
Query: 360 PRAASAHAIGTVKC--LAMDVQAFERLL 385
PRAA+ + C L +D Q F R++
Sbjct: 278 PRAATI-ILREDNCHFLRVDKQDFNRII 304
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 48.5 bits (114), Expect = 1e-05
Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 9/136 (6%)
Query: 137 KTDDQRNRLQEAC---KDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYV 193
+TD++ + + E K + N +++ VL +FE K G + QGD G ++Y+
Sbjct: 186 RTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL--LFEPHSKAGTVLFSQGDKGTSWYI 243
Query: 194 IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGA-LWGLDRVTF 252
I +G+ ++ G+ + D+ FG+LAL+ + PRAATI +D+ F
Sbjct: 244 IWKGSVNVVTHGKGLVTTLHEGDD---FGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300
Query: 253 RRIIVKNNAKKRKMYE 268
RII AK ++ E
Sbjct: 301 NRIIKDVEAKTMRLEE 316
Score = 38.9 bits (89), Expect = 0.009
Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 13/88 (14%)
Query: 300 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNK 359
G + +QGD S++I+ G V + KG + G FG+LALV +
Sbjct: 228 GTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL----------VTTLHEGDDFGQLALVNDA 277
Query: 360 PRAASAHAIGTVKC--LAMDVQAFERLL 385
PRAA+ + C L +D Q F R++
Sbjct: 278 PRAATI-ILREDNCHFLRVDKQDFNRII 304
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 48.5 bits (114), Expect = 1e-05
Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 9/136 (6%)
Query: 137 KTDDQRNRLQEAC---KDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYV 193
+TD++ + + E K + N +++ VL +FE K G + QGD G ++Y+
Sbjct: 228 RTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL--LFEPHSKAGTVLFSQGDKGTSWYI 285
Query: 194 IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGA-LWGLDRVTF 252
I +G+ ++ G+ + D+ FG+LAL+ + PRAATI +D+ F
Sbjct: 286 IWKGSVNVVTHGKGLVTTLHEGDD---FGQLALVNDAPRAATIILREDNCHFLRVDKQDF 342
Query: 253 RRIIVKNNAKKRKMYE 268
RII AK ++ E
Sbjct: 343 NRIIKDVEAKTMRLEE 358
Score = 38.9 bits (89), Expect = 0.009
Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 13/88 (14%)
Query: 300 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNK 359
G + +QGD S++I+ G V + KG + G FG+LALV +
Sbjct: 270 GTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL----------VTTLHEGDDFGQLALVNDA 319
Query: 360 PRAASAHAIGTVKC--LAMDVQAFERLL 385
PRAA+ + C L +D Q F R++
Sbjct: 320 PRAATI-ILREDNCHFLRVDKQDFNRII 346
>gi|116256487 patatin-like phospholipase domain containing 6 [Homo
sapiens]
Length = 1327
Score = 47.0 bits (110), Expect = 3e-05
Identities = 67/314 (21%), Positives = 118/314 (37%), Gaps = 25/314 (7%)
Query: 59 GDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAE 118
GD+ GG P + A E + S +EE + + A P + A C
Sbjct: 375 GDISGLQGG--PRSDFDMAYERGRI-SVSLQEEASGGSLAAPARTPTQEPREQPAGACEY 431
Query: 119 AYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDG 178
+Y DE P Q + + EA K L K + E S + + K G
Sbjct: 432 SYCEDESATGGCP--FGPYQGRQTSSIFEAAKQELA-KLMRIEDPSLLNSRVLLHHAKAG 488
Query: 179 EHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGR--CVGNYDNRGSFGELALMYNTPRAATI 236
+ QGD + + + G +Y + C+ G+LA++ P T+
Sbjct: 489 TIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTL 548
Query: 237 TATSPGALWGLDRVTFRRII-VKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTK 295
A + + F I+ + + + PF++ ++F+ V+
Sbjct: 549 RAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEA---- 604
Query: 296 VYNDGEQIIAQGDSADSFFIVESGEVKITMKR-KGKSEVEENGAVEIARCSRGQYFGELA 354
G + QGD +D +IV +G ++ ++R GK E+ + RG G +
Sbjct: 605 ----GRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL-------VGEYGRGDLIGVVE 653
Query: 355 LVTNKPRAASAHAI 368
+T +PRA + HA+
Sbjct: 654 ALTRQPRATTVHAV 667
Score = 28.9 bits (63), Expect = 9.1
Identities = 22/82 (26%), Positives = 31/82 (37%), Gaps = 1/82 (1%)
Query: 175 VKDGEHVIDQGDDGDNFYVIDRGTF-DIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRA 233
V+ G + QGD D Y++ G + + G VG Y G + + PRA
Sbjct: 602 VEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRA 661
Query: 234 ATITATSPGALWGLDRVTFRRI 255
T+ A L L T I
Sbjct: 662 TTVHAVRDTELAKLPEGTLGHI 683
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 46.6 bits (109), Expect = 4e-05
Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 16/152 (10%)
Query: 128 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKDGE 179
DA R+I K QR + L+ +++L K L +++ VL +FE K G
Sbjct: 181 DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 238
Query: 180 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 239
+ +QG++G ++Y+I +G+ ++ + GV V FG+LAL+ + PRAA+I
Sbjct: 239 VLFNQGEEGTSWYIILKGSVNVVIYGKGV---VCTLHEGDDFGKLALVNDAPRAASIVLR 295
Query: 240 SPGA-LWGLDRVTFRRII--VKNNAKKRKMYE 268
+D+ F RI+ V+ N + K ++
Sbjct: 296 EDNCHFLRVDKEDFNRILRDVEANTVRLKEHD 327
Score = 38.9 bits (89), Expect = 0.009
Identities = 33/124 (26%), Positives = 53/124 (42%), Gaps = 17/124 (13%)
Query: 268 ESFIESLPFLKSLEFSERLKVVDVIGTKVYND----GEQIIAQGDSADSFFIVESGEVKI 323
E E L +K+L ++ G ++ G + QG+ S++I+ G V +
Sbjct: 201 EIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNV 260
Query: 324 TMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKC--LAMDVQAF 381
+ KG + G FG+LALV + PRAAS + C L +D + F
Sbjct: 261 VIYGKGV----------VCTLHEGDDFGKLALVNDAPRAASI-VLREDNCHFLRVDKEDF 309
Query: 382 ERLL 385
R+L
Sbjct: 310 NRIL 313
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 46.6 bits (109), Expect = 4e-05
Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 16/152 (10%)
Query: 128 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKDGE 179
DA R+I K QR + L+ +++L K L +++ VL +FE K G
Sbjct: 325 DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 382
Query: 180 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 239
+ +QG++G ++Y+I +G+ ++ + GV V FG+LAL+ + PRAA+I
Sbjct: 383 VLFNQGEEGTSWYIILKGSVNVVIYGKGV---VCTLHEGDDFGKLALVNDAPRAASIVLR 439
Query: 240 SPGA-LWGLDRVTFRRII--VKNNAKKRKMYE 268
+D+ F RI+ V+ N + K ++
Sbjct: 440 EDNCHFLRVDKEDFNRILRDVEANTVRLKEHD 471
Score = 40.8 bits (94), Expect = 0.002
Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 8/111 (7%)
Query: 150 KDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVK----- 204
K++ F+ P + Q+ + + ++ G + QGD G N+Y + G+ D+ V
Sbjct: 39 KEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 98
Query: 205 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRI 255
D V C +FGE +++ NTPR ATI L +++ F+ +
Sbjct: 99 QDAVTICTLGIGT--AFGE-SILDNTPRHATIVTRESSELLRIEQKDFKAL 146
Score = 38.9 bits (89), Expect = 0.009
Identities = 33/124 (26%), Positives = 53/124 (42%), Gaps = 17/124 (13%)
Query: 268 ESFIESLPFLKSLEFSERLKVVDVIGTKVYND----GEQIIAQGDSADSFFIVESGEVKI 323
E E L +K+L ++ G ++ G + QG+ S++I+ G V +
Sbjct: 345 EIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNV 404
Query: 324 TMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKC--LAMDVQAF 381
+ KG + G FG+LALV + PRAAS + C L +D + F
Sbjct: 405 VIYGKGV----------VCTLHEGDDFGKLALVNDAPRAASI-VLREDNCHFLRVDKEDF 453
Query: 382 ERLL 385
R+L
Sbjct: 454 NRIL 457
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/153 (22%), Positives = 64/153 (41%), Gaps = 4/153 (2%)
Query: 154 LFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVG 213
LF N DP ++ +L + ++ + G+++I +G G Y I G + K G
Sbjct: 544 LFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK----GNKEM 599
Query: 214 NYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIES 273
+ FGE+ L+ R A++ A + L+ L F ++ + +R I+
Sbjct: 600 KLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDR 659
Query: 274 LPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQ 306
L + KV + + V+N+ E I Q
Sbjct: 660 LDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQ 692
Score = 41.6 bits (96), Expect = 0.001
Identities = 32/133 (24%), Positives = 57/133 (42%), Gaps = 17/133 (12%)
Query: 253 RRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADS 312
R IV N +K + S+P + + + ++ + +V+ G+ II +G
Sbjct: 527 REEIVNFNCRK------LVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKK 580
Query: 313 FFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVK 372
+ ++ G V + K G E+ + S G YFGE+ L+T R AS A +
Sbjct: 581 MYFIQHGVVSVLTK--GNKEM---------KLSDGSYFGEICLLTRGRRTASVRADTYCR 629
Query: 373 CLAMDVQAFERLL 385
++ V F +L
Sbjct: 630 LYSLSVDNFNEVL 642
>gi|148727335 patatin-like phospholipase domain containing 7 isoform
a [Homo sapiens]
Length = 1342
Score = 43.9 bits (102), Expect = 3e-04
Identities = 53/232 (22%), Positives = 99/232 (42%), Gaps = 35/232 (15%)
Query: 148 ACKDILLFKNLDPEQMSQVLDAMFEKL-VKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
A KD+L L+ S +LD L V G V QGD + + G +Y
Sbjct: 480 AKKDLLTLMKLED---SSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQ--- 533
Query: 207 GVGRCVGNYDNRGSF--------GELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 258
R +G+ ++ F G+LA++ P T+ A + + + F I+ K
Sbjct: 534 ---RKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRK 590
Query: 259 NNAKKRKMYESFIESLP-FLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE 317
+ + ++ + F++ ++F+ L V+V G I QGD +D +I+
Sbjct: 591 QPTVVLGVAHTVVKRMSSFVRQIDFA--LDWVEV------EAGRAIYRQGDKSDCTYIML 642
Query: 318 SGEVKITMKRKGKSEVEENGAVEIA-RCSRGQYFGELALVTNKPRAASAHAI 368
SG ++ +++ ++G +A RG G + +T++ RA + HA+
Sbjct: 643 SGRLRSVIRK-------DDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAV 687
>gi|148727290 patatin-like phospholipase domain containing 7 isoform
b [Homo sapiens]
Length = 1317
Score = 43.9 bits (102), Expect = 3e-04
Identities = 53/232 (22%), Positives = 99/232 (42%), Gaps = 35/232 (15%)
Query: 148 ACKDILLFKNLDPEQMSQVLDAMFEKL-VKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
A KD+L L+ S +LD L V G V QGD + + G +Y
Sbjct: 455 AKKDLLTLMKLED---SSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQ--- 508
Query: 207 GVGRCVGNYDNRGSF--------GELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 258
R +G+ ++ F G+LA++ P T+ A + + + F I+ K
Sbjct: 509 ---RKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRK 565
Query: 259 NNAKKRKMYESFIESLP-FLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVE 317
+ + ++ + F++ ++F+ L V+V G I QGD +D +I+
Sbjct: 566 QPTVVLGVAHTVVKRMSSFVRQIDFA--LDWVEV------EAGRAIYRQGDKSDCTYIML 617
Query: 318 SGEVKITMKRKGKSEVEENGAVEIA-RCSRGQYFGELALVTNKPRAASAHAI 368
SG ++ +++ ++G +A RG G + +T++ RA + HA+
Sbjct: 618 SGRLRSVIRK-------DDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAV 662
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 42.0 bits (97), Expect = 0.001
Identities = 35/154 (22%), Positives = 66/154 (42%), Gaps = 6/154 (3%)
Query: 154 LFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCV- 212
LF N DP ++ +L + ++ + G+++I +G G Y I G + K + +
Sbjct: 595 LFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLAD 654
Query: 213 GNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIE 272
G+Y FGE+ L+ R A++ A + L+ L F ++ + +R ++
Sbjct: 655 GSY-----FGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALD 709
Query: 273 SLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQ 306
L + KV + + V+N E I Q
Sbjct: 710 RLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQ 743
Score = 40.4 bits (93), Expect = 0.003
Identities = 28/133 (21%), Positives = 57/133 (42%), Gaps = 17/133 (12%)
Query: 253 RRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADS 312
R I+ N +K + S+P + + + ++ + +V+ G+ II +G
Sbjct: 578 REEIINFNCRK------LVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKK 631
Query: 313 FFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVK 372
+ ++ G V + K ++++ + G YFGE+ L+T R AS A +
Sbjct: 632 MYFIQHGVVSVLTKGNKETKLAD-----------GSYFGEICLLTRGRRTASVRADTYCR 680
Query: 373 CLAMDVQAFERLL 385
++ V F +L
Sbjct: 681 LYSLSVDNFNEVL 693
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/181 (22%), Positives = 75/181 (41%), Gaps = 11/181 (6%)
Query: 130 ESRIIHPKTDDQRNRLQEA-CKDIL----LFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQ 184
E I++ D R + C+ ++ LF N DP ++ +L + ++ + G+++I +
Sbjct: 446 EENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIRE 505
Query: 185 GDDGDNFYVIDRGTFDIYVKCDGVGRCV-GNYDNRGSFGELALMYNTPRAATITATSPGA 243
G G Y I G + K + G+Y FGE+ L+ R A++ A +
Sbjct: 506 GAVGKKMYFIQHGVAGVITKSSKEMKLTDGSY-----FGEICLLTKGRRTASVRADTYCR 560
Query: 244 LWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQI 303
L+ L F ++ + +R I+ L + K + T V+N+ E
Sbjct: 561 LYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENE 620
Query: 304 I 304
I
Sbjct: 621 I 621
Score = 36.6 bits (83), Expect = 0.043
Identities = 27/133 (20%), Positives = 55/133 (41%), Gaps = 17/133 (12%)
Query: 253 RRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADS 312
R IV N +K + ++P + + + ++ + +V+ G+ II +G
Sbjct: 458 REEIVNFNCRK------LVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKK 511
Query: 313 FFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVK 372
+ ++ G + K + ++ + G YFGE+ L+T R AS A +
Sbjct: 512 MYFIQHGVAGVITKSSKEMKLTD-----------GSYFGEICLLTKGRRTASVRADTYCR 560
Query: 373 CLAMDVQAFERLL 385
++ V F +L
Sbjct: 561 LYSLSVDNFNEVL 573
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 38.1 bits (87), Expect = 0.015
Identities = 22/106 (20%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 269 SFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRK 328
S + + ++ E S ++V + + Y+ GE + +GD +I+ G++ +
Sbjct: 341 STLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAV----- 395
Query: 329 GKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCL 374
V ++G + A G YFGE++++ K + +K L
Sbjct: 396 ----VADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSL 437
Score = 30.8 bits (68), Expect = 2.4
Identities = 31/139 (22%), Positives = 60/139 (43%), Gaps = 14/139 (10%)
Query: 152 ILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRC 211
+ +F+N + + +++ + + GE+V +GD G Y+I G + V DG+ +
Sbjct: 346 VQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAV-VADDGITQ- 403
Query: 212 VGNYDNRGS---FGELAL------MYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAK 262
Y G+ FGE+++ M R A I + L+ L + R ++ +
Sbjct: 404 ---YAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQA 460
Query: 263 KRKMYESFIESLPFLKSLE 281
+ M E E L + L+
Sbjct: 461 QTIMEEKGREILLKMNKLD 479
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 37.7 bits (86), Expect = 0.020
Identities = 19/80 (23%), Positives = 38/80 (47%), Gaps = 9/80 (11%)
Query: 295 KVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELA 354
+VY+ G+ I +GD +I++ G++ + V ++G + S G YFGE++
Sbjct: 567 QVYSPGDYICKKGDIGREMYIIKEGKLAV---------VADDGVTQFVVLSDGSYFGEIS 617
Query: 355 LVTNKPRAASAHAIGTVKCL 374
++ K A +K +
Sbjct: 618 ILNIKGSKAGNRRTANIKSI 637
Score = 29.3 bits (64), Expect = 6.9
Identities = 18/81 (22%), Positives = 41/81 (50%), Gaps = 2/81 (2%)
Query: 147 EACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
+ K + +F + + + +++ + ++ G+++ +GD G Y+I G + V D
Sbjct: 541 DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAV-VADD 599
Query: 207 GVGRCVGNYDNRGSFGELALM 227
GV + V D FGE++++
Sbjct: 600 GVTQFVVLSDG-SYFGEISIL 619
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 37.7 bits (86), Expect = 0.020
Identities = 19/80 (23%), Positives = 38/80 (47%), Gaps = 9/80 (11%)
Query: 295 KVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELA 354
+VY+ G+ I +GD +I++ G++ + V ++G + S G YFGE++
Sbjct: 498 QVYSPGDYICKKGDIGREMYIIKEGKLAV---------VADDGVTQFVVLSDGSYFGEIS 548
Query: 355 LVTNKPRAASAHAIGTVKCL 374
++ K A +K +
Sbjct: 549 ILNIKGSKAGNRRTANIKSI 568
Score = 29.3 bits (64), Expect = 6.9
Identities = 18/81 (22%), Positives = 41/81 (50%), Gaps = 2/81 (2%)
Query: 147 EACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
+ K + +F + + + +++ + ++ G+++ +GD G Y+I G + V D
Sbjct: 472 DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAV-VADD 530
Query: 207 GVGRCVGNYDNRGSFGELALM 227
GV + V D FGE++++
Sbjct: 531 GVTQFVVLSDG-SYFGEISIL 550
>gi|8394343 sperm autoantigenic protein 17 [Homo sapiens]
Length = 151
Score = 37.0 bits (84), Expect = 0.033
Identities = 17/41 (41%), Positives = 25/41 (60%)
Query: 5 IPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENER 45
IP G LL+G T E+LR QP ++ FA +F L ++ E+
Sbjct: 12 IPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREK 52
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 36.2 bits (82), Expect = 0.057
Identities = 32/148 (21%), Positives = 64/148 (43%), Gaps = 23/148 (15%)
Query: 244 LWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSER------LKVVDVIGTKVY 297
LW + + ++K+ K K + L LK + + +++V + V+
Sbjct: 426 LWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVF 485
Query: 298 NDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVT 357
+ G+ I +GD +I+ G++ + V ++G + S G YFGE++++
Sbjct: 486 SPGDYICKKGDIGKEMYIINEGKLAV---------VADDGVTQFVVLSDGSYFGEISILN 536
Query: 358 NK------PRAASAHAIG--TVKCLAMD 377
K R A+ +IG + CL+ D
Sbjct: 537 IKGSKSGNRRTANIRSIGYSDLFCLSKD 564
Score = 30.4 bits (67), Expect = 3.1
Identities = 18/81 (22%), Positives = 42/81 (51%), Gaps = 2/81 (2%)
Query: 147 EACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
+ K + +F++ + + +++ + + G+++ +GD G Y+I+ G + V D
Sbjct: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAV-VADD 515
Query: 207 GVGRCVGNYDNRGSFGELALM 227
GV + V D FGE++++
Sbjct: 516 GVTQFVVLSDG-SYFGEISIL 535
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 36.2 bits (82), Expect = 0.057
Identities = 32/148 (21%), Positives = 64/148 (43%), Gaps = 23/148 (15%)
Query: 244 LWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSER------LKVVDVIGTKVY 297
LW + + ++K+ K K + L LK + + +++V + V+
Sbjct: 444 LWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVF 503
Query: 298 NDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVT 357
+ G+ I +GD +I+ G++ + V ++G + S G YFGE++++
Sbjct: 504 SPGDYICKKGDIGKEMYIINEGKLAV---------VADDGVTQFVVLSDGSYFGEISILN 554
Query: 358 NK------PRAASAHAIG--TVKCLAMD 377
K R A+ +IG + CL+ D
Sbjct: 555 IKGSKSGNRRTANIRSIGYSDLFCLSKD 582
Score = 30.4 bits (67), Expect = 3.1
Identities = 18/81 (22%), Positives = 42/81 (51%), Gaps = 2/81 (2%)
Query: 147 EACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 206
+ K + +F++ + + +++ + + G+++ +GD G Y+I+ G + V D
Sbjct: 475 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAV-VADD 533
Query: 207 GVGRCVGNYDNRGSFGELALM 227
GV + V D FGE++++
Sbjct: 534 GVTQFVVLSDG-SYFGEISIL 553
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 35.8 bits (81), Expect = 0.074
Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 4/107 (3%)
Query: 154 LFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVG 213
LFK D + + +L + L G+ V +G+ G Y+I G + DG + +
Sbjct: 524 LFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT-KVLV 582
Query: 214 NYDNRGSFGELALMY---NTPRAATITATSPGALWGLDRVTFRRIIV 257
FGE++L+ R A + A L LD+ T + I+V
Sbjct: 583 TLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILV 629
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 35.4 bits (80), Expect = 0.097
Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 22/125 (17%)
Query: 78 EEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPK 137
E P+ S+ ++ E+EE D P+ R R + E++ A+ K
Sbjct: 225 EGPVDSEDDEEEDEEIDRTD------PLQGRDLVRECL---------EKEPAD------K 263
Query: 138 TDDQRNRLQEACKDILLFKNLDPEQMSQVLDAM-FEKLVKDGEHVIDQGDDGDNFYVIDR 196
TDD +L E + F N+ ++ M FE + + G +++ G + D++YVI
Sbjct: 264 TDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILN 323
Query: 197 GTFDI 201
GT +I
Sbjct: 324 GTVEI 328
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 35.0 bits (79), Expect = 0.13
Identities = 29/145 (20%), Positives = 59/145 (40%), Gaps = 12/145 (8%)
Query: 271 IESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGK 330
+ +P + S V+ + +V+ G+ ++ +G + ++ G + + +
Sbjct: 423 VAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLAR---- 478
Query: 331 SEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCME 390
GA + R + G YFGE+ L+T R AS A + ++ V F +L
Sbjct: 479 ------GARD-TRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEE-FP 530
Query: 391 IMKRNIATYEEQLVALFGTNMDIVE 415
+M+R T + G I++
Sbjct: 531 MMRRAFETVAMDRLLRIGKKNSILQ 555
>gi|156938257 leucine rich repeat containing 16B [Homo sapiens]
Length = 1372
Score = 34.7 bits (78), Expect = 0.17
Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 1/75 (1%)
Query: 65 AGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDE 124
A G + GVN + S + E E P D G AP+ + TRRA C + PD
Sbjct: 1299 AEAGDAAPGVNKPRLRLSSQQDQEEPEVQGPPDPGRRTAPLKPKRTRRAQSC-DKLEPDR 1357
Query: 125 EEDDAESRIIHPKTD 139
+ P TD
Sbjct: 1358 RRPPDPTGTSEPGTD 1372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,716,382
Number of Sequences: 37866
Number of extensions: 719179
Number of successful extensions: 2742
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 2604
Number of HSP's gapped (non-prelim): 112
length of query: 418
length of database: 18,247,518
effective HSP length: 105
effective length of query: 313
effective length of database: 14,271,588
effective search space: 4467007044
effective search space used: 4467007044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.