Guide to the Human Genome
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Search of human proteins with 47132519

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
         (1250 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47132519 Ras association and pleckstrin homology domains 1 is...  2551   0.0  
gi|42740893 Ras association and pleckstrin homology domains 1 is...  1148   0.0  
gi|56118221 amyloid beta (A4) precursor protein-binding, family ...   477   e-134
gi|160707881 formin 2 [Homo sapiens]                                  194   6e-49
gi|163965366 nascent polypeptide-associated complex alpha subuni...   174   5e-43
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   169   2e-41
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  168   3e-41
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  168   3e-41
gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]    159   2e-38
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  159   2e-38
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   159   2e-38
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...   158   3e-38
gi|116284392 mucin 2 precursor [Homo sapiens]                         155   2e-37
gi|48762697 growth factor receptor-bound protein 10 isoform c [H...   152   2e-36
gi|48762695 growth factor receptor-bound protein 10 isoform c [H...   152   2e-36
gi|48762679 growth factor receptor-bound protein 10 isoform a [H...   152   2e-36
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   150   6e-36
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...   144   5e-34
gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]     143   1e-33
gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]     143   1e-33
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   142   2e-33
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   141   4e-33
gi|110349719 titin isoform N2-A [Homo sapiens]                        137   5e-32
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    137   6e-32
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]         136   1e-31
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]         136   1e-31
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]         136   1e-31
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]             129   1e-29
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]      127   7e-29
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]        126   1e-28

>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 2551 bits (6613), Expect = 0.0
 Identities = 1250/1250 (100%), Positives = 1250/1250 (100%)

Query: 1    MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60
            MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET
Sbjct: 1    MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60

Query: 61   NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120
            NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK
Sbjct: 61   NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120

Query: 121  LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180
            LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK
Sbjct: 121  LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180

Query: 181  PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240
            PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ
Sbjct: 181  PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240

Query: 241  PITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNL 300
            PITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNL
Sbjct: 241  PITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNL 300

Query: 301  MDKSHCGYSLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALF 360
            MDKSHCGYSLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALF
Sbjct: 301  MDKSHCGYSLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALF 360

Query: 361  KNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLL 420
            KNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLL
Sbjct: 361  KNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLL 420

Query: 421  RASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQ 480
            RASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQ
Sbjct: 421  RASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQ 480

Query: 481  YIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSS 540
            YIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSS
Sbjct: 481  YIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSS 540

Query: 541  SSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNR 600
            SSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNR
Sbjct: 541  SSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNR 600

Query: 601  PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSA 660
            PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSA
Sbjct: 601  PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSA 660

Query: 661  APMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720
            APMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT
Sbjct: 661  APMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK 780
            PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK
Sbjct: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK 780

Query: 781  PLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL 840
            PLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL
Sbjct: 781  PLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL 840

Query: 841  PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKA 900
            PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKA
Sbjct: 841  PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKA 900

Query: 901  KPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKT 960
            KPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKT
Sbjct: 901  KPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKT 960

Query: 961  SKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPP 1020
            SKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPP
Sbjct: 961  SKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPP 1020

Query: 1021 PAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPET 1080
            PAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPET
Sbjct: 1021 PAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPET 1080

Query: 1081 ELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISE 1140
            ELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISE
Sbjct: 1081 ELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISE 1140

Query: 1141 QPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDM 1200
            QPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDM
Sbjct: 1141 QPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDM 1200

Query: 1201 ALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW 1250
            ALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW
Sbjct: 1201 ALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW 1250


>gi|42740893 Ras association and pleckstrin homology domains 1
           isoform 3 [Homo sapiens]
          Length = 644

 Score = 1148 bits (2969), Expect = 0.0
 Identities = 592/644 (91%), Positives = 592/644 (91%), Gaps = 52/644 (8%)

Query: 1   MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60
           MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET
Sbjct: 1   MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60

Query: 61  NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120
           NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK
Sbjct: 61  NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120

Query: 121 LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180
           LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK
Sbjct: 121 LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180

Query: 181 PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240
           PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ
Sbjct: 181 PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240

Query: 241 PITE----------------------------------------------------EEQA 248
           PITE                                                    EEQA
Sbjct: 241 PITEHAISLRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQA 300

Query: 249 AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY 308
           AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY
Sbjct: 301 AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY 360

Query: 309 SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL 368
           SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL
Sbjct: 361 SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL 420

Query: 369 GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV 428
           GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV
Sbjct: 421 GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV 480

Query: 429 PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD 488
           PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD
Sbjct: 481 PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD 540

Query: 489 DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS 548
           DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS
Sbjct: 541 DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS 600

Query: 549 NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK 592
           NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK
Sbjct: 601 NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK 644


>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
           member 1 interacting protein [Homo sapiens]
          Length = 666

 Score =  477 bits (1227), Expect = e-134
 Identities = 273/635 (42%), Positives = 363/635 (57%), Gaps = 93/635 (14%)

Query: 155 DVTAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVHSISNSSHSSITS 214
           D+ A +      + EA Q+++    + L    H  +  A   S A   S+   ++ + T 
Sbjct: 63  DLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAA--SLGYGTNVAATG 120

Query: 215 AASSMDSLDIDKVTRPQELDLTHQG-QPITEEEQAAKLKAEKIRVALEKIKEAQVKKLVI 273
            +   D L         +L L     +P+++EE+ A+ KA+KI++ALEK+KEA+VKKLV+
Sbjct: 121 ISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVV 180

Query: 274 RVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHENL 333
           +VHM+D+S+K++MVDERQ  R VLDNL +K+HC  ++DW L E   ELQ+ER FEDHEN+
Sbjct: 181 KVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENV 240

Query: 334 VENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL---GKKETAE----MADRNKEVLLE 386
           VE L +WTRD++NK++F+E+ EKYA+FKNPQN+ L   GKKE+ E    M  +NKE LLE
Sbjct: 241 VEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLE 300

Query: 387 ECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLD 446
           E FCG+S+ VPE+EG L+LK+DGKKSWK+RYFLLRASGIYYVPKGK K SRDL CF+Q +
Sbjct: 301 ESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFE 360

Query: 447 HVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYG 506
           +VN+YYG  ++ KYKAPTDYC VLKHPQIQK+SQYIKYLCCDD RTL+QWV GIRIAKYG
Sbjct: 361 NVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYG 420

Query: 507 KQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGH 566
           K LY NYQ A+ +   A  WT+L + +  + +  S+ P++              TQP G 
Sbjct: 421 KTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKT------------GTTQPNGQ 468

Query: 567 V-RSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTP------- 618
           + ++   VS+V  EA +      E+SK +  ++   +   VP     PK   P       
Sbjct: 469 IPQATHSVSAVLQEAQRHA----ETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRR 524

Query: 619 --YTASQPSPP----------LPPPP----PPPPPPPP---PPPPPPPPLPSQSAPSAGS 659
              T+  P+ P          LP PP    PPPPPPPP   P  PPPPP   +  P    
Sbjct: 525 SSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPD--- 581

Query: 660 AAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPP 719
                                   F PP PP     +            +PPPPPPPP P
Sbjct: 582 ------------------------FVPPPPPSYAGIA---------GSELPPPPPPPPAP 608

Query: 720 TPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQH 754
            P       +P P     P    P PP +     H
Sbjct: 609 APAPVPDSARPPPAVAKRP----PVPPKRQENPGH 639



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 67/235 (28%), Positives = 91/235 (38%), Gaps = 59/235 (25%)

Query: 771 APLPPQAPPKPLVTIP---APTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPS 827
           AP  P   PK   T P    P +T +V+ V+ +A     T       K+PA    + P  
Sbjct: 450 APAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSK----DKKPALGNHHDPAV 505

Query: 828 PPTPPVP---VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ----FPPPPTPPAMES 880
           P  P  P   +PPP   ++ S  +  P +PL    +    + +      PPPP PP ++ 
Sbjct: 506 PRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDD 565

Query: 881 QPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPV----- 935
                      P+ PP               P PDF  PPP+     PPPPPS       
Sbjct: 566 -----------PELPP---------------PPPDFMEPPPD---FVPPPPPSYAGIAGS 596

Query: 936 ---PAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGA 987
              P PPPPP P  +P PD +  P            K+PP  P+R  +     GA
Sbjct: 597 ELPPPPPPPPAPAPAPVPDSARPP--------PAVAKRPPVPPKRQENPGHPGGA 643



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 63/247 (25%), Positives = 79/247 (31%), Gaps = 66/247 (26%)

Query: 648 PLPSQSAPSAGSAAPMF----VKYSTITRLQNASQHSG-ALFKPPTPPVMQSQSVKPQIL 702
           P    + P  G+  P        +S    LQ A +H+  +  K P        +V     
Sbjct: 451 PAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPH 510

Query: 703 VPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCA----PSLPQFSAPPPPLKIHQVQHITQV 758
            P + + PPPP      T GS    LK         P+ P    PPPP            
Sbjct: 511 APKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPP------------ 558

Query: 759 APPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPA 818
            PP P   P +P P P    P                       PP   PP PP+     
Sbjct: 559 -PPPPLDDPELPPPPPDFMEP-----------------------PPDFVPPPPPS--YAG 592

Query: 819 FPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM 878
              S +PP PP PP P P P             P    P P+V K+       PP PP  
Sbjct: 593 IAGSELPPPPPPPPAPAPAPV------------PDSARPPPAVAKR-------PPVPPKR 633

Query: 879 ESQPLKP 885
           +  P  P
Sbjct: 634 QENPGHP 640



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 34/75 (45%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 19 KEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANFSYRFSIYNLNEAL 78
          +  +D+D+MF   LGE+D LTQSL  D    P    P       A F+Y     +LNE+L
Sbjct: 3  ESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPP------RAEFNYSVGFKDLNESL 56

Query: 79 NQGETVDLDALMADL 93
          N  E  DLDALMADL
Sbjct: 57 NALEDQDLDALMADL 71



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 62/230 (26%), Positives = 95/230 (41%), Gaps = 31/230 (13%)

Query: 955  SPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSG-AEHPEPKRPSVDSLVSKFTPPAESGSP 1013
            S G KT  T+ P G+ P  T   ++ ++ +   AE  + K+P++ +      P A     
Sbjct: 455  STGPKTG-TTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAP- 512

Query: 1014 SKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDF 1073
             K +LPPP  PP     + SG              KA    G G       P+PP D   
Sbjct: 513  -KSSLPPP--PPVRRSSDTSG--------SPATPLKAKGTGGGG------LPAPPDDFLP 555

Query: 1074 PPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKR------ 1127
            PPPPP    PL   E+P        P    V P P  ++ ++  + PPP  P        
Sbjct: 556  PPPPP---PPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAP 612

Query: 1128 -NDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRK 1176
              DS R   A ++++P +     + P  P  +   +  F++DL + LQ+K
Sbjct: 613  VPDSARPPPA-VAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKK 661



 Score = 37.4 bits (85), Expect = 0.090
 Identities = 40/166 (24%), Positives = 60/166 (36%), Gaps = 39/166 (23%)

Query: 1096 NTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMAT----VVPQV 1151
            +T PK     P  Q      + +A         ++ R  +    ++P +       VP+ 
Sbjct: 455  STGPKTGTTQPNGQ------IPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRA 508

Query: 1152 PTSPKSSLSVQPGFLADLNRT------LQRKSITRHGSLSSR----MSRAEPTATMDDMA 1201
            P +PKSSL   P      + +      L+ K  T  G L +     +    P   +DD  
Sbjct: 509  PHAPKSSLPPPPPVRRSSDTSGSPATPLKAKG-TGGGGLPAPPDDFLPPPPPPPPLDDPE 567

Query: 1202 LPPPPPELLS---------DQQKAGYGGSHISGYATLRRGPPPAPP 1238
            LPPPPP+ +              AG  GS +         PPP PP
Sbjct: 568  LPPPPPDFMEPPPDFVPPPPPSYAGIAGSEL---------PPPPPP 604



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 14/34 (41%), Positives = 16/34 (47%), Gaps = 3/34 (8%)

Query: 928 PPPPPSPV---PAPPPPPPPTASPTPDKSGSPGK 958
           PPPP  PV   P PPPPP P +    +      K
Sbjct: 129 PPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADK 162



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 13/23 (56%), Positives = 14/23 (60%), Gaps = 2/23 (8%)

Query: 915 DFPPPP--PESSLVFPPPPPSPV 935
           D PPPP  P   L  PPPPP P+
Sbjct: 127 DLPPPPADPVLDLPLPPPPPEPL 149


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  194 bits (492), Expect = 6e-49
 Identities = 148/433 (34%), Positives = 172/433 (39%), Gaps = 85/433 (19%)

Query: 597  SMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPP------PPPPPPPPP---PPPP 647
            S + P   +VPP  P P +      + PS  +P PPP       PPPPPP P    PPPP
Sbjct: 867  SSSMPGLGMVPP--PPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPP 924

Query: 648  PLPSQS------APSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQI 701
            PLP          P AG   P  +  + I               PP PP+  +    P  
Sbjct: 925  PLPGAGILPLPPLPGAGIPPPPPLPGAAI---------------PPPPPLPGAGIPLPPP 969

Query: 702  LVPPNGVVPPPPP------PPPPPTPGSAMAQLKPAPCA-----PSLPQFSAPPPPLKIH 750
            L  P   +PPPPP      PPPPP PG+ +    P P A     P LP    PPPP    
Sbjct: 970  L--PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP---- 1023

Query: 751  QVQHITQVAPPTP------PPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPP 804
                   + PP P      PPPPP+P    P  PP P   IP P       P+     PP
Sbjct: 1024 -PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP------PPLPGAGIPP 1076

Query: 805  TPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQ 864
             P  P       P  P + IPP PP P V +PPP  P   +    PPP P + +P     
Sbjct: 1077 PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPP-PLPGAGIPPPPPLPGAGIPPPPPL 1135

Query: 865  IASQFPPPPTPPAMESQPLKPVPANVAPQSPP----AVKAKPKWQPSSIPVPSP----DF 916
              +  PPPP  P +   P  P+P    P  PP     +   P      IP P P      
Sbjct: 1136 PGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGI 1195

Query: 917  PPPPPESSLVFPPPPP------SPVPAPPPPPPPTASPTP---DKSGSP-----GKKTSK 962
            PPPPP      PPPPP       P PAPP PPP T  P P     SG P     G  T  
Sbjct: 1196 PPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLP 1255

Query: 963  TSSPGGKKPPPTP 975
            T    G  PPP P
Sbjct: 1256 TPQVCGFLPPPLP 1268



 Score =  188 bits (478), Expect = 2e-47
 Identities = 179/626 (28%), Positives = 216/626 (34%), Gaps = 188/626 (30%)

Query: 609  LSPQPKIVTPYTASQPSPPLPPPPPPP--------------------------------- 635
            +SP+ +I     + QP+  +  PPPPP                                 
Sbjct: 789  VSPR-RISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSS 847

Query: 636  --------PPPPPPP--------------PPPPPPLPSQSAPSAGSAAPMFVKYSTITRL 673
                    P PPP P              PPPPPPLP  + P+  S           T +
Sbjct: 848  AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-----------TAI 896

Query: 674  QNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPP-----PPPPPPTPGSAMAQL 728
                   G    PP PP +    + P   +P  G++P PP      PPPPP PG+A+   
Sbjct: 897  PQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956

Query: 729  KPAPCA-----PSLPQFSAPPPPLKIHQVQHITQVAPPTP----PPPPPIPAPLPPQAPP 779
             P P A     P LP    PPP              PP P    PPPPP+P    P  PP
Sbjct: 957  PPLPGAGIPLPPPLPGAGIPPP--------------PPLPGAGIPPPPPLPGAGIPPPPP 1002

Query: 780  KPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPT 839
             P   IP P       P+     PP P  P       P  P + IPP PP P   +PPP 
Sbjct: 1003 LPGAGIPPP------PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1056

Query: 840  LPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVK 899
             P   +    PPP P + +P       +  PPPP  P     P  P+P    P  PP   
Sbjct: 1057 -PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG 1115

Query: 900  AKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKK 959
            A     P   P+P    PPPPP      PPPPP P    PPPPP                
Sbjct: 1116 A---GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPP---------------- 1156

Query: 960  TSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLP 1019
                  PG   PPP P   + I        P P  P V             G P    LP
Sbjct: 1157 -----LPGAGIPPPPPLPGAGIP-------PPPPLPGV-------------GIPPPPPLP 1191

Query: 1020 PPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPE 1079
                PP P    L G  +P            P L G G       P PP  +  PPPP  
Sbjct: 1192 GVGIPPPP---PLPGAGIP----------PPPPLPGMGIPPAPAPPLPPPGTGIPPPP-- 1236

Query: 1080 TELPL--PPIEIPAVFSGN-TSPKVAVVNPQP---------QQWSKMSVKKAPPPTRP-- 1125
              LP+  PP+ +P V S    +P+V    P P             K S K+   P RP  
Sbjct: 1237 -LLPVSGPPL-LPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMK 1294

Query: 1126 -----------KRNDSTRLTQAEISE 1140
                       KR+ ST L   +I E
Sbjct: 1295 PLYWTRIQLHSKRDSSTSLIWEKIEE 1320



 Score =  126 bits (317), Expect = 1e-28
 Identities = 145/578 (25%), Positives = 184/578 (31%), Gaps = 150/578 (25%)

Query: 634  PPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQ 693
            PP    P  PP PP   S       S   + V    I+   ++ Q + ++ +PP PP + 
Sbjct: 758  PPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLL 817

Query: 694  SQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSA---PPPPLKIH 750
              + + Q             P   PP   S   Q        S  + S     PPPL   
Sbjct: 818  WSAGQGQ-------------PGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCT 864

Query: 751  QVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPV 810
            +           PPPPPP+P    P  P   +   P    T+ + P      PP P   +
Sbjct: 865  ESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPP----PPPPLPGAGI 920

Query: 811  PPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFP 870
            PP    P  P + I P PP P   +PP            PPP P + +P          P
Sbjct: 921  PPP---PPLPGAGILPLPPLPGAGIPP------------PPPLPGAAIP----------P 955

Query: 871  PPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPP 930
            PPP P A    P  P+P    P  PP   A     P   P+P    PPPPP      PPP
Sbjct: 956  PPPLPGAGIPLP-PPLPGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPPPLPGAGIPPP 1011

Query: 931  PPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSS-PGGKKPPPTPQRNSSIKSSSGAEH 989
            PP P    PPPPP   +  P     PG         PG   PPP P   + I        
Sbjct: 1012 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------- 1064

Query: 990  PEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAK 1049
            P P  P     +    P   +G P    LP    PP P    L GV +P           
Sbjct: 1065 PPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPPP---LPGVGIP----------P 1109

Query: 1050 APVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQ 1109
             P L G G    +  P P   +  PPPPP     LP   IP                   
Sbjct: 1110 PPPLPGAG----IPPPPPLPGAGIPPPPP-----LPGAGIP------------------- 1141

Query: 1110 QWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADL 1169
                      PPP  P+                     +P  P  P + +   P      
Sbjct: 1142 ----------PPPPLPRVG-------------------IPPPPPLPGAGIPPPPPLPG-- 1170

Query: 1170 NRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207
                               +   P   +  + +PPPPP
Sbjct: 1171 -------------------AGIPPPPPLPGVGIPPPPP 1189



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 75/320 (23%), Positives = 106/320 (33%), Gaps = 64/320 (20%)

Query: 920  PPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGS-----------PGKKTSKTSSPGG 968
            P E   V   PP   +P  PP PP   S    K  S             +  S   +   
Sbjct: 748  PTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSI 807

Query: 969  KKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPG 1028
             +PPP P    S+  S+G   P  + P   S   + +      S  K +   P+ PP P 
Sbjct: 808  SQPPPPP----SLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP- 862

Query: 1029 KLNLSGVNLPGVLQQGCVSAKAPVLSG-----------------RGKDSVVEFPSPPSDS 1071
                S  ++PG+   G V    P L G                 +G + +   P P   +
Sbjct: 863  -CTESSSSMPGL---GMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGA 918

Query: 1072 DFPPPPP---ETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRN 1128
              PPPPP      LPLPP+    +      P  A+  P P   + + +   PPP      
Sbjct: 919  GIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPL---PPP------ 969

Query: 1129 DSTRLTQAEISEQPTM-ATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSR 1187
                L  A I   P +    +P  P  P + +   P         L    I     L   
Sbjct: 970  ----LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP--------PLPGAGIPPPPPLPG- 1016

Query: 1188 MSRAEPTATMDDMALPPPPP 1207
             +   P   +    +PPPPP
Sbjct: 1017 -AGIPPPPPLPGAGIPPPPP 1035



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 68/270 (25%), Positives = 91/270 (33%), Gaps = 77/270 (28%)

Query: 959  KTSKTSSPGGKKPPPTPQRNSSIKSSSGAEH-PEPKRPSVDSLV---SKFTPPAESGSPS 1014
            +TS T   G    PP            GAE  P+ K  S  SL+    + +   +S  P+
Sbjct: 745  QTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804

Query: 1015 KETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVE----FPSPP-- 1068
            +    PP   P P  L  +G   PG      +S +          S  +     PSPP  
Sbjct: 805  QSISQPP---PPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL 861

Query: 1069 ----SDSDFP-----PPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKA 1119
                S S  P     PPPP    PLP + +P      T P  A+  P P Q ++M     
Sbjct: 862  PCTESSSSMPGLGMVPPPPP---PLPGMTVP------TLPSTAIPQPPPLQGTEM----L 908

Query: 1120 PPPTRPKRNDSTRLTQAEISEQPTM--ATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKS 1177
            PPP  P       L  A I   P +  A ++P  P          PG             
Sbjct: 909  PPPPPP-------LPGAGIPPPPPLPGAGILPLPPL---------PG------------- 939

Query: 1178 ITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207
                       +   P   +   A+PPPPP
Sbjct: 940  -----------AGIPPPPPLPGAAIPPPPP 958



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 47/190 (24%), Positives = 69/190 (36%), Gaps = 34/190 (17%)

Query: 851  PPSPLSPVPSVVKQI----------ASQFP-PPPTPPAMESQPLKPVPANVA-----PQS 894
            PP+ +SP P     +          A + P  P T  A+ +  L  +P ++A     PQ 
Sbjct: 235  PPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSA--LSDLPESLAAEPREPQQ 292

Query: 895  PPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG 954
            PP+    P  +  S+P   P     P  SS  FP P   P       P   A  T ++  
Sbjct: 293  PPSPGGLPVSEAPSLPAAQPAAKDSP--SSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGE 350

Query: 955  SPGKKTSKTSSPGGKKPP----PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAES 1010
                + +   SPG +  P      PQR          E PE +    D+  +   P   S
Sbjct: 351  EDAFEDAPRGSPGEEWAPEVGEDAPQRL--------GEEPEEEAQGPDAPAAASLP--GS 400

Query: 1011 GSPSKETLPP 1020
             +PS+    P
Sbjct: 401  PAPSQRCFKP 410



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 25/89 (28%), Positives = 32/89 (35%), Gaps = 10/89 (11%)

Query: 939  PPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP--PPTPQRNSSIKSSSGAEHPEPKRPS 996
            P  PP   SP P       +     S   G+ P  P T Q  S++     +   EP+ P 
Sbjct: 232  PAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQ 291

Query: 997  VDSLVSKFTPPAESGSPSKETLPPPAAPP 1025
                     PP+  G P  E    PAA P
Sbjct: 292  --------QPPSPGGLPVSEAPSLPAAQP 312



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 53/232 (22%), Positives = 71/232 (30%), Gaps = 51/232 (21%)

Query: 681 GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQF 740
           GA   P +P   Q+ S    +   P  +   P  P  PP+PG       P   APSLP  
Sbjct: 259 GAGEAPGSPDTEQALSALSDL---PESLAAEPREPQQPPSPGGL-----PVSEAPSLP-- 308

Query: 741 SAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPP---------QAPPKPLVTIPAPTST 791
            A  P  K       +  A P P   P   A   P         +         P  +  
Sbjct: 309 -AAQPAAK----DSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPG 363

Query: 792 KTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPP 851
           +  AP V + AP           + P  PA+   P  P P               C KP 
Sbjct: 364 EEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAP------------SQRCFKPY 411

Query: 852 PSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPK 903
           P      P  +K    Q   P   P+             +P   P +K +P+
Sbjct: 412 P---LITPCYIKTTTRQLSSPNHSPSQ------------SPNQSPRIKRRPE 448


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  174 bits (441), Expect = 5e-43
 Identities = 195/726 (26%), Positives = 258/726 (35%), Gaps = 173/726 (23%)

Query: 528  SLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAG------HVRSQSIVSSVFSE-- 579
            SLS    K   +++  P   S     + S V+   P G         + S+V+  F +  
Sbjct: 840  SLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEG 899

Query: 580  ----AWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPP- 634
                A K+   L  +S +  ++   P    +P  SP PK         P+PP   PP P 
Sbjct: 900  PATPAPKQAPALSMTSSSPKKARATPAPKGIPA-SPSPK-------GAPTPPAATPPSPK 951

Query: 635  -PPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQ 693
              P  P P   P PP  +  +P  G A P                  GA    PTPP   
Sbjct: 952  GGPATPSPKWAPTPPAATPPSPKGGPATP---------------SPKGA----PTPPAAT 992

Query: 694  SQSVKPQILVP-PNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQV 752
              S K     P P G   PP   PP P         K +P A   P+ ++ PP       
Sbjct: 993  PPSPKGGPATPSPKGAPTPPAVTPPSP---------KGSPAATPFPKGASTPP------- 1036

Query: 753  QHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVP- 811
                  A P  P   P   PLP  AP  P  T+P+P        +     PP  TPP P 
Sbjct: 1037 -----AATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPK 1091

Query: 812  -----PAKKQPAFPASYIPPSP----PTPP----VPVPPPTLPKQQSFCAKPPP--SPLS 856
                 P+ K    P +  PPSP     TPP       P  T P  +   A PPP  +P +
Sbjct: 1092 GGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTT 1151

Query: 857  PVPSVVKQIASQFPPPP---------TPPAMESQPLKPVPANVAPQSPPAVKAKPKW--- 904
            P  +          PPP         TPP+ +     P P   AP +P A    PK    
Sbjct: 1152 PAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKG-APTTPAATPPSPKGGLA 1210

Query: 905  --QPSSIPVPSPDFPPPPPESSLVFPPP---PPSPVPAPPPP------PPPTASPTPDKS 953
               P   P  +P   PP P+  L  P P   P +P   PP P      PPP  +PTP  +
Sbjct: 1211 TPSPKGAPT-TPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAA 1269

Query: 954  GSPGKKTSKTSSP--GGKKP----PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPP 1007
              P  K    + P  G   P    PP+P+   +     GA  P              TPP
Sbjct: 1270 TPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA-----------TPP 1318

Query: 1008 AESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSP 1067
            +  GSP   T PP  AP  P       V  P    +G  +  A   S +G       P+ 
Sbjct: 1319 SPKGSPG--TPPPKGAPTPP------AVTPPS--PKGTPTLPATTPSSKGG------PTT 1362

Query: 1068 PSDSDFPPPPPETE--------LPLPPIEIPAVFSGN---TSPKVAVVNPQ--------- 1107
            PS  + P PP  T          P  P   PA+ S     TSP V  ++P+         
Sbjct: 1363 PSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTR 1422

Query: 1108 ------------PQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
                        P   + +S+KKAP  + PK   +T  ++ +    PT+  V P  P  P
Sbjct: 1423 EGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGD----PTLPAVTPPSPKEP 1478

Query: 1156 KSSLSV 1161
             +   V
Sbjct: 1479 PAPKQV 1484



 Score =  164 bits (415), Expect = 5e-40
 Identities = 196/760 (25%), Positives = 258/760 (33%), Gaps = 104/760 (13%)

Query: 532  SSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESS 591
            SS  S   +S +PE+  +     DS  +   P       +   S  +    +G  L    
Sbjct: 825  SSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKE 884

Query: 592  KARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPP---PPPPPPPPPPPPP 648
                  +N P+     P +P PK     + +  SP      P P   P  P P   P PP
Sbjct: 885  TPTPSVVNLPFPK-EGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPP 943

Query: 649  LPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVP-PNG 707
              +  +P  G A P   K++                  PTPP     S K     P P G
Sbjct: 944  AATPPSPKGGPATPS-PKWA------------------PTPPAATPPSPKGGPATPSPKG 984

Query: 708  VVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP 767
               PP   PP P  G A    K AP  P++   S    P      +  +     TPP P 
Sbjct: 985  APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPK 1044

Query: 768  PIPA--PLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIP 825
              PA  PLP  AP  P  T+P+P        +     PP  TPP P  K  PA P+    
Sbjct: 1045 GSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSP--KGGPATPSPKGA 1102

Query: 826  PSPP--TPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPP---PTPPAMES 880
            P PP  TPP P      P  +     P  +P SP   +        PPP   PT PA   
Sbjct: 1103 PMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLAT------PPPKGAPTTPA--- 1153

Query: 881  QPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPV-PAPP 939
                       P SP    A P   P   P  +P   PP P+  L  P P  +P  PA  
Sbjct: 1154 ---------ATPPSPKGGLATPP--PKGAPT-TPAATPPSPKGGLATPSPKGAPTTPAAT 1201

Query: 940  PPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDS 999
            PP P     TP   G+P    +   SP G    P+P+      ++  A  P PK      
Sbjct: 1202 PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK---GAPTTPAATPPSPKG----- 1253

Query: 1000 LVSKFTPPAESGSPSKETLPPP------AAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVL 1053
                 TPP + G+P+     PP      A PP  G  N + V  P    +G  +   P  
Sbjct: 1254 --GPATPPPK-GAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPS--PKGGPATSPP-- 1306

Query: 1054 SGRGKDSVVEFPSPPSDSDFPPP-----PPETELPLP------PIEIPAVFSGNTSPKVA 1102
             G         PSP      PPP     PP    P P      P   P+   G T+P   
Sbjct: 1307 KGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSK 1366

Query: 1103 VVNPQPQQWSKMSVKKAPPPTRPKR--------NDSTRLTQAEISEQPTMATVVPQVPTS 1154
                 P          A  P  PKR         D T      +S +   AT V +   +
Sbjct: 1367 EGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAA 1426

Query: 1155 PKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQ 1214
              S   + P  +  ++      +    G  ++  S+ +PT        PP P E  + +Q
Sbjct: 1427 TPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTL---PAVTPPSPKEPPAPKQ 1483

Query: 1215 KAGYGGSHISGYATLRRGPP------PAPPKRDQNTKLSR 1248
             A       +       G P      P+ PK    T  SR
Sbjct: 1484 VATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSR 1523



 Score =  160 bits (406), Expect = 5e-39
 Identities = 186/701 (26%), Positives = 242/701 (34%), Gaps = 109/701 (15%)

Query: 601  PYTSLVPPLSPQPKIVTP-----YTASQPSPPLP--PPPPPPPPPP-------------- 639
            P  +L  P+SP      P     +  S+ SP     P PP P   P              
Sbjct: 820  PIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVT 879

Query: 640  -PPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVK 698
             PP   P P + +   P  G A P   +   ++   ++ + + A   P   P   S    
Sbjct: 880  LPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPS---- 935

Query: 699  PQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQV 758
                  P G   PP   PP P  G A    K AP  P     +A PP  K        + 
Sbjct: 936  ------PKGAPTPPAATPPSPKGGPATPSPKWAPTPP-----AATPPSPKGGPATPSPKG 984

Query: 759  APPTPPPPPPIP-----APLPPQAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPP 812
            AP  P   PP P      P P  AP  P VT P+P  +    P    A+ PP  TPP P 
Sbjct: 985  APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSP- 1043

Query: 813  AKKQPAFPASYIPPSPPTPPVPVPP-----PTLPKQQSFCAKPPPSPLSPV--PSVVKQI 865
             K  PA  A+ +P   PT P    P     P  P  +     P  +P SP   P+     
Sbjct: 1044 -KGSPA--ATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100

Query: 866  ASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKW-----QPSSIPVPSPDFPPPP 920
             +  PP  TPP+ +     P P   AP +P A    PK       P   P  +P   PP 
Sbjct: 1101 GAPMPPAATPPSPKGGLATP-PHKGAPTTPAATPPSPKGGLATPPPKGAPT-TPAATPPS 1158

Query: 921  PESSLVFPPPPPSP-VPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNS 979
            P+  L  PPP  +P  PA  PP P     TP   G+P    +   SP G    P+P+   
Sbjct: 1159 PKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK--- 1215

Query: 980  SIKSSSGAEHPEPK------RPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLS 1033
               ++  A  P PK       P         TPP+  G P+  T PP  AP  P      
Sbjct: 1216 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPA--TPPPKGAPTPPAA---- 1269

Query: 1034 GVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVF 1093
                P  L+ G  +   P   G    +VV   +PPS    P   P    P PP   P   
Sbjct: 1270 ---TPPSLKGGLAT---PPHKGAPNPAVV---TPPSPKGGPATSPPKGAPTPPAATPPSP 1320

Query: 1094 SGNTSPKVAVVNPQPQQWSKMSVKKAP--PPTRPKRNDSTRLTQAEISEQPTMATVVP-- 1149
             G+         P P   +  S K  P  P T P        T     E PT     P  
Sbjct: 1321 KGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGP--TTPSSKEGPTPPAATPSH 1378

Query: 1150 -----QVPTSPKSSLSV--------QPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTAT 1196
                   P SPK   ++         P  +    +      +TR G+ +       P A 
Sbjct: 1379 KGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPA- 1437

Query: 1197 MDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAP 1237
            +  ++L   P    +   K G       G  TL    PP+P
Sbjct: 1438 VTPVSLKKAP---ATSAPKGGPATPSSKGDPTLPAVTPPSP 1475



 Score =  150 bits (378), Expect = 1e-35
 Identities = 165/652 (25%), Positives = 227/652 (34%), Gaps = 114/652 (17%)

Query: 601  PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPS--AG 658
            P T    P SP+  + TP     P+ P   PP P   P  PPP   P  P+ + PS   G
Sbjct: 1218 PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGG 1277

Query: 659  SAAPMFVKYSTITRLQNASQHSGALFKPP----TPPVMQSQSVKPQILVPPNGVVPPPPP 714
             A P          +   S   G    PP    TPP     S K     PP    P PP 
Sbjct: 1278 LATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPA 1337

Query: 715  PPPP-----PTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPI 769
              PP     PT  +     K  P  PS  +   PP     H+      + PP+P   P I
Sbjct: 1338 VTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGG--PAMTPPSPKRGPAI 1395

Query: 770  PAPL------------PPQAPPKPLVTIPAPTSTK------TVAPVVTQAAPPTPTPP-- 809
            P+P             P +AP  P+    A T +K       V PV  + AP T  P   
Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGG 1455

Query: 810  --VPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIAS 867
               P +K  P  PA     +PP+P      P  PKQ +  + P  +P +P P     + +
Sbjct: 1456 PATPSSKGDPTLPAV----TPPSPK----EPPAPKQVATSSSPKKAPATPAPMGAPTLPA 1507

Query: 868  QFPPP----PTPPAMESQPLKP--------VPANVAPQS---PPAVKAKPKWQPSSIPVP 912
              P      P  P+    P+ P         PA +AP+    PPA+      +  +IP P
Sbjct: 1508 VIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTP 1567

Query: 913  --SPDFP-------PP----------PPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKS 953
              +P  P       PP          P    L+ PP   SP P   P PP    P+P+K 
Sbjct: 1568 KEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKG 1627

Query: 954  -GSPGKKTSKTS---SPGGKKPPPTPQRNSSIKSSSGAEHPE-----PKRPSVDSLVSKF 1004
              +P  K + TS   +P   K  PT    +S+    GA  P+     P +    +L    
Sbjct: 1628 PATPAPKGTPTSPPVTPSSLKDSPTSP--ASVTCKMGATVPQASKGLPAKKGPTALKEVL 1685

Query: 1005 TPPAESGSP------------SKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPV 1052
              PA   +P             K +   P   P P   N S     G L     +   PV
Sbjct: 1686 VAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGS----KGPLSTVAPAPLLPV 1741

Query: 1053 LSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWS 1112
                 K +  +  S        PP  +   PL       V      P+ A V+  P    
Sbjct: 1742 QKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVL---PKPESASVSAAPSPPV 1798

Query: 1113 KMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMA-------TVVPQVPTSPKS 1157
             + +  +P PT P +      +   + E P+          ++P +P  P S
Sbjct: 1799 SLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPIS 1850



 Score =  117 bits (293), Expect = 7e-26
 Identities = 160/657 (24%), Positives = 228/657 (34%), Gaps = 99/657 (15%)

Query: 644  PPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILV 703
            P     P +SA  AG A       ST T   +          P   PV +       ++ 
Sbjct: 643  PTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVP 702

Query: 704  PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCA---PSLPQFSAPPPPLKIHQVQHITQVAP 760
              +   P  P P     P + +      P +   PSLP    PP   K+  + H + +AP
Sbjct: 703  TASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAP 762

Query: 761  PTPPPP--PPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPA 818
                P   P   +     A  K  +T  A + +    P+    +P T  PP    KK  A
Sbjct: 763  VASSPKECPTEDSGASATASSKGTLTYLADSPS----PLGVSVSPQTKRPPT---KKGSA 815

Query: 819  FPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM 878
                     P TP   +  P  P + SF    P + LS   S      +  P PP+P   
Sbjct: 816  --------GPDTPIGNLSSPVSPVEASFL---PENSLSFQGSKDSPATTHSPTPPSPKGA 864

Query: 879  ESQPLKPVPANVAPQSPPAVKAKPKWQPS----SIPVPSPDFPPPPPESSLVF------- 927
                  P P+ V P SP  V   PK  P+    ++P P      P P+ +          
Sbjct: 865  ------PTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSP 918

Query: 928  ----PPPPPSPVPAPPPP---PPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSS 980
                  P P  +PA P P   P P A+  P   G P   + K +       PP+P+   +
Sbjct: 919  KKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPA 978

Query: 981  IKSSSGAEHPE----------PKRPSVDSLVS--KFTPPAESGSPSKETLP-----PPAA 1023
              S  GA  P           P  PS     +    TPP+  GSP+    P     PPAA
Sbjct: 979  TPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAA 1038

Query: 1024 PPKPGKLNLSGVNLPGVLQQGCVSAKAPVL----SGRGKDSVVEFP-----SPPSDSDFP 1074
             P   K + +   LP    +G  +  A  L     G    S+   P     +PPS    P
Sbjct: 1039 TPPSPKGSPAATPLP----KGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGP 1094

Query: 1075 PPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPP------PTRPKRN 1128
              P     P+PP   P       SPK  +  P P + +  +    PP       T P + 
Sbjct: 1095 ATPSPKGAPMPPAATP------PSPKGGLATP-PHKGAPTTPAATPPSPKGGLATPPPKG 1147

Query: 1129 DSTRLTQAEISEQPTMATVVPQ-VPTSPKSSLSVQPGFLADLN-----RTLQRKSITRHG 1182
              T       S +  +AT  P+  PT+P ++     G LA  +      T      +  G
Sbjct: 1148 APTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG 1207

Query: 1183 SLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPK 1239
             L++   +  PT      A PP P   L+     G   +  +   + + GP   PPK
Sbjct: 1208 GLATPSPKGAPTT---PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPK 1261



 Score =  108 bits (271), Expect = 2e-23
 Identities = 131/490 (26%), Positives = 177/490 (36%), Gaps = 94/490 (19%)

Query: 585  TQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPP-- 642
            T   +   A   S   P    V P SP+        A+  SP   P  P P   P  P  
Sbjct: 1449 TSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAV 1508

Query: 643  -PPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQI 701
             P  P  +P+  +      AP                 +  L    TP  +  +    + 
Sbjct: 1509 IPSSPKEVPATPSSRRDPIAP-----------------TATLLSKKTPATLAPK----EA 1547

Query: 702  LVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPP 761
            L+PP   VP P   P  PTP       K AP  PS  + S+PP       V   T    P
Sbjct: 1548 LIPPAMTVPSPKKTPAIPTP-------KEAPATPSSKEASSPP------AVTPSTYKGAP 1594

Query: 762  TPPP---PPPIPAPLPPQAPPKPLVT---------IPAPTSTKTVAPVVTQAAPPTPTPP 809
            +P     PP + +P P +AP  P VT          PAP  T T  PV   +   +PT P
Sbjct: 1595 SPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSP 1654

Query: 810  ----------VP------PAKKQP-AFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPP 852
                      VP      PAKK P A     + P+P + P+ +  PT    Q+  +    
Sbjct: 1655 ASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPI-ITAPTRKGPQTKKSSATS 1713

Query: 853  SPLSPVPSV---VKQIASQFPPPPTPPAME--SQPLKPVPANVAPQSPPAVKAKPKWQPS 907
             P+ P PS     K   S   P P  P  +  S+  K   A+ +P+ P A    P    +
Sbjct: 1714 PPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLA----PPESKA 1769

Query: 908  SIPVPSPDFP---PPPPESSLVFPPPPPSPVP-APPPPP--PPTASPTPDKSGSPGKKTS 961
            S P+ +  F    P P  +S+   P PP  +P AP P P  PP     P   G   +  S
Sbjct: 1770 STPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPS 1829

Query: 962  KTSSPGGKKP-----PPTPQRNSSIKSSSGAEHPEPK-------RPSVDSLVSKFTPPAE 1009
            K  +P  +       PP P        S     P PK        PS    V+K    + 
Sbjct: 1830 KPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSG 1889

Query: 1010 SGSPSKETLP 1019
            + S S E++P
Sbjct: 1890 TESDSDESVP 1899



 Score =  107 bits (268), Expect = 5e-23
 Identities = 123/472 (26%), Positives = 171/472 (36%), Gaps = 106/472 (22%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPP------------PPPPPPLPSQSAP 655
            P +  PK      +S+  P LP   PP P  PP P            P  P P+ + + P
Sbjct: 1447 PATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLP 1506

Query: 656  SAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP 715
            +   ++P  V  +  +R ++    +  L    TP  +  +    + L+PP   VP P   
Sbjct: 1507 AVIPSSPKEVPATPSSR-RDPIAPTATLLSKKTPATLAPK----EALIPPAMTVPSPKKT 1561

Query: 716  PPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPP---PPPIPAP 772
            P  PTP       K AP  PS  + S+PP       V   T    P+P     PP + +P
Sbjct: 1562 PAIPTP-------KEAPATPSSKEASSPPA------VTPSTYKGAPSPKELLIPPAVTSP 1608

Query: 773  LPPQAPPKPLVT---------IPAPTSTKTVAPVVTQAAPPTPTPP----------VP-- 811
             P +AP  P VT          PAP  T T  PV   +   +PT P          VP  
Sbjct: 1609 SPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQA 1668

Query: 812  ----PAKKQP-AFPASYIPPSPPTPPVPVPPPTLPKQ--QSFCAKPP------------- 851
                PAKK P A     + P+P + P+   P     Q  +S    PP             
Sbjct: 1669 SKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKG 1728

Query: 852  ------PSPLSPVPSVVKQIA-----SQFPPPPTPP--AMESQPLK--------PVPANV 890
                  P+PL PV     + A     S  P  P  P  +  S PL         P P + 
Sbjct: 1729 PLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESA 1788

Query: 891  APQSPPAVKAKPKWQPSSIPV--PSPDFPPPPPESSLVFPPPPPSPVP----APPPPPPP 944
            +  + P+        PS +P   P   F P  P   L  P  P +P       P  PP P
Sbjct: 1789 SVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEP 1848

Query: 945  TASPTPDKSGSPGKKTSKTS-----SPGGKKPPPTPQRNSSIKSSSGAEHPE 991
             +   P +S      T K++     +P  K+P     + S  +S S    PE
Sbjct: 1849 ISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPE 1900



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 133/591 (22%), Positives = 206/591 (34%), Gaps = 92/591 (15%)

Query: 623  QPSPPLPPP-PPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSG 681
            QP P LPPP  P P   P        P PS   PS  ++ P+ V +      Q++S  + 
Sbjct: 40   QPGPTLPPPCSPAPQQCPLSAANQASPFPS---PSTIASTPLEVPFP-----QSSSGTAL 91

Query: 682  ALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGS----AMAQLKPAPCAPSL 737
             L   P  P      + P I      +  P   P    TP S    A+  L P     S 
Sbjct: 92   PLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSS 151

Query: 738  ---PQFSAPPPPLKIHQVQHITQVAPPTPPPPPP----------IPAPLPPQAPPKPLVT 784
               P     PP + + +   +  ++ P  P  P           +P P    +PP  + T
Sbjct: 152  AFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVST 211

Query: 785  IP-----APTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPP---TPPVPVP 836
            +P        S ++    + Q  P T      P  K     +  I P  P   +   PV 
Sbjct: 212  VPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVS 271

Query: 837  PPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPV------PANV 890
            PP         A    +   PV +  ++ A    PP  P ++ S  L P+         +
Sbjct: 272  PP--------AALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSH-LAPLHQSSFGSVQL 322

Query: 891  APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTP 950
              Q+ P+  + P  +  S+   S      P + S++ P P  + V        P  +P+ 
Sbjct: 323  LGQTGPSALSDPTVKTISVDHSSTG-ASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSV 381

Query: 951  DKSGSPGKKTSKTSSPGGKKPPPT-----PQRNSSIKSSSGAEHPEP---KRP--SVDSL 1000
            DK   P   +S T SP G     T     P  +  +KSS  A +  P   + P  SV + 
Sbjct: 382  DK--GPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTT 439

Query: 1001 VSKFTPP---AESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
                T P   A + + + E     + P   G ++      P  L    V+ K P      
Sbjct: 440  PLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEP---STQ 496

Query: 1058 KDSVVEFPSPPSDSDFPPPPPETELPLPP---IEIPAVFSGNTSPKVAVVNPQPQQWSKM 1114
              + +  P  P     P P PE    LP    ++ P      T P      P     + +
Sbjct: 497  VATTLRIPVSP-----PLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGL 551

Query: 1115 SVKKAPP-----PTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLS 1160
            + KK P         PK + S + T +            P++P SP+++L+
Sbjct: 552  TTKKDPTVLPLVQAAPKNSPSFQSTSSS-----------PEIPLSPEATLA 591



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 117/512 (22%), Positives = 168/512 (32%), Gaps = 75/512 (14%)

Query: 737  LPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAP 796
            LPQ  A    L +     +T       P  PP  +P P Q P           S  T+A 
Sbjct: 16   LPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIAS 75

Query: 797  VVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCA-------K 849
               +        P P +    A P    P +P   P  + PP  P   +  +       K
Sbjct: 76   TPLEV-------PFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLK 128

Query: 850  PPPSPLSPVPSVV-----KQIASQFPP-----PPTPPAMESQPLKPVPANVAPQSPPAVK 899
              PS  +P+  V       Q +S FPP     PP+    ES  +  + A +AP  P   K
Sbjct: 129  GTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEP---K 185

Query: 900  AKPKWQPSSIPVPSPDFPPPPPESSLVFP---PPPPSPVPAPPPPPPPTASPTPDKSGSP 956
                  PS + VP+P   P PP      P     P + + +     P T   T     SP
Sbjct: 186  TNLNKVPSEV-VPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASP 244

Query: 957  GKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKE 1016
              K +  SS        +PQ   S+ S  G   P    P+  SL ++  P   S   +  
Sbjct: 245  QVKDTTISS-----VLISPQNPGSL-SLKGPVSP----PAALSLSTQSLPVVTSSQKTAG 294

Query: 1017 TLPPPAAPPKPG-------KLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPS 1069
               PP  P   G       + +   V L G  Q G  +   P +     D      S PS
Sbjct: 295  PNTPPDFPISLGSHLAPLHQSSFGSVQLLG--QTGPSALSDPTVKTISVDHSSTGASYPS 352

Query: 1070 DSDFPPPPPETELPLP------PIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPT 1123
                 PP P     +P      P+  P+V  G ++  ++ +   P     ++   +  PT
Sbjct: 353  QRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPST--ISSITCSPSGSLNVATSFSLSPT 410

Query: 1124 RPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQP-------GFLADLNRTLQRK 1176
                      T   +   P      P V   P SS+   P          A    T +  
Sbjct: 411  ----------TSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVA 460

Query: 1177 SITRHGSLSSRMSRAEPTATMDDMALPPPPPE 1208
            +       S  +S  EPT+    +  P  P E
Sbjct: 461  TCVSPPMSSGPISNIEPTSPAALVMAPVAPKE 492



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 107/465 (23%), Positives = 163/465 (35%), Gaps = 87/465 (18%)

Query: 769  IPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSP 828
            +PA       P+    +   +S  +V   + Q  P  P P  P  ++ P   A+   P P
Sbjct: 9    VPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFP 68

Query: 829  PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPA------MESQP 882
                +   P  +P  QS  +     PL   P     + +   PP +P A      M +  
Sbjct: 69   SPSTIASTPLEVPFPQS--SSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPT 126

Query: 883  LKPVPANVAP-----QSPPAVKAKPKWQPSSIPVP--------------SPDFPPPPPES 923
            LK  P++ AP      +P +V+    + P+ +  P              S    P  P++
Sbjct: 127  LKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKT 186

Query: 924  SLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKS 983
            +L   P    P P   P PP   S  P    +P    +   S     P  TP    +I S
Sbjct: 187  NLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTP---MASIQSGVASLPQTTPTTTLAIAS 243

Query: 984  SSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSG-VNLPGVLQ 1042
                  P+ K  ++ S++                     +P  PG L+L G V+ P  L 
Sbjct: 244  ------PQVKDTTISSVL--------------------ISPQNPGSLSLKGPVSPPAALS 277

Query: 1043 QGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAV-FSGNTSP-- 1099
                S   PV++   K +      P +  DFP        PL      +V   G T P  
Sbjct: 278  LSTQS--LPVVTSSQKTA-----GPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSA 330

Query: 1100 ------KVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPT 1153
                  K   V+      S  S +   PP  P RN+   +  A ++  P +A  V + P+
Sbjct: 331  LSDPTVKTISVDHSSTGASYPSQRSVIPPL-PSRNE---VVPATVAAFPVVAPSVDKGPS 386

Query: 1154 -------SPKSSLSVQPGFLADLNRTLQRKS---ITRHGSLSSRM 1188
                   SP  SL+V   F      +L  KS    T H  L ++M
Sbjct: 387  TISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQM 431



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 138/614 (22%), Positives = 186/614 (30%), Gaps = 150/614 (24%)

Query: 682  ALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPA----PCAPSL 737
            A F    P V +  S    I   P+G +         PT    +     A    P    +
Sbjct: 372  AAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQM 431

Query: 738  PQFSAPPPPLKIHQVQHITQVAPPTPP-------PPPPIPAPLPPQAPPKPLVTIPAPT- 789
            P  S    PL +      T  A PT          PP    P+    P  P   + AP  
Sbjct: 432  PVSSVGTTPLVV--TNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVA 489

Query: 790  ----STKTVAPVVTQAAPPTPTP------------PVPPAKKQPAFPASY--IPPSP--- 828
                ST+    +    +PP P P              P  K     PAS    P SP   
Sbjct: 490  PKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQA 549

Query: 829  -------PT--PPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQ-IASQFP-------- 870
                   PT  P V   P   P  QS  +  P  PLSP  ++ K+ +    P        
Sbjct: 550  GLTTKKDPTVLPLVQAAPKNSPSFQS-TSSSPEIPLSPEATLAKKSLGEPLPIGKPASSM 608

Query: 871  --------------------PPPTPPAMESQPLKPV----------PANVAP-------- 892
                                P    P ++S  + P           PA VAP        
Sbjct: 609  TSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTST 668

Query: 893  ---QSPPAVKAKPKWQPSSIPVPSPDFP-----PPPPESSLVFPPPPPSPVP------AP 938
                + P ++      P + PV           P   E+  V P P  +  P      AP
Sbjct: 669  YTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAP 728

Query: 939  ------PPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSG------ 986
                  P P  P A   P      G   +   +P    P   P  +S   +++       
Sbjct: 729  EIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLT 788

Query: 987  --AEHPEPKRPSVDSLVSKFTPPAESGSPSKET----LPPPAAPPKPGKLNLSGVNLPGV 1040
              A+ P P   SV     +  PP + GS   +T    L  P +P +   L  + ++  G 
Sbjct: 789  YLADSPSPLGVSVSPQTKR--PPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGS 846

Query: 1041 LQQGCV--SAKAPVLSGRGKDSVVEFPSPPSDSDFP----PPPPETELPLP--------P 1086
                    S   P   G    S V  P  P     P    P P    LP P        P
Sbjct: 847  KDSPATTHSPTPPSPKGAPTPSAVT-PLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAP 905

Query: 1087 IEIPAVFSGNTSPKVAVVNPQPQQW-SKMSVKKAPPP---TRPKRNDSTRLTQAEISEQP 1142
             + PA+   ++SPK A   P P+   +  S K AP P   T P           + +  P
Sbjct: 906  KQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP 965

Query: 1143 TMATVVPQVPTSPK 1156
              AT     P SPK
Sbjct: 966  PAAT-----PPSPK 974



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 69/304 (22%), Positives = 105/304 (34%), Gaps = 27/304 (8%)

Query: 826  PSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTP-----PAMES 880
            P   T  VP     LP+ Q+  A  P S    V + + Q     PPP +P     P   +
Sbjct: 2    PGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAA 61

Query: 881  QPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPP-ESSLVFPPPPPSPVPAPP 939
                P P+     S P     P+   S   +P    P  P    +L+ PP  P+ +    
Sbjct: 62   NQASPFPSPSTIASTPLEVPFPQ-SSSGTALPLGTAPEAPTFLPNLIGPPISPAALALAS 120

Query: 940  PPPPPTASPTPDKSG-------SPGKKTSKTSSPGG---KKPPPTPQRNSSIKSSSGAEH 989
            P   PT   TP  S        +P      ++ P       P      + S+ + S    
Sbjct: 121  PMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIA 180

Query: 990  PEPKRPSVDSLVSKFTPPAESGSPSK----ETLPPPAAPPKPGKLNLSGVNLPGVLQQGC 1045
            P   + +++ + S+  P  + G+PS      T+P     P    +     +LP       
Sbjct: 181  PSEPKTNLNKVPSEVVPNPK-GTPSPPCIVSTVPYHCVTPM-ASIQSGVASLPQTTPTTT 238

Query: 1046 VSAKAPVLSGRGKDSVVEFPSPPSDSDFP-PPPPETELPLPPIEIPAVFSGNTSPKVAVV 1104
            ++  +P +      SV+  P  P       P  P   L L    +P V S   S K A  
Sbjct: 239  LAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTS---SQKTAGP 295

Query: 1105 NPQP 1108
            N  P
Sbjct: 296  NTPP 299


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score =  169 bits (428), Expect = 2e-41
 Identities = 199/759 (26%), Positives = 270/759 (35%), Gaps = 160/759 (21%)

Query: 531  SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFS--EAWKRGTQLE 588
            SS  +SG S+   P + ++ S     G+   +P      +   +       +    T   
Sbjct: 250  SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 309

Query: 589  ESSKAR-MESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPP 647
              +KAR +   +   T L   L P P + TP   + PSP  PP     P PP  PP   P
Sbjct: 310  SGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAP 369

Query: 648  PL----PSQSAPSAGSAAPMFVKYS-TITRLQ--------NASQHSGALFKPPTPPVMQS 694
            P     P Q+ PS  +  P+ V +S T   LQ        ++ Q + +L  P        
Sbjct: 370  PSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSF 429

Query: 695  QSVKPQ----ILVPPNGVVPPPPPPPP----------PPTPGSAMAQLKP---------- 730
             ++ P+     L  P+     PP  PP          PP   S    + P          
Sbjct: 430  LTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPL 489

Query: 731  ---------APCAP---------------SLPQFSAPPPPLKIHQVQHITQVAPP----- 761
                     +P AP               + P    PP  L    ++++  +APP     
Sbjct: 490  QALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTA 549

Query: 762  ----TPP--PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 815
                T P    PP PAP P QAPP PL T P P +  ++A    QA P   +PP+     
Sbjct: 550  SAPLTTPHLETPPCPAPCPLQAPPSPLTT-PPPETPSSIATPPPQAPPALASPPLQGLPS 608

Query: 816  QPAFPASYIPPSPPTPPVPVP----PPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPP 871
             P  P +  PP  P P + +P    PP+ P          PSP +P    V  + + F P
Sbjct: 609  PPLSPLATPPPQAP-PXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 667

Query: 872  PPTPPAM------ESQPLKP--VPANVAP--------QSPPAVKAKPKWQPSSIPVPSPD 915
            PP+PP         S P+ P   P + AP        Q PP+  A P   PS+   P P 
Sbjct: 668  PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA--TPPPQ 725

Query: 916  FPPPPPESSLVFPPPPPSPVP----APPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP 971
             PPP     L  PP PP+  P    A PPP  P     P     P    S   SP  K P
Sbjct: 726  APPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP 785

Query: 972  P--------------PTPQRN---------SSIKSSSGAEHPEPKRPSVDSLVSKFTPPA 1008
            P              P+P  +         S+    S    P P+ P V +      PP+
Sbjct: 786  PQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPS 845

Query: 1009 ESGSPSKETLPPPAAPPKPG-KLNLSGVNLPGVLQQG---------CVSAKAPVLSGRGK 1058
               SP   TL  P  PP PG   ++SG  L   L  G           +   P L+G   
Sbjct: 846  PPASP---TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 902

Query: 1059 ------DSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAV--VNPQPQQ 1110
                  + +  + S P       PPP+ EL       PA +S   +P +A       P  
Sbjct: 903  SATSTPEELRGYDSGPEGGAAASPPPDAELAACH---PAAWSRGPAPPLAFRGAPGAPLP 959

Query: 1111 WSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVP 1149
            W        PP T P   D   L     +E P  AT  P
Sbjct: 960  W--------PPATGPGSADG--LCTIYETEGPESATPAP 988



 Score =  164 bits (416), Expect = 4e-40
 Identities = 172/564 (30%), Positives = 219/564 (38%), Gaps = 118/564 (20%)

Query: 587  LEESSKARMESMNRPYTSLV-PPLSPQPKIVTP--YTASQP--SPPLPPPPPPPP----P 637
            LE  S     S+  P  SL  PPL   P +  P   TAS P  +P L  PP P P     
Sbjct: 512  LETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQA 571

Query: 638  PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSV 697
            PP P   PPP  PS  A     A P                 S  L   P+PP+    + 
Sbjct: 572  PPSPLTTPPPETPSSIATPPPQAPPALA--------------SPPLQGLPSPPLSPLATP 617

Query: 698  KPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQ 757
             PQ   PP   +PP   PP PP          P+P AP+          L +H +Q    
Sbjct: 618  PPQ--APPXLALPPLQAPPSPPASPPLSPLATPSPQAPNA---------LAVHLLQ---- 662

Query: 758  VAPPTPPPPPPIPAPL-PPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQ 816
             AP +PPP PP+ AP  PP +PP       +P++T       + AAPP   PP PPA   
Sbjct: 663  -APFSPPPSPPVQAPFSPPASPPV------SPSATPPSQAPPSLAAPPLQVPPSPPASP- 714

Query: 817  PAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPP 876
            P  P++  PP  P PP+  PP  +P      A PP SP            S  PPP  PP
Sbjct: 715  PMSPSATPPPQAP-PPLAAPPLQVPPSPP--ASPPMSP------------SATPPPRVPP 759

Query: 877  AMESQPLKPVP-----------ANVAPQSPPAVKAKP----KWQPSSIPVPSPDFPPPP- 920
             + + PL+  P           A   PQ+PPA+   P       P+S P  +P  P    
Sbjct: 760  LLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 819

Query: 921  PESSLVFPPPPPSPVPAPP---PPPPPTASPT---PDKSGSPGKKTSKTSSP-------G 967
            P S L  PPP   PV A P    PP P ASPT   P +  +PG  TS  S P        
Sbjct: 820  PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS-VSGPRLTLALAP 878

Query: 968  GKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKP 1027
            G  PPP+   +S++     A H      + + L    + P    + S    PPP A    
Sbjct: 879  GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAAS----PPPDA---- 930

Query: 1028 GKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSD---------FPPPPP 1078
                L+  + P    +G     AP L+ RG       P PP+            +    P
Sbjct: 931  ---ELAACH-PAAWSRG----PAPPLAFRGAPG-APLPWPPATGPGSADGLCTIYETEGP 981

Query: 1079 ETELPLPPIEIPAVFSGNTSPKVA 1102
            E+  P P    P    G +  K A
Sbjct: 982  ESATPAPGALDPGPSPGTSGGKAA 1005



 Score =  150 bits (379), Expect = 7e-36
 Identities = 208/816 (25%), Positives = 281/816 (34%), Gaps = 192/816 (23%)

Query: 536  SGSSSSSIPESQSNHSNQSDSG-VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKAR 594
            SG    + P   ++    S  G  S T   G +  + +  S   E   RG   E   ++ 
Sbjct: 97   SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA-EETVARGKATEAPKRSA 155

Query: 595  MESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP---------- 644
            + +  R  TS   P +P P +     A+     LP P P   P PP   P          
Sbjct: 156  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 215

Query: 645  ----PPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSG--------ALFKPPTPPVM 692
                P P    + +   G   P     S+     ++   SG        A   P  P   
Sbjct: 216  STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPK 275

Query: 693  QSQSVKPQILVPPNGVVPP---PPPPPPPPTPGSAMAQLKPAP----CAPSLPQFSAPPP 745
              Q+++P  + PP     P   P    P  TP  +  + +P P     A  LP    P P
Sbjct: 276  GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSP 335

Query: 746  PLKIHQVQHITQVAPPTPPPPPPIPA-PLPPQAPPK---PLVTIP---APTSTKTVAPVV 798
            PL          +APP+P  PP +   P PP  PP    P +T P   AP S +T+ P+ 
Sbjct: 336  PLATP-----LPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQ 390

Query: 799  TQAAPPTPTPPVPPAK-----------------------------------KQPAFPASY 823
               +  +P+   PP+                                      P+ PAS 
Sbjct: 391  VPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAST 450

Query: 824  IPPSPP-TPPVPVP-PPTLPKQQSFCAKPPPSPLSPVP-SVVKQIASQFPPPP-----TP 875
             P SPP   P+ +P  P L    S    P  SPL+  P   +  +AS  P  P      P
Sbjct: 451  PPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMP 510

Query: 876  PAMESQPLKPVPANVAPQS---PPAVK----AKPKWQPSSIPVPSPDFPPPP-------- 920
            P      L P      P S   PP       A P  Q +S P+ +P    PP        
Sbjct: 511  PLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQ 570

Query: 921  -PESSLVFPPP-PPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP------- 971
             P S L  PPP  PS +  PPP  PP A  +P   G P    S  ++P  + P       
Sbjct: 571  APPSPLTTPPPETPSSIATPPPQAPP-ALASPPLQGLPSPPLSPLATPPPQAPPXLALPP 629

Query: 972  ---PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPG 1028
               PP+P  +  +   +      P   +V  L + F+PP     P +    PPA+PP   
Sbjct: 630  LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP--PSPPVQAPFSPPASPP--- 684

Query: 1029 KLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPP---PPPETELPL- 1084
               +S    P    Q   S  AP L           PSPP+     P   PPP+   PL 
Sbjct: 685  ---VSPSATPP--SQAPPSLAAPPLQVP--------PSPPASPPMSPSATPPPQAPPPLA 731

Query: 1085 -PPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPT 1143
             PP+++P               P P     MS    PPP  P                P 
Sbjct: 732  APPLQVP---------------PSPPASPPMSPSATPPPRVP----------------PL 760

Query: 1144 MATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPT-ATMDDMAL 1202
            +A    QVP SP +SL + P                    L+    +A P  AT    AL
Sbjct: 761  LAAPPLQVPPSPPASLPMSP--------------------LAKPPPQAPPALATPPLQAL 800

Query: 1203 PPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPP 1238
            P PP    S   +A +  S     + L   PP APP
Sbjct: 801  PSPP---ASFPGQAPFSPSASLPMSPLATPPPQAPP 833



 Score =  123 bits (309), Expect = 1e-27
 Identities = 155/628 (24%), Positives = 235/628 (37%), Gaps = 79/628 (12%)

Query: 632  PPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPV 691
            P PP  P PPPP  P  L    A  A    P+          + A    GA      P  
Sbjct: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPL---------AERAGGIGGATIPESAPRA 77

Query: 692  MQSQSV-----KPQILVPPNGVVPPPPP-----PPPPPTPGSAMAQLKPAPCAPSLPQFS 741
              ++S       P    P +G     PP     P P  +PG A    +P P      + S
Sbjct: 78   GPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 137

Query: 742  APP----------PPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTS- 790
            A            P             + PTP  P P  A     A  +  +  PAP++ 
Sbjct: 138  AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSAR 197

Query: 791  ----TKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSF 846
                T+     V+ A+  + T P P A+++P+       P+  +      P + P +   
Sbjct: 198  PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 257

Query: 847  CAKPPP-SPLSPVPSVVKQIASQFPPPPTPPAMESQP-LKPVPAN-VAPQSPPAVKAKPK 903
             A+  P +P  P     K + +  PP  TPP  ++ P L P+ ++ +A  SP   KA+P 
Sbjct: 258  SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPV 317

Query: 904  WQPSSIPVPSPDFPPPPPESSLVFPPPPPSP--------VPAPPPPPPPTASP---TPDK 952
              P +   P P   PP P  +   P  PPSP        +P+PP  PP  A P   TP  
Sbjct: 318  PPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPM 377

Query: 953  SGSPGKKT-------SKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFT 1005
               P  +T          +SP   + PP+P   SS+++++    P  +       +S   
Sbjct: 378  QAPPSLQTIPPIQVPHSLTSP-SLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQ 436

Query: 1006 PPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFP 1065
              A   SPS+    PP +PP    L+L        LQ     A +P+ S      +    
Sbjct: 437  TQASLTSPSRPASTPPDSPPLQAPLSLPA---SPPLQTSLSPAVSPLSSPLTIHPLQALS 493

Query: 1066 SPPSDSDFPPPPPETELPLPPIEIPAVFSGNT--SPKVAVVNPQPQQWSKMSVKKAPPPT 1123
            S  S S   P  P + L +PP+E  +  +  +  +P  ++  P  +    +    APPP 
Sbjct: 494  SLASHS---PQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSL----APPPL 546

Query: 1124 RPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGS 1183
               +  S  LT   +   P  A    Q P SP   L+  P    +   ++         +
Sbjct: 547  ---QTASAPLTTPHLETPPCPAPCPLQAPPSP---LTTPP---PETPSSIATPPPQAPPA 597

Query: 1184 LSSRMSRAEPTATMDDMALPPP--PPEL 1209
            L+S   +  P+  +  +A PPP  PP L
Sbjct: 598  LASPPLQGLPSPPLSPLATPPPQAPPXL 625



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 111/462 (24%), Positives = 154/462 (33%), Gaps = 105/462 (22%)

Query: 842  KQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM----------------------- 878
            K ++  A   P+  +P     +   S  PPPP  PA                        
Sbjct: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66

Query: 879  -----ESQP----------LKPVPANVAPQSPPAVKAKPKWQPSSIPVPSP------DFP 917
                 ES P              PA+  P S    +A P    S  PV SP        P
Sbjct: 67   GATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP 126

Query: 918  PP----------------------PPESSL-------VFPPPPPSPVPAPP--------- 939
             P                      P  S+L          P P +P PA           
Sbjct: 127  GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 186

Query: 940  ---PPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPS 996
               P P P+A P P   G P K  S  S     +P P  +R    + S+G     P   S
Sbjct: 187  VGLPRPAPSARPRPPTEG-PRKSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRS 241

Query: 997  VDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGR 1056
            + S  +  + PA SG  ++ T   PA P +P    L  +  P V         AP L G 
Sbjct: 242  LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR--KDAAPAL-GP 298

Query: 1057 GKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSV 1116
               S +  PSP      P PPP+      P  +P   S   +  + +  P P     +  
Sbjct: 299  LSSSPLATPSPSGTKARPVPPPDNAATPLPATLPP--SPPLATPLPLAPPSPSAPPSLQT 356

Query: 1117 KKAPPPTRPKRNDSTRLTQAEISEQPTMATVVP-QVP---TSPKSSLSVQPGFLADLNRT 1172
              +PP T P +   + +T   +   P++ T+ P QVP   TSP       P  L+ L  T
Sbjct: 357  LPSPPATPPSQAPPS-MTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQAT 415

Query: 1173 LQRKSITRHG-----SLSSRMSRAEPTATMDDMALPPPPPEL 1209
                S T        ++S R ++A  T+     + PP  P L
Sbjct: 416  TSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPL 457


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  168 bits (426), Expect = 3e-41
 Identities = 182/713 (25%), Positives = 266/713 (37%), Gaps = 106/713 (14%)

Query: 518  KRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVF 577
            ++T SA +  S+  +S K  + +S +    +  +  +  G + T P     +        
Sbjct: 168  EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPT-------- 219

Query: 578  SEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPP 637
                   T  E +S    E    P T    P +P+    T   ++  +P  P P     P
Sbjct: 220  -------TPKEPASTTPKEPT--PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP 270

Query: 638  PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSV 697
             P  P  P P    + AP+   +AP   K                   P TP      + 
Sbjct: 271  APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA----------------PTTPKKPAPTTP 314

Query: 698  KPQILVPPNGVVPPPPPPPPPPTPGSAMAQLK-PAPCAPSLPQFSAPPPPLKIHQVQHIT 756
            K      P    P  P  P P T   A    K PAP AP  P  + P  P          
Sbjct: 315  KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP---------- 364

Query: 757  QVAPPTPPPPPPI----PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP 812
              AP TP  P P     P+P  P+  P P  T  APT+TK  AP  T++AP TP  P P 
Sbjct: 365  --APTTPKEPAPTTTKEPSPTTPK-EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT 421

Query: 813  AKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFP-- 870
              K+PA P +   P+P TP  P   PT PK+ +     P +P  P P+  K+ A   P  
Sbjct: 422  TTKEPA-PTTPKEPAPTTPKKPA--PTTPKEPA-----PTTPKEPAPTTTKKPAPTTPKE 473

Query: 871  PPPTPPAMESQPLKP------VPANVAPQSP--PAVKAKPKWQPSSIPVPSPDFP--PPP 920
            P PT P  E+ P  P       P  +AP +P  PA     +  P++   P+P  P  P P
Sbjct: 474  PAPTTP-KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAP 532

Query: 921  PESSLVFPPPPPSPVPAPPPPPPPTA--SPTPDKSGSPGKKTSKTSSPGG-KKPPPTPQR 977
                   P  P  P P  P  P PT    P P         T K ++P   K+P PT  +
Sbjct: 533  TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPK 592

Query: 978  NSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGV-- 1035
              + K  +     EP   + D   +  TP   + +  KE  P P  P +P      G   
Sbjct: 593  KPAPKELAPTTTKEPTSTTCDK-PAPTTPKGTAPTTPKE--PAPTTPKEPAPTTPKGTAP 649

Query: 1036 -----NLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIP 1090
                   P   ++      AP  +     +  + P+P +  +  P  P+   P  P + P
Sbjct: 650  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP-KKP 708

Query: 1091 AVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATV--- 1147
            A  +  T P      P   + S  +  K P       ++ST     E+S +PT   +   
Sbjct: 709  APTTPETPP------PTTSEVSTPTTTKEPTTIHKSPDEST----PELSAEPTPKALENS 758

Query: 1148 --VPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMD 1198
               P VPT+ K+  + +P    ++  T + K+  R    +   + A P  T +
Sbjct: 759  PKEPGVPTT-KTPAATKP----EMTTTAKDKTTERDLRTTPETTTAAPKMTKE 806



 Score =  154 bits (388), Expect = 7e-37
 Identities = 164/663 (24%), Positives = 242/663 (36%), Gaps = 83/663 (12%)

Query: 614  KIVTPYTASQPSPPLPPPPP---PPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTI 670
            K+ TP T++     +   P      P  P P  PP      +++ +      +  K +T 
Sbjct: 98   KVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 157

Query: 671  TRLQNASQHSGALFKPPTPPVMQSQSVKP---QILVPPNGVVPPPPPPPPPPTPGSAMAQ 727
            T  Q ++       K  T    ++QS++    + L P + V+  P P     T G A+  
Sbjct: 158  TNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT 212

Query: 728  LK-PAPCAPSLPQFSAP--PPPLKIHQVQHI--------TQVAPPTPPPPPPI----PAP 772
             K P P  P  P  + P  P P  I              T+ AP TP  P P     PAP
Sbjct: 213  PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 272

Query: 773  LPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPP 832
              P+ P       PAPT+TK+      + AP TP  P P   K+PA P +   P+P TP 
Sbjct: 273  TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPTPTTPK 331

Query: 833  VPVPP-----PTLPKQQSFCA--KPPPS-PLSPVPSVVKQIA---SQFPPPPTPPAMESQ 881
             P P      PT PK+ +  A  KP P+ P  P P+  K+ A   ++ P P TP      
Sbjct: 332  EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 391

Query: 882  PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPP 941
              K  P      +P   K+ P       P  + +  P  P+      P  P+P     P 
Sbjct: 392  TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 451

Query: 942  PPPTASPTPDKSGSPGKKTSKTSSPGGKK--PPPTPQRNSSIKSSSGAEHPEPKRPSVDS 999
            P     P P  +  P   T K  +P   K   P TP++ +          PE   P+   
Sbjct: 452  PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT-------PEKLAPTTPE 504

Query: 1000 LVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKD 1059
              +  TP  E  +P+    P P  P +P          P           AP        
Sbjct: 505  KPAPTTP--EELAPTTPEEPTPTTPEEPAP------TTPKAAAPNTPKEPAPTTPKEPAP 556

Query: 1060 SVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKK- 1118
            +  + P+P +  +  P  P+   P   ++ PA     T+PK     P P++ +  + K+ 
Sbjct: 557  TTPKEPAPTTPKETAPTTPKGTAP-TTLKEPA----PTTPK----KPAPKELAPTTTKEP 607

Query: 1119 ------APPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRT 1172
                   P PT PK       T     ++P   T     PT+PK +    P  L +   T
Sbjct: 608  TSTTCDKPAPTTPKG------TAPTTPKEPAPTTPKEPAPTTPKGT---APTTLKEPAPT 658

Query: 1173 LQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRG 1232
              +K   +  + ++      PT+T  D   P  P E      K     +      T    
Sbjct: 659  TPKKPAPKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPET 715

Query: 1233 PPP 1235
            PPP
Sbjct: 716  PPP 718



 Score =  147 bits (371), Expect = 6e-35
 Identities = 159/649 (24%), Positives = 231/649 (35%), Gaps = 81/649 (12%)

Query: 601  PYTSLVP-PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGS 659
            P T+  P P + +    TP   +  +P  P P  P  P P  P  P P  P + AP+   
Sbjct: 280  PTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKE 339

Query: 660  AAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPP 719
             AP   K    T  +  +  +     P TP      + K      P    P      P  
Sbjct: 340  PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 399

Query: 720  TPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPI----PAPLPP 775
            T   A    K AP  P  P  +    P            AP TP  P P     PAP  P
Sbjct: 400  TKEPAPTTTKSAPTTPKEPSPTTTKEP------------APTTPKEPAPTTPKKPAPTTP 447

Query: 776  QAPPKPLVTIPAPTSTKTVAPVV-TQAAPPTP--TPPVPPAKKQPAFPASYIPPSPPTPP 832
            + P       PAPT+TK  AP    + AP TP  T P  P K  P  P   + P+ P  P
Sbjct: 448  KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK-LAPTTPEKP 506

Query: 833  VPVPP----PTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTP-------PAMESQ 881
             P  P    PT P++ +     P +P  P P+  K  A   P  P P       P    +
Sbjct: 507  APTTPEELAPTTPEEPT-----PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 561

Query: 882  PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPPPPS-----P 934
            P    P   AP +P          P+++  P+P  P  P P E +      P S     P
Sbjct: 562  PAPTTPKETAPTTPKGT------APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 615

Query: 935  VPAPPPPPPPTA--SPTPDKSGSPGKKTSKTSSPGG-KKPPPTPQRNSSIKSSSGAEHPE 991
             P  P    PT    P P     P   T K ++P   K+P PT  +  + K  +      
Sbjct: 616  APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG 675

Query: 992  PKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKL-------NLSGVNLPGVLQQG 1044
            P   + D      T P E+ +P+    P P  P KP            S V+ P   ++ 
Sbjct: 676  PTSTTSDKPAP--TTPKET-APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEP 732

Query: 1045 CVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAV- 1103
                K+P       +S  E  + P+       P E    +P  + PA     T P++   
Sbjct: 733  TTIHKSP------DESTPELSAEPTPKALENSPKEP--GVPTTKTPAA----TKPEMTTT 780

Query: 1104 ----VNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSL 1159
                   +  + +  +   AP  T+     + + T+++I+   T  T      T+P    
Sbjct: 781  AKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKIT 840

Query: 1160 SVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPE 1208
            +++   LA    T  +K+IT    ++     A+P     +     P P+
Sbjct: 841  TLKTTTLAP-KVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQ 888



 Score =  144 bits (363), Expect = 5e-34
 Identities = 165/663 (24%), Positives = 236/663 (35%), Gaps = 108/663 (16%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP--PPPPLPSQSAPSAGSA-APMF 664
            P    PK  TP T  +P+P    P P  P  P P  P  P P  P + AP+     AP  
Sbjct: 317  PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 376

Query: 665  VKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA 724
             K           + S    K P P   +S     +   P      P  P  P PT    
Sbjct: 377  TK-----------EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 425

Query: 725  MAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLP-PQAPPKPLV 783
             A   P   AP+ P+  AP  P          + AP TP  P P     P P  P +P  
Sbjct: 426  PAPTTPKEPAPTTPKKPAPTTP---------KEPAPTTPKEPAPTTTKKPAPTTPKEPAP 476

Query: 784  TIP---APTSTKTVAPVVTQA-APPTPTPPVP--PAKKQPAFPASYIP-----PSPPTPP 832
            T P   APT+ K + P   +  AP TP  P P  P +  P  P    P     P+P TP 
Sbjct: 477  TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 536

Query: 833  VPV------PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME----SQP 882
                     P PT PK+ +     P +P  P P+  K+ A   P    P  ++    + P
Sbjct: 537  AAAPNTPKEPAPTTPKEPA-----PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 591

Query: 883  LKPVPANVAPQS----------PPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPP 930
             KP P  +AP +           PA        P++   P+P  P  P P       P  
Sbjct: 592  KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 651

Query: 931  PPSPVPAPPPPPPP-------TASPTPDKSGSPGKKTSKTSSP-GGKKPPPTPQRNSSIK 982
               P P  P  P P       T  PT   S  P   T K ++P   K+P PT  +     
Sbjct: 652  LKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK---P 708

Query: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
            + +  E P P    V +  +   P     SP + T P  +A P P  L  S    PGV  
Sbjct: 709  APTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST-PELSAEPTPKALENSPKE-PGVPT 766

Query: 1043 QGCVSAKAPVLSGRGKDSVVE---FPSPPSDSDFPPPPPET----------ELPLPPIEI 1089
                +A  P ++   KD   E     +P + +  P    ET          ++     ++
Sbjct: 767  TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 826

Query: 1090 PAVFSGNTSP------KVAVVNPQPQQWSK----MSVKKAPPPTRPKRNDSTRLTQAEIS 1139
             +  + +T+P      K   + P+     K      +   P  T   ++ +T       +
Sbjct: 827  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRAT--NSKATT 884

Query: 1140 EQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDD 1199
             +P   T  P+ PTS K   +        + R  + K+      ++S M    PT+ + +
Sbjct: 885  PKPQKPTKAPKKPTSTKKPKT--------MPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 936

Query: 1200 MAL 1202
              L
Sbjct: 937  AML 939



 Score =  134 bits (337), Expect = 5e-31
 Identities = 165/687 (24%), Positives = 236/687 (34%), Gaps = 96/687 (13%)

Query: 590  SSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL 649
            ++K+   +   P  +        PK  +P T  +P+P  P  P P  P  P P  P  P 
Sbjct: 392  TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 451

Query: 650  PSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVV 709
            P+    +    AP   K    T  +  +        P TP      + K      P  + 
Sbjct: 452  PT----TPKEPAPTTTKKPAPTTPKEPA--------PTTPKETAPTTPKKLTPTTPEKLA 499

Query: 710  PPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPI 769
            P  P  P P TP   +A   P    P+ P+  AP  P            AP TP  P P 
Sbjct: 500  PTTPEKPAPTTP-EELAPTTPEEPTPTTPEEPAPTTP---------KAAAPNTPKEPAPT 549

Query: 770  ----PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIP 825
                PAP  P+ P        APT+ K  AP  T    P PT P  PA K+ A P +   
Sbjct: 550  TPKEPAPTTPKEPAPTTPKETAPTTPKGTAP--TTLKEPAPTTPKKPAPKELA-PTTTKE 606

Query: 826  PSPPT--PPVPVPP----PTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME 879
            P+  T   P P  P    PT PK+ +     P +P  P P+  K  A      P P    
Sbjct: 607  PTSTTCDKPAPTTPKGTAPTTPKEPA-----PTTPKEPAPTTPKGTAPTTLKEPAP---- 657

Query: 880  SQPLKPVPANVAPQSP--PAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPA 937
            + P KP P  +AP +   P      K  P++    +P  P  P       P  P  P P 
Sbjct: 658  TTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA------PTTPKKPAPT 711

Query: 938  PPPPPPPTAS----PTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPK 993
             P  PPPT S    PT  K  +   K+   S+P      PTP+   +     G   P  K
Sbjct: 712  TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTP-ELSAEPTPKALENSPKEPGV--PTTK 768

Query: 994  RPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVL 1053
             P+      + T  A+  +  ++    P       K+            +  ++A    +
Sbjct: 769  TPAATK--PEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 826

Query: 1054 SGRGKDSVVEFP-SPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWS 1112
            +         F  +    +   P    T+  +   EI         PK    N      S
Sbjct: 827  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATN------S 880

Query: 1113 KMSVKKAPPPTR-PKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNR 1171
            K +  K   PT+ PK+  ST+  +     +    T  P+  TS    L+        + +
Sbjct: 881  KATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 940

Query: 1172 TLQRKSITRHGSLSSRMSRAE--------------------PTATMDDMALPPPPPE--- 1208
            T  R + T +  L     ++E                    P  T D   LP  P +   
Sbjct: 941  TTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGII 1000

Query: 1209 ---LLSDQQKAGYGGSHISGYATLRRG 1232
               +LSD+      G  + G  TLR G
Sbjct: 1001 INPMLSDETNI-CNGKPVDGLTTLRNG 1026


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  168 bits (426), Expect = 3e-41
 Identities = 182/713 (25%), Positives = 266/713 (37%), Gaps = 106/713 (14%)

Query: 518  KRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVF 577
            ++T SA +  S+  +S K  + +S +    +  +  +  G + T P     +        
Sbjct: 209  EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPT-------- 260

Query: 578  SEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPP 637
                   T  E +S    E    P T    P +P+    T   ++  +P  P P     P
Sbjct: 261  -------TPKEPASTTPKEPT--PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP 311

Query: 638  PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSV 697
             P  P  P P    + AP+   +AP   K                   P TP      + 
Sbjct: 312  APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA----------------PTTPKKPAPTTP 355

Query: 698  KPQILVPPNGVVPPPPPPPPPPTPGSAMAQLK-PAPCAPSLPQFSAPPPPLKIHQVQHIT 756
            K      P    P  P  P P T   A    K PAP AP  P  + P  P          
Sbjct: 356  KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP---------- 405

Query: 757  QVAPPTPPPPPPI----PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP 812
              AP TP  P P     P+P  P+  P P  T  APT+TK  AP  T++AP TP  P P 
Sbjct: 406  --APTTPKEPAPTTTKEPSPTTPK-EPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT 462

Query: 813  AKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFP-- 870
              K+PA P +   P+P TP  P   PT PK+ +     P +P  P P+  K+ A   P  
Sbjct: 463  TTKEPA-PTTPKEPAPTTPKKPA--PTTPKEPA-----PTTPKEPAPTTTKKPAPTTPKE 514

Query: 871  PPPTPPAMESQPLKP------VPANVAPQSP--PAVKAKPKWQPSSIPVPSPDFP--PPP 920
            P PT P  E+ P  P       P  +AP +P  PA     +  P++   P+P  P  P P
Sbjct: 515  PAPTTP-KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAP 573

Query: 921  PESSLVFPPPPPSPVPAPPPPPPPTA--SPTPDKSGSPGKKTSKTSSPGG-KKPPPTPQR 977
                   P  P  P P  P  P PT    P P         T K ++P   K+P PT  +
Sbjct: 574  TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPK 633

Query: 978  NSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGV-- 1035
              + K  +     EP   + D   +  TP   + +  KE  P P  P +P      G   
Sbjct: 634  KPAPKELAPTTTKEPTSTTCDK-PAPTTPKGTAPTTPKE--PAPTTPKEPAPTTPKGTAP 690

Query: 1036 -----NLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIP 1090
                   P   ++      AP  +     +  + P+P +  +  P  P+   P  P + P
Sbjct: 691  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP-KKP 749

Query: 1091 AVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATV--- 1147
            A  +  T P      P   + S  +  K P       ++ST     E+S +PT   +   
Sbjct: 750  APTTPETPP------PTTSEVSTPTTTKEPTTIHKSPDEST----PELSAEPTPKALENS 799

Query: 1148 --VPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMD 1198
               P VPT+ K+  + +P    ++  T + K+  R    +   + A P  T +
Sbjct: 800  PKEPGVPTT-KTPAATKP----EMTTTAKDKTTERDLRTTPETTTAAPKMTKE 847



 Score =  154 bits (388), Expect = 7e-37
 Identities = 164/663 (24%), Positives = 242/663 (36%), Gaps = 83/663 (12%)

Query: 614  KIVTPYTASQPSPPLPPPPP---PPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTI 670
            K+ TP T++     +   P      P  P P  PP      +++ +      +  K +T 
Sbjct: 139  KVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 198

Query: 671  TRLQNASQHSGALFKPPTPPVMQSQSVKP---QILVPPNGVVPPPPPPPPPPTPGSAMAQ 727
            T  Q ++       K  T    ++QS++    + L P + V+  P P     T G A+  
Sbjct: 199  TNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT 253

Query: 728  LK-PAPCAPSLPQFSAP--PPPLKIHQVQHI--------TQVAPPTPPPPPPI----PAP 772
             K P P  P  P  + P  P P  I              T+ AP TP  P P     PAP
Sbjct: 254  PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 313

Query: 773  LPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPP 832
              P+ P       PAPT+TK+      + AP TP  P P   K+PA P +   P+P TP 
Sbjct: 314  TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPTPTTPK 372

Query: 833  VPVPP-----PTLPKQQSFCA--KPPPS-PLSPVPSVVKQIA---SQFPPPPTPPAMESQ 881
             P P      PT PK+ +  A  KP P+ P  P P+  K+ A   ++ P P TP      
Sbjct: 373  EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPT 432

Query: 882  PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPP 941
              K  P      +P   K+ P       P  + +  P  P+      P  P+P     P 
Sbjct: 433  TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 492

Query: 942  PPPTASPTPDKSGSPGKKTSKTSSPGGKK--PPPTPQRNSSIKSSSGAEHPEPKRPSVDS 999
            P     P P  +  P   T K  +P   K   P TP++ +          PE   P+   
Sbjct: 493  PTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT-------PEKLAPTTPE 545

Query: 1000 LVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKD 1059
              +  TP  E  +P+    P P  P +P          P           AP        
Sbjct: 546  KPAPTTP--EELAPTTPEEPTPTTPEEPAP------TTPKAAAPNTPKEPAPTTPKEPAP 597

Query: 1060 SVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKK- 1118
            +  + P+P +  +  P  P+   P   ++ PA     T+PK     P P++ +  + K+ 
Sbjct: 598  TTPKEPAPTTPKETAPTTPKGTAP-TTLKEPA----PTTPK----KPAPKELAPTTTKEP 648

Query: 1119 ------APPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRT 1172
                   P PT PK       T     ++P   T     PT+PK +    P  L +   T
Sbjct: 649  TSTTCDKPAPTTPKG------TAPTTPKEPAPTTPKEPAPTTPKGT---APTTLKEPAPT 699

Query: 1173 LQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRG 1232
              +K   +  + ++      PT+T  D   P  P E      K     +      T    
Sbjct: 700  TPKKPAPKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPET 756

Query: 1233 PPP 1235
            PPP
Sbjct: 757  PPP 759



 Score =  147 bits (371), Expect = 6e-35
 Identities = 159/649 (24%), Positives = 231/649 (35%), Gaps = 81/649 (12%)

Query: 601  PYTSLVP-PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGS 659
            P T+  P P + +    TP   +  +P  P P  P  P P  P  P P  P + AP+   
Sbjct: 321  PTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKE 380

Query: 660  AAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPP 719
             AP   K    T  +  +  +     P TP      + K      P    P      P  
Sbjct: 381  PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 440

Query: 720  TPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPI----PAPLPP 775
            T   A    K AP  P  P  +    P            AP TP  P P     PAP  P
Sbjct: 441  TKEPAPTTTKSAPTTPKEPSPTTTKEP------------APTTPKEPAPTTPKKPAPTTP 488

Query: 776  QAPPKPLVTIPAPTSTKTVAPVV-TQAAPPTP--TPPVPPAKKQPAFPASYIPPSPPTPP 832
            + P       PAPT+TK  AP    + AP TP  T P  P K  P  P   + P+ P  P
Sbjct: 489  KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK-LAPTTPEKP 547

Query: 833  VPVPP----PTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTP-------PAMESQ 881
             P  P    PT P++ +     P +P  P P+  K  A   P  P P       P    +
Sbjct: 548  APTTPEELAPTTPEEPT-----PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 602

Query: 882  PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPPPPS-----P 934
            P    P   AP +P          P+++  P+P  P  P P E +      P S     P
Sbjct: 603  PAPTTPKETAPTTPKGT------APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 656

Query: 935  VPAPPPPPPPTA--SPTPDKSGSPGKKTSKTSSPGG-KKPPPTPQRNSSIKSSSGAEHPE 991
             P  P    PT    P P     P   T K ++P   K+P PT  +  + K  +      
Sbjct: 657  APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG 716

Query: 992  PKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKL-------NLSGVNLPGVLQQG 1044
            P   + D      T P E+ +P+    P P  P KP            S V+ P   ++ 
Sbjct: 717  PTSTTSDKPAP--TTPKET-APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEP 773

Query: 1045 CVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAV- 1103
                K+P       +S  E  + P+       P E    +P  + PA     T P++   
Sbjct: 774  TTIHKSP------DESTPELSAEPTPKALENSPKEP--GVPTTKTPAA----TKPEMTTT 821

Query: 1104 ----VNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSL 1159
                   +  + +  +   AP  T+     + + T+++I+   T  T      T+P    
Sbjct: 822  AKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKIT 881

Query: 1160 SVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPE 1208
            +++   LA    T  +K+IT    ++     A+P     +     P P+
Sbjct: 882  TLKTTTLAP-KVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQ 929



 Score =  144 bits (363), Expect = 5e-34
 Identities = 165/663 (24%), Positives = 236/663 (35%), Gaps = 108/663 (16%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP--PPPPLPSQSAPSAGSA-APMF 664
            P    PK  TP T  +P+P    P P  P  P P  P  P P  P + AP+     AP  
Sbjct: 358  PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 417

Query: 665  VKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA 724
             K           + S    K P P   +S     +   P      P  P  P PT    
Sbjct: 418  TK-----------EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 466

Query: 725  MAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLP-PQAPPKPLV 783
             A   P   AP+ P+  AP  P          + AP TP  P P     P P  P +P  
Sbjct: 467  PAPTTPKEPAPTTPKKPAPTTP---------KEPAPTTPKEPAPTTTKKPAPTTPKEPAP 517

Query: 784  TIP---APTSTKTVAPVVTQA-APPTPTPPVP--PAKKQPAFPASYIP-----PSPPTPP 832
            T P   APT+ K + P   +  AP TP  P P  P +  P  P    P     P+P TP 
Sbjct: 518  TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 577

Query: 833  VPV------PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME----SQP 882
                     P PT PK+ +     P +P  P P+  K+ A   P    P  ++    + P
Sbjct: 578  AAAPNTPKEPAPTTPKEPA-----PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 632

Query: 883  LKPVPANVAPQS----------PPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPP 930
             KP P  +AP +           PA        P++   P+P  P  P P       P  
Sbjct: 633  KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 692

Query: 931  PPSPVPAPPPPPPP-------TASPTPDKSGSPGKKTSKTSSP-GGKKPPPTPQRNSSIK 982
               P P  P  P P       T  PT   S  P   T K ++P   K+P PT  +     
Sbjct: 693  LKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK---P 749

Query: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
            + +  E P P    V +  +   P     SP + T P  +A P P  L  S    PGV  
Sbjct: 750  APTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST-PELSAEPTPKALENSPKE-PGVPT 807

Query: 1043 QGCVSAKAPVLSGRGKDSVVE---FPSPPSDSDFPPPPPET----------ELPLPPIEI 1089
                +A  P ++   KD   E     +P + +  P    ET          ++     ++
Sbjct: 808  TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 867

Query: 1090 PAVFSGNTSP------KVAVVNPQPQQWSK----MSVKKAPPPTRPKRNDSTRLTQAEIS 1139
             +  + +T+P      K   + P+     K      +   P  T   ++ +T       +
Sbjct: 868  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRAT--NSKATT 925

Query: 1140 EQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDD 1199
             +P   T  P+ PTS K   +        + R  + K+      ++S M    PT+ + +
Sbjct: 926  PKPQKPTKAPKKPTSTKKPKT--------MPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 977

Query: 1200 MAL 1202
              L
Sbjct: 978  AML 980



 Score =  134 bits (337), Expect = 5e-31
 Identities = 165/687 (24%), Positives = 236/687 (34%), Gaps = 96/687 (13%)

Query: 590  SSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL 649
            ++K+   +   P  +        PK  +P T  +P+P  P  P P  P  P P  P  P 
Sbjct: 433  TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA 492

Query: 650  PSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVV 709
            P+    +    AP   K    T  +  +        P TP      + K      P  + 
Sbjct: 493  PT----TPKEPAPTTTKKPAPTTPKEPA--------PTTPKETAPTTPKKLTPTTPEKLA 540

Query: 710  PPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPI 769
            P  P  P P TP   +A   P    P+ P+  AP  P            AP TP  P P 
Sbjct: 541  PTTPEKPAPTTP-EELAPTTPEEPTPTTPEEPAPTTP---------KAAAPNTPKEPAPT 590

Query: 770  ----PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIP 825
                PAP  P+ P        APT+ K  AP  T    P PT P  PA K+ A P +   
Sbjct: 591  TPKEPAPTTPKEPAPTTPKETAPTTPKGTAP--TTLKEPAPTTPKKPAPKELA-PTTTKE 647

Query: 826  PSPPT--PPVPVPP----PTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME 879
            P+  T   P P  P    PT PK+ +     P +P  P P+  K  A      P P    
Sbjct: 648  PTSTTCDKPAPTTPKGTAPTTPKEPA-----PTTPKEPAPTTPKGTAPTTLKEPAP---- 698

Query: 880  SQPLKPVPANVAPQSP--PAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPA 937
            + P KP P  +AP +   P      K  P++    +P  P  P       P  P  P P 
Sbjct: 699  TTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA------PTTPKKPAPT 752

Query: 938  PPPPPPPTAS----PTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPK 993
             P  PPPT S    PT  K  +   K+   S+P      PTP+   +     G   P  K
Sbjct: 753  TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTP-ELSAEPTPKALENSPKEPGV--PTTK 809

Query: 994  RPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVL 1053
             P+      + T  A+  +  ++    P       K+            +  ++A    +
Sbjct: 810  TPAATK--PEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 867

Query: 1054 SGRGKDSVVEFP-SPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWS 1112
            +         F  +    +   P    T+  +   EI         PK    N      S
Sbjct: 868  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATN------S 921

Query: 1113 KMSVKKAPPPTR-PKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNR 1171
            K +  K   PT+ PK+  ST+  +     +    T  P+  TS    L+        + +
Sbjct: 922  KATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 981

Query: 1172 TLQRKSITRHGSLSSRMSRAE--------------------PTATMDDMALPPPPPE--- 1208
            T  R + T +  L     ++E                    P  T D   LP  P +   
Sbjct: 982  TTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGII 1041

Query: 1209 ---LLSDQQKAGYGGSHISGYATLRRG 1232
               +LSD+      G  + G  TLR G
Sbjct: 1042 INPMLSDETNI-CNGKPVDGLTTLRNG 1067


>gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]
          Length = 540

 Score =  159 bits (401), Expect = 2e-38
 Identities = 99/278 (35%), Positives = 146/278 (52%), Gaps = 9/278 (3%)

Query: 269 KKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFE 328
           KK VI+V+  D++S+ + V    T R V   L+ K+H      W+L E +  + +ER  E
Sbjct: 106 KKQVIKVYSEDETSRALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIE 165

Query: 329 DHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEV---LL 385
           DHE ++E L NW  + +NKL F +   KY  FKNP  Y   +   +   + N E+    +
Sbjct: 166 DHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPM-YFFPEHMVSFATETNGEISPTQI 224

Query: 386 EECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQL 445
            + F  SS T PEI G L  K+ GKKSWKK YF LR SG+Y+  KG +K  R L  F + 
Sbjct: 225 LQMFLSSS-TYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEF 283

Query: 446 DHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKY 505
            + ++Y     + K+ APT+Y    K P      + +K LC ++ ++   WV  IR+ KY
Sbjct: 284 GNSDIYVSLAGKKKHGAPTNYGFCFK-PNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKY 342

Query: 506 GKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSI 543
           G QLY NY    +        +S S S ++S S +S +
Sbjct: 343 GMQLYQNYMHPYQGRSGC---SSQSISPMRSISENSLV 377


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  159 bits (401), Expect = 2e-38
 Identities = 178/740 (24%), Positives = 273/740 (36%), Gaps = 92/740 (12%)

Query: 542  SIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRP 601
            S+ E+Q + S+ S S  S T      + +S  +S  +   ++  +++++ K R +    P
Sbjct: 118  SVSENQESSSSSSSSSSSSTIR----KIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTP 173

Query: 602  YTSLVPPLSP-----QPKIVTPYTASQPSPPLPPPPP---PPPPPPPPPPPPPPPLPSQS 653
               +V            K+ TP T++     +   P      P  P P  PP      ++
Sbjct: 174  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 233

Query: 654  APSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKP---QILVPPNGVVP 710
            + +      +  K +T T  Q ++       K  T    ++QS++    + L P + V+ 
Sbjct: 234  SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 288

Query: 711  PPPPPPPPPTPGSAMAQLK-PAPCAPSLPQFSAP--PPPLKIHQVQHI--------TQVA 759
             P P     T G A+   K P P  P  P  + P  P P  I              T+ A
Sbjct: 289  KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 348

Query: 760  PPTPPPPPPI----PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 815
            P TP  P P     PAP  P+ P       PAPT+TK+      + AP TP  P P   K
Sbjct: 349  PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 408

Query: 816  QPAFPASYIPPSPPTPPVPVPP-----PTLPKQQSFCA--KPPPS-PLSPVPSVVKQIA- 866
            +PA P +   P+P TP  P P      PT PK+ +  A  KP P+ P  P P+  K+ A 
Sbjct: 409  EPA-PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 467

Query: 867  --SQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESS 924
              ++ P P TP        K  P      +P   K+ P       P  + +  P  P+  
Sbjct: 468  TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 527

Query: 925  LVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKK--PPPTPQRNSSIK 982
                P  P+P     P P     P P  +  P   T K  +P   K   P TP++ +   
Sbjct: 528  APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 587

Query: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
                   PE   P+     +  TP  E  +P+    P P  P +P          P    
Sbjct: 588  -------PEKLAPTTPEKPAPTTP--EELAPTTPEEPTPTTPEEPAP------TTPKAAA 632

Query: 1043 QGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVA 1102
                   AP        +  + P+P +  +  P  P+   P   ++ PA     T+PK  
Sbjct: 633  PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP-TTLKEPA----PTTPK-- 685

Query: 1103 VVNPQPQQWSKMSVKK-------APPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
               P P++ +  + K+        P PT PK       T     ++P   T     PT+P
Sbjct: 686  --KPAPKELAPTTTKEPTSTTCDKPAPTTPKG------TAPTTPKEPAPTTPKEPAPTTP 737

Query: 1156 KSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQK 1215
            K +    P  L +   T  +K   +  + ++      PT+T  D   P  P E      K
Sbjct: 738  KGT---APTTLKEPAPTTPKKPAPKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPK 791

Query: 1216 AGYGGSHISGYATLRRGPPP 1235
                 +      T    PPP
Sbjct: 792  EPAPTTPKKPAPTTPETPPP 811



 Score =  144 bits (363), Expect = 5e-34
 Identities = 165/663 (24%), Positives = 236/663 (35%), Gaps = 108/663 (16%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP--PPPPLPSQSAPSAGSA-APMF 664
            P    PK  TP T  +P+P    P P  P  P P  P  P P  P + AP+     AP  
Sbjct: 410  PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 469

Query: 665  VKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA 724
             K           + S    K P P   +S     +   P      P  P  P PT    
Sbjct: 470  TK-----------EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 518

Query: 725  MAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLP-PQAPPKPLV 783
             A   P   AP+ P+  AP  P          + AP TP  P P     P P  P +P  
Sbjct: 519  PAPTTPKEPAPTTPKKPAPTTP---------KEPAPTTPKEPAPTTTKKPAPTTPKEPAP 569

Query: 784  TIP---APTSTKTVAPVVTQA-APPTPTPPVP--PAKKQPAFPASYIP-----PSPPTPP 832
            T P   APT+ K + P   +  AP TP  P P  P +  P  P    P     P+P TP 
Sbjct: 570  TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 629

Query: 833  VPV------PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME----SQP 882
                     P PT PK+ +     P +P  P P+  K+ A   P    P  ++    + P
Sbjct: 630  AAAPNTPKEPAPTTPKEPA-----PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 684

Query: 883  LKPVPANVAPQS----------PPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPP 930
             KP P  +AP +           PA        P++   P+P  P  P P       P  
Sbjct: 685  KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 744

Query: 931  PPSPVPAPPPPPPP-------TASPTPDKSGSPGKKTSKTSSP-GGKKPPPTPQRNSSIK 982
               P P  P  P P       T  PT   S  P   T K ++P   K+P PT  +     
Sbjct: 745  LKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK---P 801

Query: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
            + +  E P P    V +  +   P     SP + T P  +A P P  L  S    PGV  
Sbjct: 802  APTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST-PELSAEPTPKALENSPKE-PGVPT 859

Query: 1043 QGCVSAKAPVLSGRGKDSVVE---FPSPPSDSDFPPPPPET----------ELPLPPIEI 1089
                +A  P ++   KD   E     +P + +  P    ET          ++     ++
Sbjct: 860  TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 919

Query: 1090 PAVFSGNTSP------KVAVVNPQPQQWSK----MSVKKAPPPTRPKRNDSTRLTQAEIS 1139
             +  + +T+P      K   + P+     K      +   P  T   ++ +T       +
Sbjct: 920  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRAT--NSKATT 977

Query: 1140 EQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDD 1199
             +P   T  P+ PTS K   +        + R  + K+      ++S M    PT+ + +
Sbjct: 978  PKPQKPTKAPKKPTSTKKPKT--------MPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 1029

Query: 1200 MAL 1202
              L
Sbjct: 1030 AML 1032



 Score =  104 bits (260), Expect = 5e-22
 Identities = 148/649 (22%), Positives = 219/649 (33%), Gaps = 90/649 (13%)

Query: 635  PPPPPPPPPPPPPPLPSQSAPSAGSAAPM---------------FVKYSTITRLQNASQH 679
            P  PP     PPP   SQ+  S    +P                  +  +++  Q +S  
Sbjct: 69   PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 128

Query: 680  SGALFKPPTPPVMQS-------QSVKPQILVPPNGV-VPPPPPPPPPPTPGSAMAQLKPA 731
            S +     T   ++S       + ++ ++ V  N        P P PP    A + L   
Sbjct: 129  SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 188

Query: 732  PCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQA--PPKPLVTIPAPT 789
                + P  S      K+     IT   P  P P       LPP +    +  +T+   T
Sbjct: 189  DFKVTTPDTSTTQHN-KVSTSPKITTAKPINPRP------SLPPNSDTSKETSLTVNKET 241

Query: 790  STKTVAPVVTQAAPPTP-TPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCA 848
            + +T     T     T        AK+  +   +      PT  V   P   PK ++   
Sbjct: 242  TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP--TPKAETTTK 299

Query: 849  KPP-PSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKP-VPANVAPQSPPAVKAKPKWQP 906
             P   +P  P P+  K+ AS  P  PTP  ++S P  P  PA    +S P    +P   P
Sbjct: 300  GPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEP--AP 357

Query: 907  SSIPVPSPDFP---------PPPPESSLVFPPPPPSPVPAPPPPPPPTA--SPTPDKSGS 955
            ++   P+P  P          P P ++   P  P  P P  P  P PT    P P     
Sbjct: 358  TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 417

Query: 956  PGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSK 1015
            P   T K  +P  K+P PT  +  +  +        PK P      +  TP   + + +K
Sbjct: 418  PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP------APTTPKEPAPTTTK 471

Query: 1016 ETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPP 1075
            E  P P  P +P                   +  AP        +  + P+P +  +  P
Sbjct: 472  E--PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 529

Query: 1076 PPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQ 1135
              P+   P  P E PA     T+PK     P P      +  K P PT PK         
Sbjct: 530  TTPKKPAPTTPKE-PA----PTTPK----EPAP------TTTKKPAPTTPK--------- 565

Query: 1136 AEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTA 1195
                 +P   T     PT+PK      P  LA    T ++ + T    L+   +  EPT 
Sbjct: 566  -----EPAPTTPKETAPTTPKKLTPTTPEKLAP--TTPEKPAPTTPEELAP-TTPEEPTP 617

Query: 1196 TMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQNT 1244
            T  +   P  P     +  K     +      T  + P P  PK    T
Sbjct: 618  TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 666



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 68/320 (21%), Positives = 102/320 (31%), Gaps = 47/320 (14%)

Query: 608  PLSPQPKIVTPYT--------ASQPSPPLPP---PPPPPPPPPPPPPPPPPPLPSQSAPS 656
            P  P PK + P T        + +P+P  P    P  P  P P  P  P P  P    P+
Sbjct: 753  PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT 812

Query: 657  AGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPP 716
                +         T  ++  + +  L   PTP  +++   +P +   P    P    P 
Sbjct: 813  TSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGV---PTTKTPAATKPE 869

Query: 717  PPPTPGSAMAQ--LKPAP----CAPSLPQFSAPPPPLKIHQ--VQHITQVAPPTPPPPPP 768
               T      +  L+  P     AP + + +A               TQV   T     P
Sbjct: 870  MTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 929

Query: 769  IPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSP 828
                         + T+     T T+AP VT       T  +    ++ A P      S 
Sbjct: 930  F-----------KITTL----KTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSK 974

Query: 829  PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPA 888
             T P P  P   PK+ +   KP   P    P             PTP  M S   +  P 
Sbjct: 975  ATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT----------PTPRKMTSTMPELNPT 1024

Query: 889  NVAPQSPPAVKAKPKWQPSS 908
            +   ++      +P   P+S
Sbjct: 1025 SRIAEAMLQTTTRPNQTPNS 1044


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  159 bits (401), Expect = 2e-38
 Identities = 178/740 (24%), Positives = 273/740 (36%), Gaps = 92/740 (12%)

Query: 542  SIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRP 601
            S+ E+Q + S+ S S  S T      + +S  +S  +   ++  +++++ K R +    P
Sbjct: 159  SVSENQESSSSSSSSSSSSTIR----KIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTP 214

Query: 602  YTSLVPPLSP-----QPKIVTPYTASQPSPPLPPPPP---PPPPPPPPPPPPPPPLPSQS 653
               +V            K+ TP T++     +   P      P  P P  PP      ++
Sbjct: 215  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 274

Query: 654  APSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKP---QILVPPNGVVP 710
            + +      +  K +T T  Q ++       K  T    ++QS++    + L P + V+ 
Sbjct: 275  SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 329

Query: 711  PPPPPPPPPTPGSAMAQLK-PAPCAPSLPQFSAP--PPPLKIHQVQHI--------TQVA 759
             P P     T G A+   K P P  P  P  + P  P P  I              T+ A
Sbjct: 330  KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 389

Query: 760  PPTPPPPPPI----PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 815
            P TP  P P     PAP  P+ P       PAPT+TK+      + AP TP  P P   K
Sbjct: 390  PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 449

Query: 816  QPAFPASYIPPSPPTPPVPVPP-----PTLPKQQSFCA--KPPPS-PLSPVPSVVKQIA- 866
            +PA P +   P+P TP  P P      PT PK+ +  A  KP P+ P  P P+  K+ A 
Sbjct: 450  EPA-PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 508

Query: 867  --SQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESS 924
              ++ P P TP        K  P      +P   K+ P       P  + +  P  P+  
Sbjct: 509  TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 568

Query: 925  LVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKK--PPPTPQRNSSIK 982
                P  P+P     P P     P P  +  P   T K  +P   K   P TP++ +   
Sbjct: 569  APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 628

Query: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
                   PE   P+     +  TP  E  +P+    P P  P +P          P    
Sbjct: 629  -------PEKLAPTTPEKPAPTTP--EELAPTTPEEPTPTTPEEPAP------TTPKAAA 673

Query: 1043 QGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVA 1102
                   AP        +  + P+P +  +  P  P+   P   ++ PA     T+PK  
Sbjct: 674  PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP-TTLKEPA----PTTPK-- 726

Query: 1103 VVNPQPQQWSKMSVKK-------APPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
               P P++ +  + K+        P PT PK       T     ++P   T     PT+P
Sbjct: 727  --KPAPKELAPTTTKEPTSTTCDKPAPTTPKG------TAPTTPKEPAPTTPKEPAPTTP 778

Query: 1156 KSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQK 1215
            K +    P  L +   T  +K   +  + ++      PT+T  D   P  P E      K
Sbjct: 779  KGT---APTTLKEPAPTTPKKPAPKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPK 832

Query: 1216 AGYGGSHISGYATLRRGPPP 1235
                 +      T    PPP
Sbjct: 833  EPAPTTPKKPAPTTPETPPP 852



 Score =  144 bits (363), Expect = 5e-34
 Identities = 165/663 (24%), Positives = 236/663 (35%), Gaps = 108/663 (16%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP--PPPPLPSQSAPSAGSA-APMF 664
            P    PK  TP T  +P+P    P P  P  P P  P  P P  P + AP+     AP  
Sbjct: 451  PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 510

Query: 665  VKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA 724
             K           + S    K P P   +S     +   P      P  P  P PT    
Sbjct: 511  TK-----------EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 559

Query: 725  MAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLP-PQAPPKPLV 783
             A   P   AP+ P+  AP  P          + AP TP  P P     P P  P +P  
Sbjct: 560  PAPTTPKEPAPTTPKKPAPTTP---------KEPAPTTPKEPAPTTTKKPAPTTPKEPAP 610

Query: 784  TIP---APTSTKTVAPVVTQA-APPTPTPPVP--PAKKQPAFPASYIP-----PSPPTPP 832
            T P   APT+ K + P   +  AP TP  P P  P +  P  P    P     P+P TP 
Sbjct: 611  TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPK 670

Query: 833  VPV------PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAME----SQP 882
                     P PT PK+ +     P +P  P P+  K+ A   P    P  ++    + P
Sbjct: 671  AAAPNTPKEPAPTTPKEPA-----PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 725

Query: 883  LKPVPANVAPQS----------PPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPP 930
             KP P  +AP +           PA        P++   P+P  P  P P       P  
Sbjct: 726  KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 785

Query: 931  PPSPVPAPPPPPPP-------TASPTPDKSGSPGKKTSKTSSP-GGKKPPPTPQRNSSIK 982
               P P  P  P P       T  PT   S  P   T K ++P   K+P PT  +     
Sbjct: 786  LKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK---P 842

Query: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
            + +  E P P    V +  +   P     SP + T P  +A P P  L  S    PGV  
Sbjct: 843  APTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST-PELSAEPTPKALENSPKE-PGVPT 900

Query: 1043 QGCVSAKAPVLSGRGKDSVVE---FPSPPSDSDFPPPPPET----------ELPLPPIEI 1089
                +A  P ++   KD   E     +P + +  P    ET          ++     ++
Sbjct: 901  TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 960

Query: 1090 PAVFSGNTSP------KVAVVNPQPQQWSK----MSVKKAPPPTRPKRNDSTRLTQAEIS 1139
             +  + +T+P      K   + P+     K      +   P  T   ++ +T       +
Sbjct: 961  TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRAT--NSKATT 1018

Query: 1140 EQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDD 1199
             +P   T  P+ PTS K   +        + R  + K+      ++S M    PT+ + +
Sbjct: 1019 PKPQKPTKAPKKPTSTKKPKT--------MPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 1070

Query: 1200 MAL 1202
              L
Sbjct: 1071 AML 1073



 Score =  104 bits (260), Expect = 5e-22
 Identities = 148/649 (22%), Positives = 219/649 (33%), Gaps = 90/649 (13%)

Query: 635  PPPPPPPPPPPPPPLPSQSAPSAGSAAPM---------------FVKYSTITRLQNASQH 679
            P  PP     PPP   SQ+  S    +P                  +  +++  Q +S  
Sbjct: 110  PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 169

Query: 680  SGALFKPPTPPVMQS-------QSVKPQILVPPNGV-VPPPPPPPPPPTPGSAMAQLKPA 731
            S +     T   ++S       + ++ ++ V  N        P P PP    A + L   
Sbjct: 170  SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 229

Query: 732  PCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQA--PPKPLVTIPAPT 789
                + P  S      K+     IT   P  P P       LPP +    +  +T+   T
Sbjct: 230  DFKVTTPDTSTTQHN-KVSTSPKITTAKPINPRP------SLPPNSDTSKETSLTVNKET 282

Query: 790  STKTVAPVVTQAAPPTP-TPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCA 848
            + +T     T     T        AK+  +   +      PT  V   P   PK ++   
Sbjct: 283  TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP--TPKAETTTK 340

Query: 849  KPP-PSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKP-VPANVAPQSPPAVKAKPKWQP 906
             P   +P  P P+  K+ AS  P  PTP  ++S P  P  PA    +S P    +P   P
Sbjct: 341  GPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEP--AP 398

Query: 907  SSIPVPSPDFP---------PPPPESSLVFPPPPPSPVPAPPPPPPPTA--SPTPDKSGS 955
            ++   P+P  P          P P ++   P  P  P P  P  P PT    P P     
Sbjct: 399  TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 458

Query: 956  PGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSK 1015
            P   T K  +P  K+P PT  +  +  +        PK P      +  TP   + + +K
Sbjct: 459  PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP------APTTPKEPAPTTTK 512

Query: 1016 ETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPP 1075
            E  P P  P +P                   +  AP        +  + P+P +  +  P
Sbjct: 513  E--PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 570

Query: 1076 PPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQ 1135
              P+   P  P E PA     T+PK     P P      +  K P PT PK         
Sbjct: 571  TTPKKPAPTTPKE-PA----PTTPK----EPAP------TTTKKPAPTTPK--------- 606

Query: 1136 AEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTA 1195
                 +P   T     PT+PK      P  LA    T ++ + T    L+   +  EPT 
Sbjct: 607  -----EPAPTTPKETAPTTPKKLTPTTPEKLAP--TTPEKPAPTTPEELAP-TTPEEPTP 658

Query: 1196 TMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQNT 1244
            T  +   P  P     +  K     +      T  + P P  PK    T
Sbjct: 659  TTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 707



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 68/320 (21%), Positives = 102/320 (31%), Gaps = 47/320 (14%)

Query: 608  PLSPQPKIVTPYT--------ASQPSPPLPP---PPPPPPPPPPPPPPPPPPLPSQSAPS 656
            P  P PK + P T        + +P+P  P    P  P  P P  P  P P  P    P+
Sbjct: 794  PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT 853

Query: 657  AGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPP 716
                +         T  ++  + +  L   PTP  +++   +P +   P    P    P 
Sbjct: 854  TSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGV---PTTKTPAATKPE 910

Query: 717  PPPTPGSAMAQ--LKPAP----CAPSLPQFSAPPPPLKIHQ--VQHITQVAPPTPPPPPP 768
               T      +  L+  P     AP + + +A               TQV   T     P
Sbjct: 911  MTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 970

Query: 769  IPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSP 828
                         + T+     T T+AP VT       T  +    ++ A P      S 
Sbjct: 971  F-----------KITTL----KTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSK 1015

Query: 829  PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPA 888
             T P P  P   PK+ +   KP   P    P             PTP  M S   +  P 
Sbjct: 1016 ATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT----------PTPRKMTSTMPELNPT 1065

Query: 889  NVAPQSPPAVKAKPKWQPSS 908
            +   ++      +P   P+S
Sbjct: 1066 SRIAEAMLQTTTRPNQTPNS 1085


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
            sapiens]
          Length = 483

 Score =  158 bits (400), Expect = 3e-38
 Identities = 148/498 (29%), Positives = 193/498 (38%), Gaps = 137/498 (27%)

Query: 624  PSPPLPPPPPPPPPPP---PPPPPPPPPLPSQSAPSAGSAAP-----MFVKYSTITRLQN 675
            P PP PPPP PPPPPP   PPPPPP  P  S    S   A P     +       TRL+ 
Sbjct: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61

Query: 676  ASQ-----------------------HSGALFKPPTP--------PVMQ----------- 693
             +Q                       ++     PPT         PV++           
Sbjct: 62   VTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGK 121

Query: 694  ------SQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747
                  S++  P++   PN  +  P  PP  P  G+       A  AP  P   APPP  
Sbjct: 122  TGQGPGSRAPSPRL---PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPP-- 176

Query: 748  KIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK-PLVTIPAPTSTKTVAPVVTQAAPPTP 806
                        P  PPPPPP+P PLP  +P K PLV+ P P  TK   PVV   APP P
Sbjct: 177  ------------PTPPPPPPPLPPPLPSSSPIKTPLVSPPGPL-TKGNLPVV---APPVP 220

Query: 807  TPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIA 866
              P PP            PP PPTPP P+PP ++   ++   +  P  L P+P  +  + 
Sbjct: 221  CAPPPPP-----------PPPPPTPP-PLPPASVLSDKAVKPQLAPLHLPPIPPPLPLL- 267

Query: 867  SQFPPPPTPPAMESQPLKPV-----PANVAPQSPPAVKAKPKWQPSSIPVP----SPDFP 917
                PP   P ++++P  P      P    P  PP     P+    + P+P    S + P
Sbjct: 268  ----PPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETP 323

Query: 918  PP-PPES-SLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK-KPPPT 974
            PP PP+S S   PP        P PP PP + P   K     K+  +  + GGK  PPP 
Sbjct: 324  PPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQK-----KRHGRPGAGGGKLNPPPA 378

Query: 975  PQRNS-----SIKSSSGAEHPEPKRPS----------VDSLVSKFT-------PPAESGS 1012
            P   S     S KS         ++P           +D   SKFT       PP +   
Sbjct: 379  PPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYK 438

Query: 1013 PSKETLP---PPAAPPKP 1027
            P ++  P   P +  P P
Sbjct: 439  PCQKIYPSKIPRSRTPGP 456



 Score =  100 bits (250), Expect = 7e-21
 Identities = 134/494 (27%), Positives = 176/494 (35%), Gaps = 103/494 (20%)

Query: 709  VPPPPPPPPP-PTPGSAMAQLKPAPCAPSLPQFSAPPPPLK-------------IHQVQH 754
            +P PPPPPPP P P   +    P P  PS P  S     L+             I Q   
Sbjct: 1    MPVPPPPPPPLPPPPPPLG--APPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58

Query: 755  ITQVAPPTPPPPPPIP-----------------APLPPQAPPKPLVTIPA--PTSTKTVA 795
            + +V        P I                  A  PP          P   P   + VA
Sbjct: 59   LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVA 118

Query: 796  PVVTQAAP----PTPT--------PPVPPAK------------KQPAFPASYIP-PSPPT 830
               T   P    P+P         P +PPA              + A P   +P P PPT
Sbjct: 119  GGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPT 178

Query: 831  PPVPVP--PPTLPKQQSFCAK--PPPSPLSP--VPSVVKQIASQFPPPPTPPAMESQPLK 884
            PP P P  PP LP           PP PL+   +P V   +    PPPP PP        
Sbjct: 179  PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP-------P 231

Query: 885  PVPANVAPQSPPAVKA-KPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPV------PA 937
            P P  + P S  + KA KP+  P  +P   P  P  PP         P SP       PA
Sbjct: 232  PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPA 291

Query: 938  PPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKS---SSGAEH-PEPK 993
            PPPP PP AS +P ++  P       +S   + PPP P ++ S ++    +GA+  P P 
Sbjct: 292  PPPPLPPYASCSP-RASLPAPPLPGVNS-SSETPPPLPPKSPSFQAPPQKAGAQALPAPP 349

Query: 994  RPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLP-----------GVLQ 1042
             P       +       G+   +  PPPA P +     LS  +             G L+
Sbjct: 350  APPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLR 409

Query: 1043 QGCVSAKAPVLSGRGKDSVVEFPSP----PSDSDFPPPPPETELPLPPIEIPAVFSGNTS 1098
             G +       S     SV +FP P    P    +P   P +  P P ++  AV  G +S
Sbjct: 410  NGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPWLQAEAV--GQSS 467

Query: 1099 PKVAVVNPQPQQWS 1112
              +   N Q  Q S
Sbjct: 468  DDIKGRNSQVTQAS 481



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 99/380 (26%), Positives = 134/380 (35%), Gaps = 87/380 (22%)

Query: 553 QSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQ 612
           ++  G     P+  + +++I   +   A  R     E+  A   +  RP     PP +P 
Sbjct: 121 KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPP 180

Query: 613 PK---IVTPYTASQP------SPP-----------LPPPPPPPPPPPPPPPPPPPPLPSQ 652
           P    +  P  +S P      SPP            PP P  PPPPPPPPPP PPPLP  
Sbjct: 181 PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPA 240

Query: 653 SAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPP 712
           S                                     V+  ++VKPQ+   P  + P P
Sbjct: 241 S-------------------------------------VLSDKAVKPQL--APLHLPPIP 261

Query: 713 PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAP 772
           PP P  P  G    + +PA  A    +  APPPPL  +        +P    P PP+P  
Sbjct: 262 PPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPY-----ASCSPRASLPAPPLPGV 316

Query: 773 LPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK---------QPAFPASY 823
                 P PL     P S    AP     A   P PP PP  +         +P      
Sbjct: 317 NSSSETPPPL----PPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372

Query: 824 IPPSPPTPPVPVPPPTL--PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPT------- 874
           + P PP PP   P   L    QQ+    P   P   + +    I   F    T       
Sbjct: 373 LNP-PPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDF 431

Query: 875 PPAMESQPLKPVPANVAPQS 894
           PP  E +P + +  +  P+S
Sbjct: 432 PPPDEYKPCQKIYPSKIPRS 451



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 109/427 (25%), Positives = 156/427 (36%), Gaps = 46/427 (10%)

Query: 826  PSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM----ESQ 881
            P PP PP+P PPP L       A PPP P +P  S       +  P      +    +  
Sbjct: 4    PPPPPPPLPPPPPPLG------APPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57

Query: 882  PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPP 941
             L+ V   +  +S P +++            +      PP    +F    P   PA    
Sbjct: 58   RLRKV-TQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRD 116

Query: 942  PPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLV 1001
                 +     S +P  +    +  G   PP +P R  +   + GA    P RP+V +  
Sbjct: 117  VAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASP-RLGNTSEAHGAARTAPPRPNVPA-- 173

Query: 1002 SKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSV 1061
                PP  +  P    LPPP     P K  L  V+ PG L +G +   AP         V
Sbjct: 174  ----PPPPTPPPPPPPLPPPLPSSSPIKTPL--VSPPGPLTKGNLPVVAP--------PV 219

Query: 1062 VEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPP 1121
               P PP     PPPPP T  PLPP  +  +      P++A ++  P       +   PP
Sbjct: 220  PCAPPPP-----PPPPPPTPPPLPPASV--LSDKAVKPQLAPLHLPP---IPPPLPLLPP 269

Query: 1122 PTRPKRNDSTRLTQAEISEQPTMATVVPQVPT-SPKSSLSVQPGFLADLNRTLQRKSITR 1180
               P           +  E P     +P   + SP++SL   P  L  +N + +      
Sbjct: 270  CGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPP--LPGVNSSSETPPPLP 327

Query: 1181 HGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKR 1240
              S S +    +  A    +  PP PP      QK  +G     G    +  PPPAPP R
Sbjct: 328  PKSPSFQAPPQKAGAQA--LPAPPAPPGSQPFLQKKRHGRPGAGGG---KLNPPPAPPAR 382

Query: 1241 DQNTKLS 1247
               T+LS
Sbjct: 383  SPTTELS 389


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  155 bits (392), Expect = 2e-37
 Identities = 122/429 (28%), Positives = 162/429 (37%), Gaps = 65/429 (15%)

Query: 611  PQPKIVTPYTASQPSPPLPPPPPPPPPP---PPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P  K +T      PSPP   P PPP      PP   P PP   + + P   + +P     
Sbjct: 1391 PMDKCITT-----PSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPI--- 1442

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPP------PPPPPPPTP 721
            +T T     +  S  +    TPP   + S       PP     PP      PPP   P+P
Sbjct: 1443 TTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSP 1502

Query: 722  GSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKP 781
             +    + P     +LP  + P PP         T   PPT  P PP   P+ P      
Sbjct: 1503 PTT-TPITPPASTTTLPPTTTPSPPTT------TTTTPPPTTTPSPPTTTPITP------ 1549

Query: 782  LVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPP-TL 840
                  PTST T+ P  T + PPT T   PP       P +   PSPPT     PPP T 
Sbjct: 1550 ------PTSTTTLPPTTTPSPPPTTTTTPPPTTTPS--PPTTTTPSPPTITTTTPPPTTT 1601

Query: 841  PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKA 900
            P   +     PP   +P             PP T P         +P    P  PP    
Sbjct: 1602 PSPPTTTTTTPPPTTTP------------SPPTTTPITPPTSTTTLPPTTTPSPPPTTTT 1649

Query: 901  KPKWQPSSIPVPSPDFPPPPPESSLVFPPP---PPSPVPAPPPPPPPTASPTPDKSGSPG 957
             P   P++ P P     P PP ++   PPP   P SP+   P PP  T + TP  + +P 
Sbjct: 1650 TP--PPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMT-TPSPTTTPS 1706

Query: 958  KKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKET 1017
               + T++P     P  P   +++ + S    P P   ++ +L     PP  + SP   T
Sbjct: 1707 SPITTTTTPSSTTTPSPPP--TTMTTPSPTTTPSPPTTTMTTL-----PPTTTSSPLTTT 1759

Query: 1018 -LPPPAAPP 1025
             LPP   PP
Sbjct: 1760 PLPPSITPP 1768



 Score =  143 bits (361), Expect = 9e-34
 Identities = 117/433 (27%), Positives = 152/433 (35%), Gaps = 70/433 (16%)

Query: 687  PTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPP 746
            P+PP   + ++ P     P       PPP   P+P        P     + P  + P PP
Sbjct: 1406 PSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSP--------PITTTTTPPPTTTPSPP 1457

Query: 747  LKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTP 806
            +        T   PPT  P PP   P PP   P P      PT+T T  P  T  +PPT 
Sbjct: 1458 IST------TTTPPPTTTPSPPTTTPSPPTTTPSP------PTTTTTTPPPTTTPSPPTT 1505

Query: 807  TPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIA 866
            TP  PPA      P +   PSPPT     PPPT          P P   +P+        
Sbjct: 1506 TPITPPASTTTLPPTT--TPSPPTTTTTTPPPT--------TTPSPPTTTPI-------- 1547

Query: 867  SQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLV 926
                   TPP   +     +P    P  PP     P   P++ P P     P PP  +  
Sbjct: 1548 -------TPPTSTTT----LPPTTTPSPPPTTTTTPP--PTTTPSPPTTTTPSPPTITTT 1594

Query: 927  FPPPPPSPVPAPPPP------PPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSS 980
             PPP       P PP      PPPT +P+P  +      TS T+ P    P P P   ++
Sbjct: 1595 TPPP----TTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTT 1650

Query: 981  IKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETL--PPPAAPPKPGKLNLSGVNLP 1038
               ++    P    PS     +   PP  + S    T   PP      P         + 
Sbjct: 1651 PPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPIT 1710

Query: 1039 GVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPP-----PETELPLPPIEIPAVF 1093
                    +  +P  +     S    PSPP+ +    PP     P T  PLPP   P  F
Sbjct: 1711 TTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTF 1770

Query: 1094 S--GNTSPKVAVV 1104
            S    T+P    V
Sbjct: 1771 SPFSTTTPTTPCV 1783



 Score =  133 bits (335), Expect = 9e-31
 Identities = 114/419 (27%), Positives = 147/419 (35%), Gaps = 54/419 (12%)

Query: 755  ITQVAPPT--PPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP 812
            IT  +PPT  P PPP     LPP   P P      PT+T T  P  T  +PP  T   PP
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTTTPSP------PTTTTTTPPPTTTPSPPITTTTTPP 1449

Query: 813  AKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPP 872
                P+ P S     PPT   P PP T P   +    PP +  +  P           PP
Sbjct: 1450 PTTTPSPPISTTTTPPPTT-TPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTP-----SPP 1503

Query: 873  PTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPP 932
             T P         +P    P  P      P   P++ P P    P  PP S+   PP   
Sbjct: 1504 TTTPITPPASTTTLPPTTTPSPPTTTTTTPP--PTTTPSPPTTTPITPPTSTTTLPP--- 1558

Query: 933  SPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSP---GGKKPPPT-----PQRNSSIKSS 984
                   P PPPT + TP  + +P   T+ T SP       PPPT     P   ++    
Sbjct: 1559 ----TTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPP 1614

Query: 985  SGAEHPEPKRPSVDSLVSKFTPPAESGS--PSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
            +    P    P      +   PP  + S  P+  T PPP   P P         +     
Sbjct: 1615 TTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPI----- 1669

Query: 1043 QGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVA 1102
                +   P  +      +   PSPP+ +   P P  T  P  PI      S  T+P   
Sbjct: 1670 ---TTTTTPPPTTTPSSPITTTPSPPTTTMTTPSP--TTTPSSPITTTTTPSSTTTP--- 1721

Query: 1103 VVNPQPQQWSKMSVKKAPPP------TRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
              +P P   +  S    P P      T P    S+ LT   +    T  T  P   T+P
Sbjct: 1722 --SPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTP 1778



 Score =  115 bits (287), Expect = 3e-25
 Identities = 92/324 (28%), Positives = 120/324 (37%), Gaps = 39/324 (12%)

Query: 603  TSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAP 662
            T+  P  +P P   TP T    +  LPP   P PP      PPP      + PS  +  P
Sbjct: 1492 TTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPT-----TTPSPPTTTP 1546

Query: 663  MFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPG 722
            +    ST T L   +  S       TPP   + S        P  +    PPP   P+P 
Sbjct: 1547 ITPPTSTTT-LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPP 1605

Query: 723  SAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPL 782
            +      P    PS P  +   PP         T + P T P PPP     PP     P 
Sbjct: 1606 TTTTTTPPPTTTPSPPTTTPITPPTS------TTTLPPTTTPSPPPTTTTTPP-----PT 1654

Query: 783  VTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYI-PPSP-PTPPVPVPPPTL 840
             T   PT+T    P+ T   PP  T P  P    P+ P + +  PSP  TP  P+   T 
Sbjct: 1655 TTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTT 1714

Query: 841  PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPT------PPAMESQPLKPVPANVAPQS 894
            P   +  + PP +  +P P+         P PPT      PP   S PL   P       
Sbjct: 1715 PSSTTTPSPPPTTMTTPSPTTT-------PSPPTTTMTTLPPTTTSSPLTTTPL------ 1761

Query: 895  PPAVKAKPKWQPSSIPVPSPDFPP 918
            PP++   P + P S   P+    P
Sbjct: 1762 PPSI-TPPTFSPFSTTTPTTPCVP 1784



 Score =  113 bits (283), Expect = 1e-24
 Identities = 102/411 (24%), Positives = 139/411 (33%), Gaps = 68/411 (16%)

Query: 798  VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL-PKQQSFCAKPPPSPLS 856
            +T  +PPT TP  PP       P +   PSPPT     PPPT  P         PP   +
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTT--TPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTT 1453

Query: 857  PVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDF 916
            P P +     +  PPP T P+  +    P P    P  P      P   P++ P P    
Sbjct: 1454 PSPPIS---TTTTPPPTTTPSPPTTT--PSPPTTTPSPPTTTTTTPP--PTTTPSPPTTT 1506

Query: 917  PPPPPESSLVFPPPP-PSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP 975
            P  PP S+   PP   PSP       PPPT +P+P  +      TS T+ P    P P P
Sbjct: 1507 PITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPP 1566

Query: 976  QRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGV 1035
               ++   ++    P    PS  ++ +   PP  + SP   T   P  PP          
Sbjct: 1567 TTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTP--PP---------- 1614

Query: 1036 NLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSG 1095
                                         PSPP+ +   PP   T LP      P   + 
Sbjct: 1615 --------------------------TTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTT 1648

Query: 1096 NTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
             T P     +P             P  T P    +T  T    +   +  T  P  PT+ 
Sbjct: 1649 TTPPPTTTPSP-------------PTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTT 1695

Query: 1156 KSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPP 1206
             ++ S      + +  T    S T      + M+   PT T      P PP
Sbjct: 1696 MTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTT------PSPP 1740



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 122/572 (21%), Positives = 179/572 (31%), Gaps = 54/572 (9%)

Query: 612  QPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQS-APSAGSAAPMFVKYSTI 670
            QP  +T  T   P+PP   P        P P P     P+ +   +  +  P      T 
Sbjct: 1881 QPTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 1940

Query: 671  TRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPP---PPPPPTPGSAMAQ 727
            T        +  +   PTP   Q+ +  P  +     V P P P     P  TP +    
Sbjct: 1941 TPTTTPITTTTTVTPTPTPTGTQTPTTTP--ITTTTTVTPTPTPTGTQTPTTTPITTTTT 1998

Query: 728  LKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPPQAPPKPL 782
            + P P  P+  Q     P         IT     TP P P     P   P+       P 
Sbjct: 1999 VTPTP-TPTGTQTPTTTP---------ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2048

Query: 783  VTIPAPTSTKTVAPV-VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLP 841
             T P  T T T  P+  T    PTPTP             +      PTP     P T P
Sbjct: 2049 PT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2107

Query: 842  KQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANVAPQSPPA 897
               +    P P+P          I   +   P PTP   ++    P+     V P   P 
Sbjct: 2108 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2167

Query: 898  VKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPPPP----- 944
                P   P     +  P P+P     P   P ++     P P+P     P   P     
Sbjct: 2168 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2227

Query: 945  TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKF 1004
            T +PTP  +G+    T+  ++     P PTP    +           P    + +  +  
Sbjct: 2228 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPITTTTTVT 2276

Query: 1005 TPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEF 1064
              P  +G+ +  T P             +G   P        +   P  +  G  +    
Sbjct: 2277 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2336

Query: 1065 PSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPP 1122
            P   + +  P P P  T+ P   PI      +   +P            +  +V   P P
Sbjct: 2337 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2396

Query: 1123 TRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            T  +   +T +T    +  PT      Q PT+
Sbjct: 2397 TGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 2427



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 138/670 (20%), Positives = 204/670 (30%), Gaps = 83/670 (12%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 3615 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 3672

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 3673 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 3729

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 3730 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3789

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 3790 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3848

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 3849 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3908

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 3909 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3968

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSS------IKSSSGAEHPE 991
             P     T +PTP  +G+    T+  ++     P PTP    +        +++    P 
Sbjct: 3969 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 4028

Query: 992  P---KRPSVDSLVSKFT---PPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGC 1045
            P   + P+   + +  T    P  +G+ +  T P             +G   P       
Sbjct: 4029 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4088

Query: 1046 VSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPE----------------TELPLP---- 1085
             +   P  +  G  +    P   + +  P P P                 T  P P    
Sbjct: 4089 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4148

Query: 1086 -PIEIPAVFSGNTSPKVAVVNPQPQQWSKM----SVKKAPPPTRPKRNDSTRLTQAEISE 1140
             P   P   +   +P       Q    + +    +V   P PT  +    T  + A I+E
Sbjct: 4149 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAE 4208

Query: 1141 ----QPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTAT 1196
                 P   +  PQ   S  S L+     L+ L   ++  S     + ++      PT T
Sbjct: 4209 LTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTA------PTTT 4262

Query: 1197 MDDMALPPPP 1206
                 L PPP
Sbjct: 4263 SGGHTLSPPP 4272



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 74/261 (28%), Positives = 95/261 (36%), Gaps = 62/261 (23%)

Query: 601  PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPP----PPPPPLPSQSAPS 656
            P T+  PP +  P   +P T + PSPP      PPP   P PP      PPP  + S P+
Sbjct: 1566 PTTTTTPPPTTTP---SPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPT 1622

Query: 657  AGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPP 716
                                         P TPP   +              +PP   P 
Sbjct: 1623 T---------------------------TPITPPTSTT-------------TLPPTTTPS 1642

Query: 717  PPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ 776
            PPPT  +      P    PS P  + P PP+        T   PPT  P  PI       
Sbjct: 1643 PPPTTTTT----PPPTTTPSPPTTTTPSPPIT------TTTTPPPTTTPSSPITT---TP 1689

Query: 777  APPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP 836
            +PP   +T P+PT+T + +P+ T   P + T P PP       P+    PSPPT  +   
Sbjct: 1690 SPPTTTMTTPSPTTTPS-SPITTTTTPSSTTTPSPPPTTMTT-PSPTTTPSPPTTTMTTL 1747

Query: 837  PPTLPKQQSFCAKPPPSPLSP 857
            PPT           PPS   P
Sbjct: 1748 PPTTTSSPLTTTPLPPSITPP 1768



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 120/577 (20%), Positives = 177/577 (30%), Gaps = 50/577 (8%)

Query: 610  SPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYST 669
            +P P   TP T +    P P P     P   P        P+ +    G+  P     +T
Sbjct: 1892 NPTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTPTTTPITT 1949

Query: 670  ITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPTPG 722
             T +      +G    P T P+  + +V P     P G   P   P        P PTP 
Sbjct: 1950 TTTVTPTPTPTGTQ-TPTTTPITTTTTVTP--TPTPTGTQTPTTTPITTTTTVTPTPTPT 2006

Query: 723  SAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPPQA 777
                         +    +  P   +      IT     TP P P     P   P+    
Sbjct: 2007 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2066

Query: 778  PPKPLVTIPAPTSTKTVAPV-VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP 836
               P  T P  T T T  P+  T    PTPTP             +      PTP     
Sbjct: 2067 TVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2125

Query: 837  PPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANVAP 892
            P T P   +    P P+P          I   +   P PTP   ++    P+     V P
Sbjct: 2126 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 2185

Query: 893  QSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPPPP 944
               P     P   P     +  P P+P     P   P ++     P P+P     P   P
Sbjct: 2186 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2245

Query: 945  -----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDS 999
                 T +PTP  +G+    T+  ++     P PTP    +           P    + +
Sbjct: 2246 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPITT 2294

Query: 1000 LVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKD 1059
              +    P  +G+ +  T P             +G   P        +   P  +  G  
Sbjct: 2295 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2354

Query: 1060 SVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVK 1117
            +    P   + +  P P P  T+ P   PI      +   +P            +  +V 
Sbjct: 2355 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2414

Query: 1118 KAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
              P PT  +   +T +T    +  PT      Q PT+
Sbjct: 2415 PTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 2450



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 127/541 (23%), Positives = 173/541 (31%), Gaps = 71/541 (13%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 3891 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 3948

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 3949 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 4005

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 4006 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4065

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 4066 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4124

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ--FPPPPTPPAMESQPLKPVPAN--V 890
              P T P   +    P P+P          I +     P PTP   ++    P+     V
Sbjct: 4125 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 4184

Query: 891  APQ-SPPAVKAKPKWQPSSIPVPSPDFPPPPPESS-----------------LVFPPPPP 932
             P  +P   +  P    S+ P+       PPPESS                 L+   PP 
Sbjct: 4185 TPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPA 4244

Query: 933  SPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEP 992
              + +  PP  PTA  T     +     S T+SP     P TP R ++  SSS    P P
Sbjct: 4245 IEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSP-----PGTPTRGTTTGSSSA---PTP 4296

Query: 993  KRPSVDSLVSKFTP-PAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAP 1051
                  +  S +TP P    +PS   +      P P     S V +  VL     +    
Sbjct: 4297 STVQTTT-TSAWTPTPTPLSTPS--IIRTTGLRPYP-----SSVLICCVLNDTYYAPGEE 4348

Query: 1052 VLSGRGKDS----------VVEFPS---PPSDSDFPPPPPETELPLPPIEIPAVFSGNTS 1098
            V +G   D+           +EF +   P + S  P P   T  P  P   P+  +  T 
Sbjct: 4349 VYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPSSTPSKPTPGTK 4408

Query: 1099 P 1099
            P
Sbjct: 4409 P 4409



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 1913 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTPTTTPI 1970

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 1971 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTP--TPTPTGTQTPTTTPITTTTTVTPTPT 2027

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2028 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2087

Query: 776  QAPPKPLVTIPAPTSTKTVAPV-VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+  T    PTPTP             +      PTP   
Sbjct: 2088 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2146

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 2147 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2206

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 2207 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2266

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 2267 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 2315

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 2316 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2375

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 2376 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2435

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 2436 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 2473



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 1959 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2016

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2017 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 2073

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2074 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2133

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 2134 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2192

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 2193 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2252

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 2253 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2312

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 2313 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 2361

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 2362 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2421

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 2422 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2481

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 2482 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 2519



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 2097 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2154

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2155 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 2211

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2212 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2271

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 2272 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2330

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 2331 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2390

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 2391 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2450

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 2451 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 2499

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 2500 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2559

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 2560 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2619

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 2620 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 2657



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 2235 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2292

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2293 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 2349

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2350 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2409

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 2410 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2468

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 2469 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2528

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 2529 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2588

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 2589 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 2637

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 2638 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2697

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 2698 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2757

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 2758 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 2795



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 2373 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2430

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2431 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 2487

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2488 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2547

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 2548 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2606

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 2607 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2666

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 2667 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2726

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 2727 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 2775

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 2776 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2835

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 2836 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2895

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 2896 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 2933



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 2511 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2568

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2569 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 2625

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2626 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2685

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 2686 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2744

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 2745 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2804

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 2805 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2864

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 2865 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 2913

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 2914 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2973

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 2974 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3033

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 3034 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 3071



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 2649 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2706

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2707 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 2763

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2764 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2823

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 2824 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2882

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 2883 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2942

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 2943 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3002

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 3003 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 3051

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 3052 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3111

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 3112 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3171

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 3172 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 3209



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 2787 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2844

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2845 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 2901

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 2902 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2961

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 2962 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3020

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 3021 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3080

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 3081 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3140

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 3141 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 3189

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 3190 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3249

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 3250 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3309

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 3310 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 3347



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 2925 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 2982

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 2983 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 3039

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 3040 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3099

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 3100 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3158

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 3159 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3218

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 3219 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3278

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 3279 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 3327

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 3328 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3387

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 3388 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3447

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 3448 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 3485



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 3063 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 3120

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 3121 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 3177

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 3178 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3237

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 3238 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3296

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 3297 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3356

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 3357 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3416

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 3417 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 3465

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 3466 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3525

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 3526 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3585

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 3586 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 3623



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 3201 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 3258

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 3259 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 3315

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 3316 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3375

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 3376 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3434

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 3435 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3494

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 3495 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3554

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 3555 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 3603

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 3604 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3663

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 3664 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3723

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 3724 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 3761



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 3339 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 3396

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 3397 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 3453

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 3454 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3513

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 3514 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3572

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 3573 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3632

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 3633 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3692

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 3693 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 3741

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 3742 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3801

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 3802 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3861

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 3862 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 3899



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 120/579 (20%), Positives = 176/579 (30%), Gaps = 50/579 (8%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 3477 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 3534

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 3535 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 3591

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 3592 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3651

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 3652 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3710

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANV 890
              P T P   +    P P+P          I   +   P PTP   ++    P+     V
Sbjct: 3711 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3770

Query: 891  APQSPPAVKAKPKWQP-----SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P     +  P P+P     P   P ++     P P+P     P  
Sbjct: 3771 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3830

Query: 943  PP-----TASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSV 997
             P     T +PTP  +G+    T+  ++     P PTP    +           P    +
Sbjct: 3831 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPI 3879

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
             +  +    P  +G+ +  T P             +G   P        +   P  +  G
Sbjct: 3880 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3939

Query: 1058 KDSVVEFPSPPSDSDFPPPPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
              +    P   + +  P P P  T+ P   PI      +   +P            +  +
Sbjct: 3940 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3999

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154
            V   P PT  +   +T +T    +  PT      Q PT+
Sbjct: 4000 VTPTPTPTGTQTPTTTPIT-TTTTVTPTPTPTGTQTPTT 4037



 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 128/593 (21%), Positives = 181/593 (30%), Gaps = 72/593 (12%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 3845 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 3902

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP-------PPPPT 720
            +T T +      +G    P T P+  + +V P     P G   P   P        P PT
Sbjct: 3903 TTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT--PTPTGTQTPTTTPITTTTTVTPTPT 3959

Query: 721  PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP-----PIPAPLPP 775
            P              +    +  P   +      IT     TP P P     P   P+  
Sbjct: 3960 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4019

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAA-PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVP 834
                 P  T P  T T T  P+ T     PTPTP             +      PTP   
Sbjct: 4020 TTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4078

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ--FPPPPTPPAMESQPLKPVPAN--V 890
              P T P   +    P P+P          I +     P PTP   ++    P+     V
Sbjct: 4079 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 4138

Query: 891  APQSPPAVKAKPKWQPSSI-----PVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPP 942
             P   P     P   P +      P P+P     P   P ++     P P+P      PP
Sbjct: 4139 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPP 4198

Query: 943  PPT-ASP-------TPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKR 994
              T  +P        P    S  + +  TSSP  +          +I+ +S A    P  
Sbjct: 4199 THTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTA 4258

Query: 995  PSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLS 1054
            P+  S     +PP  +      T  PP  P +      S    P  +Q    SA  P  +
Sbjct: 4259 PTTTSGGHTLSPPPST------TTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPT 4312

Query: 1055 GRGKDSVVEF----PSPPS-------DSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAV 1103
                 S++      P P S       +  +  P  E            V++G        
Sbjct: 4313 PLSTPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEE------------VYNGTYGDTCYF 4360

Query: 1104 VNPQ---PQQWSKMSVKKAPPPT-RPKRNDSTRLTQAEISEQPTMATVVPQVP 1152
            VN       ++   S    P PT  P ++  T    +    +PT  T  P+ P
Sbjct: 4361 VNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPSSTPSKPTPGTKPPECP 4413



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 129/621 (20%), Positives = 187/621 (30%), Gaps = 89/621 (14%)

Query: 601  PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPP---PPPPPLPSQSAPSA 657
            P T+  PP +  P   +P T + PSPP+     PPP   P  P    P PP  + + PS 
Sbjct: 1645 PTTTTTPPPTTTP---SPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSP 1701

Query: 658  GSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGV-----VPPP 712
             +     +  +T                 P+P    S        +PP          P 
Sbjct: 1702 TTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPL 1761

Query: 713  PPPPPPPTPGSAMAQLKPAPCAP----------SLPQFSAPPPPLKIHQVQHITQVAPPT 762
            PP   PPT           PC P            P F  P    ++     I  V  P 
Sbjct: 1762 PPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGGDTEL-----IGDVCGPG 1816

Query: 763  PPPPPPIPAPLPPQAP----------------------PKPLVTIPAPTSTKTVAPV--- 797
                    A + P  P                       KP   IP          V   
Sbjct: 1817 WAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCC 1876

Query: 798  --VTQAAPPTPTP---PVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPP 852
              VTQ    T T    P PP    P    + + P+P TP     P T P   +    P P
Sbjct: 1877 ECVTQPTTMTTTTTENPTPPTTT-PITTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTP 1934

Query: 853  SPLSPVPSVVKQI--ASQFPPPPTPPAMESQPLKPV--PANVAPQSPPAVKAKPKWQP-- 906
            +P          I   +   P PTP   ++    P+     V P   P     P   P  
Sbjct: 1935 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 1994

Query: 907  ---SSIPVPSP---DFPPPPPESSLVFPPPPPSPVPAPPPPPPP-----TASPTPDKSGS 955
               +  P P+P     P   P ++     P P+P     P   P     T +PTP  +G+
Sbjct: 1995 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2054

Query: 956  PGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSK 1015
                T+  ++     P PTP    +           P    + +  +    P  +G+ + 
Sbjct: 2055 QTPTTTPITTTTTVTPTPTPTGTQT-----------PTTTPITTTTTVTPTPTPTGTQTP 2103

Query: 1016 ETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPP 1075
             T P             +G   P        +   P  +  G  +    P   + +  P 
Sbjct: 2104 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2163

Query: 1076 PPPE-TELP-LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRL 1133
            P P  T+ P   PI      +   +P            +  +V   P PT  +   +T +
Sbjct: 2164 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2223

Query: 1134 TQAEISEQPTMATVVPQVPTS 1154
            T    +  PT      Q PT+
Sbjct: 2224 T-TTTTVTPTPTPTGTQTPTT 2243



 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 89/376 (23%), Positives = 125/376 (33%), Gaps = 52/376 (13%)

Query: 885  PVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPP--PSPVPAPPPPP 942
            P+   +   SPP     P   P+S     P   P PP ++   PPP   PSP       P
Sbjct: 1391 PMDKCITTPSPPTTTPSPP--PTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTP 1448

Query: 943  PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVS 1002
            PPT +P+P  S +     + T SP    P P P    S  +++    P    PS  +  +
Sbjct: 1449 PPTTTPSPPISTTTTPPPTTTPSPPTTTPSP-PTTTPSPPTTTTTTPPPTTTPSPPT-TT 1506

Query: 1003 KFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVV 1062
              TPPA     S  TLPP   P  P                   +   P  +     +  
Sbjct: 1507 PITPPA-----STTTLPPTTTPSPPTT----------------TTTTPPPTTTPSPPTTT 1545

Query: 1063 EFPSPPSDSDFPP-----PPPETELPLPPIEIPAVFSGNT--SPKVAVVNPQPQQWSK-- 1113
                P S +  PP     PPP T    PP   P+  +  T   P +    P P       
Sbjct: 1546 PITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPP 1605

Query: 1114 -MSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVP--QVPTSPKSSLSVQPGFLADLN 1170
              +    PP T P    +T +T       PT  T +P    P+ P ++ +  P       
Sbjct: 1606 TTTTTTPPPTTTPSPPTTTPIT------PPTSTTTLPPTTTPSPPPTTTTTPPP-----T 1654

Query: 1171 RTLQRKSITRHGSLSSRMSRAEPTATMDD--MALPPPPPELLSDQQKAGYGGSHISGYAT 1228
             T    + T      +  +   PT T        P PP   ++         S I+   T
Sbjct: 1655 TTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTT 1714

Query: 1229 LRRGPPPAPPKRDQNT 1244
                  P+PP     T
Sbjct: 1715 PSSTTTPSPPPTTMTT 1730



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 84/375 (22%), Positives = 116/375 (30%), Gaps = 86/375 (22%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKY 667
            P   Q    TP T +    P P P     P   P        P+ +    G+  P     
Sbjct: 4075 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTPTTTPI 4132

Query: 668  STITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP---PPPPTPGSA 724
            +T T +             PTP   Q+ +  P  +     V P P P     P  TP + 
Sbjct: 4133 TTTTTVTPT----------PTPTGTQTPTTTP--ITTTTTVTPTPTPTGTQTPTTTPITT 4180

Query: 725  MAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVT 784
               + P P  P+  Q + PP       +  +T     T  PPP    P   ++   PL  
Sbjct: 4181 TTTVTPTP-TPTGTQ-TGPPTHTSTAPIAELT-----TSNPPPESSTPQTSRSTSSPLTE 4233

Query: 785  IPAPTSTKTVAPVVTQAAPP-TPTPPVPPAKKQPAFPASYIPPSPPTPPV---------P 834
                 ST   A  +T  APP TPT P   +      P      SPP  P           
Sbjct: 4234 STTLLSTLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSA 4293

Query: 835  VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPP---------------------- 872
              P T+    +    P P+PLS  PS+++    +  P                       
Sbjct: 4294 PTPSTVQTTTTSAWTPTPTPLS-TPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYNG 4352

Query: 873  ------------------------PTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSS 908
                                    P+ P+    P K  P    P  P +  +KP   P +
Sbjct: 4353 TYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPT---PSKPSSTPSKPT--PGT 4407

Query: 909  IPVPSPDFPPPPPES 923
             P   PDF PP  E+
Sbjct: 4408 KPPECPDFDPPRQEN 4422



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 44/203 (21%), Positives = 68/203 (33%), Gaps = 18/203 (8%)

Query: 588  EESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPP---PPPPPPPP 644
            E S+     S + P T     LS  P  +   + + PS P  P          PPP    
Sbjct: 4217 ESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTT 4276

Query: 645  PPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPP--TPPVMQSQSVKPQ-- 700
             PP  P++   +  S+AP      T + +Q  +  +      P  TP ++++  ++P   
Sbjct: 4277 SPPGTPTRGTTTGSSSAP------TPSTVQTTTTSAWTPTPTPLSTPSIIRTTGLRPYPS 4330

Query: 701  ---ILVPPNGVVPPPPPPPPPPTPGSAMAQLK-PAPCAPSLPQFSAPPPPLKIHQVQHIT 756
               I    N     P       T G     +     C      +S P  P         T
Sbjct: 4331 SVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKST 4390

Query: 757  QV-APPTPPPPPPIPAPLPPQAP 778
               + P+  P  P P   PP+ P
Sbjct: 4391 PTPSKPSSTPSKPTPGTKPPECP 4413


>gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score =  152 bits (384), Expect = 2e-36
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 273 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 332
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 112 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 171

Query: 333 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 392
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 172 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 229

Query: 393 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 452
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 230 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 288

Query: 453 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 512
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 289 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 348

Query: 513 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 564
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 349 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 396


>gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score =  152 bits (384), Expect = 2e-36
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 273 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 332
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 112 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 171

Query: 333 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 392
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 172 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 229

Query: 393 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 452
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 230 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 288

Query: 453 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 512
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 289 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 348

Query: 513 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 564
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 349 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 396


>gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo
           sapiens]
          Length = 594

 Score =  152 bits (384), Expect = 2e-36
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 273 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 332
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229

Query: 333 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 392
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287

Query: 393 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 452
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346

Query: 453 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 512
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406

Query: 513 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 564
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score =  150 bits (380), Expect = 6e-36
 Identities = 188/668 (28%), Positives = 244/668 (36%), Gaps = 99/668 (14%)

Query: 536  SGSSSSSIPESQSNHSNQSDSG-VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKAR 594
            SG    + P   ++    S  G  S T   G +  + +  S   E   RG   E   ++ 
Sbjct: 97   SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA-EETVARGKATEAPKRSA 155

Query: 595  MESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP---------- 644
            + +  R  TS   P +P P +     A+     LP P P   P PP   P          
Sbjct: 156  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 215

Query: 645  --PPPPLPSQSAPSAGSAAPMFVKYS---TITRLQNASQHSGALFKPPTPPVMQSQSVKP 699
                P   ++  PSAG         S   + T L + ++   +    P  P   SQ  KP
Sbjct: 216  STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP-KP 274

Query: 700  ---QILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPP-PLKIHQVQHI 755
               Q L PP  V PP     P   P S+     P+P A    Q  APP  P   H     
Sbjct: 275  KGLQALRPPQ-VTPPRKDAAPALGPLSSSPLATPSPSAAL--QSQAPPTLPATPHSSSLT 331

Query: 756  TQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQA-----APP-----T 805
             Q+A P P  PP   AP   Q  P P  T P+  +T   +P +        +PP     T
Sbjct: 332  CQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 391

Query: 806  PTPPVPPAKKQPAFPASYIPP-SPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQ 864
            P P  PPA   P   A   PP SPP  P+  P P  P   +       +P SP PS    
Sbjct: 392  PPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAP--NALAVHLLQAPFSPPPS--PP 447

Query: 865  IASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFP--PPPPE 922
            + + F PP +PP   S       A    Q+PP++ A P   P S P   P  P   PPP+
Sbjct: 448  VQAPFSPPASPPVSPS-------ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 500

Query: 923  SSLVFPPP---PPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNS 979
            +    PPP   PP  +  PPP  PP A  TP     P        SP    P   P   S
Sbjct: 501  A----PPPLAAPPLQLAKPPPQAPP-ALATPPLQALP--------SPPASFPGQAPFSPS 547

Query: 980  SIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPG-KLNLSGVNLP 1038
            +    S    P P+ P V +      PP+   SP   TL  P  PP PG   ++SG  L 
Sbjct: 548  ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP---TLQAPRRPPTPGPDTSVSGPRLT 604

Query: 1039 GVLQQG---------CVSAKAPVLSGRGK------DSVVEFPSPPSDSDFPPPPPETELP 1083
              L  G           +   P L+G         + +  + S P       PPP+ EL 
Sbjct: 605  LALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA 664

Query: 1084 LPPIEIPAVFSGNTSPKVAV--VNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQ 1141
                  PA +S   +P +A       P  W        PP T P   D   L     +E 
Sbjct: 665  ACH---PAAWSRGPAPPLAFRGAPGAPLPW--------PPATGPGSADG--LCTIYETEG 711

Query: 1142 PTMATVVP 1149
            P  AT  P
Sbjct: 712  PESATPAP 719



 Score =  117 bits (293), Expect = 7e-26
 Identities = 166/666 (24%), Positives = 239/666 (35%), Gaps = 94/666 (14%)

Query: 621  ASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS 680
            A  P+   P    P PP  P PPPP  P   +   +AG+              + A    
Sbjct: 14   ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK-------PLAERAGGIG 66

Query: 681  GALFKPPTPPVMQSQSV-----KPQILVPPNGVVPPPPP-----PPPPPTPGSAMAQLKP 730
            GA      P    ++S       P    P +G     PP     P P  +PG A    +P
Sbjct: 67   GATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRP 126

Query: 731  APCAPSLPQFSA----------PPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK 780
             P      + SA            P             + PTP  P P  A     A  +
Sbjct: 127  GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 186

Query: 781  PLVTIPAPTS-----TKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPV 835
              +  PAP++     T+     V+ A+  + T P P A+++P+       P+  +     
Sbjct: 187  VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 246

Query: 836  PPPTLPKQQSFCAK-PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQS 894
             P + P +    A+  P +P  P     K + +  PP  TPP  ++ P    P + +P +
Sbjct: 247  TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLA 305

Query: 895  PPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG 954
             P+  A  + Q        P  P  P  SSL      P P+  P P  PP+    P    
Sbjct: 306  TPSPSAALQSQ------APPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPA 359

Query: 955  SPGKKTSKTSSPGGKKPPPTPQRNSSIKSS---SGAEHPEPKRPSVDSLVSKFTPPAESG 1011
            +P   +  T+S G     PT Q   S   S   S    P P+ P   +L     PP+   
Sbjct: 360  TP--PSQATTSLGS----PTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA 413

Query: 1012 SPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDS 1071
            SP       P A P P   N   V+L           +AP             PSPP  +
Sbjct: 414  SPPLS----PLATPSPQAPNALAVHL----------LQAPFSPP---------PSPPVQA 450

Query: 1072 DFPPP--PPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRND 1129
             F PP  PP +    PP + P   +   +P +  V P P     MS    PPP  P    
Sbjct: 451  PFSPPASPPVSPSATPPSQAPPSLA---APPLQ-VPPSPPASPPMSPSATPPPQAPPPLA 506

Query: 1130 STRLTQAEISEQ--PTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSR 1187
            +  L  A+   Q  P +AT   Q   SP +S   Q  F    +  +          L++ 
Sbjct: 507  APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM--------SPLATP 558

Query: 1188 MSRAEPTATMDDMALPPPP---PELLSDQQKAGYG-GSHISG-YATLRRGP-PPAPPKRD 1241
              +A P      + +PP P   P L + ++    G  + +SG   TL   P PP PP R 
Sbjct: 559  PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618

Query: 1242 QNTKLS 1247
             ++ LS
Sbjct: 619  PSSTLS 624



 Score =  117 bits (293), Expect = 7e-26
 Identities = 115/392 (29%), Positives = 138/392 (35%), Gaps = 68/392 (17%)

Query: 624 PSPPLPP---PPPPPPP----PP---PPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRL 673
           PSPPL P   PPP  PP    PP   PP PP  PPL   + PS  +   + V        
Sbjct: 382 PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 441

Query: 674 QNASQHSGALFKPP-TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAP 732
              S    A F PP +PPV  S S  P    PP+   PP   PP PP          P P
Sbjct: 442 PPPSPPVQAPFSPPASPPV--SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 499

Query: 733 CAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIP--APTS 790
            AP  P  +APP            Q+A P P  PP +  P P QA P P  + P  AP S
Sbjct: 500 QAP--PPLAAPP-----------LQLAKPPPQAPPALATP-PLQALPSPPASFPGQAPFS 545

Query: 791 TKTVAPVVTQAAPPTPTPPV--------PPAKKQPAFPASYIPPSPPTP----------- 831
                P+   A PP   PPV        PP+   PA P    P  PPTP           
Sbjct: 546 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSP--PASPTLQAPRRPPTPGPDTSVSGPRL 603

Query: 832 -----PVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPP------TPPAMES 880
                P P PPP+     +          S   S  +++      P        PP  E 
Sbjct: 604 TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL 663

Query: 881 QPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPP 940
               P   +  P  P A +  P       P+P P    P     L        P  A P 
Sbjct: 664 AACHPAAWSRGPAPPLAFRGAP-----GAPLPWPPATGPGSADGLCTIYETEGPESATPA 718

Query: 941 PPPPTASPTPDKSGSPGKKTSKTSSPGGKKPP 972
           P      P+P  SG  GK  +   +    + P
Sbjct: 719 PGALDPGPSPGTSG--GKAAAGAGAGASSRSP 748



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 95/414 (22%), Positives = 146/414 (35%), Gaps = 66/414 (15%)

Query: 842  KQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPP----------AMESQPLKPVPANVA 891
            K ++  A   P+  +P     +   S  PPPP  P          A+  +PL      + 
Sbjct: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66

Query: 892  PQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPP---TASP 948
              + P  ++ P+  P+     S   P   P +S      PP+   +P P   P   + + 
Sbjct: 67   GATIP--ESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT 124

Query: 949  TPDKSGSPGKKTSKTSSPGGKKPPPTPQRNS-SIKSSSGAEHPEPKRPSV---------- 997
             P   G  G + S   +    K    P+R++ S  +      P P  PS           
Sbjct: 125  RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184

Query: 998  -------DSLVSKFTPPAE-------SGSPSKETLPPPAAPPKPGKLNLSGVNLPG--VL 1041
                    +  ++  PP E       S S    T P PAA  +P      G+  P    L
Sbjct: 185  TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA--GGGLQRPASRSL 242

Query: 1042 QQGCVSAKAPVLSG---RGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTS 1098
                    +P  SG   RG       PS P         P    P      PA+   ++S
Sbjct: 243  SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 302

Query: 1099 PKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSS 1158
            P   +  P P      +++   PPT P    S+ LT         +AT +P  P SP + 
Sbjct: 303  P---LATPSP----SAALQSQAPPTLPATPHSSSLT-------CQLATPLPLAPPSPSAP 348

Query: 1159 LSVQPGFLADLNRTLQRKSITRHGSLSSRMSRA-EPTATMDDMALPPP--PPEL 1209
             S+Q   L     T   ++ T  GS + + + +  P+  +  +A PPP  PP L
Sbjct: 349  PSLQT--LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score =  144 bits (363), Expect = 5e-34
 Identities = 160/546 (29%), Positives = 214/546 (39%), Gaps = 110/546 (20%)

Query: 531  SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEES 590
            SS +K  SSS S     S+ S+ SDS  S+T+ A              ++ K+G    E 
Sbjct: 692  SSKMKGFSSSES---ESSSESSSSDSEDSETEMA-------------PKSKKKGHPGREQ 735

Query: 591  SKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPP-----PPPPPP 645
             K      +  +  +    +P P+           PP PP  PPPPPPP     PPPPPP
Sbjct: 736  KKHH----HHHHQQMQQAPAPVPQ----------QPPPPPQQPPPPPPPQQQQQPPPPPP 781

Query: 646  PPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPP---TPPVMQSQSVKPQIL 702
            PP +P Q+AP+  S+ P F+  + +  L+   Q  G++F P    T P++      PQ  
Sbjct: 782  PPSMPQQAAPAMKSSPPPFIA-TQVPVLE--PQLPGSVFDPIGHFTQPILH----LPQPE 834

Query: 703  VPPNGVVPPPPPPPP---------PPTPGSAMAQ--LKPAPCAPSLPQFSAPPPPLKIHQ 751
            +PP+   PP    PP         PP   +A+ Q   +P+  A +LP   A PP +    
Sbjct: 835  LPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPAL 894

Query: 752  VQHITQVAPPTPPPPPPIPAPLPPQAPP----------KPLVTIPAPTSTKTVAPVVTQA 801
             Q      PP   PP  +     P APP          + L  +  PT       V +Q 
Sbjct: 895  TQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQP 954

Query: 802  APPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSV 861
             PP P PP P  ++Q         P PP PP P PP   P+QQ    +PPP P+   P  
Sbjct: 955  PPPLPPPPHPSVQQQ-----LQQQPPPPPPPQPQPP---PQQQH---QPPPRPVHLQPMQ 1003

Query: 862  VKQIASQFPP-----PPTPPAMES----QPLKPVPANVAPQSPPAVKAKPKWQPSSIPVP 912
                  Q PP     PP PP  +     QP KP        SP   K+ P         P
Sbjct: 1004 FSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAP 1063

Query: 913  SPDFPPPPPES---SLVFPPPPPSPV--------PAPPPPPPPTASPTPDKSGSPGKKTS 961
            SP     P  S   SL    PP   V         A    P P      +K  SP  ++ 
Sbjct: 1064 SPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSE 1123

Query: 962  KTSSPGGKKPPPTPQRNSSIKSSSG-AEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPP 1020
              S     +PP  P+   SIK+     + PE K   V   V +         P ++  PP
Sbjct: 1124 PFSPSLRPEPPKHPE---SIKAPVHLPQRPEMKPVDVGRPVIR---------PPEQNAPP 1171

Query: 1021 PAAPPK 1026
            P AP K
Sbjct: 1172 PGAPDK 1177



 Score =  100 bits (250), Expect = 7e-21
 Identities = 130/507 (25%), Positives = 181/507 (35%), Gaps = 82/507 (16%)

Query: 750  HQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPP 809
            H  Q + Q   P P  PPP     PPQ PP P    P P           Q  PP P PP
Sbjct: 741  HHHQQMQQAPAPVPQQPPP-----PPQQPPPP----PPPQQQ--------QQPPPPPPPP 783

Query: 810  VPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQF 869
              P +  PA  +S  PP      VPV  P LP           S   P+    + I    
Sbjct: 784  SMPQQAAPAMKSS--PPPFIATQVPVLEPQLPG----------SVFDPIGHFTQPIL-HL 830

Query: 870  PPPPTPPAMESQPLKPVPANV---APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLV 926
            P P  PP +   P    P ++   A  SPPA+      QPS     +   PP P     V
Sbjct: 831  PQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAV 890

Query: 927  FPPPPPSPV-PAPPPPPPPTASPTPDKSGSPGKKTSKTS---SPGGKKPPPTPQRNS-SI 981
             P    +P+ P PP   PP      ++  +P   + +         K  PPTP   S  +
Sbjct: 891  SPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKV 950

Query: 982  KSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAA--PPKPGKLNLSGVNLPG 1039
            +S      P P  PSV   + +  PP     P  +  PPP     P P  ++L  +    
Sbjct: 951  QSQPPPPLPPPPHPSVQQQLQQQPPP----PPPPQPQPPPQQQHQPPPRPVHLQPMQFST 1006

Query: 1040 VLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLP-PIEIPAVFSGNTS 1098
             +QQ                     P PP     P PPP  + P P P +   V   + S
Sbjct: 1007 HIQQ---------------------PPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHS 1045

Query: 1099 PKVAVVNPQPQQWSKMSVKKAPPPT---RPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
            P+    +P    +S   +++AP P     P+ +    LT     + P    V P+     
Sbjct: 1046 PRHHKSDP----YSTGHLREAPSPLMIHSPQMSQFQSLTH----QSPPQQNVQPKKQELR 1097

Query: 1156 KSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQK 1215
             +S+ VQP  L  +        I R    S  + R EP    + +  P   P+   + + 
Sbjct: 1098 AASV-VQPQPLVVVKEEKIHSPIIRSEPFSPSL-RPEPPKHPESIKAPVHLPQ-RPEMKP 1154

Query: 1216 AGYGGSHISGYATLRRGPPPAPPKRDQ 1242
               G   I      +  PPP  P +D+
Sbjct: 1155 VDVGRPVIR--PPEQNAPPPGAPDKDK 1179



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 151/776 (19%), Positives = 237/776 (30%), Gaps = 145/776 (18%)

Query: 585  TQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP 644
            TQ  + +   +++   P+ ++ P L  Q    TP     P  PL  PPP PP P PPP P
Sbjct: 208  TQTPQPNPPPVQATPHPFPAVTPDLIVQ----TPVMTVVPPQPLQTPPPVPPQPQPPPAP 263

Query: 645  PPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS-GALFKPPTPPV--------MQSQ 695
             P P+ S     A +  P+  K     +    +  +   + +PP+ P          + +
Sbjct: 264  APQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRE 323

Query: 696  SVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHI 755
            S +P  + PP   VP     P P        QLK   C+  L +  A          +H 
Sbjct: 324  SSRP--VKPPKKDVPDSQQHPAPEKSSKVSEQLK--CCSGILKEMFAK---------KHA 370

Query: 756  TQVAP---PTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAA---------- 802
                P   P       +         P  + TI +    +         A          
Sbjct: 371  AYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCY 430

Query: 803  ---PPTPTPPVPPAKKQPAFPASY--IPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSP 857
               PP         K Q  F   +  +P  P  P V V  P +P      A P  S  S 
Sbjct: 431  KYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSS 490

Query: 858  VPSV----------------VKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAK 901
              S                 + ++  Q        A  SQP +  P           K K
Sbjct: 491  DSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEK 550

Query: 902  PKWQPSSIPVPSPDFPPPPPE-----SSLVFPPPPPSPVPAPPPPPPPTASPTPDK---- 952
             K +             PPP+     +S         P P    PPP   S   DK    
Sbjct: 551  HKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPM 610

Query: 953  ------------SGSPGKK-------------TSKTSSPGGKK------PPPTPQRNSSI 981
                        +  PG+K             + K S+P   +       P T +     
Sbjct: 611  SYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERY 670

Query: 982  KSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVL 1041
             +S   +  +P+   VD +         S S S+ +    ++  +  +  ++    P   
Sbjct: 671  VTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMA----PKSK 726

Query: 1042 QQGCVSAKAPVLSGRGKDSVVEFPSP-------PSDSDFPPPPPETELPLPPIEIPAVFS 1094
            ++G    +           + + P+P       P     PPPPP+ +   PP   P    
Sbjct: 727  KKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMP 786

Query: 1095 GNTSP------------KVAVVNPQ------------PQQWSKMSVKKAPP--PTRPKRN 1128
               +P            +V V+ PQ             Q    +   + PP  P  P+ +
Sbjct: 787  QQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHS 846

Query: 1129 DSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRM 1188
                L Q  +   P +   +PQ P+ P +  +  P   A         ++T+   L    
Sbjct: 847  TPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPA--RPPAVSPALTQTPLLPQPP 904

Query: 1189 SRAEPTATMDDMALPPPPPELLSDQ------QKAGYGGSHISGYATLRRGPPPAPP 1238
                P   ++D   P PP   +  Q      QK       +       + PPP PP
Sbjct: 905  MAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP 960



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 50/194 (25%), Positives = 65/194 (33%), Gaps = 25/194 (12%)

Query: 693 QSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQV 752
           ++ + KP +   PN      PP    P P     Q  P P     P      P       
Sbjct: 185 ETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTP------- 237

Query: 753 QHITQVAPPTP--PPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPV 810
             +  V PP P   PPP  P P PP A        PAP   ++  P++     P  T   
Sbjct: 238 --VMTVVPPQPLQTPPPVPPQPQPPPA--------PAPQPVQSHPPIIAATPQPVKTKKG 287

Query: 811 PPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFP 870
              K     P +  P   P    P P  T   Q+   ++P   P   VP       SQ  
Sbjct: 288 VKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPD------SQQH 341

Query: 871 PPPTPPAMESQPLK 884
           P P   +  S+ LK
Sbjct: 342 PAPEKSSKVSEQLK 355



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 46/151 (30%), Positives = 58/151 (38%), Gaps = 6/151 (3%)

Query: 874  TPPAMESQPLKPVPANVAPQSPPAVKAKPKWQ-PSSIPVPSPDFPPPPPESSLVFPPPPP 932
            TPP  ++    P P    P   PAV      Q P    VP      PPP      PPP P
Sbjct: 204  TPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAP 263

Query: 933  SPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGG----KKPPPTPQRNSSIKSSSGAE 988
            +P P    PP   A+P P K+    K+ + T++P       +PP  P    + K     E
Sbjct: 264  APQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRE 323

Query: 989  HPEP-KRPSVDSLVSKFTPPAESGSPSKETL 1018
               P K P  D   S+  P  E  S   E L
Sbjct: 324  SSRPVKPPKKDVPDSQQHPAPEKSSKVSEQL 354



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 55/192 (28%), Positives = 69/192 (35%), Gaps = 48/192 (25%)

Query: 749 IHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTP 808
           +  V + TQ + P P    P P P P QA P P    PA T    V   V    PP P  
Sbjct: 193 VSTVPNTTQASTP-PQTQTPQPNPPPVQATPHPF---PAVTPDLIVQTPVMTVVPPQPLQ 248

Query: 809 PVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ 868
             PP           +PP P  PP P P                    PV S    IA+ 
Sbjct: 249 TPPP-----------VPPQPQPPPAPAP-------------------QPVQSHPPIIAAT 278

Query: 869 FPPPPTPPAMESQPLKPVPANVAP-QSPPAVKAKPKW------QPSSIPV--PSPDFP-- 917
             P  T   ++ +     P  + P   PP++  +PK       + SS PV  P  D P  
Sbjct: 279 PQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDS 338

Query: 918 ---PPPPESSLV 926
              P P +SS V
Sbjct: 339 QQHPAPEKSSKV 350



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 50/168 (29%), Positives = 63/168 (37%), Gaps = 11/168 (6%)

Query: 791 TKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTP-PVPVPPPTLPKQQSFCAK 849
           T T  P V+   P T     PP   Q   P    PP   TP P P   P L  Q      
Sbjct: 186 TGTAKPGVS-TVPNTTQASTPP---QTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTV 241

Query: 850 PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQP--LKPVPANVAPQSPPAVKAKPKWQPS 907
            PP PL   P V  Q   Q PP P P  ++S P  +   P  V  +     KA      +
Sbjct: 242 VPPQPLQTPPPVPPQ--PQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT 299

Query: 908 SIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTAS--PTPDKS 953
             P+  P   PP P+++ +      S    PP    P +   P P+KS
Sbjct: 300 IDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKS 347



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 51/201 (25%), Positives = 68/201 (33%), Gaps = 50/201 (24%)

Query: 622 SQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSG 681
           ++P     P       PP    P P P P Q+ P                          
Sbjct: 189 AKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHP------------------------ 224

Query: 682 ALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPP---PPPTPGSAMAQLKPAPCAPSLP 738
             F   TP ++    V    +VPP  +  PPP PP   PPP P        P P     P
Sbjct: 225 --FPAVTPDLIVQTPV--MTVVPPQPLQTPPPVPPQPQPPPAPA-------PQPVQSHPP 273

Query: 739 QFSAPPPPLKIHQ-VQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPV 797
             +A P P+K  + V+       PT   P   P  LPP+  PK         S++ V P 
Sbjct: 274 IIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPE--PKTTKLGQRRESSRPVKP- 330

Query: 798 VTQAAPPTPTPPVPPAKKQPA 818
                   P   VP +++ PA
Sbjct: 331 --------PKKDVPDSQQHPA 343



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 42/183 (22%), Positives = 65/183 (35%), Gaps = 33/183 (18%)

Query: 973  PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNL 1032
            PT +    I  + G      +  +    VS      ++ +P +   P P  PP     + 
Sbjct: 165  PTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHP 224

Query: 1033 SGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPP-PPETELPLPPIEIPA 1091
                 P ++ Q       PV++      VV    PP     PPP PP+ + P  P   P 
Sbjct: 225  FPAVTPDLIVQ------TPVMT------VV----PPQPLQTPPPVPPQPQPPPAPAPQPV 268

Query: 1092 VFSGNTSPKVAVVNPQPQQWSKMSVKKA------------PPPTRPKRNDSTRLTQAEIS 1139
                 + P +    PQP +  K   +KA             PP+ P    +T+L Q   S
Sbjct: 269  ----QSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRES 324

Query: 1140 EQP 1142
             +P
Sbjct: 325  SRP 327



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 36/147 (24%), Positives = 51/147 (34%), Gaps = 34/147 (23%)

Query: 886  VPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPP-----PPSPVPAPPP 940
            VP      +PP  +     QP+  PV +   P P     L+   P     PP P+  PPP
Sbjct: 196  VPNTTQASTPPQTQTP---QPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPP 252

Query: 941  PPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSL 1000
             P     P P  + +P         P    PP        +K+  G      KR +  + 
Sbjct: 253  VP---PQPQPPPAPAP--------QPVQSHPPIIAATPQPVKTKKGV-----KRKADTTT 296

Query: 1001 VSKFTPPAESGSPSKETLPPPAAPPKP 1027
             +   P  E          PP+ PP+P
Sbjct: 297  PTTIDPIHE----------PPSLPPEP 313



 Score = 33.9 bits (76), Expect = 1.00
 Identities = 37/161 (22%), Positives = 64/161 (39%), Gaps = 30/161 (18%)

Query: 952  KSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPS------------VDS 999
            K    G+K + T+ PG    P T Q ++  ++ +   +P P + +            V +
Sbjct: 177  KGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQT 236

Query: 1000 LVSKFTPPAESGSP---SKETLPPPAAPPKPGKLN---LSGVNLPGVLQQGCVSAKAPVL 1053
             V    PP    +P     +  PPPA  P+P + +   ++    P   ++G V  KA   
Sbjct: 237  PVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKG-VKRKADTT 295

Query: 1054 SGRGKDSVVEFPSPP-----------SDSDFPPPPPETELP 1083
            +    D + E PS P            +S  P  PP+ ++P
Sbjct: 296  TPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVP 336


>gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score =  143 bits (360), Expect = 1e-33
 Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)

Query: 272 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 331
           V++V+  D + +++ V    T R V + L+ ++H      W LVE    L +ER  EDHE
Sbjct: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162

Query: 332 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 391
           ++VE    W     ++ +F +   KY LFK+  + L  +K  +   D +  +  E+    
Sbjct: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222

Query: 392 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 449
             ++ + PEI+G L L+  G+K WK+ +  LR SG+YY  KG +K  R L     ++  N
Sbjct: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282

Query: 450 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 509
           VY     R  Y  PTD+   +K  +++   + ++  C +D ++   W+   R+ KYG QL
Sbjct: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342

Query: 510 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 553
           Y NYQ+A  R       + L S  ++S S ++ +    S H+ +
Sbjct: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 21/69 (30%), Positives = 28/69 (40%), Gaps = 9/69 (13%)

Query: 870 PPPPTPPAMESQPLKPVPANVAPQSP---PAVKAKPKWQP------SSIPVPSPDFPPPP 920
           P P TPP     P  P+P  V    P   P    K + +        SIP P P+   PP
Sbjct: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPP 78

Query: 921 PESSLVFPP 929
            +S ++  P
Sbjct: 79  SQSPILGGP 87


>gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score =  143 bits (360), Expect = 1e-33
 Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)

Query: 272 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 331
           V++V+  D + +++ V    T R V + L+ ++H      W LVE    L +ER  EDHE
Sbjct: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162

Query: 332 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 391
           ++VE    W     ++ +F +   KY LFK+  + L  +K  +   D +  +  E+    
Sbjct: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222

Query: 392 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 449
             ++ + PEI+G L L+  G+K WK+ +  LR SG+YY  KG +K  R L     ++  N
Sbjct: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282

Query: 450 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 509
           VY     R  Y  PTD+   +K  +++   + ++  C +D ++   W+   R+ KYG QL
Sbjct: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342

Query: 510 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 553
           Y NYQ+A  R       + L S  ++S S ++ +    S H+ +
Sbjct: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 21/69 (30%), Positives = 28/69 (40%), Gaps = 9/69 (13%)

Query: 870 PPPPTPPAMESQPLKPVPANVAPQSP---PAVKAKPKWQP------SSIPVPSPDFPPPP 920
           P P TPP     P  P+P  V    P   P    K + +        SIP P P+   PP
Sbjct: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPP 78

Query: 921 PESSLVFPP 929
            +S ++  P
Sbjct: 79  SQSPILGGP 87


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score =  142 bits (358), Expect = 2e-33
 Identities = 175/645 (27%), Positives = 234/645 (36%), Gaps = 83/645 (12%)

Query: 536  SGSSSSSIPESQSNHSNQSDSG-VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKAR 594
            SG    + P   ++    S  G  S T   G +  + +  S   E   RG   E   ++ 
Sbjct: 88   SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA-EETVARGKATEAPKRSA 146

Query: 595  MESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSA 654
            + +  R  TS   P +P P +     A+     LP P P   P PP   P    + S S 
Sbjct: 147  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS-VSSASE 205

Query: 655  PSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSV--KPQILVPPNGVVPPP 712
             S    +P           +      G L +P +  +  S +    P    P     P  
Sbjct: 206  HSTTEPSPA---------ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA 256

Query: 713  PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPA- 771
            P  P  P P    A L+P    P     +    PL    +   +  APP+P  PP +   
Sbjct: 257  PAHPSQPKPKGLQA-LRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTL 315

Query: 772  PLPPQAPPKPLVT-IPAPT--STKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPP-S 827
            P PP  PP    T + +PT  +T +  P    +   TP P  PPA   P   A   PP S
Sbjct: 316  PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS 375

Query: 828  PPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVP 887
            PP  P+  P P  P   +       +P SP PS    + + F PP +PP   S       
Sbjct: 376  PPLSPLATPSPQAP--NALAVHLLQAPFSPPPS--PPVQAPFSPPASPPVSPS------- 424

Query: 888  ANVAPQSPPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFPPP---PPSPVPAPPPPP 942
            A    Q+PP++ A P   P S P   P  P   PPP++    PPP   PP  +  PPP  
Sbjct: 425  ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA----PPPLAAPPLQLAKPPPQA 480

Query: 943  PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVS 1002
            PP A  TP     P        SP    P   P   S+    S    P P+ P V +   
Sbjct: 481  PP-ALATPPLQALP--------SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL 531

Query: 1003 KFTPPAESGSPSKETLPPPAAPPKPG-KLNLSGVNLPGVLQQG---------CVSAKAPV 1052
               PP+   SP   TL  P  PP PG   ++SG  L   L  G           +   P 
Sbjct: 532  LQVPPSPPASP---TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD 588

Query: 1053 LSGRGK------DSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAV--V 1104
            L+G         + +  + S P       PPP+ EL       PA +S   +P +A    
Sbjct: 589  LAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACH---PAAWSRGPAPPLAFRGA 645

Query: 1105 NPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVP 1149
               P  W        PP T P   D   L     +E P  AT  P
Sbjct: 646  PGAPLPW--------PPATGPGSADG--LCTIYETEGPESATPAP 680



 Score =  120 bits (302), Expect = 6e-27
 Identities = 137/501 (27%), Positives = 170/501 (33%), Gaps = 91/501 (18%)

Query: 531 SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEES 590
           SS  +SG S+   P + ++ S     G+   +P         V+    +A      L  S
Sbjct: 241 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQ-------VTPPRKDAAPALGPLSSS 293

Query: 591 SKARMESMNRPYTSLVPPLS--PQPKIVTPYTASQ--------------PSPPLPP---P 631
             A       P  S  P L   P P    P  A+               PSPPL P   P
Sbjct: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 353

Query: 632 PPPPPP----PP---PPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALF 684
           PP  PP    PP   PP PP  PPL   + PS  +   + V           S    A F
Sbjct: 354 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 413

Query: 685 KPP-TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAP 743
            PP +PPV  S S  P    PP+   PP   PP PP          P P AP  P  +AP
Sbjct: 414 SPPASPPV--SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP--PPLAAP 469

Query: 744 PPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIP--APTSTKTVAPVVTQA 801
           P            Q+A P P  PP +  P P QA P P  + P  AP S     P+   A
Sbjct: 470 P-----------LQLAKPPPQAPPALATP-PLQALPSPPASFPGQAPFSPSASLPMSPLA 517

Query: 802 APPTPTPPV--------PPAKKQPAFPASYIPPSPPTP----------------PVPVPP 837
            PP   PPV        PP+   PA P    P  PPTP                P P PP
Sbjct: 518 TPPPQAPPVLAAPLLQVPPSP--PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 575

Query: 838 PTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPP------TPPAMESQPLKPVPANVA 891
           P+     +          S   S  +++      P        PP  E     P   +  
Sbjct: 576 PSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRG 635

Query: 892 PQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPD 951
           P  P A +  P       P+P P    P     L        P  A P P      P+P 
Sbjct: 636 PAPPLAFRGAP-----GAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG 690

Query: 952 KSGSPGKKTSKTSSPGGKKPP 972
            SG  GK  +   +    + P
Sbjct: 691 TSG--GKAAAGAGAGASSRSP 709



 Score =  120 bits (300), Expect = 1e-26
 Identities = 164/671 (24%), Positives = 230/671 (34%), Gaps = 113/671 (16%)

Query: 621  ASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS 680
            A  P+   P    P PP  P PPPP  P   +   +AG+              + A    
Sbjct: 14   ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRK-------PLAERAGGIG 66

Query: 681  GALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPP-----PPPPPTPGSAMAQLKPAPCAP 735
            GA      P    +++ +P    P +G     PP     P P  +PG A    +P P   
Sbjct: 67   GATIPESAPRAGPTRTSRP----PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ 122

Query: 736  SLPQFSA----------PPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTI 785
               + SA            P             + PTP  P P  A     A  +  +  
Sbjct: 123  KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 182

Query: 786  PAPTS-----TKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL 840
            PAP++     T+     V+ A+  + T P P A+++P+       P+  +      P + 
Sbjct: 183  PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSS 242

Query: 841  PKQQSFCAK-PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQP-LKPVPANVAPQSPPAV 898
            P +    A+  P +P  P     K + +  PP  TPP  ++ P L P+ ++      P+ 
Sbjct: 243  PARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSA 302

Query: 899  KAKPKWQPSSIPVPSPDFPPPPPESSLV-----------FPPPPPSPVPAPPPPPPPTAS 947
               P   PS   +PSP   PP   ++ +            P PP SP+  PPP  PP A 
Sbjct: 303  PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPP-AL 361

Query: 948  PTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPP 1007
              P     P    S   SP     P  P  N+       A    P  P V    + F+PP
Sbjct: 362  ALPPLQAPPSPPASPPLSPLATPSPQAP--NALAVHLLQAPFSPPPSPPVQ---APFSPP 416

Query: 1008 AESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSP 1067
            A S   S    PP  APP      L     P        SA  P        +     +P
Sbjct: 417  A-SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP------PQAPPPLAAP 469

Query: 1068 PSDSDFPPPPPETELPLPPIEI----PAVFSGNT--SPKVAVVNPQPQQWSKMSVKKAPP 1121
            P     PPP     L  PP++     PA F G    SP  ++          MS    PP
Sbjct: 470  PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL---------PMSPLATPP 520

Query: 1122 PTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRH 1181
            P  P                P +A  + QVP SP +S ++Q              +  R 
Sbjct: 521  PQAP----------------PVLAAPLLQVPPSPPASPTLQ--------------APRRP 550

Query: 1182 GSLSSRMSRAEPTATMDDMALPPPPP-----ELLSDQQKAGYGGS------HISGYATLR 1230
             +     S + P  T+     PPPPP       LS    AG+  S       + GY +  
Sbjct: 551  PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGP 610

Query: 1231 RGPPPAPPKRD 1241
             G   A P  D
Sbjct: 611  EGGAAASPPPD 621



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 107/457 (23%), Positives = 148/457 (32%), Gaps = 107/457 (23%)

Query: 842  KQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM----------------------- 878
            K ++  A   P+  +P     +   S  PPPP  PA                        
Sbjct: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66

Query: 879  -----ESQP-LKPVPANVAPQSPPAVKAKPKWQPSSIPVPSP------DFPPP------- 919
                 ES P   P   +  P S    +A P    S  PV SP        P P       
Sbjct: 67   GATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR 126

Query: 920  ---------------PPESSL-------VFPPPPPSPVPAPP------------PPPPPT 945
                           P  S+L          P P +P PA              P P P+
Sbjct: 127  ISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 186

Query: 946  ASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFT 1005
            A P P   G P K  S  S     +P P  +R    + S+G     P   S+ S  +  +
Sbjct: 187  ARPRPPTEG-PRKSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRSLSSSATPLS 241

Query: 1006 PPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFP 1065
             PA SG  ++ T   PA P +P    L  +  P V         AP L G    S +  P
Sbjct: 242  SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR--KDAAPAL-GPLSSSPLATP 298

Query: 1066 SPPSDSDFPPPPPETELPLPPIEIP-------------AVFSGNTSPKVA-VVNPQPQQW 1111
            SP +      PP    LP PP   P             A  S   SP ++ +  P PQ  
Sbjct: 299  SPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 358

Query: 1112 SKMSVKK-APPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLN 1170
              +++     PP+ P     + L          +A  + Q P SP  S  VQ  F    +
Sbjct: 359  PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 418

Query: 1171 RTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207
              +           ++  S+A P+     + +PP PP
Sbjct: 419  PPVSPS--------ATPPSQAPPSLAAPPLQVPPSPP 447


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score =  141 bits (355), Expect = 4e-33
 Identities = 164/591 (27%), Positives = 229/591 (38%), Gaps = 129/591 (21%)

Query: 612  QPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTIT 671
            +P++  P     P  P P   P  PPP   P  PPP     S P     A         +
Sbjct: 427  EPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPA---------S 477

Query: 672  RLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPA 731
             L  A   S  L + P  P                   PP   P  PP   S  + L+ +
Sbjct: 478  PLPEALHLSRPLEESPLSP-------------------PPEESPLSPPPESSPFSPLEES 518

Query: 732  PCAPSLPQFSAPPPPLKIHQVQHITQVAPP---TPPPPPPIPAPLPPQAPPKPLVTIPAP 788
            P +P  P+ S P P L+       T ++PP   +P  PP   +PL P  PP+ L T P P
Sbjct: 519  PLSP--PEESPPSPALE-------TPLSPPPEASPLSPPFEESPLSP--PPEELPTSPPP 567

Query: 789  TSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPS-----PPTPPVPVPPPTLPKQ 843
             +++        + PP  +P  PP ++ P  P    PP      PP    P+ PP     
Sbjct: 568  EASRL-------SPPPEESPMSPPPEESPMSP----PPEASRLFPPFEESPLSPP----- 611

Query: 844  QSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPK 903
                  P  SPLSP P      AS+  PPP     E  P+ P P   +P SPP   ++  
Sbjct: 612  ------PEESPLSPPPE-----ASRLSPPP-----EDSPMSP-PPEESPMSPPPEVSR-- 652

Query: 904  WQPSSIPVPSPDFPP-------PPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSP 956
               S +PV S   PP       PPPE S   PPP  S + +PPP   PT+ P  D   SP
Sbjct: 653  --LSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRL-SPPPEDSPTSPPPEDSPASP 709

Query: 957  GKKTSKTSSPGGKKP-PPTPQRNSSIKSSSGAE-HPEPKRPSVDSLVSK--FTPPAES-- 1010
              + S  S P  + P  P P+       S G    P P+ P +     +   +P AE   
Sbjct: 710  PPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPH 769

Query: 1011 -----------GSPSKETLPP----PAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSG 1055
                         P +  L P    P   P+P +L+LS       L       + P LS 
Sbjct: 770  LSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSP---VPEEPCLSP 826

Query: 1056 RGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQW-SKM 1114
            + ++S +   SP S+     P PE     P +E P +     SP+      +P Q  +  
Sbjct: 827  QPEESHL---SPQSEEPCLSPRPEESHLSPELEKPPL-----SPRPEKPPEEPGQCPAPE 878

Query: 1115 SVKKAPPPTRPKRNDSTRLTQAEISE--QPTMATVVPQVPTSPKSSLSVQP 1163
             +   PPP  P    S  L +  +SE  +P ++ +  ++P SP    S+ P
Sbjct: 879  ELPLFPPPGEPSL--SPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSP 927



 Score =  134 bits (336), Expect = 7e-31
 Identities = 154/570 (27%), Positives = 213/570 (37%), Gaps = 95/570 (16%)

Query: 587  LEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPP------ 640
            LEES  +  E  + P  +L  PLSP P+        + SP  PPP   P  PPP      
Sbjct: 515  LEESPLSPPEE-SPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLS 573

Query: 641  PPP------PPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQS 694
            PPP      PPP   P    P A    P F                  L  PP    +  
Sbjct: 574  PPPEESPMSPPPEESPMSPPPEASRLFPPF--------------EESPLSPPPEESPLSP 619

Query: 695  QSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCA------PSLPQFSAPPPPLK 748
                 ++  PP      PPP   P +P   +++L P P        P     S PP    
Sbjct: 620  PPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESP 679

Query: 749  IHQVQHITQVAPP---TPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPT 805
                   ++++PP   +P  PPP  +P  P  P   L+++P   S     P   Q  P +
Sbjct: 680  TSPPPEASRLSPPPEDSPTSPPPEDSPASP-PPEDSLMSLPLEESPLLPLPEEPQLCPRS 738

Query: 806  PTPPVPPAKKQPAF-PASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPV---PSV 861
              P + P  ++P   P    P   P    P   P  P++   CA P    LSP    P +
Sbjct: 739  EGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQ-PEEPCLCAVPEEPHLSPQAEGPHL 797

Query: 862  VKQ-----IASQFPPPPTPPAMESQPLKPVP--ANVAPQS-PPAVKAKPKWQPSSIPV-- 911
              Q     ++ Q   P   P  E   L P P  ++++PQS  P +  +P+    S  +  
Sbjct: 798  SPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEK 857

Query: 912  ----PSPDFPP------PPPESSLVFPPP------PPSPVPAPPPPPPPTASPTPDK--- 952
                P P+ PP      P PE   +FPPP      P    PA   P  P  SP P++   
Sbjct: 858  PPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPL 917

Query: 953  --SGSPGKKTSKTSSPGGKKPPP-----TPQRNSSIKSSSGAEHP-------EPKRP-SV 997
              SG P    S    P    PPP     T     ++      E+P       +P+ P + 
Sbjct: 918  SPSGEP--SLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAA 975

Query: 998  DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRG 1057
              L +  +PP E+     E +PP   PP PG  +  G   P +L +      +P+L    
Sbjct: 976  PILETPISPPPEANCTDPEPVPPMILPPSPG--SPVGPASP-ILMEPLPPQCSPLL---- 1028

Query: 1058 KDSVVEFPSPPSDSDFPPPPPETELPLPPI 1087
            + S+V   SPPS    P  P     PL PI
Sbjct: 1029 QHSLVPQNSPPSQCSPPALPLSVPSPLSPI 1058



 Score =  131 bits (330), Expect = 4e-30
 Identities = 180/688 (26%), Positives = 256/688 (37%), Gaps = 131/688 (19%)

Query: 608  PLSPQPKI--VTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFV 665
            PLSP P+   ++P   S P  PL   P  PP   PP P    PL     P A   +P F 
Sbjct: 493  PLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPL--SPPPEASPLSPPF- 549

Query: 666  KYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPP---PPPPPPTPG 722
                       S  S    + PT P  ++  + P    P    + PPP   P  PPP   
Sbjct: 550  ---------EESPLSPPPEELPTSPPPEASRLSPP---PEESPMSPPPEESPMSPPPEAS 597

Query: 723  SAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPP---TPPPPPPIPAPLPPQAPP 779
                  + +P +P   +    PPP         ++++PP   +P  PPP  +P+ P    
Sbjct: 598  RLFPPFEESPLSPPPEESPLSPPP-------EASRLSPPPEDSPMSPPPEESPMSP---- 646

Query: 780  KPLVTIPAPTSTKTVAPVVTQAAPPTPTPPV-PPAKKQPAFP---ASYIPP----SPPTP 831
                  P   S  +  PVV++ +PP    P+ PP ++ P  P   AS + P    SP +P
Sbjct: 647  ------PPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSP 700

Query: 832  PVPVPPPTLPKQQSFCAKP-PPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVP--A 888
            P    P + P + S  + P   SPL P+P    Q+  +   P   P  E   L P P   
Sbjct: 701  PPEDSPASPPPEDSLMSLPLEESPLLPLPE-EPQLCPRSEGPHLSPRPEEPHLSPRPEEP 759

Query: 889  NVAPQS-PPAVKAKPKWQPSSIPVP-SPDFPP--------PPPESSLVFP---PPPPSPV 935
            +++PQ+  P +  +P+ +P    VP  P   P        P PE   + P    P  SPV
Sbjct: 760  HLSPQAEEPHLSPQPE-EPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPV 818

Query: 936  PAPP---PPP----------PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIK 982
            P  P   P P           P  SP P++S    +      SP  +KPP  P +  + +
Sbjct: 819  PEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPE 878

Query: 983  SSSGAEHPEPKRPSVDSLVSK--FTPPAESG-SPSKETLP-PPAAPPKPGKLNLSGVNLP 1038
                   P P  PS+  L+ +   + P E   SP  E LP  P+  P      +    LP
Sbjct: 879  EL--PLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLP 936

Query: 1039 GVLQQGCVSAKAPVLSGRGK---------DSVVEFP----------SPPSDSDFPPPPPE 1079
              L     +A  P LS  G+         DS  E P          SPP +++   P P 
Sbjct: 937  PPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPV 996

Query: 1080 TELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRL------ 1133
              + LPP   P    G  SP   ++ P P Q S +      P   P    S         
Sbjct: 997  PPMILPP--SPGSPVGPASP--ILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVP 1052

Query: 1134 -------------TQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITR 1180
                          +AE+ E  T     P+ P    S+ S  P  + DL+      +   
Sbjct: 1053 SPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAPSPA--- 1109

Query: 1181 HGSLSSRMSRAEPTATMDDMALPPPPPE 1208
              +L       E TA +D +  P   PE
Sbjct: 1110 -PALDDFSGLGEDTAPLDGIDAPGSQPE 1136



 Score =  103 bits (256), Expect = 1e-21
 Identities = 154/639 (24%), Positives = 220/639 (34%), Gaps = 106/639 (16%)

Query: 601  PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSA 660
            P  S + PL    ++  P   S  SPP    P  PPP      PPP   P+   P    A
Sbjct: 648  PEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPA 707

Query: 661  APMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720
            +P          L +       L   P  P +  +S  P +   P      P P  P  +
Sbjct: 708  SP-----PPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLS 762

Query: 721  PGSAMAQLKPAPCAPSL----------PQFSAP---PPPLKIHQVQHITQVAPPTPPPPP 767
            P +    L P P  P L          PQ   P   P P ++H +   T+    +P P  
Sbjct: 763  PQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELH-LSPQTEEPHLSPVPEE 821

Query: 768  PIPAPLPPQAPPKPLVTIP--APTSTKTVAPVVTQAAPPTPTPPVPP--------AKKQP 817
            P  +P P ++   P    P  +P   ++      +  P +P P  PP         ++ P
Sbjct: 822  PCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELP 881

Query: 818  AFPASYIPPSPP--TPPVPVPPPTLPKQQSFCAKPPPSPLSP--VPSVVKQIASQFPPPP 873
             FP    PP  P  +P +  P  + P +      P   PLSP   PS+  Q+    PP P
Sbjct: 882  LFP----PPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQL---MPPDP 934

Query: 874  TPPAMESQPLKPVPANVAP------------------QSPPAVKAKPKWQPSSIPVPSPD 915
             PP     PL P+    AP                    P +  A P  +    P P  +
Sbjct: 935  LPP-----PLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEAN 989

Query: 916  FPPPPPESSLVFPPPPPSPV-PAPP---PPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP 971
               P P   ++ PP P SPV PA P    P PP  SP    S  P     + S P    P
Sbjct: 990  CTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVP-----QNSPPSQCSP 1044

Query: 972  PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLN 1031
            P  P    S  S  G          +  + ++     +   P    L P A  P P  + 
Sbjct: 1045 PALPLSVPSPLSPIGKVVGVSDEAELHEMETE-----KVSEPECPALEPSATSPLPSPMG 1099

Query: 1032 LSGVNLPGVLQQGCVSAKAPVL---SGRGKDSV----VEFPSPPSDSDFPPPPPETELP- 1083
                  P         + AP L   SG G+D+     ++ P    +    P    +EL  
Sbjct: 1100 DLSCPAP---------SPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELKG 1150

Query: 1084 ----LPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAP----PPTRPKR---NDSTR 1132
                L P E+  V      P+      Q     +    +AP    PPT  K    N+ + 
Sbjct: 1151 SPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISN 1210

Query: 1133 LTQAEISEQ-PTMATVVPQVPTSPKSSLSVQPGFLADLN 1170
            L+Q + S   P    ++         SLS++ G   D++
Sbjct: 1211 LSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVS 1249



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 171/673 (25%), Positives = 232/673 (34%), Gaps = 108/673 (16%)

Query: 610  SPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYST 669
            S  P  + P    +P  P  PP  PP P P   P  PP L + S P AG           
Sbjct: 2173 SQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPG 2232

Query: 670  ITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLK 729
              R Q ++      F  P  P + + +V P+      G    P   PPP        ++K
Sbjct: 2233 TPRHQPSTPDP---FLKPRCPSLDNLAV-PESPGVGGGKASEPLLSPPPFGESRKALEVK 2288

Query: 730  PAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQA----PPKPLVTI 785
                  S P +  PP    +      T +       P    APL P+A    P  P + +
Sbjct: 2289 KEELGASSPSY-GPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGL 2347

Query: 786  PAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPP--SPPTPPVPVPPPTLPKQ 843
                  +   P   QA  P+     PP+      P SY  P   PP  P P PPP     
Sbjct: 2348 ------RPQEPPPAQALAPS-----PPSHPDIFRPGSYTDPYAQPPLTPRPQPPP----P 2392

Query: 844  QSFCAKPPPS-PLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKP 902
            +S CA PP S P  P         S+ P  P   +    PL P P +     P  V   P
Sbjct: 2393 ESCCALPPRSLPSDPF--------SRVPASPQSQSSSQSPLTPRPLSAEAFCPSPV--TP 2442

Query: 903  KWQPSSIPVPSP-DFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTS 961
            ++Q      P P   PP  P+S       P +P+  PP P PP  +    K+GS     +
Sbjct: 2443 RFQS-----PDPYSRPPSRPQSR-----DPFAPLHKPPRPQPPEVA---FKAGS----LA 2485

Query: 962  KTSSPGGKKP---PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVS-----KFTPPAESGSP 1013
             TS   G  P   P  P      K  SG      + P   + V      +FT P   G P
Sbjct: 2486 HTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEP 2545

Query: 1014 S-KETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGR---------------G 1057
            S K  +P P  PP  G  +  G   PG       S    V +G                G
Sbjct: 2546 SLKPPVPQPGLPPPHGINSHFG---PGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTG 2602

Query: 1058 KDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVK 1117
            +   +    PP  S  PPP P+  LP       +  SG TSP     +P     S ++  
Sbjct: 2603 ESYGLSPLRPP--SVLPPPAPDGSLPYLS-HGASQRSGITSPVEKREDPGTGMGSSLATA 2659

Query: 1118 KAPPPTRP-----------KRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSV-QPGF 1165
            + P    P           K+    RL +  I +Q    T+  +  T+  ++ +V  PG 
Sbjct: 2660 ELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGS 2719

Query: 1166 LADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISG 1225
                  +   + ++R         +     T D  +L   PP  LS       G      
Sbjct: 2720 WGAEPSSPAFEQLSR--------GQTPFAGTQDKSSLVGLPPSKLSGPI---LGPGSFPS 2768

Query: 1226 YATLRRGPPPAPP 1238
               L R PPPA P
Sbjct: 2769 DDRLSRPPPPATP 2781



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 97/355 (27%), Positives = 138/355 (38%), Gaps = 46/355 (12%)

Query: 865  IASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESS 924
            + S  P  P P   E++PL      + PQ    ++A    +   +P P      PPPE S
Sbjct: 401  VTSMQPKEPGPLQCEAKPLGKAGVQLEPQ----LEAPLNEEMPLLPPPEESPLSPPPEES 456

Query: 925  LVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSS 984
               PPP  S +   PPP    ASP P+             SP  ++ P +P   SS    
Sbjct: 457  PTSPPPEASRL--SPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESS---- 510

Query: 985  SGAEHPEPKRPSVDSLVSKFTPPAES-GSPSKET--LPPPAAPPKPGKLNLSGVNLPGVL 1041
                   P  P  +S +S   PP ES  SP+ ET   PPP A P       S ++ P   
Sbjct: 511  -------PFSPLEESPLS---PPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEE 560

Query: 1042 QQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKV 1101
                   +A  LS   ++S +   SPP +     PPPE     PP E   +   +  P+ 
Sbjct: 561  LPTSPPPEASRLSPPPEESPM---SPPPEESPMSPPPEASRLFPPFEESPL---SPPPEE 614

Query: 1102 AVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSV 1161
            + ++P P+  S++S      P  P   +S      E+S    +  V    P   +S LS 
Sbjct: 615  SPLSPPPEA-SRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSP 673

Query: 1162 QPGFLADLNRTLQRKSITRHGSLSSRMS---RAEPTA--TMDDMALPPPPPELLS 1211
             P            +S T     +SR+S      PT+    D  A PPP   L+S
Sbjct: 674  PP-----------EESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMS 717



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 121/483 (25%), Positives = 152/483 (31%), Gaps = 135/483 (27%)

Query: 709  VPPPP----PPPPPPTPGSAMAQ-LKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTP 763
            +PP P     PPP   P   +     PA  + S   F  PP             V  P  
Sbjct: 2106 IPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAG----------SVPGPDS 2155

Query: 764  PP------PPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP---AK 814
            P       PP +PA +P Q P       P      T  P       PT  P  PP   A 
Sbjct: 2156 PGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGAS 2215

Query: 815  KQPAF--PASYIPPSPPTP------PVPVPPPTLPKQQSFCAKPPPSP-----------L 855
             +P    P  +    P TP      P P   P  P   +     P SP           L
Sbjct: 2216 SRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAV--PESPGVGGGKASEPLL 2273

Query: 856  SPVP--------SVVKQIASQFPPPPTPPAME----------------------SQPLKP 885
            SP P         V K+      P   PP +                         PL P
Sbjct: 2274 SPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTP 2333

Query: 886  VPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPP---------PPPSPVP 936
              + V PQS P +  +P+  P     P+    P PP    +F P         PP +P P
Sbjct: 2334 RASQVEPQS-PGLGLRPQEPP-----PAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRP 2387

Query: 937  APPPPP-----PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPE 991
             PPPP      PP + P+   S  P    S++SS     P P          S+ A  P 
Sbjct: 2388 QPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPL---------SAEAFCPS 2438

Query: 992  PKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKP---------GKL---NLSGVNLPG 1039
            P  P   S      PP  S   S++   P   PP+P         G L   +L     P 
Sbjct: 2439 PVTPRFQSPDPYSRPP--SRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPA 2496

Query: 1040 VLQQGC---VSAKAP------VLSGRGKDSVVEFPSP--------PSDSDFPPPPPETEL 1082
             L  G    + AK P       +   G  + V  PSP          +    PP P+  L
Sbjct: 2497 ALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGL 2556

Query: 1083 PLP 1085
            P P
Sbjct: 2557 PPP 2559



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 94/360 (26%), Positives = 123/360 (34%), Gaps = 102/360 (28%)

Query: 828  PPTPPVPVPPPTLPKQQSFCAKPP-PSPLSP-VPSVVKQIASQFPPPPTPPAMESQPLKP 885
            PP P     PP       F   P  P+ LS      +K  A   P P +P  +  +    
Sbjct: 2107 PPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQ 2166

Query: 886  VPANVAPQSP----PAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPP 941
            VPA V  Q P    PA   +P+            FP  PP       PP PSP  AP  P
Sbjct: 2167 VPAQVPSQDPFGLAPAYPLEPR------------FPTAPPTY-----PPYPSPTGAPAQP 2209

Query: 942  PPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLV 1001
            P   AS  P  +G PG+  +         PP TP+   S          +P+ PS+D+L 
Sbjct: 2210 PMLGASSRPG-AGQPGEFHTT--------PPGTPRHQPSTPDP----FLKPRCPSLDNLA 2256

Query: 1002 SKFTPPAESGSPSKETLPPP-----------------AAPPKPGKLNL-------SGVNL 1037
               +P    G  S+  L PP                 A+ P  G  NL       SG +L
Sbjct: 2257 VPESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHL 2316

Query: 1038 PGVL-------------QQGCVSAKAPVLSGRGKD---SVVEFPSPPSDSDF-------- 1073
             G+              +   V  ++P L  R ++   +    PSPPS  D         
Sbjct: 2317 GGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTD 2376

Query: 1074 -----------PPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPP 1122
                        PPPPE+   LPP  +P       S   + V   PQ  S       P P
Sbjct: 2377 PYAQPPLTPRPQPPPPESCCALPPRSLP-------SDPFSRVPASPQSQSSSQSPLTPRP 2429



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 103/406 (25%), Positives = 136/406 (33%), Gaps = 93/406 (22%)

Query: 601  PYTSLVPPLSPQPKIVTP--YTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAG 658
            P  +L P     P I  P  YT     PPL P P PPPP      PP      +S PS  
Sbjct: 2354 PAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPP------RSLPS-- 2405

Query: 659  SAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPP 718
                        +R+  + Q   +   P TP  + +++  P  + P      P   PP  
Sbjct: 2406 ---------DPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSR 2456

Query: 719  PTPGSAMAQLKPAPCAPSLPQFSAPPPP---LKIHQVQHITQVAPPTPPPPPPIPAPLPP 775
            P      A L   P          P PP    K   + H +  A          PA LP 
Sbjct: 2457 PQSRDPFAPLHKPP---------RPQPPEVAFKAGSLAHTSLGA-------GGFPAALPA 2500

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPV 835
                +    +P+      V    T A   TP+P       +  FP +   PS   PPVP 
Sbjct: 2501 GPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSP------MRFTFPQAVGEPS-LKPPVPQ 2553

Query: 836  PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSP 895
            P             PPP  ++          S F P PT                 PQS 
Sbjct: 2554 P-----------GLPPPHGIN----------SHFGPGPTLG--------------KPQST 2578

Query: 896  PAVKAKPKWQPSSIPV-PSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG 954
                A   + PS  P+ PS        ES  + P  PPS +   PPP P  + P      
Sbjct: 2579 NYTVATGNFHPSGSPLGPSSG---STGESYGLSPLRPPSVL---PPPAPDGSLPYLSHGA 2632

Query: 955  SPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSL 1000
            S   + S  +SP  K+  P     SS+ +   AE P  + P +  L
Sbjct: 2633 S---QRSGITSPVEKREDPGTGMGSSLAT---AELPGTQDPGMSGL 2672



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 166/788 (21%), Positives = 260/788 (32%), Gaps = 121/788 (15%)

Query: 545  ESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTS 604
            + Q     Q    +   Q     + Q +      +  ++  QL++  + + +   +    
Sbjct: 3913 QQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQ 3972

Query: 605  LVPPLSPQPK-IVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPM 663
                L  Q + +++P    Q    L P  P  P      P    P    +     +  P 
Sbjct: 3973 QQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPA 4032

Query: 664  FVKYSTITRLQNASQHSG---ALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720
                +T    +  S H G   A+   P     +   VKP +      ++  P P P P +
Sbjct: 4033 VSSEAT----EGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSS 4088

Query: 721  ---------PGSAMAQLK----------------PAPCAPSLPQFSAPPPPLKIHQVQHI 755
                     PG    Q+                  +  A S+P   A P      Q   +
Sbjct: 4089 LQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSM 4148

Query: 756  TQ--VAPPTPP----------PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAP 803
            TQ  + P  P           P PP P P+       P V I  PT  +  A +    A 
Sbjct: 4149 TQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGI-MPTVGQLRAQLQGVLAK 4207

Query: 804  PTPTPPVPPAKKQPAFPASYIPPSPPTPPV-PVPPPTLPKQQSFCAKPPPSPLSPVPSVV 862
                  + P ++Q             +  V   PP   P  Q+       SPL  +    
Sbjct: 4208 NPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQT-------SPLQGLLGCQ 4260

Query: 863  KQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPE 922
             Q+   FP P T P  E      + A   PQ PP + A P    S+ PV  P  P PPP 
Sbjct: 4261 PQLGG-FPGPQTGPLQE------LGAGPRPQGPPRLPAPPG-ALSTGPVLGPVHPTPPPS 4312

Query: 923  SSLVFPPPPPSPVPAP-----------------PPPPPPTASPTPDKSGSPGKKTSKTSS 965
            S     P  PS +P+P                 P P  PT  P P +      + + T  
Sbjct: 4313 SPQ--EPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLF 4370

Query: 966  PGGKKP--PP-------TPQRNSSIKSS----SGAEHPEPKRPSVDSLVSKFTPPAESGS 1012
              G  P  PP        P+++S +       +G   PE  + S+     +      + S
Sbjct: 4371 SKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQS 4430

Query: 1013 PSKETLPPP-AAPPKPGKLNLSGVNLPG--VLQQGCVSAKAPVLS-GRGKDSVVEFPSPP 1068
              +E    P  AP     L L+G       +L Q  + AK   LS GRG + +    +  
Sbjct: 4431 VKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGH 4490

Query: 1069 SDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVA--VVNPQPQQWSKMSVKKAPPPTRPK 1126
             DS       E +L   P         N     A   + P+P++  K S +      + +
Sbjct: 4491 IDSKL--AGLEQKLQGTP--------SNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLR 4540

Query: 1127 RNDSTRLTQAEISEQPTMATVVP--QVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSL 1184
            + D  R ++A + +     +++P  +   +   SL    G    +N   Q +     G+L
Sbjct: 4541 KEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGAL 4600

Query: 1185 SSRMSRAEPTATMDDMALPPPPPELL------SDQQKAGYGGSHISGYATLRRGPPPAPP 1238
             +         T ++++ PP PP  L      S QQK   G   ++    L   P  A  
Sbjct: 4601 PTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNG---VTPSEELGEHPKDAAS 4657

Query: 1239 KRDQNTKL 1246
             RD    L
Sbjct: 4658 ARDSERAL 4665



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 95/423 (22%), Positives = 140/423 (33%), Gaps = 73/423 (17%)

Query: 593  ARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPP--------P 644
            +R+ +  +  +S   PL+P+P     +  S  +P    P P   PP  P           
Sbjct: 2409 SRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHK 2468

Query: 645  PPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVP 704
            PP P P + A  AGS             L + S  +G    P   P   +  +       
Sbjct: 2469 PPRPQPPEVAFKAGS-------------LAHTSLGAGGF--PAALPAGPAGEL------- 2506

Query: 705  PNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPP 764
             +  VP   PP    +PG+      P+P   + PQ    P             + PP P 
Sbjct: 2507 -HAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEP------------SLKPPVPQ 2553

Query: 765  PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYI 824
            P  P P  +     P P  T+  P ST     V T    P+ + P+ P+           
Sbjct: 2554 PGLPPPHGINSHFGPGP--TLGKPQSTNYT--VATGNFHPSGS-PLGPSSGSTGESYGLS 2608

Query: 825  PPSPPTP-PVPVPPPTLP------KQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPA 877
            P  PP+  P P P  +LP       Q+S    P      P   +   +A+   P    P 
Sbjct: 2609 PLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPG 2668

Query: 878  MESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPA 937
            M       +      Q    +  + + Q +++     +       +  V PP      P+
Sbjct: 2669 MSGLSQTELEKQRQRQRLRELLIRQQIQRNTL---RQEKETAAAAAGAVGPPGSWGAEPS 2725

Query: 938  PPPPPPPTASPTP-----DKSGSPGKKTSKTSSP---GGKKP-------PPTPQRNSSIK 982
             P     +   TP     DKS   G   SK S P    G  P       PP P   SS+ 
Sbjct: 2726 SPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMD 2785

Query: 983  SSS 985
             +S
Sbjct: 2786 VNS 2788



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 63/242 (26%), Positives = 85/242 (35%), Gaps = 42/242 (17%)

Query: 560  DTQPAGHVRSQSIVSSVFSEAWKRGTQLEES-----SKARMESMNRPYTSLVPPLSPQPK 614
            DT+P G +  + +   +    W++G   E S     S A  +++N    ++   LS   K
Sbjct: 4754 DTKPYGALGLE-VPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSM--K 4810

Query: 615  IVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAG--------SAAPMFVK 666
            I   Y    P  P      P       P      L  +S P  G        +  P +  
Sbjct: 4811 IPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKS-PDTGPDWLKQFDAVLPGYTL 4869

Query: 667  YSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMA 726
             S +  L    Q S A    P PP   S +     L       PPP  P PPP+P     
Sbjct: 4870 KSQLDILSLLKQESPA----PEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSP----- 4920

Query: 727  QLKPAPCA-PSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIP-APLPPQAPPKPLVT 784
             L P+P + P+ P    P  PL               PP P P+P A  P  A PKP   
Sbjct: 4921 -LAPSPASPPTEPLVELPTEPL-------------AEPPVPSPLPLASSPESARPKPRAR 4966

Query: 785  IP 786
             P
Sbjct: 4967 PP 4968



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 89/382 (23%), Positives = 127/382 (33%), Gaps = 62/382 (16%)

Query: 630  PPPPPPPPPPPPPPPPPPPL-----PSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALF 684
            PP PP   PP PPP     +     PS+        A          R  +  +    L 
Sbjct: 4619 PPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLA 4678

Query: 685  KPPTPPVMQSQSVK---PQILVPPNGVVPPPPP-------PPPPPTPGSAMAQLKP---A 731
              PTPP  Q++ V+    +    P+ +VP   P        P  P  GS   + +    +
Sbjct: 4679 ALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALS 4738

Query: 732  PCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP---PIPAPLPPQAPPK-------P 781
            P  P +P+ S P              V P T P       +P  LP     K        
Sbjct: 4739 PVIPLIPRASIP--------------VFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSV 4784

Query: 782  LVTIPAPTSTK------TVAPVVTQAAPPTPTP--PVPPAK--KQPAFPASYIPPSPPTP 831
            ++T+ A  +         VA +++   P +     P  PA+   +P    +  P      
Sbjct: 4785 MLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKG 4844

Query: 832  PVPVPPPTLPK-QQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANV 890
                 P T P   + F A  P   L     ++  +  Q  P P PP   S        NV
Sbjct: 4845 LEGKSPDTGPDWLKQFDAVLPGYTLKSQLDIL-SLLKQESPAPEPPTQHSYTY-----NV 4898

Query: 891  APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTP 950
            +      + A P  +PS  P P    P  PP   LV  P  P   P  P P P  +SP  
Sbjct: 4899 SNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSP-- 4956

Query: 951  DKSGSPGKKTSKTSSPGGKKPP 972
             +S  P  +          +PP
Sbjct: 4957 -ESARPKPRARPPEEGEDSRPP 4977



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 49/214 (22%), Positives = 75/214 (35%), Gaps = 10/214 (4%)

Query: 735  PSLPQFSAPPPPLKIHQVQ-HITQVAPPTPP--PPPPIPAPLPPQAPPKPLVTIPAPTST 791
            PS  + S PPPP     +  +  Q+   +       P P  LP Q   + L      T+ 
Sbjct: 2767 PSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAA 2826

Query: 792  KTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPP 851
             ++   ++   P TP P +   ++    P + I    P P  PVP P  P Q        
Sbjct: 2827 TSMRFAMSARFPSTPGPEL--GRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNV 2884

Query: 852  PSPLSPVPSVVK-----QIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQP 906
               L P  +        Q    +P    P  +  + L+ +  +  P   P+    P+   
Sbjct: 2885 QKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNN 2944

Query: 907  SSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPP 940
            S  P P    P  P    LV  PP  + +  P P
Sbjct: 2945 SLHPTPHTKGPTLPTGLELVNRPPSSTELGRPNP 2978



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 32/106 (30%), Positives = 40/106 (37%), Gaps = 12/106 (11%)

Query: 610  SPQPKIVTPYTAS-------QPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAP 662
            +P+P     YT +       Q S P P  P PPP P  P P  PP  P    P+   A P
Sbjct: 4885 APEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEP 4944

Query: 663  MFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGV 708
                    + L  AS    A  KP   P  + +  +P  L    GV
Sbjct: 4945 -----PVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKGV 4985



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 84/388 (21%), Positives = 123/388 (31%), Gaps = 67/388 (17%)

Query: 634  PPPPPPPPPPPPPPPL---------PSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALF 684
            PP PP   PP PPP +         PS+        A          R  +  +    L 
Sbjct: 4619 PPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLA 4678

Query: 685  KPPTPPVMQSQSVKPQI---LVPPNGVVPPPPPP-------PPPPTPGSAMAQLKPAPCA 734
              PTPP  Q++ V+ +       P+ +VP   P        P  P  GS   + +    +
Sbjct: 4679 ALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALS 4738

Query: 735  PSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK-PLVTIPAPTSTKT 793
            P +P                I + + P  P   P  A L  + P K P+ T      ++ 
Sbjct: 4739 PVIPL---------------IPRASIPVFPDTKPYGA-LGLEVPGKLPVTTWEKGKGSEV 4782

Query: 794  VAPVVTQAAPPTPTPPVPPAKKQ---PAFPASYIPPSPPTPPVPVPPPTLP-------KQ 843
               +   AA       V  A  +      P SY    P +P      P          K+
Sbjct: 4783 SVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKE 4842

Query: 844  QSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPK 903
            +    K P +     P  +KQ  +  P       ++   L       +P   P  +    
Sbjct: 4843 KGLEGKSPDTG----PDWLKQFDAVLPGYTLKSQLDILSLLK---QESPAPEPPTQHSYT 4895

Query: 904  WQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKT 963
            +  S++ V     PPP        P PPPSP+      P P + PT      P   T   
Sbjct: 4896 YNVSNLDVRQLSAPPPEE------PSPPPSPLA-----PSPASPPTEPLVELP---TEPL 4941

Query: 964  SSPGGKKPPPTPQRNSSIKSSSGAEHPE 991
            + P    P P      S +    A  PE
Sbjct: 4942 AEPPVPSPLPLASSPESARPKPRARPPE 4969



 Score = 33.9 bits (76), Expect = 1.00
 Identities = 79/357 (22%), Positives = 115/357 (32%), Gaps = 68/357 (19%)

Query: 825  PPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVP----------------SVVKQIASQ 868
            PP+PP+   P PPP++ +Q+      P   L   P                S VK +   
Sbjct: 4619 PPTPPSSLPPTPPPSV-QQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSL-DL 4676

Query: 869  FPPPPTPP-------AMESQPLKPVPANVAPQSPPAV-----------KAKPKWQPSSIP 910
                PTPP        MES      P ++ P S P                 +W+     
Sbjct: 4677 LAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRA 4736

Query: 911  VPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKK 970
            + SP  P  P  S  VFP   P        P     +      GS        S+   K 
Sbjct: 4737 L-SPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAK- 4794

Query: 971  PPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPK--PG 1028
                   N +    + AE    K P+   ++   +P      P K     P    K   G
Sbjct: 4795 -------NLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEG 4847

Query: 1029 KLNLSGVN----LPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFP---------- 1074
            K   +G +       VL    + ++  +LS   ++S    P PP+   +           
Sbjct: 4848 KSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPA--PEPPTQHSYTYNVSNLDVRQ 4905

Query: 1075 --PPPPETELPLPPIEIPAVFSGNTSPKVAVVN---PQPQQWSKMSVKKAPPPTRPK 1126
               PPPE   P P    P+  S  T P V +      +P   S + +  +P   RPK
Sbjct: 4906 LSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPK 4962



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 26/113 (23%), Positives = 48/113 (42%), Gaps = 24/113 (21%)

Query: 922  ESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSI 981
            +++L  PP PPS +P   P PPP+         +P ++  +            P+  +S 
Sbjct: 4613 KNNLSNPPTPPSSLP---PTPPPSVQQKMVNGVTPSEELGE-----------HPKDAASA 4658

Query: 982  KSSSGAEHPEPKRPSVDSLVSKFTPP----------AESGSPSKETLPPPAAP 1024
            + S  A     +  S+D L +  TPP          ++  S S +++ P ++P
Sbjct: 4659 RDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSP 4711



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 70/328 (21%), Positives = 100/328 (30%), Gaps = 62/328 (18%)

Query: 753  QHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPT---------------------ST 791
            Q +T+     PP PP    P PP +  + +V    P+                      T
Sbjct: 4609 QLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDT 4668

Query: 792  KTVAPVVTQAAPPTP----TPPVPPAKKQPA-FPASYIPPSPPTPPVPVPPPTLPKQQSF 846
              V  +   AA PTP    T  V     + +  P S +P S P   +    P  P   S 
Sbjct: 4669 SEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSG 4728

Query: 847  CAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQP 906
              +     LSPV  ++       P    P   +++P   +   V  + P     K K   
Sbjct: 4729 RWEQEDRALSPVIPLI-------PRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSE 4781

Query: 907  SSIPVPSPDFPPPPPESSLV-------FPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKK 959
             S+ +             +V          P    V  P  P      P   ++  PG K
Sbjct: 4782 VSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGK 4841

Query: 960  ------TSKTSSPGGKK------PPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFT-- 1005
                   S  + P   K      P  T +    I S    E P P+ P+  S     +  
Sbjct: 4842 EKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNL 4901

Query: 1006 --------PPAESGSPSKETLPPPAAPP 1025
                    PP E   P     P PA+PP
Sbjct: 4902 DVRQLSAPPPEEPSPPPSPLAPSPASPP 4929


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  137 bits (346), Expect = 5e-32
 Identities = 153/610 (25%), Positives = 211/610 (34%), Gaps = 125/610 (20%)

Query: 592   KARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPS 651
             K R+    R   + VP + P PK V P    +   P+PP   P  PPP  P  P   +P 
Sbjct: 10481 KVRVPEEPRVPPTKVPEVLP-PKEVVP----EKKVPVPPAKKPEAPPPKVPEAPKEVVPE 10535

Query: 652   QSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPP 711
             +  P      P                       PPT      ++  P+  VP    +PP
Sbjct: 10536 KKVPVPPPKKPEV---------------------PPTKVPEVPKAAVPEKKVPE--AIPP 10572

Query: 712   PPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPA 771
              P  PPP  P  A  ++ P    P+ P       P+K+ +           P PPP  P 
Sbjct: 10573 KPESPPPEVP-EAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPE 10631

Query: 772   PLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPS---- 827
               P + P  P V +P           V +A PP P  P P   ++P   A   PP+    
Sbjct: 10632 VPPTKVPEVPKVAVPEKK--------VPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVE 10683

Query: 828   ---PPTPPVPVPPPTLP----KQQSFCAKPPPSPLSPVPSVVKQIASQFPPP---PTPPA 877
                P  PP    PP  P    K  +  AK P  P   VP V K++  +   P   P  P 
Sbjct: 10684 EPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPE 10743

Query: 878   MESQPLKPVPANVAPQSPPAVKAKPKWQPSSIP-------------VPSP---DFPPP-- 919
                  +  VP  V P+   AV  KP+  P+ +P             VP P   + PPP  
Sbjct: 10744 APPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEV 10803

Query: 920   -------PPESSLVFPPPPPSPVPA---PPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK 969
                     PE  +   P    PVP      P  PP A P   K   P KK      P   
Sbjct: 10804 YEEPEEIAPEEEIA--PEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEA- 10860

Query: 970   KPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGK 1029
              PP  P+    I+       P P  P+      K         P K+    P  P  P K
Sbjct: 10861 PPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKV---PEKPQVPEK 10917

Query: 1030  LNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVV---------------------EFPSPP 1068
             + L+ + +PG  ++  V    P      K+ VV                     E    P
Sbjct: 10918 VELTPLKVPGGEKK--VRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKP 10975

Query: 1069  SDSDFPPPPPETELPLP-----------PIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVK 1117
             +  + PPP P  E+ +P           P ++P +      P + +  P+P+   +  VK
Sbjct: 10976 AVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEI-----KPAIPLPAPEPKPKPEAEVK 11030

Query: 1118  K-APPPTRPK 1126
                PPP  P+
Sbjct: 11031 TIKPPPVEPE 11040



 Score =  137 bits (344), Expect = 8e-32
 Identities = 148/531 (27%), Positives = 202/531 (38%), Gaps = 76/531 (14%)

Query: 626   PPLPPPPPPPPPPPPPPPPPPPP-LPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALF 684
             P  PP  P       PP  PP   +P +  P+     P  +      R+    +      
Sbjct: 10436 PKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPR------ 10489

Query: 685   KPPT--PPVMQSQSVKPQILVP-PNGVVPPPPPPPPPPTPGSAMAQLK---PAPCAPSLP 738
              PPT  P V+  + V P+  VP P    P  PPP  P  P   + + K   P P  P +P
Sbjct: 10490 VPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVP 10549

Query: 739   QFSAPPPPLKIHQVQHITQVAPPTPPPPPP---------IPAPLPPQAPP-KPLVT-IPA 787
                 P  P      + + +  PP P  PPP         +P    P APP KP VT +  
Sbjct: 10550 PTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKV 10609

Query: 788   PTSTKTVAPVVTQAAPPTPTPPVPPAK----KQPAFPASYIPPSPPTPPVPVPPPTLPKQ 843
             P + K V P      PP   P VPP K     + A P   +P + P  P   PP    + 
Sbjct: 10610 PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEP 10669

Query: 844   QSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPK 903
             +    + PP+       VV++     P P  PP +   P KPVP   A    PAV AK  
Sbjct: 10670 EEVALEEPPA------EVVEE-----PEPAAPPQVTVPPKKPVPEKKA----PAVVAK-- 10712

Query: 904   WQPSSIPVPSPDFPP---PPPESSLVFPPPPPSPVPAPPPPPPPTASP-----TPDKSGS 955
              +P   PV  P+ P    P  +  LV P  P +P PA  P  P    P      P K   
Sbjct: 10713 -KPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAP-PAKVPEVPKEVVPEKKVAVPKKPEV 10770

Query: 956   PGKKTSKT-SSPGGKKPP--PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGS 1012
             P  K  +    P  ++ P  P P+R  S       E PE   P  + +  +   P     
Sbjct: 10771 PPAKVPEVPKKPVLEEKPAVPVPERAES-PPPEVYEEPEEIAPE-EEIAPEEEKPVPVAE 10828

Query: 1013  PSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSD 1072
               +  +PPPA P +P K+ +    +P + +      K P       + V+E    P    
Sbjct: 10829 EEEPEVPPPAVPEEPKKI-IPEKKVPVIKKPEAPPPKEP-----EPEKVIE---KPKLKP 10879

Query: 1073  FPPPPPETELPLPPIE--IPAVFSGNTSPKVAV-VNPQPQQWSKMSVKKAP 1120
              PPPPP    P PP E     +F     PK  V   PQ  +  +++  K P
Sbjct: 10880 RPPPPP----PAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVP 10926



 Score =  130 bits (328), Expect = 6e-30
 Identities = 157/610 (25%), Positives = 219/610 (35%), Gaps = 113/610 (18%)

Query: 586   QLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPP--PP 643
             ++ E+ K  +     P      P  P  K+     A+ P   +P   PP P  PPP  P 
Sbjct: 10524 KVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPE 10583

Query: 644   PPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILV 703
              P   +P +  P+A                           KP   PV   ++  P+ +V
Sbjct: 10584 APKEVVPEKKVPAAPPK------------------------KPEVTPVKVPEA--PKEVV 10617

Query: 704   PPNGV-VPPPPPPPPPPT-----PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQ 757
             P   V VPPP  P  PPT     P  A+ + K     P  P+    PPP    + + +  
Sbjct: 10618 PEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPE---SPPPEVFEEPEEVAL 10674

Query: 758   VAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVP----PA 813
               PP      P PA  PPQ    P   +P   +   VA       PP   P VP    P 
Sbjct: 10675 EEPPAEVVEEPEPA-APPQVTVPPKKPVPEKKAPAVVAK--KPELPPVKVPEVPKEVVPE 10731

Query: 814   KKQPAFPASYIPPSPPTPP--VP-VPPPTLPKQQSFCAKPPPSPLSPVPSVVKQ-IASQF 869
             KK P      +P  P  PP  VP VP   +P+++    K P  P + VP V K+ +  + 
Sbjct: 10732 KKVPL----VVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEK 10787

Query: 870   PPPPTPPAMESQP--LKPVPANVAPQS----------PPAVKAKPKWQPSSIP------- 910
             P  P P   ES P  +   P  +AP+           P A + +P+  P ++P       
Sbjct: 10788 PAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKII 10847

Query: 911   -------VPSPDFPPP-PPESSLVFPPPPPSPVPAPPPPPPP--------------TASP 948
                    +  P+ PPP  PE   V   P   P P PPPP PP                  
Sbjct: 10848 PEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKK 10907

Query: 949   TPDKSGSPGK-KTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPP 1007
              P+K   P K + +    PGG+K          ++       PEPK   V   V +  P 
Sbjct: 10908 VPEKPQVPEKVELTPLKVPGGEK---------KVRKLLPERKPEPKEEVVLKSVLRKRPE 10958

Query: 1008  AESG--SPSK-ETLPPPAAPPKPGKLNLSGVNLPGVLQQG---CVSAKAPVLSGRGKDSV 1061
              E     P K E +  PA P  P    +  V +P V ++        K P +        
Sbjct: 10959 EEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPA 11018

Query: 1062  VE-FPSPPSDSDFPPPPPETELPLP---PIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVK 1117
              E  P P ++     PPP    P P   P+ +P V     +        +P+   K   K
Sbjct: 11019 PEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPK 11078

Query: 1118  KAPPPTRPKR 1127
             K P P   +R
Sbjct: 11079 KTPSPIEAER 11088



 Score =  119 bits (299), Expect = 1e-26
 Identities = 149/584 (25%), Positives = 211/584 (36%), Gaps = 102/584 (17%)

Query: 686   PPTPPVMQSQSVKPQILVPPNGVVPPPPPPPP-PPTPGSAMAQLKPAPCAPSLPQFSAPP 744
             PP  P +  + + P+   PP  VVP   PP   P  P   + + K     P  P+     
Sbjct: 10439 PPKGPEISEKIIPPK--KPPTKVVPRKEPPAKVPEVPKKIVVEEKVR--VPEEPRV---- 10490

Query: 745   PPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPP 804
             PP K+ +V    +V P    P PP   P  P  PPK       P + K V P   +   P
Sbjct: 10491 PPTKVPEVLPPKEVVPEKKVPVPPAKKPEAP--PPK------VPEAPKEVVP---EKKVP 10539

Query: 805   TPTPPVP--PAKKQPAFPASYIP-----------PSPPTPPVPVPPPTLPKQQSFCAKPP 851
              P P  P  P  K P  P + +P           P  P P VP  P  +  ++   A PP
Sbjct: 10540 VPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPP 10599

Query: 852   PSP-LSP--VPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSS 908
               P ++P  VP   K++  +   P  PP     P   VP        P V    K  P +
Sbjct: 10600 KKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVP------EVPKVAVPEKKVPEA 10653

Query: 909   IPVPSPDFPPP-----PPESSLVFPPPPPSPVPAPPPPPP---PTASPTPDKSGSPGKKT 960
             IP P P+ PPP     P E +L  PP      P P  PP    P   P P+K  +P    
Sbjct: 10654 IP-PKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKK-APAVVA 10711

Query: 961   SKTSSPGGKKP----PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKE 1016
              K   P  K P       P++   +      E P  K P V   V    P  +   P K 
Sbjct: 10712 KKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEV---VPEKKVAVPKKP 10768

Query: 1017  TLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSV--------VEFPSPP 1068
              +PP   P  P K  L     P V       +  P +    ++           E P P 
Sbjct: 10769 EVPPAKVPEVPKKPVLE--EKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPV 10826

Query: 1069  SDSDFP--PPPPETELP---LPPIEIPAVFSGNTSPKVAVVNPQPQ---QWSKMSVKKAP 1120
             ++ + P  PPP   E P   +P  ++P +      P      P+P+   +  K+  +  P
Sbjct: 10827 AEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPP---KEPEPEKVIEKPKLKPRPPP 10883

Query: 1121  PPTRPKRNDSTR-------LTQAEISEQPTMATVVP----QVPTSPKSSLSVQPGFLADL 1169
             PP  P + D          + + ++ E+P +   V     +VP   K    + P    + 
Sbjct: 10884 PPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEP 10943

Query: 1170  NRTLQRKSITRHGSLSSRMSRAEPTATMDDM------ALPPPPP 1207
                +  KS+ R      R    EP      +      A+P PPP
Sbjct: 10944 KEEVVLKSVLR-----KRPEEEEPKVEPKKLEKVKKPAVPEPPP 10982



 Score =  114 bits (285), Expect = 6e-25
 Identities = 130/544 (23%), Positives = 195/544 (35%), Gaps = 104/544 (19%)

Query: 734   APSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPP----QAPPKPLVT--IPA 787
             A  +  F  P  P K  ++    ++ PP  PP   +P   PP    + P K +V   +  
Sbjct: 10427 AEEVEVFEKPKAPPKGPEISE--KIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRV 10484

Query: 788   PTSTKTVAPVVTQAAPPTPTPP-----VPPAKKQPAFPASYIPPSP----PTPPVPVPPP 838
             P   +     V +  PP    P     VPPAKK P  P   +P +P    P   VPVPPP
Sbjct: 10485 PEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKK-PEAPPPKVPEAPKEVVPEKKVPVPPP 10543

Query: 839   TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPT--PPAMESQPLKPVPANVAPQSPP 896
               P+      K P  P + VP   K++    PP P   PP +   P + VP    P +PP
Sbjct: 10544 KKPEVPP--TKVPEVPKAAVPE--KKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPP 10599

Query: 897   AVKAKPKWQPSSIPVPSPDFPPPP-PESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGS 955
                     +P   PV  P+ P    PE  +  PPP         P  PPT  P   K   
Sbjct: 10600 K-------KPEVTPVKVPEAPKEVVPEKKVPVPPPKK-------PEVPPTKVPEVPKVAV 10645

Query: 956   PGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSK 1015
             P KK  +   P  + PPP                 EP+  +++   ++     E  +P +
Sbjct: 10646 PEKKVPEAIPPKPESPPPEV-------------FEEPEEVALEEPPAEVVEEPEPAAPPQ 10692

Query: 1016  ETLPPPAAPPKPG-------KLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDS----VVEF 1064
              T+PP    P+         K  L  V +P V ++     K P++  +  ++    V E 
Sbjct: 10693 VTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEV 10752

Query: 1065  PSP--PSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPP 1122
             P    P      P  PE    +PP ++P V      PK  V+  +P        +  PP 
Sbjct: 10753 PKEVVPEKKVAVPKKPE----VPPAKVPEV------PKKPVLEEKPAVPVPERAESPPPE 10802

Query: 1123  TRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHG 1182
                +  +     +    E+  +     + P  P  ++  +P  +       ++K      
Sbjct: 10803 VYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIP-----EKKVPVIKK 10857

Query: 1183  SLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQ 1242
               +      EP   ++   L P PP                         PPPAPPK D 
Sbjct: 10858 PEAPPPKEPEPEKVIEKPKLKPRPPP------------------------PPPAPPKEDV 10893

Query: 1243  NTKL 1246
               K+
Sbjct: 10894 KEKI 10897



 Score =  104 bits (259), Expect = 6e-22
 Identities = 114/478 (23%), Positives = 167/478 (34%), Gaps = 74/478 (15%)

Query: 585   TQLEESSKARMESMNRPYTSLVPPLSPQPKIVT-PYTASQPSPPLPPPPPPPPPPPPPPP 643
             T++ E  K  +     P      P SP P++   P   +   PP      P P  PP   
Sbjct: 10635 TKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVT 10694

Query: 644   -PPPPPLPSQSAPSAGSAAPMF--VKYSTITRLQNASQHSGALF--KPPTPPVMQSQSVK 698
              PP  P+P + AP+  +  P    VK   + +     +    +   KP  PP    +   
Sbjct: 10695 VPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEV-- 10752

Query: 699   PQILVPPNGV-VPPPPPPPP---PPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQH 754
             P+ +VP   V VP  P  PP   P  P   + + KPA     +P+ +  PPP    + + 
Sbjct: 10753 PKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAV---PVPERAESPPPEVYEEPEE 10809

Query: 755   IT---QVAPPTPPP-------PPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAP- 803
             I    ++AP    P        P +P P  P+ P K +     P   K  AP   +  P 
Sbjct: 10810 IAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPE 10869

Query: 804   -----------PTPTPPVPPAK-------KQPAFPASYIPPSPPTPP-VPVPPPTLPKQQ 844
                        P P PP PP +       +  A P   +P  P  P  V + P  +P  +
Sbjct: 10870 KVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGE 10929

Query: 845   SFCAKP-PPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPK 903
                 K  P     P   VV +   +  P    P +E + L+ V     P+ PP    +  
Sbjct: 10930 KKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEV 10989

Query: 904   WQPS-------------------SIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPP 944
               P+                   +IP+P+P+  P P        PPP    P P P   P
Sbjct: 10990 EVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVE--PEPTPIAAP 11047

Query: 945   TASPTPDKSGSPGKKTSKTSSPGG-------KKPPPTPQRNSSIKSSSGAEHPEPKRP 995
                P   K         + + P G       K P P       ++  SG E P  + P
Sbjct: 11048 VTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAP 11105



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 131/583 (22%), Positives = 203/583 (34%), Gaps = 79/583 (13%)

Query: 622   SQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVK--------------- 666
             ++P  P+P  P P  P P  P  PP  +  ++ P      P+  K               
Sbjct: 9787  TEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKV 9846

Query: 667   YSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVP-PNGVVPPPPPPPPPPTPGSAM 725
             +    R+    +    + +P     M+ + V  +  VP P   V PP   P  P      
Sbjct: 9847  FEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPE 9906

Query: 726   AQLKPAPCAPSLPQFSAPPPPLKIHQVQHI---TQVAPPTPPPPPPIP-APLPPQAPPKP 781
                        + ++        IH+ +      +V P  P   P +P  P+P +  P  
Sbjct: 9907  EVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKP-- 9964

Query: 782   LVTIPAPTSTKTVAPVVTQAAPPTPTPPVP---PAKKQPAFPASYIP--PSPPTPPVPVP 836
                +P P   K   P      P  P   VP   P K++P  P + +P  P  P P   VP
Sbjct: 9965  ---VPVP-KKKEAPPAKVPEVPKKPEEKVPVLIPKKEKP--PPAKVPEVPKKPVPEEKVP 10018

Query: 837   PPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLK--PVPANVAPQ- 893
              P   K ++  AK P  P  PVP   K++     P P P  +E+ P K   VP  + P+ 
Sbjct: 10019 VPVPKKVEAPPAKVPEVPKKPVPE--KKV-----PVPAPKKVEAPPAKVPEVPKKLIPEE 10071

Query: 894   -SPPAVKAKPKWQPSSIPVPSPDFPPP---PPESSLVFPP---PPPSPVPAPPPPPPPTA 946
               P  V  K +  P  +P      P P   P E  ++F     P    +P      P   
Sbjct: 10072 KKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEE 10131

Query: 947   SPTPDKSGSPGKKTSKTSSPGGKKPPP----TPQRNSSIKSSSGAEHPEPKRPSVDSL-- 1000
                P++     ++  +   P  ++ PP     P+    +         +PK P    +  
Sbjct: 10132 EVLPEEEEVLPEE--EEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPE 10189

Query: 1001  VSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDS 1060
             + K     +   P KE  PP   P  P K+    + LP          +  VL     + 
Sbjct: 10190 IKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILP---------KEEEVLPVEVTEE 10240

Query: 1061  VVEFPSPPSDSDFPPPPP---ETELPLPPIEIP-----AVFSGNTSPKVAVVNPQPQQWS 1112
               E   P S+ + P  PP   E E   PP  +P     AV    T     V  P  +   
Sbjct: 10241 PEE--EPISEEEIPEEPPSIEEVEEVAPP-RVPEVIKKAVPEAPTPVPKKVEAPPAKVSK 10297

Query: 1113  KMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
             K+  +K P P + K     ++ +    + P    +VP+    P
Sbjct: 10298 KIPEEKVPVPVQKKEAPPAKVPEVP-KKVPEKKVLVPKKEAVP 10339



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 126/504 (25%), Positives = 178/504 (35%), Gaps = 114/504 (22%)

Query: 753   QHITQVAPPTPPPP-PPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVP 811
             ++IT+   P P  P P  P P  P+APP  ++    P   K   P+  +  PP P  P  
Sbjct: 9784  EYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEE-KVPVPIPKKLKPPPPKVPEE 9842

Query: 812   P---------------AKKQPAFPASYIPPSP---------PTPPVPVPPPT----LPKQ 843
             P                K+Q   PA+ +P  P         P P   V PP     +PK+
Sbjct: 9843  PKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKE 9902

Query: 844   QSFCAKPPPSPLSPVPSVVKQ-------------------IASQFPPPPTPPAMESQPLK 884
                     P  ++    VV                     I  +   P  P  +   P K
Sbjct: 9903  LE------PEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRK 9956

Query: 885   PVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPP----PPPSPVPAPPP 940
             PVP    P   P  K  P       P   P+ P  P E   V  P    PPP+ VP  P 
Sbjct: 9957  PVPEEKKPVPVPKKKEAP-------PAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPK 10009

Query: 941   PPPPTAS---PTPDKSGSPGKK---TSKTSSPGGKKPPPTPQR----NSSIKSSSGAEHP 990
              P P      P P K  +P  K     K   P  K P P P++     + +        P
Sbjct: 10010 KPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIP 10069

Query: 991   EPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLP--GVL--QQGCV 1046
             E K+P+   +  K   P       +E +P P A P+  ++      +P   VL  ++  +
Sbjct: 10070 EEKKPT--PVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVL 10127

Query: 1047  SAKAPVLSGRGKDSVVEFPSPPSDSDFPPPP---PETELPLPPIEI-PAVFSGNTSPKVA 1102
               +  VL    +    E   PP + + PP     PE E  +P  E+ P V      PKV 
Sbjct: 10128 PEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEV-----KPKVP 10182

Query: 1103  VVNPQPQQWSKMSVKK--------APP---PTRPKRNDSTRL------------TQAEIS 1139
             V  P P+   K++ KK        APP   P  PK+ +  R+               E  
Sbjct: 10183 VPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPE 10242

Query: 1140  EQPTMATVVPQVPTSPKSSLSVQP 1163
             E+P     +P+ P S +    V P
Sbjct: 10243 EEPISEEEIPEEPPSIEEVEEVAP 10266



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 104/421 (24%), Positives = 157/421 (37%), Gaps = 58/421 (13%)

Query: 765  PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTP----PVPPAKKQPAFP 820
            PPP +P  LP +  P+ +  +P P   +  AP V +  P  P P    PVP  KK+PA P
Sbjct: 9284 PPPKVPE-LPEKPAPEEVAPVPIPKKVEPPAPKVPEV-PKKPVPEEKKPVPVPKKEPAAP 9341

Query: 821  ASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMES 880
                P  P  P  PVP   +P      AK   +P + VP V K + ++          ES
Sbjct: 9342 ----PKVPEVPKKPVPEEKIPVP---VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREES 9394

Query: 881  QPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPP 940
             P         P  P   K K   +   +P    + PPPP   +L   P P   V     
Sbjct: 9395 PP---------PAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAV--- 9442

Query: 941  PPPPTASPTPDKSGSPGKKT---SKTSSPGGKKPPPTPQRNSSIKSSSGAEH-----PEP 992
             P P A   P       KKT    K      K     PQR    +    AE       E 
Sbjct: 9443 -PVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEE 9501

Query: 993  KRPSVDSLVSKFTPPAESGSPSK-ETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAP 1051
            +  S+     +     E    ++ E +  P       KL++             V A+  
Sbjct: 9502 EGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKR---------VEAEPA 9552

Query: 1052 VLSGRGKDSVVEFPSPPSDSDFPPPPPETELP---LPPIEIPAVFSGNTSPKVAVVNPQ- 1107
             ++ R +  +V  P  P+  + PPP    E P   +P  ++PA       PK   V P  
Sbjct: 9553 EVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPA-----PVPKKEKVPPPK 9607

Query: 1108 -PQQWSKMSVKKAPPPTRPKRND--STRLTQ--AEISEQPTMATVVPQVPTSPKSSLSVQ 1162
             P++  K   +K  PP   K  +    ++T+   +I+++  +   V +    PK+ +  +
Sbjct: 9608 VPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEE 9667

Query: 1163 P 1163
            P
Sbjct: 9668 P 9668



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 98/450 (21%), Positives = 140/450 (31%), Gaps = 96/450 (21%)

Query: 620   TASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQS-APSAGSAAPMFVKYSTITRLQNASQ 678
             T  +  P +P   P  P  P P    P P+P +  AP A                     
Sbjct: 9938  TEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPA--------------------- 9976

Query: 679   HSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLP 738
                       P V +    K  +L+P     PP   P  P  P        P P     P
Sbjct: 9977  --------KVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAP 10028

Query: 739   QFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVV 798
                 P  P K    + +   AP     PP     +P +  P+     P P   +   P V
Sbjct: 10029 PAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKV 10088

Query: 799   TQAAPPTPTPPVPPAKKQPAFPASYIPPS------------------------------- 827
              +   P P P   P +++  F    +P                                 
Sbjct: 10089 PKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIP 10148

Query: 828   PPTPPVPVPPPTLPKQQSFC--------AKPPPSPLSPVPSVVKQIASQFPPPP----TP 875
             P    VP     +P+++ F          KP     +PVP + K++  +    P     P
Sbjct: 10149 PEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAP 10208

Query: 876   PAMESQPLKPVPAN--VAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPP---ESSLVFPPP 930
             PA   +  K V     + P+    +  +   +P   P+   + P  PP   E   V PP 
Sbjct: 10209 PAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPR 10268

Query: 931   PPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHP 990
              P  +    P  P   +P P K  +P  K SK   P  K P P  ++          E P
Sbjct: 10269 VPEVIKKAVPEAP---TPVPKKVEAPPAKVSK-KIPEEKVPVPVQKK----------EAP 10314

Query: 991   EPKRPSVDSLVSKFTPPAESGSPSKETLPP 1020
               K P     V K  P  +   P KE +PP
Sbjct: 10315 PAKVPE----VPKKVPEKKVLVPKKEAVPP 10340



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 94/403 (23%), Positives = 128/403 (31%), Gaps = 103/403 (25%)

Query: 763  PPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPAS 822
            P   P   AP PP+   KP++     TS +     V     P  +  + P K     P  
Sbjct: 9166 PAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRT-PVQ 9224

Query: 823  YIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLS-PVPSVVKQIASQ----------FPP 871
                    P V      + +++ F A      +S  VP V K+I ++            P
Sbjct: 9225 EEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEP 9284

Query: 872  PPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPP 931
            PP  P +   P KP P  VAP                +P+P    PP P    +   P P
Sbjct: 9285 PPKVPEL---PEKPAPEEVAP----------------VPIPKKVEPPAPKVPEVPKKPVP 9325

Query: 932  ----PSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGA 987
                P PVP   P  PP     P K                    P P+    +  +   
Sbjct: 9326 EEKKPVPVPKKEPAAPPKVPEVPKK--------------------PVPEEKIPVPVAKKK 9365

Query: 988  EHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVS 1047
            E P  K P V   V   T    +    +E  PPPA P  P K                  
Sbjct: 9366 EAPPAKVPEVQKGV--VTEEKITIVTQREESPPPAVPEIPKK------------------ 9405

Query: 1048 AKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQ 1107
                      K      P P  + + PPPP    LP  P+           P+  V  P 
Sbjct: 9406 ----------KVPEERKPVPRKEEEVPPPPKVPALPKKPV-----------PEEKVAVPV 9444

Query: 1108 PQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQ 1150
            P        KKAPPP R + +  T + +     +  ++  VPQ
Sbjct: 9445 P------VAKKAPPP-RAEVSKKTVVEEKRFVAEEKLSFAVPQ 9480



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 102/460 (22%), Positives = 154/460 (33%), Gaps = 99/460 (21%)

Query: 609  LSPQPKIVTPYTASQPSP----PLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMF 664
            + P PK+  P    +P+P    P+P P    PP P  P  P  P+P +  P         
Sbjct: 9282 VEPPPKV--PELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVP------- 9332

Query: 665  VKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA 724
                 + + + A+        PP  P +  + V  + +  P       PP   P      
Sbjct: 9333 -----VPKKEPAA--------PPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGV 9379

Query: 725  MAQLK----------PAPCAPSLPQFSAP----PPPLKIHQVQHITQVAPPTPPPPPPIP 770
            + + K          P P  P +P+   P    P P K  +V           PPPP +P
Sbjct: 9380 VTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEV-----------PPPPKVP 9428

Query: 771  APLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPS--- 827
            A LP +  P+  V +P P + K         APP   P    +KK       ++      
Sbjct: 9429 A-LPKKPVPEEKVAVPVPVAKK---------APP---PRAEVSKKTVVEEKRFVAEEKLS 9475

Query: 828  ---PPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQ-------IASQFPPPPTPPA 877
               P    V     +  ++ S+  +     +S      ++          +    P    
Sbjct: 9476 FAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYV 9535

Query: 878  ME------SQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPP 931
            +E      S+ ++  PA V  +    +  KPK  P+ I  P P   P  P+  +V     
Sbjct: 9536 VEEKLHIISKRVEAEPAEVTERQEKKIVLKPK-IPAKIEEPPPAKVPEAPK-KIVPEKKV 9593

Query: 932  PSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSS------- 984
            P+PVP     PPP     P K     K   K        P    +R+  I          
Sbjct: 9594 PAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAV 9653

Query: 985  SGAEHP-------EPKRPSVDSLVSKFTPPAESGSPSKET 1017
            +  E P       EPKR   +  V K  P  E   P+K T
Sbjct: 9654 TKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVT 9693



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 109/487 (22%), Positives = 171/487 (35%), Gaps = 91/487 (18%)

Query: 727   QLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ---APPKPLV 783
             Q K     P +P     PPP K+ +       AP    P   +PAP+P +    PPK   
Sbjct: 9558  QEKKIVLKPKIPAKIEEPPPAKVPE-------APKKIVPEKKVPAPVPKKEKVPPPKVPE 9610

Query: 784   TIPAPTSTKTVAPVVTQAAPPTPTP----PVPPAKKQPAFPASYIPPSPPTPPVPVPPP- 838
                 P   K V P V +   P P       +   +++    A     +PP   VP  P  
Sbjct: 9611  EPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKR 9670

Query: 839   TLPKQQSFCAKP--PPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVP-------AN 889
              +P+++    KP     P + V    K++  +       P  E QP+K V        A 
Sbjct: 9671  AVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAY 9730

Query: 890   VAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPP------------------ESSLVFPPPP 931
                +   +V+ + +++         +F    P                  E    +   P
Sbjct: 9731  TLEEEAVSVQREEEYEEYE-EYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEP 9789

Query: 932   PSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPE 991
               P+P  P P      P P K  +P  K  K + P  K P P P++          + P 
Sbjct: 9790  EKPIPVKPVP----EEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKK---------LKPPP 9836

Query: 992   PKRPSVDSLVSKFTPPAESGSPSKETLPPPAAP--------------PKPGKLNLSGVNL 1037
             PK P     V +           KE +  PAA               P P K     V +
Sbjct: 9837  PKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRV 9896

Query: 1038  PGV---LQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFS 1094
             P V   L+   V+ +  V++   ++ +VE        +      E  +P+ P+++P V  
Sbjct: 9897  PEVPKELEPEEVAFEEEVVT-HVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEV-- 9953

Query: 1095  GNTSPKVAVVNPQPQQWSKMSV---KKAPP---PTRPKRNDSTRLTQAEISEQPTMATVV 1148
                 P+     P P++   + V   K+APP   P  PK+ +          E+P  A  V
Sbjct: 9954  ----PR----KPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAK-V 10004

Query: 1149  PQVPTSP 1155
             P+VP  P
Sbjct: 10005 PEVPKKP 10011



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/156 (24%), Positives = 55/156 (35%), Gaps = 9/156 (5%)

Query: 601  PYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAP----- 655
            P    V P +P+   V      +   P+P P   P  PP  P  P  P+P +  P     
Sbjct: 9304 PIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAK 9363

Query: 656  --SAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPP 713
               A  A    V+   +T  +           PP  P +  + V  +    P      PP
Sbjct: 9364 KKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPP 9423

Query: 714  PPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKI 749
            PP  P  P   + + K A   P   +  APPP  ++
Sbjct: 9424 PPKVPALPKKPVPEEKVAVPVPVAKK--APPPRAEV 9457



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 39/146 (26%), Positives = 57/146 (39%), Gaps = 27/146 (18%)

Query: 855 LSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSP 914
           ++ V  V+   A Q  P  TPP +  +P    P      +PP++ AK +      P P  
Sbjct: 234 IATVEMVIDGAAGQQLPHKTPPRIPPKPKSRSP------TPPSIAAKAQLARQQSPSP-- 285

Query: 915 DFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSP---------GKKTSKTSS 965
                     +   P P   V AP P P  + SP    S SP          +KT  ++ 
Sbjct: 286 ----------IRHSPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTV 335

Query: 966 PGGKKPPPTPQRNSSIKSSSGAEHPE 991
             G + PP  ++   + SSS AE  E
Sbjct: 336 ATGPEVPPPWKQEGYVASSSEAEMRE 361



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 74/348 (21%), Positives = 102/348 (29%), Gaps = 91/348 (26%)

Query: 820  PASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPL--SPVPSVVKQIASQFPPPPTPPA 877
            PA       P PP  +  P + K +    +     +  + VP V K+I  Q   P   P 
Sbjct: 9166 PAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQ--KPSRTPV 9223

Query: 878  MESQPLKPVPA----NVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPE------SSLVF 927
             E      VPA     +         A    +  S+ VP         E      S  V 
Sbjct: 9224 QEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVE 9283

Query: 928  PPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGA 987
            PPP    +P  P P      P P K   P  K  +      KKP                
Sbjct: 9284 PPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVP----KKPV--------------- 9324

Query: 988  EHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVS 1047
              PE K+P                 P KE    PAAPPK                     
Sbjct: 9325 --PEEKKPVP--------------VPKKE----PAAPPK--------------------- 9343

Query: 1048 AKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQ 1107
                         V E P  P   +  P P   +   PP ++P V  G  + +   +  Q
Sbjct: 9344 -------------VPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQ 9390

Query: 1108 PQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155
             ++    +V + P    P+        + E+   P     VP +P  P
Sbjct: 9391 REESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPK----VPALPKKP 9434



 Score = 38.9 bits (89), Expect = 0.031
 Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 10/111 (9%)

Query: 722 GSAMAQL--KPAPCAPSLPQFSAPPPPLKIHQVQHITQVAP-PTPPPPPPI-------PA 771
           G+A  QL  K  P  P  P+  +P PP    + Q   Q +P P    P P+       P+
Sbjct: 243 GAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPS 302

Query: 772 PLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPAS 822
           P+   +P   + T P  +    +    TQA+     P VPP  KQ  + AS
Sbjct: 303 PVRSVSPAARISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQEGYVAS 353



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 29/104 (27%), Positives = 41/104 (39%), Gaps = 10/104 (9%)

Query: 727  QLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ-APPKPLVTI 785
            +LKP    P +P    P P + I  V    +  PP   PP P+  P P +  PP   + +
Sbjct: 8931 ELKP----PDIPDSRVPIPTMPIRAVP--PEEIPPVVAPPIPLLLPTPEEKKPPPKRIEV 8984

Query: 786  PAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPP 829
                  K    VV +    TP   +    K+P  P + IP   P
Sbjct: 8985 TKKAVKKDAKKVVAKPKEMTPREEI---VKKPPPPTTLIPAKAP 9025



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 29/103 (28%), Positives = 38/103 (36%), Gaps = 28/103 (27%)

Query: 863  KQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPP--- 919
            K+I  +  PP  P +    P  P+ A V P+  P V A P   P  +P P    PPP   
Sbjct: 8926 KEIKLELKPPDIPDSRVPIPTMPIRA-VPPEEIPPVVAPP--IPLLLPTPEEKKPPPKRI 8982

Query: 920  ----------------------PPESSLVFPPPPPSPVPAPPP 940
                                  P E  +  PPPP + +PA  P
Sbjct: 8983 EVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAP 9025



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 12/98 (12%)

Query: 808  PPVPPAKKQ-PAFPASYIPPS--PP--TPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVV 862
            P +P ++   P  P   +PP   PP   PP+P+  PT P+++    KPPP  +      V
Sbjct: 8935 PDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPT-PEEK----KPPPKRIEVTKKAV 8989

Query: 863  KQIASQF--PPPPTPPAMESQPLKPVPANVAPQSPPAV 898
            K+ A +    P    P  E     P P  + P   P +
Sbjct: 8990 KKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEI 9027



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 28/113 (24%), Positives = 42/113 (37%), Gaps = 13/113 (11%)

Query: 769 IPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSP 828
           +P   PP+ PPKP    P P S    A +  Q +P        P +  P+ P  ++    
Sbjct: 249 LPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQSP-------SPIRHSPS-PVRHVRAPT 300

Query: 829 PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQ 881
           P+P   V P            P  S  SP+     Q ++    P  PP  + +
Sbjct: 301 PSPVRSVSPAA-----RISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQE 348



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 14/88 (15%)

Query: 796  PVVTQAAPPTPTPPVP--PAKKQPAFPASYIPPSPPTPPVPVPPP-------TLPKQQSF 846
            P +  +  P PT P+   P ++ P   A  IP   PTP    PPP          K+ + 
Sbjct: 8935 PDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAK 8994

Query: 847  CAKPPPSPLSPVPSVVKQIASQFPPPPT 874
                 P  ++P   +VK+     PPPPT
Sbjct: 8995 KVVAKPKEMTPREEIVKK-----PPPPT 9017



 Score = 33.9 bits (76), Expect = 1.00
 Identities = 27/106 (25%), Positives = 40/106 (37%), Gaps = 23/106 (21%)

Query: 917  PPPPPESSLVFPPPP-----PSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP 971
            PP  P+S +  P  P     P  +P    PP P   PTP++                KKP
Sbjct: 8934 PPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTPEE----------------KKP 8977

Query: 972  PP--TPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSK 1015
            PP        ++K  +     +PK  +    + K  PP  +  P+K
Sbjct: 8978 PPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAK 9023



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 21/64 (32%), Positives = 26/64 (40%), Gaps = 5/64 (7%)

Query: 963   TSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPA 1022
             TS P  K P P  +   ++KS    + PEP  P   S       P E     K    P +
Sbjct: 32661 TSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTE-----KVQHLPVS 32715

Query: 1023  APPK 1026
             APPK
Sbjct: 32716 APPK 32719



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 21/64 (32%), Positives = 32/64 (50%), Gaps = 9/64 (14%)

Query: 751   QVQHITQVAPPTPP----PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTP 806
             Q   +T+ A  +PP    P P + +P   ++P +  V  P P+  K V+P  T+   PTP
Sbjct: 32651 QKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKR--VKSPEPSHPKAVSPTETK---PTP 32705

Query: 807   TPPV 810
             T  V
Sbjct: 32706 TEKV 32709



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 39/194 (20%), Positives = 72/194 (37%), Gaps = 16/194 (8%)

Query: 521 ESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGH--VRSQSIVSSVFS 578
           +S+ D+       + S   + + PE    +S  + + V          V+ +  V +  +
Sbjct: 145 QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKT 204

Query: 579 EAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPP 638
           +      Q+ ES + R+E     +      ++    ++      Q    LP   PP  PP
Sbjct: 205 KTIVSTAQISESRQTRIEKKIEAHFD-ARSIATVEMVIDGAAGQQ----LPHKTPPRIPP 259

Query: 639 PPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVK 698
            P    P PP  +  A  A   +P  +++S      +  +H     + PTP  ++S S  
Sbjct: 260 KPKSRSPTPPSIAAKAQLARQQSPSPIRHS-----PSPVRH----VRAPTPSPVRSVSPA 310

Query: 699 PQILVPPNGVVPPP 712
            +I   P   V  P
Sbjct: 311 ARISTSPIRSVRSP 324


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  137 bits (345), Expect = 6e-32
 Identities = 131/449 (29%), Positives = 154/449 (34%), Gaps = 108/449 (24%)

Query: 599  NRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPP---PPPPPPPPLPSQSAP 655
            N+P     PP  PQ     P   +QP  P PPP  P  PPP     P  PPPP   Q  P
Sbjct: 45   NKPQGPPSPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP 102

Query: 656  SAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP 715
              G  +                       + P  P  + Q   PQ    P G  PPP  P
Sbjct: 103  PQGDKS-----------------------RSPRSPPGKPQGPPPQGGNQPQGPPPPPGKP 139

Query: 716  PPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPP 775
              PP  G    Q  P P  P        PPP   ++ +  +  +PP  P  PP      P
Sbjct: 140  QGPPPQGGNKPQGPPPPGKPQ------GPPPQGDNKSR--SSRSPPGKPQGPPPQGGNQP 191

Query: 776  QAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPV 835
            Q PP P                     P  P  P P    +P        P PP  P   
Sbjct: 192  QGPPPP---------------------PGKPQGPPPQGGNKPQ------GPPPPGKPQGP 224

Query: 836  PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPP------TPPAMESQPLKPVPAN 889
            PP    K QS    PP  P  P P    Q   Q PPPP       PP   ++P  P P  
Sbjct: 225  PPQGDNKSQS-ARSPPGKPQGPPPQGGNQ--PQGPPPPPGKPQGPPPQGGNKPQGPPPPG 281

Query: 890  VAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPP--------P 941
              PQ PP  +   K + S  P   P  PPP   +    PPPPP     PPP        P
Sbjct: 282  -KPQGPPP-QGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGP 339

Query: 942  PPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLV 1001
            PPP     P   G  G K+    SP GK   P  Q  ++           P+ P      
Sbjct: 340  PPPGKPQGPPPQG--GSKSRSARSPPGKPQGPPQQEGNN-----------PQGP------ 380

Query: 1002 SKFTPPAESGSPSKETLPP---PAAPPKP 1027
                PP   G+P +   PP   P  PP+P
Sbjct: 381  ----PPPAGGNPQQPQAPPAGQPQGPPRP 405



 Score =  124 bits (310), Expect = 7e-28
 Identities = 125/431 (29%), Positives = 148/431 (34%), Gaps = 78/431 (18%)

Query: 694  SQSVKPQILV------PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747
            SQ   P ++       PP G   P  PP PP  P        P P   + PQ   PPPP 
Sbjct: 24   SQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQG------PPPQGGNQPQG--PPPP- 74

Query: 748  KIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPT 807
                        P  P  PPP     P   PP      P P   K+ +P      P  P 
Sbjct: 75   ------------PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPP 122

Query: 808  ---------PPVPPAKKQ-PAFPASYIPPSPPTPPVPV-PPPTLPKQQSFCAKPPPSPLS 856
                     PP PP K Q P       P  PP P  P  PPP    +      PP  P  
Sbjct: 123  PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQG 182

Query: 857  PVPSVVKQIASQFPPPP------TPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIP 910
            P P    Q   Q PPPP       PP   ++P  P P    PQ PP  +   K Q +  P
Sbjct: 183  PPPQGGNQ--PQGPPPPPGKPQGPPPQGGNKPQGPPPPG-KPQGPPP-QGDNKSQSARSP 238

Query: 911  VPSPDFPPPPPESSLVFPPPPPSPVPAPPP--------PPPPTASPTPDKSGSPGKKTSK 962
               P  PPP   +    PPPPP     PPP        PPPP     P   G  G K+  
Sbjct: 239  PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQG--GSKSRS 296

Query: 963  TSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPP-- 1020
            + SP GK   P PQ  +  +       P P +P          PP + G+  +   PP  
Sbjct: 297  SRSPPGKPQGPPPQGGNQPQGPP----PPPGKPQ--------GPPPQGGNKPQGPPPPGK 344

Query: 1021 PAAPPKPGKLNLSGVNLP-----GVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPP 1075
            P  PP  G         P     G  QQ   + + P     G     + P P      PP
Sbjct: 345  PQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAP-PAGQPQGPP 403

Query: 1076 PPPETELPLPP 1086
             PP+   P  P
Sbjct: 404  RPPQGGRPSRP 414



 Score =  114 bits (286), Expect = 4e-25
 Identities = 112/364 (30%), Positives = 133/364 (36%), Gaps = 66/364 (18%)

Query: 607 PPLSPQ-PKIVTPYTASQPSPPLPPPPPPPP-------PPPPP-----PPP--------P 645
           PP  PQ P      + S  SPP  P  PPP        PPPPP     PPP        P
Sbjct: 94  PPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGP 153

Query: 646 PPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPP 705
           PPP   Q  P  G       + S   + Q      G   + P PP  + Q   PQ    P
Sbjct: 154 PPPGKPQGPPPQGDNKSRSSR-SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKP 212

Query: 706 NGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPP 765
            G  PPP  P  PP  G   +Q   +P  P  PQ    PPP   +Q        P  PPP
Sbjct: 213 QG-PPPPGKPQGPPPQGDNKSQSARSP--PGKPQ---GPPPQGGNQ--------PQGPPP 258

Query: 766 PPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIP 825
           PP  P   PPQ   KP                  Q  PP   P  PP +      +S  P
Sbjct: 259 PPGKPQGPPPQGGNKP------------------QGPPPPGKPQGPPPQGGSKSRSSRSP 300

Query: 826 PSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKP 885
           P  P      PPP    Q      PP  P  P P    +   Q PPPP  P  +  P + 
Sbjct: 301 PGKPQG----PPPQGGNQPQGPPPPPGKPQGPPPQGGNK--PQGPPPPGKP--QGPPPQG 352

Query: 886 VPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPT 945
              + + +SPP     P  Q  +    +P  PPPP   +   P  PP+  P  PP PP  
Sbjct: 353 GSKSRSARSPPGKPQGPPQQEGN----NPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQG 408

Query: 946 ASPT 949
             P+
Sbjct: 409 GRPS 412



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 80/308 (25%), Positives = 100/308 (32%), Gaps = 45/308 (14%)

Query: 871  PPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFP--PPPPESSLVFP 928
            P   PP   ++P  P      PQ PP        QP   P P P  P  PPP   +    
Sbjct: 36   PQGAPPQGGNKPQGPPSPPGKPQGPPPQGGN---QPQG-PPPPPGKPQGPPPQGGNKPQG 91

Query: 929  PPPPSPVPAPPPPPPPTASP--TPDKSGSP----GKKTSKTSSPGGKKPPPTPQRNSSIK 982
            PPPP     PPP    + SP   P K   P    G +      P GK   P PQ  +  +
Sbjct: 92   PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 151

Query: 983  SSSGAEHPEPKRPSVD--SLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGV 1040
                   P+   P  D  S  S+  P    G P +    P   PP PGK         G 
Sbjct: 152  GPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ-------GP 204

Query: 1041 LQQGCVSAKAPVLSGR-------GKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVF 1093
              QG    + P   G+       G +      SPP     PPP    +   PP       
Sbjct: 205  PPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPP------- 257

Query: 1094 SGNTSPKVAVVNPQPQQWSK------MSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATV 1147
                 P      P PQ  +K          + PPP    ++ S+R    +    P     
Sbjct: 258  ----PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGN 313

Query: 1148 VPQVPTSP 1155
             PQ P  P
Sbjct: 314  QPQGPPPP 321



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 87/363 (23%), Positives = 112/363 (30%), Gaps = 59/363 (16%)

Query: 893  QSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDK 952
            +SP  +   P+  P       P  PP PP      PPP     P  PPPPP      P +
Sbjct: 27   ESPSLIAGNPQGAPPQ-GGNKPQGPPSPPGKPQG-PPPQGGNQPQGPPPPPGKPQGPPPQ 84

Query: 953  SGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGS 1012
             G+          P G  PP  PQ        S +    P +P          PP + G+
Sbjct: 85   GGN---------KPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQ--------GPPPQGGN 127

Query: 1013 PSKETLPPPA---APPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPP- 1068
              +   PPP     PP  G     G   PG  Q           S R      + P P  
Sbjct: 128  QPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQG 187

Query: 1069 -SDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKR 1127
             +    PPPPP      PP        G   P+      +PQ          PPP    +
Sbjct: 188  GNQPQGPPPPPGKPQGPPP-------QGGNKPQGPPPPGKPQ---------GPPPQGDNK 231

Query: 1128 NDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNR----TLQRKSITRHGS 1183
            + S R    +    P      PQ P  P       P    +  +      + +     G 
Sbjct: 232  SQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGG 291

Query: 1184 LSSRMSRAEPTATM-------DDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPA 1236
              SR SR+ P           +    PPPPP     Q     GG+   G       PPP 
Sbjct: 292  SKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPG--KPQGPPPQGGNKPQG------PPPPG 343

Query: 1237 PPK 1239
             P+
Sbjct: 344  KPQ 346


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score =  136 bits (343), Expect = 1e-31
 Identities = 143/513 (27%), Positives = 195/513 (38%), Gaps = 61/513 (11%)

Query: 530  SSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEE 589
            +SS +KS         S +  ++++ S  + TQ      S S      S++  R    E 
Sbjct: 86   ASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDS--RSVNDEG 143

Query: 590  SSKAR-MESMNRPYTSLVPPLSPQPKIVTPYTASQPS-----PPLPPPPPPPPPPPPPPP 643
            SS  + ++  NR  +  +P  SPQ       +++Q       PP    P    P P   P
Sbjct: 144  SSDPKDIDQDNRSTSPSIP--SPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAP 201

Query: 644  PPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILV 703
            P  P LP+     + +A P      + T  Q  +Q        P   + Q+ ++ PQ   
Sbjct: 202  PGTPQLPTPGPTPSATAVP---PQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQR-- 256

Query: 704  PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTP 763
                  PP P PPP P+P   +  L  +   PS P  + PP   +     H  Q  P   
Sbjct: 257  ------PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ 310

Query: 764  PPPPPIPAPLPPQAPP--KPLVTIPAPTSTKT-----VAPVVTQAAPPTPTPPVPPAKKQ 816
             P PP P  LPPQA     PL T PA     T      +    Q+  P    P+PPA   
Sbjct: 311  HPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPL- 369

Query: 817  PAFPASYIPPSPPTPPVPVP-----PPTLPKQQSFCAK---PPPSPLSPVPSVVKQIASQ 868
             A P    PP+ P P +P P     PP L     F      PPP  L P+ S+       
Sbjct: 370  -AMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 428

Query: 869  FPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP 928
              PPP     +SQPL        P SP    A+P     S  +P P    PP     V P
Sbjct: 429  AHPPPLQLMPQSQPL--------PSSP----AQPPGLTQSQNLPPPPASHPPTGLHQVAP 476

Query: 929  PPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKS-SSGA 987
             PP +  P  P  PPP   PT   + +P       + PG    PP     +S  S + G+
Sbjct: 477  QPPFAQHPFVPGGPPPITPPTCPSTSTP------PAGPGTSAQPPCSGAAASGGSIAGGS 530

Query: 988  EHPEP----KRPSVDSLVSKFTPPAESGSPSKE 1016
              P P    K  ++D      +PP    SPS E
Sbjct: 531  SCPLPTVQIKEEALDDAEEPESPPPPPRSPSPE 563



 Score =  115 bits (288), Expect = 3e-25
 Identities = 129/462 (27%), Positives = 169/462 (36%), Gaps = 80/462 (17%)

Query: 538 SSSSSIPESQSNHSNQSDSG---VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEES---- 590
           S+S SIP  Q N S+   S    +   QP   +++ + V+   S A     QL       
Sbjct: 156 STSPSIPSPQDNESDSDSSAQQQMLQAQPPA-LQAPTGVTPAPSSAPPGTPQLPTPGPTP 214

Query: 591 SKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLP 650
           S   +     P  S  P     P    P+T  Q +P L P  PP P PPP P P PP   
Sbjct: 215 SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP--- 271

Query: 651 SQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVP 710
               P  GSA              +A  H+        PP   S    P +  P      
Sbjct: 272 --LQPLTGSAGQ-----------PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPG----- 313

Query: 711 PPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVA-PPTPPPPPPI 769
           PP P   PP      A L  +P A      + P   L++   Q   Q   PP   P PP 
Sbjct: 314 PPQPFGLPPQASQGQAPLGTSPAA------AYPHTSLQLPASQSALQSQQPPREQPLPPA 367

Query: 770 PAPLPPQAPPK--PLVTIPAPTSTKTVAPVVTQAAPPT-----PTPPV-----------P 811
           P  +P   PP   P+  +PAP + K   P ++  +P +     P PP            P
Sbjct: 368 PLAMPHIKPPPTTPIPQLPAPQAHKH-PPHLSGPSPFSMNANLPPPPALKPLSSLSTHHP 426

Query: 812 PAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ--- 868
           P+   P  P   +P S P P  P  PP L + Q+     PP P S  P+ + Q+A Q   
Sbjct: 427 PSAHPP--PLQLMPQSQPLPSSPAQPPGLTQSQNL----PPPPASHPPTGLHQVAPQPPF 480

Query: 869 --------FPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQ---PSSIPVPSPDFP 917
                    PPP TPP   S    P     + Q P +  A         SS P+P+    
Sbjct: 481 AQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIK 540

Query: 918 PPPPESSLVFPPPPPSPVPAP-PPPPPPTASPTPDKSGSPGK 958
               E +L     P SP P P  P P PT   TP  +    +
Sbjct: 541 ----EEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSAR 578



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 122/437 (27%), Positives = 161/437 (36%), Gaps = 65/437 (14%)

Query: 734  APSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP-KPLVTIPAPTSTK 792
            +PS+P              Q + Q  PP    P  +  P P  APP  P +  P PT + 
Sbjct: 158  SPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGV-TPAPSSAPPGTPQLPTPGPTPSA 216

Query: 793  TV-----APVVTQAA--PPTPTPPVPPAKKQPAFPASYI--PPSPPTPPVPVPPPTL--- 840
            T      +P  +QA   P  PT PVP    Q A PA +   PPSP  PP P P P L   
Sbjct: 217  TAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQA-PALHPQRPPSPHPPPHPSPHPPLQPL 275

Query: 841  ------PKQQSFCAKPPPSPLSPVP-SVVKQIASQFPPPPTP---PAMESQPLKPVPANV 890
                  P   S    P      P P S+      Q P PP P   P   SQ   P+  + 
Sbjct: 276  TGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSP 335

Query: 891  APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP---PPPPSPVPAPPPP-----P 942
            A   P      P  Q S++    P    P P + L  P   PPP +P+P  P P     P
Sbjct: 336  AAAYPHTSLQLPASQ-SALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHP 394

Query: 943  PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSG-AEHPEPKRPSVDSLV 1001
            P  + P+P             S      PPP  +  SS+ +    + HP P +    S  
Sbjct: 395  PHLSGPSP------------FSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQP 442

Query: 1002 SKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSV 1061
               +P    G    + LPPP A   P  L+      P         A+ P + G G   +
Sbjct: 443  LPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPP--------FAQHPFVPG-GPPPI 493

Query: 1062 VEFPSPPSDSDFPPPPPETELPLPPIEIPAV----FSGNTSPKVAVVNPQPQQWSKMSVK 1117
               P+ PS S  PP  P T    PP    A      +G +S  +  V  + +        
Sbjct: 494  TP-PTCPSTST-PPAGPGTSAQ-PPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEP 550

Query: 1118 KAPPPTRPKRNDSTRLT 1134
            ++PPP  P R+ S   T
Sbjct: 551  ESPPP--PPRSPSPEPT 565



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 97/390 (24%), Positives = 132/390 (33%), Gaps = 97/390 (24%)

Query: 830  TPPVPVPPP------TLPKQQSFCAKPP----PSPLSPVPSVVKQIASQFPPP-PTPPAM 878
            +P +P P        +  +QQ   A+PP    P+ ++P PS       Q P P PTP A 
Sbjct: 158  SPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSAT 217

Query: 879  ESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAP 938
               P     A+ AP  P A  A         PVP       P     + P  PPSP P P
Sbjct: 218  AVPPQGSPTASQAPNQPQAPTA---------PVPHTHIQQAPA----LHPQRPPSPHPPP 264

Query: 939  PPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVD 998
             P P P   P    +G P    S    P   + PP P    S+++    +HP P +P   
Sbjct: 265  HPSPHPPLQPLTGSAGQPSAP-SHAQPPLHGQGPPGPH---SLQAGPLLQHPGPPQPF-- 318

Query: 999  SLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGK 1058
                   P A  G     T P  A P        + + LP    Q  + ++ P       
Sbjct: 319  ----GLPPQASQGQAPLGTSPAAAYPH-------TSLQLPA--SQSALQSQQPPR----- 360

Query: 1059 DSVVEFPSPPSDSDFP--PPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSV 1116
                E P PP+    P   PPP T +P    ++PA  +    P ++  +P       M+ 
Sbjct: 361  ----EQPLPPAPLAMPHIKPPPTTPIP----QLPAPQAHKHPPHLSGPSP-----FSMNA 407

Query: 1117 KKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRK 1176
               PPP       S+  T    S  P    ++PQ    P S                   
Sbjct: 408  NLPPPPALKPL--SSLSTHHPPSAHPPPLQLMPQSQPLPSSP------------------ 447

Query: 1177 SITRHGSLSSRMSRAEPTATMDDMALPPPP 1206
                          A+P        LPPPP
Sbjct: 448  --------------AQPPGLTQSQNLPPPP 463


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  136 bits (343), Expect = 1e-31
 Identities = 143/513 (27%), Positives = 195/513 (38%), Gaps = 61/513 (11%)

Query: 530  SSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEE 589
            +SS +KS         S +  ++++ S  + TQ      S S      S++  R    E 
Sbjct: 640  ASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDS--RSVNDEG 697

Query: 590  SSKAR-MESMNRPYTSLVPPLSPQPKIVTPYTASQPS-----PPLPPPPPPPPPPPPPPP 643
            SS  + ++  NR  +  +P  SPQ       +++Q       PP    P    P P   P
Sbjct: 698  SSDPKDIDQDNRSTSPSIP--SPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAP 755

Query: 644  PPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILV 703
            P  P LP+     + +A P      + T  Q  +Q        P   + Q+ ++ PQ   
Sbjct: 756  PGTPQLPTPGPTPSATAVP---PQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQR-- 810

Query: 704  PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTP 763
                  PP P PPP P+P   +  L  +   PS P  + PP   +     H  Q  P   
Sbjct: 811  ------PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ 864

Query: 764  PPPPPIPAPLPPQAPP--KPLVTIPAPTSTKT-----VAPVVTQAAPPTPTPPVPPAKKQ 816
             P PP P  LPPQA     PL T PA     T      +    Q+  P    P+PPA   
Sbjct: 865  HPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPL- 923

Query: 817  PAFPASYIPPSPPTPPVPVP-----PPTLPKQQSFCAK---PPPSPLSPVPSVVKQIASQ 868
             A P    PP+ P P +P P     PP L     F      PPP  L P+ S+       
Sbjct: 924  -AMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 869  FPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP 928
              PPP     +SQPL        P SP    A+P     S  +P P    PP     V P
Sbjct: 983  AHPPPLQLMPQSQPL--------PSSP----AQPPGLTQSQNLPPPPASHPPTGLHQVAP 1030

Query: 929  PPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKS-SSGA 987
             PP +  P  P  PPP   PT   + +P       + PG    PP     +S  S + G+
Sbjct: 1031 QPPFAQHPFVPGGPPPITPPTCPSTSTP------PAGPGTSAQPPCSGAAASGGSIAGGS 1084

Query: 988  EHPEP----KRPSVDSLVSKFTPPAESGSPSKE 1016
              P P    K  ++D      +PP    SPS E
Sbjct: 1085 SCPLPTVQIKEEALDDAEEPESPPPPPRSPSPE 1117



 Score =  115 bits (288), Expect = 3e-25
 Identities = 129/462 (27%), Positives = 169/462 (36%), Gaps = 80/462 (17%)

Query: 538  SSSSSIPESQSNHSNQSDSG---VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEES---- 590
            S+S SIP  Q N S+   S    +   QP   +++ + V+   S A     QL       
Sbjct: 710  STSPSIPSPQDNESDSDSSAQQQMLQAQPPA-LQAPTGVTPAPSSAPPGTPQLPTPGPTP 768

Query: 591  SKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLP 650
            S   +     P  S  P     P    P+T  Q +P L P  PP P PPP P P PP   
Sbjct: 769  SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP--- 825

Query: 651  SQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVP 710
                P  GSA              +A  H+        PP   S    P +  P      
Sbjct: 826  --LQPLTGSAGQ-----------PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPG----- 867

Query: 711  PPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVA-PPTPPPPPPI 769
            PP P   PP      A L  +P A      + P   L++   Q   Q   PP   P PP 
Sbjct: 868  PPQPFGLPPQASQGQAPLGTSPAA------AYPHTSLQLPASQSALQSQQPPREQPLPPA 921

Query: 770  PAPLPPQAPPK--PLVTIPAPTSTKTVAPVVTQAAPPT-----PTPPV-----------P 811
            P  +P   PP   P+  +PAP + K   P ++  +P +     P PP            P
Sbjct: 922  PLAMPHIKPPPTTPIPQLPAPQAHKH-PPHLSGPSPFSMNANLPPPPALKPLSSLSTHHP 980

Query: 812  PAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ--- 868
            P+   P  P   +P S P P  P  PP L + Q+     PP P S  P+ + Q+A Q   
Sbjct: 981  PSAHPP--PLQLMPQSQPLPSSPAQPPGLTQSQNL----PPPPASHPPTGLHQVAPQPPF 1034

Query: 869  --------FPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQ---PSSIPVPSPDFP 917
                     PPP TPP   S    P     + Q P +  A         SS P+P+    
Sbjct: 1035 AQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIK 1094

Query: 918  PPPPESSLVFPPPPPSPVPAP-PPPPPPTASPTPDKSGSPGK 958
                E +L     P SP P P  P P PT   TP  +    +
Sbjct: 1095 ----EEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSAR 1132



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 122/437 (27%), Positives = 161/437 (36%), Gaps = 65/437 (14%)

Query: 734  APSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP-KPLVTIPAPTSTK 792
            +PS+P              Q + Q  PP    P  +  P P  APP  P +  P PT + 
Sbjct: 712  SPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGV-TPAPSSAPPGTPQLPTPGPTPSA 770

Query: 793  TV-----APVVTQAA--PPTPTPPVPPAKKQPAFPASYI--PPSPPTPPVPVPPPTL--- 840
            T      +P  +QA   P  PT PVP    Q A PA +   PPSP  PP P P P L   
Sbjct: 771  TAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQA-PALHPQRPPSPHPPPHPSPHPPLQPL 829

Query: 841  ------PKQQSFCAKPPPSPLSPVP-SVVKQIASQFPPPPTP---PAMESQPLKPVPANV 890
                  P   S    P      P P S+      Q P PP P   P   SQ   P+  + 
Sbjct: 830  TGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSP 889

Query: 891  APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP---PPPPSPVPAPPPP-----P 942
            A   P      P  Q S++    P    P P + L  P   PPP +P+P  P P     P
Sbjct: 890  AAAYPHTSLQLPASQ-SALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHP 948

Query: 943  PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSG-AEHPEPKRPSVDSLV 1001
            P  + P+P             S      PPP  +  SS+ +    + HP P +    S  
Sbjct: 949  PHLSGPSP------------FSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQP 996

Query: 1002 SKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSV 1061
               +P    G    + LPPP A   P  L+      P         A+ P + G G   +
Sbjct: 997  LPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPP--------FAQHPFVPG-GPPPI 1047

Query: 1062 VEFPSPPSDSDFPPPPPETELPLPPIEIPAV----FSGNTSPKVAVVNPQPQQWSKMSVK 1117
               P+ PS S  PP  P T    PP    A      +G +S  +  V  + +        
Sbjct: 1048 TP-PTCPSTST-PPAGPGTSAQ-PPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEP 1104

Query: 1118 KAPPPTRPKRNDSTRLT 1134
            ++PPP  P R+ S   T
Sbjct: 1105 ESPPP--PPRSPSPEPT 1119



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 97/390 (24%), Positives = 132/390 (33%), Gaps = 97/390 (24%)

Query: 830  TPPVPVPPP------TLPKQQSFCAKPP----PSPLSPVPSVVKQIASQFPPP-PTPPAM 878
            +P +P P        +  +QQ   A+PP    P+ ++P PS       Q P P PTP A 
Sbjct: 712  SPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSAT 771

Query: 879  ESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAP 938
               P     A+ AP  P A  A         PVP       P     + P  PPSP P P
Sbjct: 772  AVPPQGSPTASQAPNQPQAPTA---------PVPHTHIQQAPA----LHPQRPPSPHPPP 818

Query: 939  PPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVD 998
             P P P   P    +G P    S    P   + PP P    S+++    +HP P +P   
Sbjct: 819  HPSPHPPLQPLTGSAGQPSAP-SHAQPPLHGQGPPGPH---SLQAGPLLQHPGPPQPF-- 872

Query: 999  SLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGK 1058
                   P A  G     T P  A P        + + LP    Q  + ++ P       
Sbjct: 873  ----GLPPQASQGQAPLGTSPAAAYPH-------TSLQLPA--SQSALQSQQPPR----- 914

Query: 1059 DSVVEFPSPPSDSDFP--PPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSV 1116
                E P PP+    P   PPP T +P    ++PA  +    P ++  +P       M+ 
Sbjct: 915  ----EQPLPPAPLAMPHIKPPPTTPIP----QLPAPQAHKHPPHLSGPSP-----FSMNA 961

Query: 1117 KKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRK 1176
               PPP       S+  T    S  P    ++PQ    P S                   
Sbjct: 962  NLPPPPALKPL--SSLSTHHPPSAHPPPLQLMPQSQPLPSSP------------------ 1001

Query: 1177 SITRHGSLSSRMSRAEPTATMDDMALPPPP 1206
                          A+P        LPPPP
Sbjct: 1002 --------------AQPPGLTQSQNLPPPP 1017


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  136 bits (343), Expect = 1e-31
 Identities = 143/513 (27%), Positives = 195/513 (38%), Gaps = 61/513 (11%)

Query: 530  SSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEE 589
            +SS +KS         S +  ++++ S  + TQ      S S      S++  R    E 
Sbjct: 640  ASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDS--RSVNDEG 697

Query: 590  SSKAR-MESMNRPYTSLVPPLSPQPKIVTPYTASQPS-----PPLPPPPPPPPPPPPPPP 643
            SS  + ++  NR  +  +P  SPQ       +++Q       PP    P    P P   P
Sbjct: 698  SSDPKDIDQDNRSTSPSIP--SPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAP 755

Query: 644  PPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILV 703
            P  P LP+     + +A P      + T  Q  +Q        P   + Q+ ++ PQ   
Sbjct: 756  PGTPQLPTPGPTPSATAVP---PQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQR-- 810

Query: 704  PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTP 763
                  PP P PPP P+P   +  L  +   PS P  + PP   +     H  Q  P   
Sbjct: 811  ------PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ 864

Query: 764  PPPPPIPAPLPPQAPP--KPLVTIPAPTSTKT-----VAPVVTQAAPPTPTPPVPPAKKQ 816
             P PP P  LPPQA     PL T PA     T      +    Q+  P    P+PPA   
Sbjct: 865  HPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPL- 923

Query: 817  PAFPASYIPPSPPTPPVPVP-----PPTLPKQQSFCAK---PPPSPLSPVPSVVKQIASQ 868
             A P    PP+ P P +P P     PP L     F      PPP  L P+ S+       
Sbjct: 924  -AMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 869  FPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP 928
              PPP     +SQPL        P SP    A+P     S  +P P    PP     V P
Sbjct: 983  AHPPPLQLMPQSQPL--------PSSP----AQPPGLTQSQNLPPPPASHPPTGLHQVAP 1030

Query: 929  PPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKS-SSGA 987
             PP +  P  P  PPP   PT   + +P       + PG    PP     +S  S + G+
Sbjct: 1031 QPPFAQHPFVPGGPPPITPPTCPSTSTP------PAGPGTSAQPPCSGAAASGGSIAGGS 1084

Query: 988  EHPEP----KRPSVDSLVSKFTPPAESGSPSKE 1016
              P P    K  ++D      +PP    SPS E
Sbjct: 1085 SCPLPTVQIKEEALDDAEEPESPPPPPRSPSPE 1117



 Score =  115 bits (288), Expect = 3e-25
 Identities = 129/462 (27%), Positives = 169/462 (36%), Gaps = 80/462 (17%)

Query: 538  SSSSSIPESQSNHSNQSDSG---VSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEES---- 590
            S+S SIP  Q N S+   S    +   QP   +++ + V+   S A     QL       
Sbjct: 710  STSPSIPSPQDNESDSDSSAQQQMLQAQPPA-LQAPTGVTPAPSSAPPGTPQLPTPGPTP 768

Query: 591  SKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLP 650
            S   +     P  S  P     P    P+T  Q +P L P  PP P PPP P P PP   
Sbjct: 769  SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP--- 825

Query: 651  SQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVP 710
                P  GSA              +A  H+        PP   S    P +  P      
Sbjct: 826  --LQPLTGSAGQ-----------PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPG----- 867

Query: 711  PPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVA-PPTPPPPPPI 769
            PP P   PP      A L  +P A      + P   L++   Q   Q   PP   P PP 
Sbjct: 868  PPQPFGLPPQASQGQAPLGTSPAA------AYPHTSLQLPASQSALQSQQPPREQPLPPA 921

Query: 770  PAPLPPQAPPK--PLVTIPAPTSTKTVAPVVTQAAPPT-----PTPPV-----------P 811
            P  +P   PP   P+  +PAP + K   P ++  +P +     P PP            P
Sbjct: 922  PLAMPHIKPPPTTPIPQLPAPQAHKH-PPHLSGPSPFSMNANLPPPPALKPLSSLSTHHP 980

Query: 812  PAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQ--- 868
            P+   P  P   +P S P P  P  PP L + Q+     PP P S  P+ + Q+A Q   
Sbjct: 981  PSAHPP--PLQLMPQSQPLPSSPAQPPGLTQSQNL----PPPPASHPPTGLHQVAPQPPF 1034

Query: 869  --------FPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQ---PSSIPVPSPDFP 917
                     PPP TPP   S    P     + Q P +  A         SS P+P+    
Sbjct: 1035 AQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIK 1094

Query: 918  PPPPESSLVFPPPPPSPVPAP-PPPPPPTASPTPDKSGSPGK 958
                E +L     P SP P P  P P PT   TP  +    +
Sbjct: 1095 ----EEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSAR 1132



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 122/437 (27%), Positives = 161/437 (36%), Gaps = 65/437 (14%)

Query: 734  APSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP-KPLVTIPAPTSTK 792
            +PS+P              Q + Q  PP    P  +  P P  APP  P +  P PT + 
Sbjct: 712  SPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGV-TPAPSSAPPGTPQLPTPGPTPSA 770

Query: 793  TV-----APVVTQAA--PPTPTPPVPPAKKQPAFPASYI--PPSPPTPPVPVPPPTL--- 840
            T      +P  +QA   P  PT PVP    Q A PA +   PPSP  PP P P P L   
Sbjct: 771  TAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQA-PALHPQRPPSPHPPPHPSPHPPLQPL 829

Query: 841  ------PKQQSFCAKPPPSPLSPVP-SVVKQIASQFPPPPTP---PAMESQPLKPVPANV 890
                  P   S    P      P P S+      Q P PP P   P   SQ   P+  + 
Sbjct: 830  TGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSP 889

Query: 891  APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP---PPPPSPVPAPPPP-----P 942
            A   P      P  Q S++    P    P P + L  P   PPP +P+P  P P     P
Sbjct: 890  AAAYPHTSLQLPASQ-SALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHP 948

Query: 943  PPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSG-AEHPEPKRPSVDSLV 1001
            P  + P+P             S      PPP  +  SS+ +    + HP P +    S  
Sbjct: 949  PHLSGPSP------------FSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQP 996

Query: 1002 SKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSV 1061
               +P    G    + LPPP A   P  L+      P         A+ P + G G   +
Sbjct: 997  LPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPP--------FAQHPFVPG-GPPPI 1047

Query: 1062 VEFPSPPSDSDFPPPPPETELPLPPIEIPAV----FSGNTSPKVAVVNPQPQQWSKMSVK 1117
               P+ PS S  PP  P T    PP    A      +G +S  +  V  + +        
Sbjct: 1048 TP-PTCPSTST-PPAGPGTSAQ-PPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEP 1104

Query: 1118 KAPPPTRPKRNDSTRLT 1134
            ++PPP  P R+ S   T
Sbjct: 1105 ESPPP--PPRSPSPEPT 1119



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 97/390 (24%), Positives = 132/390 (33%), Gaps = 97/390 (24%)

Query: 830  TPPVPVPPP------TLPKQQSFCAKPP----PSPLSPVPSVVKQIASQFPPP-PTPPAM 878
            +P +P P        +  +QQ   A+PP    P+ ++P PS       Q P P PTP A 
Sbjct: 712  SPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSAT 771

Query: 879  ESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAP 938
               P     A+ AP  P A  A         PVP       P     + P  PPSP P P
Sbjct: 772  AVPPQGSPTASQAPNQPQAPTA---------PVPHTHIQQAPA----LHPQRPPSPHPPP 818

Query: 939  PPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVD 998
             P P P   P    +G P    S    P   + PP P    S+++    +HP P +P   
Sbjct: 819  HPSPHPPLQPLTGSAGQPSAP-SHAQPPLHGQGPPGPH---SLQAGPLLQHPGPPQPF-- 872

Query: 999  SLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGK 1058
                   P A  G     T P  A P        + + LP    Q  + ++ P       
Sbjct: 873  ----GLPPQASQGQAPLGTSPAAAYPH-------TSLQLPA--SQSALQSQQPPR----- 914

Query: 1059 DSVVEFPSPPSDSDFP--PPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSV 1116
                E P PP+    P   PPP T +P    ++PA  +    P ++  +P       M+ 
Sbjct: 915  ----EQPLPPAPLAMPHIKPPPTTPIP----QLPAPQAHKHPPHLSGPSP-----FSMNA 961

Query: 1117 KKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRK 1176
               PPP       S+  T    S  P    ++PQ    P S                   
Sbjct: 962  NLPPPPALKPL--SSLSTHHPPSAHPPPLQLMPQSQPLPSSP------------------ 1001

Query: 1177 SITRHGSLSSRMSRAEPTATMDDMALPPPP 1206
                          A+P        LPPPP
Sbjct: 1002 --------------AQPPGLTQSQNLPPPP 1017


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score =  129 bits (325), Expect = 1e-29
 Identities = 172/695 (24%), Positives = 249/695 (35%), Gaps = 116/695 (16%)

Query: 531  SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKR----GTQ 586
            SSS  + S S S     S+ S  S  G S+ QP     S S+V      + +     G+ 
Sbjct: 410  SSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGST 469

Query: 587  LEESSKARMES---MNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPP---PPPPPPPP 640
             E S    + S   ++    SL     P P     ++  Q    +P  P   PP P    
Sbjct: 470  AEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQ 529

Query: 641  PPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVM-------- 692
             P  P PP    S  +  +  P     S +  L       G   +PP  P          
Sbjct: 530  QPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLS-----PGGSRRPPRSPERTLSPSSGY 584

Query: 693  QSQSVKPQILVPPNGVVPPPPPP----PPPP-------TPGSAMAQLKPAPCAPSLPQFS 741
             SQS  P +  PP G+  PP  P    PP P       +PG++++    + C+ S     
Sbjct: 585  SSQSGTPTL--PPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSS----- 637

Query: 742  APPPPLKIHQVQHITQVAPP-TPPPPPPIPAPL--PPQAPPKPL---------VTIPAPT 789
            + P P      Q +T +      PP P +PAP   PP  P  P            +P P 
Sbjct: 638  SDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPV 697

Query: 790  STKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAK 849
            ST   +P     +PPTP   + P ++ P       PP  P P    PPP   K +     
Sbjct: 698  STTDASP----QSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEA 753

Query: 850  PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSI 909
            P  S  +  P     +     PPP PPA E Q L         ++  +V +     PS  
Sbjct: 754  PSASETAEEP-----LQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGS 808

Query: 910  P--VPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPG 967
            P  V SP        +  + PP  P P PAPP P P +++P    +  P K+    S  G
Sbjct: 809  PELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAP-GHVAKLPQKEPVGCSKGG 867

Query: 968  GKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKP 1027
            G   PP     + + +           PS+  +V   +  A  G+P+      P+AP KP
Sbjct: 868  G---PPREDVGAPLVT-----------PSLLQMVRLRSVGAPGGAPTPAL--GPSAPQKP 911

Query: 1028 GKLNLSG----VNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPP----- 1078
             +  LSG    V  P       V  KA  L+     S  +   PP     PP  P     
Sbjct: 912  LRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTAS 971

Query: 1079 ----------ETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRN 1128
                      + E P+ P E  A    N   ++  ++ Q    +     KAPPP      
Sbjct: 972  FIFSKGSRKLQLERPVSP-ETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPP------ 1024

Query: 1129 DSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQP 1163
                     ++ +P++    P  P+ P++     P
Sbjct: 1025 ---------VARKPSVGVPPPASPSYPRAEPLTAP 1050



 Score =  100 bits (250), Expect = 7e-21
 Identities = 113/448 (25%), Positives = 160/448 (35%), Gaps = 84/448 (18%)

Query: 613  PKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAP-------SAGSAAPMF- 664
            P+I+TP       PP P  P P  PPP  P  P P  P+ +AP       S   A+P   
Sbjct: 648  PQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSP 707

Query: 665  -VKYSTITRLQNASQHSGALFKPPTPPVMQSQ----SVKPQILVP--------------P 705
                +T+T LQ +   S     PP+PP         + KP+++V               P
Sbjct: 708  PTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDP 767

Query: 706  NGVVPPPPPPPP----------PPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHI 755
            N   PPPPPP P          PP   +  +   P P  PS        P         +
Sbjct: 768  NW--PPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATAL 825

Query: 756  TQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTS---TKTVAPVVTQAAPPTPTPPVPP 812
                P +P PPP  PAP P  + P  +  +P       +K   P       P  TP +  
Sbjct: 826  QIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQ 885

Query: 813  AKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFC--AKPPPSPLSPVPSVVKQIASQFP 870
              +  +  A   P   PTP +    P  P +++    A P P+P S + + V+  A    
Sbjct: 886  MVRLRSVGA---PGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLA 942

Query: 871  P--------PPTPPAMESQPLKPVPANVA---------------PQSPPA---------- 897
                     P  PP  E +P +  PA+ A               P SP            
Sbjct: 943  ASEGLSSAQPNGPPEAEPRPPQS-PASTASFIFSKGSRKLQLERPVSPETQADLQRNLVA 1001

Query: 898  -VKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSP 956
             +++  + +P   P  SP  PPP      V  PPP SP  + P   P TA PT     + 
Sbjct: 1002 ELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASP--SYPRAEPLTAPPTNGLPHTQ 1059

Query: 957  GKKTSKTSSPGGKKPPPTPQRNSSIKSS 984
             +   + +  GG      P+    +  S
Sbjct: 1060 DRTKRELAENGGVLQLVGPEEKMGLPGS 1087



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 117/457 (25%), Positives = 164/457 (35%), Gaps = 94/457 (20%)

Query: 527  TSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGH---VRSQSIVSSVFSEAWKR 583
            TSL S      SS +S+  S S+ +    SG     P G    +     V + FS    +
Sbjct: 617  TSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSK 676

Query: 584  GTQLEESSKARMESMNRPYTSLVPPLSPQ--PKIVTPYTASQPSPPLPP---PPPPPPP- 637
                  ++ A       P        SPQ  P   T  T  Q SP +     PPP PPP 
Sbjct: 677  PRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPS 736

Query: 638  --PPPPP--------------------------PPPPPPLPSQSAPSAGSAAPMFVKYST 669
              PPPPP                          PPPPPP P +   S     P    + +
Sbjct: 737  YHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFS 796

Query: 670  ITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA----- 724
            +   + A   SG+     +P    S +   QI  P +   P PPP PP P P S+     
Sbjct: 797  VASPEPAGP-SGSPELVSSPAASSSSATALQIQPPGS---PDPPPAPPAPAPASSAPGHV 852

Query: 725  --MAQLKPAPCA----PSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAP 778
              + Q +P  C+    P      AP     + Q+  +  V  P   P P     L P AP
Sbjct: 853  AKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPA----LGPSAP 908

Query: 779  PKPL--------VTIPAPTS-----------TKTVAPVVTQAAPPTPTPPVPPAKKQPAF 819
             KPL          +PAP+S           +   +  ++ A P  P    P   + PA 
Sbjct: 909  QKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPAS 968

Query: 820  PASYI------------PPSPPTPPVPVPPPTLPKQQSFCAKPPP-----SPLSPVPSVV 862
             AS+I            P SP T    +    + + +S   + PP     SP +P P V 
Sbjct: 969  TASFIFSKGSRKLQLERPVSPETQ-ADLQRNLVAELRSISEQRPPQAPKKSPKAP-PPVA 1026

Query: 863  KQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVK 899
            ++ +   PPP +P    ++PL   P N  P +    K
Sbjct: 1027 RKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTK 1063



 Score = 30.8 bits (68), Expect = 8.5
 Identities = 17/59 (28%), Positives = 27/59 (45%)

Query: 937 APPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRP 995
           A  PP  P A    +  G P +K S++ + G ++     +     K ++GAE  EP  P
Sbjct: 3   ARAPPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAAP 61


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score =  127 bits (319), Expect = 7e-29
 Identities = 150/514 (29%), Positives = 202/514 (39%), Gaps = 87/514 (16%)

Query: 527  TSLSS-SSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGT 585
            TSL+S S+  SG  S+   +SQS+  +     ++D  P+    +Q + S   SE    G 
Sbjct: 608  TSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSP---AQCVCSPPVSE----GP 660

Query: 586  QLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQP--------SPPLPPPPPPPPP 637
             L +S  + + +  +P  +   P+   P    P +  Q         +P LPPP  P P 
Sbjct: 661  VLPQSLPS-LGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPT 719

Query: 638  PPPPPPPP---PPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTP---PV 691
             P  P PP   PPPL +Q  P     AP       +  LQ    H      P +    P 
Sbjct: 720  GPGQPAPPGQQPPPL-AQPTPLPQVLAPQ-----PVVPLQPVPPHLPPYLAPASQVGAPA 773

Query: 692  MQSQSVKPQILVPPNGVVPPPPPP---PPPPTPGSAMAQLKPAPCAPSLPQFSAPP--PP 746
                   PQ  + P   VPP  PP    PP TP + +  L PA   P LP  + PP  PP
Sbjct: 774  QLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPA--LPDLPTATVPPVPPP 831

Query: 747  LKIHQVQHITQVAPPTPPPPPPIPA-----PLPPQAP---------PKPLVTIP----AP 788
                    +  +A P PP  P +P      P PP AP         P    TIP    AP
Sbjct: 832  QYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAP 891

Query: 789  TSTKTVA-----------PVVTQAAP---PTPTPPVPPAKKQ-----PAFPASYIPPSPP 829
                 ++           PV   A P   PT  PP P    Q     P  PA  +PP P 
Sbjct: 892  PGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPA--LPPQPT 949

Query: 830  TPPVPV--PPPTLPKQQSFCAKP--PPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKP 885
             PP PV  P PTLP Q     +P  PP P+ P P  +       PP P  P +  +PL+P
Sbjct: 950  LPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLP-PQPMLPPQPVLPPQPALP-VRPEPLQP 1007

Query: 886  -VPANVAPQSPPAVK---AKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPP 941
             +P   AP + P  +     P      +    P  P PP  ++++ PP P   +PA P  
Sbjct: 1008 HLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPP--AAVLSPPLPEVLLPAAPEL 1065

Query: 942  PPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP 975
             P   S     S S     ++T++      PP P
Sbjct: 1066 LPQFPSSLATVSASVQSVPTQTATLLPPANPPLP 1099



 Score =  100 bits (250), Expect = 7e-21
 Identities = 106/343 (30%), Positives = 136/343 (39%), Gaps = 67/343 (19%)

Query: 603  TSLVPPLSP----QPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQS-APSA 657
            T+ VPP+ P     P ++ P  A+ P PP  P  P      P PP  P  +P ++  P+A
Sbjct: 822  TATVPPVPPPQYFSPAVILPSLAA-PLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNA 880

Query: 658  GSAAPMFVK----------YSTITRLQNASQHSGALFK------PPTP--PVMQSQSVKP 699
             +  P+             +S + +L     +  A  +      PP+P   V   ++  P
Sbjct: 881  PATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPP 940

Query: 700  QILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVA 759
            Q  +PP   +PP P  PP PT       L P P  P  PQ + PP P+   Q      + 
Sbjct: 941  QPALPPQPTLPPQPVLPPQPT-------LPPQPVLP--PQPTRPPQPVLPPQ-----PML 986

Query: 760  PPTP--PPPPPIPAPLPPQAPPKPLVTIPAPTSTKTV-----APVVTQAAPPTPTPPVPP 812
            PP P  PP P +P    P  P  P    PA T    +     AP     A   PT PVPP
Sbjct: 987  PPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPP 1046

Query: 813  AKKQPAFPASYIPPSPPTPPV--PVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFP 870
            A             SPP P V  P  P  LP+  S  A    S    V SV  Q A+  P
Sbjct: 1047 AAVL----------SPPLPEVLLPAAPELLPQFPSSLATVSAS----VQSVPTQTATLLP 1092

Query: 871  P--PPTP--PAMESQPLKPVPANVAP-QSPPAVKAKPKWQPSS 908
            P  PP P  P + S P   V   V P Q   A + KP   P S
Sbjct: 1093 PANPPLPGGPGIAS-PCPTVQLTVEPVQEEQASQDKPPGLPQS 1134



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 63/231 (27%), Positives = 87/231 (37%), Gaps = 25/231 (10%)

Query: 711  PPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIP 770
            P  P   PP P S++        AP   Q S+   P  +   Q ++Q  P  PP  PP  
Sbjct: 1324 PEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPP-- 1381

Query: 771  APLPPQAPPKPLVTIP----APTSTKTVAPVVTQAA----PPTPTPPVPPAKKQPAFPAS 822
            APL P +PP  +  +P    AP ++    P    A+    P TP       +       +
Sbjct: 1382 APLAPSSPP--VTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAET 1439

Query: 823  YIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQP 882
            +  P    P V    P  P  ++   +   +P  P+P           P P+P +   QP
Sbjct: 1440 HEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPA--------PEPSPHSGTPQP 1491

Query: 883  LKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPP---ESSLVFPPP 930
                PA + P +  AV       PS  P   P  PP PP   ES    PPP
Sbjct: 1492 ALGQPAPLLPAAVGAVSLATSQLPS--PPLGPTVPPQPPSALESDGEGPPP 1540



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 56/222 (25%), Positives = 76/222 (34%), Gaps = 34/222 (15%)

Query: 629  PPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPT 688
            P P  P   PP P    PP     SAP     +    +  +    Q     +G    P  
Sbjct: 1322 PAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSK--EQPSFLASQQLLSQAGPSNPPGA 1379

Query: 689  PPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLK 748
            PP   + S  P   +P +G  P     P P + G+A     P        +     P  +
Sbjct: 1380 PPAPLAPSSPPVTALPQDGAAPATSTMPEPAS-GTASQAGGPGTPQGLTSELETSQPLAE 1438

Query: 749  IHQVQHITQ-----VAPPTPPP---------------PPPIPAPLPPQAPPKPLVTIPAP 788
             H+     Q     +AP TP P               PPP P P P    P+P +  PAP
Sbjct: 1439 THEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAP 1498

Query: 789  TSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPT 830
                 V   V+ A    P+PP+ P           +PP PP+
Sbjct: 1499 LLPAAVG-AVSLATSQLPSPPLGPT----------VPPQPPS 1529



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 71/221 (32%), Positives = 83/221 (37%), Gaps = 29/221 (13%)

Query: 873  PTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPP 932
            P P A ES P  P+P +  P       A  K Q SS   PS  F       S   P  PP
Sbjct: 1322 PAPEAPESSP--PLPLSSLPPEASQDSAPYKDQLSSKEQPS--FLASQQLLSQAGPSNPP 1377

Query: 933  SPVPAP--PPPPPPTASP----TPDKSGSPGKKTSKTSSPGGKKPPPTPQ-RNSSIKSSS 985
               PAP  P  PP TA P     P  S  P   +   S  GG   P TPQ   S +++S 
Sbjct: 1378 GAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGG---PGTPQGLTSELETSQ 1434

Query: 986  GAEHPEPKRPSVDSLVSKFTP--PA------ESGSPSKETLPPPAAPPKPGKLNLSGVNL 1037
                      +V  LV    P  PA         S  +E LPPPA  P P     SG   
Sbjct: 1435 PLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPH----SGTPQ 1490

Query: 1038 PGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPP 1078
            P +   G  +   P   G    +  + PSPP     PP PP
Sbjct: 1491 PAL---GQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPP 1528



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 66/249 (26%), Positives = 90/249 (36%), Gaps = 29/249 (11%)

Query: 633  PPPPPPPPPPPPPPPPLPSQSAPSAGS--AAPMFVKYST-----ITRLQNASQHSGALFK 685
            P    P P  P   PPLP  S P   S  +AP   + S+         Q     +G    
Sbjct: 1317 PVAEHPAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNP 1376

Query: 686  PPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPP 745
            P  PP   + S  P   +P +G  P     P P + G+A     P        +     P
Sbjct: 1377 PGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPAS-GTASQAGGPGTPQGLTSELETSQP 1435

Query: 746  PLKIHQVQHITQ-----VAPPTPPPPPP----IPAPLPPQAPPKPLVTIPAPTSTKTVAP 796
              + H+     Q     +AP TP P         AP  P  PP P    P+P S  T  P
Sbjct: 1436 LAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPE---PSPHSG-TPQP 1491

Query: 797  VVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLS 856
             + Q     P P +P A    +   S +P  P  P VP  PP+  +      + PP  + 
Sbjct: 1492 ALGQ-----PAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESD---GEGPPPRVG 1543

Query: 857  PVPSVVKQI 865
             V S +K +
Sbjct: 1544 FVDSTIKSL 1552



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 95/445 (21%), Positives = 143/445 (32%), Gaps = 61/445 (13%)

Query: 600  RPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPP---PPPPLPSQSAPS 656
            +P    + P +P P+  +   AS P  PLPPP P P P    P P    P PL     P+
Sbjct: 1447 QPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPL----LPA 1502

Query: 657  AGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPP 716
            A  A  +                  A  + P+PP+  +   +P   +  +G  PPP    
Sbjct: 1503 AVGAVSL------------------ATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGF 1544

Query: 717  PPPTPGSAMAQLKPAPCAPSLPQFSAPP-PPLKIHQVQHITQVAPPTPP----------- 764
               T  S   +L+       +P  SA    P+++       +      P           
Sbjct: 1545 VDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLAL 1604

Query: 765  PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAK--------KQ 816
            PP P  A       P+PLV       T+    V+ Q    + T    P          +Q
Sbjct: 1605 PPVPKEAVSGRVQLPQPLVEKSELAPTR--GAVMEQGTSSSMTAESSPRSMLGYDRDGRQ 1662

Query: 817  PAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPP 876
             A  +  +P  P   P  V P  +        +   S   P PS +  +  Q   P T  
Sbjct: 1663 VASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLG 1722

Query: 877  AMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVP 936
            A      +  P      SP     +      S+     ++    P S     PP      
Sbjct: 1723 ARALGSPRKRPEQQDVSSPAKTVGR-----FSVVSTQDEWTLASPHSLRYSAPPDVYLDE 1777

Query: 937  APPPPPPPTASPTPDKSGS----PGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEP 992
            AP  P    A      + S     G+  S  S   G +  P  Q+ +S+  S        
Sbjct: 1778 APSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFV 1837

Query: 993  KRPSVDSLVSKFTPPAESGSPSKET 1017
            K+ +     +    P+ +GS   ET
Sbjct: 1838 KKAT-----AFLQRPSRAGSLGPET 1857


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score =  126 bits (317), Expect = 1e-28
 Identities = 186/757 (24%), Positives = 246/757 (32%), Gaps = 211/757 (27%)

Query: 620  TASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQH 679
            T   P  PLPPPP PPPPPPPPPPPPP P  + S P   +   +   +ST+       + 
Sbjct: 238  TGLPPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGL---WSTLHGDAWGPER 294

Query: 680  SGALFKPPTPPVMQSQS---------VKPQILVPPNG--VVPPPPPPPPPPTPGSAMAQL 728
             G+      PP  Q Q            P     P G  +VP  PP P P  PG      
Sbjct: 295  KGS-----APPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPG------ 343

Query: 729  KPAPCAPSLPQFSAPPPPLKIHQVQH-----------ITQVAPPTPPPPPPIPAPLPPQA 777
              A     LP    P   L+  +VQ             T   P  P  PP +P      +
Sbjct: 344  --AESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSS 401

Query: 778  PP----------KPLVTIPAPTSTKTVAPVVTQ--------------------AAPPTPT 807
                        +P   IP     +T A  V+                     A P    
Sbjct: 402  SSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSL 461

Query: 808  PPVPPAKKQPAFPASYIPPSPPT--------------------------PPVPVPPPTLP 841
            PP P +   P  P    PP PP                           PP P PPP LP
Sbjct: 462  PPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPP-LP 520

Query: 842  KQQSFCAKP-------------PPSPLSPVPSVVKQIAS----------QFPPPP-TPPA 877
             ++ F   P             PP+P +P  S     +            FPPPP    +
Sbjct: 521  HREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARS 580

Query: 878  MESQPLKPVPANVAPQSPPAVK---AKPKWQPSSI------PVPSPDFPPPP---PESSL 925
            ++  P  P PA   PQ PP V    A P   PSS           P+ P P    P++  
Sbjct: 581  IDPLPRPPSPAQ-NPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPE 639

Query: 926  VFPPPPPSPVPAPPPPPPPTAS-------------PTP--DKSGSPG------------- 957
            V P PPP P+   P P PP                PTP  D+   P              
Sbjct: 640  VGPGPPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIM 699

Query: 958  --------KKTSKTSSPGGKKP-PPTPQRNSSIKSSSGAE-HPEPKRPSVDSLVSKFTPP 1007
                    K+  +     G  P PP  +  +S++S    +  P    P+V    +  T  
Sbjct: 700  KMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTT 759

Query: 1008 AESGSPSKETLPPPAAPPKPGKLNLSGVNL------PGVLQQGCVSAKAPVLSG-----R 1056
              + +  +E  PPPA PP P        +       P       + + A VL G     R
Sbjct: 760  TTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYR 819

Query: 1057 GKDSVVEF-PSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMS 1115
            G  + V   P P   + + P PP     LPP        G         +PQP   S   
Sbjct: 820  GTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQG---------SPQPSASSSSQ 870

Query: 1116 VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPG-----FLADLN 1170
               +  P   +R            E+P      P  PT P   LS+ P       L +++
Sbjct: 871  FSTSGGPWARER---------RAGEEPVPG---PMTPTQPPPPLSLPPARSESEVLEEIS 918

Query: 1171 R---TLQRKSITRHGSLSSRMSRAEPTATMDDMALPP 1204
            R   TL  +        +  +  AEP  +  +  LPP
Sbjct: 919  RACETLVERVGRSATDPADPVDTAEPADSGTERLLPP 955



 Score =  111 bits (277), Expect = 5e-24
 Identities = 162/660 (24%), Positives = 224/660 (33%), Gaps = 138/660 (20%)

Query: 619  YTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQ 678
            Y A +  PP+     PP   P PP     P   +     G             R    S+
Sbjct: 188  YGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGK-----------RRRGCNSE 236

Query: 679  HSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMA---QLKPAPCAP 735
             +G     P PP             PP    PPPPPPPPPP PG A +   QL       
Sbjct: 237  QTGLPPGLPLPP-------------PPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWS 283

Query: 736  SL------PQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPT 789
            +L      P+     PP +  Q   +        P P P PAP     PP   +   AP 
Sbjct: 284  TLHGDAWGPERKGSAPPERQEQRHSL--------PHPYPYPAPAYTAHPPGHRLVPAAPP 335

Query: 790  STKTVAP-VVTQAAPPTPTPPVPPAKK------------QPAFPASYIPPSPPTPPVPVP 836
                  P   +    P   PP    ++             PA   + +P +P  PP  +P
Sbjct: 336  GPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPP-GLP 394

Query: 837  PPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPP 896
              T     S  +      + P P +      Q       PA+E      +  +      P
Sbjct: 395  GTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQ------TPALEVSHHGRLGPSAHSSRKP 448

Query: 897  AVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAP------------------ 938
             + A       S+P P P  PPPPP   L+ PPPPP+ +  P                  
Sbjct: 449  FLGAPAATPHLSLP-PGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFG 507

Query: 939  -PPPPPPTASPTPDKSGSPGKKTSK----TSSPGGKKPPPTPQRNSSIKSSSGAEHPEPK 993
               PP P   P P + G  G   S+    T        PPTP  +SS  S+SG+    P 
Sbjct: 508  TEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSS-NSNSGSHSSSPA 566

Query: 994  RP-----------SVDSLVSKFTPPAESGSPSKETLPP-----PAAPPKPGKLNLSGVNL 1037
             P           S+D L     PP+ + +P    L P     P APP     N SG   
Sbjct: 567  GPVSFPPPPYLARSIDPLP---RPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSG--- 620

Query: 1038 PGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLP--------PIEI 1089
                     S + P  S R +   V FP  P     PPP P ++ P P        P   
Sbjct: 621  ---------SFRRPE-SPRPR---VSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARG 667

Query: 1090 PAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVP 1149
            P +F    +P    +  Q ++ ++  +         K  D +   + E  +Q   A V P
Sbjct: 668  PRLFDFPPTP----LEDQFEEPAEFKILPDGLANIMKMLDES--IRKEEEQQQHEAGVAP 721

Query: 1150 QVPTSPKSSLSVQPGFLADL--NRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207
            Q P   +   S+Q  F  D     T    ++T   + ++  +  +        ALPPPPP
Sbjct: 722  QPPLK-EPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPP 780



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 132/543 (24%), Positives = 194/543 (35%), Gaps = 84/543 (15%)

Query: 570  QSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIV--------TPYTA 621
            +SI      +  + G   +   K    S+  P+ +   P +  P +         T  TA
Sbjct: 704  ESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTA 763

Query: 622  SQ-----PSPPLPPPPPP---PPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRL 673
            +Q     P P LPPPPP    PPP  P PPPPPPP P+    S  S      KY      
Sbjct: 764  TQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEG-QKYCYRGTG 822

Query: 674  QNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPC 733
               S   G     P P    S         PP+G    PP    P   GS      P P 
Sbjct: 823  AAVSTRPG-----PLPTTQYSPG-------PPSGATALPPTSAAPSAQGS------PQPS 864

Query: 734  APSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKT 793
            A S  QFS    P            A        P+P P+ P  PP PL   PA + ++ 
Sbjct: 865  ASSSSQFSTSGGPW-----------ARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEV 913

Query: 794  VAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPS 853
            +  +    A  T    V  +   PA P     P+       +PP          AK    
Sbjct: 914  LEEI--SRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQ--------AKEEAG 963

Query: 854  PLSPVPSVVKQIASQFPPP---PTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIP 910
             ++ V    K+   +             +S   +P     A       K K +    ++ 
Sbjct: 964  GVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGR-AKAKAKVPKEKSRRVLGNLD 1022

Query: 911  VPSPDF---PPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPG 967
            + S +        P+        PP+  PAPP  P P+A PTP  +  PGKK ++  +PG
Sbjct: 1023 LQSEEIQGREKSRPDLGGASKAKPPT-APAPPSAPAPSAQPTPPSASVPGKK-AREEAPG 1080

Query: 968  GKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKP 1027
                PP   R   +K  S +E P PK   +  +        ESG   KET    A+  + 
Sbjct: 1081 ----PPGVSRADMLKLRSLSEGP-PKELKIRLI------KVESG--DKETF--IASEVEE 1125

Query: 1028 GKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPI 1087
             +L ++ + +         +++   + G+ ++S +     P+ S  P    E +LP   +
Sbjct: 1126 RRLRMADLTISHCAADVVRASRNAKVKGKFRESYLS----PAQSVKPKINTEEKLPREKL 1181

Query: 1088 EIP 1090
              P
Sbjct: 1182 NPP 1184



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 122/518 (23%), Positives = 169/518 (32%), Gaps = 114/518 (22%)

Query: 608  PLSPQPKIVTPYTASQPSPPLPPPPPPPP--PPPPPPPP---------------PPPPLP 650
            P SP+P++  P T     P + P PPP P    P P PP               PP PL 
Sbjct: 625  PESPRPRVSFPKT-----PEVGPGPPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLE 679

Query: 651  SQSAPSA-------GSAAPMFVKYSTITRLQNASQH-SGALFKPP-TPPVMQSQSVKPQI 701
             Q    A       G A  M +   +I + +   QH +G   +PP   P    QS  P  
Sbjct: 680  DQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTD 739

Query: 702  LVPPN---GVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQV 758
              P      V           T  +   + KP P  P       PPPPL           
Sbjct: 740  TAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALP-------PPPPL----------- 781

Query: 759  APPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPA 818
                PPP  P P P PP +P   L ++ +    +      T AA  T   P+        
Sbjct: 782  -AKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPL-------- 832

Query: 819  FPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM 878
             P +   P PP+    +PP          +  P +  SP PS     +SQF     P A 
Sbjct: 833  -PTTQYSPGPPSGATALPP---------TSAAPSAQGSPQPSA--SSSSQFSTSGGPWAR 880

Query: 879  ESQP-LKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPA 937
            E +   +PVP  + P  PP               P    PP   ES ++           
Sbjct: 881  ERRAGEEPVPGPMTPTQPP---------------PPLSLPPARSESEVLEEISRACETLV 925

Query: 938  PPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGA---------- 987
                   T    P  +  P    ++   P    P    +    + + SG+          
Sbjct: 926  ERVGRSATDPADPVDTAEPADSGTERLLP----PAQAKEEAGGVAAVSGSCKRRQKEHQK 981

Query: 988  EHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVS 1047
            EH   +R   DS+  +   P E  + +K  +P   +    G L+L    + G        
Sbjct: 982  EHRRHRRACKDSVGRR---PREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQG------RE 1032

Query: 1048 AKAPVLSGRGKDSVVEFPSPPS--DSDFPPPPPETELP 1083
               P L G  K      P+PPS       P PP   +P
Sbjct: 1033 KSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVP 1070



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 24/81 (29%), Positives = 29/81 (35%), Gaps = 3/81 (3%)

Query: 917 PPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQ 976
           PP PP  S   P    S     PP P P        SG P K      +PG   P P   
Sbjct: 32  PPHPPPRSAWLPGGRCSASIGQPPLPAPLPPSHGSSSGHPSK---PYYAPGAPTPRPLHG 88

Query: 977 RNSSIKSSSGAEHPEPKRPSV 997
           +  S+     A   EP +P +
Sbjct: 89  KLESLHGCVQALLREPAQPGL 109


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.128    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,754,178
Number of Sequences: 37866
Number of extensions: 6340857
Number of successful extensions: 299915
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1892
Number of HSP's successfully gapped in prelim test: 2164
Number of HSP's that attempted gapping in prelim test: 45071
Number of HSP's gapped (non-prelim): 78698
length of query: 1250
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1136
effective length of database: 13,930,794
effective search space: 15825381984
effective search space used: 15825381984
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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