BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] (733 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] 1465 0.0 gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] 1458 0.0 gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] 1273 0.0 gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] 1084 0.0 gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 7e-10 gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 7e-10 gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 7e-10 gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 7e-10 gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 62 2e-09 gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 62 2e-09 gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 59 1e-08 gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 57 5e-08 gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 57 5e-08 gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 57 5e-08 gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens] 56 1e-07 gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 56 1e-07 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 55 2e-07 gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 55 3e-07 gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 54 5e-07 gi|109689723 abl interactor 2 [Homo sapiens] 54 5e-07 gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 54 5e-07 gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 53 9e-07 gi|21735415 centromere protein B [Homo sapiens] 53 9e-07 gi|17975763 myelin transcription factor 1 [Homo sapiens] 53 9e-07 gi|55749544 SH3 multiple domains 1 [Homo sapiens] 52 2e-06 gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens] 51 4e-06 gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens] 51 4e-06 gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 51 4e-06 gi|58761548 tau tubulin kinase 1 [Homo sapiens] 51 4e-06 gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 51 4e-06 >gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] Length = 733 Score = 1465 bits (3792), Expect = 0.0 Identities = 733/733 (100%), Positives = 733/733 (100%) Query: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK Sbjct: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60 Query: 61 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE Sbjct: 61 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120 Query: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL Sbjct: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180 Query: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV Sbjct: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240 Query: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS Sbjct: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300 Query: 301 RGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ 360 RGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ Sbjct: 301 RGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ 360 Query: 361 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS 420 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS Sbjct: 361 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS 420 Query: 421 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS 480 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS Sbjct: 421 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS 480 Query: 481 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ 540 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ Sbjct: 481 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ 540 Query: 541 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL 600 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL Sbjct: 541 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL 600 Query: 601 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC 660 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC Sbjct: 601 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC 660 Query: 661 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ 720 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ Sbjct: 661 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ 720 Query: 721 TYDFLGEMRKNAV 733 TYDFLGEMRKNAV Sbjct: 721 TYDFLGEMRKNAV 733 >gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] Length = 732 Score = 1458 bits (3775), Expect = 0.0 Identities = 732/733 (99%), Positives = 732/733 (99%), Gaps = 1/733 (0%) Query: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK Sbjct: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60 Query: 61 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE Sbjct: 61 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120 Query: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL Sbjct: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180 Query: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV Sbjct: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240 Query: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS Sbjct: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300 Query: 301 RGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ 360 RGRIFLVSKPVLQ INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ Sbjct: 301 RGRIFLVSKPVLQ-INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ 359 Query: 361 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS 420 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS Sbjct: 360 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS 419 Query: 421 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS 480 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS Sbjct: 420 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS 479 Query: 481 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ 540 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ Sbjct: 480 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ 539 Query: 541 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL 600 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL Sbjct: 540 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL 599 Query: 601 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC 660 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC Sbjct: 600 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC 659 Query: 661 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ 720 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ Sbjct: 660 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ 719 Query: 721 TYDFLGEMRKNAV 733 TYDFLGEMRKNAV Sbjct: 720 TYDFLGEMRKNAV 732 >gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] Length = 677 Score = 1273 bits (3293), Expect = 0.0 Identities = 656/737 (89%), Positives = 664/737 (90%), Gaps = 64/737 (8%) Query: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK Sbjct: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60 Query: 61 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE Sbjct: 61 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120 Query: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL Sbjct: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180 Query: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEED Sbjct: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEED------------- 227 Query: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDT-NGSETGFRA---W 296 +E V++T +G+E R W Sbjct: 228 ---------------------------------------VEAVDETADGAEVKQRTDPHW 248 Query: 297 NVQSRGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL 356 + V K + +QINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL Sbjct: 249 SA--------VQKAISEQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL 300 Query: 357 MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN 416 MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN Sbjct: 301 MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN 360 Query: 417 KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY 476 KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY Sbjct: 361 KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY 420 Query: 477 IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS 536 IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS Sbjct: 421 IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS 480 Query: 537 VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD 596 VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD Sbjct: 481 VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD 540 Query: 597 RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV 656 RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV Sbjct: 541 RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV 600 Query: 657 YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD 716 YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD Sbjct: 601 YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD 660 Query: 717 LSEQTYDFLGEMRKNAV 733 LSEQTYDFLGEMRKNAV Sbjct: 661 LSEQTYDFLGEMRKNAV 677 >gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] Length = 614 Score = 1084 bits (2803), Expect = 0.0 Identities = 578/738 (78%), Positives = 595/738 (80%), Gaps = 129/738 (17%) Query: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60 MLARRQRDPLQALRRRNQELKQQVDSLLSESQ LK+A++ NK Sbjct: 1 MLARRQRDPLQALRRRNQELKQQVDSLLSESQ-------------------LKEALEPNK 41 Query: 61 NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE-VGAPTEEEE 119 R++I + VGAPTEEEE Sbjct: 42 --------------------------------------------RQHIYQRVGAPTEEEE 57 Query: 120 ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 179 ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL Sbjct: 58 ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 117 Query: 180 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 239 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE +G+E Sbjct: 118 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE--------------EGSE 163 Query: 240 VKQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDT-NGSETGFRA--- 295 +E V++T +G+E R Sbjct: 164 --------------------------------------EDVEAVDETADGAEVKQRTDPH 185 Query: 296 WNVQSRGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE 355 W+ + + +INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE Sbjct: 186 WSAVQKA---------ISEINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPE 236 Query: 356 LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG 415 LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG Sbjct: 237 LMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG 296 Query: 416 NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS 475 NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS Sbjct: 297 NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGIS 356 Query: 476 YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG 535 YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG Sbjct: 357 YIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHG 416 Query: 536 SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK 595 SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK Sbjct: 417 SVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK 476 Query: 596 DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL 655 DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL Sbjct: 477 DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLL 536 Query: 656 VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF 715 VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF Sbjct: 537 VYHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPF 596 Query: 716 DLSEQTYDFLGEMRKNAV 733 DLSEQTYDFLGEMRKNAV Sbjct: 597 DLSEQTYDFLGEMRKNAV 614 >gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform 9 [Homo sapiens] Length = 771 Score = 63.5 bits (153), Expect = 7e-10 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%) Query: 3 ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58 +RR+RD L+ L R+R +E K QQ + + + + A E K + + + + E Sbjct: 150 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 209 Query: 59 NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106 + + K S S P + K EE LL L T S E Sbjct: 210 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 269 Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166 + + EEEE E E+ E+ G E++EEEEEE+EE E S EE + +A+ Sbjct: 270 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 326 Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219 +V + + E +L+V E + D +D+ +E E E EG Sbjct: 327 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 373 Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263 S +E D E+KQ + A+Q S CL Sbjct: 374 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 417 >gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform 5 [Homo sapiens] Length = 748 Score = 63.5 bits (153), Expect = 7e-10 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%) Query: 3 ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58 +RR+RD L+ L R+R +E K QQ + + + + A E K + + + + E Sbjct: 127 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 186 Query: 59 NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106 + + K S S P + K EE LL L T S E Sbjct: 187 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 246 Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166 + + EEEE E E+ E+ G E++EEEEEE+EE E S EE + +A+ Sbjct: 247 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 303 Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219 +V + + E +L+V E + D +D+ +E E E EG Sbjct: 304 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 350 Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263 S +E D E+KQ + A+Q S CL Sbjct: 351 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 394 >gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform 4 [Homo sapiens] Length = 737 Score = 63.5 bits (153), Expect = 7e-10 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%) Query: 3 ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58 +RR+RD L+ L R+R +E K QQ + + + + A E K + + + + E Sbjct: 116 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 175 Query: 59 NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106 + + K S S P + K EE LL L T S E Sbjct: 176 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 235 Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166 + + EEEE E E+ E+ G E++EEEEEE+EE E S EE + +A+ Sbjct: 236 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 292 Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219 +V + + E +L+V E + D +D+ +E E E EG Sbjct: 293 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 339 Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263 S +E D E+KQ + A+Q S CL Sbjct: 340 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 383 >gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2 [Homo sapiens] Length = 782 Score = 63.5 bits (153), Expect = 7e-10 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%) Query: 3 ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58 +RR+RD L+ L R+R +E K QQ + + + + A E K + + + + E Sbjct: 161 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 220 Query: 59 NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106 + + K S S P + K EE LL L T S E Sbjct: 221 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 280 Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166 + + EEEE E E+ E+ G E++EEEEEE+EE E S EE + +A+ Sbjct: 281 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 337 Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219 +V + + E +L+V E + D +D+ +E E E EG Sbjct: 338 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 384 Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263 S +E D E+KQ + A+Q S CL Sbjct: 385 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 428 >gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] Length = 770 Score = 62.0 bits (149), Expect = 2e-09 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%) Query: 3 ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58 +RR+RD L+ L R+R +E K QQ + + + + A E K + + + + E Sbjct: 149 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 208 Query: 59 NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106 + + K S S P + K EE LL L T S E Sbjct: 209 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 268 Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166 + + EEEE E E+ E+ G E++EEEEEE+EE E S EE + +A+ Sbjct: 269 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 325 Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219 +V + + E +L+V E + D +D+ +E E E EG Sbjct: 326 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 372 Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263 S +E D E+KQ + A+Q S CL Sbjct: 373 SSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCL 416 >gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] Length = 780 Score = 62.0 bits (149), Expect = 2e-09 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%) Query: 3 ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58 +RR+RD L+ L R+R +E K QQ + + + + A E K + + + + E Sbjct: 159 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 218 Query: 59 NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106 + + K S S P + K EE LL L T S E Sbjct: 219 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 278 Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166 + + EEEE E E+ E+ G E++EEEEEE+EE E S EE + +A+ Sbjct: 279 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 335 Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219 +V + + E +L+V E + D +D+ +E E E EG Sbjct: 336 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 382 Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263 S +E D E+KQ + A+Q S CL Sbjct: 383 SSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCL 426 >gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform 8 [Homo sapiens] Length = 780 Score = 59.3 bits (142), Expect = 1e-08 Identities = 67/282 (23%), Positives = 111/282 (39%), Gaps = 36/282 (12%) Query: 2 LARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLK-QAIDENK 60 L R + + L+ R R +++++Q + + + E +++ +R + + + E+ Sbjct: 161 LFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 220 Query: 61 NALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRENI 108 + K S S P + K EE LL L T S E+ Sbjct: 221 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESS 280 Query: 109 TEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168 + EEEE E E+ E+ G E++EEEEEE+EE E S EE + +A++V Sbjct: 281 SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEV 337 Query: 169 GDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE 221 + + E +L+V E + D +D+ +E E E EG S Sbjct: 338 SEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSS 384 Query: 222 EGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263 +E D E+KQ + A+Q S CL Sbjct: 385 ALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 426 >gi|194294523 intersectin 2 isoform 3 [Homo sapiens] Length = 1670 Score = 57.4 bits (137), Expect = 5e-08 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%) Query: 131 GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 186 G E EE E ++ S +S GEEYIA+ +++ + GDLTF +GE +LV +K Sbjct: 929 GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 986 Query: 187 DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235 DG W G+ P Y++P +E G S S + E T+ Sbjct: 987 DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1035 Score = 51.2 bits (121), Expect = 3e-06 Identities = 56/227 (24%), Positives = 96/227 (42%), Gaps = 34/227 (14%) Query: 2 LARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKN 61 L +R ++ L AL + ++DS +QLKE E Q + L+Q ++ Sbjct: 591 LCQRLKEQLDALEKETASKLSEMDSF--NNQLKELRETYNTQQL-----ALEQLYKIKRD 643 Query: 62 ALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEES 121 L+++ + Q+K+ E K Q +EN+ + EEEE+ Sbjct: 644 KLKEIERKR-----LELMQKKKLEDEAARKAKQ---------GKENLWKENLRKEEEEKQ 689 Query: 122 ESEDSEDSGGEEEDAEEEEEEK----------EENESHKWSTGEEYIAVGDFTAQQVGDL 171 + E + + ++ E + EEK EE + S Y A+ F A+ ++ Sbjct: 690 KRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEM 749 Query: 172 TFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 215 +F G+I+ V EK + W+ +GN G P Y+E P SE E+ Sbjct: 750 SFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796 Score = 39.7 bits (91), Expect = 0.010 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%) Query: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 215 + IA+ D+ A +L+F KG+++ V+ K WW + G GL P Y++ ++ + Sbjct: 1104 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1162 Query: 216 GQE 218 Q+ Sbjct: 1163 SQQ 1165 Score = 33.9 bits (76), Expect = 0.55 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%) Query: 159 AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 218 A+ +TA++ L F K +I+ V+E++ + WW + G G P++Y++ E +E Sbjct: 878 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 935 Query: 219 SSE 221 E Sbjct: 936 EPE 938 Score = 32.7 bits (73), Expect = 1.2 Identities = 64/268 (23%), Positives = 106/268 (39%), Gaps = 30/268 (11%) Query: 2 LARRQRDPLQALRRR---NQELKQQVDSLLSESQLK------EALEPNKRQHIYQRCIQL 52 L R++R + +RR+ NQ+ ++Q + + S+ K EAL K Q I R + Sbjct: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALN-GKHQQISGRLQDV 512 Query: 53 KQAIDENKNALQKLSKAD--ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISR---EN 107 + K L+ L K E + Q +E L L + Q L I N Sbjct: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572 Query: 108 ITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQ 167 + G ++ E E+ E+ DA E+E + +E ++ + + T Q Sbjct: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQL 632 Query: 168 VGDLTFK----------KGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQ 217 + +K + + L+ +KK + K +G E L + EEEE Q Sbjct: 633 ALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRK---EEEEKQ 689 Query: 218 ESSEEGSEEDVEAVDETADGAEVKQRTD 245 + +E E+ E + E AE KQR D Sbjct: 690 KRLQE--EKTQEKIQEEERKAEEKQRKD 715 >gi|194294521 intersectin 2 isoform 1 [Homo sapiens] Length = 1697 Score = 57.4 bits (137), Expect = 5e-08 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%) Query: 131 GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 186 G E EE E ++ S +S GEEYIA+ +++ + GDLTF +GE +LV +K Sbjct: 956 GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013 Query: 187 DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235 DG W G+ P Y++P +E G S S + E T+ Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062 Score = 45.8 bits (107), Expect = 1e-04 Identities = 56/236 (23%), Positives = 101/236 (42%), Gaps = 25/236 (10%) Query: 2 LARRQRDPLQALRRRNQELKQQVDSL--------LSESQLKEALEP-NKRQHIYQRCIQL 52 L +R ++ L AL + ++DS + +S L+ L + +++ +L Sbjct: 591 LCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKEL 650 Query: 53 KQAIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVG 112 ++ + + AL++L K +RK E KL + A +EN+ + Sbjct: 651 RETYNTQQLALEQLYKIKRDK--LKEIERKRLELMQKKKLEDEAARKAKQ-GKENLWKEN 707 Query: 113 APTEEEEESESEDSEDSGGEEEDAEEEEEEK----------EENESHKWSTGEEYIAVGD 162 EEEE+ + E + + ++ E + EEK EE + S Y A+ Sbjct: 708 LRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYP 767 Query: 163 FTAQQVGDLTFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 215 F A+ +++F G+I+ V EK + W+ +GN G P Y+E P SE E+ Sbjct: 768 FEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823 Score = 39.7 bits (91), Expect = 0.010 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%) Query: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 215 + IA+ D+ A +L+F KG+++ V+ K WW + G GL P Y++ ++ + Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1189 Query: 216 GQE 218 Q+ Sbjct: 1190 SQQ 1192 Score = 33.9 bits (76), Expect = 0.55 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%) Query: 159 AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 218 A+ +TA++ L F K +I+ V+E++ + WW + G G P++Y++ E +E Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 962 Query: 219 SSE 221 E Sbjct: 963 EPE 965 >gi|194294525 intersectin 2 isoform 2 [Homo sapiens] Length = 1249 Score = 57.4 bits (137), Expect = 5e-08 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%) Query: 131 GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 186 G E EE E ++ S +S GEEYIA+ +++ + GDLTF +GE +LV +K Sbjct: 956 GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013 Query: 187 DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235 DG W G+ P Y++P +E G S S + E T+ Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062 Score = 45.8 bits (107), Expect = 1e-04 Identities = 56/236 (23%), Positives = 101/236 (42%), Gaps = 25/236 (10%) Query: 2 LARRQRDPLQALRRRNQELKQQVDSL--------LSESQLKEALEP-NKRQHIYQRCIQL 52 L +R ++ L AL + ++DS + +S L+ L + +++ +L Sbjct: 591 LCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKEL 650 Query: 53 KQAIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVG 112 ++ + + AL++L K +RK E KL + A +EN+ + Sbjct: 651 RETYNTQQLALEQLYKIKRDK--LKEIERKRLELMQKKKLEDEAARKAKQ-GKENLWKEN 707 Query: 113 APTEEEEESESEDSEDSGGEEEDAEEEEEEK----------EENESHKWSTGEEYIAVGD 162 EEEE+ + E + + ++ E + EEK EE + S Y A+ Sbjct: 708 LRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYP 767 Query: 163 FTAQQVGDLTFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 215 F A+ +++F G+I+ V EK + W+ +GN G P Y+E P SE E+ Sbjct: 768 FEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823 Score = 39.7 bits (91), Expect = 0.010 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%) Query: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 215 + IA+ D+ A +L+F KG+++ V+ K WW + G GL P Y++ ++ + Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1189 Query: 216 GQE 218 Q+ Sbjct: 1190 SQQ 1192 Score = 33.9 bits (76), Expect = 0.55 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%) Query: 159 AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 218 A+ +TA++ L F K +I+ V+E++ + WW + G G P++Y++ E +E Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 962 Query: 219 SSE 221 E Sbjct: 963 EPE 965 >gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens] Length = 545 Score = 56.2 bits (134), Expect = 1e-07 Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 14/207 (6%) Query: 9 PLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSK 68 P Q +R Q+L+++ L E +EAL+ K + +Y++ Q+ + LS Sbjct: 340 PEQQRKRLQQQLEERSRELQKEVDQREALK--KMKDVYEKTPQMGDPASLEPQIAETLSN 397 Query: 69 ADE-SAPVANYNQ-RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDS 126 + V Y E E +L L A R AP + S S+D+ Sbjct: 398 IERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHA----RPPDPPASAPPDSSSNSASQDT 453 Query: 127 EDSGGEEEDAEEEE-----EEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLV 181 ++S E E ++ E E+ E S +A+ F G ++ +GE L + Sbjct: 454 KESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSL 513 Query: 182 IEK-KPDGWWIAKDAKGNEGLVPRTYL 207 +E+ K DGW + +G EG VP +YL Sbjct: 514 MEEDKGDGWTRVRRKEGGEGYVPTSYL 540 >gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform 3 [Homo sapiens] Length = 526 Score = 55.8 bits (133), Expect = 1e-07 Identities = 53/187 (28%), Positives = 76/187 (40%), Gaps = 23/187 (12%) Query: 84 EEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEK 143 EE LL L T S E+ + EEEE E E+ E+ G E++EEEEEE+ Sbjct: 2 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 61 Query: 144 EENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAK 196 EE E S EE + +A++V + + E +L+V E + D +D+ Sbjct: 62 EEEEEETGSNSEE---ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD-----RDSG 113 Query: 197 GNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAIS 256 +E E E EG S +E D E+KQ + A+Q S Sbjct: 114 ESE--------EAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRS 165 Query: 257 EAGIFCL 263 CL Sbjct: 166 VEEFQCL 172 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 55.1 bits (131), Expect = 2e-07 Identities = 50/161 (31%), Positives = 73/161 (45%), Gaps = 18/161 (11%) Query: 80 QRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEE 139 ++KE E + Q+++ E E G EEEEE E E E+ GEE + E E Sbjct: 711 EQKEREQGHQKERNQEMEEGGEEEHGEGEEEEG-DREEEEEKEGEGKEEGEGEEVEGERE 769 Query: 140 EEE---KEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAK 196 +EE K+E + K GEE G+ ++ T +GE EK+ G + + Sbjct: 770 KEEGERKKEERAGKEEKGEEEGDQGEGEEEE----TEGRGE-----EKEEGG-----EVE 815 Query: 197 GNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADG 237 G E + E EE EG+E EG EE+ E +E +G Sbjct: 816 GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG 856 Score = 50.4 bits (119), Expect = 6e-06 Identities = 44/132 (33%), Positives = 59/132 (44%), Gaps = 19/132 (14%) Query: 106 ENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTA 165 E E G EEE E E E+ E G EE + E EEE EE E GEE G+ Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE----GEEEEGEGEGEE 889 Query: 166 QQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSE 225 + G+ ++GE E + +G ++ +G EG EEEG+E EG E Sbjct: 890 EGEGEGEEEEGE----GEGEEEGEGEGEEEEG-EG----------KGEEEGEEGEGEGEE 934 Query: 226 EDVEAVDETADG 237 E+ E E +G Sbjct: 935 EEGEGEGEDGEG 946 Score = 46.6 bits (109), Expect = 8e-05 Identities = 41/124 (33%), Positives = 57/124 (45%), Gaps = 13/124 (10%) Query: 112 GAPTEEEEESESEDSEDSG--------GEEEDAEEEEEEKEENESHKW-STGEEYIAVGD 162 G EEE E E ED E G GEEE+ E E EE+ E E + GEE G+ Sbjct: 930 GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGE 989 Query: 163 FTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEE 222 ++ + ++GE E++ +G ++ EG V E EEEEG+E EE Sbjct: 990 GEEEEGEEEGEEEGE----GEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045 Query: 223 GSEE 226 +E Sbjct: 1046 REKE 1049 Score = 46.2 bits (108), Expect = 1e-04 Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 15/130 (11%) Query: 116 EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 175 EEE E E E+ E G EEE E EEE+ E E + GEE G+ ++ G++ + Sbjct: 967 EEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEE-GEGEGEEEEEGEV---E 1022 Query: 176 GEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235 GE+ + +G ++ +G E R +E EG+E+ EE+ E Sbjct: 1023 GEV-----EGEEGEGEGEEEEGEEEGEER------EKEGEGEENRRNREEEEEEEGKYQE 1071 Query: 236 DGAEVKQRTD 245 G E +R D Sbjct: 1072 TGEEENERQD 1081 Score = 44.7 bits (104), Expect = 3e-04 Identities = 45/169 (26%), Positives = 73/169 (43%), Gaps = 22/169 (13%) Query: 71 ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130 E V +++E E ++ ++ +G E + G EEE E E+ E+ G Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKG-------EEEGDQGEGEEEETEGRGEEKEE-G 811 Query: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW 190 GE E E EE + E E + GEE G+ ++ G+ ++GE + + +G Sbjct: 812 GEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE---EEEGEGEEEEGEG----KGEEEGEE 864 Query: 191 IAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 239 + +G EG E EEEEG+ EE E + E + +G E Sbjct: 865 GEGEEEGEEG-------EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906 Score = 44.7 bits (104), Expect = 3e-04 Identities = 40/131 (30%), Positives = 61/131 (46%), Gaps = 12/131 (9%) Query: 112 GAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ-QVGD 170 G EE + E+ E+ GEEE+ E EEEE E E GEE G+ + + G+ Sbjct: 816 GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE 875 Query: 171 LTFKKGEILLVIEKKPDGWWIAKDAKG---NEGLVPRTYLEPYSEEEEGQ-ESSEEGSEE 226 ++ E E++ +G ++ +G EG E EEEEG+ + EEG E Sbjct: 876 GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG-------EGEGEEEEGEGKGEEEGEEG 928 Query: 227 DVEAVDETADG 237 + E +E +G Sbjct: 929 EGEGEEEEGEG 939 Score = 44.7 bits (104), Expect = 3e-04 Identities = 45/133 (33%), Positives = 58/133 (43%), Gaps = 20/133 (15%) Query: 110 EVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVG 169 E G EEEE E E GEEE+ EEE EE+ E E GEE G+ + G Sbjct: 975 EEGEGEGEEEEGEGE------GEEEEGEEEGEEEGEGEEEGEGEGEEE-EEGEVEGEVEG 1027 Query: 170 DLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVE 229 + +GE E + +G K+ +G E R EEEE + E G EE Sbjct: 1028 EEGEGEGE---EEEGEEEGEEREKEGEGEENRRNRE-----EEEEEEGKYQETGEEE--- 1076 Query: 230 AVDETADGAEVKQ 242 +E DG E K+ Sbjct: 1077 --NERQDGEEYKK 1087 Score = 43.1 bits (100), Expect = 0.001 Identities = 42/130 (32%), Positives = 59/130 (45%), Gaps = 21/130 (16%) Query: 112 GAPTEEEEESESEDSEDSG-GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGD 170 G EE EE E E E+ G GE ED E E EE+E +W GEE G+ + G+ Sbjct: 919 GKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE----GEWE-GEEEEGEGEGEEEGEGE 973 Query: 171 LTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE-EGSEEDVE 229 +GE ++ +G ++ +G E EE EG+E E EG EE+ Sbjct: 974 GEEGEGE-----GEEEEGEGEGEEEEGE---------EEGEEEGEGEEEGEGEGEEEEEG 1019 Query: 230 AVDETADGAE 239 V+ +G E Sbjct: 1020 EVEGEVEGEE 1029 Score = 38.9 bits (89), Expect = 0.017 Identities = 52/219 (23%), Positives = 90/219 (41%), Gaps = 47/219 (21%) Query: 55 AIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQ---GLAVTISR------ 105 A D N +++ V + RKE+ L D LT + + G A ++ Sbjct: 593 AEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPE 652 Query: 106 ---ENITEVGAPTEE--EEESESEDSEDSG---------GEEEDAE---------EEEEE 142 + E G+ E ++E + +D G GE+E AE EE+E+ Sbjct: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ 712 Query: 143 KEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLV 202 KE + H+ +E G+ ++ G+ ++G+ EK+ +G ++ +G E Sbjct: 713 KEREQGHQKERNQEMEEGGE---EEHGEGEEEEGDREEEEEKEGEG---KEEGEGEE--- 763 Query: 203 PRTYLEPYSEEEEGQESSEE--GSEEDVEAVDETADGAE 239 +E E+EEG+ EE G EE E + +G E Sbjct: 764 ----VEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798 Score = 33.1 bits (74), Expect = 0.94 Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 1/53 (1%) Query: 106 ENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEE-NESHKWSTGEEY 157 E E G EE E E E E+ EE+ EEE + +E E ++ GEEY Sbjct: 1033 EGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEY 1085 Score = 32.7 bits (73), Expect = 1.2 Identities = 39/147 (26%), Positives = 64/147 (43%), Gaps = 17/147 (11%) Query: 100 AVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIA 159 A TI + EV P EE+ +EDS+ +G EE++ E EE + + K T I Sbjct: 573 ATTIEAFSDEEVEIP---EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKT---EIL 626 Query: 160 VGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219 D T + +++ K + + E P+G +G+ G E + +EE + Sbjct: 627 SDDLTDK--AEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSG------AEHWQDEEREKGE 678 Query: 220 SEEG---SEEDVEAVDETADGAEVKQR 243 ++G E E E A+ E K+R Sbjct: 679 KDKGRGEMERPGEGEKELAEKEEWKKR 705 >gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a [Homo sapiens] Length = 304 Score = 54.7 bits (130), Expect = 3e-07 Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%) Query: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214 EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y Sbjct: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194 Query: 215 EGQESSEEGSEE 226 + G++E Sbjct: 195 ASVSALIGGNQE 206 >gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b [Homo sapiens] Length = 204 Score = 53.9 bits (128), Expect = 5e-07 Identities = 24/56 (42%), Positives = 36/56 (64%), Gaps = 1/56 (1%) Query: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210 EY+ A+ DF DL FKKG+IL + +K + WW A+D++G G++P Y+E Y Sbjct: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190 >gi|109689723 abl interactor 2 [Homo sapiens] Length = 475 Score = 53.9 bits (128), Expect = 5e-07 Identities = 39/120 (32%), Positives = 58/120 (48%), Gaps = 13/120 (10%) Query: 105 RENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEE------NESHKWSTG---E 155 +ENI++ P EE ++S ED EEEE E E W+ E Sbjct: 357 QENISDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLE 416 Query: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEP---YSE 212 + +A+ D+T + +L+F++G I+ VI+K DGW+ G GL P Y+E YSE Sbjct: 417 KVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGV-MNGVTGLFPGNYVESIMHYSE 475 >gi|84043963 eukaryotic translation initiation factor 5B [Homo sapiens] Length = 1220 Score = 53.9 bits (128), Expect = 5e-07 Identities = 75/314 (23%), Positives = 119/314 (37%), Gaps = 87/314 (27%) Query: 15 RRNQELKQQVDSLLSESQL--KEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKADES 72 R+ Q+ K++ + L E +L K E R + +Q + +K++L K Sbjct: 389 RKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPK------K 442 Query: 73 APVANYNQRKEEEHTLLDKLTQQLQGLAVTISRE-----NITEVGAPTEEE-----EESE 122 P+ +RK K+ QQL+ V+ S E + E G P +EE E E Sbjct: 443 RPIYEDKKRK--------KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEE 494 Query: 123 SEDSEDSG-----------------------------GEEEDAEEEEEEKEENESHKWST 153 ED+ED+G EEE+ EEEEEE EE+E + Sbjct: 495 EEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEE 554 Query: 154 GEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEE 213 GE + GD ++V D + + ++KKP Sbjct: 555 GESEGSEGDEEDEKVSD----EKDSGKTLDKKP--------------------------S 584 Query: 214 EEGQESSEEGSEEDVEAVDETADGAE--VKQRTDPHWSAVQKAISEAGIFCLVNHVSFCY 271 +E SE S++D + D A+ +++R H V A I C++ HV Sbjct: 585 KEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGK 644 Query: 272 LIVLMRNRMETVED 285 +L + R V+D Sbjct: 645 TKILDKLRHTHVQD 658 Score = 34.7 bits (78), Expect = 0.32 Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 12/103 (11%) Query: 57 DENKNALQKLSKADE------SAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE 110 DE K L+KL + +E +QRK EE T+ K+T + S E + Sbjct: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTG--VIPASEE---K 298 Query: 111 VGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWST 153 PT E+++E D + +++ E+EE+EKE+ + +T Sbjct: 299 AETPTAAEDDNEG-DKKKKDKKKKKGEKEEKEKEKKKGPSKAT 340 Score = 30.0 bits (66), Expect = 8.0 Identities = 31/162 (19%), Positives = 73/162 (45%), Gaps = 14/162 (8%) Query: 2 LARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQR-----CIQLKQAI 56 +A+++ + + R++ E K ++ L + +L+ + +Q QR ++ K + Sbjct: 228 VAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTV 287 Query: 57 D------ENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE 110 D + A + D++ +K+++ +K ++ +G + + + E Sbjct: 288 DTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKA-MQE 346 Query: 111 VGAPTEEEEESESEDSED--SGGEEEDAEEEEEEKEENESHK 150 A +EEEE + + E+ EE +A+ +EEE+ E E + Sbjct: 347 ALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRE 388 >gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like [Homo sapiens] Length = 303 Score = 53.1 bits (126), Expect = 9e-07 Identities = 24/54 (44%), Positives = 34/54 (62%), Gaps = 1/54 (1%) Query: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 208 EY+ + DF DL FKKGEIL++IEK + WW A++ G G++P Y+E Sbjct: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179 >gi|21735415 centromere protein B [Homo sapiens] Length = 599 Score = 53.1 bits (126), Expect = 9e-07 Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 8/133 (6%) Query: 116 EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 175 EEEEE E E+ E+ GEEE+ E EEEE+E E + EE GD + + + + Sbjct: 407 EEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEES 466 Query: 176 GEILLVIEKKPDGWWIAKDAKGNEGLVPRT------YLE--PYSEEEEGQESSEEGSEED 227 L E G A + G G +LE S+ + +E EE +ED Sbjct: 467 SSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDED 526 Query: 228 VEAVDETADGAEV 240 + D+ DG EV Sbjct: 527 EDDDDDEEDGDEV 539 Score = 32.3 bits (72), Expect = 1.6 Identities = 35/136 (25%), Positives = 56/136 (41%), Gaps = 22/136 (16%) Query: 92 LTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKW 151 LT+ L +A +++ A E ++ + + + EEEEEE+EE E + Sbjct: 361 LTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEE- 419 Query: 152 STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYS 211 GEE G+ ++ G+ GE L E+ + + D Sbjct: 420 GEGEEEEEEGEEEEEEGGE-----GEELGEEEEVEEEGDVDSD----------------E 458 Query: 212 EEEEGQESSEEGSEED 227 EEEE +ESS EG E + Sbjct: 459 EEEEDEESSSEGLEAE 474 Score = 32.0 bits (71), Expect = 2.1 Identities = 13/45 (28%), Positives = 25/45 (55%) Query: 116 EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAV 160 + + +SE ED E+ E+ED +++EE+ +E + Y A+ Sbjct: 509 DSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAM 553 Score = 31.6 bits (70), Expect = 2.7 Identities = 29/147 (19%), Positives = 66/147 (44%), Gaps = 17/147 (11%) Query: 26 SLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNA-----LQKLSKADESAPVANYNQ 80 SL SE + +E E + + + + ++ +E + L + + +E V + + Sbjct: 400 SLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEE 459 Query: 81 RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTE------------EEEESESEDSED 128 +E+E + + L + V + + GA E E+ +S+SE+ +D Sbjct: 460 EEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDD 519 Query: 129 SGGEEEDAEEEEEEKEENESHKWSTGE 155 ++ED +++++E++ +E S GE Sbjct: 520 EEEDDEDEDDDDDEEDGDEVPVPSFGE 546 >gi|17975763 myelin transcription factor 1 [Homo sapiens] Length = 1121 Score = 53.1 bits (126), Expect = 9e-07 Identities = 43/149 (28%), Positives = 64/149 (42%), Gaps = 5/149 (3%) Query: 20 LKQQVDSLLSESQLKEALEPNKR-QHIYQRCIQLKQAIDENKNALQKLSKADESAPVANY 78 L Q + L E L +A +P H+ Q + + + K + A+E V Sbjct: 171 LGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTE 230 Query: 79 NQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEE 138 + +L D +++ +S E E EEEEE E E+ E+ EEE+ EE Sbjct: 231 RSQDLCPQSLEDAASEESSKQKGILSHEEEDE----EEEEEEEEEEEDEEEEEEEEEEEE 286 Query: 139 EEEEKEENESHKWSTGEEYIAVGDFTAQQ 167 EEEE+EE E + EE A D Q+ Sbjct: 287 EEEEEEEEEEEEEEEEEEEEAAPDVIFQE 315 Score = 33.5 bits (75), Expect = 0.72 Identities = 46/215 (21%), Positives = 76/215 (35%), Gaps = 56/215 (26%) Query: 119 EESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEI 178 E++ SE+S G EE+EEE+EE E + EE Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEE---------------------- 278 Query: 179 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 238 E EEEE +E EE EE+ E +E Sbjct: 279 -----------------------------EEEEEEEEEEEEEEEEEEEEEEEEEEEEAAP 309 Query: 239 EVKQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGF----R 294 +V + D ++ QKA G + +IV +R+ + EDT+ ++ Sbjct: 310 DVIFQEDTSHTSAQKAPELRGPESPSPKPEYS-VIVEVRSDDDKDEDTHSRKSTVTDESE 368 Query: 295 AWNVQSRGRIFLVSKPVLQQINTVDVLTTMGAIPA 329 ++ +RG + L+ + + + V + G PA Sbjct: 369 MQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPA 403 >gi|55749544 SH3 multiple domains 1 [Homo sapiens] Length = 1105 Score = 52.0 bits (123), Expect = 2e-06 Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%) Query: 155 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY--SE 212 E+Y+ V ++ Q+ +L+ + GE++ VIEK GWW ++ +G VP TYLE + Sbjct: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSE-EQGWVPATYLEAQNGTR 227 Query: 213 EEEGQESSEEGSEE 226 ++ +S+ G EE Sbjct: 228 DDSDINTSKTGEEE 241 Score = 48.5 bits (114), Expect = 2e-05 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%) Query: 137 EEEEEEKEENESHKWSTGEE--YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKD 194 E + +++++ + TGEE Y+ V +T+Q ++ F+KG + VI K +GWW + Sbjct: 221 EAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIR- 279 Query: 195 AKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETAD 236 G EG P +YL+ ++ ++ + G E + + E ++ Sbjct: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISN 321 Score = 38.1 bits (87), Expect = 0.029 Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 7/134 (5%) Query: 81 RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEE 140 R+ E T D L + + + +R E E S+ DS + Sbjct: 970 RRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSP 1029 Query: 141 EEKEENESHKW---STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKD 194 + E ++ + + Y+++ D+ + F++G + V+E+ P+GWW I Sbjct: 1030 VRPKPIEKSQFIHNNLKDVYVSIADYEGDEE-TAGFQEGVSMEVLERNPNGWWYCQILDG 1088 Query: 195 AKGNEGLVPRTYLE 208 K +G VP YLE Sbjct: 1089 VKPFKGWVPSNYLE 1102 Score = 34.7 bits (78), Expect = 0.32 Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%) Query: 93 TQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENE----- 147 +Q + + ++ R + G + S+SEDSE +A E + ++ Sbjct: 739 SQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLP 798 Query: 148 --------SHKWS-TGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGN 198 +W Y+ + Q +++F G + V+EK+ GWW + + Sbjct: 799 ATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE-L 857 Query: 199 EGLVPRTYLEPYSEEEEGQESSEE 222 EG P YL E E+ S +E Sbjct: 858 EGWAPSHYL-VLDENEQPDPSGKE 880 Score = 33.9 bits (76), Expect = 0.55 Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 1/53 (1%) Query: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 208 EY + +F + ++F+ G+ VI+K GWW + + EG P +Y++ Sbjct: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGE-KEGWAPASYID 475 >gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens] Length = 551 Score = 50.8 bits (120), Expect = 4e-06 Identities = 45/199 (22%), Positives = 84/199 (42%), Gaps = 10/199 (5%) Query: 15 RRNQELKQQVDSL----LSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKAD 70 +R ++L+Q++D L ES K+AL NK + +Y++ Q+ + ++ D Sbjct: 344 QRRKKLQQRIDELNRELQKESDQKDAL--NKMKDVYEKNPQMGDPGSLQPKLAETMNNID 401 Query: 71 ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130 + N+ E ++ T + ++ G + E ++ + E G Sbjct: 402 RLRMEIHKNEAWLSE---VEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRG 458 Query: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK-KPDGW 189 ++ E + E + A+ F G L K+GE+L +IE+ K DGW Sbjct: 459 PPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGW 518 Query: 190 WIAKDAKGNEGLVPRTYLE 208 A+ G EG VP +Y++ Sbjct: 519 TRARRQNGEEGYVPTSYID 537 >gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens] Length = 547 Score = 50.8 bits (120), Expect = 4e-06 Identities = 45/199 (22%), Positives = 84/199 (42%), Gaps = 10/199 (5%) Query: 15 RRNQELKQQVDSL----LSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKAD 70 +R ++L+Q++D L ES K+AL NK + +Y++ Q+ + ++ D Sbjct: 344 QRRKKLQQRIDELNRELQKESDQKDAL--NKMKDVYEKNPQMGDPGSLQPKLAETMNNID 401 Query: 71 ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130 + N+ E ++ T + ++ G + E ++ + E G Sbjct: 402 RLRMEIHKNEAWLSE---VEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRG 458 Query: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK-KPDGW 189 ++ E + E + A+ F G L K+GE+L +IE+ K DGW Sbjct: 459 PPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGW 518 Query: 190 WIAKDAKGNEGLVPRTYLE 208 A+ G EG VP +Y++ Sbjct: 519 TRARRQNGEEGYVPTSYID 537 >gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] Length = 4374 Score = 50.8 bits (120), Expect = 4e-06 Identities = 25/74 (33%), Positives = 45/74 (60%), Gaps = 1/74 (1%) Query: 75 VANYNQRKEEEHTLLDKLTQQL-QGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEE 133 V+ + + +E L+D+ L Q + +RE+ + P +EEE ++ EDS S +E Sbjct: 2369 VSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDE 2428 Query: 134 EDAEEEEEEKEENE 147 +D+++EEEE+EE+E Sbjct: 2429 DDSQDEEEEEEEDE 2442 Score = 35.4 bits (80), Expect = 0.19 Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 9/62 (14%) Query: 83 EEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEE 142 EEEHT + + S E+ + EEEEE E +D ED GEE D +++++ Sbjct: 2412 EEEHTQEEDSSG---------SNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDG 2462 Query: 143 KE 144 E Sbjct: 2463 SE 2464 >gi|58761548 tau tubulin kinase 1 [Homo sapiens] Length = 1321 Score = 50.8 bits (120), Expect = 4e-06 Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 16/114 (14%) Query: 116 EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 175 EEEEE E E+ E+ EEE+ EEEEEE+EE E + +A+G+ + G + + Sbjct: 734 EEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSG--SSSE 791 Query: 176 GEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVE 229 G E+ D + EG P T L +E G+ S +G E E Sbjct: 792 GS-----ERSTD--------RSQEG-APSTLLADDQKESRGRASMADGDLEPEE 831 >gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a [Homo sapiens] Length = 1071 Score = 50.8 bits (120), Expect = 4e-06 Identities = 47/186 (25%), Positives = 75/186 (40%), Gaps = 25/186 (13%) Query: 101 VTISRENI----TEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEE--KEENESHKWSTG 154 + I ENI E+ P S + + GE E+ ++ E + S Sbjct: 671 IIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEP 730 Query: 155 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214 E IA D+ + +L+FKKG LL+ ++ D WW + G +GL+P Y+ E+ Sbjct: 731 IEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRH-NGIDGLIPHQYIVVQDTED 789 Query: 215 EGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFC-LVNHVSFCYLI 273 E S SE +E + E + +K + AG C HV+ YL Sbjct: 790 GVVERSSPKSE--IEVISEPPE---------------EKVTARAGASCPSGGHVADIYLA 832 Query: 274 VLMRNR 279 + + R Sbjct: 833 NINKQR 838 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.133 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,718,179 Number of Sequences: 37866 Number of extensions: 1409011 Number of successful extensions: 32120 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 619 Number of HSP's successfully gapped in prelim test: 586 Number of HSP's that attempted gapping in prelim test: 13226 Number of HSP's gapped (non-prelim): 8964 length of query: 733 length of database: 18,247,518 effective HSP length: 110 effective length of query: 623 effective length of database: 14,082,258 effective search space: 8773246734 effective search space used: 8773246734 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.