Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 46049114
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
(1780 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 3443 0.0
gi|5032013 kinesin family member 20A [Homo sapiens] 405 e-112
gi|6754472 kinesin family member 23 isoform 2 [Homo sapiens] 254 7e-67
gi|20143967 kinesin family member 23 isoform 1 [Homo sapiens] 254 7e-67
gi|71061468 centromere protein E [Homo sapiens] 250 1e-65
gi|9910266 kinesin family member 15 [Homo sapiens] 227 9e-59
gi|38569484 kinesin family member 21A [Homo sapiens] 177 6e-44
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens] 174 5e-43
gi|116686122 kinesin family member 4 [Homo sapiens] 173 1e-42
gi|150010604 kinesin family member 4B [Homo sapiens] 164 7e-40
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 163 1e-39
gi|4758650 kinesin family member 5C [Homo sapiens] 157 7e-38
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 154 6e-37
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 152 3e-36
gi|4506751 restin isoform a [Homo sapiens] 150 1e-35
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 150 1e-35
gi|4758648 kinesin family member 5B [Homo sapiens] 148 5e-35
gi|13699824 kinesin family member 11 [Homo sapiens] 146 2e-34
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 145 4e-34
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 145 4e-34
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 145 4e-34
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 145 4e-34
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 145 4e-34
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 145 4e-34
gi|38044112 restin isoform b [Homo sapiens] 144 6e-34
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 144 8e-34
gi|46852174 kinesin family member 3A [Homo sapiens] 144 1e-33
gi|4758646 kinesin family member 3B [Homo sapiens] 143 1e-33
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 143 1e-33
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 142 3e-33
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 3443 bits (8927), Expect = 0.0
Identities = 1780/1780 (100%), Positives = 1780/1780 (100%)
Query: 1 MESNFNQEGVPRPSYVFSADPIARPSEINFDGIKLDLSHEFSLVAPNTEANSFESKDYLQ 60
MESNFNQEGVPRPSYVFSADPIARPSEINFDGIKLDLSHEFSLVAPNTEANSFESKDYLQ
Sbjct: 1 MESNFNQEGVPRPSYVFSADPIARPSEINFDGIKLDLSHEFSLVAPNTEANSFESKDYLQ 60
Query: 61 VCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFG 120
VCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFG
Sbjct: 61 VCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFG 120
Query: 121 PATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLF 180
PATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLF
Sbjct: 121 PATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLF 180
Query: 181 DSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSL 240
DSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSL
Sbjct: 181 DSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSL 240
Query: 241 TNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKML 300
TNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKML
Sbjct: 241 TNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKML 300
Query: 301 RLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKIL 360
RLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKIL
Sbjct: 301 RLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKIL 360
Query: 361 QIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNS 420
QIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNS
Sbjct: 361 QIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNS 420
Query: 421 EKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC 480
EKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC
Sbjct: 421 EKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC 480
Query: 481 VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELE 540
VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELE
Sbjct: 481 VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELE 540
Query: 541 NAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFK 600
NAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFK
Sbjct: 541 NAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFK 600
Query: 601 IREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDIC 660
IREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDIC
Sbjct: 601 IREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDIC 660
Query: 661 ATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKII 720
ATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKII
Sbjct: 661 ATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKII 720
Query: 721 TQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVP 780
TQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVP
Sbjct: 721 TQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVP 780
Query: 781 KDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVL 840
KDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVL
Sbjct: 781 KDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVL 840
Query: 841 QENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNY 900
QENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNY
Sbjct: 841 QENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNY 900
Query: 901 DIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQ 960
DIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQ
Sbjct: 901 DIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQ 960
Query: 961 ISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAI 1020
ISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAI
Sbjct: 961 ISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAI 1020
Query: 1021 WEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETL 1080
WEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETL
Sbjct: 1021 WEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETL 1080
Query: 1081 IQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHS 1140
IQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHS
Sbjct: 1081 IQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHS 1140
Query: 1141 AKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK 1200
AKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK
Sbjct: 1141 AKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK 1200
Query: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK 1260
HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK
Sbjct: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK 1260
Query: 1261 QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQY 1320
QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQY
Sbjct: 1261 QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQY 1320
Query: 1321 ERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLE 1380
ERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLE
Sbjct: 1321 ERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLE 1380
Query: 1381 TKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIR 1440
TKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIR
Sbjct: 1381 TKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIR 1440
Query: 1441 NKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSN 1500
NKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSN
Sbjct: 1441 NKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSN 1500
Query: 1501 VQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGS 1560
VQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGS
Sbjct: 1501 VQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGS 1560
Query: 1561 VVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNE 1620
VVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNE
Sbjct: 1561 VVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNE 1620
Query: 1621 MEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVN 1680
MEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVN
Sbjct: 1621 MEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVN 1680
Query: 1681 LATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKL 1740
LATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKL
Sbjct: 1681 LATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKL 1740
Query: 1741 YTSEISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
YTSEISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK
Sbjct: 1741 YTSEISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
>gi|5032013 kinesin family member 20A [Homo sapiens]
Length = 890
Score = 405 bits (1040), Expect = e-112
Identities = 271/722 (37%), Positives = 408/722 (56%), Gaps = 98/722 (13%)
Query: 33 IKLDLSHEFSLVAPNTEAN----SFESKDYLQVCLRIRPFTQSEKEL-ESEGCVHILDSQ 87
++ +L + S+V+ + E S +S + ++V LR+RP SE E E +GCV I + +
Sbjct: 35 VRKNLLSDCSVVSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVE 94
Query: 88 TVVLKEPQCILG-RLSEKSSGQMAQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSR 146
T+VL+ P+ + +E+ GQ +F+FS++FGP Q FF + + VKD+LKGQ+
Sbjct: 95 TLVLQAPKDSFALKSNERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNW 154
Query: 147 LIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSS 206
LI+TYG+TNSGKT+T QGT ++ GILPR+L ++F+SLQ +L+ +LKP S E + L S
Sbjct: 155 LIYTYGVTNSGKTHTIQGTIKDGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDS 214
Query: 207 EQEKEEIASKSALLR---QIKEV----------------TVHNDSDDTLYGSLTNSLNIS 247
+Q ++E K +LL Q +E+ + DS S++ + S
Sbjct: 215 KQIRQEEMKKLSLLNGGLQEEELSTSLKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSS 274
Query: 248 EFEESIKDYEQ---ANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQ 304
+ +E+ + Q A L + +I+FS+W+SFFEIYNE +YDL P S + +KR+ LRL +
Sbjct: 275 QLDETSHRWAQPDTAPLPVPANIRFSIWISFFEIYNELLYDLLEPPSQQ-RKRQTLRLCE 333
Query: 305 DVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIED 364
D G ++KDL WI V D++EA++LLK+G K+QS A T LN SSRSHSIF+++IL ++
Sbjct: 334 DQNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTHLNQNSSRSHSIFSIRILHLQ- 392
Query: 365 SEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSK 424
E V ++SELSLCDLAGSER K Q GERL+E GNINTSL TLG+CI L+ +++++
Sbjct: 393 GEGDIVPKISELSLCDLAGSER-CKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQQNR 451
Query: 425 FQQH-VPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPD 483
+Q+ VPFR+SKLT FQ FF G+G+ CMIVN++ C YDETL+V KFSAIA ++
Sbjct: 452 SKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSAIASQLVHAP 511
Query: 484 TLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAE 543
+ L +K E+SL+ + LE
Sbjct: 512 PMQLGFPSLHSFIK-------------------------EHSLQ-------VSPSLEKGA 539
Query: 544 ETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIRE 603
+ LD+D+ EN+A IS K +LL ++E +K L+ E++EKL LE +R+
Sbjct: 540 KADTG----LDDDI-----ENEADISMYGKEELLQVVEAMKTLLLKERQEKLQLEMHLRD 590
Query: 604 EVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLV-----GKCDTREEAAKD 658
E+ E + QRE E L ++E+LEE E +L I K+ + + R+E ++
Sbjct: 591 EICNEMVEQMQQREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEE 650
Query: 659 ICATKVETEE--------------------ATACLELKFNQIKAELAKTKGELIKTKEEL 698
+ A E + A + + ++KA+L + K EL T EEL
Sbjct: 651 LEALLQEARQQSVAHQQSGSELALRRSQRLAASASTQQLQEVKAKLQQCKAELNSTTEEL 710
Query: 699 KK 700
K
Sbjct: 711 HK 712
Score = 47.0 bits (110), Expect = 2e-04
Identities = 107/554 (19%), Positives = 218/554 (39%), Gaps = 104/554 (18%)
Query: 867 ELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSN 926
E+ ++++ E ++K TL Q + Y + +HVQ + E+ K++K+
Sbjct: 307 EIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDA---EEAWKLLKVGR 363
Query: 927 EIET-------ATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNL------RDLS 973
+ ++ S ++++ I+++H + + D V +IS + L +L +D
Sbjct: 364 KNQSFASTHLNQNSSRSHSIFSIRILHLQGEG----DIVPKISELSLCDLAGSERCKDQK 419
Query: 974 NGS---EEDNLPNTQLDLLGNDYLVSKQVKEYRIQE---PNRENSFHSSIEAI------- 1020
+G E N+ NT L LG +Q ++ R ++ P R++ +
Sbjct: 420 SGERLKEAGNI-NTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRS 478
Query: 1021 ------------WEECKEIVKASSKKSHQIEELEQQI--EKLQAEVKGYKDENNRLKEKE 1066
++E + K S+ S + Q+ L + +K + + + EK
Sbjct: 479 CMIVNVNPCASTYDETLHVAKFSAIASQLVHAPPMQLGFPSLHSFIKEHSLQVSPSLEKG 538
Query: 1067 HKNQ---DDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKI 1123
K DD ++ + + KEEL + + + + K L + C
Sbjct: 539 AKADTGLDDDIENEADISMYGKEELLQVVEAMKTLLLKERQEKLQLEMHLRDEIC----- 593
Query: 1124 KELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKEL 1183
E+ ++ ++ CS ++++LE+ E L +E L +
Sbjct: 594 NEMVEQMQQREQWCSEHLDTQKELLEE-----MYEEKLNILKESLTSFYQ---------- 638
Query: 1184 KLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKL------KEELSASSARTQNLKAD 1237
EEI + +++++ LLQ ++ ++Q +L + SAS+ + Q +KA
Sbjct: 639 ---EEIQERDEKIEELEALLQEARQQSVAHQQSGSELALRRSQRLAASASTQQLQEVKAK 695
Query: 1238 LQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMK 1297
LQ+ + + E+L +K ++ D DK +L+
Sbjct: 696 LQQCKAELNSTTEELHKYQKMLEPPPSAKPFTIDVDK------------------KLEEG 737
Query: 1298 QRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEA 1357
Q+ I+ L+ +L QK+ E++Q ERAC K +R L + ++QDQ L
Sbjct: 738 QKNIRLLRTEL--QKLGESLQSAERACCHSTGAGK----LRQALTTCDDILIKQDQTLAE 791
Query: 1358 KLEEVERLATELEK 1371
+ + +L K
Sbjct: 792 LQNNMVLVKLDLRK 805
Score = 39.7 bits (91), Expect = 0.026
Identities = 37/172 (21%), Positives = 91/172 (52%), Gaps = 18/172 (10%)
Query: 1262 VQKEVSV-MRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQY 1320
++ E + M +++LL++ +E K +E K + L++++ N+ VE+ +QQ
Sbjct: 549 IENEADISMYGKEELLQV----VEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQ-MQQR 603
Query: 1321 ERACKD-LNVKEKIIEDM---RMTLEEQEQTQVEQDQVLE--AKLEEVERLATELEK--- 1371
E+ C + L+ +++++E+M ++ + ++ T Q+++ E K+EE+E L E +
Sbjct: 604 EQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQEARQQSV 663
Query: 1372 -WKEKCNDLETKNNQR--SNKEHENNTDVLGKLTNLQDELQESEQKYNADRK 1420
++ ++L + +QR ++ + +V KL + EL + ++ + +K
Sbjct: 664 AHQQSGSELALRRSQRLAASASTQQLQEVKAKLQQCKAELNSTTEELHKYQK 715
>gi|6754472 kinesin family member 23 isoform 2 [Homo sapiens]
Length = 856
Score = 254 bits (648), Expect = 7e-67
Identities = 203/692 (29%), Positives = 362/692 (52%), Gaps = 71/692 (10%)
Query: 56 KDYLQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSF 115
KD + V R+RP ++E C+ ++++ TV L P+ G ++ ++SF
Sbjct: 23 KDPVGVYCRVRPLGFPDQEC----CIEVINNTTVQLHTPE---GYRLNRNGDYKETQYSF 75
Query: 116 SKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRT 175
+VFG TTQKE F V DL+ G++ L+FTYG+T SGKT+T G+ G+LPR
Sbjct: 76 KQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGSPGEGGLLPRC 135
Query: 176 LNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASK-SALLRQIKEVTVHNDSDD 234
L+++F+S+ +++ Y+ S+++ +I + ALL + K + N
Sbjct: 136 LDMIFNSIGS----------FQAKRYVFKSNDRNSMDIQCEVDALLERQKREAMPNPKTS 185
Query: 235 TLYGSLTNSLNISEFEE--SIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDL-----F 287
+ + EF + +++++ +A +S+ + V+VS+ EIYN YIYDL F
Sbjct: 186 SSKRQVD-----PEFADMITVQEFCKAEEVDEDSV-YGVFVSYIEIYNNYIYDLLEEVPF 239
Query: 288 VPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNA 347
P+ K + K+LR +D ++ ++V ++EA+ + G K + +A T LN
Sbjct: 240 DPIKPKPPQSKLLR--EDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRE 297
Query: 348 SSRSHSIFTVKILQIE-DSEMSRVIR------VSELSLCDLAGSERTMKTQNEGERLRET 400
SSRSHS+F +K++Q D++ V++ +S+LSL DLAGSERT +T+ EG RLRE
Sbjct: 298 SSRSHSVFNIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTRAEGNRLREA 357
Query: 401 GNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCY 460
GNIN SL+TL C++VL+ ++ + VP+R+SKLTH F+++F+G+GK+ MIV ++
Sbjct: 358 GNINQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKA 417
Query: 461 LAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATI 520
Y+E L V++F+ + Q+V V ++ + L + + + +V +
Sbjct: 418 EDYEENLQVMRFAEVTQEVEVARPVDKAICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSF 477
Query: 521 SWENSLE--DLMEDEDLVEELENAEETQNVETKLLDE-----DLDKTL--EENKAFISHE 571
S E D+ +++ L +E E+ N+ ++DE + K L E + A +S E
Sbjct: 478 PPLPSCEILDINDEQTLPRLIEALEKRHNLRQMMIDEFNKQSNAFKALLQEFDNAVLSKE 537
Query: 572 --------EKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKET 623
EK K +I K ++ +K+ TLE+KI E+ ++ T + + + + ++
Sbjct: 538 NHMQGKLNEKEK---MISGQKLEIERLEKKNKTLEYKI--EILEKTTTIYEEDKRNLQQE 592
Query: 624 LLQEREILEE--NAERRL-AIFKDLVGKCDTR--EEAAKDICATKVETEEATACLELKFN 678
L + + L+ + +RRL A + +V + + +E + + A ++E + + K
Sbjct: 593 LETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQNKLWVKDEKLK 652
Query: 679 QIKAELAKTKGELIKTKEELKKRENESDSLIQ 710
Q+KA + + K E K E RE + + + Q
Sbjct: 653 QLKAIVTEPKTE----KPERPSRERDREKVTQ 680
Score = 42.0 bits (97), Expect = 0.005
Identities = 50/202 (24%), Positives = 89/202 (44%), Gaps = 21/202 (10%)
Query: 1265 EVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERAC 1324
E+ + DE L R+ I LEK+ N +D + K L Q+ + A+ E
Sbjct: 484 EILDINDEQTLPRL-IEALEKRHNLRQMMIDEFNKQSNAFKALL--QEFDNAVLSKENHM 540
Query: 1325 KD-LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKC-NDLETK 1382
+ LN KEK+I ++ +E E+ +++ LE K+E +E+ T E+ K +LET+
Sbjct: 541 QGKLNEKEKMISGQKLEIERLEK----KNKTLEYKIEILEKTTTIYEEDKRNLQQELETQ 596
Query: 1383 NNQRSNKEHENNTDVLGKLTNLQDEL-----QESEQKYNA-----DRKKWL-EEKMMLIT 1431
NQ+ ++ + + +L + E +E E++ A K W+ +EK+ +
Sbjct: 597 -NQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQNKLWVKDEKLKQLK 655
Query: 1432 QAKEAENIRNKEMKKYAEDRER 1453
E DRE+
Sbjct: 656 AIVTEPKTEKPERPSRERDREK 677
Score = 38.1 bits (87), Expect = 0.077
Identities = 47/196 (23%), Positives = 97/196 (49%), Gaps = 25/196 (12%)
Query: 999 VKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDE 1058
+++ I E N++++ + +A+ +E V SK++H +L ++ EK+ + G K E
Sbjct: 507 LRQMMIDEFNKQSN---AFKALLQEFDNAVL--SKENHMQGKLNEK-EKM---ISGQKLE 557
Query: 1059 NNRLKEKEHKNQD---DLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQG 1115
RL EK++K + ++L++ T+ ++ K LQ++ T + ++Q KR L QG
Sbjct: 558 IERL-EKKNKTLEYKIEILEKTTTIYEEDKRNLQQELETQNQKLQRQFSDKRRLEARLQG 616
Query: 1116 VTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 1175
+ ET ++ +K EC +Q LE ++ + + LK+ + + + K
Sbjct: 617 MV--------TETTMKWEK-ECERRVAAKQ--LEMQNKLWVKDEKLKQLKAIVTEP-KTE 664
Query: 1176 KDLNVKELKLKEEITQ 1191
K + +E++TQ
Sbjct: 665 KPERPSRERDREKVTQ 680
Score = 32.3 bits (72), Expect = 4.2
Identities = 33/158 (20%), Positives = 75/158 (47%), Gaps = 9/158 (5%)
Query: 1151 ESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK-HLLQ----L 1205
++++ + + + + H+Q + N K+ + KL+ E + N + K +L+ +
Sbjct: 523 KALLQEFDNAVLSKENHMQGKL-NEKEKMISGQKLEIERLEKKNKTLEYKIEILEKTTTI 581
Query: 1206 KEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKE 1265
EE++ +QE E ++L + + L+A LQ + EK + + KQ++ +
Sbjct: 582 YEEDKRNLQQELETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQ 641
Query: 1266 VSVMRDEDKLLRIKINELE---KKKNQCSQELDMKQRT 1300
+ ++KL ++K E +K + S+E D ++ T
Sbjct: 642 NKLWVKDEKLKQLKAIVTEPKTEKPERPSRERDREKVT 679
>gi|20143967 kinesin family member 23 isoform 1 [Homo sapiens]
Length = 960
Score = 254 bits (648), Expect = 7e-67
Identities = 203/692 (29%), Positives = 362/692 (52%), Gaps = 71/692 (10%)
Query: 56 KDYLQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSF 115
KD + V R+RP ++E C+ ++++ TV L P+ G ++ ++SF
Sbjct: 23 KDPVGVYCRVRPLGFPDQEC----CIEVINNTTVQLHTPE---GYRLNRNGDYKETQYSF 75
Query: 116 SKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRT 175
+VFG TTQKE F V DL+ G++ L+FTYG+T SGKT+T G+ G+LPR
Sbjct: 76 KQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGSPGEGGLLPRC 135
Query: 176 LNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASK-SALLRQIKEVTVHNDSDD 234
L+++F+S+ +++ Y+ S+++ +I + ALL + K + N
Sbjct: 136 LDMIFNSIGS----------FQAKRYVFKSNDRNSMDIQCEVDALLERQKREAMPNPKTS 185
Query: 235 TLYGSLTNSLNISEFEE--SIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDL-----F 287
+ + EF + +++++ +A +S+ + V+VS+ EIYN YIYDL F
Sbjct: 186 SSKRQVD-----PEFADMITVQEFCKAEEVDEDSV-YGVFVSYIEIYNNYIYDLLEEVPF 239
Query: 288 VPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNA 347
P+ K + K+LR +D ++ ++V ++EA+ + G K + +A T LN
Sbjct: 240 DPIKPKPPQSKLLR--EDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRE 297
Query: 348 SSRSHSIFTVKILQIE-DSEMSRVIR------VSELSLCDLAGSERTMKTQNEGERLRET 400
SSRSHS+F +K++Q D++ V++ +S+LSL DLAGSERT +T+ EG RLRE
Sbjct: 298 SSRSHSVFNIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTRAEGNRLREA 357
Query: 401 GNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCY 460
GNIN SL+TL C++VL+ ++ + VP+R+SKLTH F+++F+G+GK+ MIV ++
Sbjct: 358 GNINQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKA 417
Query: 461 LAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATI 520
Y+E L V++F+ + Q+V V ++ + L + + + +V +
Sbjct: 418 EDYEENLQVMRFAEVTQEVEVARPVDKAICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSF 477
Query: 521 SWENSLE--DLMEDEDLVEELENAEETQNVETKLLDE-----DLDKTL--EENKAFISHE 571
S E D+ +++ L +E E+ N+ ++DE + K L E + A +S E
Sbjct: 478 PPLPSCEILDINDEQTLPRLIEALEKRHNLRQMMIDEFNKQSNAFKALLQEFDNAVLSKE 537
Query: 572 --------EKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKET 623
EK K +I K ++ +K+ TLE+KI E+ ++ T + + + + ++
Sbjct: 538 NHMQGKLNEKEK---MISGQKLEIERLEKKNKTLEYKI--EILEKTTTIYEEDKRNLQQE 592
Query: 624 LLQEREILEE--NAERRL-AIFKDLVGKCDTR--EEAAKDICATKVETEEATACLELKFN 678
L + + L+ + +RRL A + +V + + +E + + A ++E + + K
Sbjct: 593 LETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQNKLWVKDEKLK 652
Query: 679 QIKAELAKTKGELIKTKEELKKRENESDSLIQ 710
Q+KA + + K E K E RE + + + Q
Sbjct: 653 QLKAIVTEPKTE----KPERPSRERDREKVTQ 680
Score = 38.1 bits (87), Expect = 0.077
Identities = 47/196 (23%), Positives = 97/196 (49%), Gaps = 25/196 (12%)
Query: 999 VKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDE 1058
+++ I E N++++ + +A+ +E V SK++H +L ++ EK+ + G K E
Sbjct: 507 LRQMMIDEFNKQSN---AFKALLQEFDNAVL--SKENHMQGKLNEK-EKM---ISGQKLE 557
Query: 1059 NNRLKEKEHKNQD---DLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQG 1115
RL EK++K + ++L++ T+ ++ K LQ++ T + ++Q KR L QG
Sbjct: 558 IERL-EKKNKTLEYKIEILEKTTTIYEEDKRNLQQELETQNQKLQRQFSDKRRLEARLQG 616
Query: 1116 VTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 1175
+ ET ++ +K EC +Q LE ++ + + LK+ + + + K
Sbjct: 617 MV--------TETTMKWEK-ECERRVAAKQ--LEMQNKLWVKDEKLKQLKAIVTEP-KTE 664
Query: 1176 KDLNVKELKLKEEITQ 1191
K + +E++TQ
Sbjct: 665 KPERPSRERDREKVTQ 680
Score = 32.3 bits (72), Expect = 4.2
Identities = 33/158 (20%), Positives = 75/158 (47%), Gaps = 9/158 (5%)
Query: 1151 ESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK-HLLQ----L 1205
++++ + + + + H+Q + N K+ + KL+ E + N + K +L+ +
Sbjct: 523 KALLQEFDNAVLSKENHMQGKL-NEKEKMISGQKLEIERLEKKNKTLEYKIEILEKTTTI 581
Query: 1206 KEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKE 1265
EE++ +QE E ++L + + L+A LQ + EK + + KQ++ +
Sbjct: 582 YEEDKRNLQQELETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQ 641
Query: 1266 VSVMRDEDKLLRIKINELE---KKKNQCSQELDMKQRT 1300
+ ++KL ++K E +K + S+E D ++ T
Sbjct: 642 NKLWVKDEKLKQLKAIVTEPKTEKPERPSRERDREKVT 679
Score = 31.2 bits (69), Expect = 9.4
Identities = 55/282 (19%), Positives = 120/282 (42%), Gaps = 33/282 (11%)
Query: 1176 KDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK 1235
K N + L+E + + M+ L KE+ + E E+L+++ + + L+
Sbjct: 517 KQSNAFKALLQEFDNAVLSKENHMQGKLNEKEKMISGQKLEIERLEKKNKTLEYKIEILE 576
Query: 1236 ADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKK-KNQCSQEL 1294
EED +L+++L + Q +++Q++ S R + L+ + E K + +C + +
Sbjct: 577 KTTTIYEEDKRNLQQEL---ETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRV 633
Query: 1295 DMKQRTIQ-------QLKEQLNNQKVEEAIQQYERACKDLN---VKEKIIEDMRMTLEEQ 1344
KQ +Q + +QL E ++ ER ++ + V ++ + + L
Sbjct: 634 AAKQLEMQNKLWVKDEKLKQLKAIVTEPKTEKPERPSRERDREKVTQRSVSPSPVPLSSN 693
Query: 1345 EQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKN--NQRSNKEHENNTDVLGKLT 1402
Q+ Q L ++ +L + C+ + + ++ K NT + K+T
Sbjct: 694 YIAQISNGQQLMSQ--------PQLHRRSNSCSSISVASCISEWEQKIPTYNTPL--KVT 743
Query: 1403 NL----QDELQESEQKYNADRKK---WLEEKMMLITQAKEAE 1437
++ Q E +S+ +DR++ W E + ++ T E E
Sbjct: 744 SIARRRQQEPGQSKTCIVSDRRRGMYWTEGREVVPTFRNEIE 785
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 250 bits (638), Expect = 1e-65
Identities = 365/1599 (22%), Positives = 703/1599 (43%), Gaps = 234/1599 (14%)
Query: 268 KFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAY 327
+F + VS+ EIYNE I DL QK K L + +DV ++ DL V S+ A
Sbjct: 124 EFLLRVSYMEIYNETITDLLCGT----QKMKPLIIREDVNRNVYVADLTEEVVYTSEMAL 179
Query: 328 RLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRV---IRVSELSLCDLAGS 384
+ + G K + TK+N SSRSH+IF + + E E S ++VS L+L DLAGS
Sbjct: 180 KWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGS 239
Query: 385 ERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFF 444
ER +T G RL+E NIN SL LG+ I L + + F + +R+SKLT Q+
Sbjct: 240 ERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGF---INYRDSKLTRILQNSL 296
Query: 445 NGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLN--SSQEKLFGPVKSSQDV 502
G K +I I+ +++DETL L+F++ A+ + +N S+ E L +K +
Sbjct: 297 GGNAKTRIICTITP--VSFDETLTALQFASTAKYMKNTPYVNEVSTDEAL---LKRYRKE 351
Query: 503 SLDSNSNSKILNVK-RATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTL 561
+D + ++++ RA ++ L L+E++DL+++++N E+ +N+ T++L TL
Sbjct: 352 IMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQN-EKIENL-TRMLVTSSSLTL 409
Query: 562 EENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFK 621
++ + + KR++ + + K K +F I +T + + +
Sbjct: 410 QQE---LKAKRKRRVTWCLGKINKM----KNSNYADQFNIPTNITTKTHKLSINLLREID 462
Query: 622 ETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIK 681
E++ E ++ + I + K +E ++ + + + + L L + Q++
Sbjct: 463 ESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDN----LVLDYEQLR 518
Query: 682 AELAKTKGEL-IKTKEELK-----KRENESDSLIQEL-ETSNKKIITQNQRI--KELINI 732
E K + EL +K K +L +R+ + D +Q + E SN K + ++ + ++L N
Sbjct: 519 TE--KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENE 576
Query: 733 IDQKEDTINE----FQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKIC 788
+ K + + E + L+ ++++ N K D S + E++E PK K +
Sbjct: 577 LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL--------ESIEDPKQMKQTLF 628
Query: 789 SERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIE-DIRVLQENNEGL 847
+ + AK+ S + S E ++K +E+ ++E DI++ Q E
Sbjct: 629 ---------DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAK 679
Query: 848 RAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAEL 907
+ + +E EL++ E +L I ++ NL L ++ +Q EL
Sbjct: 680 KKMQVDLEKELQSAFNEITKLTSLI---DGKVPKDLLCNLELEGKITDLQK-------EL 729
Query: 908 HVQKSKNQEQEEKIMKLS------NEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQI 961
+ + +N+ E+++ LS +E+E + I + ++ ++ ++ D+L + + V +
Sbjct: 730 NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS-EVVHKE 788
Query: 962 SNIDLLNLRDLSNGSEEDNLPNTQLDLLGND---------YLVSKQVKEYRIQEPNREN- 1011
S + L L ++ G +D+L TQ + D ++ +Q + ++E R N
Sbjct: 789 SRVQGL-LEEI--GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 1012 ----------SFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNR 1061
F SS+ A+ E + +K+ +++E ++E+L+ +++ +D +
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN-RDSTLQ 904
Query: 1062 LKEKEHKNQDDLLKEK-ETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK 1120
E+E L+ EK + ++++K QEK+ +Q +E + S++ V
Sbjct: 905 TVERE----KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 1121 AKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQD---SVKNTKD 1177
++L LE+ K L+ I E+ S L +E N E ++ Q + +D
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 1178 LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKAD 1237
L K + + ++ + + L +E+ E L++ L + A + LK D
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE--------LQQMLESVIAEKEQLKTD 1072
Query: 1238 LQRKEEDYADLKEKLTDAKKQIKQVQKEVS-----VMRDEDKLLRI--KINELEKKKNQC 1290
L+ E + +E+L ++K+ Q+ V+ ++ E +L R ++ E+E+K +
Sbjct: 1073 LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132
Query: 1291 SQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVE 1350
SQ+L KQ+ + ++E+++ ++++ I + E +L KE +TLE E ++E
Sbjct: 1133 SQQLQEKQQQLLNVQEEMS--EMQKKINEIENLKNELKNKE-------LTLEHMETERLE 1183
Query: 1351 QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN---------------------- 1388
Q L EEV+ + E + KE ET+ +
Sbjct: 1184 LAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH 1243
Query: 1389 -KEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKY 1447
KEH+ D L + + + + Q K EE +L + + N+ K+
Sbjct: 1244 LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV-----KEV 1298
Query: 1448 AEDRERFFKQQNEMEILTAQLTEKDS-DLQKWREERDQLVAALEIQLKALISSNVQKDN- 1505
+E +E NE+E+LT Q T KDS L + ER +L + + + S ++DN
Sbjct: 1299 SETQE----TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
Query: 1506 ---------EIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKI 1556
+ +QLK I ET +I + + K+ S + + E E+ + K
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETL---AKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP 1411
Query: 1557 EDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKR 1616
+D +++ +EI+ L ++ H + K R +
Sbjct: 1412 KDSALL-------------------RIEIEMLGLS-KRLQESHDEMKSVAKEKDDLQRLQ 1451
Query: 1617 KSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVA---IRPSSKKTYSLRSQ 1673
+ + E D +K EN K ++ ++E KVA ++ + LR
Sbjct: 1452 EVLQSESDQLK-ENIKEIVA-----------KHLETEEELKVAHCCLKEQEETINELR-- 1497
Query: 1674 ASIIGVNLATKKKE-GTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQ 1732
VNL+ K+ E T+QK L+ LQ+K ++I E + + +E V++
Sbjct: 1498 -----VNLSEKETEISTIQK---QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
Query: 1733 PKRAK--RKLYTSEISSPIDISGQVILMDQKMKESDHQI 1769
K+ K RK S + S I +++ + +++ES +I
Sbjct: 1550 LKQFKEHRKAKDSALQS---IESKMLELTNRLQESQEEI 1585
Score = 173 bits (439), Expect = 1e-42
Identities = 318/1594 (19%), Positives = 665/1594 (41%), Gaps = 235/1594 (14%)
Query: 61 VCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFG 120
VC+R+RP E+ L V+ V+ + ++ F+F +VF
Sbjct: 9 VCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDG--------------SKSFNFDRVFH 54
Query: 121 PATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLF 180
T K ++ + ++G + IF YG T SGKTYT G+E+++G++PR ++ +F
Sbjct: 55 GNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIF 114
Query: 181 DSLQERLYTKMNLKPHRSREYLRLSSEQE--KEEIASKSALLRQIKEVTVHNDSDDTLY- 237
+K RE+L S E E I +++K + + D + +Y
Sbjct: 115 ----------QKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYV 164
Query: 238 GSLTNS-LNISEFE-------ESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVP 289
LT + SE E + Y + +N +S + +F
Sbjct: 165 ADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRS---------------HTIFRM 209
Query: 290 VSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASS 349
+ +K + VK + L + ++ S+ A + G++ K +
Sbjct: 210 ILESREKGEPSNCEGSVK----VSHLNLVDLAGSERAAQTGAAGVR------LKEGCNIN 259
Query: 350 RSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINT-SLL 408
RS I I ++ D ++ I + S+ T QN +T I T + +
Sbjct: 260 RSLFILGQVIKKLSDGQVGGFINYRD--------SKLTRILQNSLGGNAKTRIICTITPV 311
Query: 409 TLGKCINVLKNSEKSKFQQHVPF------RESKLTHYFQSFFNGKGKICMI-VNISQCYL 461
+ + + L+ + +K+ ++ P+ E+ L Y + + K ++ + + +
Sbjct: 312 SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAM 371
Query: 462 AYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATIS 521
D+ +L+ + QKV N E L + +S ++L +K ++ ++
Sbjct: 372 EKDQLAQLLEEKDLLQKV-----QNEKIENLTRMLVTSSSLTLQQELKAK----RKRRVT 422
Query: 522 WENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIE 581
W + M++ + ++ N +T L +L + ++E+ S + LD +
Sbjct: 423 WCLGKINKMKNSNYADQF-NIPTNITTKTHKLSINLLREIDESVCSES-DVFSNTLDTLS 480
Query: 582 DLK----KKLINEKKEKLTLEFKIREEVTQEFTQYWAQR-EADFKETLLQEREILE--EN 634
+++ KL+N++ + L +R + Y R E + E L+E+ L+ E
Sbjct: 481 EIEWNPATKLLNQENIESELN-SLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA 539
Query: 635 AERR------------LAIFKDLVGKCDTREEAAKDICATKV----ETEEATACLE---- 674
ER+ ++ K+LV + + ++ ++KV E E+ L+
Sbjct: 540 LERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYID 599
Query: 675 -LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQN----QRIKEL 729
K IK +L+ + E I+ +++K+ +++++ + + + + ++N +++KEL
Sbjct: 600 SQKLENIKMDLSYSL-ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKEL 658
Query: 730 INIIDQKEDTINEFQ-----------NLKSHMENTFKCNDKADTSSLI---INNKLICNE 775
Q E+ I +Q +L+ +++ F N+ +SLI + L+CN
Sbjct: 659 ATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAF--NEITKLTSLIDGKVPKDLLCNL 716
Query: 776 TVEVPKDSKSKICSERKRVNENELQQDE----PPAKKGSIHVSSAITEDQKKSEEVRPNI 831
+E K K V ENE ++E K V E Q KSEE+
Sbjct: 717 ELEGKITDLQK--ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIIT 774
Query: 832 AEIED-----------IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELS 880
+E + ++ L E + L T ++ K+ +E + F+Q+
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
Query: 881 LSEKKN-------LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATR 933
+ ++N + LSKE Q+ S+ EL + + QE+ ++ + NE+E
Sbjct: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894
Query: 934 SITNNVSQIKLMH---TKIDE--LRTLDSVSQIS--NIDLLNLRDLSNGSEEDNLPNTQL 986
+ N S ++ + T I E +TL+ V ++ DL L++ S E D L +
Sbjct: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQE-SLQIERDQLKSDIH 953
Query: 987 DLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIE 1046
D + + +Q++ N S E I +I + S+ H E + +
Sbjct: 954 DTVNMNIDTQEQLR-------NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
Query: 1047 KLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLK--EELQEKNVTLDVQIQHVVE 1104
+ Q ++ G D+ L+ K + +K+ E + QQ K +QEKN + + E
Sbjct: 1007 EFQQKMVGI-DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE 1065
Query: 1105 GKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEF 1164
++ ++L + + +EL + + K + A+ + ++KE + + L E
Sbjct: 1066 KEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEV 1125
Query: 1165 QEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLL-QLKEEEEETNRQETEKLKEE 1223
+E L++ + ++ + L ++EE++++ + ++++L +LK +E ETE+L E
Sbjct: 1126 EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL--E 1183
Query: 1224 LSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINEL 1283
L+ Q+ E+Y ++K +T +K +K++QK RD LR I E+
Sbjct: 1184 LA-------------QKLNENYEEVK-SITKERKVLKELQKSFETERDH---LRGYIREI 1226
Query: 1284 EKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE 1343
E Q +EL + LKE +E I + R +V EK + + E
Sbjct: 1227 EATGLQTKEELKIAH---IHLKEH------QETIDELRR-----SVSEKTAQIINTQDLE 1272
Query: 1344 QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTN 1403
+ T+++++ + + +E+ E+ + +E N+LE Q + K+ + +
Sbjct: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332
Query: 1404 LQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEI 1463
L ++ QES+++ K L ++ + KEA +++ ++K++ + ++ +
Sbjct: 1333 LNEKFQESQEEI-----KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 1464 LTAQLTEKDSDLQKWREERDQL----VAALEIQLKAL------------ISSNVQKDNEI 1507
+ + EKD++ K E +Q A L I+++ L + S ++ +++
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 1508 EQLKRII-SETSKIETQIMDIKPKRISSADPDKL 1540
++L+ ++ SE+ +++ I +I K + + + K+
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKV 1481
Score = 147 bits (370), Expect = 1e-34
Identities = 333/1778 (18%), Positives = 732/1778 (41%), Gaps = 263/1778 (14%)
Query: 135 QPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLFDSLQERLYTKMNLK 194
Q + +L K + + G + +Y Q +E + LN + + L+E+L + +
Sbjct: 845 QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM-EQLKEQLENRDSTL 903
Query: 195 PHRSREYLRLSSE------------QEKEEIASKSALLRQIKEVTVHNDSDDTLYGSLTN 242
RE ++ + QEK+++ L QI+ + +D DT+ ++
Sbjct: 904 QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL-QIERDQLKSDIHDTVNMNIDT 962
Query: 243 SLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYN-----EYIYDLFVPVSSK--FQ 295
+ ES+K +++ + + I V + N + V + K +
Sbjct: 963 QEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022
Query: 296 KRKMLRLSQDVKGYSFIKDLQWI--QVSDSKEAYRLLKLGIKHQSVAFTKLN-NASSRSH 352
+ L+ DVK I+ + I + + E ++L+ I + T L N
Sbjct: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE 1082
Query: 353 SIFTVKILQIEDSEMSRVI---------RVSELS-LCD-LAGSERTMKTQNEG--ERLRE 399
+ +++L E + ++ + ELS CD LA E +K +++ E+ ++
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142
Query: 400 TGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQC 459
N+ + + K IN ++N + + +E L H + ++ +N +
Sbjct: 1143 LLNVQEEMSEMQKKINEIEN-----LKNELKNKELTLEHMETE----RLELAQKLNEN-- 1191
Query: 460 YLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRAT 519
Y+E ++ K + +++ + + ++ L G ++ + L + KI ++
Sbjct: 1192 ---YEEVKSITKERKVLKEL--QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK- 1245
Query: 520 ISWENSLEDLMED-EDLVEELENAEETQNVETKLLDE-----DLDKTLEENKAFISHEEK 573
+ ++++L + ++ N ++ + TKL +E + + L K +E
Sbjct: 1246 -EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304
Query: 574 RKLLDLIEDLKKK-----LINEKKEKLTLEFKIREEVTQEFTQYWAQRE--ADFKETLLQ 626
L+L+ + L + E+L L K +E +E +R+ KE L
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES-QEEIKSLTKERDNLKTIKEALEV 1363
Query: 627 EREILEENAERRLAIFKDLVGKCD-TREEAAKDICATKVETE--------EATACLELKF 677
+ + L+E+ LA ++ K + + KD TK+ +E A +E++
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 678 NQIKAELAKTKGEL---IKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINI-- 732
+ L ++ E+ K K++L++ + S +L+ + K+I+ ++ +E + +
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
Query: 733 --IDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLI--CNETVEVPKDSKSKIC 788
+ ++E+TINE + S E K + IN+KL E E + K
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEA---INDKLQNKIQEIYEKEEQFNIKQI 1540
Query: 789 SE-RKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEI-EDIRVLQENNEG 846
SE +++VNE + ++ AK SA+ + K E+ + E E+I+++ + E
Sbjct: 1541 SEVQEKVNELKQFKEHRKAK------DSALQSIESKMLELTNRLQESQEEIQIMIKEKEE 1594
Query: 847 LRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAE 906
++ ++ L+ E+++ E K+IV +E E + L ++ V + Q + E
Sbjct: 1595 MKR----VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA-VNETQEK----MCE 1645
Query: 907 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 966
+ K + + Q+ + + E T+ + N+ +++ + + D+LR+++ ++
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKV----- 1700
Query: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKE 1026
E D L + + D +++K + + + + E+ E
Sbjct: 1701 ----------ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNE 1750
Query: 1027 IVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQD--DLLKEKETLIQQL 1084
I H + L+ Q K+Q E++ + LKE++ ++ EK + +
Sbjct: 1751 ISNMQKDLEHSNDALKAQDLKIQEELR---IAHMHLKEQQETIDKLRGIVSEKTDKLSNM 1807
Query: 1085 KEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLE 1144
+++L+ N L +IQ + + L L + V + K+ E+E + + K + +KLE
Sbjct: 1808 QKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE 1867
Query: 1145 QDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHL-L 1203
+E ++ KL NL+E ++ +K +L E LK E QL +LQ+ K L
Sbjct: 1868 ---IENLNLAQKLHENLEE----MKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
Query: 1204 QLKEEEE------ETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKK 1257
++++E + + +++ +KL+E++S + + +++ DL + +++ ++L +
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
Query: 1258 QIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAI 1317
Q+ +V+++V++ KINE+E+ K Q + ++ ++++ QL +K+ E++
Sbjct: 1981 QLLRVKEDVNMSHK-------KINEMEQLKKQFEAQ-NLSMQSVRMDNFQL-TKKLHESL 2031
Query: 1318 QQYERACKDLNVKEKIIEDMRM-------TLEE-----QEQTQVE---------QDQVLE 1356
++ K+ + +I E ++M TL E ++ QV+ Q + E
Sbjct: 2032 EEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTE 2091
Query: 1357 AKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHE------------NNTDVLGKLTNL 1404
+ E+ R+ L+++ E + E N + E E N + T
Sbjct: 2092 SLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKH 2151
Query: 1405 QDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEIL 1464
++L + Q+ + + + +++ +++ + + +++ + K+ D ++Q E+ ++
Sbjct: 2152 IEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKEL-LI 2210
Query: 1465 TAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETS--KIET 1522
Q ++D D+ RE RD + N D IE++ + SE+ I+T
Sbjct: 2211 KIQHLQQDCDVPS-RELRD-------------LKLNQNMDLHIEEILKDFSESEFPSIKT 2256
Query: 1523 QIMDIKPKRISSADPDKLQTEPLSTSFEISR--------------------NKI-----E 1557
+ + R + + E L+T F+I + N+I E
Sbjct: 2257 EFQQVLSNR---KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNE 2313
Query: 1558 DGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTV--KIPKARK 1615
S +S E +Q + K + E F Q K ++ P T K P
Sbjct: 2314 STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2373
Query: 1616 RKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYS---LRS 1672
R + E + + EN + + + S++ KE K+ + + +
Sbjct: 2374 RATQLTTEKIRELENS------------LHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421
Query: 1673 QASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSK----AKKIIETMSSSKLSNVEASKE 1728
QA + N +K + T+Q +LQ K AK E + K+ V+ E
Sbjct: 2422 QAKVHESNKCLEKTKETIQ-----------VLQDKVALGAKPYKEEIEDLKMKLVKIDLE 2470
Query: 1729 NVSQPKRAKRKLYTSEISSPIDISGQVI-LMDQKMKES 1765
+ K ++++ S + ++ +VI L+ + ++ S
Sbjct: 2471 KMKNAKEFEKEI--SATKATVEYQKEVIRLLRENLRRS 2506
Score = 117 bits (294), Expect = 8e-26
Identities = 221/1153 (19%), Positives = 479/1153 (41%), Gaps = 179/1153 (15%)
Query: 459 CYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRA 518
C +ET+N L+ + +++K T+ E + N K+ N +
Sbjct: 1485 CLKEQEETINELRVN-LSEKETEISTIQKQLEAI----------------NDKLQNKIQE 1527
Query: 519 TISWEN--SLEDLMEDEDLVEELENAEE--------TQNVETKLLD--EDLDKTLEENKA 566
E +++ + E ++ V EL+ +E Q++E+K+L+ L ++ EE +
Sbjct: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 567 FISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFK----E 622
I +E+ K + +++ + E +++ + K +E +F + A E K E
Sbjct: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE 1647
Query: 623 TLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKA 682
L ++ E + N E L E + + + + L+++ +Q+K
Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
Query: 683 ELAKTKGELIKTKEELK---------------------KRENESDSLIQELETSNKKIIT 721
L +T ++ +EELK ++ NE ++ ++LE SN +
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA 1767
Query: 722 QNQRIKELINI----IDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777
Q+ +I+E + I + ++++TI++ + + S K + ++ + N+ E +
Sbjct: 1768 QDLKIQEELRIAHMHLKEQQETIDKLRGIVSE-----KTDKLSNMQKDLENSNAKLQEKI 1822
Query: 778 EVPKDSKSKICSERKRVNE-----NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIA 832
+ K ++ ++ + +K VNE +E++Q + K S+ +S E+ ++++ N+
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLE 1882
Query: 833 EIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKE 892
E++ + ++N LR T++ E KE E + + QQEL + LSKE
Sbjct: 1883 EMKSVMKERDN---LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM----LSKE 1935
Query: 893 VQQIQSNYDIAIAELHVQKSKNQEQEEK----IMKLSNEIETATRSITNNVSQIKLMHTK 948
++ I+E +Q S Q+ +K + K E++ + + + H K
Sbjct: 1936 HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK 1995
Query: 949 IDELRTLDSVSQISNIDLLNLR--------DLSNGSEEDNLPNTQLDLLGN--------- 991
I+E+ L + N+ + ++R L EE + + D L
Sbjct: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMER 2055
Query: 992 -------DYLVSKQVKEYRIQEPNR--ENSFHSSIEAIWEEC---KEIVKASSKKSHQIE 1039
++++ + ++++ R + E++ E+C KE++K S+ E
Sbjct: 2056 DQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYE 2115
Query: 1040 ELEQQIEKLQAEVKGYKDENNRLKEK------EHKNQDDLLKEKETLIQQLKEELQEKNV 1093
L + L+ E++ K+ + R+K + K+ + L + + +++
Sbjct: 2116 CLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY 2175
Query: 1094 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESI 1153
L + E ++++ K KEL ++ + +C ++ +D+ +++
Sbjct: 2176 VLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNM 2235
Query: 1154 ILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT----NNLQDMKHLLQLKEEE 1209
L +E LK+F E S+K + L ++E+TQ N D++ L ++E
Sbjct: 2236 DLHIEEILKDFSESEFPSIKTEFQ---QVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292
Query: 1210 EE---------TNR------QETEKLKEELSASSARTQNLKADLQRKEE---DYADLKEK 1251
+ NR + TE + + S Q+LK+ ++ E+ +Y LK
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTS 2352
Query: 1252 LTDAKK--QIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309
L + Q K V +L KI ELE ++ + K+ I +++++L
Sbjct: 2353 LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412
Query: 1310 ---------NQKVEEAIQQYERACKDLNV-KEKI----------IEDMRMTLEEQEQTQV 1349
KV E+ + E+ + + V ++K+ IED++M L ++
Sbjct: 2413 VTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL-----VKI 2467
Query: 1350 EQDQVLEAKLEEVERLATELE-KWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDEL 1408
+ +++ AK E E AT+ +++++ L +N +RS + + T V+ + T +
Sbjct: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQD--TSVISEHT----DP 2521
Query: 1409 QESEQKYNADRKKWLEEKMMLITQAKEAENIR-NKEMKKYAEDRERFFKQQNEMEILTAQ 1467
Q S + + + + ++E+IR KE+ K + E+ KQ+NE L +
Sbjct: 2522 QPSNKPLTCGGGSGIVQNTKALIL--KSEHIRLEKEISKLKQQNEQLIKQKNE---LLSN 2576
Query: 1468 LTEKDSDLQKWRE 1480
++++ W+E
Sbjct: 2577 NQHLSNEVKTWKE 2589
Score = 77.8 bits (190), Expect = 9e-14
Identities = 258/1254 (20%), Positives = 502/1254 (40%), Gaps = 279/1254 (22%)
Query: 166 EENIGILPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKE 225
E I + + L + D LQ ++ + + E + E +E ++ L+Q KE
Sbjct: 1504 ETEISTIQKQLEAINDKLQNKIQ-----EIYEKEEQFNIKQISEVQEKVNE---LKQFKE 1555
Query: 226 VTVHNDSDDTLYGS-------LTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEI 278
H + D+ S LTN L S+ E I E+ + +I
Sbjct: 1556 ---HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA--------LQI 1604
Query: 279 YNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQS 338
+ + + + +K ++ SQ+ K Y F+K V++++E ++ ++ +
Sbjct: 1605 ERDQLKENTKEIVAKMKE------SQE-KEYQFLK---MTAVNETQE--KMCEIEHLKEQ 1652
Query: 339 VAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEG--ER 396
KLN + + +I +IL EM V + + DL E T+K + + E
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERD----DLRSVEETLKVERDQLKEN 1708
Query: 397 LRETGNINTSLLTLGKCINV-LKNSEK---------SKFQQHVPFRESKLTHYFQSFFNG 446
LRET + K +++ LK ++ S+ + + L H +
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 447 KGKICMIVNISQCYLA-YDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLD 505
KI + I+ +L ET++ L+ +++K D L++ Q+ L Q+ +
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLR-GIVSEKT---DKLSNMQKDLENSNAKLQEKIQE 1824
Query: 506 SNSNS-------KILNVKRATISWENSLEDLMEDEDL------VEEL-------ENAEET 545
+N K +N + +S L+ ++D+ L +E L EN EE
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
Query: 546 QNV-----------ETKLLDED-LDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKE 593
++V ET L+ D L ++L+E KA + L++ ++LK + K+
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKA--------RDLEIQQELKTARMLSKEH 1936
Query: 594 KLTLEFKIREEVTQEFTQYW-AQREADFKETLLQEREILEENAERRLAIFKDLVG----K 648
K T++ K+RE+++++ Q Q++ D + LQ++ + E +L K+ V K
Sbjct: 1937 KETVD-KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK 1995
Query: 649 CDTREEAAKDICA-------TKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKR 701
+ E+ K A +++ + T L +I+ +AK + EL + KE LK
Sbjct: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI-VAKERDELRRIKESLKME 2054
Query: 702 ENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLK-SHMENTFKCNDKA 760
++ + ++E+ ++ QN ++K ++ + + E K S ++ K +
Sbjct: 2055 RDQFIATLREMIARDR----QNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110
Query: 761 DTSSLIINN-KLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITE 819
D +N L + +E K+ ++ + ++ LQ H+ T
Sbjct: 2111 DDHYECLNRLSLDLEKEIEFQKELSMRV---KANLSLPYLQTK---------HIEKLFTA 2158
Query: 820 DQKKSEEVRPNIAEIEDI-----RVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH 874
+Q+ S E + +++ + ++ +E +E + F E + +E E++ EL +I H
Sbjct: 2159 NQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF----EMDFIDEVEKQKELLIKIQH 2214
Query: 875 FQQELSL-------------------------SEKKNLTLSKEVQQIQSNYDIAIAELH- 908
QQ+ + SE + ++ E QQ+ SN L
Sbjct: 2215 LQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEE 2274
Query: 909 -------VQKSKN--QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKID-----ELRT 954
++K KN Q++ ++I +++N +I N ++ + I +L++
Sbjct: 2275 WLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKS 2334
Query: 955 LDSVSQ--ISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSK--QVKEYRIQEPNRE 1010
L ++ N L L++G++ + P TQ + N ++ S+ Q+ +I+E E
Sbjct: 2335 LKEKNEKLFKNYQTLKT-SLASGAQVN--PTTQDNK--NPHVTSRATQLTTEKIRE--LE 2387
Query: 1011 NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQ 1070
NS H + E+ + E +I K+Q E++ D +L+ K H++
Sbjct: 2388 NSLHEAKESAMHK------------------ESKIIKMQKELEVTNDIIAKLQAKVHESN 2429
Query: 1071 DDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETIL 1130
L K KET+ V++ K AL G YK +I++L+
Sbjct: 2430 KCLEKTKETI--------------------QVLQDKVAL-----GAKPYKEEIEDLK--- 2461
Query: 1131 ETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT 1190
KL + LEK +N KEF++ + + K T + KE I
Sbjct: 2462 ----------MKLVKIDLEK-------MKNAKEFEKEI-SATKATVEYQ------KEVIR 2497
Query: 1191 QLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKE 1250
L NL+ + E T+ Q + K S QN KA + + E
Sbjct: 2498 LLRENLRRSQQAQDTSVISEHTDPQPSNK-PLTCGGGSGIVQNTKALILKSEH------- 2549
Query: 1251 KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQEL-DMKQRTIQQ 1303
+++KE+S ++ +++ L + NEL S E+ K+RT+++
Sbjct: 2550 ---------IRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKR 2594
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 227 bits (578), Expect = 9e-59
Identities = 301/1358 (22%), Positives = 590/1358 (43%), Gaps = 180/1358 (13%)
Query: 248 EFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVK 307
E+ S+ D E+ S F SF EIYNE IYDL S+ R+ ++ K
Sbjct: 141 EYLFSLIDREKEKAGAGKS--FLCKCSFIEIYNEQIYDLLDSASAGLYLREHIK-----K 193
Query: 308 GYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEM 367
G + ++ + V+ + EAY++L G +++ VA T +N SSRSH++FT+ I +E S
Sbjct: 194 GVFVVGAVEQV-VTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNE 252
Query: 368 SRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQ 427
IR S L+L DLAGSER T EG RL+E GNIN SL LG+ I L + K Q+
Sbjct: 253 IVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGK-QR 311
Query: 428 HVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFS----AIAQKVCVPD 483
HV +R+SKLT + G K +I N+ + ETL+ L F+ I K V +
Sbjct: 312 HVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNE 371
Query: 484 TLNSSQEKLFGPVKSSQD-----VSLDSNSNSKILNVKRATISWENSLEDLM-------E 531
+ +L VK ++ S + S + K+ T E E ++ E
Sbjct: 372 DTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQE 431
Query: 532 DEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKR--KLLDLIEDLKKKLIN 589
+ L+E++ E+ L +K ++ NK + E + +L L ++ + +
Sbjct: 432 KKSLIEKVTQLED--------LTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLP 483
Query: 590 EKKEKLTLEFK-----IREE------VTQEFTQYWAQREADFKETLLQEREILEENAERR 638
E++++L E + +RE+ V + + + RE + + LL+ + +E +
Sbjct: 484 EEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQT 543
Query: 639 LAIFKDLVGKCDTREEAAKDI--CATKVETEEA----TACLELKFNQIKAELAKTKGELI 692
+A + + E++ K+ + K + E T L+ + QI+ EL +K E
Sbjct: 544 IAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYE 603
Query: 693 KTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMEN 752
+ KE +KR+ E +S +Q L+ +N NL++ +E
Sbjct: 604 EFKELTRKRQLELESELQSLQKAN---------------------------LNLENLLEA 636
Query: 753 TFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPP-AKKGSI 811
T C + + S L NK+ + +K+ +++ + + P GS+
Sbjct: 637 TKACK-RQEVSQL---NKIHAETLKIITTPTKA------YQLHSRPVPKLSPEMGSFGSL 686
Query: 812 HV-SSAITEDQKKSEEVRPNIAE------IEDIRVLQENNEGLRAFLLTIENELKNEKEE 864
+ +S+I ++ +E V P + E E++R +QE L+A L E E KN K +
Sbjct: 687 YTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKL--DEEEHKNLKLQ 744
Query: 865 KAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKL 924
+ ++K H Q L + + +K+ +++ S ++ +L ++KN + ++
Sbjct: 745 Q-HVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEV--- 800
Query: 925 SNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNT 984
+++ S +S +KL ++ +Q + L+ R + + DNL
Sbjct: 801 -HDLRVVLHSADKELSSVKLEYSSF-------KTNQEKEFNKLSERHMHVQLQLDNL--- 849
Query: 985 QLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ 1044
L N+ L+ + ++S+ + E + E ++ + + E L+
Sbjct: 850 ---RLENEKLLESKA--------CLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSD 898
Query: 1045 IEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVE 1104
+ L ++ K+ NN+L + +++++ KE +++ +++E Q++ + Q+
Sbjct: 899 LNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQM----- 953
Query: 1105 GKRALSELTQGVTCYKAKIKEL-ETILETQKVECSHSAKLEQD---ILEKESIILKLERN 1160
AK+++L E++L T+KV S + D + + + I +L +
Sbjct: 954 ----------------AKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTS 997
Query: 1161 LKEFQEHLQDSVKNTKDLNVK---ELKLKEE----ITQLTNNLQDMKHLLQLKEEEEETN 1213
+ E E + + KD+N K L +EE I + ++ D+K L+L+ E+
Sbjct: 998 VCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIE 1057
Query: 1214 R-----------QETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQV 1262
R ++ L E S Q+ + +L +KE +L+ KL K++++Q
Sbjct: 1058 RDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQK 1117
Query: 1263 QKEVSV-MRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQ-Y 1320
+ E + MR + ++ + + K + + + Q +E + + + +++
Sbjct: 1118 KNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLV 1177
Query: 1321 ERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLE 1380
+ +D VK I M+ L E E ++E Q++E K ++ ++++ KE +
Sbjct: 1178 TKLNEDREVKNAEILRMKEQLREMENLRLESQQLIE-KNWLLQGQLDDIKRQKENSDQNH 1236
Query: 1381 TKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIR 1440
N Q N++ E+ + L K + + +E+ + + + ++M + E E +
Sbjct: 1237 PDNQQLKNEQEESIKERLAK-SKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQ 1295
Query: 1441 NKEMKKYAED---RERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALI 1497
E K + E R + + E E + ++ ++ EE +LV + K
Sbjct: 1296 TLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQY 1355
Query: 1498 SSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSA 1535
++K+N R+ ET K+ + + +K K+ S +
Sbjct: 1356 VVRLKKEN-----VRLAEETEKLRAENVFLKEKKRSES 1388
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 177 bits (450), Expect = 6e-44
Identities = 284/1258 (22%), Positives = 520/1258 (41%), Gaps = 213/1258 (16%)
Query: 59 LQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKV 118
++V +RIRP EK EGC HI S T EPQ LG+ + F+F V
Sbjct: 10 VRVAVRIRPQLAKEK---IEGC-HICTSVTP--GEPQVFLGK---------DKAFTFDYV 54
Query: 119 FGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNV 178
F + Q++ + CI + ++ +G + +F YG T +GKTYT GT ++ I+ L +
Sbjct: 55 FDIDSQQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTM-GTGFDVNIVEEELGI 113
Query: 179 LFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYG 238
+ R+ ++L S +EK+ IA K+ L
Sbjct: 114 I----------------SRAVKHL-FKSIEEKKHIAIKNGL------------------- 137
Query: 239 SLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVP---VSSKFQ 295
+ F V F E+YNE + DLF + +K
Sbjct: 138 --------------------------PAPDFKVNAQFLELYNEEVLDLFDTTRDIDAK-S 170
Query: 296 KRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIF 355
K+ +R+ +D G + + V+ E + LKLG ++ A T++N SSRSH+IF
Sbjct: 171 KKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIF 230
Query: 356 TVKILQI------------------EDSEMSRVIRVS-ELSLCDLAGSERTMKTQNEGER 396
T+ + Q E ++M+ ++ + DLAGSER +T GER
Sbjct: 231 TIHVCQTRVCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGER 290
Query: 397 LRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNI 456
+E +IN LL LG I+ L +KSK HVP+R+SKLT Q G + MI +
Sbjct: 291 AKEGISINCGLLALGNVISAL--GDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACV 348
Query: 457 SQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVK 516
S + ETLN LK++ A+ N + + ++SQ ++ S+I ++
Sbjct: 349 SPSDRDFMETLNTLKYANRAR--------NIKNKVMVNQDRASQQINA---LRSEITRLQ 397
Query: 517 RATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKL 576
+ ++ + DE+ VE + + + E+ E N + + ++
Sbjct: 398 MELMEYKTGKRII--DEEGVESIND----------MFHENAMLQTENNNLRVRIKAMQET 445
Query: 577 LDLIEDLKKKLINEK-KEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENA 635
+D + +L++++ L + EE++ Y + E D + LL E E + EN
Sbjct: 446 VDALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIE-DLRAKLL-ESEAVNENL 503
Query: 636 ERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGEL---- 691
+ L + I ++ ET E + ++K + + K +
Sbjct: 504 RKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKSVAGKE 563
Query: 692 --IKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNL-KS 748
T +E K+ + S+ ELE + ++ ++ +E +++ED I+ ++ +S
Sbjct: 564 DNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEE---EEEEEEDDIDGGESSDES 620
Query: 749 HMENTFKCNDKAD----TSSLIINNKLI------CNETVEVPKDSKSKICSERKRVNENE 798
E+ K N +AD T + I KLI + K + K+ + ++ + +
Sbjct: 621 DSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQ 680
Query: 799 LQQDEPPAKKGSIH------VSSAITEDQKK-----SEEVRPNIAEIEDIRVLQENNEGL 847
L++D+ GS+ +E +KK E R A+ E R+L +N
Sbjct: 681 LERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLL-KNQSQY 739
Query: 848 RAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAEL 907
L ++ ++ K+ K L KQ+ Q++ L+E + ++++ Q D + L
Sbjct: 740 EKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLL 799
Query: 908 HVQKSKNQE-----QEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQIS 962
QK +NQE + E++ L ++ + + V++ KL + T S + +
Sbjct: 800 EAQK-RNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTR-KLSSSDAPAQDTGSSAAAVE 857
Query: 963 ------------NIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSK------QVKEYRI 1004
I + ++ L + N Q L +SK Q+ E R+
Sbjct: 858 TDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRV 917
Query: 1005 QEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDEN----N 1060
+ + S++EA + ++K + + + E+L ++ EK+ E G D+N N
Sbjct: 918 TDIIMQKMTISNMEA---DMNRLLKQREELTKRREKLSKRREKIVKE-NGEGDKNVANIN 973
Query: 1061 RLKEKEHKNQD---DLLKEKETLIQQLKEELQEKNVTLDV----QIQHVVEGKRALSE-L 1112
E N D D + + + I Q+ EE +E+ TLDV + E + L L
Sbjct: 974 EEMESLTANIDYINDSISDCQANIMQM-EEAKEEGETLDVTAVINACTLTEARYLLDHFL 1032
Query: 1113 TQGV------TCYKAKIKELE-TILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQ 1165
+ G+ +A+IK LE + +T+ + + L + EK + +L+ L
Sbjct: 1033 SMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHAL 1092
Query: 1166 EHLQDSV--KNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK 1221
+ L DSV +N +D ++ L ++ + D+ L + + + R+ T +++
Sbjct: 1093 QDL-DSVPLENVEDSTDEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQME 1149
Score = 63.5 bits (153), Expect = 2e-09
Identities = 98/442 (22%), Positives = 197/442 (44%), Gaps = 65/442 (14%)
Query: 1026 EIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEK---ETLIQ 1082
+++ + S QI L +I +LQ E+ YK + E+ ++ +D+ E +T
Sbjct: 374 KVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENN 433
Query: 1083 QLKEELQEKNVTLDV-----------QIQHVV----EGKRALSELTQG----VTCYKAKI 1123
L+ ++ T+D Q HV+ EG +S + + +AK+
Sbjct: 434 NLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKL 493
Query: 1124 KELETILETQKVEC----------SHSAKLEQDIL--EKESI-ILKLERN----LKEFQE 1166
E E + E + S S+ IL +KE+I I+ L + LK ++
Sbjct: 494 LESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEK 553
Query: 1167 HLQDSVKNTKDLNVKELKLKEE--ITQLTNNLQDMK-------HLLQLKEEEEETNRQET 1217
+ SV +D + + KEE +++ NN +++ H + +EEEEE + +
Sbjct: 554 RKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDG 613
Query: 1218 EKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD--EDKL 1275
+ +E + S N +ADL + A +K+KL D +++ QK + ++ E+KL
Sbjct: 614 GESSDESDSESDEKANYQADLANITCEIA-IKQKLID---ELENSQKRLQTLKKQYEEKL 669
Query: 1276 LRI--KINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKI 1333
+ + KI + + +++Q Q L + ++ +++ ++ E+ +Q + + L +K
Sbjct: 670 MMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSE-YEKKLQAMNKELQRLQAAQK- 727
Query: 1334 IEDMRMTLEE---QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQR--SN 1388
E R+ + ++Q + Q V+E K +V RL ++++ +EK E++ N+
Sbjct: 728 -EHARLLKNQSQYEKQLKKLQQDVMEMKKTKV-RLMKQMKEEQEKARLTESRRNREIAQL 785
Query: 1389 KEHENNTDVLGKLTNLQDELQE 1410
K+ + D +L Q QE
Sbjct: 786 KKDQRKRDHQLRLLEAQKRNQE 807
Score = 59.7 bits (143), Expect = 2e-08
Identities = 139/747 (18%), Positives = 311/747 (41%), Gaps = 98/747 (13%)
Query: 676 KFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQ 735
+ N +++E+ + + EL++ K + + E I ++ N + T+N ++ I + +
Sbjct: 385 QINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQE 444
Query: 736 KEDTI-NEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRV 794
D + + L S N +A + I+N + + ++ +D ++K+ E + V
Sbjct: 445 TVDALRSRITQLVSDQANHVLA--RAGEGNEEISNMI--HSYIKEIEDLRAKLL-ESEAV 499
Query: 795 NENELQQ-----DEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRA 849
NEN + P GS S I K++ E+ ++A+ +D+ L+ + +
Sbjct: 500 NENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEII-DLAK-KDLEKLKRKEKRKKK 557
Query: 850 FLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHV 909
+ E+ ++E+K +E +SE++N L E Q S+++ E
Sbjct: 558 SVAGKEDNTDTDQEKK-----------EEKGVSERENNELEVEESQEVSDHEDEEEEEEE 606
Query: 910 QKSK--NQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLL 967
++ E ++ S+E + N +I + IDEL
Sbjct: 607 EEDDIDGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQK---------- 656
Query: 968 NLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEI 1027
L+ L EE + ++ ++++ +++ + S+E+ EE +
Sbjct: 657 RLQTLKKQYEEKLM------------MLQHKIRDTQLERDQVLQNL-GSVESYSEEKAKK 703
Query: 1028 VKASSKKSHQIEELEQQIEKLQAEVKGYKD--ENNRLKEKEHKN-QDDLLKEKET---LI 1081
V++ +K +++ + +++++LQA K + +N EK+ K Q D+++ K+T L+
Sbjct: 704 VRSEYEK--KLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLM 761
Query: 1082 QQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSA 1141
+Q+KEE ++ +T + + + + K+ + + +A+ + E +L + E +
Sbjct: 762 KQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALR 821
Query: 1142 KLEQDILEKESIILKLERNLKEFQEHLQDS------VKNTKDLNVKELKLKEEITQLT-- 1193
+ + + +K + K+ R L QD+ V+ + K++ + ++
Sbjct: 822 RQVRPMSDK--VAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQAL 879
Query: 1194 -------NNLQDMKHLLQLKEEEEETNRQETEKLKEELS---ASSARTQNLKADLQR--- 1240
N + + L + +T R + + L+ ++ N++AD+ R
Sbjct: 880 PTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLK 939
Query: 1241 KEEDYADLKEKLTDAKKQIKQVQ----KEVSVMRDEDKLLRIKINELEKKKNQCSQELDM 1296
+ E+ +EKL+ +++I + K V+ + +E + L I+ + + C + M
Sbjct: 940 QREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANI-M 998
Query: 1297 KQRTIQQLKEQLNNQKVEEAIQQYERAC-----------KDLNV--KEKIIEDMRMTLEE 1343
+ ++ E L+ V A E K L KE I+ + L++
Sbjct: 999 QMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQ 1058
Query: 1344 QEQTQVEQDQVLEAKLEEVERLATELE 1370
E T Q+Q+L L+E L EL+
Sbjct: 1059 TEITSATQNQLLFHMLKEKAELNPELD 1085
Score = 55.5 bits (132), Expect = 5e-07
Identities = 146/738 (19%), Positives = 306/738 (41%), Gaps = 136/738 (18%)
Query: 848 RAFLLTIENELKNEKEEKAELNKQIVH---FQQELSLSEKKNLTLSKEVQQIQSNYDIAI 904
R F+ T+ N LK + NK +V+ Q+++ + L E+ + ++ I I
Sbjct: 353 RDFMETL-NTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRI-I 410
Query: 905 AELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVS-QIKLMHTKIDELRTLDSVSQISN 963
E V+ + E +++ N NN+ +IK M +D LR+ ++Q+ +
Sbjct: 411 DEEGVESINDMFHENAMLQTEN----------NNLRVRIKAMQETVDALRS--RITQLVS 458
Query: 964 IDLLN--LRDLSNGSEE-DNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEA- 1019
D N L G+EE N+ ++ + + + L +K ++ + E R+N ++ A
Sbjct: 459 -DQANHVLARAGEGNEEISNMIHSYIKEIED--LRAKLLESEAVNENLRKNLTRATARAP 515
Query: 1020 -----------IWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEK--- 1065
I KE ++ +E+L+++ ++ + V G +D + +EK
Sbjct: 516 YFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKSVAGKEDNTDTDQEKKEE 575
Query: 1066 ----EHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKA 1121
E +N + ++E + + EE +E+ D+ +G + E + + KA
Sbjct: 576 KGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDI------DGGESSDE-SDSESDEKA 628
Query: 1122 KIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVK 1181
+ + A + +I K+ +I +LE + K Q ++K + +
Sbjct: 629 NYQ-------------ADLANITCEIAIKQKLIDELENSQKRLQ-----TLKKQYEEKLM 670
Query: 1182 ELKLKEEITQLTNN--LQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ 1239
L+ K TQL + LQ++ + EE+ + R E EK +L A + Q L+A
Sbjct: 671 MLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEK---KLQAMNKELQRLQA--- 724
Query: 1240 RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQR 1299
++++A L + + +KQ+K++Q++V M+ + K+ +K + E++K + ++ + R
Sbjct: 725 -AQKEHARLLKNQSQYEKQLKKLQQDVMEMK-KTKVRLMKQMKEEQEKARLTES--RRNR 780
Query: 1300 TIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKL 1359
I QLK K++ D ++ L E ++ Q+ VL K
Sbjct: 781 EIAQLK------------------------KDQRKRDHQLRLLEAQKR--NQEVVLRRKT 814
Query: 1360 EEVERLATELEKWKEKCNDLETKNNQRSNKEHENN------TDVLGKLTNLQDELQESEQ 1413
EEV L ++ +K T+ S+ ++ + T Q +++
Sbjct: 815 EEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVA 874
Query: 1414 KY--------NADRKKWLEE--------------KMMLITQAKEAENIRNKEMKKYAEDR 1451
+ N +RKK+ + K L+ + ++ + D
Sbjct: 875 RVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADM 934
Query: 1452 ERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLK 1511
R KQ+ E+ +L+++ + K E D+ VA + ++++L ++ ++ I +
Sbjct: 935 NRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQ 994
Query: 1512 RII--SETSKIETQIMDI 1527
I E +K E + +D+
Sbjct: 995 ANIMQMEEAKEEGETLDV 1012
>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
Length = 1317
Score = 174 bits (442), Expect = 5e-43
Identities = 249/1089 (22%), Positives = 467/1089 (42%), Gaps = 142/1089 (13%)
Query: 269 FSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYR 328
F VS+ EIYNE + DL SSK LR+ + K +++DL V + +
Sbjct: 144 FRTEVSYLEIYNERVRDLLRRKSSKTFN---LRVREHPKEGPYVEDLSKHLVQNYGDVEE 200
Query: 329 LLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIE-DSEMSRVIRVSELSLCDLAGSERT 387
L+ G +++ A T +N+ SSRSH+IFT+K Q + DSEM VS++ L DLAGSER
Sbjct: 201 LMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEMP-CETVSKIHLVDLAGSERA 259
Query: 388 MKTQNEGERLRETGNINTSLLTLGKCINVL-------KNSEKSKFQQHVPFRESKLTHYF 440
T G RL+E GNIN SL+TLG I+ L N+ K Q VP+R+S LT
Sbjct: 260 DATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLL 319
Query: 441 QSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLN-SSQEKLFGPVKS- 498
+ G K MI IS + Y ETL+ L+++ A+ + T+N + KL +++
Sbjct: 320 KDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAE 379
Query: 499 -SQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENA-----EETQNVETKL 552
++ +L + N L +S E E L ++E V+EL ETQN+
Sbjct: 380 IARLKTLLAQGNQIALLDSPTALSME---EKLQQNEARVQELTKEWTNKWNETQNI---- 432
Query: 553 LDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQY 612
L E +E + E L+ + +DL I + + ++E T Y
Sbjct: 433 LKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGI--------ILYHLKEGQT-----Y 479
Query: 613 WAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATAC 672
+ +A ++ ++ LE IF+++ G + V+ EAT
Sbjct: 480 VGRDDASTEQDIVLHGLDLESEH----CIFENIGGTVTLIPLSGSQCSVNGVQIVEAT-- 533
Query: 673 LELKFNQIKAELAKTKGELIK---TKEELKKRENESDSLIQELETSNKKIITQNQRIKEL 729
NQ A + + + + KE K RE L+ S + + + +
Sbjct: 534 ---HLNQ-GAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAV 589
Query: 730 ------INIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDS 783
+ Q+ + + + ++ + +E + K+D + L E ++ ++
Sbjct: 590 MLYNPGLEFERQQREELEKLESKRKLIEE-MEEKQKSDKAEL---------ERMQQEVET 639
Query: 784 KSKICSERKRVNENELQQDEPPAKKGSIHVSSAITE---DQKKSEEVRPNIAEIEDIRVL 840
+ K + + ++++ E K+ S H+ + + + +++K EE R L
Sbjct: 640 QRK----ETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER-----------L 684
Query: 841 QENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEK-KNLTLSKEVQQIQSN 899
+E E IE + K ++EE ++ + +EL+ +EK + + +E+ Q+Q
Sbjct: 685 REQQE--------IELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKE 736
Query: 900 YDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTK--IDELRTLDS 957
D A+L ++K + +EQE++ + L +E R + ++ + +E R L+
Sbjct: 737 KDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEG 796
Query: 958 VSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSI 1017
+ + LL +++ G +ED + L ++ + VK ++
Sbjct: 797 IRE----SLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLE------------ 840
Query: 1018 EAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEK 1077
K++V+ +++E ++ +E L+ E D+ +RL EK ++ D+ +
Sbjct: 841 -------KDLVQQKDILKKEVQEEQEILECLKCE----HDKESRLLEKHDESVTDVTEVP 889
Query: 1078 ETL--IQQLKEELQEKNVTLDVQIQH-----VVEGKRALSELTQGVTCYKAKIKELETIL 1130
+ I+ ++ LQ K L +Q+ + E +RA L +G + ++E +
Sbjct: 890 QDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEM 949
Query: 1131 ETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT 1190
E +K E + + L+K + N+ +E ++ K + L +E + +E +
Sbjct: 950 E-EKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRK--KEKEILESREKQQREALE 1006
Query: 1191 QLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKE 1250
+ L+ LQ ++ +KL L++ S L+A L+ ++E +E
Sbjct: 1007 RALARLERRHSALQRHSTLGMEIEEQRQKL-ASLNSGSREQSGLQASLEAEQEALEKDQE 1065
Query: 1251 KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNN 1310
+L +Q+KQ EV D + + LE K S + ++ + L + N
Sbjct: 1066 RLEYEIQQLKQKIYEV------DGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARIN 1119
Query: 1311 QKVEEAIQQ 1319
+EE +Q+
Sbjct: 1120 AYIEEEVQR 1128
Score = 71.2 bits (173), Expect = 8e-12
Identities = 123/590 (20%), Positives = 243/590 (41%), Gaps = 74/590 (12%)
Query: 1013 FHSSIEAIWEECKEIVKASSKKSHQIEELEQ-------QIEKLQAEVKGYKDENNRLKEK 1065
++ +E ++ +E+ K SK+ IEE+E+ ++E++Q EV+ + E ++ +
Sbjct: 592 YNPGLEFERQQREELEKLESKRK-LIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQ 650
Query: 1066 EHKNQDDLLKEKETLIQQLKEELQEKNV----TLDVQIQHVVEGKRALSELTQGVTCYKA 1121
K ++ L + + +LK+ L EK L Q + ++ KR E V
Sbjct: 651 IRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQ 710
Query: 1122 KIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQE--------HLQDSVK 1173
++KEL + +K + Q +++ L+LE+ E QE HL++ ++
Sbjct: 711 RLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLR 770
Query: 1174 NTKDLNVKELKLKEEITQLTNNLQDM----KHLLQLKEEEEETNRQETEKLKEELSASSA 1229
+++ +L + E+ + +D+ + LL++KE + E K +L
Sbjct: 771 EKQEM--IQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEF 828
Query: 1230 RTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMR---DEDKLLRIKINELEKK 1286
+ + L L E+D K+ L KK++++ Q+ + ++ D++ L K +E
Sbjct: 829 KRRQL-VKLVNLEKDLVQQKDIL---KKEVQEEQEILECLKCEHDKESRLLEKHDESVTD 884
Query: 1287 KNQCSQE----------LDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIED 1336
+ Q+ L K+R +Q L + +EE + +E + + +
Sbjct: 885 VTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQ 944
Query: 1337 MRMTLEEQE------QTQVEQDQVLEAKLEEVERLATELEKWKEKCND-LETKNNQ---- 1385
+ +EE+E Q Q Q L+A E +A + EK ++K + LE++ Q
Sbjct: 945 VEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREA 1004
Query: 1386 --RSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKE 1443
R+ E L + + L E++E QK + E+ + + E E +
Sbjct: 1005 LERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKD- 1063
Query: 1444 MKKYAEDRERFFKQQNEMEILTAQLTEKD----------SDLQKWREERDQLVAALEIQL 1493
++R + QQ + +I +KD S E+ LV ++ ++
Sbjct: 1064 -----QERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARI 1118
Query: 1494 KALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTE 1543
A I VQ+ ++ L R+ISE M K + KL+ E
Sbjct: 1119 NAYIEEEVQR--RLQDLHRVISEGCSTSADTMKDNEKLHNGTIQRKLKYE 1166
Score = 68.2 bits (165), Expect = 7e-11
Identities = 111/594 (18%), Positives = 263/594 (44%), Gaps = 74/594 (12%)
Query: 1216 ETEKLKEELSASSARTQNLKADLQRKEED---------YADLKEKLTDAKKQIKQVQKEV 1266
+ K +E LSA L+ + Q++EE +++EK K +++++Q+EV
Sbjct: 578 DLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEV 637
Query: 1267 SVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQ-QYERACK 1325
R E ++++++I + E+ + S ++ K + + KE+ +++ E + + ++ +
Sbjct: 638 ETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQ 697
Query: 1326 DLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQ 1385
+ ++ E+++ E + E+ Q+ +E+++L E ++ K +LE K +
Sbjct: 698 EEETFLRVQEELQRLKELNNNEKAEKFQI----FQELDQLQKEKDEQYAKL-ELEKKRLE 752
Query: 1386 RSNKEHENNTDVLGKLTNLQDELQESEQKYNADRK---KWLEEKMM-------LITQAKE 1435
KE + + +L+++L+E ++ R+ +W+EE+ + + KE
Sbjct: 753 EQEKEQ------VMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKE 806
Query: 1436 AENIRNKEMKKYAEDRERFF----KQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEI 1491
A +++ ++ + + RFF +Q ++ L L ++ L+K +E +++ L+
Sbjct: 807 ARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILECLKC 866
Query: 1492 Q---LKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQT--EPLS 1546
+ L+ + + ++ ++ + + +E + + K +++ + L T E
Sbjct: 867 EHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYR-LQYKERQLQYLLQNHLPTLLEEKQ 925
Query: 1547 TSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPV 1606
+FEI ++ G + LD+ E + E E Q Q N ++ T
Sbjct: 926 RAFEI----LDRGPLSLDNTLYQVEKEME------EKEEQLAQYQANANQLQKLQATFEF 975
Query: 1607 TVKIPKARKRKSNEMEEDLVKCENK--KNATPRTNLKFPISDDRNSSVKKEQKVA--IRP 1662
T I + ++ K + E+++++ K + A R + + R+S++++ + I
Sbjct: 976 TANIAR-QEEKVRKKEKEILESREKQQREALERALARL---ERRHSALQRHSTLGMEIEE 1031
Query: 1663 SSKKTYSLRS-QASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLS 1721
+K SL S G+ + + ++ L+K + L++ +Q +KI E +
Sbjct: 1032 QRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYE---IQQLKQKIYE------VD 1082
Query: 1722 NVEASKENVSQPKRAKRKLYTSEISSPIDISGQVILMDQKMKESDHQIIKRRLR 1775
V+ + K A L S S + V LMD ++ + ++RRL+
Sbjct: 1083 GVQKDHHGTLEGKVASSSLPVSAEKSHL-----VPLMDARINAYIEEEVQRRLQ 1131
Score = 65.1 bits (157), Expect = 6e-10
Identities = 45/166 (27%), Positives = 82/166 (49%), Gaps = 8/166 (4%)
Query: 59 LQVCLRIRPFTQSEKELESEGCVHILDSQTVV--LKEPQCILGRLSEKSSGQMAQKFSFS 116
++V +R+RP + EK+LE++ + + S+T + LK P+ G + + FSF
Sbjct: 4 VKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSFY 63
Query: 117 KVFGPA---TTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILP 173
+ +Q+ F+ VK +G + +F YG T SGK+YT G + G++P
Sbjct: 64 SADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIP 123
Query: 174 RTLNVLFDSLQERLYTKMNLKPHRSR-EYLRLSSEQEKEEIASKSA 218
R LF + E T+ + R+ YL + +E+ ++ + KS+
Sbjct: 124 RICEGLFSRINET--TRWDEASFRTEVSYLEIYNERVRDLLRRKSS 167
Score = 63.5 bits (153), Expect = 2e-09
Identities = 115/637 (18%), Positives = 265/637 (41%), Gaps = 102/637 (16%)
Query: 485 LNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEE 544
L+ S+E L + + + + ++ ++ E E D+ +E ++ E
Sbjct: 579 LSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVE 638
Query: 545 TQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREE 604
TQ ET+++ + K E K H E KL DL+ + +K +E+ +E + + +
Sbjct: 639 TQRKETEIVQLQIRKQEESLKRRSFHIE-NKLKDLLAEKEKFEEERLREQQEIELQKKRQ 697
Query: 605 VTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDL--VGKCDTREEAAKDICAT 662
+ F + +E L + +E+ + IF++L + K + A ++
Sbjct: 698 EEETFLR--------VQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKK 749
Query: 663 KVETEEATACL-------ELKFNQIKAELAKTKGELIKTKEELKKRENESDSLI------ 709
++E +E + +L+ Q +L + +GE+ +EE + E +SL+
Sbjct: 750 RLEEQEKEQVMLVAHLEEQLREKQEMIQLLR-RGEVQWVEEEKRDLEGIRESLLRVKEAR 808
Query: 710 -------QELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHME------NTFKC 756
+ELE + + +R +L+ +++ ++D + + LK ++ KC
Sbjct: 809 AGGDEDGEELEKAQLRFFEFKRR--QLVKLVNLEKDLVQQKDILKKEVQEEQEILECLKC 866
Query: 757 NDKADTSSLIINNKLICNETVEVPKD-SKSKICSERKRVNENELQ---QDEPPAKKGSIH 812
++ L +++ + + T EVP+D K K R + E +LQ Q+ P
Sbjct: 867 EHDKESRLLEKHDESVTDVT-EVPQDFEKIKPVEYRLQYKERQLQYLLQNHLP------- 918
Query: 813 VSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQI 872
+ E+++++ E+ L L+++N L ++E E +Q+
Sbjct: 919 ---TLLEEKQRAFEI-------------------LDRGPLSLDNTLYQVEKEMEEKEEQL 956
Query: 873 VHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETAT 932
+Q + ++Q++Q+ ++ A + Q+ K +++E++I L + +
Sbjct: 957 AQYQAN-----------ANQLQKLQATFEFT-ANIARQEEKVRKKEKEI--LESREKQQR 1002
Query: 933 RSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGND 992
++ +++++ H+ + TL + L L++GS E + L+
Sbjct: 1003 EALERALARLERRHSALQRHSTLGMEIEEQR---QKLASLNSGSREQSGLQASLEAEQEA 1059
Query: 993 YLVSKQVKEYRIQEPNR--------ENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ 1044
++ EY IQ+ + + H ++E + + S++KSH + ++ +
Sbjct: 1060 LEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEG--KVASSSLPVSAEKSHLVPLMDAR 1117
Query: 1045 IEK-LQAEVKGYKDENNRLKEKEHKNQDDLLKEKETL 1080
I ++ EV+ + +R+ + D +K+ E L
Sbjct: 1118 INAYIEEEVQRRLQDLHRVISEGCSTSADTMKDNEKL 1154
>gi|116686122 kinesin family member 4 [Homo sapiens]
Length = 1232
Score = 173 bits (439), Expect = 1e-42
Identities = 232/1016 (22%), Positives = 455/1016 (44%), Gaps = 126/1016 (12%)
Query: 261 LNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQV 320
++ + +F++ VS+ EIYNE I DL P K Q + + +D K I L V
Sbjct: 126 IDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQ----INIREDPKEGIKIVGLTEKTV 181
Query: 321 SDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCD 380
+ + L+ G ++VA T +N+ SSRSH+IFT+ + Q + S+ + R S+L L D
Sbjct: 182 LVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFR-SKLHLVD 240
Query: 381 LAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYF 440
LAGSER KT+ EG+RL+E NIN LL LG I+ L + +K F VP+R+SKLT
Sbjct: 241 LAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGGF---VPYRDSKLTRLL 297
Query: 441 QSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLN-----SSQEKLFGP 495
Q G MI +S +ETLN L+++ A+K+ +N + L
Sbjct: 298 QDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNIDPQTAELNHLKQQ 357
Query: 496 VKSSQDVSLDSNSNSKILNVKRATISWENSLEDLME-DEDLVEELEN---------AEET 545
V+ Q + L ++ + ++ T+ +L+ LME ++ LVEE E +
Sbjct: 358 VQQLQVLLLQAHGGTLPGSI---TVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTA 414
Query: 546 QNVE----TKLLDEDLDKTLEENKAFISHE-EKRKLLDLIEDLKKKLINEKKEKLTLEFK 600
Q +E T+ +E ++ LEE + + + + +KL++ +ED E KE + +
Sbjct: 415 QMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLVETLED------QELKENVEIICN 468
Query: 601 IREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDIC 660
+++ +TQ + A A + QE ++
Sbjct: 469 LQQLITQLSDETVACMAAAIDTAVEQEAQV------------------------------ 498
Query: 661 ATKVETEEATACLELKFNQIKAELAKTKGELIKT---KEELKKRENESDSLIQELETSNK 717
T ET ++ + +A+++K EL K KE L ++ ++DS +Q ++ +
Sbjct: 499 ETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQYQ 558
Query: 718 KIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777
I + + E+IN+ +KE+ + E Q K N K +++ + + I +
Sbjct: 559 DNIKELE--LEVINLQKEKEELVLELQTAKKD-ANQAKLSERRRKRLQELEGQ-IADLKK 614
Query: 778 EVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDI 837
++ + SK E ++L Q+ K + + + ED +K + + + +++
Sbjct: 615 KLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQK--KDKEV 672
Query: 838 RVLQENNEGLRAFLLTIE-------NELKNEKEEKAELNKQIVH-FQQELSLSEKKNLTL 889
L+E + + LL +E N L+ + EE A NK++ Q++ +++K+ T
Sbjct: 673 IQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQ 732
Query: 890 SKEVQQIQSNYDIAIA-ELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTK 948
S+ ++ + + E+ V S E+ + N++ + + +V+Q+K K
Sbjct: 733 SRGMEGTAARVKNWLGNEIEVMVS-----TEEAKRHLNDLLEDRKILAQDVAQLK---EK 784
Query: 949 IDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDY-LVSKQVKEYRIQEP 1007
+ + L +R SE ++ Q++ L + S Q+ + +Q+
Sbjct: 785 KESGENPPPKLRRRTFSLTEVR--GQVSESEDSITKQIESLETEMEFRSAQIAD--LQQK 840
Query: 1008 NRENSFHSSIEAIWEECKEIVKASSKKSHQIEEL---EQQIEKLQAEVKGYKD---ENNR 1061
+ + WE I++A + I EL + Q+ KL++ +K K + +
Sbjct: 841 LLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQK 900
Query: 1062 LKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT-----QGV 1116
+ +E + ++ E + + +++++ QEK + L Q+Q ++ L E Q +
Sbjct: 901 MLFEERNHFAEIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAEKQLEESVSEKEQQLL 960
Query: 1117 TCYKAKIKELETILETQKVECSHSAKL--EQDILEKESIILKLERNLKEFQEHLQDSVKN 1174
+ K + +ELE + E C + +L E +I++++ +L++ Q+HL
Sbjct: 961 STLKCQDEELEKMREV----CEQNQQLLRENEIIKQKLTLLQVASR----QKHLPKDTLL 1012
Query: 1175 TKDLNV-------KELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEE 1223
+ D + K ++KE+ + + +++D+K+ + E E + ++ +E
Sbjct: 1013 SPDSSFEYVPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDDDEGDDE 1068
Score = 77.4 bits (189), Expect = 1e-13
Identities = 123/562 (21%), Positives = 246/562 (43%), Gaps = 60/562 (10%)
Query: 1016 SIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEK-EHKNQDDLL 1074
+++++ E+ + +V+ + K S + E Q ++ + + N ++ K E Q
Sbjct: 384 NLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAAC 443
Query: 1075 K-EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQ 1133
K + + L++ L+++ ++NV + +Q ++ LS+ T V C A I +T +E +
Sbjct: 444 KLDLQKLVETLEDQELKENVEIICNLQQLIT---QLSDET--VACMAAAI---DTAVEQE 495
Query: 1134 -KVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQL 1192
+VE S D + + + + + ++ V+ K L +KE L ++TQ
Sbjct: 496 AQVETSPETSRSSDAFTTQHALRQAQMS--------KELVELNKALALKEA-LARKMTQN 546
Query: 1193 TNNLQDMKHLLQLKEEEEETNRQETEKLKEEL---------SASSAR-TQNLKADLQRKE 1242
+ LQ +++ Q +E E +K KEEL A+ A+ ++ + LQ E
Sbjct: 547 DSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQTAKKDANQAKLSERRRKRLQELE 606
Query: 1243 EDYADLKEKLTDAKKQIK----------QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQ 1292
ADLK+KL + K +K ++ +E+ +M+++ L ++ E +K Q Q
Sbjct: 607 GQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQ 666
Query: 1293 ELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQD 1352
+ K + + QLKE+ + ++ E ++ K NV + E+ + + +Q
Sbjct: 667 K---KDKEVIQLKER-DRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQR 722
Query: 1353 QVLEAKLEE----VERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDEL 1408
+V + + E +E A ++ W N++E + K H N+ K+ QD
Sbjct: 723 EVADKRKETQSRGMEGTAARVKNWLG--NEIEVMVSTEEAKRHLNDLLEDRKIL-AQDVA 779
Query: 1409 QESEQKYNADR-KKWLEEKMMLIT----QAKEAENIRNKEMKKYAEDRERFFKQQNEMEI 1463
Q E+K + + L + +T Q E+E+ K+++ + E Q +++
Sbjct: 780 QLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADLQQ 839
Query: 1464 LTAQLTEKDSDLQKWREERDQLVA--ALEIQLKALISSNVQKDNEIEQLKRIISETSKIE 1521
+D Q+W L A AL+ + L+SS +Q LK+ S+TS +
Sbjct: 840 KLLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQ--SKTSCAD 897
Query: 1522 TQIMDIKPKRISSADPDKLQTE 1543
Q M + + + +LQ E
Sbjct: 898 MQKMLFEERNHFAEIETELQAE 919
Score = 70.1 bits (170), Expect = 2e-11
Identities = 49/157 (31%), Positives = 78/157 (49%), Gaps = 26/157 (16%)
Query: 59 LQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKV 118
++V LR RP E SEGC L + V EPQ ++G ++KS F++ V
Sbjct: 10 VRVALRCRPLVPKEI---SEGCQMCL---SFVPGEPQVVVG--TDKS-------FTYDFV 54
Query: 119 FGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQG-------TEENIGI 171
F P+T Q+E F + +K + KG + + YG T SGKTY+ G E +G+
Sbjct: 55 FDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGV 114
Query: 172 LPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQ 208
+PR + +LF + ++ + LK YL + +E+
Sbjct: 115 IPRVIQLLFKEIDKKSDFEFTLKV----SYLEIYNEE 147
>gi|150010604 kinesin family member 4B [Homo sapiens]
Length = 1234
Score = 164 bits (415), Expect = 7e-40
Identities = 222/1002 (22%), Positives = 420/1002 (41%), Gaps = 161/1002 (16%)
Query: 261 LNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQV 320
++ + +F++ VS+ EIYNE I DL P K Q + + +D K I L V
Sbjct: 126 IDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQ----INIREDPKEGIKIVGLTEKTV 181
Query: 321 SDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCD 380
+ + L+ G ++VA T +N+ SSRSH+IFT+ I Q + S+ + R S+L L D
Sbjct: 182 LVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFR-SKLHLVD 240
Query: 381 LAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYF 440
LAGSER KT+ EG+RL+E NIN LL LG I+ L + +K F VP+R+SKLT
Sbjct: 241 LAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSF---VPYRDSKLTRLL 297
Query: 441 QSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLN-----SSQEKLFGP 495
Q G MI +S +ETL+ L+++ A+K+ +N + L
Sbjct: 298 QDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQ 357
Query: 496 VKSSQDVSLDSNSNSKILNVKRATISWENSLEDLME-DEDLVEELEN---------AEET 545
V+ Q + L ++ + ++ +L+ LME ++ LVEE E +
Sbjct: 358 VQQLQVLLLQAHGGTLPGSINAEP---SENLQSLMEKNQSLVEENEKLSRCLSKAAGQTA 414
Query: 546 QNVE----TKLLDEDLDKTLEENKAFISHE-EKRKLLDLIEDLKKKLINEKKEKLTLEFK 600
Q +E T+ ++E L+ LEE + ++ + + +KL++ +ED E KE + +
Sbjct: 415 QMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLED------QELKENVEIICN 468
Query: 601 IREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDIC 660
+++ +TQ + A A + +E ++
Sbjct: 469 LQQLITQLSDETVACTAAAIDTAVEEEAQV------------------------------ 498
Query: 661 ATKVETEEATACLELKFNQIKAELAKTKGEL---IKTKEELKKRENESDSLIQELETSNK 717
T ET ++ + +A+++K EL + KE L ++ ++D+ +Q ++ +
Sbjct: 499 ETSPETSRSSDAFTTQHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQ 558
Query: 718 KIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777
I + E+IN+ +KE+ + E Q K + +N +
Sbjct: 559 DNIKNLE--LEVINLQKEKEELVRELQTAKKN-----------------VNQAKLSEHRH 599
Query: 778 EVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDI 837
++ ++ + +I +K++NE +K + S+ T + E ++ +
Sbjct: 600 KLLQELEGQIADLKKKLNEQ--------SKLLKLKESTERTVSKLNQEIWMMKNQRVQLM 651
Query: 838 RVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ 897
R ++E+ E R + + E+ KE + +++ ++ +K++ L ++ ++
Sbjct: 652 RQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNF---QKQSSVLRRKTEEAA 708
Query: 898 SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDS 957
+ L Q+ +++E I R+ N +I++M + + R L+
Sbjct: 709 AANKRLKDALQKQREVTDKRKETQSHGKEGIAARVRNWLGN--EIEVMVSTEEAKRHLN- 765
Query: 958 VSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSI 1017
DLL R +L D + K+ KE R P + S+
Sbjct: 766 -------DLLEDR----------------KILAQDVVQLKEKKESRENPPPKLRKCTFSL 802
Query: 1018 EAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEK 1077
+ + E +K QIE LE ++E A++ D +L + E +++ E
Sbjct: 803 SEVHGQVLESEDCITK---QIESLETEMELRSAQI---ADLQQKLLDAESEDRPKQCWE- 855
Query: 1078 ETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVEC 1137
I ++E K AL L + K + +LE L K C
Sbjct: 856 --------------------NIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASC 895
Query: 1138 SHSAKLEQDILEKESIILKLERNL-----KEFQEHLQDSVKNTKDLNVKELKLKEEITQL 1192
A +++ + E+++ ++E L + Q+H + + L ++ K+
Sbjct: 896 ---ADMQKMLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSA 952
Query: 1193 TNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNL 1234
+ Q + LQ ++EE E R+ E+ ++ L + Q L
Sbjct: 953 SEKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQKL 994
Score = 100 bits (249), Expect = 1e-20
Identities = 192/888 (21%), Positives = 358/888 (40%), Gaps = 131/888 (14%)
Query: 869 NKQIVHFQQELS-LSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN-QEQEEKIMKLSN 926
NK IV+ + L+ K +V +Q++ ++ + S+N Q EK L
Sbjct: 338 NKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVE 397
Query: 927 EIETATRSITNNVSQIKLM--------------HTKIDELR--------------TLDSV 958
E E +R ++ Q M + K++ELR TL+
Sbjct: 398 ENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQ 457
Query: 959 SQISNIDLL-NLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSI 1017
N++++ NL+ L ++ + T + D V ++ + E +R + ++
Sbjct: 458 ELKENVEIICNLQQLITQLSDETVACTAAAI---DTAVEEEAQVETSPETSRSSDAFTTQ 514
Query: 1018 EAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDD----- 1072
A+ + ++ S ++ EL + +A V+ +N+L+ + + QD+
Sbjct: 515 HALHQ---------AQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLE 565
Query: 1073 -----LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE 1127
L KEKE L+++L + +KNV +H + L EL + K K+ E
Sbjct: 566 LEVINLQKEKEELVREL--QTAKKNVNQAKLSEH---RHKLLQELEGQIADLKKKLNEQS 620
Query: 1128 TILETQKVECSHSAKLEQDILEKESIILKLERNLKE----FQEHLQDSVKNTKDLNVKEL 1183
+L+ ++ +KL Q+I ++ ++L R +KE F++ Q K L ++
Sbjct: 621 KLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDR 680
Query: 1184 KLKEEITQLTNNLQDMKHLLQLKEEEE-----------ETNRQETEKLKEELSAS----S 1228
K + E+ +L N Q +L+ K EE + R+ T+K KE S +
Sbjct: 681 KRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIA 740
Query: 1229 ARTQNLKAD----LQRKEEDYADLKEKLTDAK---KQIKQVQKEVSVMRDEDKLLRIKIN 1281
AR +N + + EE L + L D K + + Q++++ + LR
Sbjct: 741 ARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTF 800
Query: 1282 ELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEA-IQQYERACKDLNVKEKIIEDMRMT 1340
L + Q + D + I+ L+ ++ + + A +QQ + + ++ E++
Sbjct: 801 SLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQKLLDAESEDRPKQCWENIATI 860
Query: 1341 LEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGK 1400
LE + + +++ +K+ V +L L + K C D++ + N E T+
Sbjct: 861 LEAKCALKYLIGELVSSKIH-VTKLENSLRQSKASCADMQKMLFEEQNHFSEIETE---- 915
Query: 1401 LTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNE 1460
LQ EL EQ++ E+ + L++Q +E++ + K+++K A ++E
Sbjct: 916 ---LQAELVRMEQQHQ-------EKVLYLVSQLQESQ-MAEKQLEKSASEKE-------- 956
Query: 1461 MEILTAQLTEKDSDLQKWRE---ERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISET 1517
+ L + L +D +L+K RE + QL+ EI + LI V + ++S
Sbjct: 957 -QQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQKLILLQVASRQKHLPNDTLLSPD 1015
Query: 1518 SKIETQIMDIKPKRISSADPDK-LQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQST 1576
S E KP R+ ++ + E L E S N+ EDG DS E E + T
Sbjct: 1016 SSFEYIPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDGDSDEGDDEEWKPT 1075
Query: 1577 RFPKPELE-IQFTPLQP---NKMA---VKHPGCTTPVTVKIPKARKRKSN---------- 1619
+ K + IQ + NK + C + K R R+
Sbjct: 1076 KLVKVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCSCDPTKCRNRQQGKDSLGTVEQT 1135
Query: 1620 EMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKT 1667
+ E K E+ TP + P+ NS + KE + SKKT
Sbjct: 1136 QDSEGSFKLEDPTEVTPGLSFFNPVCATPNSKILKEMCDMEQVLSKKT 1183
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/157 (31%), Positives = 76/157 (48%), Gaps = 26/157 (16%)
Query: 59 LQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKV 118
++V LR RP E SEGC L + V E Q ++G ++KS F++ V
Sbjct: 10 VRVALRCRPLVPKEI---SEGCQMCL---SFVPGETQVVVG--TDKS-------FTYDFV 54
Query: 119 FGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQG-------TEENIGI 171
F P T Q+E F + +K + KG + + YG T SGKTY+ G E +GI
Sbjct: 55 FDPCTEQEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGI 114
Query: 172 LPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQ 208
+PR + +LF + ++ + LK YL + +E+
Sbjct: 115 IPRVIQLLFKEIDKKSDFEFTLKV----SYLEIYNEE 147
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 163 bits (413), Expect = 1e-39
Identities = 325/1520 (21%), Positives = 641/1520 (42%), Gaps = 240/1520 (15%)
Query: 324 KEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDS--EMSRVIRVSELSLCDL 381
+E ++ L + ++ T+L +A + + K + I ++ +M + + E + L
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 382 AGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQ 441
+ M TQ E R ++ + + L K ++ + +E+++ + E T
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT 447
Query: 442 SFFNGKGKICMIVNISQCYLAYDETLNVLKFS-----AIAQKVCVPDTLNSSQE---KLF 493
S + +I + +S+ E ++V+K S A QK+ + QE KL
Sbjct: 448 S---EEERISLQQELSR---VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ 501
Query: 494 GPVKSSQD---VSLDSNSNSKILNVKRATISWEN-SLEDL--------MEDEDLVEELEN 541
+ Q+ V+L+ S S+ L + + E+ +LE+L E E+ + +L+
Sbjct: 502 TREREFQEQMKVALEK-SQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQ 560
Query: 542 AEETQNVETKLLDEDLDKTLEENK------AFISHEEKRK----LLDLIEDLKKKLINEK 591
ET L+ L+K+L+ENK A EK K + ++E K +L + K
Sbjct: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 592 KEKLTLEFKIREEVTQEF-TQYWAQREA--DFKETLLQEREIL-----EENAERRLAIFK 643
++ L + + + Q++ T+ RE KETLL+++EI+ EE E+ L
Sbjct: 621 HQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLE--- 677
Query: 644 DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGEL-IKTKEELKKRE 702
K D ++ + + + E +A LE + + +K + K K EL K E+ +
Sbjct: 678 ----KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ 733
Query: 703 NESDSLIQELETSNKKIITQ-NQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKAD 761
+ DS+I+E E S ++ +I +L ++ +++ + E Q +H+EN +++
Sbjct: 734 QQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQ---AHVENLEADIKRSE 790
Query: 762 TSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQ 821
+ KL ++ + ++K E+ +LQQ + I ++ + E +
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLA----QLQQKLLDLETERILLTKQVAEVE 846
Query: 822 KKSEEVRPNI----AEIEDI--RVLQENNE---GLRAFLLTIENELKNEKEEKAELNKQI 872
+ ++V + +++D+ ++ ++N+E +++ E++L++ +E+ E KQI
Sbjct: 847 AQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ-EQTKQI 905
Query: 873 VHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETAT 932
L EK+N+ L Q + E+ + K +E+ I L+ E ET
Sbjct: 906 --------LVEKENMILQMREGQKK--------EIEILTQKLSAKEDSIHILNEEYETKF 949
Query: 933 RSITNNVSQIKLMHTKIDEL---RTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLL 989
++ + ++K ++ E + LD +++ +LS ++ N ++
Sbjct: 950 KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM-AQ 1008
Query: 990 GNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQ 1049
N +S V E N++ S E E +++ KK +Q E Q+I ++Q
Sbjct: 1009 ANSAGISDAVSRL---ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ 1065
Query: 1050 AEVKGYKDENNRLK------EKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVV 1103
+ K + + K EKE N++ I LKEE +++ TL+ + +
Sbjct: 1066 LQEKEQEVAELKQKILLFGCEKEEMNKE---------ITWLKEEGVKQDTTLNELQEQLK 1116
Query: 1104 EGKRALSELTQGVTCYKAKIKELE----------TILETQKVECSHSAKLEQDILEKESI 1153
+ ++ L Q T KA +++LE T L+ Q VE A E+D + +
Sbjct: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA--EEDKRKVSEL 1174
Query: 1154 ILKLERNLKEFQEHLQDSVKNTKDLNVKEL---KLKEEIT-QLTNNLQDMKHLLQLKEEE 1209
KL+ +EFQ K+ K L K L KL EE+ QL + + LL+ K E
Sbjct: 1175 TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNE 1234
Query: 1210 ------EETN---------RQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTD 1254
+TN + T K+KE L + L+A L++ E+ L
Sbjct: 1235 LINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQ 1294
Query: 1255 AKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL---------- 1304
A Q+++ + ++ M+ + + L + L+K+ Q K+ I QL
Sbjct: 1295 ATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINA 1354
Query: 1305 ----KEQLNNQKVEEAIQQYERACKDLNV----------KEKIIEDMRMTLEEQEQTQVE 1350
KE+L +KVE I + DLNV KE I +R +E++ ++
Sbjct: 1355 VTLMKEELKEKKVE--ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412
Query: 1351 QDQVLEAK-----------LEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLG 1399
Q Q L K LE+V+ + + +WK+K T+ +Q + KE + ++
Sbjct: 1413 QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQ-HQNTVKELQIQLELKS 1471
Query: 1400 K--------LTNLQDELQESEQKYNA------DRKKWLEEKMMLITQAKEAENIRNKEMK 1445
K + L++EL + ++++ D K +E+K + +++ R E++
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
Query: 1446 KYAEDRERFFKQQNEM--------EILTAQLTEKDSDLQKWREERDQLVAALEIQLKALI 1497
+ + + NE+ +I +L +K Q+ EE+D V E ++ L
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL- 1590
Query: 1498 SSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRIS---SADPDKLQTEPLSTSFEISRN 1554
+N++ +K + ET K E + +++ K A D+L++E + E+ R
Sbjct: 1591 ------ENQVYSMKAEL-ETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR- 1642
Query: 1555 KIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKAR 1614
K E + +S ++ ++ K T +++ K + R
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKG------TESHLSELNTK------------LQER 1684
Query: 1615 KRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQA 1674
+R+ + +EE L E+ ++ T L P S ++ ++++ + +KTY +
Sbjct: 1685 EREVHILEEKLKSVESSQSET----LIVPRSAKNVAAYTEQEEADSQGCVQKTY--EEKI 1738
Query: 1675 SIIGVNLATKKKEGTLQKFG 1694
S++ NL K+K LQ+ G
Sbjct: 1739 SVLQRNLTEKEK--LLQRVG 1756
Score = 162 bits (410), Expect = 3e-39
Identities = 277/1350 (20%), Positives = 580/1350 (42%), Gaps = 170/1350 (12%)
Query: 489 QEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNV 548
+E LF V S + L++ +T S++ + E EDLV ++ + Q +
Sbjct: 81 KESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLI 140
Query: 549 ET-KLLDEDLDKTLEENKAFIS-----HEEKRKLLDLI---EDLKKKLINEKKEKLTLEF 599
+ + ++ L + ++ EK+KL ++ +D + I E +E+L ++
Sbjct: 141 QRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQ 200
Query: 600 KIREEVTQEFTQYWAQREADFKETLLQEREILEE---NAERRLAIFKDLV-----GKCDT 651
+ ++ + +EF +++ + L + +L++ N + + K L + T
Sbjct: 201 QAKKHLQEEFDASLEEKD-QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFT 259
Query: 652 REEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQE 711
+EE + VE + LE ++K + + L + KE ++ + + L E
Sbjct: 260 KEENPESDGEPVVEDGTSVKTLETLQQRVKRQ----ENLLKRCKETIQSHKEQCTLLTSE 315
Query: 712 LETSNKKIITQNQRIKELINIID----QKEDTINEFQNLKSHMENTFKCNDKADTSSLII 767
E +++ ++R++EL I D +K I + ++ K+ +E + D +I
Sbjct: 316 KEALQEQL---DERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQL-----EQDKGMVIA 367
Query: 768 NNKLICNETVEVPKDSKSKICSERKRVNEN--ELQQDEPPAKKGSIHVSSAITEDQKKSE 825
K +ET+E+ ++ +++ S K++ EL++ + +++ + +K+E
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE 427
Query: 826 EVRPNI-AEI-EDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQ----QEL 879
E R + AE+ E I+ +++ +E R ++++ EL K+E ++ K+ Q Q+L
Sbjct: 428 EARRKLKAEMDEQIKTIEKTSEEER---ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL 484
Query: 880 SLSE--KKNLTLSKEVQ----QIQSNYDIAIAELHVQKSK-NQEQEEKIMKLSNEIETAT 932
E +K L+K++Q + Q +A+ + + K +QE+E++ E+E
Sbjct: 485 HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK 544
Query: 933 RSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGND 992
++I ++LR L ++ +L L S ++N
Sbjct: 545 KAILTESE---------NKLRDLQQEAETYRTRILELESSLEKSLQENKNQ--------- 586
Query: 993 YLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ-----IEK 1047
SK + + E N+ N KEI K ++E L+ Q EK
Sbjct: 587 ---SKDLAVHLEAEKNKHN-------------KEITVMVEKHKTELESLKHQQDALWTEK 630
Query: 1048 LQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVT-LDVQIQHVVEGK 1106
LQ + Y+ E +L+EK + ++ LLK+KE + Q EE+ EK + LDV+ +
Sbjct: 631 LQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLS 690
Query: 1107 RALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQE 1166
LSE+ + + K++E ++L+ Q + K++Q+ LE + E +
Sbjct: 691 SELSEVLKA----RHKLEEELSVLKDQ------TDKMKQE----------LEAKMDEQKN 730
Query: 1167 HLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSA 1226
H Q V + + E+ ++ L + + ++ LL+ +++ + ++ E L+ ++
Sbjct: 731 HHQQQVDSI--IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 1227 SSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKK 1286
S Q A L + + E+ ++Q+ Q+Q+++ + E LL ++ E+E +
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
Query: 1287 KNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDL-NVKEKIIEDMRMTLEEQE 1345
K ELD + +Q L +QL Q E E+ K L V E +ED E+ +
Sbjct: 849 KKDVCTELDAHKIQVQDLMQQLEKQNSE-----MEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 1346 QTQVEQD----QVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKL 1401
Q VE++ Q+ E + +E+E L +L ++ + L + + + + V K
Sbjct: 904 QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
Query: 1402 TNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKK-----YAEDRERF-F 1455
+Q+ L++ A KK LE + ++Q ++ N + EM + ++ R
Sbjct: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
Query: 1456 KQQNEMEILTAQLTEKDSDL-----QKWREERDQLVAALEIQLKALISSNVQKDNEIEQL 1510
Q+ ++E LT + +D+ +K ++ ++L EIQL+ +K+ E+ +L
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQ-------EKEQEVAEL 1076
Query: 1511 KRII----SETSKIETQIMDIKPKRI-SSADPDKLQTEPLSTSFEISRNKIEDGSVV--L 1563
K+ I E ++ +I +K + + ++LQ + S ++ ++ + L
Sbjct: 1077 KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL 1136
Query: 1564 DSCEVSTEND--QSTRFPKPELEIQFTPLQPNKMAVKHPG--CTTPVTVKIPKARKRKSN 1619
+ EV ++T + +E++ + + + TT + K+ KSN
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
Query: 1620 EMEEDLVKCENKKNATPRTNLKFPISDDRNSS-VKKEQKVAIRPSSKKTYSLRSQASIIG 1678
+ ED K K + ++ I + + ++ + I SS KT ++ S+ S
Sbjct: 1197 KSLED--KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC- 1253
Query: 1679 VNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKR 1738
+ TK KE L K + S L+++ +++ E ++ +S +A+ + + + K
Sbjct: 1254 QHRTTKVKEALLIK-----TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK- 1307
Query: 1739 KLYTSEISSPIDISGQVILMDQKMKESDHQ 1768
S DI V + KE +Q
Sbjct: 1308 -------SMKADIESLVTEKEALQKEGGNQ 1330
Score = 140 bits (354), Expect = 8e-33
Identities = 217/1061 (20%), Positives = 452/1061 (42%), Gaps = 122/1061 (11%)
Query: 509 NSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKL------LDEDLDKTLE 562
N +I +K + + +L +L E L ++ + ETKL L+ DL+K+L+
Sbjct: 1091 NKEITWLKEEGVKQDTTLNELQEQ--LKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK 1148
Query: 563 ENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKE 622
EN E+ +L L E+ K+K+ +LT + K +E Q + ++
Sbjct: 1149 ENTFL--QEQLVELKMLAEEDKRKV-----SELTSKLKTTDEEFQSLKSSHEKSNKSLED 1201
Query: 623 TLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKA 682
L+ +++ EE LAI D+ C + EA + +T E K N I +
Sbjct: 1202 KSLEFKKLSEE-----LAIQLDI---CCKKTEALLE-----AKTNELINISSSKTNAILS 1248
Query: 683 ELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINE 742
++ + K KE L + L +L ++ T N ++ + +++KE+ I
Sbjct: 1249 RISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308
Query: 743 FQNLKSHMENTFKCNDKADTSSLIINNKLICNE---TVEVPKDSKSKICSERKRVNENEL 799
KAD SL+ + + E + + +S I +K ++EN
Sbjct: 1309 M---------------KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSEN-- 1351
Query: 800 QQDEPPAKKGSIHVSSAITEDQK-KSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENEL 858
I+ + + E+ K K E+ ++ D+ V +N+ L I +
Sbjct: 1352 -----------INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLR 1400
Query: 859 KNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQ--- 915
K EEK EL Q+ Q+LS K TLSKE D + K K Q
Sbjct: 1401 KQYDEEKCELLDQV----QDLSF---KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1453
Query: 916 -EQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDEL-RTLDSVSQISNIDLLNLRDLS 973
+ + + +L ++E ++ QI L+ ++D+ + D + D +
Sbjct: 1454 TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE 1513
Query: 974 NGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIE--AIWEECKEIVKAS 1031
+ E + T + D++ K ++ + E + + IE + ++ + +
Sbjct: 1514 SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG 1573
Query: 1032 SKKSHQIEELEQQIEKLQAEVKGYKDE-NNRLKEKEHKNQDDLLKEKETLIQQLKEELQE 1090
+K ++++E E++I L+ +V K E + KE EH N +K KE ++ L++ L+
Sbjct: 1574 EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS--VKSKEEELKALEDRLES 1631
Query: 1091 KNVTLDVQIQHVVEGKRA------LSELTQGVTCYK----AKIKELETILETQKVECSHS 1140
++ +++ E K A LS++ + YK + + EL T L+ ++ E
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 1141 AKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK 1200
+ + + +S L + R+ K + + +++ K + E+I+ L NL + +
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE--EKISVLQRNLTEKE 1749
Query: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI- 1259
LLQ +E+E +++ + + ++ +A + L+E+L + K+
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 1260 ----KQVQKE-----VSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL---KEQ 1307
+ V+KE + ++ + + L++K+ C Q L+ K + + +++
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTC-QILEQKIKELDSCLVRQKE 1868
Query: 1308 LNNQKVEEAIQQYER--ACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVL---EAKLEEV 1362
++ ++EE +YE+ A + ++ + K E + EE+ ++ + Q ++L EA+ ++
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL 1928
Query: 1363 ERLATELEKWKEKCNDLET---KNNQRSNKEHENNTDVLGKLTN------LQDELQESEQ 1413
E E+ K+K K+ + KEH+ ++L K + ++ E ++ E
Sbjct: 1929 EFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988
Query: 1414 KYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAED--RERFFKQQNEMEILTAQLTEK 1471
K+N+ K+ + E + Q ++ + KE A++ E Q E L ++ EK
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK 2048
Query: 1472 DSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKR 1512
D DL++ + ++++ A E ++ A + ++E+L++
Sbjct: 2049 DDDLKRTAKRYEEILDAREEEMTAKVR---DLQTQLEELQK 2086
Score = 109 bits (273), Expect = 2e-23
Identities = 249/1158 (21%), Positives = 486/1158 (41%), Gaps = 205/1158 (17%)
Query: 484 TLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSL-EDLMEDEDLVEELENA 542
TLN QE+L KS+ SL + ++++ + SL E+ E LVE A
Sbjct: 1107 TLNELQEQL--KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 543 EETQNVETKLLDEDLDKTLEENKAF-ISHEEKRKLLDLIEDLKKKLINE---------KK 592
EE + ++L + L T EE ++ SHE+ K L+ KKL E KK
Sbjct: 1165 EEDKRKVSELTSK-LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK 1223
Query: 593 EKLTLEFKIREEVTQEFTQ---------YWAQREADFKETLL-----------QEREILE 632
+ LE K E + ++ + R KE LL Q R++ E
Sbjct: 1224 TEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTE 1283
Query: 633 ENAERRLAIFKDLVGKCDTREEAAKDICA------TKVET--------EEATACLELKFN 678
E ++ F+ + + +E K + A T+ E ++A + E
Sbjct: 1284 EQNTLNIS-FQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCIT 1342
Query: 679 QIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKI------------------- 719
Q+K EL++ + KEELK+++ E SL ++L N ++
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 720 --------ITQNQRI--------KELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTS 763
+ Q Q + KE I+ ++Q +D N+F K ++ F +
Sbjct: 1403 YDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT-VK 1461
Query: 764 SLIINNKLICNETVEVPKDS---KSKICSERKRVN--ENELQQDEPPAKKGSIHVSSAIT 818
L I +L E E + K ++ + KR + + E++ D+ +K ++
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL----- 1516
Query: 819 EDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEK----AELNKQIVH 874
E + KS+ R I E+ED + Q+ E + ++ LKN ++K EL +++ H
Sbjct: 1517 ETELKSQTAR--IMELED-HITQKTIE-----IESLNEVLKNYNQQKDIEHKELVQKLQH 1568
Query: 875 FQQ-------ELSLSEKKNLTLSKEVQQIQSNYDIAIAEL-HVQKS-KNQEQEEKIMKLS 925
FQ+ + +E+K LTL +V +++ + EL HV S K++E+E K ++
Sbjct: 1569 FQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR 1628
Query: 926 NEIETAT------RSITNNVSQIKL-MHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEE 978
E E+A R ++ IK + ++++E S++ LN + L E
Sbjct: 1629 LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK-LQERERE 1687
Query: 979 DNLPNTQLDLLGNDY----LVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKAS-SK 1033
++ +L + + +V + K E ++ +EE +++ + ++
Sbjct: 1688 VHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE 1747
Query: 1034 KSHQIEELEQQIEKLQA---EVK-GYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQ 1089
K ++ + Q+ E+ + E++ Y++ +L+ E K +D +++I L+EEL+
Sbjct: 1748 KEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHED-----QSMIGHLQEELE 1802
Query: 1090 EKNVTLDVQI-QHV--------VEGKRALSELTQGV---------TCY--KAKIKELETI 1129
EKN + + QHV ++ K+ L + V TC + KIKEL++
Sbjct: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
Query: 1130 LETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEI 1189
L QK H ++E+ + E + + + + L + +NT++ + L + +
Sbjct: 1863 LVRQKEV--HRVEMEELTSKYEKLQALQQMDGRNKPTELLE--ENTEEKSKSHLVQPKLL 1918
Query: 1190 TQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLK 1249
+ + D++ L E E++ +E +L+++L L+++ + ++
Sbjct: 1919 SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRM-----------LRKEHQQELEIL 1967
Query: 1250 EKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309
+K D +++ K Q++ + + L+ + E + Q QEL+M +KE +N
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM------TIKETIN 2021
Query: 1310 N-QKVE-EAIQQYERACKDL--NVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERL 1365
Q+VE E ++ ++ L + EK +D++ T + E+ +++ + AK+ +++
Sbjct: 2022 KAQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ 2080
Query: 1366 ATELE-KWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQD----ELQESEQKYN-ADR 1419
EL+ K+++K E N E T + K T + D E + EQ +N DR
Sbjct: 2081 LEELQKKYQQKLEQEENPGNDNVT-IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
Query: 1420 KKWLEEKMMLITQAK--EAENIRNKEMKKYAEDRERFF------------KQQNEMEILT 1465
K E+ + T + N+ + ++ + E E + + + +++T
Sbjct: 2140 LKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVIT 2199
Query: 1466 AQLTEKDSDLQKWREERD 1483
L D QK E D
Sbjct: 2200 TVLKFPDDQTQKILERED 2217
Score = 81.3 bits (199), Expect = 8e-15
Identities = 192/925 (20%), Positives = 369/925 (39%), Gaps = 143/925 (15%)
Query: 182 SLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSLT 241
S +E T++ + + + L E+ KE+ S+L +Q+ ++ V L
Sbjct: 1335 SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ----------LQ 1384
Query: 242 NSLNISEFEESI----KDYEQANLNMANSIK-FSVWVSFFEIYNEYIYDLFVPVSSKFQK 296
NS+++SE E +I K Y++ + + ++ S V + S+KF +
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Query: 297 RKMLRLSQDVKGYSFIKDLQWIQVSDSKEAY------RLLKLGIKHQSVAFTKLNNASSR 350
K S+ + + +K+LQ SKEAY LLK + Q+ F L
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1504
Query: 351 SHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTL 410
S K +E S+ R+ EL T KT E E L E
Sbjct: 1505 DKSKMEKKESNLETELKSQTARIMELE------DHITQKT-IEIESLNE----------- 1546
Query: 411 GKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVL 470
VLKN + K +H + KL H+ + G+ K + + L + + +
Sbjct: 1547 -----VLKNYNQQKDIEHKELVQ-KLQHFQEL---GEEKDNRVKEAEEKILTLENQVYSM 1597
Query: 471 KFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLM 530
K + + K + +N S + +K+ +D L+S S +K+ +KR E + +
Sbjct: 1598 K-AELETKKKELEHVNLSVKSKEEELKALED-RLESESAAKLAELKRKA---EQKIAAI- 1651
Query: 531 EDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINE 590
+ L+ ++E EE T+ +L+ L +E+ + + ++E+ K + +
Sbjct: 1652 -KKQLLSQMEEKEEQYKKGTESHLSELNTKL---------QEREREVHILEEKLKSVESS 1701
Query: 591 KKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCD 650
+ E L I + Y Q EAD + +++ E ++++ L
Sbjct: 1702 QSETL-----IVPRSAKNVAAYTEQEEAD-------SQGCVQKTYEEKISV---LQRNLT 1746
Query: 651 TREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKE-ELKKRENES--DS 707
+E+ + + K ET + + ++ + LIK + E K+ E++S
Sbjct: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQYQE----------RLIKLEHAEAKQHEDQSMIGH 1796
Query: 708 LIQELETSNKK---IITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSS 764
L +ELE NKK I+ Q+ +KE N Q K ++EN F D
Sbjct: 1797 LQEELEEKNKKYSLIVAQHV----------EKEGGKNNIQ-AKQNLENVFD-----DVQK 1840
Query: 765 LIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKS 824
+ +L C + K+ S C R++ + ++ +E +K + + K +
Sbjct: 1841 TLQEKELTCQILEQKIKELDS--CLVRQK-EVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897
Query: 825 EEVRPNIAEIEDIRVLQEN-NEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSE 883
E + N E ++Q + A +E +L + EK +L K+IV Q++L +
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Query: 884 KKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIK 943
K++ +E++ ++ YD + +K K QEQE+ +K ++ ++ R ++Q K
Sbjct: 1958 KEH---QQELEILKKEYD----QEREEKIK-QEQEDLELKHNSTLKQLMREFNTQLAQ-K 2008
Query: 944 LMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYR 1003
++ T++ ++ +LL S ++ + D + + K Y
Sbjct: 2009 EQELEMTIKETINKAQEV-EAELLE-------SHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
Query: 1004 IQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQ----------IEELEQQIEKLQAEVK 1053
RE + + + + +E+ K +K Q I EL+ Q+ + +
Sbjct: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120
Query: 1054 GYKDENNRLKEKEHKNQDDLLKEKE 1078
K + +E+ H N +D LK+ E
Sbjct: 2121 DSKLKEQEFREQIH-NLEDRLKKYE 2144
>gi|4758650 kinesin family member 5C [Homo sapiens]
Length = 957
Score = 157 bits (398), Expect = 7e-38
Identities = 205/870 (23%), Positives = 388/870 (44%), Gaps = 116/870 (13%)
Query: 262 NMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVS 321
+M +++F + VS+FEIY + I DL + VS + L + +D ++K VS
Sbjct: 122 SMDENLEFHIKVSYFEIYLDKIRDL-LDVS-----KTNLAVHEDKNRVPYVKGCTERFVS 175
Query: 322 DSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDL 381
+E ++ G ++ VA T +N SSRSHSIF + I Q E+ E + + +L L DL
Sbjct: 176 SPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQ-ENVETEKKLS-GKLYLVDL 233
Query: 382 AGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQ 441
AGSE+ KT EG L E NIN SL LG I+ L K+ HVP+R+SK+T Q
Sbjct: 234 AGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKT----HVPYRDSKMTRILQ 289
Query: 442 SFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQD 501
G + +++ S ET + L F A+ + +T++ + E K +
Sbjct: 290 DSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAK--TIKNTVSVNLELTAEEWKKKYE 347
Query: 502 VSLDSNSNSK--ILNVKRATISWENSLEDLMEDEDL-VEELENAEETQNVETKLLDEDLD 558
+ N K I +++ W N E + EDE + ++ +N E N T ++D
Sbjct: 348 KEKEKNKTLKNVIQHLEMELNRWRNG-EAVPEDEQISAKDQKNLEPCDN--TPIID---- 400
Query: 559 KTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEF---TQYWAQ 615
+ A IS EEK K + I L ++L ++K +++ + ++ E++ Q+ + A
Sbjct: 401 -NIAPVVAGISTEEKEKYDEEISSLYRQL-DDKDDEINQQSQLAEKLKQQMLDQDELLAS 458
Query: 616 READFKE-----TLLQ-EREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEA 669
D+++ T LQ E E ++ + L ++L D + + E E+
Sbjct: 459 TRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQ----------EVEDK 508
Query: 670 TACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQ--NQRIK 727
T E Q+ ELA+ L T+ EL S +QEL KK T+ N +K
Sbjct: 509 TRANE----QLTDELAQKTTTLTTTQREL--------SQLQELSNHQKKRATEILNLLLK 556
Query: 728 EL-----------------INIIDQKEDTINE--FQNLKSHMENTFKCNDKADTSSLIIN 768
+L +N + ++E T+ +KS +++ + + +++ + N
Sbjct: 557 DLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSN 616
Query: 769 NKLICNETVEVP-----KDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKK 823
K+ +E ++KI S + E ++ + + S+ A Q+K
Sbjct: 617 RKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEK 676
Query: 824 SEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSE 883
EV E E + LQ+ E +A +E+ + +++ + L +I Q+ +
Sbjct: 677 MHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIR 736
Query: 884 KKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIK 943
N L E +++ S+Y+ +L ++ + + + EK++ L+++ E A +
Sbjct: 737 DLNQKLQLEQEKLSSDYN----KLKIEDQEREMKLEKLLLLNDKREQAREDLKG------ 786
Query: 944 LMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYR 1003
L T EL+TL N+ L ++DL+ ++ + +LD ND ++ +
Sbjct: 787 LEETVSRELQTL------HNLRKLFVQDLTTRVKK----SVELD---NDDGGGSAAQKQK 833
Query: 1004 IQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLK 1063
I + +++E + + K++V+ ++ ++ +LE+++ VK + K
Sbjct: 834 I------SFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAK 887
Query: 1064 EKEHKNQDDLLKEKETLIQQLKEELQEKNV 1093
E +++ K + + ++KE ++ KN+
Sbjct: 888 ENAMRDR----KRYQQEVDRIKEAVRAKNM 913
Score = 63.9 bits (154), Expect = 1e-09
Identities = 105/461 (22%), Positives = 202/461 (43%), Gaps = 72/461 (15%)
Query: 1120 KAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEH--LQDSVKNTKD 1177
K K K L+ +++ ++E + E + E E I K ++NL+ + +
Sbjct: 350 KEKNKTLKNVIQHLEMELNRWRNGEA-VPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAG 408
Query: 1178 LNVKEL-KLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKA 1236
++ +E K EEI+ L L D K++E Q EKLK+++ L A
Sbjct: 409 ISTEEKEKYDEEISSLYRQLDD-------KDDEINQQSQLAEKLKQQMLDQD----ELLA 457
Query: 1237 DLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDM 1296
+R DY ++E+LT ++Q E +DE K + + EL +Q SQE++
Sbjct: 458 STRR---DYEKIQEELT-------RLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVED 507
Query: 1297 KQRTIQQLKEQLN-------------NQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE 1343
K R +QL ++L +Q E + Q +RA + LN+ K + ++ +
Sbjct: 508 KTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGT 567
Query: 1344 QE-QTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLG--- 1399
+ +T + + V+E EE + K K + L ++ Q + + ++N +
Sbjct: 568 NDVKTLADVNGVIE---EEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASER 624
Query: 1400 KLTNLQDELQESEQKYNA--DRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQ 1457
+L Q + + E K + D + +E+K Q +E+++ ++E+ K +
Sbjct: 625 ELAACQLLISQHEAKIKSLTDYMQNMEQKR---RQLEESQDSLSEELAK--------LRA 673
Query: 1458 QNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISET 1517
Q +M ++ Q +K+ + ++ +++ ALE Q++ S ++ +L+ I E
Sbjct: 674 QEKMHEVSFQ--DKEKEHLTRLQDAEEMKKALEQQME---SHREAHQKQLSRLRDEIEEK 728
Query: 1518 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIED 1558
KI +I D+ KLQ E S + ++ KIED
Sbjct: 729 QKIIDEIRDLN---------QKLQLEQEKLSSDYNKLKIED 760
Score = 49.3 bits (116), Expect = 3e-05
Identities = 118/650 (18%), Positives = 259/650 (39%), Gaps = 116/650 (17%)
Query: 841 QENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNY 900
+E N+ L+ + +E EL + N + V +++S ++KNL I +
Sbjct: 350 KEKNKTLKNVIQHLEMELNRWR------NGEAVPEDEQISAKDQKNLEPCDNTPIIDN-- 401
Query: 901 DIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQI--KLMHTKIDELRTLDSV 958
IA + + ++ +E+I L +++ I N SQ+ KL +D+ L S
Sbjct: 402 -IAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEI-NQQSQLAEKLKQQMLDQDELLAST 459
Query: 959 SQISNI--DLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1016
+ + L + N + +D + L + V+ K +++ R N
Sbjct: 460 RRDYEKIQEELTRLQIENEAAKDEVKEVLQAL--EELAVNYDQKSQEVEDKTRAN----- 512
Query: 1017 IEAIWEECKE---IVKASSKKSHQIEELEQQIEKLQAE--------------------VK 1053
E + +E + + + ++ Q++EL +K E VK
Sbjct: 513 -EQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVK 571
Query: 1054 GYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT 1113
D N ++E+ + + K K + + Q ++ +D + + +R L+
Sbjct: 572 TLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSN-RKMNASERELAACQ 630
Query: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEF------QEH 1167
++ ++AKIK L ++ + + + QD L +E L+ + + E +EH
Sbjct: 631 LLISQHEAKIKSLTDYMQNMEQK-RRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEH 689
Query: 1168 ---LQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEEL 1224
LQD+ +E+K K L Q E E ++++ +L++E+
Sbjct: 690 LTRLQDA---------EEMK---------------KALEQQMESHREAHQKQLSRLRDEI 725
Query: 1225 SASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELE 1284
+ Q+ ++ DL +KL ++++ ++ + E ++ K+ L
Sbjct: 726 E-----------EKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLN 774
Query: 1285 KKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ 1344
K+ Q ++L + T+ + + L+N + + +DL + K ++
Sbjct: 775 DKREQAREDLKGLEETVSRELQTLHNLR--------KLFVQDLTTRVKKSVELDNDDGGG 826
Query: 1345 EQTQVEQDQVLEAKLEEVERLATEL--EKWKEKCNDLETKNNQRSNKEHENNTDVLGKLT 1402
Q ++ LE LE++ ++ +L + +C + + R+ E ++
Sbjct: 827 SAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAE---------RVK 877
Query: 1403 NLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRE 1452
L+ L+E+++ DRK++ +E + + KEA +R K M + A +
Sbjct: 878 ALESALKEAKENAMRDRKRYQQE----VDRIKEA--VRAKNMARRAHSAQ 921
Score = 38.9 bits (89), Expect = 0.045
Identities = 82/385 (21%), Positives = 156/385 (40%), Gaps = 50/385 (12%)
Query: 1257 KQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEA 1316
++ K ++ VSV L + E +KK + ++ + IQ L+ +LN + EA
Sbjct: 322 QRAKTIKNTVSVN------LELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEA 375
Query: 1317 IQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQD---QVLEAKLEEVERLATELEKWK 1373
+ + E+I + LE + T + + V EE E+ E+
Sbjct: 376 VPE----------DEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLY 425
Query: 1374 EKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQA 1433
+ +D + + NQ+S + +L QDEL S ++ D +K ++E++ +
Sbjct: 426 RQLDDKDDEINQQSQLAEKLKQQMLD-----QDELLASTRR---DYEK-IQEELTRLQIE 476
Query: 1434 KEAENIRNKEMKKYAEDRERFFKQQNE--------MEILTAQLTEKDSDLQKWREERDQL 1485
EA KE+ + E+ + Q+++ E LT +L +K + L + E QL
Sbjct: 477 NEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQL 536
Query: 1486 VAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPL 1545
SN QK E L ++ + +I I K ++ + ++ E
Sbjct: 537 QEL----------SNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVN-GVIEEEFT 585
Query: 1546 STSFEISRNKIEDGSVVLDSCEV-STENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTT 1604
IS+ K E S+V S ++ S + D + + E E+ L ++ K T
Sbjct: 586 MARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTD 645
Query: 1605 PVTVKIPKARKRKSNE--MEEDLVK 1627
+ K R+ + ++ + E+L K
Sbjct: 646 YMQNMEQKRRQLEESQDSLSEELAK 670
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 154 bits (390), Expect = 6e-37
Identities = 277/1319 (21%), Positives = 570/1319 (43%), Gaps = 188/1319 (14%)
Query: 466 TLNVLKFSAIAQKVCVPDTLNS--SQEKLFGPVKSSQDVSLDSNSNSKI-LNVKRATISW 522
T++V S+ +C P + S S ++LF ++ D DS + L +KR ++
Sbjct: 29 TVDVNNESSSEGFIC-PQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTL 87
Query: 523 -ENSLEDLMED--------EDLVEELENAEETQNVETK----LLD-----EDLDKTLEEN 564
++DL E+L +ELE + Q E K + D + L++ LEE
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE- 146
Query: 565 KAFISHEEKRKLLDLIEDLKKKLINEK---KEKLTLEFKIREEVTQEFTQYWAQ--REA- 618
A + +++ DL E +L E K K E +RE Q+ T+ + +EA
Sbjct: 147 -AQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEAT 205
Query: 619 ---DFKETLLQ-----EREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEAT 670
D K LLQ + +L++ + + ++ + + E KD C K++++ A+
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK-KLQSQYAS 264
Query: 671 ACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELI 730
+ E +Q+++ELAK E+ +EL+K ++ + L Q+ +T + ++ + Q +L
Sbjct: 265 S--EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL- 321
Query: 731 NIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNET----VEVPKDSKSK 786
E+ NE K +++ T + D + ++L +ET + V K +
Sbjct: 322 ------EEKHNEESVSKKNIQATLH---QKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 787 ICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEG 846
+ K EL + E + H+ + + Q++ EE E +++ E N+
Sbjct: 373 ATQKLKE----ELSEVETKYQ----HLKAEFKQLQQQREE-----KEQHGLQLQSEINQ- 418
Query: 847 LRAFLLTIENELKNE----KEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDI 902
L + LL E +L KE++ +++++ +Q+++ + K L +++++ +N
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS-- 476
Query: 903 AIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQI-KLMHTKIDELRTLDSVSQI 961
EL Q K ++Q ++ L R N++ Q+ + + K +++ L+++ Q
Sbjct: 477 --TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
Query: 962 S--NIDLLNLR------DLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSF 1013
S NI LL + G E + N L ++ + +QV + + N+ S
Sbjct: 535 SKENISLLEKEREDLYAKIQAGEGETAVLN---QLQEKNHTLQEQVTQLTEKLKNQSESH 591
Query: 1014 HSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDL 1073
+ E + ++ +E +K+H + + ++ L+ V + N KEK + D
Sbjct: 592 KQAQENLHDQVQE------QKAH-LRAAQDRVLSLETSVNELNSQLNESKEKVSQ-LDIQ 643
Query: 1074 LKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQ 1133
+K K L+ L E + D+Q H+ + AL + Q + ++ ++ L+ +
Sbjct: 644 IKAKTELL--LSAEAAKTAQRADLQ-NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK 700
Query: 1134 KVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQL- 1192
+ CS +LE +LKE++E + T++L + KL+ + ++
Sbjct: 701 QEHCS-----------------QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
Query: 1193 TNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKL 1252
+ Q ++ L Q ++ + + TE L ++L + + DLQ+K E +K+KL
Sbjct: 744 ASKEQALQDLQQQRQLNTDLELRATE-LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 1253 TDAKKQIKQVQKEVSVMRDEDKL--------LRIKINELEK---KKNQCSQELDMKQRTI 1301
T +++ + ++++ + E K+ ++ + EL+K +K EL + +
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 1302 QQLKEQL---------NNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQD 1352
++ + L NQK + AI E+ CK+L K ++ M TL+EQ+ E
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL--KHQLQVQMENTLKEQK----ELK 916
Query: 1353 QVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESE 1412
+ LE + E +L EL +E+ ++ +N + N++ E N+ + Q SE
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQL--IQAQNTLKQNEKEEQQLQ-----GNINELKQSSE 969
Query: 1413 QKYNADRKKWLE----EKMMLITQAKEAENIRNKEMKKYAED-----------RERFFKQ 1457
QK KK +E E + + Q E EN +++ + A++ + + K
Sbjct: 970 QK-----KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS 1024
Query: 1458 QNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDN------EIEQLK 1511
Q + L + ++S+L R++ + L + + LIS+ Q N E++ K
Sbjct: 1025 QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK 1084
Query: 1512 RIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTE 1571
+ + S + Q + + K + +K E + + +IE+ + + T+
Sbjct: 1085 ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE--IKCRQEKEITK 1142
Query: 1572 NDQSTRFPKPELEIQFTPLQPNKMAV---KHPGCTTPVTVKIPKARKRKSNEMEEDLVKC 1628
++ + K E + T L+ K + K ++K +++++ ++ +D VK
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 1629 ENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKE 1687
E ++ +F + + S KE++V ++ + L Q + + NL T KKE
Sbjct: 1203 EEEE-----LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE 1256
Score = 112 bits (281), Expect = 2e-24
Identities = 176/821 (21%), Positives = 329/821 (40%), Gaps = 209/821 (25%)
Query: 484 TLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAE 543
+L E+L G +K + SL+ ++ E +L+DL + L
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASK------------EQALQDLQQQRQL-------- 759
Query: 544 ETQNVETKLLDEDLDKTLEENKAFISHE--EKRKLLDLIEDLKKKLINEKKEKLTLEFKI 601
N + +L +L K LE K +S + +K + +E +K+KL +++EK L+
Sbjct: 760 ---NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK--- 813
Query: 602 REEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICA 661
Q+F ETL QE +I E R+ + ++
Sbjct: 814 -----QDF------------ETLSQETKIQHEELNNRI-------------QTTVTELQK 843
Query: 662 TKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIIT 721
K+E E L + + +K +L+K L +K E +K + + I +LE + K++
Sbjct: 844 VKMEKE----ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 722 QNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPK 781
Q Q Q E+T+ E + LK +E
Sbjct: 900 QLQV---------QMENTLKEQKELKKSLE------------------------------ 920
Query: 782 DSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQ 841
K K S + ++ N +Q+ I + + +++K+ ++++ NI E L+
Sbjct: 921 --KEKEASHQLKLELNSMQEQ-------LIQAQNTLKQNEKEEQQLQGNINE------LK 965
Query: 842 ENNEGLRAFLLTIENELKNEKEEKAELN----KQIVHFQQELSLSEKKNLTLSKEVQQIQ 897
+++E + + ++ ELK +K EL +Q+ QEL+ ++K L ++ Q
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025
Query: 898 SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDS 957
+ ++ + ++S+ + + + ++ A + +N +QI + I EL+T +
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
Query: 958 VSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSI 1017
E+D+ Q Q + +Q+ +E S
Sbjct: 1086 TL-----------------EQDSAKKEQ----------QLQERCKALQDIQKEKSLKE-- 1116
Query: 1018 EAIWEECKEIVKASSKKSHQIEEL----EQQIEKLQAEVKGYKDENNRLKEKEHKNQDDL 1073
KE+V SK + +IEE+ E++I KL E+K +K E+ KE N
Sbjct: 1117 -------KELVNEKSKLA-EIEEIKCRQEKEITKLNEELKSHKLESI----KEITN---- 1160
Query: 1074 LKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQ 1133
LK+ + L+ Q K ELQ K +L ++ ++ L K ++K+ E L+ +
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL----------KDQVKKEEEELKKE 1210
Query: 1134 KVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT 1193
+E AKL +I EKE + K E N E KL +IT L
Sbjct: 1211 FIE--KEAKLHSEIKEKEVGMKKHEEN---------------------EAKLTMQITALN 1247
Query: 1194 NNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQN----LKADLQR---KEEDYA 1246
NL +K Q + ++T+ L+ E++ A QN +A L+R E +
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307
Query: 1247 DLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKK 1287
L+ K+ + ++++ V + E++ L+IK + +K
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRK 1348
Score = 105 bits (262), Expect = 4e-22
Identities = 175/873 (20%), Positives = 365/873 (41%), Gaps = 107/873 (12%)
Query: 535 LVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKL-LDLIEDLKKKLINEKKE 593
L E+L+N E+ K E+L ++E KA + + R L L+ + +NE KE
Sbjct: 580 LTEKLKNQSESH----KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE 635
Query: 594 K---LTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDL---VG 647
K L ++ K + E+ + AD + L + L++ + I L
Sbjct: 636 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Query: 648 KCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIK---TKEELKKRENE 704
K ++E + + E +E LE K +++ ++ K + + ++ +KE+ + +
Sbjct: 696 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755
Query: 705 SDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSS 764
L +LE ++ Q + KE+++ T + Q +E+ + K +
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVS------STRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 765 LIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKS 824
I+ ET+ + + + R + ELQ+ + + +S+ + K S
Sbjct: 810 QILKQDF---ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
Query: 825 EEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEK 884
+ ++ + +E E +EN +G +A +L +E K K + + Q E +L E+
Sbjct: 867 DSLKNSKSEFE-----KENQKG-KAAILDLEKTCKELKHQ--------LQVQMENTLKEQ 912
Query: 885 KNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKL 944
K L S E ++ S+ +L ++ + QEQ + + E + + N++++K
Sbjct: 913 KELKKSLEKEKEASH------QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK- 965
Query: 945 MHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRI 1004
+ + + ++++ I +L +L N ++ QL + K+
Sbjct: 966 -QSSEQKKKQIEALQGELKIAVLQKTELENKLQQ------QLTQAAQELAAEKEKISVL- 1017
Query: 1005 QEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKE 1064
+N++ S E + + S+ ++L+ EKL + N++
Sbjct: 1018 -----QNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG- 1071
Query: 1065 KEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIK 1124
NQ+ L++E +T L+++ +K L + + + + ++ S + + K+K+
Sbjct: 1072 ----NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 1125 ELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELK 1184
E+E I Q+ E + KL +++ + +K NLK+ ++ L ++ +L K
Sbjct: 1128 EIEEIKCRQEKEIT---KLNEELKSHKLESIKEITNLKDAKQLL---IQQKLELQGKADS 1181
Query: 1185 LKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 1244
LK + Q N Q +K Q+K+EEEE ++ EK L ++++ KE
Sbjct: 1182 LKAAVEQEKRNQQILKD--QVKKEEEELKKEFIEK-----------EAKLHSEIKEKEVG 1228
Query: 1245 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1304
+E QI + + + ++ E + + +++ELEK+ + E+ + + T+Q
Sbjct: 1229 MKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ-- 1286
Query: 1305 KEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVER 1364
NNQ A+ ER K EK+ QT+V + L+ KL+
Sbjct: 1287 ----NNQDERRAL--LERCLKGEGEIEKL------------QTKVLE---LQRKLDNTTA 1325
Query: 1365 LATELEKWKEKCNDLETKNNQRSNKEHENNTDV 1397
EL + + L+ K+ Q N++ + +V
Sbjct: 1326 AVQELGRENQ---SLQIKHTQALNRKWAEDNEV 1355
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 152 bits (384), Expect = 3e-36
Identities = 225/1049 (21%), Positives = 438/1049 (41%), Gaps = 165/1049 (15%)
Query: 539 LENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLE 598
L++AE + + T + E+ KT +E E KRK +L++K++ KEK L+
Sbjct: 843 LKSAETEKEMAT--MKEEFQKTKDE---LAKSEAKRK------ELEEKMVTLLKEKNDLQ 891
Query: 599 FKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKD 658
++ Q EAD + E L +N + A K++ + + EE +
Sbjct: 892 LQV-------------QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE 938
Query: 659 ICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKK 718
+ A K + E+ + L+ + ++ LAK + E T+ ++K E L + + +K+
Sbjct: 939 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKE 998
Query: 719 IITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICN-ETV 777
+ ++ ++ + +ED +N K+ +E + SL KL + E
Sbjct: 999 KKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLE----GSLEQEKKLRMDLERA 1054
Query: 778 EVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDI 837
+ + K+ E EN+ QQ + +K +S+ I++ IED
Sbjct: 1055 KRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISK--------------IEDE 1100
Query: 838 RVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ 897
+ ++ + ++ ++K + EL ++I + + +EK+ LS+E+++I
Sbjct: 1101 QAVE----------IQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEIS 1150
Query: 898 SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDS 957
+ A Q N+++E + KL ++E AT V+ ++ H DS
Sbjct: 1151 ERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHA--------DS 1202
Query: 958 VSQI-SNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1016
++++ ID L E+ L DL N +SK + +
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK-----------AKGNLEKM 1251
Query: 1017 IEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYK---DENNRLKEKEHKNQDDL 1073
++ ++ E+ ++ I +L Q +LQ E Y DE + L + +++
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 1074 LKEKETLIQQLKEELQEKNV-------------TLDVQIQHVVEGK----RALSELTQGV 1116
++ E L QL+EE + KN L Q + EGK RALS+ V
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1371
Query: 1117 TCYKAKIKELETILETQKVECSHSAKLEQDILEKESII-------LKLERNLKEFQEHLQ 1169
++ K E + I T+++E KL Q + E E + LE+ + Q ++
Sbjct: 1372 AQWRTKY-ETDAIQRTEELE-EAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVE 1429
Query: 1170 DSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEEL----- 1224
D + + + N L ++ L + K + + E E +++E+ L EL
Sbjct: 1430 DLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKN 1489
Query: 1225 --SASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQK------------------ 1264
S + + L+ + + +++ +DL E++ + KQI +++K
Sbjct: 1490 VYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEE 1549
Query: 1265 -EVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQ-YER 1322
E S+ +E K+LRI++ EL + K++ +++ K I QLK N+ +V E +Q +
Sbjct: 1550 AEASLEHEEGKILRIQL-ELNQVKSEVDRKIAEKDEEIDQLKR--NHTRVVETMQSTLDA 1606
Query: 1323 ACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETK 1382
+ N ++ + M L E +E +L RLA E + +
Sbjct: 1607 EIRSRNDALRVKKKMEGDLNE-----------MEIQLNHANRLAAESLR--------NYR 1647
Query: 1383 NNQRSNKEHE-NNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRN 1441
N Q KE + + D L +L+++L E++ N + + +EE + Q + + I
Sbjct: 1648 NTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAE-IEELWATLEQTERSRKIAE 1706
Query: 1442 KEMKKYAEDRERFFKQQNEMEILTAQLTEKD-SDLQKWREERDQLVAALEIQLK------ 1494
+E+ A +R + QN I T + E D S LQ EE Q E + K
Sbjct: 1707 QELLD-ASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDA 1765
Query: 1495 ALISSNVQKDNE----IEQLKRIISETSK 1519
A+++ ++K+ + +E++K+ + +T K
Sbjct: 1766 AMMAEELKKEQDTSAHLERMKKNLEQTVK 1794
Score = 129 bits (323), Expect = 3e-29
Identities = 188/945 (19%), Positives = 415/945 (43%), Gaps = 109/945 (11%)
Query: 485 LNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWE-NSLEDLMEDEDLVEELENAE 543
L ++ KL G +K +Q+ ++D ++ + L+ K +E ++L +EDE VE ++ +
Sbjct: 1051 LERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVE-IQLQK 1109
Query: 544 ETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIRE 603
+ + ++ ++ E+L + +E +A + EK++ DL +L++ I+E+ E+ +
Sbjct: 1110 KIKELQARI--EELGEEIEAERASRAKAEKQRS-DLSRELEE--ISERLEEAGGATSAQV 1164
Query: 604 EVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDT----REEAAKDI 659
E+ ++ + + D +E LQ ++ ++ +L + D +++ K+
Sbjct: 1165 ELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEK 1224
Query: 660 CATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKI 719
K+ET++ ++ E ++ K L K L ELK +E E LI +L ++
Sbjct: 1225 SELKMETDDLSSNAEA-ISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARL 1283
Query: 720 ITQ----NQRIKELINIIDQ----KEDTINEFQNLKSHMENTFKC-NDKADTSSLIINNK 770
T+ ++++ E ++ Q K+ + + + LK +E K N A ++
Sbjct: 1284 QTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDC 1343
Query: 771 LICNETVEVPKDSKSKICSERKRVN----------ENELQQDEPPAKKGSIHVSSAITED 820
+ E E ++ K+++ + N E + Q ++ ++ + E
Sbjct: 1344 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1403
Query: 821 QKKSEEVRPNIAEIEDIRVLQENN--------EGLRAFLLTIENELKNEKEEKAELNKQI 872
++ E V A +E + +N E A ++ + +N + +E ++
Sbjct: 1404 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKY 1463
Query: 873 VHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETAT 932
Q EL S+K++ +LS E+ ++++ Y+ ++ +L + +N+ +++I L+ +I
Sbjct: 1464 EETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGG 1523
Query: 933 RSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGND 992
+ I K + + E++ L + S EE + QL+L
Sbjct: 1524 KQIHELEKIKKQVEQEKCEIQAA-----------LEEAEASLEHEEGKILRIQLELNQVK 1572
Query: 993 YLVSKQV--KEYRIQEPNRENS-----FHSSIEAIWEECKEIVKASSKKSHQIEELEQQI 1045
V +++ K+ I + R ++ S+++A + ++ K + E+E Q+
Sbjct: 1573 SEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQL 1632
Query: 1046 E---KLQAE-VKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQH 1101
+L AE ++ Y++ LKE + + DD L+ +E L +QL + E+ L +Q
Sbjct: 1633 NHANRLAAESLRNYRNTQGILKETQ-LHLDDALRGQEDLKEQLA--IVERRANL---LQA 1686
Query: 1102 VVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNL 1161
+E A E T+ KI E E + +++V+ H+ +K KLE ++
Sbjct: 1687 EIEELWATLEQTER----SRKIAEQELLDASERVQLLHTQNTSLINTKK-----KLENDV 1737
Query: 1162 KEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK 1221
+ Q +++ ++ +++ E K K+ IT +++K +E+ E++K
Sbjct: 1738 SQLQSEVEEVIQESRNA---EEKAKKAITDAAMMAEELK--------KEQDTSAHLERMK 1786
Query: 1222 EELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKIN 1281
+ L Q +K DLQ + ++ L L KKQI++++ V + E +
Sbjct: 1787 KNLE------QTVK-DLQHRLDEAEQLA--LKGGKKQIQKLEARVRELEGE-------VE 1830
Query: 1282 ELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTL 1341
+K+ + + L +R +++L Q + + + + + L K K +
Sbjct: 1831 NEQKRNAEAVKGLRKHERRVKELTYQTEEDR--KNVLRLQDLVDKLQAKVKSYKRQAEEA 1888
Query: 1342 EEQEQTQVEQDQVLEAKLEEVERLA----TELEKWKEKCNDLETK 1382
EEQ + + + L+ +LEE E A +++ K + K ++ TK
Sbjct: 1889 EEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTK 1933
Score = 115 bits (289), Expect = 3e-25
Identities = 193/966 (19%), Positives = 413/966 (42%), Gaps = 112/966 (11%)
Query: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
E E+ KEE + ++ + + E+K +TL KE +Q L +
Sbjct: 849 EKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL----ADA 904
Query: 915 QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKID--ELRTLDSVSQIS-NIDLLNLR- 970
+E+ E+++K ++E + +T + + ++ ++ + + D S++ +ID L L
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 971 ---DLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEI 1027
+ + E+ + N ++ G D ++K KE + + + + ++A ++ +
Sbjct: 965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL-DDLQAEEDKVNIL 1023
Query: 1028 VKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEE 1087
KA +K Q+++LE +E+ + +++ + R E + K + + E QQL E+
Sbjct: 1024 TKAKTKLEQQVDDLEGSLEQ-EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 1088 LQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDI 1147
L++K + I + + + +L + + +A+I+EL +E ++ + + K D+
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 1148 L-EKESIILKLER-----------NLK---EFQEHLQDSVKNT--KDLNVKELKLK--EE 1188
E E I +LE N K EFQ+ +D + T + V L+ K +
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADS 1202
Query: 1189 ITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADL 1248
+ +L + +++ + Q E+E+ + ET+ L A S NL+ + E+ ++L
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL 1262
Query: 1249 KEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL 1308
K K + ++ I + + + ++ E +++E + +Q S+ + I++LK QL
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQL 1322
Query: 1309 NNQ-----KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE----------QEQTQVEQDQ 1353
+ + A+Q C L + + ++ + L+ Q +T+ E D
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1382
Query: 1354 VLEA-KLEEV-ERLATELEKWKE-------KCNDLETKNNQRSNKEHENNTDVL------ 1398
+ +LEE ++LA L++ +E KC LE + N+ + DV
Sbjct: 1383 IQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAAC 1442
Query: 1399 ----GKLTNLQDELQESEQKY---NADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDR 1451
K N L E +QKY A+ + +E L T+ + +N+ + + + R
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLR 1502
Query: 1452 ERFFKQQNEMEILTAQLTEKDSDLQKWREERDQL-VAALEIQLKALISSNVQKDNEIEQL 1510
Q E+ LT Q+ E + + + + Q+ EIQ AL + ++E ++
Sbjct: 1503 RENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQ-AALEEAEASLEHEEGKI 1561
Query: 1511 KRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVST 1570
RI E +++++++ ++I+ D + Q + T +E LD+ E+ +
Sbjct: 1562 LRIQLELNQVKSEV----DRKIAEKDEEIDQLKRNHT------RVVETMQSTLDA-EIRS 1610
Query: 1571 ENDQSTRFPKP------ELEIQFTPLQPNKMAVKH-------PGCTTPVTVKIPKARKRK 1617
ND + R K E+EIQ N++A + G + + A R
Sbjct: 1611 RND-ALRVKKKMEGDLNEMEIQLN--HANRLAAESLRNYRNTQGILKETQLHLDDA-LRG 1666
Query: 1618 SNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASII 1677
+++E L E + N + + ++ +K + + +S++ L +Q + +
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726
Query: 1678 GVNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAK 1737
+ TKKK L++ S LQS+ +++I+ +++ +A + + K
Sbjct: 1727 ---INTKKK----------LENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELK 1773
Query: 1738 RKLYTS 1743
++ TS
Sbjct: 1774 KEQDTS 1779
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 150 bits (379), Expect = 1e-35
Identities = 224/1095 (20%), Positives = 480/1095 (43%), Gaps = 142/1095 (12%)
Query: 681 KAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRI-KELINIIDQKEDT 739
+AE+AK + + ++EL + D + ELE ++ T + +E + +++Q E+
Sbjct: 375 RAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEE 434
Query: 740 INEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENEL 799
+ ++L+ +E +T + + + ++ K+ + + E+ + ++ L
Sbjct: 435 KRKVEDLQFRVEEESITKGDLETQTKLEHARI---------KELEQSLLFEKTKADK--L 483
Query: 800 QQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNE--GLRAFLLTIENE 857
Q++ + ++ S I E +K ++ + E+ ++R E+N+ G L++ E
Sbjct: 484 QRELEDTRVATVSEKSRIMELEK---DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
Query: 858 LKNEKEE----KAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSK 913
+ + +E+ + + ++I ++ E+ T KE++ + + + E KSK
Sbjct: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREE---THQKEIKALYTATEKLSKENESLKSK 597
Query: 914 ----NQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNL 969
N+E + I +++ETA S + ++K+ +K
Sbjct: 598 LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK--------------------- 636
Query: 970 RDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVK 1029
L + E TQ++ + DY +++ + Q+ + + +EA+ + +++K
Sbjct: 637 -GLGTETAEFAELKTQIEKMRLDY--QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
Query: 1030 ASSKKSHQIEELEQQIEKLQAE-VKGYKDENNRLKEKEHKNQD-DLLKEK--------ET 1079
+K + +E + +++K + + + +D N+L+E E K ++ ++L+ K +
Sbjct: 694 ---EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 750
Query: 1080 LIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSH 1139
QLK +EK + LD + EGK + +L Q + + +IK LE + E S
Sbjct: 751 FTSQLKAT-EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI---EKNAESSK 806
Query: 1140 SAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDM 1199
++ + +++ +E + L+ NL E + + K + L K + EE + ++Q+
Sbjct: 807 ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQET 866
Query: 1200 KHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI 1259
+ L KEE+ + EKL+E L AD++ K + + +E+L AK+++
Sbjct: 867 VNKLHQKEEQFNMLSSDLEKLRENL-----------ADMEAKFREKDEREEQLIKAKEKL 915
Query: 1260 KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQ 1319
+ E+ M ++ K+N+ EL +K+R +++L+ +L
Sbjct: 916 ENDIAEIMKMSGDNSSQLTKMND----------ELRLKERDVEELQLKLT---------- 955
Query: 1320 YERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKE----K 1375
+A ++ + +K IEDM + + EQ+Q E + E + +E+ER ++LEK E +
Sbjct: 956 --KANENASFLQKSIEDMTV---KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQ 1010
Query: 1376 CNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKE 1435
C +L+ + + +++ + ++ L NLQ L ++E K R EE L+ +
Sbjct: 1011 CQELKARYERATSETKTKHEEI---LQNLQKTLLDTEDKLKGAR----EENSGLLQEL-- 1061
Query: 1436 AENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKA 1495
+E++K A+ + ++ M+I+ Q+T++ ++ E+ Q A L+ +L
Sbjct: 1062 ------EELRKQADKAKAAQTAEDAMQIM-EQMTKEKTETLASLEDTKQTNAKLQNELDT 1114
Query: 1496 LISSNVQKDNEIEQLKRIIS-ETSKIETQIMDIKPKRISSADPDK----LQTEPLSTSFE 1550
L +N++ E+ + K +++ E K+E +I+ + ++A + LQ E + + E
Sbjct: 1115 LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1174
Query: 1551 ISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKI 1610
+ R++ E S E S N+Q K E + + K T+ + +
Sbjct: 1175 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234
Query: 1611 PKARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSL 1670
++ NE V +NA+ + +L + + VK E KV K
Sbjct: 1235 DAELEKLRNE-----VTVLRGENASAK-SLHSVVQTLESDKVKLELKVKNLELQLKENKR 1288
Query: 1671 RSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSK---AKKIIETMSSSKLSNVEASK 1727
+ +S + + E + DFL LQ K K +E MS + L+
Sbjct: 1289 QLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDL 1348
Query: 1728 ENV---SQPKRAKRK 1739
N Q K++K+K
Sbjct: 1349 NNYDSDDQEKQSKKK 1363
Score = 100 bits (248), Expect = 2e-20
Identities = 227/1099 (20%), Positives = 443/1099 (40%), Gaps = 184/1099 (16%)
Query: 182 SLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIK-EVTVHNDSDDTLYGSL 240
+LQE L K + E L + E+ E+A ++ + +I+ E+ + D D L
Sbjct: 352 ALQEALKEKQ-----QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLEL 406
Query: 241 TNSLNISEFEESIKDYEQANL-NMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKM 299
++ D E+ L N K V F + E I + +K + ++
Sbjct: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI 466
Query: 300 LRLSQDV-----KGYSFIKDLQWIQVSDSKEAYRLLKL----GIKHQSVAFTKLNNASSR 350
L Q + K ++L+ +V+ E R+++L ++ Q VA + S++
Sbjct: 467 KELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK 526
Query: 351 SHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQ---NEGERLRETGNINTSL 407
+ + ++ E+S + E++ D ++K E +E + T+
Sbjct: 527 PAGDVDMSLSLLQ--EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTAT 584
Query: 408 LTLGKCINVLK---------NSE-----KSKFQQHVPFRESKLTHYFQSFFNGKGKIC-- 451
L K LK NS+ KSK + + + + SF G G
Sbjct: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 644
Query: 452 ---MIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNS 508
+ I + L Y + L+ +++ + + + KL +K ++ SL++
Sbjct: 645 FAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN-SLEAIR 703
Query: 509 NSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLD--KTLEENKA 566
+ + + E++L L E E V+ELE + N +TK++D K EE
Sbjct: 704 SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE--- 760
Query: 567 FISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQ 626
KLLDL D +K +E K ++ K+R+++ + E ++
Sbjct: 761 --------KLLDL--DALRKASSEGKSEMK---KLRQQL-------------EAAEKQIK 794
Query: 627 EREILEENAE--RRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAEL 684
EI E+NAE + +I ++L G+ ELK ++ L
Sbjct: 795 HLEI-EKNAESSKASSITRELQGR-------------------------ELKLTNLQENL 828
Query: 685 AKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTIN--- 741
+ E+ + KE L+K E L ++ ++++ ++ + ++E +N + QKE+ N
Sbjct: 829 S----EVSQVKETLEK---ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 881
Query: 742 -EFQNLKSH---MENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNEN 797
+ + L+ + ME F+ D+ + + KL N+ E+ K S S+ ++N+
Sbjct: 882 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE-NDIAEIMKMSGDN-SSQLTKMND- 938
Query: 798 ELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENE 857
EL+ E ++ + ++ K +E IED+ V E ++ +
Sbjct: 939 ELRLKERDVEELQLKLT-------KANENASFLQKSIEDMTVKAEQSQ---------QEA 982
Query: 858 LKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQ 917
K +EEK EL +++LS EKK T + Q++++ Y+ A +E K+K++E
Sbjct: 983 AKKHEEEKKEL-------ERKLSDLEKKMETSHNQCQELKARYERATSE---TKTKHEEI 1032
Query: 918 EEKIMKLSNEIETATR-------SITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLR 970
+ + K + E + + + +++ K +T + QI
Sbjct: 1033 LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1092
Query: 971 DLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSF----HSSIEAIWEECKE 1026
+ E+ N +L N+ K+ ++E N+ + +E +E +
Sbjct: 1093 ETLASLEDTKQTNAKLQ---NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIET 1149
Query: 1027 IVKASSKKSHQIEELEQQIEKLQAEVKGYKDE---NNRLKEKEHKNQDDLL---KEKETL 1080
+ +A+++KS Q+ L+++ KL E+ +DE + +L+E+ + LL K +
Sbjct: 1150 LKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKF 1209
Query: 1081 IQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK---AKIKELETILETQKVEC 1137
I+ EE ++ + + E L +L VT + A K L ++++T
Sbjct: 1210 IKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT----- 1264
Query: 1138 SHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT-----KDLNVKELK---LKEEI 1189
LE D ++ E + LE LKE + L S NT +D +E + L I
Sbjct: 1265 -----LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1319
Query: 1190 TQLTNNLQDMKHLLQLKEE 1208
L QD+K +++ E
Sbjct: 1320 VDLQRKNQDLKMKVEMMSE 1338
Score = 67.8 bits (164), Expect = 9e-11
Identities = 181/849 (21%), Positives = 349/849 (41%), Gaps = 153/849 (18%)
Query: 204 LSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSLTNSL-----NISEFEESIKDYEQ 258
+SS QEK E+ +++ R+I + H + + + +L +S+ ES+K +
Sbjct: 541 ISSLQEKLEV-TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS-KL 598
Query: 259 ANLNMANSIKFSVWVSFFEI----YNEYIYDLFVPVSS------------KFQKRKM--- 299
+ N NS ++W S E + + + +L V S K Q KM
Sbjct: 599 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658
Query: 300 -------LRLSQDVKGYSFIKDLQWIQVS---------DSKEAYR--LLKLGIKHQSVAF 341
L+ QD + + K+++ ++ +S EA R L K +H
Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Query: 342 TKLNNASSRSHSIFTVKILQIEDSEMSRVI-------RVSELSLCDL-AGSERTMKTQNE 393
LN + +++LQ + +E ++VI + +E L DL A + + + ++E
Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
Query: 394 GERLRETGNINTSLLTLGKCINVLKNSEKSK---FQQHVPFRESKLTHYFQSFFNGKGKI 450
++LR+ + K + + KN+E SK + + RE KLT+ ++
Sbjct: 779 MKKLRQQLEAAEKQI---KHLEIEKNAESSKASSITRELQGRELKLTNLQEN-------- 827
Query: 451 CMIVNISQCYLAYDETLNVLKFS-------AIAQKVCVPDTLNS--SQEKLFGPVKSSQD 501
+ +SQ ++ L +LK A++ + + +T+N +E+ F + S +
Sbjct: 828 --LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 885
Query: 502 VSLDS---------NSNSKILNVKRATISWENSLEDLME------------------DED 534
++ + + + +A EN + ++M+ E
Sbjct: 886 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER 945
Query: 535 LVEELENAEETQNVETKLLDEDL-DKTLE----ENKAFISHEEKRKLLDL-IEDLKKKLI 588
VEEL+ N L + + D T++ + +A HEE++K L+ + DL+KK+
Sbjct: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM- 1004
Query: 589 NEKKEKLTLEFKIR-EEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVG 647
E E K R E T E + + ++TLL + L+ E + ++L
Sbjct: 1005 -ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE- 1062
Query: 648 KCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDS 707
+ R++A K A E +A +E Q+ E +T L TK+ K +NE D+
Sbjct: 1063 --ELRKQADKAKAAQTAE--DAMQIME----QMTKEKTETLASLEDTKQTNAKLQNELDT 1114
Query: 708 LIQELETSNKKIITQNQRIKELINIIDQK-EDTINEFQNLKSHMENTFKCNDKADTSSLI 766
L + +N K + + + KEL+ + +QK E+ E + LK K+ S +
Sbjct: 1115 L----KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ------AAAQKSQQLSAL 1164
Query: 767 INNKLICNETVEVPKD---SKSKICSERKRVNENELQ------------QDEPPAKKGSI 811
+ E + +D S K+ ER +N L+ +E + + SI
Sbjct: 1165 QEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1224
Query: 812 HVSSA-ITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNK 870
++SA +TE + E++R E+ +R + + L + + T+E++ + + L
Sbjct: 1225 SITSALLTEKDAELEKLR---NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1281
Query: 871 QIVHFQQELSLSEKKNLTLSKEVQQIQ-SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 929
Q+ +++LS S T + E ++ Q S D + + + KNQ+ + K+ +S
Sbjct: 1282 QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAAL 1341
Query: 930 TATRSITNN 938
NN
Sbjct: 1342 NGNGDDLNN 1350
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 150 bits (379), Expect = 1e-35
Identities = 249/1197 (20%), Positives = 508/1197 (42%), Gaps = 184/1197 (15%)
Query: 489 QEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNV 548
Q KL + S ++ ++ S + L++ R TI E + L + E V ++T
Sbjct: 1482 QRKLQAALISRKEALKENKSLQEELSLARGTI--ERLTKSLADVESQVSAQNKEKDTVLG 1539
Query: 549 ETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKL--INEKKEKLTLEFK-IREEV 605
LL E+ DK + E + E + L E LK L + E KEKL E + ++
Sbjct: 1540 RLALLQEERDKLITEMDRSLL--ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
Query: 606 TQEFTQYWAQREADFK---ETLLQEREILEENAERRLAIFK-------DLVGKCDTREEA 655
E T+ W ++ + + E LLQ E + AER + + +L GK + E
Sbjct: 1598 IAESTE-WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE-- 1654
Query: 656 AKDICATKVETEEATACLELKFNQIKAEL---AKTKGELIKTKEELKKR--------ENE 704
A K ETE+ E + ++K ++ AK+K + I EE R +
Sbjct: 1655 -----ANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1709
Query: 705 SDSLIQELETSNKKIITQNQRIK--------ELINIIDQKEDTINEFQNLKSHMENTFKC 756
+ ++ L +SN + + +R+K + +++ +K+ E Q+LK +E
Sbjct: 1710 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
Query: 757 NDKADTSSLIINNKLICNE-TVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSS 815
+ + N + E T +P +++ + + ++ + P+ K + +
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQ---DSLSMSTRPTCSESVPSAKSA---NP 1823
Query: 816 AITEDQKKSEEVRPNIAEIEDIRV----LQENNEGLRAFLLTIENE-------------- 857
A+++D +E+ + +I+ ++ L+E + + F T+ENE
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883
Query: 858 LKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQ 917
LK +EE ++N Q+ELS K T +E ++ +AEL+ N Q
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIG-NYCQ 1942
Query: 918 EEKIMKLSNEI-ETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGS 976
+ ++ NE+ E+ +++ VS+++ ++ + +T S+I L ++
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE-SEIRKEYLEKIQGAQKEP 2001
Query: 977 EEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSH 1036
+ +LL KQ+++ I+ + ++ +++A+ E V+ S+K
Sbjct: 2002 GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL-----EFVQTESQKDL 2056
Query: 1037 QI--EELEQQIE---KLQAEVKGYK---DENNRLKEKEHKNQDDLLKEKETLIQQLKEEL 1088
+I E L Q +E K QAE+ +K D+ + + L KE ++ + +K ++
Sbjct: 2057 EITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 1089 QEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDIL 1148
++K+ L+ +++ E + L E K ++E L +KV LE+ I
Sbjct: 2117 KQKDEDLERRLEQAEE--KHLKE--------KKNMQEKLDALRREKVH------LEETIG 2160
Query: 1149 EKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKH----LLQ 1204
E + + K ++ +++ QE+L +V L+++ ++ + + + +Q
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
Query: 1205 LKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDY----------ADLKEKLTD 1254
KEEE LK++L S + LK ++ R E D L++K+ D
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 1255 A-----KKQIKQV----------QKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQR 1299
K+ + Q+ Q E++ + E K L+ ++ +L +C ++ +
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG 2340
Query: 1300 TIQQLKEQLNNQK---------VEEAIQQYERACKDLNVKEKII--------EDMRMTLE 1342
I+Q + + N K ++ + + R +++N+KE+ I E +++ +
Sbjct: 2341 IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA 2400
Query: 1343 EQEQTQVEQDQVLEAKL--EEVERLATELEKWK--EKCNDL-ET-----KNNQRSNKEHE 1392
E Q ++ + LE L EE E + E E K +K N L ET K N + + +
Sbjct: 2401 ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
Query: 1393 NNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRE 1452
+ + L N +D + Q+ + EK LI +A N +E++
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGL----- 2515
Query: 1453 RFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKR 1512
++ M+ L ++ + D++L ++RE+ +Q++ + Q K L+ +Q++ E+E
Sbjct: 2516 -----RSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE---- 2566
Query: 1513 IISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVS 1569
++ +K+E ++ + + E L SF + + +D S ++S +VS
Sbjct: 2567 --NKYAKLEEKLKE-----------SEEANEDLRRSFNALQEEKQDLSKEIESLKVS 2610
Score = 143 bits (360), Expect = 2e-33
Identities = 294/1573 (18%), Positives = 633/1573 (40%), Gaps = 264/1573 (16%)
Query: 348 SSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSL 407
S+ ++ T K LQ + EM + ++ + ++ ++ + E +RLR ++ +
Sbjct: 1652 STEANKKETEKQLQEAEQEMEEM--KEKMRKFAKSKQQKILELEEENDRLR--AEVHPAG 1707
Query: 408 LTLGKCINVLKNSEKSKFQQ--HVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDE 465
T +C+ L +S S ++ V L+ FQS + K + V L +
Sbjct: 1708 DTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD----LKHQI 1763
Query: 466 TLNVLKFSAIAQKVCVPDTLNSSQE---KLFGPVKSSQDVSLDSNS--NSKILNVKRATI 520
NV K + + + N ++E + G + +S+ + + + + K A
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 521 SWENSLEDLMEDEDLVEELENAEE--TQNVETKLLDEDLDKTLEENKAFISHEEKRKLLD 578
+ E + +++++ +E E K +++ +TLE EK LL
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLEN--------EKNTLLS 1875
Query: 579 LI--EDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAE 636
I +D + K++ E+ K+ L + +++ +E + R KET +E++ LEE
Sbjct: 1876 QISTKDGELKMLQEEVTKMNL---LNQQIQEELS-----RVTKLKETAEEEKDDLEERLM 1927
Query: 637 RRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIK---AELAKTKGELIK 693
+LA +G +D+ +++ E LE + +K +EL + K +L+K
Sbjct: 1928 NQLAELNGSIGNY------CQDVTDAQIKNE----LLESEMKNLKKCVSELEEEKQQLVK 1977
Query: 694 TK----EELKKRENESDSLIQELETSNKKIITQNQRI-KELINIIDQKEDTINEFQNLKS 748
K E++K E Q+ E NK + Q + KE + Q + +Q S
Sbjct: 1978 EKTKVESEIRKEYLEKIQGAQK-EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKIS 2036
Query: 749 HMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKK 808
+E T K + T S + +E+ K++ ++ RK+ + EL +
Sbjct: 2037 ALERTVKALEFVQTES---------QKDLEITKENLAQAVEHRKKA-QAELASFKVLLDD 2086
Query: 809 GSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIEN----ELKNEKEE 864
+ + ++ K +E++ N ++ +++ +E L L E E KN +E+
Sbjct: 2087 TQSEAARVLADNLKLKKELQSNKESVKS--QMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
Query: 865 KAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHV---QKSKNQEQEEKI 921
L ++ VH ++ + + KEVQQ+Q N D + +L S Q+ +++
Sbjct: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
Query: 922 MKLSNEIETA-TRSITNNVSQIKLMHTKI----DELRTLDSVSQISNIDLLNLRDLSNGS 976
+ + + E + +I + +I+L D+LR + + I++ L
Sbjct: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
Query: 977 EEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS---IEAIWEECKEIVKASSK 1033
E QL D L + KE Q + +HSS + + E K + +
Sbjct: 2265 ESKAQTEVQLQQKVCDTLQGEN-KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTD 2323
Query: 1034 KSHQIEELEQQ---------------------IEKLQAEVKGYKDENNRLKEKEHKNQD- 1071
S+ +E+ ++Q E+L+ +++ ++ +RL E+ + +
Sbjct: 2324 LSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQK 2383
Query: 1072 --DLLKEKETLIQQLKEELQEK---------NVTLDVQIQHVV---EGKRALSELTQGVT 1117
LL KE IQ EL+++ N+ + +++V E K+A+ + Q +
Sbjct: 2384 IISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME 2443
Query: 1118 CYKAKIKE-------LETILETQKVECSHSAKLEQD-----------ILEKESIILKLER 1159
K KE L++ +++ + ++ D ILEK+ +I +
Sbjct: 2444 TLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAA 2503
Query: 1160 NLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDM--------KHLLQLKEEEEE 1211
+ +E ++ + DLN + KL E+ Q +L + K LL+++ ++ +
Sbjct: 2504 ENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK 2563
Query: 1212 TNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD 1271
+ KL+E+L S ++L+ +E+ DL +++ K I Q+ ++V+ +++
Sbjct: 2564 ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQE 2623
Query: 1272 EDKL--LRIKINELEKKKNQCSQELDMKQRTIQQLKEQL------NNQKVEEAIQQYERA 1323
E L ++ E++ ++ S Q+ I +L+E+L +KV E + ++
Sbjct: 2624 EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKE 2683
Query: 1324 CKDLNVKEKIIEDMRMTLEEQ----EQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1379
K L+ I+ + T EE+ + VE +Q L +E + L +++ + + L
Sbjct: 2684 LKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL 2743
Query: 1380 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLE---------EKMMLI 1430
+ ++++H N +EL E ++KY+A K+ + E+ L+
Sbjct: 2744 Q------NSRDHAN------------EELDELKRKYDASLKELAQLKEQGLLNRERDALL 2785
Query: 1431 TQAKEAENIRNKEMKKYAED-RERFFKQQNEMEILTAQLTEKDSDLQKW-------REER 1482
++ + N + + E ++ + ++ L++QL + + +Q + + ER
Sbjct: 2786 SETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2845
Query: 1483 DQL----------------------VAALEIQL--KALISSNVQKDNEIEQLKRIISETS 1518
D L + E+Q KA+ S +D +++LK + +
Sbjct: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
Query: 1519 KIETQIMDIKPKRISSAD-----------PDKLQTEPLSTSFEISRNKIEDGSVVLDS-- 1565
+I +I ++ P + + ++L+ E LS E+ + ++E S +
Sbjct: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERR 2965
Query: 1566 ------CEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSN 1619
+S ++ Q + E++ + Q + V++ +P T P
Sbjct: 2966 MKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASP-------- 3017
Query: 1620 EMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKK--EQKVAIRPSSKKTYSLRSQASII 1677
+ +N T L + N S+K+ ++++ I+ + L + + +
Sbjct: 3018 ---------DGSQNLVYETEL---LRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTL 3065
Query: 1678 GVNL--ATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKR 1735
+ L ++ Q +GD L H + +K ++ + + L N++ + +
Sbjct: 3066 SIQLCDTSQSLRENQQHYGDLLNHCAVL-----EKQVQELQAGPL-NIDVAPGAPQEKNG 3119
Query: 1736 AKRKLYTSEISSP 1748
RK E+ P
Sbjct: 3120 VHRKSDPEELREP 3132
Score = 134 bits (337), Expect = 8e-31
Identities = 283/1394 (20%), Positives = 589/1394 (42%), Gaps = 232/1394 (16%)
Query: 476 AQKVCVPDTLNSSQEKLFGPVKSSQDV-SLDSNSNSKILNVKRA-TISWE-----NSLED 528
A+KV + ++S+ +L K S++V L N + L ++ T+S E SL+
Sbjct: 1316 AEKVELELKVSSTTSEL---TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQ 1372
Query: 529 LMEDEDLVEELENAEETQNVETKLLDEDLDKTL---EENKAFISHEEKRKLLDLIEDLKK 585
+E L ++ E + ++ KL ++L K + EE+ +++S + K L + ++
Sbjct: 1373 KLESSQL--QIAGLEHLRELQPKL--DELQKLISKKEEDVSYLSGQLSEKEAALTK-IQT 1427
Query: 586 KLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDL 645
++I ++ L ++ E +E + Q + + E + EI EE+ ++ I + L
Sbjct: 1428 EIIEQEDLIKALHTQL-EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ-QIQRKL 1485
Query: 646 VGKCDTREEAAKDICATKVETEEATACLEL---KFNQIKAELAKTKGELIKTKEELKKRE 702
+R+EA K+ + + E A +E ++++++ E L +
Sbjct: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
Query: 703 NESDSLIQELETS---NKKIITQNQRIK-ELINIIDQKEDTINEFQNLKSHMENTFKCND 758
E D LI E++ S N+ + + + +K L + + KE + E ++LKS +
Sbjct: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS--------SK 1597
Query: 759 KADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNEN-ELQQDEPPAKKGSIHVSSAI 817
A+++ +K + E E+ S + +E +R+ E + E G + + A
Sbjct: 1598 IAESTEWQEKHKELQKE-YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1656
Query: 818 T-EDQKKSEEVRPNIAEIED------------IRVLQENNEGLRAFLLTIENELKNEKEE 864
E +K+ +E + E+++ I L+E N+ LRA + + K E
Sbjct: 1657 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET 1716
Query: 865 KAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAEL---------HVQKSKNQ 915
N + ++EL + + TLSK+ Q + S D E+ +V K N
Sbjct: 1717 LLSSNASM---KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANL 1773
Query: 916 EQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNG 975
E EK +N E T+SI + + + +SV + + +D S+
Sbjct: 1774 EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS-ESVPSAKSANPAVSKDFSSH 1832
Query: 976 SEEDNLPNTQLDLLGNDYLVSKQVKEYRI----QEPNRENSFHSSIEAIWEECKEIVKAS 1031
E +N Q+D Q+KE RI +E + F ++E E ++
Sbjct: 1833 DEINNYLQ-QID----------QLKE-RIAGLEEEKQKNKEFSQTLE---NEKNTLLSQI 1877
Query: 1032 SKKSHQIEELEQQIEKLQAEVKGYKDENNR---LKEKEHKNQDDLLKEKETLIQQLKE-- 1086
S K +++ L++++ K+ + ++E +R LKE + +DDL +E L+ QL E
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL---EERLMNQLAELN 1934
Query: 1087 -----------ELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKE------LETI 1129
+ Q KN L+ +++++ + L E Q + K K++ LE I
Sbjct: 1935 GSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKI 1994
Query: 1130 LETQKV--ECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKE 1187
QK SH+ +L++ + EK+ + +L+++ +QE + + K L + + ++
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
Query: 1188 EITQLTNNL-QDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYA 1246
++ NL Q ++H +K + EL++ + +++ R D
Sbjct: 2055 DLEITKENLAQAVEH---------------RKKAQAELASFKVLLDDTQSEAARVLADNL 2099
Query: 1247 DLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE 1306
LK++L K+ +K K+ +DED LE++ Q ++ +++ +Q+ +
Sbjct: 2100 KLKKELQSNKESVKSQMKQ----KDED---------LERRLEQAEEKHLKEKKNMQEKLD 2146
Query: 1307 QLNNQKV--EEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVER 1364
L +KV EE I + + LN K+K ++ ++ L+ + + + ++ +R
Sbjct: 2147 ALRREKVHLEETIGEIQVT---LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2203
Query: 1365 LATELEKWKEKCND-LETKNNQRSNKEHENNT--DVLGKLTNLQDELQESEQKYNADRKK 1421
+ E +KW+ K +D +++K + KE + D L +++ +EL+ + + D++
Sbjct: 2204 VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQI 2263
Query: 1422 W---------LEEKMMLITQAKEAENIRNKEMKK--YAEDRERFFKQQNEMEILTAQLTE 1470
W L++K+ Q + E + E + Y + K ++E++ L QLT+
Sbjct: 2264 WESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTD 2323
Query: 1471 KDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPK 1530
+ L+K +E++ L + Q + +S + L+ TS++ +I ++K +
Sbjct: 2324 LSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI-NMKEQ 2382
Query: 1531 RISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPL 1590
+I S K + ++ + E+ ++D+ + ELE
Sbjct: 2383 KIISLLSGK------------------EEAIQVAIAELRQQHDKEIK----ELE------ 2414
Query: 1591 QPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNS 1650
S E EE++V E K A +TN +
Sbjct: 2415 ------------------------NLLSQEEEENIVLEEENKKAVDKTNQLM----ETLK 2446
Query: 1651 SVKKE---QKVAIRPSSKKTYSLRSQAS-IIGVNLATKKKEGTLQKFGDFLQHSPSILQS 1706
++KKE QK + K SL++ I+G +++ ++ D L + +
Sbjct: 2447 TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENN 2506
Query: 1707 KAKKIIETMSS------SKLSNVEAS----KENVSQPKRAK----RKLYTSEISSPIDIS 1752
K K+ I + S S+ + ++A +E+++Q K ++L ++ ++
Sbjct: 2507 KLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE 2566
Query: 1753 GQVILMDQKMKESD 1766
+ +++K+KES+
Sbjct: 2567 NKYAKLEEKLKESE 2580
Score = 132 bits (331), Expect = 4e-30
Identities = 321/1563 (20%), Positives = 632/1563 (40%), Gaps = 234/1563 (14%)
Query: 144 QSRLIFTYGLTNSGKTY--TFQGTEENIGILPRTLNVLFDSLQERLYTK---MNLKPHRS 198
QSR L ++G T Q ++++ +P D L ERL ++ + L H++
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDEL-ERLKSQILELELNFHKA 703
Query: 199 REYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSD--------DTLYGSLTNSLNISEFE 250
+E + +++ +EI++ + L+ + K+ +N S D L + ++E
Sbjct: 704 QEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELR 763
Query: 251 ESIKDYEQ--ANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKG 308
+K E A + + + + E I+ L + SK K ++L+ D
Sbjct: 764 AQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELD--- 820
Query: 309 YSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMS 368
D+Q +Q S+ R L+ ++L N S +E +E
Sbjct: 821 -----DVQ-LQFSEQSTLIRSLQ----------SQLQNKESEV----------LEGAERV 854
Query: 369 RVI--RVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQ 426
R I +V ELS Q ++ E ++ LL + + L+ + + K Q
Sbjct: 855 RHISSKVEELS-------------QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 427 QHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDT-- 484
Q S Q + K + V I E LN+L + A+K V +
Sbjct: 902 QVTEISFSMTEKMVQL---NEEKFSLGVEIK----TLKEQLNLLSRAEEAKKEQVEEDNE 954
Query: 485 LNSSQEKLFGPVKSSQDVS----------LDSNSNSKILNVKRATISWENSLEDLMEDED 534
++S ++ + + + +S L + + ++ A I N E L
Sbjct: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI---NRKELLQRVSR 1011
Query: 535 LVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEK--RKLLDLIEDLKKKLINEKK 592
L EEL N ++ E L + + + +EE+K + EK IE K+ I+EK+
Sbjct: 1012 LEEELANLKDESKKEIPLSETERGE-VEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKE 1070
Query: 593 EKLT-----LEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVG 647
+L LE K+ E ++F Q ++ Q + E +E + I K +
Sbjct: 1071 VELQHIRKDLEEKLAAE--EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITS 1128
Query: 648 KCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDS 707
D + D A ET + K EL + L K KE+L+K+
Sbjct: 1129 NTDASDG---DSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKK------ 1179
Query: 708 LIQELETSNKKIITQNQ-RIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLI 766
+QE TS K I+ + Q + + L + Q++D ++ L+ + K N+
Sbjct: 1180 -LQEALTSRKAILKKAQEKERHLREELKQQKD---DYNRLQEQFDEQSKENENIGDQLRQ 1235
Query: 767 INNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEE 826
+ ++ + ++P + + CS + +EP K H + + E +
Sbjct: 1236 LQIQVRESIDGKLPSTDQQESCSSTPGL-------EEPLFKATEQHHTQPVLESNLCPDW 1288
Query: 827 VRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKN 886
+ ED LQ + I+ +LK + EK EL ++ EL+ KK
Sbjct: 1289 P----SHSEDASALQGGTS-----VAQIKAQLKEIEAEKVELELKVSSTTSELT---KK- 1335
Query: 887 LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 946
S+EV Q+Q + E+ K+ + E E L ++E++ I + ++ +
Sbjct: 1336 ---SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG-LEHLRELQ 1391
Query: 947 TKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQE 1006
K+DEL+ L S + ++ L+ LS +E L Q +++ + L+ + +Q
Sbjct: 1392 PKLDELQKLISKKE-EDVSYLS-GQLSE--KEAALTKIQTEIIEQEDLIKALHTQLEMQA 1447
Query: 1007 PNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKE 1066
+ I+ + E E+ + + + +Q KLQA + K+ KE
Sbjct: 1448 KEHDER----IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEAL-----KE 1498
Query: 1067 HKNQDDLLKEKETLIQQLKEELQ--EKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIK 1124
+K+ + L I++L + L E V+ + + V G+ AL + + I
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL-----IT 1553
Query: 1125 ELE-TILETQKVECS-HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKE 1182
E++ ++LE Q + S S KL + L ++ E+ +KE + + + + K
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDK-----EKLVKEIESLKSSKIAESTEWQEKH 1608
Query: 1183 LKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKE 1242
+L++E L + +++ + + + E RQE ++L +L ++ A + + LQ E
Sbjct: 1609 KELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAE 1668
Query: 1243 EDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQ 1302
++ ++KEK+ +K K Q+++ + +E+ LR +++ +C + L +
Sbjct: 1669 QEMEEMKEKM---RKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS-- 1723
Query: 1303 QLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEV 1362
+KE+L K+E YE TL ++ Q+ + + L EEV
Sbjct: 1724 -MKEELERVKME-----YE------------------TLSKKFQSLMSEKDSLS---EEV 1756
Query: 1363 ERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLT-NLQDELQESEQKYNADRKK 1421
+ L ++E ++ + N + ++H+N T+V + T ++ E +E + + R
Sbjct: 1757 QDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPT 1810
Query: 1422 WLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREE 1481
E + AK A +K+ + D + QQ + QL E+ + L++ +++
Sbjct: 1811 CSES----VPSAKSANPAVSKDFSSH--DEINNYLQQID------QLKERIAGLEEEKQK 1858
Query: 1482 RDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMD-----IKPKRISSAD 1536
+ LE + L+S KD E++ L+ +++ + + QI + K K + +
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 1537 PDKLQTEPLS----------------TSFEISRNKIEDGSVVLDSC--EVSTENDQSTR- 1577
D L+ ++ T +I +E L C E+ E Q +
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978
Query: 1578 FPKPELEIQFTPLQPNKMAVKHPGCTTPV--TVKIPKARKRKSNEMEEDLVKCENKKNAT 1635
K E EI+ L+ + A K PG + ++ K ++++ ++++D ++ + K +A
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISAL 2038
Query: 1636 PRT 1638
RT
Sbjct: 2039 ERT 2041
Score = 123 bits (309), Expect = 1e-27
Identities = 228/1153 (19%), Positives = 492/1153 (42%), Gaps = 159/1153 (13%)
Query: 529 LMEDEDLVEELE------NAEETQNVETKLLDEDLDKT-LEENKAFISHEEKRKLLDLIE 581
L E E+L+ L+ AE+ T++ + + K L+E + FIS + + E
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212
Query: 582 DLKKKLINEKKEKLTLEFKIRE-EVTQEFTQYWAQREADFKETLLQEREILEENAERRLA 640
++++ EK + + ++ E E+ Q TQ + E K +LQ + LEE+ E
Sbjct: 213 QAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK--LEEHEE---- 266
Query: 641 IFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKK 700
LVG+ + +++ A E+ L + Q++AE T ++T+ E
Sbjct: 267 ---SLVGRAQVVDLLQQELTAA----EQRNQILSQQLQQMEAE-HNTLRNTVETERE--- 315
Query: 701 RENESDSLIQ--ELETSNKKIITQN--QRIKELINIIDQKEDTINEFQNLKSHMENTFKC 756
ES L++ ELE + +K+ N + + L+ +Q E ++ S +E K
Sbjct: 316 ---ESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA 372
Query: 757 NDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSA 816
+ TS ++ +++ C K N LQ A + + +
Sbjct: 373 EMEEKTSHIL---------SLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQL 423
Query: 817 ITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEK--AELNKQIVH 874
+ Q+KS+E+ + + LQ++ + + NE E+ A L K++V
Sbjct: 424 EDQLQQKSKEISQFLNRLP----LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVE 479
Query: 875 FQQE---LSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNE---- 927
+ E L LS + L E +++ S + A+ ++ + E I+ ++N+
Sbjct: 480 LENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS 539
Query: 928 IETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLD 987
E + + + N K + L ++ +I+ + L + ++ + L ++
Sbjct: 540 AEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMK 599
Query: 988 LLGNDYLVSKQVKEYRIQE-------PNRENSFHSSIEAIWEECKEIVKASSKKSHQIEE 1040
+ + + ++K + PN E SS+ A+ +E +AS++ + E
Sbjct: 600 QMEGEGIAPIKMKVFLEDTGQDFPLMPNEE----SSLPAVEKE-----QASTEHQSRTSE 650
Query: 1041 LEQQIEKLQAEVKGYKDENNR----LKEKEHKNQDDLLKEKETLIQ-----QLKEELQEK 1091
E + E+K K + ++ + + +QD+L + K +++ +E+ EK
Sbjct: 651 -EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEK 709
Query: 1092 NVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE---TILETQKVECSHSAKLEQDIL 1148
N+ E + +S L Q + +K T L ++ + K +
Sbjct: 710 NLD---------EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVT 760
Query: 1149 EKESIILKLERNLKEFQEHLQ-DSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKE 1207
E + + +LE NL E + + D T N+ LT + + + K+
Sbjct: 761 ELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL-----------LTEQIHSLSIEAKSKD 809
Query: 1208 EEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVS 1267
+ E + E + ++ + S S ++L++ LQ KE + + E++ +++++ + +S
Sbjct: 810 VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869
Query: 1268 VMRDEDKLLRIKINELEKKKN--QCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACK 1325
+ E ++ ++ LEKK++ Q ++ K + + ++ + + V+ +++ +
Sbjct: 870 --QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVE 927
Query: 1326 DLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE-VERLATELEKWKEKCN---DLET 1381
+KE++ ++ EE ++ QVE+D + + L++ + ++ + KE+ DL
Sbjct: 928 IKTLKEQL--NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK 985
Query: 1382 KNNQRSNKEHE----NNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAE 1437
K N++ ++ + N ++L +++ L++EL + + +K + +++ + E
Sbjct: 986 KENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE---------SKKEIPLSETERGE 1036
Query: 1438 NIRNKEMKKYAEDRERFFKQQNEMEILTAQ-LTEKDSDLQKWREERDQLVAALEIQLKAL 1496
+KE K+Y+E + + E+EI Q ++EK+ +LQ R++ ++ +AA E Q +AL
Sbjct: 1037 VEEDKENKEYSE--KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA-EEQFQAL 1093
Query: 1497 ISSNVQ----KDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEIS 1552
+ Q K N+I+ L+ ISE I I + ++D D +
Sbjct: 1094 VKQMNQTLQDKTNQIDLLQAEISENQAI---IQKLITSNTDASDGDSVAL---------- 1140
Query: 1553 RNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNK--MAVKHPGCTTPVTVKI 1610
+++ V+ C S+E+ KPELE + L+ K + K T +
Sbjct: 1141 ---VKETVVISPPCTGSSEH------WKPELEEKILALEKEKEQLQKKLQEALTSRKAIL 1191
Query: 1611 PKARKRKSNEMEE 1623
KA++++ + EE
Sbjct: 1192 KKAQEKERHLREE 1204
Score = 117 bits (294), Expect = 8e-26
Identities = 268/1352 (19%), Positives = 563/1352 (41%), Gaps = 176/1352 (13%)
Query: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISH--EEKRKLLDLIEDLK 584
+ L + E L N ET+ E+K+L E ++ + E K + EE LL+ E
Sbjct: 294 QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
Query: 585 KKLIN--------EKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAE 636
+ E+K K +E K ++ + T Q D + Q ++L++ E
Sbjct: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD--QNSKLLQDKNE 411
Query: 637 RRLAIFKDLVGKCDTREEAAKDIC-------------------------ATKVETEEATA 671
+ + + + D ++ +K+I T+ TEE A
Sbjct: 412 QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIA 471
Query: 672 CLELKFNQIKAELAKTKGELIKTK---EELKKRENESDSLIQELETSNKKIITQNQRIKE 728
L+ + EL KG L+ + EELK + S I LE N+ + R
Sbjct: 472 SLQKRV----VELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNR--TGEADREVS 525
Query: 729 LINIID-QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI 787
I+I+D + + + ++ + +ENTF K + S L++ K E + + K
Sbjct: 526 EISIVDIANKRSSSAEESGQDVLENTFSQKHK-ELSVLLLEMKEAQEEIAFLKLQLQGKR 584
Query: 788 CSE--RKRVNENELQQDE----------------------PPAKKGS---IHVSSAITED 820
E + +++ E++Q E P ++ S + A TE
Sbjct: 585 AEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644
Query: 821 QKK-SEEVRPNIAEIEDIRVLQENNEGLRA---FLLTIENELKNEKEEKAELNKQIVHFQ 876
Q + SEE+ N A +E Q+ ++ L A ++EL+ K + EL ++F
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE---LNFH 701
Query: 877 QELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN-------QEQEEKIMKLSNEIE 929
+ + EK +KE+ SN + I E N E+ ++++ E+
Sbjct: 702 KAQEIYEKNLDEKAKEI----SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757
Query: 930 TATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLL 989
T + V Q+++ + + R LD SQ ++ +LL + + S E + ++++L
Sbjct: 758 MVT-ELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT-EQIHSLSIEAKSKDVKIEVL 815
Query: 990 GNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSH---QIEELEQQIE 1046
N ++ + ++Q + S + + E+++ + + H ++EEL Q +
Sbjct: 816 QN------ELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869
Query: 1047 KLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV-------TLDVQI 1099
+ + E+ D+ K+++ + ++EK+ + ++ + EK V +L V+I
Sbjct: 870 QKELEIT-KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 1100 QHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLER 1159
+ + E LS + + E+ + L+ E S + ++ ++ L+ E +LK E
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 1160 NLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEK 1219
++ + LQ ++ N K+L + +L+EE+ L + + L + + E E +++ E
Sbjct: 989 --EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046
Query: 1220 LKEELSASSARTQ-NLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRI 1278
++ +++ + LK + KE + +++ L + +Q Q ++++ ++ L+
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ---ALVKQMNQTLQD 1103
Query: 1279 KINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKV----EEAIQQYERACKDLNVKEKII 1334
K N+++ + + S+ + Q+ I + + V E + + K ++
Sbjct: 1104 KTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELE 1163
Query: 1335 EDMRMTLEEQEQTQVEQDQVLEA------KLEEVER-LATELEKWKEKCNDLETKNNQRS 1387
E + +E+EQ Q + + L + K +E ER L EL++ K+ N L+ + +++S
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS 1223
Query: 1388 NKEHENNTDVLGKL-----TNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNK 1442
KE+EN D L +L ++ +L ++Q+ + LEE + T+ + +
Sbjct: 1224 -KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES 1282
Query: 1443 EM----KKYAEDRE---------RFFKQQNEMEI----LTAQLTEKDSDLQKWREERDQL 1485
+ ++ED + Q E+E L +++ S+L K EE QL
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342
Query: 1486 VAALE---IQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQT 1542
+ +++++L + + + + E L++ + + + QI ++ R D+LQ
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLESS---QLQIAGLEHLRELQPKLDELQ- 1398
Query: 1543 EPLSTSFEISRNKIEDGSVV---LDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKH 1599
++ K ED S + L E + Q+ + +L I+ Q A +H
Sbjct: 1399 -------KLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL-IKALHTQLEMQAKEH 1450
Query: 1600 PGCTTPVTVKIPKARKRKSNEMEEDLVKCE-NKKNATPRTNLKFPISDDRNSSVKKEQKV 1658
+ V++ + +++ EE K + +K + K + + N S+++E +
Sbjct: 1451 DERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE--NKSLQEELSL 1508
Query: 1659 AIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMS-S 1717
A + T SL S V+ K+K+ L + + ++ + ++E S S
Sbjct: 1509 ARGTIERLTKSLADVES--QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLS 1566
Query: 1718 SKLSNVEASKENVSQPKRAKRKLYTSEISSPI 1749
S +++ + E +++ K K S SS I
Sbjct: 1567 SSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
Score = 113 bits (282), Expect = 2e-24
Identities = 308/1517 (20%), Positives = 607/1517 (40%), Gaps = 290/1517 (19%)
Query: 422 KSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCV 481
+++ QQ + + KL + +S +V++ Q L E N + + Q
Sbjct: 247 ETEMQQKLRVLQRKLEEHEESLVGR----AQVVDLLQQELTAAEQRNQILSQQLQQMEAE 302
Query: 482 PDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELEN 541
+TL ++ E + + L+ L V +S+ N E++ L+E+ E
Sbjct: 303 HNTLRNTVET----EREESKILLEKME----LEVAERKLSFHNLQEEM---HHLLEQFEQ 351
Query: 542 AEETQ-NVETKL--LDEDLDKTLEENKAFI-----SHEEKRKLLDLIEDLKKKLINEKKE 593
A + Q +E++ L++ +EE + I + +E + D ++D KL+ +K E
Sbjct: 352 AGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNE 411
Query: 594 KLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLV--GKCDT 651
+ + +++ + Q + LQ+ E + + F D+ G
Sbjct: 412 QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS------FPDVYNEGTQAV 465
Query: 652 REEAAKDICATKVETEEATACL---ELKFNQIKAELAKTKGELIKTKEELKKRENESDSL 708
EE + VE E L ++ ++KAE K ++ T E + R E+D
Sbjct: 466 TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI--TLLEAQNRTGEADRE 523
Query: 709 IQEL-------------ETSNKKII--TQNQRIKELINIIDQKEDTINEFQNLKSHMENT 753
+ E+ E S + ++ T +Q+ KEL ++ + ++ E LK ++
Sbjct: 524 VSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQG- 582
Query: 754 FKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEP--PAKKGS- 810
K ++AD L + E+ + I + +V + QD P P ++ S
Sbjct: 583 -KRAEEADHEVL---------DQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL 632
Query: 811 --IHVSSAITEDQKK-SEEVRPNIAEIE----------------DI-RVLQENNEGLRAF 850
+ A TE Q + SEE+ N A +E DI + Q+ E L++
Sbjct: 633 PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692
Query: 851 LLTIE-----------NELKNEKEEKAELNKQIVHFQQEL--------SLSEKKNLTLSK 891
+L +E L + +E + LN+ I F++ +LSE+++ LS+
Sbjct: 693 ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752
Query: 892 ------------EVQQIQSNY------------------DIAIAELHVQKSKNQEQEEKI 921
+V+Q++ N ++ ++H + + ++ KI
Sbjct: 753 VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKI 812
Query: 922 MKLSNEIETATRSITNNVSQIKLMHTKID--ELRTLDSVSQISNIDLLNLRDLSNGSEED 979
L NE++ + + I+ + +++ E L+ ++ +I + +LS +
Sbjct: 813 EVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS-KVEELSQALSQK 871
Query: 980 NLPNTQLDLL----------------GNDYLVSK---QVKEYRIQEPNRENSFHSSIEAI 1020
L T++D L D V++ + E +Q + S I+ +
Sbjct: 872 ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTL 931
Query: 1021 WEECKEIVKASSKKSHQIEE-------LEQQI-----------EKLQAEVKGYKDENNRL 1062
E+ + +A K Q+EE L+Q E+LQ E K EN
Sbjct: 932 KEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN--- 988
Query: 1063 KEKEHKNQDDLLKEKETL--IQQLKEEL------QEKNVTLDVQIQHVVEGKRALSELTQ 1114
++++ K Q L+ KE L + +L+EEL +K + L + VE + E ++
Sbjct: 989 EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1048
Query: 1115 GVTCYKAKIKELETILET----QKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQD 1170
C +K +E+E L+ ++VE H + +D+ EK + + + +K+ + LQD
Sbjct: 1049 --KCVTSKCQEIEIYLKQTISEKEVELQH---IRKDLEEKLAAEEQFQALVKQMNQTLQD 1103
Query: 1171 SVKNTKDLNVKELKLKEEITQ--LTNNLQ----DMKHLLQLKEEEEETNRQETEKLKEEL 1224
N DL E+ + I Q +T+N D L++ +E K EL
Sbjct: 1104 KT-NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162
Query: 1225 SASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELE 1284
+ K LQ+K L+E LT K +K+ Q++ +R+E K + N L+
Sbjct: 1163 EEKILALEKEKEQLQKK------LQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ 1216
Query: 1285 KKKNQCSQELDMKQRTIQQLKEQLNNQ---KVEEAIQQYERACKDLNVKEKIIEDMRMTL 1341
++ ++ S+E + ++QL+ Q+ K+ QQ E ++E + + T
Sbjct: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ-ESCSSTPGLEEPL---FKATE 1272
Query: 1342 EEQEQTQVEQD---------------------QVLEAKLEEVERLATELE-KWKEKCNDL 1379
+ Q +E + ++A+L+E+E ELE K ++L
Sbjct: 1273 QHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL 1332
Query: 1380 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI 1439
K+ + + + N L ++ +L+ E+E + ++K LE + I + +
Sbjct: 1333 TKKSEEVFQLQEQINKQGL-EIESLKTVSHEAEVHAESLQQK-LESSQLQIAGLEHLREL 1390
Query: 1440 RNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWRE---ERDQLVAALEIQLKAL 1496
+ K E ++ K++ ++ L+ QL+EK++ L K + E++ L+ AL QL+
Sbjct: 1391 Q----PKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQ 1446
Query: 1497 ISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKI 1556
+ D I+QL ++E M KP+ I K Q + + ISR +
Sbjct: 1447 AK---EHDERIKQL--------QVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495
Query: 1557 EDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKR 1616
+ L E+S R K +++ N K + + R +
Sbjct: 1496 LKENKSLQE-ELSLARGTIERLTKSLADVESQVSAQN----KEKDTVLGRLALLQEERDK 1550
Query: 1617 KSNEMEEDLVKCENKKNATPRTNLKFP---ISDDRNSSVKKEQKVAIRPSSKKTYSLRSQ 1673
EM+ L+ EN+ ++ +LK +++D+ VK+ + + +
Sbjct: 1551 LITEMDRSLL--ENQSLSSSCESLKLALEGLTEDKEKLVKEIESL--------------K 1594
Query: 1674 ASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSS---------SKLSNVE 1724
+S I + ++K LQK + L S + ++A++I + + KL + E
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE 1654
Query: 1725 AS-KENVSQPKRAKRKL 1740
A+ KE Q + A++++
Sbjct: 1655 ANKKETEKQLQEAEQEM 1671
Score = 110 bits (274), Expect = 2e-23
Identities = 201/993 (20%), Positives = 412/993 (41%), Gaps = 175/993 (17%)
Query: 475 IAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSN-----SKILNVKRATISWENSLEDL 529
+ QKVC DTL ++L ++ ++ + S + S++ ++K NSLE
Sbjct: 2274 LQQKVC--DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331
Query: 530 MEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFIS--HEE----KRKLLDL---- 579
E + +E + +E +K E L+ L+ ++ S HEE ++K++ L
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGK 2391
Query: 580 ------------------IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFK 621
I++L+ L E++E + LE + ++ V + T + K
Sbjct: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK--TNQLMETLKTIK 2449
Query: 622 ETLLQEREILEENAERRLAIFKD---LVGKCDTREEAAKDICATKVETEEATACLELKFN 678
+ +Q++ L+ + ++ D +VG EE I K + + A + N
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAA---ENN 2506
Query: 679 QIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINI-IDQKE 737
++K E+ + + E K + E LIQ E N+ I ++ + K+L+ + + Q +
Sbjct: 2507 KLKEEIRGLRSHMDDLNSENAKLDAE---LIQYREDLNQVITIKDSQQKQLLEVQLQQNK 2563
Query: 738 DTINEFQNLKSHMENTFKCNDKADTS-SLIINNKLICNETVEVPKDSKSKICSERKRVNE 796
+ N++ L+ ++ + + N+ S + + K ++ +E K S S++ + + E
Sbjct: 2564 ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQE 2623
Query: 797 NE---LQQDEPPAKKGSIHVSSAITEDQKK------------SEEVRPNIAEIEDIRVLQ 841
L + K+ +H SA+ +K +E + EIED L+
Sbjct: 2624 EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED--KLK 2681
Query: 842 ENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQ------ 895
+ + L + NE + +E AEL + +V +Q+L + K+N L+ ++Q
Sbjct: 2682 KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741
Query: 896 -IQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRT 954
+Q++ D A EL K K +++ +L + + N L T T
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQLKEQ------GLLNRERDALLSETAFSMNST 2795
Query: 955 LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFH 1014
++ +S+++ LN + LS + +L + D SK + S
Sbjct: 2796 EEN--SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMA-----------SLQ 2842
Query: 1015 SSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLL 1074
+ + +W E ++ K+ K Q AEV+ K + L+ ++D LL
Sbjct: 2843 NERDHLWNELEKFRKSEEGKQRSAA----QPSTSPAEVQSLKKAMSSLQN----DRDRLL 2894
Query: 1075 KEKETLIQQ---LKEELQEKNVTLDVQIQHVVEGKRALS----ELTQGVTCYKAKIKELE 1127
KE + L QQ + +E+ E + L Q+Q + +A EL Q ++ ++ +L
Sbjct: 2895 KELKNLQQQYLQINQEITELH-PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR 2953
Query: 1128 TILETQKVECSHSAKLEQDIL----EKESIILKLERNLKEFQEHLQDSVKNTKDLNVK-- 1181
+ ++ H ++++ L +K+ + L+ ++E L+ S T+ L V+
Sbjct: 2954 MEKSSWEI---HERRMKEQYLMAISDKDQQLSHLQNLIRE----LRSSSSQTQPLKVQYQ 3006
Query: 1182 ---------------ELKLKEEI--TQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEEL 1224
L + E+ TQL ++L+++ H +L+ ++ +N + L EE
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEI-HQKELRIQQLNSNFSQ---LLEEK 3062
Query: 1225 SASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQK-----EVSVMRDEDKLLRIK 1279
+ S + + L+ ++ Y DL +KQ++++Q +V+ ++K
Sbjct: 3063 NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEK----- 3117
Query: 1280 INELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRM 1339
N + +K + +EL Q++ + ++QL N + E + ++R
Sbjct: 3118 -NGVHRKSD--PEELREPQQSFSEAQQQLCNTRQE-------------------VNELRK 3155
Query: 1340 TLEEQEQTQVEQDQVLEAKLEEVERLATELEKW 1372
LEE+ +V + L E++ RL E +W
Sbjct: 3156 LLEEERDQRVAAENALSVAEEQIRRL--EHSEW 3186
Score = 85.9 bits (211), Expect = 3e-16
Identities = 150/701 (21%), Positives = 284/701 (40%), Gaps = 97/701 (13%)
Query: 1064 EKEHKNQDDL---LKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCY- 1119
E + Q+D+ L E L+ +LK+ +++K+V L + + + E ++A + + +
Sbjct: 41 EFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA 100
Query: 1120 KAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLN 1179
KAK+ L +E K + E E+ S K+ K
Sbjct: 101 KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS--------------------KHDKSST 140
Query: 1180 VKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQN----LK 1235
+E+++++ +KH LQ KEE T + + + + E A S+ +K
Sbjct: 141 EEEMEIEK-----------IKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMK 189
Query: 1236 ADLQRKEEDYADLKEKL--TDAKKQIKQVQK------EVSVMRDEDKLLRI--------- 1278
LQ KEE + L+ +L T A++ +QV + E V ED+LL++
Sbjct: 190 QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE 249
Query: 1279 ---KINELEKKKNQCSQELDMKQRTIQQLKEQL-----NNQKVEEAIQQYERACKDL-NV 1329
K+ L++K + + L + + + L+++L NQ + + +QQ E L N
Sbjct: 250 MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309
Query: 1330 KEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNN---QR 1386
E E+ ++ LE+ E E+ EE+ L + E+ + +LE++ + Q+
Sbjct: 310 VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQK 369
Query: 1387 SNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQA----KEAENIRNK 1442
E E T + L ELQ + K L++K Q+ ++ E+ +
Sbjct: 370 HKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQ 429
Query: 1443 EMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREER----DQLVAALEIQLKALIS 1498
+ K+ ++ R QQ+E T+ + Q EE + V LE + AL+
Sbjct: 430 KSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL 489
Query: 1499 SNVQKDNEIEQLKRIISETSKIETQIMDIKPK-RISSADPDKLQTEPLSTSFEISRNKIE 1557
S++ E+E+LK +E K+ +QI ++ + R AD + + + + + S + E
Sbjct: 490 SSI----ELEELK---AENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEE 542
Query: 1558 DGSVVLDSCEVSTENDQST---RFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKAR 1614
G VL++ + S + + EI F LQ +
Sbjct: 543 SGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEV--------LD 594
Query: 1615 KRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQA 1674
+++ +ME + + K T FP+ + SS+ +K + S
Sbjct: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
Query: 1675 SIIGVNLATKKKEG--TLQKFGDFLQHSPSILQSKAKKIIE 1713
+ GV L + K++G +L D Q L+ +I+E
Sbjct: 655 NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
Score = 55.1 bits (131), Expect = 6e-07
Identities = 102/554 (18%), Positives = 238/554 (42%), Gaps = 93/554 (16%)
Query: 1223 ELSASSARTQNLKA----------DLQRKEEDYADLKEKLTDAKKQIKQV-----QKEVS 1267
ELS QN++A D++ D++E+L A++ + ++ QK+V
Sbjct: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ 74
Query: 1268 VMRDEDKL---LRIKINELEKKKNQCSQELDMKQRTIQQLKEQ-----LNNQKVEEAIQQ 1319
+ + ++ L + N+++K K +L + I+++K Q + EE + +
Sbjct: 75 LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK 134
Query: 1320 YERACKDLNVKEKIIEDMRMTLEEQEQ-TQVEQDQVLEAKLEEVERLATELEKW------ 1372
++++ + +E IE ++ L+E+E+ Q Q+ +A+ E+ + +TE+E++
Sbjct: 135 HDKSSTE---EEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQ 191
Query: 1373 -KEKCNDLETKNNQRSNKEHEN-------------------NTDVLGKLTNLQDELQESE 1412
+EK + T Q S + E + D L +L D E +
Sbjct: 192 LQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQ 251
Query: 1413 QKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKD 1472
QK ++K E + L+ +A+ + ++ + AE R + QQ ++ + A+
Sbjct: 252 QKLRVLQRKLEEHEESLVGRAQVVDLLQQE--LTAAEQRNQILSQQ--LQQMEAEHNTLR 307
Query: 1473 SDLQKWREERDQLVAALEIQL--KALISSNVQKD--NEIEQLKRIISETSKIETQIMDIK 1528
+ ++ REE L+ +E+++ + L N+Q++ + +EQ ++ +++E++ ++
Sbjct: 308 NTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE 367
Query: 1529 PKRISSADPD-----KLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPEL 1583
K + + LQ K ++ ++ D E + ++ Q+ + + +L
Sbjct: 368 QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQL 427
Query: 1584 E---------IQFTPLQPNKMA-------VKHPGCTTPVTVKIPKARKRKSNEMEEDLVK 1627
+ + PLQ ++ A V + G I +KR +V+
Sbjct: 428 QQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKR--------VVE 479
Query: 1628 CENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIG-VNLATKKK 1686
EN+K A ++++ + + + + K ++ + + +T + S I V++A K+
Sbjct: 480 LENEKGALLLSSIE--LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRS 537
Query: 1687 EGTLQKFGDFLQHS 1700
+ D L+++
Sbjct: 538 SSAEESGQDVLENT 551
>gi|4758648 kinesin family member 5B [Homo sapiens]
Length = 963
Score = 148 bits (373), Expect = 5e-35
Identities = 210/916 (22%), Positives = 380/916 (41%), Gaps = 115/916 (12%)
Query: 235 TLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKF 294
T+ G L + + ++D +M +++F + VS+FEIY + I DL + VS
Sbjct: 94 TMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDL-LDVS--- 149
Query: 295 QKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSI 354
+ L + +D ++K V E + G ++ VA T +N SSRSHSI
Sbjct: 150 --KTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSI 207
Query: 355 FTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCI 414
F + + Q E+++ + + +L L DLAGSE+ KT EG L E NIN SL LG I
Sbjct: 208 FLINVKQ-ENTQTEQKLS-GKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVI 265
Query: 415 NVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKF-- 472
+ L ++ +VP+R+SK+T Q G + +++ S ET + L F
Sbjct: 266 SAL-----AEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQ 320
Query: 473 --SAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISW-ENSLEDL 529
I VCV L + Q K K + +KIL R TI W EN L
Sbjct: 321 RAKTIKNTVCVNVELTAEQWK-----KKYE----KEKEKNKIL---RNTIQWLENELNRW 368
Query: 530 MEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFI------SHEEKRKLLDLIEDL 583
E + + + +E N+E +D+D+ T ++ I + E+RK + I L
Sbjct: 369 RNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKL 428
Query: 584 KKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFK 643
K+L ++K E++ + ++ E++ + +E LL ++N + L
Sbjct: 429 YKQL-DDKDEEINQQSQLVEKLKTQMLD---------QEELLASTRRDQDNMQAEL---- 474
Query: 644 DLVGKCDTREEAAKDICATKVETEEATACLE---LKFNQIKAELAKTKGELIKTKEELKK 700
R +A D A+K E +E LE + ++Q E+ E +EL +
Sbjct: 475 -------NRLQAEND--ASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQ 525
Query: 701 RENESDSLIQELETSNKKIITQNQRIKELINII--DQKEDTINEFQNLKSHMENTFKCND 758
+ S+ EL+ + Q +R E++ + D E I N E T ++
Sbjct: 526 KSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDE 585
Query: 759 KADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAIT 818
+ + L I+ KS++ + KR + E Q T
Sbjct: 586 EFTVARLYISK-------------MKSEVKTMVKRCKQLESTQ----------------T 616
Query: 819 EDQKKSEEVRPNIAEIEDIRVLQENN--EGLRAFLLTIENELKNEKEEKAELNKQIVHFQ 876
E KK EE +A + +R+ Q + L +L +E + + +E L++++V
Sbjct: 617 ESNKKMEENEKELAACQ-LRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELV--- 672
Query: 877 QELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSIT 936
+L EK + + + ++Q+ ++ A +S + +++I L +E+E + IT
Sbjct: 673 -QLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLIT 731
Query: 937 NNVSQIKLMHTKIDELRT----LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGND 992
+ Q + M + + LR L + Q + L L + +D + DL G +
Sbjct: 732 DLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVM-----QDRREQARQDLKGLE 786
Query: 993 YLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEV 1052
V+K+++ + ++ E + S+ + +I LE +E+L
Sbjct: 787 ETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVH 846
Query: 1053 KGYKDENNRLK------EKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGK 1106
K +N L+ EK + + +K E+ +++ KE ++ + E
Sbjct: 847 KQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAV 906
Query: 1107 RALSELTQGVTCYKAK 1122
R+ + +G + AK
Sbjct: 907 RSKNMARRGHSAQIAK 922
Score = 94.0 bits (232), Expect = 1e-18
Identities = 177/923 (19%), Positives = 368/923 (39%), Gaps = 135/923 (14%)
Query: 59 LQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKV 118
++V R RP +SE + TVV+ ++ ++F +V
Sbjct: 9 IKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIA-----------------SKPYAFDRV 51
Query: 119 FGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQG---TEENIGILPRT 175
F +T+Q++ + C + VKD+L+G + IF YG T+SGKT+T +G E +GI+PR
Sbjct: 52 FQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRI 111
Query: 176 LNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEI-ASKSALLRQIKEVTVHNDSDD 234
+ +F+ + NL+ H Y + ++ ++ + SK+ L +VH D +
Sbjct: 112 VQDIFNYIYS---MDENLEFHIKVSYFEIYLDKIRDLLDVSKTNL-------SVHEDKNR 161
Query: 235 TLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKF 294
Y + +E + ++ N V V+ ++ + +F+
Sbjct: 162 VPYVKGCTERFVCSPDEVMDTIDEGKSNR------HVAVTNMNEHSSRSHSIFL----IN 211
Query: 295 QKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSI 354
K++ + Q + G ++ DL + A + K+ + + + L N S
Sbjct: 212 VKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEG 271
Query: 355 FTVKILQIEDSEMSRVIRVS-------ELSLCDLAGSERTMKTQNE---GER---LRETG 401
T + DS+M+R+++ S + +C S +T++ G+R ++ T
Sbjct: 272 ST--YVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTV 329
Query: 402 NINTSLLTLGKCINVLKNSEKSKFQQH-VPFRESKLTHY--------FQSFFNGKGKICM 452
+N L K EK+K ++ + + E++L + + F K +
Sbjct: 330 CVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEA 389
Query: 453 IVNISQCYLAYDETLNVL----KFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNS 508
L D+ + F+ ++ C +E++ K D + N
Sbjct: 390 FTVDKDITLTNDKPATAIGVIGNFTDAERRKC--------EEEIAKLYKQLDDKDEEINQ 441
Query: 509 NSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFI 568
S+++ E +++ E+L+ ++ E L + D + EE K +
Sbjct: 442 QSQLV---------EKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVL 492
Query: 569 SHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQER 628
E+ L + D K + + +K T E+++ + + + A +A+ ++
Sbjct: 493 QALEE---LAVNYDQKSQEVEDK----TKEYELLSDELNQKSATLASIDAELQKLKEMTN 545
Query: 629 EILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTK 688
+ AE ++ KDL E + V+ E T ++ +F + ++K K
Sbjct: 546 HQKKRAAEMMASLLKDLA-------EIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMK 598
Query: 689 GELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKS 748
E+ + K+ E+ +++E + K++ RI + I + + + K
Sbjct: 599 SEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKR 658
Query: 749 HMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI--CSERKRVNENELQQDEPPA 806
+E + D S + + E+ K+ +K+ +E K+ E ++Q
Sbjct: 659 QLE------ESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETH 712
Query: 807 KKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENE-LKNEKEEK 865
+K +SS E + K++ I +++D Q L L +E+E LK +EK
Sbjct: 713 QK---QISSLRDEVEAKAK----LITDLQD----QNQKMMLEQERLRVEHEKLKATDQEK 761
Query: 866 AELNKQIVHFQ--QELSLSEKKNL--TLSKEVQQIQSNYDIAIAELHVQKSKNQE----- 916
+ ++ Q +E + + K L T++KE+Q + + + + +L + K+ E
Sbjct: 762 SRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDD 821
Query: 917 ------QEEKIMKLSNEIETATR 933
Q++KI L N +E T+
Sbjct: 822 TGGSAAQKQKISFLENNLEQLTK 844
Score = 80.5 bits (197), Expect = 1e-14
Identities = 146/746 (19%), Positives = 292/746 (39%), Gaps = 136/746 (18%)
Query: 893 VQQIQSNYDIAIAELHVQKSKN---------QEQEEKIMKLSNEIETATRSITNNVSQIK 943
+ + +SN +A+ ++ S++ QE + KLS ++ + + VS+
Sbjct: 183 IDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTG 242
Query: 944 LMHTKIDELRTLD-SVSQISNIDLLNLRDLSNGS-----EEDNLPNTQLDLLGND----Y 993
+DE + ++ S+S + N+ + L+ GS + + D LG +
Sbjct: 243 AEGAVLDEAKNINKSLSALGNV----ISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTI 298
Query: 994 LVSKQVKEYRIQEPNRENSFHSSIEAIWEE-CKEIVKASSKKSHQIEELEQQIEKLQAEV 1052
++ Y E F + I C + + + + E+ +++ + L+ +
Sbjct: 299 VICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTI 358
Query: 1053 KGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEE-----LQEKNVTLDVQIQHVVEGKR 1107
+ ++E NR + E D+ +++ ++ + +K T I + + +R
Sbjct: 359 QWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAER 418
Query: 1108 ALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEH 1167
E + K+ E ++Q VE KL+ +L++E ++ R+ Q
Sbjct: 419 RKCEEEIAKLYKQLDDKDEEINQQSQLVE-----KLKTQMLDQEELLASTRRDQDNMQAE 473
Query: 1168 LQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS 1227
L L + KEE+ ++ L+++ K +E E +E E L +EL+
Sbjct: 474 LNR-------LQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQK 526
Query: 1228 SARTQNLKADLQRKEE------------------DYAD------------------LKEK 1251
SA ++ A+LQ+ +E D A+ + E+
Sbjct: 527 SATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEE 586
Query: 1252 LTDAKKQIKQVQKEVSVMRDEDKLLRI-------KINELEKKKNQCSQELDMKQRTIQQL 1304
T A+ I +++ EV M K L K+ E EK+ C + + I+ L
Sbjct: 587 FTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSL 646
Query: 1305 KEQLNN-----QKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKL 1359
E L N +++EE++ L +EK + +M + QT E Q +E ++
Sbjct: 647 TEYLQNVEQKKRQLEESVDALSEELVQLRAQEK-VHEMEKEHLNKVQTANEVKQAVEQQI 705
Query: 1360 E--------EVERLATELEKWKEKCNDLETKN------NQRSNKEHE-------NNTDVL 1398
+ ++ L E+E + DL+ +N +R EHE + L
Sbjct: 706 QSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKL 765
Query: 1399 GKLTNLQDELQESEQKYNADRKKWLEEKMM----------------LITQAKEAENIRNK 1442
+LT +QD +++ Q K LEE + L T+ K++ I +
Sbjct: 766 HELTVMQDRREQARQDL-----KGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSD 820
Query: 1443 EMKKYAEDRERFFKQQNEMEILT---AQLTEKDSDLQKWREERDQLVAALEIQLKALISS 1499
+ A +++ +N +E LT QL ++DL+ + ++ + A ++KAL S+
Sbjct: 821 DTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESA 880
Query: 1500 -NVQKDNEIEQLKRIISETSKIETQI 1524
K+N KR E +I+ +
Sbjct: 881 LKEAKENASRDRKRYQQEVDRIKEAV 906
Score = 72.0 bits (175), Expect = 5e-12
Identities = 119/541 (21%), Positives = 231/541 (42%), Gaps = 103/541 (19%)
Query: 1184 KLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK------EELSASSARTQ-NLKA 1236
K +EEI +L L D K+EE Q EKLK EEL AS+ R Q N++A
Sbjct: 420 KCEEEIAKLYKQLDD-------KDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQA 472
Query: 1237 DLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDM 1296
+L R + + KE++ K++ Q +E++V D Q SQE++
Sbjct: 473 ELNRLQAENDASKEEV----KEVLQALEELAVNYD-----------------QKSQEVED 511
Query: 1297 KQRTIQQLKEQLNN------------QKVEEAI-QQYERACKDLNVKEKIIEDMRMTLEE 1343
K + + L ++LN QK++E Q +RA + + K + ++ + +
Sbjct: 512 KTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGN 571
Query: 1344 QEQTQVEQDQVLEAKLE----EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVL- 1398
+ Q E +++ + + ++ +E++ ++C LE+ + + K EN ++
Sbjct: 572 NDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAA 631
Query: 1399 ---------GKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAE 1449
K+ +L + LQ EQK K+ LEE + +++ E +R +E K +
Sbjct: 632 CQLRISQHEAKIKSLTEYLQNVEQK-----KRQLEESVDALSE--ELVQLRAQE-KVHEM 683
Query: 1450 DRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAAL--EIQLKALISSNVQKDN-- 1505
++E K Q E+ A + +Q RE + +++L E++ KA + +++Q N
Sbjct: 684 EKEHLNKVQTANEVKQA----VEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQK 739
Query: 1506 ----------EIEQLKRIISETSKIETQIMDIKPKRISSADP----DKLQTEPLSTSFEI 1551
E E+LK E S+ ++ ++ +R + ++ + L T +
Sbjct: 740 MMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNL 799
Query: 1552 SRNKIED-GSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQP----NKMAVKHPG---CT 1603
+ ++D + V S E+ +++ + K ++ L+ +K V+ C
Sbjct: 800 RKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCE 859
Query: 1604 TPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPS 1663
P K +A + +E L E K+NA+ R ++ DR + + +A R
Sbjct: 860 LPKLEKRLRATAERVKALESALK--EAKENAS-RDRKRYQQEVDRIKEAVRSKNMARRGH 916
Query: 1664 S 1664
S
Sbjct: 917 S 917
Score = 49.7 bits (117), Expect = 3e-05
Identities = 86/453 (18%), Positives = 183/453 (40%), Gaps = 68/453 (15%)
Query: 1370 EKWKEKCNDLETKNNQRSNK----EHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEE 1425
E+WK+K + KN N E+E N G+ + ++ K A+ + + +
Sbjct: 338 EQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFD----KEKANLEAFTVD 393
Query: 1426 KMMLITQAKEAE------NIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWR 1479
K + +T K A N + E +K E+ + +KQ L +KD ++ +
Sbjct: 394 KDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQ----------LDDKDEEINQQS 443
Query: 1480 EERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSA---D 1536
+ ++L + Q + L S+ +DN +L R+ +E + ++ ++ A D
Sbjct: 444 QLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYD 503
Query: 1537 PDKLQTEPLSTSFEISRNKIEDGSVVLDS--CEVSTENDQSTRFPKPELEIQFTPLQP-- 1592
+ E + +E+ +++ S L S E+ + + K E+ + L+
Sbjct: 504 QKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLA 563
Query: 1593 ------NKMAVKHPGCTTPVTVKIPKAR---KRKSNEMEEDLVKCENKKNATPRTNLKFP 1643
VK P T + + AR + +E++ + +C+ ++ +N K
Sbjct: 564 EIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKM- 622
Query: 1644 ISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSI 1703
+ N ++ I K SL N+ KK++ L++ D L S +
Sbjct: 623 ---EENEKELAACQLRISQHEAKIKSLTEYLQ----NVEQKKRQ--LEESVDAL--SEEL 671
Query: 1704 LQSKAKKIIETMSSSKLSNVEAS---KENVSQPKRAKRKLYTSEISS------------- 1747
+Q +A++ + M L+ V+ + K+ V Q ++ R+ + +ISS
Sbjct: 672 VQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLIT 731
Query: 1748 PIDISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
+ Q ++++Q+ +H+ +K + K+ K
Sbjct: 732 DLQDQNQKMMLEQERLRVEHEKLKATDQEKSRK 764
>gi|13699824 kinesin family member 11 [Homo sapiens]
Length = 1056
Score = 146 bits (368), Expect = 2e-34
Identities = 214/905 (23%), Positives = 386/905 (42%), Gaps = 102/905 (11%)
Query: 265 NSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSK 324
N +FSV VS EIYNE ++DL P S ++ +M ++ +G IK L+ I V +
Sbjct: 150 NGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGV-IIKGLEEITVHNKD 208
Query: 325 EAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDS-EMSRVIRVSELSLCDLAG 383
E Y++L+ G ++ A T +N SSRSHS+F+V I E + + ++++ +L+L DLAG
Sbjct: 209 EVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAG 268
Query: 384 SERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSF 443
SE ++ +R RE GNIN SLLTLG+ I L HVP+RESKLT Q
Sbjct: 269 SENIGRSGAVDKRAREAGNINQSLLTLGRVITALVER-----TPHVPYRESKLTRILQDS 323
Query: 444 FNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVS 503
G+ + +I IS L +ETL+ L+++ A+ + +N K + ++++
Sbjct: 324 LGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIE 383
Query: 504 LDSNSNSKILNVKRATISWEN----SLEDLMEDEDLVEELEN---AEETQNVETKL---- 552
+ IS EN S + +++E +VE +E EE N T+L
Sbjct: 384 RLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDN 443
Query: 553 ---LDE---DLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVT 606
LD+ DL +E + H ++ KL + E+ + +EKL
Sbjct: 444 KNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTV 503
Query: 607 QEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVET 666
+E T + + L +++ + + NAE + K+L + EE KD + +
Sbjct: 504 EETT----KDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAM 559
Query: 667 EEATACL--ELKFNQIKAELAKTK---GELIKTKEELKKRENESDSLI---QELETSNKK 718
E L L + + A T G L E + ++ ++I Q L +K
Sbjct: 560 LEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKT 619
Query: 719 IITQNQRIKELINIIDQKEDTINEFQNLKS-HMENTFKCNDKADTSSLIINNKLICNETV 777
+ ++ELIN++ K D ++ + + S + + K N + I L + +
Sbjct: 620 V------LQELINVL--KTDLLSSLEMILSPTVVSILKINSQL---KHIFKTSLTVADKI 668
Query: 778 EVPKDS----KSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVR-PNIA 832
E K S +C+ N +ELQ++ + S +TED K ++ +
Sbjct: 669 EDQKKELDGFLSILCN-----NLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELC 723
Query: 833 EI-----EDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNL 887
++ E L+E E ++ L +++ + +++ K +NK H Q+ + S+
Sbjct: 724 KLMNLWTERFCALEEKCENIQKPLSSVQENI--QQKSKDIVNKMTFHSQKFCADSD---- 777
Query: 888 TLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNE--IETATRSITNNVSQIKLM 945
S+E++ + E K EKI + + + TR++ + + +
Sbjct: 778 GFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSL 837
Query: 946 HTKIDELRT-LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRI 1004
+ + EL L+ VSQ ++ + S+G + + + N +L + E ++
Sbjct: 838 NEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAH------EKQHNIFLDQMTIDEDKL 891
Query: 1005 QEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIE---KLQAEVKGYKDENNR 1061
N E E +K K + E + +++ + K Y +
Sbjct: 892 IAQNL-------------ELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTL 938
Query: 1062 LKEKEHKNQDDLLKEKE-TLIQQLKEELQEKNVTL-DVQIQHVVEGKRALSELTQ----- 1114
++ + ++ D LK K+ L+ L K T+ DV ++ V G+ L+Q
Sbjct: 939 VRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVD 998
Query: 1115 -GVTC 1118
GV C
Sbjct: 999 AGVDC 1003
Score = 73.9 bits (180), Expect = 1e-12
Identities = 59/212 (27%), Positives = 104/212 (49%), Gaps = 31/212 (14%)
Query: 46 PNTEANSFESKDY-LQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEK 104
PN+ A E K +QV +R RPF +E++ + V V KE G L++K
Sbjct: 5 PNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVEC----DPVRKEVSVRTGGLADK 60
Query: 105 SSGQMAQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQG 164
SS + ++F VFG +T Q + ++ + + +++ G + IF YG T +GKT+T +G
Sbjct: 61 SS---RKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEG 117
Query: 165 T---------EEN--IGILPRTLNVLFDSLQE---RLYTKMNLKPHRSREYLRL----SS 206
EE+ GI+PRTL+ +F+ L + K++L + E L S
Sbjct: 118 ERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD 177
Query: 207 EQEKEEI-----ASKSALLRQIKEVTVHNDSD 233
E+ ++ + +++ ++E+TVHN +
Sbjct: 178 VSERLQMFDDPRNKRGVIIKGLEEITVHNKDE 209
Score = 50.4 bits (119), Expect = 1e-05
Identities = 101/509 (19%), Positives = 206/509 (40%), Gaps = 58/509 (11%)
Query: 1025 KEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENN-RLKEKEHKNQDDLLKEKETLIQQ 1083
K V K I+E ++IE+L+ ++ +++N + E+ + L +E I +
Sbjct: 362 KPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVE 421
Query: 1084 LKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKL 1143
L E++ L+ + ++ K +EL Q + + K +ELET TQK H +
Sbjct: 422 LIEKIGAVEEELNRVTELFMDNK---NELDQCKSDLQNKTQELET---TQK----HLQET 471
Query: 1144 EQDILEKESIILKLE---RNLKEFQEHLQDSVKNT-KDLNVKELKL--KEEITQLTNNLQ 1197
+ ++++E I LE L + L ++V+ T KD++ KL K+ + Q Q
Sbjct: 472 KLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQ 531
Query: 1198 DM--KHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEE--------DYAD 1247
D+ K+L L EE + + K K L NL + +
Sbjct: 532 DIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTS 591
Query: 1248 LKEKLTDAKKQI-KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE 1306
+ E ++ QI + KE S+ + +L+ IN L K S E+ + + LK
Sbjct: 592 IPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVL-KTDLLSSLEMILSPTVVSILK- 649
Query: 1307 QLNNQ-------------KVEEAIQQYERACKDL--NVKEKIIEDMRMTLEEQEQTQVEQ 1351
+N+Q K+E+ ++ + L N+ E + +E Q+Q
Sbjct: 650 -INSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLT 708
Query: 1352 DQVLEAKLEEVERLATELEKW-------KEKCNDLETKNNQRSNKEHENNTDVLGKLTNL 1404
+ + K + L + W +EKC +++ + + + D++ K+T
Sbjct: 709 EDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFH 768
Query: 1405 QDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEIL 1464
+ ++ + + + +E L+ ++ + + N ++K +++ E+ + N +
Sbjct: 769 SQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVY 828
Query: 1465 -----TAQLTEKDSDLQKWREERDQLVAA 1488
+ L E++ +L E Q A
Sbjct: 829 FSEQWVSSLNEREQELHNLLEVVSQCCEA 857
Score = 37.7 bits (86), Expect = 0.10
Identities = 35/175 (20%), Positives = 78/175 (44%), Gaps = 33/175 (18%)
Query: 1423 LEEKMMLITQAKEAENIRNKE-----------MKKYAEDRERF-------------FKQQ 1458
LEE + + A A+NI NK +K+Y E+ ER + +
Sbjct: 343 LEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISE 402
Query: 1459 NEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETS 1518
+++ +LT ++ + + E+ + A+E +L + + NE++Q K +
Sbjct: 403 ENFRVMSGKLTVQEEQIVELIEK----IGAVEEELNRVTELFMDNKNELDQCKSDLQN-- 456
Query: 1519 KIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIED-GSVVLDSCEVSTEN 1572
+TQ ++ K + ++ E ++++ E + K+ D S +L++ E +T++
Sbjct: 457 --KTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKD 509
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 145 bits (365), Expect = 4e-34
Identities = 240/1171 (20%), Positives = 487/1171 (41%), Gaps = 197/1171 (16%)
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
L+ + + EL EL+K KE+ K E E ++E+E +++++ + + E +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGE----LEEMERKHQQLLEEKNILAEQLQA-- 898
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRV 794
+ + E + +++ + + E E+ D +S++ E +R
Sbjct: 899 -ETELFAEAEEMRARLAAKKQ-------------------ELEEILHDLESRVEEEEER- 937
Query: 795 NENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTI 854
N++ Q+E KK H+ E+Q EE ++E + + + + +L +
Sbjct: 938 --NQILQNEK--KKMQAHIQDL--EEQLDEEEGARQKLQLEKVTA-EAKIKKMEEEILLL 990
Query: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
E++ +EK + +I +L+ E+K +K + +I++ ++ I++L + K
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQLAEEEEK----AKNLAKIRNKQEVMISDLEERLKKE 1046
Query: 915 QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSN 974
++ +++ K +++ T + + +++++ +IDEL+ Q++ + L+
Sbjct: 1047 EKTRQELEKAKRKLDGETTDLQDQIAELQ---AQIDELKL-----QLAKKEEELQGALAR 1098
Query: 975 GSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKK 1034
G +E N L K V+E + Q + F S KAS K
Sbjct: 1099 GDDETLHKNNAL----------KVVRELQAQIAELQEDFESE------------KASRNK 1136
Query: 1035 SH-QIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLK------EE 1087
+ Q +L +++E L+ E++ D +E K + ++ + K+ L ++ K ++
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 1088 LQEKNVT----LDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAK- 1142
+++++ T L Q++ K L + QG+ ++ +L+ K E H K
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 1143 -------LEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNN 1195
L + E + + ++L + Q L + ++ K +K ++ L +
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 1196 LQDMKHLLQ------------LKEEEEETN-----RQETEKLKEELSASSARTQNLKADL 1238
LQD + LLQ +++ EEE N ++E E+ ++ L Q+ AD
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 1239 QRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQ 1298
++K +D E L +AKK++ + + +S R E+K L ++LEK KN+ QELD
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALS-QRLEEKAL--AYDKLEKTKNRLQQELD--- 1430
Query: 1299 RTIQQLKEQLNNQK-VEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEA 1357
L L++Q+ V +++ ++ L +EK I EE+++ + E +
Sbjct: 1431 ----DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS--ARYAEERDRAEAEARE---- 1480
Query: 1358 KLEEVERLATELEKWKEKCNDLETKNNQ-RSNKEH--ENNTDVLGKLTNLQDELQESEQK 1414
K + LA LE+ E + E +N Q R++ E + DV + L+ + EQ+
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ 1540
Query: 1415 YNADRKKW--LEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNE--MEILTAQLTE 1470
R + LE+++ AK + + MK E + +QNE +L Q+ E
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 1471 KDSDLQKWREERDQLVAA---LEIQLKAL----ISSNVQKDNEIEQLKRIISETSKIETQ 1523
+++L+ R++R VA+ +EI LK L ++N +D I+QL+++ ++ + +
Sbjct: 1601 LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE 1660
Query: 1524 IMDIK-------------PKRISSADPDKLQ-TEPLSTSFEISRNKIEDGSVVLDSCEVS 1569
+ + + K++ S + + LQ E L++S R+ ++ + D S
Sbjct: 1661 LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 1570 TENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCE 1629
+ K LE + L+ E+EE+ E
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLE---------------------------EELEEEQSNME 1753
Query: 1630 NKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGT 1689
+ +T L+ D N+ + E R +++K+ + R Q L K
Sbjct: 1754 LLNDRFRKTTLQV---DTLNAELAAE-----RSAAQKSDNARQQLERQNKELKAK----- 1800
Query: 1690 LQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPI 1749
LQ ++SK K I + +K+ +E E ++ + A KL
Sbjct: 1801 -------LQELEGAVKSKFKATISAL-EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852
Query: 1750 DISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
+I QV + + Q+ K R K K
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Score = 139 bits (349), Expect = 3e-32
Identities = 250/1164 (21%), Positives = 460/1164 (39%), Gaps = 201/1164 (17%)
Query: 509 NSKILNVKRATISWENSLEDL-MEDEDLVEELENAEETQNVETKLLDE------------ 555
+ ++L VK E LE++ + + L+EE E ET+L E
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 556 --------DLDKTLEENKAF--ISHEEKRKLLDLIEDLKKKLINE-------KKEKLTLE 598
DL+ +EE + I EK+K+ I+DL+++L E + EK+T E
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 599 FKIREEVTQEFTQYWAQREADFKETLLQEREIL---------EENAERRLAIFKDLVGKC 649
KI+ ++ +E Q KE L E I EE A+ I
Sbjct: 978 AKIK-KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMI 1036
Query: 650 DTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLI 709
EE K T+ E E+A L+ + ++ ++A+ + ++ + K +L K+E E L
Sbjct: 1037 SDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE---LQ 1093
Query: 710 QELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINN 769
L + + + +N +K + + Q + +F++ K+ K K D S +
Sbjct: 1094 GALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK--QKRDLSEELEAL 1151
Query: 770 KLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRP 829
K +T++ + E + E E+ + + A+ E+ K E
Sbjct: 1152 KTELEDTLDTTAAQQ-----ELRTKREQEVAE-----------LKKALEEETKNHE---- 1191
Query: 830 NIAEIEDIR--------VLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSL 881
A+I+D+R L E E + F +E + + + EL ++ QQ +
Sbjct: 1192 --AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 882 SEKKNLTLSKEVQQIQ---SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNN 938
SE K L +VQ++ S D EL + SK Q + + + L E E +
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 939 VSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQ 998
+ ++ +L+ + Q LNL EE+
Sbjct: 1310 AASLE------SQLQDTQELLQEETRQKLNLSSRIRQLEEE----------------KNS 1347
Query: 999 VKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDE 1058
++E + +E + + A+ + + K IE LE+ +KL +K +
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL---LKDAEAL 1404
Query: 1059 NNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTC 1118
+ RL+EK D L K K +L++EL + V LD Q ++ S L
Sbjct: 1405 SQRLEEKA-LAYDKLEKTK----NRLQQELDDLTVDLDHQ-------RQVASNL------ 1446
Query: 1119 YKAKIKELETILETQKVECSHSA----KLEQDILEKESIILKLERNLKEFQEHLQDSVKN 1174
+ K K+ + +L +K + A + E + EKE+ L L R L+E E ++ +
Sbjct: 1447 -EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ 1505
Query: 1175 TKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNL 1234
K L L + N+ +++ + E++ E R + E+L++EL A+ L
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 1235 KADLQRKEEDY---ADLKEKLTDAKKQ--IKQVQKEVSVMRDEDKLLRIKINELEKKKNQ 1289
+ ++Q + + +++ + KK+ IKQV++ + + DE K + + KKK
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV--ASKKK-- 1621
Query: 1290 CSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQV 1349
E+D+K Q +E A + + K L + ++D + LEE ++
Sbjct: 1622 --MEIDLKDLEAQ----------IEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD 1669
Query: 1350 E---QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQD 1406
E Q + E KL+ +E +L++ E +++R+ + E D L D
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQLQE--------ELASSERARRHAEQERD------ELAD 1715
Query: 1407 ELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTA 1466
E+ S + + L+EK L + + E +E +RF K +++ L A
Sbjct: 1716 EITNSA----SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 1467 QLTEKDSDLQKWREERDQL-------------------------VAALEIQLKALISSNV 1501
+L + S QK R QL ++ALE ++ L
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 1502 QKDNEIEQLKRIISET-SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGS 1560
Q+ E +++ T K++ M ++ +R AD K Q E + + + ++E+
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQVEDER-RHADQYKEQMEKANARMKQLKRQLEEAE 1890
Query: 1561 VVLDSCEVSTENDQSTRFPKPELE 1584
E +T + S R + EL+
Sbjct: 1891 ------EEATRANASRRKLQRELD 1908
Score = 129 bits (323), Expect = 3e-29
Identities = 203/984 (20%), Positives = 418/984 (42%), Gaps = 141/984 (14%)
Query: 530 MEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLIN 589
ME+E L+ E +N++ + E KL++ D+ E + EEK K L I + ++ +I+
Sbjct: 983 MEEEILLLEDQNSKFIK--EKKLME---DRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 590 EKKEKLTLEFKIREEV----------TQEFTQYWAQREADFKETLLQEREILEE------ 633
+ +E+L E K R+E+ T + A+ +A E LQ + EE
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097
Query: 634 -------NAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAK 686
+ L + ++L + +E + A++ + E+ L + +K EL
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157
Query: 687 TKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNL 746
T +E KRE E L + LE K Q Q ++ Q+ T E +
Sbjct: 1158 TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR-------QRHATALEELSE 1210
Query: 747 KSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERK-----------RVN 795
+ FK N + + L +NK + E V+V + K++ +RK +V+
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACE-VKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Query: 796 ENELQQDEPPAKKGSI-----HVSSAITEDQKKSEEVRPNIAEIED-----IRVLQENNE 845
E + + E K + +VS+ + E +KK + + A +E +LQE
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR 1329
Query: 846 ---GLRAFLLTIE---NELKNEKEEKAE----LNKQIVHFQQELSLSEKKNLTLSKEVQQ 895
L + + +E N L+ ++EE+ E L KQ++ Q +L+ ++KK + ++
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK---VDDDLGT 1386
Query: 896 IQSNYDIAIAELHVQKSKNQEQEEKIM----------KLSNEIETATRSITNN---VSQI 942
I+S + L ++ +Q EEK + +L E++ T + + S +
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL 1446
Query: 943 KLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEY 1002
+ K D+L +++ +I + E T+ L + + KE
Sbjct: 1447 EKKQKKFDQL-----LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE- 1500
Query: 1003 RIQEPNRE-----NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKD 1057
+ N++ SS + + + E+ K+ Q+EE+ Q+E+L+ E++ +D
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED 1560
Query: 1058 ENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVT 1117
RL+ N + + E +Q E+ +EK L I+ V E + L + +
Sbjct: 1561 AKLRLE----VNMQAMKAQFERDLQTRDEQNEEKKRLL---IKQVRELEAELEDERKQRA 1613
Query: 1118 CYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKD 1177
A K++E L+ + + + K +++++ + KL+ +K++Q L+++ + +
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ---LRKLQAQMKDYQRELEEARASRDE 1670
Query: 1178 LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKAD 1237
+ + + ++++ L + ++ L E QE ++L +E++ S++ L +
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 1238 LQRKEEDYADLKEKLTDAKK--------------QIKQVQKEVSVMRD------------ 1271
+R E A L+E+L + + Q+ + E++ R
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Query: 1272 --EDKLLRIKINELE-KKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLN 1328
++K L+ K+ ELE K++ + + I QL+EQL + E A A K +
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA-----AANKLVR 1845
Query: 1329 VKEKIIEDMRMTLEEQEQ---TQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQ 1385
EK ++++ M +E++ + EQ + A++++++R E E+ + N K +
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905
Query: 1386 RSNKEHENNTDVLGKLTNLQDELQ 1409
+ E N + +++ L++ L+
Sbjct: 1906 ELDDATEANEGLSREVSTLKNRLR 1929
Score = 107 bits (268), Expect = 8e-23
Identities = 173/841 (20%), Positives = 361/841 (42%), Gaps = 109/841 (12%)
Query: 476 AQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMED--- 532
A K + DTL+++ + K Q+V+ + ++ T + E ++D+ +
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQEVAELKKA------LEEETKNHEAQIQDMRQRHAT 1203
Query: 533 --EDLVEELENAEETQ-NVETKLLDEDLD--------KTLEENKAFISHEEKRKLLDL-I 580
E+L E+LE A+ + N+E + D K L++ KA E KRK LD +
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA--ESEHKRKKLDAQV 1261
Query: 581 EDLKKKL---------INEKKEKLTLEFK----IREEVTQEFTQYWAQREADFKETLLQE 627
++L K+ + EK KL E + EE ++ ++ A+ A + L
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF-AKDAASLESQLQDT 1320
Query: 628 REILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKT 687
+E+L+E ++L +L + EE + + E EEA LE + ++++LA T
Sbjct: 1321 QELLQEETRQKL----NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 688 KGELIKTKEELKKRENESDSLIQELETSNKKIITQ----NQRIKELINIIDQKEDTINEF 743
K K+ ++ I+ LE + KK++ +QR++E D+ E T N
Sbjct: 1377 K-----------KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL 1425
Query: 744 QNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDE 803
Q + T + + +S + + ++ + K ++ ER R E E ++ E
Sbjct: 1426 QQELDDL--TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA-EAEAREKE 1482
Query: 804 PPAKKGSIHVSSAITEDQKKSEEV-RPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEK 862
A + ++ A+ E + EE R N D+ L + + + + +E + +
Sbjct: 1483 TKA----LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 863 EEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIM 922
++ E+ Q+ + EL +E L L +Q +++ ++ +L + +N+E++ ++
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE---RDLQTRDEQNEEKKRLLI 1595
Query: 923 K----LSNEIETATRSITNNVSQIKLMHTKIDELRT-LDSVSQISNIDLLNLRDLSNGSE 977
K L E+E + V+ K M + +L +++ ++ + + LR L +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 978 EDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQ 1037
+ + ++ + E +++ S + I + EE +A +
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLK------SLEAEILQLQEELASSERARRHAEQE 1709
Query: 1038 IEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV 1097
+EL +I + DE RL+ + + +++L +E+++ ++ L + ++ + +D
Sbjct: 1710 RDELADEITNSASGKSALLDEKRRLEARIAQLEEEL-EEEQSNMELLNDRFRKTTLQVDT 1768
Query: 1098 QIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKL 1157
+ + A + + + KEL+ L Q++E + +K + I E+ I +L
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKL--QELEGAVKSKFKATISALEAKIGQL 1826
Query: 1158 ERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQET 1217
E L+ QE + + N K + E KLKE Q+ E R+
Sbjct: 1827 EEQLE--QEAKERAAAN-KLVRRTEKKLKEIFMQV------------------EDERRHA 1865
Query: 1218 EKLKEELSASSARTQNLKADLQRKEEDYA-------DLKEKLTDAKKQIKQVQKEVSVMR 1270
++ KE++ ++AR + LK L+ EE+ L+ +L DA + + + +EVS ++
Sbjct: 1866 DQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
Query: 1271 D 1271
+
Sbjct: 1926 N 1926
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 145 bits (365), Expect = 4e-34
Identities = 197/936 (21%), Positives = 414/936 (44%), Gaps = 114/936 (12%)
Query: 680 IKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDT 739
+ ELA K ++ + ++EL+++ + QELE ++ +R+++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL----KRLQQ----------- 293
Query: 740 INEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENEL 799
E NL S + D+ D + + V V K +S++ ++R+++ E
Sbjct: 294 --ENMNLLSDARSARMYRDELDA---------LREKAVRVDK-LESEVSRYKERLHDIEF 341
Query: 800 QQDEPPAKKGSIHV---SSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIEN 856
+ K V + + EDQ + R + + L++ N L+A L +E
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARS-----DKLHELEKENLQLKAKLHDMEM 396
Query: 857 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 916
E ++++ EL ++ + + S ++L L E++QI +++ A QKS E
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP---QKSLGHE 453
Query: 917 QEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGS 976
E ++E +S+T V +++ T+DSV N +
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELR---------TTVDSVEG-------NASKILKME 497
Query: 977 EEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSH 1036
+E+ + ++++L N+ + KQ +Q + +A E+ E ++ +S++
Sbjct: 498 KENQRLSKKVEILENEIVQEKQ----SLQNCQNLSKDLMKEKAQLEKTIETLRENSER-- 551
Query: 1037 QIEELEQQIEKLQAEVKGYKDENN-----RLK--EKEHKNQDDLLKEKETLIQQLKEELQ 1089
QI+ LEQ+ E L V + + R+K EKE+K + +KE + + +++ E +
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 1090 EKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILE 1149
+ + +++H E EL + + + + L+ + K+ C LEQ+ E
Sbjct: 612 Q----IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 1150 KESIILKLERNLKEFQE---HLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLK 1206
E KL++ L F+ L+ K L+ + L+L+ + L M LQL+
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLE 726
Query: 1207 EEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEV 1266
+E E+ +++ +K E L AS +T+ L+ Q + + L++ L ++ K+I+Q++ E+
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 1267 SVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 1326
+ E++ L+ + +EL + + ++QL+++ N+ +E+ Q E+ K
Sbjct: 787 QDLEMENQTLQKNL-----------EELKISSKRLEQLEKE--NKSLEQETSQLEKDKKQ 833
Query: 1327 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLE-EVERLATELEKWKEKCNDLETKNNQ 1385
L + K + E + T +E++ V LE E + L+ E+ +KE C + K +
Sbjct: 834 LEKENKRLRQQ----AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC--VRLKELE 887
Query: 1386 RSNKEHENNTDV-LGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEM 1444
+ NKE + + L L+++L + EK+ + E + + E+
Sbjct: 888 KENKELVKRATIDIKTLVTLREDL--------------VSEKLKTQQMNNDLEKLTH-EL 932
Query: 1445 KKYAEDRERFFKQQNEMEILTAQLTEK--DSDLQKWREERDQLVAALEIQLKALISSNVQ 1502
+K ++ER + + +L E +S L+K E +++ +AALE +L+ + N Q
Sbjct: 933 EKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 992
Query: 1503 KDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVV 1562
E++ +K+ + + + ++ S + +K + E T+ E+ + K V
Sbjct: 993 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVE 1052
Query: 1563 LDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVK 1598
++ + E Q+ + +LE Q LQ +A++
Sbjct: 1053 RNNATLQAEK-QALKTQLKQLETQNNNLQAQILALQ 1087
Score = 142 bits (357), Expect = 4e-33
Identities = 227/1105 (20%), Positives = 470/1105 (42%), Gaps = 175/1105 (15%)
Query: 526 LEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKK 585
+E+L ED ++ E + E Q T+ + L + +EN + + K +++ D+ +
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN---LQLKAKLHDMEMERDMDR 402
Query: 586 KLINE-KKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQE------REILEENAERR 638
K I E +E +TLE ++ + + W + L + E+ E + R
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 639 LAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKT----KGELIKT 694
L + + T EE T V++ E A LK + L+K + E+++
Sbjct: 463 LKLEMENQSLTKTVEELR-----TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 695 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTF 754
K+ L+ +N S L++E K I T + + I I++Q+ + +N+ S +
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ---TVSSLRQRS 574
Query: 755 KCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVS 814
+ + +A + NK++ +E+++ SKI E++++ + EL+ + ++ +
Sbjct: 575 QISAEARVKDIEKENKIL-HESIKETSSKLSKIEFEKRQIKK-ELEHYKEKGERAE-ELE 631
Query: 815 SAITEDQKKSEEVRPNIAEI----EDIRVLQENNEGLRAFLLTIEN-ELKNEKEEKAELN 869
+ + +K++E ++ I + E I L++ N L EN +LK + L
Sbjct: 632 NELHHLEKENELLQKKITNLKITCEKIEALEQENSELER-----ENRKLKKTLDSFKNLT 686
Query: 870 KQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 929
Q+ ++E S +++NL L + V+ ++ + +A+L ++ + + ++E++ K
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCA-SMKMAQLQLENKELESEKEQLKK------ 739
Query: 930 TATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLL 989
+ +K K + L I N L + SN + L + DL
Sbjct: 740 --------GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN-KKIQQLESELQDLE 790
Query: 990 GNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL- 1048
+ + K ++E +I +E + +E K + + +S+ ++LE++ ++L
Sbjct: 791 MENQTLQKNLEELKISSKR--------LEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 1049 -QAEVKGYKDENNRLK----EKEHKN---QDDLLKEKETLIQQLKEELQE--KNVTLDVQ 1098
QAE+K E N +K EKE+K + + KE +++L++E +E K T+D+
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI- 901
Query: 1099 IQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158
+ L L + + K K +++ LE + +H +LE+ L KE ++ +
Sbjct: 902 --------KTLVTLREDLVSEKLKTQQMNNDLE----KLTH--ELEKIGLNKERLLHDEQ 947
Query: 1159 RNLKEFQEHLQDSVKNT--KDLNVKELK---LKEEITQLTNNLQDMKHLLQLKEEEEET- 1212
+ L+ +++T K L +KE K L+ + + TN Q ++ L+ ++ E
Sbjct: 948 STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1007
Query: 1213 -NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD 1271
RQ+ E++ + S + + Q + +K++L + V++ + ++
Sbjct: 1008 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE-------VERNNATLQA 1060
Query: 1272 EDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKE 1331
E + L+ ++ +LE + N ++ QR L+EQ + + A Q E + + +
Sbjct: 1061 EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN-SQST 1119
Query: 1332 KIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEH 1391
++ L +Q + E + V++ + E+++ L L K EK L ++R E+
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKER-EDLKSLYDSLIKDHEKLELL----HERQASEY 1174
Query: 1392 ENNTDVLGKLT----NLQDELQESEQKYNA--DRKKWLE--EKMMLITQAKEAENIRNKE 1443
E+ G L NL+ E ++ E +YN +K LE EKM+ + Q K +N E
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1234
Query: 1444 M-----KKYAEDRER----FFKQQNEMEILTA--------------QLTEKDSDLQKWRE 1480
KK + +R + + E E+L + T +++ K +E
Sbjct: 1235 TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1294
Query: 1481 ERDQL-------------------------------VAALEIQLKALISSN--------V 1501
+ QL + L +Q + L+ N V
Sbjct: 1295 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1354
Query: 1502 QKDNEIEQLKRIISETSKIETQIMD 1526
++ I++L + + K+E +IMD
Sbjct: 1355 EQRQYIDKLNELRRQKEKLEEKIMD 1379
Score = 131 bits (329), Expect = 7e-30
Identities = 240/1126 (21%), Positives = 491/1126 (43%), Gaps = 149/1126 (13%)
Query: 664 VETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQN 723
VE +A A K +++ EL + +L+ K+EL++ E E ++ L+ N +++
Sbjct: 251 VELADAKA----KIRRLRQELEEKTEQLLDCKQELEQMEIE----LKRLQQENMNLLSDA 302
Query: 724 QRIKELINIIDQKEDTINEFQNLKSHMEN-TFKCND----KADTSSLIINNKLICNETVE 778
+ + + +D + L+S + + +D KA L +N+++ ET
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-ETKT 361
Query: 779 VPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIR 838
+ +D + +++E E + + AK + + + D+KK EE+ +E +
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM--DRKKIEELMEENMTLE-MA 418
Query: 839 VLQENNEGLRAFLLTIENELKNEKEEKAEL-NKQIVHFQQELSLS-----EKKNLTLSKE 892
Q +E L L E E + E +E K + H EL+ S E +N +L+K
Sbjct: 419 QKQSMDESLH---LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 893 VQQIQSNYDIA---IAELHVQKSKNQEQEEKIMKLSNEIETATRSITN--NVSQIKLMHT 947
V+++++ D +++ + +NQ +K+ L NEI +S+ N N+S+ LM
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSK-DLMKE 534
Query: 948 KIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEP 1007
K +T++++ + S + L E ++L T L + + E R+++
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQ-----ENEHLNQTVSSLRQRSQISA----EARVKDI 585
Query: 1008 NRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEH 1067
+EN E +K +S K +IE ++QI+K E++ YK++ R +E E+
Sbjct: 586 EKENKI----------LHESIKETSSKLSKIEFEKRQIKK---ELEHYKEKGERAEELEN 632
Query: 1068 K-----NQDDLLKEKETLIQ---QLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCY 1119
+ +++LL++K T ++ + E L+++N L+ + + + + + LT +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 1120 KAKIKEL--ETILETQKVECSHSAKLEQDILEKESIILKLERN-LKEFQEHLQDSVKNTK 1176
+ + +L E + + VE A ++ L+ E+ L+ E+ LK+ E L+ S K T+
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 1177 DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK---EELSASSARTQN 1233
L V L E +L L++ +Q E E + E + L+ EEL SS R +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 1234 LKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQE 1293
L+ + + E++ + L++ +K+ K+++++ + + +KI LEK+ S+E
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 1294 LDMKQRTIQQLK--EQLNNQKVEEA--------------------IQQYERACKDLNVK- 1330
+ + + + +LK E+ N + V+ A QQ + L +
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932
Query: 1331 EKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKE 1390
EKI + L +++ T + ++LE+KLE L LE +EK LE + + +N
Sbjct: 933 EKIGLNKERLLHDEQSTDDSRYKLLESKLEST--LKKSLEIKEEKIAALEARLEESTNYN 990
Query: 1391 HENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAED 1450
+ L+ EL+ ++ Y A +++ EE+M+ + E+ NK ++ E
Sbjct: 991 QQ-----------LRQELKTVKKNYEALKQRQDEERMVQSSPPISGED--NKWERESQET 1037
Query: 1451 RERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQL 1510
K ++ + ++ ++ LQ ++ AL+ QLK L + N +I L
Sbjct: 1038 TRELLKVKDRL----IEVERNNATLQAEKQ-------ALKTQLKQLETQNNNLQAQILAL 1086
Query: 1511 KRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVST 1570
+R +T ++ Q ++ + KLQ E + + + + ++ +++ +
Sbjct: 1087 QR---QTVSLQEQNTTLQTQNA------KLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1137
Query: 1571 ENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCEN 1630
EN+ + + +L+ + L + K+ +R+++E E + K
Sbjct: 1138 ENESVIK-EREDLKSLYDSLIKDH-------------EKLELLHERQASEYESLISKHGT 1183
Query: 1631 KKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKE-GT 1689
K+A ++ +DR + + K QK + K + + + N T E
Sbjct: 1184 LKSAHKNLEVEHRDLEDRYNQLLK-QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1242
Query: 1690 LQKFGDFLQHSPS-------ILQSKAKKIIETMSSSKLSNVEASKE 1728
L D L H+ S +LQ+ K + +++SKL E
Sbjct: 1243 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE 1288
Score = 109 bits (272), Expect = 3e-23
Identities = 222/1046 (21%), Positives = 450/1046 (43%), Gaps = 168/1046 (16%)
Query: 366 EMSRVIRVSELSLCDLAG---------SERTMKTQNEGERLRET-GNINTSLLTL-GKCI 414
E+ ++ R SELS S R +K + E + L +T + T++ ++ G
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 415 NVLK-NSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFS 473
+LK E + + V E+++ QS N + N+S+ +++K
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ-------NLSK---------DLMKEK 535
Query: 474 AIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDE 533
A +K +TL + E+ +K + + N L +R+ IS E ++D+ ++
Sbjct: 536 AQLEKTI--ETLRENSER---QIKILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKEN 589
Query: 534 DLVEELENAEETQNVETKLLDE--DLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEK 591
++ E + +ET + +K+ E + K LE K EK + E+L+ +L + +
Sbjct: 590 KILHE--SIKETSSKLSKIEFEKRQIKKELEHYK------EKG---ERAEELENELHHLE 638
Query: 592 KEKLTLEFKIRE-EVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCD 650
KE L+ KI ++T E + Q ++ ERE ++ L FK+L + +
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSEL------ERE--NRKLKKTLDSFKNLTFQLE 690
Query: 651 TREEAAKDICATKVETE---EATACLELKFNQIKAELAKTKGELIKTKEELKKREN---E 704
+ E+ + +E E+ C +K Q++ E EL KE+LKK
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE----NKELESEKEQLKKGLELLKA 746
Query: 705 SDSLIQELETSNKKIITQNQRIKELINIIDQKEDTI-NEFQNLKSHMENTFKCNDKADTS 763
S + LE S + + +NQR+++ + ++K + +E Q+L+ + K ++ S
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 764 S-----LIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAIT 818
S L NK + ET ++ KD K ++ E KR+ + + + + ++ ++ + +
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKRLRQ-QAEIKDTTLEENNVKIGNLEK 864
Query: 819 EDQKKSEEVRPNIAEIEDIRVLQENNEGL--RAF-----LLTIENELKNEKEEKAELNKQ 871
E++ S+E+ ++ L++ N+ L RA L+T+ +L +EK + ++N
Sbjct: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 872 IVHFQQELS-LSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE-QEEKIMKLSNEIE 929
+ EL + K L E S Y + ++L K+ E +EEKI L +E
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984
Query: 930 TAT----------RSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEED 979
+T +++ N +K + DE R + S IS D N E +
Sbjct: 985 ESTNYNQQLRQELKTVKKNYEALK---QRQDEERMVQSSPPISGED--------NKWERE 1033
Query: 980 NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIE 1039
+ T+ +LL +VK+ I+ + + +A+ + K++ ++ QI
Sbjct: 1034 SQETTR-ELL--------KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1084
Query: 1040 ELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQI 1099
L++Q LQ + + +N +L+ ++ L + T + +L + +L+ +
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKLQV-----ENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 1100 QHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLER 1159
+ V++ + L L Y + IK+ E K+E H E+ E ES+I K
Sbjct: 1140 ESVIKEREDLKSL------YDSLIKDHE------KLELLH----ERQASEYESLISK-HG 1182
Query: 1160 NLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEK 1219
LK ++L+ ++ +D + LK K ++ L L+ + + L+ + ET E +K
Sbjct: 1183 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1242
Query: 1220 L--------------KEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKE 1265
L +E +NLK+ L + + L+ + + K+Q +Q+
Sbjct: 1243 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
Query: 1266 VSVMRDEDKLLRIKINELEKK-------------KNQCSQELDMKQRTIQQLKEQLNNQK 1312
+ + ++ +LL LE++ +N+ E +M+ + + ++++ K
Sbjct: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
Query: 1313 VEEAIQQYERACKDLNVKEKIIEDMR 1338
+ E +Q E+ ++EKI++ +
Sbjct: 1363 LNELRRQKEK------LEEKIMDQYK 1382
Score = 77.0 bits (188), Expect = 1e-13
Identities = 158/790 (20%), Positives = 329/790 (41%), Gaps = 138/790 (17%)
Query: 1056 KDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQI--QHVVEGKRALSELT 1113
K E+ R+ +K + + + L++Q+K QE L + ++ GK SE
Sbjct: 58 KLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSE-- 115
Query: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK 1173
QG ++K+L +L V+C K E+ I + + + + + + + +
Sbjct: 116 QGTE----EVKKLLLLLLGCAVQCQ---KKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE 168
Query: 1174 NTKDLNVKELK--LKEEITQLTNNLQ-DMKHLLQLKEEEEET------------------ 1212
N DL E+ +E+I L N+ +K L+ ++E ET
Sbjct: 169 NVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHAS 228
Query: 1213 -------------NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI 1259
+ + L EL+ + A+ + L+ +L+ K E D K++L + ++
Sbjct: 229 SSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL 288
Query: 1260 KQVQKE----------VSVMRDEDKLLRIKINELEKKKNQCSQ------ELDMKQRTIQQ 1303
K++Q+E + RDE LR K ++K +++ S+ +++ + +++
Sbjct: 289 KRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE 348
Query: 1304 LKE--------------QLNNQKV-EEAIQQYERACKDLNVK-----------EKIIEDM 1337
LKE QL + + + + E+ L K K IE++
Sbjct: 349 LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408
Query: 1338 ---RMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEK-----CNDLETKNNQRSNK 1389
MTLE ++ +++ L +LE++ R +EL + +K N+L + +
Sbjct: 409 MEENMTLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 1390 EHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAE 1449
E+++ T + +L D ++ + K K+ +++ + E E ++ K+ + +
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKE--NQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 1450 DRER-FFKQQNEMEILTAQLTEKDSD----LQKWREERDQLVAAL----EIQLKALISSN 1500
+ + K++ ++E L E L++ E +Q V++L +I +A + +
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARV-KD 584
Query: 1501 VQKDNEI--EQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIED 1558
++K+N+I E +K S+ SKIE + IK K + + E L + E
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIK-KELEHYKEKGERAEELENELHHLEKENEL 643
Query: 1559 GSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKS 1618
+ + +++ E ++ ELE + L+ + K+ +T ++ K S
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN------LTFQLESLEKENS 697
Query: 1619 NEMEEDL--------VKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSL 1670
EE+L +KC + K A + L+ + +KK ++ ++ S KKT
Sbjct: 698 QLDEENLELRRNVESLKCASMKMA--QLQLENKELESEKEQLKKGLEL-LKASFKKTE-- 752
Query: 1671 RSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQ------SKAKKIIETM--SSSKLSN 1722
R + S G+++ ++ + TL+ +Q S LQ +K +E + SS +L
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 1723 VEASKENVSQ 1732
+E +++ Q
Sbjct: 813 LEKENKSLEQ 822
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 145 bits (365), Expect = 4e-34
Identities = 240/1091 (21%), Positives = 470/1091 (43%), Gaps = 136/1091 (12%)
Query: 523 ENSLEDLMEDEDLVEELENAE-------ETQNVETKLLDEDLDKTLEENKAFISHEEKR- 574
E L E+++L++E AE E V ++L++ L E +A + EE R
Sbjct: 879 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938
Query: 575 --------KLLDLIEDLKKKLINEK--KEKLTLEFKIREEVTQEFTQYWAQREADFKETL 624
K+ + DL+++L E+ ++KL LE K+ E + + D L
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 625 LQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAEL 684
+ER++LEE DL EE AK++ TK++ + + EL+ K E
Sbjct: 998 SKERKLLEER-------ISDLTTNLAEEEEKAKNL--TKLKNKHESMISELEVRLKKEE- 1047
Query: 685 AKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKE--------LINIIDQK 736
K++ EL K K +L+ ++ I +L+ ++ Q + +E L + I QK
Sbjct: 1048 -KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 737 EDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNE 796
+ + + + L+ H+ +D + + + N+ + +D ++ + + + +
Sbjct: 1107 NNALKKIRELEGHI---------SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 797 ----NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLL 852
QQ+ ++ + V +++ +S E + + + ++E E L F
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 853 TIENELKNE---KEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ---SNYDIAIAE 906
N KN+ ++E A+L ++ Q E K L +VQ++Q S+ + A AE
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 907 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 966
L+ + K Q + E + + NE E + +V+ + EL + Q N+
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-LQEETRQKLNVS- 1335
Query: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENS--------FHSSIE 1018
LR L EE N QLD + + +KQ E I N + S F S++E
Sbjct: 1336 TKLRQL---EEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 1019 AIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
A+ E K K +IE L QQ E+ A + NRL+++ DDL+ + +
Sbjct: 1389 ALEEGKKRFQK-------EIENLTQQYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLD 1437
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
+QL L++K D Q + E K S+ +A+ +E ET S
Sbjct: 1438 NQ-RQLVSNLEKKQRKFD---QLLAEEKNISSKYADERDRAEAEAREKET------KALS 1487
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ LE+ + KE +LER K + ++D V + D+ +L++ L +++
Sbjct: 1488 LARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 1199 MKHLLQLKEEEEETNRQETEKLKEELSASSARTQ---NLKADLQRKEEDYADLKEKLTDA 1255
MK QL+E E+E E KL+ E++ + + Q +L+A ++ EE L+ +L +
Sbjct: 1544 MK--TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315
+ +++ +K+ ++ K L + +LE Q + ++ I+QL+ K++
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLR------KLQA 1652
Query: 1316 AIQQYERACKDLNVKEKIIEDMRMTLEEQEQ--TQVEQDQV-LEAKLEEVERLATELEKW 1372
++ ++R +D +++ T +E E+ +E D + L+ L ER + +
Sbjct: 1653 QMKDFQRELEDARASR---DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 1373 KEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQ 1432
KE+ + + N + + ++ L++EL+E + A + +++ TQ
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-----MSDRVRKATQ 1764
Query: 1433 AKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW----REERDQLVAA 1488
+AE + N + A +R K ++ + L Q E S L + + + +AA
Sbjct: 1765 --QAEQLSN----ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1489 LEIQLKALISSNVQKDNEIE-QLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLST 1547
LE ++ L Q+ E + K + + K++ ++ ++ +R A+ K Q E +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKGNA 1877
Query: 1548 SFEISRNKIED 1558
+ + ++E+
Sbjct: 1878 RVKQLKRQLEE 1888
Score = 137 bits (344), Expect = 1e-31
Identities = 234/1176 (19%), Positives = 472/1176 (40%), Gaps = 207/1176 (17%)
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
L+ + + E+ + EL KTKE +K ENE ++ELE + ++ + ++E +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQEQLQA-- 898
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRV 794
E + E + K I++ +E +D ++ +ERK++
Sbjct: 899 -------ETELYAEAEEMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKM 948
Query: 795 NENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTI 854
+ L E+Q + EE ++E + + + L +L +
Sbjct: 949 AQQMLD-----------------LEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVM 990
Query: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
+++ +E+ L ++I L+ E+K +K + ++++ ++ I+EL V+ K
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMISELEVRLKKE 1046
Query: 915 QEQEEKIMKLSNEIE-------TATRSITNNVSQIKLMHTKIDE-----LRTLDSVSQIS 962
++ +++ KL ++E + ++++K+ K +E L LD
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 963 NIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWE 1022
N L +R+L E ++ + Q DL +K K+ R +EA+
Sbjct: 1107 NNALKKIREL-----EGHISDLQEDLDSERAARNKAEKQKR--------DLGEELEALKT 1153
Query: 1023 ECKEIVKASSKKSHQIEELEQQI----EKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
E ++ + +++ + + EQ++ + L E + ++ + +++K + ++L ++ E
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
++ K L + TL+ + + R L + Q V + K K+LE ++ + +CS
Sbjct: 1214 QF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV---EHKKKKLEAQVQELQSKCS 1269
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ ++ +K + + Q ++ + K +KL +++ L++ LQD
Sbjct: 1270 DGERARAELNDK----------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 1199 MKHLLQ------------LKEEEEETNRQETEKLKEELSASSARTQNLK------ADLQR 1240
+ LLQ L++ EEE N + ++L EE+ A +++ +D ++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 1241 KEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD----- 1295
K +D+A E L + KK+ QKE+ + + + ++LEK KN+ QELD
Sbjct: 1379 KLQDFASTVEALEEGKKRF---QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 1296 ------------MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE 1343
KQR QL + N + A + +RA + KE + LEE
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALSLARALEE 1494
Query: 1344 QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTN 1403
+ + E ++ + E+E L + + + ++LE + E T +L
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT----QLEE 1550
Query: 1404 LQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEI 1463
L+DELQ +E D K LE M QA + + R+ + + + +R
Sbjct: 1551 LEDELQATE-----DAKLRLEVNM----QALKGQFERDLQARDEQNEEKR--------RQ 1593
Query: 1464 LTAQLTEKDSDLQKWREERDQLVAA---LEIQLKALISSNVQKDNEIEQLKRIISETSKI 1520
L QL E +++L+ R++R AA LE LK L +Q D+ I+ + I + K+
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---ELQADSAIKGREEAIKQLRKL 1650
Query: 1521 ETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSC-EVSTENDQSTRFP 1579
+ Q+ D + ++ED D + EN++ +
Sbjct: 1651 QAQMKDF-------------------------QRELEDARASRDEIFATAKENEKKAK-- 1683
Query: 1580 KPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKR---KSNEMEEDLVKCENKKNATP 1636
LE LQ + A + +ARK+ + E+ E+L + +NA
Sbjct: 1684 --SLEADLMQLQEDLAAAE-------------RARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 1637 RTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKK---------- 1686
+ + +E++ + S + QA + LAT++
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 1687 --EGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSE 1744
E ++ L ++SK K I + +K++ +E E ++ K+A K +
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAAL-EAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 1745 ISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
+I QV + ++ Q K R K K
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Score = 137 bits (344), Expect = 1e-31
Identities = 203/1070 (18%), Positives = 442/1070 (41%), Gaps = 151/1070 (14%)
Query: 557 LDKTLEENKAFISHEEKRKLLDLIEDLKKKL--INEKKEKLTLEFKIREEVTQEFTQYWA 614
L T +E + +E +K + + + +L + +K +LT E + +E Q T+ +A
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 615 QREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLE 674
+ E + + L +++ LEE I ++ + + E+ + + A + + + LE
Sbjct: 905 EAE-EMRVRLAAKKQELEE-------ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
+ + +A K + E + + ++KK E+E + + +K+ +RI +L +
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSER-KR 793
++E+ LK+ E+ +I V + K+ KS+ E+ KR
Sbjct: 1017 EEEEKAKNLTKLKNKHES------------------MISELEVRLKKEEKSRQELEKLKR 1058
Query: 794 VNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENN--EGLRAFL 851
E + ++ + KK EE++ +A ++D + Q+NN + +R
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRELE 1117
Query: 852 LTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQK 911
I + ++ E+A NK +EK+ L +E++ +++ + + Q+
Sbjct: 1118 GHISDLQEDLDSERAARNK-----------AEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 912 SKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRD 971
++E+++ L ++ TRS V +++ H + E T ++
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAK 1219
Query: 972 LSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKAS 1031
+ + L DL G + V Q K+ + +++ + ++ + +C + +A
Sbjct: 1220 ANLDKNKQTLEKENADLAG-ELRVLGQAKQ---EVEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 1032 SKKSHQIEELEQQIEKL-----QAEVKGYK-------------------DENNRLKEKEH 1067
++ + ++ +L+ ++E + +AE K K E R K
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 1068 KNQDDLLKEKETLIQQLKEELQEKN------VTLDVQIQHVVEGKRALSELTQGVTCY-- 1119
L +E+ +L QL EE++ K TL++Q+ + K+ L + V
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS---DSKKKLQDFASTVEALEE 1392
Query: 1120 --KAKIKELETILETQKVECSHSAKLEQ--------------DILEKESIILKLERNLKE 1163
K KE+E + + + + + KLE+ D+ + ++ LE+ ++
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452
Query: 1164 FQEHLQD----SVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEK 1219
F + L + S K + + E + +E+ T+ + + ++ L+ KEE E TN+
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM---- 1508
Query: 1220 LKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIK 1279
LK E+ + ++ ++ E+ L+ ++ + K Q+++++ E+ ED LR++
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLE 1566
Query: 1280 INELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRM 1339
+N ++ K Q ++L + ++ + QL Q + +YE +D + + +
Sbjct: 1567 VN-MQALKGQFERDLQARDEQNEEKRRQLQRQ-----LHEYETELEDERKQRALAAAAKK 1620
Query: 1340 TLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN-----KEHEN 1393
LE + + +++ D ++ + E +++L + K+ +LE R KE+E
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 1394 NTDVL-GKLTNLQDELQESEQ-KYNAD----------------RKKWLEEKMMLITQAKE 1435
L L LQ++L +E+ + AD R +EK L + +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 1436 AENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKA 1495
E +E +R K + E L+ +L + S QK R Q LE Q K
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ----LERQNKE 1796
Query: 1496 LISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPL 1545
L S + + ++ + S + +E +I ++ + A + T+ L
Sbjct: 1797 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Score = 137 bits (344), Expect = 1e-31
Identities = 207/992 (20%), Positives = 425/992 (42%), Gaps = 149/992 (15%)
Query: 530 MEDEDLVEELENAEETQNVETKLLDE---DLDKTL--EENKAFISHEEKRKLLDLIEDLK 584
+EDE LV + +N + ++ E KLL+E DL L EE KA + K K +I +L+
Sbjct: 983 LEDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 585 KKLINEKKEKLTLEFKIREEVTQEFTQYWAQ------READFKETLLQEREILE------ 632
+L E+K + LE K++ ++ + + + Q + A+ K L ++ E L+
Sbjct: 1041 VRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 633 --ENAERRLAIFK--DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTK 688
E A++ A+ K +L G +E A + + E+ L + +K EL T
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159
Query: 689 GELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL-INIIDQKEDTINEFQNLK 747
+E KRE E L + L+ + Q Q +++ +++ + + +F+ K
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 748 SHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI----------CSERKRVN-- 795
++++ + +K + + + + + + K K+ CS+ +R
Sbjct: 1220 ANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 796 --------ENELQQ-----DEPPAK-----KGSIHVSSAITEDQKK-SEEVRPNIAEIED 836
+NE++ +E K K +SS + + Q+ EE R +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 837 IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK----------- 885
+R L+E L +++L E E K L + I +LS S+KK
Sbjct: 1338 LRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 886 ---NLTLSKEVQQIQSNYDI-AIAELHVQKSKN---QEQEEKIMKLSNEIETATRSITNN 938
KE++ + Y+ A A ++K+KN QE ++ ++ L N+ +
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL-------- 1442
Query: 939 VSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQ 998
VS ++ K D+L +++ NI + E T+ L + +
Sbjct: 1443 VSNLEKKQRKFDQL-----LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 999 VKEYRIQEPNRE-----NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVK 1053
KE ++ N+ SS + + + E+ K+ Q+EE++ Q+E+L+ E++
Sbjct: 1498 AKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 1054 GYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT 1113
+D RL+ N L + E +Q E+ +EK L Q+ E + L +
Sbjct: 1557 ATEDAKLRLEV----NMQALKGQFERDLQARDEQNEEKRRQLQRQLH---EYETELEDER 1609
Query: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK 1173
+ A K+LE L+ +++ + K ++ +++ + KL+ +K+FQ L+D+
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ---LRKLQAQMKDFQRELEDARA 1666
Query: 1174 NTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS------ 1227
+ ++ + +++ L +L ++ L E + E E+L EEL++S
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726
Query: 1228 --------SARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD-------- 1271
AR L+ +L+ ++ + + +++ A +Q +Q+ E++ R
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 1272 ------EDKLLRIKINELE-KKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERAC 1324
++K LR K++E+E K++ + + I QL+EQ VE+ ++ + A
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-----VEQEAREKQAAT 1841
Query: 1325 KDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNN 1384
K L K+K ++++ + +E++ + + + E V++L +LE+ +E+ +
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 1385 --QRSNKEHENNTDVLGKLTN-LQDELQESEQ 1413
QR E + + +G+ N L+ +L+ +
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 47.4 bits (111), Expect = 1e-04
Identities = 82/394 (20%), Positives = 171/394 (43%), Gaps = 58/394 (14%)
Query: 1427 MMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLV 1486
++ +T+ +E + E++K E +++ + E+E +QLTE+ + LQ+ + +L
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 1487 AALEIQLKALISSNVQKDNEI------------EQLKRIISETSKIETQIMDIKPK-RIS 1533
A E +++ +++ Q+ EI ++ +++ +E K+ Q++D++ +
Sbjct: 904 AEAE-EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 1534 SADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPE--LEIQFTPLQ 1591
A KLQ E ++ +I K+ED +V+D DQ+ + K LE + + L
Sbjct: 963 EAARQKLQLEKVTAEAKIK--KLEDEILVMD--------DQNNKLSKERKLLEERISDLT 1012
Query: 1592 PN------------KMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTN 1639
N K+ KH + + V++ K K + ++L K + K ++
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-----QELEKLKRKLEG-DASD 1066
Query: 1640 LKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKK---KEGTLQKFGDF 1696
I+D + + + ++A + + R I N A KK EG + +
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 1697 LQHSPSILQSKAKK----IIETMSSSKLSNVEASKENVSQPK-RAKRKLYTSEISSPID- 1750
L S ++KA+K + E + + K + +Q + RAKR+ + + +D
Sbjct: 1127 LD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 1751 ----ISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
QV M QK ++ ++ ++ + K AK
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 145 bits (365), Expect = 4e-34
Identities = 240/1091 (21%), Positives = 470/1091 (43%), Gaps = 136/1091 (12%)
Query: 523 ENSLEDLMEDEDLVEELENAE-------ETQNVETKLLDEDLDKTLEENKAFISHEEKR- 574
E L E+++L++E AE E V ++L++ L E +A + EE R
Sbjct: 886 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945
Query: 575 --------KLLDLIEDLKKKLINEK--KEKLTLEFKIREEVTQEFTQYWAQREADFKETL 624
K+ + DL+++L E+ ++KL LE K+ E + + D L
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 625 LQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAEL 684
+ER++LEE DL EE AK++ TK++ + + EL+ K E
Sbjct: 1005 SKERKLLEER-------ISDLTTNLAEEEEKAKNL--TKLKNKHESMISELEVRLKKEE- 1054
Query: 685 AKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKE--------LINIIDQK 736
K++ EL K K +L+ ++ I +L+ ++ Q + +E L + I QK
Sbjct: 1055 -KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 737 EDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNE 796
+ + + + L+ H+ +D + + + N+ + +D ++ + + + +
Sbjct: 1114 NNALKKIRELEGHI---------SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 797 ----NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLL 852
QQ+ ++ + V +++ +S E + + + ++E E L F
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 853 TIENELKNE---KEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ---SNYDIAIAE 906
N KN+ ++E A+L ++ Q E K L +VQ++Q S+ + A AE
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 907 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 966
L+ + K Q + E + + NE E + +V+ + EL + Q N+
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-LQEETRQKLNVS- 1342
Query: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENS--------FHSSIE 1018
LR L EE N QLD + + +KQ E I N + S F S++E
Sbjct: 1343 TKLRQL---EEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 1019 AIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
A+ E K K +IE L QQ E+ A + NRL+++ DDL+ + +
Sbjct: 1396 ALEEGKKRFQK-------EIENLTQQYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLD 1444
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
+QL L++K D Q + E K S+ +A+ +E ET S
Sbjct: 1445 NQ-RQLVSNLEKKQRKFD---QLLAEEKNISSKYADERDRAEAEAREKET------KALS 1494
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ LE+ + KE +LER K + ++D V + D+ +L++ L +++
Sbjct: 1495 LARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 1199 MKHLLQLKEEEEETNRQETEKLKEELSASSARTQ---NLKADLQRKEEDYADLKEKLTDA 1255
MK QL+E E+E E KL+ E++ + + Q +L+A ++ EE L+ +L +
Sbjct: 1551 MK--TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315
+ +++ +K+ ++ K L + +LE Q + ++ I+QL+ K++
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLR------KLQA 1659
Query: 1316 AIQQYERACKDLNVKEKIIEDMRMTLEEQEQ--TQVEQDQV-LEAKLEEVERLATELEKW 1372
++ ++R +D +++ T +E E+ +E D + L+ L ER + +
Sbjct: 1660 QMKDFQRELEDARASR---DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 1373 KEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQ 1432
KE+ + + N + + ++ L++EL+E + A + +++ TQ
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-----MSDRVRKATQ 1771
Query: 1433 AKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW----REERDQLVAA 1488
+AE + N + A +R K ++ + L Q E S L + + + +AA
Sbjct: 1772 --QAEQLSN----ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1489 LEIQLKALISSNVQKDNEIE-QLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLST 1547
LE ++ L Q+ E + K + + K++ ++ ++ +R A+ K Q E +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKGNA 1884
Query: 1548 SFEISRNKIED 1558
+ + ++E+
Sbjct: 1885 RVKQLKRQLEE 1895
Score = 137 bits (344), Expect = 1e-31
Identities = 234/1176 (19%), Positives = 472/1176 (40%), Gaps = 207/1176 (17%)
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
L+ + + E+ + EL KTKE +K ENE ++ELE + ++ + ++E +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQEQLQA-- 905
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRV 794
E + E + K I++ +E +D ++ +ERK++
Sbjct: 906 -------ETELYAEAEEMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKM 955
Query: 795 NENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTI 854
+ L E+Q + EE ++E + + + L +L +
Sbjct: 956 AQQMLD-----------------LEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVM 997
Query: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
+++ +E+ L ++I L+ E+K +K + ++++ ++ I+EL V+ K
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMISELEVRLKKE 1053
Query: 915 QEQEEKIMKLSNEIE-------TATRSITNNVSQIKLMHTKIDE-----LRTLDSVSQIS 962
++ +++ KL ++E + ++++K+ K +E L LD
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 963 NIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWE 1022
N L +R+L E ++ + Q DL +K K+ R +EA+
Sbjct: 1114 NNALKKIREL-----EGHISDLQEDLDSERAARNKAEKQKR--------DLGEELEALKT 1160
Query: 1023 ECKEIVKASSKKSHQIEELEQQI----EKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
E ++ + +++ + + EQ++ + L E + ++ + +++K + ++L ++ E
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
++ K L + TL+ + + R L + Q V + K K+LE ++ + +CS
Sbjct: 1221 QF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV---EHKKKKLEAQVQELQSKCS 1276
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ ++ +K + + Q ++ + K +KL +++ L++ LQD
Sbjct: 1277 DGERARAELNDK----------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 1199 MKHLLQ------------LKEEEEETNRQETEKLKEELSASSARTQNLK------ADLQR 1240
+ LLQ L++ EEE N + ++L EE+ A +++ +D ++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 1241 KEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD----- 1295
K +D+A E L + KK+ QKE+ + + + ++LEK KN+ QELD
Sbjct: 1386 KLQDFASTVEALEEGKKRF---QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 1296 ------------MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE 1343
KQR QL + N + A + +RA + KE + LEE
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALSLARALEE 1501
Query: 1344 QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTN 1403
+ + E ++ + E+E L + + + ++LE + E T +L
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT----QLEE 1557
Query: 1404 LQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEI 1463
L+DELQ +E D K LE M QA + + R+ + + + +R
Sbjct: 1558 LEDELQATE-----DAKLRLEVNM----QALKGQFERDLQARDEQNEEKR--------RQ 1600
Query: 1464 LTAQLTEKDSDLQKWREERDQLVAA---LEIQLKALISSNVQKDNEIEQLKRIISETSKI 1520
L QL E +++L+ R++R AA LE LK L +Q D+ I+ + I + K+
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---ELQADSAIKGREEAIKQLRKL 1657
Query: 1521 ETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSC-EVSTENDQSTRFP 1579
+ Q+ D + ++ED D + EN++ +
Sbjct: 1658 QAQMKDF-------------------------QRELEDARASRDEIFATAKENEKKAK-- 1690
Query: 1580 KPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKR---KSNEMEEDLVKCENKKNATP 1636
LE LQ + A + +ARK+ + E+ E+L + +NA
Sbjct: 1691 --SLEADLMQLQEDLAAAE-------------RARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 1637 RTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKK---------- 1686
+ + +E++ + S + QA + LAT++
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 1687 --EGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSE 1744
E ++ L ++SK K I + +K++ +E E ++ K+A K +
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAAL-EAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 1745 ISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
+I QV + ++ Q K R K K
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Score = 137 bits (344), Expect = 1e-31
Identities = 203/1070 (18%), Positives = 442/1070 (41%), Gaps = 151/1070 (14%)
Query: 557 LDKTLEENKAFISHEEKRKLLDLIEDLKKKL--INEKKEKLTLEFKIREEVTQEFTQYWA 614
L T +E + +E +K + + + +L + +K +LT E + +E Q T+ +A
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 615 QREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLE 674
+ E + + L +++ LEE I ++ + + E+ + + A + + + LE
Sbjct: 912 EAE-EMRVRLAAKKQELEE-------ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
+ + +A K + E + + ++KK E+E + + +K+ +RI +L +
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSER-KR 793
++E+ LK+ E+ +I V + K+ KS+ E+ KR
Sbjct: 1024 EEEEKAKNLTKLKNKHES------------------MISELEVRLKKEEKSRQELEKLKR 1065
Query: 794 VNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENN--EGLRAFL 851
E + ++ + KK EE++ +A ++D + Q+NN + +R
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRELE 1124
Query: 852 LTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQK 911
I + ++ E+A NK +EK+ L +E++ +++ + + Q+
Sbjct: 1125 GHISDLQEDLDSERAARNK-----------AEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 912 SKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRD 971
++E+++ L ++ TRS V +++ H + E T ++
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAK 1226
Query: 972 LSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKAS 1031
+ + L DL G + V Q K+ + +++ + ++ + +C + +A
Sbjct: 1227 ANLDKNKQTLEKENADLAG-ELRVLGQAKQ---EVEHKKKKLEAQVQELQSKCSDGERAR 1282
Query: 1032 SKKSHQIEELEQQIEKL-----QAEVKGYK-------------------DENNRLKEKEH 1067
++ + ++ +L+ ++E + +AE K K E R K
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 1068 KNQDDLLKEKETLIQQLKEELQEKN------VTLDVQIQHVVEGKRALSELTQGVTCY-- 1119
L +E+ +L QL EE++ K TL++Q+ + K+ L + V
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS---DSKKKLQDFASTVEALEE 1399
Query: 1120 --KAKIKELETILETQKVECSHSAKLEQ--------------DILEKESIILKLERNLKE 1163
K KE+E + + + + + KLE+ D+ + ++ LE+ ++
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459
Query: 1164 FQEHLQD----SVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEK 1219
F + L + S K + + E + +E+ T+ + + ++ L+ KEE E TN+
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM---- 1515
Query: 1220 LKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIK 1279
LK E+ + ++ ++ E+ L+ ++ + K Q+++++ E+ ED LR++
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLE 1573
Query: 1280 INELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRM 1339
+N ++ K Q ++L + ++ + QL Q + +YE +D + + +
Sbjct: 1574 VN-MQALKGQFERDLQARDEQNEEKRRQLQRQ-----LHEYETELEDERKQRALAAAAKK 1627
Query: 1340 TLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN-----KEHEN 1393
LE + + +++ D ++ + E +++L + K+ +LE R KE+E
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 1394 NTDVL-GKLTNLQDELQESEQ-KYNAD----------------RKKWLEEKMMLITQAKE 1435
L L LQ++L +E+ + AD R +EK L + +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 1436 AENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKA 1495
E +E +R K + E L+ +L + S QK R Q LE Q K
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ----LERQNKE 1803
Query: 1496 LISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPL 1545
L S + + ++ + S + +E +I ++ + A + T+ L
Sbjct: 1804 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Score = 137 bits (344), Expect = 1e-31
Identities = 207/992 (20%), Positives = 425/992 (42%), Gaps = 149/992 (15%)
Query: 530 MEDEDLVEELENAEETQNVETKLLDE---DLDKTL--EENKAFISHEEKRKLLDLIEDLK 584
+EDE LV + +N + ++ E KLL+E DL L EE KA + K K +I +L+
Sbjct: 990 LEDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 585 KKLINEKKEKLTLEFKIREEVTQEFTQYWAQ------READFKETLLQEREILE------ 632
+L E+K + LE K++ ++ + + + Q + A+ K L ++ E L+
Sbjct: 1048 VRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 633 --ENAERRLAIFK--DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTK 688
E A++ A+ K +L G +E A + + E+ L + +K EL T
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166
Query: 689 GELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL-INIIDQKEDTINEFQNLK 747
+E KRE E L + L+ + Q Q +++ +++ + + +F+ K
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 748 SHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI----------CSERKRVN-- 795
++++ + +K + + + + + + K K+ CS+ +R
Sbjct: 1227 ANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 796 --------ENELQQ-----DEPPAK-----KGSIHVSSAITEDQKK-SEEVRPNIAEIED 836
+NE++ +E K K +SS + + Q+ EE R +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 837 IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK----------- 885
+R L+E L +++L E E K L + I +LS S+KK
Sbjct: 1345 LRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 886 ---NLTLSKEVQQIQSNYDI-AIAELHVQKSKN---QEQEEKIMKLSNEIETATRSITNN 938
KE++ + Y+ A A ++K+KN QE ++ ++ L N+ +
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL-------- 1449
Query: 939 VSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQ 998
VS ++ K D+L +++ NI + E T+ L + +
Sbjct: 1450 VSNLEKKQRKFDQL-----LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 999 VKEYRIQEPNRE-----NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVK 1053
KE ++ N+ SS + + + E+ K+ Q+EE++ Q+E+L+ E++
Sbjct: 1505 AKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 1054 GYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT 1113
+D RL+ N L + E +Q E+ +EK L Q+ E + L +
Sbjct: 1564 ATEDAKLRLEV----NMQALKGQFERDLQARDEQNEEKRRQLQRQLH---EYETELEDER 1616
Query: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK 1173
+ A K+LE L+ +++ + K ++ +++ + KL+ +K+FQ L+D+
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ---LRKLQAQMKDFQRELEDARA 1673
Query: 1174 NTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS------ 1227
+ ++ + +++ L +L ++ L E + E E+L EEL++S
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733
Query: 1228 --------SARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD-------- 1271
AR L+ +L+ ++ + + +++ A +Q +Q+ E++ R
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 1272 ------EDKLLRIKINELE-KKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERAC 1324
++K LR K++E+E K++ + + I QL+EQ VE+ ++ + A
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-----VEQEAREKQAAT 1848
Query: 1325 KDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNN 1384
K L K+K ++++ + +E++ + + + E V++L +LE+ +E+ +
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 1385 --QRSNKEHENNTDVLGKLTN-LQDELQESEQ 1413
QR E + + +G+ N L+ +L+ +
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 47.4 bits (111), Expect = 1e-04
Identities = 82/394 (20%), Positives = 171/394 (43%), Gaps = 58/394 (14%)
Query: 1427 MMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLV 1486
++ +T+ +E + E++K E +++ + E+E +QLTE+ + LQ+ + +L
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 1487 AALEIQLKALISSNVQKDNEI------------EQLKRIISETSKIETQIMDIKPK-RIS 1533
A E +++ +++ Q+ EI ++ +++ +E K+ Q++D++ +
Sbjct: 911 AEAE-EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 1534 SADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPE--LEIQFTPLQ 1591
A KLQ E ++ +I K+ED +V+D DQ+ + K LE + + L
Sbjct: 970 EAARQKLQLEKVTAEAKIK--KLEDEILVMD--------DQNNKLSKERKLLEERISDLT 1019
Query: 1592 PN------------KMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTN 1639
N K+ KH + + V++ K K + ++L K + K ++
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-----QELEKLKRKLEG-DASD 1073
Query: 1640 LKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKK---KEGTLQKFGDF 1696
I+D + + + ++A + + R I N A KK EG + +
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 1697 LQHSPSILQSKAKK----IIETMSSSKLSNVEASKENVSQPK-RAKRKLYTSEISSPID- 1750
L S ++KA+K + E + + K + +Q + RAKR+ + + +D
Sbjct: 1134 LD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 1751 ----ISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
QV M QK ++ ++ ++ + K AK
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 145 bits (365), Expect = 4e-34
Identities = 240/1091 (21%), Positives = 470/1091 (43%), Gaps = 136/1091 (12%)
Query: 523 ENSLEDLMEDEDLVEELENAE-------ETQNVETKLLDEDLDKTLEENKAFISHEEKR- 574
E L E+++L++E AE E V ++L++ L E +A + EE R
Sbjct: 886 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945
Query: 575 --------KLLDLIEDLKKKLINEK--KEKLTLEFKIREEVTQEFTQYWAQREADFKETL 624
K+ + DL+++L E+ ++KL LE K+ E + + D L
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 625 LQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAEL 684
+ER++LEE DL EE AK++ TK++ + + EL+ K E
Sbjct: 1005 SKERKLLEER-------ISDLTTNLAEEEEKAKNL--TKLKNKHESMISELEVRLKKEE- 1054
Query: 685 AKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKE--------LINIIDQK 736
K++ EL K K +L+ ++ I +L+ ++ Q + +E L + I QK
Sbjct: 1055 -KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 737 EDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNE 796
+ + + + L+ H+ +D + + + N+ + +D ++ + + + +
Sbjct: 1114 NNALKKIRELEGHI---------SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 797 ----NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLL 852
QQ+ ++ + V +++ +S E + + + ++E E L F
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 853 TIENELKNE---KEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ---SNYDIAIAE 906
N KN+ ++E A+L ++ Q E K L +VQ++Q S+ + A AE
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 907 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 966
L+ + K Q + E + + NE E + +V+ + EL + Q N+
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-LQEETRQKLNVS- 1342
Query: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENS--------FHSSIE 1018
LR L EE N QLD + + +KQ E I N + S F S++E
Sbjct: 1343 TKLRQL---EEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 1019 AIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
A+ E K K +IE L QQ E+ A + NRL+++ DDL+ + +
Sbjct: 1396 ALEEGKKRFQK-------EIENLTQQYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLD 1444
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
+QL L++K D Q + E K S+ +A+ +E ET S
Sbjct: 1445 NQ-RQLVSNLEKKQRKFD---QLLAEEKNISSKYADERDRAEAEAREKET------KALS 1494
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ LE+ + KE +LER K + ++D V + D+ +L++ L +++
Sbjct: 1495 LARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 1199 MKHLLQLKEEEEETNRQETEKLKEELSASSARTQ---NLKADLQRKEEDYADLKEKLTDA 1255
MK QL+E E+E E KL+ E++ + + Q +L+A ++ EE L+ +L +
Sbjct: 1551 MK--TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315
+ +++ +K+ ++ K L + +LE Q + ++ I+QL+ K++
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLR------KLQA 1659
Query: 1316 AIQQYERACKDLNVKEKIIEDMRMTLEEQEQ--TQVEQDQV-LEAKLEEVERLATELEKW 1372
++ ++R +D +++ T +E E+ +E D + L+ L ER + +
Sbjct: 1660 QMKDFQRELEDARASR---DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 1373 KEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQ 1432
KE+ + + N + + ++ L++EL+E + A + +++ TQ
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-----MSDRVRKATQ 1771
Query: 1433 AKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW----REERDQLVAA 1488
+AE + N + A +R K ++ + L Q E S L + + + +AA
Sbjct: 1772 --QAEQLSN----ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1489 LEIQLKALISSNVQKDNEIE-QLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLST 1547
LE ++ L Q+ E + K + + K++ ++ ++ +R A+ K Q E +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKGNA 1884
Query: 1548 SFEISRNKIED 1558
+ + ++E+
Sbjct: 1885 RVKQLKRQLEE 1895
Score = 137 bits (344), Expect = 1e-31
Identities = 234/1176 (19%), Positives = 472/1176 (40%), Gaps = 207/1176 (17%)
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
L+ + + E+ + EL KTKE +K ENE ++ELE + ++ + ++E +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQEQLQA-- 905
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRV 794
E + E + K I++ +E +D ++ +ERK++
Sbjct: 906 -------ETELYAEAEEMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKM 955
Query: 795 NENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTI 854
+ L E+Q + EE ++E + + + L +L +
Sbjct: 956 AQQMLD-----------------LEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVM 997
Query: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
+++ +E+ L ++I L+ E+K +K + ++++ ++ I+EL V+ K
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMISELEVRLKKE 1053
Query: 915 QEQEEKIMKLSNEIE-------TATRSITNNVSQIKLMHTKIDE-----LRTLDSVSQIS 962
++ +++ KL ++E + ++++K+ K +E L LD
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 963 NIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWE 1022
N L +R+L E ++ + Q DL +K K+ R +EA+
Sbjct: 1114 NNALKKIREL-----EGHISDLQEDLDSERAARNKAEKQKR--------DLGEELEALKT 1160
Query: 1023 ECKEIVKASSKKSHQIEELEQQI----EKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
E ++ + +++ + + EQ++ + L E + ++ + +++K + ++L ++ E
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
++ K L + TL+ + + R L + Q V + K K+LE ++ + +CS
Sbjct: 1221 QF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV---EHKKKKLEAQVQELQSKCS 1276
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ ++ +K + + Q ++ + K +KL +++ L++ LQD
Sbjct: 1277 DGERARAELNDK----------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 1199 MKHLLQ------------LKEEEEETNRQETEKLKEELSASSARTQNLK------ADLQR 1240
+ LLQ L++ EEE N + ++L EE+ A +++ +D ++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 1241 KEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD----- 1295
K +D+A E L + KK+ QKE+ + + + ++LEK KN+ QELD
Sbjct: 1386 KLQDFASTVEALEEGKKRF---QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 1296 ------------MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE 1343
KQR QL + N + A + +RA + KE + LEE
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALSLARALEE 1501
Query: 1344 QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTN 1403
+ + E ++ + E+E L + + + ++LE + E T +L
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT----QLEE 1557
Query: 1404 LQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEI 1463
L+DELQ +E D K LE M QA + + R+ + + + +R
Sbjct: 1558 LEDELQATE-----DAKLRLEVNM----QALKGQFERDLQARDEQNEEKR--------RQ 1600
Query: 1464 LTAQLTEKDSDLQKWREERDQLVAA---LEIQLKALISSNVQKDNEIEQLKRIISETSKI 1520
L QL E +++L+ R++R AA LE LK L +Q D+ I+ + I + K+
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---ELQADSAIKGREEAIKQLRKL 1657
Query: 1521 ETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSC-EVSTENDQSTRFP 1579
+ Q+ D + ++ED D + EN++ +
Sbjct: 1658 QAQMKDF-------------------------QRELEDARASRDEIFATAKENEKKAK-- 1690
Query: 1580 KPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKR---KSNEMEEDLVKCENKKNATP 1636
LE LQ + A + +ARK+ + E+ E+L + +NA
Sbjct: 1691 --SLEADLMQLQEDLAAAE-------------RARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 1637 RTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKK---------- 1686
+ + +E++ + S + QA + LAT++
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 1687 --EGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSE 1744
E ++ L ++SK K I + +K++ +E E ++ K+A K +
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAAL-EAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 1745 ISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
+I QV + ++ Q K R K K
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Score = 137 bits (344), Expect = 1e-31
Identities = 203/1070 (18%), Positives = 442/1070 (41%), Gaps = 151/1070 (14%)
Query: 557 LDKTLEENKAFISHEEKRKLLDLIEDLKKKL--INEKKEKLTLEFKIREEVTQEFTQYWA 614
L T +E + +E +K + + + +L + +K +LT E + +E Q T+ +A
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 615 QREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLE 674
+ E + + L +++ LEE I ++ + + E+ + + A + + + LE
Sbjct: 912 EAE-EMRVRLAAKKQELEE-------ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
+ + +A K + E + + ++KK E+E + + +K+ +RI +L +
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSER-KR 793
++E+ LK+ E+ +I V + K+ KS+ E+ KR
Sbjct: 1024 EEEEKAKNLTKLKNKHES------------------MISELEVRLKKEEKSRQELEKLKR 1065
Query: 794 VNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENN--EGLRAFL 851
E + ++ + KK EE++ +A ++D + Q+NN + +R
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRELE 1124
Query: 852 LTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQK 911
I + ++ E+A NK +EK+ L +E++ +++ + + Q+
Sbjct: 1125 GHISDLQEDLDSERAARNK-----------AEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 912 SKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRD 971
++E+++ L ++ TRS V +++ H + E T ++
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAK 1226
Query: 972 LSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKAS 1031
+ + L DL G + V Q K+ + +++ + ++ + +C + +A
Sbjct: 1227 ANLDKNKQTLEKENADLAG-ELRVLGQAKQ---EVEHKKKKLEAQVQELQSKCSDGERAR 1282
Query: 1032 SKKSHQIEELEQQIEKL-----QAEVKGYK-------------------DENNRLKEKEH 1067
++ + ++ +L+ ++E + +AE K K E R K
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 1068 KNQDDLLKEKETLIQQLKEELQEKN------VTLDVQIQHVVEGKRALSELTQGVTCY-- 1119
L +E+ +L QL EE++ K TL++Q+ + K+ L + V
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS---DSKKKLQDFASTVEALEE 1399
Query: 1120 --KAKIKELETILETQKVECSHSAKLEQ--------------DILEKESIILKLERNLKE 1163
K KE+E + + + + + KLE+ D+ + ++ LE+ ++
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459
Query: 1164 FQEHLQD----SVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEK 1219
F + L + S K + + E + +E+ T+ + + ++ L+ KEE E TN+
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM---- 1515
Query: 1220 LKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIK 1279
LK E+ + ++ ++ E+ L+ ++ + K Q+++++ E+ ED LR++
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLE 1573
Query: 1280 INELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRM 1339
+N ++ K Q ++L + ++ + QL Q + +YE +D + + +
Sbjct: 1574 VN-MQALKGQFERDLQARDEQNEEKRRQLQRQ-----LHEYETELEDERKQRALAAAAKK 1627
Query: 1340 TLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN-----KEHEN 1393
LE + + +++ D ++ + E +++L + K+ +LE R KE+E
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 1394 NTDVL-GKLTNLQDELQESEQ-KYNAD----------------RKKWLEEKMMLITQAKE 1435
L L LQ++L +E+ + AD R +EK L + +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 1436 AENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKA 1495
E +E +R K + E L+ +L + S QK R Q LE Q K
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ----LERQNKE 1803
Query: 1496 LISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPL 1545
L S + + ++ + S + +E +I ++ + A + T+ L
Sbjct: 1804 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Score = 136 bits (343), Expect = 2e-31
Identities = 205/981 (20%), Positives = 419/981 (42%), Gaps = 148/981 (15%)
Query: 530 MEDEDLVEELENAEETQNVETKLLDE---DLDKTL--EENKAFISHEEKRKLLDLIEDLK 584
+EDE LV + +N + ++ E KLL+E DL L EE KA + K K +I +L+
Sbjct: 990 LEDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 585 KKLINEKKEKLTLEFKIREEVTQEFTQYWAQ------READFKETLLQEREILE------ 632
+L E+K + LE K++ ++ + + + Q + A+ K L ++ E L+
Sbjct: 1048 VRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 633 --ENAERRLAIFK--DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTK 688
E A++ A+ K +L G +E A + + E+ L + +K EL T
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166
Query: 689 GELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL-INIIDQKEDTINEFQNLK 747
+E KRE E L + L+ + Q Q +++ +++ + + +F+ K
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 748 SHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI----------CSERKRVN-- 795
++++ + +K + + + + + + K K+ CS+ +R
Sbjct: 1227 ANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 796 --------ENELQQ-----DEPPAK-----KGSIHVSSAITEDQKK-SEEVRPNIAEIED 836
+NE++ +E K K +SS + + Q+ EE R +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 837 IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK----------- 885
+R L+E L +++L E E K L + I +LS S+KK
Sbjct: 1345 LRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 886 ---NLTLSKEVQQIQSNYDI-AIAELHVQKSKN---QEQEEKIMKLSNEIETATRSITNN 938
KE++ + Y+ A A ++K+KN QE ++ ++ L N+ +
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL-------- 1449
Query: 939 VSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQ 998
VS ++ K D+L +++ NI + E T+ L + +
Sbjct: 1450 VSNLEKKQRKFDQL-----LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 999 VKEYRIQEPNRE-----NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVK 1053
KE ++ N+ SS + + + E+ K+ Q+EE++ Q+E+L+ E++
Sbjct: 1505 AKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 1054 GYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT 1113
+D RL+ N L + E +Q E+ +EK L Q+ E + L +
Sbjct: 1564 ATEDAKLRLEV----NMQALKGQFERDLQARDEQNEEKRRQLQRQLH---EYETELEDER 1616
Query: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK 1173
+ A K+LE L+ +++ + K ++ +++ + KL+ +K+FQ L+D+
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ---LRKLQAQMKDFQRELEDARA 1673
Query: 1174 NTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS------ 1227
+ ++ + +++ L +L ++ L E + E E+L EEL++S
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1733
Query: 1228 --------SARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD-------- 1271
AR L+ +L+ ++ + + +++ A +Q +Q+ E++ R
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 1272 ------EDKLLRIKINELE-KKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERAC 1324
++K LR K++E+E K++ + + I QL+EQ VE+ ++ + A
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-----VEQEAREKQAAT 1848
Query: 1325 KDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNN 1384
K L K+K ++++ + +E++ + + + E V++L +LE+ +E+ +
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 1385 --QRSNKEHENNTDVLGKLTN 1403
QR E + + +G+ N
Sbjct: 1909 KLQRELDEATESNEAMGREVN 1929
Score = 97.4 bits (241), Expect = 1e-19
Identities = 178/878 (20%), Positives = 359/878 (40%), Gaps = 124/878 (14%)
Query: 476 AQKVCVPDTLNSSQEKLFGPVKSSQDVS-----LDSNSNSKILNVKRATISWENSLEDLM 530
A K + DTL+S+ + K Q+V+ LD + S V+ ++E+L
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 531 EDEDLVEE----LENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKK 586
E + + L+ ++T E L +L + L + K + H+ K+KL +++L+ K
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHK-KKKLEAQVQELQSK 1274
Query: 587 LINEKKEKLTLEFKIR------EEVTQEFTQY------WAQREADFKETLLQEREILEEN 634
+ ++ + L K+ E VT + A+ A L +E+L+E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 635 AERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGEL--- 691
++L + K EE + E EA LE + + +L+ +K +L
Sbjct: 1335 TRQKLNVST----KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 692 ---IKTKEELKKR-ENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLK 747
++ EE KKR + E ++L Q+ E +K ++ K + + +D + + N +
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 748 SHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAK 807
+ N K K D +L+ E K+ SK ER R E E ++ E A
Sbjct: 1448 QLVSNLEKKQRKFD--------QLLAEE-----KNISSKYADERDRA-EAEAREKETKAL 1493
Query: 808 KGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAE 867
+ + A+ ++ + AE+ED+ V +++ G L E + + + E
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDL-VSSKDDVGKNVHEL--EKSKRALETQMEE 1550
Query: 868 LNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNE 927
+ Q+ + EL +E L L +Q ++ ++ +L + +N+E+ ++ + +E
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHE 1607
Query: 928 IETATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQL 986
ET + K++ +L+ L+ L G EE +L
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEAIKQLRKL 1657
Query: 987 DLLGNDY---LVSKQVKEYRIQEPNRENSFHS-SIEAIWEECKEIVKASSKKSHQIE-EL 1041
D+ L + I +EN + S+EA + +E + A+ + Q + E
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 1042 EQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQH 1101
E+ E+L + + G N L++++ + E I QL+EEL+E+ ++
Sbjct: 1718 EELAEELASSLSG----RNALQDEKRR--------LEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1102 VVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNL 1161
V + + +L+ E E + + SA+ + + KE L L
Sbjct: 1766 VRKATQQAEQLSN------------ELATERSTAQKNESARQQLERQNKE-----LRSKL 1808
Query: 1162 KEFQEHLQDSVKNT-KDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKL 1220
E + ++ K+T L K +L+E++ Q K+ ++ +Q+ +KL
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE----------KQAATKSLKQKDKKL 1858
Query: 1221 KEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKI 1280
KE L L+ + +RK + KE+ ++KQ+++++ +E + +
Sbjct: 1859 KEIL---------LQVEDERKMAE--QYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 1281 NELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQ 1318
+L+++ ++ ++ + R + LK +L +E Q
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1945
Score = 47.4 bits (111), Expect = 1e-04
Identities = 82/394 (20%), Positives = 171/394 (43%), Gaps = 58/394 (14%)
Query: 1427 MMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLV 1486
++ +T+ +E + E++K E +++ + E+E +QLTE+ + LQ+ + +L
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 1487 AALEIQLKALISSNVQKDNEI------------EQLKRIISETSKIETQIMDIKPK-RIS 1533
A E +++ +++ Q+ EI ++ +++ +E K+ Q++D++ +
Sbjct: 911 AEAE-EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 1534 SADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPE--LEIQFTPLQ 1591
A KLQ E ++ +I K+ED +V+D DQ+ + K LE + + L
Sbjct: 970 EAARQKLQLEKVTAEAKIK--KLEDEILVMD--------DQNNKLSKERKLLEERISDLT 1019
Query: 1592 PN------------KMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTN 1639
N K+ KH + + V++ K K + ++L K + K ++
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-----QELEKLKRKLEG-DASD 1073
Query: 1640 LKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKK---KEGTLQKFGDF 1696
I+D + + + ++A + + R I N A KK EG + +
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 1697 LQHSPSILQSKAKK----IIETMSSSKLSNVEASKENVSQPK-RAKRKLYTSEISSPID- 1750
L S ++KA+K + E + + K + +Q + RAKR+ + + +D
Sbjct: 1134 LD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 1751 ----ISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
QV M QK ++ ++ ++ + K AK
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 145 bits (365), Expect = 4e-34
Identities = 240/1091 (21%), Positives = 470/1091 (43%), Gaps = 136/1091 (12%)
Query: 523 ENSLEDLMEDEDLVEELENAE-------ETQNVETKLLDEDLDKTLEENKAFISHEEKR- 574
E L E+++L++E AE E V ++L++ L E +A + EE R
Sbjct: 879 EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938
Query: 575 --------KLLDLIEDLKKKLINEK--KEKLTLEFKIREEVTQEFTQYWAQREADFKETL 624
K+ + DL+++L E+ ++KL LE K+ E + + D L
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 625 LQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAEL 684
+ER++LEE DL EE AK++ TK++ + + EL+ K E
Sbjct: 998 SKERKLLEER-------ISDLTTNLAEEEEKAKNL--TKLKNKHESMISELEVRLKKEE- 1047
Query: 685 AKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKE--------LINIIDQK 736
K++ EL K K +L+ ++ I +L+ ++ Q + +E L + I QK
Sbjct: 1048 -KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 737 EDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNE 796
+ + + + L+ H+ +D + + + N+ + +D ++ + + + +
Sbjct: 1107 NNALKKIRELEGHI---------SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 797 ----NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLL 852
QQ+ ++ + V +++ +S E + + + ++E E L F
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 853 TIENELKNE---KEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ---SNYDIAIAE 906
N KN+ ++E A+L ++ Q E K L +VQ++Q S+ + A AE
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 907 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 966
L+ + K Q + E + + NE E + +V+ + EL + Q N+
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-LQEETRQKLNVS- 1335
Query: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENS--------FHSSIE 1018
LR L EE N QLD + + +KQ E I N + S F S++E
Sbjct: 1336 TKLRQL---EEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 1019 AIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
A+ E K K +IE L QQ E+ A + NRL+++ DDL+ + +
Sbjct: 1389 ALEEGKKRFQK-------EIENLTQQYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLD 1437
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
+QL L++K D Q + E K S+ +A+ +E ET S
Sbjct: 1438 NQ-RQLVSNLEKKQRKFD---QLLAEEKNISSKYADERDRAEAEAREKET------KALS 1487
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ LE+ + KE +LER K + ++D V + D+ +L++ L +++
Sbjct: 1488 LARALEEALEAKE----ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 1199 MKHLLQLKEEEEETNRQETEKLKEELSASSARTQ---NLKADLQRKEEDYADLKEKLTDA 1255
MK QL+E E+E E KL+ E++ + + Q +L+A ++ EE L+ +L +
Sbjct: 1544 MK--TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315
+ +++ +K+ ++ K L + +LE Q + ++ I+QL+ K++
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLEL---QADSAIKGREEAIKQLR------KLQA 1652
Query: 1316 AIQQYERACKDLNVKEKIIEDMRMTLEEQEQ--TQVEQDQV-LEAKLEEVERLATELEKW 1372
++ ++R +D +++ T +E E+ +E D + L+ L ER + +
Sbjct: 1653 QMKDFQRELEDARASR---DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 1373 KEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQ 1432
KE+ + + N + + ++ L++EL+E + A + +++ TQ
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-----MSDRVRKATQ 1764
Query: 1433 AKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW----REERDQLVAA 1488
+AE + N + A +R K ++ + L Q E S L + + + +AA
Sbjct: 1765 --QAEQLSN----ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1489 LEIQLKALISSNVQKDNEIE-QLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLST 1547
LE ++ L Q+ E + K + + K++ ++ ++ +R A+ K Q E +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKGNA 1877
Query: 1548 SFEISRNKIED 1558
+ + ++E+
Sbjct: 1878 RVKQLKRQLEE 1888
Score = 137 bits (344), Expect = 1e-31
Identities = 234/1176 (19%), Positives = 472/1176 (40%), Gaps = 207/1176 (17%)
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
L+ + + E+ + EL KTKE +K ENE ++ELE + ++ + ++E +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENE----LKELEQKHSQLTEEKNLLQEQLQA-- 898
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRV 794
E + E + K I++ +E +D ++ +ERK++
Sbjct: 899 -------ETELYAEAEEMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKM 948
Query: 795 NENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTI 854
+ L E+Q + EE ++E + + + L +L +
Sbjct: 949 AQQMLD-----------------LEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVM 990
Query: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
+++ +E+ L ++I L+ E+K +K + ++++ ++ I+EL V+ K
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLAEEEEK----AKNLTKLKNKHESMISELEVRLKKE 1046
Query: 915 QEQEEKIMKLSNEIE-------TATRSITNNVSQIKLMHTKIDE-----LRTLDSVSQIS 962
++ +++ KL ++E + ++++K+ K +E L LD
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 963 NIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWE 1022
N L +R+L E ++ + Q DL +K K+ R +EA+
Sbjct: 1107 NNALKKIREL-----EGHISDLQEDLDSERAARNKAEKQKR--------DLGEELEALKT 1153
Query: 1023 ECKEIVKASSKKSHQIEELEQQI----EKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKE 1078
E ++ + +++ + + EQ++ + L E + ++ + +++K + ++L ++ E
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 1079 TLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECS 1138
++ K L + TL+ + + R L + Q V + K K+LE ++ + +CS
Sbjct: 1214 QF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV---EHKKKKLEAQVQELQSKCS 1269
Query: 1139 HSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD 1198
+ ++ +K + + Q ++ + K +KL +++ L++ LQD
Sbjct: 1270 DGERARAELNDK----------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 1199 MKHLLQ------------LKEEEEETNRQETEKLKEELSASSARTQNLK------ADLQR 1240
+ LLQ L++ EEE N + ++L EE+ A +++ +D ++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 1241 KEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD----- 1295
K +D+A E L + KK+ QKE+ + + + ++LEK KN+ QELD
Sbjct: 1379 KLQDFASTVEALEEGKKRF---QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 1296 ------------MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE 1343
KQR QL + N + A + +RA + KE + LEE
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALSLARALEE 1494
Query: 1344 QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTN 1403
+ + E ++ + E+E L + + + ++LE + E T +L
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT----QLEE 1550
Query: 1404 LQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEI 1463
L+DELQ +E D K LE M QA + + R+ + + + +R
Sbjct: 1551 LEDELQATE-----DAKLRLEVNM----QALKGQFERDLQARDEQNEEKR--------RQ 1593
Query: 1464 LTAQLTEKDSDLQKWREERDQLVAA---LEIQLKALISSNVQKDNEIEQLKRIISETSKI 1520
L QL E +++L+ R++R AA LE LK L +Q D+ I+ + I + K+
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---ELQADSAIKGREEAIKQLRKL 1650
Query: 1521 ETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSC-EVSTENDQSTRFP 1579
+ Q+ D + ++ED D + EN++ +
Sbjct: 1651 QAQMKDF-------------------------QRELEDARASRDEIFATAKENEKKAK-- 1683
Query: 1580 KPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKR---KSNEMEEDLVKCENKKNATP 1636
LE LQ + A + +ARK+ + E+ E+L + +NA
Sbjct: 1684 --SLEADLMQLQEDLAAAE-------------RARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 1637 RTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKK---------- 1686
+ + +E++ + S + QA + LAT++
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 1687 --EGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSE 1744
E ++ L ++SK K I + +K++ +E E ++ K+A K +
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAAL-EAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 1745 ISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
+I QV + ++ Q K R K K
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Score = 137 bits (344), Expect = 1e-31
Identities = 203/1070 (18%), Positives = 442/1070 (41%), Gaps = 151/1070 (14%)
Query: 557 LDKTLEENKAFISHEEKRKLLDLIEDLKKKL--INEKKEKLTLEFKIREEVTQEFTQYWA 614
L T +E + +E +K + + + +L + +K +LT E + +E Q T+ +A
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 615 QREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLE 674
+ E + + L +++ LEE I ++ + + E+ + + A + + + LE
Sbjct: 905 EAE-EMRVRLAAKKQELEE-------ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
+ + +A K + E + + ++KK E+E + + +K+ +RI +L +
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSER-KR 793
++E+ LK+ E+ +I V + K+ KS+ E+ KR
Sbjct: 1017 EEEEKAKNLTKLKNKHES------------------MISELEVRLKKEEKSRQELEKLKR 1058
Query: 794 VNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENN--EGLRAFL 851
E + ++ + KK EE++ +A ++D + Q+NN + +R
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRELE 1117
Query: 852 LTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQK 911
I + ++ E+A NK +EK+ L +E++ +++ + + Q+
Sbjct: 1118 GHISDLQEDLDSERAARNK-----------AEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 912 SKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRD 971
++E+++ L ++ TRS V +++ H + E T ++
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAK 1219
Query: 972 LSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKAS 1031
+ + L DL G + V Q K+ + +++ + ++ + +C + +A
Sbjct: 1220 ANLDKNKQTLEKENADLAG-ELRVLGQAKQ---EVEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 1032 SKKSHQIEELEQQIEKL-----QAEVKGYK-------------------DENNRLKEKEH 1067
++ + ++ +L+ ++E + +AE K K E R K
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 1068 KNQDDLLKEKETLIQQLKEELQEKN------VTLDVQIQHVVEGKRALSELTQGVTCY-- 1119
L +E+ +L QL EE++ K TL++Q+ + K+ L + V
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS---DSKKKLQDFASTVEALEE 1392
Query: 1120 --KAKIKELETILETQKVECSHSAKLEQ--------------DILEKESIILKLERNLKE 1163
K KE+E + + + + + KLE+ D+ + ++ LE+ ++
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452
Query: 1164 FQEHLQD----SVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEK 1219
F + L + S K + + E + +E+ T+ + + ++ L+ KEE E TN+
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM---- 1508
Query: 1220 LKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIK 1279
LK E+ + ++ ++ E+ L+ ++ + K Q+++++ E+ ED LR++
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLE 1566
Query: 1280 INELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRM 1339
+N ++ K Q ++L + ++ + QL Q + +YE +D + + +
Sbjct: 1567 VN-MQALKGQFERDLQARDEQNEEKRRQLQRQ-----LHEYETELEDERKQRALAAAAKK 1620
Query: 1340 TLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN-----KEHEN 1393
LE + + +++ D ++ + E +++L + K+ +LE R KE+E
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 1394 NTDVL-GKLTNLQDELQESEQ-KYNAD----------------RKKWLEEKMMLITQAKE 1435
L L LQ++L +E+ + AD R +EK L + +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 1436 AENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKA 1495
E +E +R K + E L+ +L + S QK R Q LE Q K
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ----LERQNKE 1796
Query: 1496 LISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPL 1545
L S + + ++ + S + +E +I ++ + A + T+ L
Sbjct: 1797 LRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Score = 136 bits (343), Expect = 2e-31
Identities = 205/981 (20%), Positives = 419/981 (42%), Gaps = 148/981 (15%)
Query: 530 MEDEDLVEELENAEETQNVETKLLDE---DLDKTL--EENKAFISHEEKRKLLDLIEDLK 584
+EDE LV + +N + ++ E KLL+E DL L EE KA + K K +I +L+
Sbjct: 983 LEDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 585 KKLINEKKEKLTLEFKIREEVTQEFTQYWAQ------READFKETLLQEREILE------ 632
+L E+K + LE K++ ++ + + + Q + A+ K L ++ E L+
Sbjct: 1041 VRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 633 --ENAERRLAIFK--DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTK 688
E A++ A+ K +L G +E A + + E+ L + +K EL T
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159
Query: 689 GELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL-INIIDQKEDTINEFQNLK 747
+E KRE E L + L+ + Q Q +++ +++ + + +F+ K
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 748 SHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI----------CSERKRVN-- 795
++++ + +K + + + + + + K K+ CS+ +R
Sbjct: 1220 ANLDKNKQTLEKENAD--LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 796 --------ENELQQ-----DEPPAK-----KGSIHVSSAITEDQKK-SEEVRPNIAEIED 836
+NE++ +E K K +SS + + Q+ EE R +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 837 IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK----------- 885
+R L+E L +++L E E K L + I +LS S+KK
Sbjct: 1338 LRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 886 ---NLTLSKEVQQIQSNYDI-AIAELHVQKSKN---QEQEEKIMKLSNEIETATRSITNN 938
KE++ + Y+ A A ++K+KN QE ++ ++ L N+ +
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL-------- 1442
Query: 939 VSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQ 998
VS ++ K D+L +++ NI + E T+ L + +
Sbjct: 1443 VSNLEKKQRKFDQL-----LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 999 VKEYRIQEPNRE-----NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVK 1053
KE ++ N+ SS + + + E+ K+ Q+EE++ Q+E+L+ E++
Sbjct: 1498 AKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 1054 GYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT 1113
+D RL+ N L + E +Q E+ +EK L Q+ E + L +
Sbjct: 1557 ATEDAKLRLEV----NMQALKGQFERDLQARDEQNEEKRRQLQRQLH---EYETELEDER 1609
Query: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK 1173
+ A K+LE L+ +++ + K ++ +++ + KL+ +K+FQ L+D+
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ---LRKLQAQMKDFQRELEDARA 1666
Query: 1174 NTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS------ 1227
+ ++ + +++ L +L ++ L E + E E+L EEL++S
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726
Query: 1228 --------SARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD-------- 1271
AR L+ +L+ ++ + + +++ A +Q +Q+ E++ R
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 1272 ------EDKLLRIKINELE-KKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERAC 1324
++K LR K++E+E K++ + + I QL+EQ VE+ ++ + A
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-----VEQEAREKQAAT 1841
Query: 1325 KDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNN 1384
K L K+K ++++ + +E++ + + + E V++L +LE+ +E+ +
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 1385 --QRSNKEHENNTDVLGKLTN 1403
QR E + + +G+ N
Sbjct: 1902 KLQRELDEATESNEAMGREVN 1922
Score = 97.4 bits (241), Expect = 1e-19
Identities = 178/878 (20%), Positives = 359/878 (40%), Gaps = 124/878 (14%)
Query: 476 AQKVCVPDTLNSSQEKLFGPVKSSQDVS-----LDSNSNSKILNVKRATISWENSLEDLM 530
A K + DTL+S+ + K Q+V+ LD + S V+ ++E+L
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 531 EDEDLVEE----LENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKK 586
E + + L+ ++T E L +L + L + K + H+ K+KL +++L+ K
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHK-KKKLEAQVQELQSK 1267
Query: 587 LINEKKEKLTLEFKIR------EEVTQEFTQY------WAQREADFKETLLQEREILEEN 634
+ ++ + L K+ E VT + A+ A L +E+L+E
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 635 AERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGEL--- 691
++L + K EE + E EA LE + + +L+ +K +L
Sbjct: 1328 TRQKLNVST----KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 692 ---IKTKEELKKR-ENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLK 747
++ EE KKR + E ++L Q+ E +K ++ K + + +D + + N +
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 748 SHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAK 807
+ N K K D +L+ E K+ SK ER R E E ++ E A
Sbjct: 1441 QLVSNLEKKQRKFD--------QLLAEE-----KNISSKYADERDRA-EAEAREKETKAL 1486
Query: 808 KGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAE 867
+ + A+ ++ + AE+ED+ V +++ G L E + + + E
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDL-VSSKDDVGKNVHEL--EKSKRALETQMEE 1543
Query: 868 LNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNE 927
+ Q+ + EL +E L L +Q ++ ++ +L + +N+E+ ++ + +E
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHE 1600
Query: 928 IETATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQL 986
ET + K++ +L+ L+ L G EE +L
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEAIKQLRKL 1650
Query: 987 DLLGNDY---LVSKQVKEYRIQEPNRENSFHS-SIEAIWEECKEIVKASSKKSHQIE-EL 1041
D+ L + I +EN + S+EA + +E + A+ + Q + E
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 1042 EQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQH 1101
E+ E+L + + G N L++++ + E I QL+EEL+E+ ++
Sbjct: 1711 EELAEELASSLSG----RNALQDEKRR--------LEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1102 VVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNL 1161
V + + +L+ E E + + SA+ + + KE L L
Sbjct: 1759 VRKATQQAEQLSN------------ELATERSTAQKNESARQQLERQNKE-----LRSKL 1801
Query: 1162 KEFQEHLQDSVKNT-KDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKL 1220
E + ++ K+T L K +L+E++ Q K+ ++ +Q+ +KL
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE----------KQAATKSLKQKDKKL 1851
Query: 1221 KEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKI 1280
KE L L+ + +RK + KE+ ++KQ+++++ +E + +
Sbjct: 1852 KEIL---------LQVEDERKMAE--QYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 1281 NELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQ 1318
+L+++ ++ ++ + R + LK +L +E Q
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1938
Score = 47.4 bits (111), Expect = 1e-04
Identities = 82/394 (20%), Positives = 171/394 (43%), Gaps = 58/394 (14%)
Query: 1427 MMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLV 1486
++ +T+ +E + E++K E +++ + E+E +QLTE+ + LQ+ + +L
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 1487 AALEIQLKALISSNVQKDNEI------------EQLKRIISETSKIETQIMDIKPK-RIS 1533
A E +++ +++ Q+ EI ++ +++ +E K+ Q++D++ +
Sbjct: 904 AEAE-EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 1534 SADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPE--LEIQFTPLQ 1591
A KLQ E ++ +I K+ED +V+D DQ+ + K LE + + L
Sbjct: 963 EAARQKLQLEKVTAEAKIK--KLEDEILVMD--------DQNNKLSKERKLLEERISDLT 1012
Query: 1592 PN------------KMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTN 1639
N K+ KH + + V++ K K + ++L K + K ++
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR-----QELEKLKRKLEG-DASD 1066
Query: 1640 LKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKK---KEGTLQKFGDF 1696
I+D + + + ++A + + R I N A KK EG + +
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 1697 LQHSPSILQSKAKK----IIETMSSSKLSNVEASKENVSQPK-RAKRKLYTSEISSPID- 1750
L S ++KA+K + E + + K + +Q + RAKR+ + + +D
Sbjct: 1127 LD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 1751 ----ISGQVILMDQKMKESDHQIIKRRLRTKTAK 1780
QV M QK ++ ++ ++ + K AK
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 144 bits (364), Expect = 6e-34
Identities = 237/1079 (21%), Positives = 461/1079 (42%), Gaps = 145/1079 (13%)
Query: 681 KAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRI-KELINIIDQKEDT 739
+AE+AK + + ++EL + D + ELE ++ T + +E + +++Q E+
Sbjct: 375 RAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEE 434
Query: 740 INEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSK---SKICSERKRVNE 796
+ ++L+ +E + K D ++ K + +E+ KD ++ R+R+
Sbjct: 435 KRKVEDLQFRVEE--ESITKGDLEVATVSEK---SRIMELEKDLALRVQEVAELRRRLES 489
Query: 797 NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIEN 856
N+ PA G + +S ++ ++ +E + + + R + E A T +
Sbjct: 490 NK------PA--GDVDMSLSLLQEISSLQE-KLEVTRTDHQREITSLKEHFGAREETHQK 540
Query: 857 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 916
E+K +L+K+ + +L + K+N S + +S + AIA S Q
Sbjct: 541 EIKALYTATEKLSKENESLKSKLEHANKEN---SDVIALWKSKLETAIA------SHQQA 591
Query: 917 QEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGS 976
EE + S + T T + T+I+++R LD +I N+ N +D +
Sbjct: 592 MEELKVSFSKGLGTETAEFAE-------LKTQIEKMR-LDYQHEIENLQ--NQQDSERAA 641
Query: 977 EEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSH 1036
+ + L+ K +KE +ENS +EAI K +
Sbjct: 642 HAKEMEALRAKLM-------KVIKE-------KENS----LEAIRS------KLDKAEDQ 677
Query: 1037 QIEELEQQIEKLQ-AEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTL 1095
+ E+E + KLQ AE+K + E + K E K + QLK +EK + L
Sbjct: 678 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT------KVIDNFTSQLKAT-EEKLLDL 730
Query: 1096 DVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIIL 1155
D + EGK + +L Q + + +IK LE + E S ++ + +++ +E +
Sbjct: 731 DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI---EKNAESSKASSITRELQGRELKLT 787
Query: 1156 KLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQ 1215
L+ NL E + + K + L K + EE + ++Q+ + L KEE+
Sbjct: 788 NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 847
Query: 1216 ETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKL 1275
+ EKL+E L AD++ K + + +E+L AK++++ E+ M ++
Sbjct: 848 DLEKLRENL-----------ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 896
Query: 1276 LRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIE 1335
K+N+ EL +K+R +++L+ +L +A ++ + +K IE
Sbjct: 897 QLTKMND----------ELRLKERDVEELQLKLT------------KANENASFLQKSIE 934
Query: 1336 DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKE----KCNDLETKNNQRSNKEH 1391
DM + + EQ+Q E + E + +E+ER ++LEK E +C +L+ + + +++
Sbjct: 935 DMTV---KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETK 991
Query: 1392 ENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDR 1451
+ ++ L NLQ L ++E K R EE L+ + +E++K A+
Sbjct: 992 TKHEEI---LQNLQKTLLDTEDKLKGAR----EENSGLLQEL--------EELRKQADKA 1036
Query: 1452 ERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLK 1511
+ ++ M+I+ Q+T++ ++ E+ Q A L+ +L L +N++ E+ + K
Sbjct: 1037 KAAQTAEDAMQIM-EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1095
Query: 1512 RIIS-ETSKIETQIMDIKPKRISSADPDK----LQTEPLSTSFEISRNKIEDGSVVLDSC 1566
+++ E K+E +I+ + ++A + LQ E + + E+ R++ E S
Sbjct: 1096 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1155
Query: 1567 EVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLV 1626
E S N+Q K E + + K T+ + + ++ NE V
Sbjct: 1156 ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE-----V 1210
Query: 1627 KCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKK 1686
+NA+ + +L + + VK E KV K + +S + +
Sbjct: 1211 TVLRGENASAK-SLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADED 1269
Query: 1687 EGTLQKFGDFLQHSPSILQSK---AKKIIETMSSSKLSNVEASKENV---SQPKRAKRK 1739
E + DFL LQ K K +E MS + L+ N Q K++K+K
Sbjct: 1270 ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKK 1328
Score = 99.0 bits (245), Expect = 4e-20
Identities = 208/977 (21%), Positives = 399/977 (40%), Gaps = 170/977 (17%)
Query: 295 QKRKMLRLSQDVKGYSFIK-DLQWIQVSDSKEAYRLLK-LGIKHQSVAFTKLNNASSRSH 352
+KRK+ L V+ S K DL+ VS+ L K L ++ Q VA + S++
Sbjct: 434 EKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPA 493
Query: 353 SIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQ---NEGERLRETGNINTSLLT 409
+ + ++ E+S + E++ D ++K E +E + T+
Sbjct: 494 GDVDMSLSLLQ--EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEK 551
Query: 410 LGKCINVLK---------NSE-----KSKFQQHVPFRESKLTHYFQSFFNGKGKIC---- 451
L K LK NS+ KSK + + + + SF G G
Sbjct: 552 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 611
Query: 452 -MIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNS 510
+ I + L Y + L+ +++ + + + KL +K ++ SL++ +
Sbjct: 612 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN-SLEAIRSK 670
Query: 511 KILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLD--KTLEENKAFI 568
+ + E++L L E E V+ELE + N +TK++D K EE
Sbjct: 671 LDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE----- 725
Query: 569 SHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQER 628
KLLDL D +K +E K ++ K+R+++ + E ++
Sbjct: 726 ------KLLDL--DALRKASSEGKSEMK---KLRQQL-------------EAAEKQIKHL 761
Query: 629 EILEENAE--RRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAK 686
EI E+NAE + +I ++L G+ ELK ++ L+
Sbjct: 762 EI-EKNAESSKASSITRELQGR-------------------------ELKLTNLQENLS- 794
Query: 687 TKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTIN----E 742
E+ + KE L+K E L ++ ++++ ++ + ++E +N + QKE+ N +
Sbjct: 795 ---EVSQVKETLEK---ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 848
Query: 743 FQNLKSH---MENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENEL 799
+ L+ + ME F+ D+ + + KL N+ E+ K S S+ ++N+ EL
Sbjct: 849 LEKLRENLADMEAKFREKDEREEQLIKAKEKLE-NDIAEIMKMSGDN-SSQLTKMND-EL 905
Query: 800 QQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELK 859
+ E ++ + ++ K +E IED+ V E ++ + K
Sbjct: 906 RLKERDVEELQLKLT-------KANENASFLQKSIEDMTVKAEQSQ---------QEAAK 949
Query: 860 NEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEE 919
+EEK EL +++LS EKK T + Q++++ Y+ A +E K+K++E +
Sbjct: 950 KHEEEKKEL-------ERKLSDLEKKMETSHNQCQELKARYERATSE---TKTKHEEILQ 999
Query: 920 KIMKLSNEIETATR-------SITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDL 972
+ K + E + + + +++ K +T + QI +
Sbjct: 1000 NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTET 1059
Query: 973 SNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSF----HSSIEAIWEECKEIV 1028
E+ N +L N+ K+ ++E N+ + +E +E + +
Sbjct: 1060 LASLEDTKQTNAKLQ---NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1116
Query: 1029 KASSKKSHQIEELEQQIEKLQAEVKGYKDE---NNRLKEKEHKNQDDLL---KEKETLIQ 1082
+A+++KS Q+ L+++ KL E+ +DE + +L+E+ + LL K + I+
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1176
Query: 1083 QLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK---AKIKELETILETQKVECSH 1139
EE ++ + + E L +L VT + A K L ++++T
Sbjct: 1177 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT------- 1229
Query: 1140 SAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT-----KDLNVKELK---LKEEITQ 1191
LE D ++ E + LE LKE + L S NT +D +E + L I
Sbjct: 1230 ---LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVD 1286
Query: 1192 LTNNLQDMKHLLQLKEE 1208
L QD+K +++ E
Sbjct: 1287 LQRKNQDLKMKVEMMSE 1303
Score = 67.8 bits (164), Expect = 9e-11
Identities = 181/849 (21%), Positives = 349/849 (41%), Gaps = 153/849 (18%)
Query: 204 LSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSLTNSL-----NISEFEESIKDYEQ 258
+SS QEK E+ +++ R+I + H + + + +L +S+ ES+K +
Sbjct: 506 ISSLQEKLEV-TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS-KL 563
Query: 259 ANLNMANSIKFSVWVSFFEI----YNEYIYDLFVPVSS------------KFQKRKM--- 299
+ N NS ++W S E + + + +L V S K Q KM
Sbjct: 564 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 623
Query: 300 -------LRLSQDVKGYSFIKDLQWIQVS---------DSKEAYR--LLKLGIKHQSVAF 341
L+ QD + + K+++ ++ +S EA R L K +H
Sbjct: 624 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 683
Query: 342 TKLNNASSRSHSIFTVKILQIEDSEMSRVI-------RVSELSLCDL-AGSERTMKTQNE 393
LN + +++LQ + +E ++VI + +E L DL A + + + ++E
Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743
Query: 394 GERLRETGNINTSLLTLGKCINVLKNSEKSK---FQQHVPFRESKLTHYFQSFFNGKGKI 450
++LR+ + K + + KN+E SK + + RE KLT+ ++
Sbjct: 744 MKKLRQQLEAAEKQI---KHLEIEKNAESSKASSITRELQGRELKLTNLQEN-------- 792
Query: 451 CMIVNISQCYLAYDETLNVLKFS-------AIAQKVCVPDTLNS--SQEKLFGPVKSSQD 501
+ +SQ ++ L +LK A++ + + +T+N +E+ F + S +
Sbjct: 793 --LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 850
Query: 502 VSLDS---------NSNSKILNVKRATISWENSLEDLME------------------DED 534
++ + + + +A EN + ++M+ E
Sbjct: 851 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER 910
Query: 535 LVEELENAEETQNVETKLLDEDL-DKTLE----ENKAFISHEEKRKLLDL-IEDLKKKLI 588
VEEL+ N L + + D T++ + +A HEE++K L+ + DL+KK+
Sbjct: 911 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM- 969
Query: 589 NEKKEKLTLEFKIR-EEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVG 647
E E K R E T E + + ++TLL + L+ E + ++L
Sbjct: 970 -ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE- 1027
Query: 648 KCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDS 707
+ R++A K A E +A +E Q+ E +T L TK+ K +NE D+
Sbjct: 1028 --ELRKQADKAKAAQTAE--DAMQIME----QMTKEKTETLASLEDTKQTNAKLQNELDT 1079
Query: 708 LIQELETSNKKIITQNQRIKELINIIDQK-EDTINEFQNLKSHMENTFKCNDKADTSSLI 766
L + +N K + + + KEL+ + +QK E+ E + LK K+ S +
Sbjct: 1080 L----KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ------AAAQKSQQLSAL 1129
Query: 767 INNKLICNETVEVPKD---SKSKICSERKRVNENELQ------------QDEPPAKKGSI 811
+ E + +D S K+ ER +N L+ +E + + SI
Sbjct: 1130 QEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1189
Query: 812 HVSSA-ITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNK 870
++SA +TE + E++R E+ +R + + L + + T+E++ + + L
Sbjct: 1190 SITSALLTEKDAELEKLR---NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
Query: 871 QIVHFQQELSLSEKKNLTLSKEVQQIQ-SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 929
Q+ +++LS S T + E ++ Q S D + + + KNQ+ + K+ +S
Sbjct: 1247 QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAAL 1306
Query: 930 TATRSITNN 938
NN
Sbjct: 1307 NGNGDDLNN 1315
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 144 bits (363), Expect = 8e-34
Identities = 197/935 (21%), Positives = 413/935 (44%), Gaps = 113/935 (12%)
Query: 680 IKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDT 739
+ ELA K ++ + ++EL+++ + QELE ++ +R+++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL----KRLQQ----------- 293
Query: 740 INEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENEL 799
E NL S + D+ D + + V V K +S++ ++R+++ E
Sbjct: 294 --ENMNLLSDARSARMYRDELDA---------LREKAVRVDK-LESEVSRYKERLHDIEF 341
Query: 800 QQDEPPAKKGSIHV---SSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIEN 856
+ K V + + EDQ + R + + L++ N L+A L +E
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARS-----DKLHELEKENLQLKAKLHDMEM 396
Query: 857 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 916
E ++++ EL ++ + + S ++L L E++QI +++ A QKS E
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP---QKSLGHE 453
Query: 917 QEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGS 976
E ++E +S+T V +++ T+DSV N +
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELR---------TTVDSVEG-------NASKILKME 497
Query: 977 EEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSH 1036
+E+ + ++++L N+ + KQ +Q + +A E+ E ++ +S++
Sbjct: 498 KENQRLSKKVEILENEIVQEKQ----SLQNCQNLSKDLMKEKAQLEKTIETLRENSER-- 551
Query: 1037 QIEELEQQIEKLQAEVKGYKDENN-----RLK--EKEHKNQDDLLKEKETLIQQLKEELQ 1089
QI+ LEQ+ E L V + + R+K EKE+K + +KE + + +++ E +
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 1090 EKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILE 1149
+ + +++H E EL + + + + L+ + K+ C LEQ+ E
Sbjct: 612 Q----IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 1150 KESIILKLERNLKEFQE---HLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLK 1206
E KL++ L F+ L+ K L+ + L+L+ + L M LQL+
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLE 726
Query: 1207 EEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEV 1266
+E E+ +++ +K E L AS +T+ L+ Q + + L++ L ++ K+I+Q++ E+
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 1267 SVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 1326
+ E++ L+ + +EL + + ++QL+++ N+ +E+ Q E+ K
Sbjct: 787 QDLEMENQTLQKNL-----------EELKISSKRLEQLEKE--NKSLEQETSQLEKDKKQ 833
Query: 1327 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLE-EVERLATELEKWKEKCNDLETKNNQ 1385
L + K + E + T +E++ V LE E + L+ E+ +KE C + K +
Sbjct: 834 LEKENKRLRQQ----AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC--VRLKELE 887
Query: 1386 RSNKEHENNTDV-LGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEM 1444
+ NKE + + L L+++L + EK+ + E + + E+
Sbjct: 888 KENKELVKRATIDIKTLVTLREDL--------------VSEKLKTQQMNNDLEKLTH-EL 932
Query: 1445 KKYAEDRERFFKQQNEMEILTAQLTEK-DSDLQKWREERDQLVAALEIQLKALISSNVQK 1503
+K ++ER + + L K +S L+K E +++ +AALE +L+ + N Q
Sbjct: 933 EKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL 992
Query: 1504 DNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVL 1563
E++ +K+ + + + ++ S + +K + E T+ E+ + K V
Sbjct: 993 RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER 1052
Query: 1564 DSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVK 1598
++ + E Q+ + +LE Q LQ +A++
Sbjct: 1053 NNATLQAEK-QALKTQLKQLETQNNNLQAQILALQ 1086
Score = 143 bits (360), Expect = 2e-33
Identities = 229/1105 (20%), Positives = 473/1105 (42%), Gaps = 176/1105 (15%)
Query: 526 LEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKK 585
+E+L ED ++ E + E Q T+ + L + +EN + + K +++ D+ +
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN---LQLKAKLHDMEMERDMDR 402
Query: 586 KLINE-KKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQE------REILEENAERR 638
K I E +E +TLE ++ + + W + L + E+ E + R
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 639 LAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKT----KGELIKT 694
L + + T EE T V++ E A LK + L+K + E+++
Sbjct: 463 LKLEMENQSLTKTVEELR-----TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 695 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTF 754
K+ L+ +N S L++E K I T + + I I++Q+ + +N+ S +
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ---TVSSLRQRS 574
Query: 755 KCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVS 814
+ + +A + NK++ +E+++ SKI E++++ + EL+ + ++ +
Sbjct: 575 QISAEARVKDIEKENKIL-HESIKETSSKLSKIEFEKRQIKK-ELEHYKEKGERAE-ELE 631
Query: 815 SAITEDQKKSEEVRPNIAEI----EDIRVLQENNEGLRAFLLTIEN-ELKNEKEEKAELN 869
+ + +K++E ++ I + E I L++ N L EN +LK + L
Sbjct: 632 NELHHLEKENELLQKKITNLKITCEKIEALEQENSELER-----ENRKLKKTLDSFKNLT 686
Query: 870 KQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 929
Q+ ++E S +++NL L + V+ ++ + +A+L ++ + + ++E++ K
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCA-SMKMAQLQLENKELESEKEQLKK------ 739
Query: 930 TATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLL 989
+ +K K + L I N L + SN + L + DL
Sbjct: 740 --------GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN-KKIQQLESELQDLE 790
Query: 990 GNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL- 1048
+ + K ++E +I +E + +E K + + +S+ ++LE++ ++L
Sbjct: 791 MENQTLQKNLEELKISSKR--------LEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 1049 -QAEVKGYKDENNRLK----EKEHKN---QDDLLKEKETLIQQLKEELQE--KNVTLDVQ 1098
QAE+K E N +K EKE+K + + KE +++L++E +E K T+D+
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI- 901
Query: 1099 IQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158
+ L L + + K K +++ LE + +H +LE+ L KE + L E
Sbjct: 902 --------KTLVTLREDLVSEKLKTQQMNNDLE----KLTH--ELEKIGLNKERL-LHDE 946
Query: 1159 RNLKEFQEHLQDSVKNT--KDLNVKELK---LKEEITQLTNNLQDMKHLLQLKEEEEET- 1212
++ + + L+ +++T K L +KE K L+ + + TN Q ++ L+ ++ E
Sbjct: 947 QSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1006
Query: 1213 -NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRD 1271
RQ+ E++ + S + + Q + +K++L + V++ + ++
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE-------VERNNATLQA 1059
Query: 1272 EDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKE 1331
E + L+ ++ +LE + N ++ QR L+EQ + + A Q E + + +
Sbjct: 1060 EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN-SQST 1118
Query: 1332 KIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEH 1391
++ L +Q + E + V++ + E+++ L L K EK L ++R E+
Sbjct: 1119 SLMNQNAQLLIQQSSLENENESVIKER-EDLKSLYDSLIKDHEKLELL----HERQASEY 1173
Query: 1392 ENNTDVLGKLT----NLQDELQESEQKYNA--DRKKWLE--EKMMLITQAKEAENIRNKE 1443
E+ G L NL+ E ++ E +YN +K LE EKM+ + Q K +N E
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1233
Query: 1444 M-----KKYAEDRER----FFKQQNEMEILTA--------------QLTEKDSDLQKWRE 1480
KK + +R + + E E+L + T +++ K +E
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
Query: 1481 ERDQL-------------------------------VAALEIQLKALISSN--------V 1501
+ QL + L +Q + L+ N V
Sbjct: 1294 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1353
Query: 1502 QKDNEIEQLKRIISETSKIETQIMD 1526
++ I++L + + K+E +IMD
Sbjct: 1354 EQRQYIDKLNELRRQKEKLEEKIMD 1378
Score = 130 bits (328), Expect = 9e-30
Identities = 243/1126 (21%), Positives = 496/1126 (44%), Gaps = 150/1126 (13%)
Query: 664 VETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQN 723
VE +A A K +++ EL + +L+ K+EL++ E E ++ L+ N +++
Sbjct: 251 VELADAKA----KIRRLRQELEEKTEQLLDCKQELEQMEIE----LKRLQQENMNLLSDA 302
Query: 724 QRIKELINIIDQKEDTINEFQNLKSHMEN-TFKCND----KADTSSLIINNKLICNETVE 778
+ + + +D + L+S + + +D KA L +N+++ ET
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-ETKT 361
Query: 779 VPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIR 838
+ +D + +++E E + + AK + + + D+KK EE+ +E +
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM--DRKKIEELMEENMTLE-MA 418
Query: 839 VLQENNEGLRAFLLTIENELKNEKEEKAEL-NKQIVHFQQELSLS-----EKKNLTLSKE 892
Q +E L L E E + E +E K + H EL+ S E +N +L+K
Sbjct: 419 QKQSMDESLH---LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 893 VQQIQSNYDIA---IAELHVQKSKNQEQEEKIMKLSNEIETATRSITN--NVSQIKLMHT 947
V+++++ D +++ + +NQ +K+ L NEI +S+ N N+S+ LM
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSK-DLMKE 534
Query: 948 KIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEP 1007
K +T++++ + S + L E ++L T L + + E R+++
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQ-----ENEHLNQTVSSLRQRSQISA----EARVKDI 585
Query: 1008 NRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEH 1067
+EN E +K +S K +IE ++QI+K E++ YK++ R +E E+
Sbjct: 586 EKENKI----------LHESIKETSSKLSKIEFEKRQIKK---ELEHYKEKGERAEELEN 632
Query: 1068 K-----NQDDLLKEKETLIQ---QLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCY 1119
+ +++LL++K T ++ + E L+++N L+ + + + + + LT +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 1120 KAKIKEL--ETILETQKVECSHSAKLEQDILEKESIILKLERN-LKEFQEHLQDSVKNTK 1176
+ + +L E + + VE A ++ L+ E+ L+ E+ LK+ E L+ S K T+
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 1177 DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK---EELSASSARTQN 1233
L V L E +L L++ +Q E E + E + L+ EEL SS R +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 1234 LKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQE 1293
L+ + + E++ + L++ +K+ K+++++ + + +KI LEK+ S+E
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 1294 LDMKQRTIQQLK--EQLNNQKVEEA---IQQYERACKDLNVKEKI--------IEDMRMT 1340
+ + + + +LK E+ N + V+ A I+ +DL V EK+ +E +
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL-VSEKLKTQQMNNDLEKLTHE 931
Query: 1341 LEE----------QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKE 1390
LE+ EQ+ ++ ++LE+KLE L LE +EK LE + + +N
Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLEST--LKKSLEIKEEKIAALEARLEESTNYN 989
Query: 1391 HENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAED 1450
+ L+ EL+ ++ Y A +++ EE+M+ + E+ NK ++ E
Sbjct: 990 QQ-----------LRQELKTVKKNYEALKQRQDEERMVQSSPPISGED--NKWERESQET 1036
Query: 1451 RERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQL 1510
K ++ + ++ ++ LQ ++ AL+ QLK L + N +I L
Sbjct: 1037 TRELLKVKDRL----IEVERNNATLQAEKQ-------ALKTQLKQLETQNNNLQAQILAL 1085
Query: 1511 KRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVST 1570
+R +T ++ Q ++ + KLQ E + + + + ++ +++ +
Sbjct: 1086 QR---QTVSLQEQNTTLQTQNA------KLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
Query: 1571 ENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCEN 1630
EN+ + + +L+ + L + K+ +R+++E E + K
Sbjct: 1137 ENESVIK-EREDLKSLYDSLIKDH-------------EKLELLHERQASEYESLISKHGT 1182
Query: 1631 KKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKE-GT 1689
K+A ++ +DR + + K QK + K + + + N T E
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLK-QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1241
Query: 1690 LQKFGDFLQHSPS-------ILQSKAKKIIETMSSSKLSNVEASKE 1728
L D L H+ S +LQ+ K + +++SKL E
Sbjct: 1242 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE 1287
Score = 108 bits (271), Expect = 4e-23
Identities = 220/1045 (21%), Positives = 448/1045 (42%), Gaps = 167/1045 (15%)
Query: 366 EMSRVIRVSELSLCDLAG---------SERTMKTQNEGERLRET-GNINTSLLTL-GKCI 414
E+ ++ R SELS S R +K + E + L +T + T++ ++ G
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 415 NVLK-NSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFS 473
+LK E + + V E+++ QS N + N+S+ +++K
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ-------NLSK---------DLMKEK 535
Query: 474 AIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDE 533
A +K +TL + E+ +K + + N L +R+ IS E ++D+ ++
Sbjct: 536 AQLEKTI--ETLRENSER---QIKILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKEN 589
Query: 534 DLVEELENAEETQNVETKLLDE--DLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEK 591
++ E + +ET + +K+ E + K LE K EK + E+L+ +L + +
Sbjct: 590 KILHE--SIKETSSKLSKIEFEKRQIKKELEHYK------EKG---ERAEELENELHHLE 638
Query: 592 KEKLTLEFKIRE-EVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCD 650
KE L+ KI ++T E + Q ++ ERE ++ L FK+L + +
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSEL------ERE--NRKLKKTLDSFKNLTFQLE 690
Query: 651 TREEAAKDICATKVETE---EATACLELKFNQIKAELAKTKGELIKTKEELKKREN---E 704
+ E+ + +E E+ C +K Q++ E EL KE+LKK
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE----NKELESEKEQLKKGLELLKA 746
Query: 705 SDSLIQELETSNKKIITQNQRIKELINIIDQKEDTI-NEFQNLKSHMENTFKCNDKADTS 763
S + LE S + + +NQR+++ + ++K + +E Q+L+ + K ++ S
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 764 S-----LIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAIT 818
S L NK + ET ++ KD K ++ E KR+ + + + + ++ ++ + +
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKRLRQ-QAEIKDTTLEENNVKIGNLEK 864
Query: 819 EDQKKSEEVRPNIAEIEDIRVLQENNEGL--RAF-----LLTIENELKNEKEEKAELNKQ 871
E++ S+E+ ++ L++ N+ L RA L+T+ +L +EK + ++N
Sbjct: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 872 IVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE-QEEKIMKLSNEIET 930
+ EL L + Q Y + ++L K+ E +EEKI L +E
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984
Query: 931 AT----------RSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDN 980
+T +++ N +K + DE R + S IS D N E ++
Sbjct: 985 STNYNQQLRQELKTVKKNYEALK---QRQDEERMVQSSPPISGED--------NKWERES 1033
Query: 981 LPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEE 1040
T+ +LL +VK+ I+ + + +A+ + K++ ++ QI
Sbjct: 1034 QETTR-ELL--------KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
Query: 1041 LEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQ 1100
L++Q LQ + + +N +L+ ++ L + T + +L + +L+ + +
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQV-----ENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1139
Query: 1101 HVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERN 1160
V++ + L L Y + IK+ E K+E H E+ E ES+I K
Sbjct: 1140 SVIKEREDLKSL------YDSLIKDHE------KLELLH----ERQASEYESLISK-HGT 1182
Query: 1161 LKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKL 1220
LK ++L+ ++ +D + LK K ++ L L+ + + L+ + ET E +KL
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1242
Query: 1221 --------------KEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEV 1266
+E +NLK+ L + + L+ + + K+Q +Q+
Sbjct: 1243 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1302
Query: 1267 SVMRDEDKLLRIKINELEKK-------------KNQCSQELDMKQRTIQQLKEQLNNQKV 1313
+ + ++ +LL LE++ +N+ E +M+ + + ++++ K+
Sbjct: 1303 TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
Query: 1314 EEAIQQYERACKDLNVKEKIIEDMR 1338
E +Q E+ ++EKI++ +
Sbjct: 1363 NELRRQKEK------LEEKIMDQYK 1381
Score = 77.0 bits (188), Expect = 1e-13
Identities = 158/790 (20%), Positives = 329/790 (41%), Gaps = 138/790 (17%)
Query: 1056 KDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQI--QHVVEGKRALSELT 1113
K E+ R+ +K + + + L++Q+K QE L + ++ GK SE
Sbjct: 58 KLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSE-- 115
Query: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK 1173
QG ++K+L +L V+C K E+ I + + + + + + + +
Sbjct: 116 QGTE----EVKKLLLLLLGCAVQCQ---KKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE 168
Query: 1174 NTKDLNVKELK--LKEEITQLTNNLQ-DMKHLLQLKEEEEET------------------ 1212
N DL E+ +E+I L N+ +K L+ ++E ET
Sbjct: 169 NVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHAS 228
Query: 1213 -------------NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI 1259
+ + L EL+ + A+ + L+ +L+ K E D K++L + ++
Sbjct: 229 SSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL 288
Query: 1260 KQVQKE----------VSVMRDEDKLLRIKINELEKKKNQCSQ------ELDMKQRTIQQ 1303
K++Q+E + RDE LR K ++K +++ S+ +++ + +++
Sbjct: 289 KRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE 348
Query: 1304 LKE--------------QLNNQKV-EEAIQQYERACKDLNVK-----------EKIIEDM 1337
LKE QL + + + + E+ L K K IE++
Sbjct: 349 LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408
Query: 1338 ---RMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEK-----CNDLETKNNQRSNK 1389
MTLE ++ +++ L +LE++ R +EL + +K N+L + +
Sbjct: 409 MEENMTLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 1390 EHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAE 1449
E+++ T + +L D ++ + K K+ +++ + E E ++ K+ + +
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKE--NQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 1450 DRER-FFKQQNEMEILTAQLTEKDSD----LQKWREERDQLVAAL----EIQLKALISSN 1500
+ + K++ ++E L E L++ E +Q V++L +I +A + +
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARV-KD 584
Query: 1501 VQKDNEI--EQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIED 1558
++K+N+I E +K S+ SKIE + IK K + + E L + E
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIK-KELEHYKEKGERAEELENELHHLEKENEL 643
Query: 1559 GSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKS 1618
+ + +++ E ++ ELE + L+ + K+ +T ++ K S
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN------LTFQLESLEKENS 697
Query: 1619 NEMEEDL--------VKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSL 1670
EE+L +KC + K A + L+ + +KK ++ ++ S KKT
Sbjct: 698 QLDEENLELRRNVESLKCASMKMA--QLQLENKELESEKEQLKKGLEL-LKASFKKTE-- 752
Query: 1671 RSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQ------SKAKKIIETM--SSSKLSN 1722
R + S G+++ ++ + TL+ +Q S LQ +K +E + SS +L
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 1723 VEASKENVSQ 1732
+E +++ Q
Sbjct: 813 LEKENKSLEQ 822
>gi|46852174 kinesin family member 3A [Homo sapiens]
Length = 699
Score = 144 bits (362), Expect = 1e-33
Identities = 140/514 (27%), Positives = 244/514 (47%), Gaps = 73/514 (14%)
Query: 268 KFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKM-LRLSQDVKGYSFIKDLQWIQVSDSKEA 326
+F V VS+ EIYNE + DL K Q +++ ++ DV Y IKDL V+++ +
Sbjct: 142 RFLVRVSYLEIYNEEVRDLL----GKDQTQRLEVKERPDVGVY--IKDLSAYVVNNADDM 195
Query: 327 YRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDS-EMSRVIRVSELSLCDLAGSE 385
R++ LG K++SV T +N SSRSH+IFT+ I E + + +R+ +L L DLAGSE
Sbjct: 196 DRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSE 255
Query: 386 RTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFN 445
R KT G+RL+E IN SL TLG I+ L + + + HVP+R SKLT Q
Sbjct: 256 RQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKST----HVPYRNSKLTRLLQDSLG 311
Query: 446 GKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLD 505
G K M NI YDET++ L+++ A+ + ++
Sbjct: 312 GNSKTMMCANIGPADYNYDETISTLRYANRAKNI-------------------KNKARIN 352
Query: 506 SNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENK 565
+ +L + E E+L ++LE EE + +ED D EE +
Sbjct: 353 EDPKDALLR------------QFQKEIEELKKKLEEGEEISGSDISGSEEDDD---EEGE 397
Query: 566 AFISHEEKRKLL-------DLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREA 618
E+++K D + +++ K I+E+++ L + + EE + +RE
Sbjct: 398 VGEDGEKRKKRRGKKKVSPDKMIEMQAK-IDEERKALETKLDMEEEERNKARAELEKREK 456
Query: 619 DFKETLLQEREILEENA--ERRLAI-FKDLVGKCDTREEAAKDICATKVETEEATACLEL 675
D + + + +LE+ + E+++ + DL+ K + +E+ ++ + +E EE E
Sbjct: 457 DLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEE---SNMELEERRKRAE- 512
Query: 676 KFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQ 735
Q++ EL + + E + +E+ + E+ ++L KK+ T K + D
Sbjct: 513 ---QLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKL----KKVWTMLMAAKS--EMADL 563
Query: 736 KEDTINEFQNLKSHMENTFKCNDKADTSSLIINN 769
+++ E + L +EN + + + LII+N
Sbjct: 564 QQEHQREIEGL---LENIRQLSRELRLQMLIIDN 594
Score = 58.5 bits (140), Expect = 5e-08
Identities = 46/188 (24%), Positives = 85/188 (45%), Gaps = 24/188 (12%)
Query: 46 PNTEANSFESKDYLQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKS 105
P ++ ES D ++V +R RP + EK + C Q V + E + + S
Sbjct: 2 PINKSEKPESCDNVKVVVRCRPLNEREKSM----CY----KQAVSVDEMRGTITVHKTDS 53
Query: 106 SGQMAQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGT 165
S + + F+F VFGP + Q + + + +L+G + IF YG T +GKT+T +G
Sbjct: 54 SNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGV 113
Query: 166 E---ENIGILPRTLNVLFDSLQE-----RLYTKMNLKPHRSREYLRLSSEQEKEEIASKS 217
E GI+P + +F + + R +++ YL + +E+ ++ +
Sbjct: 114 RAIPELRGIIPNSFAHIFGHIAKAEGDTRFLVRVS--------YLEIYNEEVRDLLGKDQ 165
Query: 218 ALLRQIKE 225
++KE
Sbjct: 166 TQRLEVKE 173
Score = 50.4 bits (119), Expect = 1e-05
Identities = 107/531 (20%), Positives = 222/531 (41%), Gaps = 73/531 (13%)
Query: 1015 SSIEAIWEECKEIVKASSKKSHQIEELEQ---QIEKLQAEVKGYKDENNRLKEKEHKNQD 1071
S +E EE ++++ + +++E I+ L A V D+ +R+ HKN+
Sbjct: 148 SYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRS 207
Query: 1072 ------DLLKEKETLIQQLKEELQEKNVTLDVQIQ----HVVEGKRALSELTQGVTCYKA 1121
+ + I + E EK + ++ ++ H+V+ + + G T +
Sbjct: 208 VGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRL 267
Query: 1122 KIKELETILETQKVECSHSA--KLEQDILEKESIILKLERNLKEFQEHLQDSVK-NTK-- 1176
K E K+ S S + +++ +S + RN K LQDS+ N+K
Sbjct: 268 K--------EATKINLSLSTLGNVISALVDGKSTHVPY-RNSK-LTRLLQDSLGGNSKTM 317
Query: 1177 ---DLNVKELKLKEEITQL--TNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSART 1231
++ + E I+ L N +++K+ ++ E+ ++ ++ +K EEL
Sbjct: 318 MCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEG 377
Query: 1232 QNLK-ADLQRKEEDYADLKEKLTDAKKQIKQV-QKEVSVMRDEDKLLRIKINELEKKKNQ 1289
+ + +D+ EED + E D +K+ K+ +K+VS DK++ ++ ++++++
Sbjct: 378 EEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKKKVS----PDKMIEMQA-KIDEERKA 432
Query: 1290 CSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQV 1349
+LDM++ E+ N + E E+ KDL ++ + + L E+ +
Sbjct: 433 LETKLDMEE-------EERNKARAE-----LEKREKDLLKAQQEHQSLLEKLSALEKKVI 480
Query: 1350 EQDQVLEAKLEEVERLATELE-KWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDEL 1408
L AK EE E+L E + +E+ E + KE E D+ K T+LQ+E
Sbjct: 481 VGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQE-RLDIEEKYTSLQEEA 539
Query: 1409 QESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEI----- 1463
Q +K +K W ML+ E +++ + ++ E + E+ +
Sbjct: 540 QGKTKKL---KKVW----TMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLII 592
Query: 1464 ---LTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLK 1511
+ E + W E+ + +++ A +N++K + K
Sbjct: 593 DNFIPRDYQEMIENYVHWNED----IGEWQLKCVAYTGNNMRKQTPVPDKK 639
Score = 50.4 bits (119), Expect = 1e-05
Identities = 54/227 (23%), Positives = 102/227 (44%), Gaps = 17/227 (7%)
Query: 1319 QYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCND 1378
+Y K++ K +I ED + L Q Q ++E+ L+ KLEE E ++ E+ +D
Sbjct: 337 RYANRAKNIKNKARINEDPKDALLRQFQKEIEE---LKKKLEEGEEISGSDISGSEEDDD 393
Query: 1379 LETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAEN 1438
E + + K + GK D++ E + K + +RK L T+ E
Sbjct: 394 EEGEVGEDGEKRKKRR----GKKKVSPDKMIEMQAKIDEERKA-------LETKLDMEEE 442
Query: 1439 IRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALIS 1498
RNK + + + K Q E + L +L+ + + + L+A E Q K L
Sbjct: 443 ERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVD---LLAKAEEQEKLLEE 499
Query: 1499 SNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPL 1545
SN++ + ++ +++ E + E + +DI+ K S + + +T+ L
Sbjct: 500 SNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKL 546
>gi|4758646 kinesin family member 3B [Homo sapiens]
Length = 747
Score = 143 bits (361), Expect = 1e-33
Identities = 132/511 (25%), Positives = 235/511 (45%), Gaps = 51/511 (9%)
Query: 255 DYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKD 314
D+ +++ + + ++ V S+ EIY E I DL SK Q ++ L L + ++KD
Sbjct: 124 DHIFTHISRSQNQQYLVRASYLEIYQEEIRDLL----SKDQTKR-LELKERPDTGVYVKD 178
Query: 315 LQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMS----RV 370
L KE ++ +G +++SV T +N SSRSH+IF ++ IE SE+
Sbjct: 179 LSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIF---VITIECSEVGLDGENH 235
Query: 371 IRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVP 430
IRV +L+L DLAGSER KT +GERL+E IN SL LG I+ L + + + H+P
Sbjct: 236 IRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKST----HIP 291
Query: 431 FRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQE 490
+R+SKLT Q G K M+ N+ +ETL L+++ A+ + +N +
Sbjct: 292 YRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPK 351
Query: 491 KLFGPVKSSQDVSLDSNSNSKILNVKR--------------ATISWENSLEDLMEDEDLV 536
+ L + + + ++ E E E +D
Sbjct: 352 DALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKD 411
Query: 537 EELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLT 596
+ +E +E + + ED EE + +EK+ +EDL+++ + E L
Sbjct: 412 DYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKK-----MEDLRRE--KDAAEMLG 464
Query: 597 LEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAA 656
+ K E + + ++ L Q+R+ + E R I + + + + E
Sbjct: 465 AKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELK 524
Query: 657 KDICATKVETEEATACLELKFNQ---IKAELAKTKGELIKTKEELKKRENESDSLIQELE 713
+ + + E + T L+ F++ +KAE+ + E IK ++EL++ +NE L +EL+
Sbjct: 525 ETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNE---LTRELK 581
Query: 714 TSNKKIITQN----QRIKELIN--IIDQKED 738
K +I +N + +++N D++ED
Sbjct: 582 L--KHLIIENFIPLEEKSKIMNRAFFDEEED 610
Score = 50.8 bits (120), Expect = 1e-05
Identities = 119/617 (19%), Positives = 250/617 (40%), Gaps = 104/617 (16%)
Query: 805 PAKKGSI-----HVSSAITEDQKKSEEVRPNIAEI--EDIRVLQENNEGLRAFLLTIENE 857
P K+G I H+ + I+ Q + VR + EI E+IR L ++ R E
Sbjct: 113 PEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRL-------E 165
Query: 858 LKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQ 917
LK E+ + K + F ++K V++I+ HV NQ +
Sbjct: 166 LK-ERPDTGVYVKDLSSF-------------VTKSVKEIE----------HVMNVGNQNR 201
Query: 918 EEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNL-RDLSNGS 976
+ +N E ++RS V I+ +D + V +++ +DL R G+
Sbjct: 202 S---VGATNMNEHSSRSHAIFVITIECSEVGLDGENHI-RVGKLNLVDLAGSERQAKTGA 257
Query: 977 EEDNLP-----NTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIE-AIWEECKEIVKA 1030
+ + L N L LGN ++S V P R++ ++ ++ K ++ A
Sbjct: 258 QGERLKEATKINLSLSALGN--VISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVA 315
Query: 1031 S-SKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDD---LLKEKETLIQQLKE 1086
+ S+ +EE + Y + +K K N+D LL+E + I +LK
Sbjct: 316 NVGPASYNVEETLTTLR--------YANRAKNIKNKPRVNEDPKDALLREFQEEIARLKA 367
Query: 1087 ELQEKNVTLDVQIQ--------------HVVEGKRALSELTQGVTCYKAKIKELETILET 1132
+L+++++ + + EG+ E ++ + ++LE +E
Sbjct: 368 QLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLE--IEK 425
Query: 1133 QKVECSHSAKLEQD---ILEKESIILKLERN----------LKEFQEHLQDSVKNTKDLN 1179
+ + HS E+ + EKE + L R +K + L KN D
Sbjct: 426 RAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHT 485
Query: 1180 VKELKL----KEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK 1235
++ K+ ++EI + ++++ ++ ++EE ++ L++E+ + + + L
Sbjct: 486 NEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLF 545
Query: 1236 ADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD 1295
+ LQ + + DL+E+ +++++Q Q E++ L+ LE+K ++
Sbjct: 546 SKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSKIMNRAFF 605
Query: 1296 MKQRTIQQLK--EQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQ 1353
++ +L +L NQ Q +R + K + + RM++ + + + +
Sbjct: 606 DEEEDHWKLHPITRLENQ------QMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAEN 659
Query: 1354 VLEAKLEEVERLATELE 1370
++ +L+ R + E
Sbjct: 660 IVLLELDMPSRTTRDYE 676
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 143 bits (361), Expect = 1e-33
Identities = 213/1044 (20%), Positives = 449/1044 (43%), Gaps = 130/1044 (12%)
Query: 539 LENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLE 598
L++AE + + T + ED ++T EE ++ E R+ ++L++K+++ +EK L+
Sbjct: 844 LKSAEAEKEMAT--MKEDFERTKEE----LARSEARR-----KELEEKMVSLLQEKNDLQ 892
Query: 599 FKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKD 658
+++ E T+ + E K +L E ++ K+L + + EE +
Sbjct: 893 LQVQSE-TENLMDAEERCEGLIKSKILLEAKV------------KELTERLEEEEEMNSE 939
Query: 659 ICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKK 718
+ A K E+ + L+ + ++ L K + E T+ ++K E +L + + K+
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKE 999
Query: 719 IITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICN-ETV 777
+ + ++ ++ + +ED +N + + +E D + SL KL + E
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQ---TDDLE-GSLEQEKKLRADLERA 1055
Query: 778 EVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVS---SAITEDQKKSEEVRPNIAEI 834
+ + K+ E EN+ QQ E KK +S + I ++Q S + + I E+
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 835 ED-IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEV 893
+ I L+E E IE + + E E+++++ S + N E
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF 1175
Query: 894 QQIQSNYDIAIAELHVQKSK-NQEQEEKIMKLSNEIETATR---SITNNVSQIKLMHTKI 949
Q+++ + + A + + ++Q + + +L +I+ R + S++K+ +I
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKM---EI 1232
Query: 950 DELRT-LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPN 1008
D++ + ++++S+ + R + + E + Q L +D + K R+Q N
Sbjct: 1233 DDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKA----RLQTQN 1288
Query: 1009 RENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHK 1068
E S +E ++ K+ + Q+EEL++Q+E+ E K + L+ H
Sbjct: 1289 GELSHR--VEEKESLISQLTKSKQALTQQLEELKRQMEE---ETKAKNAMAHALQSSRH- 1342
Query: 1069 NQDDLLKEKETLIQQLKEELQEKNVTLDVQI-----QHVVEGKRALSELTQGVTCYKAKI 1123
DLL+E+ Q+ K ELQ + ++ ++ + + EL + ++
Sbjct: 1343 -DCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 1124 KELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKEL 1183
+E E ET +C+ K +Q +L+ +++ L+ S L+ K+
Sbjct: 1402 QEAEENTETANSKCASLEKTKQ----------RLQGEVEDLMRDLERSHTACATLDKKQR 1451
Query: 1184 KLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEE 1243
+ + + L + + L+ ++E + E K++ + + L+ + + +E
Sbjct: 1452 NFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQE 1511
Query: 1244 DYADLKEKLTDAKKQIKQVQK-------------------EVSVMRDEDKLLRIKINELE 1284
+ +DL E++ + K +++ +K E S+ +E K+LR+++ EL
Sbjct: 1512 EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL-ELS 1570
Query: 1285 KKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQY----ERACKD-LNVKEKIIEDM-- 1337
+ K++ +++ K I+QLK N+Q+ EA+Q R+ D L +K+K+ D+
Sbjct: 1571 QVKSELDRKVIEKDEEIEQLKR--NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNE 1628
Query: 1338 ---------RMTLEEQEQTQVEQDQV----------------LEAKLEEVER----LATE 1368
R E Q+ + Q Q+ L+ +L VER L E
Sbjct: 1629 MEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEE 1688
Query: 1369 LEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMM 1428
LE+ K E + + S +E + +D + L + L +++K AD + E
Sbjct: 1689 LEEMKVALEQTE-RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 1429 LITQAKEAENIRNKEMKKYAEDRERFFKQQN---EMEILTAQLTEKDSDLQKWREERDQL 1485
I +++ AE K + A E K+Q+ +E + L + DLQ +E +QL
Sbjct: 1748 SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 1486 -VAALEIQLKALISSNVQKDNEIE 1508
+ + Q++ L + + +NE++
Sbjct: 1808 ALKGGKKQIQKLENRVRELENELD 1831
Score = 131 bits (330), Expect = 5e-30
Identities = 195/903 (21%), Positives = 387/903 (42%), Gaps = 149/903 (16%)
Query: 663 KVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQE---------LE 713
K++ +A E + +K + +TK EL +++ K+ E + SL+QE E
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 714 TSN------------KKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCND-KA 760
T N K I ++KEL ++++E+ +E K ++E+ KC+ K
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLED--KCSSLKR 956
Query: 761 DTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITED 820
D L + + K K K +E K N +E E A + +I S +T++
Sbjct: 957 DIDDL----------ELTLTKVEKEKHATENKVKNLSE----EMTALEENI---SKLTKE 999
Query: 821 QKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENE-------LKNEKEEKAELNKQIV 873
+K +E ++D++V ++ GL +E + L+ EK+ +A+L +
Sbjct: 1000 KKSLQEAHQQ--TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR 1057
Query: 874 HFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATR 933
+ +L +S++ + L + QQI+ EL ++K +++ ++ +I+
Sbjct: 1058 KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117
Query: 934 SITNNVSQIKLMHT---KIDELRTLDSVSQISNIDLL-NLRDLSNGSEE-DNLPNTQLDL 988
I +I+ HT KI++ R+ DL L ++S EE + Q+++
Sbjct: 1118 RIEELEEEIEAEHTLRAKIEKQRS----------DLARELEEISERLEEASGATSAQIEM 1167
Query: 989 LGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL 1048
+ +E Q+ R+ EA + K++ + EL +QI+ L
Sbjct: 1168 --------NKKREAEFQKMRRDLE-----EATLQHEATAATLRKKQADSVAELGEQIDNL 1214
Query: 1049 QAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRA 1108
Q + + E + LK DD+ E L + K ++ T++ Q +
Sbjct: 1215 QRVKQKLEKEKSELK----MEIDDMASNIEAL-SKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 1109 LSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHL 1168
++L + KA+ L+TQ E SH + EKES+I +L ++ + + L
Sbjct: 1270 QTQLIHDLNMQKAR-------LQTQNGELSHRVE------EKESLISQLTKSKQALTQQL 1316
Query: 1169 QDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASS 1228
++ + ++ E K K + + LQ +H L E+ E ++ +L+ LS ++
Sbjct: 1317 EELKRQMEE----ETKAK---NAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369
Query: 1229 ARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKN 1288
+ + + E D E+L +AKK++ Q ++ E E+
Sbjct: 1370 SEVAQWRT---KYETDAIQRTEELEEAKKKLAQ-----------------RLQEAEENTE 1409
Query: 1289 QCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYER---ACKDLNVKEKIIEDMRMTLEEQE 1345
+ + ++T Q+L+ + VE+ ++ ER AC L+ K++ + + L E +
Sbjct: 1410 TANSKCASLEKTKQRLQGE-----VEDLMRDLERSHTACATLDKKQRNFDKV---LAEWK 1461
Query: 1346 QTQVEQDQVLEAKLEEVERLATELEK----WKEKCNDLETKNNQRSNKEHENNTDVLGKL 1401
Q E LEA +E L+TEL K ++E + LET + N + E +D+ ++
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQ-EEISDLTEQI 1520
Query: 1402 TNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEM 1461
LQE+E+ +K +EK L +E E E K + + ++E+
Sbjct: 1521 AETGKNLQEAEK----TKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSEL 1576
Query: 1462 EILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIE 1521
+ ++ EKD ++++ + + AL+ L A I S +++ + K++ + +++E
Sbjct: 1577 D---RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRS---RNDALRLKKKMEGDLNEME 1630
Query: 1522 TQI 1524
Q+
Sbjct: 1631 IQL 1633
Score = 128 bits (321), Expect = 6e-29
Identities = 178/888 (20%), Positives = 376/888 (42%), Gaps = 161/888 (18%)
Query: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIID 734
LK + + E+A K + +TKEEL + S++ +ELE +++++++
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELAR----SEARRKELE-------------EKMVSLLQ 886
Query: 735 QKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRV 794
+K D + Q S EN ++ + +I +K++ ++K+ +R+
Sbjct: 887 EKNDLQLQVQ---SETENLMDAEERCEG---LIKSKILL----------EAKVKELTERL 930
Query: 795 NENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTI 854
E E E AKK ++ + K ++ +I ++E LT+
Sbjct: 931 EEEEEMNSELVAKKRNL---------EDKCSSLKRDIDDLE----------------LTL 965
Query: 855 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 914
K EKE+ A NK + + +E++ E+ L+KE + +Q + + +L V++ K
Sbjct: 966 T---KVEKEKHATENK-VKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDK- 1020
Query: 915 QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDEL-RTLDSVSQISNIDLLNLRDLS 973
++K++ ++E T + ++ Q K + ++ R L+ ++S +++L +
Sbjct: 1021 ---VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077
Query: 974 NGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1033
EE L K+ + ++Q + HS +
Sbjct: 1078 QQIEEK--------------LKKKEFELSQLQAKIDDEQVHSL----------------Q 1107
Query: 1034 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV 1093
+I+EL+ +IE+L+ E++ + L+ K K + DL +E E + ++L+E +
Sbjct: 1108 FQKKIKELQARIEELEEEIEA----EHTLRAKIEKQRSDLARELEEISERLEEASGATSA 1163
Query: 1094 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESI 1153
+++ + E ++ +L + ++A T +K + A+L + I + +
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEA------TAATLRKKQADSVAELGEQIDNLQRV 1217
Query: 1154 ILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETN 1213
KLE+ E + + D N + L+ K K I + ++D ++ K+E++
Sbjct: 1218 KQKLEKEKSELKMEIDDMASNIEALS----KSKSNIERTCRTVEDQFSEIKAKDEQQT-- 1271
Query: 1214 RQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVS-VMRDE 1272
+L +L+ AR Q +L + E+ L +LT +K+ + Q +E+ M +E
Sbjct: 1272 -----QLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326
Query: 1273 DKLLRIKINELEKKKNQCS---QELDMKQRTIQQLKEQLN--NQKVEEAIQQYE----RA 1323
K + L+ ++ C ++ + +Q +L+ L+ N +V + +YE +
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 1324 CKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLE----EVERLATELEKWKEKCNDL 1379
++L +K + EE +T + LE + EVE L +LE+ C L
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 1380 ETKNN--------------------QRSNKEHENNTDVLGKLTNLQDELQESEQKYNADR 1419
+ K + + KE + + L K+ N +E+ + + +
Sbjct: 1447 DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRREN 1506
Query: 1420 KKWLEEKMMLITQ-AKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1478
K EE L Q A+ +N++ E K ++E+ Q +E + L ++S + +
Sbjct: 1507 KNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKS-DLQVALEEVEGSLEHEESKILRV 1565
Query: 1479 REERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMD 1526
+ E Q+ + L+ ++ ++KD EIEQLKR ++ ++D
Sbjct: 1566 QLELSQVKSELDRKV-------IEKDEEIEQLKRNSQRAAEALQSVLD 1606
Score = 121 bits (304), Expect = 5e-27
Identities = 210/1112 (18%), Positives = 467/1112 (41%), Gaps = 146/1112 (13%)
Query: 344 LNNASSRSHSIFTVKIL-QIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGN 402
L +A R + KIL + + E++ + E +L +R ++ + + R+ +
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK-RDIDD 960
Query: 403 INTSLLTLGKCINVLKNSEKSKFQQHVPFRE--SKLTHYFQSFFNGKGKICMIVNISQCY 460
+ +L + K + +N K+ ++ E SKLT +S + + + +
Sbjct: 961 LELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE-- 1018
Query: 461 LAYDETLNVLKFSA------------IAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNS 508
D+ ++K +A + Q+ + L ++ KL G +K SQ+ +D +
Sbjct: 1019 ---DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN 1075
Query: 509 NSKILNVKRATISWENS-LEDLMEDEDL---------------VEELEN---AEETQNVE 549
+ + + K +E S L+ ++DE + +EELE AE T +
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK 1135
Query: 550 TKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEF 609
+ DL + LEE I+E+ E+ + + E+ ++
Sbjct: 1136 IEKQRSDLARELEE------------------------ISERLEEASGATSAQIEMNKKR 1171
Query: 610 TQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCD----TREEAAKDICATKVE 665
+ + D +E LQ +++ +L + D +++ K+ K+E
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 666 TEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQN-- 723
++ + +E ++ K+ + +T + E+K ++ + LI +L ++ TQN
Sbjct: 1232 IDDMASNIE-ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE 1290
Query: 724 --QRIKELINIIDQ----KEDTINEFQNLKSHMENTFKC-NDKADTSSLIINNKLICNET 776
R++E ++I Q K+ + + LK ME K N A ++ + E
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350
Query: 777 VEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIED 836
E +++K+++ + N +E+ Q + +I + + E +KK +
Sbjct: 1351 YEEEQEAKAELQRALSKAN-SEVAQWRTKYETDAIQRTEELEEAKKKL---------AQR 1400
Query: 837 IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQI 896
++ +EN E T ++ + ++ K L ++ ++L S TL K+
Sbjct: 1401 LQEAEENTE-------TANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKK---- 1449
Query: 897 QSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLD 956
Q N+D +AE + ++Q + E K S + T + N ++ +D+L TL
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV------VDQLETL- 1502
Query: 957 SVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1016
R+ N EE + Q+ G + +++ K+ QE +
Sbjct: 1503 ------------RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEE 1550
Query: 1017 IEAIWE-ECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLK 1075
+E E E +I++ + S EL++++ + E++ K + R E D ++
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610
Query: 1076 EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKV 1135
+ + +LK++++ +++Q+ H R ++E + + + ++K+ + L+ +
Sbjct: 1611 SRNDAL-RLKKKMEGDLNEMEIQLGH---SNRQMAETQKHLRTVQGQLKDSQLHLD-DAL 1665
Query: 1136 ECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKEL--------KLKE 1187
+ K + I+E+ + +L E L+E + L+ + + T+ L+ +EL L
Sbjct: 1666 RSNEDLKEQLAIVERRNGLLLEE--LEEMKVALEQT-ERTRRLSEQELLDASDRVQLLHS 1722
Query: 1188 EITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYAD 1247
+ T L N + ++ + + E E + QE+ +E+ + + +L+++++ A
Sbjct: 1723 QNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782
Query: 1248 LKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIK-----INELEKKKNQCSQELDMKQ-RTI 1301
L+ KK ++Q K++ DE + L +K I +LE + + ELD++Q R
Sbjct: 1783 LER----MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGA 1838
Query: 1302 QQLK-EQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLE 1360
+ LK +KV+E Q E K++ + +++ ++ ++ ++ E ++ +L
Sbjct: 1839 EALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLS 1898
Query: 1361 EVERLATELEKWKEKCNDLETKNNQRSNKEHE 1392
R+ ELE+ E+ + E++ N+ K +
Sbjct: 1899 RCRRVQHELEEAAERADIAESQVNKLRAKSRD 1930
Score = 37.7 bits (86), Expect = 0.10
Identities = 69/354 (19%), Positives = 146/354 (41%), Gaps = 49/354 (13%)
Query: 1426 KMMLITQAKEAENIRNKEMKKYAEDRERFFKQ-------QNEMEILTAQLTEKDSDLQKW 1478
K+ + ++ EAE KEM ED ER ++ + E+E L ++ +DLQ
Sbjct: 839 KIKPLLKSAEAE----KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQ 894
Query: 1479 REERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPD 1538
+ + + E + + LI S + + ++++L + E ++ ++++ K
Sbjct: 895 VQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL 954
Query: 1539 KLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVK 1598
K + L E++ K+E + +T L + T L+ N +
Sbjct: 955 KRDIDDL----ELTLTKVE-------------KEKHATENKVKNLSEEMTALEENISKL- 996
Query: 1599 HPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTNLKF-PISDDRNSSVKKEQK 1657
K K+ + + +DL E+K N + N K +DD S+++E+K
Sbjct: 997 ---------TKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKK 1047
Query: 1658 VAI---RPSSKKTYSLR-SQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKA--KKI 1711
+ R K L+ SQ SI+ + ++ E L+K + S LQ+K +++
Sbjct: 1048 LRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKK----KEFELSQLQAKIDDEQV 1103
Query: 1712 IETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVILMDQKMKES 1765
K+ ++A E + + A+ L D++ ++ + ++++E+
Sbjct: 1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 142 bits (358), Expect = 3e-33
Identities = 238/1191 (19%), Positives = 493/1191 (41%), Gaps = 202/1191 (16%)
Query: 500 QDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAE---ETQNVETKLLDED 556
Q ++ DSNSN K +K N ++L E E L E L+ + +N + L ED
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 557 LDKTLEENKAFISHE--EKRKLLDLIEDLKKKLINE---KKEKLTLEFKIREEVTQEFTQ 611
+ LEE A + EK +++ ++ K ++ E K++L E E+ +E +
Sbjct: 689 VRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSN 748
Query: 612 YWAQREADFKETLLQEREILEENAERRLAI--FKDLVGKCDTREEAAKDICATKVETEEA 669
R + L+ +++ N ++ + I K + + DT + KD+ ++ +E ++
Sbjct: 749 ---ARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQ 805
Query: 670 TACL----ELKFNQIKAELAKTKGELIKTKEELKKRE------NESDSLIQELETSNKKI 719
L E+ ++K +K + EL K + L+K E E D + ++ N +
Sbjct: 806 LTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHL 865
Query: 720 ITQNQRIKE------------LINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLII 767
+ +R++E ++ + + +++ +K H+E K + K
Sbjct: 866 QEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI------- 918
Query: 768 NNKLICNETVEVPKDSKSKICS----ERKRVNENELQQDEPPAKKGSIHVSS--AITEDQ 821
+E SK ++ ++K ++E Q ++ A + + I Q
Sbjct: 919 ---------IEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQ 969
Query: 822 KKSEEVRPNIAEIEDIRVLQENNEGL----RAFLLTIENELKNEKEEKAE---LNKQIVH 874
K E+++ + E + + +Q +N + + L IEN + KAE L K I
Sbjct: 970 KTIEQIKTQLHE--ERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKE 1027
Query: 875 FQQELSLSEKKNLTLSKEVQQIQSNY-----------DIAIAELHVQKSKNQEQEEKIMK 923
+ E+ L +KN++L+K++ Q+ + D+ I LH + S ++ ++
Sbjct: 1028 RELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQD-VVY 1086
Query: 924 LSNEIETATRSITN-----NVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEE 978
L +++ N + H K + + +D V+ L+ L+D E
Sbjct: 1087 LQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAA-KEAALIKLQD------E 1139
Query: 979 DNLPNTQLDLLGNDYL------VSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIV---- 1028
+ +T+ + G D +S+ ++E I+ I+A+ ++C+ ++
Sbjct: 1140 NKKLSTRFESSGQDMFRETIQNLSRIIREKDIE-----------IDALSQKCQTLLAVLQ 1188
Query: 1029 ------KASSKKSHQIEELEQQIEKLQAEVKGYKD--------------ENNRLKEKEHK 1068
+A S+Q EEL Q+ +KL+ +VK ++ E+ +L+E+ H+
Sbjct: 1189 TSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ 1248
Query: 1069 NQDDLLKEKET----------LIQQLKE-ELQEKNVTLDV-QIQHVVEGKRALSELTQGV 1116
Q +L + + LIQ ++ E + KN ++ Q+QH + +L G
Sbjct: 1249 LQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK 1308
Query: 1117 TCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTK 1176
+ ++L Q EC ++K E +L + S +L+ E L+E ++ LQ+ +
Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRASKSE--VLSESSELLQQE--LEELRKSLQEKDATIR 1364
Query: 1177 DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKA 1236
L +L + I + +L+ +E E E ++LKE+ +
Sbjct: 1365 TLQENNHRLSDSIAATS----------ELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDL 1414
Query: 1237 DLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDM 1296
++ K + E T+ + + +++ V+ +++ +L + I +L+ + + +
Sbjct: 1415 LIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRG 1474
Query: 1297 KQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLE 1356
K+ Q L+E N K +++ E C + K E + L+E+EQ
Sbjct: 1475 KETEYQALQE--TNMKFSMMLREKEFECHSMKEKALAFEQL---LKEKEQ---------- 1519
Query: 1357 AKLEEVERLATELEKWKEKCNDLETKNNQ---RSNKEHENNTDVLGKLTNLQDELQESEQ 1413
K E+ +L ++ +EK + + +Q ++ NT + ++ L+D+ S Q
Sbjct: 1520 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
Query: 1414 KYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDS 1473
+ R LE + +A AE+ K KK E+ N ME + Q + +
Sbjct: 1580 ELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVE 1639
Query: 1474 DLQ-------KWREERDQLVAALEIQLK--ALISSNVQK-------------DNEIEQLK 1511
LQ K R+E ++ + Q+K AL +N+Q E+E+ K
Sbjct: 1640 SLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQK 1699
Query: 1512 RIISETSK----IETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIED 1558
++I+E K +E +++ ++ + + A+ L+ ++ +IE+
Sbjct: 1700 QLIAEWKKNAENLEGKVISLQ-ECLDEANAALDSASRLTEQLDVKEEQIEE 1749
Score = 139 bits (350), Expect = 2e-32
Identities = 276/1397 (19%), Positives = 582/1397 (41%), Gaps = 177/1397 (12%)
Query: 475 IAQKVCVPDTLNSSQE---KLFGPVKS-----SQDVSLDSNSNSKILNV--KRATISWEN 524
IAQ T NS Q KL +K SQ++ + S + N ++ T
Sbjct: 194 IAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRR 253
Query: 525 SLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAF--------ISHEEKRKL 576
E+L + E+ +EELEN Q + +++ DL K E K S ++ +L
Sbjct: 254 HREELSDYEERIEELENL--LQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQL 311
Query: 577 LDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQRE-------------ADFKET 623
D I+D+ KKL + + ++ L + +E++ E Q + E +T
Sbjct: 312 EDKIKDINKKLSSAENDRDILR-REQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDT 370
Query: 624 LLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAE 683
+ ++ IL ++A +F+ D E + + + + + A LK
Sbjct: 371 MTEKERILAQSASVE-EVFRLQQALSDAENEIMR---LSSLNQDNSLAEDNLKLKMRIEV 426
Query: 684 LAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTIN-- 741
L K K L + KEEL+ + ++ + ++++ + I+ + + +L ++ KE +N
Sbjct: 427 LEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQS 486
Query: 742 --EFQNLKSHMENTFKCNDKADTSSLIINNKLI--CNETVEVPKDSKSKICSERKRVNEN 797
E + L + +E + N +A ++I ++L NE + K + E+KRV +
Sbjct: 487 ISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRV--H 544
Query: 798 ELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENE 857
+L+ D+ K D +K + ++ +A + D+ + ++ +E++
Sbjct: 545 QLEDDKMDITK---------ELDVQKEKLIQSEVA-LNDLHLTKQK----------LEDK 584
Query: 858 LKNEKEEKAELNKQIVHFQQELSLS-EKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 916
++N + +LNK QE ++S +K+NL L + ++ Q+ +++ + +S NQ+
Sbjct: 585 VENLVD---QLNK-----SQESNVSIQKENLELKEHIR--QNEEELSRIRNELMQSLNQD 634
Query: 917 QEEKIM-KLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNG 975
L E E R++ N+S+++ ++ + ++ V + +L D+ +
Sbjct: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF--DVKMENEKLVLACEDVRHQ 692
Query: 976 SEEDNLPNTQLDLLGNDYLVSKQV------------KEYRIQEPNR--------ENSFHS 1015
EE N QL L N + + ++ K+ ++E N+ N+ +
Sbjct: 693 LEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNL 752
Query: 1016 SIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLK 1075
+ A+ E + ++K + KK +I EL++ IE++ + K KD + E E K L+
Sbjct: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLE-EQKQLTQLIN 811
Query: 1076 EKETLIQQLKEELQEKNVTLDVQIQHVVEG---KRALSELTQGVTCYKAKIKELETILET 1132
+KE I++LKE + LD Q + + ++ + E + + K + L+ LE
Sbjct: 812 KKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELER 871
Query: 1133 QKVECSHSAKL-EQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQ 1191
+ E S +A + + L+ + + L +EHL++ +K+ + + + + K Q
Sbjct: 872 LREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSK---MQ 928
Query: 1192 LTNNLQDM-KHLLQLKEEEEETNRQETE---KLKEELSASSARTQNLKADLQRKEED-YA 1246
L +LQ+ K + + + + E+ N T+ + EE+ + + +K L + +D
Sbjct: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQT 988
Query: 1247 DLKEKLTDAKKQIKQVQK-----EVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTI 1301
D + + K Q ++ ++S E + IK ELE K + + + ++
Sbjct: 989 DNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLN-EKNISLTKQID 1047
Query: 1302 QQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQ---VEQDQ---VL 1355
Q K+++ K+ + IQQ + + L+ + + + Q+Q Q +E+++ VL
Sbjct: 1048 QLSKDEVG--KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVL 1105
Query: 1356 EAKLEEVERLATELEKWKE-------KCNDLETKNNQRSNKEHENNTDVLGK-LTNLQDE 1407
K E L TE K + L+ +N + S + + D+ + + NL
Sbjct: 1106 NEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI 1165
Query: 1408 LQESEQKYNADRKKWLEEKMMLITQA--KEAENIRNKEMKKYAEDRERFFKQQNEMEILT 1465
++E + + +A +K +L T + EA + + + ++ ++R++ +Q +ME
Sbjct: 1166 IREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWK 1225
Query: 1466 AQLTEKDSDLQ----KWREERDQLVA----------ALEIQLKALISSNVQKDNEIEQLK 1511
Q+ ++Q + +EE QL A L++ LI S Q + +++
Sbjct: 1226 QQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFG 1285
Query: 1512 RIISETSKIETQIMDIKPKRISSAD--PDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVS 1569
+ +++ Q+ + K + D +L + L T + V+ +S E+
Sbjct: 1286 QELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELL 1345
Query: 1570 TENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCE 1629
+ + R E + LQ N + ++ +RK +E + +K
Sbjct: 1346 QQELEELRKSLQEKDATIRTLQENNHRLSD-------SIAATSELERKEHEQTDSEIKQL 1398
Query: 1630 NKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGT 1689
+K + LK D K +Q + SS + ++ + + + T KE
Sbjct: 1399 KEKQDVLQKLLK---EKDLLIKAKSDQLL----SSNENFTNKVNENELLRQAVTNLKERI 1451
Query: 1690 LQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPI 1749
L L+ L+ + +KI+ET + + N+ + K +
Sbjct: 1452 L-----ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECH----- 1501
Query: 1750 DISGQVILMDQKMKESD 1766
+ + + +Q +KE +
Sbjct: 1502 SMKEKALAFEQLLKEKE 1518
Score = 119 bits (298), Expect = 3e-26
Identities = 264/1262 (20%), Positives = 536/1262 (42%), Gaps = 211/1262 (16%)
Query: 356 TVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLR---ETGNINTSLLTLGK 412
T+++LQIE E ++ + E + D+ +++ +N+ + LR E N+ + + +
Sbjct: 293 TIQVLQIEKVESTKKMEQLEDKIKDI--NKKLSSAENDRDILRREQEQLNVEKRQI-MEE 349
Query: 413 CINV-----------LKNSEKSKFQQHVPFRESKLTHYF---QSFFNGKGKICMIVNISQ 458
C N+ +K S+ ++ + + + + F Q+ + + +I + +++Q
Sbjct: 350 CENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQ 409
Query: 459 CYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKL----------FGPVKSS--QDVSLDS 506
++ L + + +K L+ +E+L + +KS+ +D+SLDS
Sbjct: 410 DNSLAEDNLKLKMRIEVLEKE--KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDS 467
Query: 507 NSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETK---LLDEDLDKTLEE 563
+ LN++ S+ E E L+ E+E + TK L+ + L K E
Sbjct: 468 ELHDLRLNLEAKEQELNQSIS---EKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 524
Query: 564 NKAFISHEEKRKLLDLIEDLKKKL--INEKKEKLTLEFKIREEVTQEFTQYWAQREADFK 621
+ IS KL + D KK++ + + K +T E +++E +
Sbjct: 525 GDSIIS-----KLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQ------------S 567
Query: 622 ETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIK 681
E L + + ++ E ++ ++LV + + +E+ I +E +E E + ++I+
Sbjct: 568 EVALNDLHLTKQKLEDKV---ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR 624
Query: 682 AELAKTKGELIKTKEE---LKKRENESDSLIQELETSNKKIITQNQRIKEL-INIIDQKE 737
EL ++ + + + LK+RE E +L Q L ++ N+ +K++ ++ + E
Sbjct: 625 NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLS----ELEQLNENLKKVAFDVKMENE 680
Query: 738 DTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPK-DSKSKICSERKRVNE 796
+ ++++ +E N++ N ++ ET+++ K + ++++C +KR+ E
Sbjct: 681 KLVLACEDVRHQLEECLAGNNQLSLEK----NTIV--ETLKMEKGEIEAELCWAKKRLLE 734
Query: 797 NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIED---IRVLQENNEGLRAFLLT 853
+ ++ E+ + + + ++E I++ Q+ + +
Sbjct: 735 EANKYEKT-------------IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 854 IENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSK 913
IE + KE K L+ SL E+K LT Q+ + +I I +L + SK
Sbjct: 782 IEQMDTDHKETKDVLSS---------SLEEQKQLT------QLINKKEIFIEKLKERSSK 826
Query: 914 NQEQEEKIMK-------LSNEIETATRSITNNVSQIKLMHTKIDELR------------- 953
QE+ +K + L IE RS+ + + + +++ LR
Sbjct: 827 LQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPK 886
Query: 954 TLDSVSQISNIDLLNLRDLSNGSEED---------NLPNTQLDLLGNDYLVSKQVKEYRI 1004
TLDSV+++++ ++ L + EE+ + +++ LL + K++ E+R
Sbjct: 887 TLDSVTELAS-EVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRY 945
Query: 1005 QEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIE-ELEQQIEKLQAEVKGYKDENN--R 1061
Q + N+ H+ + + E E +K+ K QI+ +L ++ + +Q + E
Sbjct: 946 QH-EQMNATHTQL---FLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQS 1001
Query: 1062 LKEKEHKNQDDLLK-EKETLIQQLKEE------LQEKNVTLDVQIQHVVEGKRALSELTQ 1114
L + + DL K E E L++ +KE L EKN++L QI + K + +LTQ
Sbjct: 1002 LNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQL--SKDEVGKLTQ 1059
Query: 1115 GVTCYKAKIKELETILE----TQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQD 1170
+ +I+ L + TQ V +L+ +E+E + L +E HL+
Sbjct: 1060 IIQQKDLEIQALHARISSTSHTQDVVYLQQ-QLQAYAMEREKVFAVLNEKTRE-NSHLKT 1117
Query: 1171 SVKNTKDLNVKE----LKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSA 1226
D+ + +KL++E +L+ + + +E + +R EK E+ A
Sbjct: 1118 EYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDM-FRETIQNLSRIIREK-DIEIDA 1175
Query: 1227 SSARTQNLKADLQRKEEDY------ADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKI 1280
S + Q L A LQ ++ E+L + ++KQ +V M + + + +
Sbjct: 1176 LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ---QVKKMEEWKQQVMTTV 1232
Query: 1281 NELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE----AIQQYERACKDLNVKEKIIED 1336
++ + Q +EL Q Q L + NN K++ IQ YE+ +
Sbjct: 1233 QNMQHESAQLQEELHQLQA--QVLVDSDNNSKLQVDYTGLIQSYEQ------------NE 1278
Query: 1337 MRMTLEEQEQTQVEQD--QVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENN 1394
++ QE QV+ Q+ K + L +L+ + + Q + +
Sbjct: 1279 TKLKNFGQELAQVQHSIGQLCNTK----DLLLGKLDIISPQLSSASLLTPQSAECLRASK 1334
Query: 1395 TDVLGKLTNL-QDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRER 1453
++VL + + L Q EL+E +K L+EK I +E N R + + ER
Sbjct: 1335 SEVLSESSELLQQELEEL--------RKSLQEKDATIRTLQE-NNHRLSDSIAATSELER 1385
Query: 1454 FFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRI 1513
+Q + EI QL EK LQK +E+D L+ A QL + + K NE E L++
Sbjct: 1386 KEHEQTDSEI--KQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQA 1443
Query: 1514 IS 1515
++
Sbjct: 1444 VT 1445
Score = 97.1 bits (240), Expect = 1e-19
Identities = 286/1407 (20%), Positives = 548/1407 (38%), Gaps = 275/1407 (19%)
Query: 181 DSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQ---IKEVTVHNDSDDTLY 237
DS+ +L +N + R + + KE K L++ + ++ + +
Sbjct: 526 DSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585
Query: 238 GSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKR 297
+L + LN S+ ES ++ NL + I+ + I NE + L +S F+
Sbjct: 586 ENLVDQLNKSQ--ESNVSIQKENLELKEHIRQNE-EELSRIRNELMQSLNQDSNSNFKDT 642
Query: 298 KMLRLSQDVKGYSF-IKDLQWIQVSDSKEAYRLL----KL-----GIKHQSVAFTKLNNA 347
+ +V+ + +L+ + + K A+ + KL ++HQ NN
Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ 702
Query: 348 SSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSL 407
S + V+ L++E E+ +EL E K + E L N+NTS
Sbjct: 703 LSLEKNTI-VETLKMEKGEIE-----AELCWAKKRLLEEANKYEKTIEELSNARNLNTSA 756
Query: 408 LTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETL 467
L L ++ K Q ++L NI Q + ET
Sbjct: 757 LQL-------EHEHLIKLNQKKDMEIAELKK----------------NIEQMDTDHKETK 793
Query: 468 NVLKFSAIAQKVCVPDTLNSSQ---EKLFGPVKSSQDVSLDSNSNSKILN-VKRATISWE 523
+VL S QK + +N + EKL Q+ LD S + N + R TI +
Sbjct: 794 DVLSSSLEEQKQ-LTQLINKKEIFIEKLKERSSKLQE-ELDKYSQALRKNEILRQTIEEK 851
Query: 524 NSLEDLMEDED--LVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEE--KRKLLDL 579
+ M++E+ L EELE E Q+ + D ++ E + +S K L +
Sbjct: 852 DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEE 911
Query: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQ--EFTQYWAQREADFKETLLQEREILEENAER 637
I+ +K + ++ + K+ L ++E+ + EF Q A + L++ E ++ +
Sbjct: 912 IKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKT 971
Query: 638 RLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEE 697
I L E +DI +T+ + E K + E K +L K + E
Sbjct: 972 IEQIKTQL-------HEERQDI-----QTDNSDIFQETKVQSLNIENGSEKHDLSKAETE 1019
Query: 698 -----LKKRENESDSLIQELETSNKKIITQ--NQRIKELINIIDQKEDTINEFQNLKSHM 750
+K+RE E L+ E S K I Q + +L II QK+ E Q L + +
Sbjct: 1020 RLVKGIKERELEI-KLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKD---LEIQALHARI 1075
Query: 751 ENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVN-----ENELQQDEPP 805
+T D + + + ++ + +E+ R N E D
Sbjct: 1076 SSTSHTQDVVYLQQQL--------QAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVA 1127
Query: 806 AKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEK 865
AK+ ++ +D+ K R + G F TI+N + +E+
Sbjct: 1128 AKEAAL----IKLQDENKKLSTR-------------FESSGQDMFRETIQNLSRIIREKD 1170
Query: 866 AELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLS 925
E++ Q L++ + + E + SN EL ++ K ++Q +K+ +
Sbjct: 1171 IEIDALSQKCQTLLAVLQTSST--GNEAGGVNSNQ---FEELLQERDKLKQQVKKMEEWK 1225
Query: 926 NEIETATRSITNNVSQIKLMHTKIDELRTLDSVS----QISNIDLL-----NLRDLSNGS 976
++ T +++ + +Q++ ++ +DS + Q+ L+ N L N
Sbjct: 1226 QQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFG 1285
Query: 977 EE--------DNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIV 1028
+E L NT+ LLG ++S Q+ + P +S + E E++
Sbjct: 1286 QELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELL 1345
Query: 1029 KASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKE----------KEHKNQDD------ 1072
+ ++EEL + +++ A ++ ++ N+RL + KEH+ D
Sbjct: 1346 Q------QELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1399
Query: 1073 --------LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQG--------- 1115
LLKEK+ LI+ ++L N ++ ++A++ L +
Sbjct: 1400 EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
Query: 1116 ---------VTCYKAKIKELETILET----------QKVECSHSAK-----LEQDILEKE 1151
V Y+ K E + + ET ++ EC HS K EQ + EKE
Sbjct: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC-HSMKEKALAFEQLLKEKE 1518
Query: 1152 --------------------SIILKLERN-----LKEFQEH---LQDSVKNTKDLNVKEL 1183
+++ + ER+ LK+ Q LQ+ V+ +D KE
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD---KEF 1575
Query: 1184 KLKEEITQLTNNLQDMKHLLQLK----EEEEETNRQETEKLKEELSASSARTQNLKADLQ 1239
+ +E+ +L N+L + + + E+ E R++ L+E+L +SS +N
Sbjct: 1576 RSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQAS 1635
Query: 1240 RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELE--------KKKNQCS 1291
+ E L+E+L KQ + ++SV +++ K + + L+ ++K S
Sbjct: 1636 VQVES---LQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYS 1692
Query: 1292 QELDMKQRTIQQLKEQLNN------------QKVEEAIQQYERACKDLNVKEKIIEDMRM 1339
EL+ +++ I + K+ N + A+ R + L+VKE+ IE+++
Sbjct: 1693 AELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK- 1751
Query: 1340 TLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKE-KCNDLETKN------NQRSNKEHE 1392
Q+++ + L++V++ L E K + + +N + N+ HE
Sbjct: 1752 ----------RQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHE 1801
Query: 1393 NNTDVLGKLTNLQDELQESEQKYNADR 1419
++G + ++ E E EQ ++ D+
Sbjct: 1802 -VLRLMGSILGVRRE--EMEQLFHDDQ 1825
Score = 94.4 bits (233), Expect = 9e-19
Identities = 145/756 (19%), Positives = 333/756 (44%), Gaps = 124/756 (16%)
Query: 1037 QIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQD--------DLLKE-KETLIQQLKEE 1087
+I L ++ +L++EV ++ K + N D +++KE K+ Q++ +
Sbjct: 173 EINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDH 232
Query: 1088 LQEKNVTLDVQIQHVVE-GKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQD 1146
E +V + Q + E +R EL+ Y+ +I+ELE +L+ S +E D
Sbjct: 233 QHEMSVLQNAHQQKLTEISRRHREELSD----YEERIEELENLLQQ-----GGSGVIETD 283
Query: 1147 ILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLK 1206
+ S I ++++ ++ Q +++++ +++ QL + ++D+ L
Sbjct: 284 L----SKIYEMQKTIQVLQ--------------IEKVESTKKMEQLEDKIKDINKKLSSA 325
Query: 1207 EEEEETNRQETEKLKEELSASSARTQNLKADLQRKE-----------------------E 1243
E + + R+E E+L E +NLK + + + E
Sbjct: 326 ENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVE 385
Query: 1244 DYADLKEKLTDAKKQIKQVQ--KEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTI 1301
+ L++ L+DA+ +I ++ + + + +++ L+++I LEK+K+ SQE + Q ++
Sbjct: 386 EVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSL 445
Query: 1302 QQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQ---TQVEQDQVLEAK 1358
+L + K A +D+++ + + D+R+ LE +EQ + + + L A+
Sbjct: 446 LKLNNEYEVIK--------STATRDISLDSE-LHDLRLNLEAKEQELNQSISEKETLIAE 496
Query: 1359 LEEVERLATELEKW----KEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQK 1414
+EE++R E K K++ + + + + +K ++ D ++ L+D+ + ++
Sbjct: 497 IEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKE 556
Query: 1415 YNADRKKWLEEKMML----ITQAKEAENIRN--KEMKKYAEDRERFFKQQNEMEILTAQL 1468
+ ++K ++ ++ L +T+ K + + N ++ K E K+ E L +
Sbjct: 557 LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLE---LKEHI 613
Query: 1469 TEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIE--QLKRIISETSKIETQIMD 1526
+ + +L + R E L+ +L + + K+ E E LK+ +SE ++ +
Sbjct: 614 RQNEEELSRIRNE---LMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKK 670
Query: 1527 IKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTEND---QSTRFPKPEL 1583
+ A K++ E L + E R+++E+ + + ++S E + ++ + K E+
Sbjct: 671 V-------AFDVKMENEKLVLACEDVRHQLEE--CLAGNNQLSLEKNTIVETLKMEKGEI 721
Query: 1584 EIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEME---EDLVKCENKKN---ATPR 1637
E + K ++ ++ AR ++ ++ E L+K KK+ A +
Sbjct: 722 EAEL--CWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELK 779
Query: 1638 TNLKFPISDDRN-----SSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQK 1692
N++ +D + SS +EQK + +KK + I + + K + L K
Sbjct: 780 KNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK------EIFIEKLKERSSKLQEELDK 833
Query: 1693 FGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKE 1728
+ L+ + IL+ ++ ++ S K N +E
Sbjct: 834 YSQALRKN-EILRQTIEEKDRSLGSMKEENNHLQEE 868
Score = 56.2 bits (134), Expect = 3e-07
Identities = 109/621 (17%), Positives = 253/621 (40%), Gaps = 123/621 (19%)
Query: 1191 QLTNNLQDMKHLLQLKEEEE----ETNRQETEKLKEELSASSARTQNLKADLQRKEE-DY 1245
Q++N +DM L++ EE E ++ +E E + L + + R + L DL+ K E
Sbjct: 29 QISNFTKDM--LMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASE 86
Query: 1246 ADLKEKLTDAKKQIKQVQKEVSVMRD-----EDKLLRIK--------------------- 1279
+K++ T + Q++Q + E+S ++ +D+LL+++
Sbjct: 87 IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSF 146
Query: 1280 ---------------------------INELEKKKNQCSQELDMKQRTIQQLKEQLNNQK 1312
IN L + ++ E+ + Q K Q +
Sbjct: 147 AYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
Query: 1313 VEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERL-ATELEK 1371
+ I CK N+ +++ ++ +++ + + KL E+ R EL
Sbjct: 207 DQSEI------CKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSD 260
Query: 1372 WKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQ--ESEQKYNADRKKWLEEKMML 1429
++E+ +LE Q + E + L K+ +Q +Q + E+ + + + LE+K+
Sbjct: 261 YEERIEELENLLQQGGSGVIETD---LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKD 317
Query: 1430 ITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAAL 1489
I NK++ DR+ ++Q ++ + Q+ E+ +L+
Sbjct: 318 I----------NKKLSSAENDRDILRREQEQLNVEKRQIMEECENLK------------- 354
Query: 1490 EIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSF 1549
++ L S V++ + + + +RI+++++ +E ++ ++ + +S A+ + ++ L+
Sbjct: 355 -LECSKLQPSAVKQSDTMTEKERILAQSASVE-EVFRLQ-QALSDAENEIMRLSSLNQDN 411
Query: 1550 EISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVK 1609
++ ED + EV + K EL++ L N+ V T +++
Sbjct: 412 SLA----EDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLN-NEYEVIKSTATRDISLD 466
Query: 1610 IP--------KARKRKSNEM---------EEDLVKCENKKNATPRTNLKFPISDDRNS-- 1650
+A++++ N+ E + + +N++ +K +S +N
Sbjct: 467 SELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGD 526
Query: 1651 SVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFG-DFLQHSPSILQSKAK 1709
S+ + K + K+ + L I L +K++ + + L + L+ K +
Sbjct: 527 SIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVE 586
Query: 1710 KIIETMSSSKLSNVEASKENV 1730
+++ ++ S+ SNV KEN+
Sbjct: 587 NLVDQLNKSQESNVSIQKENL 607
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,303,780
Number of Sequences: 37866
Number of extensions: 2830187
Number of successful extensions: 43133
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 666
Number of HSP's successfully gapped in prelim test: 1471
Number of HSP's that attempted gapping in prelim test: 13526
Number of HSP's gapped (non-prelim): 11945
length of query: 1780
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1663
effective length of database: 13,817,196
effective search space: 22977996948
effective search space used: 22977996948
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.