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Search of human proteins with 109255236
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
(475 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109255236 centrosomal protein 63 isoform d [Homo sapiens] 912 0.0
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 850 0.0
gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] 828 0.0
gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] 828 0.0
gi|116812628 coiled-coil domain containing 67 [Homo sapiens] 224 2e-58
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 94 2e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 94 2e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 94 2e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 94 2e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 94 3e-19
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 92 1e-18
gi|31982906 cingulin-like 1 [Homo sapiens] 91 2e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 88 1e-17
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 87 3e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 87 3e-17
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 87 3e-17
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 87 3e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 87 4e-17
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 86 7e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 84 2e-16
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 84 2e-16
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 84 4e-16
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 83 5e-16
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 83 5e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 83 6e-16
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 82 8e-16
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 82 1e-15
gi|118498368 kinectin 1 isoform c [Homo sapiens] 81 2e-15
gi|71061468 centromere protein E [Homo sapiens] 80 3e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 80 4e-15
>gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
Length = 475
Score = 912 bits (2357), Expect = 0.0
Identities = 475/475 (100%), Positives = 475/475 (100%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY
Sbjct: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
Query: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL
Sbjct: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
Query: 421 ESLKLENRHLSEMVMKLELGLHERWGFTMLSSLVLNFGIQAIRQPQRPKVLELQV 475
ESLKLENRHLSEMVMKLELGLHERWGFTMLSSLVLNFGIQAIRQPQRPKVLELQV
Sbjct: 421 ESLKLENRHLSEMVMKLELGLHERWGFTMLSSLVLNFGIQAIRQPQRPKVLELQV 475
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 850 bits (2195), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY
Sbjct: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
Query: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL
Sbjct: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
Query: 421 ESLKLENRHLSEMVMKLELGLHE 443
ESLKLENRHLSEMVMKLELGLHE
Sbjct: 421 ESLKLENRHLSEMVMKLELGLHE 443
>gi|109255239 centrosomal protein 63 isoform b [Homo sapiens]
Length = 541
Score = 828 bits (2138), Expect = 0.0
Identities = 443/489 (90%), Positives = 443/489 (90%), Gaps = 46/489 (9%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAI----------------------------------------------SLESV 314
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 435 MKLELGLHE 443
MKLELGLHE
Sbjct: 481 MKLELGLHE 489
>gi|22095367 centrosomal protein 63 isoform a [Homo sapiens]
Length = 703
Score = 828 bits (2138), Expect = 0.0
Identities = 443/489 (90%), Positives = 443/489 (90%), Gaps = 46/489 (9%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAI----------------------------------------------SLESV 314
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 435 MKLELGLHE 443
MKLELGLHE
Sbjct: 481 MKLELGLHE 489
>gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
Length = 604
Score = 224 bits (570), Expect = 2e-58
Identities = 150/459 (32%), Positives = 258/459 (56%), Gaps = 30/459 (6%)
Query: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
Query: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
Query: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
Query: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 181 FQKQAQSYQTQLNGKKQCLE----DSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Query: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QE 295
+ + + E Q+ ++L+ ++ +A++ E+K+ LQS+++L+ +++ +L +E
Sbjct: 237 IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
Query: 296 KVKATNTQHA------VEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 349
+K Q+A +E+ L S+ +E K +EL + ++ E+ K+
Sbjct: 297 LLKIGECQNAQGNKTRLESSYLPSI--------KEPERKIKELFSVMQDQPNHEKELNKI 348
Query: 350 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
+ Q+ Q E+ ++S E M+ EIS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E
Sbjct: 349 RSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKM 408
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHERWGFT 448
+ K + ++++ EN HL M+ L+ G + FT
Sbjct: 409 LAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFT 447
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 94.4 bits (233), Expect = 2e-19
Identities = 88/434 (20%), Positives = 204/434 (47%), Gaps = 26/434 (5%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1144 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1203 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1255
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVEHKEILDQL 420
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ L++
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 421 ESLKLENRHLSEMV 434
K E ++M+
Sbjct: 1496 LEAKEELERTNKML 1509
Score = 82.4 bits (202), Expect = 8e-16
Identities = 97/419 (23%), Positives = 184/419 (43%), Gaps = 36/419 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1502 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1614
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1850
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 81.6 bits (200), Expect = 1e-15
Identities = 101/482 (20%), Positives = 205/482 (42%), Gaps = 65/482 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + +A KK E E H +E L+ E + L+++ +++ L +Q
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQM---REFRGNTKNHRED 135
+EE E +Q++ +E + ++KKL +E+ ++ KL K++ T N E+
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 136 RSEIERLT-------AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
+ + LT + I E + EK R ++ LE EQ +QAQ+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + L ++ + N+ + +I L ++DL + +
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAAR 1134
Query: 249 QQKEEKLRESEKLLEALQEE----------------KRE-----LKAALQSQENLIHEAR 287
+ E++ R+ + LEAL+ E KRE LK AL +E HEA+
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSHEAQ 1193
Query: 288 IQK---------EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAH 338
+Q+ E+L E+++ A + +++ L+ EL + + +E
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 339 NNEYKAEIKKLKEQILQGEQS---YSSALEGMKMEISHLTQELHQRD-------ITIAST 388
+ +A++++L+ + GE++ + + ++ E+ +T L++ + +AS
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 389 KGSSSDMEKRLRAEMQ-------KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL 441
D ++ L+ E + K E + DQL+ ++L + L + L
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 442 HE 443
+
Sbjct: 1374 SD 1375
Score = 72.4 bits (176), Expect = 8e-13
Identities = 89/389 (22%), Positives = 178/389 (45%), Gaps = 42/389 (10%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1021
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLE 438
A +E+ +QLE K +L + LE
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Score = 70.1 bits (170), Expect = 4e-12
Identities = 107/499 (21%), Positives = 215/499 (43%), Gaps = 80/499 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1258 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1377 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEI------ 346
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E+
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 347 --------KKLKEQILQGEQSYSSALEGMKMEISHLTQ-----ELHQRDI--------TI 385
KKL+ + E SA++G + I L + + QR++ I
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 386 ASTKGSSSDMEKRLRAE-MQKAEDKA----------VEHKEILDQLES-------LKLEN 427
+T + K L A+ MQ ED A +E +E+ ++L S L+ E
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 428 RHLSEMVMKLELGLHERWG 446
R L + +LE L E G
Sbjct: 1732 RRLEARIAQLEEELEEEQG 1750
Score = 60.1 bits (144), Expect = 4e-09
Identities = 86/358 (24%), Positives = 159/358 (44%), Gaps = 54/358 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1602 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1656
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1769
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1875
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE 351
+VK Q + ++A ++L +EL E E + M N K+++++ E
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 52.4 bits (124), Expect = 9e-07
Identities = 71/321 (22%), Positives = 141/321 (43%), Gaps = 25/321 (7%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 770 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 828
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 829 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 886
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ + K
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-------MEAHNNEYKAEIKKLKE 351
Q LE A ++L E + ++K+ M+ NN+ E K L+E
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 352 QI------LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 405
+I L E+ + L +K + + EL ++ + + S ++EK R
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISEL---EVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 406 AEDKAVEHKEILDQLESLKLE 426
A D + ++ Q+ LK++
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQ 1084
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 94.4 bits (233), Expect = 2e-19
Identities = 88/434 (20%), Positives = 204/434 (47%), Gaps = 26/434 (5%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1151 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1210 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1262
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVEHKEILDQL 420
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ L++
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 421 ESLKLENRHLSEMV 434
K E ++M+
Sbjct: 1503 LEAKEELERTNKML 1516
Score = 82.4 bits (202), Expect = 8e-16
Identities = 97/419 (23%), Positives = 184/419 (43%), Gaps = 36/419 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1509 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1621
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1857
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 81.6 bits (200), Expect = 1e-15
Identities = 101/482 (20%), Positives = 205/482 (42%), Gaps = 65/482 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + +A KK E E H +E L+ E + L+++ +++ L +Q
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQM---REFRGNTKNHRED 135
+EE E +Q++ +E + ++KKL +E+ ++ KL K++ T N E+
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 136 RSEIERLT-------AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
+ + LT + I E + EK R ++ LE EQ +QAQ+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + L ++ + N+ + +I L ++DL + +
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAAR 1141
Query: 249 QQKEEKLRESEKLLEALQEE----------------KRE-----LKAALQSQENLIHEAR 287
+ E++ R+ + LEAL+ E KRE LK AL +E HEA+
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSHEAQ 1200
Query: 288 IQK---------EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAH 338
+Q+ E+L E+++ A + +++ L+ EL + + +E
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 339 NNEYKAEIKKLKEQILQGEQS---YSSALEGMKMEISHLTQELHQRD-------ITIAST 388
+ +A++++L+ + GE++ + + ++ E+ +T L++ + +AS
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 389 KGSSSDMEKRLRAEMQ-------KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL 441
D ++ L+ E + K E + DQL+ ++L + L + L
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 442 HE 443
+
Sbjct: 1381 SD 1382
Score = 72.4 bits (176), Expect = 8e-13
Identities = 89/389 (22%), Positives = 178/389 (45%), Gaps = 42/389 (10%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1028
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLE 438
A +E+ +QLE K +L + LE
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Score = 70.1 bits (170), Expect = 4e-12
Identities = 107/499 (21%), Positives = 215/499 (43%), Gaps = 80/499 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1265 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1384 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEI------ 346
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E+
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 347 --------KKLKEQILQGEQSYSSALEGMKMEISHLTQ-----ELHQRDI--------TI 385
KKL+ + E SA++G + I L + + QR++ I
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 386 ASTKGSSSDMEKRLRAE-MQKAEDKA----------VEHKEILDQLES-------LKLEN 427
+T + K L A+ MQ ED A +E +E+ ++L S L+ E
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 428 RHLSEMVMKLELGLHERWG 446
R L + +LE L E G
Sbjct: 1739 RRLEARIAQLEEELEEEQG 1757
Score = 60.1 bits (144), Expect = 4e-09
Identities = 86/358 (24%), Positives = 159/358 (44%), Gaps = 54/358 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1609 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1663
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1776
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1882
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE 351
+VK Q + ++A ++L +EL E E + M N K+++++ E
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 52.4 bits (124), Expect = 9e-07
Identities = 71/321 (22%), Positives = 141/321 (43%), Gaps = 25/321 (7%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 777 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 835
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 836 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 893
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ + K
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-------MEAHNNEYKAEIKKLKE 351
Q LE A ++L E + ++K+ M+ NN+ E K L+E
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 352 QI------LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 405
+I L E+ + L +K + + EL ++ + + S ++EK R
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISEL---EVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 406 AEDKAVEHKEILDQLESLKLE 426
A D + ++ Q+ LK++
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQ 1091
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 94.4 bits (233), Expect = 2e-19
Identities = 88/434 (20%), Positives = 204/434 (47%), Gaps = 26/434 (5%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1151 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1210 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1262
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVEHKEILDQL 420
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ L++
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 421 ESLKLENRHLSEMV 434
K E ++M+
Sbjct: 1503 LEAKEELERTNKML 1516
Score = 82.4 bits (202), Expect = 8e-16
Identities = 97/419 (23%), Positives = 184/419 (43%), Gaps = 36/419 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1509 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1621
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1857
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 81.6 bits (200), Expect = 1e-15
Identities = 101/482 (20%), Positives = 205/482 (42%), Gaps = 65/482 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + +A KK E E H +E L+ E + L+++ +++ L +Q
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQM---REFRGNTKNHRED 135
+EE E +Q++ +E + ++KKL +E+ ++ KL K++ T N E+
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 136 RSEIERLT-------AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
+ + LT + I E + EK R ++ LE EQ +QAQ+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + L ++ + N+ + +I L ++DL + +
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAAR 1141
Query: 249 QQKEEKLRESEKLLEALQEE----------------KRE-----LKAALQSQENLIHEAR 287
+ E++ R+ + LEAL+ E KRE LK AL +E HEA+
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSHEAQ 1200
Query: 288 IQK---------EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAH 338
+Q+ E+L E+++ A + +++ L+ EL + + +E
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 339 NNEYKAEIKKLKEQILQGEQS---YSSALEGMKMEISHLTQELHQRD-------ITIAST 388
+ +A++++L+ + GE++ + + ++ E+ +T L++ + +AS
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 389 KGSSSDMEKRLRAEMQ-------KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL 441
D ++ L+ E + K E + DQL+ ++L + L + L
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 442 HE 443
+
Sbjct: 1381 SD 1382
Score = 72.4 bits (176), Expect = 8e-13
Identities = 89/389 (22%), Positives = 178/389 (45%), Gaps = 42/389 (10%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1028
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLE 438
A +E+ +QLE K +L + LE
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Score = 70.1 bits (170), Expect = 4e-12
Identities = 107/499 (21%), Positives = 215/499 (43%), Gaps = 80/499 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1265 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1384 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEI------ 346
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E+
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 347 --------KKLKEQILQGEQSYSSALEGMKMEISHLTQ-----ELHQRDI--------TI 385
KKL+ + E SA++G + I L + + QR++ I
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 386 ASTKGSSSDMEKRLRAE-MQKAEDKA----------VEHKEILDQLES-------LKLEN 427
+T + K L A+ MQ ED A +E +E+ ++L S L+ E
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 428 RHLSEMVMKLELGLHERWG 446
R L + +LE L E G
Sbjct: 1739 RRLEARIAQLEEELEEEQG 1757
Score = 58.9 bits (141), Expect = 1e-08
Identities = 85/354 (24%), Positives = 157/354 (44%), Gaps = 54/354 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1609 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1663
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1776
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1882
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIK 347
+VK Q + ++A ++L +EL E E + M N K++++
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 52.4 bits (124), Expect = 9e-07
Identities = 71/321 (22%), Positives = 141/321 (43%), Gaps = 25/321 (7%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 777 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 835
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 836 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 893
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ + K
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-------MEAHNNEYKAEIKKLKE 351
Q LE A ++L E + ++K+ M+ NN+ E K L+E
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 352 QI------LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 405
+I L E+ + L +K + + EL ++ + + S ++EK R
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISEL---EVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 406 AEDKAVEHKEILDQLESLKLE 426
A D + ++ Q+ LK++
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQ 1091
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 94.4 bits (233), Expect = 2e-19
Identities = 88/434 (20%), Positives = 204/434 (47%), Gaps = 26/434 (5%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1144 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1203 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1255
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVEHKEILDQL 420
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ L++
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 421 ESLKLENRHLSEMV 434
K E ++M+
Sbjct: 1496 LEAKEELERTNKML 1509
Score = 82.4 bits (202), Expect = 8e-16
Identities = 97/419 (23%), Positives = 184/419 (43%), Gaps = 36/419 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1502 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1614
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1850
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 81.6 bits (200), Expect = 1e-15
Identities = 101/482 (20%), Positives = 205/482 (42%), Gaps = 65/482 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + +A KK E E H +E L+ E + L+++ +++ L +Q
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQM---REFRGNTKNHRED 135
+EE E +Q++ +E + ++KKL +E+ ++ KL K++ T N E+
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 136 RSEIERLT-------AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
+ + LT + I E + EK R ++ LE EQ +QAQ+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + L ++ + N+ + +I L ++DL + +
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAAR 1134
Query: 249 QQKEEKLRESEKLLEALQEE----------------KRE-----LKAALQSQENLIHEAR 287
+ E++ R+ + LEAL+ E KRE LK AL +E HEA+
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSHEAQ 1193
Query: 288 IQK---------EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAH 338
+Q+ E+L E+++ A + +++ L+ EL + + +E
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 339 NNEYKAEIKKLKEQILQGEQS---YSSALEGMKMEISHLTQELHQRD-------ITIAST 388
+ +A++++L+ + GE++ + + ++ E+ +T L++ + +AS
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 389 KGSSSDMEKRLRAEMQ-------KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL 441
D ++ L+ E + K E + DQL+ ++L + L + L
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 442 HE 443
+
Sbjct: 1374 SD 1375
Score = 72.4 bits (176), Expect = 8e-13
Identities = 89/389 (22%), Positives = 178/389 (45%), Gaps = 42/389 (10%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1021
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLE 438
A +E+ +QLE K +L + LE
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Score = 70.1 bits (170), Expect = 4e-12
Identities = 107/499 (21%), Positives = 215/499 (43%), Gaps = 80/499 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1258 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1377 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEI------ 346
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E+
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 347 --------KKLKEQILQGEQSYSSALEGMKMEISHLTQ-----ELHQRDI--------TI 385
KKL+ + E SA++G + I L + + QR++ I
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 386 ASTKGSSSDMEKRLRAE-MQKAEDKA----------VEHKEILDQLES-------LKLEN 427
+T + K L A+ MQ ED A +E +E+ ++L S L+ E
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 428 RHLSEMVMKLELGLHERWG 446
R L + +LE L E G
Sbjct: 1732 RRLEARIAQLEEELEEEQG 1750
Score = 58.9 bits (141), Expect = 1e-08
Identities = 85/354 (24%), Positives = 157/354 (44%), Gaps = 54/354 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1602 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1656
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1769
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1875
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIK 347
+VK Q + ++A ++L +EL E E + M N K++++
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 52.4 bits (124), Expect = 9e-07
Identities = 71/321 (22%), Positives = 141/321 (43%), Gaps = 25/321 (7%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 770 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 828
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 829 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 886
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ + K
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-------MEAHNNEYKAEIKKLKE 351
Q LE A ++L E + ++K+ M+ NN+ E K L+E
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 352 QI------LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 405
+I L E+ + L +K + + EL ++ + + S ++EK R
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISEL---EVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 406 AEDKAVEHKEILDQLESLKLE 426
A D + ++ Q+ LK++
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQ 1084
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 94.0 bits (232), Expect = 3e-19
Identities = 100/426 (23%), Positives = 189/426 (44%), Gaps = 57/426 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + KK E E H LE ++ E+ + L+++ + + L +Q
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQ------MREFRGNTKNH 132
+EE E +Q++ +E + +LKKL EE IL+ KL K++ + EF N
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 133 REDRSEIERLTAK----IEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
E + +L K I + ++ EKQR ++ LE L++Q +QAQ+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + + + + N + +I L ++++L + +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMAL----KKIRELESQISELQEDLESERASR 1127
Query: 249 QQKEEKLRESEKLLEALQEEKRELKAALQSQENL----IHEARIQKEKLQEKVKATNTQH 304
+ E++ R+ + LEAL+ E + + +Q+ L E I K+ L+E+ K Q
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ- 1186
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
++ + Q +EL E+ E+ KR+ KA ++K K+ L
Sbjct: 1187 ------IQEMRQKHSQAVEELAEQLEQTKRV-------KANLEKAKQ-----------TL 1222
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE----HKEILDQL 420
E + E+++ + L Q KG S K++ A++Q+ + K E E+ D++
Sbjct: 1223 ENERGELANEVKVLLQ-------GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 421 ESLKLE 426
L++E
Sbjct: 1276 TKLQVE 1281
Score = 76.3 bits (186), Expect = 6e-14
Identities = 97/451 (21%), Positives = 195/451 (43%), Gaps = 43/451 (9%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVT------------ 71
+++EL QI + +SE R A + + E EL++L+++L+ T
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGE-ELEALKTELEDTLDSTAAQQELRS 1163
Query: 72 --HKEVGMLHQQVEE----HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK-KQMRE 124
+EV +L + +EE HE QEM ++ Q +++L E+L KR L+K KQ E
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
N + + ++ E ++K ++ + Q L Q + + E R LA++ +
Sbjct: 1224 ---NERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL--QVKFNEGERVRTELADKVTKL 1278
Query: 185 QAQLVNRKQKLESVELSSQS---EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTS 241
Q +L N L + S + L S+L+ + + + L+ ++ +
Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK 1338
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ ++ +++EE EK + L + ++K ++ + A K KLQ+ ++ +
Sbjct: 1339 NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLS 1398
Query: 302 TQHAVEAISLESVSATCKQLSQELMEKYEEL--KRMEAHNNEYKAEIKKLKEQILQGEQS 359
+H + + + + T +L QEL + +L +R A N E K +K +Q+L E++
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK---QKKFDQLLAEEKT 1455
Query: 360 YSSALEGMKMEISHLTQELHQRDITIA-------STKGSSSDMEKRLRAEMQKAEDKAVE 412
S+ + +E + +++A K + K+ R EM ED
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM---EDLMSS 1512
Query: 413 HKEILDQLESLKLENRHLSEMVMKLELGLHE 443
++ + L+ R L + V +++ L E
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEMKTQLEE 1543
Score = 72.0 bits (175), Expect = 1e-12
Identities = 100/462 (21%), Positives = 194/462 (41%), Gaps = 72/462 (15%)
Query: 22 EAELQELMKQI-----DIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVG 76
+AEL+ L KQ D+M + K + H LE + EQ+++ +++QL+ E+
Sbjct: 1492 KAELERLNKQFRTEMEDLMSS--KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDR 136
E Q M +++++L+ E+ +K +Q+RE ++ R+ R
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQ----SEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 137 S-----------EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
S +++ L A I+ + + KQ Q Q+ + E I
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
AQ ++KL+S+E +E+ L +L A + E + L + + G L
Sbjct: 1666 AQAKENEKKLKSME----AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721
Query: 246 QEQQQKEEKLRESEKLLEALQEEK-----RELKAALQ--------------SQENLIHEA 286
+E+++ E ++ + E+ LE Q R KA LQ +Q+N
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQ 1781
Query: 287 RIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI 346
+++++ + KVK + V++ S++A +++Q + E K +A + +
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 347 KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKA 406
KKLK+ +LQ + +A E ++ AST+ K+L+ ++++A
Sbjct: 1842 KKLKDVLLQVDDERRNA-------------EQYKDQADKASTR------LKQLKRQLEEA 1882
Query: 407 EDKAVE--------HKEILDQLESLKLENRHLSEMVMKLELG 440
E++A +E+ D E+ NR +S + KL G
Sbjct: 1883 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRG 1924
Score = 67.4 bits (163), Expect = 3e-11
Identities = 90/431 (20%), Positives = 177/431 (41%), Gaps = 91/431 (21%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + ++L++Q+ M A + E + R+ A+ K+ E +LK L + +D +K
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-EMDLKDLEAHIDSANKN------- 1632
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
E IKQ L+KL ++ K MRE + R+ E
Sbjct: 1633 --RDEAIKQ---------LRKLQAQM-----------KDCMRELD-------DTRASREE 1663
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLE-AQRKALAEQSEIIQ---------AQLVNR 191
+ A+ +E +K E + + Q+++++ E A+R+A E+ E+ A +
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
K++LE+ + E++ E ND + L+I D + T + + + QK
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI--------DQINTDLNLERSHAQK 1775
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLI---HEARIQ--KEKLQEKVKATNTQHAV 306
E R+ L+ + +ELK LQ E + ++A I + K+ + + + +
Sbjct: 1776 NENARQQ------LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEY---KAEIKKLKEQILQGEQSYSSA 363
+ + V T K+L L++ +E + E + ++ +K+LK Q+ + E+ A
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889
Query: 364 -----------------LEGMKMEISHLTQELHQRDITIA-----STKGSSSDMEKRLRA 401
+ M E+S L +L + D+ + KG+ ++ +
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDG 1949
Query: 402 EMQKAEDKAVE 412
+ AE K E
Sbjct: 1950 KADGAEAKPAE 1960
Score = 63.2 bits (152), Expect = 5e-10
Identities = 63/299 (21%), Positives = 140/299 (46%), Gaps = 19/299 (6%)
Query: 152 KSLDWEKQRLIYQQ----QVSSLEAQRKALAEQS-EIIQAQLV--NRKQKLESVELSSQS 204
K +W+ RL + QVS E + A E+ ++ + QL NR ++E+++ +
Sbjct: 821 KLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA 880
Query: 205 EIQHLSSKLERANDTICANELEIE-RLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLE 263
E L +L+ A +CA E+ RLT + +L + +++EE+ + + +
Sbjct: 881 EKLQLQEQLQ-AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 264 ALQEEKRELKAALQSQENLIHEARIQK-------EKLQEKVKATNTQHAVEAISLESVSA 316
+Q+ +EL+ L+ +E+ + +++K +KL+E+ Q+ A + +
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 317 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE---QSYSSALEGMKMEISH 373
+ + L E+ E+ K + N+++A I L+E++ + E Q ++ + +
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSE 432
L+ ++ + IA K + E+ L+A + + E++A + L ++ L+ + L E
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQE 1118
Score = 60.1 bits (144), Expect = 4e-09
Identities = 88/439 (20%), Positives = 175/439 (39%), Gaps = 49/439 (11%)
Query: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE-----TCLKIREQELK 62
+Q +G EA+LQEL + + EG E T L++ +
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFN----------EGERVRTELADKVTKLQVELDNVT 1286
Query: 63 SLRSQLDVTH----KEVGMLHQQVEEHEKIKQE---MTMEYKQELKKLHEELCILKRSYE 115
L SQ D K+ L Q+++ +++ QE + +LK++ +E K S+
Sbjct: 1287 GLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE----KNSFR 1342
Query: 116 KLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
+ Q ++ E + N + +I L A++ + ++K D ++ L+ +
Sbjct: 1343 E-QLEEEEEAKHNLEK------QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Query: 176 ALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVN 235
L+++ E + V KLE + Q E+ L L+ + C E + ++ +
Sbjct: 1396 GLSQRHE----EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 236 DLVGTSMTVLQEQQQKEEKLRESE-------KLLEALQEEKRELKAALQSQENLIHEARI 288
+ S +E+ + E + RE E + LE E+K EL+ + + +
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511
Query: 289 QKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKK 348
K+ + + V +E + ++L EL + R+E + KA+ ++
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 349 -LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAE 407
L+ + Q E+ + ++ + L E QR + +A+ K D+ K L A + A
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL-KDLEAHIDSAN 1630
Query: 408 DKAVEHKEILDQLESLKLE 426
E + QL L+ +
Sbjct: 1631 K---NRDEAIKQLRKLQAQ 1646
Score = 53.9 bits (128), Expect = 3e-07
Identities = 65/263 (24%), Positives = 119/263 (45%), Gaps = 34/263 (12%)
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEAR-------IQKEKLQEK 296
V ++Q E +L E E L L EK +L+ LQ++ L EA +K++L+E
Sbjct: 857 VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEI 916
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYK-------AEIKKL 349
+ E + + A K++ Q + E E+L+ E+ + + A++KKL
Sbjct: 917 CHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL 976
Query: 350 KE-QILQGEQSYSSALEGMKME------ISHLTQELHQRDITIASTKGSS----SDMEKR 398
+E QI+ +Q+ A E +E ++LT+E ++ ++A K +D+E+R
Sbjct: 977 EEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE-EEKSKSLAKLKNKHEAMITDLEER 1035
Query: 399 L-RAEMQKAEDKAVEHK------EILDQLESLKLENRHLSEMVMKLELGLHERWGFTMLS 451
L R E Q+ E + K ++ DQ+ L+ + L + K E L
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095
Query: 452 SLVLNFGIQAIRQPQRPKVLELQ 474
+ N ++ IR+ + ++ ELQ
Sbjct: 1096 AAQKNMALKKIRELE-SQISELQ 1117
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 91.7 bits (226), Expect = 1e-18
Identities = 108/483 (22%), Positives = 218/483 (45%), Gaps = 86/483 (17%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWE----------GRTHALETCLKIREQELKSLRSQ 67
L EAE +L + +AH+ S+++ + LE+ + + +L +L Q
Sbjct: 650 LIQIEAENSDLK----VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQ 705
Query: 68 LD---VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE 124
L+ V + + + ++E+ K E + + HE++C+ ++EK +K + +
Sbjct: 706 LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL---AFEKAKKIHLEQ 762
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQV----SSLEAQRKALAEQ 180
H+E +IERL A++E+ Q+ + EK + QQ + LE+ + L E
Sbjct: 763 -------HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTES 815
Query: 181 SEIIQAQLVNRKQKLESVELSSQSE---IQHLSSKLERANDTICANELEIERLTMRVNDL 237
++ + + + + L++++ E ++ L S LE IC E L + +N L
Sbjct: 816 KGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE-----ICK-----EELVLHLNQL 865
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLE----ALQEEKRE---LKAALQSQENLIHEARIQK 290
G ++ ++K E++ +K L+ +LQE + L+ LQ Q+ ++ + I+
Sbjct: 866 EGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYK----AEI 346
+L++ T T+ + LE ++ S E + K EE AH + K E+
Sbjct: 926 GELED----TQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIEL 981
Query: 347 KKLKEQILQGEQSYSSALEGMKMEISHLTQE-------LHQRDITIASTKGSSSDMEKRL 399
Q+ Y L M+ EI HL ++ L Q D+ + TK +++EK+
Sbjct: 982 TGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK---TELEKKT 1038
Query: 400 RA--EMQKAE-------DKAVEHKEILD--------QLESLKLENRHLSEMVMKLELGLH 442
A E++K + +A++ +E+L+ +L+S + + L +++ K +L L
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 443 ERW 445
E++
Sbjct: 1099 EKY 1101
Score = 82.8 bits (203), Expect = 6e-16
Identities = 100/444 (22%), Positives = 189/444 (42%), Gaps = 72/444 (16%)
Query: 42 EWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK 101
E E + LE L+ ++Q+ K + + +++ +E +++ E E K+E
Sbjct: 765 EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENM 824
Query: 102 KLHEELCILKR--SYEKLQKKQM---------------REFRGNT----KNHREDRSEIE 140
K E L L+ S E ++ +Q+ + GN K ++ E+
Sbjct: 825 KKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884
Query: 141 RLTAKIEEFRQKSLDWEKQRLIYQ------QQVSSLEAQRKALAEQSEI-IQAQLVNRKQ 193
L +++ + +Q +I Q QQ+ E R E ++ ++ Q+ +Q
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 944
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
+L+ SS +++ + K E A A+E +++R +V +L GT+ V E Q +E
Sbjct: 945 ELQKQRESSAEKLRKMEEKCESA-----AHEADLKR--QKVIELTGTARQVKIEMDQYKE 997
Query: 254 KLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT-QHAVEAISLE 312
+L + EK + L+ + L + ++ + + + EK VK QH+ E E
Sbjct: 998 ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTE 1057
Query: 313 SVS-----------------ATCKQLSQ----------ELMEKYEELKRMEAHNNEYKAE 345
++ +T +QL + L EKY +K + A E K E
Sbjct: 1058 ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKME 1117
Query: 346 IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 405
I+ K+++L+ +Q AL+ E+ ++ D+TI +G +L ++K
Sbjct: 1118 IEDKKQELLEMDQ----ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEK 1173
Query: 406 AEDKAVEHKEILDQLESL--KLEN 427
+E +E KE Q+ESL KL+N
Sbjct: 1174 SE---LELKECNKQIESLNDKLQN 1194
Score = 71.2 bits (173), Expect = 2e-12
Identities = 97/473 (20%), Positives = 214/473 (45%), Gaps = 54/473 (11%)
Query: 18 LTSCEAELQ-ELMKQIDIMVA--HKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKE 74
LT + E++ E MK+ + + A ++ SE + L++ L+I ++EL +QL+ ++
Sbjct: 812 LTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEK 871
Query: 75 VG-MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L ++ EE +++E+ ++ L++ E+ IL+ + ++ Q+ +E N +
Sbjct: 872 FEKQLKKKSEEVYCLQKELKIK-NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELE- 929
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ ++++E+ +K+E+ QK + ++L ++ A L Q ++I+ R+
Sbjct: 930 DTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQ-KVIELTGTARQV 988
Query: 194 KLE----SVELSS-QSEIQHL-------SSKLERANDTICANELEIERLTMRVNDLVGTS 241
K+E ELS + EI HL + L + + + + E+E+ T V +L
Sbjct: 989 KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKEL---- 1044
Query: 242 MTVLQEQQQKE--EKLRESEKLLEALQEEKRELKAALQSQENL---IHEARIQKEKLQEK 296
LQ + E E L++ E L LQ ELK+ L+ + L + +A++ E+
Sbjct: 1045 -EKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTT 1103
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEA-----------HNNEYKAE 345
+K + + +E ++ Q L E+ ELK+ A H E + +
Sbjct: 1104 IKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQK 1163
Query: 346 IKKLKEQILQGE---QSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE 402
I KL+ + + E + + +E + ++ + ++L +++ + + S ++K +
Sbjct: 1164 IIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERT 1223
Query: 403 MQKAEDK-----------AVEHKEILDQLESLKLENRHLSEMVMKLELGLHER 444
Q+ ++ A ++KE +D + L+L + +L H++
Sbjct: 1224 QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQ 1276
Score = 63.2 bits (152), Expect = 5e-10
Identities = 91/412 (22%), Positives = 176/412 (42%), Gaps = 47/412 (11%)
Query: 54 LKIREQELKSLRSQLD-VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK-KLHEELCILK 111
LKI E L+SL +L V+ E EK+ ++ + L +E +C +
Sbjct: 147 LKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKIS 206
Query: 112 RSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE 171
S QKK + ++ + EI+ L K+ + RQ++ + L
Sbjct: 207 GSSTDFQKKPRDKMFSSSAPVDQ---EIKSLREKLNKLRQQN--------------ACLV 249
Query: 172 AQRKALAEQSEIIQAQLVNRKQKLESVELSSQ--SEIQHLSSKLERANDTICANELEIER 229
Q +L + E I +L + K+ +E + Q + + L ++ + A + +
Sbjct: 250 TQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLRE 309
Query: 230 LTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL-LEALQEEKRELKAALQSQENLIHEARI 288
N L + V++++Q +E E KL ++ L++ K+ +A Q E L + +
Sbjct: 310 AE---NKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
Query: 289 QKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKK 348
K Q K K A LE V A + L + L +E KR++ YK+E++
Sbjct: 367 SKAFQQYKKKV--------AEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEI 418
Query: 349 LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKR---------L 399
LKE++ Q ++ ++ E +++ ++ + Q + S S++E + L
Sbjct: 419 LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL 478
Query: 400 RAEMQKAEDKAVEHKEILD----QLESLKLENRHLSEMVMKLELGLHERWGF 447
E ++ + + E LD ++ES ++E R L +++ +L L E +GF
Sbjct: 479 MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPL-KRELFGF 529
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/431 (20%), Positives = 190/431 (44%), Gaps = 47/431 (10%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
EL + +Q VA K + + LE L E+E K L+ + + E+ +L
Sbjct: 365 ELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILK---- 420
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCIL--KRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
EK++Q K+E E+L I+ K S Q + R+ ++ E++ EI R
Sbjct: 421 --EKLRQ-----LKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILR 473
Query: 142 ----LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
L + E + + ++ + QQ++ S + ++L E I +QL +++
Sbjct: 474 DKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL----EKIISQLPLKRELFGF 529
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRV----------------NDLVGTS 241
S+ ++ S+K +R AN+L I L +++ N L +
Sbjct: 530 KSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSL 589
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK-----EKLQEK 296
+T Q+ + E+E + + +K Q N +E Q+ E+L+ K
Sbjct: 590 ITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTK 649
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
+ +++ +++ ++ + + +EL+EK ++E+ + +++ L++Q+ +
Sbjct: 650 LIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEK 709
Query: 357 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-HKE 415
+YSS + + + L QEL +++ I S + + + +++ +KA+ +E HKE
Sbjct: 710 IVAYSS----IAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKE 765
Query: 416 ILDQLESLKLE 426
+ Q+E L+ +
Sbjct: 766 MEKQIERLEAQ 776
Score = 35.0 bits (79), Expect = 0.15
Identities = 52/276 (18%), Positives = 111/276 (40%), Gaps = 23/276 (8%)
Query: 180 QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV----- 234
+ E + A + + + +L+ E S QS + LSS N N E+L + V
Sbjct: 132 EEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHP 191
Query: 235 --------NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
++ S + Q++ +K+ S ++ + RE L+ Q +
Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQ 251
Query: 287 RIQKEKLQEKVKATNTQHAVEAISLESV---SATCKQLSQELMEKYEELKRMEAHNNEYK 343
E + TQ + LES +A+ L ++++ E+ + E +
Sbjct: 252 NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAE 311
Query: 344 AEIKKLKEQILQGEQS-YSSALEGMKMEISHLTQEL------HQRDITIASTKGSSSDME 396
++++ ++ +++ EQS S E +K+++ L Q QR+ + + + S +
Sbjct: 312 NKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQ 371
Query: 397 KRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSE 432
+ + +K E E + + L + + EN+ L E
Sbjct: 372 QYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE 407
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 91.3 bits (225), Expect = 2e-18
Identities = 96/418 (22%), Positives = 188/418 (44%), Gaps = 55/418 (13%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
+Q +K R ++ +E+ H + E Q+ E + EL+K EEL +K E+
Sbjct: 637 QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQH 696
Query: 118 QKKQMREFRGNTKNHRED-----RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA 172
Q ++R+ + ++ RSE A IEE Q D + + ++Q L
Sbjct: 697 QT-EIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755
Query: 173 QRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTM 232
+ + L ++ ++ + Q+++ ++ +E+Q L +E A + E+ R
Sbjct: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV---EVLASRSNT 812
Query: 233 RVNDLVGTSMTV--LQEQQQK--------EEKLRESEKLLEALQEEKRELKAAL------ 276
D GT M V LQE+ +K E ++ + ++ +E L+ ++ + K L
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 277 --QSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR 334
Q +E L+H + +KE + + N A + +L + KQLS++L E+ E+ ++
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQG-NLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 335 MEAHNNEYKAE-------IKKLKEQILQ-GEQSYSSALE-----------------GMKM 369
+ NE + E I+KL++++ E S +S LE M+
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 370 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ-LESLKLE 426
++ T E + +T + ME+ LR + Q+A+D+A+ +++L+Q L+ L+ E
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELR-DYQRAQDEALTKRQLLEQTLKDLEYE 1048
Score = 73.2 bits (178), Expect = 5e-13
Identities = 91/397 (22%), Positives = 185/397 (46%), Gaps = 35/397 (8%)
Query: 99 ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
E+K L E+ L +LQ++ E + N +N +E+R ER+ A +EE R + + +
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVK-NQQNIKEER---ERMRANLEELRSQHNEKVE 663
Query: 159 QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQ-SEIQHLSSKLERAN 217
+ QQ++ E + + E E+ Q ++ + + E +L Q SE+ +R+
Sbjct: 664 ENSTLQQRLEESEGELRKNLE--ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEE-KRELKAAL 276
D IE L DL +L ++++E+ LR+ E+ L AL+ K E+ +
Sbjct: 722 DR--EKGALIEELLQAKQDL----QDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHD 775
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEK--YEELKR 334
Q + L + + + L+E V+ VE ++ S ++ Q E+ K EE ++
Sbjct: 776 QEMDKLKEQYDAELQALRESVEEATKN--VEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
Query: 335 MEAHNNEYKAEIKKLKEQI--LQGEQSYS-SALEGMKMEISHLTQEL----HQRDITIAS 387
++ + E + + +L+ QI L+G+++ + L+ + EI L + L + +++
Sbjct: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
Query: 388 TKGSSSDME------KRLRAEMQKAEDKAVEHKEILDQLESLK--LENR--HLSEMVMKL 437
+ +++E + E ++ +K E E +QL LK +EN HL + + KL
Sbjct: 894 RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL 953
Query: 438 ELGLHERWGFTMLSSLVLNFGIQAIRQPQRPKVLELQ 474
+ + + + S+L L + ++ R ++ E+Q
Sbjct: 954 QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ 990
Score = 65.5 bits (158), Expect = 1e-10
Identities = 97/440 (22%), Positives = 189/440 (42%), Gaps = 66/440 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E EL++ ++++ V ++ + + L+ L EL S + D +E G
Sbjct: 672 LEESEGELRKNLEEL-FQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED---REKGA 727
Query: 78 LHQQV--------------EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMR 123
L +++ EE E + ++ E L EE+ + +KL+++
Sbjct: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
Query: 124 EFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEI 183
E + R +E T +E +S E+ + + +V L+ + + L +SE
Sbjct: 788 ELQAL-------RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE 840
Query: 184 IQ---AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTIC-ANELEIERLTMR---VND 236
++ AQL + + L+ E ++ ++ ++ + + + A + E E ++ R N+
Sbjct: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
Query: 237 L---VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
L G QEQ+Q EKL+E E+K +L+ EN EKL
Sbjct: 901 LEAAQGNLSQTTQEQKQLSEKLKEE-------SEQKEQLRRLKNEMENERWHLGKTIEKL 953
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI 353
Q+ E + S T Q +++Y+E R E + ++LKE+
Sbjct: 954 QK-----------EMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ-----RQLKEKT 997
Query: 354 LQGEQSYSSALEGMKMEISHLTQEL--HQRDITIASTK-----GSSSDMEKRLRAEMQKA 406
L+ E+S +A++ M+ E+ + +EL +QR A TK + D+E L A+
Sbjct: 998 LEAEKSRLTAMK-MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLK 1056
Query: 407 EDKAVEHKEILDQLESLKLE 426
+D++ K++ D++ L++E
Sbjct: 1057 DDRSRLVKQMEDKVSQLEME 1076
Score = 62.0 bits (149), Expect = 1e-09
Identities = 93/410 (22%), Positives = 177/410 (43%), Gaps = 76/410 (18%)
Query: 22 EAELQELMKQIDIMVAHKKS------EWEGRTHALETCLKIREQELKSLRSQLDVTHKEV 75
E + +L +QI+ + + ++EG LE L +E K S E+
Sbjct: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
Query: 76 ----GMLHQQVEEH----EKIKQEMTMEYKQELKKLHEEL----CILKRSYEKLQKKQ-- 121
G L Q +E EK+K+E E K++L++L E+ L ++ EKLQK+
Sbjct: 902 EAAQGNLSQTTQEQKQLSEKLKEES--EQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
Query: 122 -MREFRGNT---KNHREDRSEIER--LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
+ R +T +N ++ E R L + ++K+L+ EK RL + + +
Sbjct: 960 IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019
Query: 176 AL-----AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKL-ERANDTICANELEIER 229
L A+ + + QL+ + K EL ++S ++ S+L ++ D + E+E+E
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079
Query: 230 -------LTMRV-----------NDLVGTSMT--------VLQEQQQKEEKLR------- 256
L+ R+ N+L+ + E+Q K+ K R
Sbjct: 1080 ERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS 1139
Query: 257 ---ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISL-- 311
E L+ ++ EL+ L+S+E ++ +L+ KVK Q E +SL
Sbjct: 1140 YRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
Query: 312 --ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE--QILQGE 357
+ +S K + +++ E EE+ R+E+ + + E+++ + + LQG+
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ 1249
Score = 54.3 bits (129), Expect = 2e-07
Identities = 60/302 (19%), Positives = 139/302 (46%), Gaps = 20/302 (6%)
Query: 150 RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL--ESVELSSQSEIQ 207
R+ +L +EK + + + S + +A SE+ L+ +K KL E EL Q +++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV--KDLLEQKSKLTIEVAELQRQLQLE 633
Query: 208 HLSSK-LERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ 266
+ + ++ + + AN +E L + N+ V + T+ Q ++ E +LR++ + L ++
Sbjct: 634 VKNQQNIKEERERMRAN---LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 267 EEKRELKAA---LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQ 323
E+ + + LQ Q + +H+ ++ +++ K + ++A K+ +
Sbjct: 691 MEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQE 750
Query: 324 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQE---LHQ 380
+L+ K E + + A K E+ +++ + ++ Y + L+ ++ + T+ L
Sbjct: 751 DLLRKRE--RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLAS 808
Query: 381 RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHK----EILDQLESLKLENRHLSEMVMK 436
R T + + K L+ E +K + ++ E + ++ Q+E LK + E + K
Sbjct: 809 RSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKK 868
Query: 437 LE 438
E
Sbjct: 869 YE 870
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 88.2 bits (217), Expect = 1e-17
Identities = 86/395 (21%), Positives = 184/395 (46%), Gaps = 57/395 (14%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
K EWE + E KIREQE K +R Q + ++ M+ ++ EE + ++EM E ++
Sbjct: 369 KIQEWEEKIQEQEE--KIREQEEK-IREQEEKMRRQEEMMWEK-EEKMRRQEEMMWEKEE 424
Query: 99 ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
++++ E + + +L++K + + + E R E E++ + + Q++ W +
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEK--IREQEEKRQEEEKIREQEKRQEQEAKMWRQ 482
Query: 159 QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVE--------LSSQSEIQHLS 210
+ I +Q+ E + K ++ +I + + + ++K + E + Q EI
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 542
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQ 266
K+ + I E ++ R +++D ++EQ++K EEK+RE E+ + +
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHD----QEEKIREQEEKVWRQEEKIREQEEKIREQE 598
Query: 267 EEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELM 326
E+ RE + Q QE + E Q+EK+ C+Q +++
Sbjct: 599 EKIREQEEMTQEQEEKMGE---QEEKM------------------------CEQ-EEKMQ 630
Query: 327 EKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM---KMEISHLTQELHQRDI 383
E+ E+++R E E + +I++ +E+I + E+ E M + ++ +++ +++
Sbjct: 631 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 384 TIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 418
+ + + E RLR + E+K EH+E L+
Sbjct: 691 KMRRQEEKMWEQEVRLRQQ----EEKMQEHQEHLE 721
Score = 69.7 bits (169), Expect = 5e-12
Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 35/304 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 437 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 491
Query: 62 KSLRSQLDVTHKEVGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHEELCILKRSY----E 115
K +R Q + ++ +H+Q + E EK +++ M ++E + EE+ K E
Sbjct: 492 K-IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 116 KLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
K++K++ + +R K H ++ KI E +K W ++ I +Q+ + Q +
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEE--------KIREQEEKV--WRQEEKIREQE-EKIREQEE 599
Query: 176 ALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVN 235
+ EQ E+ Q Q ++ E + + ++Q K+ R + I E +I ++
Sbjct: 600 KIREQEEMTQEQEEKMGEQEEKM-CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 236 DLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKE 291
+ ++QEQ++K EEK+ E E+ ++ +E+ R + + QE + R Q+E
Sbjct: 659 E----QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL---RQQEE 711
Query: 292 KLQE 295
K+QE
Sbjct: 712 KMQE 715
Score = 65.1 bits (157), Expect = 1e-10
Identities = 89/434 (20%), Positives = 187/434 (43%), Gaps = 61/434 (14%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 163 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 222
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 223 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 282
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 283 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 341 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 379
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+ ++ QE I E R Q+E + EK + Q + E + ++ + + E
Sbjct: 380 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM----RRQEEMMWE 435
Query: 328 KYEELKRME---------AHNNEYKAEIKKLKEQILQGEQS-----YSSALEGMKMEISH 373
K E+++ +E E + E +K++EQ + EQ + + +I
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLEN---RHL 430
+++ +++ I + + +++ + EM + E+K E +EI Q E + + R
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555
Query: 431 SEMVMKLELGLHER 444
E + + E +H++
Sbjct: 556 EEKMWRQEEKMHDQ 569
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 87.4 bits (215), Expect = 3e-17
Identities = 97/400 (24%), Positives = 181/400 (45%), Gaps = 28/400 (7%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
+QEL++ R Q K+ L ++ + HE Q+M + L++L E+L KR L
Sbjct: 1165 QQELRTKREQEVAELKKA--LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 118 QKKQMREFRGNTKNHREDRSEIERLT-AKIE-EFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
+K + +G +++E E++ L K E E ++K LD + Q L +VS + R
Sbjct: 1223 EKNK----QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL--HAKVSEGDRLRV 1276
Query: 176 ALAEQSEIIQAQLVNRKQKLESVE---LSSQSEIQHLSSKLERANDTICANELEIERLTM 232
LAE++ +Q +L N LE E + + L S+L+ + + + L+
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 233 RVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK 292
R+ L ++ ++Q+++EE + EK + ALQ + + K + I K+K
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 293 LQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEEL--KRMEAHNNEYKAEIKKLK 350
L + +A + + +A++ + + T +L QEL + +L +R A N E K +K
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK---QKKF 1453
Query: 351 EQILQGEQSYSSALEGMKMEISHLTQELHQRDITIA-------STKGSSSDMEKRLRAEM 403
+Q+L E+S S+ + +E + +++A K K+LRA+M
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 404 QKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
ED ++ + L+ R L + V ++ L E
Sbjct: 1514 ---EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Score = 81.6 bits (200), Expect = 1e-15
Identities = 83/416 (19%), Positives = 179/416 (43%), Gaps = 36/416 (8%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
A++++LM K + H LE + EQ+++ +R+QL+ E+
Sbjct: 1511 ADMEDLMSS--------KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
E Q M +++++L+ E+ ++L KQ+RE ++ R+ R+ +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEAELEDERKQRA-LAVA 1617
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS 202
+ K E K L+ Q+ + R + +Q +QAQ+ + +++LE +S
Sbjct: 1618 SKKKMEIDLKDLE---------AQIEAANKARDEVIKQLRKLQAQMKDYQRELEEAR-AS 1667
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL 262
+ EI S + E+ ++ E EI +L + QE+ + +++ S
Sbjct: 1668 RDEIFAQSKESEKKLKSL---EAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 263 EALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLS 322
AL +EKR L+A + E + E + E L ++ + T Q +++++A
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ-------VDTLNAELAAER 1777
Query: 323 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 382
+ +++E N E KA++++L+ + + + + + ++ +I L ++L Q
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAV---KSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 383 ITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 438
A+ EK+L+ + ED+ + +Q+E + L + + E
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890
Score = 67.0 bits (162), Expect = 4e-11
Identities = 85/412 (20%), Positives = 180/412 (43%), Gaps = 34/412 (8%)
Query: 40 KSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEV-GMLHQQVEE--HEKIKQEMTMEY 96
K + +G T L+ + + ++ L+ QL +E+ G L + +E H+ ++ E
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 97 KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW 156
+ ++ +L E+ K S K +K++ R+ E+E L ++E+ +
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQK-----------RDLSEELEALKTELEDTLDTTAAQ 1165
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV--ELSSQSE-IQHLSSKL 213
++ R +Q+V+ L +KAL E+++ +AQ+ + +Q+ + ELS Q E + + L
Sbjct: 1166 QELRTKREQEVAEL---KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 214 ERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELK 273
E+ + E + + L V L V E + K +KL + L A E L+
Sbjct: 1223 EKNKQGL---ETDNKELACEVKVL----QQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK 333
L + + + L E+ + + A +A SLES ++L QE + L
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 334 RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 393
E K +++ +E+ + ++ + ++ +++ +++ TI S + +
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 394 DMEKRLRAEMQKAEDKAVEH-------KEILDQLESLKLENRHLSEMVMKLE 438
+ K A Q+ E+KA+ + + +L+ L ++ H ++ LE
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Score = 58.5 bits (140), Expect = 1e-08
Identities = 74/330 (22%), Positives = 144/330 (43%), Gaps = 34/330 (10%)
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQL--VNRKQKLESVELSSQSEIQHLSSKLERANDTIC 221
QQQ+S+L+ ++ A ++ Q V K K + E+Q +L + +
Sbjct: 810 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQT 869
Query: 222 ANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQEN 281
E E+E + + L+ + ++ Q + E E+E++ L +K+EL+ L E+
Sbjct: 870 KVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES 929
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNE 341
+ E + + LQ + K + A + L ++L E+ ++++
Sbjct: 930 RVEEEEERNQILQNEKK--------------KMQAHIQDLEEQLDEEEGARQKLQLEKVT 975
Query: 342 YKAEIKKLKEQILQGEQSYSSALEGMKM------EISHLTQELHQRDITIASTKGSS--- 392
+A+IKK++E+IL E S ++ K+ E S E ++ +A +
Sbjct: 976 AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035
Query: 393 -SDMEKRL------RAEMQKAEDKA-VEHKEILDQLESLKLENRHLSEMVMKLELGLHER 444
SD+E+RL R E++KA+ K E ++ DQ+ L+ + L + K E L
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA 1095
Query: 445 WGFTMLSSLVLNFGIQAIRQPQRPKVLELQ 474
+L N ++ +R+ Q ++ ELQ
Sbjct: 1096 LARGDDETLHKNNALKVVRELQ-AQIAELQ 1124
Score = 51.2 bits (121), Expect = 2e-06
Identities = 81/396 (20%), Positives = 162/396 (40%), Gaps = 64/396 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EAEL++ KQ + VA KK +E LK E ++++ D K++ L Q
Sbjct: 1602 EAELEDERKQRALAVASKKK--------MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 82 VEEHEKIKQE----------MTMEYKQELKKLHEELCILKRSYEKLQK------KQMREF 125
++++++ +E + E +++LK L E+ L+ ++ ++ E
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 126 RGNTKNHREDRS----EIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL 177
N +S E RL A+I EE ++ + E +++ ++ L
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAEL 1773
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLE-RANDTICANELEIERLTMRVND 236
A + Q N +Q+LE ++++Q L ++ + TI A E +I +L ++
Sbjct: 1774 AAERSAAQKS-DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEK 296
+ ++ E+KL+E +E + + K ++ + + + Q E+ +E+
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
N A+ ++L +EL + E N E+ LK ++ +G
Sbjct: 1893 ATRAN--------------ASRRKLQRELDDATEA-------NEGLSREVSTLKNRLRRG 1931
Query: 357 EQ-SYSSA--------LEGMKMEISHLTQELHQRDI 383
S+SS+ LEG +E+S E D+
Sbjct: 1932 GPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDV 1967
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/474 (21%), Positives = 207/474 (43%), Gaps = 60/474 (12%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQI--DIMVAHKKSEW--EGRTHALETCLKIR 57
EA+ + + GHGG + + + L++Q D+ + K+ +W E LE ++
Sbjct: 61 EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHE----KIKQEMTMEYKQELKKLHEELCILKRS 113
+QE K D + E+ L QQ+EE + IKQ + ++Q+ +L E+ +K
Sbjct: 121 QQEAKPDGLVTD-SSAELQSLEQQLEEAQTENFNIKQMKDL-FEQKAAQLATEIADIKSK 178
Query: 114 YEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ 173
Y+ +++ +RE ++ RLT ++ + D K L+ + + +
Sbjct: 179 YD--EERSLREAA---------EQKVTRLTEELNKEATVIQDL-KTELLQRPGIEDVAVL 226
Query: 174 RKALAEQSEIIQAQLVNRKQ----------KLESVELSSQSEIQHLSSKLERANDTICAN 223
+K L + ++ + R++ KL+S SS++ I L S+L + +
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLI 283
E+++L VN+L Q+ Q E L + E+ L+E+ E + ++ + +
Sbjct: 287 VQELQKLKSSVNELT-------QKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATL 339
Query: 284 HEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME---KYEELK------- 333
H+ + ++LQ ++ A+ T + L ++L +EL E KY+ LK
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 334 ----RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTK 389
E H + ++EI +L ++L+ E+ A +K + +++L ++ +A +
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 390 GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
S +E++L+ +K E+ QL+ K +++ + L E
Sbjct: 460 LKLSRLEEQLK-------EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Score = 85.5 bits (210), Expect = 1e-16
Identities = 95/448 (21%), Positives = 211/448 (47%), Gaps = 36/448 (8%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
+++ + ++ + + KSE+E + + E+ K L+ QL V + +++++
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 85 HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT----KNHREDRSEIE 140
+ ++E + + K EL + E+L I ++ K +K+ ++ +GN ++ + + +IE
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQL-IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 141 RLTA--KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA------EQSEIIQAQLVNRK 192
L KI ++ L+ + Q+ + Q L A+++ ++ E+S+ QL +
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQL-TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
ES L+++ +++ + KL A + + +N +I + +L T+ Q+ +KE
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHE-----ARIQKE--KLQEKVKATNTQHA 305
++L+E K L+ +Q+EK + L ++++ + E R +KE KL E++K+ +
Sbjct: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI 1155
Query: 306 VEAISLESVSATCKQLSQELMEKYEELK---RMEAHN-----NEYKAEIKKLKEQILQGE 357
E +L+ Q EL K + LK E N ++ K E ++LK++ ++ E
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKE 1215
Query: 358 QSYSSALE----GMKMEISH---LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA 410
S ++ GMK + LT ++ + + + K ++R+ ++ +D
Sbjct: 1216 AKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Query: 411 VEHKEILDQLESLKLENRHLSEMVMKLE 438
E + +++ + E R L E +K E
Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGE 1303
Score = 79.0 bits (193), Expect = 9e-15
Identities = 91/409 (22%), Positives = 194/409 (47%), Gaps = 45/409 (11%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
++ L ++ + + L+S+L + + +H ++ E K E T + K+EL ++ +
Sbjct: 335 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE----KGEATQKLKEELSEVETKYQH 390
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
LK +++LQ Q RE + ++ + +SEI +L +K+ E ++ L RL Q+Q+SS
Sbjct: 391 LKAEFKQLQ--QQREEK--EQHGLQLQSEINQLHSKLLE-TERQLGEAHGRLKEQRQLSS 445
Query: 170 LEAQRKALAEQSEIIQAQL-VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIE 228
K + ++ ++ QL ++R ++ ++++ +E+QH K ++ + A + +
Sbjct: 446 ----EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ---Q 498
Query: 229 RLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEA-------LQEEKRELKAALQSQEN 281
T ++ + VL++ K++K++ E LL+ L++E+ +L A +Q+ E
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNE 341
E + + LQEK Q L++ S + KQ + L ++ +E
Sbjct: 559 ---ETAVLNQ-LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE---------- 604
Query: 342 YKAEIKKLKEQILQGEQSYS---SALEGMKMEISHLTQELHQRDITIASTKGSSS----D 394
KA ++ ++++L E S + S L K ++S L ++ + + S + + + D
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 395 MEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
++ L +DK E +I QL+ + + + E +LE L E
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Score = 75.5 bits (184), Expect = 1e-13
Identities = 76/325 (23%), Positives = 148/325 (45%), Gaps = 24/325 (7%)
Query: 136 RSEIERLTAKIEEFRQKSLDWEKQRLIYQ---QQ-------VSSLEAQRKALAEQSEIIQ 185
R E++ L A ++E + S + +K+ YQ QQ V+ A+ ++L +Q E Q
Sbjct: 89 RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ 148
Query: 186 AQLVNRKQKLESVELSSQ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM 242
+ N KQ + E + +EI + SK + A E ++ RLT +N
Sbjct: 149 TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK----EA 204
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT 302
TV+Q+ K E L+ +E + K+EL +N+ E + EKL+++ K +
Sbjct: 205 TVIQDL--KTELLQRPG--IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
Query: 303 QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 362
Q+A ++ + + + QE+ +EL+++++ NE + + L E +L+ EQ Y+
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 363 ALEGMKMEI---SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 419
E E ++ LHQ+D+ + S E L + +K +++ ++
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
Query: 420 LESLKLENRHLSEMVMKLELGLHER 444
L ++ + +HL +L+ E+
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREEK 405
Score = 72.0 bits (175), Expect = 1e-12
Identities = 83/446 (18%), Positives = 186/446 (41%), Gaps = 30/446 (6%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L + +L+++++QI K E + + + E+E + L +++ E +
Sbjct: 504 LREAQNDLEQVLRQIGDK-DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L+Q E++ +++++T + ++LK E + + ++Q R +
Sbjct: 563 LNQLQEKNHTLQEQVT-QLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA----QRKALAEQSEIIQAQLVNRKQ 193
+ L +++ E ++K + Q + + S EA QR L + Q L +++Q
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681
Query: 194 KLESVELS----------SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMT 243
+L + Q L S L+ + + E + E L ++ L S+
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQ 303
V ++Q + L++ +L L+ EL L+ ++ ++ R+ +K E +++ +
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 304 HAVEAISLESVSATCKQLSQELMEKYEEL-KRMEAHNNE---YKAEIKKLKEQILQGEQS 359
+ + + + LSQE ++EEL R++ E K E + L ++ +
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 360 YSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 419
S + +K S +E + I + + +++ +L+ +M E+ E KE+
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM---ENTLKEQKELKKS 918
Query: 420 LE-------SLKLENRHLSEMVMKLE 438
LE LKLE + E +++ +
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQ 944
Score = 71.2 bits (173), Expect = 2e-12
Identities = 89/425 (20%), Positives = 184/425 (43%), Gaps = 83/425 (19%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE 86
EL+ + ++++ + + L+ ++QEL + +QLD +V Q +EH
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD----QVTAKLQDKQEHC 704
Query: 87 KIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+ EYK++ L ++ L+ +KL+ + E + + + +D + +L +
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL-EVKASKEQALQDLQQQRQLNTDL 763
Query: 147 E---EFRQKSLDWEKQ-----RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
E K L+ EK+ RL Q++ +LE+ ++ L +Q E + Q++ KQ E+
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--EKQIL--KQDFET- 818
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
LS +++IQH E L R+ TV + Q+ K EK
Sbjct: 819 -LSQETKIQH-------------------EELNNRIQT------TVTELQKVKMEK---- 848
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATC 318
EAL E +K L + + ++ + EK +K KA ++ + TC
Sbjct: 849 ----EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA----------AILDLEKTC 894
Query: 319 KQLSQELMEKYE-----------ELKRMEAHNNEYKAEIKKLKEQILQGEQSY---SSAL 364
K+L +L + E L++ + +++ K E+ ++EQ++Q + +
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954
Query: 365 EGMKMEISHLTQELHQRDITIASTKG-------SSSDMEKRLRAEMQKAEDKAVEHKEIL 417
+ ++ I+ L Q Q+ I + +G +++E +L+ ++ +A + KE +
Sbjct: 955 QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 418 DQLES 422
L++
Sbjct: 1015 SVLQN 1019
Score = 66.6 bits (161), Expect = 5e-11
Identities = 91/450 (20%), Positives = 186/450 (41%), Gaps = 64/450 (14%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
++Q LM + + + + + L++ E + LRS+L +EV + V+
Sbjct: 232 QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY---VQ 288
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
E +K+K + E Q+ + L E L ++ Y KL++K H E+ + +
Sbjct: 289 ELQKLKSSVN-ELTQKNQTLTENLLKKEQDYTKLEEK-----------HNEESVSKKNIQ 336
Query: 144 AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQA----------------- 186
A + QK LD ++ + +SL L+E+ E Q
Sbjct: 337 ATLH---QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 187 ---QLVNRKQKLESVELSSQSEIQHLSSKLERANDTICA--------NELEIERLTMRVN 235
QL ++++ E L QSEI L SKL + +L E+L +
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 236 DLVGTSMTVLQEQQQKEEKLRESEKL---LEALQEEKRELKAALQSQENLIHEARIQKE- 291
+ + + + ++Q +EK+ S +L L+ +++ +E +A QS + EA+ E
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 292 ---KLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEE-------LKRMEAHNNE 341
++ +K + A+ S E++S K+ ++L K + L +++ N+
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKE-REDLYAKIQAGEGETAVLNQLQEKNHT 572
Query: 342 YKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRA 401
+ ++ +L E++ +S+ A E + ++ L + S + S +++ +L
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
Query: 402 EMQKAEDKAVEHK---EILDQLESLKLENR 428
+K ++ K E+L E+ K R
Sbjct: 633 SKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 87.4 bits (215), Expect = 3e-17
Identities = 107/515 (20%), Positives = 225/515 (43%), Gaps = 97/515 (18%)
Query: 21 CEAELQELMKQIDIMV-AH--------------KKSEWEGRTHALETCLKIR---EQELK 62
CE E + L+K +I+ AH K++E E + L LK R E+EL
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 63 SLRSQLDVTHKEV-GMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK-- 119
L+ Q D +E+ + +Q H++ + E++ +++ + L E L K
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 120 -KQMREFRGNTKNHRED----RSEIERLTAKIEEFR---------------------QKS 153
K ++E + + +N D E+++ +AK++ F+ QK
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 154 LDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS--- 210
LD E +R++ +QV+ +EAQ+K + + + + Q+ + Q+LE + +++ L+
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 211 -SKLERANDTICANE---LEIERLTMRVNDLVGTSMTVLQEQ------------QQKEEK 254
SKLE N + +E E + +++ + + +L ++ ++ E K
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESV 314
+ EK +E ++++ +E++ L+ ++ L EA+++KE ++ + + A LE
Sbjct: 949 FKNQEKKMEKVKQKAKEMQETLK-KKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 315 SATCKQLSQ-----ELMEKYEELKRMEAHNNEYKAEI----KKLKEQILQGEQSYSSALE 365
A +S E +K + E H E I KKL +Q + ++ + L+
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQ 1067
Query: 366 GMKMEISHLTQEL---------HQRDITIASTKGSSSD-----MEKRLRAEMQKAEDKAV 411
+ E++ L Q++ ++IT +G D ++++L+ + A
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 412 EHKEILDQLESLKL-------ENRHLSEMVMKLEL 439
+ ++ LE L++ EN L E +++L++
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162
Score = 84.3 bits (207), Expect = 2e-16
Identities = 99/492 (20%), Positives = 222/492 (45%), Gaps = 56/492 (11%)
Query: 5 LEGIQNR-GHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE----- 58
LE +Q R L C+ +Q +Q ++ + K++ E L+ KI++
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 59 -----QELKSLRSQLDVTHKEVGML----HQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
+L+ ++ ++ ++ GM+ +Q+ E ++K+E + + +K++ +
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI-EEFRQKSLDWEKQRLIYQQQVS 168
L+ EK ++ E ++ +L A++ E+ + E++R+ QQ++S
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 169 SL---------EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQH---------LS 210
+ ++ + +A+ ++ + +L ++Q+L + + E Q S
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR----ESEKLLE-AL 265
L+ + + L +E L ++ ++ S L++ QQ+ E R E E LE +L
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 266 QEEK---RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLS 322
QE K ++L L++++N H I + K + + +H +A+ E + +Q
Sbjct: 581 QENKNQSKDLAVHLEAEKNK-HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 323 QE---LMEKYEELKRMEAHNNE--YKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQE 377
E L EK E+ K + E ++A I+++ E+ L+ + LE + E+S + +
Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699
Query: 378 LHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL-----ESLKLENRHLSE 432
H+ + ++ K + M++ L A+M + ++ H++ +D + S++ + L +
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKN---HHQQQVDSIIKEHEVSIQRTEKALKD 756
Query: 433 MVMKLELGLHER 444
+ +LEL L ER
Sbjct: 757 QINQLELLLKER 768
Score = 72.4 bits (176), Expect = 8e-13
Identities = 88/413 (21%), Positives = 182/413 (44%), Gaps = 47/413 (11%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSL----RSQLDVTHK 73
LT AE++ K + + K + + LE EQ++KSL S+L+ +K
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
Query: 74 EVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
E Q + E E + +M K+E++ L ++L + S L + E+ KN
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE----EYETKFKNQE 953
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL---AEQSEIIQAQLVN 190
+ ++++ +++E +K L ++ +L + + ++LE +K A+ E+ QA
Sbjct: 954 KKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 191 RKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQ 250
+ +E + + +I+ L+ E+ R +ND++ L +Q +
Sbjct: 1014 ISDAVSRLETNQKEQIESLT---------------EVHR--RELNDVISIWEKKLNQQAE 1056
Query: 251 KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIS 310
+ +++ E +Q +++E + A Q+ L+ +KE++ +++ + + +
Sbjct: 1057 ELQEIHE-------IQLQEKEQEVAELKQKILLFGC--EKEEMNKEITWLKEEGVKQDTT 1107
Query: 311 LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI-KKLKEQILQGEQ--SYSSALEGM 367
L + KQ S + ++ +++AH + + ++ K LKE EQ E
Sbjct: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167
Query: 368 KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
K ++S LT +L D S K S K L EDK++E K++ ++L
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL-------EDKSLEFKKLSEEL 1213
Score = 68.2 bits (165), Expect = 2e-11
Identities = 108/482 (22%), Positives = 211/482 (43%), Gaps = 94/482 (19%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHAL------ETCLKIREQELKSLRSQLDVT 71
L+ +LQE +++ I+ KS ++ L + EQE + + T
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 72 HKE-VGMLHQQVEEHEKIKQ--------------EMTMEYKQELKKL-------HEELCI 109
++E + +L + + E EK+ Q EM +Y++ L KL HE+ +
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSM 1793
Query: 110 LKRSYEKLQKKQMR---------EFRGNTKNHREDRSEIER-------------LTAKIE 147
+ E+L++K + E G KN+ + + +E LT +I
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGG-KNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852
Query: 148 EFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQA--QLVNRKQKLESVELSSQSE 205
E + K LD L+ Q++V +E + L + E +QA Q+ R + E +E +++ +
Sbjct: 1853 EQKIKELD---SCLVRQKEVHRVEMEE--LTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907
Query: 206 IQH-------LSSKLERANDT---ICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKL 255
+ LS+ + ND + E E ++L + L + +E QQ+ E L
Sbjct: 1908 SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL 1967
Query: 256 RES--EKLLEALQEEKRELKAALQSQ-ENLIHEARIQ----KEKLQEKVKAT-NTQHAVE 307
++ ++ E +++E+ +L+ S + L+ E Q +++L+ +K T N VE
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027
Query: 308 AISLESVSATCKQLSQELMEKYEELKR--------MEAHNNEYKAEIKKLKEQILQGEQS 359
A LES QL +++ EK ++LKR ++A E A+++ L+ Q+ + ++
Sbjct: 2028 AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087
Query: 360 YSSALE------GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH 413
Y LE + I L +L Q+ I+ +K E+ R ++ ED+ ++
Sbjct: 2088 YQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLK----EQEFREQIHNLEDRLKKY 2143
Query: 414 KE 415
++
Sbjct: 2144 EK 2145
Score = 66.6 bits (161), Expect = 5e-11
Identities = 97/518 (18%), Positives = 225/518 (43%), Gaps = 114/518 (22%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE---TCLKIREQELKSLRSQLDVTHKE 74
++ EA+L++L ++ + + ++ TH LE +K + +++SL ++ + KE
Sbjct: 1271 VSELEAQLRQLTEEQNTL----NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE 1326
Query: 75 VGMLHQQVEEHE----KIKQEMTMEY------KQELKKLHEELCILKRSYEKLQ------ 118
G Q E E ++K+E++ K+ELK+ E+ L + L
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386
Query: 119 ---KKQMREFRGNTKNHREDRSEI----------------ERLTA--KIEEFRQKSLDWE 157
++ K + E++ E+ E+++A +++++ K +W+
Sbjct: 1387 ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
Query: 158 KQ-------------RLIYQQQVSSLEAQRK---------ALAEQS---EIIQAQLVNRK 192
K+ L Q ++ S EA K L +Q+ + ++ ++ + K
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLT-----------MRVNDLVGTS 241
K+E E + ++E++ ++++ D I +EIE L + +LV
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ ++K+ +++E+E+ + L+ + +KA L++++ + + + +E++KA
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 302 TQHAVEAISL---------ESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEIKK--- 348
+ E+ + + ++A KQL ++ EK E+ K+ E+H +E ++++
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
Query: 349 ----LKEQILQGEQSYSSAL-------------EGMKMEISHLTQELHQRDITIASTKGS 391
L+E++ E S S L E + + Q+ ++ I++ + +
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV--LQRN 1744
Query: 392 SSDMEKRLRAEMQKAEDKAVEHKEILDQLES--LKLEN 427
++ EK L+ Q+ E+ H E+ Q + +KLE+
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEH 1782
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/478 (21%), Positives = 197/478 (41%), Gaps = 88/478 (18%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E +EL I I + E E L+ +EQE+ L+ ++ + E ++++
Sbjct: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 82 VE--EHEKIKQEMTM-EYKQELKK-------LHEELCILKRSYEKLQKKQMREFRGNTKN 131
+ + E +KQ+ T+ E +++LK+ L ++ LK EKL+ + + NT
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 132 HR----------EDRSEIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL 177
ED+ ++ LT+K+ EEF+ EK + + + + L
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 178 AEQSEI--------IQA---QLVNRKQKLESVELSSQSEIQHLSSKLERA----NDTICA 222
A Q +I ++A +L+N + LS S QH ++K++ A T+
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 223 NELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENL 282
E ++ +LT N L + + ++KE +++ + +E+L EK ALQ +
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGGN 1329
Query: 283 IHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEY 342
+A +KE + QL +EL E + M+ E
Sbjct: 1330 QQQAASEKE------------------------SCITQLKKELSENINAVTLMKEELKEK 1365
Query: 343 KAEIKKLKEQI------LQGEQSYS---SALEGM-------KMEISHLTQELHQRDITIA 386
K EI L +Q+ LQ S S +A+ + K E+ Q+L + T++
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425
Query: 387 STKGSS----SDMEKRLRAEMQKAEDKAVEHKEILDQLE-SLKLENRHLSEMVMKLEL 439
K S+ D + +KA+ + +H+ + +L+ L+L+++ E ++ L
Sbjct: 1426 KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Score = 58.2 bits (139), Expect = 2e-08
Identities = 116/530 (21%), Positives = 222/530 (41%), Gaps = 93/530 (17%)
Query: 24 ELQELMKQIDIM---VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQ 80
EL + K+ D + + KS+ E + LET LK + + L + E+ L++
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546
Query: 81 QVEEHEKIK--------------QEMTMEYKQELKKLHEELCILKRSYEKL------QKK 120
++ + + K QE+ E +K+ E++ L+ + +KK
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 121 QMREFRGNTKNHREDRSEIE-----RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
++ + K+ E+ +E AK+ E ++K+ +K I +Q +S +E + +
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA--EQKIAAIKKQLLSQMEEKEE 1664
Query: 176 ALAEQSEIIQAQLVNR-----------KQKLESVELSSQSE--IQHLSSK-------LER 215
+ +E ++L + ++KL+SVE SSQSE I S+K E
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEE 1723
Query: 216 ANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE--------KLRESEKLL----- 262
A+ C + E++++ +L + + Q+KEE + + E+L+
Sbjct: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 263 EALQEEKRELKAALQSQ-------ENLIHEARIQKEKLQEKVKA-TNTQHAVEAI--SLE 312
EA Q E + + LQ + +LI ++KE + ++A N ++ + + +L+
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843
Query: 313 SVSATCKQLSQELME------KYEELKRMEAHNNEYKAEIKKLKE-QILQGEQSYSSALE 365
TC+ L Q++ E + +E+ R+E E ++ +KL+ Q + G + LE
Sbjct: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEM--EELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 366 GMKME--ISHLTQ-------ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 416
E SHL Q E D+ G+ + +K + ++ +D + KE
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEF-KLAGAEREKQKLGKEIVRLQKDLRMLRKEH 1960
Query: 417 LDQLESLKLENRHLSEMVMKLELGLHERWGFTMLSSLVLNFGIQAIRQPQ 466
+LE LK E E +K E E + L L+ F Q ++ Q
Sbjct: 1961 QQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ 2010
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/420 (20%), Positives = 168/420 (40%), Gaps = 46/420 (10%)
Query: 30 KQIDIMVAHKKSEWEGRTHAL--ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEK 87
K+I+I+ K S E H L E K + QE K + + + + + +++ K
Sbjct: 922 KEIEILT-QKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 88 IKQEM---TMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTA 144
+K+E+ +E Q+ K+ + ++ + ++ + N K E +E+ R
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--- 1037
Query: 145 KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQS 204
E WEK+ QQ L+ + ++ E A+L + +
Sbjct: 1038 --RELNDVISIWEKK---LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNK 1092
Query: 205 EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEA 264
EI L + + + T+ + ++++ + VN L + ++ E L +S K
Sbjct: 1093 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1152
Query: 265 LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQE 324
LQE+ ELK + + + E + + E+ ++ + H SLE S K+LS+E
Sbjct: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
Query: 325 L-------MEKYEELKRMEAHNNEY------------------KAEIKKLKEQILQGEQS 359
L +K E L +EA NE + K+KE +L
Sbjct: 1213 LAIQLDICCKKTEAL--LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL----I 1266
Query: 360 YSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 419
+ + ++ ++ LT+E + +I+ + E ++++ M+ + V KE L +
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKS-MKADIESLVTEKEALQK 1325
Score = 54.7 bits (130), Expect = 2e-07
Identities = 73/405 (18%), Positives = 173/405 (42%), Gaps = 72/405 (17%)
Query: 41 SEWEGRTHALETCLKIREQELKSLRSQL----DVTHKEVGMLHQQVEEHEKIKQEMTMEY 96
S + G+ L T ++ ++E K L+ L D + + + L ++++ ++ K+ + E+
Sbjct: 151 SSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEF 210
Query: 97 KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW 156
L++ + + +L+ L K+++R N + + + +L + E F ++
Sbjct: 211 DASLEEKDQYISVLQTQVSLL-KQRLR----NGPMNVDVLKPLPQLEPQAEVFTKEE--- 262
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
+ E+ + + E ++ LE++ Q ++ + L+R
Sbjct: 263 ------------NPESDGEPVVEDGTSVKT--------LETL----QQRVKRQENLLKRC 298
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL 276
+TI +++ + LT L Q+Q +E+L+E EK+ + EK +L L
Sbjct: 299 KETIQSHKEQCTLLTSEKEAL----------QEQLDERLQELEKIKDLHMAEKTKLITQL 348
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRME 336
+ +NLI + K + ++ T +Q+ + L K EE+ ++
Sbjct: 349 RDAKNLIEQLEQDKGMV--------------------IAETKRQMHETLEMKEEEIAQLR 388
Query: 337 AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR-----DITIASTKGS 391
+ + + ++L+EQ + E++ LE + + T+E ++ D I + + +
Sbjct: 389 SRIKQMTTQGEELREQKEKSERAAFEELE-KALSTAQKTEEARRKLKAEMDEQIKTIEKT 447
Query: 392 SSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 436
S + L+ E+ + + + V+ + + + KL+ H E+ K
Sbjct: 448 SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARK 492
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 87.0 bits (214), Expect = 3e-17
Identities = 80/360 (22%), Positives = 167/360 (46%), Gaps = 27/360 (7%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV---EEHEKIK- 89
K EWE + E + KIREQE K R + + KE M Q+ E+ EK++
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 90 -QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEE 148
+EM E ++++++L E++ ++ E+ +K+Q E + +E +++ R KI E
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 427
Query: 149 FRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL-ESVELSSQSEIQ 207
+K + EK+ +Q + Q K E+ Q ++ +++K+ E E+ Q E
Sbjct: 428 QEEKIREQEKKMW---RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKM 484
Query: 208 HLSSKLERANDTICANELEI---ERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEK 260
H K+ + + + E ++ E + + ++EQ++K EEK+RE E+
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEE 544
Query: 261 LLEAL------QEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESV 314
+++ QEEK + + ++ QE I E + + +EK++ + + +
Sbjct: 545 MMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ 604
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
++ +++ E+ E++ E E + ++++ +E++ + E E M+ HL
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 78.6 bits (192), Expect = 1e-14
Identities = 83/352 (23%), Positives = 169/352 (48%), Gaps = 54/352 (15%)
Query: 24 ELQELMKQIDIMVAHKKS---EWEGRTHALETCLKIREQELK-----SLRSQLDVTHKEV 75
E +E M++++ M+ K+ E E + H E KIREQE K +R Q +E
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQE---KIREQEEKRQEEEKIREQEKRQEQEA 416
Query: 76 GMLHQQV---EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH 132
M Q+ E+ EKI+++ ++QE +K+HE+ EK+++++ R+
Sbjct: 417 KMWRQEEKIREQEEKIREQEKKMWRQE-EKIHEQ--------EKIREEEKRQ------EQ 461
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
E + E++ + E +RQK E++++ ++Q + Q + + +Q E I+ Q
Sbjct: 462 EEMWRQEEKIREQEEIWRQKEKMHEQEKI--RKQEEKVWRQEEKMHDQEEKIREQ----- 514
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
E + +I+ K+ + I E E + + +G +E+ Q++
Sbjct: 515 ---EEKMWRQEEKIREQEEKIREQEEKI----REQEEMMQEQEEKMGEQ----EEKMQEQ 563
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLE 312
EK+R E+ + +E+ RE K ++ QE I E Q+EK++E+ + Q E E
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWE---QEEKIREQEEMMQEQ---EEKMWE 617
Query: 313 SVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
C+Q +++ E+ E+++R E E + +++ +E++ + ++ +A+
Sbjct: 618 QEEKMCEQ-EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 72.0 bits (175), Expect = 1e-12
Identities = 81/395 (20%), Positives = 186/395 (47%), Gaps = 41/395 (10%)
Query: 56 IREQELKS----LRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILK 111
I ++ELK L+ +L + E + V+E ++ + + Q+ +L E L
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQ--QLQAEADHLG 271
Query: 112 RSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE 171
+ + + K + N +R ++ + E++ + E+ ++ WE++ Q+Q +
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE----WEEK---IQEQEEKIR 324
Query: 172 AQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLT 231
Q + + EQ E ++ Q +K E + + + K+ R + + E +I L
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 232 MRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKE 291
++++ ++ +++EEK +E EK+ E QE+++E +A + QE I E Q+E
Sbjct: 384 EKMHEQ--------EKIREQEEKRQEEEKIRE--QEKRQEQEAKMWRQEEKIRE---QEE 430
Query: 292 KLQEKVKATNTQ----HAVEAISLESVSATCKQL--SQELMEKYEELKRMEAHNNEYKAE 345
K++E+ K Q H E I E +++ +E + + EE+ R + +E + +
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE-K 489
Query: 346 IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE--- 402
I+K +E++ + E+ + + +I +++ +++ I + + E+++R +
Sbjct: 490 IRKQEEKVWRQEEK----MHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 403 MQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKL 437
MQ+ E+K E +E + + E ++ + + E K+
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKI 580
Score = 69.7 bits (169), Expect = 5e-12
Identities = 75/306 (24%), Positives = 143/306 (46%), Gaps = 34/306 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 430
Query: 62 KSLRSQLDVTHKEVGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHEELCILK---RSYEK 116
K +R Q ++ +H+Q + E EK +++ M ++E + EE+ K EK
Sbjct: 431 K-IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 117 LQKKQMREFRGNTKNHRED---RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ 173
++K++ + +R K H ++ R + E++ + E+ R++ +Q ++Q ++ Q
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 174 RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMR 233
+ + EQ E +Q Q R+Q+ + E + +I+ K+ + I E +I
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIRE--QEEKIREQKEKIREQEEKIWEQEEKIRE---- 603
Query: 234 VNDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ 289
++QEQ++K EEK+ E E+ ++ +E+ R + + QE + R Q
Sbjct: 604 -------QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL---RQQ 653
Query: 290 KEKLQE 295
+EK+QE
Sbjct: 654 EEKMQE 659
Score = 68.6 bits (166), Expect = 1e-11
Identities = 91/433 (21%), Positives = 188/433 (43%), Gaps = 60/433 (13%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 161
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 280 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 318
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+ ++ QE I E R Q+E + EK + Q + E + ++L + + E
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM----RRLEEMMWE 374
Query: 328 KYEELKRME---------AHNNEYKAEIKKLKEQILQGEQS-----YSSALEGMKMEISH 373
K E+++ +E E + E +K++EQ + EQ + + +I
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLEN--RHLS 431
+++ +++ I + + +++ + EM + E+K E +EI Q E + + R
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 432 EMVMKLELGLHER 444
E V + E +H++
Sbjct: 495 EKVWRQEEKMHDQ 507
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 86.7 bits (213), Expect = 4e-17
Identities = 104/446 (23%), Positives = 203/446 (45%), Gaps = 79/446 (17%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
ELQ+L +Q+ +KS+WEG+ ++LE+ L + + SL+S+L E+ + Q E
Sbjct: 1286 ELQDLQRQLS-QNQEEKSKWEGKQNSLESELMELHETMASLQSRL--RRAELQRMEAQGE 1342
Query: 84 EH--EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ K+ +T + + H + +++ + + E + R RS ++
Sbjct: 1343 RELLQAAKENLTAQVE------HLQAAVVEARAQASAAGILEE------DLRTARSALKL 1390
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV--- 198
++E R+++ Q L Q+Q AQ KAL E ++ L R++++E++
Sbjct: 1391 KNEEVESERERA-----QAL--QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ 1443
Query: 199 --ELSSQSEIQH-----LSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
EL Q E+Q LS L++ N + + +I+ L + L M V QE++QK
Sbjct: 1444 IQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV-QEREQK 1502
Query: 252 ----EEKLRESEK---------------------LLEALQEEKRELKAALQSQENLIHEA 286
E++RE EK ++E+ + + ++LK L + E L E
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 287 RIQKEKL---QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYK 343
K+ Q+ +K Q + ++L ++ ++ SQEL + ++ +E+H+
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 344 AEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEM 403
E+++ +++ +S +E ++ + HLTQ+L +RD + K +
Sbjct: 1623 RELQERDQEV----KSQREQIEELQRQKEHLTQDLERRDQELMLQK-----------ERI 1667
Query: 404 QKAEDKAVEHKEILDQ-LESLKLENR 428
Q ED+ +IL++ LE +KL R
Sbjct: 1668 QVLEDQRTRQTKILEEDLEQIKLSLR 1693
Score = 85.9 bits (211), Expect = 7e-17
Identities = 114/517 (22%), Positives = 219/517 (42%), Gaps = 78/517 (15%)
Query: 31 QIDIMVAHKKSE--WEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI 88
Q+D+ A K+ E WE TH LE L+ E+ L++ L +E + +++ E
Sbjct: 644 QVDLAEAEKRREALWEKNTH-LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702
Query: 89 KQEMTMEYKQ---ELKKLHEELCILKRSYEKL-QKKQMREFRGNT-KNHREDRSEIERLT 143
++ T + +Q E K+ E L + E L ++K E R + R+D +E +
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 144 AKIEEFRQKSL-DWEKQRLIYQQQVSSLEAQRKALAEQSEIIQA---------------- 186
+ +E + SL + ++Q + + LE Q + + + E+IQ
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 187 ---------QLVNRKQK----LESVELSSQSEIQHLSSKLERAND--------TICANEL 225
QL +Q+ LE + + + E+ L K E+ + + E
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLER 882
Query: 226 EIERLTMRVNDLVGTSMTVLQEQQQKE-------------EKLRESEKLLEALQEEKREL 272
E L MR+ + T M +Q Q+++E E +E LLE L + ++EL
Sbjct: 883 EKMELEMRLKEQQ-TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
Query: 273 KAALQSQENLIHEARIQKEKLQE--------------KVKATNTQHAVEAISLESVSATC 318
A Q E L + ++QK K QE ++K QH + +L+ S++
Sbjct: 942 ADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL 1001
Query: 319 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQEL 378
Q +L ++ E+LK ++ + +++ ++ L+ Q Y+ + ++ E + LT L
Sbjct: 1002 LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL 1061
Query: 379 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 438
+++ + + + S ++ L A Q ++ E KE+ Q+E L+ E + + E
Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Query: 439 LGLHERWGFTMLSSLVLNFGIQAIRQPQRPKVLELQV 475
L E + +S + ++A Q K +LQ+
Sbjct: 1122 AQLLEE----LEASHITEQQLRASLWAQEAKAAQLQL 1154
Score = 74.7 bits (182), Expect = 2e-13
Identities = 106/489 (21%), Positives = 203/489 (41%), Gaps = 100/489 (20%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEH 85
Q L +Q ++ VA K+ E +T L RE+E+++LR Q+ Q++E+
Sbjct: 1403 QALQEQGELKVAQGKALQENLALLTQT-LAEREEEVETLRGQI-----------QELEKQ 1450
Query: 86 EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK-KQMREFRGNTKNHREDRSEIERLTA 144
++++ +LKK ++E+ + + ++L+K + + E RE ++LT
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE-----QKLTV 1505
Query: 145 KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQS-------------EIIQAQLVNR 191
+ E+ R+ D E QR + + Q+ LE + + + Q E + +L
Sbjct: 1506 QREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN 1565
Query: 192 KQKLESV-----ELSSQSEIQ-----HLSSKLERANDTICANELEIERLTMRVNDLVGTS 241
K+E EL Q E Q HL+ LE + E++ + +++DL S
Sbjct: 1566 HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ-------ELQAQSSQIHDLESHS 1618
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ--SQENLIHEARIQ---------- 289
+ +E Q+++++++ + +E LQ +K L L+ QE ++ + RIQ
Sbjct: 1619 TVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQT 1678
Query: 290 ------------------------KEKLQEKVKATNTQHAVEAISLESVSATCKQLSQEL 325
++ +QE+ + + SLE + L
Sbjct: 1679 KILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI-------L 1731
Query: 326 MEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ----SYSSALEGMKMEISHLTQEL--- 378
+K +E++ + H +E + E+K EQ LQG S L + EI L Q+L
Sbjct: 1732 RDKEKEVECQQEHIHELQ-ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790
Query: 379 -HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKL 437
Q ++ S + + ++ L Q+ E E ++ Q E +K + L + +
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA 1850
Query: 438 ELGLHERWG 446
+ L ER G
Sbjct: 1851 HMTLKERHG 1859
Score = 73.6 bits (179), Expect = 4e-13
Identities = 88/408 (21%), Positives = 184/408 (45%), Gaps = 36/408 (8%)
Query: 55 KIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSY 114
KI E++L+ ++ L +E+ Q ++E + + + + L E + ++ R
Sbjct: 1679 KILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL----EHMKLILRDK 1734
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL---- 170
EK + Q + + +++ L K+ E E++ ++ QQQ+
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
Query: 171 EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERL 230
E + ++L Q + Q L R Q+LE++ Q E Q + ER + A + +E+
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEAL----QQEQQQAQGQEERVKEKADALQGALEQA 1850
Query: 231 TMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK 290
M + + G ++ ++ EE+L + ++AL+E +L+A + QE +
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA----- 1905
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK--RMEAHNNEYKAEIKK 348
LQ++ +H VE +L+ + Q L E+ +EL+ R E+ ++ ++ E +
Sbjct: 1906 --LQQQCAEQAQEHEVETRALQD---SWLQAQAVLKERDQELEALRAESQSSRHQEEAAR 1960
Query: 349 LKEQILQGEQSYS-SALEGMK---MEISHLTQELHQRDITIAST----KGSSSDMEKRLR 400
+ + LQ + +AL+G + +E + L++ L T+ ++ + S +E+ LR
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020
Query: 401 AEMQKAEDKAVEHKEILDQLESLKL----ENRHLSEMVMKLELGLHER 444
+ + +D+ + ++E + QL+ E RH E LE L +R
Sbjct: 2021 IQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068
Score = 70.1 bits (170), Expect = 4e-12
Identities = 94/434 (21%), Positives = 191/434 (44%), Gaps = 53/434 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L C+ + L +Q D +WE AL L+ E +L Q EV
Sbjct: 409 LAGCQEAVNLLQQQHD--------QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L ++ E +K ++E+ +Q+L+ L +E L+R +LQ Q +G + +E+
Sbjct: 461 LSKERELLQKAREEL----RQQLEVLEQEAWRLRRVNVELQL-QGDSAQGQKEEQQEELH 515
Query: 138 ----EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
E ERL + K + + + ++ + S + + L ++ + A L +Q
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 194 ---KLESVELSSQSEIQHLSS---KLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+L S E + ++E+ L + KL N+ + +++ + + +++ + + + ++
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 248 QQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENL-------IHEARIQKEKLQEK 296
+Q L+ E+EK EAL E+ L+A LQ E + + + +KE++Q+K
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQEL---MEKYEELKRMEAHNNEYKAEIKKLKEQI 353
+ + Q LE + K+ + L +++ E L R +A +++ ++ +
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 354 LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH 413
+ Q SSA E ++ + E Q++ I TKG +L ++Q +
Sbjct: 756 AEQLQGLSSAKELLESSLF----EAQQQNSVIEVTKG-------QLEVQIQ----TVTQA 800
Query: 414 KEILD-QLESLKLE 426
KE++ ++ LKLE
Sbjct: 801 KEVIQGEVRCLKLE 814
Score = 63.2 bits (152), Expect = 5e-10
Identities = 97/444 (21%), Positives = 187/444 (42%), Gaps = 46/444 (10%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGML---HQ 80
EL +L Q D+ +K+E + R L L +++ + + + V +L H
Sbjct: 266 ELIQLKSQGDL----EKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHT 321
Query: 81 QVEEHEKIKQEMTMEYKQELKKLHEELC-ILKRSYEKLQKKQMRE--------------F 125
++ EHE E K L+++ +++ ++ + + + E +
Sbjct: 322 ELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDY 381
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
+ K RS + R +++ RQ+ ++ + QQQ E + KAL ++ +
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ--- 438
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSK---LERANDTICAN----ELEIERLTMRVN--- 235
+L + L + Q E+ LS + L++A + + E E RL RVN
Sbjct: 439 -KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRL-RRVNVEL 496
Query: 236 DLVGTSMTVLQEQQQKEEKL--RESEKLLE---ALQEEKRELKAALQSQENLIHEARIQK 290
L G S +E+QQ+E L RE E+L E L+ ++ E + L + + + ++
Sbjct: 497 QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEG 556
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
E L+++ A S+ +S++ L E+ + ++ A N + L
Sbjct: 557 ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLN 616
Query: 351 EQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS-DMEKRLRAEMQKAEDK 409
+Q+LQ E+ S +ME + + Q D+ A + + + L A++QKAE+
Sbjct: 617 QQLLQLEEENQSVCS--RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 410 AVEHKEILDQLESLKLE-NRHLSE 432
E + L ++ K E + LSE
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSE 698
Score = 62.8 bits (151), Expect = 7e-10
Identities = 110/490 (22%), Positives = 211/490 (43%), Gaps = 92/490 (18%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEG-RTHALETCLKIREQELKSLRSQLDVTHKEVG 76
+ + +A+ +E Q + + + E E R LET L+ ++EL QL+ +++
Sbjct: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT-QKELADASQQLERLRQDMK 956
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKK-----------LHEELCILKRSYEKLQK------ 119
+ + +E I Q E ++ELK+ L EE L + LQK
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 120 --------------KQMREFRGNTKNHREDRSEIER----LTAKIEEFRQKSLDWEKQRL 161
++++E T+ + + E+ER LT + E Q+ L ++
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 162 IYQQQVSSL-------EAQRKALAEQSEIIQAQLVNRKQKL--ESVELSSQSEIQHLSSK 212
I QQ++S+L + ++K L+ Q E+++ ++ ++ + +L + E H++ +
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQ 1136
Query: 213 LERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE--KLLEALQ---- 266
RA ++ A E + +L +R+ + EQQ + +++ L ALQ
Sbjct: 1137 QLRA--SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALG 1194
Query: 267 ---EEKRELKAALQSQENLIHEARIQKEKLQEKVKAT-NTQHAVEAISLESVSATCKQLS 322
E + EL S ++ E Q ++ + A+S E+V++ +L
Sbjct: 1195 SVCESRPELSGGGDSAPSV-----WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 323 QEL-------------MEKYEE-LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 368
Q+L ++K EE L EA ++ E++ L+ Q+ Q ++ S EG +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE-KSKWEGKQ 1308
Query: 369 MEISHLTQELHQRDITIASTKGSSSDMEKRL-RAEMQKAEDKAVEHKEILDQL-ESLKLE 426
+ ELH+ T+AS ++ RL RAE+Q+ E A +E+L E+L +
Sbjct: 1309 NSLESELMELHE---TMAS-------LQSRLRRAELQRME--AQGERELLQAAKENLTAQ 1356
Query: 427 NRHLSEMVMK 436
HL V++
Sbjct: 1357 VEHLQAAVVE 1366
Score = 51.6 bits (122), Expect = 2e-06
Identities = 96/448 (21%), Positives = 181/448 (40%), Gaps = 54/448 (12%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEH 85
Q L++Q ++ E T L+ L + + L L + E+ + +E
Sbjct: 1982 QHLLEQAEL-----SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036
Query: 86 EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAK 145
+ Q+ + +EL+ E +L++S + ++ M + + N RE+ EI L
Sbjct: 2037 VQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREE-EEIRGLHQS 2095
Query: 146 IEEFRQKSLDWEKQRLI---YQQQVSSLEA-----QRKALAEQSEIIQAQLVNRKQKLES 197
+ E Q +L ++Q ++ QQ ++LEA + + EQS KL+S
Sbjct: 2096 VREL-QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS-----------LKLDS 2143
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
+E Q E++ L + L + A E+E + DL L + + L+E
Sbjct: 2144 LEPRLQRELERLQAALRQTE----AREIEWRE---KAQDLA----LSLAQTKASVSSLQE 2192
Query: 258 SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT----QHAVEAISLES 313
L+A E+ + LQ + L A ++KE+L AT+T + + L
Sbjct: 2193 VAMFLQASVLERDSEQQRLQDELELTRRA-LEKERLHSP-GATSTAELGSRGEQGVQLGE 2250
Query: 314 VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISH 373
VS + S + MEK +R+E H + A ++ + ++ + S LE ++ E
Sbjct: 2251 VSGVEAEPSPDGMEKQSWRQRLE-HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRK 2309
Query: 374 LTQELHQR----DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRH 429
L +E + + I+ SS + + A+ A KE++ L LE +
Sbjct: 2310 LKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQ 2369
Query: 430 LSEMVMKLE------LGLHERWGFTMLS 451
+ + + GLH ++L+
Sbjct: 2370 KQDYITRSAQTSRELAGLHHSLSHSLLA 2397
Score = 50.1 bits (118), Expect = 4e-06
Identities = 76/401 (18%), Positives = 174/401 (43%), Gaps = 57/401 (14%)
Query: 18 LTSCEAELQELMKQIDIM---VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKE 74
L +C+A ++L + + I + + ++ L+ L R++EL+ + + + K
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
Query: 75 VGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHE-----ELCILKRSYEKLQKKQMREFRG 127
+ Q+ ++E + + QE E E++ LH+ +L + ++ E L+ ++ ++ R
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEE---EIRGLHQSVRELQLTLAQKEQEILELRETQQ-RN 2120
Query: 128 NTK----NHR----EDRS------------EIERLTAKIEEFRQKSLDWEKQRLIYQQQV 167
N + +H+ E++S E+ERL A + + + ++W ++ +
Sbjct: 2121 NLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSL 2180
Query: 168 SSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEI 227
+ +A +L E + +QA ++ R E L + E+ + + ER + + E+
Sbjct: 2181 AQTKASVSSLQEVAMFLQASVLERDS--EQQRLQDELELTRRALEKERLHSPGATSTAEL 2238
Query: 228 ---ERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
+++ ++ G + +K+ + E L +A+ + + ++ LQ +
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID-RSRLQRHNVQLR 2297
Query: 285 EARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQE------------LMEKYEEL 332
Q E+ + K+K A +A SLE AT +Q+ + E +E+
Sbjct: 2298 STLEQVERERRKLK-REAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV 2356
Query: 333 KRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISH 373
++A + E K+ ++ I + Q+ S L G+ +SH
Sbjct: 2357 VLLQA---QLTLERKQKQDYITRSAQT-SRELAGLHHSLSH 2393
Score = 37.0 bits (84), Expect = 0.039
Identities = 68/306 (22%), Positives = 119/306 (38%), Gaps = 42/306 (13%)
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
E+Q L QQQ++ +A + S+ Q + +KL++ L +S Q L +LE
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEAT 80
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKREL--KA 274
I +E + + L+E+QQ+ E L E L L EK ++ KA
Sbjct: 81 GGPIPQRWENVEEPNL------DELLVRLEEEQQRCESLAEVNTQLR-LHMEKADVVNKA 133
Query: 275 ALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR 334
+ E L + +++L K + L+ L +E++
Sbjct: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
Query: 335 MEAHNN----EYKAEIKKLKEQIL-----------QGEQSYSSALEG--------MKMEI 371
M++ + E KAE +L +L E + S ++G + +
Sbjct: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
Query: 372 SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLS 431
L +E H+R + K S D+EK AE+Q D+ E +L Q + +N
Sbjct: 254 QELEKEAHERSQELIQLK-SQGDLEK---AELQ---DRVTELSALLTQSQK---QNEDYE 303
Query: 432 EMVMKL 437
+M+ L
Sbjct: 304 KMIKAL 309
Score = 33.9 bits (76), Expect = 0.33
Identities = 67/353 (18%), Positives = 135/353 (38%), Gaps = 61/353 (17%)
Query: 103 LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR------QKSLD- 155
L E++ L++ + Q R+ + + + + + + +L AK+ ++R +K L+
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 156 --------WEK-QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
WE + + + LE +++ +E + QL +K + V + + ++
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAE-VNTQLRLHMEKADVVNKALREDV 138
Query: 207 QHLSSKLERANDTICANE-----------------------LEIERLTMRVNDLVGTSMT 243
+ L+ RA D + E L E +T R + L S T
Sbjct: 139 EKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198
Query: 244 VLQEQQQKEEKLRESEKLLE-----ALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+ K E +R S LL + + RE + + + + K QE K
Sbjct: 199 DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEK 258
Query: 299 ATNTQHAVEAISLESVSATCK-QLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE 357
+ + + E I L+S K +L + E L + + N +Y+ IK L+E + E
Sbjct: 259 EAH-ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317
Query: 358 QSYSSALE--------------GMKMEISHLTQELHQRDITIASTKGSSSDME 396
+++ +E ++ I +TQ + + IA G + +E
Sbjct: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370
Score = 31.6 bits (70), Expect = 1.6
Identities = 27/133 (20%), Positives = 60/133 (45%), Gaps = 6/133 (4%)
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
+++ + E V A +Q+++ + +LK + ++KL+ ++LQ Y S
Sbjct: 15 SLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQ----YRSWC 70
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
+ ++ + + QR + + + ++ RL E Q+ E A + ++ +E
Sbjct: 71 QELEKRLEATGGPIPQRWENV--EEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKAD 128
Query: 425 LENRHLSEMVMKL 437
+ N+ L E V KL
Sbjct: 129 VVNKALREDVEKL 141
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 85.9 bits (211), Expect = 7e-17
Identities = 101/388 (26%), Positives = 178/388 (45%), Gaps = 61/388 (15%)
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK-----LHEELCILKRSYEKLQKK--QMREFRGNTK 130
L++ EEH K QE +E + +L+K L ++ C+ +++ E LQ K Q+ E +
Sbjct: 341 LNELTEEHSKATQEW-LEKQAQLEKELSAALQDKKCLEEKN-EILQGKLSQLEEHLSQLQ 398
Query: 131 -NHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR-----KALAEQSEII 184
N +++ E+ ++E +Q++ Q +V LE +R K LAE+
Sbjct: 399 DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 185 QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTV 244
+ KQ+L S+ QS I +LS E A++ RLT +V L T+
Sbjct: 459 E-----EKQQLSSLITDLQSSISNLSQAKEELEQ---ASQAHGARLTAQVASLTSELTTL 510
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ---------- 294
QQ++++L L + +E++ +L LQ QE R Q E+L
Sbjct: 511 NATIQQQDQELAG---LKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567
Query: 295 ----EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
EK +AT HA + ++ ++ L E+ LK++EA E A+++ L+
Sbjct: 568 KEVAEKQEATRQDHA------QQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQ 621
Query: 351 EQILQGEQSYSSALEGM------KMEISHLTQELHQRDITIA-----STKGSSSDMEKRL 399
+Q+ ++ SA + K E+S +EL Q + A + +++E +L
Sbjct: 622 QQLQVANEARDSAQTSVTQAQREKAELSRKVEEL-QACVETARQEQHEAQAQVAELELQL 680
Query: 400 RAEMQKAEDK---AVEHKEILDQLESLK 424
R+E QKA +K A E ++ +QL++LK
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALK 708
Score = 79.0 bits (193), Expect = 9e-15
Identities = 98/462 (21%), Positives = 193/462 (41%), Gaps = 69/462 (14%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
+K+E + L+ C++ QE ++Q+ ++ Q+ E E++ QE + ++
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD-QLQE 702
Query: 99 ELKKLHEELCILKRSYEKLQKK-------QMR-------EFRGNTKNHREDRSEIE--RL 142
+L+ L E L + K S E+ +++ Q R E R + H+ +R E+E R
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 143 TAKIEEFRQKSLDWEKQ---RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVE 199
K E R + L Q ++ ++ ++ AQ A +E ++++ R++ +S +
Sbjct: 763 GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 200 LSSQ-------------SEIQHLSSKLERANDTICA----NELEIERLTMRVNDLVGTSM 242
+Q E + +L+ A + + +EL+I R + +L
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLA 882
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QEKVKATN 301
LQ+ Q+KE + ++ L LQE+ + E L+ +A Q+E +E VK
Sbjct: 883 RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPA 942
Query: 302 TQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYS 361
+ LE +Q ++ L+ ME + E+++L+ +++ +
Sbjct: 943 RAGDRQPEWLE------EQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996
Query: 362 SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLR----------AEMQKAEDKAV 411
+ E++ LTQE + +A K + +++E RL+ A +Q+A A+
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056
Query: 412 EHKEILDQ---------------LESLKLENRHLSEMVMKLE 438
KE DQ LE L+ + L E + K E
Sbjct: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1098
Score = 78.2 bits (191), Expect = 2e-14
Identities = 103/480 (21%), Positives = 199/480 (41%), Gaps = 59/480 (12%)
Query: 8 IQNRGHGGGFLTSCEAELQELMKQI-DIMVAHKKSEWEGRTHALETCLKIRE--QELKSL 64
+ RGH + + +L I ++ A ++ E + H ++ EL +L
Sbjct: 451 LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 65 RSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE 124
+ + +E+ L QQ +E + + + +Q + L ++ L S K +++Q++E
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSL-KQKEQQLKE 569
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
+ R+D ++ +L EE R+ SL E+ + Q LEA K A + EI+
Sbjct: 570 VAEKQEATRQDHAQ--QLATAAEE-REASLR-ERDAALKQ-----LEALEKEKAAKLEIL 620
Query: 185 QAQLVNRKQKLESVELS---SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTS 241
Q QL + +S + S +Q E LS K+E + E +V +L
Sbjct: 621 QQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQ--------------EEKRELKAALQSQENLIHEAR 287
+ Q+ +KE +E ++L E LQ EEKR AL+ Q+ I E +
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
Query: 288 IQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR----MEAHNNEYK 343
+ L E+ K + E + + A +QL + + E L+R A + +
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800
Query: 344 AEIKKLKEQILQGEQSYSSA--------------LEGMKMEISHLTQELHQ--------- 380
+E ++L +++ + Y + L +K E QEL +
Sbjct: 801 SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
Query: 381 --RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 438
++ I+ + +++ L +Q+ ++K V +++ D L +L+ + S+ V +LE
Sbjct: 861 SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Score = 77.8 bits (190), Expect = 2e-14
Identities = 81/374 (21%), Positives = 168/374 (44%), Gaps = 44/374 (11%)
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK--QMREFRGNTK-NHREDR 136
+++EE + +TM + LK+ + LK ++ +K Q+ E G+ RE
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQD----LKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 137 SEIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
S +++L + EE + + +W +++ ++++S+ +K L E++EI+Q +L +
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+ L ++ + E K E D + L+ E T+ N+ T + E + E
Sbjct: 392 EHLSQLQDNPPQE------KGEVLGDVLQLETLKQEAATLAANN---TQLQARVEMLETE 442
Query: 253 EKLRESEKLLEA--LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIS 310
+E++ L E +EEK++L + + ++ I KE+L++ +A + + S
Sbjct: 443 RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
Query: 311 LES----VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEG 366
L S ++AT +Q QEL ++ K +A Q+ Q Q A +G
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQA--------------QLAQTLQQQEQASQG 548
Query: 367 MKMEISHLTQELHQRDITIAST----KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 422
++ ++ L+ L Q++ + + + D ++L ++ E E L QLE+
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA 608
Query: 423 LKLENRHLSEMVMK 436
L+ E E++ +
Sbjct: 609 LEKEKAAKLEILQQ 622
Score = 65.5 bits (158), Expect = 1e-10
Identities = 92/503 (18%), Positives = 203/503 (40%), Gaps = 78/503 (15%)
Query: 4 LLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKS 63
L E Q GH L S + EL ++ H K+E E + QE +
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQ---DHSKAEDEWKAQVARG-----RQEAER 1222
Query: 64 LRSQLDVTHKEVGMLHQQVEEHEKIKQEM---TMEYKQELKKLHEELCILK--------R 112
S + +EV +L++QV E E +E+ M ++ +KL E L +L+ R
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR 1282
Query: 113 SYEKLQ--KKQMREFRGNTKNHRED----RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ 166
+ E+ +++++ R + R R E+ + EE Q+ W+++ +Q
Sbjct: 1283 AAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQA 1342
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE 226
+S+L+ + + ++ + ++L+ K + ++ + + +LE++ E
Sbjct: 1343 LSTLQLEHTS----TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAE 1398
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
+ R + +L+ V ++++ ++ E E L K+ + L A
Sbjct: 1399 LLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA 1458
Query: 287 RIQKEKLQEKVKATNTQHAVEAISLES------------VSATCKQLSQELMEKYE---- 330
+ ++ L+ ++ ++ E ++ + +T ++L + + KYE
Sbjct: 1459 NLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL-EVMTAKYEGAKV 1517
Query: 331 ----ELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIA 386
E +R + + A++++L ++ Q EQ+ K+ S ++ Q+ +
Sbjct: 1518 KVLEERQRFQEERQKLTAQVEQL--EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
Query: 387 STKGSSSDME-KRLRAEMQKAE------DKAVEH-------------------KEILDQL 420
+G S E +RL+A++ + + ++A EH +E+ +QL
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
Query: 421 ESLKLENRHLSEMVMKLELGLHE 443
SL+ + E+ + E HE
Sbjct: 1636 RSLEQLQKENKELRAEAERLGHE 1658
Score = 64.7 bits (156), Expect = 2e-10
Identities = 91/415 (21%), Positives = 168/415 (40%), Gaps = 42/415 (10%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
++L+E + Q+ +K E G LET +QE +L + V ML +
Sbjct: 388 SQLEEHLSQLQDNPPQEKGEVLGDVLQLETL----KQEAATLAANNTQLQARVEMLETER 443
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIE-- 140
+ E +++E ++L + L+ S L + K E S+
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ---------AKEELEQASQAHGA 494
Query: 141 RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVEL 200
RLTA++ SL E L + + + L +Q++ QAQL Q+ E
Sbjct: 495 RLTAQVA-----SLTSELTTL--NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
Query: 201 SSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE- 259
+ +++ LSS L++ + E+ ++ R + + + +++E LRE +
Sbjct: 548 GLRHQVEQLSSSLKQKEQQL--KEVAEKQEATRQDH----AQQLATAAEEREASLRERDA 601
Query: 260 --KLLEALQEEKRELKAALQSQENLIHEAR---------IQKEKLQEKVKATNTQHAVEA 308
K LEAL++EK LQ Q + +EAR Q+EK + K Q VE
Sbjct: 602 ALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVET 661
Query: 309 ISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 368
E A + EL + E+ K E E +L+EQ+ ++S ++
Sbjct: 662 ARQEQHEAQAQVAELELQLRSEQQKATE--KERVAQEKDQLQEQLQALKESLKVTKGSLE 719
Query: 369 MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESL 423
E L ++ I+ K + + ++ + E ++ E++ K + +L+ L
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774
Score = 60.5 bits (145), Expect = 3e-09
Identities = 69/349 (19%), Positives = 150/349 (42%), Gaps = 23/349 (6%)
Query: 66 SQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
S L + H L ++ + + Q++ E K+ EEL K++ L+ + +R
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQ 1403
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
R + E+ L K+ E + + ++ Y +Q+S L+ LAE++ +
Sbjct: 1404 R--------ELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLG 1455
Query: 186 AQLVNRKQKLESVELSSQSE--IQHLSSKLERANDTICANELEIERLTMRVNDLV----G 239
+ +Q LE VEL E +Q L++ A + + E + + + G
Sbjct: 1456 ERANLGRQFLE-VELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 240 TSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
+ VL+E+Q+ +E+ ++ +E L+ +RE ++ + ++ + Q+K+KA
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
Query: 300 TNTQHAVEAISLESVSATCKQLSQELMEKYE-------ELKRMEAHNNEYKAEIKKLKEQ 352
Q + + A +L +L +K + ++++ + H + K + ++L+EQ
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
Query: 353 ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRA 401
+ EQ E ++ E L EL Q + + + + ++R+
Sbjct: 1635 LRSLEQLQKENKE-LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS 1682
Score = 59.3 bits (142), Expect = 7e-09
Identities = 113/494 (22%), Positives = 193/494 (39%), Gaps = 125/494 (25%)
Query: 9 QNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE---QELKSLR 65
Q RG L +A EL ++ + ++ E+ AL L +E QEL LR
Sbjct: 1011 QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLR 1070
Query: 66 SQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
G+ Q++E E E +Q +K+L E+L K+ +E
Sbjct: 1071 ----------GLEAAQIKELE--------ELRQTVKQLKEQLA-----------KKEKEH 1101
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE----AQRKALAEQS 181
+ E E K+E R + E+Q Q+Q SLE A+R + AE+
Sbjct: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERD 1161
Query: 182 ---EIIQAQLVNRKQKL---ESVELSSQSEIQHLSSKL---------------------E 214
E +Q QL + Q+L +S S+Q E+ +K+ E
Sbjct: 1162 SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
Query: 215 RANDTICANELEIERLTMRVNDLVGTSMTV---LQEQQQKEEKLRESEKLLEA------- 264
R N I + E E+ L +V + G S + + + +K +KL E +LL+A
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
Query: 265 ---------------LQEE-----------KRELKAALQSQENLIHEARIQKEKLQEKVK 298
L+EE ++EL + + E L E + +EK +K +
Sbjct: 1282 RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
A +T + LE S + L EL+ ++++A E A K+ +E++ Q +Q
Sbjct: 1342 ALST------LQLEHTST--QALVSELLPAKHLCQQLQA---EQAAAEKRHREELEQSKQ 1390
Query: 359 SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 418
A G++ E+ +EL G + +++ + + A+ E +
Sbjct: 1391 ----AAGGLRAELLRAQREL-----------GELIPLRQKVAEQERTAQQLRAEKASYAE 1435
Query: 419 QLESLKLENRHLSE 432
QL LK + L+E
Sbjct: 1436 QLSMLKKAHGLLAE 1449
Score = 57.8 bits (138), Expect = 2e-08
Identities = 95/462 (20%), Positives = 195/462 (42%), Gaps = 65/462 (14%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ E+E ++L+K+ VA + +E + +++L +L+ + + +E+
Sbjct: 798 TAESECEQLVKE----VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMR--EFRGNTKNHREDRS 137
++V E + + EL +LH L R+ +++Q+K++R + + +E +
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLA---RALQQVQEKEVRAQKLADDLSTLQEKMA 910
Query: 138 EIERLTAKIEEFRQKSLDWEK--QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL 195
+ A++E +K+ + ++ R + ++ + + Q + L EQ Q + + L
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG---RQFCSTQAAL 967
Query: 196 ESVELSSQ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+++E ++ +E++ L + L + + ER R+ G + L ++
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLE 312
+L +L AL E++ E QE L H ++ K QE K + A + LE
Sbjct: 1028 AELEM--RLQNALNEQRVEFATL---QEALAHALTEKEGKDQELAKLRGLE-AAQIKELE 1081
Query: 313 SVSATCKQLSQELMEKYEELKRMEAHNNE--------------YKAEIKKLKEQI-LQGE 357
+ T KQL ++L +K +E +E +AE+ KL++Q Q E
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
Query: 358 QSYS----------------SALEGMKMEISHLTQEL---------HQRDITIASTK-GS 391
Q+ S SALE ++ ++ QEL QR++ TK
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 392 SSDMEKRLRAEMQKAEDKAVEHKEILDQL-ESLKLENRHLSE 432
S E +A++ + +A ++ L E + + NR + E
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243
Score = 47.8 bits (112), Expect = 2e-05
Identities = 34/122 (27%), Positives = 66/122 (54%), Gaps = 4/122 (3%)
Query: 55 KIREQELKSLRSQLDVTHKEVGMLHQQVEEHE---KIKQEMTMEYKQELKKLHEELCILK 111
K+++Q+LK++++Q + +E L Q+ E + K++ YK +++K K
Sbjct: 1566 KVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1625
Query: 112 RSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE 171
+ ++LQ+ Q+R K ++E R+E ERL ++++ K+ + E+ QV SLE
Sbjct: 1626 QQNQELQE-QLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684
Query: 172 AQ 173
AQ
Sbjct: 1685 AQ 1686
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 84.3 bits (207), Expect = 2e-16
Identities = 104/426 (24%), Positives = 193/426 (45%), Gaps = 45/426 (10%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
E +EL +Q + M ++ WE K+REQE K R + + +E M Q E
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEE-------KMREQEEKMWRQEERLWEQEKQMREQ--E 389
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK----KQMREFRGNTKNHREDRSEI 139
+ + ++E E + L++ E + ++ +E+++K K+M+E T++ E E
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE 449
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL------EAQRKALAEQSEII--QAQLVNR 191
ER+ + ++ R++ +Q Q+Q ++ E Q++ L EQ E + Q ++ +
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 192 KQKL--------ESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMT 243
++K+ + E+ Q + K+ D + E ++ ++ D
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 244 VLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQE-KVK 298
QEQ++K EEK+RE E++ E +++ RE + ++ QE + E Q+EK+QE + K
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMRER-EKKMREEEEMMREQEEKMQE---QEEKMQEQEEK 625
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
+ ++ + K QE EK E +R+ E E +K++EQ EQ
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQE--EKMWEQQRL-PEQKEKLWEHEKMQEQEKMQEQ 682
Query: 359 SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE---MQKAEDKAVEHKE 415
E KME QE D + S + EK++R E M++ E+K E +E
Sbjct: 683 E-EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 416 ILDQLE 421
+ + E
Sbjct: 742 KMQEQE 747
Score = 73.9 bits (180), Expect = 3e-13
Identities = 102/433 (23%), Positives = 191/433 (44%), Gaps = 60/433 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL+E K+I ++ W E K+REQE K R + + +E + Q+
Sbjct: 278 EEELREQEKKIR---KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQE 334
Query: 82 VE--------EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL--QKKQMREFRGNTKN 131
E E E+ QE + ++ +K+ E+ + R E+L Q+KQMRE ++
Sbjct: 335 KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 394
Query: 132 HREDRSEI-ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQ--L 188
E E ERL K E R++ WE+ + +++ ++ Q K +Q E +Q + +
Sbjct: 395 QEERMWEQDERLREKEERMREQEKMWEQVEKMREEK--KMQEQEKKTRDQEEKMQEEERI 452
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
R++K+ E + + + + + + E + E + +RL + L +QEQ
Sbjct: 453 REREKKMREEEETMREQEEKMQKQEENMWEQE-EKEWQQQRLPEQKEKL--WEQEKMQEQ 509
Query: 249 QQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH 304
++K EEK+R+ E++ QE+K + ++ QE+ + E Q+EK++++ + Q
Sbjct: 510 EEKIWEQEEKIRDQEEMWG--QEKKMWRQEKMREQEDQMWE---QEEKMRDQEQKMWDQE 564
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
E + ++ K QE EK E +RM + + E + ++EQ E+
Sbjct: 565 --ERMEKKTQEQEKKTWDQE--EKMREEERMREREKKMREEEEMMREQ----EEKMQEQE 616
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
E M+ + + ++ +MQ+ E+K E +E + + E
Sbjct: 617 EKMQEQEEKMWEQ----------------------EEKMQEQEEKMWEQEEKMWEQEEKM 654
Query: 425 LENRHLSEMVMKL 437
E + L E KL
Sbjct: 655 WEQQRLPEQKEKL 667
Score = 67.4 bits (163), Expect = 3e-11
Identities = 82/393 (20%), Positives = 172/393 (43%), Gaps = 40/393 (10%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
E +E ++ + M +K W K+REQE + + + +E M Q+
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQE--------KMREQEDQMWEQEEKMRDQEQKMWDQEER 566
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
+K +++ + QE K EE R E+ +K+MRE + RE +++
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEE-----RMRER--EKKMRE---EEEMMREQEEKMQEQE 616
Query: 144 AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQ-LVNRKQKLESVELSS 202
K++E +K WE++ + +Q+ E + K ++ ++ + Q L +K+KL E
Sbjct: 617 EKMQEQEEKM--WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ 674
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL 262
+ E K++ + I E ++E+ T T QE+ ++EE +RE EK +
Sbjct: 675 EQE------KMQEQEEKIWEQE-KMEKKTQEQE-----KKTWDQEKMREEESMREREKKM 722
Query: 263 EALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLS 322
+E RE + +Q QE + E Q+E++ E+ + Q K
Sbjct: 723 REEEEMMREQEEKMQEQEEKMQE---QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 323 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 382
E M++ E++ E + + +++ +E++ E+ + G + ++ +++ ++
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK----MRGQEEKMWGQEEKMWGQE 835
Query: 383 ITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE 415
+ + E+++ +MQ E+K E +E
Sbjct: 836 EKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE 868
Score = 63.9 bits (154), Expect = 3e-10
Identities = 59/281 (20%), Positives = 131/281 (46%), Gaps = 34/281 (12%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEH 85
+++ +Q + M ++ WE K+ EQE K Q KE H++++E
Sbjct: 624 EKMWEQEEKMQEQEEKMWEQEE-------KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 86 EKIKQEMTMEYKQEL--KKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
EK++++ ++QE KK E+ K+++++ + ++ R K RE+ +
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQE---KKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 144 AKIEEFRQKSLD-----WEKQRLIYQQQVSSLEAQRKALAEQSEII--------QAQLVN 190
K++E +K + WE++ +++Q+ E QR L EQ E + Q ++
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR--LPEQKEKLWEHEKMQEQEKIWE 791
Query: 191 RKQKLESVELSSQSEIQHL---SSKLERANDTICANELEI----ERLTMRVNDLVGTSMT 243
+++K+ E + + + + K+ + + E ++ E++ + + G
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
+ ++ Q +EEK+RE E+ + +E+ RE + ++ QE I+
Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
Score = 63.5 bits (153), Expect = 4e-10
Identities = 80/406 (19%), Positives = 185/406 (45%), Gaps = 41/406 (10%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCIL 110
E L ++E + K R++ + + L +++ E+ +E + +++ +K+ + L
Sbjct: 243 EIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERL 302
Query: 111 KRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL 170
+ K+++++ + +R K RE E+ ++ E QK L +++++ Q+Q +
Sbjct: 303 REQEGKMREQEEKMWR-QEKRLREQEKELREQEKELRE--QKELREQEEQM--QEQEEKM 357
Query: 171 EAQRKALAEQSEII----------QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTI 220
Q + + EQ E + + Q+ ++QK+ E + + L K ER +
Sbjct: 358 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 417
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQ-QKEEKLRESEKLLEALQEEKRELKAALQSQ 279
E ++E++ T QE++ Q+EE++RE EK + +E RE + +Q Q
Sbjct: 418 KMWE-QVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Query: 280 ENLI---HEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRME 336
E + E Q+++L E+ + Q ++ + +++ E+ E+++ E
Sbjct: 477 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ------------EQEEKIWEQEEKIRDQE 524
Query: 337 AHNNEYKAEIKKL--KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSD 394
E + KK+ +E++ + E E M+ + + + + + + + D
Sbjct: 525 ----EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 395 MEKRLRAE--MQKAEDKAVEHKEIL-DQLESLKLENRHLSEMVMKL 437
E+++R E M++ E K E +E++ +Q E ++ + + E K+
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
Score = 56.6 bits (135), Expect = 5e-08
Identities = 59/289 (20%), Positives = 134/289 (46%), Gaps = 24/289 (8%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ--VE 83
+++ +Q + M ++ WE K++EQE K + + +E M QQ E
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEE-------KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
+ EK+ + M+ ++++++ E++ ++ +K Q+++ + + E E E+
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKM 722
Query: 144 AKIEEF-RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII--QAQLVNRKQKL-ESVE 199
+ EE R++ ++Q Q+Q + Q + + EQ E + Q +L +K+KL E +
Sbjct: 723 REEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 782
Query: 200 LSSQSEIQHLSSKLERANDTICANELEI----ERLTMRVNDLVGTSMTVLQEQQ----QK 251
+ Q +I K+ + + E ++ E++ + + G + +++ Q+
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQE 842
Query: 252 EEKLRESEKLLEALQ---EEKRELKAALQSQENLIHEARIQKEKLQEKV 297
E+ + EK+ E +Q E+ RE + ++ QE + E + +EK+
Sbjct: 843 EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/320 (20%), Positives = 137/320 (42%), Gaps = 29/320 (9%)
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA-E 179
+ ++ G + E++R + + R K D + L ++ SLE R + E
Sbjct: 163 ESKDLAGRLHHSWHFAGELQRALSAVST-RHKKADRYIEELTKERDALSLELYRNTITNE 221
Query: 180 QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ + A+L + ES + Q ++ L KLERA + +
Sbjct: 222 ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN------------- 268
Query: 240 TSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
T+ +E ++EE+LRE EK + +E+ + L+ QE + E Q+EK+ + K
Sbjct: 269 ---TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE---QEEKMWRQEKR 322
Query: 300 TNTQHAVEAISLESVSATCKQL---SQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
Q E E K+L +++ E+ E++ E E + ++ + +E++ +
Sbjct: 323 LREQEK-ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
Query: 357 EQSYSSALEGMKMEISHLTQE---LHQRDITIASTKGSSSDMEK-RLRAEMQKAEDKAVE 412
E+ + M+ + + ++ L +++ + + +EK R +MQ+ E K +
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRD 441
Query: 413 HKEILDQLESLKLENRHLSE 432
+E + + E ++ + + E
Sbjct: 442 QEEKMQEEERIREREKKMRE 461
Score = 37.0 bits (84), Expect = 0.039
Identities = 37/195 (18%), Positives = 85/195 (43%), Gaps = 20/195 (10%)
Query: 256 RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVS 315
+++++ +E L +E+ L L E + + +LQEK+ ++ + ++++
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVK--- 249
Query: 316 ATCKQLSQELMEKYEELKRM--EAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISH 373
EL K E K + + N + E+ + +E++ + E+ E M +
Sbjct: 250 --------ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ--- 298
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRA---EMQKAEDKAVEHKEILDQLESLKLENRHL 430
+ L +++ + + EKRLR E+++ E + E KE+ +Q E ++ + +
Sbjct: 299 -EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKM 357
Query: 431 SEMVMKLELGLHERW 445
E K+ + W
Sbjct: 358 WEQEEKMREQEEKMW 372
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 84.3 bits (207), Expect = 2e-16
Identities = 96/448 (21%), Positives = 215/448 (47%), Gaps = 59/448 (13%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKS-LRSQLDVTHKEVGMLHQQV 82
+L++L +++ + +K+ ++ K+ E +L+S L+ L++ +++ L ++
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE--FRGNTKNHREDRS--- 137
EE + Y Q+L+ +EL +K++YE L+++Q E + + ED
Sbjct: 984 EE--------STNYNQQLR---QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E + T ++ + + + ++ E+ Q + +L+ Q K L Q+ +QAQ++ +++ S
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEI----ERLTMRVNDLVGTSMTVLQEQQQK-- 251
++ + +Q ++KL+ N T+ + + +L ++ + L + +V++E++
Sbjct: 1093 LQ-EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 252 --EEKLRESEKL----------LEALQEEKRELKAA----------LQSQENLIHEARIQ 289
+ +++ EKL E+L + LK+A L+ + N + + + Q
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
Query: 290 KEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 349
E L++ +K + +E + E+V+A K+L E ++ + + K L
Sbjct: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1271
Query: 350 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTK-GSSSDMEKRLRAEMQKAED 408
K +L + + LE E S L ++ Q DIT STK + ++ +L+ +++
Sbjct: 1272 KS-LLNNSKLEQTRLEA---EFSKLKEQYQQLDIT--STKLNNQCELLSQLKGNLEE--- 1322
Query: 409 KAVEHKEILDQLESLKLENRHLSEMVMK 436
E++ +LDQ+++L L+NR L E M+
Sbjct: 1323 ---ENRHLLDQIQTLMLQNRTLLEQNME 1347
Score = 79.3 bits (194), Expect = 7e-15
Identities = 110/436 (25%), Positives = 205/436 (47%), Gaps = 59/436 (13%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEAR---IQKEK--LQEKVKATNTQHAVEAISLESV 314
+ L++E L ++L+ + + EAR I+KE L E +K T+++ L +
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK-------LSKI 606
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNE--YKAEIKKLKEQILQGEQSYSSALEGMKMEIS 372
+Q+ +EL E+ +R E NE + + +L ++ + + +E ++ E S
Sbjct: 607 EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS 666
Query: 373 HLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE-------SLKL 425
L +E + T+ S K + +E L E + +++ +E + ++ L+ L+L
Sbjct: 667 ELERENRKLKKTLDSFKNLTFQLES-LEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 426 ENRHLSEMVMKLELGL 441
EN+ L +L+ GL
Sbjct: 726 ENKELESEKEQLKKGL 741
Score = 75.9 bits (185), Expect = 8e-14
Identities = 101/429 (23%), Positives = 192/429 (44%), Gaps = 52/429 (12%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E E Q L K+++I+ ++E +L+ C + + +K ++QL+ K + L +
Sbjct: 497 EKENQRLSKKVEIL----ENEIVQEKQSLQNCQNLSKDLMKE-KAQLE---KTIETLREN 548
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
E KI + QE + L++ + L++ + + ++++ K E E
Sbjct: 549 SERQIKILE-------QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 142 LTAKIE-EFRQ--KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+KIE E RQ K L+ K++ ++ LE + L +++E++Q ++ N K E +
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEK---GERAEELENELHHLEKENELLQKKITNLKITCEKI 658
Query: 199 ELSSQ--SEIQHLSSKLERANDTICA------------NELEIERLTMRVNDLVGTSMTV 244
E Q SE++ + KL++ D+ ++L+ E L +R N ++
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENL---IHEARIQKEKLQEKVKATN 301
Q Q E K ESEK E L++ LKA+ + E L I+ ++LQ+ ++ +N
Sbjct: 719 KMAQLQLENKELESEK--EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
Query: 302 TQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYS 361
+ LES + +Q L + EELK + + E K L+++ Q E+
Sbjct: 777 KKIQ----QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 362 SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE 421
++ E L Q+ +D T+ ++EK E + + +KE +L+
Sbjct: 833 Q----LEKENKRLRQQAEIKDTTLEENNVKIGNLEK----ENKTLSKEIGIYKESCVRLK 884
Query: 422 SLKLENRHL 430
L+ EN+ L
Sbjct: 885 ELEKENKEL 893
Score = 68.6 bits (166), Expect = 1e-11
Identities = 110/483 (22%), Positives = 201/483 (41%), Gaps = 74/483 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEEL------CILKRSYEKLQKKQMREFRGN 128
L QQ E + +E ++ ++E K L +E+ C+ + EK K+ ++ +
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 129 TKNH---RED-----------RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR 174
K RED +++E+LT ++E+ + K+RL++ +Q S+ +++
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK-----IGLNKERLLHDEQ-STDDSRY 954
Query: 175 KALAEQSE-IIQAQLVNRKQKLESVEL---SSQSEIQHLSSKLE--RANDTICANELEIE 228
K L + E ++ L +++K+ ++E S + Q L +L+ + N + E
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Query: 229 RLTMRVNDLVGTSMTVLQEQQQK-EEKLRESEKLLEA------LQEEKRELKAALQSQE- 280
R+ + G +E Q+ E L+ ++L+E LQ EK+ LK L+ E
Sbjct: 1015 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1074
Query: 281 -NLIHEARI-----QKEKLQEKVKATNTQHA---VEAISLESVSATCKQLSQELMEKYEE 331
N +A+I Q LQE+ TQ+A VE +L S S + + +L+ +
Sbjct: 1075 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1134
Query: 332 LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI------------SHLTQELH 379
L+ + + ++K L + +++ + E E +H E+
Sbjct: 1135 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1194
Query: 380 QRDIT-----IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
RD+ + KG D+EK L+ E +K + H+ + + + L EN L+
Sbjct: 1195 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1254
Query: 435 MKL 437
+L
Sbjct: 1255 SQL 1257
Score = 63.2 bits (152), Expect = 5e-10
Identities = 88/400 (22%), Positives = 172/400 (43%), Gaps = 40/400 (10%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++ +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+ R ++ EL + E KLE +IE RV +L + +L
Sbjct: 300 SDA--RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 246 QEQQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ + E++L S+KL E L++E +LKA L E E + ++K++E ++
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDME---MERDMDRKKIEELMEENM 413
Query: 302 TQHAVEAIS----------LESVSATC-------KQLSQELME-KYEELKRMEAHNNEYK 343
T + S LE +S T K L E+ E L ++E N
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 344 AEIKKLKEQILQGEQSYSSAL------EGMKMEISHLTQELHQRDITIASTKGSSSDMEK 397
+++L+ + E + S L + + ++ L E+ Q ++ + + S D+ K
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMK 533
Query: 398 RLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKL 437
+A+++K + E+ E Q++ L+ EN HL++ V L
Sbjct: 534 E-KAQLEKTIETLRENSE--RQIKILEQENEHLNQTVSSL 570
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 17/251 (6%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQ-QVEEHEKIKQEMTMEYKQELKKLHEELCI 109
E+ +K RE +LKSL L H+++ +LH+ Q E+E + + LK H+ L +
Sbjct: 1140 ESVIKERE-DLKSLYDSLIKDHEKLELLHERQASEYESL-----ISKHGTLKSAHKNLEV 1193
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
R E + +++ +G ++ E ++E+ +E +++ E ++L +
Sbjct: 1194 EHRDLEDRYNQLLKQ-KGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--R 1249
Query: 170 LEAQRKALAEQSEIIQAQLVNRKQKLESVELSS---QSEIQHLSSKLERANDTICANELE 226
L L +++E++Q N K L + +L ++E L + ++ + T +
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1309
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
E L+ +L + +L + Q + ++ LLE E K + + ++E
Sbjct: 1310 CELLSQLKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
Query: 287 RIQKEKLQEKV 297
R QKEKL+EK+
Sbjct: 1367 RRQKEKLEEKI 1377
Score = 35.8 bits (81), Expect = 0.087
Identities = 31/148 (20%), Positives = 63/148 (42%), Gaps = 17/148 (11%)
Query: 308 AISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL------QGEQSYS 361
++ L A ++L QEL EK E+L + + + E+K+L+++ + + + Y
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 362 SALEGMK----------MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAV 411
L+ ++ E+S + LH + A + D + L + ED+
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQLE 368
Query: 412 EHKEILDQLESLKLENRHLSEMVMKLEL 439
+ D+L L+ EN L + +E+
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEM 396
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 83.6 bits (205), Expect = 4e-16
Identities = 92/445 (20%), Positives = 204/445 (45%), Gaps = 48/445 (10%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV----------- 82
K EWE + E + KIREQE K R + + KE M Q+
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 83 ------EEHEKIK--QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
E+ EK++ +EM E ++++++L E++ ++ E+ +K+Q E + +E
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
+++ R KI E +K + EK+ +Q + Q K E+ Q ++ +++K
Sbjct: 428 QEAKMWRQEEKIREQEEKIREQEKK---MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 195 L-ESVELSSQSEIQH-LSSKLERANDTICANELEIERLTMRV---NDLVGTSMTVLQEQQ 249
+ E E+ Q E H K+ + + + E +I ++ + + ++EQ+
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544
Query: 250 Q---KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+ +EEK+ E EK+ E +E+++E + + QE I E + + +EK++ +
Sbjct: 545 EMWREEEKMHEQEKIWE--EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEG 366
+ + ++ +++ E+ E+++ E E + ++ +E++ GEQ +
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKM--GEQEEKMCEQE 660
Query: 367 MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE---MQKAEDKAVEHKEIL----DQ 419
KM+ T + +++ I + + E+++R + MQ+ E+K E +E + ++
Sbjct: 661 EKMQEQEET--MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 420 LESLKLENRHLSEMVMKLELGLHER 444
++ + + R E + + E+ L ++
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQ 743
Score = 72.8 bits (177), Expect = 6e-13
Identities = 79/367 (21%), Positives = 171/367 (46%), Gaps = 30/367 (8%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 444
Query: 62 KSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQEL----KKLHEELCILKRSYEKL 117
K +R Q K++ +++ E EKI++E + ++E+ +K+HE+ I ++ EK+
Sbjct: 445 K-IREQ----EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK-EKM 498
Query: 118 QKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL 177
+++ + + K R++ +I KI E +K W ++ I +Q+ E ++ +
Sbjct: 499 HEQEEKIRKQEEKVWRQEE-KIREQEEKIREQEEKM--WRQEEKIREQEEMWREEEK--M 553
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANE---LEIERLTMRV 234
EQ +I + + ++Q+ E + +I+ K+ R + I E E E +
Sbjct: 554 HEQEKIWEEE---KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 235 NDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK 290
+ + +QEQ++K EEK+RE E++ + +E+ E + + QE + E
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
+ +EK++ + + + ++ +++ E+ E++ E E + ++++ +
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 351 EQILQGE 357
E++ + E
Sbjct: 731 EKMWEQE 737
Score = 67.8 bits (164), Expect = 2e-11
Identities = 87/420 (20%), Positives = 187/420 (44%), Gaps = 53/420 (12%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 161
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 280 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 318
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+ ++ QE I E R Q+E + EK + Q + E + ++ + + E
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM----RRQEEMMWE 374
Query: 328 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAS 387
K E+++R E E + +I++L+E++ + E+ + + E ++ +++ +
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 388 TKGSSSDMEKRLRAE---MQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHER 444
+ + E+++R + M + E+K E ++I ++ E R E + + E +HE+
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE------EKRQEQEEMWRQEEKIHEQ 488
Score = 54.7 bits (130), Expect = 2e-07
Identities = 65/288 (22%), Positives = 128/288 (44%), Gaps = 41/288 (14%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE-- 83
QE M + + + ++ W + E KIR+QE K R + + +E + Q+ +
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMW 534
Query: 84 -EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
+ EKI+++ M ++E K+HE+ I + EK Q+++ + +R K RE ++ R
Sbjct: 535 RQEEKIREQEEMWREEE--KMHEQEKIWEE--EKRQEQEDKMWRQEEKI-REQEEKVWRQ 589
Query: 143 TAKIEEFRQKSLDWE----KQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
KI E +K + E KQ ++Q ++ Q + + EQ E I+ Q +++ E +
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKM 649
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL---VGTSMTVLQEQQQK---- 251
+ ++ K++ +T+ E +I ++ + + ++QEQ++K
Sbjct: 650 G-EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708
Query: 252 --------------EEKLRESEKLLEALQEEKRELKAALQSQENLIHE 285
EEK+R E E+ E + L+ QE + E
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQE-------EKMWEQEVRLRQQEEKMQE 749
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 83.2 bits (204), Expect = 5e-16
Identities = 93/418 (22%), Positives = 180/418 (43%), Gaps = 42/418 (10%)
Query: 59 QELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTM-----EYKQELKKLHEELCILKRS 113
+E++ +R + + + G L Q E+ +++ E E ++ LK + + +
Sbjct: 36 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 95
Query: 114 YEKLQKKQMREFRGNTKNHREDRSEIERLTA-------KIEEFRQKSLDWEKQRLIYQQQ 166
EK ++ E K E R E ++L K + F ++ LD K+ ++ +
Sbjct: 96 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 155
Query: 167 VSSLEAQRKALAEQSEIIQAQ-LVNRKQ--KLESVELSSQSEIQHLSSKLERANDTICAN 223
SL+A ++ A+ + Q Q + RK KL++ Q E L K ++ +
Sbjct: 156 --SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIA 213
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKREL----------K 273
E ++ L +++D M +L + ++ E +L + E LQ++ +L +
Sbjct: 214 ENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR---ERLQQQASDLVLKASHIGMLQ 270
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK 333
A +QE I + +K ++ E++ + A +S+ KQ EL +K E K
Sbjct: 271 ATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAK 330
Query: 334 R--MEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGS 391
R E + E K +L+E++ Q +++S LE + + + +H I K
Sbjct: 331 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSN--AIRDKKKL 388
Query: 392 SSDMEKR-------LRAEMQKAEDKAVEHKEIL-DQLESLKLENRHLSEMVMKLELGL 441
D+E++ L + + + + KE+L D+L + E HL +MV K E GL
Sbjct: 389 QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL 446
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/433 (21%), Positives = 194/433 (44%), Gaps = 46/433 (10%)
Query: 17 FLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVG 76
FL S L E KQ + + K +E A T + E+ELK+L+S+L+ +EV
Sbjct: 303 FLRSKTQSLDEEQKQQILELEKKVNE------AKRTQQEYYERELKNLQSRLE---EEVT 353
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDR 136
L+ E H K +E+ ++ ++ +H R +KLQ + + N ED+
Sbjct: 354 QLN---EAHSKTLEELAWKHHMAIEAVHSNAI---RDKKKLQMDLEEQHNKDKLNLEEDK 407
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIY--------QQQVSSLEAQRKALAEQSEIIQAQL 188
+++++ ++E + L+ Q + + +Q + S E +L + E +Q +L
Sbjct: 408 NQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNEL 467
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICA----NELEIER----LTMRVNDLVGT 240
K L+ + + + L + ++ +TI A +L++++ L ++ + +
Sbjct: 468 DLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQ 527
Query: 241 SMTVLQEQ---QQKEEKLRESEKLLEALQEEKRELKAALQSQ-ENLIHEARIQKEKLQEK 296
+ L+E+ Q +E+K +LL+ EK + + Q + E+L+++ + K+ L+ +
Sbjct: 528 ECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQ 587
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
+ + T SL+ + A Q Q L ++ EEL+ ++ E L Q ++
Sbjct: 588 LSQSQT-------SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE 640
Query: 357 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 416
E+ ++ H + +D S +G +ME+ L+ + ED E K +
Sbjct: 641 EKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELED---EGKAM 697
Query: 417 LDQLESLKLENRH 429
L L S +L ++H
Sbjct: 698 LASLRS-ELNHQH 709
Score = 72.4 bits (176), Expect = 8e-13
Identities = 76/391 (19%), Positives = 170/391 (43%), Gaps = 37/391 (9%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
L+ +E +K L S+ ++ + L ++ Q + E KQ++ +L +++
Sbjct: 269 LQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNE 328
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLD---WEKQRLIYQQQ 166
KR+ ++ +++++ + S +E ++ E K+L+ W+ I
Sbjct: 329 AKRTQQEYYERELKNLQ----------SRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVH 378
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE 226
+++ ++K + E Q K LE + Q E+++L LE +T
Sbjct: 379 SNAIRDKKKLQMDLEE----QHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGH 434
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQS------QE 280
++ + + +G++ ++ Q +E+L+ L+ ++ +E K AL + QE
Sbjct: 435 LQDMVRKSEQGLGSAEGLIASLQDSQERLQNE---LDLTKDSLKETKDALLNVEGELEQE 491
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNN 340
HE I K +EK+K H +E E++ C +L +EL ++EE K+
Sbjct: 492 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK------ 545
Query: 341 EYKAEIKKLKEQILQ-GEQSYSSALEGMKMEISHLTQ----ELHQRDITIASTKGSSSDM 395
+++ +LK++ S+ +E + +IS L Q +L Q ++ + +
Sbjct: 546 SAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 605
Query: 396 EKRLRAEMQKAEDKAVEHKEILDQLESLKLE 426
+RL E+++ E++ + + L + L +
Sbjct: 606 RQRLTQELEELEEQHQQRHKSLKEAHVLAFQ 636
Score = 60.8 bits (146), Expect = 3e-09
Identities = 82/379 (21%), Positives = 158/379 (41%), Gaps = 27/379 (7%)
Query: 9 QNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQL 68
Q G G + S + + L ++D+ K S E + L E EL+ R Q
Sbjct: 444 QGLGSAEGLIASLQDSQERLQNELDLT---KDSLKETKDALLNV-----EGELEQERQQH 495
Query: 69 DVT---HKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
+ T KE L H+ ++ + T +QE KL EEL + +K Q+ +
Sbjct: 496 EETIAAMKEEEKLKVDKMAHD-LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 554
Query: 126 RGNTKNHRED--RSEIERLTAKIEEFRQK-SLDWEKQRLIYQQQVSSLEAQRKALAEQSE 182
+ KN D + ++E L +I +Q + + + QQ + +R+ L ++ E
Sbjct: 555 KDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELE 614
Query: 183 IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM 242
++ Q R + L+ + + ++ K +RA + + E +++ D SM
Sbjct: 615 ELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLK--DAHRESM 672
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT 302
+ + ++E + E L++E + + A+L+S+ N H A I + +
Sbjct: 673 EGFRIEMEQELQTLRFE-----LEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 727
Query: 303 QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 362
+ +E S++ K+ + + EEL+ E H +E E++ L E I + +
Sbjct: 728 KMELER-SIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENI----SALTK 782
Query: 363 ALEGMKMEISHLTQELHQR 381
LE EI + E +Q+
Sbjct: 783 ELEFKGKEILRIRSESNQQ 801
Score = 43.1 bits (100), Expect = 5e-04
Identities = 55/217 (25%), Positives = 100/217 (46%), Gaps = 42/217 (19%)
Query: 220 ICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL-----------LEALQ-E 267
+CA ++R+ V S V + +++ EEKLR +L LE LQ
Sbjct: 21 LCAEAQHVQRI-------VTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAA 73
Query: 268 EKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+RE++ L+SQ++ H A + K QEK + H +E SL + + ++L+E
Sbjct: 74 HRREIQELLKSQQD--HSASVNKG--QEKAEEL---HRMEVESLNKMLEELRLERKKLIE 126
Query: 328 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAS 387
YE ++ + Y+ E+ LK L +S L+ K + + L +E ++ +
Sbjct: 127 DYE--GKLNKAQSFYERELDTLKRSQLFTAES----LQASKEKEADLRKEFQGQEAILRK 180
Query: 388 TKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
T G +L+ E+Q +D+A +LD+ + L+
Sbjct: 181 TIG-------KLKTELQMVQDEA---GSLLDKCQKLQ 207
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 83.2 bits (204), Expect = 5e-16
Identities = 93/418 (22%), Positives = 180/418 (43%), Gaps = 42/418 (10%)
Query: 59 QELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTM-----EYKQELKKLHEELCILKRS 113
+E++ +R + + + G L Q E+ +++ E E ++ LK + + +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 215
Query: 114 YEKLQKKQMREFRGNTKNHREDRSEIERLTA-------KIEEFRQKSLDWEKQRLIYQQQ 166
EK ++ E K E R E ++L K + F ++ LD K+ ++ +
Sbjct: 216 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 275
Query: 167 VSSLEAQRKALAEQSEIIQAQ-LVNRKQ--KLESVELSSQSEIQHLSSKLERANDTICAN 223
SL+A ++ A+ + Q Q + RK KL++ Q E L K ++ +
Sbjct: 276 --SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIA 333
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKREL----------K 273
E ++ L +++D M +L + ++ E +L + E LQ++ +L +
Sbjct: 334 ENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR---ERLQQQASDLVLKASHIGMLQ 390
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK 333
A +QE I + +K ++ E++ + A +S+ KQ EL +K E K
Sbjct: 391 ATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAK 450
Query: 334 R--MEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGS 391
R E + E K +L+E++ Q +++S LE + + + +H I K
Sbjct: 451 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSN--AIRDKKKL 508
Query: 392 SSDMEKR-------LRAEMQKAEDKAVEHKEIL-DQLESLKLENRHLSEMVMKLELGL 441
D+E++ L + + + + KE+L D+L + E HL +MV K E GL
Sbjct: 509 QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL 566
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/433 (21%), Positives = 194/433 (44%), Gaps = 46/433 (10%)
Query: 17 FLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVG 76
FL S L E KQ + + K +E A T + E+ELK+L+S+L+ +EV
Sbjct: 423 FLRSKTQSLDEEQKQQILELEKKVNE------AKRTQQEYYERELKNLQSRLE---EEVT 473
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDR 136
L+ E H K +E+ ++ ++ +H R +KLQ + + N ED+
Sbjct: 474 QLN---EAHSKTLEELAWKHHMAIEAVHSNAI---RDKKKLQMDLEEQHNKDKLNLEEDK 527
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIY--------QQQVSSLEAQRKALAEQSEIIQAQL 188
+++++ ++E + L+ Q + + +Q + S E +L + E +Q +L
Sbjct: 528 NQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNEL 587
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICA----NELEIER----LTMRVNDLVGT 240
K L+ + + + L + ++ +TI A +L++++ L ++ + +
Sbjct: 588 DLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQ 647
Query: 241 SMTVLQEQ---QQKEEKLRESEKLLEALQEEKRELKAALQSQ-ENLIHEARIQKEKLQEK 296
+ L+E+ Q +E+K +LL+ EK + + Q + E+L+++ + K+ L+ +
Sbjct: 648 ECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQ 707
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
+ + T SL+ + A Q Q L ++ EEL+ ++ E L Q ++
Sbjct: 708 LSQSQT-------SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE 760
Query: 357 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 416
E+ ++ H + +D S +G +ME+ L+ + ED E K +
Sbjct: 761 EKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELED---EGKAM 817
Query: 417 LDQLESLKLENRH 429
L L S +L ++H
Sbjct: 818 LASLRS-ELNHQH 829
Score = 72.4 bits (176), Expect = 8e-13
Identities = 76/391 (19%), Positives = 170/391 (43%), Gaps = 37/391 (9%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
L+ +E +K L S+ ++ + L ++ Q + E KQ++ +L +++
Sbjct: 389 LQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNE 448
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLD---WEKQRLIYQQQ 166
KR+ ++ +++++ + S +E ++ E K+L+ W+ I
Sbjct: 449 AKRTQQEYYERELKNLQ----------SRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVH 498
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE 226
+++ ++K + E Q K LE + Q E+++L LE +T
Sbjct: 499 SNAIRDKKKLQMDLEE----QHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGH 554
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQS------QE 280
++ + + +G++ ++ Q +E+L+ L+ ++ +E K AL + QE
Sbjct: 555 LQDMVRKSEQGLGSAEGLIASLQDSQERLQNE---LDLTKDSLKETKDALLNVEGELEQE 611
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNN 340
HE I K +EK+K H +E E++ C +L +EL ++EE K+
Sbjct: 612 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK------ 665
Query: 341 EYKAEIKKLKEQILQ-GEQSYSSALEGMKMEISHLTQ----ELHQRDITIASTKGSSSDM 395
+++ +LK++ S+ +E + +IS L Q +L Q ++ + +
Sbjct: 666 SAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 725
Query: 396 EKRLRAEMQKAEDKAVEHKEILDQLESLKLE 426
+RL E+++ E++ + + L + L +
Sbjct: 726 RQRLTQELEELEEQHQQRHKSLKEAHVLAFQ 756
Score = 66.6 bits (161), Expect = 5e-11
Identities = 95/441 (21%), Positives = 179/441 (40%), Gaps = 35/441 (7%)
Query: 9 QNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQL 68
Q G G + S + + L ++D+ K S E + L E EL+ R Q
Sbjct: 564 QGLGSAEGLIASLQDSQERLQNELDLT---KDSLKETKDALLNV-----EGELEQERQQH 615
Query: 69 DVT---HKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
+ T KE L H+ ++ + T +QE KL EEL + +K Q+ +
Sbjct: 616 EETIAAMKEEEKLKVDKMAHD-LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 674
Query: 126 RGNTKNHRED--RSEIERLTAKIEEFRQK-SLDWEKQRLIYQQQVSSLEAQRKALAEQSE 182
+ KN D + ++E L +I +Q + + + QQ + +R+ L ++ E
Sbjct: 675 KDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELE 734
Query: 183 IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM 242
++ Q R + L+ + + ++ K +RA + + E +++ D SM
Sbjct: 735 ELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLK--DAHRESM 792
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT 302
+ + ++E + E L++E + + A+L+S+ N H A I + +
Sbjct: 793 EGFRIEMEQELQTLRFE-----LEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 847
Query: 303 QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 362
+ +E S++ K+ + + EEL+ E H +E E++ L E I + +
Sbjct: 848 KMELER-SIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENI----SALTK 902
Query: 363 ALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 422
LE EI + E +Q+ + D+ KRL E+ + K I+
Sbjct: 903 ELEFKGKEILRIRSESNQQ------IRLHEQDLNKRLEKELDVMTADHLREKNIM--RAD 954
Query: 423 LKLENRHLSEMVMKLELGLHE 443
N L E+ L++ L E
Sbjct: 955 FNKTNELLKEINAALQVSLEE 975
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 82.8 bits (203), Expect = 6e-16
Identities = 93/417 (22%), Positives = 201/417 (48%), Gaps = 59/417 (14%)
Query: 55 KIREQELKS-LRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRS 113
K+ E +L+S L+ L++ +++ L ++EE + Y Q+L+ +EL +K++
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEE--------STNYNQQLR---QELKTVKKN 1002
Query: 114 YEKLQKKQMRE--FRGNTKNHREDRS---EIERLTAKIEEFRQKSLDWEKQRLIYQQQVS 168
YE L+++Q E + + ED E + T ++ + + + ++ E+ Q +
Sbjct: 1003 YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1062
Query: 169 SLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEI- 227
+L+ Q K L Q+ +QAQ++ +++ S++ + +Q ++KL+ N T+ + +
Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQ-EQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 228 ---ERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEKL----------LEALQEEKR 270
+L ++ + L + +V++E++ + +++ EKL E+L +
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181
Query: 271 ELKAA----------LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQ 320
LK+A L+ + N + + + Q E L++ +K + +E + E+V+A K+
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1241
Query: 321 LSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQ 380
L E ++ + + K LK +L + + LE E S L ++ Q
Sbjct: 1242 LCGENDRLNHTYSQLLKETEVLQTDHKNLKS-LLNNSKLEQTRLEA---EFSKLKEQYQQ 1297
Query: 381 RDITIASTK-GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 436
DIT STK + ++ +L+ +++ E++ +LDQ+++L L+NR L E M+
Sbjct: 1298 LDIT--STKLNNQCELLSQLKGNLEE------ENRHLLDQIQTLMLQNRTLLEQNME 1346
Score = 79.3 bits (194), Expect = 7e-15
Identities = 110/436 (25%), Positives = 205/436 (47%), Gaps = 59/436 (13%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEAR---IQKEK--LQEKVKATNTQHAVEAISLESV 314
+ L++E L ++L+ + + EAR I+KE L E +K T+++ L +
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK-------LSKI 606
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNE--YKAEIKKLKEQILQGEQSYSSALEGMKMEIS 372
+Q+ +EL E+ +R E NE + + +L ++ + + +E ++ E S
Sbjct: 607 EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS 666
Query: 373 HLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE-------SLKL 425
L +E + T+ S K + +E L E + +++ +E + ++ L+ L+L
Sbjct: 667 ELERENRKLKKTLDSFKNLTFQLES-LEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 426 ENRHLSEMVMKLELGL 441
EN+ L +L+ GL
Sbjct: 726 ENKELESEKEQLKKGL 741
Score = 68.6 bits (166), Expect = 1e-11
Identities = 110/483 (22%), Positives = 198/483 (40%), Gaps = 75/483 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEEL------CILKRSYEKLQKKQMREFRGN 128
L QQ E + +E ++ ++E K L +E+ C+ + EK K+ ++ +
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 129 TKNH---RED-----------RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS----- 169
K RED +++E+LT ++E+ + K+RL++ +Q +
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK-----IGLNKERLLHDEQSTDDRYKL 955
Query: 170 LEAQRKALAEQS-EIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIE 228
LE++ ++ ++S EI + ++ + +LE +Q Q L K + N + E
Sbjct: 956 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL--KTVKKNYEALKQRQDEE 1013
Query: 229 RLTMRVNDLVGTSMTVLQEQQQK-EEKLRESEKLLEA------LQEEKRELKAALQSQE- 280
R+ + G +E Q+ E L+ ++L+E LQ EK+ LK L+ E
Sbjct: 1014 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1073
Query: 281 -NLIHEARI-----QKEKLQEKVKATNTQHA---VEAISLESVSATCKQLSQELMEKYEE 331
N +A+I Q LQE+ TQ+A VE +L S S + + +L+ +
Sbjct: 1074 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1133
Query: 332 LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI------------SHLTQELH 379
L+ + + ++K L + +++ + E E +H E+
Sbjct: 1134 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 380 QRDIT-----IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
RD+ + KG D+EK L+ E +K + H+ + + + L EN L+
Sbjct: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1253
Query: 435 MKL 437
+L
Sbjct: 1254 SQL 1256
Score = 63.2 bits (152), Expect = 5e-10
Identities = 88/400 (22%), Positives = 172/400 (43%), Gaps = 40/400 (10%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++ +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+ R ++ EL + E KLE +IE RV +L + +L
Sbjct: 300 SDA--RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 246 QEQQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ + E++L S+KL E L++E +LKA L E E + ++K++E ++
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDME---MERDMDRKKIEELMEENM 413
Query: 302 TQHAVEAIS----------LESVSATC-------KQLSQELME-KYEELKRMEAHNNEYK 343
T + S LE +S T K L E+ E L ++E N
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 344 AEIKKLKEQILQGEQSYSSAL------EGMKMEISHLTQELHQRDITIASTKGSSSDMEK 397
+++L+ + E + S L + + ++ L E+ Q ++ + + S D+ K
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMK 533
Query: 398 RLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKL 437
+A+++K + E+ E Q++ L+ EN HL++ V L
Sbjct: 534 E-KAQLEKTIETLRENSE--RQIKILEQENEHLNQTVSSL 570
Score = 62.8 bits (151), Expect = 7e-10
Identities = 95/451 (21%), Positives = 190/451 (42%), Gaps = 80/451 (17%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E+E ++L K ++++ A K +T LE + + E + L+ L+ ++K++ L +
Sbjct: 731 ESEKEQLKKGLELLKASFK-----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ Q++ ME Q L+K EEL I + E+L+K+
Sbjct: 786 L-------QDLEME-NQTLQKNLEELKISSKRLEQLEKEN-------------------- 817
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
KSL+ E +L ++ LE + K L +Q+EI L K+ ++E
Sbjct: 818 ----------KSLEQETSQL--EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 202 SQS---EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
+++ EI R + N+ ++R T+ + LV ++ E+ + ++ +
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT----NTQHAVEAISLESV 314
EKL L++ + L +++ ++ + KL+ +K + + A LE
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 315 SATCKQLSQEL---MEKYEELK--------------------RMEAHNNEYKAEIKKLKE 351
+ +QL QEL + YE LK + E + E E+ K+K+
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1045
Query: 352 QILQGEQ---SYSSALEGMKMEISHL-TQELHQRDITIASTKGSSSDMEKRLRAEMQKAE 407
++++ E+ + + + +K ++ L TQ + + +A + + S E+ + Q A+
Sbjct: 1046 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
Query: 408 DKAVEHKEILDQLESLKLENRHLSEMVMKLE 438
VE+ + Q SL +N L LE
Sbjct: 1106 -LQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 17/251 (6%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQ-QVEEHEKIKQEMTMEYKQELKKLHEELCI 109
E+ +K RE +LKSL L H+++ +LH+ Q E+E + + LK H+ L +
Sbjct: 1139 ESVIKERE-DLKSLYDSLIKDHEKLELLHERQASEYESL-----ISKHGTLKSAHKNLEV 1192
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
R E + +++ +G ++ E ++E+ +E +++ E ++L +
Sbjct: 1193 EHRDLEDRYNQLLKQ-KGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--R 1248
Query: 170 LEAQRKALAEQSEIIQAQLVNRKQKLESVELSS---QSEIQHLSSKLERANDTICANELE 226
L L +++E++Q N K L + +L ++E L + ++ + T +
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1308
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
E L+ +L + +L + Q + ++ LLE E K + + ++E
Sbjct: 1309 CELLSQLKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
Query: 287 RIQKEKLQEKV 297
R QKEKL+EK+
Sbjct: 1366 RRQKEKLEEKI 1376
Score = 35.8 bits (81), Expect = 0.087
Identities = 31/148 (20%), Positives = 63/148 (42%), Gaps = 17/148 (11%)
Query: 308 AISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL------QGEQSYS 361
++ L A ++L QEL EK E+L + + + E+K+L+++ + + + Y
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 362 SALEGMK----------MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAV 411
L+ ++ E+S + LH + A + D + L + ED+
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQLE 368
Query: 412 EHKEILDQLESLKLENRHLSEMVMKLEL 439
+ D+L L+ EN L + +E+
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEM 396
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 82.4 bits (202), Expect = 8e-16
Identities = 96/445 (21%), Positives = 196/445 (44%), Gaps = 51/445 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+++ + + ++E + A E C +Q +K+ + QL+ KE ++++
Sbjct: 874 EEKMVSLLQEKNDLQLQVQAEQDNLADAEERC----DQLIKN-KIQLEAKVKE---MNER 925
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
+E+ E++ E+T + + KL +E LKR + L+ +K+ KN E+
Sbjct: 926 LEDEEEMNAELTAKKR----KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEE 981
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEAQRKAL 177
+ ++ + AK+ +E Q++LD K ++ +QQV LE
Sbjct: 982 MAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS---- 1037
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL 237
EQ + ++ L K+KLE +Q I L + ++ ++ + + E+ L R+ D
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIED- 1096
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKV 297
L Q QK KL+E + +E L+EE + A E L + + E++ E++
Sbjct: 1097 ----EQALGSQLQK--KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 298 KATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAE-IKKLKEQI--- 353
+ +V+ + A +++ ++L E + + A + A+ + +L EQI
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210
Query: 354 LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH 413
+ +Q K+E+ +T + Q A+ + +E ++ KAE+
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Query: 414 KEILDQLESLKLENRHLSEMVMKLE 438
++ Q L+ EN LS + + E
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKE 1295
Score = 74.7 bits (182), Expect = 2e-13
Identities = 101/475 (21%), Positives = 209/475 (44%), Gaps = 77/475 (16%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
LQE + ++ + A K S E H L+ E++ L ++ ++ L ++
Sbjct: 1397 LQEAEEAVEAVNA-KCSSLEKTKHRLQN-------EIEDLMVDVERSNAAAAALDKKQRN 1448
Query: 85 HEKIKQEMTMEYKQ----------ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
+KI E +Y++ E + L EL LK +YE+ + + F+ KN +E
Sbjct: 1449 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE-SLEHLETFKRENKNLQE 1507
Query: 135 DRS--------------EIERLTAKIE----------EFRQKSLDWEKQRLIYQQ-QVSS 169
+ S E+E++ ++E E + SL+ E+ +++ Q + +
Sbjct: 1508 EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ 1567
Query: 170 LEAQ-RKALAEQSEIIQAQLVNRKQKLESVELS------SQSEIQHLSSKLERANDTICA 222
++A+ + LAE+ E ++ N + ++S++ S S++E + K+E
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD-----L 1622
Query: 223 NELEIE-----RLTMRVNDLVGTSMTVLQEQQ-QKEEKLRESEKLLE----------ALQ 266
NE+EI+ R+ V + ++L++ Q Q ++ +R ++ L E LQ
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ 1682
Query: 267 EEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELM 326
E EL+A ++ E A + + E+V+ ++Q+ + + A QL E+
Sbjct: 1683 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVE 1742
Query: 327 EKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR--DIT 384
E +E + E + + + E+ L+ EQ S+ LE MK + ++L R +
Sbjct: 1743 EAVQECRNAEEKAKKAITDAAMMAEE-LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1801
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDK-AVEHKEILDQLESLKLENRHLSEMVMKLE 438
+ KG ++K L A +++ E++ E K + ++ ++ R + E+ + E
Sbjct: 1802 QIALKGGKKQLQK-LEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE 1855
Score = 72.8 bits (177), Expect = 6e-13
Identities = 101/415 (24%), Positives = 175/415 (42%), Gaps = 58/415 (13%)
Query: 44 EGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMT---MEYKQEL 100
E R+ A ET ++ + L SQ E G L +Q++E E + ++T + Y Q+L
Sbjct: 1258 EHRSKAEET-----QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 101 ----KKLHEELCILKRSYEKLQ--KKQMREFRGNTKNHREDRSEIERLTAKIE-EFRQKS 153
++L EE+ LQ + R + E ++E++R+ +K E Q
Sbjct: 1313 EDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 154 LDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ--AQLVNRK-QKLESVELSSQSEIQHLS 210
+E + Q+ LE +K LA++ + + + VN K LE + Q+EI+ L
Sbjct: 1373 TKYETDAI---QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKR 270
+ER+N A + + +L E +QK E ES+ LE+ Q+E R
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDK-----------ILAEWKQKYE---ESQSELESSQKEAR 1475
Query: 271 ELKAALQSQENLIHEA-------RIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQ 323
L L +N E+ + + + LQE++ Q ++ + KQL
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535
Query: 324 ELMEKYEELKRMEA--------------HNNEYKAEI-KKLKEQILQGEQSYSSALEGMK 368
E ME L+ EA N+ KAEI +KL E+ + EQ+ + L +
Sbjct: 1536 EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVD 1595
Query: 369 MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESL 423
+ L E R+ + K D+ + + ++ A A E ++ + L+SL
Sbjct: 1596 SLQTSLDAETRSRNEALRVKKKMEGDLNE-MEIQLSHANRMAAEAQKQVKSLQSL 1649
Score = 61.6 bits (148), Expect = 1e-09
Identities = 76/386 (19%), Positives = 169/386 (43%), Gaps = 51/386 (13%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER- 141
EE ++K+ + + K+L E++ L + LQ + E + N + E ++ +
Sbjct: 854 EEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDLQLQVQAE-QDNLADAEERCDQLIKN 911
Query: 142 ---LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
L AK++E ++ D E+ + LE + L + ++ L K+E
Sbjct: 912 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLA----KVEKE 967
Query: 199 ELSSQSEIQHLSSKLERANDTIC-----------ANELEIERLTM---RVNDLVGTSMTV 244
+ ++++++++L+ ++ ++ I A++ ++ L +VN L + +
Sbjct: 968 KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL 1027
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH 304
Q+ E L + +K+ L+ KR+L+ L+ + I + K++L E++K + +
Sbjct: 1028 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL 1087
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
+E A QL ++L E +A I++L+E+ L+ E++ + +
Sbjct: 1088 NALNARIEDEQALGSQLQKKL--------------KELQARIEELEEE-LEAERTARAKV 1132
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK----AEDKAVEH------- 413
E ++ ++S +E+ +R +M K+ AE QK E+ ++H
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 414 -KEILDQLESLKLENRHLSEMVMKLE 438
K+ D + L + +L + KLE
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLE 1218
Score = 55.1 bits (131), Expect = 1e-07
Identities = 89/407 (21%), Positives = 164/407 (40%), Gaps = 66/407 (16%)
Query: 3 ALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEG--RTH-----ALETCL- 54
AL E + H G + + E ++ +I+ +A K E E R H +L+T L
Sbjct: 1543 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLD 1602
Query: 55 -------------KIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK 101
K E +L + QL ++ +QV+ + + ++ ++ ++
Sbjct: 1603 AETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1662
Query: 102 K---LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
L E + I++R LQ ++ E R + R E +E + S E+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQA-ELEELRAVVEQTERSRKLAE------QELIETS---ER 1712
Query: 159 QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI------------ 206
+L++ Q S + ++K A+ S++ Q ++ Q+ + E ++ I
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQL-QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1771
Query: 207 -QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK-EEKLRESEKLLEA 264
Q S+ LER + E I+ L R+++ ++ ++Q QK E ++RE E LEA
Sbjct: 1772 EQDTSAHLERMKKNM---EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828
Query: 265 LQEEKRELKAALQSQENLIHEARIQKE--------------KLQEKVKATNTQHAVEAIS 310
Q+ E ++ E I E Q E KLQ KVKA Q
Sbjct: 1829 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888
Query: 311 LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE 357
+ + +++ EL E E E+ N+ +A+ + + + L E
Sbjct: 1889 ANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 81.6 bits (200), Expect = 1e-15
Identities = 97/434 (22%), Positives = 198/434 (45%), Gaps = 53/434 (12%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE---------EHEKIKQEMTMEYKQELK 101
E L ++ +E+ LR +L +H +L Q +H +++ + E++
Sbjct: 185 EQQLTMKPEEIVRLREEL--SHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQ 242
Query: 102 KLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIE----EFRQKSLDWE 157
+LH+ L L+ + ++R RG + ++ S ++ KI+ +QK LD
Sbjct: 243 QLHQNLHRLQILCNSAEN-ELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDST 301
Query: 158 KQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAN 217
K SSL A+ K ++ + ++ +++ Q ++S + + Q ++ SK+ A
Sbjct: 302 KM-------CSSLTAEYKHCQQKIKELELEVLKHTQSIKS-QNNLQEKLVQEKSKVADAE 353
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES----EKLLEALQEEKRELK 273
+ I L+++R + + T T + E+QQ EEK++E+ K+ + QEE+++ K
Sbjct: 354 EKI----LDLQRKLEHAHKVCLTD-TCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRK 408
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK 333
Q+ + L + R LQ+K + + ++ A KQL E + E +K
Sbjct: 409 LLYQNVDELHRQVR----TLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVK 464
Query: 334 RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 393
N E ++ KL+++ + Y L+ + + + + ++ HQ+ + + K +
Sbjct: 465 ----SNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLT 520
Query: 394 D----MEKRLRA---EMQKAEDKAVEHKEILDQL----ESLKLENRHLSEMVMKLELGLH 442
+ +KR+ E+ + K + K I DQ+ ++L LE R L E V++ E +H
Sbjct: 521 NEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIH 580
Query: 443 -ERWGFTMLSSLVL 455
+W + + S VL
Sbjct: 581 SNKWTISSIQSRVL 594
Score = 52.0 bits (123), Expect = 1e-06
Identities = 94/467 (20%), Positives = 187/467 (40%), Gaps = 87/467 (18%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE------KIKQEMTMEYKQELKKLH 104
E LK+ +EL+ +S+L + EV L + E + + Q E + ++ KL
Sbjct: 31 EKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIACDLLQRENSELETKVLKLS 90
Query: 105 EELCILKRSYEKLQKKQMREFRGNTKNHRED---------------RSEIERLTAKIEEF 149
+E L ++ L K ++N +D + E E L K+ E
Sbjct: 91 QEFAQL--NHFTLGGKTAPSNLITSENTCKDPESNEPILETEIQSRKEETEELCPKLGER 148
Query: 150 RQKSL------------DWEKQRLIYQQQVSSLEAQRKALAEQSEII---QAQLVNRKQK 194
+QK + + +K+ Q + E + + L + E I + +L + Q
Sbjct: 149 KQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTMKPEEIVRLREELSHINQS 208
Query: 195 L---------------------ESVELSSQSEIQHLSSKLERANDTIC---ANELEIER- 229
L E ++ + Q E+Q L L R +C NEL ER
Sbjct: 209 LLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQLHQNLHRL-QILCNSAENELRYERG 267
Query: 230 ----LTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEAL-------QEEKRELK-AALQ 277
L + L ++ + E + ++KL +S K+ +L Q++ +EL+ L+
Sbjct: 268 QNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLK 327
Query: 278 SQENLIHEARIQKEKLQEKVKATNT-------QHAVEAISLESVSATCKQLSQELMEKYE 330
+++ + +Q++ +QEK K + Q +E ++ TC Q+L EK +
Sbjct: 328 HTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRKLEHAHKVCLTDTCISEKQQLEEKIK 387
Query: 331 ELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKG 390
E + EA + E ++ ++ + Q + ++ + + L Q+ I +
Sbjct: 388 EATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEA 447
Query: 391 SSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKL 437
+ K+L E +K ++ ++E+ ++L L+ E L E ++L
Sbjct: 448 ----LLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRL 490
Score = 48.5 bits (114), Expect = 1e-05
Identities = 69/323 (21%), Positives = 136/323 (42%), Gaps = 49/323 (15%)
Query: 155 DWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ---AQLVNRKQKLESVELSSQSEIQHL-- 209
+W K+R +Q S L+ KAL +SE +Q ++L+ ++ ++ S+S+ L
Sbjct: 12 EWSKEREREKQLASGLDTAEKALKVESEELQKSKSELICLYNEVHNLPGESESKDHFLIA 71
Query: 210 SSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEK 269
L+R N + L++ + ++N T E ++ E L+ E
Sbjct: 72 CDLLQRENSELETKVLKLSQEFAQLNHFTLGGKTAPSNLITSENTCKDPESNEPILETEI 131
Query: 270 RELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAVEAISLESVSATCKQLSQELME 327
+ K + + E R QKE +E VK + + E S ++ ++ Q+L
Sbjct: 132 QSRKEETEELCPKLGE-RKQKEIPEESVKEGSFPREGQKEEGSQQNRDMKDEEKEQQLTM 190
Query: 328 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA--------LEGMKM------EISH 373
K EE+ R+ + E+ + + +LQ + S S+ G K+ E+
Sbjct: 191 KPEEIVRL-------REELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEVQQ 243
Query: 374 LTQELHQRDITIAST-------KGSSSDMEK----------RLRAEMQKAEDKAVEHKEI 416
L Q LH+ I S +G + D+++ +++ E++ A+ K ++ ++
Sbjct: 244 LHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKM 303
Query: 417 LDQLESLKLENRHLSEMVMKLEL 439
SL E +H + + +LEL
Sbjct: 304 ---CSSLTAEYKHCQQKIKELEL 323
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 81.3 bits (199), Expect = 2e-15
Identities = 93/433 (21%), Positives = 197/433 (45%), Gaps = 30/433 (6%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E L+ IQN FL E + + + AH+ + + + + +++ E++L
Sbjct: 634 EEELKDIQNMN----FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 62 K----SLRSQLDVTHKEVGMLHQQVEEHEKIKQEM-TMEYKQELKKLHEELCILKRSYEK 116
+ + + + + + L +V++ + + E + ++++K +E ++ E+
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 117 LQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKA 176
L + + + + R+E LT ++++ + K D + ++ + +
Sbjct: 750 LLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGK 809
Query: 177 LAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSK-----LERAND-TICANELEIERL 230
+ E+++A+L+ K ++V+ Q EI+ L + LE+A +I + E++ L
Sbjct: 810 IKSVEELLEAELLKVANKEKTVQDLKQ-EIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Query: 231 TMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ--SQENLIH-EAR 287
+ + T VL+E KE+ L + K L+ LQEE LKA +Q +Q NL +
Sbjct: 869 LKGKEEQMNTMKAVLEE---KEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 288 IQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIK 347
Q E+L+ +K + L+ + A K+ +L K + L+ ++ N +K++I+
Sbjct: 926 SQFEELEIVLKEKENE-------LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
Query: 348 KLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAE 407
+LK+Q Q S+ E +K+ IS +E+ + S K + K+ Q+ E
Sbjct: 979 QLKQQNYQQASSFPPHEELLKV-ISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVE 1037
Query: 408 DKAVEHKEILDQL 420
+E KE+L +L
Sbjct: 1038 AVELEAKEVLKKL 1050
Score = 67.4 bits (163), Expect = 3e-11
Identities = 107/512 (20%), Positives = 207/512 (40%), Gaps = 109/512 (21%)
Query: 16 GFLTSCEAELQE---LMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTH 72
G LT+ +LQE L+ + A K + T + T + + ++ ++
Sbjct: 325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
Query: 73 KEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH 132
KE + ++ + Q+M M+++Q +++ E+ LK+ + +R+ NT N
Sbjct: 385 KEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ-----ENGILRDAVSNTTNQ 439
Query: 133 REDRSEIE---------RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEI 183
E + E RL ++ E K E Q+ +Q + L+ Q + + E
Sbjct: 440 LESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE 499
Query: 184 IQAQLVNR-------KQKLESVELSSQSEIQHLSSKLERANDTICANEL----------- 225
+Q+ + R +Q L+S ++ ++E+Q L SKL DT+ + +
Sbjct: 500 VQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL---TDTLVSKQQLEQRLMQLMES 556
Query: 226 ------EIERLTMRVNDLVG-------------------TSMTVLQEQ------------ 248
+ E L M+V D++ TS +VL E+
Sbjct: 557 EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
Query: 249 --------------QQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
KEE+L++ + + L+ E ++L+A Q HE EK+Q
Sbjct: 617 KQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL----EKMQ 672
Query: 295 EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 354
+ V + + + +QL E+ K EE K + N K+E++KL Q L
Sbjct: 673 QSVYVKD----------DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL--QTL 720
Query: 355 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHK 414
EQ +E M+ I ++L + + + + E+ L A + E+ ++ K
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNA--IRTENSSLT-K 777
Query: 415 EILDQLESLKLENRHLSEMVMKLELGLHERWG 446
E+ D L++ + + + +V +L+ +HE+ G
Sbjct: 778 EVQD-LKAKQNDQVSFASLVEELKKVIHEKDG 808
Score = 62.0 bits (149), Expect = 1e-09
Identities = 105/493 (21%), Positives = 211/493 (42%), Gaps = 87/493 (17%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCL---KIREQELKSLRSQLDVTHKEVGMLHQQ- 81
+++++Q++ + K + + LET L +E+EL ++R++ KEV L +
Sbjct: 727 KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQ 786
Query: 82 ---------VEEHEKI------------------------KQEMTMEYKQELKKLHEEL- 107
VEE +K+ K++ + KQE+K L EE+
Sbjct: 787 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIG 846
Query: 108 -CILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ 166
L+++ + +++E + K E ++ + A +EE + + K Q++
Sbjct: 847 NVQLEKAQQLSITSKVQELQNLLKGKEE---QMNTMKAVLEEKEKDLANTGKWLQDLQEE 903
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKL-ERANDTICANEL 225
SL+A + +A Q + +A ++ ++LE V ++E++ L + L ER +D +++
Sbjct: 904 NESLKAHVQEVA-QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL--SSKT 960
Query: 226 EIERLTMRVNDLVGTSMTVLQEQQ-QKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
++ + N L + + L++Q Q+ E+LL+ + E ++E+ ++L
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 285 EARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELM--------------EKYE 330
Q++K E+ Q VEA+ LE+ K + + +K +
Sbjct: 1021 AVEHQRKKNNER------QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1074
Query: 331 ELKRMEAHNNEYKAEIKKLKEQ-----ILQGE-QSYSSAL---EGMKMEISHLTQ----- 376
E + + E K KLKE +LQ E + Y S L EG+ ++ +
Sbjct: 1075 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1134
Query: 377 ------ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHL 430
E H+ + S+ SS +RLR+E + E+ E + + +LE ++E
Sbjct: 1135 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1194
Query: 431 SEMVMKLELGLHE 443
V +L+ L+E
Sbjct: 1195 VTEVRELKAQLNE 1207
Score = 54.7 bits (130), Expect = 2e-07
Identities = 78/395 (19%), Positives = 155/395 (39%), Gaps = 38/395 (9%)
Query: 83 EEHEKIK-QEMTMEYKQELKKLHEELCILKRSYEK---LQKKQMREFRGNTKNHREDRSE 138
+E+ ++K ++ + K + E LC++ EK +Q + +G E
Sbjct: 277 KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQE 336
Query: 139 IERLTAKIEEFRQKSLD----------WEKQR-----LIYQQQVSSLEAQRKALAEQSEI 183
++L A ++E + D EK+R + ++ +LE + + +
Sbjct: 337 KDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHV 396
Query: 184 IQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTIC--ANELEIERLTMRVNDLVGTS 241
+ + K + V ++EI HL + D + N+LE ++ + +N L
Sbjct: 397 SYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQ-SAELNKLRQDY 455
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE-------NLIHEARIQKEKLQ 294
++ E +K KL++ E + ++ +LK LQ E + I + + E Q
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ 515
Query: 295 EKVKATNTQHAVEAISLES----VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
+ +++ E SL S + +QL Q LM+ E ++ + +++ +
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 575
Query: 351 EQ--ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAED 408
EQ L+ + + + S L +ELH+ IA E L +E +
Sbjct: 576 EQNEALKAQIQQFHSQIAAQTSASVLAEELHK---VIAEKDKQIKQTEDSLASERDRLTS 632
Query: 409 KAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
K E K+I + LK E + L + + HE
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
Score = 49.7 bits (117), Expect = 6e-06
Identities = 66/315 (20%), Positives = 138/315 (43%), Gaps = 41/315 (13%)
Query: 51 ETCLKI---REQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEEL 107
E LK+ RE+E+ L ++LD V ++ E ++ + + +E K+ LKKL ++
Sbjct: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKV 1054
Query: 108 CILKR--------SYEKLQKKQMREFRGNTK----NHREDRSEIERLTAKIEEFRQKSLD 155
+ +EK K+ M G+ + H+ ++ ++E + KS+
Sbjct: 1055 SVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVL 1114
Query: 156 WEKQRLIY--QQQVSSLEAQRKALAEQS----EIIQAQLVNRKQKLESVELSSQS----- 204
E + ++ Q+ V E + K ++S + +Q+ + +Q+LE + ++
Sbjct: 1115 AETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLR 1174
Query: 205 -EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLE 263
E +HL +LE+A E+ L ++N+ + T E+Q+ L ++++ LE
Sbjct: 1175 REREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE 1234
Query: 264 ALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQ 323
+Q + +KAA +I + + E T+ + + S++ T QL Q
Sbjct: 1235 LIQ--SKIVKAA--GDTTVIENSDVSPE----------TESSEKETMSVSLNQTVTQLQQ 1280
Query: 324 ELMEKYEELKRMEAH 338
L ++L + + H
Sbjct: 1281 LLQAVNQQLTKEKEH 1295
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 80.5 bits (197), Expect = 3e-15
Identities = 100/432 (23%), Positives = 196/432 (45%), Gaps = 46/432 (10%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
E E M Q + ++ + +++ AL+T L + QEL+ ++ E+ L +Q+E
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Query: 84 EHEKIKQ----------EMTMEYKQELKKLHEELCILKRSYEKLQ--KKQMREFRGNTKN 131
+ Q E + +E+K L +E LK+ E LQ + Q++ +T N
Sbjct: 898 NRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVN 957
Query: 132 HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLV-- 189
D E R + + Q++++ K ++ ++VS + E + Q ++V
Sbjct: 958 MNIDTQEQLRNALESLKQHQETINTLKSKI--SEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 190 NRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ 249
++KQ LE+ Q L++ ++ ++ I + +I L N+L +V+ E++
Sbjct: 1016 DKKQDLEA------KNTQTLTADVK--DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 250 QKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI 309
Q + L+E+ ++ QEE R L L+ Q+ ++ + + K + ++ T + A
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 310 SLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKM 369
L+ S ++ Q+L+ EE+ M+ N EI+ LK ++ E + LE M+
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN----EIENLKNELKNKELT----LEHMET 1179
Query: 370 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH-----KEI----LDQL 420
E L Q+L++ + S E+++ E+QK+ + +H +EI L
Sbjct: 1180 ERLELAQKLNENYEEV-----KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234
Query: 421 ESLKLENRHLSE 432
E LK+ + HL E
Sbjct: 1235 EELKIAHIHLKE 1246
Score = 77.0 bits (188), Expect = 3e-14
Identities = 86/467 (18%), Positives = 203/467 (43%), Gaps = 59/467 (12%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
++E +L + I +VA K E E CLK +E+ + LR L E+ + +Q
Sbjct: 1455 QSESDQLKENIKEIVA-KHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 82 VEE-HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIE 140
+E ++K++ ++ QE+ + E+ I + S + + ++++F+ + K IE
Sbjct: 1514 LEAINDKLQNKI-----QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIE 1568
Query: 141 ----RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK-- 194
LT +++E +++ K++ ++ +L+ +R L E ++ I A++ ++K
Sbjct: 1569 SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEY 1628
Query: 195 ----LESVELSSQS--EIQHLSSKLE--------------RANDTICANELEIERLTMRV 234
+ +V + + EI+HL + E R + N E+ +T
Sbjct: 1629 QFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKER 1688
Query: 235 NDLVGTSMTVLQEQQQKEEKLRES-------------------------EKLLEALQEEK 269
+DL T+ E+ Q +E LRE+ +KL + E+
Sbjct: 1689 DDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKT 1748
Query: 270 RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKY 329
E+ + E+ + Q K+QE+++ + + +++ + + + +L
Sbjct: 1749 NEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQ 1808
Query: 330 EELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTK 389
++L+ A E E+K + Q++ ++ + + + E+ L +++ + +T++ +
Sbjct: 1809 KDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVS-EMEQLKKQIKDQSLTLSKLE 1867
Query: 390 GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 436
+ ++ ++L +++ + E + E+LKLE L E + +
Sbjct: 1868 IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914
Score = 64.3 bits (155), Expect = 2e-10
Identities = 95/499 (19%), Positives = 215/499 (43%), Gaps = 101/499 (20%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIR--------EQELKSL---RSQLDVT 71
+E QE M +++++ ++ + T A ++R ++E+KSL R L
Sbjct: 1299 SETQETMNELELLTEQSTTK-DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTI 1357
Query: 72 HKEVGMLHQQVEEH----------EKIKQEMTMEYKQ---ELKKLHEEL--------CIL 110
+ + + H Q++EH + KQE ++ K+ E K+ E+ +L
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417
Query: 111 KRSYEKLQ-KKQMREFRGNTKNHREDRSEIERLTA-----------KIEEFRQKSLDWEK 158
+ E L K+++E K+ +++ +++RL I+E K L+ E+
Sbjct: 1418 RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE 1477
Query: 159 QRLI--------------YQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL----ESVEL 200
+ + + +S E + + +Q E I +L N+ Q++ E +
Sbjct: 1478 ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNI 1537
Query: 201 SSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEK 260
SE+Q ++L++ + A + ++ + ++ +L +E Q ++ E ++
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR 1597
Query: 261 LLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT---------------NTQHA 305
+ EALQ E+ +LK ++ + ++ + + +EK + +K T Q
Sbjct: 1598 VQEALQIERDQLK---ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
Query: 306 VEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL- 364
+ ++LE++ +L+Q L E EE++ + ++ ++ + LK + Q +++ +
Sbjct: 1655 TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT 1714
Query: 365 ----EGMKMEISHLTQELHQRDI-----TIASTKGSSSDMEKRLR--AEMQKAEDKAVEH 413
+ +++I H+ + HQ I ++ S+M+K L + KA+D ++
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ- 1773
Query: 414 KEILDQLESLKLENRHLSE 432
E L++ + HL E
Sbjct: 1774 -------EELRIAHMHLKE 1785
Score = 63.9 bits (154), Expect = 3e-10
Identities = 99/496 (19%), Positives = 209/496 (42%), Gaps = 93/496 (18%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
E+QE + +++ + K + E R L+T E+E + +L T +EV L Q+ +
Sbjct: 881 EVQERLNEMEQL----KEQLENRDSTLQTV----EREKTLITEKLQQTLEEVKTLTQEKD 932
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCI-------LKRSYEKLQKKQ--------------- 121
+ +++++ + +E Q +H+ + + L+ + E L++ Q
Sbjct: 933 DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVS 992
Query: 122 ----MREFRGNTKNHREDR------------SEIERLTAKIE-----EFRQKSLDWEKQR 160
M E G TK+ + + + LTA ++ E ++K +++
Sbjct: 993 RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK 1052
Query: 161 LIYQQQVSSLEAQRKAL-AEQSEIIQAQLVNRKQ-KLESVELSSQSEI-----QHLSSK- 212
QQ + S+ A+++ L + E I+ + N+++ +L EL Q EI H K
Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112
Query: 213 --LERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL--------- 261
L R D + E +++ + ++ + + V +E + ++K+ E E L
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKEL 1172
Query: 262 -LEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQ 320
LE ++ E+ EL L + +++ L+E K+ T+ + + AT Q
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQ 1232
Query: 321 LSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG---EQSYSSALEGMKMEISHLTQE 377
+EL + LK + +E + + + QI+ E+S++ E ++ + H QE
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE--EIPVLHEEQE 1290
Query: 378 LHQRDITIASTKGSSSDME--------------KRLRAEMQKAEDKAVEHKEILDQLESL 423
L ++ T+ + +++E R+ E + +K E +E +++SL
Sbjct: 1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQE---EIKSL 1347
Query: 424 KLENRHLSEMVMKLEL 439
E +L + LE+
Sbjct: 1348 TKERDNLKTIKEALEV 1363
Score = 62.4 bits (150), Expect = 9e-10
Identities = 99/465 (21%), Positives = 212/465 (45%), Gaps = 57/465 (12%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETC---LKIREQELKSLRSQLDVTHKEVGMLHQ 80
E QE + ++ +V+ K + LE L+ + QELK+ QL K+V +
Sbjct: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQK 1844
Query: 81 QVEEHEKIKQEMTMEYKQELKKLH-EELCILKRSYEKLQK-KQMREFRGNTKNHRED-RS 137
+V E E++K+++ + L KL E L + ++ +E L++ K + + R N + E +
Sbjct: 1845 KVSEMEQLKKQI-KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903
Query: 138 EIERLTAKIEEFRQKSLDWEKQ----RLIYQQQVSSLEAQRKALAE---QSEIIQAQLVN 190
E ++L ++E + + L+ +++ R++ ++ +++ R+ ++E Q IQ L
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963
Query: 191 RKQKLE-SVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ 249
K +L+ ++ + E+Q L K + NE+E + +L + +V +
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL--SMQSVRMDNF 2021
Query: 250 QKEEKLRESEKLLEALQEEKRELKAALQS------------QENLIHEARIQKEKLQEKV 297
Q +KL ES + + + +E+ EL+ +S +E + + + + K ++++
Sbjct: 2022 QLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRL 2081
Query: 298 KATNTQHAVEAISLESVSATCKQLSQ---ELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 354
+ QH E SL + K+L + E+ + YE L R+ + + EI+ KE +
Sbjct: 2082 LSDGQQHLTE--SLREKCSRIKELLKRYSEMDDHYECLNRLSL---DLEKEIEFQKELSM 2136
Query: 355 QGEQSYS-------------SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRA 401
+ + + S +A + ME + ++L + + TK E +
Sbjct: 2137 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKL--KYVLSYVTKIKEEQHESINKF 2194
Query: 402 EMQKAEDKAVEHKEILDQLESLK----LENRHLSEMVMKLELGLH 442
EM D+ + KE+L +++ L+ + +R L ++ + + LH
Sbjct: 2195 EMDFI-DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLH 2238
Score = 55.1 bits (131), Expect = 1e-07
Identities = 97/443 (21%), Positives = 187/443 (42%), Gaps = 77/443 (17%)
Query: 44 EGRTHALET----CLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQE 99
+G+ H E+ C +I+E L S++D ++ + L +E+ + ++E++M K
Sbjct: 2084 DGQQHLTESLREKCSRIKE--LLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKAN 2141
Query: 100 L----------KKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI--E 147
L +KL + ++ KK TK E I + E
Sbjct: 2142 LSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDE 2201
Query: 148 EFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEI--------------------IQAQ 187
+QK L + Q L V S E + L + ++ Q
Sbjct: 2202 VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQV 2261
Query: 188 LVNRKQKLESVE--LSSQSEIQHLSSKLERANDTIC-ANELEIERLTMRVN---DLVGTS 241
L NRK+ + +E L+++ +I+ L + +++ ND IC N R+ +N + S
Sbjct: 2262 LSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERS 2321
Query: 242 MTVLQEQQQKEEKLRE-SEKLLEALQEEKRELKAALQ----SQEN-----LIHEARIQKE 291
T+ +E +Q + L+E +EKL + Q K L + Q +Q+N ++ E
Sbjct: 2322 ATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTE 2381
Query: 292 KLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE 351
K++E N+ H + ++ S K + +EL + + +++A +E ++K KE
Sbjct: 2382 KIRE---LENSLHEAKESAMHKESKIIK-MQKELEVTNDIIAKLQAKVHESNKCLEKTKE 2437
Query: 352 --QILQ-----GEQSYSSALEGMKMEISHLTQE----LHQRDITIASTKGSSSDMEKRLR 400
Q+LQ G + Y +E +KM++ + E + + I++TK + ++ +R
Sbjct: 2438 TIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIR 2497
Query: 401 ------AEMQKAEDKAV--EHKE 415
Q+A+D +V EH +
Sbjct: 2498 LLRENLRRSQQAQDTSVISEHTD 2520
Score = 53.1 bits (126), Expect = 5e-07
Identities = 74/381 (19%), Positives = 157/381 (41%), Gaps = 55/381 (14%)
Query: 109 ILKRSYEKLQ--KKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ 166
+LKR +++ KKQ+ E T+ ++ ++ +L E++ L+ + Q
Sbjct: 344 LLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLL-------------EEKDLLQKVQ 390
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQK---------LESVELSSQSEIQHLSSKLERAN 217
+E + L S + Q + K+K + ++ S+ ++ ++ + +
Sbjct: 391 NEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKT 450
Query: 218 DTICANEL-EIERLTMRVNDLVGTSMTVLQE-QQQKEEKLRESEKLLEALQEEKRELKAA 275
+ N L EI+ +D+ ++ L E + KL E + + EL +
Sbjct: 451 HKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENI-------ESELNSL 503
Query: 276 LQSQENLI---HEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEEL 332
+NL+ + R +KE+++ K+K N EA+ ++ QL E+ +
Sbjct: 504 RADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV 563
Query: 333 KRMEAHNNEY------KAEIKKLKEQILQGEQSY--SSALEGMKMEISH----------L 374
K E +N + K E+ + KE ++ Q Y S LE +KM++S+ +
Sbjct: 564 KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
Q L + K S+ + +K ++ A +K++ + ++ + + +M
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683
Query: 435 MKLELGLHERWG-FTMLSSLV 454
+ LE L + T L+SL+
Sbjct: 684 VDLEKELQSAFNEITKLTSLI 704
Score = 52.0 bits (123), Expect = 1e-06
Identities = 90/435 (20%), Positives = 183/435 (42%), Gaps = 54/435 (12%)
Query: 22 EAELQELMKQIDIM-VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQ 80
E ++++L + ID + + K + ++E ++++ + LD + + +
Sbjct: 588 EDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSE 647
Query: 81 QVEEHEKIKQEMTMEYKQ---ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
+E EK+K E+ YKQ +++ +L K+ L+K+ F +
Sbjct: 648 NLELKEKMK-ELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAF-----------N 695
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
EI +LT+ I+ K L + +LE + K Q E+ + N + E
Sbjct: 696 EITKLTSLIDGKVPKDL------------LCNLELEGKITDLQKELNKEVEENEALREEV 743
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
+ LS E++ L S++ER I E+ +T + L V+ ++ + + L E
Sbjct: 744 ILLS---ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS---EVVHKESRVQGLLEE 797
Query: 258 SEKLLEALQEEKRELKAALQSQENL--IHEARIQKEKL-QEKVKATNTQHAVEAISLESV 314
K + L + K+ Q +N +H QK K+ E+ + N + + +
Sbjct: 798 IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
++ L EL K +EL+ E E+++LKEQ+ ++ S L+ ++ E + +
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL----ENRDSTLQTVEREKTLI 913
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE------------HKEILDQLES 422
T++L Q+ + T D K+L+ +Q D+ +++ + LES
Sbjct: 914 TEKL-QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972
Query: 423 LKLENRHLSEMVMKL 437
LK ++ + K+
Sbjct: 973 LKQHQETINTLKSKI 987
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 80.1 bits (196), Expect = 4e-15
Identities = 93/474 (19%), Positives = 206/474 (43%), Gaps = 56/474 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ--LDVTHKEVGMLH 79
E EL+E K+I ++ W E K+REQE K R + L KE+
Sbjct: 240 EEELREQEKKIR---KQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQE 296
Query: 80 QQVEEHEKIKQEMTMEYKQELK------KLHEELCILKRSYEKL--QKKQMREFRGNTKN 131
+++ E +K++++ +QE K K+ E+ + R E+L Q+KQMRE ++
Sbjct: 297 KELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 356
Query: 132 HREDR-SEIERLTAKIEEFRQKSLDWEKQRLIYQQQ-----VSSLEAQRKALAEQSEIIQ 185
E + ERL K E R++ WE++ + +++ + + + + EQ E +Q
Sbjct: 357 QEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQ 416
Query: 186 AQLVN----RKQKLESVELSSQSEIQHLSSKLERANDTICANELEI-------------- 227
Q N +++ + L Q E K++ + I E +I
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 476
Query: 228 -ERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENL 282
+ D + +++Q+QK EE++ E ++ L +E RE K Q +E +
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKM 536
Query: 283 IHEARIQKEK-----LQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEA 337
E + Q+++ +EK++ E + ++ +++ E+ E+++ E
Sbjct: 537 REEKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMREQEE 595
Query: 338 HNNEYKAEIKKLKEQILQGEQSYSSALEGMKME-----ISHLTQELHQRDITIASTKGSS 392
E + ++++ +E++ + E+ E KM+ + +++ +++ + +
Sbjct: 596 KMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655
Query: 393 SDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHERWG 446
+ E+++R + +K + + +++ +Q E ++ + + E K+ + WG
Sbjct: 656 REQEEKMREQEEKMQG---QEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWG 706
Score = 75.9 bits (185), Expect = 8e-14
Identities = 86/433 (19%), Positives = 195/433 (45%), Gaps = 27/433 (6%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV--E 83
+++ +Q + M ++ WE E K+R+QE + + KE M Q+ E
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDR--SEIER 141
+ EK+++E + ++ KK+ EE ++ EK+QK++ + K ++ R + E+
Sbjct: 384 QEEKMQEEERIRERE--KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 441
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQ-----QVSSLEAQRKALAEQSEIIQAQ--LVNRKQK 194
L + + Q+ WE++ I Q Q + Q K ++ ++ + + + +++QK
Sbjct: 442 LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 501
Query: 195 LESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK 254
+ E + + L K ER + + E + + +E+ ++EE+
Sbjct: 502 MWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEER 561
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESV 314
+RE EK + +E RE + +Q QE + E Q+EK+ E+ + Q E E
Sbjct: 562 MREREKKMREEEEMMREQEEKMQEQEEKMRE---QEEKMWEQEEKMQEQ---EEKMWEQE 615
Query: 315 SATCKQLSQELMEKYEELK-RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISH 373
+Q ++ M++ EE+ E E + ++ + +E++ + E+ E M+ +
Sbjct: 616 EKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ--- 672
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQK---AEDKAVEHKEILDQLESLKLENRHL 430
+++ +++ + + + E+++R + +K E+K +E + E ++ + +
Sbjct: 673 -EEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERI 731
Query: 431 SEMVMKLELGLHE 443
+ K++ L E
Sbjct: 732 RDQKEKMQERLPE 744
Score = 67.4 bits (163), Expect = 3e-11
Identities = 91/437 (20%), Positives = 195/437 (44%), Gaps = 51/437 (11%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
AELQE ++ + +KSE + L ++E + K R++ + + L +++
Sbjct: 190 AELQEKLR----LAESEKSEIQ---------LNVKELKRKLERAKFLLPQVQTNTLQEEM 236
Query: 83 -EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ E+++++ KQE K +E + R E ++Q + R K RE E+
Sbjct: 237 WRQEEELREQEKKIRKQEEKMWRQEERL--REQEGKMREQEEKMRRQEKRLREQEKELRE 294
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
++ E QK L +++++ Q+Q + Q + + EQ E ++ ++++L E
Sbjct: 295 QEKELRE--QKKLREQEEQM--QEQEEKMWEQEEKMREQEE----KMWRQEERLWEQEKQ 346
Query: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261
+ + Q + + ER + L + MR + M +E+ Q+EE++RE EK
Sbjct: 347 MREQEQKMRDQEERMWEQ--DERLREKEERMREQE----KMWEQEEKMQEEERIREREKK 400
Query: 262 LEALQEEKRELKAALQSQENLIHEAR----------IQKEKLQEKVKATNTQHAV----- 306
+ +E RE + +Q QE + E QKEKL E+ K + +
Sbjct: 401 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460
Query: 307 EAISLESVSATCKQL--SQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
+ E + K++ +++ E+ +++ E + + ++ +E++ + ++
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE 520
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSS-DMEKRLRAE--MQKAEDKAVEHKEIL-DQL 420
E M+ + QE R+ + + D E+++R E M++ E K E +E++ +Q
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 580
Query: 421 ESLKLENRHLSEMVMKL 437
E ++ + + E K+
Sbjct: 581 EKMQEQEEKMREQEEKM 597
Score = 62.8 bits (151), Expect = 7e-10
Identities = 78/403 (19%), Positives = 172/403 (42%), Gaps = 51/403 (12%)
Query: 48 HALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEEL 107
H+ E K Q ++LR +++ + +L Q K + E + Y Q+
Sbjct: 67 HSPEDEKKASHQHQEALRREIEAQDHTIRILTCQ-----KTELETALYYSQDAA------ 115
Query: 108 CILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQV 167
R +E + ++ G + E++R + + + +K+ D + L ++
Sbjct: 116 ----RKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKA-DRYIEELTKERDA 170
Query: 168 SSLEAQRKALA-EQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE 226
SLE R + E+ + A+L + + ES + Q ++ L KLERA + +
Sbjct: 171 LSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN 230
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
T+ +E ++EE+LRE EK + +E+ + L+ QE + E
Sbjct: 231 ----------------TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE- 273
Query: 287 RIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQE--LMEKYEELKRMEAHNNEYKA 344
Q+EK++ + K Q + + K+L ++ L E+ E+++ E E +
Sbjct: 274 --QEEKMRRQEKRLREQE-------KELREQEKELREQKKLREQEEQMQEQEEKMWEQEE 324
Query: 345 EIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE-- 402
++++ +E++ + E+ L + ++ Q++ ++ + + E+R+R +
Sbjct: 325 KMREQEEKMWRQEE----RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 380
Query: 403 MQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHERW 445
M + E+K E + I ++ + ++ E + E K++ W
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 423
Score = 38.9 bits (89), Expect = 0.010
Identities = 37/182 (20%), Positives = 87/182 (47%), Gaps = 12/182 (6%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
E +E+M++ + K E E + E K+ EQE K + + +E M Q+ E
Sbjct: 571 EEEEMMREQE----EKMQEQEEKMREQEE--KMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILK---RSYEKLQKKQMREFRGNTKNHREDRSEIE 140
+ + ++EM E ++++++ E++ + R E+ ++Q + +G + RE +++
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ 684
Query: 141 RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ---RKALAEQSEIIQAQLVNRKQKLES 197
K+ E +K E++ ++++ E + ++ + E+ E I+ Q +++L
Sbjct: 685 GQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744
Query: 198 VE 199
E
Sbjct: 745 HE 746
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.324
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,187,366
Number of Sequences: 37866
Number of extensions: 657544
Number of successful extensions: 16021
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 525
Number of HSP's successfully gapped in prelim test: 1227
Number of HSP's that attempted gapping in prelim test: 5210
Number of HSP's gapped (non-prelim): 5535
length of query: 475
length of database: 18,247,518
effective HSP length: 106
effective length of query: 369
effective length of database: 14,233,722
effective search space: 5252243418
effective search space used: 5252243418
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.