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Search of human proteins with 109255226
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
(495 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 950 0.0
gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] 928 0.0
gi|109255236 centrosomal protein 63 isoform d [Homo sapiens] 850 0.0
gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] 828 0.0
gi|116812628 coiled-coil domain containing 67 [Homo sapiens] 222 5e-58
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 97 3e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 97 4e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 97 4e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 97 4e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 97 4e-20
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 95 1e-19
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 95 1e-19
gi|31982906 cingulin-like 1 [Homo sapiens] 95 2e-19
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 91 2e-18
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 91 2e-18
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 91 2e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 91 2e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 88 2e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 88 2e-17
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 87 3e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 87 3e-17
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 87 5e-17
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 87 5e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 84 2e-16
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 84 3e-16
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 83 5e-16
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 83 7e-16
gi|55770834 centromere protein F [Homo sapiens] 83 7e-16
gi|118498368 kinectin 1 isoform c [Homo sapiens] 82 9e-16
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 82 9e-16
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 950 bits (2455), Expect = 0.0
Identities = 495/495 (100%), Positives = 495/495 (100%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY
Sbjct: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
Query: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL
Sbjct: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
Query: 421 ESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 480
ESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL
Sbjct: 421 ESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 480
Query: 481 KRESEKTVRQFTALK 495
KRESEKTVRQFTALK
Sbjct: 481 KRESEKTVRQFTALK 495
>gi|109255239 centrosomal protein 63 isoform b [Homo sapiens]
Length = 541
Score = 928 bits (2398), Expect = 0.0
Identities = 495/541 (91%), Positives = 495/541 (91%), Gaps = 46/541 (8%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAI----------------------------------------------SLESV 314
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 435 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 494
MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL
Sbjct: 481 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 540
Query: 495 K 495
K
Sbjct: 541 K 541
>gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
Length = 475
Score = 850 bits (2195), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY
Sbjct: 301 NTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
Query: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL
Sbjct: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
Query: 421 ESLKLENRHLSEMVMKLELGLHE 443
ESLKLENRHLSEMVMKLELGLHE
Sbjct: 421 ESLKLENRHLSEMVMKLELGLHE 443
>gi|22095367 centrosomal protein 63 isoform a [Homo sapiens]
Length = 703
Score = 828 bits (2139), Expect = 0.0
Identities = 451/536 (84%), Positives = 462/536 (86%), Gaps = 56/536 (10%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAI----------------------------------------------SLESV 314
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 435 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
MKLELGLHE I+ L+E + + L +L + ++L+++ T Q
Sbjct: 481 MKLELGLHEAK-------EISLADLQENYIEA---LNKLVSENQQLQKDLMNTKSQ 526
Score = 138 bits (347), Expect = 1e-32
Identities = 136/512 (26%), Positives = 228/512 (44%), Gaps = 70/512 (13%)
Query: 22 EAELQELMKQIDIMVA------HKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEV 75
E E++ L +++ +V ++ + E + E L+ ++E + L++ L +
Sbjct: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ---SQE 280
Query: 76 GMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG-------- 127
++H+ + EK+++++ Q H I R +KK + +G
Sbjct: 281 NLIHEARIQKEKLQEKVKATNTQ-----HAVEAIRPREESLAEKKYTSQGQGDLDSVLSQ 335
Query: 128 -NTKNHRED--RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
N + ED ++E+ L +E ++ + +++ +EA + + +
Sbjct: 336 LNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 395
Query: 185 QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTV 244
+ Q++ +Q S + EI HL+ +L + + TI + + + R+
Sbjct: 396 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLR--------- 446
Query: 245 LQEQQQKEEKLRESEKLL---EALQEEKRELKAALQSQENLIHEAR-IQKEKLQEK-VKA 299
E Q+ E+K E +++L E+L+ E R L + E +HEA+ I LQE ++A
Sbjct: 447 -AEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEA 505
Query: 300 TNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQS 359
N + + + T QL ++ R+ + E K + + G+
Sbjct: 506 LNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHR 565
Query: 360 YSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 419
+ +G+K E H +LH S +G +SD + + + +
Sbjct: 566 H----DGIKTE--HYKTDLH-------SPRGQASDSINPMSRVLSPLSPQ-ISPCSSTRS 611
Query: 420 LESLKLENRH----------------LSEMVMKLELGLHECSLPVSPLGSIATRFLEEEE 463
L S L H +SE + E + CSLPVSPLGSIATRFLEEEE
Sbjct: 612 LTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEE 671
Query: 464 LRSHHILERLDAHIEELKRESEKTVRQFTALK 495
LRSHHILERLDAHIEELKRESEKTVRQFTALK
Sbjct: 672 LRSHHILERLDAHIEELKRESEKTVRQFTALK 703
>gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
Length = 604
Score = 222 bits (566), Expect = 5e-58
Identities = 156/497 (31%), Positives = 271/497 (54%), Gaps = 42/497 (8%)
Query: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
Query: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
Query: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
Query: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 181 FQKQAQSYQTQLNGKKQCLE----DSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Query: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QE 295
+ + + E Q+ ++L+ ++ +A++ E+K+ LQS+++L+ +++ +L +E
Sbjct: 237 IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
Query: 296 KVKATNTQHA------VEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 349
+K Q+A +E+ L S+ +E K +EL + ++ E+ K+
Sbjct: 297 LLKIGECQNAQGNKTRLESSYLPSI--------KEPERKIKELFSVMQDQPNHEKELNKI 348
Query: 350 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
+ Q+ Q E+ ++S E M+ EIS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E
Sbjct: 349 RSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKM 408
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI 469
+ K + ++++ EN HL M+ L+ G + ++ F E+ R H
Sbjct: 409 LAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEY-----------MSMDFTNREQSR-HTS 456
Query: 470 LERLDAHIEELKRESEK 486
+ +L E L+ + K
Sbjct: 457 INKLQYENERLRNDLAK 473
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 97.4 bits (241), Expect = 3e-20
Identities = 108/501 (21%), Positives = 220/501 (43%), Gaps = 49/501 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + KK E E H LE ++ E+ + L+++ + + L +Q
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQ------MREFRGNTKNH 132
+EE E +Q++ +E + +LKKL EE IL+ KL K++ + EF N
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 133 REDRSEIERLTAK----IEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
E + +L K I + ++ EKQR ++ LE L++Q +QAQ+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + + + + N + +I L ++++L + +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMAL----KKIRELESQISELQEDLESERASR 1127
Query: 249 QQKEEKLRESEKLLEALQEEKRELKAALQSQENL----IHEARIQKEKLQEKVKATNTQH 304
+ E++ R+ + LEAL+ E + + +Q+ L E I K+ L+E+ K Q
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ- 1186
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYK-------AEIKKLKEQILQGE 357
++ + Q +EL E+ E+ KR++A+ + K E+ + +LQG+
Sbjct: 1187 ------IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240
Query: 358 QSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE-------MQKAEDKA 410
+ ++ ++ L + ++ + + +D +L+ E + +++ K+
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGE----RVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 411 VEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI- 469
+ + LES + + L + + +L L V + LEEEE H++
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 470 --LERLDAHIEELKRESEKTV 488
+ L A + ++K++ E +V
Sbjct: 1357 KQIATLHAQVADMKKKMEDSV 1377
Score = 80.5 bits (197), Expect = 3e-15
Identities = 107/504 (21%), Positives = 214/504 (42%), Gaps = 46/504 (9%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVT------------ 71
+++EL QI + +SE R A + + E EL++L+++L+ T
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGE-ELEALKTELEDTLDSTAAQQELRS 1163
Query: 72 --HKEVGMLHQQVEE----HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK-KQMRE 124
+EV +L + +EE HE QEM ++ Q +++L E+L KR L+K KQ E
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
N + + ++ E ++K ++ + Q L Q + + E R LA++ +
Sbjct: 1224 ---NERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL--QVKFNEGERVRTELADKVTKL 1278
Query: 185 QAQLVNRKQKLESVELSSQS---EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTS 241
Q +L N L + S + L S+L+ + + + L+ ++ +
Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK 1338
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ ++ +++EE EK + L + ++K ++ + A K KLQ+ ++ +
Sbjct: 1339 NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLS 1398
Query: 302 TQHAVEAISLESVSATCKQLSQELMEKYEEL--KRMEAHNNEYKAEIKKLKEQILQGEQS 359
+H + + + + T +L QEL + +L +R A N E K +K +Q+L E++
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK---QKKFDQLLAEEKT 1455
Query: 360 YSSALEGMKMEISHLTQELHQRDITIA-------STKGSSSDMEKRLRAEMQKAEDKAVE 412
S+ + +E + +++A K + K+ R EM ED
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM---EDLMSS 1512
Query: 413 HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRF---LEEEELRSHHI 469
++ + L+ R L + V +++ L E + R L+ + +
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572
Query: 470 LERLDAHIEELKRESEKTVRQFTA 493
L+ D EE K++ + VR+ A
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEA 1596
Score = 72.0 bits (175), Expect = 1e-12
Identities = 100/462 (21%), Positives = 194/462 (41%), Gaps = 72/462 (15%)
Query: 22 EAELQELMKQI-----DIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVG 76
+AEL+ L KQ D+M + K + H LE + EQ+++ +++QL+ E+
Sbjct: 1492 KAELERLNKQFRTEMEDLMSS--KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDR 136
E Q M +++++L+ E+ +K +Q+RE ++ R+ R
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQ----SEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 137 S-----------EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
S +++ L A I+ + + KQ Q Q+ + E I
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
AQ ++KL+S+E +E+ L +L A + E + L + + G L
Sbjct: 1666 AQAKENEKKLKSME----AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721
Query: 246 QEQQQKEEKLRESEKLLEALQEEK-----RELKAALQ--------------SQENLIHEA 286
+E+++ E ++ + E+ LE Q R KA LQ +Q+N
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQ 1781
Query: 287 RIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI 346
+++++ + KVK + V++ S++A +++Q + E K +A + +
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 347 KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKA 406
KKLK+ +LQ + +A E ++ AST+ K+L+ ++++A
Sbjct: 1842 KKLKDVLLQVDDERRNA-------------EQYKDQADKASTR------LKQLKRQLEEA 1882
Query: 407 EDKAVE--------HKEILDQLESLKLENRHLSEMVMKLELG 440
E++A +E+ D E+ NR +S + KL G
Sbjct: 1883 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRG 1924
Score = 67.4 bits (163), Expect = 3e-11
Identities = 90/431 (20%), Positives = 177/431 (41%), Gaps = 91/431 (21%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + ++L++Q+ M A + E + R+ A+ K+ E +LK L + +D +K
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-EMDLKDLEAHIDSANKN------- 1632
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
E IKQ L+KL ++ K MRE + R+ E
Sbjct: 1633 --RDEAIKQ---------LRKLQAQM-----------KDCMRELD-------DTRASREE 1663
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLE-AQRKALAEQSEIIQ---------AQLVNR 191
+ A+ +E +K E + + Q+++++ E A+R+A E+ E+ A +
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
K++LE+ + E++ E ND + L+I D + T + + + QK
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI--------DQINTDLNLERSHAQK 1775
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLI---HEARIQ--KEKLQEKVKATNTQHAV 306
E R+ L+ + +ELK LQ E + ++A I + K+ + + + +
Sbjct: 1776 NENARQQ------LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEY---KAEIKKLKEQILQGEQSYSSA 363
+ + V T K+L L++ +E + E + ++ +K+LK Q+ + E+ A
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889
Query: 364 -----------------LEGMKMEISHLTQELHQRDITIA-----STKGSSSDMEKRLRA 401
+ M E+S L +L + D+ + KG+ ++ +
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDG 1949
Query: 402 EMQKAEDKAVE 412
+ AE K E
Sbjct: 1950 KADGAEAKPAE 1960
Score = 63.5 bits (153), Expect = 4e-10
Identities = 75/357 (21%), Positives = 161/357 (45%), Gaps = 28/357 (7%)
Query: 152 KSLDWEKQRLIYQQ----QVSSLEAQRKALAEQS-EIIQAQLV--NRKQKLESVELSSQS 204
K +W+ RL + QVS E + A E+ ++ + QL NR ++E+++ +
Sbjct: 821 KLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA 880
Query: 205 EIQHLSSKLERANDTICANELEIE-RLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLE 263
E L +L+ A +CA E+ RLT + +L + +++EE+ + + +
Sbjct: 881 EKLQLQEQLQ-AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 264 ALQEEKRELKAALQSQENLIHEARIQK-------EKLQEKVKATNTQHAVEAISLESVSA 316
+Q+ +EL+ L+ +E+ + +++K +KL+E+ Q+ A + +
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 317 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE---QSYSSALEGMKMEISH 373
+ + L E+ E+ K + N+++A I L+E++ + E Q ++ + +
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEM 433
L+ ++ + IA K + E+ L+A + + E++A + L ++ L+ + L E
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 434 VMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLD--AHIEELKRESEKTV 488
+ ++ LG EE E + + LD A +EL+ + E+ V
Sbjct: 1120 LESERASRNKAEKQKRDLG-------EELEALKTELEDTLDSTAAQQELRSKREQEV 1169
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 96.7 bits (239), Expect = 4e-20
Identities = 102/491 (20%), Positives = 226/491 (46%), Gaps = 38/491 (7%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1144 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1203 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1255
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVE----HKEI 416
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ +E
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 417 LDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAH 476
L+ E L+ N+ L + L + V L + R LE + +E +
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK-SKRALETQ-------MEEMKTQ 1547
Query: 477 IEELKRESEKT 487
+EEL+ E + T
Sbjct: 1548 LEELEDELQAT 1558
Score = 85.9 bits (211), Expect = 8e-17
Identities = 98/500 (19%), Positives = 219/500 (43%), Gaps = 52/500 (10%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKI--REQELKSL----------- 64
L E + +L ++ +++ ++E E A E +++ ++QEL+ +
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 65 ---RSQLDVTHKEVGM----LHQQVEEHEKIKQEMTME---YKQELKKLHEELCILKRSY 114
QL K++ L +Q+EE E +Q++ +E + ++KKL +E+ ++
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR 174
KL K+ + E+R I LT + E +K+ + K + ++ +S LE +
Sbjct: 995 NKLSKE---------RKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 175 KALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
K + E + +L K+KLE +I L +++ + E E++ R+
Sbjct: 1044 K----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 235 NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
+D + L++ ++ E + + L E L E+ A + + +L E K +L+
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 295 EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 354
+ + +T TQ + A + V+ K L +E +++ M + + E+ + EQ
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 355 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-- 412
+ + + + ++ E + L EL + K +K+L A++Q+ + K +
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 413 --HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHIL 470
E+ D++ L+ E ++ M+ + E + + V+ S++++ + +EL
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA---SLSSQLQDTQELLQEETR 1329
Query: 471 ERLDAHIEELKRESEKTVRQ 490
++L+ + + E E+ Q
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQ 1349
Score = 82.8 bits (203), Expect = 7e-16
Identities = 97/421 (23%), Positives = 185/421 (43%), Gaps = 36/421 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1502 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1614
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1850
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEC 444
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 445 S 445
+
Sbjct: 1911 T 1911
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/432 (22%), Positives = 197/432 (45%), Gaps = 50/432 (11%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1021
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI 469
A +E+ +QLE K +L + LE + + G + R L + + H
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------GEL--RVLGQAKQEVEHK 1253
Query: 470 LERLDAHIEELK 481
++L+A ++EL+
Sbjct: 1254 KKKLEAQVQELQ 1265
Score = 70.9 bits (172), Expect = 3e-12
Identities = 97/502 (19%), Positives = 217/502 (43%), Gaps = 49/502 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1258 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1377 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEIKKLKEQ 352
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E++ ++Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 353 ---ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
++ L+ ++++ + + + + D ++ L ++
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPL-----GSIATRFLEEEEL 464
KE + +SL+ + L E + E + L L S++ R ++E
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 465 RSHHILERLDAHIEELKRESEK 486
R RL+A I +L+ E E+
Sbjct: 1732 R------RLEARIAQLEEELEE 1747
Score = 67.4 bits (163), Expect = 3e-11
Identities = 105/535 (19%), Positives = 223/535 (41%), Gaps = 94/535 (17%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ EA++++L +I +M + + + L K+ E+ + L + L ++ L
Sbjct: 975 TAEAKIKKLEDEILVM--------DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 80 QQVEEHEKIKQEMTMEYK------QELKKL-----------HEELCILK----------- 111
+ +HE + E+ + K QEL+KL HE++ L+
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 112 RSYEKLQK----------------KQMREFRGNTKNHRED------------------RS 137
+ E+LQ K++RE G+ + +ED
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E+E L ++E+ + ++ R +Q+V+ L +KAL E++ +AQ+ +QK
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQK--- 1200
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
+ E+ + +RA + N+ +E+ DL G + Q +Q+ E K ++
Sbjct: 1201 -HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA---DLAGELRVLGQAKQEVEHKKKK 1256
Query: 258 SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSAT 317
E ++ LQ + + + A + +H+ + + E + + + A + S+S+
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 318 CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI---LQGEQSYSSALEGMKMEISHL 374
+ + L E+ + + + + E L++Q+ ++ +Q+ + + +++S
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
++L AST + + +KR + E++ + E D+LE K +NR L + +
Sbjct: 1377 KKKLQD----FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE--KTKNR-LQQEL 1429
Query: 435 MKLELGLHECSLPVSPLGSIATRF----LEEEELRSHHILERLDAHIEELKRESE 485
L + L VS L +F EE+ + S + ER A E ++E++
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Score = 60.1 bits (144), Expect = 5e-09
Identities = 86/358 (24%), Positives = 159/358 (44%), Gaps = 54/358 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1602 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1656
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1769
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1875
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE 351
+VK Q + ++A ++L +EL E E + M N K+++++ E
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 54.7 bits (130), Expect = 2e-07
Identities = 81/385 (21%), Positives = 170/385 (44%), Gaps = 40/385 (10%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 770 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 828
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 829 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 886
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---- 942
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
A + A + + LE ++L E+ ++++ +A+IKKL+++IL +
Sbjct: 943 AERKKMAQQMLDLE----------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 359 SYSSALEGMKM---EISHLTQEL---HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE 412
+ + K+ IS LT L ++ + K M L ++K E E
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 413 HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLG---SIATRFLEEEELRSHHI 469
+++ +LE + E + L+ + E + ++ A L++E + ++
Sbjct: 1053 LEKLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 470 LER---LDAHIEELKR--ESEKTVR 489
L++ L+ HI +L+ +SE+ R
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAAR 1134
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 96.7 bits (239), Expect = 4e-20
Identities = 102/491 (20%), Positives = 226/491 (46%), Gaps = 38/491 (7%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1151 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1210 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1262
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVE----HKEI 416
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ +E
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 417 LDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAH 476
L+ E L+ N+ L + L + V L + R LE + +E +
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK-SKRALETQ-------MEEMKTQ 1554
Query: 477 IEELKRESEKT 487
+EEL+ E + T
Sbjct: 1555 LEELEDELQAT 1565
Score = 85.9 bits (211), Expect = 8e-17
Identities = 98/500 (19%), Positives = 219/500 (43%), Gaps = 52/500 (10%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKI--REQELKSL----------- 64
L E + +L ++ +++ ++E E A E +++ ++QEL+ +
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 65 ---RSQLDVTHKEVGM----LHQQVEEHEKIKQEMTME---YKQELKKLHEELCILKRSY 114
QL K++ L +Q+EE E +Q++ +E + ++KKL +E+ ++
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR 174
KL K+ + E+R I LT + E +K+ + K + ++ +S LE +
Sbjct: 1002 NKLSKE---------RKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 175 KALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
K + E + +L K+KLE +I L +++ + E E++ R+
Sbjct: 1051 K----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 235 NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
+D + L++ ++ E + + L E L E+ A + + +L E K +L+
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Query: 295 EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 354
+ + +T TQ + A + V+ K L +E +++ M + + E+ + EQ
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 355 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-- 412
+ + + + ++ E + L EL + K +K+L A++Q+ + K +
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 413 --HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHIL 470
E+ D++ L+ E ++ M+ + E + + V+ S++++ + +EL
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA---SLSSQLQDTQELLQEETR 1336
Query: 471 ERLDAHIEELKRESEKTVRQ 490
++L+ + + E E+ Q
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQ 1356
Score = 82.8 bits (203), Expect = 7e-16
Identities = 97/421 (23%), Positives = 185/421 (43%), Gaps = 36/421 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1509 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1621
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1857
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEC 444
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 445 S 445
+
Sbjct: 1918 T 1918
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/432 (22%), Positives = 197/432 (45%), Gaps = 50/432 (11%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1028
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI 469
A +E+ +QLE K +L + LE + + G + R L + + H
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------GEL--RVLGQAKQEVEHK 1260
Query: 470 LERLDAHIEELK 481
++L+A ++EL+
Sbjct: 1261 KKKLEAQVQELQ 1272
Score = 70.9 bits (172), Expect = 3e-12
Identities = 97/502 (19%), Positives = 217/502 (43%), Gaps = 49/502 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1265 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1384 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEIKKLKEQ 352
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E++ ++Q
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 353 ---ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
++ L+ ++++ + + + + D ++ L ++
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPL-----GSIATRFLEEEEL 464
KE + +SL+ + L E + E + L L S++ R ++E
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 465 RSHHILERLDAHIEELKRESEK 486
R RL+A I +L+ E E+
Sbjct: 1739 R------RLEARIAQLEEELEE 1754
Score = 67.4 bits (163), Expect = 3e-11
Identities = 105/535 (19%), Positives = 223/535 (41%), Gaps = 94/535 (17%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ EA++++L +I +M + + + L K+ E+ + L + L ++ L
Sbjct: 982 TAEAKIKKLEDEILVM--------DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 80 QQVEEHEKIKQEMTMEYK------QELKKL-----------HEELCILK----------- 111
+ +HE + E+ + K QEL+KL HE++ L+
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 112 RSYEKLQK----------------KQMREFRGNTKNHRED------------------RS 137
+ E+LQ K++RE G+ + +ED
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E+E L ++E+ + ++ R +Q+V+ L +KAL E++ +AQ+ +QK
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQK--- 1207
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
+ E+ + +RA + N+ +E+ DL G + Q +Q+ E K ++
Sbjct: 1208 -HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA---DLAGELRVLGQAKQEVEHKKKK 1263
Query: 258 SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSAT 317
E ++ LQ + + + A + +H+ + + E + + + A + S+S+
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 318 CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI---LQGEQSYSSALEGMKMEISHL 374
+ + L E+ + + + + E L++Q+ ++ +Q+ + + +++S
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
++L AST + + +KR + E++ + E D+LE K +NR L + +
Sbjct: 1384 KKKLQD----FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE--KTKNR-LQQEL 1436
Query: 435 MKLELGLHECSLPVSPLGSIATRF----LEEEELRSHHILERLDAHIEELKRESE 485
L + L VS L +F EE+ + S + ER A E ++E++
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Score = 60.1 bits (144), Expect = 5e-09
Identities = 86/358 (24%), Positives = 159/358 (44%), Gaps = 54/358 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1609 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1663
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1776
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1882
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE 351
+VK Q + ++A ++L +EL E E + M N K+++++ E
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 54.7 bits (130), Expect = 2e-07
Identities = 81/385 (21%), Positives = 170/385 (44%), Gaps = 40/385 (10%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 777 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 835
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 836 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 893
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---- 949
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
A + A + + LE ++L E+ ++++ +A+IKKL+++IL +
Sbjct: 950 AERKKMAQQMLDLE----------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 359 SYSSALEGMKM---EISHLTQEL---HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE 412
+ + K+ IS LT L ++ + K M L ++K E E
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 413 HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLG---SIATRFLEEEELRSHHI 469
+++ +LE + E + L+ + E + ++ A L++E + ++
Sbjct: 1060 LEKLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 470 LER---LDAHIEELKR--ESEKTVR 489
L++ L+ HI +L+ +SE+ R
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAAR 1141
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 96.7 bits (239), Expect = 4e-20
Identities = 102/491 (20%), Positives = 226/491 (46%), Gaps = 38/491 (7%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1151 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1210 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1262
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVE----HKEI 416
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ +E
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 417 LDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAH 476
L+ E L+ N+ L + L + V L + R LE + +E +
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK-SKRALETQ-------MEEMKTQ 1554
Query: 477 IEELKRESEKT 487
+EEL+ E + T
Sbjct: 1555 LEELEDELQAT 1565
Score = 85.9 bits (211), Expect = 8e-17
Identities = 98/500 (19%), Positives = 219/500 (43%), Gaps = 52/500 (10%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKI--REQELKSL----------- 64
L E + +L ++ +++ ++E E A E +++ ++QEL+ +
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 65 ---RSQLDVTHKEVGM----LHQQVEEHEKIKQEMTME---YKQELKKLHEELCILKRSY 114
QL K++ L +Q+EE E +Q++ +E + ++KKL +E+ ++
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR 174
KL K+ + E+R I LT + E +K+ + K + ++ +S LE +
Sbjct: 1002 NKLSKE---------RKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 175 KALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
K + E + +L K+KLE +I L +++ + E E++ R+
Sbjct: 1051 K----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 235 NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
+D + L++ ++ E + + L E L E+ A + + +L E K +L+
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Query: 295 EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 354
+ + +T TQ + A + V+ K L +E +++ M + + E+ + EQ
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 355 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-- 412
+ + + + ++ E + L EL + K +K+L A++Q+ + K +
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 413 --HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHIL 470
E+ D++ L+ E ++ M+ + E + + V+ S++++ + +EL
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA---SLSSQLQDTQELLQEETR 1336
Query: 471 ERLDAHIEELKRESEKTVRQ 490
++L+ + + E E+ Q
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQ 1356
Score = 82.8 bits (203), Expect = 7e-16
Identities = 97/421 (23%), Positives = 185/421 (43%), Gaps = 36/421 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1509 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1621
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1857
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEC 444
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 445 S 445
+
Sbjct: 1918 T 1918
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/432 (22%), Positives = 197/432 (45%), Gaps = 50/432 (11%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1028
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI 469
A +E+ +QLE K +L + LE + + G + R L + + H
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------GEL--RVLGQAKQEVEHK 1260
Query: 470 LERLDAHIEELK 481
++L+A ++EL+
Sbjct: 1261 KKKLEAQVQELQ 1272
Score = 70.9 bits (172), Expect = 3e-12
Identities = 97/502 (19%), Positives = 217/502 (43%), Gaps = 49/502 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1265 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1384 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEIKKLKEQ 352
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E++ ++Q
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 353 ---ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
++ L+ ++++ + + + + D ++ L ++
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPL-----GSIATRFLEEEEL 464
KE + +SL+ + L E + E + L L S++ R ++E
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 465 RSHHILERLDAHIEELKRESEK 486
R RL+A I +L+ E E+
Sbjct: 1739 R------RLEARIAQLEEELEE 1754
Score = 67.4 bits (163), Expect = 3e-11
Identities = 105/535 (19%), Positives = 223/535 (41%), Gaps = 94/535 (17%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ EA++++L +I +M + + + L K+ E+ + L + L ++ L
Sbjct: 982 TAEAKIKKLEDEILVM--------DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 80 QQVEEHEKIKQEMTMEYK------QELKKL-----------HEELCILK----------- 111
+ +HE + E+ + K QEL+KL HE++ L+
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 112 RSYEKLQK----------------KQMREFRGNTKNHRED------------------RS 137
+ E+LQ K++RE G+ + +ED
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E+E L ++E+ + ++ R +Q+V+ L +KAL E++ +AQ+ +QK
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQK--- 1207
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
+ E+ + +RA + N+ +E+ DL G + Q +Q+ E K ++
Sbjct: 1208 -HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA---DLAGELRVLGQAKQEVEHKKKK 1263
Query: 258 SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSAT 317
E ++ LQ + + + A + +H+ + + E + + + A + S+S+
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 318 CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI---LQGEQSYSSALEGMKMEISHL 374
+ + L E+ + + + + E L++Q+ ++ +Q+ + + +++S
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
++L AST + + +KR + E++ + E D+LE K +NR L + +
Sbjct: 1384 KKKLQD----FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE--KTKNR-LQQEL 1436
Query: 435 MKLELGLHECSLPVSPLGSIATRF----LEEEELRSHHILERLDAHIEELKRESE 485
L + L VS L +F EE+ + S + ER A E ++E++
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Score = 58.9 bits (141), Expect = 1e-08
Identities = 85/354 (24%), Positives = 157/354 (44%), Gaps = 54/354 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1609 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1663
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1776
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1882
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIK 347
+VK Q + ++A ++L +EL E E + M N K++++
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 54.7 bits (130), Expect = 2e-07
Identities = 81/385 (21%), Positives = 170/385 (44%), Gaps = 40/385 (10%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 777 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 835
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 836 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 893
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---- 949
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
A + A + + LE ++L E+ ++++ +A+IKKL+++IL +
Sbjct: 950 AERKKMAQQMLDLE----------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 359 SYSSALEGMKM---EISHLTQEL---HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE 412
+ + K+ IS LT L ++ + K M L ++K E E
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 413 HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLG---SIATRFLEEEELRSHHI 469
+++ +LE + E + L+ + E + ++ A L++E + ++
Sbjct: 1060 LEKLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 470 LER---LDAHIEELKR--ESEKTVR 489
L++ L+ HI +L+ +SE+ R
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAAR 1141
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 96.7 bits (239), Expect = 4e-20
Identities = 102/491 (20%), Positives = 226/491 (46%), Gaps = 38/491 (7%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E ELQ + ++D +A K + + + LE + +++L S R+ + K+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L +++E K + E T++ +QEL+ K +E+ +LK++ ++ + + + + H
Sbjct: 1144 LGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ +E LT ++E+F++ + +K + +++ + L + + L + + ++ ++K+
Sbjct: 1203 Q---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE----HKKK 1255
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
KLE+ QS+ ND + + E+E +T +N+ G ++ + ++
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 254 KLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+L+++++LL+ +K R+L+ S ++ + E K+ L+ + N Q +
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKA---EIKKLKEQILQGEQSYSSA 363
L+ ++T + L + +E++ + E A +++K K ++ Q
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSS---DMEKRLRAEMQKAEDKAVE----HKEI 416
L+ + +S+L ++ + D +A K SS D R AE ++ E KA+ +E
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 417 LDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAH 476
L+ E L+ N+ L + L + V L + R LE + +E +
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK-SKRALETQ-------MEEMKTQ 1547
Query: 477 IEELKRESEKT 487
+EEL+ E + T
Sbjct: 1548 LEELEDELQAT 1558
Score = 85.9 bits (211), Expect = 8e-17
Identities = 98/500 (19%), Positives = 219/500 (43%), Gaps = 52/500 (10%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKI--REQELKSL----------- 64
L E + +L ++ +++ ++E E A E +++ ++QEL+ +
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 65 ---RSQLDVTHKEVGM----LHQQVEEHEKIKQEMTME---YKQELKKLHEELCILKRSY 114
QL K++ L +Q+EE E +Q++ +E + ++KKL +E+ ++
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR 174
KL K+ + E+R I LT + E +K+ + K + ++ +S LE +
Sbjct: 995 NKLSKE---------RKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 175 KALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
K + E + +L K+KLE +I L +++ + E E++ R+
Sbjct: 1044 K----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 235 NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
+D + L++ ++ E + + L E L E+ A + + +L E K +L+
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISD---LQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 295 EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 354
+ + +T TQ + A + V+ K L +E +++ M + + E+ + EQ
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 355 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-- 412
+ + + + ++ E + L EL + K +K+L A++Q+ + K +
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 413 --HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHIL 470
E+ D++ L+ E ++ M+ + E + + V+ S++++ + +EL
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA---SLSSQLQDTQELLQEETR 1329
Query: 471 ERLDAHIEELKRESEKTVRQ 490
++L+ + + E E+ Q
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQ 1349
Score = 82.8 bits (203), Expect = 7e-16
Identities = 97/421 (23%), Positives = 185/421 (43%), Gaps = 36/421 (8%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE K+ + E++ L S D +VG ++E+ ++ + E K +L++L +EL
Sbjct: 1502 LERTNKMLKAEMEDLVSSKD----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 110 -------LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
L+ + + L+ + R+ + + + E R +++R ++ E+ + D KQR +
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRAL 1614
Query: 163 YQQQVSSLEAQRKALAEQSEII---QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
LE K L Q++ + + + + +KL++ Q E++ + + T
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 220 ICANELEIERLTMRV----NDLVGTSMTVLQEQQQKEEKLRESEKLLE---ALQEEKREL 272
NE + + L + DL Q +KEE E L ALQ+EKR L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 273 KAALQSQENLIHEARIQKEKLQEKV-KAT------NTQHAVEAISLESVSATCKQLSQEL 325
+A + E + E + E + ++V KAT + + A E + + + +QL ++
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 326 MEKYEELKRME-AHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
E +L ME A +++K+ I L+ +I Q E+ +E E T+ L Q+D
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQEAREKQAATKSLKQKDKK 1850
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEC 444
+ D K ++AE K++ QLE + E++ ++ KL+ L E
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 445 S 445
+
Sbjct: 1911 T 1911
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/432 (22%), Positives = 197/432 (45%), Gaps = 50/432 (11%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ---MREFRGNTKNHREDRSEI 139
EE + K++ + K+ +K EL L++ + +L +++ + + T+ + E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR---KQKLE 196
RL AK +E + + E + + + L+A+RK +A+Q ++ QL +QKL+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIER--LTMRVNDLVGTSMTVLQEQQQKEEK 254
+++++++I+ L ++ +D N+L ER L R++DL T L E+ EEK
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQ--NNKLSKERKLLEERISDLT----TNLAEE---EEK 1021
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-------EKVKATNTQHAVE 307
+ KL + EL+ L+ +E E K KL+ E++ Q A
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 308 AISL----ESVSATCKQLSQELMEKYEELKR---MEAHNNEYKAEI---KKLKEQILQGE 357
+ L E + A +L E+ +K LK+ +E H ++ + ++ + + + + +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 358 QSYSSALEGMKMEI------SHLTQELH-QRDITIASTKGSSSDMEKRLRAEMQKAEDK- 409
+ LE +K E+ + QEL +R+ + K + + + A++Q+ K
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI 469
A +E+ +QLE K +L + LE + + G + R L + + H
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------GEL--RVLGQAKQEVEHK 1253
Query: 470 LERLDAHIEELK 481
++L+A ++EL+
Sbjct: 1254 KKKLEAQVQELQ 1265
Score = 70.9 bits (172), Expect = 3e-12
Identities = 97/502 (19%), Positives = 217/502 (43%), Gaps = 49/502 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA++QEL + ++E + H L+ ++ L + K+V L Q
Sbjct: 1258 EAQVQELQSKCSDG-ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 82 VEEHEKIKQEMT---MEYKQELKKLHEELCILKRSY-EKLQKKQMREFRGNTKNHREDRS 137
+++ +++ QE T + +L++L EE L+ E+++ KQ E +T N + S
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
+ K+++F E+ + +Q+++ +L Q + A + ++ +Q+L+
Sbjct: 1377 K-----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 198 --VELSSQSEIQHLSSKLERANDTICANELEIE----------RLTMRVNDLVGTSMT-V 244
V+L +Q ++ K +R D + A E I R + S+
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 245 LQEQQQKEEKLRESEKLLEALQEE-----------KRELKAALQSQENLIHEARIQKEKL 293
L+E + +E+L + K+L+A E+ EL+ + ++ E + E + Q E+L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEIKKLKEQ 352
+++++AT ++++++ ++ Q E+ EE +R ++ +EY+ E++ ++Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 353 ---ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
++ L+ ++++ + + + + D ++ L ++
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPL-----GSIATRFLEEEEL 464
KE + +SL+ + L E + E + L L S++ R ++E
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 465 RSHHILERLDAHIEELKRESEK 486
R RL+A I +L+ E E+
Sbjct: 1732 R------RLEARIAQLEEELEE 1747
Score = 67.4 bits (163), Expect = 3e-11
Identities = 105/535 (19%), Positives = 223/535 (41%), Gaps = 94/535 (17%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ EA++++L +I +M + + + L K+ E+ + L + L ++ L
Sbjct: 975 TAEAKIKKLEDEILVM--------DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 80 QQVEEHEKIKQEMTMEYK------QELKKL-----------HEELCILK----------- 111
+ +HE + E+ + K QEL+KL HE++ L+
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 112 RSYEKLQK----------------KQMREFRGNTKNHRED------------------RS 137
+ E+LQ K++RE G+ + +ED
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E+E L ++E+ + ++ R +Q+V+ L +KAL E++ +AQ+ +QK
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQK--- 1200
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
+ E+ + +RA + N+ +E+ DL G + Q +Q+ E K ++
Sbjct: 1201 -HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA---DLAGELRVLGQAKQEVEHKKKK 1256
Query: 258 SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSAT 317
E ++ LQ + + + A + +H+ + + E + + + A + S+S+
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 318 CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI---LQGEQSYSSALEGMKMEISHL 374
+ + L E+ + + + + E L++Q+ ++ +Q+ + + +++S
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
++L AST + + +KR + E++ + E D+LE K +NR L + +
Sbjct: 1377 KKKLQD----FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE--KTKNR-LQQEL 1429
Query: 435 MKLELGLHECSLPVSPLGSIATRF----LEEEELRSHHILERLDAHIEELKRESE 485
L + L VS L +F EE+ + S + ER A E ++E++
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Score = 58.9 bits (141), Expect = 1e-08
Identities = 85/354 (24%), Positives = 157/354 (44%), Gaps = 54/354 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALE----TCLKIREQELKSLRSQLDVTHKEVGM 77
E EL++ KQ + A KK + EG LE + +K RE+ +K LR +L K+
Sbjct: 1602 ETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD--- 1656
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK----------LHEELCILKRSYEK--LQKKQMREF 125
+++E+ + E+ K+ KK L E+L +R+ ++ L+K+++ E
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 126 RGNTKNHRED-RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
++ + R + E RL A+I + ++ L+ E Q + ++ + + +Q+E +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEE-LEEE------QGNMEAMSDRVRKATQQAEQL 1769
Query: 185 QAQLVNRK---QKLESVELSSQSEIQHLSSKLE--------RANDTICANELEIERLTMR 233
+L + QK ES + + + L SKL + TI A E +I +L +
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 234 VNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
V + +QK++KL+ E L + + E K A Q +E Q EK
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLK------EILLQVEDERKMAEQYKE--------QAEKG 1875
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIK 347
+VK Q + ++A ++L +EL E E + M N K++++
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 54.7 bits (130), Expect = 2e-07
Identities = 81/385 (21%), Positives = 170/385 (44%), Gaps = 40/385 (10%)
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY--QQQVSSLEAQRKALAEQSE 182
FR H E+ ++ ++T I F+ + ++ QQQ+++++ ++ A +
Sbjct: 770 FRTGVLAHLEEERDL-KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK 828
Query: 183 IIQAQ---LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ Q L + + L V + E+Q +L++ + E E++ L + + L
Sbjct: 829 LRNWQWWRLFTKVKPLLQVT-RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT- 886
Query: 240 TSMTVLQEQQQKEEKL-RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+LQEQ Q E +L E+E++ L +K+EL+ L E + E + ++LQ
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---- 942
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
A + A + + LE ++L E+ ++++ +A+IKKL+++IL +
Sbjct: 943 AERKKMAQQMLDLE----------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 359 SYSSALEGMKM---EISHLTQEL---HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE 412
+ + K+ IS LT L ++ + K M L ++K E E
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 413 HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLG---SIATRFLEEEELRSHHI 469
+++ +LE + E + L+ + E + ++ A L++E + ++
Sbjct: 1053 LEKLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 470 LER---LDAHIEELKR--ESEKTVR 489
L++ L+ HI +L+ +SE+ R
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAAR 1134
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 95.1 bits (235), Expect = 1e-19
Identities = 121/563 (21%), Positives = 247/563 (43%), Gaps = 100/563 (17%)
Query: 21 CEAELQELMKQIDIMV-AH--------------KKSEWEGRTHALETCLKIR---EQELK 62
CE E + L+K +I+ AH K++E E + L LK R E+EL
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 63 SLRSQLDVTHKEV-GMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK-- 119
L+ Q D +E+ + +Q H++ + E++ +++ + L E L K
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 120 -KQMREFRGNTKNHRED----RSEIERLTAKIEEFR---------------------QKS 153
K ++E + + +N D E+++ +AK++ F+ QK
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 154 LDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS--- 210
LD E +R++ +QV+ +EAQ+K + + + + Q+ + Q+LE + +++ L+
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 211 -SKLERANDTICANE---LEIERLTMRVNDLVGTSMTVLQEQ------------QQKEEK 254
SKLE N + +E E + +++ + + +L ++ ++ E K
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESV 314
+ EK +E ++++ +E++ L+ ++ L EA+++KE ++ + + A LE
Sbjct: 949 FKNQEKKMEKVKQKAKEMQETLK-KKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 315 SATCKQLSQ-----ELMEKYEELKRMEAHNNEYKAEI----KKLKEQILQGEQSYSSALE 365
A +S E +K + E H E I KKL +Q + ++ + L+
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQ 1067
Query: 366 GMKMEISHLTQEL---------HQRDITIASTKGSSSD-----MEKRLRAEMQKAEDKAV 411
+ E++ L Q++ ++IT +G D ++++L+ + A
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 412 EHKEILDQLESLKL-------ENRHLSEMVMKLELGLHECSLPVSPLGS-IATRFLEEEE 463
+ ++ LE L++ EN L E +++L++ E VS L S + T E +
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
Query: 464 LRSHHILERLDAHIEELKRESEK 486
L+S H E+ + +E+ E +K
Sbjct: 1188 LKSSH--EKSNKSLEDKSLEFKK 1208
Score = 83.2 bits (204), Expect = 5e-16
Identities = 108/544 (19%), Positives = 240/544 (44%), Gaps = 81/544 (14%)
Query: 5 LEGIQNR-GHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE----- 58
LE +Q R L C+ +Q +Q ++ + K++ E L+ KI++
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 59 -----QELKSLRSQLDVTHKEVGML----HQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
+L+ ++ ++ ++ GM+ +Q+ E ++K+E + + +K++ +
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI-EEFRQKSLDWEKQRLIYQQQVS 168
L+ EK ++ E ++ +L A++ E+ + E++R+ QQ++S
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 169 SL---------EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQH---------LS 210
+ ++ + +A+ ++ + +L ++Q+L + + E Q S
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR----ESEKLLE-AL 265
L+ + + L +E L ++ ++ S L++ QQ+ E R E E LE +L
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 266 QEEK---RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLS 322
QE K ++L L++++N H I + K + + +H +A+ E + +Q
Sbjct: 581 QENKNQSKDLAVHLEAEKNK-HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 323 QE---LMEKYEELKRMEAHNNE--YKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQE 377
E L EK E+ K + E ++A I+++ E+ L+ + LE + E+S + +
Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699
Query: 378 LHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL-----ESLKLENRHLSE 432
H+ + ++ K + M++ L A+M + ++ H++ +D + S++ + L +
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKN---HHQQQVDSIIKEHEVSIQRTEKALKD 756
Query: 433 MVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELK---RESEKTVR 489
+ +LEL L E ++ L+ H AH+E L+ + SE ++
Sbjct: 757 QINQLELLLKE----------------RDKHLKEH------QAHVENLEADIKRSEGELQ 794
Query: 490 QFTA 493
Q +A
Sbjct: 795 QASA 798
Score = 72.4 bits (176), Expect = 9e-13
Identities = 88/413 (21%), Positives = 182/413 (44%), Gaps = 47/413 (11%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSL----RSQLDVTHK 73
LT AE++ K + + K + + LE EQ++KSL S+L+ +K
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
Query: 74 EVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
E Q + E E + +M K+E++ L ++L + S L + E+ KN
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE----EYETKFKNQE 953
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL---AEQSEIIQAQLVN 190
+ ++++ +++E +K L ++ +L + + ++LE +K A+ E+ QA
Sbjct: 954 KKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 191 RKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQ 250
+ +E + + +I+ L+ E+ R +ND++ L +Q +
Sbjct: 1014 ISDAVSRLETNQKEQIESLT---------------EVHR--RELNDVISIWEKKLNQQAE 1056
Query: 251 KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIS 310
+ +++ E +Q +++E + A Q+ L+ +KE++ +++ + + +
Sbjct: 1057 ELQEIHE-------IQLQEKEQEVAELKQKILLFGC--EKEEMNKEITWLKEEGVKQDTT 1107
Query: 311 LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI-KKLKEQILQGEQ--SYSSALEGM 367
L + KQ S + ++ +++AH + + ++ K LKE EQ E
Sbjct: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167
Query: 368 KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
K ++S LT +L D S K S K L EDK++E K++ ++L
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL-------EDKSLEFKKLSEEL 1213
Score = 68.2 bits (165), Expect = 2e-11
Identities = 108/482 (22%), Positives = 211/482 (43%), Gaps = 94/482 (19%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHAL------ETCLKIREQELKSLRSQLDVT 71
L+ +LQE +++ I+ KS ++ L + EQE + + T
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 72 HKE-VGMLHQQVEEHEKIKQ--------------EMTMEYKQELKKL-------HEELCI 109
++E + +L + + E EK+ Q EM +Y++ L KL HE+ +
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSM 1793
Query: 110 LKRSYEKLQKKQMR---------EFRGNTKNHREDRSEIER-------------LTAKIE 147
+ E+L++K + E G KN+ + + +E LT +I
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGG-KNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852
Query: 148 EFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQA--QLVNRKQKLESVELSSQSE 205
E + K LD L+ Q++V +E + L + E +QA Q+ R + E +E +++ +
Sbjct: 1853 EQKIKELD---SCLVRQKEVHRVEMEE--LTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907
Query: 206 IQH-------LSSKLERANDT---ICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKL 255
+ LS+ + ND + E E ++L + L + +E QQ+ E L
Sbjct: 1908 SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL 1967
Query: 256 RES--EKLLEALQEEKRELKAALQSQ-ENLIHEARIQ----KEKLQEKVKAT-NTQHAVE 307
++ ++ E +++E+ +L+ S + L+ E Q +++L+ +K T N VE
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027
Query: 308 AISLESVSATCKQLSQELMEKYEELKR--------MEAHNNEYKAEIKKLKEQILQGEQS 359
A LES QL +++ EK ++LKR ++A E A+++ L+ Q+ + ++
Sbjct: 2028 AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087
Query: 360 YSSALE------GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH 413
Y LE + I L +L Q+ I+ +K E+ R ++ ED+ ++
Sbjct: 2088 YQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLK----EQEFREQIHNLEDRLKKY 2143
Query: 414 KE 415
++
Sbjct: 2144 EK 2145
Score = 67.4 bits (163), Expect = 3e-11
Identities = 110/587 (18%), Positives = 253/587 (43%), Gaps = 126/587 (21%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE---TCLKIREQELKSLRSQLDVTHKE 74
++ EA+L++L ++ + + ++ TH LE +K + +++SL ++ + KE
Sbjct: 1271 VSELEAQLRQLTEEQNTL----NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE 1326
Query: 75 VGMLHQQVEEHE----KIKQEMTMEY------KQELKKLHEELCILKRSYEKLQ------ 118
G Q E E ++K+E++ K+ELK+ E+ L + L
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386
Query: 119 ---KKQMREFRGNTKNHREDRSEI----------------ERLTA--KIEEFRQKSLDWE 157
++ K + E++ E+ E+++A +++++ K +W+
Sbjct: 1387 ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
Query: 158 KQ-------------RLIYQQQVSSLEAQRK---------ALAEQS---EIIQAQLVNRK 192
K+ L Q ++ S EA K L +Q+ + ++ ++ + K
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLT-----------MRVNDLVGTS 241
K+E E + ++E++ ++++ D I +EIE L + +LV
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ ++K+ +++E+E+ + L+ + +KA L++++ + + + +E++KA
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 302 TQHAVEAISL---------ESVSATCKQLSQELMEKYEELKR-MEAHNNEYKAEIKK--- 348
+ E+ + + ++A KQL ++ EK E+ K+ E+H +E ++++
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
Query: 349 ----LKEQILQGEQSYSSAL-------------EGMKMEISHLTQELHQRDITIASTKGS 391
L+E++ E S S L E + + Q+ ++ I++ + +
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV--LQRN 1744
Query: 392 SSDMEKRLRAEMQKAEDKAVEHKEILDQLES--LKLENRHLSE-----MVMKLELGLHEC 444
++ EK L+ Q+ E+ H E+ Q + +KLE+ + M+ L+ L E
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
Query: 445 SLPVSPLGSIATRFLEEE----ELRSHHILERLDAHIEELKRESEKT 487
+ S I + +E+E +++ LE + +++ +E E T
Sbjct: 1805 NKKYS---LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELT 1848
Score = 66.2 bits (160), Expect = 6e-11
Identities = 118/584 (20%), Positives = 246/584 (42%), Gaps = 133/584 (22%)
Query: 24 ELQELMKQIDIM---VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQ 80
EL + K+ D + + KS+ E + LET LK + + L + E+ L++
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546
Query: 81 QVEEHEKIK--------------QEMTMEYKQELKKLHEELCILKRSYEKL------QKK 120
++ + + K QE+ E +K+ E++ L+ + +KK
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 121 QMREFRGNTKNHREDRSEIE-----RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
++ + K+ E+ +E AK+ E ++K+ +K I +Q +S +E + +
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA--EQKIAAIKKQLLSQMEEKEE 1664
Query: 176 ALAEQSEIIQAQLVNR-----------KQKLESVELSSQSE--IQHLSSK-------LER 215
+ +E ++L + ++KL+SVE SSQSE I S+K E
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEE 1723
Query: 216 ANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE--------KLRESEKLL----- 262
A+ C + E++++ +L + + Q+KEE + + E+L+
Sbjct: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 263 EALQEEKRELKAALQSQ-------ENLIHEARIQKEKLQEKVKA-TNTQHAVEAI--SLE 312
EA Q E + + LQ + +LI ++KE + ++A N ++ + + +L+
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843
Query: 313 SVSATCKQLSQ---------------------ELMEKYEELKRME------------AHN 339
TC+ L Q EL KYE+L+ ++ N
Sbjct: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEEN 1903
Query: 340 NEYKAEIKKLKEQILQGEQSYSSALE----GMKMEISHLTQEL-------------HQRD 382
E K++ ++ ++L ++ + LE G + E L +E+ HQ++
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE 1963
Query: 383 ITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLH 442
+ I K + E++++ Q+ ED ++H L QL ++ N L++ +LE+ +
Sbjct: 1964 LEILK-KEYDQEREEKIK---QEQEDLELKHNSTLKQL--MREFNTQLAQKEQELEMTIK 2017
Query: 443 ECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 486
E ++ + LE + ++ +L+++ ++LKR +++
Sbjct: 2018 E---TINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/478 (21%), Positives = 197/478 (41%), Gaps = 88/478 (18%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E +EL I I + E E L+ +EQE+ L+ ++ + E ++++
Sbjct: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 82 VE--EHEKIKQEMTM-EYKQELKK-------LHEELCILKRSYEKLQKKQMREFRGNTKN 131
+ + E +KQ+ T+ E +++LK+ L ++ LK EKL+ + + NT
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 132 HR----------EDRSEIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL 177
ED+ ++ LT+K+ EEF+ EK + + + + L
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 178 AEQSEI--------IQA---QLVNRKQKLESVELSSQSEIQHLSSKLERA----NDTICA 222
A Q +I ++A +L+N + LS S QH ++K++ A T+
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 223 NELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENL 282
E ++ +LT N L + + ++KE +++ + +E+L EK ALQ +
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGGN 1329
Query: 283 IHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEY 342
+A +KE + QL +EL E + M+ E
Sbjct: 1330 QQQAASEKE------------------------SCITQLKKELSENINAVTLMKEELKEK 1365
Query: 343 KAEIKKLKEQI------LQGEQSYS---SALEGM-------KMEISHLTQELHQRDITIA 386
K EI L +Q+ LQ S S +A+ + K E+ Q+L + T++
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425
Query: 387 STKGSS----SDMEKRLRAEMQKAEDKAVEHKEILDQLE-SLKLENRHLSEMVMKLEL 439
K S+ D + +KA+ + +H+ + +L+ L+L+++ E ++ L
Sbjct: 1426 KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Score = 57.8 bits (138), Expect = 2e-08
Identities = 87/471 (18%), Positives = 186/471 (39%), Gaps = 38/471 (8%)
Query: 30 KQIDIMVAHKKSEWEGRTHAL--ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEK 87
K+I+I+ K S E H L E K + QE K + + + + + +++ K
Sbjct: 922 KEIEILT-QKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 88 IKQEM---TMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTA 144
+K+E+ +E Q+ K+ + ++ + ++ + N K E +E+ R
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--- 1037
Query: 145 KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQS 204
E WEK+ QQ L+ + ++ E A+L + +
Sbjct: 1038 --RELNDVISIWEKK---LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNK 1092
Query: 205 EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEA 264
EI L + + + T+ + ++++ + VN L + ++ E L +S K
Sbjct: 1093 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1152
Query: 265 LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQE 324
LQE+ ELK + + + E + + E+ ++ + H SLE S K+LS+E
Sbjct: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
Query: 325 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
L +++ + +A ++ +++ S ++A+ H T ++ + +
Sbjct: 1213 L------AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEC 444
T S++E +LR ++ + ++ QLE + + M +E + E
Sbjct: 1267 KTCT---VSELEAQLRQLTEEQNTLNISFQQATHQLEE---KENQIKSMKADIESLVTE- 1319
Query: 445 SLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 495
L++E ++ I +LK+E + + T +K
Sbjct: 1320 -----------KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMK 1359
Score = 56.2 bits (134), Expect = 7e-08
Identities = 95/468 (20%), Positives = 202/468 (43%), Gaps = 78/468 (16%)
Query: 41 SEWEGRTHALETCLKIREQELKSLRSQL----DVTHKEVGMLHQQVEEHEKIKQEMTMEY 96
S + G+ L T ++ ++E K L+ L D + + + L ++++ ++ K+ + E+
Sbjct: 151 SSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEF 210
Query: 97 KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW 156
L++ + + +L+ L K+++R N + + + +L + E F ++
Sbjct: 211 DASLEEKDQYISVLQTQVSLL-KQRLR----NGPMNVDVLKPLPQLEPQAEVFTKEE--- 262
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
+ E+ + + E ++ LE++ Q ++ + L+R
Sbjct: 263 ------------NPESDGEPVVEDGTSVKT--------LETL----QQRVKRQENLLKRC 298
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL 276
+TI +++ + LT L Q+Q +E+L+E EK+ + EK +L L
Sbjct: 299 KETIQSHKEQCTLLTSEKEAL----------QEQLDERLQELEKIKDLHMAEKTKLITQL 348
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVS---ATCKQLS---QELMEK-- 328
+ +NLI + ++++K + H + E ++ + KQ++ +EL E+
Sbjct: 349 RDAKNLIEQ--LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE 406
Query: 329 ------YEELKRMEAHNNEYKAEIKKLK----EQILQGEQSYSSALEGMKMEISHLTQEL 378
+EEL++ + + + +KLK EQI E++ ++ E+S + QE+
Sbjct: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
Query: 379 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSE-MVMKL 437
+ K SS + A++QK +K + KE + + L+ R E M + L
Sbjct: 467 ------VDVMKKSSEEQ----IAKLQKLHEKELARKE-QELTKKLQTREREFQEQMKVAL 515
Query: 438 ELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESE 485
E E + LEE EL+ IL + + +L++E+E
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE 563
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 95.1 bits (235), Expect = 1e-19
Identities = 119/532 (22%), Positives = 236/532 (44%), Gaps = 87/532 (16%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWE----------GRTHALETCLKIREQELKSLRSQ 67
L EAE +L + +AH+ S+++ + LE+ + + +L +L Q
Sbjct: 650 LIQIEAENSDLK----VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQ 705
Query: 68 LD---VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE 124
L+ V + + + ++E+ K E + + HE++C+ ++EK +K + +
Sbjct: 706 LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL---AFEKAKKIHLEQ 762
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQV----SSLEAQRKALAEQ 180
H+E +IERL A++E+ Q+ + EK + QQ + LE+ + L E
Sbjct: 763 -------HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTES 815
Query: 181 SEIIQAQLVNRKQKLESVELSSQSE---IQHLSSKLERANDTICANELEIERLTMRVNDL 237
++ + + + + L++++ E ++ L S LE IC E L + +N L
Sbjct: 816 KGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE-----ICK-----EELVLHLNQL 865
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLE----ALQEEKRE---LKAALQSQENLIHEARIQK 290
G ++ ++K E++ +K L+ +LQE + L+ LQ Q+ ++ + I+
Sbjct: 866 EGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYK----AEI 346
+L++ T T+ + LE ++ S E + K EE AH + K E+
Sbjct: 926 GELED----TQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIEL 981
Query: 347 KKLKEQILQGEQSYSSALEGMKMEISHLTQE-------LHQRDITIASTKGSSSDMEKRL 399
Q+ Y L M+ EI HL ++ L Q D+ + TK +++EK+
Sbjct: 982 TGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK---TELEKKT 1038
Query: 400 RA--EMQKAE-------DKAVEHKEILD--------QLESLKLENRHLSEMVMKLELGLH 442
A E++K + +A++ +E+L+ +L+S + + L +++ K +L L
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 443 ECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 494
E + L + E E + +LE +D ++E E ++ Q T L
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLE-MDQALKERNWELKQRAAQVTHL 1149
Score = 83.2 bits (204), Expect = 5e-16
Identities = 101/466 (21%), Positives = 197/466 (42%), Gaps = 70/466 (15%)
Query: 42 EWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK 101
E E + LE L+ ++Q+ K + + +++ +E +++ E E K+E
Sbjct: 765 EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENM 824
Query: 102 KLHEELCILKR--SYEKLQKKQM---------------REFRGNT----KNHREDRSEIE 140
K E L L+ S E ++ +Q+ + GN K ++ E+
Sbjct: 825 KKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884
Query: 141 RLTAKIEEFRQKSLDWEKQRLIYQ------QQVSSLEAQRKALAEQSEI-IQAQLVNRKQ 193
L +++ + +Q +I Q QQ+ E R E ++ ++ Q+ +Q
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 944
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
+L+ SS +++ + K E A A+E +++R +V +L GT+ V E Q +E
Sbjct: 945 ELQKQRESSAEKLRKMEEKCESA-----AHEADLKR--QKVIELTGTARQVKIEMDQYKE 997
Query: 254 KLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT-QHAVEAISLE 312
+L + EK + L+ + L + ++ + + + EK VK QH+ E E
Sbjct: 998 ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTE 1057
Query: 313 SVS-----------------ATCKQLSQ----------ELMEKYEELKRMEAHNNEYKAE 345
++ +T +QL + L EKY +K + A E K E
Sbjct: 1058 ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKME 1117
Query: 346 IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 405
I+ K+++L+ +Q AL+ E+ ++ D+TI +G +L ++K
Sbjct: 1118 IEDKKQELLEMDQ----ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEK 1173
Query: 406 AEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPL 451
+E +E KE Q+ESL + ++ E + + E + + +S L
Sbjct: 1174 SE---LELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQL 1216
Score = 78.2 bits (191), Expect = 2e-14
Identities = 93/464 (20%), Positives = 200/464 (43%), Gaps = 55/464 (11%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
EL++ +++ V+ + E + + + L+ E++ +S + D+ ++V L
Sbjct: 927 ELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTAR 986
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEK--LQKKQMREFRGNTKNHREDRSEIER 141
+ +K EM +YK+EL K+ +E+ LKR E + Q+ TK +E+E+
Sbjct: 987 Q---VKIEMD-QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK------TELEK 1036
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
T ++E ++L + + EA +K E+++ +L N +L+S
Sbjct: 1037 KTNAVKEL---------EKLQHSTETELTEALQKR-----EVLETELQNAHGELKS---- 1078
Query: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261
+ ++Q L L++A +L +E + DL E + K+++L E +
Sbjct: 1079 TLRQLQELRDVLQKA-------QLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMD-- 1129
Query: 262 LEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQL 321
+AL+E ELK +L R + ++++K+ + L+ + + L
Sbjct: 1130 -QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESL 1188
Query: 322 SQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR 381
+ +L E+L+ E + + EI +LK++I E + + + + ++
Sbjct: 1189 NDKLQNAKEQLREKEFIMLQNEQEISQLKKEI-----------ERTQQRMKEMESVMKEQ 1237
Query: 382 DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL 441
+ IA+ + D+ + LR ++ ++ H E+ + R + + +LE +
Sbjct: 1238 EQYIATQYKEAIDLGQELRLTREQVQN---SHTELAEARHQQVQAQREIERLSSELE-DM 1293
Query: 442 HECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESE 485
+ S G+ L ++R H+ R+ A I++L E E
Sbjct: 1294 KQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE 1337
Score = 71.2 bits (173), Expect = 2e-12
Identities = 97/434 (22%), Positives = 205/434 (47%), Gaps = 37/434 (8%)
Query: 18 LTSCEAELQ-ELMKQIDIMVA--HKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKE 74
LT + E++ E MK+ + + A ++ SE + L++ L+I ++EL +QL+ ++
Sbjct: 812 LTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEK 871
Query: 75 VG-MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
L ++ EE +++E+ ++ L++ E+ IL+ + ++ Q+ +E N +
Sbjct: 872 FEKQLKKKSEEVYCLQKELKIK-NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELE- 929
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+ ++++E+ +K+E+ QK + ++L ++ A L Q ++I+ R+
Sbjct: 930 DTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQ-KVIELTGTARQV 988
Query: 194 KLE----SVELSS-QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K+E ELS + EI HL K + N + ++L++ + D T +
Sbjct: 989 KIEMDQYKEELSKMEKEIMHL--KRDGENKAMHLSQLDM------ILDQTKTELEKKTNA 1040
Query: 249 QQKEEKLRESEK--LLEALQEEKRE-LKAALQSQENLIHEARIQKEKLQEKVKATNTQHA 305
++ EKL+ S + L EALQ KRE L+ LQ+ + Q ++L++ ++
Sbjct: 1041 VKELEKLQHSTETELTEALQ--KREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 306 VEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALE 365
+ +++ ++A ++ E+ +K +EL M+ E E+K+ Q+
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTH---------- 1148
Query: 366 GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKL 425
+ M I E+ Q+ I + T S K +++ DK KE L + E + L
Sbjct: 1149 -LDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIML 1207
Query: 426 EN-RHLSEMVMKLE 438
+N + +S++ ++E
Sbjct: 1208 QNEQEISQLKKEIE 1221
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/501 (20%), Positives = 216/501 (43%), Gaps = 63/501 (12%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
EL + +Q VA K + + LE L E+E K L+ + + E+ +L
Sbjct: 365 ELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILK---- 420
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCIL--KRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
EK++Q K+E E+L I+ K S Q + R+ ++ E++ EI R
Sbjct: 421 --EKLRQ-----LKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILR 473
Query: 142 ----LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
L + E + + ++ + QQ++ S + ++L E I +QL +++
Sbjct: 474 DKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL----EKIISQLPLKRELFGF 529
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRV----------------NDLVGTS 241
S+ ++ S+K +R AN+L I L +++ N L +
Sbjct: 530 KSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSL 589
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK-----EKLQEK 296
+T Q+ + E+E + + +K Q N +E Q+ E+L+ K
Sbjct: 590 ITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTK 649
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
+ +++ +++ ++ + + +EL+EK ++E+ + +++ L++Q+ +
Sbjct: 650 LIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEK 709
Query: 357 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-HKE 415
+YSS + + + L QEL +++ I S + + + +++ +KA+ +E HKE
Sbjct: 710 IVAYSS----IAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKE 765
Query: 416 ILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDA 475
+ Q+E L+ + + + E + L+++ + H LE LD
Sbjct: 766 MEKQIERLEAQLEKKDQQFKEQEKTM---------------SMLQQDIICKQHHLESLDR 810
Query: 476 HIEELKRESEK-TVRQFTALK 495
+ E K E +K +++ ALK
Sbjct: 811 LLTESKGEMKKENMKKDEALK 831
Score = 62.4 bits (150), Expect = 9e-10
Identities = 88/404 (21%), Positives = 172/404 (42%), Gaps = 46/404 (11%)
Query: 54 LKIREQELKSLRSQLD-VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK-KLHEELCILK 111
LKI E L+SL +L V+ E EK+ ++ + L +E +C +
Sbjct: 147 LKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKIS 206
Query: 112 RSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE 171
S QKK + ++ + EI+ L K+ + RQ++ + L
Sbjct: 207 GSSTDFQKKPRDKMFSSSAPVDQ---EIKSLREKLNKLRQQN--------------ACLV 249
Query: 172 AQRKALAEQSEIIQAQLVNRKQKLESVELSSQ--SEIQHLSSKLERANDTICANELEIER 229
Q +L + E I +L + K+ +E + Q + + L ++ + A + +
Sbjct: 250 TQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLRE 309
Query: 230 LTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL-LEALQEEKRELKAALQSQENLIHEARI 288
N L + V++++Q +E E KL ++ L++ K+ +A Q E L + +
Sbjct: 310 AE---NKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
Query: 289 QKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKK 348
K Q K K A LE V A + L + L +E KR++ YK+E++
Sbjct: 367 SKAFQQYKKKV--------AEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEI 418
Query: 349 LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKR---------L 399
LKE++ Q ++ ++ E +++ ++ + Q + S S++E + L
Sbjct: 419 LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL 478
Query: 400 RAEMQKAEDKAVEHKEILD----QLESLKLENRHLSEMVMKLEL 439
E ++ + + E LD ++ES ++E R L +++ +L L
Sbjct: 479 MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPL 522
Score = 35.4 bits (80), Expect = 0.12
Identities = 55/292 (18%), Positives = 117/292 (40%), Gaps = 28/292 (9%)
Query: 180 QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV----- 234
+ E + A + + + +L+ E S QS + LSS N N E+L + V
Sbjct: 132 EEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHP 191
Query: 235 --------NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
++ S + Q++ +K+ S ++ + RE L+ Q +
Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQ 251
Query: 287 RIQKEKLQEKVKATNTQHAVEAISLESV---SATCKQLSQELMEKYEELKRMEAHNNEYK 343
E + TQ + LES +A+ L ++++ E+ + E +
Sbjct: 252 NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAE 311
Query: 344 AEIKKLKEQILQGEQS-YSSALEGMKMEISHLTQEL------HQRDITIASTKGSSSDME 396
++++ ++ +++ EQS S E +K+++ L Q QR+ + + + S +
Sbjct: 312 NKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQ 371
Query: 397 KRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPV 448
+ + +K E E + + L + + EN+ L E GL++ L +
Sbjct: 372 QYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE-----RCGLYKSELEI 418
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 94.7 bits (234), Expect = 2e-19
Identities = 114/494 (23%), Positives = 218/494 (44%), Gaps = 78/494 (15%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
+Q +K R ++ +E+ H + E Q+ E + EL+K EEL +K E+
Sbjct: 637 QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQH 696
Query: 118 QKKQMREFRGNTKNHRED-----RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA 172
Q ++R+ + ++ RSE A IEE Q D + + ++Q L
Sbjct: 697 QT-EIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755
Query: 173 QRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTM 232
+ + L ++ ++ + Q+++ ++ +E+Q L +E A + E+ R
Sbjct: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV---EVLASRSNT 812
Query: 233 RVNDLVGTSMTV--LQEQQQK--------EEKLRESEKLLEALQEEKRELKAAL------ 276
D GT M V LQE+ +K E ++ + ++ +E L+ ++ + K L
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 277 --QSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR 334
Q +E L+H + +KE + + N A + +L + KQLS++L E+ E+ ++
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQG-NLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 335 MEAHNNEYKAE-------IKKLKEQILQ-GEQSYSSALE-----------------GMKM 369
+ NE + E I+KL++++ E S +S LE M+
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 370 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ-LESLKLE-- 426
++ T E + +T + ME+ LR + Q+A+D+A+ +++L+Q L+ L+ E
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELR-DYQRAQDEALTKRQLLEQTLKDLEYELE 1050
Query: 427 -NRHL----SEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLD---AHIE 478
HL S +V ++E + + + LEEE S + ER+ +E
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQLEME-----------LEEERNNSDLLSERISRSREQME 1099
Query: 479 ELKRE--SEKTVRQ 490
+L+ E E+ RQ
Sbjct: 1100 QLRNELLQERAARQ 1113
Score = 71.6 bits (174), Expect = 2e-12
Identities = 95/418 (22%), Positives = 192/418 (45%), Gaps = 37/418 (8%)
Query: 99 ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
E+K L E+ L +LQ++ E + N +N +E+R ER+ A +EE R + + +
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVK-NQQNIKEER---ERMRANLEELRSQHNEKVE 663
Query: 159 QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQ-SEIQHLSSKLERAN 217
+ QQ++ E + + E E+ Q ++ + + E +L Q SE+ +R+
Sbjct: 664 ENSTLQQRLEESEGELRKNLE--ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEE-KRELKAAL 276
D IE L DL +L ++++E+ LR+ E+ L AL+ K E+ +
Sbjct: 722 DR--EKGALIEELLQAKQDL----QDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHD 775
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEK--YEELKR 334
Q + L + + + L+E V+ VE ++ S ++ Q E+ K EE ++
Sbjct: 776 QEMDKLKEQYDAELQALRESVEEATKN--VEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
Query: 335 MEAHNNEYKAEIKKLKEQI--LQGEQSYS-SALEGMKMEISHLTQEL----HQRDITIAS 387
++ + E + + +L+ QI L+G+++ + L+ + EI L + L + +++
Sbjct: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
Query: 388 TKGSSSDME------KRLRAEMQKAEDKAVEHKEILDQLESLK--LENR--HLSEMVMKL 437
+ +++E + E ++ +K E E +QL LK +EN HL + + KL
Sbjct: 894 RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL 953
Query: 438 ELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 495
+ + + L+E + ++ L + ++E E+EK+ + TA+K
Sbjct: 954 QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS--RLTAMK 1009
Score = 65.5 bits (158), Expect = 1e-10
Identities = 97/440 (22%), Positives = 189/440 (42%), Gaps = 66/440 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E EL++ ++++ V ++ + + L+ L EL S + D +E G
Sbjct: 672 LEESEGELRKNLEEL-FQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED---REKGA 727
Query: 78 LHQQV--------------EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMR 123
L +++ EE E + ++ E L EE+ + +KL+++
Sbjct: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
Query: 124 EFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEI 183
E + R +E T +E +S E+ + + +V L+ + + L +SE
Sbjct: 788 ELQAL-------RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE 840
Query: 184 IQ---AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTIC-ANELEIERLTMR---VND 236
++ AQL + + L+ E ++ ++ ++ + + + A + E E ++ R N+
Sbjct: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
Query: 237 L---VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL 293
L G QEQ+Q EKL+E E+K +L+ EN EKL
Sbjct: 901 LEAAQGNLSQTTQEQKQLSEKLKEE-------SEQKEQLRRLKNEMENERWHLGKTIEKL 953
Query: 294 QEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI 353
Q+ E + S T Q +++Y+E R E + ++LKE+
Sbjct: 954 QK-----------EMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ-----RQLKEKT 997
Query: 354 LQGEQSYSSALEGMKMEISHLTQEL--HQRDITIASTK-----GSSSDMEKRLRAEMQKA 406
L+ E+S +A++ M+ E+ + +EL +QR A TK + D+E L A+
Sbjct: 998 LEAEKSRLTAMK-MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLK 1056
Query: 407 EDKAVEHKEILDQLESLKLE 426
+D++ K++ D++ L++E
Sbjct: 1057 DDRSRLVKQMEDKVSQLEME 1076
Score = 62.0 bits (149), Expect = 1e-09
Identities = 93/410 (22%), Positives = 177/410 (43%), Gaps = 76/410 (18%)
Query: 22 EAELQELMKQIDIMVAHKKS------EWEGRTHALETCLKIREQELKSLRSQLDVTHKEV 75
E + +L +QI+ + + ++EG LE L +E K S E+
Sbjct: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
Query: 76 ----GMLHQQVEEH----EKIKQEMTMEYKQELKKLHEEL----CILKRSYEKLQKKQ-- 121
G L Q +E EK+K+E E K++L++L E+ L ++ EKLQK+
Sbjct: 902 EAAQGNLSQTTQEQKQLSEKLKEES--EQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
Query: 122 -MREFRGNT---KNHREDRSEIER--LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
+ R +T +N ++ E R L + ++K+L+ EK RL + + +
Sbjct: 960 IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019
Query: 176 AL-----AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKL-ERANDTICANELEIER 229
L A+ + + QL+ + K EL ++S ++ S+L ++ D + E+E+E
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079
Query: 230 -------LTMRV-----------NDLVGTSMT--------VLQEQQQKEEKLR------- 256
L+ R+ N+L+ + E+Q K+ K R
Sbjct: 1080 ERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS 1139
Query: 257 ---ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISL-- 311
E L+ ++ EL+ L+S+E ++ +L+ KVK Q E +SL
Sbjct: 1140 YRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
Query: 312 --ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE--QILQGE 357
+ +S K + +++ E EE+ R+E+ + + E+++ + + LQG+
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ 1249
Score = 54.3 bits (129), Expect = 2e-07
Identities = 60/302 (19%), Positives = 139/302 (46%), Gaps = 20/302 (6%)
Query: 150 RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL--ESVELSSQSEIQ 207
R+ +L +EK + + + S + +A SE+ L+ +K KL E EL Q +++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV--KDLLEQKSKLTIEVAELQRQLQLE 633
Query: 208 HLSSK-LERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ 266
+ + ++ + + AN +E L + N+ V + T+ Q ++ E +LR++ + L ++
Sbjct: 634 VKNQQNIKEERERMRAN---LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 267 EEKRELKAA---LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQ 323
E+ + + LQ Q + +H+ ++ +++ K + ++A K+ +
Sbjct: 691 MEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQE 750
Query: 324 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQE---LHQ 380
+L+ K E + + A K E+ +++ + ++ Y + L+ ++ + T+ L
Sbjct: 751 DLLRKRE--RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLAS 808
Query: 381 RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHK----EILDQLESLKLENRHLSEMVMK 436
R T + + K L+ E +K + ++ E + ++ Q+E LK + E + K
Sbjct: 809 RSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKK 868
Query: 437 LE 438
E
Sbjct: 869 YE 870
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 91.3 bits (225), Expect = 2e-18
Identities = 120/454 (26%), Positives = 201/454 (44%), Gaps = 86/454 (18%)
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK-----LHEELCILKRSYEKLQKK--QMREFRGNTK 130
L++ EEH K QE +E + +L+K L ++ C+ +++ E LQ K Q+ E +
Sbjct: 341 LNELTEEHSKATQEW-LEKQAQLEKELSAALQDKKCLEEKN-EILQGKLSQLEEHLSQLQ 398
Query: 131 -NHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR-----KALAEQSEII 184
N +++ E+ ++E +Q++ Q +V LE +R K LAE+
Sbjct: 399 DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 185 QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTV 244
+ KQ+L S+ QS I +LS E A++ RLT +V L T+
Sbjct: 459 E-----EKQQLSSLITDLQSSISNLSQAKEELEQ---ASQAHGARLTAQVASLTSELTTL 510
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ---------- 294
QQ++++L L + +E++ +L LQ QE R Q E+L
Sbjct: 511 NATIQQQDQELAG---LKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567
Query: 295 ----EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
EK +AT HA + ++ ++ L E+ LK++EA E A+++ L+
Sbjct: 568 KEVAEKQEATRQDHA------QQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQ 621
Query: 351 EQILQGEQSYSSALEGM------KMEISHLTQELHQRDITIA-----STKGSSSDMEKRL 399
+Q+ ++ SA + K E+S +EL Q + A + +++E +L
Sbjct: 622 QQLQVANEARDSAQTSVTQAQREKAELSRKVEEL-QACVETARQEQHEAQAQVAELELQL 680
Query: 400 RAEMQKAEDK---AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIAT 456
R+E QKA +K A E ++ +QL++LK SL V+ GS
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKE-------------------SLKVTK-GS--- 717
Query: 457 RFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
LEEE+ R+ LE I ELK E+ V Q
Sbjct: 718 --LEEEKRRAADALEEQQRCISELKAETRSLVEQ 749
Score = 81.3 bits (199), Expect = 2e-15
Identities = 93/435 (21%), Positives = 188/435 (43%), Gaps = 52/435 (11%)
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK--QMREFRGNTK-NHREDR 136
+++EE + +TM + LK+ + LK ++ +K Q+ E G+ RE
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQD----LKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 137 SEIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
S +++L + EE + + +W +++ ++++S+ +K L E++EI+Q +L +
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+ L ++ + E K E D + L+ E T+ N+ T + E + E
Sbjct: 392 EHLSQLQDNPPQE------KGEVLGDVLQLETLKQEAATLAANN---TQLQARVEMLETE 442
Query: 253 EKLRESEKLLEA--LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIS 310
+E++ L E +EEK++L + + ++ I KE+L++ +A + + S
Sbjct: 443 RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
Query: 311 LES----VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEG 366
L S ++AT +Q QEL ++ K +A Q+ Q Q A +G
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQA--------------QLAQTLQQQEQASQG 548
Query: 367 MKMEISHLTQELHQRDITIAST----KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 422
++ ++ L+ L Q++ + + + D ++L ++ E E L QLE+
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA 608
Query: 423 LKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRF--LEEEELRSHHILERLDAHIEEL 480
L+ E KLE+ + + S T + E+ +E L A +E
Sbjct: 609 LE------KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETA 662
Query: 481 KRESEKTVRQFTALK 495
++E + Q L+
Sbjct: 663 RQEQHEAQAQVAELE 677
Score = 80.1 bits (196), Expect = 4e-15
Identities = 99/443 (22%), Positives = 205/443 (46%), Gaps = 47/443 (10%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
LTS L ++Q D +A K + + + L L+ +EQ + LR Q++ +
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 78 LHQQVEEHEKIKQEMTMEYKQEL--------KKLHEELCILKR----SYEKLQKKQMREF 125
QQ++E + ++ ++ Q+L L E LK+ EK K ++ +
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQV---SSLEAQRKALAEQSE 182
+ N D ++ T+ + R+K+ E R + + Q ++ + Q +A A+ +E
Sbjct: 623 QLQVANEARDSAQ----TSVTQAQREKA---ELSRKVEELQACVETARQEQHEAQAQVAE 675
Query: 183 IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM 242
++ QL + +QK E +Q + Q L +L+ +++ + +E R D
Sbjct: 676 -LELQLRSEQQKATEKERVAQEKDQ-LQEQLQALKESLKVTKGSLEEEKRRAAD------ 727
Query: 243 TVLQEQQQKEEKLR-ESEKLLEALQEEKRELKAALQSQENLIHEARIQK--EKLQEKVKA 299
L+EQQ+ +L+ E+ L+E + E++EL+ ++ L EAR+Q+ E Q + +
Sbjct: 728 -ALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL--EARLQQLGEAHQAETEV 784
Query: 300 TNTQHAVEAISLESVSATCKQLSQEL---MEKYEELKRMEA-HNNEYKAEIKKLKEQILQ 355
+ A + + + C+QL +E+ E+YE+ ++ EA + ++ ++ LKE+ +
Sbjct: 785 LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844
Query: 356 GEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE 415
Q A E + SH ++ I+ + +++ L +Q+ ++K V ++
Sbjct: 845 ARQELQEAKEKVAGIESH-------SELQISRQQNELAELHANLARALQQVQEKEVRAQK 897
Query: 416 ILDQLESLKLENRHLSEMVMKLE 438
+ D L +L+ + S+ V +LE
Sbjct: 898 LADDLSTLQEKMAATSKEVARLE 920
Score = 69.3 bits (168), Expect = 8e-12
Identities = 105/495 (21%), Positives = 194/495 (39%), Gaps = 51/495 (10%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
++L+E + Q+ +K E G LET +QE +L + V ML +
Sbjct: 388 SQLEEHLSQLQDNPPQEKGEVLGDVLQLETL----KQEAATLAANNTQLQARVEMLETER 443
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIE-- 140
+ E +++E ++L + L+ S L + K E S+
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ---------AKEELEQASQAHGA 494
Query: 141 RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVEL 200
RLTA++ SL E L + + + L +Q++ QAQL Q+ E
Sbjct: 495 RLTAQVA-----SLTSELTTL--NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
Query: 201 SSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE- 259
+ +++ LSS L++ + E+ ++ R + + + +++E LRE +
Sbjct: 548 GLRHQVEQLSSSLKQKEQQL--KEVAEKQEATRQDH----AQQLATAAEEREASLRERDA 601
Query: 260 --KLLEALQEEKRELKAALQSQENLIHEAR---------IQKEKLQEKVKATNTQHAVEA 308
K LEAL++EK LQ Q + +EAR Q+EK + K Q VE
Sbjct: 602 ALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVET 661
Query: 309 ISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 368
E A + EL + E+ K E E +L+EQ+ ++S ++
Sbjct: 662 ARQEQHEAQAQVAELELQLRSEQQKATE--KERVAQEKDQLQEQLQALKESLKVTKGSLE 719
Query: 369 MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESL----- 423
E L ++ I+ K + + ++ + E ++ E++ K + +L+ L
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQ 779
Query: 424 ---KLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 480
++ R L+E + EC V + + R+ E+ + + L
Sbjct: 780 AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY-EDSQQEEAQYGAMFQEQLMTL 838
Query: 481 KRESEKTVRQFTALK 495
K E EK ++ K
Sbjct: 839 KEECEKARQELQEAK 853
Score = 68.2 bits (165), Expect = 2e-11
Identities = 97/440 (22%), Positives = 194/440 (44%), Gaps = 58/440 (13%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE---TCLKIREQELKSLRSQLDVTHKE 74
L + + +E Q+ + ++ +G H +E + LK +EQ+LK + + + T ++
Sbjct: 521 LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD 580
Query: 75 -VGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE----LCILKRSYEKLQKKQMREFRGNT 129
L EE E +E KQ L+ L +E L IL++ + + + T
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQ-LEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639
Query: 130 KNHREDRS---EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE---AQRKALAEQSEI 183
+ RE ++E L A +E RQ+ + + Q + Q+ S + +++ +A++ +
Sbjct: 640 QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
Query: 184 IQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMT 243
+Q QL K+ L+ + S + E + + LE C +EL+ E +
Sbjct: 700 LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR--CISELKAETRS------------ 745
Query: 244 VLQEQQQKEEKLRESEK------------LLEALQEE----KRELKAALQSQ-------E 280
L EQ ++E K E E+ L EA Q E +REL A+ +Q E
Sbjct: 746 -LVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE 804
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNN 340
L+ E +E+ ++ + A+ L ++ C++ QEL E E++ +E+H+
Sbjct: 805 QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS- 863
Query: 341 EYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLR 400
+ +I + + ++ + + + AL+ ++ E Q+L T+ ++S RL
Sbjct: 864 --ELQISRQQNELAELHANLARALQQVQ-EKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Query: 401 AEMQKA-EDKAVEHKEILDQ 419
++KA E + +E++ +
Sbjct: 921 TLVRKAGEQQETASRELVKE 940
Score = 65.1 bits (157), Expect = 1e-10
Identities = 130/564 (23%), Positives = 223/564 (39%), Gaps = 144/564 (25%)
Query: 9 QNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE---QELKSLR 65
Q RG L +A EL ++ + ++ E+ AL L +E QEL LR
Sbjct: 1011 QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLR 1070
Query: 66 SQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
G+ Q++E E E +Q +K+L E+L K+ +E
Sbjct: 1071 ----------GLEAAQIKELE--------ELRQTVKQLKEQLA-----------KKEKEH 1101
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE----AQRKALAEQS 181
+ E E K+E R + E+Q Q+Q SLE A+R + AE+
Sbjct: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERD 1161
Query: 182 ---EIIQAQLVNRKQKL---ESVELSSQSEIQHLSSKL---------------------E 214
E +Q QL + Q+L +S S+Q E+ +K+ E
Sbjct: 1162 SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
Query: 215 RANDTICANELEIERLTMRVNDLVGTSMTV---LQEQQQKEEKLRESEKLLEA------- 264
R N I + E E+ L +V + G S + + + +K +KL E +LL+A
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
Query: 265 ---------------LQEE-----------KRELKAALQSQENLIHEARIQKEKLQEKVK 298
L+EE ++EL + + E L E + +EK +K +
Sbjct: 1282 RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
A +T + LE S + L EL+ ++++A E A K+ +E++ Q +Q
Sbjct: 1342 ALST------LQLEHTST--QALVSELLPAKHLCQQLQA---EQAAAEKRHREELEQSKQ 1390
Query: 359 SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 418
A G++ E+ +EL G + +++ + + A+ E +
Sbjct: 1391 ----AAGGLRAELLRAQREL-----------GELIPLRQKVAEQERTAQQLRAEKASYAE 1435
Query: 419 QLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEE--ELRSHHILE----R 472
QL LK + L+E GL E ++ +FLE E + R ++ E R
Sbjct: 1436 QLSMLKKAHGLLAEE----NRGLGE-------RANLGRQFLEVELDQAREKYVQELAAVR 1484
Query: 473 LDA--HIEELKRESEKTVRQFTAL 494
DA + E++RE++ T R+ +
Sbjct: 1485 ADAETRLAEVQREAQSTARELEVM 1508
Score = 63.5 bits (153), Expect = 4e-10
Identities = 92/429 (21%), Positives = 177/429 (41%), Gaps = 49/429 (11%)
Query: 66 SQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
S L + H L ++ + + Q++ E K+ EEL K++ L+ + +R
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQ 1403
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
R + E+ L K+ E + + ++ Y +Q+S L+ LAE++ +
Sbjct: 1404 R--------ELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLG 1455
Query: 186 AQLVNRKQKLESVELSSQSE--IQHLSSKLERANDTICANELEIERLTMRVNDLV----G 239
+ +Q LE VEL E +Q L++ A + + E + + + G
Sbjct: 1456 ERANLGRQFLE-VELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 240 TSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
+ VL+E+Q+ QEE+++L A ++ E E Q E+L +K+
Sbjct: 1515 AKVKVLEERQR--------------FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1560
Query: 300 TNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQS 359
++ V+ L++V A + QE +L ++A ++ + + K Q+ + +
Sbjct: 1561 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1620
Query: 360 YSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 419
Y + K + L ++L + K ++ E RL E+Q+A K E ++
Sbjct: 1621 Y----DAKKQQNQELQEQLRSLEQLQKENKELRAEAE-RLGHELQQAGLKTKEAEQTC-- 1673
Query: 420 LESLKLENRHLSEMVMKLELGLHECSLPVSPLG--SIATRFLEEEELRSHHILERLDAHI 477
RHL+ V LE + + LG +AT L+ E ++ +LD I
Sbjct: 1674 --------RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAK---PQLDLSI 1722
Query: 478 EELKRESEK 486
+ L E+
Sbjct: 1723 DSLDLSCEE 1731
Score = 59.3 bits (142), Expect = 8e-09
Identities = 96/503 (19%), Positives = 209/503 (41%), Gaps = 73/503 (14%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ E+E ++L+K+ VA + +E + +++L +L+ + + +E+
Sbjct: 798 TAESECEQLVKE----VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMR--EFRGNTKNHREDRS 137
++V E + + EL +LH L R+ +++Q+K++R + + +E +
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLA---RALQQVQEKEVRAQKLADDLSTLQEKMA 910
Query: 138 EIERLTAKIEEFRQKSLDWEK--QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL 195
+ A++E +K+ + ++ R + ++ + + Q + L EQ Q + + L
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG---RQFCSTQAAL 967
Query: 196 ESVELSSQ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+++E ++ +E++ L + L + + ER R+ G + L ++
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLE 312
+L +L AL E++ E QE L H ++ K QE K + A + LE
Sbjct: 1028 AELEM--RLQNALNEQRVEFATL---QEALAHALTEKEGKDQELAKLRGLE-AAQIKELE 1081
Query: 313 SVSATCKQLSQELMEKYEELKRMEAHNNE--------------YKAEIKKLKEQILQGEQ 358
+ T KQL ++L +K +E +E +AE+ KL++Q + ++
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
Query: 359 SYSSALEGMKME----------ISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAED 408
S ++ E + L +L ++ + ++ + + ++ L A K +D
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 409 KAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHH 468
+ E Q+ + E + ++ LE EE + +
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLE---------------------EEVSILNRQ 1240
Query: 469 ILERLDAHIEELKR----ESEKT 487
+LE+ + +ELKR ESEK+
Sbjct: 1241 VLEK-EGESKELKRLVMAESEKS 1262
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 91.3 bits (225), Expect = 2e-18
Identities = 105/475 (22%), Positives = 202/475 (42%), Gaps = 45/475 (9%)
Query: 59 QELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTM-----EYKQELKKLHEELCILKRS 113
+E++ +R + + + G L Q E+ +++ E E ++ LK + + +
Sbjct: 36 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 95
Query: 114 YEKLQKKQMREFRGNTKNHREDRSEIERLTA-------KIEEFRQKSLDWEKQRLIYQQQ 166
EK ++ E K E R E ++L K + F ++ LD K+ ++ +
Sbjct: 96 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 155
Query: 167 VSSLEAQRKALAEQSEIIQAQ-LVNRKQ--KLESVELSSQSEIQHLSSKLERANDTICAN 223
SL+A ++ A+ + Q Q + RK KL++ Q E L K ++ +
Sbjct: 156 --SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIA 213
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKREL----------K 273
E ++ L +++D M +L + ++ E +L + E LQ++ +L +
Sbjct: 214 ENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR---ERLQQQASDLVLKASHIGMLQ 270
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK 333
A +QE I + +K ++ E++ + A +S+ KQ EL +K E K
Sbjct: 271 ATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAK 330
Query: 334 R--MEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGS 391
R E + E K +L+E++ Q +++S LE + + + +H I K
Sbjct: 331 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSN--AIRDKKKL 388
Query: 392 SSDMEKR-------LRAEMQKAEDKAVEHKEIL-DQLESLKLENRHLSEMVMKLELGLHE 443
D+E++ L + + + + KE+L D+L + E HL +MV K E GL
Sbjct: 389 QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 448
Query: 444 CSLPVSPLGSIATRFLEEEELRSHHILERLDAHIE---ELKRESEKTVRQFTALK 495
++ L R E +L + E DA + EL++E ++ A+K
Sbjct: 449 AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMK 503
Score = 84.0 bits (206), Expect = 3e-16
Identities = 114/500 (22%), Positives = 215/500 (43%), Gaps = 65/500 (13%)
Query: 17 FLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVG 76
FL S L E KQ + + K +E A T + E+ELK+L+S+L+ +EV
Sbjct: 303 FLRSKTQSLDEEQKQQILELEKKVNE------AKRTQQEYYERELKNLQSRLE---EEVT 353
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDR 136
L+ E H K +E+ ++ ++ +H R +KLQ + + N ED+
Sbjct: 354 QLN---EAHSKTLEELAWKHHMAIEAVHSNAI---RDKKKLQMDLEEQHNKDKLNLEEDK 407
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIY--------QQQVSSLEAQRKALAEQSEIIQAQL 188
+++++ ++E + L+ Q + + +Q + S E +L + E +Q +L
Sbjct: 408 NQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNEL 467
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICA----NELEIER----LTMRVNDLVGT 240
K L+ + + + L + ++ +TI A +L++++ L ++ + +
Sbjct: 468 DLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQ 527
Query: 241 SMTVLQEQ---QQKEEKLRESEKLLEALQEEKRELKAALQSQ-ENLIHEARIQKEKLQEK 296
+ L+E+ Q +E+K +LL+ EK + + Q + E+L+++ + K+ L+ +
Sbjct: 528 ECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQ 587
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
+ + T SL+ + A Q Q L ++ EEL+ ++ E L Q ++
Sbjct: 588 LSQSQT-------SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE 640
Query: 357 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 416
E+ ++ H + +D S +G +ME+ L+ + ED E K +
Sbjct: 641 EKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELED---EGKAM 697
Query: 417 LDQLES-----------LKLENRHLSEMVMKLELGLHECSLPVSPLGS-----IATRFLE 460
L L S L N H K+EL E S+ +S S T E
Sbjct: 698 LASLRSELNHQHAAAIDLLRHNHHQELAAAKMEL---ERSIDISRRQSKEHICRITDLQE 754
Query: 461 EEELRSHHILERLDAHIEEL 480
E R HHI E LD ++ L
Sbjct: 755 ELRHREHHISE-LDKEVQHL 773
Score = 72.4 bits (176), Expect = 9e-13
Identities = 76/391 (19%), Positives = 170/391 (43%), Gaps = 37/391 (9%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
L+ +E +K L S+ ++ + L ++ Q + E KQ++ +L +++
Sbjct: 269 LQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNE 328
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLD---WEKQRLIYQQQ 166
KR+ ++ +++++ + S +E ++ E K+L+ W+ I
Sbjct: 329 AKRTQQEYYERELKNLQ----------SRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVH 378
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE 226
+++ ++K + E Q K LE + Q E+++L LE +T
Sbjct: 379 SNAIRDKKKLQMDLEE----QHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGH 434
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQS------QE 280
++ + + +G++ ++ Q +E+L+ L+ ++ +E K AL + QE
Sbjct: 435 LQDMVRKSEQGLGSAEGLIASLQDSQERLQNE---LDLTKDSLKETKDALLNVEGELEQE 491
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNN 340
HE I K +EK+K H +E E++ C +L +EL ++EE K+
Sbjct: 492 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK------ 545
Query: 341 EYKAEIKKLKEQILQ-GEQSYSSALEGMKMEISHLTQ----ELHQRDITIASTKGSSSDM 395
+++ +LK++ S+ +E + +IS L Q +L Q ++ + +
Sbjct: 546 SAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 605
Query: 396 EKRLRAEMQKAEDKAVEHKEILDQLESLKLE 426
+RL E+++ E++ + + L + L +
Sbjct: 606 RQRLTQELEELEEQHQQRHKSLKEAHVLAFQ 636
Score = 72.0 bits (175), Expect = 1e-12
Identities = 106/502 (21%), Positives = 221/502 (44%), Gaps = 62/502 (12%)
Query: 35 MVAHKKSEWEGRTHALETCLKIREQELKSLRSQL-DVTHKEVGMLHQQVEEHEKIKQEMT 93
MV + + L+T L I E ++ L+ QL D E+ +L +H++++ E+
Sbjct: 191 MVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL----SKHKEVESELA 246
Query: 94 MEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR--- 150
++ L++ +L + LQ QM + K+ ++S + +++EE R
Sbjct: 247 AA-RERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQLEEERAFL 304
Query: 151 ---QKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSE-- 205
+SLD E+++ I + + EA+R Q E + +L N + +LE E++ +E
Sbjct: 305 RSKTQSLDEEQKQQILELEKKVNEAKR----TQQEYYERELKNLQSRLEE-EVTQLNEAH 359
Query: 206 ---IQHLSSKLERANDTICANEL-EIERLTMRVNDLVGTSMTVLQEQQQK---------- 251
++ L+ K A + + +N + + ++L M + + L+E + +
Sbjct: 360 SKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKE 419
Query: 252 --EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI 309
E+KL + + + LQ+ R+ + L S E LI + +E+LQ ++ T
Sbjct: 420 VLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKD 479
Query: 310 SLESVSATCKQLSQELMEKYEELKRME-------AHNNEYK------AEIKKLKEQI-LQ 355
+L +V +Q Q+ E +K E AH+ E K E KL+E++ LQ
Sbjct: 480 ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQ 539
Query: 356 GEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE 415
E+ SA+ + L + +++ S + D+ ++ Q E + + +
Sbjct: 540 HEEDKKSAMSQL------LQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQT 593
Query: 416 ILDQLES-LKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELR-----SHHI 469
L QL++ E + L++ + +LE + + +A + +EEE+ + +H+
Sbjct: 594 SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 653
Query: 470 LERLDAHIEELKRESEKTVRQF 491
++ A ++ LK +++ F
Sbjct: 654 QQKHSAELQSLKDAHRESMEGF 675
Score = 60.8 bits (146), Expect = 3e-09
Identities = 82/379 (21%), Positives = 158/379 (41%), Gaps = 27/379 (7%)
Query: 9 QNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQL 68
Q G G + S + + L ++D+ K S E + L E EL+ R Q
Sbjct: 444 QGLGSAEGLIASLQDSQERLQNELDLT---KDSLKETKDALLNV-----EGELEQERQQH 495
Query: 69 DVT---HKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
+ T KE L H+ ++ + T +QE KL EEL + +K Q+ +
Sbjct: 496 EETIAAMKEEEKLKVDKMAHD-LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 554
Query: 126 RGNTKNHRED--RSEIERLTAKIEEFRQK-SLDWEKQRLIYQQQVSSLEAQRKALAEQSE 182
+ KN D + ++E L +I +Q + + + QQ + +R+ L ++ E
Sbjct: 555 KDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELE 614
Query: 183 IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM 242
++ Q R + L+ + + ++ K +RA + + E +++ D SM
Sbjct: 615 ELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLK--DAHRESM 672
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT 302
+ + ++E + E L++E + + A+L+S+ N H A I + +
Sbjct: 673 EGFRIEMEQELQTLRFE-----LEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 727
Query: 303 QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 362
+ +E S++ K+ + + EEL+ E H +E E++ L E I + +
Sbjct: 728 KMELER-SIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENI----SALTK 782
Query: 363 ALEGMKMEISHLTQELHQR 381
LE EI + E +Q+
Sbjct: 783 ELEFKGKEILRIRSESNQQ 801
Score = 43.1 bits (100), Expect = 6e-04
Identities = 55/217 (25%), Positives = 100/217 (46%), Gaps = 42/217 (19%)
Query: 220 ICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL-----------LEALQ-E 267
+CA ++R+ V S V + +++ EEKLR +L LE LQ
Sbjct: 21 LCAEAQHVQRI-------VTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAA 73
Query: 268 EKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+RE++ L+SQ++ H A + K QEK + H +E SL + + ++L+E
Sbjct: 74 HRREIQELLKSQQD--HSASVNKG--QEKAEEL---HRMEVESLNKMLEELRLERKKLIE 126
Query: 328 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAS 387
YE ++ + Y+ E+ LK L +S L+ K + + L +E ++ +
Sbjct: 127 DYE--GKLNKAQSFYERELDTLKRSQLFTAES----LQASKEKEADLRKEFQGQEAILRK 180
Query: 388 TKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
T G +L+ E+Q +D+A +LD+ + L+
Sbjct: 181 TIG-------KLKTELQMVQDEA---GSLLDKCQKLQ 207
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 91.3 bits (225), Expect = 2e-18
Identities = 105/475 (22%), Positives = 202/475 (42%), Gaps = 45/475 (9%)
Query: 59 QELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTM-----EYKQELKKLHEELCILKRS 113
+E++ +R + + + G L Q E+ +++ E E ++ LK + + +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 215
Query: 114 YEKLQKKQMREFRGNTKNHREDRSEIERLTA-------KIEEFRQKSLDWEKQRLIYQQQ 166
EK ++ E K E R E ++L K + F ++ LD K+ ++ +
Sbjct: 216 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 275
Query: 167 VSSLEAQRKALAEQSEIIQAQ-LVNRKQ--KLESVELSSQSEIQHLSSKLERANDTICAN 223
SL+A ++ A+ + Q Q + RK KL++ Q E L K ++ +
Sbjct: 276 --SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIA 333
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKREL----------K 273
E ++ L +++D M +L + ++ E +L + E LQ++ +L +
Sbjct: 334 ENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR---ERLQQQASDLVLKASHIGMLQ 390
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK 333
A +QE I + +K ++ E++ + A +S+ KQ EL +K E K
Sbjct: 391 ATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAK 450
Query: 334 R--MEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGS 391
R E + E K +L+E++ Q +++S LE + + + +H I K
Sbjct: 451 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSN--AIRDKKKL 508
Query: 392 SSDMEKR-------LRAEMQKAEDKAVEHKEIL-DQLESLKLENRHLSEMVMKLELGLHE 443
D+E++ L + + + + KE+L D+L + E HL +MV K E GL
Sbjct: 509 QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 568
Query: 444 CSLPVSPLGSIATRFLEEEELRSHHILERLDAHIE---ELKRESEKTVRQFTALK 495
++ L R E +L + E DA + EL++E ++ A+K
Sbjct: 569 AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMK 623
Score = 84.0 bits (206), Expect = 3e-16
Identities = 114/500 (22%), Positives = 215/500 (43%), Gaps = 65/500 (13%)
Query: 17 FLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVG 76
FL S L E KQ + + K +E A T + E+ELK+L+S+L+ +EV
Sbjct: 423 FLRSKTQSLDEEQKQQILELEKKVNE------AKRTQQEYYERELKNLQSRLE---EEVT 473
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDR 136
L+ E H K +E+ ++ ++ +H R +KLQ + + N ED+
Sbjct: 474 QLN---EAHSKTLEELAWKHHMAIEAVHSNAI---RDKKKLQMDLEEQHNKDKLNLEEDK 527
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIY--------QQQVSSLEAQRKALAEQSEIIQAQL 188
+++++ ++E + L+ Q + + +Q + S E +L + E +Q +L
Sbjct: 528 NQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNEL 587
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICA----NELEIER----LTMRVNDLVGT 240
K L+ + + + L + ++ +TI A +L++++ L ++ + +
Sbjct: 588 DLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQ 647
Query: 241 SMTVLQEQ---QQKEEKLRESEKLLEALQEEKRELKAALQSQ-ENLIHEARIQKEKLQEK 296
+ L+E+ Q +E+K +LL+ EK + + Q + E+L+++ + K+ L+ +
Sbjct: 648 ECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQ 707
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
+ + T SL+ + A Q Q L ++ EEL+ ++ E L Q ++
Sbjct: 708 LSQSQT-------SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE 760
Query: 357 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 416
E+ ++ H + +D S +G +ME+ L+ + ED E K +
Sbjct: 761 EKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELED---EGKAM 817
Query: 417 LDQLES-----------LKLENRHLSEMVMKLELGLHECSLPVSPLGS-----IATRFLE 460
L L S L N H K+EL E S+ +S S T E
Sbjct: 818 LASLRSELNHQHAAAIDLLRHNHHQELAAAKMEL---ERSIDISRRQSKEHICRITDLQE 874
Query: 461 EEELRSHHILERLDAHIEEL 480
E R HHI E LD ++ L
Sbjct: 875 ELRHREHHISE-LDKEVQHL 893
Score = 72.4 bits (176), Expect = 9e-13
Identities = 76/391 (19%), Positives = 170/391 (43%), Gaps = 37/391 (9%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
L+ +E +K L S+ ++ + L ++ Q + E KQ++ +L +++
Sbjct: 389 LQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNE 448
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLD---WEKQRLIYQQQ 166
KR+ ++ +++++ + S +E ++ E K+L+ W+ I
Sbjct: 449 AKRTQQEYYERELKNLQ----------SRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVH 498
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE 226
+++ ++K + E Q K LE + Q E+++L LE +T
Sbjct: 499 SNAIRDKKKLQMDLEE----QHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGH 554
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQS------QE 280
++ + + +G++ ++ Q +E+L+ L+ ++ +E K AL + QE
Sbjct: 555 LQDMVRKSEQGLGSAEGLIASLQDSQERLQNE---LDLTKDSLKETKDALLNVEGELEQE 611
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNN 340
HE I K +EK+K H +E E++ C +L +EL ++EE K+
Sbjct: 612 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK------ 665
Query: 341 EYKAEIKKLKEQILQ-GEQSYSSALEGMKMEISHLTQ----ELHQRDITIASTKGSSSDM 395
+++ +LK++ S+ +E + +IS L Q +L Q ++ + +
Sbjct: 666 SAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 725
Query: 396 EKRLRAEMQKAEDKAVEHKEILDQLESLKLE 426
+RL E+++ E++ + + L + L +
Sbjct: 726 RQRLTQELEELEEQHQQRHKSLKEAHVLAFQ 756
Score = 72.0 bits (175), Expect = 1e-12
Identities = 106/502 (21%), Positives = 221/502 (44%), Gaps = 62/502 (12%)
Query: 35 MVAHKKSEWEGRTHALETCLKIREQELKSLRSQL-DVTHKEVGMLHQQVEEHEKIKQEMT 93
MV + + L+T L I E ++ L+ QL D E+ +L +H++++ E+
Sbjct: 311 MVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALL----SKHKEVESELA 366
Query: 94 MEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR--- 150
++ L++ +L + LQ QM + K+ ++S + +++EE R
Sbjct: 367 AA-RERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQLEEERAFL 424
Query: 151 ---QKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSE-- 205
+SLD E+++ I + + EA+R Q E + +L N + +LE E++ +E
Sbjct: 425 RSKTQSLDEEQKQQILELEKKVNEAKR----TQQEYYERELKNLQSRLEE-EVTQLNEAH 479
Query: 206 ---IQHLSSKLERANDTICANEL-EIERLTMRVNDLVGTSMTVLQEQQQK---------- 251
++ L+ K A + + +N + + ++L M + + L+E + +
Sbjct: 480 SKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKE 539
Query: 252 --EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI 309
E+KL + + + LQ+ R+ + L S E LI + +E+LQ ++ T
Sbjct: 540 VLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKD 599
Query: 310 SLESVSATCKQLSQELMEKYEELKRME-------AHNNEYK------AEIKKLKEQI-LQ 355
+L +V +Q Q+ E +K E AH+ E K E KL+E++ LQ
Sbjct: 600 ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQ 659
Query: 356 GEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE 415
E+ SA+ + L + +++ S + D+ ++ Q E + + +
Sbjct: 660 HEEDKKSAMSQL------LQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQT 713
Query: 416 ILDQLES-LKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELR-----SHHI 469
L QL++ E + L++ + +LE + + +A + +EEE+ + +H+
Sbjct: 714 SLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 773
Query: 470 LERLDAHIEELKRESEKTVRQF 491
++ A ++ LK +++ F
Sbjct: 774 QQKHSAELQSLKDAHRESMEGF 795
Score = 66.6 bits (161), Expect = 5e-11
Identities = 95/441 (21%), Positives = 179/441 (40%), Gaps = 35/441 (7%)
Query: 9 QNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQL 68
Q G G + S + + L ++D+ K S E + L E EL+ R Q
Sbjct: 564 QGLGSAEGLIASLQDSQERLQNELDLT---KDSLKETKDALLNV-----EGELEQERQQH 615
Query: 69 DVT---HKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
+ T KE L H+ ++ + T +QE KL EEL + +K Q+ +
Sbjct: 616 EETIAAMKEEEKLKVDKMAHD-LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 674
Query: 126 RGNTKNHRED--RSEIERLTAKIEEFRQK-SLDWEKQRLIYQQQVSSLEAQRKALAEQSE 182
+ KN D + ++E L +I +Q + + + QQ + +R+ L ++ E
Sbjct: 675 KDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELE 734
Query: 183 IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM 242
++ Q R + L+ + + ++ K +RA + + E +++ D SM
Sbjct: 735 ELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLK--DAHRESM 792
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT 302
+ + ++E + E L++E + + A+L+S+ N H A I + +
Sbjct: 793 EGFRIEMEQELQTLRFE-----LEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 847
Query: 303 QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 362
+ +E S++ K+ + + EEL+ E H +E E++ L E I + +
Sbjct: 848 KMELER-SIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENI----SALTK 902
Query: 363 ALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 422
LE EI + E +Q+ + D+ KRL E+ + K I+
Sbjct: 903 ELEFKGKEILRIRSESNQQ------IRLHEQDLNKRLEKELDVMTADHLREKNIM--RAD 954
Query: 423 LKLENRHLSEMVMKLELGLHE 443
N L E+ L++ L E
Sbjct: 955 FNKTNELLKEINAALQVSLEE 975
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 90.9 bits (224), Expect = 2e-18
Identities = 108/453 (23%), Positives = 199/453 (43%), Gaps = 31/453 (6%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
+QEL++ R Q K+ L ++ + HE Q+M + L++L E+L KR L
Sbjct: 1165 QQELRTKREQEVAELKKA--LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 118 QKKQMREFRGNTKNHREDRSEIERLT-AKIE-EFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
+K + +G +++E E++ L K E E ++K LD + Q L +VS + R
Sbjct: 1223 EKNK----QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL--HAKVSEGDRLRV 1276
Query: 176 ALAEQSEIIQAQLVNRKQKLESVE---LSSQSEIQHLSSKLERANDTICANELEIERLTM 232
LAE++ +Q +L N LE E + + L S+L+ + + + L+
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 233 RVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK 292
R+ L ++ ++Q+++EE + EK + ALQ + + K + I K+K
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 293 LQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEEL--KRMEAHNNEYKAEIKKLK 350
L + +A + + +A++ + + T +L QEL + +L +R A N E K +K
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK---QKKF 1453
Query: 351 EQILQGEQSYSSALEGMKMEISHLTQELHQRDITIA-------STKGSSSDMEKRLRAEM 403
+Q+L E+S S+ + +E + +++A K K+LRA+M
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 404 QKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRF---LE 460
ED ++ + L+ R L + V ++ L E + R ++
Sbjct: 1514 ---EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 461 EEELRSHHILERLDAHIEELKRESEKTVRQFTA 493
+ + L+ D EE KR K VR+ A
Sbjct: 1571 AMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603
Score = 82.8 bits (203), Expect = 7e-16
Identities = 93/473 (19%), Positives = 199/473 (42%), Gaps = 58/473 (12%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
A++++LM K + H LE + EQ+++ +R+QL+ E+
Sbjct: 1511 ADMEDLMSS--------KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
E Q M +++++L+ E+ ++L KQ+RE ++ R+ R+ +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEAELEDERKQRA-LAVA 1617
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS 202
+ K E K L+ Q+ + R + +Q +QAQ+ + +++LE +S
Sbjct: 1618 SKKKMEIDLKDLE---------AQIEAANKARDEVIKQLRKLQAQMKDYQRELEEAR-AS 1667
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL 262
+ EI S + E+ ++ E EI +L + QE+ + +++ S
Sbjct: 1668 RDEIFAQSKESEKKLKSL---EAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 263 EALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLS 322
AL +EKR L+A + E + E + E L ++ + T Q +++++A
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ-------VDTLNAELAAER 1777
Query: 323 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 382
+ +++E N E KA++++L+ + + + + + ++ +I L ++L Q
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAV---KSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 383 ITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLH 442
A+ EK+L+ + ED+ + +Q+E N + ++ +LE
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK---ANARMKQLKRQLEEA-- 1889
Query: 443 ECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 495
EEE R++ +L +++ +E R+ + LK
Sbjct: 1890 -----------------EEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
Score = 72.0 bits (175), Expect = 1e-12
Identities = 98/475 (20%), Positives = 203/475 (42%), Gaps = 40/475 (8%)
Query: 40 KSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEV-GMLHQQVEE--HEKIKQEMTMEY 96
K + +G T L+ + + ++ L+ QL +E+ G L + +E H+ ++ E
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 97 KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW 156
+ ++ +L E+ K S K +K++ R+ E+E L ++E+ +
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQK-----------RDLSEELEALKTELEDTLDTTAAQ 1165
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV--ELSSQSE-IQHLSSKL 213
++ R +Q+V+ L +KAL E+++ +AQ+ + +Q+ + ELS Q E + + L
Sbjct: 1166 QELRTKREQEVAEL---KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 214 ERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELK 273
E+ + E + + L V L V E + K +KL + L A E L+
Sbjct: 1223 EKNKQGL---ETDNKELACEVKVL----QQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK 333
L + + + L E+ + + A +A SLES ++L QE + L
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 334 RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 393
E K +++ +E+ + ++ + ++ +++ +++ TI S + +
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 394 DMEKRLRAEMQKAEDKAVEH-------KEILDQLESLKLENRHLSEMVMKLELGLHECSL 446
+ K A Q+ E+KA+ + + +L+ L ++ H ++ LE +
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 447 PVSPLGSIATRFLEEEELRSHHILER------LDAHIEELKRESEKTVRQFTALK 495
++ SI+ R+ EE + E+ L +EE E+ RQ L+
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510
Score = 61.2 bits (147), Expect = 2e-09
Identities = 83/350 (23%), Positives = 155/350 (44%), Gaps = 49/350 (14%)
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQL--VNRKQKLESVELSSQSEIQHLSSKLERANDTIC 221
QQQ+S+L+ ++ A ++ Q V K K + E+Q +L + +
Sbjct: 810 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQT 869
Query: 222 ANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQEN 281
E E+E + + L+ + ++ Q + E E+E++ L +K+EL+ L E+
Sbjct: 870 KVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES 929
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNE 341
+ E + + LQ + K + A + L ++L E+ ++++
Sbjct: 930 RVEEEEERNQILQNEKK--------------KMQAHIQDLEEQLDEEEGARQKLQLEKVT 975
Query: 342 YKAEIKKLKEQILQGEQSYSSALEGMKM------EISHLTQELHQRDITIASTKGSS--- 392
+A+IKK++E+IL E S ++ K+ E S E ++ +A +
Sbjct: 976 AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035
Query: 393 -SDMEKRL------RAEMQKAEDKA-VEHKEILDQLESLKLENRHLSEMVMKLELGLHEC 444
SD+E+RL R E++KA+ K E ++ DQ+ L+ + L KL+L E
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL-----KLQLAKKEE 1090
Query: 445 SLPVSPLGSIATRFLEEEELRSHH---ILERLDAHIEELKR--ESEKTVR 489
L G++A ++E L ++ ++ L A I EL+ ESEK R
Sbjct: 1091 ELQ----GALARG--DDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Score = 51.2 bits (121), Expect = 2e-06
Identities = 81/396 (20%), Positives = 162/396 (40%), Gaps = 64/396 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EAEL++ KQ + VA KK +E LK E ++++ D K++ L Q
Sbjct: 1602 EAELEDERKQRALAVASKKK--------MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 82 VEEHEKIKQE----------MTMEYKQELKKLHEELCILKRSYEKLQK------KQMREF 125
++++++ +E + E +++LK L E+ L+ ++ ++ E
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 126 RGNTKNHREDRS----EIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL 177
N +S E RL A+I EE ++ + E +++ ++ L
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAEL 1773
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLE-RANDTICANELEIERLTMRVND 236
A + Q N +Q+LE ++++Q L ++ + TI A E +I +L ++
Sbjct: 1774 AAERSAAQKS-DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEK 296
+ ++ E+KL+E +E + + K ++ + + + Q E+ +E+
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 356
N A+ ++L +EL + E N E+ LK ++ +G
Sbjct: 1893 ATRAN--------------ASRRKLQRELDDATEA-------NEGLSREVSTLKNRLRRG 1931
Query: 357 EQ-SYSSA--------LEGMKMEISHLTQELHQRDI 383
S+SS+ LEG +E+S E D+
Sbjct: 1932 GPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDV 1967
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 88.2 bits (217), Expect = 2e-17
Identities = 86/395 (21%), Positives = 184/395 (46%), Gaps = 57/395 (14%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
K EWE + E KIREQE K +R Q + ++ M+ ++ EE + ++EM E ++
Sbjct: 369 KIQEWEEKIQEQEE--KIREQEEK-IREQEEKMRRQEEMMWEK-EEKMRRQEEMMWEKEE 424
Query: 99 ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
++++ E + + +L++K + + + E R E E++ + + Q++ W +
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEK--IREQEEKRQEEEKIREQEKRQEQEAKMWRQ 482
Query: 159 QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVE--------LSSQSEIQHLS 210
+ I +Q+ E + K ++ +I + + + ++K + E + Q EI
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 542
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQ 266
K+ + I E ++ R +++D ++EQ++K EEK+RE E+ + +
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHD----QEEKIREQEEKVWRQEEKIREQEEKIREQE 598
Query: 267 EEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELM 326
E+ RE + Q QE + E Q+EK+ C+Q +++
Sbjct: 599 EKIREQEEMTQEQEEKMGE---QEEKM------------------------CEQ-EEKMQ 630
Query: 327 EKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM---KMEISHLTQELHQRDI 383
E+ E+++R E E + +I++ +E+I + E+ E M + ++ +++ +++
Sbjct: 631 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 384 TIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 418
+ + + E RLR + E+K EH+E L+
Sbjct: 691 KMRRQEEKMWEQEVRLRQQ----EEKMQEHQEHLE 721
Score = 69.7 bits (169), Expect = 6e-12
Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 35/304 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 437 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 491
Query: 62 KSLRSQLDVTHKEVGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHEELCILKRSY----E 115
K +R Q + ++ +H+Q + E EK +++ M ++E + EE+ K E
Sbjct: 492 K-IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 116 KLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
K++K++ + +R K H ++ KI E +K W ++ I +Q+ + Q +
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEE--------KIREQEEKV--WRQEEKIREQE-EKIREQEE 599
Query: 176 ALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVN 235
+ EQ E+ Q Q ++ E + + ++Q K+ R + I E +I ++
Sbjct: 600 KIREQEEMTQEQEEKMGEQEEKM-CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 236 DLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKE 291
+ ++QEQ++K EEK+ E E+ ++ +E+ R + + QE + R Q+E
Sbjct: 659 E----QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL---RQQEE 711
Query: 292 KLQE 295
K+QE
Sbjct: 712 KMQE 715
Score = 68.9 bits (167), Expect = 1e-11
Identities = 98/480 (20%), Positives = 205/480 (42%), Gaps = 65/480 (13%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 163 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 222
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 223 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 282
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 283 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 341 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 379
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+ ++ QE I E R Q+E + EK + Q + E + ++ + + E
Sbjct: 380 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM----RRQEEMMWE 435
Query: 328 KYEELKRME---------AHNNEYKAEIKKLKEQILQGEQS-----YSSALEGMKMEISH 373
K E+++ +E E + E +K++EQ + EQ + + +I
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLEN---RHL 430
+++ +++ I + + +++ + EM + E+K E +EI Q E + + R
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555
Query: 431 SEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
E + + E +H+ + R +EE++R E++ E+++ + E T Q
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWR--QEEKIREQE--EKIREQEEKIREQEEMTQEQ 611
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 87.8 bits (216), Expect = 2e-17
Identities = 105/476 (22%), Positives = 222/476 (46%), Gaps = 50/476 (10%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
+++ + ++ + + KSE+E + + E+ K L+ QL V + +++++
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 85 HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT----KNHREDRSEIE 140
+ ++E + + K EL + E+L I ++ K +K+ ++ +GN ++ + + +IE
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQL-IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 141 RLTA--KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA------EQSEIIQAQLVNRK 192
L KI ++ L+ + Q+ + Q L A+++ ++ E+S+ QL +
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQL-TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
ES L+++ +++ + KL A + + +N +I + +L T+ Q+ +KE
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHE-----ARIQKE--KLQEKVKATNTQHA 305
++L+E K L+ +Q+EK + L ++++ + E R +KE KL E++K+ +
Sbjct: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI 1155
Query: 306 VEAISLESVSATCKQLSQELMEKYEELK---RMEAHN-----NEYKAEIKKLKEQILQGE 357
E +L+ Q EL K + LK E N ++ K E ++LK++ ++ E
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKE 1215
Query: 358 QSYSSALE----GMK----------MEISHLTQELHQRDITIASTKGSSSDMEKR---LR 400
S ++ GMK M+I+ L + L S++ S++EK+ LR
Sbjct: 1216 AKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Query: 401 AEMQKAE----DKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLG 452
E+ E + E + +L++ + E L V++L+ L + V LG
Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG 1331
Score = 81.3 bits (199), Expect = 2e-15
Identities = 94/495 (18%), Positives = 207/495 (41%), Gaps = 36/495 (7%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L + +L+++++QI K E + + + E+E + L +++ E +
Sbjct: 504 LREAQNDLEQVLRQIGDK-DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L+Q E++ +++++T + ++LK E + + ++Q R +
Sbjct: 563 LNQLQEKNHTLQEQVT-QLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA----QRKALAEQSEIIQAQLVNRKQ 193
+ L +++ E ++K + Q + + S EA QR L + Q L +++Q
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681
Query: 194 KLESVELS----------SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMT 243
+L + Q L S L+ + + E + E L ++ L S+
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQ 303
V ++Q + L++ +L L+ EL L+ ++ ++ R+ +K E +++ +
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 304 HAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA 363
+ + + + LSQE ++EEL NN + + +L Q
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEEL------NNRIQTTVTEL--------QKVKME 847
Query: 364 LEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD-QLES 422
E + E+S + +L + ++ ++K ++ +A + E E K L Q+E+
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 423 LKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILE--RLDAHIEEL 480
E + L + + K + H+ L L S+ + ++ + + E +L +I EL
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKL---ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964
Query: 481 KRESEKTVRQFTALK 495
K+ SE+ +Q AL+
Sbjct: 965 KQSSEQKKKQIEALQ 979
Score = 79.7 bits (195), Expect = 6e-15
Identities = 98/435 (22%), Positives = 190/435 (43%), Gaps = 66/435 (15%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
++ L ++ + + L+S+L + + +H ++ E K E T + K+EL ++ +
Sbjct: 335 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE----KGEATQKLKEELSEVETKYQH 390
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR------------------Q 151
LK +++LQ Q RE + ++ + +SEI +L +K+ E +
Sbjct: 391 LKAEFKQLQ--QQREEK--EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE 446
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQS------- 204
K +D E+Q Q ++S LE Q K S +Q QL KQ+ + + QS
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 205 -----------------EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+IQ+L + L+++ + I E E E L ++ G + VL +
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET-AVLNQ 565
Query: 248 QQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL---QEKVKATNTQH 304
Q+K L+ E++ + ++ K + ++ Q+QENL + + QK L Q++V + T
Sbjct: 566 LQEKNHTLQ--EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
L QL ++ K E L EA +A+++ + + +AL
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD-------TAQNAL 676
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK---AEDKAVEHKEILDQLE 421
+ + E++ +T +L Q + + S +E L+ +K E K E + + +LE
Sbjct: 677 QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 422 SLKLENRHLSEMVMK 436
+ LE + E ++
Sbjct: 737 ADSLEVKASKEQALQ 751
Score = 76.6 bits (187), Expect = 5e-14
Identities = 94/400 (23%), Positives = 179/400 (44%), Gaps = 48/400 (12%)
Query: 136 RSEIERLTAKIEEFRQKSLDWEKQRLIYQ---QQ-------VSSLEAQRKALAEQSEIIQ 185
R E++ L A ++E + S + +K+ YQ QQ V+ A+ ++L +Q E Q
Sbjct: 89 RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ 148
Query: 186 AQLVNRKQKLESVELSSQ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM 242
+ N KQ + E + +EI + SK + A E ++ RLT +N
Sbjct: 149 TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK----EA 204
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT 302
TV+Q+ K E L+ +E + K+EL +N+ E + EKL+++ K +
Sbjct: 205 TVIQDL--KTELLQRPG--IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
Query: 303 QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 362
Q+A ++ + + + QE+ +EL+++++ NE + + L E +L+ EQ Y+
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 363 ALEGMKMEI---SHLTQELHQRDI---TIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 416
E E ++ LHQ+D+ + S +S R+ E+ + + + KE
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
Query: 417 LDQLES----LKLENRHLSE---------MVMKLELG-LHECSLPVS-PLGSIATRFLEE 461
L ++E+ LK E + L + + ++ E+ LH L LG R E+
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
Query: 462 EELRSHHILER------LDAHIEELKRESEKTVRQFTALK 495
+L S ++++ L + L+ + ++ V T L+
Sbjct: 441 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Score = 73.2 bits (178), Expect = 5e-13
Identities = 100/495 (20%), Positives = 221/495 (44%), Gaps = 65/495 (13%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
++Q LM + + + + + L++ E + LRS+L +EV + V+
Sbjct: 232 QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAV---YVQ 288
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
E +K+K + E Q+ + L E L ++ Y KL++K H E+ + +
Sbjct: 289 ELQKLKSSVN-ELTQKNQTLTENLLKKEQDYTKLEEK-----------HNEESVSKKNIQ 336
Query: 144 AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQ 203
A + QK LD ++ + +SL L+E+ E Q K++L VE
Sbjct: 337 ATL---HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ----KLKEELSEVE---- 385
Query: 204 SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQ--------KEEKL 255
++ QHL ++ ++ E +L +N L +L+ ++Q KE++
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL---HSKLLETERQLGEAHGRLKEQRQ 442
Query: 256 RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVS 315
SEKL++ +++ +L+ L E + E +LQ ++ T QH + +S +
Sbjct: 443 LSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501
Query: 316 ATCK-------QLSQELMEKYEELKRMEAHNNEYKAEIKKL---------KEQILQGEQS 359
A + Q+ +++ +K ++++ +EA + K I L K Q +GE +
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 360 YSSALE----GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE 415
+ L+ ++ +++ LT++L + + + + D + +A ++ A+D+ + +
Sbjct: 562 VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Query: 416 ILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDA 475
+++L S E++ E V +L++ + + + L + A + + +L++H L+
Sbjct: 622 SVNELNSQLNESK---EKVSQLDIQIKAKTELL--LSAEAAKTAQRADLQNH--LDTAQN 674
Query: 476 HIEELKRESEKTVRQ 490
+++ ++E K Q
Sbjct: 675 ALQDKQQELNKITTQ 689
Score = 71.2 bits (173), Expect = 2e-12
Identities = 89/425 (20%), Positives = 184/425 (43%), Gaps = 83/425 (19%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE 86
EL+ + ++++ + + L+ ++QEL + +QLD +V Q +EH
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD----QVTAKLQDKQEHC 704
Query: 87 KIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+ EYK++ L ++ L+ +KL+ + E + + + +D + +L +
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL-EVKASKEQALQDLQQQRQLNTDL 763
Query: 147 E---EFRQKSLDWEKQ-----RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
E K L+ EK+ RL Q++ +LE+ ++ L +Q E + Q++ KQ E+
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--EKQIL--KQDFET- 818
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
LS +++IQH E L R+ TV + Q+ K EK
Sbjct: 819 -LSQETKIQH-------------------EELNNRIQT------TVTELQKVKMEK---- 848
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATC 318
EAL E +K L + + ++ + EK +K KA ++ + TC
Sbjct: 849 ----EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA----------AILDLEKTC 894
Query: 319 KQLSQELMEKYE-----------ELKRMEAHNNEYKAEIKKLKEQILQGEQSY---SSAL 364
K+L +L + E L++ + +++ K E+ ++EQ++Q + +
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954
Query: 365 EGMKMEISHLTQELHQRDITIASTKG-------SSSDMEKRLRAEMQKAEDKAVEHKEIL 417
+ ++ I+ L Q Q+ I + +G +++E +L+ ++ +A + KE +
Sbjct: 955 QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 418 DQLES 422
L++
Sbjct: 1015 SVLQN 1019
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 87.0 bits (214), Expect = 3e-17
Identities = 80/360 (22%), Positives = 167/360 (46%), Gaps = 27/360 (7%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV---EEHEKIK- 89
K EWE + E + KIREQE K R + + KE M Q+ E+ EK++
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 90 -QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEE 148
+EM E ++++++L E++ ++ E+ +K+Q E + +E +++ R KI E
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 427
Query: 149 FRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL-ESVELSSQSEIQ 207
+K + EK+ +Q + Q K E+ Q ++ +++K+ E E+ Q E
Sbjct: 428 QEEKIREQEKKMW---RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKM 484
Query: 208 HLSSKLERANDTICANELEI---ERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEK 260
H K+ + + + E ++ E + + ++EQ++K EEK+RE E+
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEE 544
Query: 261 LLEAL------QEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESV 314
+++ QEEK + + ++ QE I E + + +EK++ + + +
Sbjct: 545 MMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ 604
Query: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
++ +++ E+ E++ E E + ++++ +E++ + E E M+ HL
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 78.6 bits (192), Expect = 1e-14
Identities = 83/352 (23%), Positives = 169/352 (48%), Gaps = 54/352 (15%)
Query: 24 ELQELMKQIDIMVAHKKS---EWEGRTHALETCLKIREQELK-----SLRSQLDVTHKEV 75
E +E M++++ M+ K+ E E + H E KIREQE K +R Q +E
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQE---KIREQEEKRQEEEKIREQEKRQEQEA 416
Query: 76 GMLHQQV---EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH 132
M Q+ E+ EKI+++ ++QE +K+HE+ EK+++++ R+
Sbjct: 417 KMWRQEEKIREQEEKIREQEKKMWRQE-EKIHEQ--------EKIREEEKRQ------EQ 461
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
E + E++ + E +RQK E++++ ++Q + Q + + +Q E I+ Q
Sbjct: 462 EEMWRQEEKIREQEEIWRQKEKMHEQEKI--RKQEEKVWRQEEKMHDQEEKIREQ----- 514
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
E + +I+ K+ + I E E + + +G +E+ Q++
Sbjct: 515 ---EEKMWRQEEKIREQEEKIREQEEKI----REQEEMMQEQEEKMGEQ----EEKMQEQ 563
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLE 312
EK+R E+ + +E+ RE K ++ QE I E Q+EK++E+ + Q E E
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWE---QEEKIREQEEMMQEQ---EEKMWE 617
Query: 313 SVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
C+Q +++ E+ E+++R E E + +++ +E++ + ++ +A+
Sbjct: 618 QEEKMCEQ-EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 73.6 bits (179), Expect = 4e-13
Identities = 90/454 (19%), Positives = 207/454 (45%), Gaps = 47/454 (10%)
Query: 56 IREQELKS----LRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILK 111
I ++ELK L+ +L + E + V+E ++ + + Q+ +L E L
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQ--QLQAEADHLG 271
Query: 112 RSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE 171
+ + + K + N +R ++ + E++ + E+ ++ WE++ Q+Q +
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE----WEEK---IQEQEEKIR 324
Query: 172 AQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLT 231
Q + + EQ E ++ Q +K E + + + K+ R + + E +I L
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 232 MRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKE 291
++++ ++ +++EEK +E EK+ E QE+++E +A + QE I E Q+E
Sbjct: 384 EKMHEQ--------EKIREQEEKRQEEEKIRE--QEKRQEQEAKMWRQEEKIRE---QEE 430
Query: 292 KLQEKVKATNTQ----HAVEAISLESVSATCKQL--SQELMEKYEELKRMEAHNNEYKAE 345
K++E+ K Q H E I E +++ +E + + EE+ R + +E + +
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE-K 489
Query: 346 IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE--- 402
I+K +E++ + E+ + + +I +++ +++ I + + E+++R +
Sbjct: 490 IRKQEEKVWRQEEK----MHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 403 MQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEE 462
MQ+ E+K E +E + + E ++ + + E K+ + + + E+E
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQE 605
Query: 463 EL------RSHHILERLDAHIEELKRESEKTVRQ 490
E+ + E++ E+++ + EK RQ
Sbjct: 606 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 639
Score = 70.1 bits (170), Expect = 4e-12
Identities = 101/479 (21%), Positives = 204/479 (42%), Gaps = 72/479 (15%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 161
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 280 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 318
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+ ++ QE I E R Q+E + EK + Q + E + ++L + + E
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM----RRLEEMMWE 374
Query: 328 KYEELKRME---------AHNNEYKAEIKKLKEQILQGEQS-----YSSALEGMKMEISH 373
K E+++ +E E + E +K++EQ + EQ + + +I
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLEN--RHLS 431
+++ +++ I + + +++ + EM + E+K E +EI Q E + + R
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 432 EMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
E V + E +H+ + R +EE++R EE RE E+ +R+
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWR--QEEKIREQ----------EEKIREQEEKIRE 541
Score = 69.7 bits (169), Expect = 6e-12
Identities = 75/306 (24%), Positives = 143/306 (46%), Gaps = 34/306 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 430
Query: 62 KSLRSQLDVTHKEVGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHEELCILK---RSYEK 116
K +R Q ++ +H+Q + E EK +++ M ++E + EE+ K EK
Sbjct: 431 K-IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 117 LQKKQMREFRGNTKNHRED---RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ 173
++K++ + +R K H ++ R + E++ + E+ R++ +Q ++Q ++ Q
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 174 RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMR 233
+ + EQ E +Q Q R+Q+ + E + +I+ K+ + I E +I
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIRE--QEEKIREQKEKIREQEEKIWEQEEKIRE---- 603
Query: 234 VNDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ 289
++QEQ++K EEK+ E E+ ++ +E+ R + + QE + R Q
Sbjct: 604 -------QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL---RQQ 653
Query: 290 KEKLQE 295
+EK+QE
Sbjct: 654 EEKMQE 659
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 87.0 bits (214), Expect = 3e-17
Identities = 104/482 (21%), Positives = 218/482 (45%), Gaps = 80/482 (16%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
ELQ+L +Q+ +KS+WEG+ ++LE+ L + + SL+S+L E+ + Q E
Sbjct: 1286 ELQDLQRQLS-QNQEEKSKWEGKQNSLESELMELHETMASLQSRL--RRAELQRMEAQGE 1342
Query: 84 EH--EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ K+ +T + + H + +++ + + E + R RS ++
Sbjct: 1343 RELLQAAKENLTAQVE------HLQAAVVEARAQASAAGILEE------DLRTARSALKL 1390
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
++E R+++ Q L Q+Q AQ KAL E ++ L R++++E++
Sbjct: 1391 KNEEVESERERA-----QAL--QEQGELKVAQGKALQENLALLTQTLAEREEEVETL--- 1440
Query: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR----- 256
+ +IQ L + E + L++++ V+ + QEQ Q+ EK R
Sbjct: 1441 -RGQIQELEKQREMQKAALELLSLDLKKRNQEVD--------LQQEQIQELEKCRSVLEH 1491
Query: 257 ------ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIS 310
E E+ L +E+ REL+ ++Q N++ ++ EK + +++ Q V+ +
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQ--VQDLK 1549
Query: 311 LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKME 370
+ V+ C L +E ++++ + + K +KE L+G++ E ++
Sbjct: 1550 KQLVTLECLALE------------LEENHHKMECQQKLIKE--LEGQR------ETQRVA 1589
Query: 371 ISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHL 430
++HLT +L +R + + D+E ++ +++ E K +Q+E L+ + HL
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649
Query: 431 SEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
++ + + + L L + LE++ R ILE +E++K + R+
Sbjct: 1650 TQDLERRDQEL--------MLQKERIQVLEDQRTRQTKILEE---DLEQIKLSLRERGRE 1698
Query: 491 FT 492
T
Sbjct: 1699 LT 1700
Score = 85.9 bits (211), Expect = 8e-17
Identities = 118/536 (22%), Positives = 224/536 (41%), Gaps = 85/536 (15%)
Query: 31 QIDIMVAHKKSE--WEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI 88
Q+D+ A K+ E WE TH LE L+ E+ L++ L +E + +++ E
Sbjct: 644 QVDLAEAEKRREALWEKNTH-LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702
Query: 89 KQEMTMEYKQ---ELKKLHEELCILKRSYEKL-QKKQMREFRGNT-KNHREDRSEIERLT 143
++ T + +Q E K+ E L + E L ++K E R + R+D +E +
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 144 AKIEEFRQKSL-DWEKQRLIYQQQVSSLEAQRKALAEQSEIIQA---------------- 186
+ +E + SL + ++Q + + LE Q + + + E+IQ
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 187 ---------QLVNRKQK----LESVELSSQSEIQHLSSKLERAND--------TICANEL 225
QL +Q+ LE + + + E+ L K E+ + + E
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLER 882
Query: 226 EIERLTMRVNDLVGTSMTVLQEQQQKE-------------EKLRESEKLLEALQEEKREL 272
E L MR+ + T M +Q Q+++E E +E LLE L + ++EL
Sbjct: 883 EKMELEMRLKEQQ-TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
Query: 273 KAALQSQENLIHEARIQKEKLQE--------------KVKATNTQHAVEAISLESVSATC 318
A Q E L + ++QK K QE ++K QH + +L+ S++
Sbjct: 942 ADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL 1001
Query: 319 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQEL 378
Q +L ++ E+LK ++ + +++ ++ L+ Q Y+ + ++ E + LT L
Sbjct: 1002 LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL 1061
Query: 379 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 438
+++ + + + S ++ L A Q ++ E KE+ Q+E L+ E + + E
Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Query: 439 LGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 494
L L + + E++LR+ L +A +L+ T Q AL
Sbjct: 1122 AQL---------LEELEASHITEQQLRAS--LWAQEAKAAQLQLRLRSTESQLEAL 1166
Score = 76.6 bits (187), Expect = 5e-14
Identities = 122/549 (22%), Positives = 233/549 (42%), Gaps = 85/549 (15%)
Query: 25 LQELMKQIDIMVAHKKSEWE---GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
LQE + + +A ++ E E G+ LE ++++ L+ L L ++EV + +Q
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
Query: 82 VEEHEKIK--------------QEMTMEYKQ--ELKKLHE-ELCILKRSYEKLQKK-QMR 123
++E EK + Q++T++ +Q EL+K E + +L+ +L+KK QM
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538
Query: 124 EF-RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA---- 178
E RG ++ ++ +E L ++EE K E Q+ + ++ E QR AL
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKM---ECQQKLIKELEGQRETQRVALTHLTL 1595
Query: 179 ---EQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVN 235
E+S+ +QAQ ++ LES E+Q +++ + I + + E LT +
Sbjct: 1596 DLEERSQELQAQS-SQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE 1654
Query: 236 D------LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ 289
L + VL++Q+ ++ K+ E + LE ++ RE L +Q L+ E R +
Sbjct: 1655 RRDQELMLQKERIQVLEDQRTRQTKILEED--LEQIKLSLRERGRELTTQRQLMQE-RAE 1711
Query: 290 KEKLQEKVKATNTQHAVEAISLESVSATCK------------QLSQELMEKYEELKRMEA 337
+ K K + + +H + + C+ QL Q+L + ++
Sbjct: 1712 EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL 1771
Query: 338 HNNEYKAEIKKLKEQILQG-------EQSYSSALEGMKMEISHLTQELHQRDITIASTKG 390
++ + EI L++Q+ + EQS S L+ + ++ QEL +G
Sbjct: 1772 LLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Query: 391 SSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSE-------MVMKLE----- 438
++++ A E + KE +L+ K + R L E V LE
Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGD 1891
Query: 439 ------------LGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 486
L L + + + TR L++ L++ +L+ D +E L+ ES+
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 487 TVRQFTALK 495
+ Q A +
Sbjct: 1952 SRHQEEAAR 1960
Score = 71.6 bits (174), Expect = 2e-12
Identities = 87/405 (21%), Positives = 182/405 (44%), Gaps = 36/405 (8%)
Query: 55 KIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSY 114
KI E++L+ ++ L +E+ Q ++E + + + + L E + ++ R
Sbjct: 1679 KILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL----EHMKLILRDK 1734
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL---- 170
EK + Q + + +++ L K+ E E++ ++ QQQ+
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
Query: 171 EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERL 230
E + ++L Q + Q L R Q+LE++ Q E Q + ER + A + +E+
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEAL----QQEQQQAQGQEERVKEKADALQGALEQA 1850
Query: 231 TMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK 290
M + + G ++ ++ EE+L + ++AL+E +L+A + QE +
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA----- 1905
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK--RMEAHNNEYKAEIKK 348
LQ++ +H VE +L+ + Q L E+ +EL+ R E+ ++ ++ E +
Sbjct: 1906 --LQQQCAEQAQEHEVETRALQD---SWLQAQAVLKERDQELEALRAESQSSRHQEEAAR 1960
Query: 349 LKEQILQGEQSYS-SALEGMK---MEISHLTQELHQRDITIAST----KGSSSDMEKRLR 400
+ + LQ + +AL+G + +E + L++ L T+ ++ + S +E+ LR
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020
Query: 401 AEMQKAEDKAVEHKEILDQLESLKL----ENRHLSEMVMKLELGL 441
+ + +D+ + ++E + QL+ E RH E LE L
Sbjct: 2021 IQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL 2065
Score = 70.1 bits (170), Expect = 4e-12
Identities = 94/434 (21%), Positives = 191/434 (44%), Gaps = 53/434 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L C+ + L +Q D +WE AL L+ E +L Q EV
Sbjct: 409 LAGCQEAVNLLQQQHD--------QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L ++ E +K ++E+ +Q+L+ L +E L+R +LQ Q +G + +E+
Sbjct: 461 LSKERELLQKAREEL----RQQLEVLEQEAWRLRRVNVELQL-QGDSAQGQKEEQQEELH 515
Query: 138 ----EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
E ERL + K + + + ++ + S + + L ++ + A L +Q
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 194 ---KLESVELSSQSEIQHLSS---KLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+L S E + ++E+ L + KL N+ + +++ + + +++ + + + ++
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 248 QQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENL-------IHEARIQKEKLQEK 296
+Q L+ E+EK EAL E+ L+A LQ E + + + +KE++Q+K
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 297 VKATNTQHAVEAISLESVSATCKQLSQEL---MEKYEELKRMEAHNNEYKAEIKKLKEQI 353
+ + Q LE + K+ + L +++ E L R +A +++ ++ +
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 354 LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH 413
+ Q SSA E ++ + E Q++ I TKG +L ++Q +
Sbjct: 756 AEQLQGLSSAKELLESSLF----EAQQQNSVIEVTKG-------QLEVQIQ----TVTQA 800
Query: 414 KEILD-QLESLKLE 426
KE++ ++ LKLE
Sbjct: 801 KEVIQGEVRCLKLE 814
Score = 67.4 bits (163), Expect = 3e-11
Identities = 105/514 (20%), Positives = 210/514 (40%), Gaps = 60/514 (11%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGML---HQ 80
EL +L Q D+ +K+E + R L L +++ + + + V +L H
Sbjct: 266 ELIQLKSQGDL----EKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHT 321
Query: 81 QVEEHEKIKQEMTMEYKQELKKLHEELC-ILKRSYEKLQKKQMRE--------------F 125
++ EHE E K L+++ +++ ++ + + + E +
Sbjct: 322 ELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDY 381
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
+ K RS + R +++ RQ+ ++ + QQQ E + KAL ++ +
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ--- 438
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSK---LERANDTICAN----ELEIERLTMRVN--- 235
+L + L + Q E+ LS + L++A + + E E RL RVN
Sbjct: 439 -KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRL-RRVNVEL 496
Query: 236 DLVGTSMTVLQEQQQKEEKL--RESEKLLE---ALQEEKRELKAALQSQENLIHEARIQK 290
L G S +E+QQ+E L RE E+L E L+ ++ E + L + + + ++
Sbjct: 497 QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEG 556
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
E L+++ A S+ +S++ L E+ + ++ A N + L
Sbjct: 557 ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLN 616
Query: 351 EQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS-DMEKRLRAEMQKAEDK 409
+Q+LQ E+ S +ME + + Q D+ A + + + L A++QKAE+
Sbjct: 617 QQLLQLEEENQSVCS--RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 410 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI 469
E + L ++ K E+ KL H+ + L + +EE+ + +
Sbjct: 675 GAELQADLRDIQEEK------EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
Query: 470 LER---------LDAHIEELKRESEKTVRQFTAL 494
E+ L+ ++ ++R+ + Q L
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Score = 67.0 bits (162), Expect = 4e-11
Identities = 120/548 (21%), Positives = 231/548 (42%), Gaps = 103/548 (18%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEG-RTHALETCLKIREQELKSLRSQLDVTHKEVG 76
+ + +A+ +E Q + + + E E R LET L+ ++EL QL+ +++
Sbjct: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT-QKELADASQQLERLRQDMK 956
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKK-----------LHEELCILKRSYEKLQK------ 119
+ + +E I Q E ++ELK+ L EE L + LQK
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 120 --------------KQMREFRGNTKNHREDRSEIER----LTAKIEEFRQKSLDWEKQRL 161
++++E T+ + + E+ER LT + E Q+ L ++
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 162 IYQQQVSSL-------EAQRKALAEQSEIIQAQLVNRKQKL--ESVELSSQSEIQHLSSK 212
I QQ++S+L + ++K L+ Q E+++ ++ ++ + +L + E H++ +
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQ 1136
Query: 213 LERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE--KLLEALQ---- 266
RA ++ A E + +L +R+ + EQQ + +++ L ALQ
Sbjct: 1137 QLRA--SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALG 1194
Query: 267 ---EEKRELKAALQSQENLIHEARIQKEKLQEKVKAT-NTQHAVEAISLESVSATCKQLS 322
E + EL S ++ E Q ++ + A+S E+V++ +L
Sbjct: 1195 SVCESRPELSGGGDSAPSV-----WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 323 QEL-------------MEKYEE-LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 368
Q+L ++K EE L EA ++ E++ L+ Q+ Q ++ S EG +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE-KSKWEGKQ 1308
Query: 369 MEISHLTQELHQRDITIASTKGSSSDMEKRL-RAEMQKAEDKAVEHKEILDQLESLKLEN 427
+ ELH+ T+AS ++ RL RAE+Q+ E + + E L+
Sbjct: 1309 NSLESELMELHE---TMAS-------LQSRLRRAELQRMEAQG--------ERELLQAAK 1350
Query: 428 RHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKT 487
+L+ V L+ + E S G + EE+LR+ +L E +RE +
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGIL------EEDLRTARSALKLKNEEVESERERAQA 1404
Query: 488 VRQFTALK 495
+++ LK
Sbjct: 1405 LQEQGELK 1412
Score = 51.2 bits (121), Expect = 2e-06
Identities = 92/427 (21%), Positives = 174/427 (40%), Gaps = 48/427 (11%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEH 85
Q L++Q ++ E T L+ L + + L L + E+ + +E
Sbjct: 1982 QHLLEQAEL-----SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036
Query: 86 EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAK 145
+ Q+ + +EL+ E +L++S + ++ M + + N RE+ EI L
Sbjct: 2037 VQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREE-EEIRGLHQS 2095
Query: 146 IEEFRQKSLDWEKQRLI---YQQQVSSLEA-----QRKALAEQSEIIQAQLVNRKQKLES 197
+ E Q +L ++Q ++ QQ ++LEA + + EQS KL+S
Sbjct: 2096 VREL-QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS-----------LKLDS 2143
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
+E Q E++ L + L + A E+E + DL L + + L+E
Sbjct: 2144 LEPRLQRELERLQAALRQTE----AREIEWRE---KAQDLA----LSLAQTKASVSSLQE 2192
Query: 258 SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT----QHAVEAISLES 313
L+A E+ + LQ + L A ++KE+L AT+T + + L
Sbjct: 2193 VAMFLQASVLERDSEQQRLQDELELTRRA-LEKERLHSP-GATSTAELGSRGEQGVQLGE 2250
Query: 314 VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISH 373
VS + S + MEK +R+E H + A ++ + ++ + S LE ++ E
Sbjct: 2251 VSGVEAEPSPDGMEKQSWRQRLE-HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRK 2309
Query: 374 LTQELHQR----DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRH 429
L +E + + I+ SS + + A+ A KE++ L LE +
Sbjct: 2310 LKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQ 2369
Query: 430 LSEMVMK 436
+ + +
Sbjct: 2370 KQDYITR 2376
Score = 50.1 bits (118), Expect = 5e-06
Identities = 76/401 (18%), Positives = 174/401 (43%), Gaps = 57/401 (14%)
Query: 18 LTSCEAELQELMKQIDIM---VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKE 74
L +C+A ++L + + I + + ++ L+ L R++EL+ + + + K
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
Query: 75 VGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHE-----ELCILKRSYEKLQKKQMREFRG 127
+ Q+ ++E + + QE E E++ LH+ +L + ++ E L+ ++ ++ R
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEE---EIRGLHQSVRELQLTLAQKEQEILELRETQQ-RN 2120
Query: 128 NTK----NHR----EDRS------------EIERLTAKIEEFRQKSLDWEKQRLIYQQQV 167
N + +H+ E++S E+ERL A + + + ++W ++ +
Sbjct: 2121 NLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSL 2180
Query: 168 SSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEI 227
+ +A +L E + +QA ++ R E L + E+ + + ER + + E+
Sbjct: 2181 AQTKASVSSLQEVAMFLQASVLERDS--EQQRLQDELELTRRALEKERLHSPGATSTAEL 2238
Query: 228 ---ERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
+++ ++ G + +K+ + E L +A+ + + ++ LQ +
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID-RSRLQRHNVQLR 2297
Query: 285 EARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQE------------LMEKYEEL 332
Q E+ + K+K A +A SLE AT +Q+ + E +E+
Sbjct: 2298 STLEQVERERRKLK-REAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV 2356
Query: 333 KRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISH 373
++A + E K+ ++ I + Q+ S L G+ +SH
Sbjct: 2357 VLLQA---QLTLERKQKQDYITRSAQT-SRELAGLHHSLSH 2393
Score = 38.1 bits (87), Expect = 0.019
Identities = 78/352 (22%), Positives = 135/352 (38%), Gaps = 63/352 (17%)
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
E+Q L QQQ++ +A + S+ Q + +KL++ L +S Q L +LE
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEAT 80
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKREL--KA 274
I +E + + L+E+QQ+ E L E L L EK ++ KA
Sbjct: 81 GGPIPQRWENVEEPNL------DELLVRLEEEQQRCESLAEVNTQLR-LHMEKADVVNKA 133
Query: 275 ALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR 334
+ E L + +++L K + L+ L +E++
Sbjct: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
Query: 335 MEAHNN----EYKAEIKKLKEQIL-----------QGEQSYSSALEG--------MKMEI 371
M++ + E KAE +L +L E + S ++G + +
Sbjct: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
Query: 372 SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLS 431
L +E H+R + K S D+EK AE+Q D+ E +L Q + +N
Sbjct: 254 QELEKEAHERSQELIQLK-SQGDLEK---AELQ---DRVTELSALLTQSQK---QNEDYE 303
Query: 432 EMVMKL------------ELGLHECSLPVSPLGSIATRFLEEEELRSHHILE 471
+M+ L EL HE SL +R +EE+L +++
Sbjct: 304 KMIKALRETVEILETNHTELMEHEASL---------SRNAQEEKLSLQQVIK 346
Score = 33.9 bits (76), Expect = 0.35
Identities = 67/353 (18%), Positives = 135/353 (38%), Gaps = 61/353 (17%)
Query: 103 LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR------QKSLD- 155
L E++ L++ + Q R+ + + + + + + +L AK+ ++R +K L+
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 156 --------WEK-QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
WE + + + LE +++ +E + QL +K + V + + ++
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAE-VNTQLRLHMEKADVVNKALREDV 138
Query: 207 QHLSSKLERANDTICANE-----------------------LEIERLTMRVNDLVGTSMT 243
+ L+ RA D + E L E +T R + L S T
Sbjct: 139 EKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198
Query: 244 VLQEQQQKEEKLRESEKLLE-----ALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+ K E +R S LL + + RE + + + + K QE K
Sbjct: 199 DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEK 258
Query: 299 ATNTQHAVEAISLESVSATCK-QLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE 357
+ + + E I L+S K +L + E L + + N +Y+ IK L+E + E
Sbjct: 259 EAH-ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317
Query: 358 QSYSSALE--------------GMKMEISHLTQELHQRDITIASTKGSSSDME 396
+++ +E ++ I +TQ + + IA G + +E
Sbjct: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370
Score = 31.6 bits (70), Expect = 1.7
Identities = 27/133 (20%), Positives = 60/133 (45%), Gaps = 6/133 (4%)
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
+++ + E V A +Q+++ + +LK + ++KL+ ++LQ Y S
Sbjct: 15 SLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQ----YRSWC 70
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
+ ++ + + QR + + + ++ RL E Q+ E A + ++ +E
Sbjct: 71 QELEKRLEATGGPIPQRWENV--EEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKAD 128
Query: 425 LENRHLSEMVMKL 437
+ N+ L E V KL
Sbjct: 129 VVNKALREDVEKL 141
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 86.7 bits (213), Expect = 5e-17
Identities = 127/476 (26%), Positives = 218/476 (45%), Gaps = 79/476 (16%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCK 319
+ L++E L ++L+ + + EAR++ + + K+
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI---------------------- 591
Query: 320 QLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQ--E 377
L + + E +L ++E + K E++ KE +GE++ E ++ E+ HL + E
Sbjct: 592 -LHESIKETSSKLSKIEFEKRQIKKELEHYKE---KGERA-----EELENELHHLEKENE 642
Query: 378 LHQRDIT---IASTKGSSSDME-KRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEM 433
L Q+ IT I K + + E L E +K + K + QLESL+ EN L E
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE- 701
Query: 434 VMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVR 489
LEL + SL + + +A LE +EL S E+L +E LK +KT R
Sbjct: 702 -ENLELRRNVESLKCASM-KMAQLQLENKELESEK--EQLKKGLELLKASFKKTER 753
Score = 84.3 bits (207), Expect = 2e-16
Identities = 96/448 (21%), Positives = 215/448 (47%), Gaps = 59/448 (13%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKS-LRSQLDVTHKEVGMLHQQV 82
+L++L +++ + +K+ ++ K+ E +L+S L+ L++ +++ L ++
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE--FRGNTKNHREDRS--- 137
EE + Y Q+L+ +EL +K++YE L+++Q E + + ED
Sbjct: 984 EE--------STNYNQQLR---QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E + T ++ + + + ++ E+ Q + +L+ Q K L Q+ +QAQ++ +++ S
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEI----ERLTMRVNDLVGTSMTVLQEQQQK-- 251
++ + +Q ++KL+ N T+ + + +L ++ + L + +V++E++
Sbjct: 1093 LQ-EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 252 --EEKLRESEKL----------LEALQEEKRELKAA----------LQSQENLIHEARIQ 289
+ +++ EKL E+L + LK+A L+ + N + + + Q
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
Query: 290 KEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 349
E L++ +K + +E + E+V+A K+L E ++ + + K L
Sbjct: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1271
Query: 350 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTK-GSSSDMEKRLRAEMQKAED 408
K +L + + LE E S L ++ Q DIT STK + ++ +L+ +++
Sbjct: 1272 KS-LLNNSKLEQTRLEA---EFSKLKEQYQQLDIT--STKLNNQCELLSQLKGNLEE--- 1322
Query: 409 KAVEHKEILDQLESLKLENRHLSEMVMK 436
E++ +LDQ+++L L+NR L E M+
Sbjct: 1323 ---ENRHLLDQIQTLMLQNRTLLEQNME 1347
Score = 77.4 bits (189), Expect = 3e-14
Identities = 111/488 (22%), Positives = 216/488 (44%), Gaps = 57/488 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E E Q L K+++I+ ++E +L+ C + + +K ++QL+ K + L +
Sbjct: 497 EKENQRLSKKVEIL----ENEIVQEKQSLQNCQNLSKDLMKE-KAQLE---KTIETLREN 548
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
E KI + QE + L++ + L++ + + ++++ K E E
Sbjct: 549 SERQIKILE-------QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 142 LTAKIE-EFRQ--KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+KIE E RQ K L+ K++ ++ LE + L +++E++Q ++ N K E +
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEK---GERAEELENELHHLEKENELLQKKITNLKITCEKI 658
Query: 199 ELSSQ--SEIQHLSSKLERANDTICA------------NELEIERLTMRVNDLVGTSMTV 244
E Q SE++ + KL++ D+ ++L+ E L +R N ++
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENL---IHEARIQKEKLQEKVKATN 301
Q Q E K ESEK E L++ LKA+ + E L I+ ++LQ+ ++ +N
Sbjct: 719 KMAQLQLENKELESEK--EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
Query: 302 TQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYS 361
+ LES + +Q L + EELK + + E K L+++ Q E+
Sbjct: 777 KKIQ----QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 362 SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE 421
++ E L Q+ +D T+ ++EK E + + +KE +L+
Sbjct: 833 Q----LEKENKRLRQQAEIKDTTLEENNVKIGNLEK----ENKTLSKEIGIYKESCVRLK 884
Query: 422 SLKLENRHLSEMVMKLELGLHECSLPVSPLGS--IATRFLEEEELRSHHILERLDAHIEE 479
L+ EN+ E+V + + + L S + T+ + + + H LE++ + E
Sbjct: 885 ELEKENK---ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941
Query: 480 LKRESEKT 487
L + + T
Sbjct: 942 LLHDEQST 949
Score = 68.6 bits (166), Expect = 1e-11
Identities = 110/483 (22%), Positives = 201/483 (41%), Gaps = 74/483 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEEL------CILKRSYEKLQKKQMREFRGN 128
L QQ E + +E ++ ++E K L +E+ C+ + EK K+ ++ +
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 129 TKNH---RED-----------RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR 174
K RED +++E+LT ++E+ + K+RL++ +Q S+ +++
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK-----IGLNKERLLHDEQ-STDDSRY 954
Query: 175 KALAEQSE-IIQAQLVNRKQKLESVEL---SSQSEIQHLSSKLE--RANDTICANELEIE 228
K L + E ++ L +++K+ ++E S + Q L +L+ + N + E
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Query: 229 RLTMRVNDLVGTSMTVLQEQQQK-EEKLRESEKLLEA------LQEEKRELKAALQSQE- 280
R+ + G +E Q+ E L+ ++L+E LQ EK+ LK L+ E
Sbjct: 1015 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1074
Query: 281 -NLIHEARI-----QKEKLQEKVKATNTQHA---VEAISLESVSATCKQLSQELMEKYEE 331
N +A+I Q LQE+ TQ+A VE +L S S + + +L+ +
Sbjct: 1075 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1134
Query: 332 LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI------------SHLTQELH 379
L+ + + ++K L + +++ + E E +H E+
Sbjct: 1135 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1194
Query: 380 QRDIT-----IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
RD+ + KG D+EK L+ E +K + H+ + + + L EN L+
Sbjct: 1195 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1254
Query: 435 MKL 437
+L
Sbjct: 1255 SQL 1257
Score = 64.7 bits (156), Expect = 2e-10
Identities = 92/424 (21%), Positives = 188/424 (44%), Gaps = 35/424 (8%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++ +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+ R ++ EL + E KLE +IE RV +L + +L
Sbjct: 300 SDA--RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 246 QEQQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ + E++L S+KL E L++E +LKA L E E + ++K++E ++
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDME---MERDMDRKKIEELME--- 410
Query: 302 TQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYS 361
E ++LE KQ E + EL+++ + +A K L ++ + S
Sbjct: 411 -----ENMTLEMAQ---KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV---NELTS 459
Query: 362 SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE 421
S L ++ME LT+ + + T+ S +G++S + K + + ++ + EI+ + +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 422 SLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELK 481
SL+ ++LS+ +MK + L + + + LE+E E L+ + L+
Sbjct: 520 SLQ-NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN-------EHLNQTVSSLR 571
Query: 482 RESE 485
+ S+
Sbjct: 572 QRSQ 575
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 17/251 (6%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQ-QVEEHEKIKQEMTMEYKQELKKLHEELCI 109
E+ +K RE +LKSL L H+++ +LH+ Q E+E + + LK H+ L +
Sbjct: 1140 ESVIKERE-DLKSLYDSLIKDHEKLELLHERQASEYESL-----ISKHGTLKSAHKNLEV 1193
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
R E + +++ +G ++ E ++E+ +E +++ E ++L +
Sbjct: 1194 EHRDLEDRYNQLLKQ-KGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--R 1249
Query: 170 LEAQRKALAEQSEIIQAQLVNRKQKLESVELSS---QSEIQHLSSKLERANDTICANELE 226
L L +++E++Q N K L + +L ++E L + ++ + T +
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1309
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
E L+ +L + +L + Q + ++ LLE E K + + ++E
Sbjct: 1310 CELLSQLKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
Query: 287 RIQKEKLQEKV 297
R QKEKL+EK+
Sbjct: 1367 RRQKEKLEEKI 1377
Score = 46.2 bits (108), Expect = 7e-05
Identities = 58/266 (21%), Positives = 115/266 (43%), Gaps = 21/266 (7%)
Query: 228 ERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEAR 287
+ L++ + D + QE ++K E+L + ++ LE ++ E + L+ Q NL+ +AR
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ---QENMNLLSDAR 303
Query: 288 IQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQEL---MEKYEELKRMEAHNNEYKA 344
++++ A + AV LES + K+ ++ + EELK +N+
Sbjct: 304 -SARMYRDELDALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELK----EDNQVLL 357
Query: 345 EIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDME-KRLRAEM 403
E K + E L+G ++ S L ++ E L +LH ++ DM+ K++ M
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM--------ERDMDRKKIEELM 409
Query: 404 QKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEE 463
++ + K+ +D+ L E +S E V+ L S LE E
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 464 LRSHHILERLDAHIEELKRESEKTVR 489
+E L ++ ++ + K ++
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILK 495
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 86.7 bits (213), Expect = 5e-17
Identities = 127/476 (26%), Positives = 218/476 (45%), Gaps = 79/476 (16%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCK 319
+ L++E L ++L+ + + EAR++ + + K+
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI---------------------- 591
Query: 320 QLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQ--E 377
L + + E +L ++E + K E++ KE +GE++ E ++ E+ HL + E
Sbjct: 592 -LHESIKETSSKLSKIEFEKRQIKKELEHYKE---KGERA-----EELENELHHLEKENE 642
Query: 378 LHQRDIT---IASTKGSSSDME-KRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEM 433
L Q+ IT I K + + E L E +K + K + QLESL+ EN L E
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE- 701
Query: 434 VMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVR 489
LEL + SL + + +A LE +EL S E+L +E LK +KT R
Sbjct: 702 -ENLELRRNVESLKCASM-KMAQLQLENKELESEK--EQLKKGLELLKASFKKTER 753
Score = 82.8 bits (203), Expect = 7e-16
Identities = 93/417 (22%), Positives = 201/417 (48%), Gaps = 59/417 (14%)
Query: 55 KIREQELKS-LRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRS 113
K+ E +L+S L+ L++ +++ L ++EE + Y Q+L+ +EL +K++
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEE--------STNYNQQLR---QELKTVKKN 1002
Query: 114 YEKLQKKQMRE--FRGNTKNHREDRS---EIERLTAKIEEFRQKSLDWEKQRLIYQQQVS 168
YE L+++Q E + + ED E + T ++ + + + ++ E+ Q +
Sbjct: 1003 YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1062
Query: 169 SLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEI- 227
+L+ Q K L Q+ +QAQ++ +++ S++ + +Q ++KL+ N T+ + +
Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQ-EQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 228 ---ERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEKL----------LEALQEEKR 270
+L ++ + L + +V++E++ + +++ EKL E+L +
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181
Query: 271 ELKAA----------LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQ 320
LK+A L+ + N + + + Q E L++ +K + +E + E+V+A K+
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1241
Query: 321 LSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQ 380
L E ++ + + K LK +L + + LE E S L ++ Q
Sbjct: 1242 LCGENDRLNHTYSQLLKETEVLQTDHKNLKS-LLNNSKLEQTRLEA---EFSKLKEQYQQ 1297
Query: 381 RDITIASTK-GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 436
DIT STK + ++ +L+ +++ E++ +LDQ+++L L+NR L E M+
Sbjct: 1298 LDIT--STKLNNQCELLSQLKGNLEE------ENRHLLDQIQTLMLQNRTLLEQNME 1346
Score = 68.6 bits (166), Expect = 1e-11
Identities = 110/483 (22%), Positives = 198/483 (40%), Gaps = 75/483 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEEL------CILKRSYEKLQKKQMREFRGN 128
L QQ E + +E ++ ++E K L +E+ C+ + EK K+ ++ +
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 129 TKNH---RED-----------RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS----- 169
K RED +++E+LT ++E+ + K+RL++ +Q +
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK-----IGLNKERLLHDEQSTDDRYKL 955
Query: 170 LEAQRKALAEQS-EIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIE 228
LE++ ++ ++S EI + ++ + +LE +Q Q L K + N + E
Sbjct: 956 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL--KTVKKNYEALKQRQDEE 1013
Query: 229 RLTMRVNDLVGTSMTVLQEQQQK-EEKLRESEKLLEA------LQEEKRELKAALQSQE- 280
R+ + G +E Q+ E L+ ++L+E LQ EK+ LK L+ E
Sbjct: 1014 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1073
Query: 281 -NLIHEARI-----QKEKLQEKVKATNTQHA---VEAISLESVSATCKQLSQELMEKYEE 331
N +A+I Q LQE+ TQ+A VE +L S S + + +L+ +
Sbjct: 1074 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1133
Query: 332 LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI------------SHLTQELH 379
L+ + + ++K L + +++ + E E +H E+
Sbjct: 1134 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 380 QRDIT-----IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
RD+ + KG D+EK L+ E +K + H+ + + + L EN L+
Sbjct: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1253
Query: 435 MKL 437
+L
Sbjct: 1254 SQL 1256
Score = 64.7 bits (156), Expect = 2e-10
Identities = 92/424 (21%), Positives = 188/424 (44%), Gaps = 35/424 (8%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++ +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+ R ++ EL + E KLE +IE RV +L + +L
Sbjct: 300 SDA--RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 246 QEQQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ + E++L S+KL E L++E +LKA L E E + ++K++E ++
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDME---MERDMDRKKIEELME--- 410
Query: 302 TQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYS 361
E ++LE KQ E + EL+++ + +A K L ++ + S
Sbjct: 411 -----ENMTLEMAQ---KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV---NELTS 459
Query: 362 SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE 421
S L ++ME LT+ + + T+ S +G++S + K + + ++ + EI+ + +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 422 SLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELK 481
SL+ ++LS+ +MK + L + + + LE+E E L+ + L+
Sbjct: 520 SLQ-NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN-------EHLNQTVSSLR 571
Query: 482 RESE 485
+ S+
Sbjct: 572 QRSQ 575
Score = 63.5 bits (153), Expect = 4e-10
Identities = 88/477 (18%), Positives = 201/477 (42%), Gaps = 61/477 (12%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E+E ++L K ++++ A K +T LE + + E + L+ L+ ++K++ L +
Sbjct: 731 ESEKEQLKKGLELLKASFK-----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ Q++ ME Q L+K EEL I + E+L+K+
Sbjct: 786 L-------QDLEME-NQTLQKNLEELKISSKRLEQLEKEN-------------------- 817
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
KSL+ E +L ++ LE + K L +Q+EI L K+ ++E
Sbjct: 818 ----------KSLEQETSQL--EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 202 SQS---EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
+++ EI R + N+ ++R T+ + LV ++ E+ + ++ +
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATC 318
EKL L++ + L +++ ++ + KL+ +K + + +LE+
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 319 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQEL 378
+Q+L ++ + +K+ N + ++ +E+++Q S + E T+EL
Sbjct: 986 TNYNQQLRQELKTVKK-----NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL 1040
Query: 379 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 438
+ + + +++ ++ +A + + ++ + Q+ +L+ + L E L+
Sbjct: 1041 LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100
Query: 439 LGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 495
+ + S L S +T + + +L L+ E+E +++ LK
Sbjct: 1101 TQNAKLQVENSTLNSQSTSLMNQN--------AQLLIQQSSLENENESVIKEREDLK 1149
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 17/251 (6%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQ-QVEEHEKIKQEMTMEYKQELKKLHEELCI 109
E+ +K RE +LKSL L H+++ +LH+ Q E+E + + LK H+ L +
Sbjct: 1139 ESVIKERE-DLKSLYDSLIKDHEKLELLHERQASEYESL-----ISKHGTLKSAHKNLEV 1192
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
R E + +++ +G ++ E ++E+ +E +++ E ++L +
Sbjct: 1193 EHRDLEDRYNQLLKQ-KGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--R 1248
Query: 170 LEAQRKALAEQSEIIQAQLVNRKQKLESVELSS---QSEIQHLSSKLERANDTICANELE 226
L L +++E++Q N K L + +L ++E L + ++ + T +
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1308
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
E L+ +L + +L + Q + ++ LLE E K + + ++E
Sbjct: 1309 CELLSQLKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
Query: 287 RIQKEKLQEKV 297
R QKEKL+EK+
Sbjct: 1366 RRQKEKLEEKI 1376
Score = 46.2 bits (108), Expect = 7e-05
Identities = 58/266 (21%), Positives = 115/266 (43%), Gaps = 21/266 (7%)
Query: 228 ERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEAR 287
+ L++ + D + QE ++K E+L + ++ LE ++ E + L+ Q NL+ +AR
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ---QENMNLLSDAR 303
Query: 288 IQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQEL---MEKYEELKRMEAHNNEYKA 344
++++ A + AV LES + K+ ++ + EELK +N+
Sbjct: 304 -SARMYRDELDALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELK----EDNQVLL 357
Query: 345 EIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDME-KRLRAEM 403
E K + E L+G ++ S L ++ E L +LH ++ DM+ K++ M
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM--------ERDMDRKKIEELM 409
Query: 404 QKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEE 463
++ + K+ +D+ L E +S E V+ L S LE E
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 464 LRSHHILERLDAHIEELKRESEKTVR 489
+E L ++ ++ + K ++
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILK 495
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 84.3 bits (207), Expect = 2e-16
Identities = 104/426 (24%), Positives = 193/426 (45%), Gaps = 45/426 (10%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
E +EL +Q + M ++ WE K+REQE K R + + +E M Q E
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEE-------KMREQEEKMWRQEERLWEQEKQMREQ--E 389
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK----KQMREFRGNTKNHREDRSEI 139
+ + ++E E + L++ E + ++ +E+++K K+M+E T++ E E
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE 449
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL------EAQRKALAEQSEII--QAQLVNR 191
ER+ + ++ R++ +Q Q+Q ++ E Q++ L EQ E + Q ++ +
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 192 KQKL--------ESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMT 243
++K+ + E+ Q + K+ D + E ++ ++ D
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 244 VLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQE-KVK 298
QEQ++K EEK+RE E++ E +++ RE + ++ QE + E Q+EK+QE + K
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMRER-EKKMREEEEMMREQEEKMQE---QEEKMQEQEEK 625
Query: 299 ATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
+ ++ + K QE EK E +R+ E E +K++EQ EQ
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQE--EKMWEQQRL-PEQKEKLWEHEKMQEQEKMQEQ 682
Query: 359 SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE---MQKAEDKAVEHKE 415
E KME QE D + S + EK++R E M++ E+K E +E
Sbjct: 683 E-EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 416 ILDQLE 421
+ + E
Sbjct: 742 KMQEQE 747
Score = 73.6 bits (179), Expect = 4e-13
Identities = 104/490 (21%), Positives = 227/490 (46%), Gaps = 50/490 (10%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL+E K+I ++ W E K+REQE K R + + +E + Q+
Sbjct: 278 EEELREQEKKIR---KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQE 334
Query: 82 VE---------EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL--QKKQMREFRGNTK 130
E + E+++++ ++QE K + E+ + R E+L Q+KQMRE +
Sbjct: 335 KELREQKELREQEEQMQEQEEKMWEQEEK-MREQEEKMWRQEERLWEQEKQMREQEQKMR 393
Query: 131 NHREDR-SEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQ-- 187
+ E + ERL K E R++ WE+ + +++ ++ Q K +Q E +Q +
Sbjct: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEK--KMQEQEKKTRDQEEKMQEEER 451
Query: 188 LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+ R++K+ E + + + + + + E + E + +RL + L +QE
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQE-EKEWQQQRLPEQKEKL--WEQEKMQE 508
Query: 248 QQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ-EKVKATNT 302
Q++K EEK+R+ E++ QE+K + ++ QE+ + E Q+EK++ ++ K +
Sbjct: 509 QEEKIWEQEEKIRDQEEMWG--QEKKMWRQEKMREQEDQMWE---QEEKMRDQEQKMWDQ 563
Query: 303 QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 362
+ +E + E T Q +E M + E ++ E E + +++ +E++ + E+
Sbjct: 564 EERMEKKTQEQEKKTWDQ--EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 363 ALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL--RAEMQKAEDKAVEHKEILDQL 420
E M + +++ +++ + + + E+++ + + + ++K EH+++ +Q
Sbjct: 622 QEEKMWEQ----EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 677
Query: 421 ESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 480
+ + E + + M+ + E + EEE +R E+ EE+
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKT------WDQEKMREEESMRER---EKKMREEEEM 728
Query: 481 KRESEKTVRQ 490
RE E+ +++
Sbjct: 729 MREQEEKMQE 738
Score = 67.4 bits (163), Expect = 3e-11
Identities = 82/393 (20%), Positives = 172/393 (43%), Gaps = 40/393 (10%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
E +E ++ + M +K W K+REQE + + + +E M Q+
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQE--------KMREQEDQMWEQEEKMRDQEQKMWDQEER 566
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
+K +++ + QE K EE R E+ +K+MRE + RE +++
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEE-----RMRER--EKKMRE---EEEMMREQEEKMQEQE 616
Query: 144 AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQ-LVNRKQKLESVELSS 202
K++E +K WE++ + +Q+ E + K ++ ++ + Q L +K+KL E
Sbjct: 617 EKMQEQEEKM--WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ 674
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL 262
+ E K++ + I E ++E+ T T QE+ ++EE +RE EK +
Sbjct: 675 EQE------KMQEQEEKIWEQE-KMEKKTQEQE-----KKTWDQEKMREEESMREREKKM 722
Query: 263 EALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLS 322
+E RE + +Q QE + E Q+E++ E+ + Q K
Sbjct: 723 REEEEMMREQEEKMQEQEEKMQE---QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 323 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 382
E M++ E++ E + + +++ +E++ E+ + G + ++ +++ ++
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK----MRGQEEKMWGQEEKMWGQE 835
Query: 383 ITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE 415
+ + E+++ +MQ E+K E +E
Sbjct: 836 EKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE 868
Score = 63.9 bits (154), Expect = 3e-10
Identities = 59/281 (20%), Positives = 131/281 (46%), Gaps = 34/281 (12%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEH 85
+++ +Q + M ++ WE K+ EQE K Q KE H++++E
Sbjct: 624 EKMWEQEEKMQEQEEKMWEQEE-------KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 86 EKIKQEMTMEYKQEL--KKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
EK++++ ++QE KK E+ K+++++ + ++ R K RE+ +
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQE---KKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 144 AKIEEFRQKSLD-----WEKQRLIYQQQVSSLEAQRKALAEQSEII--------QAQLVN 190
K++E +K + WE++ +++Q+ E QR L EQ E + Q ++
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR--LPEQKEKLWEHEKMQEQEKIWE 791
Query: 191 RKQKLESVELSSQSEIQHL---SSKLERANDTICANELEI----ERLTMRVNDLVGTSMT 243
+++K+ E + + + + K+ + + E ++ E++ + + G
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
+ ++ Q +EEK+RE E+ + +E+ RE + ++ QE I+
Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
Score = 63.5 bits (153), Expect = 4e-10
Identities = 80/406 (19%), Positives = 185/406 (45%), Gaps = 41/406 (10%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCIL 110
E L ++E + K R++ + + L +++ E+ +E + +++ +K+ + L
Sbjct: 243 EIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERL 302
Query: 111 KRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL 170
+ K+++++ + +R K RE E+ ++ E QK L +++++ Q+Q +
Sbjct: 303 REQEGKMREQEEKMWR-QEKRLREQEKELREQEKELRE--QKELREQEEQM--QEQEEKM 357
Query: 171 EAQRKALAEQSEII----------QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTI 220
Q + + EQ E + + Q+ ++QK+ E + + L K ER +
Sbjct: 358 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 417
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQ-QKEEKLRESEKLLEALQEEKRELKAALQSQ 279
E ++E++ T QE++ Q+EE++RE EK + +E RE + +Q Q
Sbjct: 418 KMWE-QVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Query: 280 ENLI---HEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRME 336
E + E Q+++L E+ + Q ++ + +++ E+ E+++ E
Sbjct: 477 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ------------EQEEKIWEQEEKIRDQE 524
Query: 337 AHNNEYKAEIKKL--KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSD 394
E + KK+ +E++ + E E M+ + + + + + + + D
Sbjct: 525 ----EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 395 MEKRLRAE--MQKAEDKAVEHKEIL-DQLESLKLENRHLSEMVMKL 437
E+++R E M++ E K E +E++ +Q E ++ + + E K+
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
Score = 56.6 bits (135), Expect = 5e-08
Identities = 59/289 (20%), Positives = 134/289 (46%), Gaps = 24/289 (8%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ--VE 83
+++ +Q + M ++ WE K++EQE K + + +E M QQ E
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEE-------KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT 143
+ EK+ + M+ ++++++ E++ ++ +K Q+++ + + E E E+
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKM 722
Query: 144 AKIEEF-RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII--QAQLVNRKQKL-ESVE 199
+ EE R++ ++Q Q+Q + Q + + EQ E + Q +L +K+KL E +
Sbjct: 723 REEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 782
Query: 200 LSSQSEIQHLSSKLERANDTICANELEI----ERLTMRVNDLVGTSMTVLQEQQ----QK 251
+ Q +I K+ + + E ++ E++ + + G + +++ Q+
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQE 842
Query: 252 EEKLRESEKLLEALQ---EEKRELKAALQSQENLIHEARIQKEKLQEKV 297
E+ + EK+ E +Q E+ RE + ++ QE + E + +EK+
Sbjct: 843 EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 56.2 bits (134), Expect = 7e-08
Identities = 78/377 (20%), Positives = 154/377 (40%), Gaps = 78/377 (20%)
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA-E 179
+ ++ G + E++R + + R K D + L ++ SLE R + E
Sbjct: 163 ESKDLAGRLHHSWHFAGELQRALSAVST-RHKKADRYIEELTKERDALSLELYRNTITNE 221
Query: 180 QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG 239
+ + A+L + ES + Q ++ L KLERA + +
Sbjct: 222 ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN------------- 268
Query: 240 TSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
T+ +E ++EE+LRE EK + +E+ + L+ QE + E Q+EK+ + K
Sbjct: 269 ---TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE---QEEKMWRQEK- 321
Query: 300 TNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQS 359
L E+ +EL+ E E K E+++ +EQ+ + E+
Sbjct: 322 ------------------------RLREQEKELREQEKELREQK-ELREQEEQMQEQEEK 356
Query: 360 YSSALEGMKMEISHL---TQELHQRDITIASTKGSSSDMEKRLRAE---MQKAEDKAVEH 413
E M+ + + + L +++ + + D E+R+ + +++ E++ E
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
Query: 414 KEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERL 473
+++ +Q+E ++ E + + E K TR EE+ I ER
Sbjct: 417 EKMWEQVEKMR-EEKKMQEQEKK-------------------TRDQEEKMQEEERIRER- 455
Query: 474 DAHIEELKRESEKTVRQ 490
E+ RE E+T+R+
Sbjct: 456 ----EKKMREEEETMRE 468
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 84.0 bits (206), Expect = 3e-16
Identities = 117/558 (20%), Positives = 231/558 (41%), Gaps = 95/558 (17%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSL---RSQLDVTHKEVG 76
+ EAEL L +++ V ++ EG + + E L+SL + Q+ +
Sbjct: 896 TAEAELSRLHREV-AQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANE 954
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELC-------------------ILKRSYEKL 117
L +Q+EE ++ ++ E KQ++++L +L + +R E L
Sbjct: 955 ALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEAL 1014
Query: 118 QKK--------QMREFRGNTKNHREDRSEIERLTAKIEEFRQKS--LDWEKQRLIYQQQV 167
K Q+R G++ + I+ L A+++ L+ E Q +I
Sbjct: 1015 AAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQ 1074
Query: 168 SSLEAQRKALAEQSEIIQAQLVNRK-QKLESVELSSQSEIQHLSSKLERANDTICA---- 222
E++ K L + E+ +++ +K ++LE E++H KL + A
Sbjct: 1075 ELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH 1134
Query: 223 NELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQE--------------- 267
N + L R DLV ++ V Q+KEE+ R+ + L++ALQ
Sbjct: 1135 NSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQ 1194
Query: 268 --------------------EKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVE 307
E E+K LQ++E+L+ + + + + LQ + + + A
Sbjct: 1195 VAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQF 1254
Query: 308 AISLESVSATCKQLSQELMEKY-------EELKRMEAHNNEYKAEIKKLKEQILQGEQSY 360
L A + L ++L E+ +E++ ++ ++ + EI+ LK+Q+ EQ
Sbjct: 1255 QAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQG 1314
Query: 361 SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 420
LEG++ + ++ EL ++ T+ + L+A++ + ++ K +L Q
Sbjct: 1315 RKELEGLQQLLQNVKSELEMAQEDLSMTQKD----KFMLQAKVSELKNNM---KTLLQQN 1367
Query: 421 ESLKLENRHLSEMVMKLELGLHECSLPVSPL--------GSIATRFLEEEELRSHHILER 472
+ LKL+ R + K G S P +P+ S+ L S L+
Sbjct: 1368 QQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKN 1427
Query: 473 LDAHIEELKRESEKTVRQ 490
L++ +++LK+E + RQ
Sbjct: 1428 LNSCLQQLKQEMDSLQRQ 1445
Score = 73.6 bits (179), Expect = 4e-13
Identities = 92/376 (24%), Positives = 172/376 (45%), Gaps = 27/376 (7%)
Query: 63 SLRSQLDVTH----KEVGMLHQQVE--EHEKIKQEMTMEYKQELKKLHEELCILKRSYEK 116
SL QL T KE G + Q++ E + + QE QE K + EE L+R E+
Sbjct: 619 SLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEE--DLQRRLEE 676
Query: 117 LQKKQMREFR-GNTKNHREDRSEIERLTA-----KIEEFRQKSLDWEKQRLIYQQQVSSL 170
+ ++ R R ++ E + E +LT ++E +Q+ LD KQ + Q+ + S
Sbjct: 677 FEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSR 736
Query: 171 EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERL 230
E AL + +QA+L + + S E + +Q+ LE A + + E++R
Sbjct: 737 EQSLDALQTHYDELQARLGELQGEAASRE-DTICLLQNEKIILEAALQAAKSGKEELDRG 795
Query: 231 TMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK 290
R+ + GT +E + EKLRE + E ++ AAL+ Q I E +Q+
Sbjct: 796 ARRLEE--GT-----EETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ 848
Query: 291 EKLQEKVK--ATNTQHAVEAISL--ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI 346
+ + E + AT+ + + + + + K+L QELM+ + E + EA + E+
Sbjct: 849 KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV 908
Query: 347 KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKA 406
++++ + E SA + +HL ++ +A T+ + + ++K++ Q+A
Sbjct: 909 AQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEA-LKKQIEELQQEA 967
Query: 407 EDKAVEHKEILDQLES 422
E K+ + +L S
Sbjct: 968 RKAITEQKQKMRRLGS 983
Score = 70.9 bits (172), Expect = 3e-12
Identities = 91/388 (23%), Positives = 167/388 (43%), Gaps = 38/388 (9%)
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW--EKQRLIYQQQVSSLEAQRKALA 178
Q +E G ++ R+ L + E +++ L EK RL Q + SLEA + AL
Sbjct: 375 QGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQ-ALK 433
Query: 179 EQSEIIQAQLVNRKQKLES-VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL 237
E++E+ QAQL KL++ VE S S Q L DT+ + ++ER + ++
Sbjct: 434 EKAEL-QAQLAALSTKLQAQVECSHSS--QQRQDSLSSEVDTLKQSCWDLERAMTDLQNM 490
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKV 297
+ L L+ +E+ + L + +++ ++ S++N +H+ R Q LQ ++
Sbjct: 491 LEAKNASL---ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQL 547
Query: 298 KATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE 357
+ + L++ A L Q + + Y++ A E + ++ I G+
Sbjct: 548 QQVQLERTTLTSKLKASQAEISSL-QSVRQWYQQ---QLALAQEARVRLQGEMAHIQVGQ 603
Query: 358 QSYSSALEGMKMEISHLTQEL--------HQRDITIASTKGSSSDMEKRLRAEMQKAEDK 409
+ + LE +K+E L+Q+L ++ A +G +DM + A MQ E K
Sbjct: 604 MTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAK 663
Query: 410 AVEHKEILDQLESLKLENRHLSEM---VMKLELGLHECSLPV------------SPLGSI 454
+ +++ +LE + E L M LE L + L + L +
Sbjct: 664 TMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLM 723
Query: 455 ATRFLEEEELRS-HHILERLDAHIEELK 481
L +E L+S L+ L H +EL+
Sbjct: 724 KQLTLTQEALQSREQSLDALQTHYDELQ 751
Score = 67.0 bits (162), Expect = 4e-11
Identities = 114/557 (20%), Positives = 240/557 (43%), Gaps = 100/557 (17%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIR---EQELKSLRSQLDVTHKEVGMLHQ 80
++QE ++ + + E+EG L+ EQ+L+ ++ L +++ L Q
Sbjct: 658 QIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQ 717
Query: 81 QVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRED----- 135
EH + +++T+ ++ L+ + L L+ Y++LQ + + E +G + RED
Sbjct: 718 ---EHLDLMKQLTLT-QEALQSREQSLDALQTHYDELQAR-LGELQGEAAS-REDTICLL 771
Query: 136 -----------------RSEIERLTAKIEEFRQKSLDW-EKQR---LIYQQQVSSLEAQR 174
+ E++R ++EE +++ + EK R I QV L+ +
Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQET 831
Query: 175 KALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
AL +Q + I+ Q + +K +E+ + S+ Q L S+L+ + + E+ + M+V
Sbjct: 832 AALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQ-LISELKATRKRLDSELKELRQELMQV 890
Query: 235 NDLVGTSMTVL----QEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK 290
+ T+ L +E Q + + + E L++ Q+E+ E++ LQS + K
Sbjct: 891 HGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQ-------FDK 943
Query: 291 EKLQEKVKATNT-QHAVEAISLESVSATCKQ------LSQELMEKYEELK-RMEAHNNEY 342
E++ +A + +E + E+ A +Q L +L +E+K + +A+ N
Sbjct: 944 EQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAV 1003
Query: 343 KAEIKKLKEQILQGEQSYSSALEGMKME--ISHLTQELHQR----DITIASTKGSSSDME 396
++L+E L +++ + L ++ + S + LH+R + + + S + +E
Sbjct: 1004 GILSRRLQEA-LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLE 1062
Query: 397 KRLRA-------EMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLEL---------- 439
K L+ E++++ +K +E ++ L + + + + L E KL L
Sbjct: 1063 KELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLT 1122
Query: 440 GLHECSLPVSPLGSIATRFL---------------------EEEELRSHHILERLDAHIE 478
GL + + + SI L EEE+ + H+++ L A +E
Sbjct: 1123 GLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
Query: 479 ELKRESEKTVRQFTALK 495
+ K + Q A K
Sbjct: 1183 KEKEKVNSLKEQVAAAK 1199
Score = 66.6 bits (161), Expect = 5e-11
Identities = 83/436 (19%), Positives = 192/436 (44%), Gaps = 70/436 (16%)
Query: 60 ELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK 119
ELK+ R +LD KE+ QV ++ + EL +LH E+ + +
Sbjct: 868 ELKATRKRLDSELKELRQELMQVHGEKRTAE-------AELSRLHREVAQV--------R 912
Query: 120 KQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ-RKALA 178
+ M + G+ ++ +++R E+E ++ +++ + + ++Q+ L+ + RKA+
Sbjct: 913 QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAIT 972
Query: 179 EQSEIIQ---AQLVNRKQKLESVELSSQSEIQHLSSKLERA------------------- 216
EQ + ++ + L + ++++++ + ++ + LS +L+ A
Sbjct: 973 EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGG 1032
Query: 217 --------NDTICANELEIERL----TMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEA 264
++ I A E E++ + T+ +L QE ++ EK+ E E L+
Sbjct: 1033 SSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE 1092
Query: 265 LQEEKRELKAALQSQENLIHEARIQKEKLQ---EKVKATNTQHAVEAISLESVSATCKQL 321
+ ++++K +S + L E +K KL + A +++ +L A QL
Sbjct: 1093 SRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Query: 322 SQE----LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA----------LEGM 367
+ + L K EE ++M+ +A ++K KE++ ++ ++A +
Sbjct: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
Query: 368 KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLEN 427
+E+S + +EL ++ + + + D++ R E + +++ A E+ + L+L
Sbjct: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIR---EGKHSQEIAQFQAELAEARAQLQLLQ 1269
Query: 428 RHLSEMVMKLELGLHE 443
+ L E + K +G E
Sbjct: 1270 KQLDEQLSKQPVGNQE 1285
Score = 62.0 bits (149), Expect = 1e-09
Identities = 75/328 (22%), Positives = 151/328 (46%), Gaps = 27/328 (8%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTH---ALETCLKIREQELKSLRSQLDVTHKE 74
L EA+L +L Q+ ++ K+ E H AL+ L+ ++++ SL+ Q+ E
Sbjct: 1142 LAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVE 1201
Query: 75 VGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ---KKQMREFRGNTKN 131
G H + H K E K+EL+ + L+ + LQ K +E
Sbjct: 1202 AG--HNR--RHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAE 1257
Query: 132 HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR 191
E R++++ L +++E K ++ + +V E + ++L +Q ++ + Q
Sbjct: 1258 LAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQ---G 1314
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
+++LE + Q +Q++ S+LE A + + + + L +V++L T+LQ+ QQ
Sbjct: 1315 RKELEGL----QQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL 1370
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISL 311
+ LR + +E K E ++ + I + + L+E ++ AV L
Sbjct: 1371 KLDLRRG--AAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLR---PPPAVSKEPL 1425
Query: 312 ESVSATCKQLSQELMEKYEELKR-MEAH 338
+++++ +QL QE+ + L+R ME H
Sbjct: 1426 KNLNSCLQQLKQEM----DSLQRQMEEH 1449
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 83.2 bits (204), Expect = 5e-16
Identities = 91/435 (20%), Positives = 198/435 (45%), Gaps = 45/435 (10%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV----------- 82
K EWE + E + KIREQE K R + + KE M Q+
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 83 ------EEHEKIK--QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
E+ EK++ +EM E ++++++L E++ ++ E+ +K+Q E + +E
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
+++ R KI E +K + EK+ +Q + Q K E+ Q ++ +++K
Sbjct: 428 QEAKMWRQEEKIREQEEKIREQEKK---MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 195 L-ESVELSSQSEIQH-LSSKLERANDTICANELEIERLTMRV---NDLVGTSMTVLQEQQ 249
+ E E+ Q E H K+ + + + E +I ++ + + ++EQ+
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544
Query: 250 Q---KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
+ +EEK+ E EK+ E +E+++E + + QE I E + + +EK++ +
Sbjct: 545 EMWREEEKMHEQEKIWE--EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEG 366
+ + ++ +++ E+ E+++ E E + ++ +E++ GEQ +
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKM--GEQEEKMCEQE 660
Query: 367 MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE---MQKAEDKAVEHKE-ILDQLES 422
KM+ T + +++ I + + E+++R + MQ+ E+K E +E + +Q E
Sbjct: 661 EKMQEQEET--MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 423 LKLENRHLSEMVMKL 437
++ + + K+
Sbjct: 719 MQEQEEKMRRQEEKM 733
Score = 72.8 bits (177), Expect = 7e-13
Identities = 79/367 (21%), Positives = 171/367 (46%), Gaps = 30/367 (8%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 444
Query: 62 KSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQEL----KKLHEELCILKRSYEKL 117
K +R Q K++ +++ E EKI++E + ++E+ +K+HE+ I ++ EK+
Sbjct: 445 K-IREQ----EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK-EKM 498
Query: 118 QKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKAL 177
+++ + + K R++ +I KI E +K W ++ I +Q+ E ++ +
Sbjct: 499 HEQEEKIRKQEEKVWRQEE-KIREQEEKIREQEEKM--WRQEEKIREQEEMWREEEK--M 553
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANE---LEIERLTMRV 234
EQ +I + + ++Q+ E + +I+ K+ R + I E E E +
Sbjct: 554 HEQEKIWEEE---KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 235 NDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQK 290
+ + +QEQ++K EEK+RE E++ + +E+ E + + QE + E
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 291 EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
+ +EK++ + + + ++ +++ E+ E++ E E + ++++ +
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 351 EQILQGE 357
E++ + E
Sbjct: 731 EKMWEQE 737
Score = 69.3 bits (168), Expect = 8e-12
Identities = 96/466 (20%), Positives = 203/466 (43%), Gaps = 72/466 (15%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 161
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 280 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 318
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELME 327
+ ++ QE I E R Q+E + EK + Q + E + ++ + + E
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM----RRQEEMMWE 374
Query: 328 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAS 387
K E+++R E E + +I++L+E++ + E+ + + E ++ +++ +
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 388 TKGSSSDMEKRLRAE---MQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEC 444
+ + E+++R + M + E+K E ++I ++ E R E + + E +HE
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE------EKRQEQEEMWRQEEKIHE- 487
Query: 445 SLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
+EE R E++ E+++++ EK RQ
Sbjct: 488 ---------------QEEIWRQK---EKMHEQEEKIRKQEEKVWRQ 515
Score = 54.7 bits (130), Expect = 2e-07
Identities = 65/288 (22%), Positives = 128/288 (44%), Gaps = 41/288 (14%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE-- 83
QE M + + + ++ W + E KIR+QE K R + + +E + Q+ +
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMW 534
Query: 84 -EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
+ EKI+++ M ++E K+HE+ I + EK Q+++ + +R K RE ++ R
Sbjct: 535 RQEEKIREQEEMWREEE--KMHEQEKIWEE--EKRQEQEDKMWRQEEKI-REQEEKVWRQ 589
Query: 143 TAKIEEFRQKSLDWE----KQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
KI E +K + E KQ ++Q ++ Q + + EQ E I+ Q +++ E +
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKM 649
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL---VGTSMTVLQEQQQK---- 251
+ ++ K++ +T+ E +I ++ + + ++QEQ++K
Sbjct: 650 G-EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708
Query: 252 --------------EEKLRESEKLLEALQEEKRELKAALQSQENLIHE 285
EEK+R E E+ E + L+ QE + E
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQE-------EKMWEQEVRLRQQEEKMQE 749
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 82.8 bits (203), Expect = 7e-16
Identities = 117/550 (21%), Positives = 211/550 (38%), Gaps = 126/550 (22%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
++L+ + Q+ + K +E +T LE L + EL R++ D +E G L Q+
Sbjct: 320 SDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQL 379
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT------KNHREDR 136
++ +L K +EL + K ++L + GN+ + ++R
Sbjct: 380 QK-----------LLADLHKREKELSLEKEQNKRLWDRDT----GNSITIDHLRRELDNR 424
Query: 137 S-EIERLTAKIEEFRQKSL-DWEKQRLIYQ------QQVSSLEAQRKALAEQSEIIQAQL 188
+ E++RL A ++ + + E+Q Q ++VSSL AQ ++ E + +L
Sbjct: 425 NMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEEL 484
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
+K LES S+ I L++ L+ I A EI +L RV+ + LQ
Sbjct: 485 TAKKMTLES----SERTISDLTTSLQEKERAIEATNAEITKLRSRVD----LKLQELQHL 536
Query: 249 QQKEEKLR--------------ESEKLLE---------------------ALQEEKRELK 273
+ + + LR E +K++E A+Q EK +L+
Sbjct: 537 KNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE 596
Query: 274 AALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSAT---------CKQLSQE 324
+ + + E +I K+K K++ + V + LE V K + QE
Sbjct: 597 KEINDRRMELKELKILKDKKDAKIRELEAR--VSDLELEKVKLVNAGSERLRAVKDIKQE 654
Query: 325 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 384
+ E+K + N E + LK + +KM++ EL Q T
Sbjct: 655 RDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNT 714
Query: 385 IASTKGS-------SSDMEKRLRAE----------------------------------- 402
+ S +GS + M+K++ A+
Sbjct: 715 LKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKL 774
Query: 403 MQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEE 462
Q+ A E ++ +LE L+ + R L E V +E+ L + SL + I R +E
Sbjct: 775 SQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQES 834
Query: 463 -ELRSHHILE 471
L+ H L+
Sbjct: 835 VRLKLQHTLD 844
Score = 70.1 bits (170), Expect = 4e-12
Identities = 90/473 (19%), Positives = 192/473 (40%), Gaps = 53/473 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
EA E +I++++ + E E + ++ S RSQ + ++ ++ +Q
Sbjct: 248 EALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQ 307
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYE-KLQKKQMREFRGNTKNHREDRSEIE 140
+ + + + +L EL KR YE K ++ + + N SE+
Sbjct: 308 ARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLAN--------SELT 359
Query: 141 RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVEL 200
+ ++F Q+S + + Q Q+ ++ L + K L+ + E + ++L +
Sbjct: 360 EARTERDQFSQESGNLDDQ---LQKLLADLHKREKELSLEKE--------QNKRLWDRDT 408
Query: 201 SSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK------ 254
+ I HL +L+ N + E ++ L + M +Q + + EK
Sbjct: 409 GNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTA 468
Query: 255 -LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLES 313
L ++++L + EE K L+S E I + ++ + ++ATN +
Sbjct: 469 QLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAE---------- 518
Query: 314 VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISH 373
++ ++ +L E + LK H + E + LK Q+ + ++ +E ++ +I +
Sbjct: 519 ITKLRSRVDLKLQE-LQHLKNEGDHLRNVQTECEALKLQMTEKDK----VIEILRQQIEN 573
Query: 374 LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEM 433
+TQ + Q T + + + +EK + D+ +E KE+ + + R L
Sbjct: 574 MTQLVGQHGRTAGAMQVEKAQLEKEI-------NDRRMELKELKILKDKKDAKIRELEAR 626
Query: 434 VMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 486
V LEL + + GS R +++ + +L + EL SE+
Sbjct: 627 VSDLELE----KVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEE 675
Score = 55.5 bits (132), Expect = 1e-07
Identities = 66/367 (17%), Positives = 161/367 (43%), Gaps = 48/367 (13%)
Query: 18 LTSCEAELQELMKQIDIMVA---HKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKE 74
+ + AE+ +L ++D+ + H K+E + L+ + E ++L+ Q+ K
Sbjct: 512 IEATNAEITKLRSRVDLKLQELQHLKNEGDH--------LRNVQTECEALKLQMTEKDKV 563
Query: 75 VGMLHQQVE-------EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
+ +L QQ+E +H + M +E Q K++++ LK KK +
Sbjct: 564 IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIREL 623
Query: 128 NTKNHREDRSEIERLTAKIEEFRQ-KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQA 186
+ + +++ + A E R K + E+ +L+ + + S E L+E+ E+++
Sbjct: 624 EARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNN--LSEEYEVLKR 681
Query: 187 QLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQ 246
N+ +++E + +++ S+LE+ +T+ + E G+ ++
Sbjct: 682 NFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSME--------------GSDGHAMK 727
Query: 247 EQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV 306
++++ ++ALQ + + L+ A+ + H + +K KL +++ T+
Sbjct: 728 VAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNK 787
Query: 307 EAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEG 366
A LE + + ++L E++ ME ++ + + ++ I + EQ E
Sbjct: 788 MAGELEVLRSQERRLK-------EKVTNMEVALDKASLQFAECQDIIQRQEQ------ES 834
Query: 367 MKMEISH 373
+++++ H
Sbjct: 835 VRLKLQH 841
Score = 35.8 bits (81), Expect = 0.092
Identities = 67/319 (21%), Positives = 126/319 (39%), Gaps = 48/319 (15%)
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
K+ E V +++ L +L +N+ +E + L V DL T LQE Q +
Sbjct: 73 KEHFERVLEEYSHQVKDLQRRLNESNEL---HEKQKFYLRQSVIDL----QTKLQEMQME 125
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQ-------- 303
+ + + + QE+ R +N +HE K ++ +K +NTQ
Sbjct: 126 RDAMADIRRRESQSQEDLRN------QLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMM 179
Query: 304 --HAVEAISLESVSATCKQLSQELMEKYEELKRMEAHN---------NEYKAEIKKLKEQ 352
H + S+ ++ S + + +++ + + + E EI LK +
Sbjct: 180 LSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGR 239
Query: 353 ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE 412
I E + + +I L Q+ HQ I + S+ E + +KA +
Sbjct: 240 IFPVEDQLEALKSESQNKIELLLQQ-HQDRI-----EQLISEHEVEITGLTEKASSARSQ 293
Query: 413 HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGS---IATRFLEE--EELRSH 467
I Q+E ++ + R+ + M M+ L + VS L S A R E+ EEL
Sbjct: 294 ANSIQSQMEIIQEQARNQNSMYMR---QLSDLESTVSQLRSELREAKRMYEDKTEELEKQ 350
Query: 468 HILERLDAHIEELKRESEK 486
+L ++ + E + E ++
Sbjct: 351 LVL--ANSELTEARTERDQ 367
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 82.8 bits (203), Expect = 7e-16
Identities = 111/520 (21%), Positives = 220/520 (42%), Gaps = 73/520 (14%)
Query: 22 EAELQELMKQIDIMVA-HKKSEWEGRTHALETC---LKIREQELKSLRSQLDVTHKEVGM 77
E ++ E +++ I+ A + K+E E +E LK+ E +L +LRS+ + K++
Sbjct: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
Query: 78 LHQQVEEHEKI----------KQEMTMEYKQE-----------LKKLHEELCILKRSYEK 116
Q+ E +K+ K++ ++ K+E LK+L+E + L E
Sbjct: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE- 2280
Query: 117 LQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKA 176
+ K + + + R+ IE+L A++E EK++L QQ+ E
Sbjct: 2281 IMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD-------EKKQLCVLQQLKESEHHADL 2333
Query: 177 LAEQSEIIQAQLVNRKQKLESVEL---SSQSEIQHLSSKLE----------------RAN 217
L + E ++ +L + E L +S+ E++ L +K+E R+
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393
Query: 218 DTICANELEIERLTMRVNDLVGTSM-TVLQEQQQKEEKLRE-SEKLLEALQEEKRELKAA 275
NEL+ E+ + +++ +S +LQE++Q++ +++E S +E LQ + +EL
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER 2453
Query: 276 LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRM 335
+ + N + +++ L +V+ + A L+ L + +E++
Sbjct: 2454 VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG 2513
Query: 336 EAHNNEYKAEIKKLKEQILQGEQSYS--SALEG-------MKMEISHLTQELHQRDITIA 386
+ + EI +LK QI EQ S S +EG +E+ +LT EL Q+ +
Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 387 STKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSL 446
S S D + L++ +K + ++LE K++ E V K+ E
Sbjct: 2574 SKNASLQDTLEVLQS----------SYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623
Query: 447 PVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 486
+ + EE + + L +EE+K ++
Sbjct: 2624 EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Score = 80.9 bits (198), Expect = 2e-15
Identities = 93/447 (20%), Positives = 211/447 (47%), Gaps = 40/447 (8%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE------QELKSLRSQLDVTHK 73
+C+A+ Q L Q++ + K +G A + ++ QE++ + +L+ +
Sbjct: 2463 ACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDE 2522
Query: 74 EVGMLHQQVEEHEKIKQEMT-MEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH 132
E+ L Q+++ E++ +++ +E + +L K + L + + E QK Q+ + + +
Sbjct: 2523 EISRLKNQIQDQEQLVSKLSQVEGEHQLWK-EQNLELRNLTVELEQKIQVLQSKNASLQD 2581
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
T ++ + K+L+ E + L ++S +E K A+++E+ Q ++
Sbjct: 2582 ----------TLEVLQSSYKNLENELE-LTKMDKMSFVEKVNKMTAKETEL-QREMHEMA 2629
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
QK ++ E L+ +L+ + I +++ +++ LT+ ++L + + ++Q +KE
Sbjct: 2630 QKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKE 2689
Query: 253 EKLRE--SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIS 310
K+RE +E L + EK+ L + + E + +EKL K + ++Q +
Sbjct: 2690 GKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQK----LE 2745
Query: 311 LESVSATCKQLSQELM---EKYEELKRMEAHNNEYKAEIKKLKEQ-------ILQGEQSY 360
++ + ++ ++L+ L + EELK+ + N +Y ++KK E+ +++ +
Sbjct: 2746 IDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQL 2805
Query: 361 SSALEGMKMEISHL-TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 419
E ++ E+S L + Q+ T+ TK ++ ++ + E+K E E LD+
Sbjct: 2806 EEEKEILQKELSQLQAAQEKQKTGTVMDTK--VDELTTEIKELKETLEEKTKEADEYLDK 2863
Query: 420 LESLKLENRHLSEMVMKLELGL-HECS 445
SL + + L + LE + H CS
Sbjct: 2864 YCSLLISHEKLEKAKEMLETQVAHLCS 2890
Score = 78.2 bits (191), Expect = 2e-14
Identities = 103/437 (23%), Positives = 198/437 (45%), Gaps = 42/437 (9%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVE--EHEKIKQEMTMEYKQE-LKKLHEELCILKRSY 114
E EL +RS+ E L +E + EK+ E E KQ+ + L EEL ++
Sbjct: 1901 ENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVT--- 1957
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR 174
+ + RG + + +++L+ K++E Q+ L+ + ++ QV+ E +
Sbjct: 1958 -----SERNQLRGELDTMSKKTTALDQLSEKMKEKTQE-LESHQSECLHCIQVAEAEVK- 2010
Query: 175 KALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
E++E++Q L + +L + Q ++Q L + + T C E +I +L
Sbjct: 2011 ----EKTELLQT-LSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065
Query: 235 NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
LV S ++ + + + K LEA EK E L S + +H+ R EKL+
Sbjct: 2066 ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 295 EKVKATNTQ--HAVEAI-----SLESVSATCKQLSQELM--EKYEELKRMEAHNNEYKAE 345
+++A + H E + +S+ + L +EL E+ +EL ++A N+ KAE
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENS--KAE 2183
Query: 346 IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 405
++ LK QI + + +L+ ++++ L E I +G S+++K L +
Sbjct: 2184 VETLKTQI----EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL 2239
Query: 406 AEDKAVEHKEILDQ----LESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEE 461
E+K +I ++ +E L+ + + L+E V L + + + S+ EE
Sbjct: 2240 LEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL---CGDQEIMKATEQSLDPPIEEE 2296
Query: 462 EELRSHHILERLDAHIE 478
+LR+ +E+L A +E
Sbjct: 2297 HQLRNS--IEKLRARLE 2311
Score = 76.3 bits (186), Expect = 6e-14
Identities = 104/485 (21%), Positives = 216/485 (44%), Gaps = 60/485 (12%)
Query: 24 ELQELMKQIDIMVAHKK-----SEWEGRTHALETCLKIREQELKSLRSQLDVTHKE---- 74
+LQE + Q + + +K ++ E + + LK RE ++ L +L T KE
Sbjct: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 75 VGMLHQQVEEHEKIKQEMTME--YKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH 132
+ L + +E+E++K+E T+ +K E +KL L ++ E LQ K NH
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKL---LTQMESEKENLQSKI---------NH 646
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
E + +++ + R ++L+ +++ L ++ +L + + + E + + +
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENL--SVEIRNLHNVLDSKSVEVETQKLAYMELQ 704
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
QK E + Q EI+++ K + + E +++ L+ + D + E +
Sbjct: 705 QKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLR 764
Query: 253 EKLRESEKLLEALQEEKRELKAALQ------SQENLIHE-ARIQKEKLQEKVKATNT--- 302
+ L+ + L ++ +R L A Q S N+I E + E+ + +++A +
Sbjct: 765 DLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN 824
Query: 303 ----QHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 358
Q+ V+ SLE + KQ++ +L ++ EEL +++ +++E +++ EQ
Sbjct: 825 SAILQNRVD--SLEFSLESQKQMNSDLQKQCEELVQIKG----------EIEENLMKAEQ 872
Query: 359 SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 418
+ S + IS L ++ +A T + + EK L+ K E + E
Sbjct: 873 MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE------ 926
Query: 419 QLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEE-EEL-RSHHILERLDAH 476
++ LK N L + + +L+L SL + SI + E EEL + + L+ ++A
Sbjct: 927 -IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985
Query: 477 IEELK 481
+ + K
Sbjct: 986 LNQEK 990
Score = 72.0 bits (175), Expect = 1e-12
Identities = 82/406 (20%), Positives = 189/406 (46%), Gaps = 32/406 (7%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
LE L + E LR +LD K+ L Q E+ ++ QE+ + L +
Sbjct: 1949 LEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAE 2008
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
+K E LQ + +D++ ++ +E+ Q +L K L + Q++
Sbjct: 2009 VKEKTELLQ-----TLSSDVSELLKDKTHLQEKLQSLEKDSQ-ALSLTKCEL--ENQIAQ 2060
Query: 170 LEAQRKALAEQSEIIQAQL-------VNRKQKLESVELSSQSEIQHLSSKLERANDTICA 222
L +++ L ++SE +QA+L +N + LE+ + LSS E +
Sbjct: 2061 LNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL--- 2117
Query: 223 NELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENL 282
IE+L +R+ + + ++ +++E RE++ L + ++ +REL+ + ++QE +
Sbjct: 2118 -RRGIEKLRVRIEADEKKQLHIAEKLKERE---RENDSLKDKVENLERELQMSEENQELV 2173
Query: 283 IHEARIQK---EKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHN 339
I +A K E L+ +++ V + L ++ + + L++++ EK +L ++
Sbjct: 2174 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLL 2233
Query: 340 NEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQEL----HQRDITIASTKGSSSDM 395
+ +K+ +++ ++ +Q ++ +A+E ++ ++ L + + ++I A+ + +
Sbjct: 2234 SSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI 2293
Query: 396 EK--RLRAEMQKAEDK-AVEHKEILDQLESLKLENRHLSEMVMKLE 438
E+ +LR ++K + + K+ L L+ LK H + ++E
Sbjct: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339
Score = 67.4 bits (163), Expect = 3e-11
Identities = 95/463 (20%), Positives = 187/463 (40%), Gaps = 90/463 (19%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L C EL Q D + K + E + L L + Q +S R L+
Sbjct: 336 LNKCRDELVRTTAQYD-QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE-------- 386
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
Q+++E EK E+++EL + L + +++ + +E + H ++
Sbjct: 387 --QKIKEKEK-------EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 138 EIERLTA-------KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII------ 184
E+++LT+ +EEF+QK E+ Q + + L + + +++ ++
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Query: 185 --------QAQLVNRKQKL-------ESVELSSQSEIQHLSSKLERANDTICANELEIER 229
+A+L N KQ L E ++ + S+ L E+ N N L +E+
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ--ENSLTLEK 555
Query: 230 LTMRVNDLV---GTSMTVLQEQQQKEEKL--------RESEKLLEALQEEKRELKAALQS 278
L + V DL S +L++++ E+L +ES+ LL AL+ +K+E + +
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
Query: 279 Q----------ENLIHEARIQKEKLQEKVKATNTQHAVEAIS-------LESVSATCKQL 321
+ E L+ + +KE LQ K+ T + I + ++ + L
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 322 SQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR 381
S E+ + L K +L+++ +Q + +E M ++ S LT
Sbjct: 676 SVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLT------ 729
Query: 382 DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
G D+E +L+ + DK ++++ + ESL+
Sbjct: 730 --------GQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLR 764
Score = 65.9 bits (159), Expect = 8e-11
Identities = 92/452 (20%), Positives = 204/452 (45%), Gaps = 47/452 (10%)
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEM-----TMEYKQELKKLHEELCILKRSYE 115
++ LR++L+ K+ + QQ++E E + +E + E+ + ++E L+
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2362
Query: 116 KLQKKQMR-EFRGNTKNHR-------EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQV 167
K + + ++ + G T++ R RSE E LT ++++ +++ + E ++ +
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422
Query: 168 SSLEAQRKALAEQS----EIIQAQLVNRKQKLESV---ELSSQSEIQHLSSKLERANDTI 220
E ++ + E+S E++Q QL +++ ++ + + +++ Q+LSS++E
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE------ 2476
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
ELE +L +++ + + +++ + ++ LE EE LK +Q QE
Sbjct: 2477 -CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQE 2535
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK-RMEAHN 339
L+ + +V+ + + + L +++ +Q Q L K L+ +E
Sbjct: 2536 QLVSKL--------SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQ 2587
Query: 340 NEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL 399
+ YK ++ E + S+ + M + + L +E+H+ A + S + RL
Sbjct: 2588 SSYK-NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRL 2646
Query: 400 RAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFL 459
E+Q + E K DQL+ L LEN SE+ L+ +H+ V G + +
Sbjct: 2647 AGELQLLLE---EIKSSKDQLKELTLEN---SELKKSLDC-MHKDQ--VEKEGKVREE-I 2696
Query: 460 EEEELRSHHILERLDAHIEELKRESEKTVRQF 491
E +LR H ++ A + + ++ E ++ +
Sbjct: 2697 AEYQLRLHEAEKKHQALLLDTNKQYEVEIQTY 2728
Score = 62.0 bits (149), Expect = 1e-09
Identities = 109/504 (21%), Positives = 211/504 (41%), Gaps = 68/504 (13%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L + E++E + + + M +E R L+ + + S L+ KE+ +
Sbjct: 856 LVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915
Query: 78 LHQQVEEHEKIKQEMTM------EYKQELKKLHEELCILKR---SYEKLQKKQMREFRGN 128
L+ +VE + QE+ + +EL+ L E L + K+ S L K+++ E
Sbjct: 916 LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQE 975
Query: 129 TKNHREDRSEIER----LTAKIEEF------RQKSLD-----WEKQRLIYQQQVSS---- 169
+E + + + L K E F R+KS+ +++++LI Q+
Sbjct: 976 NGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNA 1035
Query: 170 ---LEAQRKALAEQSEIIQAQL-------VNRKQKLESVELSSQSEIQHLSSKLERANDT 219
L + KA E++ ++ L NRK +LE ++ + E Q +KL A +
Sbjct: 1036 YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER 1095
Query: 220 ICANELEIE--------RLTMRVNDLVGTSMTVLQE-QQQKEEKLRESEKLLEALQEEKR 270
LE+E +T N+ + + QE KEE+ + +++ + LQE ++
Sbjct: 1096 NQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQ 1155
Query: 271 ELKAALQSQENLIHEARIQKEKLQEKVKATNTQH-------AVEAISLESVSATCKQLSQ 323
+K E E+ + ++E+ N + V+ ISL+S +A QL
Sbjct: 1156 LMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL-- 1213
Query: 324 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQ---ELHQ 380
E M + +ELK E +E + E + + Q ++G+ S+ + EIS L + +
Sbjct: 1214 EAMLRNKELKLQE---SEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
Query: 381 RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELG 440
+ I+ +S + L+ +Q +K E ++I + L++ K E+V +L
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKY------ELVTELNDS 1324
Query: 441 LHECSLPVSPLGSIATRFLEEEEL 464
EC + + L E ++
Sbjct: 1325 RSECITATRKMAEEVGKLLNEVKI 1348
Score = 61.6 bits (148), Expect = 2e-09
Identities = 105/535 (19%), Positives = 217/535 (40%), Gaps = 89/535 (16%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALET---CLKIREQELKSLRSQLDVTHKEVG 76
S E E Q+L M +K+E+ + H E CLK + L Q++ ++
Sbjct: 690 SVEVETQKLA----YMELQQKAEFSDQKHQKEIENMCLKTSQ-----LTGQVEDLEHKLQ 740
Query: 77 MLHQQVEEHEKIKQEMTMEYK--QELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
+L ++ + ++ Q++ EY+ ++L K + + +++ + F H
Sbjct: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQR----SLLAFDQQPAMHHS 796
Query: 135 DRSEIER---LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQ---L 188
+ I + ++ E R ++ K I Q +V SLE ++ + + +Q Q L
Sbjct: 797 FANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEEL 856
Query: 189 VNRKQKLES----VELSSQSEIQHLSSKLERANDTICANELEI----------ERLTMRV 234
V K ++E E QS + S ++ + + A++ + E+ +
Sbjct: 857 VQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 916
Query: 235 NDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHE----- 285
ND V T +QE ++ E+ L+E + L E L EK+E+ + + + I E
Sbjct: 917 NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
Query: 286 -------ARIQKEKL----------------QEKVKATNTQHAVEAISL----ESVSATC 318
A + +EK+ ++ + + Q+ E + L E
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 319 KQLSQELMEKYEELKRMEAHNNE-------YKAEIKKLKEQILQGEQSYSSALEGMKMEI 371
+ LSQ+ E+ ++E NE K E+++LKE + Q + + L +
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERN 1096
Query: 372 SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLS 431
+L EL + + + +D + ++E + + + KE ++++ + +
Sbjct: 1097 QNLMLEL---ETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
Query: 432 EMVMKLELGLHEC-SLPVSPL-GSIATRFLEEEELRSHHILERLDAHIEELKRES 484
E +MK+ HEC +L P+ S+ R E E + ++D ++E+ +S
Sbjct: 1154 EQLMKVMKTKHECQNLESEPIRNSVKER---ESERNQCNFKPQMDLEVKEISLDS 1205
Score = 50.8 bits (120), Expect = 3e-06
Identities = 65/304 (21%), Positives = 132/304 (43%), Gaps = 47/304 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
+T+ E ELQ M ++ A + E G + L L++ +E+KS + QL KE+ +
Sbjct: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL----KELTL 2669
Query: 78 LHQQVEEHEKIKQEMTMEYKQELK---KLHEELCILKRSYEKLQKKQMREFRGNTKNHR- 133
E+ ++K+ + +K +++ K+ EE+ + + +KK K +
Sbjct: 2670 ------ENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
E ++ E+LT+K E + L+ + + ++ +SL+A + L E
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE-------------- 2769
Query: 194 KLESVELSSQSEIQHLSSKLERANDTI-----CANELEIERLTMRVNDLVGTSMTVLQEQ 248
L+ ++ + + L + ERA + +LE E+ +++ ++ LQ
Sbjct: 2770 -LKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEK------EILQKELSQLQAA 2822
Query: 249 QQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHE-------ARIQKEKLQEKVKATN 301
Q+K++ + ++ L E +ELK L+ + E I EKL++ +
Sbjct: 2823 QEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882
Query: 302 TQHA 305
TQ A
Sbjct: 2883 TQVA 2886
Score = 46.6 bits (109), Expect = 5e-05
Identities = 90/461 (19%), Positives = 189/461 (40%), Gaps = 65/461 (14%)
Query: 86 EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHREDRSEI 139
E+ K+ + Q++++L +L LK+ ++ Q + +++ + +N + + + +
Sbjct: 6 EEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL 65
Query: 140 ERLTAKIEEFRQKSLDWEKQRL-----IYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
+R ++ E + SL+ KQ++ + + QV+ E Q + +Q E ++ +L K +
Sbjct: 66 KRENQRLMEICE-SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 195 LESVELSSQSEIQHLS---------------------SKLERANDTICANELEIERLTMR 233
LE + ++QS L+ SK E + E +RL
Sbjct: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAE 184
Query: 234 VNDLVG--TSMTVLQEQQQKEEKLR-ESEKLLEALQEEKRELKAALQSQENLI------- 283
V L S T+ Q + R ++ + + Q+EK + SQ I
Sbjct: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
Query: 284 -----HEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELK-RMEA 337
E + LQ + N+ + S + K +QEL K EL+ R++
Sbjct: 245 YFSGEQEVTPSRSTLQIGKRDANSSF-FDNSSSPHLLDQLKAQNQELRNKINELELRLQG 303
Query: 338 HNNEYKAEIKKLKEQILQGEQSYSSALEGMKM------EISHLTQELHQRDITIASTKGS 391
H E K ++ K +E LQ E++ +E K+ E+ T + Q ASTK +
Sbjct: 304 HEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ-----ASTKYT 358
Query: 392 SSDME-KRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSP 450
+ + + K+L ++ A + L+Q +K + + E + + +
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQ--KIKEKEKEFQEELSRQQRSFQTLDQECIQ 416
Query: 451 LGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQF 491
+ + T+ L++ + H++L+ + +K++ E + +F
Sbjct: 417 MKARLTQELQQAK-NMHNVLQAELDKLTSVKQQLENNLEEF 456
Score = 42.7 bits (99), Expect = 8e-04
Identities = 97/438 (22%), Positives = 177/438 (40%), Gaps = 44/438 (10%)
Query: 5 LEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSL 64
L+ +Q++ G L CE + +E I H+ S + L+ L+ +L L
Sbjct: 1250 LQDMQSQEISG--LKDCEIDAEEKY----ISGPHELSTSQNDNAHLQCSLQTTMNKLNEL 1303
Query: 65 RSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE 124
++ E L ++ + T + +E+ KL E+ IL L + + +
Sbjct: 1304 EKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVED 1363
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSL---DWEKQRLI--YQQQVSSLEAQRKALAE 179
G + + L E + L D E Q Q++ SL+++ K L +
Sbjct: 1364 IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHD 1423
Query: 180 QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLER-ANDTICANELEIERLTMRVNDLV 238
Q Q+ ++ +L++ S ++E LS+ L D + +L +E LV
Sbjct: 1424 Q----HCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE------GLV 1473
Query: 239 GTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE------LKAALQSQENLIHEARIQKEK 292
+ + L +S AL E+ + L+ A+ + + + E +
Sbjct: 1474 PSLSSSCVPDSSSLSSLGDSS-FYRALLEQTGDMSLLSNLEGAVSANQCSVDE--VFCSS 1530
Query: 293 LQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ 352
LQE+ + A +E + + C+ Q L EK EE +ME+ EI++L EQ
Sbjct: 1531 LQEENLTRKETPSAPAKGVEELESLCEVYRQSL-EKLEE--KMESQGIMKNKEIQEL-EQ 1586
Query: 353 ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE 412
+L E+ L K +S E Q+ +T + +ME +L AE ++ E ++E
Sbjct: 1587 LLSSERQELDCLR--KQYLSE--NEQWQQKLTSVTL-----EMESKLAAEKKQTEQLSLE 1637
Query: 413 HKEILDQLESLKLENRHL 430
+ QL+ L L +R L
Sbjct: 1638 LEVARLQLQGLDLSSRSL 1655
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 82.4 bits (202), Expect = 9e-16
Identities = 110/504 (21%), Positives = 224/504 (44%), Gaps = 41/504 (8%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E L+ IQN FL E + + + AH+ + + + + +++ E++L
Sbjct: 634 EEELKDIQNMN----FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL 689
Query: 62 K----SLRSQLDVTHKEVGMLHQQVEEHEKIKQEM-TMEYKQELKKLHEELCILKRSYEK 116
+ + + + + + L +V++ + + E + ++++K +E ++ E+
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 117 LQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKA 176
L + + + + R+E LT ++++ + K D + ++ + +
Sbjct: 750 LLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGK 809
Query: 177 LAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSK-----LERAND-TICANELEIERL 230
+ E+++A+L+ K ++V+ Q EI+ L + LE+A +I + E++ L
Sbjct: 810 IKSVEELLEAELLKVANKEKTVQDLKQ-EIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Query: 231 TMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ--SQENLIH-EAR 287
+ + T VL+E KE+ L + K L+ LQEE LKA +Q +Q NL +
Sbjct: 869 LKGKEEQMNTMKAVLEE---KEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 288 IQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIK 347
Q E+L+ +K + L+ + A K+ +L K + L+ ++ N +K++I+
Sbjct: 926 SQFEELEIVLKEKENE-------LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
Query: 348 KLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAE 407
+LK+Q Q S+ E +K+ IS +E+ + S K + K+ Q+ E
Sbjct: 979 QLKQQNYQQASSFPPHEELLKV-ISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVE 1037
Query: 408 DKAVEHKEILDQL--ESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELR 465
+E KE+L +L + N E + E EC S GS EE ++
Sbjct: 1038 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTS--GS------EEVKVL 1089
Query: 466 SHHILERLDAH-IEELKRESEKTV 488
H + E + H + +L+ E K+V
Sbjct: 1090 EHKLKEADEMHTLLQLECEKYKSV 1113
Score = 66.6 bits (161), Expect = 5e-11
Identities = 110/555 (19%), Positives = 220/555 (39%), Gaps = 128/555 (23%)
Query: 16 GFLTSCEAELQE---LMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTH 72
G LT+ +LQE L+ + A K + T + T + + ++ ++
Sbjct: 325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
Query: 73 KEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH 132
KE + ++ + Q+M M+++Q +++ E+ LK+ + +R+ NT N
Sbjct: 385 KEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ-----ENGILRDAVSNTTNQ 439
Query: 133 REDRSEIE---------RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEI 183
E + E RL ++ E K E Q+ +Q + L+ Q + + E
Sbjct: 440 LESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE 499
Query: 184 IQAQLVNR-------KQKLESVELSSQSEIQHLSSKLERANDTICANEL----------- 225
+Q+ + R +Q L+S ++ ++E+Q L SKL DT+ + +
Sbjct: 500 VQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL---TDTLVSKQQLEQRLMQLMES 556
Query: 226 ------EIERLTMRVNDLVG-------------------TSMTVLQEQ------------ 248
+ E L M+V D++ TS +VL E+
Sbjct: 557 EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
Query: 249 --------------QQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
KEE+L++ + + L+ E ++L+A Q HE EK+Q
Sbjct: 617 KQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL----EKMQ 672
Query: 295 EKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 354
+ V + + + +QL E+ K EE K + N K+E++KL Q L
Sbjct: 673 QSVYVKD----------DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL--QTL 720
Query: 355 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHK 414
EQ +E M+ I + +++L+ + E ++
Sbjct: 721 VSEQPNKDVVEQMEKCI---------------------QEKDEKLKTVEELLETGLIQVA 759
Query: 415 EILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLD 474
++L +++ EN L++ V L+ ++ + + L + + E++ + + E L+
Sbjct: 760 TKEEELNAIRTENSSLTKEVQDLKAKQND-QVSFASLVEELKKVIHEKDGKIKSVEELLE 818
Query: 475 AHIEELKRESEKTVR 489
A + ++ + EKTV+
Sbjct: 819 AELLKVANK-EKTVQ 832
Score = 62.0 bits (149), Expect = 1e-09
Identities = 105/493 (21%), Positives = 211/493 (42%), Gaps = 87/493 (17%)
Query: 26 QELMKQIDIMVAHKKSEWEGRTHALETCL---KIREQELKSLRSQLDVTHKEVGMLHQQ- 81
+++++Q++ + K + + LET L +E+EL ++R++ KEV L +
Sbjct: 727 KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQ 786
Query: 82 ---------VEEHEKI------------------------KQEMTMEYKQELKKLHEEL- 107
VEE +K+ K++ + KQE+K L EE+
Sbjct: 787 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIG 846
Query: 108 -CILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ 166
L+++ + +++E + K E ++ + A +EE + + K Q++
Sbjct: 847 NVQLEKAQQLSITSKVQELQNLLKGKEE---QMNTMKAVLEEKEKDLANTGKWLQDLQEE 903
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKL-ERANDTICANEL 225
SL+A + +A Q + +A ++ ++LE V ++E++ L + L ER +D +++
Sbjct: 904 NESLKAHVQEVA-QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL--SSKT 960
Query: 226 EIERLTMRVNDLVGTSMTVLQEQQ-QKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
++ + N L + + L++Q Q+ E+LL+ + E ++E+ ++L
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 285 EARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELM--------------EKYE 330
Q++K E+ Q VEA+ LE+ K + + +K +
Sbjct: 1021 AVEHQRKKNNER------QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1074
Query: 331 ELKRMEAHNNEYKAEIKKLKEQ-----ILQGE-QSYSSAL---EGMKMEISHLTQ----- 376
E + + E K KLKE +LQ E + Y S L EG+ ++ +
Sbjct: 1075 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1134
Query: 377 ------ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHL 430
E H+ + S+ SS +RLR+E + E+ E + + +LE ++E
Sbjct: 1135 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1194
Query: 431 SEMVMKLELGLHE 443
V +L+ L+E
Sbjct: 1195 VTEVRELKAQLNE 1207
Score = 54.7 bits (130), Expect = 2e-07
Identities = 78/395 (19%), Positives = 155/395 (39%), Gaps = 38/395 (9%)
Query: 83 EEHEKIK-QEMTMEYKQELKKLHEELCILKRSYEK---LQKKQMREFRGNTKNHREDRSE 138
+E+ ++K ++ + K + E LC++ EK +Q + +G E
Sbjct: 277 KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQE 336
Query: 139 IERLTAKIEEFRQKSLD----------WEKQR-----LIYQQQVSSLEAQRKALAEQSEI 183
++L A ++E + D EK+R + ++ +LE + + +
Sbjct: 337 KDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHV 396
Query: 184 IQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTIC--ANELEIERLTMRVNDLVGTS 241
+ + K + V ++EI HL + D + N+LE ++ + +N L
Sbjct: 397 SYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQ-SAELNKLRQDY 455
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE-------NLIHEARIQKEKLQ 294
++ E +K KL++ E + ++ +LK LQ E + I + + E Q
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ 515
Query: 295 EKVKATNTQHAVEAISLES----VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK 350
+ +++ E SL S + +QL Q LM+ E ++ + +++ +
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 575
Query: 351 EQ--ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAED 408
EQ L+ + + + S L +ELH+ IA E L +E +
Sbjct: 576 EQNEALKAQIQQFHSQIAAQTSASVLAEELHK---VIAEKDKQIKQTEDSLASERDRLTS 632
Query: 409 KAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
K E K+I + LK E + L + + HE
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
Score = 49.7 bits (117), Expect = 6e-06
Identities = 66/315 (20%), Positives = 138/315 (43%), Gaps = 41/315 (13%)
Query: 51 ETCLKI---REQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEEL 107
E LK+ RE+E+ L ++LD V ++ E ++ + + +E K+ LKKL ++
Sbjct: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKV 1054
Query: 108 CILKR--------SYEKLQKKQMREFRGNTK----NHREDRSEIERLTAKIEEFRQKSLD 155
+ +EK K+ M G+ + H+ ++ ++E + KS+
Sbjct: 1055 SVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVL 1114
Query: 156 WEKQRLIY--QQQVSSLEAQRKALAEQS----EIIQAQLVNRKQKLESVELSSQS----- 204
E + ++ Q+ V E + K ++S + +Q+ + +Q+LE + ++
Sbjct: 1115 AETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLR 1174
Query: 205 -EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLE 263
E +HL +LE+A E+ L ++N+ + T E+Q+ L ++++ LE
Sbjct: 1175 REREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE 1234
Query: 264 ALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQ 323
+Q + +KAA +I + + E T+ + + S++ T QL Q
Sbjct: 1235 LIQ--SKIVKAA--GDTTVIENSDVSPE----------TESSEKETMSVSLNQTVTQLQQ 1280
Query: 324 ELMEKYEELKRMEAH 338
L ++L + + H
Sbjct: 1281 LLQAVNQQLTKEKEH 1295
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 82.4 bits (202), Expect = 9e-16
Identities = 96/445 (21%), Positives = 196/445 (44%), Gaps = 51/445 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+++ + + ++E + A E C +Q +K+ + QL+ KE ++++
Sbjct: 874 EEKMVSLLQEKNDLQLQVQAEQDNLADAEERC----DQLIKN-KIQLEAKVKE---MNER 925
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
+E+ E++ E+T + + KL +E LKR + L+ +K+ KN E+
Sbjct: 926 LEDEEEMNAELTAKKR----KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEE 981
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEAQRKAL 177
+ ++ + AK+ +E Q++LD K ++ +QQV LE
Sbjct: 982 MAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS---- 1037
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL 237
EQ + ++ L K+KLE +Q I L + ++ ++ + + E+ L R+ D
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIED- 1096
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKV 297
L Q QK KL+E + +E L+EE + A E L + + E++ E++
Sbjct: 1097 ----EQALGSQLQK--KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 298 KATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAE-IKKLKEQI--- 353
+ +V+ + A +++ ++L E + + A + A+ + +L EQI
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210
Query: 354 LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH 413
+ +Q K+E+ +T + Q A+ + +E ++ KAE+
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Query: 414 KEILDQLESLKLENRHLSEMVMKLE 438
++ Q L+ EN LS + + E
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKE 1295
Score = 75.9 bits (185), Expect = 8e-14
Identities = 108/527 (20%), Positives = 226/527 (42%), Gaps = 96/527 (18%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
LQE + ++ + A K S E H L+ E++ L ++ ++ L ++
Sbjct: 1397 LQEAEEAVEAVNA-KCSSLEKTKHRLQN-------EIEDLMVDVERSNAAAAALDKKQRN 1448
Query: 85 HEKIKQEMTMEYKQ----------ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
+KI E +Y++ E + L EL LK +YE+ + + F+ KN +E
Sbjct: 1449 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE-SLEHLETFKRENKNLQE 1507
Query: 135 DRS--------------EIERLTAKIE----------EFRQKSLDWEKQRLIYQQ-QVSS 169
+ S E+E++ ++E E + SL+ E+ +++ Q + +
Sbjct: 1508 EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ 1567
Query: 170 LEAQ-RKALAEQSEIIQAQLVNRKQKLESVELS------SQSEIQHLSSKLERANDTICA 222
++A+ + LAE+ E ++ N + ++S++ S S++E + K+E
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD-----L 1622
Query: 223 NELEIE-----RLTMRVNDLVGTSMTVLQEQQ-QKEEKLRESEKLLE----------ALQ 266
NE+EI+ R+ V + ++L++ Q Q ++ +R ++ L E LQ
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ 1682
Query: 267 EEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELM 326
E EL+A ++ E A + + E+V+ ++Q+ + + A QL E+
Sbjct: 1683 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVE 1742
Query: 327 EKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR--DIT 384
E +E + E + + + E+ L+ EQ S+ LE MK + ++L R +
Sbjct: 1743 EAVQECRNAEEKAKKAITDAAMMAEE-LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1801
Query: 385 IASTKGSSSDMEKRLRAEMQKAEDK-AVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 443
+ KG ++K L A +++ E++ E K + ++ ++ R + E+ + E
Sbjct: 1802 QIALKGGKKQLQK-LEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEED--- 1857
Query: 444 CSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
+ LR ++++L ++ KR++E+ Q
Sbjct: 1858 ----------------RKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888
Score = 73.6 bits (179), Expect = 4e-13
Identities = 119/513 (23%), Positives = 211/513 (41%), Gaps = 89/513 (17%)
Query: 44 EGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMT---MEYKQEL 100
E R+ A ET ++ + L SQ E G L +Q++E E + ++T + Y Q+L
Sbjct: 1258 EHRSKAEET-----QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 101 ----KKLHEELCILKRSYEKLQ--KKQMREFRGNTKNHREDRSEIERLTAKIE-EFRQKS 153
++L EE+ LQ + R + E ++E++R+ +K E Q
Sbjct: 1313 EDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 154 LDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ--AQLVNRK-QKLESVELSSQSEIQHLS 210
+E + Q+ LE +K LA++ + + + VN K LE + Q+EI+ L
Sbjct: 1373 TKYETDAI---QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKR 270
+ER+N A + + +L E +QK E ES+ LE+ Q+E R
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDK-----------ILAEWKQKYE---ESQSELESSQKEAR 1475
Query: 271 ELKAALQSQENLIHEA-------RIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQ 323
L L +N E+ + + + LQE++ Q ++ + KQL
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535
Query: 324 ELMEKYEELKRMEA--------------HNNEYKAEI-KKLKEQILQGEQSYSSALEGMK 368
E ME L+ EA N+ KAEI +KL E+ + EQ+ + L +
Sbjct: 1536 EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVD 1595
Query: 369 MEISHLTQELHQRDITIASTK---GSSSDME------KRLRAEMQKAEDKAVEH--KEIL 417
+ L E R+ + K G ++ME R+ AE QK + K+++ K+
Sbjct: 1596 SLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQK-QVKSLQSLLKDTQ 1654
Query: 418 DQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILE------ 471
QL+ N L E + +E + + L ++ + +L ++E
Sbjct: 1655 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 1714
Query: 472 --------------RLDAHIEELKRESEKTVRQ 490
++DA + +L+ E E+ V++
Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Score = 65.1 bits (157), Expect = 1e-10
Identities = 85/442 (19%), Positives = 191/442 (43%), Gaps = 52/442 (11%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER- 141
EE ++K+ + + K+L E++ L + LQ + E + N + E ++ +
Sbjct: 854 EEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDLQLQVQAE-QDNLADAEERCDQLIKN 911
Query: 142 ---LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
L AK++E ++ D E+ + LE + L + ++ L K+E
Sbjct: 912 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLA----KVEKE 967
Query: 199 ELSSQSEIQHLSSKLERANDTIC-----------ANELEIERLTM---RVNDLVGTSMTV 244
+ ++++++++L+ ++ ++ I A++ ++ L +VN L + +
Sbjct: 968 KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL 1027
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH 304
Q+ E L + +K+ L+ KR+L+ L+ + I + K++L E++K + +
Sbjct: 1028 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL 1087
Query: 305 AVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 364
+E A QL ++L E +A I++L+E+ L+ E++ + +
Sbjct: 1088 NALNARIEDEQALGSQLQKKL--------------KELQARIEELEEE-LEAERTARAKV 1132
Query: 365 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK----AEDKAVEH------- 413
E ++ ++S +E+ +R +M K+ AE QK E+ ++H
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 414 -KEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILER 472
K+ D + L + +L + KLE E L + + S + + + + +
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII-KAKANLEKMCRT 1251
Query: 473 LDAHIEELKRESEKTVRQFTAL 494
L+ + E + ++E+T R L
Sbjct: 1252 LEDQMNEHRSKAEETQRSVNDL 1273
Score = 33.5 bits (75), Expect = 0.46
Identities = 43/252 (17%), Positives = 109/252 (43%), Gaps = 39/252 (15%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
+E +L+ + + ++K + + L+T ++ QE ++ + + M+ +++
Sbjct: 1710 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1769
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
+ K++ T + + +KK E+ +K +L + + +G K ++++L
Sbjct: 1770 K-----KEQDTSAHLERMKKNMEQT--IKDLQHRLDEAEQIALKGGKK-------QLQKL 1815
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS 202
A++ E + LEA++K AE + + RK + EL+
Sbjct: 1816 EARVRELE-----------------NELEAEQKRNAESVKGM------RKSERRIKELTY 1852
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL 262
Q+E L R D + +L+++ + + + T L + ++ + +L E+E+
Sbjct: 1853 QTEEDR--KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 263 EALQEEKRELKA 274
+ + + +L+A
Sbjct: 1911 DIAESQVNKLRA 1922
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,227,882
Number of Sequences: 37866
Number of extensions: 725668
Number of successful extensions: 16485
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 522
Number of HSP's successfully gapped in prelim test: 1245
Number of HSP's that attempted gapping in prelim test: 5417
Number of HSP's gapped (non-prelim): 5576
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.