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Search of human proteins with 10880979
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10880979 lymphocyte-specific protein 1 isoform 1 [Homo
sapiens]
(339 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10880979 lymphocyte-specific protein 1 isoform 1 [Homo sapiens] 687 0.0
gi|61742793 lymphocyte-specific protein 1 isoform 2 [Homo sapiens] 559 e-159
gi|61742791 lymphocyte-specific protein 1 isoform 2 [Homo sapiens] 559 e-159
gi|61742789 lymphocyte-specific protein 1 isoform 2 [Homo sapiens] 559 e-159
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 71 1e-12
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 71 1e-12
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 70 4e-12
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 70 4e-12
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 70 4e-12
gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] 58 1e-08
gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] 58 1e-08
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 57 2e-08
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 57 2e-08
gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] 57 3e-08
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 49 6e-06
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 46 4e-05
gi|210032580 SET domain containing 1B [Homo sapiens] 46 5e-05
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 45 9e-05
gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo s... 44 2e-04
gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo sa... 44 2e-04
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 42 8e-04
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 42 8e-04
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 42 0.001
gi|110347429 mediator complex subunit 12 [Homo sapiens] 42 0.001
gi|38176300 nestin [Homo sapiens] 40 0.002
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 40 0.002
gi|92087055 PERQ amino acid rich, with GYF domain 1 [Homo sapiens] 40 0.002
gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Hom... 40 0.003
gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Hom... 40 0.003
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 40 0.004
>gi|10880979 lymphocyte-specific protein 1 isoform 1 [Homo sapiens]
Length = 339
Score = 687 bits (1772), Expect = 0.0
Identities = 339/339 (100%), Positives = 339/339 (100%)
Query: 1 MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPK 60
MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPK
Sbjct: 1 MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPK 60
Query: 61 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRP 120
QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRP
Sbjct: 61 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRP 120
Query: 121 GLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLV 180
GLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLV
Sbjct: 121 GLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLV 180
Query: 181 LEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIET 240
LEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIET
Sbjct: 181 LEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIET 240
Query: 241 AGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQK 300
AGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQK
Sbjct: 241 AGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQK 300
Query: 301 GGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 339
GGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
Sbjct: 301 GGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 339
>gi|61742793 lymphocyte-specific protein 1 isoform 2 [Homo sapiens]
Length = 277
Score = 559 bits (1441), Expect = e-159
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 63 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL 122
MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL
Sbjct: 1 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL 60
Query: 123 HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE 182
HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE
Sbjct: 61 HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE 120
Query: 183 GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG 242
GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG
Sbjct: 121 GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG 180
Query: 243 RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG 302
RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG
Sbjct: 181 RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG 240
Query: 303 SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 339
SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
Sbjct: 241 SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 277
>gi|61742791 lymphocyte-specific protein 1 isoform 2 [Homo sapiens]
Length = 277
Score = 559 bits (1441), Expect = e-159
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 63 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL 122
MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL
Sbjct: 1 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL 60
Query: 123 HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE 182
HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE
Sbjct: 61 HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE 120
Query: 183 GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG 242
GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG
Sbjct: 121 GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG 180
Query: 243 RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG 302
RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG
Sbjct: 181 RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG 240
Query: 303 SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 339
SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
Sbjct: 241 SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 277
>gi|61742789 lymphocyte-specific protein 1 isoform 2 [Homo sapiens]
Length = 277
Score = 559 bits (1441), Expect = e-159
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 63 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL 122
MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL
Sbjct: 1 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL 60
Query: 123 HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE 182
HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE
Sbjct: 61 HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLE 120
Query: 183 GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG 242
GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG
Sbjct: 121 GTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAG 180
Query: 243 RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG 302
RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG
Sbjct: 181 RTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGG 240
Query: 303 SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 339
SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
Sbjct: 241 SKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP 277
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 71.2 bits (173), Expect = 1e-12
Identities = 86/372 (23%), Positives = 149/372 (40%), Gaps = 87/372 (23%)
Query: 26 EDEEE-----AVHEQCQHERDRQLQAQDEEGGGHVPERPKQEML-LSLKPSEAPE----- 74
E+EEE ++ E E+ ++QA+ E+ P K+E+ +K + P+
Sbjct: 186 EEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 245
Query: 75 -LDEDEGFGDWSQRPEQRQQHE-----------GAQGALDSGEPP------------QCR 110
+D +GF + + + H+ G + ++D+ E + R
Sbjct: 246 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 305
Query: 111 SPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEG------PGPEDTVQDNLGAAGAEEEQ 164
GE E +K+ + LEEL +E + Q+ EEE+
Sbjct: 306 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 365
Query: 165 E-------EHQKCQQPRTPSPLVLEGTIEQSSP-----PLSPTTKLIDRTESLNRSIEKS 212
+ E ++ + + +G + P P + K+ +R E LN+S++KS
Sbjct: 366 KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 425
Query: 213 NSVKKSQPDLPISKIDQWLEQYTQAIE-TAGRTPKLARQASIELPSMAVASTKSRWETGE 271
+ VK + +SKID LEQYT AIE T P + + +P+ V + KS WE G
Sbjct: 426 SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN 485
Query: 272 V-QAQSAAKTPSCK-------------------------------DIVAGDM-SKKSLWE 298
V + +AA TP+ + D+ GD+ SK++LWE
Sbjct: 486 VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 545
Query: 299 QKGGSKTSSTIK 310
++ K +S K
Sbjct: 546 KQSVDKVTSPTK 557
Score = 31.2 bits (69), Expect = 1.4
Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 9/77 (11%)
Query: 26 EDEEEAVHEQCQHERDRQL-QAQDEEGGGHVPERPKQEMLLSLKPSEAP--------ELD 76
+DEEEA E+ + R +L Q Q+EE G V ++ + S+ EA E D
Sbjct: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
Query: 77 EDEGFGDWSQRPEQRQQ 93
++ F + R E+R+Q
Sbjct: 86 DEAAFLERLARREERRQ 102
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 71.2 bits (173), Expect = 1e-12
Identities = 86/372 (23%), Positives = 149/372 (40%), Gaps = 87/372 (23%)
Query: 26 EDEEE-----AVHEQCQHERDRQLQAQDEEGGGHVPERPKQEML-LSLKPSEAPE----- 74
E+EEE ++ E E+ ++QA+ E+ P K+E+ +K + P+
Sbjct: 192 EEEEEKPKRGSIGENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 251
Query: 75 -LDEDEGFGDWSQRPEQRQQHE-----------GAQGALDSGEPP------------QCR 110
+D +GF + + + H+ G + ++D+ E + R
Sbjct: 252 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 311
Query: 111 SPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEG------PGPEDTVQDNLGAAGAEEEQ 164
GE E +K+ + LEEL +E + Q+ EEE+
Sbjct: 312 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 371
Query: 165 E-------EHQKCQQPRTPSPLVLEGTIEQSSP-----PLSPTTKLIDRTESLNRSIEKS 212
+ E ++ + + +G + P P + K+ +R E LN+S++KS
Sbjct: 372 KRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 431
Query: 213 NSVKKSQPDLPISKIDQWLEQYTQAIE-TAGRTPKLARQASIELPSMAVASTKSRWETGE 271
+ VK + +SKID LEQYT AIE T P + + +P+ V + KS WE G
Sbjct: 432 SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGN 491
Query: 272 V-QAQSAAKTPSCK-------------------------------DIVAGDM-SKKSLWE 298
V + +AA TP+ + D+ GD+ SK++LWE
Sbjct: 492 VFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWE 551
Query: 299 QKGGSKTSSTIK 310
++ K +S K
Sbjct: 552 KQSVDKVTSPTK 563
Score = 31.2 bits (69), Expect = 1.4
Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 9/77 (11%)
Query: 26 EDEEEAVHEQCQHERDRQL-QAQDEEGGGHVPERPKQEMLLSLKPSEAP--------ELD 76
+DEEEA E+ + R +L Q Q+EE G V ++ + S+ EA E D
Sbjct: 32 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 91
Query: 77 EDEGFGDWSQRPEQRQQ 93
++ F + R E+R+Q
Sbjct: 92 DEAAFLERLARREERRQ 108
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 69.7 bits (169), Expect = 4e-12
Identities = 68/271 (25%), Positives = 110/271 (40%), Gaps = 52/271 (19%)
Query: 92 QQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEG------P 145
++ EGA + R GE E +K+ + LEEL +E
Sbjct: 261 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 320
Query: 146 GPEDTVQDNLGAAGAEEEQE-------EHQKCQQPRTPSPLVLEGTIEQSSP-----PLS 193
+ Q+ EEE++ E ++ + + +G + P P
Sbjct: 321 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 380
Query: 194 PTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIE-TAGRTPKLARQAS 252
+ K+ +R E LN+S++KS+ VK + +SKID LEQYT AIE T P +
Sbjct: 381 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 440
Query: 253 IELPSMAVASTKSRWETGEV-QAQSAAKTPSCK--------------------------- 284
+ +P+ V + KS WE G V + +AA TP+ +
Sbjct: 441 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 500
Query: 285 ----DIVAGDM-SKKSLWEQKGGSKTSSTIK 310
D+ GD+ SK++LWE++ K +S K
Sbjct: 501 PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 531
Score = 33.1 bits (74), Expect = 0.36
Identities = 44/199 (22%), Positives = 79/199 (39%), Gaps = 24/199 (12%)
Query: 26 EDEEEAVHEQCQHERDRQL-QAQDEEGGGHVPERPKQEMLLSLKPSEAP--------ELD 76
+DEEEA E+ + R +L Q Q+EE G V ++ + S+ EA E D
Sbjct: 26 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 85
Query: 77 EDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGE--------QEDRPGLHAYEKE 128
++ F + R E+R+Q + Q AL+ + + Q D EKE
Sbjct: 86 DEAAFLERLARREERRQ-KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 144
Query: 129 DSDEVHLEELSLSKEGPGPEDTVQDNLGAA------GAEEEQEEHQKCQQPRTPSPLVLE 182
+ E E + + + +++ A E+E+EE +K ++ + +
Sbjct: 145 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 204
Query: 183 GTIEQSSPPLSPTTKLIDR 201
I++ P +DR
Sbjct: 205 EKIKKDKEPKEEVKSFMDR 223
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 69.7 bits (169), Expect = 4e-12
Identities = 68/271 (25%), Positives = 110/271 (40%), Gaps = 52/271 (19%)
Query: 92 QQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEG------P 145
++ EGA + R GE E +K+ + LEEL +E
Sbjct: 267 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 326
Query: 146 GPEDTVQDNLGAAGAEEEQE-------EHQKCQQPRTPSPLVLEGTIEQSSP-----PLS 193
+ Q+ EEE++ E ++ + + +G + P P
Sbjct: 327 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 386
Query: 194 PTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIE-TAGRTPKLARQAS 252
+ K+ +R E LN+S++KS+ VK + +SKID LEQYT AIE T P +
Sbjct: 387 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 446
Query: 253 IELPSMAVASTKSRWETGEV-QAQSAAKTPSCK--------------------------- 284
+ +P+ V + KS WE G V + +AA TP+ +
Sbjct: 447 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 506
Query: 285 ----DIVAGDM-SKKSLWEQKGGSKTSSTIK 310
D+ GD+ SK++LWE++ K +S K
Sbjct: 507 PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 537
Score = 33.1 bits (74), Expect = 0.36
Identities = 44/199 (22%), Positives = 79/199 (39%), Gaps = 24/199 (12%)
Query: 26 EDEEEAVHEQCQHERDRQL-QAQDEEGGGHVPERPKQEMLLSLKPSEAP--------ELD 76
+DEEEA E+ + R +L Q Q+EE G V ++ + S+ EA E D
Sbjct: 32 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 91
Query: 77 EDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGE--------QEDRPGLHAYEKE 128
++ F + R E+R+Q + Q AL+ + + Q D EKE
Sbjct: 92 DEAAFLERLARREERRQ-KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 150
Query: 129 DSDEVHLEELSLSKEGPGPEDTVQDNLGAA------GAEEEQEEHQKCQQPRTPSPLVLE 182
+ E E + + + +++ A E+E+EE +K ++ + +
Sbjct: 151 EKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKD 210
Query: 183 GTIEQSSPPLSPTTKLIDR 201
I++ P +DR
Sbjct: 211 EKIKKDKEPKEEVKSFMDR 229
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 69.7 bits (169), Expect = 4e-12
Identities = 68/271 (25%), Positives = 110/271 (40%), Gaps = 52/271 (19%)
Query: 92 QQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEG------P 145
++ EGA + R GE E +K+ + LEEL +E
Sbjct: 522 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 581
Query: 146 GPEDTVQDNLGAAGAEEEQE-------EHQKCQQPRTPSPLVLEGTIEQSSP-----PLS 193
+ Q+ EEE++ E ++ + + +G + P P
Sbjct: 582 EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 641
Query: 194 PTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIE-TAGRTPKLARQAS 252
+ K+ +R E LN+S++KS+ VK + +SKID LEQYT AIE T P +
Sbjct: 642 SSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
Query: 253 IELPSMAVASTKSRWETGEV-QAQSAAKTPSCK--------------------------- 284
+ +P+ V + KS WE G V + +AA TP+ +
Sbjct: 702 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPA 761
Query: 285 ----DIVAGDM-SKKSLWEQKGGSKTSSTIK 310
D+ GD+ SK++LWE++ K +S K
Sbjct: 762 PKPSDLRPGDVSSKRNLWEKQSVDKVTSPTK 792
Score = 31.6 bits (70), Expect = 1.1
Identities = 48/212 (22%), Positives = 84/212 (39%), Gaps = 22/212 (10%)
Query: 26 EDEEEAVHEQCQHERDRQL-QAQDEEGGGHVPERPKQEMLLSLKPSEAP--------ELD 76
+DEEEA E+ + R +L Q Q+EE G V ++ + S+ EA E D
Sbjct: 32 DDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD 91
Query: 77 EDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGE--------QEDRPGLHAYEKE 128
++ F + R E+R+Q + Q AL+ + + Q D EKE
Sbjct: 92 DEAAFLERLARREERRQ-KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKE 150
Query: 129 DSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQS 188
+ E E + +E + Q N AEE ++E ++ ++ P G+I ++
Sbjct: 151 EKSESRQERYEI-EETETVTKSYQKN-DWRDAEENKKEDKEKEEEEEEKP--KRGSIGEN 206
Query: 189 SPPLSPTTKLIDRTESLNRSIEKSNSVKKSQP 220
+ K + E K+ + +P
Sbjct: 207 QVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
>gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 58.2 bits (139), Expect = 1e-08
Identities = 28/31 (90%), Positives = 29/31 (93%)
Query: 258 MAVASTKSRWETGEVQAQSAAKTPSCKDIVA 288
MAVASTKSRWETGEVQAQSAAKTPSCK +A
Sbjct: 1 MAVASTKSRWETGEVQAQSAAKTPSCKAQIA 31
>gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 58.2 bits (139), Expect = 1e-08
Identities = 28/31 (90%), Positives = 29/31 (93%)
Query: 258 MAVASTKSRWETGEVQAQSAAKTPSCKDIVA 288
MAVASTKSRWETGEVQAQSAAKTPSCK +A
Sbjct: 1 MAVASTKSRWETGEVQAQSAAKTPSCKAQIA 31
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 57.0 bits (136), Expect = 2e-08
Identities = 63/275 (22%), Positives = 114/275 (41%), Gaps = 38/275 (13%)
Query: 61 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRP 120
+E+ +S+K + +E E + PE ++ A+ + P+ + EGE+E+
Sbjct: 478 EELAVSMKEEKKEAAEEKE------EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEE 531
Query: 121 GLHAYEKED----SDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEE---------H 167
G E+ED SD+ EE KEG ++ + G AE E EE
Sbjct: 532 GQEEEEEEDEGAKSDQA--EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE 589
Query: 168 QKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRS-IEKSNSVKKSQPDLPISK 226
+K ++ T LV + +E+ SP K E +S + KS +K + +P S
Sbjct: 590 EKSEEVATKEELVADAKVEKPEKAKSPVPK--SPVEEKGKSPVPKSPVEEKGKSPVPKSP 647
Query: 227 IDQWLEQYT--QAIETAGRTP----KLARQASIELPSMAVASTKSRWETG-----EVQAQ 275
+++ + +E G++P + +A +P V KS+ E G E + +
Sbjct: 648 VEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 707
Query: 276 SAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIK 310
+ P + + + K + E+K K S +K
Sbjct: 708 EVKEAPKEEKVEKKEEKPKDVPEKK---KAESPVK 739
Score = 28.9 bits (63), Expect = 6.9
Identities = 26/139 (18%), Positives = 60/139 (43%), Gaps = 6/139 (4%)
Query: 48 DEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPP 107
+E+ VP+ P +E + + + +E+E + + P++ + + + D E
Sbjct: 675 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK--EVKEAPKEEKVEKKEEKPKDVPEKK 732
Query: 108 QCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEH 167
+ SP E+ + + S +VHLE+ + + P ++ ++ G G EE+
Sbjct: 733 KAESPVKEEAVAEVVTITK---SVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSD 789
Query: 168 QKCQQPRTPSPLVLEGTIE 186
+ + R + + G +E
Sbjct: 790 KGAKGSR-KEDIAVNGEVE 807
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 57.0 bits (136), Expect = 2e-08
Identities = 63/275 (22%), Positives = 114/275 (41%), Gaps = 38/275 (13%)
Query: 61 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRP 120
+E+ +S+K + +E E + PE ++ A+ + P+ + EGE+E+
Sbjct: 102 EELAVSMKEEKKEAAEEKE------EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEE 155
Query: 121 GLHAYEKED----SDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEE---------H 167
G E+ED SD+ EE KEG ++ + G AE E EE
Sbjct: 156 GQEEEEEEDEGAKSDQA--EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE 213
Query: 168 QKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRS-IEKSNSVKKSQPDLPISK 226
+K ++ T LV + +E+ SP K E +S + KS +K + +P S
Sbjct: 214 EKSEEVATKEELVADAKVEKPEKAKSPVPK--SPVEEKGKSPVPKSPVEEKGKSPVPKSP 271
Query: 227 IDQWLEQYT--QAIETAGRTP----KLARQASIELPSMAVASTKSRWETG-----EVQAQ 275
+++ + +E G++P + +A +P V KS+ E G E + +
Sbjct: 272 VEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 331
Query: 276 SAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIK 310
+ P + + + K + E+K K S +K
Sbjct: 332 EVKEAPKEEKVEKKEEKPKDVPEKK---KAESPVK 363
Score = 28.9 bits (63), Expect = 6.9
Identities = 26/139 (18%), Positives = 60/139 (43%), Gaps = 6/139 (4%)
Query: 48 DEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPP 107
+E+ VP+ P +E + + + +E+E + + P++ + + + D E
Sbjct: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK--EVKEAPKEEKVEKKEEKPKDVPEKK 356
Query: 108 QCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEH 167
+ SP E+ + + S +VHLE+ + + P ++ ++ G G EE+
Sbjct: 357 KAESPVKEEAVAEVVTITK---SVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSD 413
Query: 168 QKCQQPRTPSPLVLEGTIE 186
+ + R + + G +E
Sbjct: 414 KGAKGSR-KEDIAVNGEVE 431
>gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 56.6 bits (135), Expect = 3e-08
Identities = 27/31 (87%), Positives = 28/31 (90%)
Query: 258 MAVASTKSRWETGEVQAQSAAKTPSCKDIVA 288
MAVASTKSRWETGEVQAQSA KTPSCK +A
Sbjct: 1 MAVASTKSRWETGEVQAQSATKTPSCKAQIA 31
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 48.9 bits (115), Expect = 6e-06
Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 20/139 (14%)
Query: 5 SSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERP----- 59
++ PG + ++L+ P + E+EEE E + + + ++EEGGG+V + P
Sbjct: 1336 NTSPGEKPEDDLIKPEEEEEEEEEEE--------EEEEEEEGEEEEGGGNVEKDPDGAKS 1387
Query: 60 --KQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQE 117
K+E +S + ++ LD+ E + + P + H+ D + S E E+E
Sbjct: 1388 QEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDA-----DDEDDSHMESAEVEKE 1442
Query: 118 DRPGLHAYEKEDSDEVHLE 136
+ P E ++ E L+
Sbjct: 1443 ELPRESFKEVLENQETFLD 1461
Score = 28.9 bits (63), Expect = 6.9
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 3/64 (4%)
Query: 6 SDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLL 65
S P ER +LL + + S E+EEE E + E + + + +DEE E ++E +
Sbjct: 1051 SRPVTGERGQLLELSKESSEEEEEE---EDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQ 1107
Query: 66 SLKP 69
S P
Sbjct: 1108 SSPP 1111
Score = 28.5 bits (62), Expect = 9.0
Identities = 45/180 (25%), Positives = 67/180 (37%), Gaps = 30/180 (16%)
Query: 85 SQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEG 144
S R RQ Q P+ R GE R L KE S+E EE +E
Sbjct: 1027 STRANSRQSPAKVQSKNKYLHSPESRPVTGE---RGQLLELSKESSEEEEEEEDEEEEEE 1083
Query: 145 PGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPL------------ 192
E+ ++ EEE+EE+ + PR P + I++ P +
Sbjct: 1084 EEEEEEDEEE-EEEEEEEEEEENIQSSPPRLTKPQSV--AIKRKRPFVLKKKRGRKRRRI 1140
Query: 193 --SPTTKLI-DRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAGRTPKLAR 249
S TT+ I + TE LN + S+ + P +I+ +E GR P L +
Sbjct: 1141 NSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIE---------VEEDGRKPVLRK 1191
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 46.2 bits (108), Expect = 4e-05
Identities = 57/220 (25%), Positives = 86/220 (39%), Gaps = 35/220 (15%)
Query: 26 EDEEEAVH-EQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPS-----EAPELDEDE 79
ED+EE + E+ Q D + Q ++ E E P +E+L SL P +P
Sbjct: 297 EDDEETIEVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSS 356
Query: 80 GFGDWSQRPEQRQQHEGAQGALDSGEPPQC-----RSPEGEQEDRPGLHAYEKEDSDEV- 133
D PE+ + E Q L+ PP + P ED A E+E DE
Sbjct: 357 HDSDTRDGPEEGAEEEPPQ-VLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEED 415
Query: 134 -------------HLEELS-LSKEGP-GPEDTVQDNLGA----AGAEEEQEEHQKCQQPR 174
H ELS L++EG E+ +Q GA +G+ E+++E +
Sbjct: 416 TIAAEEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSS 475
Query: 175 TPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNS 214
P EG +E PP ++ D E + E +S
Sbjct: 476 DCEP---EGPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHS 512
Score = 35.4 bits (80), Expect = 0.073
Identities = 52/209 (24%), Positives = 79/209 (37%), Gaps = 26/209 (12%)
Query: 3 EASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVP-----E 57
EA S P +E+E D E E + E G +P +
Sbjct: 2612 EAGSIPNGQEQE----------APDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASD 2661
Query: 58 RPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQE 117
P QE L + + SE EL E + + PE+ Q+ A+ A S SPEG
Sbjct: 2662 EPLQEPLEADRTSE--ELTEAK---TPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSP 2716
Query: 118 DRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGA--AGAEEEQEEHQKCQQPRT 175
RP + S +V + + G P V L EE+E ++ +Q R
Sbjct: 2717 ARPP----RRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRG 2772
Query: 176 PSPLVLEGTIEQSSPPLSPTTKLIDRTES 204
+ ++ G E S+ P SP+ + + ES
Sbjct: 2773 AASTLVPGVSETSASPGSPSVRSMSGPES 2801
Score = 34.7 bits (78), Expect = 0.13
Identities = 35/166 (21%), Positives = 66/166 (39%), Gaps = 16/166 (9%)
Query: 26 EDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWS 85
EDE +A C+ E + + +E + + + E +E+E G +
Sbjct: 467 EDEVDANSSDCEPEGPVEAEEPPQEDSSSQSDSVEDRS----EDEEDEHSEEEETSGSSA 522
Query: 86 QRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELS-LSKEG 144
+ ++ E AQ Q ++ E E++D G+ D ++ + S G
Sbjct: 523 SEESESEESEDAQS--------QSQADEEEEDDDFGVEYLLARDEEQSEADAGSGPPTPG 574
Query: 145 P---GPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQ 187
P GP+ + D AA + + + Q +TP PL+L G + +
Sbjct: 575 PTTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLRE 620
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 45.8 bits (107), Expect = 5e-05
Identities = 50/208 (24%), Positives = 78/208 (37%), Gaps = 28/208 (13%)
Query: 7 DPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLS 66
D G EE E+ Q S E+EEEA E+ + + D D+ E ++ LS
Sbjct: 1030 DSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDD-----DDDSDDRDESENDDEDTALS 1084
Query: 67 -LKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAY 125
+ + DE+E + + E E ++ + S ++E+
Sbjct: 1085 EASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEE 1144
Query: 126 EKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAA-----------GAEEEQE--------E 166
E+E+ +E+ EE S GPED QD AA G EEE + E
Sbjct: 1145 EEEEEEEMVAEE---SMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPE 1201
Query: 167 HQKCQQPRTPSPLVLEGTIEQSSPPLSP 194
+ P P+ +E + PP P
Sbjct: 1202 ERPSMLDEPPLPVGVEEPADSREPPEEP 1229
Score = 33.5 bits (75), Expect = 0.28
Identities = 50/199 (25%), Positives = 75/199 (37%), Gaps = 34/199 (17%)
Query: 2 AEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQ 61
+ + S P + E EE + + E+EEE V E+ + QD E P P
Sbjct: 1123 SSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAV 1182
Query: 62 EMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPG 121
+ L ++E+ + PE+R LD EPP P G +E
Sbjct: 1183 DSL---------GMEEEVDIETEAVAPEER------PSMLD--EPP---LPVGVEEP--- 1219
Query: 122 LHAYEKEDSDEVHLEE---LSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPS- 177
A +E +E L + + LS E P E + L + E EH +P P
Sbjct: 1220 --ADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPL----SPERAPEHDLEVEPEPPMM 1273
Query: 178 -PLVLEGTIEQSSPPLSPT 195
PL L+ + PP P+
Sbjct: 1274 LPLPLQPPLPPPRPPRPPS 1292
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 45.1 bits (105), Expect = 9e-05
Identities = 42/170 (24%), Positives = 69/170 (40%), Gaps = 13/170 (7%)
Query: 3 EASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQE 62
E G EE EE G + E E E + + E + + + ++EEG G E + E
Sbjct: 915 EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEE-EGEWEGEEEEGEGEGEEEGEGE 973
Query: 63 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGL 122
+E EG G+ + + ++ EG + + GE + EGE+E+ +
Sbjct: 974 G------------EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEV 1021
Query: 123 HAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQ 172
+ + E EE +EG E + EEE+EE K Q+
Sbjct: 1022 EGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071
Score = 44.3 bits (103), Expect = 2e-04
Identities = 46/168 (27%), Positives = 75/168 (44%), Gaps = 17/168 (10%)
Query: 8 PGAEEREELLGPTAQWSVEDEEEAVHEQC----QHERDRQLQ--AQDEEGGGHVPERPKQ 61
PG E+E L +W D EE ++ Q ER+++++ ++E G G E ++
Sbjct: 689 PGEGEKE--LAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746
Query: 62 EMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPG 121
E K E E E E ++ E ++ E G + GE + EGE+E+ G
Sbjct: 747 EE--EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGE-EEGDQGEGEEEETEG 803
Query: 122 LHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQK 169
EKE+ EV E+ +EG G + ++ G EEE E ++
Sbjct: 804 -RGEEKEEGGEVEGGEV---EEGKGEREEEEEE--GEGEEEEGEGEEE 845
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/157 (26%), Positives = 69/157 (43%), Gaps = 5/157 (3%)
Query: 11 EEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPK-QEMLLSLKP 69
EE EE G + +E E E+ + ER ++ +A EE G ++ + +E +
Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRG 805
Query: 70 SEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKED 129
E E E EG + E+ ++ E +G + GE + EGE+E+ G +E+
Sbjct: 806 EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE-EEGEGEEEEGEG---KGEEE 861
Query: 130 SDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEE 166
+E EE EG G E+ + G E +EE
Sbjct: 862 GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
Score = 40.8 bits (94), Expect = 0.002
Identities = 44/170 (25%), Positives = 69/170 (40%), Gaps = 15/170 (8%)
Query: 3 EASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQE 62
E + G ++EE G + E ++ E+ R + + E GG V E +
Sbjct: 767 EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826
Query: 63 MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGA---QGALDSGEPPQCRSPEGEQEDR 119
+ E E +E+EG G+ + + ++ EG +G GE + EGE E+
Sbjct: 827 E----EEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE-EGEEGEGEGEEE 881
Query: 120 PGLHAYEKEDSDEVHLEELSLSKEGPGPED---TVQDNLGAAGAEEEQEE 166
G E+E E EE EG G E+ ++ G EEE EE
Sbjct: 882 EGEGEGEEEGEGEGEEEE----GEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
Score = 40.0 bits (92), Expect = 0.003
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 5/168 (2%)
Query: 3 EASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDR-QLQAQDEEGGGHVPERPKQ 61
E + G E EE G + + EEE + + E + + + ++EEG G E +
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEG 893
Query: 62 EMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEG-AQGALDSGEPPQCRSPEGEQEDRP 120
E E E E EG + + + + EG +G + GE + EGE E+
Sbjct: 894 EGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE-GEGEDGEGEGEEEE 952
Query: 121 GLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQ 168
G E+E+ + EE EG E ++ G EEE+ E +
Sbjct: 953 GEWEGEEEEGEGEGEEE--GEGEGEEGEGEGEEEEGEGEGEEEEGEEE 998
Score = 38.1 bits (87), Expect = 0.011
Identities = 41/161 (25%), Positives = 69/161 (42%), Gaps = 10/161 (6%)
Query: 9 GAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLK 68
G EE E G + E+EEE E + +++ + E+ G ER K+E
Sbjct: 731 GEEEHGE--GEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG---ERKKEERA---G 782
Query: 69 PSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKE 128
E E + D+G G+ + E R + + G ++ GE + + E E+E+ G E+
Sbjct: 783 KEEKGEEEGDQGEGE-EEETEGRGEEKEEGGEVEGGEVEEGKG-EREEEEEEGEGEEEEG 840
Query: 129 DSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQK 169
+ +E E EG G E+ + G E E E ++
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881
Score = 37.0 bits (84), Expect = 0.025
Identities = 48/171 (28%), Positives = 70/171 (40%), Gaps = 28/171 (16%)
Query: 3 EASSDPGAEEREELLGPTAQWSVEDEEEAVH-EQCQHERDRQLQAQDEEGGGHVPERPKQ 61
E D G E EE G + E E E+ + ER+ + +EEG G E +
Sbjct: 788 EEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEE----EEEGEGEEEEGEGE 843
Query: 62 EMLLSLKPSEAPELDEDEGFGDWSQRPEQRQ-QHEGAQGALDS------GEPPQCRSPEG 114
E E E +E+EG G + E+ + + EG +G + GE + EG
Sbjct: 844 E--------EEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG 895
Query: 115 EQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQE 165
E+E+ G E E+ E EE +EG G + + G EEE E
Sbjct: 896 EEEEGEG----EGEEEGEGEGEE----EEGEGKGEEEGEEGEGEGEEEEGE 938
Score = 36.6 bits (83), Expect = 0.033
Identities = 38/142 (26%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 26 EDEEEAVHEQCQHE-RDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDW 84
E+EEE E+ + E + + + ++EEG G E ++ E +E+EG G+
Sbjct: 828 EEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEG 887
Query: 85 SQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEG 144
+ E + E +G E + EGE+E+ G E E+ E EE EG
Sbjct: 888 EEEGEGEGEEEEGEG-----EGEEEGEGEGEEEEGEGKGEEEGEEG-EGEGEEEEGEGEG 941
Query: 145 PGPEDTVQDNLGAAGAEEEQEE 166
E ++ G EEE+ E
Sbjct: 942 EDGEGEGEEEEGEWEGEEEEGE 963
Score = 32.7 bits (73), Expect = 0.48
Identities = 44/176 (25%), Positives = 66/176 (37%), Gaps = 28/176 (15%)
Query: 2 AEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQ 61
AE S G EE+E VE EE V + ++ + D V E +
Sbjct: 593 AEDSKGNGIEEQE----------VEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAK 642
Query: 62 EMLLSLKPSEAPELDEDEGFG---DWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQE- 117
+ EA + E G G + S E Q E +G D G R EGE+E
Sbjct: 643 SV------GEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKEL 696
Query: 118 -------DRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEE 166
R G E+++ ++ H +E + E G E+ + EEE+E+
Sbjct: 697 AEKEEWKKRDG-EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751
Score = 30.4 bits (67), Expect = 2.4
Identities = 43/173 (24%), Positives = 68/173 (39%), Gaps = 25/173 (14%)
Query: 2 AEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQ 61
AE S E GP + EE + +H +D + + +++ G ERP +
Sbjct: 634 AEVSEGKAKSVGEAEDGPEGRGDGTCEEGS--SGAEHWQDEEREKGEKDKGRGEMERPGE 691
Query: 62 EMLLSLKPSEAPELDEDEGFGDWSQRP-EQRQQHEGAQG-------ALDSGEPPQCRSPE 113
EL E E +W +R E+++Q E QG ++ G + E
Sbjct: 692 G---------EKELAEKE---EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGE 739
Query: 114 GEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEE 166
E+ DR E E +E EE+ +E E ++ AG EE+ EE
Sbjct: 740 EEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER---AGKEEKGEE 789
>gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo
sapiens]
Length = 1235
Score = 43.9 bits (102), Expect = 2e-04
Identities = 52/207 (25%), Positives = 76/207 (36%), Gaps = 28/207 (13%)
Query: 23 WSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFG 82
W E E H+RDR + +D ER E S PS AP L + G
Sbjct: 785 WLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVN-ALG 843
Query: 83 DWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSK 142
EQ + H + E ++D+P + +S + + +K
Sbjct: 844 HTRSSTEQIRAH---------------LNTEAREKDKPKERERDHSESRKDLAADEHKAK 888
Query: 143 EGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRT 202
EG PE + G A EE + Q R PSP V +E + P + + + R
Sbjct: 889 EGHLPEKDGHGHEGRAAGEEAK------QLARVPSPYVRTPVVESARPNSTSSREAEPRK 942
Query: 203 -ESLNRSIEKSNSVK-----KSQPDLP 223
E + +KS+ VK K DLP
Sbjct: 943 GEPAYENPKKSSEVKVKEERKEDHDLP 969
Score = 30.8 bits (68), Expect = 1.8
Identities = 50/218 (22%), Positives = 79/218 (36%), Gaps = 30/218 (13%)
Query: 33 HEQCQHERDRQLQAQDEEGGGHVPERPKQ-EMLLSLKPSEAPELDEDE----GFGDWSQR 87
H E DR L H+ +R K + L LKP + D D G R
Sbjct: 147 HYSSDRENDRNLCQ-------HLGKRKKMPKALRQLKPGQNSCRDSDSESASGESKGFHR 199
Query: 88 PEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGP 147
R++ + G C S + +QE++ + EK + + ++ L G P
Sbjct: 200 SSSRERLSDSSAPSSLGTGYFCDS-DSDQEEKASDASSEKLFNTVIVNKDPELGV-GTLP 257
Query: 148 EDTVQDN----LGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPL----------- 192
E QD +G E QE+ Q C + P+VL+ Q + P+
Sbjct: 258 EHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRA 317
Query: 193 -SPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQ 229
SP L+ RTE+ + S + P+ + Q
Sbjct: 318 PSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQ 355
>gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo
sapiens]
Length = 1259
Score = 43.9 bits (102), Expect = 2e-04
Identities = 52/207 (25%), Positives = 76/207 (36%), Gaps = 28/207 (13%)
Query: 23 WSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFG 82
W E E H+RDR + +D ER E S PS AP L + G
Sbjct: 809 WLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVN-ALG 867
Query: 83 DWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSK 142
EQ + H + E ++D+P + +S + + +K
Sbjct: 868 HTRSSTEQIRAH---------------LNTEAREKDKPKERERDHSESRKDLAADEHKAK 912
Query: 143 EGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRT 202
EG PE + G A EE + Q R PSP V +E + P + + + R
Sbjct: 913 EGHLPEKDGHGHEGRAAGEEAK------QLARVPSPYVRTPVVESARPNSTSSREAEPRK 966
Query: 203 -ESLNRSIEKSNSVK-----KSQPDLP 223
E + +KS+ VK K DLP
Sbjct: 967 GEPAYENPKKSSEVKVKEERKEDHDLP 993
Score = 30.8 bits (68), Expect = 1.8
Identities = 50/218 (22%), Positives = 79/218 (36%), Gaps = 30/218 (13%)
Query: 33 HEQCQHERDRQLQAQDEEGGGHVPERPKQ-EMLLSLKPSEAPELDEDE----GFGDWSQR 87
H E DR L H+ +R K + L LKP + D D G R
Sbjct: 147 HYSSDRENDRNLCQ-------HLGKRKKMPKALRQLKPGQNSCRDSDSESASGESKGFHR 199
Query: 88 PEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGP 147
R++ + G C S + +QE++ + EK + + ++ L G P
Sbjct: 200 SSSRERLSDSSAPSSLGTGYFCDS-DSDQEEKASDASSEKLFNTVIVNKDPELGV-GTLP 257
Query: 148 EDTVQDN----LGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPL----------- 192
E QD +G E QE+ Q C + P+VL+ Q + P+
Sbjct: 258 EHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRA 317
Query: 193 -SPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQ 229
SP L+ RTE+ + S + P+ + Q
Sbjct: 318 PSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQ 355
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 42.0 bits (97), Expect = 8e-04
Identities = 32/161 (19%), Positives = 69/161 (42%), Gaps = 3/161 (1%)
Query: 11 EEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPS 70
E+ ++ Q ++ + E+ E++ Q+Q Q+E+ G + KQE + +
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241
Query: 71 EAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDS 130
+ + +E + R ++ Q E + + E + + EQE++ G + +
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQ 301
Query: 131 DEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQ 171
+E E+ +E E+ +++ G +EEQ QK Q
Sbjct: 302 EEQMREQEEQMRE---QEEQMREQEEQMGKQEEQMWEQKEQ 339
Score = 31.6 bits (70), Expect = 1.1
Identities = 31/165 (18%), Positives = 71/165 (43%), Gaps = 7/165 (4%)
Query: 12 EREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSE 71
++EE + + E EE+ + ++ Q E++ Q Q+E+ + +QE + + +
Sbjct: 259 KQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQ 318
Query: 72 APELDEDEGFGD---WSQRPEQRQQHEGA-QGALDSGEPPQCRSPEGEQEDRPGLHAYEK 127
E +E G + W Q+ + +Q E + GE + + EQ + ++
Sbjct: 319 MREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQ 378
Query: 128 EDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQ 172
E+ E++ +E G + ++ +G + ++E Q +Q
Sbjct: 379 EEQMRKQEEQMRKQEEQMGEQ---KEQMGEQKEQMREQEEQMGEQ 420
Score = 29.3 bits (64), Expect = 5.3
Identities = 18/85 (21%), Positives = 40/85 (47%), Gaps = 4/85 (4%)
Query: 11 EEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPS 70
E++E++ Q ++E+ E+ +++ Q++ Q+E+ + KQE + +
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEE 394
Query: 71 EAPELDEDEGFGDWSQRPEQRQQHE 95
+ E E G Q+ + R+Q E
Sbjct: 395 QMGEQKEQMG----EQKEQMREQEE 415
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 42.0 bits (97), Expect = 8e-04
Identities = 51/199 (25%), Positives = 81/199 (40%), Gaps = 33/199 (16%)
Query: 2 AEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQ 61
A+ +PG +E + + +E EE+ E+ Q E R L+ +E ++ +
Sbjct: 731 AKGVEEPGGDEYTD----EKEKEIEREEDEQREEAQVEAGRDLEQGAQE------DQVAE 780
Query: 62 EMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPG 121
E ++ EA + EDE G ++ HE + D G+ RSPE E G
Sbjct: 781 EKWEVVQKQEAEGVREDEDKGQ-----REKGYHEARK---DQGDGEDSRSPEAATEGGAG 832
Query: 122 LHAYEKEDSD----------EVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQ 171
+ E+E D +LEE +LS EG G +++ + G E +
Sbjct: 833 EVSKERESGDGEAEGDQRAGGYYLEEDTLS-EGSGVA-SLEVDCAKEGNPHSSEMEEVAP 890
Query: 172 QPRTPSPLVLEGTIEQSSP 190
QP P + EG Q SP
Sbjct: 891 QPPQPEEMEPEG---QPSP 906
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 41.6 bits (96), Expect = 0.001
Identities = 44/187 (23%), Positives = 79/187 (42%), Gaps = 16/187 (8%)
Query: 24 SVEDEEEAVHEQCQHERDRQLQAQDEEGG----GHVPERP-KQEMLLSLKP-SEAPELDE 77
S++D+ +++ E C + + ++ D G V + P +E + +P E E +
Sbjct: 299 SIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSD 358
Query: 78 DEG-FGDWSQRPEQRQQHEGAQG---ALDSGEPPQCRSPE---GEQEDRPGLHAYEKEDS 130
EG + ++ P++ + EG + + S E PQ S G D A + E
Sbjct: 359 SEGSHNEEAKEPDKTNKKEGEKTDRVGVASEETPQTSSSSARPGTPSDHQSQEASQFERK 418
Query: 131 DEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQ--PRTPSP-LVLEGTIEQ 187
DE E+ ++E E+++ + + G E + Q Q T SP L+L +
Sbjct: 419 DEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPN 478
Query: 188 SSPPLSP 194
SP L P
Sbjct: 479 PSPTLRP 485
Score = 28.9 bits (63), Expect = 6.9
Identities = 36/152 (23%), Positives = 63/152 (41%), Gaps = 17/152 (11%)
Query: 25 VEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDW 84
+E + A EQ + E + + + ++EE R +QE +L + E + E+E
Sbjct: 750 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARR 809
Query: 85 SQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYE--KEDSDEVHLEELSLSK 142
Q R+Q E + AL + R E Q+ L E + + +E +E L K
Sbjct: 810 KQEEALRRQRE-QEIAL-----RRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 863
Query: 143 EGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPR 174
Q+ A A EE+E ++ ++ R
Sbjct: 864 ---------QEEEAAKWAREEEEAQRRLEENR 886
>gi|110347429 mediator complex subunit 12 [Homo sapiens]
Length = 2177
Score = 41.6 bits (96), Expect = 0.001
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 26 EDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWS 85
E +++ +Q Q ++ +Q Q Q ++ H+ ++ +Q++L + + + + +
Sbjct: 2050 EQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQ----Q 2105
Query: 86 QRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEEL--SLSKE 143
Q+ +Q+QQ + Q PPQ + Q R GL +++ + +L LS
Sbjct: 2106 QQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNT 2165
Query: 144 GPGPEDTV 151
P P +
Sbjct: 2166 QPQPSTNI 2173
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 40.4 bits (93), Expect = 0.002
Identities = 50/184 (27%), Positives = 71/184 (38%), Gaps = 44/184 (23%)
Query: 11 EEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPS 70
EE +E L W++E+ E+ E R L+ ++ G G QE L SL+
Sbjct: 886 EENQESLRSLGAWNLENLRSP--EEVDKESQRNLEEEENLGKGEY-----QESLRSLE-E 937
Query: 71 EAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDS 130
E EL + W E+ Q E QE PG+ E ED
Sbjct: 938 EGQELPQSADVQRWEDTVEKDQ--------------------ELAQESPPGMAGVENEDE 977
Query: 131 DEVHLEELSLSKEG-PGPEDTVQDNLGAAGAEEE----QEEHQKCQQPRTPSPLVLEGTI 185
E++L E ++G G E+ V+ G A EE E H P +P P G +
Sbjct: 978 AELNLRE----QDGFTGKEEVVEQ--GELNATEEVWIPGEGH-----PESPEPKEQRGLV 1026
Query: 186 EQSS 189
E +S
Sbjct: 1027 EGAS 1030
Score = 37.0 bits (84), Expect = 0.025
Identities = 52/206 (25%), Positives = 78/206 (37%), Gaps = 32/206 (15%)
Query: 7 DPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGG----------GHVP 56
DP E L P ++ ++E E E+C RD L + E+ G G V
Sbjct: 1333 DPAVLASEGLEAPPSE---KEEGEEGEEECG--RDSDLSEEFEDLGTEAPFLPGVPGEVA 1387
Query: 57 ERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCR----SP 112
E Q L L P+ E +GF D E+ EG + + EP R S
Sbjct: 1388 EPLGQVPQLLLDPAAWDRDGESDGFAD-----EEESGEEGEEDQEEGREPGAGRWGPGSS 1442
Query: 113 EGEQEDRPGLHAYEKEDSDEVHLE---ELSLSKEGPGPEDTV-----QDNLGAAGAEEEQ 164
G + E +SD V + + SL G T QD+ +G+EEE
Sbjct: 1443 VGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEEES 1502
Query: 165 EEHQKCQQPRTPSPLVLEGTIEQSSP 190
+ ++ + P PL + +E + P
Sbjct: 1503 DPVSLEREDKVPGPLEIPSGMEDAGP 1528
Score = 36.2 bits (82), Expect = 0.043
Identities = 66/332 (19%), Positives = 124/332 (37%), Gaps = 38/332 (11%)
Query: 11 EEREEL--LGPTAQW--SVEDEEEAVHEQ------CQHERDRQLQAQDEEGGGHVPERPK 60
EE +EL +W +VE ++E E ++E + +L ++++G E +
Sbjct: 937 EEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVE 996
Query: 61 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQED-- 118
Q L + + P E PE ++Q +GA G + PEG+ +
Sbjct: 997 QGELNATEEVWIPGEGHPES-------PEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVG 1049
Query: 119 RPGLHAYE--KEDSDEVHLEELSLSKEGPGPEDTV--QDNLGAAGAEEEQEEHQKCQQPR 174
PGL A + E + + ++++ + PE + + +G + A E Q
Sbjct: 1050 APGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLG 1109
Query: 175 TPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQY 234
P L E +E S K + E + +E++ + +LP D W
Sbjct: 1110 DPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPR 1169
Query: 235 TQAIETAGRTPKLARQA-SIELPSMAVASTKSRWETGEVQAQ----------SAAKTPSC 283
E+ P+ A +A E + S W G +A+ S TP
Sbjct: 1170 EGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPIL 1229
Query: 284 KDIVA----GDMSKKSLWEQKGGSKTSSTIKS 311
+D + S+++ W +G ++ ++S
Sbjct: 1230 EDAPGPQPQAEGSQEASWGVQGRAEALGKVES 1261
Score = 35.4 bits (80), Expect = 0.073
Identities = 47/172 (27%), Positives = 66/172 (38%), Gaps = 40/172 (23%)
Query: 8 PGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSL 67
P AE +E A W V+ EA+ + Q+E G G +PE P++E S
Sbjct: 1237 PQAEGSQE-----ASWGVQGRAEAL--------GKVESEQEELGSGEIPEGPQEEGEESR 1283
Query: 68 KPSEAPELDE------DEGF-------GDWSQRPEQRQQHEGAQG---------ALDSGE 105
+ SE EL E GF W EQR +G G A + E
Sbjct: 1284 EESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLE 1343
Query: 106 PPQCRSPEGEQ-EDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLG 156
P EGE+ E+ G + E+ +++ E L PG V + LG
Sbjct: 1344 APPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFL----PGVPGEVAEPLG 1391
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 40.4 bits (93), Expect = 0.002
Identities = 73/346 (21%), Positives = 126/346 (36%), Gaps = 50/346 (14%)
Query: 1 MAEASSDPGAEERE------ELLGPTAQWSVEDEEEAVHEQCQ-------HERDRQLQAQ 47
+ EA D A+ERE E + E E E + E+ + HE + LQ +
Sbjct: 1760 LGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDN--LQGE 1817
Query: 48 DEEGGGHVP---------ERPKQEMLLSLKPS--EAPELDEDEGFGDWSQRPEQRQQHEG 96
GG P E P+ E + EAPE + D + +PE
Sbjct: 1818 AAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAP 1877
Query: 97 AQGALDSGEPPQCRSPEGEQEDRP---GLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQD 153
E +PE E E +P G A E E + E + + E G ++ +
Sbjct: 1878 EAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVE-ALETEGEDEPESE 1936
Query: 154 NLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKL----IDRTESLNRSI 209
A AEE +E + QP S ++ E+ + P S + ++ E+ +
Sbjct: 1937 GAEAQEAEEAAQEAEGQTQPE--SEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQ 1994
Query: 210 EKSNSVKKSQPDLPISKIDQWLE------------QYTQAIETAGRTPKLARQASIELPS 257
+S V+ + + + + ++ + + +A E G T K A E
Sbjct: 1995 PESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG 2054
Query: 258 MAV--ASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKG 301
+ A +++ GEVQ P +D+ A + ++ E +G
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
Score = 36.6 bits (83), Expect = 0.033
Identities = 26/126 (20%), Positives = 55/126 (43%)
Query: 38 HERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGA 97
+E + + ++++ ++ + + + ++ E E E EG + + + E+ + EG
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331
Query: 98 QGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGA 157
Q E + EG+QE+ L E+ + + E + L + GPE +Q
Sbjct: 1332 QEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
Query: 158 AGAEEE 163
G +EE
Sbjct: 1392 EGLKEE 1397
Score = 35.0 bits (79), Expect = 0.096
Identities = 50/200 (25%), Positives = 76/200 (38%), Gaps = 35/200 (17%)
Query: 3 EASSDPGAEEREELLGPT--AQWSVEDEEEAVH--EQCQHERDRQLQAQDEEGGGHVPER 58
EA EE +E+ G T + + E + V E + ++ + + Q+ EG H PE
Sbjct: 2024 EAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAH-PES 2082
Query: 59 PK---QEMLLSLKPS----EAPELDED----EGFGDWSQRPEQRQQHEGAQGALDSGEPP 107
QE +P EAPE + + EG E + + EG + GE
Sbjct: 2083 EDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQ 2142
Query: 108 ------QCRSPEGE-QEDRPGLHAYEKEDSDEVHLEELSLSK------------EGPGPE 148
+ + EGE Q + G+ A E E+ + LE + + E P E
Sbjct: 2143 PESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAE 2202
Query: 149 DTVQDNLGAAGAEEEQEEHQ 168
Q L A E +EE Q
Sbjct: 2203 GEAQPELEGVEAPEAEEEAQ 2222
>gi|92087055 PERQ amino acid rich, with GYF domain 1 [Homo sapiens]
Length = 1035
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/152 (24%), Positives = 62/152 (40%), Gaps = 28/152 (18%)
Query: 42 RQLQAQDEEGGGHVPERPKQE--MLLSLKPSEAPELDEDEGFGDWSQRPEQRQQ------ 93
R+ Q ++EEG + P+++ S P P W + E+R++
Sbjct: 202 REEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRS------AGWREHGERRRKFEFDLR 255
Query: 94 -------HEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLS----- 141
E +G S +CR+PEG +ED+ GL + +D DE + S
Sbjct: 256 GDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDEDE-EMGTFDASGAFLP 314
Query: 142 -KEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQ 172
K+GP + L G EEE+E + ++
Sbjct: 315 LKKGPKEPIPEEQELDFQGLEEEEEPSEGLEE 346
>gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Homo
sapiens]
Length = 1108
Score = 40.0 bits (92), Expect = 0.003
Identities = 26/140 (18%), Positives = 55/140 (39%), Gaps = 3/140 (2%)
Query: 33 HEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQ 92
+ C+ E + + + EE G PE E + + + DE E +++
Sbjct: 967 YSYCKREAEERDSTEQEEAG---PEILSNEHVGARASPSQGDSDERESLTREEDEDSEKE 1023
Query: 93 QHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQ 152
+ E + + E +C P+G++E+ E+E+ +E E EG +D +
Sbjct: 1024 EEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAE 1083
Query: 153 DNLGAAGAEEEQEEHQKCQQ 172
+ G + + Q ++
Sbjct: 1084 SQASSLGQKVGESSEQVSEE 1103
>gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Homo
sapiens]
Length = 1124
Score = 40.0 bits (92), Expect = 0.003
Identities = 26/140 (18%), Positives = 55/140 (39%), Gaps = 3/140 (2%)
Query: 33 HEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQ 92
+ C+ E + + + EE G PE E + + + DE E +++
Sbjct: 983 YSYCKREAEERDSTEQEEAG---PEILSNEHVGARASPSQGDSDERESLTREEDEDSEKE 1039
Query: 93 QHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQ 152
+ E + + E +C P+G++E+ E+E+ +E E EG +D +
Sbjct: 1040 EEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAE 1099
Query: 153 DNLGAAGAEEEQEEHQKCQQ 172
+ G + + Q ++
Sbjct: 1100 SQASSLGQKVGESSEQVSEE 1119
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
sapiens]
Length = 1341
Score = 39.7 bits (91), Expect = 0.004
Identities = 47/195 (24%), Positives = 74/195 (37%), Gaps = 20/195 (10%)
Query: 10 AEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKP 69
AEE E+ P+ V + E+ + E + + + +EE G ++ ++ +L
Sbjct: 246 AEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFK 305
Query: 70 SEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKED 129
E E+ + +RP+ R Q Q L+ G RS E ++ EKE
Sbjct: 306 EEGEEIPRVKPEEMMDERPKTRSQE---QEVLERG-GRFTRSQEEARKSHLARQQQEKEM 361
Query: 130 SDEVHLEE----------LSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPL 179
LEE L + P P +D A+ + Q + TP PL
Sbjct: 362 KTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPE---QTASEEETPPPL 418
Query: 180 VLEGTIEQSSPPLSP 194
+ T E SSPP P
Sbjct: 419 L---TKEASSPPPHP 430
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.124 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,426,931
Number of Sequences: 37866
Number of extensions: 907219
Number of successful extensions: 4160
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 418
Number of HSP's that attempted gapping in prelim test: 3276
Number of HSP's gapped (non-prelim): 1018
length of query: 339
length of database: 18,247,518
effective HSP length: 103
effective length of query: 236
effective length of database: 14,347,320
effective search space: 3385967520
effective search space used: 3385967520
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.