Search of human proteins with 4557515

Search of human proteins with 4557515

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557515 damage-specific DNA binding protein 2 [Homo sapiens]
         (427 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557515 damage-specific DNA binding protein 2 [Homo sapiens]       891   0.0  
gi|4557467 excision repair cross-complementing rodent repair def...    62   8e-10
gi|13376367 WD repeat domain 76 [Homo sapiens]                         55   9e-08
gi|26665869 WD repeat domain 51B [Homo sapiens]                        54   2e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     51   2e-06
gi|13376840 WD repeat domain 61 [Homo sapiens]                         51   2e-06
gi|8922301 WD repeat domain 70 [Homo sapiens]                          49   7e-06
gi|168229161 coronin 7 [Homo sapiens]                                  46   6e-05
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             46   7e-05
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             46   7e-05
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    45   1e-04
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             44   2e-04
gi|4757988 WD repeat domain 39 [Homo sapiens]                          44   2e-04
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]    44   3e-04
gi|113865883 WD repeat domain 38 [Homo sapiens]                        43   5e-04
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       43   6e-04
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     42   8e-04
gi|55741849 WD repeat domain 22 [Homo sapiens]                         42   0.001
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     42   0.001
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    42   0.001
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          42   0.001
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          42   0.001
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          42   0.001
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            42   0.001
gi|16554629 WD repeat domain 5 [Homo sapiens]                          42   0.001
gi|16554627 WD repeat domain 5 [Homo sapiens]                          42   0.001
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ...    41   0.002
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     41   0.002
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     41   0.002
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     41   0.002

>gi|4557515 damage-specific DNA binding protein 2 [Homo sapiens]
          Length = 427

 Score =  891 bits (2302), Expect = 0.0
 Identities = 427/427 (100%), Positives = 427/427 (100%)

Query: 1   MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGP 60
           MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGP
Sbjct: 1   MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGP 60

Query: 61  QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWH 120
           QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWH
Sbjct: 61  QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWH 120

Query: 121 PTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGT 180
           PTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGT
Sbjct: 121 PTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGT 180

Query: 181 TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM 240
           TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM
Sbjct: 181 TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM 240

Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300
           HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG
Sbjct: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300

Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN 360
           ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN
Sbjct: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN 360

Query: 361 FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ 420
           FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ
Sbjct: 361 FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ 420

Query: 421 EEARTRK 427
           EEARTRK
Sbjct: 421 EEARTRK 427


>gi|4557467 excision repair cross-complementing rodent repair
           deficiency, complementation group 8 isoform 1 [Homo
           sapiens]
          Length = 396

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 51/178 (28%), Positives = 86/178 (48%), Gaps = 20/178 (11%)

Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR---VFASSDTINIWFCSLDVSASSR 214
           S+  +++ P +T  F +SS + T ++ D   N L+   VF   +T+     S  VS    
Sbjct: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDT--NTLQTADVFNFEETVYSHHMS-PVSTKHC 157

Query: 215 MVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273
           +V  G     V L ++  G     L+ H++++  V+ +P  D+ LATAS D  VK+WD+R
Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217

Query: 274 QVRG-------------KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 318
           +  G             +A    +  H   VN  CF+ DG  LLT    + +R++++S
Sbjct: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275


>gi|13376367 WD repeat domain 76 [Homo sapiens]
          Length = 626

 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 75/308 (24%), Positives = 133/308 (43%), Gaps = 31/308 (10%)

Query: 116 SLAWHPTHPST-VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS-ITGLKFNPLNTNQFY 173
           S+A HP+   T VAVG+K G + L +   + K   +         ++ L F+P N     
Sbjct: 318 SMALHPSETRTLVAVGAKFGQVGLCDLTQQPKEDGVYVFHPHSQPVSCLYFSPANPAHIL 377

Query: 174 ASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLD-VSASSRMVVTGDNVGNVILLN--- 229
           + S +GT R  DF   I      ++  +  F S D ++  +  ++ G   GN+ L++   
Sbjct: 378 SLSYDGTLRCGDFSRAIFEEVYRNERSS--FSSFDFLAEDASTLIVGHWDGNMSLVDRRT 435

Query: 230 --MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS--FLYSL 285
                ++L +  M K +  HV  +P    +  TA +  T  I+D R++  + S   +   
Sbjct: 436 PGTSYEKLTSSSMGKIRTVHV--HPVHRQYFITAGLRDT-HIYDARRLNSRRSQPLISLT 492

Query: 286 PHRHPVNAACFSP-DGARLLTTDQKSEIRVYSASQWDCPLGL---IPHPHRHFQHLTPIK 341
            H   + +A FSP  G R++TT     +R++ +S     + L   I H     + LT  +
Sbjct: 493 EHTKSIASAYFSPLTGNRVVTTCADCNLRIFDSSCISSKIPLLTTIRHNTFTGRWLTRFQ 552

Query: 342 AAWHPRY-NLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400
           A W P+  + ++VG    P          R +++F   +GK +          + S+N  
Sbjct: 553 AMWDPKQEDCVIVGSMAHP----------RRVEIFH-ETGKRVHSFGGEYLVSVCSINAM 601

Query: 401 NPMGDTLA 408
           +P    LA
Sbjct: 602 HPTRYILA 609


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 61/206 (29%), Positives = 93/206 (45%), Gaps = 25/206 (12%)

Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGK-ELWNLRMHKKKVTHVALNPCCDWFLATASVD 264
           SLD+S + + + T      ++L N       +    HK  VT V  +P  +  LA+AS D
Sbjct: 23  SLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN-LLASASRD 81

Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPL 324
           +TV++W +   RGK S   +  H  PV +  FS DG  L T  +   I+V+S  +     
Sbjct: 82  RTVRLW-IPDKRGKFSEFKA--HTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLY 138

Query: 325 GLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMC 384
            L  H H          A + P   LIV          SC+  E +TI ++D  + + + 
Sbjct: 139 SLYRHTH------WVRCAKFSPDGRLIV----------SCS--EDKTIKIWDTTNKQCVN 180

Query: 385 QLYDPESSGISSLNEFNPMGDTLASA 410
              D  S G ++  +FNP G  +ASA
Sbjct: 181 NFSD--SVGFANFVDFNPSGTCIASA 204



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 47/173 (27%), Positives = 76/173 (43%), Gaps = 14/173 (8%)

Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK--GNILRVFASSDTINIWFCSLDVSA 211
           G   +IT L  +P N  Q   +S +    L +FK      R     D +     S+  S 
Sbjct: 16  GHKAAITSLDLSP-NGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT----SVQFSP 70

Query: 212 SSRMVVTGDNVGNVILLNMDGKELWN-LRMHKKKVTHVALNPCCDWFLATASVDQTVKIW 270
              ++ +      V L   D +  ++  + H   V  V  +     FLATAS D+++K+W
Sbjct: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFS-ADGQFLATASEDKSIKVW 129

Query: 271 DLRQVRGKASFLYSL-PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322
            + + R    FLYSL  H H V  A FSPDG  +++  +   I+++  +   C
Sbjct: 130 SMYRQR----FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 56/244 (22%), Positives = 92/244 (37%), Gaps = 55/244 (22%)

Query: 115 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174
           TSL   P +   +A  S    +MLWNF  K      + +G    +T ++F+P + N   +
Sbjct: 22  TSLDLSP-NGKQLATASWDTFLMLWNF--KPHARAYRYVGHKDVVTSVQFSP-HGNLLAS 77

Query: 175 SSMEGTTRL--QDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG 232
           +S + T RL   D +G      A +  +     S+D SA  + + T     ++ + +M  
Sbjct: 78  ASRDRTVRLWIPDKRGKFSEFKAHTAPVR----SVDFSADGQFLATASEDKSIKVWSMYR 133

Query: 233 KE-LWNLRMHKKKVTHVALNP-----------------------CCDWF----------- 257
           +  L++L  H   V     +P                       C + F           
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD 193

Query: 258 -------LATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
                  +A+A  DQTVK+WD   VR      +   H   VN   F P G  L+T     
Sbjct: 194 FNPSGTCIASAGSDQTVKVWD---VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250

Query: 311 EIRV 314
            +++
Sbjct: 251 TLKI 254



 Score = 30.0 bits (66), Expect = 4.2
 Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 6/69 (8%)

Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPV 291
           K L + ++H   V  ++ +P  + +L TAS D T+KI DL + R     +Y+L  H  PV
Sbjct: 219 KLLQHYQVHSGGVNCISFHPSGN-YLITASSDGTLKILDLLEGR----LIYTLQGHTGPV 273

Query: 292 NAACFSPDG 300
               FS  G
Sbjct: 274 FTVSFSKGG 282


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 61/224 (27%), Positives = 95/224 (42%), Gaps = 27/224 (12%)

Query: 115 TSLAW-------HPTHPSTVAVG-------SKGGDIMLWNFGIKDKPTFIKGIGAGGSIT 160
           T  AW       H ++ S++ +G       + GGD    N    +KP  I  +   G  +
Sbjct: 7   TKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT--GHTS 64

Query: 161 GLKFNPLNTNQ--FYASSMEGTTRLQDFKG-NILRVFASSDTINIWFCSLDVSASSRMVV 217
            ++   LNT +    A S  G+ R+ D +   ILR        NI  CSLD       V 
Sbjct: 65  PVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA-NI--CSLDFHPYGEFVA 121

Query: 218 TGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276
           +G    N+ L ++  K  ++  R H + V  +  +P   W LA+A+ D TVK+WDL   +
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW-LASAADDHTVKLWDLTAGK 180

Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQW 320
             + F     H  PVN   F P+   L +      IR +   ++
Sbjct: 181 MMSEF---PGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKF 221



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 53/198 (26%), Positives = 88/198 (44%), Gaps = 17/198 (8%)

Query: 122 THPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTT 181
           T    +  GS+ G I +W+  ++        +G   +I  L F+P    +F AS  + T 
Sbjct: 73  TPEELIVAGSQSGSIRVWD--LEAAKILRTLMGHKANICSLDFHPYG--EFVASGSQDTN 128

Query: 182 -RLQDF--KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-GKELWN 237
            +L D   KG + R    S  +      L  S   + + +  +   V L ++  GK +  
Sbjct: 129 IKLWDIRRKGCVFRYRGHSQAVRC----LRFSPDGKWLASAADDHTVKLWDLTAGKMMSE 184

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFS 297
              H   V  V  +P  ++ LA+ S D+T++ WDL + +   S +   P   PV +  F+
Sbjct: 185 FPGHTGPVNVVEFHPN-EYLLASGSSDRTIRFWDLEKFQ-VVSCIEGEPG--PVRSVLFN 240

Query: 298 PDGARLLTTDQKSEIRVY 315
           PDG  L +  Q S +RVY
Sbjct: 241 PDGCCLYSGCQDS-LRVY 257


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 49/206 (23%), Positives = 95/206 (46%), Gaps = 15/206 (7%)

Query: 116 SLAWHPT---HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQF 172
           S+AW      +  TV  GS    + +W +  +D+   ++    G  +  +  +  +T   
Sbjct: 21  SVAWGTNKKENSETVVTGSLDDLVKVWKW--RDERLDLQWSLEGHQLGVVSVDISHTLPI 78

Query: 173 YASS-MEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD 231
            ASS ++   RL D +         +  ++ W  +L  S  S+ + TG +VG V +  ++
Sbjct: 79  AASSSLDAHIRLWDLENGKQIKSIDAGPVDAW--TLAFSPDSQYLATGTHVGKVNIFGVE 136

Query: 232 -GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRH 289
            GK+ ++L    K +  +A +P    +LA+ ++D  + I+D+         L++L  H  
Sbjct: 137 SGKKEYSLDTRGKFILSIAYSPDGK-YLASGAIDGIINIFDI----ATGKLLHTLEGHAM 191

Query: 290 PVNAACFSPDGARLLTTDQKSEIRVY 315
           P+ +  FSPD   L+T      I++Y
Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIY 217



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 12/121 (9%)

Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLATASVD 264
           SL  S  S+++VT  + G + + ++    L   L  H   V +VA  P    F++++S D
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS-D 253

Query: 265 QTVKIWDLRQVRGKASFLYS-LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCP 323
           ++VK+WD+    G  + +++   H+  V    ++ +G+++++     EI +Y     DCP
Sbjct: 254 KSVKVWDV----GTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY-----DCP 304

Query: 324 L 324
           +
Sbjct: 305 I 305


>gi|8922301 WD repeat domain 70 [Homo sapiens]
          Length = 654

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 58/265 (21%), Positives = 89/265 (33%), Gaps = 74/265 (27%)

Query: 118 AWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSM 177
           +WHP         S    +  W     + P   K +    ++ G K  P           
Sbjct: 290 SWHPKIKGEFMTCSNDATVRTWEV---ENPKKQKSVFKPRTMQGKKVIP----------- 335

Query: 178 EGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWN 237
             TT      GN++     + +I IW  +L V                            
Sbjct: 336 --TTCTYSRDGNLIAAACQNGSIQIWDRNLTVHP-------------------------- 367

Query: 238 LRMHKKKVTHVALNPCCDWF------LATASVDQTVKIWDLRQVRGKASFLYSLPHRHPV 291
            + H K+      +  C  F      LA+   D ++K+WD+RQ          LP   P+
Sbjct: 368 -KFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMFPM 426

Query: 292 NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLG-LIPHPHRHFQHL--------TPIKA 342
              CFSPD   ++T          ++ Q  C  G L+    R FQ +        + ++ 
Sbjct: 427 TDCCFSPDDKLIVTG---------TSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRC 477

Query: 343 AWHPRYNLIVVGR-------YPDPN 360
            WHP+ N I+VG        Y DPN
Sbjct: 478 LWHPKLNQIMVGTGNGLAKVYYDPN 502


>gi|168229161 coronin 7 [Homo sapiens]
          Length = 925

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300
           H +K+  +  +P     LA++S D TV+IWDL   +  A  L    H+  + +  +SPDG
Sbjct: 593 HTEKICSLRFHPLAANVLASSSYDLTVRIWDL---QAGADRLKLQGHQDQIFSLAWSPDG 649

Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330
            +L T  +   +RVY       PL   P P
Sbjct: 650 QQLATVCKDGRVRVYRPRSGPEPLQEGPGP 679



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 3/92 (3%)

Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL---RQVRGKASFLYSLPH 287
           D + + +L  H   VT +  +P  D+ LAT S D+TVK+W L    Q    A  +   P 
Sbjct: 66  DKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPE 125

Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319
             PV    F P    +L +   + ++V+ A++
Sbjct: 126 DLPVEVLQFHPTSDGILVSAAGTTVKVWDAAK 157



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 34/122 (27%), Positives = 54/122 (44%), Gaps = 8/122 (6%)

Query: 80  RASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRA---TSLAWHPTHPSTVAVGSKGGDI 136
           R + P +  G Q + L      R+   A P  +     T LAW P  P  +AV  +   I
Sbjct: 510 RVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARI 569

Query: 137 MLWNF---GIKDKPTFIKGIGAGGS--ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL 191
            LW     G+++  T  + +  G +  I  L+F+PL  N   +SS + T R+ D +    
Sbjct: 570 RLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGAD 629

Query: 192 RV 193
           R+
Sbjct: 630 RL 631


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 63/264 (23%), Positives = 112/264 (42%), Gaps = 40/264 (15%)

Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK--GNILRVFASSDTINIWFCSLDVSA 211
           G   ++T + F+ +NT Q  + SM+    +   K      R     D +      ++ S 
Sbjct: 17  GHRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC----VNFSP 71

Query: 212 SSRMVVTG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDW-FLATASVDQTVK 268
           S  ++ +G  D    + + N+ G E    R H   V  V    C D     TAS D+TVK
Sbjct: 72  SGHLLASGSRDKTVRIWVPNVKG-ESTVFRAHTATVRSVHF--CSDGQSFVTASDDKTVK 128

Query: 269 IWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327
           +W   + +    FL+SL  H + V  A FSPDG  +++      ++++  S  +C     
Sbjct: 129 VWATHRQK----FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC----- 179

Query: 328 PHPHRHFQHLTPIK-AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQL 386
              H + +H   +    +HP    I      +            T+ V+D  + +++ Q 
Sbjct: 180 --VHSYCEHGGFVTYVDFHPSGTCIAAAGMDN------------TVKVWDVRTHRLL-QH 224

Query: 387 YDPESSGISSLNEFNPMGDTLASA 410
           Y   S+ ++ L+ F+P G+ L +A
Sbjct: 225 YQLHSAAVNGLS-FHPSGNYLITA 247



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 48/194 (24%), Positives = 84/194 (43%), Gaps = 20/194 (10%)

Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRL--- 183
           +A GS+   + +W   +K + T  +   A  ++  + F   +   F  +S + T ++   
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTA--TVRSVHFCS-DGQSFVTASDDKTVKVWAT 132

Query: 184 --QDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE-LWNLRM 240
             Q F      +F+ S  IN W      S   R++V+  +   V L +   +E + +   
Sbjct: 133 HRQKF------LFSLSQHIN-WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185

Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300
           H   VT+V  +P     +A A +D TVK+WD+R  R    +     H   VN   F P G
Sbjct: 186 HGGFVTYVDFHPS-GTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAAVNGLSFHPSG 241

Query: 301 ARLLTTDQKSEIRV 314
             L+T    S +++
Sbjct: 242 NYLITASSDSTLKI 255



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 6/85 (7%)

Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNA 293
           L + ++H   V  ++ +P  + +L TAS D T+KI DL + R     LY+L  H+ P   
Sbjct: 222 LQHYQLHSAAVNGLSFHPSGN-YLITASSDSTLKILDLMEGR----LLYTLHGHQGPATT 276

Query: 294 ACFSPDGARLLTTDQKSEIRVYSAS 318
             FS  G    +     ++ V+ ++
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKSN 301


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 63/264 (23%), Positives = 112/264 (42%), Gaps = 40/264 (15%)

Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK--GNILRVFASSDTINIWFCSLDVSA 211
           G   ++T + F+ +NT Q  + SM+    +   K      R     D +      ++ S 
Sbjct: 17  GHRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC----VNFSP 71

Query: 212 SSRMVVTG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDW-FLATASVDQTVK 268
           S  ++ +G  D    + + N+ G E    R H   V  V    C D     TAS D+TVK
Sbjct: 72  SGHLLASGSRDKTVRIWVPNVKG-ESTVFRAHTATVRSVHF--CSDGQSFVTASDDKTVK 128

Query: 269 IWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327
           +W   + +    FL+SL  H + V  A FSPDG  +++      ++++  S  +C     
Sbjct: 129 VWATHRQK----FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC----- 179

Query: 328 PHPHRHFQHLTPIK-AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQL 386
              H + +H   +    +HP    I      +            T+ V+D  + +++ Q 
Sbjct: 180 --VHSYCEHGGFVTYVDFHPSGTCIAAAGMDN------------TVKVWDVRTHRLL-QH 224

Query: 387 YDPESSGISSLNEFNPMGDTLASA 410
           Y   S+ ++ L+ F+P G+ L +A
Sbjct: 225 YQLHSAAVNGLS-FHPSGNYLITA 247



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 48/194 (24%), Positives = 84/194 (43%), Gaps = 20/194 (10%)

Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRL--- 183
           +A GS+   + +W   +K + T  +   A  ++  + F   +   F  +S + T ++   
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTA--TVRSVHFCS-DGQSFVTASDDKTVKVWAT 132

Query: 184 --QDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE-LWNLRM 240
             Q F      +F+ S  IN W      S   R++V+  +   V L +   +E + +   
Sbjct: 133 HRQKF------LFSLSQHIN-WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185

Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300
           H   VT+V  +P     +A A +D TVK+WD+R  R    +     H   VN   F P G
Sbjct: 186 HGGFVTYVDFHPS-GTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAAVNGLSFHPSG 241

Query: 301 ARLLTTDQKSEIRV 314
             L+T    S +++
Sbjct: 242 NYLITASSDSTLKI 255



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 6/85 (7%)

Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNA 293
           L + ++H   V  ++ +P  + +L TAS D T+KI DL + R     LY+L  H+ P   
Sbjct: 222 LQHYQLHSAAVNGLSFHPSGN-YLITASSDSTLKILDLMEGR----LLYTLHGHQGPATT 276

Query: 294 ACFSPDGARLLTTDQKSEIRVYSAS 318
             FS  G    +     ++ V+ ++
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKSN 301


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 34/136 (25%), Positives = 61/136 (44%), Gaps = 3/136 (2%)

Query: 197 SDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCD 255
           S  +NI +          ++ TG N G + + ++  GK L NL  H + V  +   P   
Sbjct: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183

Query: 256 WFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315
             L +AS D+T+++WDL+        L    H++ V +  FSPD + L +      + ++
Sbjct: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRG--HQNWVYSCAFSPDSSMLCSVGASKAVFLW 241

Query: 316 SASQWDCPLGLIPHPH 331
           +  ++     L  H H
Sbjct: 242 NMDKYTMIRKLEGHHH 257


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 48/194 (24%), Positives = 84/194 (43%), Gaps = 20/194 (10%)

Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRL--- 183
           +A GS+   + +W   +K + T  +   A  ++  + F   +   F  +S + T ++   
Sbjct: 38  LASGSRDKTVRIWVPNVKGESTVFRAHTA--TVRSVHFCS-DGQSFVTASDDKTVKVWAT 94

Query: 184 --QDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE-LWNLRM 240
             Q F      +F+ S  IN W      S   R++V+  +   V L +   +E + +   
Sbjct: 95  HRQKF------LFSLSQHIN-WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 147

Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300
           H   VT+V  +P     +A A +D TVK+WD+R  R    +     H   VN   F P G
Sbjct: 148 HGGFVTYVDFHPS-GTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAAVNGLSFHPSG 203

Query: 301 ARLLTTDQKSEIRV 314
             L+T    S +++
Sbjct: 204 NYLITASSDSTLKI 217



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 52/209 (24%), Positives = 92/209 (44%), Gaps = 33/209 (15%)

Query: 207 LDVSASSRMVVTG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDW-FLATASV 263
           ++ S S  ++ +G  D    + + N+ G E    R H   V  V    C D     TAS 
Sbjct: 29  VNFSPSGHLLASGSRDKTVRIWVPNVKG-ESTVFRAHTATVRSVHF--CSDGQSFVTASD 85

Query: 264 DQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322
           D+TVK+W   + +    FL+SL  H + V  A FSPDG  +++      ++++  S  +C
Sbjct: 86  DKTVKVWATHRQK----FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141

Query: 323 PLGLIPHPHRHFQHLTPIK-AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGK 381
                   H + +H   +    +HP    I      +            T+ V+D  + +
Sbjct: 142 -------VHSYCEHGGFVTYVDFHPSGTCIAAAGMDN------------TVKVWDVRTHR 182

Query: 382 MMCQLYDPESSGISSLNEFNPMGDTLASA 410
           ++ Q Y   S+ ++ L+ F+P G+ L +A
Sbjct: 183 LL-QHYQLHSAAVNGLS-FHPSGNYLITA 209



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 6/85 (7%)

Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNA 293
           L + ++H   V  ++ +P  + +L TAS D T+KI DL + R     LY+L  H+ P   
Sbjct: 184 LQHYQLHSAAVNGLSFHPSGN-YLITASSDSTLKILDLMEGR----LLYTLHGHQGPATT 238

Query: 294 ACFSPDGARLLTTDQKSEIRVYSAS 318
             FS  G    +     ++ V+ ++
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVWKSN 263


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 46/185 (24%), Positives = 76/185 (41%), Gaps = 26/185 (14%)

Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300
           H++ V  VA +PC + +LA+AS D T  IW   Q   +        H + V +  ++P G
Sbjct: 60  HQRTVRKVAWSPCGN-YLASASFDATTCIWKKNQDDFECVTTLE-GHENEVKSVAWAPSG 117

Query: 301 ARLLTTDQKSEIRVYSA---SQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYP 357
             L T  +   + V+      +++C   L  H  +  +H+      WHP   L+    Y 
Sbjct: 118 NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHT-QDVKHV-----VWHPSQELLASASYD 171

Query: 358 DPNFKSCTPYELRTIDVF-DGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH-I 415
           D            T+ ++ +     + C   +   S + SL  F+P G  LAS      +
Sbjct: 172 D------------TVKLYREEEDDWVCCATLEGHESTVWSL-AFDPSGQRLASCSDDRTV 218

Query: 416 LIWSQ 420
            IW Q
Sbjct: 219 RIWRQ 223


>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
          Length = 919

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 60/228 (26%), Positives = 88/228 (38%), Gaps = 15/228 (6%)

Query: 89  GLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPT 148
           GL Q  +    S   + K         +LA+ P     +  G   G + +WN        
Sbjct: 351 GLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDG-QYIVTGGDDGKVKVWN--TLSGFC 407

Query: 149 FIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSL 207
           F+        +TG+ F          SSM+GT R  D  +    R F S       F  +
Sbjct: 408 FVTFTEHSSGVTGVTFTATGY-VVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQ--FSCV 464

Query: 208 DVSASSRMVVTG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQ 265
            V AS  +V  G  D+    +     G+ L  L  H+  ++ +  NP     LA+AS D+
Sbjct: 465 AVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKS-VLASASWDK 523

Query: 266 TVKIWDL-RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEI 312
           TV++WD+    R K     +L       A  F PDGA L      S+I
Sbjct: 524 TVRLWDMFDSWRTKE----TLALTSDALAVTFRPDGAELAVATLNSQI 567



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 26/118 (22%), Positives = 51/118 (43%), Gaps = 4/118 (3%)

Query: 213 SRMVVTGDNVGNVILLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271
           S ++VTG   G   L  +    L  +L +  + +  VA+N   DW     S    + +W+
Sbjct: 300 SHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWE 359

Query: 272 LRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329
            +    ++  L    H + + A  +SPDG  ++T     +++V++     C +    H
Sbjct: 360 WQS---ESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEH 414


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 45/170 (26%), Positives = 73/170 (42%), Gaps = 26/170 (15%)

Query: 137 MLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFA 195
           +LW  G           G  G +   +F+P + + F ++S + T RL D  +   LRV  
Sbjct: 55  LLWRLG-----------GHTGPVKFCRFSP-DGHLFASASCDCTVRLWDVARAKCLRVLK 102

Query: 196 ----SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM-HKKKVTHVAL 250
               S +T++        S  SR + +G     V+L ++   ++  L + H+  +     
Sbjct: 103 GHQRSVETVSF-------SPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF 155

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300
           +P  +  LAT S D TV IWDLR V    S      H   ++  C+S  G
Sbjct: 156 SPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 3/78 (3%)

Query: 254 CDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIR 313
           C  F+A++S+D+T KIWD+   R + + LY   H   VN+  F P    LLT+     + 
Sbjct: 447 CGNFVASSSLDKTSKIWDVNSERCRCT-LYG--HTDSVNSIEFFPFSNTLLTSSADKTLS 503

Query: 314 VYSASQWDCPLGLIPHPH 331
           ++ A    C   L  H H
Sbjct: 504 IWDARTGICEQSLYGHMH 521



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 44/188 (23%), Positives = 77/188 (40%), Gaps = 28/188 (14%)

Query: 239 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP 298
           R+H+  V+ V++ P  D  L +   D+  K+  L +       L    H   ++  CF P
Sbjct: 349 RLHELPVSCVSMQPHKD-ILVSCGEDRLWKVLGLPKCN---VLLTGFGHTDWLSDCCFHP 404

Query: 299 DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 358
            G +L T+   + ++++   + DC L    H    +         WH   N +       
Sbjct: 405 SGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVW------SCTWHSCGNFVASSSLD- 457

Query: 359 PNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDT-LASAMGYHILI 417
                      +T  ++D NS +  C LY   +  ++S+ EF P  +T L S+    + I
Sbjct: 458 -----------KTSKIWDVNSERCRCTLYG-HTDSVNSI-EFFPFSNTLLTSSADKTLSI 504

Query: 418 WSQEEART 425
           W   +ART
Sbjct: 505 W---DART 509



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 44/176 (25%), Positives = 73/176 (41%), Gaps = 9/176 (5%)

Query: 134 GDIMLWN-FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNIL 191
           G+  LW   G+      + G G    ++   F+P + ++   SS + T +L D  KG+ +
Sbjct: 371 GEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHP-SGDKLATSSGDTTVKLWDLCKGDCI 429

Query: 192 RVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALN 251
             F       +W C+     +     + D    +  +N +      L  H   V  +   
Sbjct: 430 LTFEGHSRA-VWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRC-TLYGHTDSVNSIEFF 487

Query: 252 PCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307
           P  +  L T+S D+T+ IWD R    + S LY   H H +N A F P G  + + D
Sbjct: 488 PFSNTLL-TSSADKTLSIWDARTGICEQS-LYG--HMHSINDAIFDPRGHMIASCD 539


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 16/129 (12%)

Query: 202 IWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM---HKKKVTHVALNPCCDWFL 258
           +W   LD+S  S    +G +     L + D    + LR+   H   V  V  +P  + +L
Sbjct: 387 VW--DLDISPYSLYFASGSHDRTARLWSFD--RTYPLRIYAGHLADVDCVKFHPNSN-YL 441

Query: 259 ATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 318
           AT S D+TV++W  +Q  G +  L++  HR PV +  FSP+G  L +  +   +++    
Sbjct: 442 ATGSTDKTVRLWSAQQ--GNSVRLFT-GHRGPVLSLAFSPNGKYLASAGEDQRLKL---- 494

Query: 319 QWDCPLGLI 327
            WD   G +
Sbjct: 495 -WDLASGTL 502



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 41/150 (27%), Positives = 70/150 (46%), Gaps = 13/150 (8%)

Query: 128 AVGSKGGDIMLWNFGIKDKPTFIKGIGAG--GSITGLKFNPLNTNQFYASSMEGTTRLQD 185
           A GS      LW+F      T+   I AG    +  +KF+P N+N     S + T RL  
Sbjct: 400 ASGSHDRTARLWSFD----RTYPLRIYAGHLADVDCVKFHP-NSNYLATGSTDKTVRLWS 454

Query: 186 FK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWN-LRMHKK 243
            + GN +R+F       +   SL  S + + + +      + L ++    L+  LR H  
Sbjct: 455 AQQGNSVRLFTGHRGPVL---SLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD 511

Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDLR 273
            +T +  +P     +A+AS+D +V++WD+R
Sbjct: 512 NITSLTFSPDSG-LIASASMDNSVRVWDIR 540



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 25/161 (15%)

Query: 172 FYASSMEGTTRLQDFKGNI-LRVFAS--SDTINIWFCSLDVSASSRMVVTGDNVGNVILL 228
           F + S + T RL  F     LR++A   +D   + F       +S  + TG     V L 
Sbjct: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKF-----HPNSNYLATGSTDKTVRLW 453

Query: 229 N-MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL------RQVRGKASF 281
           +   G  +     H+  V  +A +P    +LA+A  DQ +K+WDL      +++RG    
Sbjct: 454 SAQQGNSVRLFTGHRGPVLSLAFSPNGK-YLASAGEDQRLKLWDLASGTLYKELRG---- 508

Query: 282 LYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322
                H   + +  FSPD   + +    + +RV+      C
Sbjct: 509 -----HTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544


>gi|55741849 WD repeat domain 22 [Homo sapiens]
          Length = 942

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 4/109 (3%)

Query: 204 FCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASV 263
           FC L  ++ +  V +G N   VIL +++  E  ++  H+  V  ++++P  D   A++S 
Sbjct: 105 FC-LAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSD 163

Query: 264 DQTVKIWDLRQ-VRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSE 311
           D  V IWD+R+   G+   L + P     ++  F+P   RLL T    E
Sbjct: 164 DGRVLIWDIRESPHGEPFCLANYP--SAFHSVMFNPVEPRLLATANSKE 210



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 40/153 (26%), Positives = 63/153 (41%), Gaps = 16/153 (10%)

Query: 133 GGD---IMLWNFG----IKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 185
           GGD   ++LW+       + KP  +KG     +I  L FN  NT  F   + E       
Sbjct: 72  GGDDRRVLLWHMEQAIHSRVKPIQLKG-EHHSNIFCLAFNSGNTKVFSGGNDEQVILHDV 130

Query: 186 FKGNILRVFASSDTINIWFCSLDVS-ASSRMVVTGDNVGNVILLNMDGK---ELWNLRMH 241
                L VFA  D +      L VS  +  +  +  + G V++ ++      E + L  +
Sbjct: 131 ESSETLDVFAHEDAVY----GLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANY 186

Query: 242 KKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ 274
                 V  NP     LATA+  + V +WD+R+
Sbjct: 187 PSAFHSVMFNPVEPRLLATANSKEGVGLWDIRK 219


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 13/175 (7%)

Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213
           G  G + G  F+P + N   +SS +GT RL   +     V        +W      S   
Sbjct: 541 GHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPYG 597

Query: 214 RMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272
              V+G +     L   D  + L     H   V     +P  + ++AT S D+TV++WD+
Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN-YVATGSADRTVRLWDV 656

Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327
             + G    +++  H+ P+++  FSP+G  L T      + +     WD   GL+
Sbjct: 657 --LNGNCVRIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLL-----WDIGHGLM 703



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 7/111 (6%)

Query: 163 KFNPLNTNQFYASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDN 221
           +F+P N+N     S + T RL D   GN +R+F           SL  S + R + TG  
Sbjct: 634 RFHP-NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP---IHSLTFSPNGRFLATGAT 689

Query: 222 VGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271
            G V+L ++  G  +  L+ H   V  +  +   +  LA+ S+D TV++WD
Sbjct: 690 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 739


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 10/83 (12%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNAACFSPDGARLLTTDQK 309
           NP  +  LA+AS D TV++WD+     +   +++L  H+ PV +  FSPDG  L +    
Sbjct: 408 NPNANLMLASASFDSTVRLWDV----DRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFD 463

Query: 310 SEIRVYSASQWDCPLGLIPHPHR 332
             + +     W+   G + H +R
Sbjct: 464 KCVHI-----WNTQTGALVHSYR 481



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 36/162 (22%), Positives = 56/162 (34%), Gaps = 39/162 (24%)

Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQ 265
           SLD ++   ++ TG   G   +   DG     L  HK  +  +  N   + F+ +A VD+
Sbjct: 230 SLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGN-FILSAGVDK 288

Query: 266 TVKIWDLRQVRGKASF-LYSLP-------------------------------------H 287
           T  IWD      K  F  +S P                                     H
Sbjct: 289 TTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGH 348

Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329
            + VNA  + P G  L +      ++++S  Q +C   L  H
Sbjct: 349 TNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAH 390



 Score = 32.3 bits (72), Expect = 0.84
 Identities = 55/231 (23%), Positives = 98/231 (42%), Gaps = 27/231 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLN 168
           P ++  TSL W+ +  + +A GS  G   +W    KD           G I  LK+N   
Sbjct: 223 PSNKDVTSLDWN-SEGTLLATGSYDGFARIWT---KDGNLASTLGQHKGPIFALKWNKKG 278

Query: 169 TNQFYASSMEGTTRLQDFKGNILRV---FASSDTINIWFCSLDVSASSRMVVTGDNVGNV 225
            N   ++ ++ TT + D      +    F S+  +++ + S +  AS     + D   +V
Sbjct: 279 -NFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASC----STDMCIHV 333

Query: 226 ILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285
             L  D + +   + H  +V  +  +P  +  LA+ S D T+KIW ++Q     + ++ L
Sbjct: 334 CKLGQD-RPIKTFQGHTNEVNAIKWDPTGN-LLASCSDDMTLKIWSMKQ----DNCVHDL 387

Query: 286 -PHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS------QWDCPLGLIPH 329
             H   +    +SP G    T +  + + + SAS       WD   G+  H
Sbjct: 388 QAHNKEIYTIKWSPTGPG--TNNPNANLMLASASFDSTVRLWDVDRGICIH 436



 Score = 30.0 bits (66), Expect = 4.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 165 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLSENSTSGSTQLVLRH 213


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 8/82 (9%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
           NP  +  LA+AS D TV++WD+   RG  +   +  H+ PV +  FSPDG  L +     
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIE--RGVCTHTLT-KHQEPVYSVAFSPDGKYLASGSFDK 476

Query: 311 EIRVYSASQWDCPLGLIPHPHR 332
            + +     W+   G + H +R
Sbjct: 477 CVHI-----WNTQSGNLVHSYR 493



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 55/231 (23%), Positives = 96/231 (41%), Gaps = 27/231 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-GSITGLKFNPL 167
           P ++  TSL W+ T+ + +A GS  G   +W     +       +G   G I  LK+N  
Sbjct: 235 PSNKDVTSLDWN-TNGTLLATGSYDGFARIWT----EDGNLASTLGQHKGPIFALKWNRK 289

Query: 168 NTNQFYASSMEGTTRLQDFKGNILRV---FASSDTINIWFCSLDVSASSRMVVTGDNVGN 224
             N   ++ ++ TT + D      +    F S+  +++ + +    AS     + D   +
Sbjct: 290 G-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASC----STDMCIH 344

Query: 225 VILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284
           V  L  D + +   + H  +V  +  +P     LA+ S D T+KIW ++Q   +      
Sbjct: 345 VCRLGCD-RPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ---EVCIHDL 399

Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS------QWDCPLGLIPH 329
             H   +    +SP G    T++  S I + SAS       WD   G+  H
Sbjct: 400 QAHNKEIYTIKWSPTGP--ATSNPNSNIMLASASFDSTVRLWDIERGVCTH 448



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 177 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRH 225


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 8/82 (9%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
           NP  +  LA+AS D TV++WD+   RG  +   +  H+ PV +  FSPDG  L +     
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIE--RGVCTHTLT-KHQEPVYSVAFSPDGKYLASGSFDK 476

Query: 311 EIRVYSASQWDCPLGLIPHPHR 332
            + +     W+   G + H +R
Sbjct: 477 CVHI-----WNTQSGNLVHSYR 493



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 55/231 (23%), Positives = 96/231 (41%), Gaps = 27/231 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-GSITGLKFNPL 167
           P ++  TSL W+ T+ + +A GS  G   +W     +       +G   G I  LK+N  
Sbjct: 235 PSNKDVTSLDWN-TNGTLLATGSYDGFARIWT----EDGNLASTLGQHKGPIFALKWNRK 289

Query: 168 NTNQFYASSMEGTTRLQDFKGNILRV---FASSDTINIWFCSLDVSASSRMVVTGDNVGN 224
             N   ++ ++ TT + D      +    F S+  +++ + +    AS     + D   +
Sbjct: 290 G-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASC----STDMCIH 344

Query: 225 VILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284
           V  L  D + +   + H  +V  +  +P     LA+ S D T+KIW ++Q   +      
Sbjct: 345 VCRLGCD-RPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ---EVCIHDL 399

Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS------QWDCPLGLIPH 329
             H   +    +SP G    T++  S I + SAS       WD   G+  H
Sbjct: 400 QAHNKEIYTIKWSPTGP--ATSNPNSNIMLASASFDSTVRLWDIERGVCTH 448



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 177 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRH 225


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 8/82 (9%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
           NP  +  LA+AS D TV++WD+   RG  +   +  H+ PV +  FSPDG  L +     
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIE--RGVCTHTLT-KHQEPVYSVAFSPDGKYLASGSFDK 527

Query: 311 EIRVYSASQWDCPLGLIPHPHR 332
            + +     W+   G + H +R
Sbjct: 528 CVHI-----WNTQSGNLVHSYR 544



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 55/231 (23%), Positives = 96/231 (41%), Gaps = 27/231 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-GSITGLKFNPL 167
           P ++  TSL W+ T+ + +A GS  G   +W     +       +G   G I  LK+N  
Sbjct: 286 PSNKDVTSLDWN-TNGTLLATGSYDGFARIWT----EDGNLASTLGQHKGPIFALKWNRK 340

Query: 168 NTNQFYASSMEGTTRLQDFKGNILRV---FASSDTINIWFCSLDVSASSRMVVTGDNVGN 224
             N   ++ ++ TT + D      +    F S+  +++ + +    AS     + D   +
Sbjct: 341 G-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASC----STDMCIH 395

Query: 225 VILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284
           V  L  D + +   + H  +V  +  +P     LA+ S D T+KIW ++Q   +      
Sbjct: 396 VCRLGCD-RPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ---EVCIHDL 450

Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS------QWDCPLGLIPH 329
             H   +    +SP G    T++  S I + SAS       WD   G+  H
Sbjct: 451 QAHNKEIYTIKWSPTGP--ATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 228 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRH 276


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 8/82 (9%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
           NP  +  LA+AS D TV++WD+   RG  +   +  H+ PV +  FSPDG  L +     
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIE--RGVCTHTLT-KHQEPVYSVAFSPDGKYLASGSFDK 527

Query: 311 EIRVYSASQWDCPLGLIPHPHR 332
            + +     W+   G + H +R
Sbjct: 528 CVHI-----WNTQSGNLVHSYR 544



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 55/231 (23%), Positives = 96/231 (41%), Gaps = 27/231 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-GSITGLKFNPL 167
           P ++  TSL W+ T+ + +A GS  G   +W     +       +G   G I  LK+N  
Sbjct: 286 PSNKDVTSLDWN-TNGTLLATGSYDGFARIWT----EDGNLASTLGQHKGPIFALKWNRK 340

Query: 168 NTNQFYASSMEGTTRLQDFKGNILRV---FASSDTINIWFCSLDVSASSRMVVTGDNVGN 224
             N   ++ ++ TT + D      +    F S+  +++ + +    AS     + D   +
Sbjct: 341 G-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASC----STDMCIH 395

Query: 225 VILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284
           V  L  D + +   + H  +V  +  +P     LA+ S D T+KIW ++Q   +      
Sbjct: 396 VCRLGCD-RPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ---EVCIHDL 450

Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS------QWDCPLGLIPH 329
             H   +    +SP G    T++  S I + SAS       WD   G+  H
Sbjct: 451 QAHNKEIYTIKWSPTGP--ATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 228 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRH 276


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 6/119 (5%)

Query: 210 SASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269
           S S+ +V   D+    I     GK L  L+ H   V     NP  +  + + S D++V+I
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRI 155

Query: 270 WDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327
           WD++   GK   L +LP H  PV+A  F+ DG+ ++++      R++  +   C   LI
Sbjct: 156 WDVKT--GKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 36/157 (22%), Positives = 68/157 (43%), Gaps = 8/157 (5%)

Query: 168 NTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226
           ++N   ++S + T ++ D   G  L+        N  FC  + +  S ++V+G    +V 
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS--NYVFCC-NFNPQSNLIVSGSFDESVR 154

Query: 227 LLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285
           + ++  GK L  L  H   V+ V  N      + ++S D   +IWD     G+       
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWDTAS--GQCLKTLID 211

Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322
               PV+   FSP+G  +L     + ++++  S+  C
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 6/119 (5%)

Query: 210 SASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269
           S S+ +V   D+    I     GK L  L+ H   V     NP  +  + + S D++V+I
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRI 155

Query: 270 WDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327
           WD++   GK   L +LP H  PV+A  F+ DG+ ++++      R++  +   C   LI
Sbjct: 156 WDVKT--GKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 36/157 (22%), Positives = 68/157 (43%), Gaps = 8/157 (5%)

Query: 168 NTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226
           ++N   ++S + T ++ D   G  L+        N  FC  + +  S ++V+G    +V 
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS--NYVFCC-NFNPQSNLIVSGSFDESVR 154

Query: 227 LLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285
           + ++  GK L  L  H   V+ V  N      + ++S D   +IWD     G+       
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWDTAS--GQCLKTLID 211

Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322
               PV+   FSP+G  +L     + ++++  S+  C
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248


>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
           sapiens]
          Length = 275

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/100 (27%), Positives = 46/100 (46%), Gaps = 2/100 (2%)

Query: 232 GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPV 291
           GK L NL  H + V  +   P     L +AS D+T+++WDL+        L    H++ V
Sbjct: 14  GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG--HQNWV 71

Query: 292 NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 331
            +  FSPD + L +      + +++  ++     L  H H
Sbjct: 72  YSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHH 111


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 8/82 (9%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
           NP     LA+AS D TV++WD+ Q  G  +    + H+ PV +  FSPDG  L +     
Sbjct: 418 NPNSSIMLASASFDSTVRLWDVEQ--GVCTHTL-MKHQEPVYSVAFSPDGKYLASGSFDK 474

Query: 311 EIRVYSASQWDCPLGLIPHPHR 332
            + +     W+   G + H ++
Sbjct: 475 YVHI-----WNTQSGSLVHSYQ 491



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 53/233 (22%), Positives = 97/233 (41%), Gaps = 26/233 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-GSITGLKFNPL 167
           P ++  TSL W+ +  + +A+GS  G   +W     +       +G   G I  LK+N  
Sbjct: 233 PSNKDVTSLDWN-SDGTLLAMGSYDGFARIWT----ENGNLASTLGQHKGPIFALKWNKK 287

Query: 168 NTNQFYASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSASSRMVVTG---DNVG 223
             N   ++ ++ TT + D   G   + F           +LDV   + M       D   
Sbjct: 288 G-NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAP-----ALDVDWQNNMTFASCSTDMCI 341

Query: 224 NVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ------VRG 277
           +V  L  D   +   + H  +V  +  +P     LA+ S D T+KIW ++Q      ++ 
Sbjct: 342 HVCRLGCD-HPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDACVHDLQA 399

Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQ-KSEIRVYSASQWDCPLGLIPH 329
            +  +Y++    P   A  +P+ + +L +    S +R++   Q  C   L+ H
Sbjct: 400 HSKEIYTIKW-SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKH 451



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 175 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRH 223


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 8/82 (9%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
           NP     LA+AS D TV++WD+ Q  G  +    + H+ PV +  FSPDG  L +     
Sbjct: 418 NPNSSIMLASASFDSTVRLWDVEQ--GVCTHTL-MKHQEPVYSVAFSPDGKYLASGSFDK 474

Query: 311 EIRVYSASQWDCPLGLIPHPHR 332
            + +     W+   G + H ++
Sbjct: 475 YVHI-----WNTQSGSLVHSYQ 491



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 53/233 (22%), Positives = 97/233 (41%), Gaps = 26/233 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-GSITGLKFNPL 167
           P ++  TSL W+ +  + +A+GS  G   +W     +       +G   G I  LK+N  
Sbjct: 233 PSNKDVTSLDWN-SDGTLLAMGSYDGFARIWT----ENGNLASTLGQHKGPIFALKWNKK 287

Query: 168 NTNQFYASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSASSRMVVTG---DNVG 223
             N   ++ ++ TT + D   G   + F           +LDV   + M       D   
Sbjct: 288 G-NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAP-----ALDVDWQNNMTFASCSTDMCI 341

Query: 224 NVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ------VRG 277
           +V  L  D   +   + H  +V  +  +P     LA+ S D T+KIW ++Q      ++ 
Sbjct: 342 HVCRLGCD-HPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDACVHDLQA 399

Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQ-KSEIRVYSASQWDCPLGLIPH 329
            +  +Y++    P   A  +P+ + +L +    S +R++   Q  C   L+ H
Sbjct: 400 HSKEIYTIKW-SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKH 451



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 175 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRH 223


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 8/82 (9%)

Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310
           NP     LA+AS D TV++WD+ Q  G  +    + H+ PV +  FSPDG  L +     
Sbjct: 418 NPNSSIMLASASFDSTVRLWDVEQ--GVCTHTL-MKHQEPVYSVAFSPDGKYLASGSFDK 474

Query: 311 EIRVYSASQWDCPLGLIPHPHR 332
            + +     W+   G + H ++
Sbjct: 475 YVHI-----WNTQSGSLVHSYQ 491



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 53/233 (22%), Positives = 97/233 (41%), Gaps = 26/233 (11%)

Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-GSITGLKFNPL 167
           P ++  TSL W+ +  + +A+GS  G   +W     +       +G   G I  LK+N  
Sbjct: 233 PSNKDVTSLDWN-SDGTLLAMGSYDGFARIWT----ENGNLASTLGQHKGPIFALKWNKK 287

Query: 168 NTNQFYASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSASSRMVVTG---DNVG 223
             N   ++ ++ TT + D   G   + F           +LDV   + M       D   
Sbjct: 288 G-NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAP-----ALDVDWQNNMTFASCSTDMCI 341

Query: 224 NVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ------VRG 277
           +V  L  D   +   + H  +V  +  +P     LA+ S D T+KIW ++Q      ++ 
Sbjct: 342 HVCRLGCD-HPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDACVHDLQA 399

Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQ-KSEIRVYSASQWDCPLGLIPH 329
            +  +Y++    P   A  +P+ + +L +    S +R++   Q  C   L+ H
Sbjct: 400 HSKEIYTIKW-SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKH 451



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 1/50 (2%)

Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287
           LR H+ +V   A NP  D  LA+ S D T +IW+L +     S    L H
Sbjct: 175 LRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRH 223


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,823,121
Number of Sequences: 37866
Number of extensions: 828921
Number of successful extensions: 2581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 2075
Number of HSP's gapped (non-prelim): 531
length of query: 427
length of database: 18,247,518
effective HSP length: 105
effective length of query: 322
effective length of database: 14,271,588
effective search space: 4595451336
effective search space used: 4595451336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.