Guide to the Human Genome
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Search of human proteins with 45446752

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45446752 aquaporin 8 [Homo sapiens]
         (261 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45446752 aquaporin 8 [Homo sapiens]                                526   e-150
gi|4502183 aquaporin 5 [Homo sapiens]                                 129   2e-30
gi|4502179 aquaporin 2 [Homo sapiens]                                 119   2e-27
gi|4755125 aquaporin 4 isoform b [Homo sapiens]                       117   8e-27
gi|4502181 aquaporin 4 isoform a [Homo sapiens]                       117   8e-27
gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]       112   2e-25
gi|86792455 aquaporin 6 [Homo sapiens]                                108   6e-24
gi|37694062 aquaporin 1 [Homo sapiens]                                 99   4e-21
gi|157266307 aquaporin 9 [Homo sapiens]                                81   8e-16
gi|4826645 aquaporin 3 [Homo sapiens]                                  77   2e-14
gi|4502187 aquaporin 7 [Homo sapiens]                                  58   7e-09
gi|22538420 aquaporin 10 [Homo sapiens]                                53   2e-07
gi|156447037 aquaporin 12B [Homo sapiens]                              38   0.010
gi|40538880 aquaporin 12A [Homo sapiens]                               37   0.023
gi|27370565 aquaporin 11 [Homo sapiens]                                36   0.030
gi|6912666 sialin [Homo sapiens]                                       34   0.15 
gi|83921614 cytochrome b5 outer mitochondrial membrane precursor...    30   2.8  
gi|197100650 NTPase, KAP family P-loop domain containing 1 isofo...    29   3.6  
gi|115647960 NTPase, KAP family P-loop domain containing 1 isofo...    29   3.6  
gi|115511028 transmembrane 4 L six family member 19 [Homo sapiens]     29   3.6  
gi|117968621 MACRO domain containing 2 isoform 1 [Homo sapiens]        29   4.7  
gi|4505697 pendrin [Homo sapiens]                                      28   6.2  
gi|110431350 endo-beta-N-acetylglucosaminidase [Homo sapiens]          28   6.2  
gi|73611906 phosphorylase kinase, beta isoform b [Homo sapiens]        28   8.1  
gi|4505783 phosphorylase kinase, beta isoform a [Homo sapiens]         28   8.1  

>gi|45446752 aquaporin 8 [Homo sapiens]
          Length = 261

 Score =  526 bits (1356), Expect = e-150
 Identities = 261/261 (100%), Positives = 261/261 (100%)

Query: 1   MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENG 60
           MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENG
Sbjct: 1   MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENG 60

Query: 61  TDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLG 120
           TDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLG
Sbjct: 61  TDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLG 120

Query: 121 GMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEK 180
           GMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEK
Sbjct: 121 GMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEK 180

Query: 181 TKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLL 240
           TKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLL
Sbjct: 181 TKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLL 240

Query: 241 VGLLIRCFIGDGKTRLILKAR 261
           VGLLIRCFIGDGKTRLILKAR
Sbjct: 241 VGLLIRCFIGDGKTRLILKAR 261


>gi|4502183 aquaporin 5 [Homo sapiens]
          Length = 265

 Score =  129 bits (325), Expect = 2e-30
 Identities = 80/215 (37%), Positives = 124/215 (57%), Gaps = 8/215 (3%)

Query: 34  FVQPCLVELLGSALFIFIGCLSVIE--NGTDTGLLQPALAHGLALGLVIATLGNISGGHF 91
           F++    E L + +F+F G  S ++  +   T +LQ ALA GLA+G +   LG +SGGH 
Sbjct: 10  FLKAVFAEFLATLIFVFFGLGSALKWPSALPT-ILQIALAFGLAIGTLAQALGPVSGGHI 68

Query: 92  NPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQ 151
           NPA++LA ++   ++L+    Y  +QL+G + GA +   V+P     N +  A      Q
Sbjct: 69  NPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQ 128

Query: 152 GQVAGALVAEIILTTLLALAVCMGAINEKTKGPLAP-FSIGFAVTVDILAGGPVSGGCMN 210
           GQ   A+V E+ILT  LAL +     + +T    +P  SIG +VT+  L G   +G  MN
Sbjct: 129 GQ---AMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMN 185

Query: 211 PARAFGPAVVANHWN-FHWIYWLGPLLAGLLVGLL 244
           PAR+FGPAVV N ++  HW++W+GP++  +L  +L
Sbjct: 186 PARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAIL 220


>gi|4502179 aquaporin 2 [Homo sapiens]
          Length = 271

 Score =  119 bits (299), Expect = 2e-27
 Identities = 74/214 (34%), Positives = 113/214 (52%), Gaps = 7/214 (3%)

Query: 34  FVQPCLVELLGSALFIFIGCLSVIE-NGTDTGLLQPALAHGLALGLVIATLGNISGGHFN 92
           F +    E L + LF+F G  S +        +LQ A+A GL +G ++  LG+ISG H N
Sbjct: 9   FSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHIN 68

Query: 93  PAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQG 152
           PAV++A ++   ++++    Y  +QLLG + GAAL   ++P +      G   V      
Sbjct: 69  PAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPAD----IRGDLAVNALSNS 124

Query: 153 QVAG-ALVAEIILTTLLALAVCMGAINEKTKGPLAP-FSIGFAVTVDILAGGPVSGGCMN 210
             AG A+  E+ LT  L L +       + + P  P  SIGF+V +  L G   +G  MN
Sbjct: 125 TTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMN 184

Query: 211 PARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLL 244
           PAR+  PAVV   ++ HW++W+GPL+  +L  LL
Sbjct: 185 PARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLL 218


>gi|4755125 aquaporin 4 isoform b [Homo sapiens]
          Length = 301

 Score =  117 bits (294), Expect = 8e-27
 Identities = 74/221 (33%), Positives = 116/221 (52%), Gaps = 13/221 (5%)

Query: 30  WYERFVQPCLVELLGSALFIFIGCLSVIE-NGTDTGLLQPALAHGLALGLVIATL----G 84
           W + F +    E L   +F+ +   S I   GT+  L    +   L  GL IAT+    G
Sbjct: 8   WTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFG 67

Query: 85  NISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAA 144
           +ISGGH NPAV++A +    +++   + Y  +Q LG ++GA +   V+P     +  G  
Sbjct: 68  HISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPP----SVVGGL 123

Query: 145 FVTVQEQGQVAG-ALVAEIILTTLLALAVCMGAINEKTK--GPLAPFSIGFAVTVDILAG 201
            VT+      AG  L+ E+I+T  L   +     +++T   G +A  +IGF+V +  L  
Sbjct: 124 GVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-LAIGFSVAIGHLFA 182

Query: 202 GPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVG 242
              +G  MNPAR+FGPAV+  +W  HWIYW+GP++  +L G
Sbjct: 183 INYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAG 223


>gi|4502181 aquaporin 4 isoform a [Homo sapiens]
          Length = 323

 Score =  117 bits (294), Expect = 8e-27
 Identities = 74/221 (33%), Positives = 116/221 (52%), Gaps = 13/221 (5%)

Query: 30  WYERFVQPCLVELLGSALFIFIGCLSVIE-NGTDTGLLQPALAHGLALGLVIATL----G 84
           W + F +    E L   +F+ +   S I   GT+  L    +   L  GL IAT+    G
Sbjct: 30  WTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFG 89

Query: 85  NISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAA 144
           +ISGGH NPAV++A +    +++   + Y  +Q LG ++GA +   V+P     +  G  
Sbjct: 90  HISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPP----SVVGGL 145

Query: 145 FVTVQEQGQVAG-ALVAEIILTTLLALAVCMGAINEKTK--GPLAPFSIGFAVTVDILAG 201
            VT+      AG  L+ E+I+T  L   +     +++T   G +A  +IGF+V +  L  
Sbjct: 146 GVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-LAIGFSVAIGHLFA 204

Query: 202 GPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVG 242
              +G  MNPAR+FGPAV+  +W  HWIYW+GP++  +L G
Sbjct: 205 INYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAG 245


>gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]
          Length = 263

 Score =  112 bits (281), Expect = 2e-25
 Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 7/214 (3%)

Query: 34  FVQPCLVELLGSALFIFIGCLSVIENGTDT-GLLQPALAHGLALGLVIATLGNISGGHFN 92
           F +    E   +  ++F G  S +        +LQ A+A GLAL  ++ ++G+ISG H N
Sbjct: 9   FWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHISGAHVN 68

Query: 93  PAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQG 152
           PAV+ A ++   ++L+    Y  +QLLG + GAA+  +V+P     N    A  T+    
Sbjct: 69  PAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGN---LALNTLHPAV 125

Query: 153 QVAGALVAEIILTTLLALAVCMGAINEKTKGPL--APFSIGFAVTVDILAGGPVSGGCMN 210
            V  A   EI LT    L +     +E+  G L     ++GF++ +  L G   +G  MN
Sbjct: 126 SVGQATTVEIFLTLQFVLCI-FATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGMN 184

Query: 211 PARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLL 244
           PAR+F PA++  ++  HW+YW+GP++ G L  LL
Sbjct: 185 PARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLL 218


>gi|86792455 aquaporin 6 [Homo sapiens]
          Length = 282

 Score =  108 bits (269), Expect = 6e-24
 Identities = 67/205 (32%), Positives = 103/205 (50%), Gaps = 5/205 (2%)

Query: 41  ELLGSALFIFIGCLSVIENGTDT-GLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAA 99
           E L + L++F G  SV+   T    +LQ A+   L   + +      SG H NPAV+LA 
Sbjct: 30  EFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAF 89

Query: 100 MLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALV 159
           ++   ++L   + Y  +QL+G  +GAAL   V P +            V+       A+ 
Sbjct: 90  LVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDI---RETLGINVVRNSVSTGQAVA 146

Query: 160 AEIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAV 219
            E++LT  L L V     + +T G  A   IG +V +  L G   +G  MNPAR+FGPA+
Sbjct: 147 VELLLTLQLVLCVFASTDSRQTSGSPATM-IGISVALGHLIGIHFTGCSMNPARSFGPAI 205

Query: 220 VANHWNFHWIYWLGPLLAGLLVGLL 244
           +   +  HW++W+GPL+  LL  L+
Sbjct: 206 IIGKFTVHWVFWVGPLMGALLASLI 230


>gi|37694062 aquaporin 1 [Homo sapiens]
          Length = 269

 Score = 99.0 bits (245), Expect = 4e-21
 Identities = 70/222 (31%), Positives = 113/222 (50%), Gaps = 16/222 (7%)

Query: 34  FVQPCLVELLGSALFIFIGCLSVI----ENGTDTGLLQPALAHGLALGLVIATL----GN 85
           F +  + E L + LF+FI   S +      G +   +Q  +   LA GL IATL    G+
Sbjct: 10  FWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGH 69

Query: 86  ISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAF 145
           ISG H NPAV+L  +L   +++   L Y ++Q +G ++  A+   ++      +      
Sbjct: 70  ISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDL 129

Query: 146 VTVQEQGQVAGALVAEIILTTLLALAVCMGAINEKTK---GPLAPFSIGFAVTVDILAGG 202
                 GQ  G    EII T  L L +C+ A  ++ +   G  AP +IG +V +  L   
Sbjct: 130 ADGVNSGQGLGI---EIIGT--LQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAI 184

Query: 203 PVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLL 244
             +G  +NPAR+FG AV+ ++++ HWI+W+GP + G L  L+
Sbjct: 185 DYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLI 226


>gi|157266307 aquaporin 9 [Homo sapiens]
          Length = 295

 Score = 81.3 bits (199), Expect = 8e-16
 Identities = 65/235 (27%), Positives = 101/235 (42%), Gaps = 29/235 (12%)

Query: 39  LVELLGSALFIFIGC----LSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPA 94
           L E LG+ + I +GC     +++  G   G++   +   +A+ + I   G +SGGH NPA
Sbjct: 27  LSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPA 86

Query: 95  VSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERF-----------WNASGA 143
           VSLA  L G +    L  Y  +Q LG  +GAA    +  +               NA+  
Sbjct: 87  VSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAH 146

Query: 144 AFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEKTKGP---LAPFSIGFAVTVDILA 200
            F T            A+ ++ T++ L +     + +  G    L P +IG  + V   +
Sbjct: 147 IFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASS 206

Query: 201 GGPVSGGCMNPARAFGPAV--VANHW---------NFHWIYWLGPLLAGLLVGLL 244
            G  SG  MNPAR   P +      W         NF WI  +GPL+  ++ GL+
Sbjct: 207 LGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLI 261


>gi|4826645 aquaporin 3 [Homo sapiens]
          Length = 292

 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 75/253 (29%), Positives = 108/253 (42%), Gaps = 39/253 (15%)

Query: 33  RFVQPCLVELLGSALFIFIGCLSV----IENGTDTGLLQPALAHGLALGLVIATLGNISG 88
           R ++  L E LG+ + +  GC SV    +  GT  G L   LA G A+ L I   G +SG
Sbjct: 20  RLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSG 79

Query: 89  GHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFW---------- 138
            H NPAV+ A   +     + L  Y ++Q LG  LGA +   +   +  W          
Sbjct: 80  AHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLY-YDAIWHFADNQLFVS 138

Query: 139 --NASGAAFVTVQE-QGQVAGALVAEIILTTLLALAVCMGAINEKTKGP----LAPFSIG 191
             N +   F T       +      + I T   +L VC+ AI +    P    L  F++G
Sbjct: 139 GPNGTAGIFATYPSGHLDMINGFFDQFIGTA--SLIVCVLAIVDPYNNPVPRGLEAFTVG 196

Query: 192 FAVTVDILAGGPVSGGCMNPARAFGP-----------AVVANHWNFHWIYWLGPLL---A 237
             V V   + G  SG  +NPAR FGP           AV     ++ W+  + PLL   A
Sbjct: 197 LVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIA 256

Query: 238 GLLV-GLLIRCFI 249
           G+ V  L+I C +
Sbjct: 257 GVFVYQLMIGCHL 269


>gi|4502187 aquaporin 7 [Homo sapiens]
          Length = 342

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 68/261 (26%), Positives = 103/261 (39%), Gaps = 40/261 (15%)

Query: 33  RFVQPCLVELLGSALFIFIGCLSV---IENGTDTGLLQPALAHGLALGLVIATLGNISGG 89
           + V+  L E + + + +  G  SV   + N      L   L  G  + + +   G ISG 
Sbjct: 32  KMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGA 91

Query: 90  HFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQ 149
           H N AV+ A   +G +       Y + Q LG  L AA   ++        + G   VT  
Sbjct: 92  HMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVT-- 149

Query: 150 EQGQVAGA----------------LVAEIILTTLLALAVCMGAINEKTKGPLAP----FS 189
             G VA A                 + E  LT +L L  C+ AI ++   P  P      
Sbjct: 150 --GPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQL--CLFAITDQENNPALPGTEALV 205

Query: 190 IGFAVTVDILAGGPVSGGCMNPAR-----------AFGPAVVANHWNFHWIYWLGPLLAG 238
           IG  V +  ++ G  +G  +NP+R            +G  V +N  N+ W+  + PLL  
Sbjct: 206 IGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGA 265

Query: 239 LLVGLLIRCFIGDGKTRLILK 259
            L G++   FIG    R  LK
Sbjct: 266 YLGGIIYLVFIGSTIPREPLK 286


>gi|22538420 aquaporin 10 [Homo sapiens]
          Length = 301

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 55/200 (27%), Positives = 82/200 (41%), Gaps = 22/200 (11%)

Query: 38  CLVELLGSALFIFIG----CLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNP 93
           CL E LG  + + +       +V    T        LA  LA+ + I   GN+SG H NP
Sbjct: 24  CLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLNP 83

Query: 94  AVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQ 153
           A SLA  ++G L  V L  Y + QLL     A+ A  V   +   N +G   +TV    +
Sbjct: 84  AFSLAMCIVGRLPWVKLPIYILVQLLSAFC-ASGATYVLYHDALQNYTGGN-LTVTGPKE 141

Query: 154 VAGALVA-------------EIILTTLLALAVCMGAINEKTKG---PLAPFSIGFAVTVD 197
            A                  + +L T + +   +  ++ + KG    L P  +G  +   
Sbjct: 142 TASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILAL 201

Query: 198 ILAGGPVSGGCMNPARAFGP 217
            L+ G   G  +NPAR  GP
Sbjct: 202 GLSMGANCGIPLNPARDLGP 221



 Score = 31.6 bits (70), Expect = 0.73
 Identities = 27/88 (30%), Positives = 37/88 (42%), Gaps = 3/88 (3%)

Query: 153 QVAGALVAEIILTTLLALAVCMGAINEKTKGPLAPFSIG--FAVTVDILAGGPVSGGCMN 210
           Q     +   +L  L   AV     + +TKG      +    AVT+ I  GG VSG  +N
Sbjct: 23  QCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLN 82

Query: 211 PARAFGPAVVAN-HWNFHWIYWLGPLLA 237
           PA +    +V    W    IY L  LL+
Sbjct: 83  PAFSLAMCIVGRLPWVKLPIYILVQLLS 110


>gi|156447037 aquaporin 12B [Homo sapiens]
          Length = 307

 Score = 37.7 bits (86), Expect = 0.010
 Identities = 52/207 (25%), Positives = 74/207 (35%), Gaps = 20/207 (9%)

Query: 50  FIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVM 109
           F+   +++E G   G   P L   L   L +A    + G   NP VSL   L+   +L  
Sbjct: 51  FLEMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPG 110

Query: 110 LLPYWVSQLLGGMLGAALAKAVSP---------EERFWNASGAAFVTVQEQGQVAGALVA 160
            L    +Q LG      L +             +     +  +A  T    G +  A  A
Sbjct: 111 TLLKLAAQGLGMQAACTLTRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACA 170

Query: 161 EIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVV 220
                TLL L     A +    GP    ++   VTV     GP +    NPA A      
Sbjct: 171 FCFHLTLLHLRHSPPAYS----GP----AVALLVTVTAYTAGPFTSAFFNPALAASVTFA 222

Query: 221 ANH---WNFHWIYWLGPLLAGLLVGLL 244
            +      +  +YWLGPL   +L  LL
Sbjct: 223 CSGHTLLEYVQVYWLGPLTGMVLAVLL 249


>gi|40538880 aquaporin 12A [Homo sapiens]
          Length = 295

 Score = 36.6 bits (83), Expect = 0.023
 Identities = 51/202 (25%), Positives = 72/202 (35%), Gaps = 20/202 (9%)

Query: 55  SVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYW 114
           +++E G   G   P L   L   L +A    + G   NP VSL   L+   +L   L   
Sbjct: 44  TLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKL 103

Query: 115 VSQLLGGMLGAALAKAVSP---------EERFWNASGAAFVTVQEQGQVAGALVAEIILT 165
            +Q LG      L +             +     +  +A  T    G +  A  A     
Sbjct: 104 AAQGLGMQAACTLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHL 163

Query: 166 TLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANH-- 223
           TLL L     A +    GP    ++   VTV     GP +    NPA A       +   
Sbjct: 164 TLLHLRHSPPAYS----GP----AVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHT 215

Query: 224 -WNFHWIYWLGPLLAGLLVGLL 244
              +  +YWLGPL   +L  LL
Sbjct: 216 LLEYVQVYWLGPLTGMVLAVLL 237


>gi|27370565 aquaporin 11 [Homo sapiens]
          Length = 271

 Score = 36.2 bits (82), Expect = 0.030
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 34/194 (17%)

Query: 69  ALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLN----LVMLLPYWVSQLLGGMLG 124
           +L HGL L           G   NP   +  M++GG++     V LL   VS L      
Sbjct: 86  SLVHGLTL----------VGTSSNPCGVMMQMMLGGMSPETGAVRLLAQLVSALCSRYCT 135

Query: 125 AALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAIN------ 178
           +AL          W+  G     V E+       +   +L  ++  AVC    +      
Sbjct: 136 SAL----------WSL-GLTQYHVSERSFACKNPIRVDLLKAVITEAVCSFLFHSALLHF 184

Query: 179 EKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHW---NFHWIYWLGPL 235
           ++ +  L    +   +T  + AGG ++G   NPA A     +        F  +YWL P 
Sbjct: 185 QEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFMCFDEAFPQFFIVYWLAPS 244

Query: 236 LAGLLVGLLIRCFI 249
           L  LL+ L+   F+
Sbjct: 245 LGILLMILMFSFFL 258


>gi|6912666 sialin [Homo sapiens]
          Length = 495

 Score = 33.9 bits (76), Expect = 0.15
 Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 34/132 (25%)

Query: 39  LVELLGSALFI----FIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPA 94
           L+ ++G A+F+    FIGC        D  L    L     LG   ++    S  H + A
Sbjct: 369 LIGMIGPAVFLVAAGFIGC--------DYSLAVAFLTISTTLGGFCSS--GFSINHLDIA 418

Query: 95  VSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERF--W----------NASG 142
            S A +L+G  N    +P        GM+G  +AK+++P+     W          N  G
Sbjct: 419 PSYAGILLGITNTFATIP--------GMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFG 470

Query: 143 AAFVTVQEQGQV 154
           A F T+  +G+V
Sbjct: 471 AIFFTLFAKGEV 482


>gi|83921614 cytochrome b5 outer mitochondrial membrane precursor
           [Homo sapiens]
          Length = 150

 Score = 29.6 bits (65), Expect = 2.8
 Identities = 9/27 (33%), Positives = 17/27 (62%)

Query: 228 WIYWLGPLLAGLLVGLLIRCFIGDGKT 254
           W YW+ P++  +L+G L R +  + K+
Sbjct: 123 WAYWILPIIGAVLLGFLYRYYTSESKS 149


>gi|197100650 NTPase, KAP family P-loop domain containing 1 isoform
           1 [Homo sapiens]
          Length = 619

 Score = 29.3 bits (64), Expect = 3.6
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 6/52 (11%)

Query: 64  GLLQPALAHGLALGLVIATLGNISGGHFNPAVSL------AAMLIGGLNLVM 109
           GLL    A GL +GL+  +LG  + GH +P+ SL      AA  + G  L+M
Sbjct: 130 GLLALLAALGLGVGLLYLSLGGHALGHGSPSGSLLKVFGGAATTLSGSGLLM 181


>gi|115647960 NTPase, KAP family P-loop domain containing 1 isoform
           2 [Homo sapiens]
          Length = 610

 Score = 29.3 bits (64), Expect = 3.6
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 6/52 (11%)

Query: 64  GLLQPALAHGLALGLVIATLGNISGGHFNPAVSL------AAMLIGGLNLVM 109
           GLL    A GL +GL+  +LG  + GH +P+ SL      AA  + G  L+M
Sbjct: 121 GLLALLAALGLGVGLLYLSLGGHALGHGSPSGSLLKVFGGAATTLSGSGLLM 172


>gi|115511028 transmembrane 4 L six family member 19 [Homo sapiens]
          Length = 209

 Score = 29.3 bits (64), Expect = 3.6
 Identities = 14/32 (43%), Positives = 21/32 (65%), Gaps = 1/32 (3%)

Query: 94  AVSLAAMLIGGLNLVMLLPYW-VSQLLGGMLG 124
           ++  AA+   G N+ +LLP W V+ LL G+LG
Sbjct: 21  SLGTAALFAAGANVALLLPNWDVTYLLRGLLG 52


>gi|117968621 MACRO domain containing 2 isoform 1 [Homo sapiens]
          Length = 425

 Score = 28.9 bits (63), Expect = 4.7
 Identities = 25/90 (27%), Positives = 37/90 (41%), Gaps = 12/90 (13%)

Query: 3   GEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENGTD 62
           G+I + E +   + A    +GG        R   PCL+            C ++  NG D
Sbjct: 77  GDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLA----------ECRNL--NGCD 124

Query: 63  TGLLQPALAHGLALGLVIATLGNISGGHFN 92
           TG  +    + L    VI T+G I+ GH N
Sbjct: 125 TGHAKITCGYDLPAKYVIHTVGPIARGHIN 154


>gi|4505697 pendrin [Homo sapiens]
          Length = 780

 Score = 28.5 bits (62), Expect = 6.2
 Identities = 28/116 (24%), Positives = 48/116 (41%), Gaps = 11/116 (9%)

Query: 95  VSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAA--------LAKAVSPEERFWNASGAAFV 146
           V +  ++ GGL +  ++ Y    L+GG   AA        L   ++   + +N   +   
Sbjct: 196 VGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIY 255

Query: 147 TVQEQGQVAGALVAEIILTTLLALAVCMGA--INEKTKGPLAPFSIGFAVTVDILA 200
           T+ E  Q  G          LL + VCM    +N++ +  + P  I   V V I+A
Sbjct: 256 TLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKI-PVPIPIEVIVTIIA 310


>gi|110431350 endo-beta-N-acetylglucosaminidase [Homo sapiens]
          Length = 743

 Score = 28.5 bits (62), Expect = 6.2
 Identities = 13/44 (29%), Positives = 23/44 (52%)

Query: 76  LGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLL 119
           +G+ +   GN+ GG F+   SL  +   G ++ +  P WV + L
Sbjct: 327 VGVDVFARGNVVGGRFDTDKSLELIRKHGFSVALFAPGWVYECL 370


>gi|73611906 phosphorylase kinase, beta isoform b [Homo sapiens]
          Length = 1086

 Score = 28.1 bits (61), Expect = 8.1
 Identities = 14/34 (41%), Positives = 18/34 (52%)

Query: 72  HGLALGLVIATLGNISGGHFNPAVSLAAMLIGGL 105
           HG  L LV+    NI G  FNP + + A L  G+
Sbjct: 605 HGRPLFLVLIREDNIRGSRFNPILDMLAALKKGI 638


>gi|4505783 phosphorylase kinase, beta isoform a [Homo sapiens]
          Length = 1093

 Score = 28.1 bits (61), Expect = 8.1
 Identities = 14/34 (41%), Positives = 18/34 (52%)

Query: 72  HGLALGLVIATLGNISGGHFNPAVSLAAMLIGGL 105
           HG  L LV+    NI G  FNP + + A L  G+
Sbjct: 612 HGRPLFLVLIREDNIRGSRFNPILDMLAALKKGI 645


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,950,036
Number of Sequences: 37866
Number of extensions: 423706
Number of successful extensions: 1207
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1152
Number of HSP's gapped (non-prelim): 28
length of query: 261
length of database: 18,247,518
effective HSP length: 100
effective length of query: 161
effective length of database: 14,460,918
effective search space: 2328207798
effective search space used: 2328207798
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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