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Search of human proteins with 4506929
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
(368 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 734 0.0
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 520 e-147
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] 488 e-138
gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens] 126 3e-29
gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens] 101 1e-21
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 79 5e-15
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 76 4e-14
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 76 4e-14
gi|54860079 nadrin isoform 1 [Homo sapiens] 70 3e-12
gi|54860105 nadrin isoform 2 [Homo sapiens] 70 3e-12
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 69 5e-12
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 69 5e-12
gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap... 69 5e-12
gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo sap... 69 5e-12
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 69 5e-12
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 67 2e-11
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 67 2e-11
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 67 2e-11
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 67 2e-11
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 67 2e-11
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 67 2e-11
gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo... 62 6e-10
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 62 8e-10
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 62 8e-10
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 61 2e-09
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 61 2e-09
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 61 2e-09
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 61 2e-09
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 61 2e-09
gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens] 60 3e-09
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 734 bits (1896), Expect = 0.0
Identities = 368/368 (100%), Positives = 368/368 (100%)
Query: 1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 60
MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
Sbjct: 1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 60
Query: 61 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES 120
NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
Sbjct: 61 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES 120
Query: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
Sbjct: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
Query: 181 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 240
EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
Sbjct: 181 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 240
Query: 241 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS 300
KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
Sbjct: 241 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS 300
Query: 301 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
Sbjct: 301 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
Query: 361 EVLVPLPQ 368
EVLVPLPQ
Sbjct: 361 EVLVPLPQ 368
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 520 bits (1338), Expect = e-147
Identities = 262/369 (71%), Positives = 305/369 (82%), Gaps = 20/369 (5%)
Query: 1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 60
MSVAGLKKQF+KA+Q VSEKVGGAEGTKLDDDFKEME+KVDVTS+AV E++ +TIEYLQP
Sbjct: 1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP 60
Query: 61 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES 120
NPASRAKL+M+NT+SKIRGQ K PGYPQ+E LL E M++ G+ELG + NFG AL + GE+
Sbjct: 61 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA 120
Query: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
M+ L+EVKDSLDIEVKQNFIDPLQNL +KDL+EIQHHLKKLEGRRLDFDYKKKRQGKIPD
Sbjct: 121 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
Query: 181 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 240
EELRQALEKF+ESKE+AE+SM NLLE DIEQVSQLSALV AQL+YH+QAVQIL ++ +L
Sbjct: 181 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL 240
Query: 241 KRRMREASSRPKREYKPKPRE--PFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT 298
+ R+R+ASS+P+REY+PKPR F G+ Q NGG T T
Sbjct: 241 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHT------------------GT 282
Query: 299 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 358
P S +DQP C+ALYDFEPEN+GELGF EGD+ITLTNQIDENWYEGML G SGFFP++
Sbjct: 283 PKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN 342
Query: 359 YVEVLVPLP 367
YVE+LV LP
Sbjct: 343 YVEILVALP 351
>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
Length = 347
Score = 488 bits (1257), Expect = e-138
Identities = 244/368 (66%), Positives = 290/368 (78%), Gaps = 21/368 (5%)
Query: 1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 60
MSVAGLKKQF+KASQL SEK+ GAEGTKLDD+F +ME+K+DVT+K V E+L++T EYLQP
Sbjct: 1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP 60
Query: 61 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES 120
NPA RAKL MLNTVSKIRGQVK GYPQ+EGLLG+CM+++GKELG +S FG+AL++ GES
Sbjct: 61 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES 120
Query: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
MK +AEVKDSLDI VKQ FIDPLQ L +KDLKEI HHLKKLEGRRLD+DYKKKR GKIPD
Sbjct: 121 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD 180
Query: 181 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 240
EE+RQA+EKFEESKE+AE SM N LE D+EQVSQL+ ++A LDYHRQ+ +IL EL KL
Sbjct: 181 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL 240
Query: 241 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS 300
+ R+ ASS P+REYKP+P + G T+ K S+
Sbjct: 241 QMRISAASSVPRREYKPRP-----VKRSSSELNGVSTTSVVKTTGSNI------------ 283
Query: 301 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
P+DQP C+ LYDFEPEN GELGF EGD+ITLTNQIDENWYEGM+ G+SGFFP++YV
Sbjct: 284 ----PMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYV 339
Query: 361 EVLVPLPQ 368
EV+VPLPQ
Sbjct: 340 EVIVPLPQ 347
>gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens]
Length = 365
Score = 126 bits (317), Expect = 3e-29
Identities = 98/367 (26%), Positives = 162/367 (44%), Gaps = 38/367 (10%)
Query: 12 KASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTML 71
+A Q EK+G AE T+LD + + K + T +++ +T LQPNP +R + +
Sbjct: 21 RAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVY 80
Query: 72 NTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKDSL 131
+ + K P + LLG+ MI G E G + +G+AL+ GE+ KR+ L
Sbjct: 81 EKLDR-----KAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADREL 135
Query: 132 DIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKI--------PDEEL 183
NF+ PL+N E D K I K L+ +RLD D K R K ++EL
Sbjct: 136 IQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQEL 195
Query: 184 RQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL-KR 242
R +F+ E+ + + T + L+ V+AQ+ Y+ Q Q + +L ++L
Sbjct: 196 RITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSF 255
Query: 243 RMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRS 302
S+ + P P + P SS+ S+ + T +
Sbjct: 256 PSNYLSNNNQTSVTPVP------------------SVLPNAIGSSAMASTSGLVITSPSN 297
Query: 303 MPPLDQPS----CKALYDFEPENDGELGFHEGDVITLTNQI--DENWYEGMLDGQSGFFP 356
+ L + S + LYD++ N EL +VIT+ + + D +W G Q G P
Sbjct: 298 LSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVP 357
Query: 357 LSYVEVL 363
++Y+E+L
Sbjct: 358 ITYLELL 364
>gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens]
Length = 395
Score = 101 bits (251), Expect = 1e-21
Identities = 95/400 (23%), Positives = 156/400 (39%), Gaps = 67/400 (16%)
Query: 10 FYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLT 69
F +A Q EK G AE T+LD F+ + + D T ++L +T LQPNP++R +
Sbjct: 16 FTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEF 75
Query: 70 MLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKD 129
+ + + K P + LL + M ELG + +G L+ E+ K+L +
Sbjct: 76 LYEKLDR-----KVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAER 130
Query: 130 SLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGK----------IP 179
+F+ PL+N E D K I + L+ RRLD D K R K +P
Sbjct: 131 DFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVP 190
Query: 180 D---------------------------EELRQALEKFEESKEVAETSMHNLLETDIEQV 212
D +ELR A +F+ EV + + T + +
Sbjct: 191 DFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHL 250
Query: 213 SQLSALVDAQLDYHRQAVQILDELAEKLKR------RMREASSRPKREYKPKPREPFDLG 266
L V +Q Y+ Q + + +L ++L R E +S P P
Sbjct: 251 RCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTSPTT------- 303
Query: 267 EPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLD-QPSCKALYDFEPENDGEL 325
T P + + +S + PP + LYD+E + EL
Sbjct: 304 ---------AAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSEL 354
Query: 326 GFHEGDVITLTN--QIDENWYEGMLDGQSGFFPLSYVEVL 363
++IT+ + +D +W G + G P++Y+E+L
Sbjct: 355 ALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 79.3 bits (194), Expect = 5e-15
Identities = 45/131 (34%), Positives = 68/131 (51%), Gaps = 26/131 (19%)
Query: 252 KREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT------------- 298
+R +KP P G CT A + +S+ S K +++
Sbjct: 78 QRPWKPGPG----------GGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWS 127
Query: 299 -PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPL 357
P R +P L P KALY++E + G+L F +GD+I L Q+DENWY G ++G GFFP
Sbjct: 128 PPVRGIPQL--PCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPT 185
Query: 358 SYVEVLVPLPQ 368
++V+++ PLPQ
Sbjct: 186 NFVQIIKPLPQ 196
Score = 61.6 bits (148), Expect = 1e-09
Identities = 32/61 (52%), Positives = 40/61 (65%), Gaps = 4/61 (6%)
Query: 305 PLDQPSCKALYDFE---PENDGE-LGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
P P CKALYDFE E D + L F + DV+T+ ++DENW EGML + G FP+SYV
Sbjct: 195 PQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYV 254
Query: 361 E 361
E
Sbjct: 255 E 255
Score = 42.0 bits (97), Expect = 9e-04
Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 21/111 (18%)
Query: 272 NGGFPCTTAPKIAA--------SSSFRSSDKPIRTPSR----SMPPLDQPS----C---K 312
+G P TTA AA +S S PI P R S+ P+ S C +
Sbjct: 776 DGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHR 835
Query: 313 ALYDFEPENDGELGFHEGDVITLTNQIDENWYEGML--DGQSGFFPLSYVE 361
+ + P+++ EL EGD++ + + ++ W++G L +G++G FP S+VE
Sbjct: 836 VVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 33.1 bits (74), Expect = 0.41
Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 3/59 (5%)
Query: 305 PLDQPSCK-ALYDFEPENDGELGFHEGDVITLTNQIDENWYEG--MLDGQSGFFPLSYV 360
P +PS A+Y + P + EL +G++ + + + W++G M + G FP +YV
Sbjct: 443 PQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 76.3 bits (186), Expect = 4e-14
Identities = 46/142 (32%), Positives = 70/142 (49%), Gaps = 5/142 (3%)
Query: 230 VQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSF 289
V++LD + ++ + S P R + P G + G P + AA+ S
Sbjct: 115 VRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGST 174
Query: 290 RSSDKPIRTPSRSMPPLDQPSC----KALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
S + + T SR+ P P KALY +E + G+L F++GD+I L ++DE WY
Sbjct: 175 AGSLRELAT-SRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYH 233
Query: 346 GMLDGQSGFFPLSYVEVLVPLP 367
G L G GF P SY++ + PLP
Sbjct: 234 GELHGTQGFLPASYIQCIQPLP 255
Score = 54.7 bits (130), Expect = 1e-07
Identities = 27/62 (43%), Positives = 39/62 (62%), Gaps = 4/62 (6%)
Query: 305 PLDQPSCKALYDFEPENDGE----LGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
P P KALYDFE ++ + L F + +++T+ ++DENW EGML + G FPL YV
Sbjct: 255 PHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYV 314
Query: 361 EV 362
E+
Sbjct: 315 EL 316
Score = 43.1 bits (100), Expect = 4e-04
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 10/99 (10%)
Query: 271 SNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEG 330
S+ G T P+ A+ S + TP + PL+ ALY ++P+ EL H+G
Sbjct: 437 SSAGSTPTAVPRAASVSGEQG------TPPKVQLPLNV--YLALYAYKPQKSDELELHKG 488
Query: 331 DVITLTNQIDENWYEG--MLDGQSGFFPLSYVEVLVPLP 367
++ + + + W++G + G SG FP +YV + +P
Sbjct: 489 EMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527
Score = 42.4 bits (98), Expect = 7e-04
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 13/84 (15%)
Query: 291 SSDKPIRTPSRSMPP-----------LDQPSCKALYDFEPENDGELGFHEGDVITLTNQI 339
S D +PSR P L + + + + P+++ E+ EGD++ + +
Sbjct: 797 SLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR 856
Query: 340 DENWYEGML--DGQSGFFPLSYVE 361
++ WY+G L +G++G FP S+VE
Sbjct: 857 EDGWYKGTLQRNGRTGLFPGSFVE 880
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 76.3 bits (186), Expect = 4e-14
Identities = 63/270 (23%), Positives = 123/270 (45%), Gaps = 43/270 (15%)
Query: 6 LKKQFYKASQLVSEKVGGAEGTK-LDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPAS 64
+KKQF + QL ++ VG AE T+ L +D ++EK++++ Q + ++
Sbjct: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVK--------------QVSHST 46
Query: 65 RAKLTMLNTVSKIRGQVKNPGYPQSEGL----LGECMIRHGKELGGESNFGDALLDAGES 120
KLT ++GQ +S+ L L +C++ LG ++ G L GE+
Sbjct: 47 HKKLTAC-----LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGET 101
Query: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKR------ 174
+LA+ +++V+++ I+PL L E ++ IQ K L LD D + R
Sbjct: 102 EDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSK 161
Query: 175 ----------QGKIPD---EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDA 221
G D EE+ +A + E ++ M++ + +I+ + L++
Sbjct: 162 SSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEV 221
Query: 222 QLDYHRQAVQILDELAEKLKRRMREASSRP 251
Q +YHR+++ +L + ++K + +P
Sbjct: 222 QAEYHRKSLTLLQAVLPQIKAQQEAWVEKP 251
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 70.1 bits (170), Expect = 3e-12
Identities = 60/264 (22%), Positives = 111/264 (42%), Gaps = 34/264 (12%)
Query: 6 LKKQFYKASQLVSEKVGGAEGTK-LDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPAS 64
+KKQF + QL ++ VG AE T+ L +D ++E+++D R + Q +
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
Query: 65 RAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRL 124
A+ Q Q E +S G L G++ +L
Sbjct: 61 DAERRHKKLPLTALAQNMQEASTQLE----------------DSLLGKMLETCGDAENQL 104
Query: 125 AEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGK------- 177
A ++ V++ +DPL + E ++ IQ K+L LD+D + R +
Sbjct: 105 ALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGT 164
Query: 178 ----IPD------EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHR 227
+P EE+ +A K E+ K+ M+N + + E L++AQ DYHR
Sbjct: 165 NFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHR 224
Query: 228 QAVQILDELAEKLKRRMREASSRP 251
+A+ +L++ +++ + + +P
Sbjct: 225 KALAVLEKTLPEMRAHQDKWAEKP 248
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 70.1 bits (170), Expect = 3e-12
Identities = 60/264 (22%), Positives = 111/264 (42%), Gaps = 34/264 (12%)
Query: 6 LKKQFYKASQLVSEKVGGAEGTK-LDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPAS 64
+KKQF + QL ++ VG AE T+ L +D ++E+++D R + Q +
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
Query: 65 RAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRL 124
A+ Q Q E +S G L G++ +L
Sbjct: 61 DAERRHKKLPLTALAQNMQEASTQLE----------------DSLLGKMLETCGDAENQL 104
Query: 125 AEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGK------- 177
A ++ V++ +DPL + E ++ IQ K+L LD+D + R +
Sbjct: 105 ALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGT 164
Query: 178 ----IPD------EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHR 227
+P EE+ +A K E+ K+ M+N + + E L++AQ DYHR
Sbjct: 165 NFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHR 224
Query: 228 QAVQILDELAEKLKRRMREASSRP 251
+A+ +L++ +++ + + +P
Sbjct: 225 KALAVLEKTLPEMRAHQDKWAEKP 248
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 69.3 bits (168), Expect = 5e-12
Identities = 51/173 (29%), Positives = 73/173 (42%), Gaps = 30/173 (17%)
Query: 223 LDYHRQAVQILDELAEKLKRRMREASS----RPKREYKPKPREPFDLGEPEQSN------ 272
L + R A + L+R M AS R +R+ +P P LG+ S
Sbjct: 142 LQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 201
Query: 273 ---GGFPCTTAPKIAASSSFRSSDKPIRTPS-----------------RSMPPLDQPSCK 312
G T ++S S S K +P R P ++ K
Sbjct: 202 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 261
Query: 313 ALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVP 365
A+YDF+ + EL F +GD + + +ID+NWYEG G+ G FP+SYVE L P
Sbjct: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 295 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 349
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 350 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 69.3 bits (168), Expect = 5e-12
Identities = 51/173 (29%), Positives = 73/173 (42%), Gaps = 30/173 (17%)
Query: 223 LDYHRQAVQILDELAEKLKRRMREASS----RPKREYKPKPREPFDLGEPEQSN------ 272
L + R A + L+R M AS R +R+ +P P LG+ S
Sbjct: 294 LQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 353
Query: 273 ---GGFPCTTAPKIAASSSFRSSDKPIRTPS-----------------RSMPPLDQPSCK 312
G T ++S S S K +P R P ++ K
Sbjct: 354 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 413
Query: 313 ALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVP 365
A+YDF+ + EL F +GD + + +ID+NWYEG G+ G FP+SYVE L P
Sbjct: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 447 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 501
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 502 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo
sapiens]
Length = 506
Score = 69.3 bits (168), Expect = 5e-12
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 10/202 (4%)
Query: 171 KKKRQGKIPDEELR--QALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQ 228
K++R+ + + LR + +EK + KE E + T ++ A +D +
Sbjct: 295 KERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNL 354
Query: 229 AVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNG------GFPCTTAPK 282
+ +L+ + KL + E RP+ + P F E E ++ F
Sbjct: 355 KLDLLEANSYKLSSMLAELEQRPQPSH-PCSNSIFRWREKEHTHSYVKISRPFLMKRLEN 413
Query: 283 IAASSSFRSSDKP-IRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDE 341
I + +S P TP+ L CKALY F+ D EL +GD++ + + +E
Sbjct: 414 IVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEE 473
Query: 342 NWYEGMLDGQSGFFPLSYVEVL 363
W+ G L+G+ G FP +YVE L
Sbjct: 474 GWWFGSLNGKKGHFPAAYVEEL 495
>gi|16418431 nitric oxide synthase trafficker isoform 1 [Homo
sapiens]
Length = 428
Score = 69.3 bits (168), Expect = 5e-12
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 10/202 (4%)
Query: 171 KKKRQGKIPDEELR--QALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQ 228
K++R+ + + LR + +EK + KE E + T ++ A +D +
Sbjct: 217 KERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNL 276
Query: 229 AVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNG------GFPCTTAPK 282
+ +L+ + KL + E RP+ + P F E E ++ F
Sbjct: 277 KLDLLEANSYKLSSMLAELEQRPQPSH-PCSNSIFRWREKEHTHSYVKISRPFLMKRLEN 335
Query: 283 IAASSSFRSSDKP-IRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDE 341
I + +S P TP+ L CKALY F+ D EL +GD++ + + +E
Sbjct: 336 IVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEE 395
Query: 342 NWYEGMLDGQSGFFPLSYVEVL 363
W+ G L+G+ G FP +YVE L
Sbjct: 396 GWWFGSLNGKKGHFPAAYVEEL 417
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 69.3 bits (168), Expect = 5e-12
Identities = 31/60 (51%), Positives = 43/60 (71%)
Query: 309 PSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLPQ 368
P KAL ++ +N G+L F++GD+I L Q+DENWY+G ++G SG FP S VEV+ LPQ
Sbjct: 128 PRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQ 187
Score = 53.5 bits (127), Expect = 3e-07
Identities = 26/63 (41%), Positives = 38/63 (60%), Gaps = 6/63 (9%)
Query: 305 PLDQPSCKALYDFE------PENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 358
P P C+ALY+F+ EN L F + D+IT+ +++DENW EG L + G FP+
Sbjct: 186 PQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPIL 245
Query: 359 YVE 361
+VE
Sbjct: 246 FVE 248
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 67.4 bits (163), Expect = 2e-11
Identities = 31/80 (38%), Positives = 45/80 (56%)
Query: 286 SSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
SS+ + R P ++ KA+YDF+ + EL F +GD + + +ID+NWYE
Sbjct: 747 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 806
Query: 346 GMLDGQSGFFPLSYVEVLVP 365
G G+ G FP+SYVE L P
Sbjct: 807 GEHHGRVGIFPISYVEKLTP 826
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 807 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 861
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 862 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 951 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 67.4 bits (163), Expect = 2e-11
Identities = 31/80 (38%), Positives = 45/80 (56%)
Query: 286 SSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
SS+ + R P ++ KA+YDF+ + EL F +GD + + +ID+NWYE
Sbjct: 567 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 626
Query: 346 GMLDGQSGFFPLSYVEVLVP 365
G G+ G FP+SYVE L P
Sbjct: 627 GEHHGRVGIFPISYVEKLTP 646
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 627 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 681
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 682 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 67.4 bits (163), Expect = 2e-11
Identities = 31/80 (38%), Positives = 45/80 (56%)
Query: 286 SSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
SS+ + R P ++ KA+YDF+ + EL F +GD + + +ID+NWYE
Sbjct: 404 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 463
Query: 346 GMLDGQSGFFPLSYVEVLVP 365
G G+ G FP+SYVE L P
Sbjct: 464 GEHHGRVGIFPISYVEKLTP 483
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 464 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 518
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 519 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 67.4 bits (163), Expect = 2e-11
Identities = 31/80 (38%), Positives = 45/80 (56%)
Query: 286 SSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
SS+ + R P ++ KA+YDF+ + EL F +GD + + +ID+NWYE
Sbjct: 474 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 533
Query: 346 GMLDGQSGFFPLSYVEVLVP 365
G G+ G FP+SYVE L P
Sbjct: 534 GEHHGRVGIFPISYVEKLTP 553
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 534 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 588
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 589 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 67.4 bits (163), Expect = 2e-11
Identities = 31/80 (38%), Positives = 45/80 (56%)
Query: 286 SSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
SS+ + R P ++ KA+YDF+ + EL F +GD + + +ID+NWYE
Sbjct: 843 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 902
Query: 346 GMLDGQSGFFPLSYVEVLVP 365
G G+ G FP+SYVE L P
Sbjct: 903 GEHHGRVGIFPISYVEKLTP 922
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 903 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 957
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 958 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 67.4 bits (163), Expect = 2e-11
Identities = 31/80 (38%), Positives = 45/80 (56%)
Query: 286 SSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYE 345
SS+ + R P ++ KA+YDF+ + EL F +GD + + +ID+NWYE
Sbjct: 409 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 468
Query: 346 GMLDGQSGFFPLSYVEVLVP 365
G G+ G FP+SYVE L P
Sbjct: 469 GEHHGRVGIFPISYVEKLTP 488
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 7/100 (7%)
Query: 266 GEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGEL 325
GE G FP + K+ + P R P + P + A Y+F + + EL
Sbjct: 469 GEHHGRVGIFPISYVEKLTPPEKAQ----PARPPPPAQPG-EIGEAIAKYNFNADTNVEL 523
Query: 326 GFHEGDVITLTNQIDENWYEGMLDG--QSGFFPLSYVEVL 363
+GD + L ++D+NWYEG + G + G FP+SYVEV+
Sbjct: 524 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 563
Score = 39.3 bits (90), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS--GFFPLSYVEVL 363
+ALY++ P N+ EL E DVI + + D+ W+ G G FP +YV+ L
Sbjct: 613 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo
sapiens]
Length = 323
Score = 62.4 bits (150), Expect = 6e-10
Identities = 44/137 (32%), Positives = 64/137 (46%), Gaps = 28/137 (20%)
Query: 231 QILDELAEKLK----RRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAAS 286
+ILD EK + R ++R +R+ K P L P+QS+
Sbjct: 205 EILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSA------------- 251
Query: 287 SSFRSSDKPIRTPSRSMPPLDQP-SCKALYDFEPENDGELGFHEGDVITLTNQIDE--NW 343
P++ S S L+QP ALY FE + G+L F GD IT+ ++ D +W
Sbjct: 252 --------PVQLNSGSQSNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDW 303
Query: 344 YEGMLDGQSGFFPLSYV 360
+EG L GQ+G FP +YV
Sbjct: 304 WEGKLRGQTGIFPANYV 320
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 62.0 bits (149), Expect = 8e-10
Identities = 25/49 (51%), Positives = 35/49 (71%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
+AL+DF+P+ DGELGF GD I + + D NW++G GQ+G FP +YV
Sbjct: 162 QALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 34/51 (66%), Gaps = 1/51 (1%)
Query: 313 ALYDFEPENDGELGFHEGDVITLTNQ-IDENWYEGMLDGQSGFFPLSYVEV 362
A YDF+ D EL F GD++ + N+ D+NWY+ L+G+ GF P +Y+E+
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEM 55
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 62.0 bits (149), Expect = 8e-10
Identities = 25/49 (51%), Positives = 35/49 (71%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
+AL+DF+P+ DGELGF GD I + + D NW++G GQ+G FP +YV
Sbjct: 121 QALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 169
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 34/51 (66%), Gaps = 1/51 (1%)
Query: 313 ALYDFEPENDGELGFHEGDVITLTNQ-IDENWYEGMLDGQSGFFPLSYVEV 362
A YDF+ D EL F GD++ + N+ D+NWY+ L+G+ GF P +Y+E+
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEM 55
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 60.8 bits (146), Expect = 2e-09
Identities = 30/75 (40%), Positives = 46/75 (61%), Gaps = 7/75 (9%)
Query: 298 TPSRSMPPLDQPS-----CKALYDFEPENDGELGFHEGDVITLTNQ--IDENWYEGMLDG 350
TP S +D + CK ++ +E +ND EL EGD++TL N+ ID W+EG L+G
Sbjct: 217 TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG 276
Query: 351 QSGFFPLSYVEVLVP 365
+ G FP ++V++L P
Sbjct: 277 RRGVFPDNFVKLLPP 291
Score = 58.5 bits (140), Expect = 9e-09
Identities = 25/82 (30%), Positives = 50/82 (60%), Gaps = 2/82 (2%)
Query: 282 KIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDE 341
++ + +S SS+ +RT R + C+ + + P+ND EL GD+I + +++E
Sbjct: 39 EVPSGNSLLSSETILRTNKRG--ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEE 96
Query: 342 NWYEGMLDGQSGFFPLSYVEVL 363
W+EG+L+G++G FP ++++ L
Sbjct: 97 GWWEGVLNGKTGMFPSNFIKEL 118
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 60.8 bits (146), Expect = 2e-09
Identities = 30/75 (40%), Positives = 46/75 (61%), Gaps = 7/75 (9%)
Query: 298 TPSRSMPPLDQPS-----CKALYDFEPENDGELGFHEGDVITLTNQ--IDENWYEGMLDG 350
TP S +D + CK ++ +E +ND EL EGD++TL N+ ID W+EG L+G
Sbjct: 254 TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG 313
Query: 351 QSGFFPLSYVEVLVP 365
+ G FP ++V++L P
Sbjct: 314 RRGVFPDNFVKLLPP 328
Score = 58.5 bits (140), Expect = 9e-09
Identities = 25/82 (30%), Positives = 50/82 (60%), Gaps = 2/82 (2%)
Query: 282 KIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDE 341
++ + +S SS+ +RT R + C+ + + P+ND EL GD+I + +++E
Sbjct: 76 EVPSGNSLLSSETILRTNKRG--ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEE 133
Query: 342 NWYEGMLDGQSGFFPLSYVEVL 363
W+EG+L+G++G FP ++++ L
Sbjct: 134 GWWEGVLNGKTGMFPSNFIKEL 155
Score = 42.7 bits (99), Expect = 5e-04
Identities = 16/46 (34%), Positives = 30/46 (65%)
Query: 315 YDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
+D++ ++D EL G++IT + D W+EG ++G+ G FP ++V
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV 53
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 60.8 bits (146), Expect = 2e-09
Identities = 26/52 (50%), Positives = 35/52 (67%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVL 363
KALYDF EN+ EL F GD+IT +D++W G L G+SG FP +Y++ L
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 56.6 bits (135), Expect = 3e-08
Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 2/72 (2%)
Query: 299 PSRSMPPLDQ--PSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFP 356
PS + P+D P L+DF E +L G+++ L +ID +WY G Q G FP
Sbjct: 427 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486
Query: 357 LSYVEVLVPLPQ 368
+YV+V++ +P+
Sbjct: 487 ANYVKVIIDIPE 498
Score = 49.7 bits (117), Expect = 4e-06
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 311 CKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLP 367
C A +++ E EL F EG++I L ++E W G + G++G FPL++VE + P
Sbjct: 517 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 573
Score = 45.1 bits (105), Expect = 1e-04
Identities = 28/110 (25%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 261 EPFDLGEPEQSNGGFPCTTAPKI----AASSSFRSSDKPIRTPSRSMPPLDQPS------ 310
E + GE G FP + + ++ S+ P++T Q +
Sbjct: 547 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 606
Query: 311 CKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
C+AL+ F E +L F GD I + ++D +W G L + G FP +V
Sbjct: 607 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 656
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 60.8 bits (146), Expect = 2e-09
Identities = 26/52 (50%), Positives = 35/52 (67%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVL 363
KALYDF EN+ EL F GD+IT +D++W G L G+SG FP +Y++ L
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 56.6 bits (135), Expect = 3e-08
Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 2/72 (2%)
Query: 299 PSRSMPPLDQ--PSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFP 356
PS + P+D P L+DF E +L G+++ L +ID +WY G Q G FP
Sbjct: 463 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522
Query: 357 LSYVEVLVPLPQ 368
+YV+V++ +P+
Sbjct: 523 ANYVKVIIDIPE 534
Score = 49.7 bits (117), Expect = 4e-06
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 311 CKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLP 367
C A +++ E EL F EG++I L ++E W G + G++G FPL++VE + P
Sbjct: 553 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 609
Score = 45.1 bits (105), Expect = 1e-04
Identities = 28/110 (25%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 261 EPFDLGEPEQSNGGFPCTTAPKI----AASSSFRSSDKPIRTPSRSMPPLDQPS------ 310
E + GE G FP + + ++ S+ P++T Q +
Sbjct: 583 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 642
Query: 311 CKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
C+AL+ F E +L F GD I + ++D +W G L + G FP +V
Sbjct: 643 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 692
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 60.8 bits (146), Expect = 2e-09
Identities = 26/52 (50%), Positives = 35/52 (67%)
Query: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVL 363
KALYDF EN+ EL F GD+IT +D++W G L G+SG FP +Y++ L
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 56.6 bits (135), Expect = 3e-08
Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 2/72 (2%)
Query: 299 PSRSMPPLDQ--PSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFP 356
PS + P+D P L+DF E +L G+++ L +ID +WY G Q G FP
Sbjct: 486 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545
Query: 357 LSYVEVLVPLPQ 368
+YV+V++ +P+
Sbjct: 546 ANYVKVIIDIPE 557
Score = 49.7 bits (117), Expect = 4e-06
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 311 CKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLP 367
C A +++ E EL F EG++I L ++E W G + G++G FPL++VE + P
Sbjct: 576 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 632
Score = 45.1 bits (105), Expect = 1e-04
Identities = 28/110 (25%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 261 EPFDLGEPEQSNGGFPCTTAPKI----AASSSFRSSDKPIRTPSRSMPPLDQPS------ 310
E + GE G FP + + ++ S+ P++T Q +
Sbjct: 606 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 665
Query: 311 CKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
C+AL+ F E +L F GD I + ++D +W G L + G FP +V
Sbjct: 666 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 715
Score = 36.2 bits (82), Expect = 0.048
Identities = 34/131 (25%), Positives = 55/131 (41%), Gaps = 15/131 (11%)
Query: 247 ASSRPKREYKPKPREPFDLG-EPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPP 305
+++R + P R D+ + +QSN T A S F++ D + P R P
Sbjct: 353 SATRRSNKKLPFNRSSSDMDLQKKQSN----LATGLSKAKSQVFKNQDPVL--PPRPKPG 406
Query: 306 --------LDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPL 357
L P A D +N GEL GDV+ + Q + N+ E +G L
Sbjct: 407 HPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHL 466
Query: 358 SYVEVLVPLPQ 368
S ++++ PL +
Sbjct: 467 SQMKIITPLDE 477
>gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens]
Length = 339
Score = 60.1 bits (144), Expect = 3e-09
Identities = 28/75 (37%), Positives = 45/75 (60%)
Query: 294 KPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSG 353
K + S+ + P +AL+DF + EL F GDVI L ++I+++W EG + G +G
Sbjct: 158 KSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATG 217
Query: 354 FFPLSYVEVLVPLPQ 368
FPLS+V++L P+
Sbjct: 218 IFPLSFVKILKDFPE 232
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.132 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,148,172
Number of Sequences: 37866
Number of extensions: 689151
Number of successful extensions: 3345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 259
Number of HSP's that attempted gapping in prelim test: 2776
Number of HSP's gapped (non-prelim): 738
length of query: 368
length of database: 18,247,518
effective HSP length: 104
effective length of query: 264
effective length of database: 14,309,454
effective search space: 3777695856
effective search space used: 3777695856
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.