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Search of human proteins with 4506815
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1
[Homo sapiens]
(669 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 1406 0.0
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 1406 0.0
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 1406 0.0
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 449 e-126
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 449 e-126
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 380 e-105
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 344 1e-94
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 149 1e-35
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 148 1e-35
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 143 4e-34
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 132 1e-30
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 130 4e-30
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 126 6e-29
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 122 8e-28
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 117 3e-26
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 106 6e-23
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 98 2e-20
gi|239755724 PREDICTED: hypothetical protein [Homo sapiens] 48 3e-05
gi|148727370 immediate early response 5-like [Homo sapiens] 44 6e-04
gi|110832843 TBP-associated factor 4 [Homo sapiens] 42 0.002
gi|19924099 synapsin I isoform Ia [Homo sapiens] 41 0.003
gi|19924097 synapsin I isoform Ib [Homo sapiens] 41 0.003
gi|47132519 Ras association and pleckstrin homology domains 1 is... 41 0.004
gi|46409434 hypothetical protein LOC388759 [Homo sapiens] 40 0.007
gi|126116581 retina and anterior neural fold homeobox [Homo sapi... 39 0.012
gi|239754489 PREDICTED: hypothetical protein [Homo sapiens] 38 0.035
gi|239743069 PREDICTED: hypothetical protein XP_002342750 [Homo ... 38 0.035
gi|239508715 PREDICTED: hypothetical protein [Homo sapiens] 38 0.035
gi|169167066 PREDICTED: hypothetical protein [Homo sapiens] 37 0.045
gi|113416187 PREDICTED: hypothetical protein [Homo sapiens] 37 0.045
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 1406 bits (3639), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 60
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
Sbjct: 60 MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 119
Query: 61 FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 120
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
Sbjct: 120 FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 179
Query: 121 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 180
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
Sbjct: 180 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 239
Query: 181 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 240
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
Sbjct: 240 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 299
Query: 241 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 300
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
Sbjct: 300 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 359
Query: 301 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 360
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
Sbjct: 360 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 419
Query: 361 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 420
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
Sbjct: 420 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 479
Query: 421 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 480
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
Sbjct: 480 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 539
Query: 481 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 540
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
Sbjct: 540 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 599
Query: 541 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 600
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
Sbjct: 600 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 659
Query: 601 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 660
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
Sbjct: 660 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 719
Query: 661 SSTCPLGGP 669
SSTCPLGGP
Sbjct: 720 SSTCPLGGP 728
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 1406 bits (3639), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 60
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
Sbjct: 24 MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 83
Query: 61 FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 120
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
Sbjct: 84 FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 143
Query: 121 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 180
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
Sbjct: 144 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 203
Query: 181 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 240
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
Sbjct: 204 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 263
Query: 241 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 300
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
Sbjct: 264 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 323
Query: 301 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 360
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
Sbjct: 324 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 383
Query: 361 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 420
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
Sbjct: 384 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 443
Query: 421 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 480
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
Sbjct: 444 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 503
Query: 481 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 540
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
Sbjct: 504 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 563
Query: 541 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 600
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
Sbjct: 564 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 623
Query: 601 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 660
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
Sbjct: 624 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 683
Query: 661 SSTCPLGGP 669
SSTCPLGGP
Sbjct: 684 SSTCPLGGP 692
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 1406 bits (3639), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 60
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
Sbjct: 1 MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE 60
Query: 61 FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 120
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
Sbjct: 61 FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL 120
Query: 121 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 180
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
Sbjct: 121 NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL 180
Query: 181 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 240
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
Sbjct: 181 RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT 240
Query: 241 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 300
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
Sbjct: 241 YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP 300
Query: 301 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 360
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
Sbjct: 301 MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA 360
Query: 361 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 420
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
Sbjct: 361 FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC 420
Query: 421 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 480
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
Sbjct: 421 FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS 480
Query: 481 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 540
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
Sbjct: 481 VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP 540
Query: 541 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 600
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
Sbjct: 541 SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR 600
Query: 601 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 660
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
Sbjct: 601 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS 660
Query: 661 SSTCPLGGP 669
SSTCPLGGP
Sbjct: 661 SSTCPLGGP 669
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 449 bits (1155), Expect = e-126
Identities = 229/588 (38%), Positives = 338/588 (57%), Gaps = 31/588 (5%)
Query: 32 GPEPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAV 89
GP P+AP P E +E L+E S+REL FFC N TIHGAIRLVCS+ NR+KT W +
Sbjct: 32 GP-PSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 90
Query: 90 LWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEE 149
L L + WQ GLLF ++ PV + ++++S++ + P VT+C NP R + LE
Sbjct: 91 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL 150
Query: 150 LDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASS 209
LD + + LY + S+ R L T+P R PP H R R
Sbjct: 151 LDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQR 195
Query: 210 LRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPS 269
L + +V ++GF+LCN DCFY+ Y+SGV AV++WY FHY++IL+ LP
Sbjct: 196 LSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWED 250
Query: 270 LEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLS 329
G+F+ +C ++ + C + FHHP YG+CYT + +W + PGI +G+
Sbjct: 251 SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVG 305
Query: 330 LMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 389
L+LR EQ +PLLST+ G RVMVHG++ F+ F++RPG E +IS+R++ + RLG
Sbjct: 306 LVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGS 365
Query: 390 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 449
YG CT G V VE L+ + YT+Q C+ SCFQ+ M++ C C Y +P P EYC +
Sbjct: 366 PYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 425
Query: 450 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 509
H +WG+C+Y+L D + L C ++C +PC ++++LS G SRWPS S W L Q
Sbjct: 426 HPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQ 485
Query: 510 N-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 568
+ + +R+ +AK+NI ++ELNY++ E+P ++ LLS +GS SLWFG+SVLS++E
Sbjct: 486 GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 545
Query: 569 MAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 614
+ EL+ D + ++ RR R + W GA + + PP
Sbjct: 546 LLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 593
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 449 bits (1155), Expect = e-126
Identities = 229/588 (38%), Positives = 338/588 (57%), Gaps = 31/588 (5%)
Query: 32 GPEPAAPQQPTAE--EEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAV 89
GP P+AP P E +E L+E S+REL FFC N TIHGAIRLVCS+ NR+KT W +
Sbjct: 98 GP-PSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 156
Query: 90 LWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEE 149
L L + WQ GLLF ++ PV + ++++S++ + P VT+C NP R + LE
Sbjct: 157 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL 216
Query: 150 LDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASS 209
LD + + LY + S+ R L T+P R PP H R R
Sbjct: 217 LDEFARENIDSLYNVNL-------SKGRAALSATVP------RHEPPFHLDREIR--LQR 261
Query: 210 LRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPS 269
L + +V ++GF+LCN DCFY+ Y+SGV AV++WY FHY++IL+ LP
Sbjct: 262 LSHSGSRV-----RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWED 316
Query: 270 LEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLS 329
G+F+ +C ++ + C + FHHP YG+CYT + +W + PGI +G+
Sbjct: 317 SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVG 371
Query: 330 LMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 389
L+LR EQ +PLLST+ G RVMVHG++ F+ F++RPG E +IS+R++ + RLG
Sbjct: 372 LVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGS 431
Query: 390 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 449
YG CT G V VE L+ + YT+Q C+ SCFQ+ M++ C C Y +P P EYC +
Sbjct: 432 PYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 491
Query: 450 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 509
H +WG+C+Y+L D + L C ++C +PC ++++LS G SRWPS S W L Q
Sbjct: 492 HPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQ 551
Query: 510 N-NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 568
+ + +R+ +AK+NI ++ELNY++ E+P ++ LLS +GS SLWFG+SVLS++E
Sbjct: 552 GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 611
Query: 569 MAELVFDLLVIMFLMLLRRFRSRY--WSPGRGGRGAQEVASTLASSPP 614
+ EL+ D + ++ RR R + W GA + + PP
Sbjct: 612 LLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPP 659
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 380 bits (977), Expect = e-105
Identities = 211/611 (34%), Positives = 331/611 (54%), Gaps = 24/611 (3%)
Query: 56 RELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVS 115
+EL ++C NT HG R+V S+ R++ W L ++ WQ LL + Y VS
Sbjct: 26 KELMRWYCLNTNTHGCRRIVVSR-GRLRRLLWIGFTLTAVALILWQCALLVFSF--YTVS 82
Query: 116 LNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKY---------SS 166
++I ++ KL FPAVTIC +NPY+Y ++ L +L++ T + L LY + S
Sbjct: 83 VSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAES 142
Query: 167 FTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWK--I 224
+ ++ G + R R L Q + R R V S+ V + K +
Sbjct: 143 WNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVV 202
Query: 225 GFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRF 284
GFQLC+ + SDC T+SSG++A++EWY+ HY+NI++++P + + C F
Sbjct: 203 GFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFF 262
Query: 285 NQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLS 344
+ VSC+ N++ FHHPM+GNCYTFN++ N + +SM G GL ++L + ++ P L
Sbjct: 263 DGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLV 322
Query: 345 TVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVE 404
+ TGA+V++H QDE F++D G + + TSI M +L Y CT++GSDVP+
Sbjct: 323 SSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIR 382
Query: 405 NLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDF 464
N+Y + Y+ Q+C+HSCFQ M+++CGCA P P YC+Y++H +W YCYY+L F
Sbjct: 383 NIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAF 442
Query: 465 SSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN--GVA 522
+ LGC + C++ CS + L+ ++WPSV S++W+ +L+ VN K N +A
Sbjct: 443 VQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLA 502
Query: 523 KVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFL 582
K+ IF+K+LN ++ ESP+ ++ LLSN G Q LW SV+ V+E+ E+ F I F
Sbjct: 503 KLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFF----IDFF 558
Query: 583 MLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPP 642
++ R R W + A + A +P S +L + P + AL PP
Sbjct: 559 SIIAR---RQWQKAKEW-WAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPA 614
Query: 643 AYATLGPRPSP 653
+ P P
Sbjct: 615 LGTQVPGTPPP 625
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 344 bits (883), Expect = 1e-94
Identities = 198/624 (31%), Positives = 317/624 (50%), Gaps = 43/624 (6%)
Query: 54 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP 113
+Y+EL ++C+NT HG R++C K A W +L L ++ WQ+G+ Y S+
Sbjct: 21 TYKELLVWYCDNTNTHGPKRIICE--GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78
Query: 114 VSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAG 173
VS+++++ + FPAVTIC +P++Y +IK L++LD + E L + ++
Sbjct: 79 VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERI-----LAPELSH 133
Query: 174 SRSRRDLRGTL-------------PHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK 220
+ + R+L ++ PH L + H + S + + + +
Sbjct: 134 ANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAH------ 187
Query: 221 DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGN-FI 279
K+ +LC+ N++ C ++ ++S A+ EWY NI +++P+ +E G I
Sbjct: 188 GCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQ-ELVEMSYPGEQMI 246
Query: 280 FACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDF 339
AC F CN N++ +P YGNCY FN S+ PG GL L+L Q D+
Sbjct: 247 LACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 306
Query: 340 IPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGS 399
+P L++ G R+M+H Q F+ D G G ETSI + + L R+G Y CT NGS
Sbjct: 307 VPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGS 366
Query: 400 DVPVENLYP---SKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYC 456
+VPV+N Y + Y+ Q C+ SCFQ+ MI+ C C + YP P+ +YC+ R W +C
Sbjct: 367 EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHC 426
Query: 457 YYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVN- 515
Y LQ+ + C C++ C+ T Y+++ + WPS S++W+F +LS++ + + N
Sbjct: 427 YSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNI 485
Query: 516 -NKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 574
R G+ K+NI+F+E NY+T ES + +V LLSNLG Q+ W G SVL ++E E++
Sbjct: 486 TLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
Query: 575 D---LLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGP 631
D + +I + L + R R G VA + + F P S GP
Sbjct: 546 DFVWITIIKLVALAKSLRQRRAQASYAG-PPPTVAELVEAHTNFGFQPDTAPRS-PNTGP 603
Query: 632 APS----PALTAPPPAYATLGPRP 651
PS P PPP Y +L +P
Sbjct: 604 YPSEQALPIPGTPPPNYDSLRLQP 627
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 149 bits (375), Expect = 1e-35
Identities = 118/512 (23%), Positives = 220/512 (42%), Gaps = 88/512 (17%)
Query: 83 KTAFWAVLWLCTFGMMY-WQFGLLFGEYFSYPVSLNINLN-SDKLVFPAVTICTLNPYRY 140
+ A W + + +FG++ W L + S+P ++ S +L FPAVT+C NP R+
Sbjct: 85 RRALWVLAFCTSFGLLLSWSSNRLL-YWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRF 143
Query: 141 PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGA 200
P + + DLY + L+ +R+ R L
Sbjct: 144 PRLSKG-------------DLYYAGHWLGLLLPNRTARPL-------------------- 170
Query: 201 RRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL 260
V+ LR + P+ W F+L + H+ I
Sbjct: 171 -----VSELLRGDEPRRQWFRKLADFRLFLPPR---------------------HFEGIS 204
Query: 261 SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS 320
+ + L ED L +C++ C N+S YG CY FN + +++
Sbjct: 205 AAFMDRLGHQLEDML----LSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTT 259
Query: 321 MPG-INNGLSLMLRAEQNDFIPLLSTV------TGARVMVHGQDEPAFMDDGGFNLRPGV 373
+ G NGL +ML +Q++++P+ G +V +H Q EP F+ + GF + PG
Sbjct: 260 VKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGF 319
Query: 374 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAY 433
+T ++ +++ L L +G+C + + + +P Y+ C C +++ C C
Sbjct: 320 QTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-YSITACRIDCETRYIVENCNCRM 375
Query: 434 IFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRW 493
+ P + +C +H L + S++ C CR PC++T Y +
Sbjct: 376 VHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--CL--CRTPCNLTRYNKELSMVKI 429
Query: 494 PSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGS 553
PS TS +++ + ++ Y N + ++IFF+ LNY+T + + + LL ++G
Sbjct: 430 PSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEALNYETIEQKKAYEVAALLGDIGG 485
Query: 554 QWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 585
Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 486 QMGLFIGASILTILELFDYIYELIKEKLLDLL 517
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 148 bits (374), Expect = 1e-35
Identities = 121/534 (22%), Positives = 228/534 (42%), Gaps = 93/534 (17%)
Query: 60 EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN 119
+ F N +T+HG + ++ WAV ++ + G++ + YFSY ++
Sbjct: 18 QIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVD 77
Query: 120 -LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRR 178
+ + LVFPAVT+C LN + R + T DLY L+
Sbjct: 78 EVVAQSLVFPAVTLCNLNGF-------------RFSRLTTNDLYHAGELLALL------- 117
Query: 179 DLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFY 238
D+ +P P L P SV +LR + ++K +K
Sbjct: 118 DVNLQIPDP--HLADP----------SVLEALRQ---KANFKHYKPK------------- 149
Query: 239 QTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFH 298
+F + L R+ L + + C+F C +++
Sbjct: 150 --------------QFSMLEFLHRVGHDLKDM--------MLYCKFKGQECGHQDFTTVF 187
Query: 299 HPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAEQNDFIPLLSTV------TGARV 351
YG CY FN + ++++ G NGL +ML +Q++++P+ G +V
Sbjct: 188 -TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKV 246
Query: 352 MVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKY 411
+H Q EP F+ + GF + PG +T ++ +++ L L +G+C + + + +P Y
Sbjct: 247 QIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-Y 302
Query: 412 TQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGC 471
+ C C +++ C C + P + +C +H L + S++ C
Sbjct: 303 SITACRIDCETRYIVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--C 358
Query: 472 FTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKEL 531
CR PC++T Y + PS TS +++ + ++ Y N + ++IFF+ L
Sbjct: 359 L--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEAL 412
Query: 532 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 585
NY+T + + + LL ++G Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 413 NYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLL 466
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 143 bits (361), Expect = 4e-34
Identities = 114/419 (27%), Positives = 186/419 (44%), Gaps = 49/419 (11%)
Query: 274 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 332
+L + + CRF C N++ M G CYTFN + + L ++ G+ NGL +ML
Sbjct: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214
Query: 333 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 386
+Q +++P+ G RV +H Q+EP +D G + PG +T +S +++ L
Sbjct: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274
Query: 387 LGGDYGDCTK---------NGSDVPVENLYPS---KYTQQVCIHSCFQESMIKECGCAYI 434
L +GDC+ SD P+ + PS YT C +C + ++CGC +
Sbjct: 275 LPPPWGDCSSASLNPNYEPEPSD-PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMV 333
Query: 435 FYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWP 494
+ P +V C +++ + + + S C PC+ T Y R P
Sbjct: 334 Y--MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIP 385
Query: 495 SVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQ 554
S + ++ + L+R Y N V ++IFF+ LNY+T + + M LL ++G Q
Sbjct: 386 SRAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQ 441
Query: 555 WSLWFGSSVLSVVEMAELVFDLLVIMFL-MLLRRFRSRYWSPGRGGRGAQEVASTLASSP 613
L+ G+S+L+++E + D L +F +L F +R S + +
Sbjct: 442 MGLFIGASLLTILE----ILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQ 497
Query: 614 PSHFCPHPMSLSLSQ---PGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 669
H P +L S+ P P PSP L+ PP A ATL P + C LG P
Sbjct: 498 VPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP--------AVCVLGAP 548
Score = 35.4 bits (80), Expect = 0.17
Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 119
F +N ++HG + ++ WA + + +Q Y F + +L+
Sbjct: 20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78
Query: 120 LNSDKLVFPAVTICTLNPYR 139
S +L+FPAVT+C +NP R
Sbjct: 79 RESHRLIFPAVTLCNINPLR 98
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 132 bits (332), Expect = 1e-30
Identities = 106/397 (26%), Positives = 179/397 (45%), Gaps = 48/397 (12%)
Query: 274 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 332
+L + + CRF C N++ M G CYTFN + + L ++ G+ NGL +ML
Sbjct: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214
Query: 333 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 386
+Q +++P+ G RV +H Q+EP +D G + PG +T +S +++ L
Sbjct: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274
Query: 387 LGGDYGDCTK---------NGSDVPVENLYPS---KYTQQVCIHSCFQESMIKECGCAYI 434
L +GDC+ SD P+ + PS YT C +C + ++CGC +
Sbjct: 275 LPPPWGDCSSASLNPNYEPEPSD-PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMV 333
Query: 435 FYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWP 494
+ P +V C +++ + + + S C PC+ T Y R P
Sbjct: 334 Y--MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIP 385
Query: 495 SVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQ 554
S + ++ + L+R Y N V ++IFF+ LNY+T + + M LL ++G Q
Sbjct: 386 SRAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQ 441
Query: 555 WSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPP 614
L+ G+S+L+++E+ + + ++ FR + + +Q +ST +S P
Sbjct: 442 MGLFIGASLLTILEILDYLCEV-----------FRDKVLGYFWNRQHSQRHSSTNLTSHP 490
Query: 615 SHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRP 651
S C H SL L P P TA + PRP
Sbjct: 491 S-LCRHQDSLRLP---PHLLPCHTALDLLSVSSEPRP 523
Score = 35.4 bits (80), Expect = 0.17
Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 119
F +N ++HG + ++ WA + + +Q Y F + +L+
Sbjct: 20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78
Query: 120 LNSDKLVFPAVTICTLNPYR 139
S +L+FPAVT+C +NP R
Sbjct: 79 RESHRLIFPAVTLCNINPLR 98
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 130 bits (327), Expect = 4e-30
Identities = 99/380 (26%), Positives = 173/380 (45%), Gaps = 40/380 (10%)
Query: 274 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 332
+L + + CRF C N++ M G CYTFN + + L ++ G+ NGL +ML
Sbjct: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214
Query: 333 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 386
+Q +++P+ G RV +H Q+EP +D G + PG +T +S +++ L
Sbjct: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274
Query: 387 LGGDYGDCTK---------NGSDVPVENLYPS---KYTQQVCIHSCFQESMIKECGCAYI 434
L +GDC+ SD P+ + PS YT C +C + ++CGC +
Sbjct: 275 LPPPWGDCSSASLNPNYEPEPSD-PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMV 333
Query: 435 FYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWP 494
+ P +V C +++ + + + S C PC+ T Y R P
Sbjct: 334 Y--MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIP 385
Query: 495 SVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQ 554
S + ++ + L+R Y N V ++IFF+ LNY+T + + M LL ++G Q
Sbjct: 386 SRAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQ 441
Query: 555 WSLWFGSSVLSVVEMAELVFDLL--VIMFLMLLRRFRSRYWS-----PGRGGRGAQEVAS 607
L+ G+S+L+++E+ + + ++ ++ R+ R+ S G G Q
Sbjct: 442 MGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHL 501
Query: 608 TLASSPPSHFCPHPMSLSLS 627
+L PP+ C +LS S
Sbjct: 502 SLGPRPPTPPCAVTKTLSAS 521
Score = 35.4 bits (80), Expect = 0.17
Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 119
F +N ++HG + ++ WA + + +Q Y F + +L+
Sbjct: 20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78
Query: 120 LNSDKLVFPAVTICTLNPYR 139
S +L+FPAVT+C +NP R
Sbjct: 79 RESHRLIFPAVTLCNINPLR 98
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 126 bits (317), Expect = 6e-29
Identities = 76/308 (24%), Positives = 147/308 (47%), Gaps = 20/308 (6%)
Query: 277 NFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAE 335
+ + +C F C+ ++ YG CYTFN + + +M G NGL +ML +
Sbjct: 167 DMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQ 225
Query: 336 QNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 389
Q++++P+ S G +V +H QDEP F+D GF + PG +T ++ +++ L L
Sbjct: 226 QDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285
Query: 390 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 449
+G C D ++ + Y+ C C +++ C C + P + YC +
Sbjct: 286 PWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYCTPEQ 341
Query: 450 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 509
+ +DF + + C PC++T Y + PS S +++ + ++
Sbjct: 342 YKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKS 397
Query: 510 NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEM 569
Y N + ++IFF+ LNY+T + + + LL ++G Q L+ G+S+L+V+E+
Sbjct: 398 EQYIGEN----ILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLEL 453
Query: 570 AELVFDLL 577
+ ++++
Sbjct: 454 FDYAYEVI 461
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN-L 120
F +++T+HG + + +K A WA+ +L + ++ YF Y ++ +
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
Query: 121 NSDKLVFPAVTICTLNPYRYPEIKE 145
+ +L FPAVT+C LN +R+ ++ +
Sbjct: 81 AASQLTFPAVTLCNLNEFRFSQVSK 105
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 122 bits (307), Expect = 8e-28
Identities = 82/314 (26%), Positives = 149/314 (47%), Gaps = 30/314 (9%)
Query: 275 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 334
L + + +C F+ C+ +N+S + YG CYTFN S+L S G+ +GL +ML
Sbjct: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
Query: 335 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 388
+Q +++P+ S G RV +H Q+EP ++ GF + PG +T +S +++ L L
Sbjct: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
Query: 389 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 448
+G+C E S Y+ C C +E++++ C C + P + + C
Sbjct: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETI--CPPN 475
Query: 449 KHSSWGYCYYKLQVDFSSDHLG------CFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWV 502
Y D + D LG CF C PC++T Y R P+ S ++
Sbjct: 476 --------IYIECADHTLDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARYL 525
Query: 503 FQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSS 562
+ +R Y R +++FF+ L + + + + LL +LG Q L+ G+S
Sbjct: 526 ARKYNRNETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGAS 581
Query: 563 VLSVVEMAELVFDL 576
+L+++E+ + ++++
Sbjct: 582 ILTLLEILDYIYEV 595
Score = 37.0 bits (84), Expect = 0.059
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNIN 119
F + +T+HG R + ++ WA+ L + +Q L Y + P V+++
Sbjct: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
Query: 120 LNSDKLVFPAVTICTLNPYRYPEIKE 145
+ FPAVT+C +N +R+ + +
Sbjct: 232 APAPVAGFPAVTLCNINRFRHSALSD 257
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 117 bits (294), Expect = 3e-26
Identities = 77/308 (25%), Positives = 142/308 (46%), Gaps = 37/308 (12%)
Query: 275 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 334
L + + +C F+ C+ +N+S + YG CYTFN S+L S G+ +GL +ML
Sbjct: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
Query: 335 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 388
+Q +++P+ S G RV +H Q+EP ++ GF + PG +T +S +++ L L
Sbjct: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
Query: 389 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 448
+G+C E S Y+ C C +E++++ C C + P D
Sbjct: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP--------DSL 469
Query: 449 KHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSR 508
G C+ C PC++T Y R P+ S ++ + +R
Sbjct: 470 GGGPEGPCF-----------------CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNR 512
Query: 509 QNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 568
Y R +++FF+ L + + + + LL +LG Q L+ G+S+L+++E
Sbjct: 513 NETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLE 568
Query: 569 MAELVFDL 576
+ + ++++
Sbjct: 569 ILDYIYEV 576
Score = 37.0 bits (84), Expect = 0.059
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNIN 119
F + +T+HG R + ++ WA+ L + +Q L Y + P V+++
Sbjct: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
Query: 120 LNSDKLVFPAVTICTLNPYRYPEIKE 145
+ FPAVT+C +N +R+ + +
Sbjct: 232 APAPVAGFPAVTLCNINRFRHSALSD 257
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 106 bits (265), Expect = 6e-23
Identities = 69/282 (24%), Positives = 127/282 (45%), Gaps = 20/282 (7%)
Query: 277 NFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAE 335
+ + +C F C+ ++ YG CYTFN + + +M G NGL +ML +
Sbjct: 167 DMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQ 225
Query: 336 QNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 389
Q++++P+ S G +V +H QDEP F+D GF + PG +T ++ +++ L L
Sbjct: 226 QDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285
Query: 390 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 449
+G C D ++ + Y+ C C +++ C C + P + YC +
Sbjct: 286 PWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYCTPEQ 341
Query: 450 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 509
+ +DF + + C PC++T Y + PS S +++ + ++
Sbjct: 342 YKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKS 397
Query: 510 NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNL 551
Y N + ++IFF+ LNY+T + + + LL L
Sbjct: 398 EQYIGEN----ILVLDIFFEVLNYETIEQKKAYEIAGLLGEL 435
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN-L 120
F +++T+HG + + +K A WA+ +L + ++ YF Y ++ +
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
Query: 121 NSDKLVFPAVTICTLNPYRYPEIKE 145
+ +L FPAVT+C LN +R+ ++ +
Sbjct: 81 AASQLTFPAVTLCNLNEFRFSQVSK 105
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 98.2 bits (243), Expect = 2e-20
Identities = 79/324 (24%), Positives = 145/324 (44%), Gaps = 28/324 (8%)
Query: 282 CRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINN-GLSLMLRAEQNDFI 340
C F C+ +++H YGNC+TFN + L ++ GLSL+ Q F
Sbjct: 185 CEFFGKPCSPKDFAHVFTE-YGNCFTFN--HGETLQAKRKVSVSGRGLSLLFNVNQEAFT 241
Query: 341 --PLLSTV-TGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKN 397
P L V G ++H + D G G+ +++R+ +G+C N
Sbjct: 242 DNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN 301
Query: 398 GSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSW---- 453
+ ++N S Y+ C+ C + + K+CGC P +E CD +K+ S
Sbjct: 302 ---IKLQNF--SSYSTSGCLKECKAQHIKKQCGCVPFLLPG-YGIE-CDLQKYFSCVSPV 354
Query: 454 -GYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNY 512
+ +K + + C C + Y + YS +PS + +++ + L++ Y
Sbjct: 355 LDHIEFKDLCTVGTHNSSCPVSCEE----IEYPATISYSSFPSQKALKYLSKKLNQSRKY 410
Query: 513 TVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 572
R + K+ I + +LNYK + +V++ LL++LG Q L+ G+S+++++E+ E
Sbjct: 411 I----RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY 466
Query: 573 VF-DLLVIMFLMLLRRFRSRYWSP 595
+F + I LL+ W+P
Sbjct: 467 LFTNFYWICIFFLLKISEMTQWTP 490
Score = 47.8 bits (112), Expect = 3e-05
Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Query: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 121
F +T+ HG I + ++++ W V+ L + ++ WQ + YF++P + +I +
Sbjct: 41 FAISTSFHG-IHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
Query: 122 -SDKLVFPAVTICTLNPYR 139
+K+ FPAVT C LN ++
Sbjct: 100 YVEKMEFPAVTFCNLNRFQ 118
>gi|239755724 PREDICTED: hypothetical protein [Homo sapiens]
Length = 481
Score = 47.8 bits (112), Expect = 3e-05
Identities = 20/22 (90%), Positives = 21/22 (95%)
Query: 229 CNQNKSDCFYQTYSSGVDAVRE 250
CNQNKSDCFYQTYSSGVDA R+
Sbjct: 215 CNQNKSDCFYQTYSSGVDAGRQ 236
>gi|148727370 immediate early response 5-like [Homo sapiens]
Length = 404
Score = 43.5 bits (101), Expect = 6e-04
Identities = 31/81 (38%), Positives = 37/81 (45%), Gaps = 10/81 (12%)
Query: 598 GGRGAQEVASTLASSPPSHFCPHP-MSLSLSQPGPAPSPALTAPPPAYATLGPR------ 650
GG GA A+ P H PH L QPGPAP P L PPPA A L PR
Sbjct: 148 GGAGALSELPGCAALQPPHGAPHRGQPLEPLQPGPAPLP-LPLPPPAPAALCPRDPRAPA 206
Query: 651 --PSPGGSAGASSSTCPLGGP 669
+P G+A +++ P P
Sbjct: 207 ACSAPPGAAPPAAAASPPASP 227
>gi|110832843 TBP-associated factor 4 [Homo sapiens]
Length = 1085
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/80 (35%), Positives = 38/80 (47%), Gaps = 13/80 (16%)
Query: 601 GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSP------- 653
GA + A SPP+ P P + + + P P P+PA A PP + P +P
Sbjct: 245 GAAAPPAPAAPSPPA--APAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAA 302
Query: 654 ---GGSAGASSSTCP-LGGP 669
GGSAGA+ + P GGP
Sbjct: 303 AQNGGSAGAAPAPAPAAGGP 322
Score = 35.4 bits (80), Expect = 0.17
Identities = 27/66 (40%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 594 SPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSP 653
SP R + A A TLA+S P+ M + + G PSPA PPPA T P P
Sbjct: 346 SPKRVVQAAPPAAQTLAASGPASTAAS-MVIGPTMQGALPSPA-AVPPPAPGT--PTGLP 401
Query: 654 GGSAGA 659
G+AGA
Sbjct: 402 KGAAGA 407
Score = 34.7 bits (78), Expect = 0.29
Identities = 22/68 (32%), Positives = 28/68 (41%), Gaps = 8/68 (11%)
Query: 606 ASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLG--------PRPSPGGSA 657
A+ A+ PP P ++ P P+ A PPPA A G P P+ GG A
Sbjct: 264 AAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPA 323
Query: 658 GASSSTCP 665
G S P
Sbjct: 324 GVSGQPGP 331
Score = 29.6 bits (65), Expect = 9.4
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 3/62 (4%)
Query: 598 GGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATL--GPRPSPGG 655
GG G Q P P P + L +P P S AP PA A + GP P+P G
Sbjct: 98 GGGGPQRPGPPSPRRPLVPAGPAPPAAKL-RPPPEGSAGSCAPVPAAAAVAAGPEPAPAG 156
Query: 656 SA 657
A
Sbjct: 157 PA 158
>gi|19924099 synapsin I isoform Ia [Homo sapiens]
Length = 705
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/111 (30%), Positives = 40/111 (36%), Gaps = 17/111 (15%)
Query: 568 EMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTL---------ASSPPSHFC 618
E +L+ +L+V L R R R SPGRG G L + PP+
Sbjct: 401 EDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQR 460
Query: 619 PHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 669
P P P P P P PP L RP P G S P G P
Sbjct: 461 PPPQG---GPPQPGPGPQRQGPP-----LQQRPPPQGQQHLSGLGPPAGSP 503
Score = 38.5 bits (88), Expect = 0.020
Identities = 28/80 (35%), Positives = 31/80 (38%), Gaps = 1/80 (1%)
Query: 589 RSRYWSPGRGGRGAQEVASTLAS-SPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATL 647
+ R P GG GA A AS SP P + S GPAP A APP
Sbjct: 529 QGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQ 588
Query: 648 GPRPSPGGSAGASSSTCPLG 667
GP P G AG + G
Sbjct: 589 GPPQKPPGPAGPTRQASQAG 608
Score = 30.8 bits (68), Expect = 4.2
Identities = 25/69 (36%), Positives = 28/69 (40%), Gaps = 15/69 (21%)
Query: 595 PGRGG--RGAQEVASTLASSPPSHFCPHPMSLSLSQPGPA--PSPALT------APPPAY 644
PG G R A + + PP+ P P S PGPA P P L PPPA
Sbjct: 595 PGPAGPTRQASQAGPVPRTGPPTTQQPRP-----SGPGPAGRPKPQLAQKPSQDVPPPAT 649
Query: 645 ATLGPRPSP 653
A G P P
Sbjct: 650 AAAGGPPHP 658
>gi|19924097 synapsin I isoform Ib [Homo sapiens]
Length = 669
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/111 (30%), Positives = 40/111 (36%), Gaps = 17/111 (15%)
Query: 568 EMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTL---------ASSPPSHFC 618
E +L+ +L+V L R R R SPGRG G L + PP+
Sbjct: 401 EDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQR 460
Query: 619 PHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 669
P P P P P P PP L RP P G S P G P
Sbjct: 461 PPPQG---GPPQPGPGPQRQGPP-----LQQRPPPQGQQHLSGLGPPAGSP 503
Score = 38.5 bits (88), Expect = 0.020
Identities = 28/80 (35%), Positives = 31/80 (38%), Gaps = 1/80 (1%)
Query: 589 RSRYWSPGRGGRGAQEVASTLAS-SPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATL 647
+ R P GG GA A AS SP P + S GPAP A APP
Sbjct: 529 QGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQ 588
Query: 648 GPRPSPGGSAGASSSTCPLG 667
GP P G AG + G
Sbjct: 589 GPPQKPPGPAGPTRQASQAG 608
Score = 30.8 bits (68), Expect = 4.2
Identities = 25/69 (36%), Positives = 28/69 (40%), Gaps = 15/69 (21%)
Query: 595 PGRGG--RGAQEVASTLASSPPSHFCPHPMSLSLSQPGPA--PSPALT------APPPAY 644
PG G R A + + PP+ P P S PGPA P P L PPPA
Sbjct: 595 PGPAGPTRQASQAGPVPRTGPPTTQQPRP-----SGPGPAGRPKPQLAQKPSQDVPPPAT 649
Query: 645 ATLGPRPSP 653
A G P P
Sbjct: 650 AAAGGPPHP 658
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/50 (42%), Positives = 22/50 (44%)
Query: 613 PPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSS 662
P F P P SL P P PSP PPP T P P GS G +S
Sbjct: 912 PSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTS 961
>gi|46409434 hypothetical protein LOC388759 [Homo sapiens]
Length = 237
Score = 40.0 bits (92), Expect = 0.007
Identities = 34/92 (36%), Positives = 44/92 (47%), Gaps = 16/92 (17%)
Query: 582 LMLLRRFRSRYWSPGRGGRG---AQEVASTLASSPPSHFCPHPMSLSLSQ-----PGPAP 633
++LL+ S W+ GRG RG + A++ + S SL + P P P
Sbjct: 76 VLLLQPEPSLTWAQGRGCRGHFRSLPAAASRSGSRTLRCASSDRSLREQKQRRAGPDPTP 135
Query: 634 SPALTAPPPAYATLGPRPSPGGSAGASSSTCP 665
SPA PPPA GPRPSP GS G S+ P
Sbjct: 136 SPA---PPPA----GPRPSP-GSLGPSAPAAP 159
>gi|126116581 retina and anterior neural fold homeobox [Homo
sapiens]
Length = 346
Score = 39.3 bits (90), Expect = 0.012
Identities = 27/73 (36%), Positives = 32/73 (43%), Gaps = 4/73 (5%)
Query: 597 RGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGP---RPSP 653
RG RGA+E L + P P S P PAP+P AP P Y P RPSP
Sbjct: 55 RGARGAKERDRRLGARPACPKAPEEGSEPSPPPAPAPAPEYEAPRP-YCPKEPGEARPSP 113
Query: 654 GGSAGASSSTCPL 666
G G ++ L
Sbjct: 114 GLPVGPATGEAKL 126
>gi|239754489 PREDICTED: hypothetical protein [Homo sapiens]
Length = 228
Score = 37.7 bits (86), Expect = 0.035
Identities = 33/84 (39%), Positives = 37/84 (44%), Gaps = 13/84 (15%)
Query: 585 LRRFRSRYWSPGRGGRGAQEVAST------LASSPPSHFCPHPMSLSLSQPGPAPSPALT 638
LRR R + GRGGRGA S P+H P L++P PS A
Sbjct: 124 LRRRRLQRRRGGRGGRGAGRARKPGPDRAGAERSLPAHRAPR-----LARPPVPPSVAHV 178
Query: 639 APPPAYATLGPRPSPGGSAGASSS 662
A A A LG RP PGG AG S
Sbjct: 179 AR--ASAGLGARPVPGGPAGPRES 200
>gi|239743069 PREDICTED: hypothetical protein XP_002342750 [Homo
sapiens]
Length = 231
Score = 37.7 bits (86), Expect = 0.035
Identities = 33/84 (39%), Positives = 37/84 (44%), Gaps = 13/84 (15%)
Query: 585 LRRFRSRYWSPGRGGRGAQEVAST------LASSPPSHFCPHPMSLSLSQPGPAPSPALT 638
LRR R + GRGGRGA S P+H P L++P PS A
Sbjct: 127 LRRRRLQRRRGGRGGRGAGRARKPGPDRAGAERSLPAHRAPR-----LARPPVPPSVAHV 181
Query: 639 APPPAYATLGPRPSPGGSAGASSS 662
A A A LG RP PGG AG S
Sbjct: 182 AR--ASAGLGARPVPGGPAGPRES 203
>gi|239508715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 231
Score = 37.7 bits (86), Expect = 0.035
Identities = 33/84 (39%), Positives = 37/84 (44%), Gaps = 13/84 (15%)
Query: 585 LRRFRSRYWSPGRGGRGAQEVAST------LASSPPSHFCPHPMSLSLSQPGPAPSPALT 638
LRR R + GRGGRGA S P+H P L++P PS A
Sbjct: 127 LRRRRLQRRRGGRGGRGAGRARKPGPDRAGAERSLPAHRAPR-----LARPPVPPSVAHV 181
Query: 639 APPPAYATLGPRPSPGGSAGASSS 662
A A A LG RP PGG AG S
Sbjct: 182 AR--ASAGLGARPVPGGPAGPRES 203
>gi|169167066 PREDICTED: hypothetical protein [Homo sapiens]
Length = 262
Score = 37.4 bits (85), Expect = 0.045
Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 1/73 (1%)
Query: 586 RRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYA 645
RR SR + GR + Q AS L P CP P+ L GPA P L P +
Sbjct: 77 RRSSSRSLARGRITQ-CQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGV 135
Query: 646 TLGPRPSPGGSAG 658
T RP G +G
Sbjct: 136 TFAGRPRLGQESG 148
>gi|113416187 PREDICTED: hypothetical protein [Homo sapiens]
Length = 262
Score = 37.4 bits (85), Expect = 0.045
Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 1/73 (1%)
Query: 586 RRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYA 645
RR SR + GR + Q AS L P CP P+ L GPA P L P +
Sbjct: 77 RRSSSRSLARGRITQ-CQVAASPLVPPPAPPHCPRPLLCFLPAAGPAGLPPLRTSPCSGV 135
Query: 646 TLGPRPSPGGSAG 658
T RP G +G
Sbjct: 136 TFAGRPRLGQESG 148
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,086,191
Number of Sequences: 37866
Number of extensions: 1606868
Number of successful extensions: 13094
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 313
Number of HSP's that attempted gapping in prelim test: 10700
Number of HSP's gapped (non-prelim): 2234
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.