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Search of human proteins with 4506439
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
(425 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 892 0.0
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 805 0.0
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 800 0.0
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 743 0.0
gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens] 145 9e-35
gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo sap... 145 9e-35
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] 123 4e-28
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 96 8e-20
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 92 1e-18
gi|21071067 TBP-associated factor 5 [Homo sapiens] 87 2e-17
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 81 2e-15
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 80 5e-15
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 79 8e-15
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 79 8e-15
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 79 8e-15
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 79 8e-15
gi|32189425 WD repeat domain 69 [Homo sapiens] 78 2e-14
gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo s... 73 6e-13
gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo... 73 6e-13
gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s... 73 6e-13
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 72 7e-13
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 72 7e-13
gi|4757988 WD repeat domain 39 [Homo sapiens] 72 7e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 72 1e-12
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 72 1e-12
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 72 1e-12
gi|109627650 coronin 6 [Homo sapiens] 71 2e-12
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 70 5e-12
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 69 6e-12
gi|113865883 WD repeat domain 38 [Homo sapiens] 68 1e-11
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 892 bits (2306), Expect = 0.0
Identities = 425/425 (100%), Positives = 425/425 (100%)
Query: 1 MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY 60
MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY
Sbjct: 1 MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY 60
Query: 61 ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI 120
ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI
Sbjct: 61 ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI 120
Query: 121 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 180
NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY
Sbjct: 121 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 180
Query: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES
Sbjct: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW
Sbjct: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360
DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED
Sbjct: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360
Query: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL 420
GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL
Sbjct: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL 420
Query: 421 EGQGS 425
EGQGS
Sbjct: 421 EGQGS 425
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 805 bits (2078), Expect = 0.0
Identities = 380/425 (89%), Positives = 403/425 (94%), Gaps = 1/425 (0%)
Query: 1 MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY 60
MA KE F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VT+PEGKD+
Sbjct: 1 MADKEAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDF 60
Query: 61 ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI 120
++H LVLGTHTSDEQNHLV+A V +PNDDAQFDASH DS+KGEFGGFGSV+GKIE EIKI
Sbjct: 61 SIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKI 120
Query: 121 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 180
NHEGEVNRARYMPQNP IIATKTPSSDVLVFDYTKHP+KPDPSGECNPDLRLRGHQKEGY
Sbjct: 121 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 180
Query: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
GLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK+VDAK IFTGH+AVVEDV+WHLLHES
Sbjct: 181 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 240
Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
LFGSVADDQKLMIWDTRSN TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVALW
Sbjct: 241 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360
DLRNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRLNVWDLSKIGEEQS EDAED
Sbjct: 301 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 360
Query: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL 420
GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ+WQMAENIYNDE+ + + +
Sbjct: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV-DP 419
Query: 421 EGQGS 425
EGQGS
Sbjct: 420 EGQGS 424
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 800 bits (2066), Expect = 0.0
Identities = 380/426 (89%), Positives = 403/426 (94%), Gaps = 2/426 (0%)
Query: 1 MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 59
MA KE F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VT+PEGKD
Sbjct: 1 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60
Query: 60 YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIK 119
+++H LVLGTHTSDEQNHLV+A V +PNDDAQFDASH DS+KGEFGGFGSV+GKIE EIK
Sbjct: 61 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120
Query: 120 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 179
INHEGEVNRARYMPQNP IIATKTPSSDVLVFDYTKHP+KPDPSGECNPDLRLRGHQKEG
Sbjct: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180
Query: 180 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 239
YGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK+VDAK IFTGH+AVVEDV+WHLLHE
Sbjct: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240
Query: 240 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 299
SLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVAL
Sbjct: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300
Query: 300 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 359
WDLRNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRLNVWDLSKIGEEQS EDAE
Sbjct: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360
Query: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSE 419
DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ+WQMAENIYNDE+ + + +
Sbjct: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV-D 419
Query: 420 LEGQGS 425
EGQGS
Sbjct: 420 PEGQGS 425
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 743 bits (1917), Expect = 0.0
Identities = 350/391 (89%), Positives = 372/391 (95%), Gaps = 1/391 (0%)
Query: 35 MTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDA 94
MTHAL+WPSLT QWLP+VT+PEGKD+++H LVLGTHTSDEQNHLV+A V +PNDDAQFDA
Sbjct: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
Query: 95 SHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYT 154
SH DS+KGEFGGFGSV+GKIE EIKINHEGEVNRARYMPQNP IIATKTPSSDVLVFDYT
Sbjct: 61 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120
Query: 155 KHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGK 214
KHP+KPDPSGECNPDLRLRGHQKEGYGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK
Sbjct: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180
Query: 215 IVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAE 274
+VDAK IFTGH+AVVEDV+WHLLHESLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAE
Sbjct: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240
Query: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILAS 334
VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH+FESHKDEIFQV WSPHNETILAS
Sbjct: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300
Query: 335 SGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 394
SGTDRRLNVWDLSKIGEEQS EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE
Sbjct: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360
Query: 395 DNIMQIWQMAENIYNDEESDVTTSELEGQGS 425
DNIMQ+WQMAENIYNDE+ + + + EGQGS
Sbjct: 361 DNIMQVWQMAENIYNDEDPEGSV-DPEGQGS 390
>gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens]
Length = 103
Score = 145 bits (365), Expect = 9e-35
Identities = 72/107 (67%), Positives = 83/107 (77%), Gaps = 5/107 (4%)
Query: 1 MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 59
M +KE F++ VEE VI EEYKIWK NT F YDLVMT AL+WPSLT QWLP+VT+PEGKD
Sbjct: 1 MTNKEAAFDNAVEEHVIKEEYKIWKNNTSFPYDLVMTQALEWPSLTAQWLPDVTRPEGKD 60
Query: 60 YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGG 106
++ H LV GTHTS EQNHL V +P+DDAQ DASH +S KGE GG
Sbjct: 61 FSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDASHYNSKKGECGG 103
>gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo
sapiens]
Length = 103
Score = 145 bits (365), Expect = 9e-35
Identities = 72/107 (67%), Positives = 83/107 (77%), Gaps = 5/107 (4%)
Query: 1 MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 59
M +KE F++ VEE VI EEYKIWK NT F YDLVMT AL+WPSLT QWLP+VT+PEGKD
Sbjct: 1 MTNKEAAFDNAVEEHVIKEEYKIWKNNTSFPYDLVMTQALEWPSLTAQWLPDVTRPEGKD 60
Query: 60 YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGG 106
++ H LV GTHTS EQNHL V +P+DDAQ DASH +S KGE GG
Sbjct: 61 FSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDASHYNSKKGECGG 103
>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
Length = 446
Score = 123 bits (308), Expect = 4e-28
Identities = 96/356 (26%), Positives = 160/356 (44%), Gaps = 35/356 (9%)
Query: 64 WLVLGTHTSDEQ-NHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIK-IN 121
+L GT Q N L++ R+H + + D ++ E K + E+ +
Sbjct: 88 YLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVP 147
Query: 122 HEGEVNRAR--YMPQNPHIIATKTPSSDVLVF------DYTKHPAK-----PDPSGECNP 168
H G +NR R ++ + P + + V VF + P D + P
Sbjct: 148 HYGGINRVRVSWLGEEP-VAGVWSEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKP 206
Query: 169 DLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKI--VDAKAIFTGHS 226
GH EG+ L W+ ++G LL+ + LW P +G VD + F GH+
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWT----PTDGGSWHVDQRP-FVGHT 261
Query: 227 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDA--HTAEVNCLSFNPYS 284
VED+ W ++F S + D + IWD R+ SK L A H +VN +S++
Sbjct: 262 RSVEDLQWSPTENTVFASCSADASIRIWDIRA-APSKACMLTTATAHDGDVNVISWSRRE 320
Query: 285 EFILATGSADKTVALWDLRNLKL--KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLN 342
F+L+ G D + +WDLR K + TF+ H + V W P + + A+SG D ++
Sbjct: 321 PFLLSGGD-DGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQIT 379
Query: 343 VWDLS-----KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 393
WDL+ + G+ ++ D P +LLF+H G T ++ + W+P P ++ S +
Sbjct: 380 QWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGET-ELKELHWHPQCPGLLVSTA 434
Score = 41.6 bits (96), Expect = 0.001
Identities = 25/95 (26%), Positives = 40/95 (42%), Gaps = 10/95 (10%)
Query: 309 LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFI 368
+ +F H E F + WSP L + + +++W + G D P +
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHV-----DQRPFV--- 258
Query: 369 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
GHT + D W+P E V S S D ++IW +
Sbjct: 259 --GHTRSVEDLQWSPTENTVFASCSADASIRIWDI 291
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 95.5 bits (236), Expect = 8e-20
Identities = 76/251 (30%), Positives = 122/251 (48%), Gaps = 31/251 (12%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
LRGH Y + ++ SG LLS S+D ++ WD+ + ++ GH+ V D
Sbjct: 338 LRGHCGPVYSTRFLADSSG-LLSCSEDMSIRYWDLGSFTNT-------VLYQGHAYPVWD 389
Query: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 291
+ + F S + D+ +W S + P + H A+V+C+ F+P S + LATG
Sbjct: 390 LDISP-YSLYFASGSHDRTARLW---SFDRTYPLRIYAGHLADVDCVKFHPNSNY-LATG 444
Query: 292 SADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGE 351
S DKTV LW + + F H+ + + +SP N LAS+G D+RL +WDL+
Sbjct: 445 STDKTVRLWSAQQGN-SVRLFTGHRGPVLSLAFSP-NGKYLASAGEDQRLKLWDLAS--- 499
Query: 352 EQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 411
L GHT I+ +++P + +I S S DN +++W + N Y
Sbjct: 500 -----------GTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDI-RNTYCSA 546
Query: 412 ESDVTTSELEG 422
+D ++SEL G
Sbjct: 547 PADGSSSELVG 557
Score = 28.9 bits (63), Expect = 9.3
Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 4/49 (8%)
Query: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVH 323
+N +P S+ +LA G + + LW LR+ KLK E H+ ++ ++H
Sbjct: 271 LNTAEISPDSK-LLAAGFDNSCIKLWSLRSKKLK---SEPHQVDVSRIH 315
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 91.7 bits (226), Expect = 1e-18
Identities = 71/271 (26%), Positives = 115/271 (42%), Gaps = 33/271 (12%)
Query: 135 NPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLL- 193
N H++ T + + ++D K P + H +E Y + W+ L+
Sbjct: 79 NEHVLITCSGDGSLQLWDTAK---------AAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129
Query: 194 SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMI 253
S S D TV LWD P GK + F GH +++ W F S + DQ L I
Sbjct: 130 SGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182
Query: 254 WDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFE 313
WD ++ + ++ AH AE+ + Y+E +L TG+ D ++ WDLRN++ +
Sbjct: 183 WDVKA---AGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELL 239
Query: 314 SHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHT 373
H I +V +SP + ++LAS D + W+ SK P LL HT
Sbjct: 240 GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK-------------PDSLLETVEHHT 286
Query: 374 AKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
++ P + S D ++I+ A
Sbjct: 287 EFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317
Score = 54.7 bits (130), Expect = 2e-07
Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 15/127 (11%)
Query: 278 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWS-PHNETILASSG 336
++++ +E +L T S D ++ LWD L ++ H E++ V WS E ++ S
Sbjct: 73 VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS 132
Query: 337 TDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 396
D+ + +WD +G+ L GH + I W+P+ P S S D
Sbjct: 133 WDQTVKLWD-PTVGKS-------------LCTFRGHESIIYSTIWSPHIPGCFASASGDQ 178
Query: 397 IMQIWQM 403
++IW +
Sbjct: 179 TLRIWDV 185
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/250 (29%), Positives = 116/250 (46%), Gaps = 36/250 (14%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
L GH YG S++ + + +LLS+S+D TV LW + + GH+ V D
Sbjct: 539 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSLQT-------FTCLVGYKGHNYPVWD 590
Query: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 291
+ + F S D+ +W T +P + H A+VNC F+P S ++ ATG
Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLWATDHY---QPLRIFAGHLADVNCTRFHPNSNYV-ATG 645
Query: 292 SADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS---K 348
SAD+TV LWD+ N + F HK I + +SP N LA+ TD R+ +WD+
Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 703
Query: 349 IGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIY 408
+GE + GHT + ++ + ++ S S DN +++W +
Sbjct: 704 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLWDAIKAFE 745
Query: 409 NDEESDVTTS 418
+ E D TT+
Sbjct: 746 DLETDDFTTA 755
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 80.9 bits (198), Expect = 2e-15
Identities = 52/174 (29%), Positives = 89/174 (51%), Gaps = 13/174 (7%)
Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSA 227
P + L GH + + W+ + + SAS DHT+ +WD+ +G K+ TG+
Sbjct: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298
Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
V +++ L + L S + D+ + +WD R+ S S + +HT V + ++P E
Sbjct: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357
Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341
L +GS D V LWD R+ K L+ +H+D++ V W+ + +L S G D +L
Sbjct: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409
Score = 58.9 bits (141), Expect = 8e-09
Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 47/254 (18%)
Query: 174 GHQKEGYGLSW--NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
GH ++W +LS LLSAS D T+ LW+ N E V A GH+ V+
Sbjct: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194
Query: 232 VAWHLLHESLFGSVADDQKLMIWDT-----------------------RSNTTSKPSHLV 268
+A + F S + D+ L IW T + T P +
Sbjct: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253
Query: 269 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQ-VHWSPH 327
H V+ + ++ E + + S D T+ +WD+ + LK T +K +F + +SP
Sbjct: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308
Query: 328 NETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 387
+ LAS TDR + +WD +DG L + HT ++ W+P
Sbjct: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356
Query: 388 VICSVSEDNIMQIW 401
+ S S DNI+++W
Sbjct: 357 QLISGSLDNIVKLW 370
Score = 56.2 bits (134), Expect = 5e-08
Identities = 44/170 (25%), Positives = 69/170 (40%), Gaps = 16/170 (9%)
Query: 223 TGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP 282
+GH V V W E S + D + +WD S + NC+S++P
Sbjct: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLKSTL----TGNKVFNCISYSP 307
Query: 283 YSEFILATGSADKTVALWDLRNLKLKLHTFE--SHKDEIFQVHWSPHNETILASSGTDRR 340
+ LA+GS D+ + LWD R L + SH + V WSP +E L S D
Sbjct: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366
Query: 341 LNVWD-------LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNP 383
+ +WD L + + + D L + GG K+ + ++P
Sbjct: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416
Score = 37.4 bits (85), Expect = 0.026
Identities = 33/134 (24%), Positives = 53/134 (39%), Gaps = 16/134 (11%)
Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHN--ETILASSGTDRRLN 342
E+IL TGS DKT +W L + T H D + V W + +L S+ D+ +
Sbjct: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168
Query: 343 VWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 402
+W+ + E + L GH + + + CS S D +++IW
Sbjct: 169 LWEW----------NVERNKVKALHCCRGHAGSVDSIAVD-GSGTKFCSGSWDKMLKIWS 217
Query: 403 MAENIYNDEESDVT 416
DE + T
Sbjct: 218 TVPTDEEDEMEEST 231
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 79.7 bits (195), Expect = 5e-15
Identities = 65/209 (31%), Positives = 92/209 (44%), Gaps = 26/209 (12%)
Query: 194 SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLF-GSVADDQKLM 252
+ SDD TV +WD +E I GH A V+ V WH + GS Q +
Sbjct: 219 TCSDDGTVRIWDFLRCHEE-------RILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIK 271
Query: 253 IWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTF 312
WD ++ + H AH V + N ++L T S D L+D+RNLK +L F
Sbjct: 272 FWDPKTGQSLATLH---AHKNTVMEVKLNLNGNWLL-TASRDHLCKLFDIRNLKEELQVF 327
Query: 313 ESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGH 372
HK E V W P +E + AS G+D L W +G E+ E G E+ H
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFW---HVGVEK-----EVGGMEM-----AH 374
Query: 373 TAKISDFSWNPNEPWVICSVSEDNIMQIW 401
I +W+P ++CS S D+ + W
Sbjct: 375 EGMIWSLAWHP-LGHILCSGSNDHTSKFW 402
Score = 52.0 bits (123), Expect = 1e-06
Identities = 46/234 (19%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
L+ H ++W+ N +L+A V W N ++ +F H + +
Sbjct: 157 LQAHDSPVRAMTWSHN-DMWMLTADHGGYVKYWQSN--------MNNVKMFQAHKEAIRE 207
Query: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 291
++ ++ F + +DD + IWD ++ H A+V C+ ++P ++ ++ +G
Sbjct: 208 ASFSPT-DNKFATCSDDGTVRIWDF---LRCHEERILRGHGADVKCVDWHP-TKGLVVSG 262
Query: 292 SAD--KTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
S D + + WD + + L T +HK+ + +V + + +L +S D ++D+ +
Sbjct: 263 SKDSQQPIKFWDPKTGQ-SLATLHAHKNTVMEVKLNLNGNWLLTAS-RDHLCKLFDIRNL 320
Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
EE L + GH + + +W+P + S D + W +
Sbjct: 321 KEE-------------LQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHV 361
Score = 35.0 bits (79), Expect = 0.13
Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 8/91 (8%)
Query: 173 RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDV 232
RGH+KE ++W+ G S D ++ W + + G + A H ++ +
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMA------HEGMIWSL 381
Query: 233 AWHLLHESLFGSVADDQKLMIWDTRSNTTSK 263
AWH L L S ++D W TR+ K
Sbjct: 382 AWHPLGHILC-SGSNDHTSKFW-TRNRPGDK 410
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 79.0 bits (193), Expect = 8e-15
Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
H+ + L WN ++LSA D T +WD + G +AK F HSA DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 328
Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
+ + F S + D + + + +P HT EVN + ++P S +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382
Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
T+ +W ++ ++ +H ++H EI+ + WSP ++ +LAS+ D + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441
Query: 347 SK 348
+
Sbjct: 442 ER 443
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
LRGH+ E + +WN +S L S S D T +W++N G ++V I G V
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
V + W+ + +L + + D IW N S + H + L +N
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290
Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345
Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
++G ++ + + GHT +++ W+P+ ++ S S+D ++IW M
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391
Query: 405 ENI 407
+ +
Sbjct: 392 QEV 394
Score = 53.1 bits (126), Expect = 5e-07
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)
Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
P +GH E + W+ SG LL S SDD T+ +W + +E I D +A H+
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 403
Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
+ + W + + S + D + +WD + H + H V +
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 460
Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
+F+P ++ LA+GS DK V +W+ ++ L +H++ IF+V W+ + + +S +D
Sbjct: 461 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 516
Query: 339 RRLNVWDLSK 348
+ V DL K
Sbjct: 517 GSVCVLDLRK 526
Score = 43.1 bits (100), Expect = 5e-04
Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)
Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
SV + K M D S + ++ H +EV ++NP S+ +LA+GS D T +W+L
Sbjct: 153 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 211
Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
+ +L L H S+KD + + W+ N T+LA+ D +W
Sbjct: 212 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 264
Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
EDG L G H I WN +++ S D IW
Sbjct: 265 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 305
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)
Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
K H+ E+F W+P ++ +LAS D +W+L+ E++ G +L+
Sbjct: 173 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 223
Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
H GGH ++ WN N ++ + S D +IW N+
Sbjct: 224 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 270
Score = 36.2 bits (82), Expect = 0.058
Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)
Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
K DPSG C+ D+ L+ H KE Y + W N N + L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
SAS D TV LWDI G T H V VA+ + L S + D+ +
Sbjct: 428 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479
Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
IW+T+S +LV ++ T + + +N + + A+ S D +V + DLR
Sbjct: 480 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 79.0 bits (193), Expect = 8e-15
Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
H+ + L WN ++LSA D T +WD + G +AK F HSA DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 328
Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
+ + F S + D + + + +P HT EVN + ++P S +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382
Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
T+ +W ++ ++ +H ++H EI+ + WSP ++ +LAS+ D + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441
Query: 347 SK 348
+
Sbjct: 442 ER 443
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
LRGH+ E + +WN +S L S S D T +W++N G ++V I G V
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
V + W+ + +L + + D IW N S + H + L +N
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290
Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345
Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
++G ++ + + GHT +++ W+P+ ++ S S+D ++IW M
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391
Query: 405 ENI 407
+ +
Sbjct: 392 QEV 394
Score = 53.1 bits (126), Expect = 5e-07
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)
Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
P +GH E + W+ SG LL S SDD T+ +W + +E I D +A H+
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 403
Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
+ + W + + S + D + +WD + H + H V +
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 460
Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
+F+P ++ LA+GS DK V +W+ ++ L +H++ IF+V W+ + + +S +D
Sbjct: 461 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 516
Query: 339 RRLNVWDLSK 348
+ V DL K
Sbjct: 517 GSVCVLDLRK 526
Score = 43.1 bits (100), Expect = 5e-04
Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)
Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
SV + K M D S + ++ H +EV ++NP S+ +LA+GS D T +W+L
Sbjct: 153 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 211
Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
+ +L L H S+KD + + W+ N T+LA+ D +W
Sbjct: 212 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 264
Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
EDG L G H I WN +++ S D IW
Sbjct: 265 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 305
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)
Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
K H+ E+F W+P ++ +LAS D +W+L+ E++ G +L+
Sbjct: 173 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 223
Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
H GGH ++ WN N ++ + S D +IW N+
Sbjct: 224 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 270
Score = 36.2 bits (82), Expect = 0.058
Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)
Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
K DPSG C+ D+ L+ H KE Y + W N N + L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
SAS D TV LWDI G T H V VA+ + L S + D+ +
Sbjct: 428 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479
Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
IW+T+S +LV ++ T + + +N + + A+ S D +V + DLR
Sbjct: 480 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 79.0 bits (193), Expect = 8e-15
Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
H+ + L WN ++LSA D T +WD + G +AK F HSA DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 379
Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
+ + F S + D + + + +P HT EVN + ++P S +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433
Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
T+ +W ++ ++ +H ++H EI+ + WSP ++ +LAS+ D + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
Query: 347 SK 348
+
Sbjct: 493 ER 494
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
LRGH+ E + +WN +S L S S D T +W++N G ++V I G V
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
V + W+ + +L + + D IW N S + H + L +N
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341
Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396
Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
++G ++ + + GHT +++ W+P+ ++ S S+D ++IW M
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442
Query: 405 ENI 407
+ +
Sbjct: 443 QEV 445
Score = 53.1 bits (126), Expect = 5e-07
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)
Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
P +GH E + W+ SG LL S SDD T+ +W + +E I D +A H+
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 454
Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
+ + W + + S + D + +WD + H + H V +
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 511
Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
+F+P ++ LA+GS DK V +W+ ++ L +H++ IF+V W+ + + +S +D
Sbjct: 512 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 567
Query: 339 RRLNVWDLSK 348
+ V DL K
Sbjct: 568 GSVCVLDLRK 577
Score = 43.1 bits (100), Expect = 5e-04
Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)
Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
SV + K M D S + ++ H +EV ++NP S+ +LA+GS D T +W+L
Sbjct: 204 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 262
Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
+ +L L H S+KD + + W+ N T+LA+ D +W
Sbjct: 263 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 315
Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
EDG L G H I WN +++ S D IW
Sbjct: 316 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 356
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)
Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
K H+ E+F W+P ++ +LAS D +W+L+ E++ G +L+
Sbjct: 224 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 274
Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
H GGH ++ WN N ++ + S D +IW N+
Sbjct: 275 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 321
Score = 36.2 bits (82), Expect = 0.058
Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)
Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
K DPSG C+ D+ L+ H KE Y + W N N + L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
SAS D TV LWDI G T H V VA+ + L S + D+ +
Sbjct: 479 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530
Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
IW+T+S +LV ++ T + + +N + + A+ S D +V + DLR
Sbjct: 531 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 79.0 bits (193), Expect = 8e-15
Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
H+ + L WN ++LSA D T +WD + G +AK F HSA DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 379
Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
+ + F S + D + + + +P HT EVN + ++P S +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433
Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
T+ +W ++ ++ +H ++H EI+ + WSP ++ +LAS+ D + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
Query: 347 SK 348
+
Sbjct: 493 ER 494
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
LRGH+ E + +WN +S L S S D T +W++N G ++V I G V
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
V + W+ + +L + + D IW N S + H + L +N
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341
Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396
Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
++G ++ + + GHT +++ W+P+ ++ S S+D ++IW M
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442
Query: 405 ENI 407
+ +
Sbjct: 443 QEV 445
Score = 53.1 bits (126), Expect = 5e-07
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)
Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
P +GH E + W+ SG LL S SDD T+ +W + +E I D +A H+
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 454
Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
+ + W + + S + D + +WD + H + H V +
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 511
Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
+F+P ++ LA+GS DK V +W+ ++ L +H++ IF+V W+ + + +S +D
Sbjct: 512 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 567
Query: 339 RRLNVWDLSK 348
+ V DL K
Sbjct: 568 GSVCVLDLRK 577
Score = 43.1 bits (100), Expect = 5e-04
Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)
Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
SV + K M D S + ++ H +EV ++NP S+ +LA+GS D T +W+L
Sbjct: 204 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 262
Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
+ +L L H S+KD + + W+ N T+LA+ D +W
Sbjct: 263 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 315
Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
EDG L G H I WN +++ S D IW
Sbjct: 316 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 356
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)
Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
K H+ E+F W+P ++ +LAS D +W+L+ E++ G +L+
Sbjct: 224 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 274
Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
H GGH ++ WN N ++ + S D +IW N+
Sbjct: 275 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 321
Score = 36.2 bits (82), Expect = 0.058
Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)
Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
K DPSG C+ D+ L+ H KE Y + W N N + L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
SAS D TV LWDI G T H V VA+ + L S + D+ +
Sbjct: 479 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530
Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
IW+T+S +LV ++ T + + +N + + A+ S D +V + DLR
Sbjct: 531 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 77.8 bits (190), Expect = 2e-14
Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 35/219 (15%)
Query: 187 NLSGH-LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSV 245
N SG ++ S D T LWD +G + + GH VV +A++ + +
Sbjct: 101 NKSGSCFITGSYDRTCKLWDTASGEELNTL-------EGHRNVVYAIAFNNPYGDKIATG 153
Query: 246 ADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 305
+ D+ +W T K H HTAE+ CLSFNP S ++ATGS D T LWD++N
Sbjct: 154 SFDKTCKLWSVE---TGKCYHTFRGHTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNG 209
Query: 306 KLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPEL 365
+ +++T H EI + ++ + I+ S D + VW DA+ G
Sbjct: 210 E-EVYTLRGHSAEIISLSFNTSGDRIITGS-FDHTVVVW------------DADTGRKVN 255
Query: 366 LFIHGGHTAKISDFSWNPNEPW---VICSVSEDNIMQIW 401
+ I GH A+IS S+N W +I + S D ++W
Sbjct: 256 ILI--GHCAEISSASFN----WDCSLILTGSMDKTCKLW 288
Score = 64.3 bits (155), Expect = 2e-10
Identities = 55/208 (26%), Positives = 86/208 (41%), Gaps = 43/208 (20%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG------------------ 213
LRGH E LS+N++ +++ S DHTV +WD + G K
Sbjct: 215 LRGHSAEIISLSFNTS-GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDC 273
Query: 214 ------------KIVDAK-----AIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDT 256
K+ DA A TGH + D + + + + AD +
Sbjct: 274 SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF--- 330
Query: 257 RSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHK 316
S T K ++ H E++ +SFNP +L TGS+DKT +WD + + L E H
Sbjct: 331 -SAATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQC-LQVLEGHT 387
Query: 317 DEIFQVHWSPHNETILASSGTDRRLNVW 344
DEIF ++ + I+ + D +W
Sbjct: 388 DEIFSCAFN-YKGNIVITGSKDNTCRIW 414
Score = 63.5 bits (153), Expect = 3e-10
Identities = 66/233 (28%), Positives = 101/233 (43%), Gaps = 38/233 (16%)
Query: 173 RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT--GHSAVVE 230
RGH E LS+N S + + S D T LWDI G + ++T GHSA +
Sbjct: 174 RGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEE---------VYTLRGHSAEII 223
Query: 231 DVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILAT 290
++++ + + + D +++WD T + +++ H AE++ SFN IL T
Sbjct: 224 SLSFNTSGDRIITG-SFDHTVVVWDA---DTGRKVNILIGHCAEISSASFNWDCSLIL-T 278
Query: 291 GSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASS--GTDRRLNVWDLSK 348
GS DKT LWD N K + T H DEI + + I +S GT R +
Sbjct: 279 GSMDKTCKLWDATNGKC-VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337
Query: 349 IGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
I + + GH +IS S+NP ++ S D +IW
Sbjct: 338 IAKLE-----------------GHEGEISKISFNPQGNHLLTG-SSDKTARIW 372
Score = 30.4 bits (67), Expect = 3.2
Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 13/98 (13%)
Query: 107 FGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGEC 166
F + T K +++ HEGE+++ + PQ H++ T SSD + +G+C
Sbjct: 330 FSAATRKCIAKLE-GHEGEISKISFNPQGNHLL---TGSSDKTARIWDAQ------TGQC 379
Query: 167 NPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLW 204
L GH E + ++N +++ S D+T +W
Sbjct: 380 LQ--VLEGHTDEIFSCAFNYK-GNIVITGSKDNTCRIW 414
>gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo
sapiens]
Length = 731
Score = 72.8 bits (177), Expect = 6e-13
Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 13/167 (7%)
Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
+SW+S L S+ + TV LWD G + ++ H V ++L+ L
Sbjct: 476 ISWSSYHKNLLASSDYEGTVILWDGFTGQRS-------KVYQEHEKRCWSVDFNLMDPKL 528
Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
S +DD K+ +W T + + ++A A V C+ F+P S + LA G AD V +D
Sbjct: 529 LASGSDDAKVKLWSTNLDNSVAS---IEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 584
Query: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 348
LRN K + F+ H+ + + E + AS TD +L +W++ K
Sbjct: 585 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 629
Score = 38.1 bits (87), Expect = 0.015
Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)
Query: 273 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHTFESHKDEIFQVHWSPHNETI 331
++++C+S++ Y + +LA+ + TV LWD + K+ ++ H+ + V ++ + +
Sbjct: 471 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 528
Query: 332 LASSGTDRRLNVW 344
LAS D ++ +W
Sbjct: 529 LASGSDDAKVKLW 541
>gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo
sapiens]
Length = 707
Score = 72.8 bits (177), Expect = 6e-13
Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 13/167 (7%)
Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
+SW+S L S+ + TV LWD G + ++ H V ++L+ L
Sbjct: 452 ISWSSYHKNLLASSDYEGTVILWDGFTGQRS-------KVYQEHEKRCWSVDFNLMDPKL 504
Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
S +DD K+ +W T + + ++A A V C+ F+P S + LA G AD V +D
Sbjct: 505 LASGSDDAKVKLWSTNLDNSVAS---IEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560
Query: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 348
LRN K + F+ H+ + + E + AS TD +L +W++ K
Sbjct: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605
Score = 38.1 bits (87), Expect = 0.015
Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)
Query: 273 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHTFESHKDEIFQVHWSPHNETI 331
++++C+S++ Y + +LA+ + TV LWD + K+ ++ H+ + V ++ + +
Sbjct: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504
Query: 332 LASSGTDRRLNVW 344
LAS D ++ +W
Sbjct: 505 LASGSDDAKVKLW 517
>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
sapiens]
Length = 387
Score = 72.8 bits (177), Expect = 6e-13
Identities = 52/227 (22%), Positives = 96/227 (42%), Gaps = 21/227 (9%)
Query: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251
++S +D+H + LWD+ + + + ++ W H + A+D L
Sbjct: 151 IISLADNH-ILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTL 209
Query: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 311
WDTRS S+ + +AH V L FNP ++ LA+ D V WD RN+ + T
Sbjct: 210 RGWDTRS--MSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKT 267
Query: 312 FESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEE--------QSAEDAEDGPP 363
E H ++ V ++ ++ ++ + +D R+ + ++ I E D ED
Sbjct: 268 LEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRS 327
Query: 364 E----------LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQI 400
E ++ + H + W+ +PW+ S+S D + I
Sbjct: 328 EEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVI 374
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/208 (21%), Positives = 76/208 (36%), Gaps = 27/208 (12%)
Query: 203 LWDINAGPKEGKIVDAKAIFTGHSAVVEDVA-WHLLHESLFGS--VADDQKLMIWDTRSN 259
+W I+A P + ++ T S V+ A W + E GS DD + +
Sbjct: 67 IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121
Query: 260 TTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDE- 318
T HL + + C+ + P + AD + LWDL+ + S E
Sbjct: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181
Query: 319 -----IFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHT 373
WSPH+ ++ D L WD + + E+A H
Sbjct: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA-------------HG 228
Query: 374 AKISDFSWNPNEPWVICSVSEDNIMQIW 401
+ D +NPN+ + + S +D ++ W
Sbjct: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256
Score = 40.8 bits (94), Expect = 0.002
Identities = 39/168 (23%), Positives = 66/168 (39%), Gaps = 37/168 (22%)
Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
L +N N +L S DD V WD + + HS V +V ++ H+ L
Sbjct: 234 LDFNPNKQYYLASCGDDCKVKFWDTR------NVTEPVKTLEEHSHWVWNVRYNHSHDQL 287
Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVD--------AHTAEVNCLSFNPYSEFILATGSA 293
+ + D ++++ + S ++ HLVD H +E S P + ++A
Sbjct: 288 VLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEK--SKEPLQDNVIA---- 341
Query: 294 DKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341
T+E H+D ++ V WS + + AS D RL
Sbjct: 342 -----------------TYEEHEDSVYAVDWSSADPWLFASLSYDGRL 372
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 72.4 bits (176), Expect = 7e-13
Identities = 57/233 (24%), Positives = 101/233 (43%), Gaps = 17/233 (7%)
Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
H +G W+ N + + +D V ++ + + +F+GH+A V V W
Sbjct: 496 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQ-----PLKVFSGHTAKVFHVKW 550
Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
L E + S +DD + IWD T ++++ HTA V L +N ++L +GS D
Sbjct: 551 SPLREGILCSGSDDGTVRIWDY---TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWD 607
Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQS 354
T+ +WD R + T H +++ + P +AS D + +W L+ +
Sbjct: 608 YTIKVWDTRE-GTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQ 666
Query: 355 AEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC-SVSEDNIMQIWQMAEN 406
D E + G+T D++ P P ++C VS D +I ++ N
Sbjct: 667 INILADRSWEEII---GNT----DYAIEPGTPPLLCGKVSRDIRQEIEKLTAN 712
Score = 66.2 bits (160), Expect = 5e-11
Identities = 66/299 (22%), Positives = 115/299 (38%), Gaps = 42/299 (14%)
Query: 120 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 179
+ H + ++ P +P+++AT + + V+D A G EG
Sbjct: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGN------------EG 413
Query: 180 --YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAV-VEDVAWHL 236
Y LSW + + + +W++ ++GKI+ F H + +AW
Sbjct: 414 VIYSLSWAPGGLNCIAGGTSRNGAFIWNV----QKGKIIQR---FNEHGTNGIFCIAWSH 466
Query: 237 LHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKT 296
+ + D +I K H A V ++ ++ ++ATG D
Sbjct: 467 KDSKRIATCSSDGFCIIRTIDGKVLHKYKH-----PAAVFGCDWSQNNKDMIATGCEDTN 521
Query: 297 VALWDLRNLKLK-LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 355
V ++ + + L F H ++F V WSP E IL S D + +WD +
Sbjct: 522 VRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYT-------- 573
Query: 356 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESD 414
+DA + I GHTA + WN P+++ S S D +++W E D D
Sbjct: 574 QDA------CINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD 626
Score = 60.8 bits (146), Expect = 2e-09
Identities = 54/252 (21%), Positives = 105/252 (41%), Gaps = 32/252 (12%)
Query: 170 LRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT--GHSA 227
LR GH + + + + L +AS D T+ +WDIN A++T G+
Sbjct: 363 LRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINT---------LTAVYTSPGNEG 413
Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
V+ ++W + IW+ + + + + T + C++++
Sbjct: 414 VIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFN--EHGTNGIFCIAWSHKDSKR 471
Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 347
+AT S+D +R + K+ H +F WS +N+ ++A+ D + V+ ++
Sbjct: 472 IATCSSD---GFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVA 528
Query: 348 KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE-- 405
++ L + GHTAK+ W+P ++CS S+D ++IW +
Sbjct: 529 TSSDQP------------LKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDA 576
Query: 406 --NIYNDEESDV 415
NI N + V
Sbjct: 577 CINILNGHTAPV 588
Score = 43.5 bits (101), Expect = 4e-04
Identities = 34/140 (24%), Positives = 55/140 (39%), Gaps = 17/140 (12%)
Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
H +V ++ P I+ + + V ++DYT+ L GH G
Sbjct: 541 HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINI----------LNGHTAPVRG 590
Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
L WN+ + L+S S D+T+ +WD +EG VD H A V + H
Sbjct: 591 LMWNTEIPYLLISGSWDYTIKVWD----TREGTCVDT---VYDHGADVYGLTCHPSRPFT 643
Query: 242 FGSVADDQKLMIWDTRSNTT 261
S + D + +W + T
Sbjct: 644 MASCSRDSTVRLWSLTALVT 663
Score = 39.7 bits (91), Expect = 0.005
Identities = 29/105 (27%), Positives = 46/105 (43%), Gaps = 15/105 (14%)
Query: 301 DLRNLKLKLHTFES-HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 359
D R + KLH S HK I + W PHN + AS TD + +W++++ + + D+
Sbjct: 43 DHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-QKVIAKLDST 101
Query: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
G P + SW N V+ VS + IW ++
Sbjct: 102 KGIP-------------ASLSWCWNAEDVVAFVSHRGPLFIWTIS 133
Score = 35.0 bits (79), Expect = 0.13
Identities = 25/122 (20%), Positives = 53/122 (43%), Gaps = 17/122 (13%)
Query: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326
++ H + +S+ P++ + A+GS D V +W++ K+ + +S K + W
Sbjct: 54 IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKV-IAKLDSTKGIPASLSWCW 112
Query: 327 HNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISD---FSWNP 383
+ E ++A L +W +S GP + +H + +SD F W+
Sbjct: 113 NAEDVVAFVSHRGPLFIWTIS-------------GPDSGVIVHKDAHSFLSDICMFRWHT 159
Query: 384 NE 385
++
Sbjct: 160 HQ 161
Score = 32.7 bits (73), Expect = 0.64
Identities = 14/34 (41%), Positives = 20/34 (58%)
Query: 372 HTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
H I+ SW P+ P + S S DN++ IW +AE
Sbjct: 58 HKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE 91
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 72.4 bits (176), Expect = 7e-13
Identities = 57/233 (24%), Positives = 101/233 (43%), Gaps = 17/233 (7%)
Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
H +G W+ N + + +D V ++ + + +F+GH+A V V W
Sbjct: 520 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQ-----PLKVFSGHTAKVFHVKW 574
Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
L E + S +DD + IWD T ++++ HTA V L +N ++L +GS D
Sbjct: 575 SPLREGILCSGSDDGTVRIWDY---TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWD 631
Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQS 354
T+ +WD R + T H +++ + P +AS D + +W L+ +
Sbjct: 632 YTIKVWDTRE-GTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQ 690
Query: 355 AEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC-SVSEDNIMQIWQMAEN 406
D E + G+T D++ P P ++C VS D +I ++ N
Sbjct: 691 INILADRSWEEII---GNT----DYAIEPGTPPLLCGKVSRDIRQEIEKLTAN 736
Score = 66.2 bits (160), Expect = 5e-11
Identities = 66/299 (22%), Positives = 115/299 (38%), Gaps = 42/299 (14%)
Query: 120 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 179
+ H + ++ P +P+++AT + + V+D A G EG
Sbjct: 390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGN------------EG 437
Query: 180 --YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAV-VEDVAWHL 236
Y LSW + + + +W++ ++GKI+ F H + +AW
Sbjct: 438 VIYSLSWAPGGLNCIAGGTSRNGAFIWNV----QKGKIIQR---FNEHGTNGIFCIAWSH 490
Query: 237 LHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKT 296
+ + D +I K H A V ++ ++ ++ATG D
Sbjct: 491 KDSKRIATCSSDGFCIIRTIDGKVLHKYKH-----PAAVFGCDWSQNNKDMIATGCEDTN 545
Query: 297 VALWDLRNLKLK-LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 355
V ++ + + L F H ++F V WSP E IL S D + +WD +
Sbjct: 546 VRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYT-------- 597
Query: 356 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESD 414
+DA + I GHTA + WN P+++ S S D +++W E D D
Sbjct: 598 QDA------CINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD 650
Score = 60.8 bits (146), Expect = 2e-09
Identities = 54/252 (21%), Positives = 105/252 (41%), Gaps = 32/252 (12%)
Query: 170 LRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT--GHSA 227
LR GH + + + + L +AS D T+ +WDIN A++T G+
Sbjct: 387 LRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINT---------LTAVYTSPGNEG 437
Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
V+ ++W + IW+ + + + + T + C++++
Sbjct: 438 VIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFN--EHGTNGIFCIAWSHKDSKR 495
Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 347
+AT S+D +R + K+ H +F WS +N+ ++A+ D + V+ ++
Sbjct: 496 IATCSSD---GFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVA 552
Query: 348 KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE-- 405
++ L + GHTAK+ W+P ++CS S+D ++IW +
Sbjct: 553 TSSDQP------------LKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDA 600
Query: 406 --NIYNDEESDV 415
NI N + V
Sbjct: 601 CINILNGHTAPV 612
Score = 43.5 bits (101), Expect = 4e-04
Identities = 34/140 (24%), Positives = 55/140 (39%), Gaps = 17/140 (12%)
Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
H +V ++ P I+ + + V ++DYT+ L GH G
Sbjct: 565 HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINI----------LNGHTAPVRG 614
Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
L WN+ + L+S S D+T+ +WD +EG VD H A V + H
Sbjct: 615 LMWNTEIPYLLISGSWDYTIKVWD----TREGTCVDT---VYDHGADVYGLTCHPSRPFT 667
Query: 242 FGSVADDQKLMIWDTRSNTT 261
S + D + +W + T
Sbjct: 668 MASCSRDSTVRLWSLTALVT 687
Score = 39.7 bits (91), Expect = 0.005
Identities = 29/105 (27%), Positives = 46/105 (43%), Gaps = 15/105 (14%)
Query: 301 DLRNLKLKLHTFES-HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 359
D R + KLH S HK I + W PHN + AS TD + +W++++ + + D+
Sbjct: 67 DHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-QKVIAKLDST 125
Query: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
G P + SW N V+ VS + IW ++
Sbjct: 126 KGIP-------------ASLSWCWNAEDVVAFVSHRGPLFIWTIS 157
Score = 35.0 bits (79), Expect = 0.13
Identities = 25/122 (20%), Positives = 53/122 (43%), Gaps = 17/122 (13%)
Query: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326
++ H + +S+ P++ + A+GS D V +W++ K+ + +S K + W
Sbjct: 78 IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKV-IAKLDSTKGIPASLSWCW 136
Query: 327 HNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISD---FSWNP 383
+ E ++A L +W +S GP + +H + +SD F W+
Sbjct: 137 NAEDVVAFVSHRGPLFIWTIS-------------GPDSGVIVHKDAHSFLSDICMFRWHT 183
Query: 384 NE 385
++
Sbjct: 184 HQ 185
Score = 32.7 bits (73), Expect = 0.64
Identities = 14/34 (41%), Positives = 20/34 (58%)
Query: 372 HTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
H I+ SW P+ P + S S DN++ IW +AE
Sbjct: 82 HKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE 115
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 72.4 bits (176), Expect = 7e-13
Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 63/283 (22%)
Query: 174 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVA 233
GHQ+ ++W S +L SAS D T C+W N E GH V+ VA
Sbjct: 59 GHQRTVRKVAW-SPCGNYLASASFDATTCIWKKNQDDFE-----CVTTLEGHENEVKSVA 112
Query: 234 WHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 293
W +L + + D+ + +W+ + ++++HT +V + ++P S+ +LA+ S
Sbjct: 113 W-APSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP-SQELLASASY 170
Query: 294 DKTVALW-DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEE 352
D TV L+ + + + T E H+ ++ + + P + LAS DR + +W G E
Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNE 229
Query: 353 QSA------------------------------------------------EDAEDGPPE 364
Q ED P +
Sbjct: 230 QGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQ 289
Query: 365 LLF-----IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 402
F +H H+ ++ +WNP EP ++ S S+D + W+
Sbjct: 290 PTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332
Score = 60.1 bits (144), Expect = 4e-09
Identities = 41/186 (22%), Positives = 78/186 (41%), Gaps = 34/186 (18%)
Query: 240 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 299
+L S D+++ IW T ++ S L + H V ++++P + LA+ S D T +
Sbjct: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY-LASASFDATTCI 87
Query: 300 WDLRNLKLK-LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDA 358
W + + T E H++E+ V W+P +LA+ D+ + VW++
Sbjct: 88 WKKNQDDFECVTTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVWEVD----------- 135
Query: 359 EDGPPELLFIHGGHTAKISDFSWNPNEP--------------------WVICSVSEDNIM 398
E+ E + + HT + W+P++ WV C+ E +
Sbjct: 136 EEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHES 195
Query: 399 QIWQMA 404
+W +A
Sbjct: 196 TVWSLA 201
Score = 58.2 bits (139), Expect = 1e-08
Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 15/143 (10%)
Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLW-DINAGPKEGKIVDA-----KAIFT-- 223
L GH+ + L+++ + L S SDD TV +W G ++G K I T
Sbjct: 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 224 -GHSAVVEDVAWHLLHESLFGSVADD-----QKLMIWDTRSNTTSKPSHLVDAHTAEVNC 277
HS + D+AW L +L + DD Q+ D + T S +HL AH+ +VNC
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308
Query: 278 LSFNPYSEFILATGSADKTVALW 300
+++NP +LA+ S D VA W
Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331
Score = 30.4 bits (67), Expect = 3.2
Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 17/96 (17%)
Query: 324 WSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNP 383
W+P T+LAS G DRR+ +W G E + + + GH + +W+P
Sbjct: 24 WNPAG-TLLASCGGDRRIRIW-----GTEGDSWICKS------VLSEGHQRTVRKVAWSP 71
Query: 384 NEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSE 419
+ + S S D IW+ + D+ VTT E
Sbjct: 72 CGNY-LASASFDATTCIWKKNQ----DDFECVTTLE 102
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 72.0 bits (175), Expect = 1e-12
Identities = 76/291 (26%), Positives = 131/291 (45%), Gaps = 36/291 (12%)
Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
H G V + PQ P +I + + ++++ T+ D + P LRGH
Sbjct: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVSD 68
Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
+ +S+ LS S D T+ LWD+ G + F GH+ V VA+ + +
Sbjct: 69 VVISSD-GQFALSGSWDGTLRLWDLTTGTTTRR-------FVGHTKDVLSVAFSSDNRQI 120
Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEF-ILATGSADKTVALW 300
S + D+ + +W+T K + ++H+ V+C+ F+P S I+ + DK V +W
Sbjct: 121 V-SGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177
Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360
+L N KLK + H + V SP + ++ AS G D + +WDL++
Sbjct: 178 NLANCKLKTNHI-GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNE------------ 223
Query: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 411
L + GG I+ ++PN W +C+ + +I +IW + I DE
Sbjct: 224 -GKHLYTLDGGDI--INALCFSPNRYW-LCAATGPSI-KIWDLEGKIIVDE 269
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 72.0 bits (175), Expect = 1e-12
Identities = 49/153 (32%), Positives = 79/153 (51%), Gaps = 13/153 (8%)
Query: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251
L+S SDD T+ LW P E K + TGH A++ V + + S + D+ +
Sbjct: 52 LVSGSDDFTLFLWS----PAEDKKPLTR--MTGHQALINQVLFSP-DSRIVASASFDKSI 104
Query: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 311
+WD R T K + H A V ++++ S +L +GS+D T+ +WD++ KL +
Sbjct: 105 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 159
Query: 312 FESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
H DE++ V WSP + + AS G D+ L +W
Sbjct: 160 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 191
Score = 40.4 bits (93), Expect = 0.003
Identities = 31/116 (26%), Positives = 54/116 (46%), Gaps = 16/116 (13%)
Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 347
L +GS D T+ LW K L H+ I QV +SP + I+AS+ D+ + +WD
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-G 109
Query: 348 KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
+ G + L GH A + +W+ + ++ S S D+ +++W +
Sbjct: 110 RTG-------------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDV 151
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 72.0 bits (175), Expect = 1e-12
Identities = 49/153 (32%), Positives = 79/153 (51%), Gaps = 13/153 (8%)
Query: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251
L+S SDD T+ LW P E K + TGH A++ V + + S + D+ +
Sbjct: 344 LVSGSDDFTLFLWS----PAEDKKPLTR--MTGHQALINQVLFSP-DSRIVASASFDKSI 396
Query: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 311
+WD R T K + H A V ++++ S +L +GS+D T+ +WD++ KL +
Sbjct: 397 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 451
Query: 312 FESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
H DE++ V WSP + + AS G D+ L +W
Sbjct: 452 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 483
Score = 53.9 bits (128), Expect = 3e-07
Identities = 66/288 (22%), Positives = 107/288 (37%), Gaps = 73/288 (25%)
Query: 161 DPSGECNPDLRLRGHQKEGYGLSWNSNLSG----HLLSASDDHTVCLWDINAGPKEGKIV 216
DPS L GH K GLSW + ++ S+S D +V +WD AG E
Sbjct: 184 DPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCE---- 239
Query: 217 DAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVN 276
I TGH+ V + W + L S + D+ + +W + + H VN
Sbjct: 240 ---RILTGHTQSVTCLRWG--GDGLLYSASQDRTIKVWRAHDGVLCR---TLQGHGHWVN 291
Query: 277 CL-----------SFNPYSEFI------------------------------LATGSADK 295
+ +F P + L +GS D
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDF 351
Query: 296 TVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 355
T+ LW K L H+ I QV +SP + I+AS+ D+ + +WD + G
Sbjct: 352 TLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-GRTG----- 404
Query: 356 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
+ L GH A + +W+ + ++ S S D+ +++W +
Sbjct: 405 --------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDV 443
Score = 52.4 bits (124), Expect = 8e-07
Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 24/176 (13%)
Query: 257 RSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHK 316
R ++ + ++ H+ V ++F+P ++ LA+GS D TV WDL + + T + H+
Sbjct: 99 RVRAVTRCTSSLEGHSEAVISVAFSPTGKY-LASGSGDTTVRFWDL-STETPHFTCKGHR 156
Query: 317 DEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKI 376
+ + WSP LAS + ++ +WD S G++ A GH+ I
Sbjct: 157 HWVLSISWSPDGRK-LASGCKNGQILLWDPS-TGKQVGRTLA------------GHSKWI 202
Query: 377 SDFSWNP----NEPWVICSVSEDNIMQIWQ----MAENIYNDEESDVTTSELEGQG 424
+ SW P E + S S+D ++IW E I VT G G
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG 258
>gi|109627650 coronin 6 [Homo sapiens]
Length = 472
Score = 70.9 bits (172), Expect = 2e-12
Identities = 48/188 (25%), Positives = 89/188 (47%), Gaps = 15/188 (7%)
Query: 211 KEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWD----TRSNTTSKPSH 266
K G++ + TGH+A V D+ W ++++ S +DD +M+W T ++P
Sbjct: 66 KTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPII 125
Query: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326
++ H+ V LS++P + +L + D + +W++ ++ L + H D I V W+
Sbjct: 126 TLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWN- 184
Query: 327 HNETILASSGTDRRLNVWDLSK--IGEEQSAEDAEDGPPELLFIHGGH--TAKISDFS-- 380
N ++LA++ D+ L + D K + E+ A P +F GH T + S
Sbjct: 185 SNGSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQGHIFTTGFTRMSQR 244
Query: 381 ----WNPN 384
W+PN
Sbjct: 245 ELGLWDPN 252
Score = 52.4 bits (124), Expect = 8e-07
Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 10/198 (5%)
Query: 174 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVA 233
GH + W + + SASDD T+ +W I I + GHS V ++
Sbjct: 79 GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILS 138
Query: 234 WHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 293
WH ++ S D ++IW+ T L D H ++ + +N +LAT
Sbjct: 139 WHPTARNVLLSAGGDNVIIIWNV--GTGEVLLSLDDMHPDVIHSVCWNSNGS-LLATTCK 195
Query: 294 DKTVALWDLRNLKLKLHTFESHKD-----EIFQVHWSPHNETILASSGTDRRLNVWDLSK 348
DKT+ + D R ++ F +H+ +F H T + + R L +WD +
Sbjct: 196 DKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFT--RQGHIFTTGFTRMSQRELGLWDPNN 253
Query: 349 IGEEQSAEDAEDGPPELL 366
E + ++ + LL
Sbjct: 254 FEEPVALQEMDTSNGVLL 271
Score = 49.3 bits (116), Expect = 7e-06
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 18/152 (11%)
Query: 111 TGKIECEIKI--NHEGEVNRARYMPQNPHIIATKTPSSDVLVF---DYTKHPAKPDPSGE 165
TG+++ + H V + P N ++IA+ + + ++V+ DYT P +
Sbjct: 67 TGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYT--PMR----NI 120
Query: 166 CNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGH 225
P + L GH K LSW+ LLSA D+ + +W++ G + D H
Sbjct: 121 TEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDM------H 174
Query: 226 SAVVEDVAWHLLHESLFGSVADDQKLMIWDTR 257
V+ V W+ + SL + D+ L I D R
Sbjct: 175 PDVIHSVCWN-SNGSLLATTCKDKTLRIIDPR 205
Score = 49.3 bits (116), Expect = 7e-06
Identities = 22/89 (24%), Positives = 41/89 (46%), Gaps = 7/89 (7%)
Query: 315 HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTA 374
H + + W PHN+ ++AS+ D + VW + ++ E + GH+
Sbjct: 80 HTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNIT-------EPIITLEGHSK 132
Query: 375 KISDFSWNPNEPWVICSVSEDNIMQIWQM 403
++ SW+P V+ S DN++ IW +
Sbjct: 133 RVGILSWHPTARNVLLSAGGDNVIIIWNV 161
Score = 37.4 bits (85), Expect = 0.026
Identities = 14/35 (40%), Positives = 21/35 (60%)
Query: 371 GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
GHTA + D W P+ VI S S+D + +WQ+ +
Sbjct: 79 GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPD 113
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 69.7 bits (169), Expect = 5e-12
Identities = 72/312 (23%), Positives = 127/312 (40%), Gaps = 61/312 (19%)
Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
HEGEV ++ P + + D L+ + + G+C+ L+GH
Sbjct: 65 HEGEVYCCKFHPNGSTLASA---GFDRLILLWNVY-------GDCDNYATLKGHSGAVME 114
Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
L +N++ S L SAS D TV +WD G + ++ GH++ V L
Sbjct: 115 LHYNTDGS-MLFSASTDKTVAVWDSETGERVKRL-------KGHTSFVNSCYPARRGPQL 166
Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
+ +DD + +WD R + +T +V ++FN S+ I++ G D + +WD
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQ----NTYQVLAVTFNDTSDQIIS-GGIDNDIKVWD 221
Query: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDL--------------- 346
LR KL +T H D + + S +L S+ D + VWD+
Sbjct: 222 LRQNKLT-YTMRGHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRPFAPKERCVKIFQG 279
Query: 347 --------------SKIGEEQSAEDAE-------DGPPELLFIHGGHTAKISDFSWNPNE 385
S G + +A A+ +L+ GH I++ +++P+E
Sbjct: 280 NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339
Query: 386 PWVICSVSEDNI 397
P +I + S+ +
Sbjct: 340 PIIISASSDKRL 351
Score = 69.3 bits (168), Expect = 6e-12
Identities = 64/238 (26%), Positives = 106/238 (44%), Gaps = 33/238 (13%)
Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSA 227
P + L GH+ E Y ++ N S L SA D + LW++ D A GHS
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGD------CDNYATLKGHSG 110
Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
V ++ ++ LF S + D+ + +WD+ + K + HT+ VN +
Sbjct: 111 AVMELHYNTDGSMLF-SASTDKTVAVWDSETGERVKR---LKGHTSFVNSCYPARRGPQL 166
Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETI--LASSGTDRRLNVWD 345
+ TGS D TV LWD+R K + TF++ +QV N+T + S G D + VWD
Sbjct: 167 VCTGSDDGTVKLWDIRK-KAAIQTFQN----TYQVLAVTFNDTSDQIISGGIDNDIKVWD 221
Query: 346 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
L + +L + GH ++ S + +E + S + DN +++W +
Sbjct: 222 LRQ--------------NKLTYTMRGHADSVTGLSLS-SEGSYLLSNAMDNTVRVWDV 264
Score = 53.9 bits (128), Expect = 3e-07
Identities = 35/147 (23%), Positives = 68/147 (46%), Gaps = 16/147 (10%)
Query: 257 RSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHK 316
R ++ P L+ H EV C F+P LA+ D+ + LW++ T + H
Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGS-TLASAGFDRLILLWNVYGDCDNYATLKGHS 109
Query: 317 DEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKI 376
+ ++H++ + ++L S+ TD+ + VWD S+ GE GHT+ +
Sbjct: 110 GAVMELHYNT-DGSMLFSASTDKTVAVWD-SETGERVKRLK-------------GHTSFV 154
Query: 377 SDFSWNPNEPWVICSVSEDNIMQIWQM 403
+ P ++C+ S+D +++W +
Sbjct: 155 NSCYPARRGPQLVCTGSDDGTVKLWDI 181
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 69.3 bits (168), Expect = 6e-12
Identities = 64/247 (25%), Positives = 106/247 (42%), Gaps = 32/247 (12%)
Query: 167 NPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTG 224
N + LRGH+ E + +WN +S L S S D T +W+++ G ++V I G
Sbjct: 160 NKAVVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218
Query: 225 HSAV-----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLS 279
V V + W+ +L + + D IW N S + H + L
Sbjct: 219 GQDVPSNKDVTSLDWN-SEGTLLATGSYDGFARIWTKDGNLAS----TLGQHKGPIFALK 273
Query: 280 FNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDR 339
+N FIL+ G DKT +WD + K F H V W +N AS TD
Sbjct: 274 WNKKGNFILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDWQSNN--TFASCSTDM 329
Query: 340 RLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 399
++V K+G+++ + + GHT +++ W+P ++ S S+D ++
Sbjct: 330 CIHV---CKLGQDRPIKTFQ-----------GHTNEVNAIKWDPTGN-LLASCSDDMTLK 374
Query: 400 IWQMAEN 406
IW M ++
Sbjct: 375 IWSMKQD 381
Score = 65.5 bits (158), Expect = 9e-11
Identities = 55/219 (25%), Positives = 87/219 (39%), Gaps = 61/219 (27%)
Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
H+ + L WN +LSA D T +WD + G +AK F HSA DV W
Sbjct: 265 HKGPIFALKWNKK-GNFILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 316
Query: 235 H------------LLHE----------------------------SLFGSVADDQKLMIW 254
+H +L S +DD L IW
Sbjct: 317 QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
Query: 255 DTRSNTTSKPSHLVDAHTAEVNCLSF--------NPYSEFILATGSADKTVALWDLRNLK 306
+ + H + AH E+ + + NP + +LA+ S D TV LWD+ +
Sbjct: 377 SMKQDNCV---HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV-DRG 432
Query: 307 LKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 345
+ +HT H++ ++ V +SP LAS D+ +++W+
Sbjct: 433 ICIHTLTKHQEPVYSVAFSPDGR-YLASGSFDKCVHIWN 470
Score = 36.6 bits (83), Expect = 0.044
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)
Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
K H+ E+F W+P ++ +LAS D +W+LS E++ G +L+
Sbjct: 161 KAVVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLS--------ENSTSGSTQLVL 211
Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
H GG ++ WN +E ++ + S D +IW N+
Sbjct: 212 RHCIREGGQDVPSNKDVTSLDWN-SEGTLLATGSYDGFARIWTKDGNL 258
Score = 34.7 bits (78), Expect = 0.17
Identities = 47/187 (25%), Positives = 70/187 (37%), Gaps = 69/187 (36%)
Query: 172 LRGHQKEGYGLSW--------NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT 223
L+ H KE Y + W N N + L SAS D TV LWD++ G
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRG-------------- 432
Query: 224 GHSAVVEDVAWHLL--HESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFN 281
+ H L H+ SVA F+
Sbjct: 433 --------ICIHTLTKHQEPVYSVA---------------------------------FS 451
Query: 282 PYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341
P + LA+GS DK V +W+ + L +H++ IF+V W+ + + +S +D +
Sbjct: 452 PDGRY-LASGSFDKCVHIWNTQTGAL-VHSYRG-TGGIFEVCWNAAGDKV-GASASDGSV 507
Query: 342 NVWDLSK 348
V DL K
Sbjct: 508 CVLDLRK 514
Score = 31.2 bits (69), Expect = 1.9
Identities = 14/45 (31%), Positives = 25/45 (55%), Gaps = 1/45 (2%)
Query: 362 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 406
PP + GH +++ +WNP ++ S S D+ +IW ++EN
Sbjct: 158 PPNKAVVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLSEN 201
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 68.2 bits (165), Expect = 1e-11
Identities = 60/225 (26%), Positives = 104/225 (46%), Gaps = 26/225 (11%)
Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLR-LRGHQKEGY 180
H G V R+ P H+ A+ + V ++D + +C LR L+GHQ+
Sbjct: 62 HTGPVKFCRFSPDG-HLFASASCDCTVRLWDVAR--------AKC---LRVLKGHQRSVE 109
Query: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
+S++ + S L S D V LWD+ +G + GH ++ +
Sbjct: 110 TVSFSPD-SRQLASGGWDKRVMLWDVQSG-------QMLRLLVGHRDSIQSSDFSPTVNC 161
Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
L + + D + IWD R T + ++ H+A ++CL ++ + +LA+GS DKT+ +W
Sbjct: 162 L-ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS--ASGLLASGSWDKTIHIW 218
Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 345
L + + H + + +SP +E LAS+G R + VWD
Sbjct: 219 KPTTSSLLIQ-LKGHVTWVKSIAFSP-DELWLASAGYSRMVKVWD 261
Score = 67.8 bits (164), Expect = 2e-11
Identities = 75/283 (26%), Positives = 117/283 (41%), Gaps = 45/283 (15%)
Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
H GEVN + + P ++ T S D V+ + SG+ RL GH G
Sbjct: 20 HGGEVNSSAFSPDGQMLL---TGSEDGCVYGWETR------SGQLL--WRLGGHT--GPV 66
Query: 182 LSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
+ GHL SAS D TV LWD+ + GH VE V++
Sbjct: 67 KFCRFSPDGHLFASASCDCTVRLWDVARAK-------CLRVLKGHQRSVETVSFSPDSRQ 119
Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
L S D+++M+WD +S + L+ H + F+P LATGS D TV +W
Sbjct: 120 L-ASGGWDKRVMLWDVQSGQMLR---LLVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIW 174
Query: 301 DLRNL--KLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDA 358
DLR + + E H I + +S +LAS D+ +++W
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIW-------------- 218
Query: 359 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
+ LL GH + +++P+E W + S ++++W
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELW-LASAGYSRMVKVW 260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,155,573
Number of Sequences: 37866
Number of extensions: 843606
Number of successful extensions: 3075
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 182
Number of HSP's that attempted gapping in prelim test: 1591
Number of HSP's gapped (non-prelim): 964
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.