Guide to the Human Genome
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Search of human proteins with 4506439

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
         (425 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]            892   0.0  
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...   805   0.0  
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...   800   0.0  
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...   743   0.0  
gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens]          145   9e-35
gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo sap...   145   9e-35
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]     123   4e-28
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     96   8e-20
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              92   1e-18
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     87   2e-17
gi|217330644 WD repeat domain 12 protein [Homo sapiens]                81   2e-15
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               80   5e-15
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          79   8e-15
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          79   8e-15
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          79   8e-15
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            79   8e-15
gi|32189425 WD repeat domain 69 [Homo sapiens]                         78   2e-14
gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo s...    73   6e-13
gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo...    73   6e-13
gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s...    73   6e-13
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]               72   7e-13
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]               72   7e-13
gi|4757988 WD repeat domain 39 [Homo sapiens]                          72   7e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    72   1e-12
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            72   1e-12
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            72   1e-12
gi|109627650 coronin 6 [Homo sapiens]                                  71   2e-12
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    70   5e-12
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    69   6e-12
gi|113865883 WD repeat domain 38 [Homo sapiens]                        68   1e-11

>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score =  892 bits (2306), Expect = 0.0
 Identities = 425/425 (100%), Positives = 425/425 (100%)

Query: 1   MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY 60
           MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY
Sbjct: 1   MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY 60

Query: 61  ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI 120
           ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI
Sbjct: 61  ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI 120

Query: 121 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 180
           NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY
Sbjct: 121 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 180

Query: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
           GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES
Sbjct: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240

Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
           LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW
Sbjct: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300

Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360
           DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED
Sbjct: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360

Query: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL 420
           GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL
Sbjct: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL 420

Query: 421 EGQGS 425
           EGQGS
Sbjct: 421 EGQGS 425


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score =  805 bits (2078), Expect = 0.0
 Identities = 380/425 (89%), Positives = 403/425 (94%), Gaps = 1/425 (0%)

Query: 1   MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY 60
           MA KE F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VT+PEGKD+
Sbjct: 1   MADKEAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDF 60

Query: 61  ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI 120
           ++H LVLGTHTSDEQNHLV+A V +PNDDAQFDASH DS+KGEFGGFGSV+GKIE EIKI
Sbjct: 61  SIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKI 120

Query: 121 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 180
           NHEGEVNRARYMPQNP IIATKTPSSDVLVFDYTKHP+KPDPSGECNPDLRLRGHQKEGY
Sbjct: 121 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 180

Query: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
           GLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK+VDAK IFTGH+AVVEDV+WHLLHES
Sbjct: 181 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 240

Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
           LFGSVADDQKLMIWDTRSN TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVALW
Sbjct: 241 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300

Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360
           DLRNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRLNVWDLSKIGEEQS EDAED
Sbjct: 301 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 360

Query: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL 420
           GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ+WQMAENIYNDE+ + +  + 
Sbjct: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV-DP 419

Query: 421 EGQGS 425
           EGQGS
Sbjct: 420 EGQGS 424


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score =  800 bits (2066), Expect = 0.0
 Identities = 380/426 (89%), Positives = 403/426 (94%), Gaps = 2/426 (0%)

Query: 1   MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 59
           MA KE  F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VT+PEGKD
Sbjct: 1   MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60

Query: 60  YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIK 119
           +++H LVLGTHTSDEQNHLV+A V +PNDDAQFDASH DS+KGEFGGFGSV+GKIE EIK
Sbjct: 61  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120

Query: 120 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 179
           INHEGEVNRARYMPQNP IIATKTPSSDVLVFDYTKHP+KPDPSGECNPDLRLRGHQKEG
Sbjct: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180

Query: 180 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 239
           YGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK+VDAK IFTGH+AVVEDV+WHLLHE
Sbjct: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240

Query: 240 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 299
           SLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVAL
Sbjct: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300

Query: 300 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 359
           WDLRNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRLNVWDLSKIGEEQS EDAE
Sbjct: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360

Query: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSE 419
           DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ+WQMAENIYNDE+ + +  +
Sbjct: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV-D 419

Query: 420 LEGQGS 425
            EGQGS
Sbjct: 420 PEGQGS 425


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score =  743 bits (1917), Expect = 0.0
 Identities = 350/391 (89%), Positives = 372/391 (95%), Gaps = 1/391 (0%)

Query: 35  MTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDA 94
           MTHAL+WPSLT QWLP+VT+PEGKD+++H LVLGTHTSDEQNHLV+A V +PNDDAQFDA
Sbjct: 1   MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60

Query: 95  SHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYT 154
           SH DS+KGEFGGFGSV+GKIE EIKINHEGEVNRARYMPQNP IIATKTPSSDVLVFDYT
Sbjct: 61  SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120

Query: 155 KHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGK 214
           KHP+KPDPSGECNPDLRLRGHQKEGYGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK
Sbjct: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180

Query: 215 IVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAE 274
           +VDAK IFTGH+AVVEDV+WHLLHESLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAE
Sbjct: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240

Query: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILAS 334
           VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH+FESHKDEIFQV WSPHNETILAS
Sbjct: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300

Query: 335 SGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 394
           SGTDRRLNVWDLSKIGEEQS EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE
Sbjct: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360

Query: 395 DNIMQIWQMAENIYNDEESDVTTSELEGQGS 425
           DNIMQ+WQMAENIYNDE+ + +  + EGQGS
Sbjct: 361 DNIMQVWQMAENIYNDEDPEGSV-DPEGQGS 390


>gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens]
          Length = 103

 Score =  145 bits (365), Expect = 9e-35
 Identities = 72/107 (67%), Positives = 83/107 (77%), Gaps = 5/107 (4%)

Query: 1   MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 59
           M +KE  F++ VEE VI EEYKIWK NT F YDLVMT AL+WPSLT QWLP+VT+PEGKD
Sbjct: 1   MTNKEAAFDNAVEEHVIKEEYKIWKNNTSFPYDLVMTQALEWPSLTAQWLPDVTRPEGKD 60

Query: 60  YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGG 106
           ++ H LV GTHTS EQNHL    V +P+DDAQ DASH +S KGE GG
Sbjct: 61  FSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDASHYNSKKGECGG 103


>gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo
           sapiens]
          Length = 103

 Score =  145 bits (365), Expect = 9e-35
 Identities = 72/107 (67%), Positives = 83/107 (77%), Gaps = 5/107 (4%)

Query: 1   MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 59
           M +KE  F++ VEE VI EEYKIWK NT F YDLVMT AL+WPSLT QWLP+VT+PEGKD
Sbjct: 1   MTNKEAAFDNAVEEHVIKEEYKIWKNNTSFPYDLVMTQALEWPSLTAQWLPDVTRPEGKD 60

Query: 60  YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGG 106
           ++ H LV GTHTS EQNHL    V +P+DDAQ DASH +S KGE GG
Sbjct: 61  FSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDASHYNSKKGECGG 103


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score =  123 bits (308), Expect = 4e-28
 Identities = 96/356 (26%), Positives = 160/356 (44%), Gaps = 35/356 (9%)

Query: 64  WLVLGTHTSDEQ-NHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIK-IN 121
           +L  GT     Q N L++ R+H  +      +   D ++ E         K + E+  + 
Sbjct: 88  YLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVP 147

Query: 122 HEGEVNRAR--YMPQNPHIIATKTPSSDVLVF------DYTKHPAK-----PDPSGECNP 168
           H G +NR R  ++ + P +    +    V VF         + P        D   +  P
Sbjct: 148 HYGGINRVRVSWLGEEP-VAGVWSEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKP 206

Query: 169 DLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKI--VDAKAIFTGHS 226
                GH  EG+ L W+  ++G LL+      + LW     P +G    VD +  F GH+
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWT----PTDGGSWHVDQRP-FVGHT 261

Query: 227 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDA--HTAEVNCLSFNPYS 284
             VED+ W     ++F S + D  + IWD R+   SK   L  A  H  +VN +S++   
Sbjct: 262 RSVEDLQWSPTENTVFASCSADASIRIWDIRA-APSKACMLTTATAHDGDVNVISWSRRE 320

Query: 285 EFILATGSADKTVALWDLRNLKL--KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLN 342
            F+L+ G  D  + +WDLR  K    + TF+ H   +  V W P +  + A+SG D ++ 
Sbjct: 321 PFLLSGGD-DGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQIT 379

Query: 343 VWDLS-----KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 393
            WDL+     + G+ ++     D P +LLF+H G T ++ +  W+P  P ++ S +
Sbjct: 380 QWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGET-ELKELHWHPQCPGLLVSTA 434



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 25/95 (26%), Positives = 40/95 (42%), Gaps = 10/95 (10%)

Query: 309 LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFI 368
           + +F  H  E F + WSP     L +    + +++W  +  G         D  P +   
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHV-----DQRPFV--- 258

Query: 369 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
             GHT  + D  W+P E  V  S S D  ++IW +
Sbjct: 259 --GHTRSVEDLQWSPTENTVFASCSADASIRIWDI 291


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 95.5 bits (236), Expect = 8e-20
 Identities = 76/251 (30%), Positives = 122/251 (48%), Gaps = 31/251 (12%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
           LRGH    Y   + ++ SG LLS S+D ++  WD+ +            ++ GH+  V D
Sbjct: 338 LRGHCGPVYSTRFLADSSG-LLSCSEDMSIRYWDLGSFTNT-------VLYQGHAYPVWD 389

Query: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 291
           +     +   F S + D+   +W   S   + P  +   H A+V+C+ F+P S + LATG
Sbjct: 390 LDISP-YSLYFASGSHDRTARLW---SFDRTYPLRIYAGHLADVDCVKFHPNSNY-LATG 444

Query: 292 SADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGE 351
           S DKTV LW  +     +  F  H+  +  + +SP N   LAS+G D+RL +WDL+    
Sbjct: 445 STDKTVRLWSAQQGN-SVRLFTGHRGPVLSLAFSP-NGKYLASAGEDQRLKLWDLAS--- 499

Query: 352 EQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 411
                        L     GHT  I+  +++P +  +I S S DN +++W +  N Y   
Sbjct: 500 -----------GTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDI-RNTYCSA 546

Query: 412 ESDVTTSELEG 422
            +D ++SEL G
Sbjct: 547 PADGSSSELVG 557



 Score = 28.9 bits (63), Expect = 9.3
 Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 4/49 (8%)

Query: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVH 323
           +N    +P S+ +LA G  +  + LW LR+ KLK    E H+ ++ ++H
Sbjct: 271 LNTAEISPDSK-LLAAGFDNSCIKLWSLRSKKLK---SEPHQVDVSRIH 315


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 71/271 (26%), Positives = 115/271 (42%), Gaps = 33/271 (12%)

Query: 135 NPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLL- 193
           N H++ T +    + ++D  K            P    + H +E Y + W+      L+ 
Sbjct: 79  NEHVLITCSGDGSLQLWDTAK---------AAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129

Query: 194 SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMI 253
           S S D TV LWD    P  GK +     F GH +++    W       F S + DQ L I
Sbjct: 130 SGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182

Query: 254 WDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFE 313
           WD ++   +    ++ AH AE+    +  Y+E +L TG+ D ++  WDLRN++  +    
Sbjct: 183 WDVKA---AGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELL 239

Query: 314 SHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHT 373
            H   I +V +SP + ++LAS   D  +  W+ SK             P  LL     HT
Sbjct: 240 GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK-------------PDSLLETVEHHT 286

Query: 374 AKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
                  ++   P  +   S D  ++I+  A
Sbjct: 287 EFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 15/127 (11%)

Query: 278 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWS-PHNETILASSG 336
           ++++  +E +L T S D ++ LWD       L  ++ H  E++ V WS    E ++ S  
Sbjct: 73  VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS 132

Query: 337 TDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 396
            D+ + +WD   +G+              L    GH + I    W+P+ P    S S D 
Sbjct: 133 WDQTVKLWD-PTVGKS-------------LCTFRGHESIIYSTIWSPHIPGCFASASGDQ 178

Query: 397 IMQIWQM 403
            ++IW +
Sbjct: 179 TLRIWDV 185


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 73/250 (29%), Positives = 116/250 (46%), Gaps = 36/250 (14%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
           L GH    YG S++ + + +LLS+S+D TV LW +               + GH+  V D
Sbjct: 539 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSLQT-------FTCLVGYKGHNYPVWD 590

Query: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 291
             +   +   F S   D+   +W T      +P  +   H A+VNC  F+P S ++ ATG
Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLWATDHY---QPLRIFAGHLADVNCTRFHPNSNYV-ATG 645

Query: 292 SADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS---K 348
           SAD+TV LWD+ N    +  F  HK  I  + +SP N   LA+  TD R+ +WD+     
Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 703

Query: 349 IGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIY 408
           +GE +                 GHT  +    ++  +  ++ S S DN +++W   +   
Sbjct: 704 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLWDAIKAFE 745

Query: 409 NDEESDVTTS 418
           + E  D TT+
Sbjct: 746 DLETDDFTTA 755


>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
          Length = 423

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 52/174 (29%), Positives = 89/174 (51%), Gaps = 13/174 (7%)

Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSA 227
           P + L GH +    + W+   +  + SAS DHT+ +WD+ +G         K+  TG+  
Sbjct: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298

Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
           V   +++  L + L  S + D+ + +WD R+   S  S  + +HT  V  + ++P  E  
Sbjct: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357

Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341
           L +GS D  V LWD R+ K  L+   +H+D++  V W+  +  +L S G D +L
Sbjct: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 47/254 (18%)

Query: 174 GHQKEGYGLSW--NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
           GH      ++W    +LS  LLSAS D T+ LW+ N    E   V A     GH+  V+ 
Sbjct: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194

Query: 232 VAWHLLHESLFGSVADDQKLMIWDT-----------------------RSNTTSKPSHLV 268
           +A      + F S + D+ L IW T                       +   T  P   +
Sbjct: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253

Query: 269 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQ-VHWSPH 327
             H   V+ + ++   E  + + S D T+ +WD+ +  LK  T   +K  +F  + +SP 
Sbjct: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308

Query: 328 NETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 387
            +  LAS  TDR + +WD             +DG    L +   HT  ++   W+P    
Sbjct: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356

Query: 388 VICSVSEDNIMQIW 401
            + S S DNI+++W
Sbjct: 357 QLISGSLDNIVKLW 370



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 44/170 (25%), Positives = 69/170 (40%), Gaps = 16/170 (9%)

Query: 223 TGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP 282
           +GH   V  V W    E    S + D  + +WD  S +               NC+S++P
Sbjct: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLKSTL----TGNKVFNCISYSP 307

Query: 283 YSEFILATGSADKTVALWDLRNLKLKLHTFE--SHKDEIFQVHWSPHNETILASSGTDRR 340
             +  LA+GS D+ + LWD R     L +    SH   +  V WSP +E  L S   D  
Sbjct: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366

Query: 341 LNVWD-------LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNP 383
           + +WD       L  +   +    + D     L + GG   K+  + ++P
Sbjct: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 33/134 (24%), Positives = 53/134 (39%), Gaps = 16/134 (11%)

Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHN--ETILASSGTDRRLN 342
           E+IL TGS DKT  +W L    +   T   H D +  V W   +    +L S+  D+ + 
Sbjct: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168

Query: 343 VWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 402
           +W+           + E    + L    GH   +   + +       CS S D +++IW 
Sbjct: 169 LWEW----------NVERNKVKALHCCRGHAGSVDSIAVD-GSGTKFCSGSWDKMLKIWS 217

Query: 403 MAENIYNDEESDVT 416
                  DE  + T
Sbjct: 218 TVPTDEEDEMEEST 231


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 65/209 (31%), Positives = 92/209 (44%), Gaps = 26/209 (12%)

Query: 194 SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLF-GSVADDQKLM 252
           + SDD TV +WD     +E        I  GH A V+ V WH     +  GS    Q + 
Sbjct: 219 TCSDDGTVRIWDFLRCHEE-------RILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIK 271

Query: 253 IWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTF 312
            WD ++  +    H   AH   V  +  N    ++L T S D    L+D+RNLK +L  F
Sbjct: 272 FWDPKTGQSLATLH---AHKNTVMEVKLNLNGNWLL-TASRDHLCKLFDIRNLKEELQVF 327

Query: 313 ESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGH 372
             HK E   V W P +E + AS G+D  L  W    +G E+     E G  E+      H
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFW---HVGVEK-----EVGGMEM-----AH 374

Query: 373 TAKISDFSWNPNEPWVICSVSEDNIMQIW 401
              I   +W+P    ++CS S D+  + W
Sbjct: 375 EGMIWSLAWHP-LGHILCSGSNDHTSKFW 402



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 46/234 (19%), Positives = 99/234 (42%), Gaps = 31/234 (13%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
           L+ H      ++W+ N    +L+A     V  W  N        ++   +F  H   + +
Sbjct: 157 LQAHDSPVRAMTWSHN-DMWMLTADHGGYVKYWQSN--------MNNVKMFQAHKEAIRE 207

Query: 232 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 291
            ++    ++ F + +DD  + IWD           ++  H A+V C+ ++P ++ ++ +G
Sbjct: 208 ASFSPT-DNKFATCSDDGTVRIWDF---LRCHEERILRGHGADVKCVDWHP-TKGLVVSG 262

Query: 292 SAD--KTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
           S D  + +  WD +  +  L T  +HK+ + +V  + +   +L +S  D    ++D+  +
Sbjct: 263 SKDSQQPIKFWDPKTGQ-SLATLHAHKNTVMEVKLNLNGNWLLTAS-RDHLCKLFDIRNL 320

Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
            EE             L +  GH  + +  +W+P    +  S   D  +  W +
Sbjct: 321 KEE-------------LQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHV 361



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 8/91 (8%)

Query: 173 RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDV 232
           RGH+KE   ++W+    G   S   D ++  W +    + G +  A      H  ++  +
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMA------HEGMIWSL 381

Query: 233 AWHLLHESLFGSVADDQKLMIWDTRSNTTSK 263
           AWH L   L  S ++D     W TR+    K
Sbjct: 382 AWHPLGHILC-SGSNDHTSKFW-TRNRPGDK 410


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)

Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
           H+   + L WN     ++LSA  D T  +WD + G       +AK  F  HSA   DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 328

Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
              + + F S + D  + +     +   +P      HT EVN + ++P S  +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382

Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
            T+ +W ++  ++ +H  ++H  EI+ + WSP        ++  +LAS+  D  + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441

Query: 347 SK 348
            +
Sbjct: 442 ER 443



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
           LRGH+ E +  +WN  +S  L S S D T  +W++N     G  ++V    I  G   V 
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235

Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
               V  + W+  + +L  + + D    IW    N  S     +  H   +  L +N   
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290

Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345

Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  ++IW M 
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391

Query: 405 ENI 407
           + +
Sbjct: 392 QEV 394



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)

Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
           P    +GH  E   + W+   SG LL S SDD T+ +W +    +E  I D +A    H+
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 403

Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
             +  + W     +        +  S + D  + +WD      +   H +  H   V  +
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 460

Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
           +F+P  ++ LA+GS DK V +W+ ++  L +H++      IF+V W+   + +  +S +D
Sbjct: 461 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 516

Query: 339 RRLNVWDLSK 348
             + V DL K
Sbjct: 517 GSVCVLDLRK 526



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)

Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           SV +  K M  D      S  + ++  H +EV   ++NP S+ +LA+GS D T  +W+L 
Sbjct: 153 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 211

Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
                 + +L L        H   S+KD +  + W+  N T+LA+   D    +W     
Sbjct: 212 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 264

Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
                    EDG   L    G H   I    WN    +++ S   D    IW
Sbjct: 265 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 305



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)

Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
           K      H+ E+F   W+P ++ +LAS   D    +W+L+        E++  G  +L+ 
Sbjct: 173 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 223

Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
            H    GGH       ++   WN N   ++ + S D   +IW    N+
Sbjct: 224 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 270



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)

Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
           K DPSG     C+ D+ L+               H KE Y + W        N N +  L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427

Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
            SAS D TV LWDI  G             T H   V  VA+    + L  S + D+ + 
Sbjct: 428 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479

Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           IW+T+S       +LV ++  T  +  + +N   + + A+ S D +V + DLR
Sbjct: 480 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)

Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
           H+   + L WN     ++LSA  D T  +WD + G       +AK  F  HSA   DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 328

Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
              + + F S + D  + +     +   +P      HT EVN + ++P S  +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382

Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
            T+ +W ++  ++ +H  ++H  EI+ + WSP        ++  +LAS+  D  + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441

Query: 347 SK 348
            +
Sbjct: 442 ER 443



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
           LRGH+ E +  +WN  +S  L S S D T  +W++N     G  ++V    I  G   V 
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235

Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
               V  + W+  + +L  + + D    IW    N  S     +  H   +  L +N   
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290

Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345

Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  ++IW M 
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391

Query: 405 ENI 407
           + +
Sbjct: 392 QEV 394



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)

Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
           P    +GH  E   + W+   SG LL S SDD T+ +W +    +E  I D +A    H+
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 403

Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
             +  + W     +        +  S + D  + +WD      +   H +  H   V  +
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 460

Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
           +F+P  ++ LA+GS DK V +W+ ++  L +H++      IF+V W+   + +  +S +D
Sbjct: 461 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 516

Query: 339 RRLNVWDLSK 348
             + V DL K
Sbjct: 517 GSVCVLDLRK 526



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)

Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           SV +  K M  D      S  + ++  H +EV   ++NP S+ +LA+GS D T  +W+L 
Sbjct: 153 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 211

Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
                 + +L L        H   S+KD +  + W+  N T+LA+   D    +W     
Sbjct: 212 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 264

Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
                    EDG   L    G H   I    WN    +++ S   D    IW
Sbjct: 265 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 305



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)

Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
           K      H+ E+F   W+P ++ +LAS   D    +W+L+        E++  G  +L+ 
Sbjct: 173 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 223

Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
            H    GGH       ++   WN N   ++ + S D   +IW    N+
Sbjct: 224 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 270



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)

Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
           K DPSG     C+ D+ L+               H KE Y + W        N N +  L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427

Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
            SAS D TV LWDI  G             T H   V  VA+    + L  S + D+ + 
Sbjct: 428 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479

Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           IW+T+S       +LV ++  T  +  + +N   + + A+ S D +V + DLR
Sbjct: 480 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)

Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
           H+   + L WN     ++LSA  D T  +WD + G       +AK  F  HSA   DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 379

Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
              + + F S + D  + +     +   +P      HT EVN + ++P S  +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433

Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
            T+ +W ++  ++ +H  ++H  EI+ + WSP        ++  +LAS+  D  + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492

Query: 347 SK 348
            +
Sbjct: 493 ER 494



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
           LRGH+ E +  +WN  +S  L S S D T  +W++N     G  ++V    I  G   V 
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286

Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
               V  + W+  + +L  + + D    IW    N  S     +  H   +  L +N   
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341

Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396

Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  ++IW M 
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442

Query: 405 ENI 407
           + +
Sbjct: 443 QEV 445



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)

Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
           P    +GH  E   + W+   SG LL S SDD T+ +W +    +E  I D +A    H+
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 454

Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
             +  + W     +        +  S + D  + +WD      +   H +  H   V  +
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 511

Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
           +F+P  ++ LA+GS DK V +W+ ++  L +H++      IF+V W+   + +  +S +D
Sbjct: 512 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 567

Query: 339 RRLNVWDLSK 348
             + V DL K
Sbjct: 568 GSVCVLDLRK 577



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)

Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           SV +  K M  D      S  + ++  H +EV   ++NP S+ +LA+GS D T  +W+L 
Sbjct: 204 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 262

Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
                 + +L L        H   S+KD +  + W+  N T+LA+   D    +W     
Sbjct: 263 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 315

Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
                    EDG   L    G H   I    WN    +++ S   D    IW
Sbjct: 316 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 356



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)

Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
           K      H+ E+F   W+P ++ +LAS   D    +W+L+        E++  G  +L+ 
Sbjct: 224 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 274

Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
            H    GGH       ++   WN N   ++ + S D   +IW    N+
Sbjct: 275 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 321



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)

Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
           K DPSG     C+ D+ L+               H KE Y + W        N N +  L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478

Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
            SAS D TV LWDI  G             T H   V  VA+    + L  S + D+ + 
Sbjct: 479 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530

Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           IW+T+S       +LV ++  T  +  + +N   + + A+ S D +V + DLR
Sbjct: 531 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 23/182 (12%)

Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
           H+   + L WN     ++LSA  D T  +WD + G       +AK  F  HSA   DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 379

Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
              + + F S + D  + +     +   +P      HT EVN + ++P S  +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRLGCD---RPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433

Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSP--------HNETILASSGTDRRLNVWDL 346
            T+ +W ++  ++ +H  ++H  EI+ + WSP        ++  +LAS+  D  + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492

Query: 347 SK 348
            +
Sbjct: 493 ER 494



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 32/243 (13%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTGHSAV- 228
           LRGH+ E +  +WN  +S  L S S D T  +W++N     G  ++V    I  G   V 
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286

Query: 229 ----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284
               V  + W+  + +L  + + D    IW    N  S     +  H   +  L +N   
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341

Query: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396

Query: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  ++IW M 
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442

Query: 405 ENI 407
           + +
Sbjct: 443 QEV 445



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 25/190 (13%)

Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 226
           P    +GH  E   + W+   SG LL S SDD T+ +W +    +E  I D +A    H+
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMK---QEVCIHDLQA----HN 454

Query: 227 AVVEDVAWHLLHES--------LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
             +  + W     +        +  S + D  + +WD      +   H +  H   V  +
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSV 511

Query: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
           +F+P  ++ LA+GS DK V +W+ ++  L +H++      IF+V W+   + +  +S +D
Sbjct: 512 AFSPDGKY-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASD 567

Query: 339 RRLNVWDLSK 348
             + V DL K
Sbjct: 568 GSVCVLDLRK 577



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 33/172 (19%)

Query: 244 SVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           SV +  K M  D      S  + ++  H +EV   ++NP S+ +LA+GS D T  +W+L 
Sbjct: 204 SVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN 262

Query: 304 ------NLKLKL--------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 349
                 + +L L        H   S+KD +  + W+  N T+LA+   D    +W     
Sbjct: 263 ENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNT-NGTLLATGSYDGFARIW----- 315

Query: 350 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
                    EDG   L    G H   I    WN    +++ S   D    IW
Sbjct: 316 --------TEDG--NLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTIIW 356



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)

Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
           K      H+ E+F   W+P ++ +LAS   D    +W+L+        E++  G  +L+ 
Sbjct: 224 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLN--------ENSNGGSTQLVL 274

Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
            H    GGH       ++   WN N   ++ + S D   +IW    N+
Sbjct: 275 RHCIREGGHDVPSNKDVTSLDWNTNGT-LLATGSYDGFARIWTEDGNL 321



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 50/173 (28%), Positives = 73/173 (42%), Gaps = 43/173 (24%)

Query: 159 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NSNLSGHL 192
           K DPSG     C+ D+ L+               H KE Y + W        N N +  L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478

Query: 193 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 252
            SAS D TV LWDI  G             T H   V  VA+    + L  S + D+ + 
Sbjct: 479 ASASFDSTVRLWDIERGV-------CTHTLTKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530

Query: 253 IWDTRSNTTSKPSHLVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 303
           IW+T+S       +LV ++  T  +  + +N   + + A+ S D +V + DLR
Sbjct: 531 IWNTQS------GNLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 35/219 (15%)

Query: 187 NLSGH-LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSV 245
           N SG   ++ S D T  LWD  +G +   +        GH  VV  +A++  +     + 
Sbjct: 101 NKSGSCFITGSYDRTCKLWDTASGEELNTL-------EGHRNVVYAIAFNNPYGDKIATG 153

Query: 246 ADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 305
           + D+   +W      T K  H    HTAE+ CLSFNP S  ++ATGS D T  LWD++N 
Sbjct: 154 SFDKTCKLWSVE---TGKCYHTFRGHTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNG 209

Query: 306 KLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPEL 365
           + +++T   H  EI  + ++   + I+  S  D  + VW            DA+ G    
Sbjct: 210 E-EVYTLRGHSAEIISLSFNTSGDRIITGS-FDHTVVVW------------DADTGRKVN 255

Query: 366 LFIHGGHTAKISDFSWNPNEPW---VICSVSEDNIMQIW 401
           + I  GH A+IS  S+N    W   +I + S D   ++W
Sbjct: 256 ILI--GHCAEISSASFN----WDCSLILTGSMDKTCKLW 288



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/208 (26%), Positives = 86/208 (41%), Gaps = 43/208 (20%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG------------------ 213
           LRGH  E   LS+N++    +++ S DHTV +WD + G K                    
Sbjct: 215 LRGHSAEIISLSFNTS-GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDC 273

Query: 214 ------------KIVDAK-----AIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDT 256
                       K+ DA      A  TGH   + D  +    + +  + AD    +    
Sbjct: 274 SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF--- 330

Query: 257 RSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHK 316
            S  T K    ++ H  E++ +SFNP    +L TGS+DKT  +WD +  +  L   E H 
Sbjct: 331 -SAATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQC-LQVLEGHT 387

Query: 317 DEIFQVHWSPHNETILASSGTDRRLNVW 344
           DEIF   ++ +   I+ +   D    +W
Sbjct: 388 DEIFSCAFN-YKGNIVITGSKDNTCRIW 414



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 66/233 (28%), Positives = 101/233 (43%), Gaps = 38/233 (16%)

Query: 173 RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT--GHSAVVE 230
           RGH  E   LS+N   S  + + S D T  LWDI  G +         ++T  GHSA + 
Sbjct: 174 RGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEE---------VYTLRGHSAEII 223

Query: 231 DVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILAT 290
            ++++   + +    + D  +++WD     T +  +++  H AE++  SFN     IL T
Sbjct: 224 SLSFNTSGDRIITG-SFDHTVVVWDA---DTGRKVNILIGHCAEISSASFNWDCSLIL-T 278

Query: 291 GSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASS--GTDRRLNVWDLSK 348
           GS DKT  LWD  N K  + T   H DEI    +    + I  +S  GT R  +      
Sbjct: 279 GSMDKTCKLWDATNGKC-VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337

Query: 349 IGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
           I + +                 GH  +IS  S+NP    ++   S D   +IW
Sbjct: 338 IAKLE-----------------GHEGEISKISFNPQGNHLLTG-SSDKTARIW 372



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 13/98 (13%)

Query: 107 FGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGEC 166
           F + T K   +++  HEGE+++  + PQ  H++   T SSD     +         +G+C
Sbjct: 330 FSAATRKCIAKLE-GHEGEISKISFNPQGNHLL---TGSSDKTARIWDAQ------TGQC 379

Query: 167 NPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLW 204
                L GH  E +  ++N      +++ S D+T  +W
Sbjct: 380 LQ--VLEGHTDEIFSCAFNYK-GNIVITGSKDNTCRIW 414


>gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo
           sapiens]
          Length = 731

 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 13/167 (7%)

Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
           +SW+S     L S+  + TV LWD   G +         ++  H      V ++L+   L
Sbjct: 476 ISWSSYHKNLLASSDYEGTVILWDGFTGQRS-------KVYQEHEKRCWSVDFNLMDPKL 528

Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
             S +DD K+ +W T  + +      ++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 529 LASGSDDAKVKLWSTNLDNSVAS---IEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 584

Query: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 348
           LRN K  +  F+ H+  +    +    E + AS  TD +L +W++ K
Sbjct: 585 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 629



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 273 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHTFESHKDEIFQVHWSPHNETI 331
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 471 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 528

Query: 332 LASSGTDRRLNVW 344
           LAS   D ++ +W
Sbjct: 529 LASGSDDAKVKLW 541


>gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo
           sapiens]
          Length = 707

 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 13/167 (7%)

Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
           +SW+S     L S+  + TV LWD   G +         ++  H      V ++L+   L
Sbjct: 452 ISWSSYHKNLLASSDYEGTVILWDGFTGQRS-------KVYQEHEKRCWSVDFNLMDPKL 504

Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
             S +DD K+ +W T  + +      ++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 505 LASGSDDAKVKLWSTNLDNSVAS---IEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560

Query: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 348
           LRN K  +  F+ H+  +    +    E + AS  TD +L +W++ K
Sbjct: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 273 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHTFESHKDEIFQVHWSPHNETI 331
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504

Query: 332 LASSGTDRRLNVW 344
           LAS   D ++ +W
Sbjct: 505 LASGSDDAKVKLW 517


>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
           sapiens]
          Length = 387

 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 52/227 (22%), Positives = 96/227 (42%), Gaps = 21/227 (9%)

Query: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251
           ++S +D+H + LWD+     +  +  + ++            W   H     + A+D  L
Sbjct: 151 IISLADNH-ILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTL 209

Query: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 311
             WDTRS   S+   + +AH   V  L FNP  ++ LA+   D  V  WD RN+   + T
Sbjct: 210 RGWDTRS--MSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKT 267

Query: 312 FESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEE--------QSAEDAEDGPP 363
            E H   ++ V ++  ++ ++ +  +D R+ + ++  I  E            D ED   
Sbjct: 268 LEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRS 327

Query: 364 E----------LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQI 400
           E          ++  +  H   +    W+  +PW+  S+S D  + I
Sbjct: 328 EEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVI 374



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 45/208 (21%), Positives = 76/208 (36%), Gaps = 27/208 (12%)

Query: 203 LWDINAGPKEGKIVDAKAIFTGHSAVVEDVA-WHLLHESLFGS--VADDQKLMIWDTRSN 259
           +W I+A P +  ++      T  S V+   A W +  E   GS    DD       + + 
Sbjct: 67  IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121

Query: 260 TTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDE- 318
           T     HL +     + C+ + P  +       AD  + LWDL+    +     S   E 
Sbjct: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181

Query: 319 -----IFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHT 373
                     WSPH+     ++  D  L  WD   + +    E+A             H 
Sbjct: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA-------------HG 228

Query: 374 AKISDFSWNPNEPWVICSVSEDNIMQIW 401
             + D  +NPN+ + + S  +D  ++ W
Sbjct: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 39/168 (23%), Positives = 66/168 (39%), Gaps = 37/168 (22%)

Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
           L +N N   +L S  DD  V  WD         + +       HS  V +V ++  H+ L
Sbjct: 234 LDFNPNKQYYLASCGDDCKVKFWDTR------NVTEPVKTLEEHSHWVWNVRYNHSHDQL 287

Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVD--------AHTAEVNCLSFNPYSEFILATGSA 293
             + + D ++++ +  S ++    HLVD         H +E    S  P  + ++A    
Sbjct: 288 VLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEK--SKEPLQDNVIA---- 341

Query: 294 DKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341
                            T+E H+D ++ V WS  +  + AS   D RL
Sbjct: 342 -----------------TYEEHEDSVYAVDWSSADPWLFASLSYDGRL 372


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 57/233 (24%), Positives = 101/233 (43%), Gaps = 17/233 (7%)

Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
           H    +G  W+ N    + +  +D  V ++ +     +        +F+GH+A V  V W
Sbjct: 496 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQ-----PLKVFSGHTAKVFHVKW 550

Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
             L E +  S +DD  + IWD    T     ++++ HTA V  L +N    ++L +GS D
Sbjct: 551 SPLREGILCSGSDDGTVRIWDY---TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWD 607

Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQS 354
            T+ +WD R     + T   H  +++ +   P     +AS   D  + +W L+ +     
Sbjct: 608 YTIKVWDTRE-GTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQ 666

Query: 355 AEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC-SVSEDNIMQIWQMAEN 406
                D   E +    G+T    D++  P  P ++C  VS D   +I ++  N
Sbjct: 667 INILADRSWEEII---GNT----DYAIEPGTPPLLCGKVSRDIRQEIEKLTAN 712



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 66/299 (22%), Positives = 115/299 (38%), Gaps = 42/299 (14%)

Query: 120 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 179
           + H   +   ++ P +P+++AT +    + V+D     A     G             EG
Sbjct: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGN------------EG 413

Query: 180 --YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAV-VEDVAWHL 236
             Y LSW       +   +  +   +W++    ++GKI+     F  H    +  +AW  
Sbjct: 414 VIYSLSWAPGGLNCIAGGTSRNGAFIWNV----QKGKIIQR---FNEHGTNGIFCIAWSH 466

Query: 237 LHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKT 296
                  + + D   +I         K  H      A V    ++  ++ ++ATG  D  
Sbjct: 467 KDSKRIATCSSDGFCIIRTIDGKVLHKYKH-----PAAVFGCDWSQNNKDMIATGCEDTN 521

Query: 297 VALWDLRNLKLK-LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 355
           V ++ +     + L  F  H  ++F V WSP  E IL S   D  + +WD +        
Sbjct: 522 VRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYT-------- 573

Query: 356 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESD 414
           +DA       + I  GHTA +    WN   P+++ S S D  +++W   E    D   D
Sbjct: 574 QDA------CINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD 626



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 54/252 (21%), Positives = 105/252 (41%), Gaps = 32/252 (12%)

Query: 170 LRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT--GHSA 227
           LR  GH +  +   +  +    L +AS D T+ +WDIN            A++T  G+  
Sbjct: 363 LRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINT---------LTAVYTSPGNEG 413

Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
           V+  ++W     +            IW+ +     +  +  +  T  + C++++      
Sbjct: 414 VIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFN--EHGTNGIFCIAWSHKDSKR 471

Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 347
           +AT S+D       +R +  K+     H   +F   WS +N+ ++A+   D  + V+ ++
Sbjct: 472 IATCSSD---GFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVA 528

Query: 348 KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE-- 405
              ++             L +  GHTAK+    W+P    ++CS S+D  ++IW   +  
Sbjct: 529 TSSDQP------------LKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDA 576

Query: 406 --NIYNDEESDV 415
             NI N   + V
Sbjct: 577 CINILNGHTAPV 588



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 34/140 (24%), Positives = 55/140 (39%), Gaps = 17/140 (12%)

Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
           H  +V   ++ P    I+ + +    V ++DYT+                L GH     G
Sbjct: 541 HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINI----------LNGHTAPVRG 590

Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
           L WN+ +   L+S S D+T+ +WD     +EG  VD       H A V  +  H      
Sbjct: 591 LMWNTEIPYLLISGSWDYTIKVWD----TREGTCVDT---VYDHGADVYGLTCHPSRPFT 643

Query: 242 FGSVADDQKLMIWDTRSNTT 261
             S + D  + +W   +  T
Sbjct: 644 MASCSRDSTVRLWSLTALVT 663



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 29/105 (27%), Positives = 46/105 (43%), Gaps = 15/105 (14%)

Query: 301 DLRNLKLKLHTFES-HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 359
           D R  + KLH   S HK  I  + W PHN  + AS  TD  + +W++++  +  +  D+ 
Sbjct: 43  DHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-QKVIAKLDST 101

Query: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
            G P             +  SW  N   V+  VS    + IW ++
Sbjct: 102 KGIP-------------ASLSWCWNAEDVVAFVSHRGPLFIWTIS 133



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 25/122 (20%), Positives = 53/122 (43%), Gaps = 17/122 (13%)

Query: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326
           ++  H   +  +S+ P++  + A+GS D  V +W++   K+ +   +S K     + W  
Sbjct: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKV-IAKLDSTKGIPASLSWCW 112

Query: 327 HNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISD---FSWNP 383
           + E ++A       L +W +S             GP   + +H    + +SD   F W+ 
Sbjct: 113 NAEDVVAFVSHRGPLFIWTIS-------------GPDSGVIVHKDAHSFLSDICMFRWHT 159

Query: 384 NE 385
           ++
Sbjct: 160 HQ 161



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 14/34 (41%), Positives = 20/34 (58%)

Query: 372 HTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
           H   I+  SW P+ P +  S S DN++ IW +AE
Sbjct: 58  HKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE 91


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 57/233 (24%), Positives = 101/233 (43%), Gaps = 17/233 (7%)

Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
           H    +G  W+ N    + +  +D  V ++ +     +        +F+GH+A V  V W
Sbjct: 520 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQ-----PLKVFSGHTAKVFHVKW 574

Query: 235 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 294
             L E +  S +DD  + IWD    T     ++++ HTA V  L +N    ++L +GS D
Sbjct: 575 SPLREGILCSGSDDGTVRIWDY---TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWD 631

Query: 295 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQS 354
            T+ +WD R     + T   H  +++ +   P     +AS   D  + +W L+ +     
Sbjct: 632 YTIKVWDTRE-GTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQ 690

Query: 355 AEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC-SVSEDNIMQIWQMAEN 406
                D   E +    G+T    D++  P  P ++C  VS D   +I ++  N
Sbjct: 691 INILADRSWEEII---GNT----DYAIEPGTPPLLCGKVSRDIRQEIEKLTAN 736



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 66/299 (22%), Positives = 115/299 (38%), Gaps = 42/299 (14%)

Query: 120 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 179
           + H   +   ++ P +P+++AT +    + V+D     A     G             EG
Sbjct: 390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGN------------EG 437

Query: 180 --YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAV-VEDVAWHL 236
             Y LSW       +   +  +   +W++    ++GKI+     F  H    +  +AW  
Sbjct: 438 VIYSLSWAPGGLNCIAGGTSRNGAFIWNV----QKGKIIQR---FNEHGTNGIFCIAWSH 490

Query: 237 LHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKT 296
                  + + D   +I         K  H      A V    ++  ++ ++ATG  D  
Sbjct: 491 KDSKRIATCSSDGFCIIRTIDGKVLHKYKH-----PAAVFGCDWSQNNKDMIATGCEDTN 545

Query: 297 VALWDLRNLKLK-LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 355
           V ++ +     + L  F  H  ++F V WSP  E IL S   D  + +WD +        
Sbjct: 546 VRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYT-------- 597

Query: 356 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESD 414
           +DA       + I  GHTA +    WN   P+++ S S D  +++W   E    D   D
Sbjct: 598 QDA------CINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD 650



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 54/252 (21%), Positives = 105/252 (41%), Gaps = 32/252 (12%)

Query: 170 LRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT--GHSA 227
           LR  GH +  +   +  +    L +AS D T+ +WDIN            A++T  G+  
Sbjct: 387 LRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINT---------LTAVYTSPGNEG 437

Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
           V+  ++W     +            IW+ +     +  +  +  T  + C++++      
Sbjct: 438 VIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFN--EHGTNGIFCIAWSHKDSKR 495

Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 347
           +AT S+D       +R +  K+     H   +F   WS +N+ ++A+   D  + V+ ++
Sbjct: 496 IATCSSD---GFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVA 552

Query: 348 KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE-- 405
              ++             L +  GHTAK+    W+P    ++CS S+D  ++IW   +  
Sbjct: 553 TSSDQP------------LKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDA 600

Query: 406 --NIYNDEESDV 415
             NI N   + V
Sbjct: 601 CINILNGHTAPV 612



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 34/140 (24%), Positives = 55/140 (39%), Gaps = 17/140 (12%)

Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
           H  +V   ++ P    I+ + +    V ++DYT+                L GH     G
Sbjct: 565 HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINI----------LNGHTAPVRG 614

Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
           L WN+ +   L+S S D+T+ +WD     +EG  VD       H A V  +  H      
Sbjct: 615 LMWNTEIPYLLISGSWDYTIKVWD----TREGTCVDT---VYDHGADVYGLTCHPSRPFT 667

Query: 242 FGSVADDQKLMIWDTRSNTT 261
             S + D  + +W   +  T
Sbjct: 668 MASCSRDSTVRLWSLTALVT 687



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 29/105 (27%), Positives = 46/105 (43%), Gaps = 15/105 (14%)

Query: 301 DLRNLKLKLHTFES-HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 359
           D R  + KLH   S HK  I  + W PHN  + AS  TD  + +W++++  +  +  D+ 
Sbjct: 67  DHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-QKVIAKLDST 125

Query: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 404
            G P             +  SW  N   V+  VS    + IW ++
Sbjct: 126 KGIP-------------ASLSWCWNAEDVVAFVSHRGPLFIWTIS 157



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 25/122 (20%), Positives = 53/122 (43%), Gaps = 17/122 (13%)

Query: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326
           ++  H   +  +S+ P++  + A+GS D  V +W++   K+ +   +S K     + W  
Sbjct: 78  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKV-IAKLDSTKGIPASLSWCW 136

Query: 327 HNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISD---FSWNP 383
           + E ++A       L +W +S             GP   + +H    + +SD   F W+ 
Sbjct: 137 NAEDVVAFVSHRGPLFIWTIS-------------GPDSGVIVHKDAHSFLSDICMFRWHT 183

Query: 384 NE 385
           ++
Sbjct: 184 HQ 185



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 14/34 (41%), Positives = 20/34 (58%)

Query: 372 HTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
           H   I+  SW P+ P +  S S DN++ IW +AE
Sbjct: 82  HKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE 115


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 64/283 (22%), Positives = 112/283 (39%), Gaps = 63/283 (22%)

Query: 174 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVA 233
           GHQ+    ++W S    +L SAS D T C+W  N    E           GH   V+ VA
Sbjct: 59  GHQRTVRKVAW-SPCGNYLASASFDATTCIWKKNQDDFE-----CVTTLEGHENEVKSVA 112

Query: 234 WHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 293
           W     +L  + + D+ + +W+       +   ++++HT +V  + ++P S+ +LA+ S 
Sbjct: 113 W-APSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP-SQELLASASY 170

Query: 294 DKTVALW-DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEE 352
           D TV L+ +  +  +   T E H+  ++ + + P  +  LAS   DR + +W     G E
Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNE 229

Query: 353 QSA------------------------------------------------EDAEDGPPE 364
           Q                                                  ED    P +
Sbjct: 230 QGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQ 289

Query: 365 LLF-----IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 402
             F     +H  H+  ++  +WNP EP ++ S S+D  +  W+
Sbjct: 290 PTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 41/186 (22%), Positives = 78/186 (41%), Gaps = 34/186 (18%)

Query: 240 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 299
           +L  S   D+++ IW T  ++    S L + H   V  ++++P   + LA+ S D T  +
Sbjct: 29  TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY-LASASFDATTCI 87

Query: 300 WDLRNLKLK-LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDA 358
           W       + + T E H++E+  V W+P    +LA+   D+ + VW++            
Sbjct: 88  WKKNQDDFECVTTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVWEVD----------- 135

Query: 359 EDGPPELLFIHGGHTAKISDFSWNPNEP--------------------WVICSVSEDNIM 398
           E+   E + +   HT  +    W+P++                     WV C+  E +  
Sbjct: 136 EEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHES 195

Query: 399 QIWQMA 404
            +W +A
Sbjct: 196 TVWSLA 201



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 15/143 (10%)

Query: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLW-DINAGPKEGKIVDA-----KAIFT-- 223
           L GH+   + L+++ +    L S SDD TV +W     G ++G          K I T  
Sbjct: 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248

Query: 224 -GHSAVVEDVAWHLLHESLFGSVADD-----QKLMIWDTRSNTTSKPSHLVDAHTAEVNC 277
             HS  + D+AW  L  +L  +  DD     Q+    D +  T S  +HL  AH+ +VNC
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308

Query: 278 LSFNPYSEFILATGSADKTVALW 300
           +++NP    +LA+ S D  VA W
Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 17/96 (17%)

Query: 324 WSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNP 383
           W+P   T+LAS G DRR+ +W     G E  +   +        +  GH   +   +W+P
Sbjct: 24  WNPAG-TLLASCGGDRRIRIW-----GTEGDSWICKS------VLSEGHQRTVRKVAWSP 71

Query: 384 NEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSE 419
              + + S S D    IW+  +    D+   VTT E
Sbjct: 72  CGNY-LASASFDATTCIWKKNQ----DDFECVTTLE 102


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 76/291 (26%), Positives = 131/291 (45%), Gaps = 36/291 (12%)

Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
           H G V +    PQ P +I + +    ++++  T+     D +    P   LRGH      
Sbjct: 14  HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVSD 68

Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
           +  +S+     LS S D T+ LWD+  G    +       F GH+  V  VA+   +  +
Sbjct: 69  VVISSD-GQFALSGSWDGTLRLWDLTTGTTTRR-------FVGHTKDVLSVAFSSDNRQI 120

Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEF-ILATGSADKTVALW 300
             S + D+ + +W+T      K +   ++H+  V+C+ F+P S   I+ +   DK V +W
Sbjct: 121 V-SGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177

Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 360
           +L N KLK +    H   +  V  SP + ++ AS G D +  +WDL++            
Sbjct: 178 NLANCKLKTNHI-GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNE------------ 223

Query: 361 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 411
               L  + GG    I+   ++PN  W +C+ +  +I +IW +   I  DE
Sbjct: 224 -GKHLYTLDGGDI--INALCFSPNRYW-LCAATGPSI-KIWDLEGKIIVDE 269


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 49/153 (32%), Positives = 79/153 (51%), Gaps = 13/153 (8%)

Query: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251
           L+S SDD T+ LW     P E K    +   TGH A++  V +      +  S + D+ +
Sbjct: 52  LVSGSDDFTLFLWS----PAEDKKPLTR--MTGHQALINQVLFSP-DSRIVASASFDKSI 104

Query: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 311
            +WD R   T K    +  H A V  ++++  S  +L +GS+D T+ +WD++  KL +  
Sbjct: 105 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 159

Query: 312 FESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
              H DE++ V WSP  + + AS G D+ L +W
Sbjct: 160 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 191



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 31/116 (26%), Positives = 54/116 (46%), Gaps = 16/116 (13%)

Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 347
           L +GS D T+ LW     K  L     H+  I QV +SP +  I+AS+  D+ + +WD  
Sbjct: 52  LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-G 109

Query: 348 KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
           + G             + L    GH A +   +W+ +   ++ S S D+ +++W +
Sbjct: 110 RTG-------------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDV 151


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 49/153 (32%), Positives = 79/153 (51%), Gaps = 13/153 (8%)

Query: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251
           L+S SDD T+ LW     P E K    +   TGH A++  V +      +  S + D+ +
Sbjct: 344 LVSGSDDFTLFLWS----PAEDKKPLTR--MTGHQALINQVLFSP-DSRIVASASFDKSI 396

Query: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 311
            +WD R   T K    +  H A V  ++++  S  +L +GS+D T+ +WD++  KL +  
Sbjct: 397 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 451

Query: 312 FESHKDEIFQVHWSPHNETILASSGTDRRLNVW 344
              H DE++ V WSP  + + AS G D+ L +W
Sbjct: 452 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 483



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 66/288 (22%), Positives = 107/288 (37%), Gaps = 73/288 (25%)

Query: 161 DPSGECNPDLRLRGHQKEGYGLSWNSNLSG----HLLSASDDHTVCLWDINAGPKEGKIV 216
           DPS        L GH K   GLSW    +     ++ S+S D +V +WD  AG  E    
Sbjct: 184 DPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCE---- 239

Query: 217 DAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVN 276
               I TGH+  V  + W    + L  S + D+ + +W        +    +  H   VN
Sbjct: 240 ---RILTGHTQSVTCLRWG--GDGLLYSASQDRTIKVWRAHDGVLCR---TLQGHGHWVN 291

Query: 277 CL-----------SFNPYSEFI------------------------------LATGSADK 295
            +           +F P    +                              L +GS D 
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDF 351

Query: 296 TVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 355
           T+ LW     K  L     H+  I QV +SP +  I+AS+  D+ + +WD  + G     
Sbjct: 352 TLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-GRTG----- 404

Query: 356 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
                   + L    GH A +   +W+ +   ++ S S D+ +++W +
Sbjct: 405 --------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDV 443



 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 24/176 (13%)

Query: 257 RSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHK 316
           R    ++ +  ++ H+  V  ++F+P  ++ LA+GS D TV  WDL + +    T + H+
Sbjct: 99  RVRAVTRCTSSLEGHSEAVISVAFSPTGKY-LASGSGDTTVRFWDL-STETPHFTCKGHR 156

Query: 317 DEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKI 376
             +  + WSP     LAS   + ++ +WD S  G++     A            GH+  I
Sbjct: 157 HWVLSISWSPDGRK-LASGCKNGQILLWDPS-TGKQVGRTLA------------GHSKWI 202

Query: 377 SDFSWNP----NEPWVICSVSEDNIMQIWQ----MAENIYNDEESDVTTSELEGQG 424
           +  SW P     E   + S S+D  ++IW       E I       VT     G G
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG 258


>gi|109627650 coronin 6 [Homo sapiens]
          Length = 472

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 48/188 (25%), Positives = 89/188 (47%), Gaps = 15/188 (7%)

Query: 211 KEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWD----TRSNTTSKPSH 266
           K G++     + TGH+A V D+ W   ++++  S +DD  +M+W     T     ++P  
Sbjct: 66  KTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPII 125

Query: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326
            ++ H+  V  LS++P +  +L +   D  + +W++   ++ L   + H D I  V W+ 
Sbjct: 126 TLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWN- 184

Query: 327 HNETILASSGTDRRLNVWDLSK--IGEEQSAEDAEDGPPELLFIHGGH--TAKISDFS-- 380
            N ++LA++  D+ L + D  K  +  E+ A      P   +F   GH  T   +  S  
Sbjct: 185 SNGSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQGHIFTTGFTRMSQR 244

Query: 381 ----WNPN 384
               W+PN
Sbjct: 245 ELGLWDPN 252



 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 10/198 (5%)

Query: 174 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVA 233
           GH      + W  +    + SASDD T+ +W I        I +      GHS  V  ++
Sbjct: 79  GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILS 138

Query: 234 WHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 293
           WH    ++  S   D  ++IW+    T      L D H   ++ + +N     +LAT   
Sbjct: 139 WHPTARNVLLSAGGDNVIIIWNV--GTGEVLLSLDDMHPDVIHSVCWNSNGS-LLATTCK 195

Query: 294 DKTVALWDLRNLKLKLHTFESHKD-----EIFQVHWSPHNETILASSGTDRRLNVWDLSK 348
           DKT+ + D R  ++    F +H+       +F      H  T   +  + R L +WD + 
Sbjct: 196 DKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFT--RQGHIFTTGFTRMSQRELGLWDPNN 253

Query: 349 IGEEQSAEDAEDGPPELL 366
             E  + ++ +     LL
Sbjct: 254 FEEPVALQEMDTSNGVLL 271



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 18/152 (11%)

Query: 111 TGKIECEIKI--NHEGEVNRARYMPQNPHIIATKTPSSDVLVF---DYTKHPAKPDPSGE 165
           TG+++    +   H   V    + P N ++IA+ +  + ++V+   DYT  P +      
Sbjct: 67  TGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYT--PMR----NI 120

Query: 166 CNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGH 225
             P + L GH K    LSW+      LLSA  D+ + +W++  G     + D       H
Sbjct: 121 TEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDM------H 174

Query: 226 SAVVEDVAWHLLHESLFGSVADDQKLMIWDTR 257
             V+  V W+  + SL  +   D+ L I D R
Sbjct: 175 PDVIHSVCWN-SNGSLLATTCKDKTLRIIDPR 205



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 22/89 (24%), Positives = 41/89 (46%), Gaps = 7/89 (7%)

Query: 315 HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTA 374
           H   +  + W PHN+ ++AS+  D  + VW +      ++         E +    GH+ 
Sbjct: 80  HTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNIT-------EPIITLEGHSK 132

Query: 375 KISDFSWNPNEPWVICSVSEDNIMQIWQM 403
           ++   SW+P    V+ S   DN++ IW +
Sbjct: 133 RVGILSWHPTARNVLLSAGGDNVIIIWNV 161



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 14/35 (40%), Positives = 21/35 (60%)

Query: 371 GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
           GHTA + D  W P+   VI S S+D  + +WQ+ +
Sbjct: 79  GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPD 113


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 72/312 (23%), Positives = 127/312 (40%), Gaps = 61/312 (19%)

Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
           HEGEV   ++ P    + +      D L+  +  +       G+C+    L+GH      
Sbjct: 65  HEGEVYCCKFHPNGSTLASA---GFDRLILLWNVY-------GDCDNYATLKGHSGAVME 114

Query: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
           L +N++ S  L SAS D TV +WD   G +  ++        GH++ V           L
Sbjct: 115 LHYNTDGS-MLFSASTDKTVAVWDSETGERVKRL-------KGHTSFVNSCYPARRGPQL 166

Query: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
             + +DD  + +WD R     +       +T +V  ++FN  S+ I++ G  D  + +WD
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQ----NTYQVLAVTFNDTSDQIIS-GGIDNDIKVWD 221

Query: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDL--------------- 346
           LR  KL  +T   H D +  +  S     +L S+  D  + VWD+               
Sbjct: 222 LRQNKLT-YTMRGHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRPFAPKERCVKIFQG 279

Query: 347 --------------SKIGEEQSAEDAE-------DGPPELLFIHGGHTAKISDFSWNPNE 385
                         S  G + +A  A+            +L+   GH   I++ +++P+E
Sbjct: 280 NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339

Query: 386 PWVICSVSEDNI 397
           P +I + S+  +
Sbjct: 340 PIIISASSDKRL 351



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 64/238 (26%), Positives = 106/238 (44%), Gaps = 33/238 (13%)

Query: 168 PDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSA 227
           P + L GH+ E Y   ++ N S  L SA  D  + LW++          D  A   GHS 
Sbjct: 58  PIMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGD------CDNYATLKGHSG 110

Query: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
            V ++ ++     LF S + D+ + +WD+ +    K    +  HT+ VN          +
Sbjct: 111 AVMELHYNTDGSMLF-SASTDKTVAVWDSETGERVKR---LKGHTSFVNSCYPARRGPQL 166

Query: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETI--LASSGTDRRLNVWD 345
           + TGS D TV LWD+R  K  + TF++     +QV     N+T   + S G D  + VWD
Sbjct: 167 VCTGSDDGTVKLWDIRK-KAAIQTFQN----TYQVLAVTFNDTSDQIISGGIDNDIKVWD 221

Query: 346 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
           L +               +L +   GH   ++  S + +E   + S + DN +++W +
Sbjct: 222 LRQ--------------NKLTYTMRGHADSVTGLSLS-SEGSYLLSNAMDNTVRVWDV 264



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 35/147 (23%), Positives = 68/147 (46%), Gaps = 16/147 (10%)

Query: 257 RSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHK 316
           R ++   P  L+  H  EV C  F+P     LA+   D+ + LW++        T + H 
Sbjct: 51  RCSSLQAPIMLLSGHEGEVYCCKFHPNGS-TLASAGFDRLILLWNVYGDCDNYATLKGHS 109

Query: 317 DEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKI 376
             + ++H++  + ++L S+ TD+ + VWD S+ GE                   GHT+ +
Sbjct: 110 GAVMELHYNT-DGSMLFSASTDKTVAVWD-SETGERVKRLK-------------GHTSFV 154

Query: 377 SDFSWNPNEPWVICSVSEDNIMQIWQM 403
           +        P ++C+ S+D  +++W +
Sbjct: 155 NSCYPARRGPQLVCTGSDDGTVKLWDI 181


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 64/247 (25%), Positives = 106/247 (42%), Gaps = 32/247 (12%)

Query: 167 NPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEG--KIVDAKAIFTG 224
           N  + LRGH+ E +  +WN  +S  L S S D T  +W+++     G  ++V    I  G
Sbjct: 160 NKAVVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218

Query: 225 HSAV-----VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLS 279
              V     V  + W+    +L  + + D    IW    N  S     +  H   +  L 
Sbjct: 219 GQDVPSNKDVTSLDWN-SEGTLLATGSYDGFARIWTKDGNLAS----TLGQHKGPIFALK 273

Query: 280 FNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDR 339
           +N    FIL+ G  DKT  +WD    + K   F  H      V W  +N    AS  TD 
Sbjct: 274 WNKKGNFILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDWQSNN--TFASCSTDM 329

Query: 340 RLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 399
            ++V    K+G+++  +  +           GHT +++   W+P    ++ S S+D  ++
Sbjct: 330 CIHV---CKLGQDRPIKTFQ-----------GHTNEVNAIKWDPTGN-LLASCSDDMTLK 374

Query: 400 IWQMAEN 406
           IW M ++
Sbjct: 375 IWSMKQD 381



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 55/219 (25%), Positives = 87/219 (39%), Gaps = 61/219 (27%)

Query: 175 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 234
           H+   + L WN      +LSA  D T  +WD + G       +AK  F  HSA   DV W
Sbjct: 265 HKGPIFALKWNKK-GNFILSAGVDKTTIIWDAHTG-------EAKQQFPFHSAPALDVDW 316

Query: 235 H------------LLHE----------------------------SLFGSVADDQKLMIW 254
                         +H                             +L  S +DD  L IW
Sbjct: 317 QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376

Query: 255 DTRSNTTSKPSHLVDAHTAEVNCLSF--------NPYSEFILATGSADKTVALWDLRNLK 306
             + +      H + AH  E+  + +        NP +  +LA+ S D TV LWD+ +  
Sbjct: 377 SMKQDNCV---HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV-DRG 432

Query: 307 LKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 345
           + +HT   H++ ++ V +SP     LAS   D+ +++W+
Sbjct: 433 ICIHTLTKHQEPVYSVAFSPDGR-YLASGSFDKCVHIWN 470



 Score = 36.6 bits (83), Expect = 0.044
 Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%)

Query: 308 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 367
           K      H+ E+F   W+P ++ +LAS   D    +W+LS        E++  G  +L+ 
Sbjct: 161 KAVVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLS--------ENSTSGSTQLVL 211

Query: 368 IH----GGH----TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 407
            H    GG        ++   WN +E  ++ + S D   +IW    N+
Sbjct: 212 RHCIREGGQDVPSNKDVTSLDWN-SEGTLLATGSYDGFARIWTKDGNL 258



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 47/187 (25%), Positives = 70/187 (37%), Gaps = 69/187 (36%)

Query: 172 LRGHQKEGYGLSW--------NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT 223
           L+ H KE Y + W        N N +  L SAS D TV LWD++ G              
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRG-------------- 432

Query: 224 GHSAVVEDVAWHLL--HESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFN 281
                   +  H L  H+    SVA                                 F+
Sbjct: 433 --------ICIHTLTKHQEPVYSVA---------------------------------FS 451

Query: 282 PYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341
           P   + LA+GS DK V +W+ +   L +H++      IF+V W+   + +  +S +D  +
Sbjct: 452 PDGRY-LASGSFDKCVHIWNTQTGAL-VHSYRG-TGGIFEVCWNAAGDKV-GASASDGSV 507

Query: 342 NVWDLSK 348
            V DL K
Sbjct: 508 CVLDLRK 514



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 14/45 (31%), Positives = 25/45 (55%), Gaps = 1/45 (2%)

Query: 362 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 406
           PP    +  GH +++   +WNP    ++ S S D+  +IW ++EN
Sbjct: 158 PPNKAVVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLSEN 201


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 60/225 (26%), Positives = 104/225 (46%), Gaps = 26/225 (11%)

Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLR-LRGHQKEGY 180
           H G V   R+ P   H+ A+ +    V ++D  +         +C   LR L+GHQ+   
Sbjct: 62  HTGPVKFCRFSPDG-HLFASASCDCTVRLWDVAR--------AKC---LRVLKGHQRSVE 109

Query: 181 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
            +S++ + S  L S   D  V LWD+ +G           +  GH   ++   +      
Sbjct: 110 TVSFSPD-SRQLASGGWDKRVMLWDVQSG-------QMLRLLVGHRDSIQSSDFSPTVNC 161

Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
           L  + + D  + IWD R  T +     ++ H+A ++CL ++  +  +LA+GS DKT+ +W
Sbjct: 162 L-ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS--ASGLLASGSWDKTIHIW 218

Query: 301 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 345
                 L +   + H   +  + +SP +E  LAS+G  R + VWD
Sbjct: 219 KPTTSSLLIQ-LKGHVTWVKSIAFSP-DELWLASAGYSRMVKVWD 261



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 75/283 (26%), Positives = 117/283 (41%), Gaps = 45/283 (15%)

Query: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181
           H GEVN + + P    ++   T S D  V+ +         SG+     RL GH   G  
Sbjct: 20  HGGEVNSSAFSPDGQMLL---TGSEDGCVYGWETR------SGQLL--WRLGGHT--GPV 66

Query: 182 LSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 240
                +  GHL  SAS D TV LWD+              +  GH   VE V++      
Sbjct: 67  KFCRFSPDGHLFASASCDCTVRLWDVARAK-------CLRVLKGHQRSVETVSFSPDSRQ 119

Query: 241 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 300
           L  S   D+++M+WD +S    +   L+  H   +    F+P     LATGS D TV +W
Sbjct: 120 L-ASGGWDKRVMLWDVQSGQMLR---LLVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIW 174

Query: 301 DLRNL--KLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDA 358
           DLR +   +     E H   I  + +S     +LAS   D+ +++W              
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIW-------------- 218

Query: 359 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 401
           +     LL    GH   +   +++P+E W + S     ++++W
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELW-LASAGYSRMVKVW 260


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,155,573
Number of Sequences: 37866
Number of extensions: 843606
Number of successful extensions: 3075
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 182
Number of HSP's that attempted gapping in prelim test: 1591
Number of HSP's gapped (non-prelim): 964
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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