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Search of human proteins with 4506411
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
(587 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 1132 0.0
gi|118918429 NOD3 protein [Homo sapiens] 93 8e-19
gi|17975763 myelin transcription factor 1 [Homo sapiens] 81 2e-15
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 77 4e-14
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami... 76 1e-13
gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 75 2e-13
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 72 1e-12
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 71 3e-12
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 67 5e-11
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 66 1e-10
gi|169210053 PREDICTED: hypothetical protein [Homo sapiens] 65 1e-10
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 65 2e-10
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 65 2e-10
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 65 2e-10
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 64 4e-10
gi|215422388 death-domain associated protein isoform a [Homo sap... 64 4e-10
gi|215422366 death-domain associated protein isoform b [Homo sap... 64 4e-10
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 64 4e-10
gi|211904182 DDB1 and CUL4 associated factor 8-like 2 [Homo sapi... 64 5e-10
gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 64 5e-10
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ... 63 7e-10
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ... 63 7e-10
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ... 63 7e-10
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 62 1e-09
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 62 1e-09
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 62 1e-09
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 62 1e-09
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 62 1e-09
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] 62 1e-09
gi|118600967 shroom family member 4 [Homo sapiens] 62 2e-09
>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
Length = 587
Score = 1132 bits (2929), Expect = 0.0
Identities = 587/587 (100%), Positives = 587/587 (100%)
Query: 1 MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNT 60
MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNT
Sbjct: 1 MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNT 60
Query: 61 VGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLS 120
VGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLS
Sbjct: 61 VGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLS 120
Query: 121 DNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPL 180
DNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPL
Sbjct: 121 DNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPL 180
Query: 181 ALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRV 240
ALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRV
Sbjct: 181 ALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRV 240
Query: 241 INLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNL 300
INLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNL
Sbjct: 241 INLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNL 300
Query: 301 SFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDD 360
SFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDD
Sbjct: 301 SFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDD 360
Query: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTG 420
EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTG
Sbjct: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTG 420
Query: 421 EPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVF 480
EPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVF
Sbjct: 421 EPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVF 480
Query: 481 KDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLM 540
KDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLM
Sbjct: 481 KDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLM 540
Query: 541 ALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV 587
ALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV
Sbjct: 541 ALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV 587
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 92.8 bits (229), Expect = 8e-19
Identities = 81/341 (23%), Positives = 151/341 (44%), Gaps = 36/341 (10%)
Query: 29 SLKLNTAED--AKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSD 86
SL+ NT D A+ + + + +L L L+ N++G A+ +A AL++ LK +S
Sbjct: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSS 787
Query: 87 MFTGRLRTEIPPALISLGEGLITAGAQ---------------------LVELDLSDNAFG 125
G + + + +GL + Q L+ L L +N+
Sbjct: 788 NSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSIS 847
Query: 126 PDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVF 185
P+G Q L +++ TL+ L L + G + +A A+ E +S +
Sbjct: 848 PEGAQAIAHALCANS--TLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQ------- 898
Query: 186 VAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLND 245
N ++ A AL +A ++ +L + + +N I G A+A+A VN L + L
Sbjct: 899 ---WNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQV 955
Query: 246 NTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEI 305
+ GA + E L R +E+++ + GA A+A+A++ L+ LNL +
Sbjct: 956 ASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVN-SSLRRLNLQENSL 1014
Query: 306 KRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLE 346
D A+ +A A++ L+ ++L GN +G+ G + E ++
Sbjct: 1015 GMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIK 1055
Score = 89.4 bits (220), Expect = 9e-18
Identities = 85/326 (26%), Positives = 138/326 (42%), Gaps = 60/326 (18%)
Query: 13 LAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKA 72
+ K +A Q+S KG AK + + + SL +L L GN++G + A+ +A A
Sbjct: 668 IQKISLAENQISNKG----------AKALARSLLVNRSLTSLDLRGNSIGPQGAKALADA 717
Query: 73 LEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGF 132
L+ L L L N DG +
Sbjct: 718 LK-----------------------------------INRTLTSLSLQGNTVRDDGARSM 742
Query: 133 EALLKSSACFTLQELKLNNCG-MGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNR 191
L S+ ++ L+ N+ G MG R + A + +LK + N
Sbjct: 743 AEALASNRTLSMLHLQKNSIGPMG-------------AQRMADALKQNRSLKELMFSSNS 789
Query: 192 LENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEK 251
+ + GA ALAEA +V LE + + N I+ G+ AL A N L ++L +N+ + +
Sbjct: 790 IGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPE 849
Query: 252 GAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAAL 311
GA A+A L ++ ++ L+ +GA AIA A+R L L+L + I+ AA
Sbjct: 850 GAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVREN-RTLTSLHLQWNFIQAGAAQ 908
Query: 312 AVAEAMADKAELEKLDLNGNTLGEEG 337
A+ +A+ L LDL N +G++G
Sbjct: 909 ALGQALQLNRSLTSLDLQENAIGDDG 934
Score = 79.7 bits (195), Expect = 7e-15
Identities = 56/173 (32%), Positives = 83/173 (47%), Gaps = 1/173 (0%)
Query: 173 SSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAF 232
S GK ++ N++ N GA ALA + V +L + + N I G ALA A
Sbjct: 659 SVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADAL 718
Query: 233 AVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGL 292
+N L ++L NT + GA +MAE L + R + +++ + GA +ADA++
Sbjct: 719 KINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQN- 777
Query: 293 PKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVL 345
LKEL S I A A+AEA+ LE LDL N++ + G L L
Sbjct: 778 RSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGAL 830
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/246 (28%), Positives = 101/246 (41%), Gaps = 51/246 (20%)
Query: 50 SLEALRLEGNTVGVEAARVIAKALEKKSELKRCH--WSDMFTGRLRTEIPPALISLGEGL 107
+L+ L L N + + AR IA A+ + L H W+ + G A +LG+ L
Sbjct: 863 TLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAG--------AAQALGQAL 914
Query: 108 ITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALT 167
L LDL +NA G DG AC + LK+N ALT
Sbjct: 915 -QLNRSLTSLDLQENAIGDDG-----------ACAVARALKVNT-------------ALT 949
Query: 168 ECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITA 227
+ + ++ G GA L EA V TLE + + N I G A
Sbjct: 950 ALYLQVASIGA----------------SGAQVLGEALAVNRTLEILDLRGNAIGVAGAKA 993
Query: 228 LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADA 287
LA A VN LR +NL +N+ GA+ +A L +++ IN + GA I++A
Sbjct: 994 LANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEA 1053
Query: 288 IRGGLP 293
I+ P
Sbjct: 1054 IKTNAP 1059
Score = 35.4 bits (80), Expect = 0.15
Identities = 19/65 (29%), Positives = 38/65 (58%), Gaps = 3/65 (4%)
Query: 294 KLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKV 353
++++++L+ +I A A+A ++ L LDL GN++G +G + L + L+ + +
Sbjct: 667 RIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALK---INRT 723
Query: 354 LASLS 358
L SLS
Sbjct: 724 LTSLS 728
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 81.3 bits (199), Expect = 2e-15
Identities = 54/134 (40%), Positives = 73/134 (54%), Gaps = 19/134 (14%)
Query: 338 CEQLQEVLEGFNMAKVLASLS-DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEE 396
C Q E +K LS ++EDEEEEEE EEEEE+ EEEEEE+EEEEEEEEEEEEE
Sbjct: 236 CPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEE 295
Query: 397 EPQQRGQGEKSATPS---RKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKS 453
E ++ + E+ A P ++ + + AP L P PSP+ P+
Sbjct: 296 EEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPES---------PSPK------PEY 340
Query: 454 SVLIAQQTDTSDPE 467
SV++ ++D E
Sbjct: 341 SVIVEVRSDDDKDE 354
Score = 52.8 bits (125), Expect = 9e-07
Identities = 29/71 (40%), Positives = 41/71 (57%)
Query: 336 EGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEE 395
E E++ EV + SL D EE ++ E E+EEEE+EEEEEEE+EEEE
Sbjct: 219 EDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEE 278
Query: 396 EEPQQRGQGEK 406
EE ++ + E+
Sbjct: 279 EEEEEEEEEEE 289
Score = 47.0 bits (110), Expect = 5e-05
Identities = 31/105 (29%), Positives = 53/105 (50%), Gaps = 1/105 (0%)
Query: 312 AVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEE 371
++ +A ++++ +K L+ EE E+ +E E + ++E+EEEEEE EE
Sbjct: 239 SLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEE 298
Query: 372 EEEEAEEEEEEDE-EEEEEEEEEEEEEPQQRGQGEKSATPSRKIL 415
EEEE EEE D +E+ ++ P+ RG S P ++
Sbjct: 299 EEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVI 343
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 77.0 bits (188), Expect = 4e-14
Identities = 52/130 (40%), Positives = 70/130 (53%), Gaps = 16/130 (12%)
Query: 291 GLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNM 350
GLP+ L+L + + KRD ++D E +L N + G + +
Sbjct: 674 GLPRAVPLSLPYQDFKRD--------LSDYRERARLL---NRVRRVGFSHMLLTTPQVPL 722
Query: 351 AKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATP 410
A V + E+EEEEEE EEEEEE EEEEEE+EEEEEEEEEEEEEE + +A
Sbjct: 723 APVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEE-----AAAAVA 777
Query: 411 SRKILDPNTG 420
++L P +G
Sbjct: 778 LGEVLGPRSG 787
Score = 32.7 bits (73), Expect = 0.95
Identities = 41/147 (27%), Positives = 54/147 (36%), Gaps = 31/147 (21%)
Query: 359 DDEDEEEEEEGEEEEEEA---------EEEEEEDEEEEEEEEEEEEEEP-------QQRG 402
++E+EEEEEE EEEE A E E + +E P Q+
Sbjct: 757 EEEEEEEEEEEEEEEAAAAVALGEVLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKES 816
Query: 403 QGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPE----KLLRLGPKSS--VL 456
+G S L+P G VL SP S A +P+ L L P+
Sbjct: 817 RGRASMADGD--LEPEEGSKTLVLVSPGDMKKSPVTAELAPDPDLGTLAALTPQHERPQP 874
Query: 457 IAQQTDTSDPEKVVSAFLKVSSVFKDE 483
Q D S+P +SSV K E
Sbjct: 875 TGSQLDVSEPG-------TLSSVLKSE 894
>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member E isoform 1 [Homo sapiens]
Length = 268
Score = 75.9 bits (185), Expect = 1e-13
Identities = 65/187 (34%), Positives = 99/187 (52%), Gaps = 32/187 (17%)
Query: 243 LNDNTFTEKGAVAMAET-------LKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKL 295
LND TF E ++MA L +L ++ + D ++ S G +A+ P L
Sbjct: 37 LND-TFKELEFLSMANVELSSLARLPSLNKLRKLELSDNII-SGGLEVLAEKC----PNL 90
Query: 296 KELNLSFCEIKRDAALAVAEAMADKAELEKLDL------NGNTLGEEGCEQLQEV--LEG 347
LNLS +IK L+ EA+ + L+ LDL N E E LQ++ L+G
Sbjct: 91 TYLNLSGNKIKD---LSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDG 147
Query: 348 FNMAKVLASLSDDEDEEEEEEGEEEEEEAE--------EEEEEDEEEEEEEEEEEEEEPQ 399
F+ A S++ED+E+ +E +EEEEE E EEEEE+EEE+E+E+E+E+E
Sbjct: 148 FDQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGS 207
Query: 400 QRGQGEK 406
+ G+GE+
Sbjct: 208 ELGEGEE 214
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/82 (35%), Positives = 43/82 (52%), Gaps = 4/82 (4%)
Query: 315 EAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEE 374
E D+ E E D G+ LGE +EV + M + + DD+D EE E EEEEE
Sbjct: 191 EEEEDEDEDEDEDEAGSELGEGE----EEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEE 246
Query: 375 EAEEEEEEDEEEEEEEEEEEEE 396
E E+ + + E++ EEE++
Sbjct: 247 EGGLRGEKRKRDAEDDGEEEDD 268
Score = 34.7 bits (78), Expect = 0.25
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 5/82 (6%)
Query: 319 DKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEE 378
++ E E+ D + + +E +L E E ++ ++ DE+++++ E EEEE EE
Sbjct: 187 EEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEE 246
Query: 379 E-----EEEDEEEEEEEEEEEE 395
E E+ + E++ EEE++
Sbjct: 247 EGGLRGEKRKRDAEDDGEEEDD 268
>gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32
family, member E isoform 3 [Homo sapiens]
Length = 220
Score = 74.7 bits (182), Expect = 2e-13
Identities = 61/173 (35%), Positives = 95/173 (54%), Gaps = 27/173 (15%)
Query: 250 EKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDA 309
E ++A +L LR++E+ D ++ S G +A+ P L LNLS +IK
Sbjct: 5 ELSSLARLPSLNKLRKLEL---SDNII-SGGLEVLAEKC----PNLTYLNLSGNKIKD-- 54
Query: 310 ALAVAEAMADKAELEKLDL------NGNTLGEEGCEQLQEV--LEGFNMAKVLASLSDDE 361
L+ EA+ + L+ LDL N E E LQ++ L+GF+ A S++E
Sbjct: 55 -LSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEE 113
Query: 362 DEEEEEEGEEEEEEAE--------EEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
D+E+ +E +EEEEE E EEEEE+EEE+E+E+E+E+E + G+GE+
Sbjct: 114 DDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEE 166
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/82 (35%), Positives = 43/82 (52%), Gaps = 4/82 (4%)
Query: 315 EAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEE 374
E D+ E E D G+ LGE +EV + M + + DD+D EE E EEEEE
Sbjct: 143 EEEEDEDEDEDEDEAGSELGEGE----EEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEE 198
Query: 375 EAEEEEEEDEEEEEEEEEEEEE 396
E E+ + + E++ EEE++
Sbjct: 199 EGGLRGEKRKRDAEDDGEEEDD 220
Score = 34.7 bits (78), Expect = 0.25
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 5/82 (6%)
Query: 319 DKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEE 378
++ E E+ D + + +E +L E E ++ ++ DE+++++ E EEEE EE
Sbjct: 139 EEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEE 198
Query: 379 E-----EEEDEEEEEEEEEEEE 395
E E+ + E++ EEE++
Sbjct: 199 EGGLRGEKRKRDAEDDGEEEDD 220
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 72.4 bits (176), Expect = 1e-12
Identities = 62/221 (28%), Positives = 104/221 (47%), Gaps = 17/221 (7%)
Query: 114 LVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKS 173
L ELDLS+N F +G + L+ + L+ L L++ + +L L++
Sbjct: 1524 LEELDLSNNQFDEEGTKALMRALEGK--WMLKRLDLSHLLLNSSTLALLTHRLSQM---- 1577
Query: 174 SAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFA 233
L+ RN + + G L+EA R +LEE+ + N I G+ LA
Sbjct: 1578 ------TCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILP 1631
Query: 234 VNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLP 293
P LR I+L+ N+ + G V +AE+L R++E + G + A+ +A LP
Sbjct: 1632 GLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQE----LP 1687
Query: 294 K-LKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTL 333
+ L+ L+L F + AL++A+A+ LE++ L N L
Sbjct: 1688 QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL 1728
Score = 70.5 bits (171), Expect = 4e-12
Identities = 77/302 (25%), Positives = 133/302 (44%), Gaps = 40/302 (13%)
Query: 51 LEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITA 110
LE L L N E + + +ALE K LKR S + + + ++L ++
Sbjct: 1524 LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLL-------LNSSTLALLTHRLSQ 1576
Query: 111 GAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECH 170
L L L+ N+ G G L+++ +L+EL L++ +G G + LA L
Sbjct: 1577 MTCLQSLRLNRNSIGDVGCCHLSEALRAAT--SLEELDLSHNQIGDAGVQHLATILP--- 1631
Query: 171 RKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQ 230
G P K+ ++G N + + G LAE+ + LEE+ + N + P LAQ
Sbjct: 1632 ------GLPELRKIDLSG-NSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQ 1684
Query: 231 AFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRG 290
+ LRV++L + GA+++A+ L +E I+ + + + G
Sbjct: 1685 ELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAE------------NNLAG 1730
Query: 291 G-------LPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQE 343
G LP L++++L C+I A + + LE + L+ N LG+E +L +
Sbjct: 1731 GVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQ 1790
Query: 344 VL 345
VL
Sbjct: 1791 VL 1792
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/203 (20%), Positives = 88/203 (43%), Gaps = 12/203 (5%)
Query: 147 LKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALA--EAF 204
L+L +C +G ++ + C R ++ ++ N E+D A++L
Sbjct: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQ---------QLSLSQVNLCEDDDASSLLLQSLL 1490
Query: 205 RVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLR 264
+ L+ + + ++ G+ LA L ++L++N F E+G A+ L+
Sbjct: 1491 LSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKW 1550
Query: 265 QVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELE 324
++ ++ L+ S + + + L+ L L+ I ++EA+ LE
Sbjct: 1551 MLKRLDLSHLLLNSSTLALLTHRL-SQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLE 1609
Query: 325 KLDLNGNTLGEEGCEQLQEVLEG 347
+LDL+ N +G+ G + L +L G
Sbjct: 1610 ELDLSHNQIGDAGVQHLATILPG 1632
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 20/182 (10%)
Query: 196 GATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVA 255
G + L +A + L+EV N ++ + + + P LR ++L+ N+ +
Sbjct: 730 GISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLC 789
Query: 256 MAE---TLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE--------------L 298
+A T T+R ++ + S A+ R P L+E L
Sbjct: 790 LARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRA--PDLQESDGQRKGAQSRSLTL 847
Query: 299 NLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLS 358
L C+++ A A+ + + LE++DL+GN L +EGC + E ++A+ L LS
Sbjct: 848 RLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKL-DLS 906
Query: 359 DD 360
D+
Sbjct: 907 DN 908
Score = 43.1 bits (100), Expect = 7e-04
Identities = 48/205 (23%), Positives = 87/205 (42%), Gaps = 24/205 (11%)
Query: 171 RKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQ 230
++ AQ + L L++ + +L+ A AL + LEEV + N + G +A+
Sbjct: 836 QRKGAQSRSLTLRL---QKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAE 892
Query: 231 AFAVNPLLRVINLNDNTFTEKG------AVAMAETLKTLR-----QVEVINFGDCLVRSK 279
A + + R ++L+DN + G AV+ TL L + + F K
Sbjct: 893 AASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQK 952
Query: 280 GA---VAIADAIRGGLPK-----LKELNLSFCEIKRDAALAVAEAMADKAELEKL--DLN 329
G A D++ +P + + L+ C ++ + +A+ L L D +
Sbjct: 953 GPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFS 1012
Query: 330 GNTLGEEGCEQLQEVLEGFNMAKVL 354
GN LG+EG +L ++L G + L
Sbjct: 1013 GNALGDEGAARLAQLLPGLGALQSL 1037
Score = 37.7 bits (86), Expect = 0.030
Identities = 59/243 (24%), Positives = 86/243 (35%), Gaps = 43/243 (17%)
Query: 50 SLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLIT 109
SLE L L N +G + +A L EL++ S + + L E L+
Sbjct: 1607 SLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSG------NSISSAGGVQLAESLVL 1660
Query: 110 AGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTEC 169
+L EL L NA G G L L+ L L +G GG LA AL
Sbjct: 1661 C-RRLEELMLGCNALGDPTALGLAQELPQH----LRVLHLPFSHLGPGGALSLAQAL--- 1712
Query: 170 HRKSSAQGKPLALKVFVAGRN-----------------------RLENDGATALAEAFRV 206
G P ++ +A N +++N A L +F
Sbjct: 1713 ------DGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTS 1766
Query: 207 IGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQV 266
LE + + N + LAQ L+ ++L N T GA +AE L +
Sbjct: 1767 CPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSI 1826
Query: 267 EVI 269
+VI
Sbjct: 1827 QVI 1829
Score = 36.6 bits (83), Expect = 0.066
Identities = 61/250 (24%), Positives = 92/250 (36%), Gaps = 34/250 (13%)
Query: 117 LDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQ 176
L LS+ +F P+ V L S L EL L C +G K LA L S
Sbjct: 1328 LRLSECSFRPEHVSRLATGLSKS--LQLTELTLTQCCLG---QKQLAILL-------SLV 1375
Query: 177 GKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAV-- 234
G+P L R++ A + RV+ LE + I+ Q V
Sbjct: 1376 GRPAGLFSL-----RVQEPWA----DRARVLSLLEVCAQASGSVTEISISETQQQLCVQL 1426
Query: 235 -------NP---LLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAI 284
NP LR+ + + + ET L+Q+ + C ++ +
Sbjct: 1427 EFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLL 1486
Query: 285 ADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEV 344
+ L +LK L+ + + +A + LE+LDL+ N EEG + L
Sbjct: 1487 QSLLLS-LSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRA 1545
Query: 345 LEGFNMAKVL 354
LEG M K L
Sbjct: 1546 LEGKWMLKRL 1555
Score = 33.1 bits (74), Expect = 0.73
Identities = 47/216 (21%), Positives = 92/216 (42%), Gaps = 35/216 (16%)
Query: 37 DAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEI 96
DA+ +I +++ LE + L GN + E R++A+A + ++ SD +
Sbjct: 858 DAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSD-------NGL 910
Query: 97 PPALISLGEGLITAGAQLVELDLS--------------DNAFGPDGVQGF-EALL---KS 138
A + ++A L EL +S + GP F ++L+ S
Sbjct: 911 SVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPS 970
Query: 139 SACFTLQELKLNNCGMGIGGGKILAAALT-ECHRKSSAQGKPLALKVFVAGRNRLENDGA 197
+ + ++L +CG+ + L AL CH L + +G N L ++GA
Sbjct: 971 ELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGH--------LHLDFSG-NALGDEGA 1021
Query: 198 TALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFA 233
LA+ +G L+ +++ +NG++ + L + F+
Sbjct: 1022 ARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFS 1057
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 70.9 bits (172), Expect = 3e-12
Identities = 35/44 (79%), Positives = 37/44 (84%)
Query: 354 LASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEE 397
L LS + EEEEEE +EEEEE EEEEEEDEEEEEEEEEEEEEE
Sbjct: 1061 LLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104
Score = 65.9 bits (159), Expect = 1e-10
Identities = 32/48 (66%), Positives = 38/48 (79%)
Query: 352 KVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQ 399
++L + +EEEEEE EEEEEE EEEEE++EEEEEEEEEEEEE Q
Sbjct: 1060 QLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQ 1107
Score = 63.5 bits (153), Expect = 5e-10
Identities = 32/56 (57%), Positives = 40/56 (71%)
Query: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
S++E+EEE+EE EEEEEE EE+EEE+EEEEEEEEEE + R +S RK
Sbjct: 1069 SEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRK 1124
Score = 61.2 bits (147), Expect = 3e-09
Identities = 29/41 (70%), Positives = 34/41 (82%)
Query: 363 EEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQ 403
E EEE EEE+EE EEEEEE+EE+EEEEEEEEEEE ++ Q
Sbjct: 1067 ESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQ 1107
Score = 61.2 bits (147), Expect = 3e-09
Identities = 28/43 (65%), Positives = 35/43 (81%)
Query: 356 SLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEP 398
S ++E+EE+EEE EEEEEE E+EEEE+EEEEEEEEE + P
Sbjct: 1068 SSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSP 1110
Score = 60.1 bits (144), Expect = 6e-09
Identities = 28/50 (56%), Positives = 37/50 (74%)
Query: 363 EEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSR 412
E +E EEEEEE +EEEEE+EEEEEE+EEEEEEE ++ + ++P R
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPR 1112
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/45 (60%), Positives = 36/45 (80%)
Query: 355 ASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQ 399
+S ++E+E+EEEE EEEEEE +EEEEE+EEEEEEEE + P+
Sbjct: 1068 SSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPR 1112
Score = 57.8 bits (138), Expect = 3e-08
Identities = 27/56 (48%), Positives = 38/56 (67%)
Query: 364 EEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT 419
E +E EEEEE E+EEEE+EEEEEEE+EEEEEE ++ + E + ++ P +
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQS 1118
Score = 57.8 bits (138), Expect = 3e-08
Identities = 27/40 (67%), Positives = 33/40 (82%)
Query: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQ 400
E +E E EEEEE+ EEEEEE+EEEE+EEEEEEEEE ++
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEE 1102
Score = 55.8 bits (133), Expect = 1e-07
Identities = 26/41 (63%), Positives = 34/41 (82%)
Query: 350 MAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEE 390
++K + ++E++EEEEE EEEEEE EEEEEE+EEEEEEE
Sbjct: 1064 LSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104
Score = 50.8 bits (120), Expect = 3e-06
Identities = 25/54 (46%), Positives = 34/54 (62%)
Query: 372 EEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPV 425
+E EEEEEEDEEEEEEEEEEEE+E ++ + E+ + + P +P V
Sbjct: 1066 KESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSV 1119
Score = 48.9 bits (115), Expect = 1e-05
Identities = 29/59 (49%), Positives = 36/59 (61%), Gaps = 9/59 (15%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEE---------EEEEEEEEEEPQQRGQGEKSA 408
DD + EEEE EEEEEE EEEEEE EEEE + + +E+EEP+ + E SA
Sbjct: 1345 DDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSA 1403
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/57 (49%), Positives = 34/57 (59%)
Query: 351 AKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKS 407
A V + S E E++ EEEEE EEEEEE+EEEEE EEEE ++ G KS
Sbjct: 1331 APVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKS 1387
Score = 47.0 bits (110), Expect = 5e-05
Identities = 28/66 (42%), Positives = 37/66 (56%), Gaps = 10/66 (15%)
Query: 355 ASLSDDEDEEEE---------EEGEEEEEEA-EEEEEEDEEEEEEEEEEEEEEPQQRGQG 404
A L +E+ EE GE+ E++ + EEEE+EEEEEEEEEEEEE ++ G G
Sbjct: 1317 ALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGG 1376
Query: 405 EKSATP 410
P
Sbjct: 1377 NVEKDP 1382
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/64 (40%), Positives = 34/64 (53%), Gaps = 9/64 (14%)
Query: 367 EEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVL 426
E G+ E E EEE+EEE+EEEEEEEEEE + + E+ + E +
Sbjct: 1057 ERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEE---------EEEEEEEENIQ 1107
Query: 427 SSPP 430
SSPP
Sbjct: 1108 SSPP 1111
Score = 43.5 bits (101), Expect = 5e-04
Identities = 29/66 (43%), Positives = 34/66 (51%), Gaps = 28/66 (42%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEE--------------EEDEEEE--------------EEE 390
++E+EEEEEE EEEEEE EEEE +E EE E EEE
Sbjct: 1352 EEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEE 1411
Query: 391 EEEEEE 396
EEE+EE
Sbjct: 1412 EEEDEE 1417
Score = 40.0 bits (92), Expect = 0.006
Identities = 22/67 (32%), Positives = 32/67 (47%)
Query: 363 EEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEP 422
E GE + +E +EEEEEE+EEEEEEE ++ E+ + + N
Sbjct: 1050 ESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSS 1109
Query: 423 APVLSSP 429
P L+ P
Sbjct: 1110 PPRLTKP 1116
Score = 40.0 bits (92), Expect = 0.006
Identities = 17/42 (40%), Positives = 26/42 (61%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQ 400
DD +EEEEE+ E E + ++ED+ E E E+EE P++
Sbjct: 1406 DDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRE 1447
Score = 38.1 bits (87), Expect = 0.023
Identities = 17/41 (41%), Positives = 25/41 (60%)
Query: 355 ASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEE 395
A L D E+EEEE+E E+ + ++E+D E E E+EE
Sbjct: 1403 ARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEE 1443
Score = 37.7 bits (86), Expect = 0.030
Identities = 26/60 (43%), Positives = 33/60 (55%), Gaps = 21/60 (35%)
Query: 359 DDEDEEEEEEGEEEE--------------EEAEEEEEEDEEE------EEEEEEEEEEEP 398
++E+EEEE EGEEEE +E EE E E+E + EEEEEE+EEP
Sbjct: 1360 EEEEEEEE-EGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEP 1418
Score = 37.4 bits (85), Expect = 0.039
Identities = 19/58 (32%), Positives = 29/58 (50%)
Query: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPN 418
+D EEEEE +EE E+ + +DE++ E E E+E R ++ LD N
Sbjct: 1406 DDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLN 1463
Score = 33.9 bits (76), Expect = 0.43
Identities = 25/119 (21%), Positives = 55/119 (46%), Gaps = 1/119 (0%)
Query: 299 NLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGF-NMAKVLASL 357
N S E D + E ++ E E+ + EEG +++ +G + K +
Sbjct: 1336 NTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEI 1395
Query: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILD 416
S ++++ + EEEEE +EE +E+ + ++E++ E + + E +++L+
Sbjct: 1396 STEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLE 1454
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 67.0 bits (162), Expect = 5e-11
Identities = 51/136 (37%), Positives = 67/136 (49%), Gaps = 17/136 (12%)
Query: 332 TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEE--EEE 389
T G G L+E L N+ ++E+EEEEEE EEEEEE EEEEEDEEE EEE
Sbjct: 865 TPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEE 924
Query: 390 EEEEE-------------EEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVST 436
EEEEE EEE ++ + E+ + L+ T +PPP +
Sbjct: 925 EEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPP 984
Query: 437 FLAFPSPEKLLRLGPK 452
A P PE ++ P+
Sbjct: 985 --ALPPPESPPKVQPE 998
Score = 64.3 bits (155), Expect = 3e-10
Identities = 47/127 (37%), Positives = 65/127 (51%), Gaps = 5/127 (3%)
Query: 328 LNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEE--EEGEEEEEEAEEEEEEDE- 384
+N N+ EE E+ +E E + ++E++EEE EE EEEEEE EEE EE+E
Sbjct: 881 ININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEG 940
Query: 385 --EEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPS 442
EEEEEEE+EEEEE + + + T ++ + P + PPP P
Sbjct: 941 ELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPE 1000
Query: 443 PEKLLRL 449
PE L L
Sbjct: 1001 PEPGLLL 1007
Score = 30.0 bits (66), Expect = 6.2
Identities = 39/175 (22%), Positives = 70/175 (40%), Gaps = 20/175 (11%)
Query: 315 EAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEE 374
E ++ + E+ + + EE E+ +E E F + ++E++EEEEE EE E
Sbjct: 902 EEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVE 961
Query: 375 EAEEEEEEDEEEEEEEE--------EEEEEEPQQRGQGEKSATPSRKILDPNTGE----- 421
+ E E EE E P+ + + E ++ +P T E
Sbjct: 962 DLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD 1021
Query: 422 PAPVLSS---PPPADV----STFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKV 469
AP L+ P +V + A P P++L+ P + + ++ +KV
Sbjct: 1022 TAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKV 1076
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/247 (23%), Positives = 109/247 (44%), Gaps = 40/247 (16%)
Query: 108 ITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALT 167
+ + + +L+L DN +GV +L+ + + LQE+ ++N +G+ G +I++
Sbjct: 129 LVSNMAVTKLELEDNCIMEEGVLSLVEMLQEN--YYLQEMNISNNHLGLEGARIIS---- 182
Query: 168 ECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITA 227
+ ++S+ L L N + D A L +A ++++ + N + G
Sbjct: 183 DFFERNSSSIWSLELS-----GNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEH 237
Query: 228 LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADA 287
L Q A+N L ++L+ N F ++GAVA+ +
Sbjct: 238 LGQMLAINVGLTSLDLSWNNF----------------------------HTRGAVALCNG 269
Query: 288 IRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEG 347
+RG + L +L+LS + ALA+ E + L LD+ GN +G EG ++ + LE
Sbjct: 270 LRGNVT-LTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLES 328
Query: 348 FNMAKVL 354
+VL
Sbjct: 329 NESLRVL 335
Score = 59.7 bits (143), Expect = 7e-09
Identities = 38/141 (26%), Positives = 72/141 (51%), Gaps = 2/141 (1%)
Query: 207 IGTLEE--VHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLR 264
I +EE V++ +G+ G A+A A N + + L DN E+G +++ E L+
Sbjct: 102 IRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENY 161
Query: 265 QVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELE 324
++ +N + + +GA I+D + L LS + K D+A + +A++ +++
Sbjct: 162 YLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIK 221
Query: 325 KLDLNGNTLGEEGCEQLQEVL 345
KLDL+ N + G E L ++L
Sbjct: 222 KLDLSHNQFSDVGGEHLGQML 242
Score = 51.2 bits (121), Expect = 3e-06
Identities = 53/226 (23%), Positives = 96/226 (42%), Gaps = 18/226 (7%)
Query: 36 EDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTE 95
E +++ +++ L+ + + N +G+E AR+I+ E+ S WS +G E
Sbjct: 148 EGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSS---SIWSLELSGNDFKE 204
Query: 96 IPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMG 155
AL+ ++ Q+ +LDLS N F G + +L + T +L NN
Sbjct: 205 DSAALLCQA---LSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFH-- 259
Query: 156 IGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHM 215
A+ C + +G K+ ++ N N+ A AL E R+ L + +
Sbjct: 260 ------TRGAVALC---NGLRGNVTLTKLDLS-MNGFGNEVALALGEVLRLNRCLVYLDI 309
Query: 216 PQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLK 261
N I + G + +++ N LRV+ L N GA+ + +K
Sbjct: 310 GGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIK 355
>gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]
Length = 185
Score = 65.5 bits (158), Expect = 1e-10
Identities = 30/47 (63%), Positives = 40/47 (85%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
+E+E EEEE E EEEE EEE+EEDEEEEE+EEE+EE+E ++ +G+K
Sbjct: 119 EEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKK 165
Score = 63.2 bits (152), Expect = 7e-10
Identities = 28/47 (59%), Positives = 41/47 (87%)
Query: 357 LSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQ 403
+ ++E EEEEEE EEEE+E E+EE+E+EEE+EEE+EE+EEE ++ G+
Sbjct: 118 VEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGK 164
Score = 60.1 bits (144), Expect = 6e-09
Identities = 28/46 (60%), Positives = 38/46 (82%)
Query: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
E+EEEE E EE+EEE EE+EEE+E+EEE+EE+EEEEE + + E+
Sbjct: 124 EEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEE 169
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/47 (57%), Positives = 40/47 (85%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
+E+EEE EE E+EEE+ E+EEEE++EEE+EE+EEEEE+ ++ + EK
Sbjct: 124 EEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEK 170
Score = 57.4 bits (137), Expect = 4e-08
Identities = 27/53 (50%), Positives = 38/53 (71%)
Query: 362 DEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKI 414
+EEE EE EEE EE E+EEE++E+EEEEE+EEE+EE ++ + E K+
Sbjct: 119 EEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKV 171
Score = 57.0 bits (136), Expect = 5e-08
Identities = 37/93 (39%), Positives = 52/93 (55%), Gaps = 22/93 (23%)
Query: 305 IKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEE 364
+ R AAL E A + G + EE E+ +E +E +E++E
Sbjct: 99 VARTAALVAEECSAQQ---------GLPVEEEEVEEEEEEVE-------------EEEKE 136
Query: 365 EEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEE 397
EE+E +EEEEE EEE+EEDEEEEE+E ++ EEE
Sbjct: 137 EEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEE 169
Score = 54.3 bits (129), Expect = 3e-07
Identities = 24/48 (50%), Positives = 39/48 (81%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
++E+ EEEE+ EE+EE+ EEEE+E+E+EE+EEEEE+E + + + E+
Sbjct: 126 EEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEE 173
Score = 53.5 bits (127), Expect = 5e-07
Identities = 25/51 (49%), Positives = 40/51 (78%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSAT 409
++E EEEE+E E+EE+E EEE+EE++EE+EEEEE+E ++ ++ E+ T
Sbjct: 127 EEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEEEIDT 177
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/57 (49%), Positives = 38/57 (66%), Gaps = 2/57 (3%)
Query: 365 EEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGE 421
EEEE EEEEEE EEEE+E EE+EE+EEEEE+E ++ E+ +K+ + E
Sbjct: 119 EEEEVEEEEEEVEEEEKE--EEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEE 173
Score = 48.9 bits (115), Expect = 1e-05
Identities = 24/57 (42%), Positives = 40/57 (70%)
Query: 349 NMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGE 405
++A+ A ++++ ++ EEEE E EEEE E+EE+EEE+EE+EEEE ++ + E
Sbjct: 98 SVARTAALVAEECSAQQGLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEE 154
Score = 47.8 bits (112), Expect = 3e-05
Identities = 25/59 (42%), Positives = 37/59 (62%)
Query: 355 ASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
A+L +E ++ EEEE EEEEE +EEE+EEE+EE+EEE ++ + E+ K
Sbjct: 103 AALVAEECSAQQGLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEK 161
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 65.1 bits (157), Expect = 2e-10
Identities = 42/104 (40%), Positives = 57/104 (54%), Gaps = 3/104 (2%)
Query: 303 CEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEV-LEGFNMAKVLASLSDDE 361
CE + +A D+ E+ D G G EG + QE+ E AK +D
Sbjct: 794 CEDENEAEGKGDNEGEDEGEIHAED--GEMKGNEGETESQELSAENHGEAKNDEKGVEDG 851
Query: 362 DEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGE 405
+ + EEEEEE EE+EEE+EEEE+EEEEEEEEE +++G E
Sbjct: 852 GGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 53.5 bits (127), Expect = 5e-07
Identities = 32/87 (36%), Positives = 50/87 (57%), Gaps = 1/87 (1%)
Query: 315 EAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEE 374
E ++ E E +L+ GE ++ + V +G + ++E+EE+EEE EEEE+
Sbjct: 820 EMKGNEGETESQELSAENHGEAKNDE-KGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQ 878
Query: 375 EAEEEEEEDEEEEEEEEEEEEEEPQQR 401
E EEEEEE+EEE+ EE + P+ R
Sbjct: 879 EEEEEEEEEEEEKGNEEPLSLDWPETR 905
Score = 43.9 bits (102), Expect = 4e-04
Identities = 22/41 (53%), Positives = 27/41 (65%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQ 399
+ E+EEEEEE EEEEEE EEEEE+ EE + E + Q
Sbjct: 868 EQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQ 908
Score = 35.4 bits (80), Expect = 0.15
Identities = 34/105 (32%), Positives = 47/105 (44%), Gaps = 12/105 (11%)
Query: 319 DKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEG--EEEEEEA 376
D AE E G GEEG + EG K + + E E +G EE E+E
Sbjct: 746 DVAEAES---TGEMPGEEG----ETAGEGETEEKSGGETQPEGEGETETQGKGEECEDEN 798
Query: 377 EEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGE 421
E E + D E E+E E E+ + +GE T S+++ N GE
Sbjct: 799 EAEGKGDNEGEDEGEIHAEDGEMKGNEGE---TESQELSAENHGE 840
Score = 35.4 bits (80), Expect = 0.15
Identities = 18/68 (26%), Positives = 32/68 (47%)
Query: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDP 417
S + E E + +E+ E+ D + EEEEEEEEE+ ++ + E+ + +
Sbjct: 830 SQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEE 889
Query: 418 NTGEPAPV 425
G P+
Sbjct: 890 EKGNEEPL 897
Score = 32.3 bits (72), Expect = 1.2
Identities = 51/212 (24%), Positives = 83/212 (39%), Gaps = 28/212 (13%)
Query: 236 PLLRVINLNDNTFTEKGAVAMAETL--KTLRQVEVINFGDC---LVRSKGAVAIADAIRG 290
P+ +V+ L D + GA+A+ E K L+ ++ G L S I +
Sbjct: 618 PVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLH 677
Query: 291 GLPKLKELNL-------SFCEIKRDAALAVAEAMADKAELEKL-----------DLNGNT 332
L L+E+ L S + R A AE+ ++ E KL D+ G+
Sbjct: 678 SLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQ 737
Query: 333 LGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEE---GEEEEEEAEEEEEEDEEEEEE 389
G ++ +V E + ++ + E E EE GE + E E E + + EE E
Sbjct: 738 KENPGGQE--DVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECE 795
Query: 390 EEEEEEEEPQQRGQGEKSATPSRKILDPNTGE 421
+E E E + G+ E + N GE
Sbjct: 796 DENEAEGKGDNEGEDEGEIHAEDGEMKGNEGE 827
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 64.7 bits (156), Expect = 2e-10
Identities = 78/315 (24%), Positives = 125/315 (39%), Gaps = 48/315 (15%)
Query: 34 TAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLR 93
T+ + + + SL L L N++G RV+ + L+ C+ ++ GR
Sbjct: 726 TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPG----CNIRRLWLGRCG 781
Query: 94 TEIPPAL-ISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNC 152
ISL ++++ +LVELDLSDNA G G++ LK C L++L L +C
Sbjct: 782 LSHECCFDISL---VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLC-NLKKLWLVSC 837
Query: 153 GMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAE-AFRVIGTLE 211
+ + LA+ L+ H +L G N L + G L E A L+
Sbjct: 838 CLTSACCQDLASVLSTSH----------SLTRLYVGENALGDSGVAILCEKAKNPQCNLQ 887
Query: 212 EVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINF 271
++ + +G+ +AL+ + N L + L NT +KG + E L
Sbjct: 888 KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL---------H 938
Query: 272 GDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN 331
DC KL+ L L C + ++ + L KL L N
Sbjct: 939 PDC-------------------KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
Query: 332 TLGEEGCEQLQEVLE 346
LG+ G EVL+
Sbjct: 980 DLGDLGVMMFCEVLK 994
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 64.7 bits (156), Expect = 2e-10
Identities = 78/315 (24%), Positives = 125/315 (39%), Gaps = 48/315 (15%)
Query: 34 TAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLR 93
T+ + + + SL L L N++G RV+ + L+ C+ ++ GR
Sbjct: 726 TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPG----CNIRRLWLGRCG 781
Query: 94 TEIPPAL-ISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNC 152
ISL ++++ +LVELDLSDNA G G++ LK C L++L L +C
Sbjct: 782 LSHECCFDISL---VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLC-NLKKLWLVSC 837
Query: 153 GMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAE-AFRVIGTLE 211
+ + LA+ L+ H +L G N L + G L E A L+
Sbjct: 838 CLTSACCQDLASVLSTSH----------SLTRLYVGENALGDSGVAILCEKAKNPQCNLQ 887
Query: 212 EVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINF 271
++ + +G+ +AL+ + N L + L NT +KG + E L
Sbjct: 888 KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL---------H 938
Query: 272 GDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN 331
DC KL+ L L C + ++ + L KL L N
Sbjct: 939 PDC-------------------KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
Query: 332 TLGEEGCEQLQEVLE 346
LG+ G EVL+
Sbjct: 980 DLGDLGVMMFCEVLK 994
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 63.9 bits (154), Expect = 4e-10
Identities = 37/81 (45%), Positives = 46/81 (56%), Gaps = 11/81 (13%)
Query: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEE-----------EEEEEEEEEPQQRGQGEK 406
+DDED+EE +E EEEEEE EEEE D EEEE +EEE+EEEE G+K
Sbjct: 435 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 494
Query: 407 SATPSRKILDPNTGEPAPVLS 427
S S +I + EP +S
Sbjct: 495 SPMSSLQISNEKNLEPGKQIS 515
Score = 31.6 bits (70), Expect = 2.1
Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 46/241 (19%)
Query: 200 LAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAET 259
L + + G + E +P G +P + + P +TF + G V A
Sbjct: 242 LKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKP-------GPDTFPDYGDVLRAVE 294
Query: 260 LKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE---LNLSF---CEIKRDAALAV 313
R + G L R + + DA R +L+E L+L + C + D V
Sbjct: 295 KAAARH----SLG--LPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 348
Query: 314 AEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKV----------------LASL 357
A++D +L N + +L EV+ + M + +S
Sbjct: 349 DPALSDPVLARRLRENRSL----AMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSH 404
Query: 358 SDDEDEEEEEEGEEEEEEAEE-----EEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSR 412
S D E + GE A + E ++E++EE +EEEEE ++ + E+ AT S
Sbjct: 405 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEE--EEEEEATDSE 462
Query: 413 K 413
+
Sbjct: 463 E 463
Score = 30.0 bits (66), Expect = 6.2
Identities = 40/169 (23%), Positives = 68/169 (40%), Gaps = 18/169 (10%)
Query: 312 AVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEE--- 368
+ + A D + E+ D EE E+ + E ++ ++ DDE+E+EEEE
Sbjct: 429 SASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAA 488
Query: 369 ---GEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT------ 419
G++ + + E E ++ E Q +G+ + S + L P++
Sbjct: 489 GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESN 548
Query: 420 GEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEK 468
GE L+ + VS F + L L SSV +TD S K
Sbjct: 549 GEQPEELTLEEESPVSQL--FELEIEALPLDTPSSV----ETDISSSRK 591
>gi|215422388 death-domain associated protein isoform a [Homo
sapiens]
Length = 740
Score = 63.9 bits (154), Expect = 4e-10
Identities = 37/81 (45%), Positives = 46/81 (56%), Gaps = 11/81 (13%)
Query: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEE-----------EEEEEEEEEPQQRGQGEK 406
+DDED+EE +E EEEEEE EEEE D EEEE +EEE+EEEE G+K
Sbjct: 435 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 494
Query: 407 SATPSRKILDPNTGEPAPVLS 427
S S +I + EP +S
Sbjct: 495 SPMSSLQISNEKNLEPGKQIS 515
Score = 31.6 bits (70), Expect = 2.1
Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 46/241 (19%)
Query: 200 LAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAET 259
L + + G + E +P G +P + + P +TF + G V A
Sbjct: 242 LKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKP-------GPDTFPDYGDVLRAVE 294
Query: 260 LKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE---LNLSF---CEIKRDAALAV 313
R + G L R + + DA R +L+E L+L + C + D V
Sbjct: 295 KAAARH----SLG--LPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 348
Query: 314 AEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKV----------------LASL 357
A++D +L N + +L EV+ + M + +S
Sbjct: 349 DPALSDPVLARRLRENRSL----AMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSH 404
Query: 358 SDDEDEEEEEEGEEEEEEAEE-----EEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSR 412
S D E + GE A + E ++E++EE +EEEEE ++ + E+ AT S
Sbjct: 405 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEE--EEEEEATDSE 462
Query: 413 K 413
+
Sbjct: 463 E 463
Score = 30.0 bits (66), Expect = 6.2
Identities = 40/169 (23%), Positives = 68/169 (40%), Gaps = 18/169 (10%)
Query: 312 AVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEE--- 368
+ + A D + E+ D EE E+ + E ++ ++ DDE+E+EEEE
Sbjct: 429 SASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAA 488
Query: 369 ---GEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT------ 419
G++ + + E E ++ E Q +G+ + S + L P++
Sbjct: 489 GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESN 548
Query: 420 GEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEK 468
GE L+ + VS F + L L SSV +TD S K
Sbjct: 549 GEQPEELTLEEESPVSQL--FELEIEALPLDTPSSV----ETDISSSRK 591
>gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
Length = 752
Score = 63.9 bits (154), Expect = 4e-10
Identities = 37/81 (45%), Positives = 46/81 (56%), Gaps = 11/81 (13%)
Query: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEE-----------EEEEEEEEEPQQRGQGEK 406
+DDED+EE +E EEEEEE EEEE D EEEE +EEE+EEEE G+K
Sbjct: 447 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506
Query: 407 SATPSRKILDPNTGEPAPVLS 427
S S +I + EP +S
Sbjct: 507 SPMSSLQISNEKNLEPGKQIS 527
Score = 31.6 bits (70), Expect = 2.1
Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 46/241 (19%)
Query: 200 LAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAET 259
L + + G + E +P G +P + + P +TF + G V A
Sbjct: 254 LKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKP-------GPDTFPDYGDVLRAVE 306
Query: 260 LKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE---LNLSF---CEIKRDAALAV 313
R + G L R + + DA R +L+E L+L + C + D V
Sbjct: 307 KAAARH----SLG--LPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 360
Query: 314 AEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKV----------------LASL 357
A++D +L N + +L EV+ + M + +S
Sbjct: 361 DPALSDPVLARRLRENRSL----AMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSH 416
Query: 358 SDDEDEEEEEEGEEEEEEAEE-----EEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSR 412
S D E + GE A + E ++E++EE +EEEEE ++ + E+ AT S
Sbjct: 417 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEE--EEEEEATDSE 474
Query: 413 K 413
+
Sbjct: 475 E 475
Score = 30.0 bits (66), Expect = 6.2
Identities = 40/169 (23%), Positives = 68/169 (40%), Gaps = 18/169 (10%)
Query: 312 AVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEE--- 368
+ + A D + E+ D EE E+ + E ++ ++ DDE+E+EEEE
Sbjct: 441 SASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAA 500
Query: 369 ---GEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT------ 419
G++ + + E E ++ E Q +G+ + S + L P++
Sbjct: 501 GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESN 560
Query: 420 GEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEK 468
GE L+ + VS F + L L SSV +TD S K
Sbjct: 561 GEQPEELTLEEESPVSQL--FELEIEALPLDTPSSV----ETDISSSRK 603
>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member B [Homo sapiens]
Length = 251
Score = 63.9 bits (154), Expect = 4e-10
Identities = 53/197 (26%), Positives = 100/197 (50%), Gaps = 23/197 (11%)
Query: 210 LEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVI 269
L+++ + +N I G+ LA+ P L +NL+ N + ++ E LK L ++ +
Sbjct: 66 LKKLELSENRI-FGGLDMLAEKL---PNLTHLNLSGNKLKD---ISTLEPLKKLECLKSL 118
Query: 270 NFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLN 329
+ +C V + +++ LP+L L+ + D ++A D + E+ D
Sbjct: 119 DLFNCEVTNLNDYR--ESVFKLLPQLTYLD---GYDREDQEAPDSDAEVDGVDEEEEDEE 173
Query: 330 GNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEE 389
G +E E +E +++DE+E+ EG+E+++E EEEEE +EE+
Sbjct: 174 GEDEEDEDDEDGEE-----------EEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEED 222
Query: 390 EEEEEEEEPQQRGQGEK 406
E+E+E+EE ++ G+GEK
Sbjct: 223 EDEDEDEEEEEGGKGEK 239
>gi|211904182 DDB1 and CUL4 associated factor 8-like 2 [Homo
sapiens]
Length = 631
Score = 63.5 bits (153), Expect = 5e-10
Identities = 32/51 (62%), Positives = 38/51 (74%)
Query: 354 LASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQG 404
L + E EEE+EE +EE E EEEEEE+EEEEEEEEEEEEE+P+ QG
Sbjct: 105 LVGEEETEREEEDEEIQEEGGEEEEEEEEEEEEEEEEEEEEEEQPRAGPQG 155
Score = 63.2 bits (152), Expect = 7e-10
Identities = 30/44 (68%), Positives = 35/44 (79%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRG 402
++EDEE +EEG EEEEE EEEEEE+EEEEEEEEE+ PQ G
Sbjct: 114 EEEDEEIQEEGGEEEEEEEEEEEEEEEEEEEEEEQPRAGPQGSG 157
Score = 62.4 bits (150), Expect = 1e-09
Identities = 31/52 (59%), Positives = 38/52 (73%)
Query: 357 LSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSA 408
L +E+ E EEE EE +EE EEEEE+EEEEEEEEEEEEEE +Q G + +
Sbjct: 105 LVGEEETEREEEDEEIQEEGGEEEEEEEEEEEEEEEEEEEEEEQPRAGPQGS 156
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/47 (59%), Positives = 34/47 (72%), Gaps = 1/47 (2%)
Query: 364 EEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATP 410
EEE E EEE+EE +EE E EEEEEEEEEEEEEE ++ + + A P
Sbjct: 108 EEETEREEEDEEIQEEGGE-EEEEEEEEEEEEEEEEEEEEEQPRAGP 153
Score = 45.8 bits (107), Expect = 1e-04
Identities = 23/44 (52%), Positives = 28/44 (63%)
Query: 369 GEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSR 412
GEEE E EE+EE EE EEEEEEEEEE ++ + E+ R
Sbjct: 107 GEEETEREEEDEEIQEEGGEEEEEEEEEEEEEEEEEEEEEEQPR 150
Score = 38.9 bits (89), Expect = 0.013
Identities = 43/145 (29%), Positives = 62/145 (42%), Gaps = 30/145 (20%)
Query: 291 GLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGF-N 349
GLP L +L ++ A+A EA +D ++ +L+ G+ G + GF N
Sbjct: 10 GLPDLGTESLFSSPEEQSGAVAATEASSD-IDIATSELSVTVTGD-GSDSRDG---GFPN 64
Query: 350 MAKVLASLSDDEDEEEEEEGEEEEE-----------------EAEEEEEEDEEE------ 386
A SD E E+ E E E+ EE E E+E+E
Sbjct: 65 DASTENRSSDQESASEDIELESLEDFEHFLMSGESLFHYPLVGEEETEREEEDEEIQEEG 124
Query: 387 -EEEEEEEEEEEPQQRGQGEKSATP 410
EEEEEEEEEEE ++ + E+ P
Sbjct: 125 GEEEEEEEEEEEEEEEEEEEEEEQP 149
>gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32
family, member E isoform 2 [Homo sapiens]
Length = 227
Score = 63.5 bits (153), Expect = 5e-10
Identities = 48/156 (30%), Positives = 78/156 (50%), Gaps = 33/156 (21%)
Query: 262 TLRQVEVINFGDCLVRSKGAVAIADAIRG-GLPKLKELNLSFCEIKRDAALAVAEAMADK 320
T +++E ++ + + S + + +R L LK L+L CEI
Sbjct: 40 TFKELEFLSMANVELSSLARLPSLNKLRKQNLKNLKSLDLFNCEIT-------------- 85
Query: 321 AELEKLDLNGNTLGEEGCEQLQEV--LEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAE- 377
N E E LQ++ L+GF+ A S++ED+E+ +E +EEEEE E
Sbjct: 86 --------NLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEENEA 137
Query: 378 -------EEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
EEEEE+EEE+E+E+E+E+E + G+GE+
Sbjct: 138 GPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEE 173
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/82 (35%), Positives = 43/82 (52%), Gaps = 4/82 (4%)
Query: 315 EAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEE 374
E D+ E E D G+ LGE +EV + M + + DD+D EE E EEEEE
Sbjct: 150 EEEEDEDEDEDEDEAGSELGEGE----EEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEE 205
Query: 375 EAEEEEEEDEEEEEEEEEEEEE 396
E E+ + + E++ EEE++
Sbjct: 206 EGGLRGEKRKRDAEDDGEEEDD 227
Score = 36.2 bits (82), Expect = 0.086
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 370 EEEEEEAEEEEEEDEEE--EEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGE 421
++E+ EA + EEED+E+ E++EEEEE E G E+ + D + E
Sbjct: 108 DQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDE 161
Score = 34.7 bits (78), Expect = 0.25
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 5/82 (6%)
Query: 319 DKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEE 378
++ E E+ D + + +E +L E E ++ ++ DE+++++ E EEEE EE
Sbjct: 146 EEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEE 205
Query: 379 E-----EEEDEEEEEEEEEEEE 395
E E+ + E++ EEE++
Sbjct: 206 EGGLRGEKRKRDAEDDGEEEDD 227
>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 63.2 bits (152), Expect = 7e-10
Identities = 68/265 (25%), Positives = 105/265 (39%), Gaps = 40/265 (15%)
Query: 218 NGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVR 277
N + H G+ L L +NL N +G + L + R V + +
Sbjct: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
Query: 278 SKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN------ 331
+GAVA+A+ I P+L L+L EIK +A++ A+ L +LDL+
Sbjct: 388 CEGAVAVAEFIAES-PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAV 446
Query: 332 -TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDE------ 384
+ E L E+ G VLA +++++ + E A E + +DE
Sbjct: 447 KSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQ 506
Query: 385 --------------EEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPP 430
+ + + EEEEEEE GE+ TPS I +TG P PP
Sbjct: 507 NGAPSPAPSPDSDSDSDSDGEEEEEEE------GERDETPSGAIDTRDTGSSEP---QPP 557
Query: 431 PADVSTFLAFPS---PEKLLRLGPK 452
P + P+ PE L L P+
Sbjct: 558 PEPPRSGPPLPNGLKPEFALALPPE 582
Score = 53.1 bits (126), Expect = 7e-07
Identities = 90/388 (23%), Positives = 151/388 (38%), Gaps = 48/388 (12%)
Query: 65 AARVIAKALEKKSELKRCHWSDM-FTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNA 123
+A +A+AL +S L H + +GR P L++ + L EL L+DN
Sbjct: 220 SAPFVARALRIRSSLAVLHLENASLSGR-----PLMLLATA---LKMNMNLRELYLADNK 271
Query: 124 FGPDGVQGFEAL--LKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLA 181
+G+Q L L C +LQ L L N + G + L E +
Sbjct: 272 L--NGLQDSAQLGNLLKFNC-SLQILDLRNNHVLDSGLAYICEGLKEQRK---------G 319
Query: 182 LKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVI 241
L V N+L + G L +LE +++ N I + G+ L N + +
Sbjct: 320 LVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRL 379
Query: 242 NLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKL------ 295
L T +GAVA+AE + ++ ++ + +++ G +A++ A++ L
Sbjct: 380 GLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDR 439
Query: 296 ---KELNLSFCEIKRDAA----------LAVAEAMADKAELEKLDLNGNTLGEEGCEQLQ 342
KE SF E ++ L +A +K + +L + +
Sbjct: 440 EPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDD 499
Query: 343 EVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRG 402
E G + S D D + + +GEEEEEE E E +E + + EPQ
Sbjct: 500 EPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEE-EGERDETPSGAIDTRDTGSSEPQPPP 558
Query: 403 QGEKSATPSRKILDPNTGEPAPVLSSPP 430
+ +S P PN +P L+ PP
Sbjct: 559 EPPRSGPPL-----PNGLKPEFALALPP 581
Score = 39.3 bits (90), Expect = 0.010
Identities = 37/169 (21%), Positives = 68/169 (40%), Gaps = 1/169 (0%)
Query: 178 KPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPL 237
K L+ A L + A +A A R+ +L +H+ ++ + LA A +N
Sbjct: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMN 261
Query: 238 LRVINLNDNTFTE-KGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLK 296
LR + L DN + + + LK +++++ + V G I + ++ L
Sbjct: 262 LRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLV 321
Query: 297 ELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVL 345
L L ++ + + LE L+L N +G EG L+ L
Sbjct: 322 TLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL 370
>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 63.2 bits (152), Expect = 7e-10
Identities = 68/265 (25%), Positives = 105/265 (39%), Gaps = 40/265 (15%)
Query: 218 NGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVR 277
N + H G+ L L +NL N +G + L + R V + +
Sbjct: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
Query: 278 SKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN------ 331
+GAVA+A+ I P+L L+L EIK +A++ A+ L +LDL+
Sbjct: 388 CEGAVAVAEFIAES-PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAV 446
Query: 332 -TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDE------ 384
+ E L E+ G VLA +++++ + E A E + +DE
Sbjct: 447 KSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQ 506
Query: 385 --------------EEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPP 430
+ + + EEEEEEE GE+ TPS I +TG P PP
Sbjct: 507 NGAPSPAPSPDSDSDSDSDGEEEEEEE------GERDETPSGAIDTRDTGSSEP---QPP 557
Query: 431 PADVSTFLAFPS---PEKLLRLGPK 452
P + P+ PE L L P+
Sbjct: 558 PEPPRSGPPLPNGLKPEFALALPPE 582
Score = 53.1 bits (126), Expect = 7e-07
Identities = 90/388 (23%), Positives = 151/388 (38%), Gaps = 48/388 (12%)
Query: 65 AARVIAKALEKKSELKRCHWSDM-FTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNA 123
+A +A+AL +S L H + +GR P L++ + L EL L+DN
Sbjct: 220 SAPFVARALRIRSSLAVLHLENASLSGR-----PLMLLATA---LKMNMNLRELYLADNK 271
Query: 124 FGPDGVQGFEAL--LKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLA 181
+G+Q L L C +LQ L L N + G + L E +
Sbjct: 272 L--NGLQDSAQLGNLLKFNC-SLQILDLRNNHVLDSGLAYICEGLKEQRK---------G 319
Query: 182 LKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVI 241
L V N+L + G L +LE +++ N I + G+ L N + +
Sbjct: 320 LVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRL 379
Query: 242 NLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKL------ 295
L T +GAVA+AE + ++ ++ + +++ G +A++ A++ L
Sbjct: 380 GLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDR 439
Query: 296 ---KELNLSFCEIKRDAA----------LAVAEAMADKAELEKLDLNGNTLGEEGCEQLQ 342
KE SF E ++ L +A +K + +L + +
Sbjct: 440 EPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDD 499
Query: 343 EVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRG 402
E G + S D D + + +GEEEEEE E E +E + + EPQ
Sbjct: 500 EPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEE-EGERDETPSGAIDTRDTGSSEPQPPP 558
Query: 403 QGEKSATPSRKILDPNTGEPAPVLSSPP 430
+ +S P PN +P L+ PP
Sbjct: 559 EPPRSGPPL-----PNGLKPEFALALPP 581
Score = 39.3 bits (90), Expect = 0.010
Identities = 37/169 (21%), Positives = 68/169 (40%), Gaps = 1/169 (0%)
Query: 178 KPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPL 237
K L+ A L + A +A A R+ +L +H+ ++ + LA A +N
Sbjct: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMN 261
Query: 238 LRVINLNDNTFTE-KGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLK 296
LR + L DN + + + LK +++++ + V G I + ++ L
Sbjct: 262 LRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLV 321
Query: 297 ELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVL 345
L L ++ + + LE L+L N +G EG L+ L
Sbjct: 322 TLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL 370
>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 63.2 bits (152), Expect = 7e-10
Identities = 68/265 (25%), Positives = 105/265 (39%), Gaps = 40/265 (15%)
Query: 218 NGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVR 277
N + H G+ L L +NL N +G + L + R V + +
Sbjct: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
Query: 278 SKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN------ 331
+GAVA+A+ I P+L L+L EIK +A++ A+ L +LDL+
Sbjct: 388 CEGAVAVAEFIAES-PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAV 446
Query: 332 -TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDE------ 384
+ E L E+ G VLA +++++ + E A E + +DE
Sbjct: 447 KSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQ 506
Query: 385 --------------EEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPP 430
+ + + EEEEEEE GE+ TPS I +TG P PP
Sbjct: 507 NGAPSPAPSPDSDSDSDSDGEEEEEEE------GERDETPSGAIDTRDTGSSEP---QPP 557
Query: 431 PADVSTFLAFPS---PEKLLRLGPK 452
P + P+ PE L L P+
Sbjct: 558 PEPPRSGPPLPNGLKPEFALALPPE 582
Score = 53.1 bits (126), Expect = 7e-07
Identities = 90/388 (23%), Positives = 151/388 (38%), Gaps = 48/388 (12%)
Query: 65 AARVIAKALEKKSELKRCHWSDM-FTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNA 123
+A +A+AL +S L H + +GR P L++ + L EL L+DN
Sbjct: 220 SAPFVARALRIRSSLAVLHLENASLSGR-----PLMLLATA---LKMNMNLRELYLADNK 271
Query: 124 FGPDGVQGFEAL--LKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLA 181
+G+Q L L C +LQ L L N + G + L E +
Sbjct: 272 L--NGLQDSAQLGNLLKFNC-SLQILDLRNNHVLDSGLAYICEGLKEQRK---------G 319
Query: 182 LKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVI 241
L V N+L + G L +LE +++ N I + G+ L N + +
Sbjct: 320 LVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRL 379
Query: 242 NLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKL------ 295
L T +GAVA+AE + ++ ++ + +++ G +A++ A++ L
Sbjct: 380 GLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDR 439
Query: 296 ---KELNLSFCEIKRDAA----------LAVAEAMADKAELEKLDLNGNTLGEEGCEQLQ 342
KE SF E ++ L +A +K + +L + +
Sbjct: 440 EPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDD 499
Query: 343 EVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRG 402
E G + S D D + + +GEEEEEE E E +E + + EPQ
Sbjct: 500 EPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEE-EGERDETPSGAIDTRDTGSSEPQPPP 558
Query: 403 QGEKSATPSRKILDPNTGEPAPVLSSPP 430
+ +S P PN +P L+ PP
Sbjct: 559 EPPRSGPPL-----PNGLKPEFALALPP 581
Score = 39.3 bits (90), Expect = 0.010
Identities = 37/169 (21%), Positives = 68/169 (40%), Gaps = 1/169 (0%)
Query: 178 KPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPL 237
K L+ A L + A +A A R+ +L +H+ ++ + LA A +N
Sbjct: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMN 261
Query: 238 LRVINLNDNTFTE-KGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLK 296
LR + L DN + + + LK +++++ + V G I + ++ L
Sbjct: 262 LRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLV 321
Query: 297 ELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVL 345
L L ++ + + LE L+L N +G EG L+ L
Sbjct: 322 TLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL 370
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 62.4 bits (150), Expect = 1e-09
Identities = 36/89 (40%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 332 TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEE-------EEEAEEEEEEDE 384
T G+ G + E + G + + S S DE + + + E E EEE EEEEEE+E
Sbjct: 252 TKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEE 311
Query: 385 EEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
EEEEEEEEEEEE+ + Q ++S + R+
Sbjct: 312 EEEEEEEEEEEEDEESGNQSDRSGSSGRR 340
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/53 (50%), Positives = 32/53 (60%)
Query: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
E EEEE EEEEEE EEEEEE+EEEEE+EE + + K+ RK
Sbjct: 296 EQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRK 348
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 12/90 (13%)
Query: 324 EKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEED 383
E++D + + E EQL E E ++E+EEEEEE EEEEEE EE+EE
Sbjct: 281 ERVDSDSKSEVEALTEQLSEEEE------------EEEEEEEEEEEEEEEEEEEEDEESG 328
Query: 384 EEEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
+ + + ++ + PSRK
Sbjct: 329 NQSDRSGSSGRRKAKKKWRKDSPWVKPSRK 358
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 62.4 bits (150), Expect = 1e-09
Identities = 36/89 (40%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 332 TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEE-------EEEAEEEEEEDE 384
T G+ G + E + G + + S S DE + + + E E EEE EEEEEE+E
Sbjct: 252 TKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEE 311
Query: 385 EEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
EEEEEEEEEEEE+ + Q ++S + R+
Sbjct: 312 EEEEEEEEEEEEDEESGNQSDRSGSSGRR 340
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/53 (50%), Positives = 32/53 (60%)
Query: 361 EDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
E EEEE EEEEEE EEEEEE+EEEEE+EE + + K+ RK
Sbjct: 296 EQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRK 348
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 12/90 (13%)
Query: 324 EKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEED 383
E++D + + E EQL E E ++E+EEEEEE EEEEEE EE+EE
Sbjct: 281 ERVDSDSKSEVEALTEQLSEEEE------------EEEEEEEEEEEEEEEEEEEEDEESG 328
Query: 384 EEEEEEEEEEEEEEPQQRGQGEKSATPSRK 413
+ + + ++ + PSRK
Sbjct: 329 NQSDRSGSSGRRKAKKKWRKDSPWVKPSRK 358
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 62.4 bits (150), Expect = 1e-09
Identities = 33/74 (44%), Positives = 50/74 (67%), Gaps = 6/74 (8%)
Query: 333 LGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEE 392
+G G E ++++L K++ E+EEEE+E EE EEE EEE+EEDEEE +E+E
Sbjct: 1851 MGIFGDEDVKQIL------KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE 1904
Query: 393 EEEEEPQQRGQGEK 406
+EE+E ++ +GEK
Sbjct: 1905 DEEKEEEEAAEGEK 1918
Score = 58.5 bits (140), Expect = 2e-08
Identities = 29/71 (40%), Positives = 48/71 (67%), Gaps = 4/71 (5%)
Query: 334 GEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEE 393
G+E +Q+ +++E +V ++EDEEEE E E+EEE+ E+EEE +E+E+EE+EE
Sbjct: 1855 GDEDVKQILKMIE----PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
Query: 394 EEEEPQQRGQG 404
EE ++ +G
Sbjct: 1911 EEAAEGEKEEG 1921
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/62 (40%), Positives = 36/62 (58%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT 419
DED ++ + E E EEEEEEDEEEE EEE+EEE+E + ++ ++ +
Sbjct: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
Query: 420 GE 421
GE
Sbjct: 1916 GE 1917
Score = 30.4 bits (67), Expect = 4.7
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 1/68 (1%)
Query: 346 EGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGE 405
EG + K + E+E E E E E E E+ + E E+EE E EP ++ Q
Sbjct: 4464 EGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKK-QAP 4522
Query: 406 KSATPSRK 413
S P ++
Sbjct: 4523 PSPPPKKE 4530
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 62.4 bits (150), Expect = 1e-09
Identities = 33/74 (44%), Positives = 50/74 (67%), Gaps = 6/74 (8%)
Query: 333 LGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEE 392
+G G E ++++L K++ E+EEEE+E EE EEE EEE+EEDEEE +E+E
Sbjct: 1851 MGIFGDEDVKQIL------KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE 1904
Query: 393 EEEEEPQQRGQGEK 406
+EE+E ++ +GEK
Sbjct: 1905 DEEKEEEEAAEGEK 1918
Score = 58.5 bits (140), Expect = 2e-08
Identities = 29/71 (40%), Positives = 48/71 (67%), Gaps = 4/71 (5%)
Query: 334 GEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEE 393
G+E +Q+ +++E +V ++EDEEEE E E+EEE+ E+EEE +E+E+EE+EE
Sbjct: 1855 GDEDVKQILKMIE----PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
Query: 394 EEEEPQQRGQG 404
EE ++ +G
Sbjct: 1911 EEAAEGEKEEG 1921
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/62 (40%), Positives = 36/62 (58%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT 419
DED ++ + E E EEEEEEDEEEE EEE+EEE+E + ++ ++ +
Sbjct: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
Query: 420 GE 421
GE
Sbjct: 1916 GE 1917
Score = 30.4 bits (67), Expect = 4.7
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 1/68 (1%)
Query: 346 EGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGE 405
EG + K + E+E E E E E E E+ + E E+EE E EP ++ Q
Sbjct: 4469 EGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKK-QAP 4527
Query: 406 KSATPSRK 413
S P ++
Sbjct: 4528 PSPPPKKE 4535
>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
Length = 709
Score = 62.0 bits (149), Expect = 1e-09
Identities = 29/48 (60%), Positives = 38/48 (79%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
D E++EE EE EE+EE +E+ EE+EEEEEEEEEEEEEE ++ Q E+
Sbjct: 208 DVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDER 255
Score = 61.2 bits (147), Expect = 3e-09
Identities = 32/49 (65%), Positives = 39/49 (79%), Gaps = 2/49 (4%)
Query: 360 DEDEEEEEEGEEEEEEAE--EEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
+EDEE EE+ EE+EE E EEEEE+EEEEEEEEEEEEEE +Q + +K
Sbjct: 210 EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQK 258
Score = 60.8 bits (146), Expect = 3e-09
Identities = 26/41 (63%), Positives = 36/41 (87%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQ 400
+EDEE +E+GEEEEEE EEEEEE+EEEEEE E++E ++ ++
Sbjct: 220 EEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEE 260
Score = 58.9 bits (141), Expect = 1e-08
Identities = 28/47 (59%), Positives = 37/47 (78%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
+ED EE+EE EE+ EE EE +E+ EEEEEEEEEEEEEE ++ + E+
Sbjct: 206 EEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQ 252
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/82 (41%), Positives = 47/82 (57%), Gaps = 5/82 (6%)
Query: 335 EEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEE 394
EE E+ +EV E + + DED EEEEE EEEEEE EEEEEE+ E++E +++EE
Sbjct: 206 EEDVEEDEEVEEDAEEDEEV-----DEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEE 260
Query: 395 EEEPQQRGQGEKSATPSRKILD 416
+ R + S + S D
Sbjct: 261 GNDYDTRSEASDSGSESVSFTD 282
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/84 (40%), Positives = 50/84 (59%), Gaps = 2/84 (2%)
Query: 331 NTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEE 390
NT EE E ++E +E + A ++ DE+ EEE EEEEEE EEEEEE+EE E++E
Sbjct: 197 NTENEE--EGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254
Query: 391 EEEEEEEPQQRGQGEKSATPSRKI 414
+++EE + E S + S +
Sbjct: 255 RDQKEEGNDYDTRSEASDSGSESV 278
Score = 55.5 bits (132), Expect = 1e-07
Identities = 26/55 (47%), Positives = 38/55 (69%)
Query: 346 EGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQ 400
+G N + +D +E+EE E + EE+E +E+ E+EEEEEEEEEEEEEE ++
Sbjct: 194 QGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEE 248
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/111 (31%), Positives = 56/111 (50%), Gaps = 7/111 (6%)
Query: 303 CEIKRDAALAVAEAMADKAELEKLDLN--GNTLGEEGCEQLQEVLEGFNMAKVLASLSDD 360
C KRD D +E L+++ + + E++ G + + SD+
Sbjct: 134 CVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDE 193
Query: 361 E--DEEEEEEGEEEEEEAEEEEEEDEEEEEEEEE---EEEEEPQQRGQGEK 406
+ + E EEEG EE+ E +EE EED EE+EE +E EEEEE ++ + E+
Sbjct: 194 QGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEE 244
Score = 31.2 bits (69), Expect = 2.8
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 355 ASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKI 414
+S S E+ EE G + E + +E E EEE EE+ ++ + E+ A ++
Sbjct: 166 SSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEV 225
>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
Length = 727
Score = 62.0 bits (149), Expect = 1e-09
Identities = 29/48 (60%), Positives = 38/48 (79%)
Query: 359 DDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
D E++EE EE EE+EE +E+ EE+EEEEEEEEEEEEEE ++ Q E+
Sbjct: 208 DVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDER 255
Score = 61.2 bits (147), Expect = 3e-09
Identities = 32/49 (65%), Positives = 39/49 (79%), Gaps = 2/49 (4%)
Query: 360 DEDEEEEEEGEEEEEEAE--EEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
+EDEE EE+ EE+EE E EEEEE+EEEEEEEEEEEEEE +Q + +K
Sbjct: 210 EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQK 258
Score = 60.8 bits (146), Expect = 3e-09
Identities = 26/41 (63%), Positives = 36/41 (87%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQ 400
+EDEE +E+GEEEEEE EEEEEE+EEEEEE E++E ++ ++
Sbjct: 220 EEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEE 260
Score = 58.9 bits (141), Expect = 1e-08
Identities = 28/47 (59%), Positives = 37/47 (78%)
Query: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEK 406
+ED EE+EE EE+ EE EE +E+ EEEEEEEEEEEEEE ++ + E+
Sbjct: 206 EEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQ 252
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/82 (41%), Positives = 47/82 (57%), Gaps = 5/82 (6%)
Query: 335 EEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEE 394
EE E+ +EV E + + DED EEEEE EEEEEE EEEEEE+ E++E +++EE
Sbjct: 206 EEDVEEDEEVEEDAEEDEEV-----DEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEE 260
Query: 395 EEEPQQRGQGEKSATPSRKILD 416
+ R + S + S D
Sbjct: 261 GNDYDTRSEASDSGSESVSFTD 282
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/84 (40%), Positives = 50/84 (59%), Gaps = 2/84 (2%)
Query: 331 NTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEE 390
NT EE E ++E +E + A ++ DE+ EEE EEEEEE EEEEEE+EE E++E
Sbjct: 197 NTENEE--EGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254
Query: 391 EEEEEEEPQQRGQGEKSATPSRKI 414
+++EE + E S + S +
Sbjct: 255 RDQKEEGNDYDTRSEASDSGSESV 278
Score = 55.5 bits (132), Expect = 1e-07
Identities = 26/55 (47%), Positives = 38/55 (69%)
Query: 346 EGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQ 400
+G N + +D +E+EE E + EE+E +E+ E+EEEEEEEEEEEEEE ++
Sbjct: 194 QGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEE 248
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/111 (31%), Positives = 56/111 (50%), Gaps = 7/111 (6%)
Query: 303 CEIKRDAALAVAEAMADKAELEKLDLN--GNTLGEEGCEQLQEVLEGFNMAKVLASLSDD 360
C KRD D +E L+++ + + E++ G + + SD+
Sbjct: 134 CVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDE 193
Query: 361 E--DEEEEEEGEEEEEEAEEEEEEDEEEEEEEEE---EEEEEPQQRGQGEK 406
+ + E EEEG EE+ E +EE EED EE+EE +E EEEEE ++ + E+
Sbjct: 194 QGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEE 244
Score = 31.2 bits (69), Expect = 2.8
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 355 ASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKI 414
+S S E+ EE G + E + +E E EEE EE+ ++ + E+ A ++
Sbjct: 166 SSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEV 225
>gi|118600967 shroom family member 4 [Homo sapiens]
Length = 1493
Score = 61.6 bits (148), Expect = 2e-09
Identities = 34/77 (44%), Positives = 45/77 (58%), Gaps = 8/77 (10%)
Query: 355 ASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKI 414
A+ + ++++++ EEEEEE EEEEEE+EEEEEE EEEEEE P Q E S + +
Sbjct: 1117 AAQQQKQQQQQQKQQEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCAL-- 1174
Query: 415 LDPNTGEPAPVLSSPPP 431
P VL P P
Sbjct: 1175 ------NPEEVLEQPQP 1185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,025,236
Number of Sequences: 37866
Number of extensions: 1206384
Number of successful extensions: 94084
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1455
Number of HSP's successfully gapped in prelim test: 464
Number of HSP's that attempted gapping in prelim test: 21748
Number of HSP's gapped (non-prelim): 27112
length of query: 587
length of database: 18,247,518
effective HSP length: 108
effective length of query: 479
effective length of database: 14,157,990
effective search space: 6781677210
effective search space used: 6781677210
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.