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Search of human proteins with 4505913
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505913 PMS2 postmeiotic segregation increased 2 isoform a
[Homo sapiens]
(862 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505913 PMS2 postmeiotic segregation increased 2 isoform a [H... 1721 0.0
gi|239743246 PREDICTED: hypothetical protein XP_002342778 [Homo ... 316 5e-86
gi|169170512 PREDICTED: similar to Postmeiotic segregation incre... 316 5e-86
gi|189458898 postmeiotic segregation 1 isoform c [Homo sapiens] 183 7e-46
gi|4505911 postmeiotic segregation 1 isoform a [Homo sapiens] 181 2e-45
gi|189458896 postmeiotic segregation 1 isoform b [Homo sapiens] 176 8e-44
gi|4557757 MutL protein homolog 1 [Homo sapiens] 167 5e-41
gi|91992162 mutL homolog 3 isoform 1 [Homo sapiens] 83 1e-15
gi|91992160 mutL homolog 3 isoform 2 [Homo sapiens] 83 1e-15
gi|95147342 chromodomain helicase DNA binding protein 9 [Homo sa... 40 0.009
gi|7662022 lipin 2 [Homo sapiens] 39 0.027
gi|91105174 CD19 antigen [Homo sapiens] 38 0.035
gi|110347427 ubiquitin specific protease 34 [Homo sapiens] 38 0.035
gi|8922940 gamma-taxilin [Homo sapiens] 37 0.079
gi|120953251 neuron navigator 3 [Homo sapiens] 36 0.13
gi|60097902 filaggrin [Homo sapiens] 35 0.23
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 35 0.39
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 35 0.39
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 35 0.39
gi|58530876 melanoma antigen family C, 1 [Homo sapiens] 35 0.39
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 35 0.39
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 35 0.39
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 35 0.39
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 35 0.39
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 35 0.39
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 35 0.39
gi|61743930 zinc finger and BTB domain containing 41 [Homo sapiens] 35 0.39
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 34 0.51
gi|24308382 leukocyte receptor cluster member 8 [Homo sapiens] 34 0.51
gi|169173184 PREDICTED: hypothetical protein [Homo sapiens] 34 0.67
>gi|4505913 PMS2 postmeiotic segregation increased 2 isoform a [Homo
sapiens]
Length = 862
Score = 1721 bits (4458), Expect = 0.0
Identities = 862/862 (100%), Positives = 862/862 (100%)
Query: 1 MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD 60
MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD
Sbjct: 1 MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD 60
Query: 61 YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV 120
YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV
Sbjct: 61 YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV 120
Query: 121 TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE 180
TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE
Sbjct: 121 TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE 180
Query: 181 YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI 240
YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI
Sbjct: 181 YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI 240
Query: 241 PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA 300
PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA
Sbjct: 241 PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA 300
Query: 301 KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI 360
KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI
Sbjct: 301 KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI 360
Query: 361 GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL 420
GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL
Sbjct: 361 GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL 420
Query: 421 REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHG 480
REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHG
Sbjct: 421 REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHG 480
Query: 481 PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP 540
PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP
Sbjct: 481 PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP 540
Query: 541 ETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM 600
ETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM
Sbjct: 541 ETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM 600
Query: 601 SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA 660
SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA
Sbjct: 601 SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA 660
Query: 661 EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG 720
EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG
Sbjct: 661 EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG 720
Query: 721 QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGP 780
QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGP
Sbjct: 721 QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGP 780
Query: 781 QDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHP 840
QDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHP
Sbjct: 781 QDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHP 840
Query: 841 WNCPHGRPTMRHIANLGVISQN 862
WNCPHGRPTMRHIANLGVISQN
Sbjct: 841 WNCPHGRPTMRHIANLGVISQN 862
>gi|239743246 PREDICTED: hypothetical protein XP_002342778 [Homo
sapiens]
Length = 255
Score = 316 bits (810), Expect = 5e-86
Identities = 157/174 (90%), Positives = 168/174 (96%)
Query: 9 TEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEV 68
TEPAKAIKPIDRKSVHQICSG VVLSLSTAVK++V NSLDAGATNIDLKLKDYG+DLIEV
Sbjct: 24 TEPAKAIKPIDRKSVHQICSGPVVLSLSTAVKKIVGNSLDAGATNIDLKLKDYGMDLIEV 83
Query: 69 SDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHAS 128
S NGCGVEEENFEGLTLKHHTSKI+EFADLT+VETFGF+G+ALSSLCALSDVTISTCH S
Sbjct: 84 SGNGCGVEEENFEGLTLKHHTSKIREFADLTRVETFGFQGKALSSLCALSDVTISTCHVS 143
Query: 129 AKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYA 182
AKVGTRL+FDH+GKIIQKTPYP PRGTTVSV+QLFSTLPVRHKEFQRNIKK+ A
Sbjct: 144 AKVGTRLVFDHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKEFQRNIKKKRA 197
>gi|169170512 PREDICTED: similar to Postmeiotic segregation
increased 4-like protein [Homo sapiens]
Length = 255
Score = 316 bits (810), Expect = 5e-86
Identities = 157/174 (90%), Positives = 168/174 (96%)
Query: 9 TEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEV 68
TEPAKAIKPIDRKSVHQICSG VVLSLSTAVK++V NSLDAGATNIDLKLKDYG+DLIEV
Sbjct: 24 TEPAKAIKPIDRKSVHQICSGPVVLSLSTAVKKIVGNSLDAGATNIDLKLKDYGMDLIEV 83
Query: 69 SDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHAS 128
S NGCGVEEENFEGLTLKHHTSKI+EFADLT+VETFGF+G+ALSSLCALSDVTISTCH S
Sbjct: 84 SGNGCGVEEENFEGLTLKHHTSKIREFADLTRVETFGFQGKALSSLCALSDVTISTCHVS 143
Query: 129 AKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYA 182
AKVGTRL+FDH+GKIIQKTPYP PRGTTVSV+QLFSTLPVRHKEFQRNIKK+ A
Sbjct: 144 AKVGTRLVFDHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKEFQRNIKKKRA 197
>gi|189458898 postmeiotic segregation 1 isoform c [Homo sapiens]
Length = 770
Score = 183 bits (464), Expect = 7e-46
Identities = 211/870 (24%), Positives = 358/870 (41%), Gaps = 132/870 (15%)
Query: 15 IKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCG 74
+K + +V + S Q++ S+ + VKEL+ENSLDAGAT++D+KL++YG D IEV DNG G
Sbjct: 1 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG 60
Query: 75 VEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTR 134
++ + + +K++TSKI DL + T+GFRGEAL S+C +++V I+T A+ T+
Sbjct: 61 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ 120
Query: 135 LMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKK---EYAKMVQVLHAY 191
+ D +G I+ + P +GTTV+ +LF LPVR K+F KK E K+ +L ++
Sbjct: 121 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVR-KQFYSTAKKCKDEIKKIQDLLMSF 179
Query: 192 CIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSV 251
I+ +R+ + + + K + SV G + ++ F +
Sbjct: 180 GILKPDLRIVFVH-----NKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQI 234
Query: 252 CEEYGLSCSDALHNLFYISGFISQC--THGVGRSST-DRQFFFINRRPCDPAKVCRLVNE 308
Y+SGF+ +C H ST +R F FIN RP + +L+
Sbjct: 235 ----------------YLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRH 278
Query: 309 VYHM----YNRHQYPFVVLNISVDSECVDINVTPDKRQILLQ-EEKLLLAV--LKTSLIG 361
Y++ + YP L I V + VD+N+TPDK Q+LLQ +E +L+A+ L T+ G
Sbjct: 279 HYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYG 338
Query: 362 MFDS----DVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSI 417
S + NK +VS ++ L K D+ VE ++ S D S+
Sbjct: 339 PLPSTNSYENNKTDVSAADIV-----LSKTAETDVLFNKVESSGKNYS------NVDTSV 387
Query: 418 ----SRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKE 473
+ + S ++T + H + + + +T A D + E
Sbjct: 388 IPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWE 447
Query: 474 AVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHV 533
+ + + + + +D G + + G SSE +A D S+ ++
Sbjct: 448 NSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISA----DEWSRGNI 503
Query: 534 DSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQK 593
++ V ++ CK N P E++ + D C K
Sbjct: 504 LKN----SVGENIEPVKILVPEKSLPCKV----SNNNYPIP-------EQMNLNEDSCNK 548
Query: 594 LVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKIC 653
N D + +V ++ +V+ S S+L + H Q +
Sbjct: 549 KSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQ----DHRPQ-------------FLI 591
Query: 654 PGENQAAEDELR--KEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEM 711
+ ED +E+ KT+ +E E + FN + L + A D++Y+
Sbjct: 592 ENPKTSLEDATLQIEELWKTL-SEEEKLNLFNGSHYLDVLYK------MTADDQRYS--- 641
Query: 712 LQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLP 771
T L RL A NGF + +TE I
Sbjct: 642 --GSTYLSDPRLTA-----------------------NGFKIKLIPGVSITENYLEIEGM 676
Query: 772 TSKNWTFGPQDVDELIFMLSDSPG---VMCRPSRVKQMFASRACRKSVMIGTALNTSEMK 828
+ +G D+ E++ + + CRP +V A R S + L+ +++
Sbjct: 677 ANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQ 736
Query: 829 KLITHMGEM--DHPWNCPHGRPTMRHIANL 856
+I M + C HGRP H+ L
Sbjct: 737 DIIYRMKHQFGNEIKECVHGRPFFHHLTYL 766
>gi|4505911 postmeiotic segregation 1 isoform a [Homo sapiens]
Length = 932
Score = 181 bits (460), Expect = 2e-45
Identities = 125/376 (33%), Positives = 199/376 (52%), Gaps = 39/376 (10%)
Query: 15 IKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCG 74
+K + +V + S Q++ S+ + VKEL+ENSLDAGAT++D+KL++YG D IEV DNG G
Sbjct: 1 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG 60
Query: 75 VEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTR 134
++ + + +K++TSKI DL + T+GFRGEAL S+C +++V I+T A+ T+
Sbjct: 61 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ 120
Query: 135 LMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKK---EYAKMVQVLHAY 191
+ D +G I+ + P +GTTV+ +LF LPVR K+F KK E K+ +L ++
Sbjct: 121 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVR-KQFYSTAKKCKDEIKKIQDLLMSF 179
Query: 192 CIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSV 251
I+ +R+ + + + K + SV G + ++ F +
Sbjct: 180 GILKPDLRIVFVH-----NKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQI 234
Query: 252 CEEYGLSCSDALHNLFYISGFISQC--THGVGRSST-DRQFFFINRRPCDPAKVCRLVNE 308
Y+SGF+ +C H ST +R F FIN RP + +L+
Sbjct: 235 ----------------YLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRH 278
Query: 309 VYHM----YNRHQYPFVVLNISVDSECVDINVTPDKRQILLQ-EEKLLLAV--LKTSLIG 361
Y++ + YP L I V + VD+N+TPDK Q+LLQ +E +L+A+ L T+ G
Sbjct: 279 HYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYG 338
Query: 362 MFDS----DVNKLNVS 373
S + NK +VS
Sbjct: 339 PLPSTNSYENNKTDVS 354
Score = 30.4 bits (67), Expect = 7.4
Identities = 26/113 (23%), Positives = 44/113 (38%), Gaps = 5/113 (4%)
Query: 749 NGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPG---VMCRPSRVKQ 805
NGF + +TE I + +G D+ E++ + + CRP +V
Sbjct: 816 NGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVIS 875
Query: 806 MFASRACRKSVMIGTALNTSEMKKLITHMGEM--DHPWNCPHGRPTMRHIANL 856
A R S + L+ +++ +I M + C HGRP H+ L
Sbjct: 876 YLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLTYL 928
>gi|189458896 postmeiotic segregation 1 isoform b [Homo sapiens]
Length = 893
Score = 176 bits (446), Expect = 8e-44
Identities = 126/375 (33%), Positives = 193/375 (51%), Gaps = 76/375 (20%)
Query: 15 IKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCG 74
+K + +V + S Q++ S+ + VKEL+ENSLDAGAT++D+KL++YG D IEV DNG G
Sbjct: 1 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG 60
Query: 75 VEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTR 134
++ + + +K++TSKI DL + T+GFRGEAL S+C +++V I+T A+ T+
Sbjct: 61 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ 120
Query: 135 LMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKK--EYAKMVQVLHAYC 192
+ D +G I+ + P +GTTV+ +LF LPVR K+F KK + K +Q L
Sbjct: 121 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVR-KQFYSTAKKCKDEIKKIQDL---- 175
Query: 193 IISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVC 252
++S GI +K ++ VF
Sbjct: 176 LMSFGI------------------------LKPDLRIVF--------------------- 190
Query: 253 EEYGLSCSDALHNLFYISGFISQCT--HGVGRSST-DRQFFFINRRPCDPAKVCRLVNEV 309
+HN Y+SGF+ +C H ST +R F FIN RP + +L+
Sbjct: 191 ----------VHNKIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHH 240
Query: 310 YHMY----NRHQYPFVVLNISVDSECVDINVTPDKRQILLQ-EEKLLLAV--LKTSLIGM 362
Y++ + YP L I V + VD+N+TPDK Q+LLQ +E +L+A+ L T+ G
Sbjct: 241 YNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGP 300
Query: 363 FDS----DVNKLNVS 373
S + NK +VS
Sbjct: 301 LPSTNSYENNKTDVS 315
Score = 30.4 bits (67), Expect = 7.4
Identities = 26/113 (23%), Positives = 44/113 (38%), Gaps = 5/113 (4%)
Query: 749 NGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPG---VMCRPSRVKQ 805
NGF + +TE I + +G D+ E++ + + CRP +V
Sbjct: 777 NGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVIS 836
Query: 806 MFASRACRKSVMIGTALNTSEMKKLITHMGEM--DHPWNCPHGRPTMRHIANL 856
A R S + L+ +++ +I M + C HGRP H+ L
Sbjct: 837 YLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLTYL 889
>gi|4557757 MutL protein homolog 1 [Homo sapiens]
Length = 756
Score = 167 bits (422), Expect = 5e-41
Identities = 119/384 (30%), Positives = 205/384 (53%), Gaps = 36/384 (9%)
Query: 12 AKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDN 71
A I+ +D V++I +G+V+ + A+KE++EN LDA +T+I + +K+ G+ LI++ DN
Sbjct: 5 AGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDN 64
Query: 72 GCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKV 131
G G+ +E+ + + + TSK+Q F DL + T+GFRGEAL+S+ ++ VTI+T A K
Sbjct: 65 GTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKC 124
Query: 132 GTRLMFDHNGKIIQKTPYPRP----RGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQV 187
R + +GK+ K P P+P +GT ++V+ LF + R K +N +EY K+++V
Sbjct: 125 AYRASYS-DGKL--KAP-PKPCAGNQGTQITVEDLFYNIATRRKAL-KNPSEEYGKILEV 179
Query: 188 LHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPP 247
+ Y + +AGI S QG+ V T + S +NI S+FG + LI
Sbjct: 180 VGRYSVHNAGISFSVKK---QGETVADVRTLPNASTVDNIRSIFGNAVSRELI------- 229
Query: 248 SDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVN 307
+ CE+ L+ F ++G+IS + V + FIN R + + + +
Sbjct: 230 -EIGCEDKTLA--------FKMNGYISNANYSVKKCIF---LLFINHRLVESTSLRKAIE 277
Query: 308 EVYHMY-NRHQYPFVVLNISVDSECVDINVTPDKRQI-LLQEEKLLLAV---LKTSLIGM 362
VY Y ++ +PF+ L++ + + VD+NV P K ++ L EE +L V +++ L+G
Sbjct: 278 TVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGS 337
Query: 363 FDSDVNKLNVSQQPLLDVEGNLIK 386
S + L G ++K
Sbjct: 338 NSSRMYFTQTLLPGLAGPSGEMVK 361
>gi|91992162 mutL homolog 3 isoform 1 [Homo sapiens]
Length = 1453
Score = 83.2 bits (204), Expect = 1e-15
Identities = 78/293 (26%), Positives = 129/293 (44%), Gaps = 51/293 (17%)
Query: 28 SGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKH 87
SG + SL V+EL NS+DA A + +++ + ++V DNG G+ ++ E + ++
Sbjct: 15 SGLAISSLGQCVEELALNSIDAEAKCVAVRV-NMETFQVQVIDNGFGMGSDDVEKVGNRY 73
Query: 88 HTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKT 147
TSK DL +GFRGEAL+++ ++ + + + T + +GK ++
Sbjct: 74 FTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKAC 133
Query: 148 PYPRPR---GTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTN 204
R GTTV+V LF LPVR K + E+ K+ Q + A ++ I S N
Sbjct: 134 EADVTRASAGTTVTVYNLFYQLPVRRKCMDPRL--EFEKVRQRIEALSLMHPSISFSLRN 191
Query: 205 QLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEE----YGLSCS 260
+ GS+ +QLP + VC YGL S
Sbjct: 192 DVS--------------------GSM-----------VLQLPKTKDVCSRFCQIYGLGKS 220
Query: 261 DALHNL------FYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVN 307
L + F +SG+IS H + + QF F+N+R K+ +L++
Sbjct: 221 QKLREISFKYKEFELSGYISSEAH----YNKNMQFLFVNKRLVLRTKLHKLID 269
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/230 (23%), Positives = 98/230 (42%), Gaps = 37/230 (16%)
Query: 669 SKTMFAEMEIIGQFNLGFII----TKLNED-------IFIVDQHATDEKYNFEML----- 712
+K M M+++ Q + FI TK E+ + +VDQHA E+ E L
Sbjct: 1182 TKGMIHSMQVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSY 1241
Query: 713 -QQHTVLQGQR------LIAPQTLNLTAVNEAVLI---ENLE------IFRKNGFDFVID 756
+Q G++ LI P + +T +L +NLE +F V+
Sbjct: 1242 EKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLV 1301
Query: 757 ENAPVT----ERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVM-CRPSRVKQMFASRA 811
P+ E +L ++ + + + E + +L + G+ P V+++ AS+A
Sbjct: 1302 GKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQA 1361
Query: 812 CRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQ 861
C ++ L+ E +LI + P+ C HGRP+M +A++ + Q
Sbjct: 1362 CHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQ 1411
>gi|91992160 mutL homolog 3 isoform 2 [Homo sapiens]
Length = 1429
Score = 83.2 bits (204), Expect = 1e-15
Identities = 78/293 (26%), Positives = 129/293 (44%), Gaps = 51/293 (17%)
Query: 28 SGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKH 87
SG + SL V+EL NS+DA A + +++ + ++V DNG G+ ++ E + ++
Sbjct: 15 SGLAISSLGQCVEELALNSIDAEAKCVAVRV-NMETFQVQVIDNGFGMGSDDVEKVGNRY 73
Query: 88 HTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKT 147
TSK DL +GFRGEAL+++ ++ + + + T + +GK ++
Sbjct: 74 FTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKAC 133
Query: 148 PYPRPR---GTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTN 204
R GTTV+V LF LPVR K + E+ K+ Q + A ++ I S N
Sbjct: 134 EADVTRASAGTTVTVYNLFYQLPVRRKCMDPRL--EFEKVRQRIEALSLMHPSISFSLRN 191
Query: 205 QLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEE----YGLSCS 260
+ GS+ +QLP + VC YGL S
Sbjct: 192 DVS--------------------GSM-----------VLQLPKTKDVCSRFCQIYGLGKS 220
Query: 261 DALHNL------FYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVN 307
L + F +SG+IS H + + QF F+N+R K+ +L++
Sbjct: 221 QKLREISFKYKEFELSGYISSEAH----YNKNMQFLFVNKRLVLRTKLHKLID 269
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/80 (27%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 783 VDELIFMLSDSPGVM-CRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPW 841
+ E + +L + G+ P V+++ AS+AC ++ L+ E +LI + P+
Sbjct: 1308 IREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPF 1367
Query: 842 NCPHGRPTMRHIANLGVISQ 861
C HGRP+M +A++ + Q
Sbjct: 1368 QCAHGRPSMLPLADIDHLEQ 1387
>gi|95147342 chromodomain helicase DNA binding protein 9 [Homo
sapiens]
Length = 2881
Score = 40.0 bits (92), Expect = 0.009
Identities = 58/224 (25%), Positives = 88/224 (39%), Gaps = 31/224 (13%)
Query: 343 ILLQEEKLLLAVLKTSLIGMFDSD--------VNKLNVSQQPLLDVEGNLIKMHAADLEK 394
+L Q + L A TSL + D+ V N+ ++P E ++ + L K
Sbjct: 2015 LLQQYQVALSASPLTSLPRLLDAKGIILEEMKVKSENLKEEPQSSEEESMSSVETRTLIK 2074
Query: 395 --PMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPR-RSPLGQKR 451
P+ K P TG++K R + R TE P TP P + P KR
Sbjct: 2075 SEPVSPKNGVLPQA-TGDQKSGGKCETDRRMVAAR--TE-----PLTPNPASKKPRVHKR 2126
Query: 452 GMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDT 511
G SSS S + S++ + + SSS S S GS+S S S
Sbjct: 2127 GSESSSDSDSDSERSSCSSRSSSSSSSSSCS----------HSRSGSSS--SSSSSCSSA 2174
Query: 512 GSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSNQ 555
S SS ++SS S E DS E+ + +S + + + +
Sbjct: 2175 SSSSSSSTSSSSSSSSSSSEESDSDEEEAQKRESTTHMKAYDEE 2218
>gi|7662022 lipin 2 [Homo sapiens]
Length = 896
Score = 38.5 bits (88), Expect = 0.027
Identities = 31/121 (25%), Positives = 47/121 (38%), Gaps = 1/121 (0%)
Query: 404 PSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAIS 463
P L + + + L A +E+KP + K P + KR +
Sbjct: 348 PPLESTQISSMLDADHLPNAALAEAPSESKP-AAKVDSPSKKKGVHKRSQHQGPDDIYLD 406
Query: 464 DKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASS 523
D L P+ A+ S+P R E D+ GS S S G + D+G+ C S+ A
Sbjct: 407 DLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDL 466
Query: 524 P 524
P
Sbjct: 467 P 467
>gi|91105174 CD19 antigen [Homo sapiens]
Length = 556
Score = 38.1 bits (87), Expect = 0.035
Identities = 41/163 (25%), Positives = 64/163 (39%), Gaps = 24/163 (14%)
Query: 415 VSISRLREAFSLRH-----TTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLR 469
V I L+ A LR T + TP P P Q +LS T + G+ R
Sbjct: 308 VGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTS----GLGR 363
Query: 470 PQKEAVS-SSHGPSDPTDRAEVEKDSGHGSTSV--------DSEGFSIPDTGSHCSSEYA 520
Q+ A PS ++V+ D GS S + EG+ PD+
Sbjct: 364 AQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYEN 423
Query: 521 ASSPG------DRGSQEHVDSQEKAPETDDSFSDVDCHSNQED 557
S+ G D E+ + + PE +DSFS+ + + N+++
Sbjct: 424 DSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDE 466
>gi|110347427 ubiquitin specific protease 34 [Homo sapiens]
Length = 3546
Score = 38.1 bits (87), Expect = 0.035
Identities = 46/175 (26%), Positives = 61/175 (34%), Gaps = 23/175 (13%)
Query: 394 KPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGM 453
K + KQ SL ++ I +E LR T +P P SP
Sbjct: 479 KAQLSKQSSFASLLN----TNIPIGNKKEEEELRRT------APSPWSPAASPQSSDNSD 528
Query: 454 LSSSTSGAIS--------DKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEG 505
S I K V + + S G SD T + + SG GS+S S+G
Sbjct: 529 THQSGGSDIEMDEQLINRTKHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDG 588
Query: 506 FSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGC 560
S SH S +A SPG E + E E D+ D D N + C
Sbjct: 589 SSNEVNSSHASQ--SAGSPGSEVQSEDIADIEALKEEDE---DDDHGHNPPKSSC 638
>gi|8922940 gamma-taxilin [Homo sapiens]
Length = 528
Score = 37.0 bits (84), Expect = 0.079
Identities = 49/203 (24%), Positives = 88/203 (43%), Gaps = 17/203 (8%)
Query: 529 SQEHVDSQEKAPETDDSFSDVDCHSNQEDT-GCKFRVLPQPTN-LATPNTKRF----KKE 582
S+E + E + D D +C+ N+E T G + +L Q N L+TP K K
Sbjct: 105 SREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYA 164
Query: 583 EILSSSDICQKLVNTQDMSASQVDVAVKI-----NKKVVPLDFSMSSLAKRIKQLHHEAQ 637
++L S QK + +Q+ V K+ + K + + SL + + Q H++
Sbjct: 165 DLLEESRSVQKQMKILQKKQAQI-VKEKVHLQSEHSKAILARSKLESLCREL-QRHNKTL 222
Query: 638 QSEGEQNYR--KFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQ-FNLGFIITKLNED 694
+ E Q R + R K Q DE++ ++ + ++ + LG + KL E
Sbjct: 223 KEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQ 282
Query: 695 IFIVDQHATDEKYNFEMLQQHTV 717
+ ++H D+ + + LQQ V
Sbjct: 283 YALREEH-IDKVFKRKELQQQLV 304
>gi|120953251 neuron navigator 3 [Homo sapiens]
Length = 2363
Score = 36.2 bits (82), Expect = 0.13
Identities = 59/273 (21%), Positives = 109/273 (39%), Gaps = 37/273 (13%)
Query: 402 QSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGA 461
QS +RTG + S L E+ L T K TP R++ + + L S ++G
Sbjct: 1397 QSLLMRTGSVR-----STLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGG 1451
Query: 462 ISDKGVLRP--QKEAVSSSHGPS-------DPTDRAE--VEKDSGHGSTSVDSE--GFSI 508
+ D G P A+SSS PT+ ++ + S S S+ ++ F +
Sbjct: 1452 LQDTGNQSPLVSPSAMSSSAAGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDL 1511
Query: 509 PDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQP 568
D C GS ++ + +A SF D S +E G ++
Sbjct: 1512 YDDSQLC------------GSATSLEERPRAISHSGSFRD----SMEEVHGSSLSLVSST 1555
Query: 569 TNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKR 628
++L + ++ E+I + ++LV +Q+ A+ V + S+ ++ R
Sbjct: 1556 SSLYSTAEEKAHSEQI---HKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGR 1612
Query: 629 IKQLHHEAQQSEGEQNYRKFRAKICPGENQAAE 661
++ L A+Q E E + ++ +N AA+
Sbjct: 1613 LQSLTMTAEQKESELIELRETIEMLKAQNSAAQ 1645
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 35.4 bits (80), Expect = 0.23
Identities = 36/143 (25%), Positives = 53/143 (37%), Gaps = 15/143 (10%)
Query: 404 PSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAIS 463
PS R G + S++ + S T + S + + R G S S + +
Sbjct: 1564 PSTRAGSSRH----SQVGQGESAGSKTSRRQGSSVSQD--RDSEGHSEDSERRSESASRN 1617
Query: 464 DKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSH----CSSEY 519
G R Q S HG +P E GH + S G +T S S E
Sbjct: 1618 HYGSAREQ-----SRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQ 1672
Query: 520 AASSPGDRGSQEHVDSQEKAPET 542
A SSPG+R H S + + ++
Sbjct: 1673 ARSSPGERHGSRHQQSADSSTDS 1695
Score = 33.1 bits (74), Expect = 1.1
Identities = 35/139 (25%), Positives = 51/139 (36%), Gaps = 24/139 (17%)
Query: 428 HTTENKPHSP--KTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPT 485
H TE+ H + E RS G++ G R Q+ A SS H
Sbjct: 1332 HHTESSSHGQAVSSHEQARSSPGERHGS---------------RHQQSADSSRHSGIGHR 1376
Query: 486 DRAEVEKDSGH----GSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQ--EKA 539
+ +DSGH GS +SEG S D+ + S + + P + +E Q E +
Sbjct: 1377 QASSAVRDSGHRGSSGSQVTNSEGHS-EDSDTQSVSAHGQAGPHQQSHKESARGQSGESS 1435
Query: 540 PETDDSFSDVDCHSNQEDT 558
+ V H E T
Sbjct: 1436 GRSRSFLYQVSSHEQSEST 1454
Score = 32.7 bits (73), Expect = 1.5
Identities = 39/173 (22%), Positives = 61/173 (35%), Gaps = 23/173 (13%)
Query: 371 NVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTT 430
+ S+Q D + H+ D S + G+E+ S + + S+ +
Sbjct: 1215 SASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDS 1274
Query: 431 ENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEV 490
+++ HS + LS S S + G R Q S G P E
Sbjct: 1275 DSERHSDDSER------------LSGSASR--NHHGSSREQ-----SRDGSRHPGFHQED 1315
Query: 491 EKDSGHGSTSVDSEGFSIPDTGSH----CSSEYAASSPGDRGSQEHVDSQEKA 539
GH + S G ++ SH S E A SSPG+R H S + +
Sbjct: 1316 RASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSS 1368
Score = 32.0 bits (71), Expect = 2.5
Identities = 21/67 (31%), Positives = 26/67 (38%), Gaps = 4/67 (5%)
Query: 477 SSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSH----CSSEYAASSPGDRGSQEH 532
S HG P E GH + S G +T S S E A SSPG+R H
Sbjct: 978 SRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRH 1037
Query: 533 VDSQEKA 539
S + +
Sbjct: 1038 QQSADSS 1044
Score = 31.6 bits (70), Expect = 3.3
Identities = 36/161 (22%), Positives = 56/161 (34%), Gaps = 10/161 (6%)
Query: 385 IKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRR 444
I+ A D ++E+ R+ + K ++R R +T++ +T + R
Sbjct: 239 IQDEAYDTTDSLLEENKIYERSRSSDGKSSSQVNRSRH----ENTSQVPLQESRTRKRRG 294
Query: 445 SPLGQKRGMLSSSTSGAISDKGVLRPQKEAV--SSSHGPSDPTDRAEVEKDSGHGSTSVD 502
S + Q R S R + S G P E GH + S
Sbjct: 295 SRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSR 354
Query: 503 SEGFSIPDTGSH----CSSEYAASSPGDRGSQEHVDSQEKA 539
G +T S S E A SSPG+R H S + +
Sbjct: 355 QSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADSS 395
Score = 31.2 bits (69), Expect = 4.3
Identities = 31/126 (24%), Positives = 47/126 (37%), Gaps = 7/126 (5%)
Query: 439 TPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGH-- 496
T + S GQ + S A G + A SS H + + +DSGH
Sbjct: 682 TRHTQNSSSGQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRG 741
Query: 497 --GSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHV--DSQEKAPETDDSFSDVDCH 552
GS + DSEG S D+ + S + + + QE S E++ + V H
Sbjct: 742 SSGSQATDSEGHS-EDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTH 800
Query: 553 SNQEDT 558
E +
Sbjct: 801 KQSESS 806
Score = 30.0 bits (66), Expect = 9.6
Identities = 20/67 (29%), Positives = 25/67 (37%), Gaps = 4/67 (5%)
Query: 477 SSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSH----CSSEYAASSPGDRGSQEH 532
S HG P E GH + G +T S S E A SSPG+R H
Sbjct: 3247 SRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRH 3306
Query: 533 VDSQEKA 539
S + +
Sbjct: 3307 QQSADSS 3313
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 34.7 bits (78), Expect = 0.39
Identities = 51/230 (22%), Positives = 86/230 (37%), Gaps = 36/230 (15%)
Query: 423 AFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSS---STSGAISDKGVLRPQK----EAV 475
A S R T + P + + S G + +S S+S + SDK + + E V
Sbjct: 282 ASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKV 341
Query: 476 SSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASS---PGDRGSQEH 532
+ P + EVE+ + S SE + S SS+ ++ S P SQ
Sbjct: 342 KAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGP 401
Query: 533 V-----DSQEKAPETDD-------------------SFSDVDCHSNQEDTGCKFRVLPQP 568
+ D Q + + DD SFSD + N D+ R P P
Sbjct: 402 LRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSE-SDNSADSSLPSREPPPP 460
Query: 569 TNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPL 618
PN+K + S S +K++ + D V+++++++ L
Sbjct: 461 QKPPPPNSKVSGRRSPESCSK-PEKILKKGTYDKAYTDELVELHRRLMAL 509
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 34.7 bits (78), Expect = 0.39
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 30/167 (17%)
Query: 398 EKQDQSPSLRTGEEKKDVSISR---------LREAFSLRHTTENKPHSPKTPEPRRSPLG 448
E+++Q R EE++ +R +RE +S + + SP P R LG
Sbjct: 175 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 234
Query: 449 -----------QKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHG 497
++R +LS ISD E+ S+ G + E E++ G
Sbjct: 235 DGRKPVKEEKMEERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 292
Query: 498 STSVDS------EGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEK 538
STS +S E +TGS +SE A+ + S+E + E+
Sbjct: 293 STSEESEEEEEEEEEEEEETGS--NSEEASEQSAEEVSEEEMSEDEE 337
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 34.7 bits (78), Expect = 0.39
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 30/167 (17%)
Query: 398 EKQDQSPSLRTGEEKKDVSISR---------LREAFSLRHTTENKPHSPKTPEPRRSPLG 448
E+++Q R EE++ +R +RE +S + + SP P R LG
Sbjct: 185 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 244
Query: 449 -----------QKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHG 497
++R +LS ISD E+ S+ G + E E++ G
Sbjct: 245 DGRKPVKEEKMEERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 302
Query: 498 STSVDS------EGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEK 538
STS +S E +TGS +SE A+ + S+E + E+
Sbjct: 303 STSEESEEEEEEEEEEEEETGS--NSEEASEQSAEEVSEEEMSEDEE 347
>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
Length = 1142
Score = 34.7 bits (78), Expect = 0.39
Identities = 40/147 (27%), Positives = 59/147 (40%), Gaps = 9/147 (6%)
Query: 415 VSISRLREAFSLRHTTENKPHSPKTPE-PRRSPLGQKRGMLSSSTSGAISDKGVLRPQKE 473
VSI + SL + P SP PE P +SPL + S T ++ PQ
Sbjct: 744 VSICSSSTSLSLPQSFPESPQSP--PEGPAQSPLQRPVSSFFSYTLASLLQSSHESPQ-- 799
Query: 474 AVSSSHGPSDPTDRAEVEK--DSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQE 531
S GP+ ++ V S S S S S P + S S+ + SP
Sbjct: 800 --SPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPVIS 857
Query: 532 HVDSQEKAPETDDSFSDVDCHSNQEDT 558
S +P +++S S VD +++ DT
Sbjct: 858 FSSSTSLSPFSEESSSPVDEYTSSSDT 884
Score = 33.5 bits (75), Expect = 0.87
Identities = 34/115 (29%), Positives = 48/115 (41%), Gaps = 5/115 (4%)
Query: 425 SLRHTTENKPHSPKTPE-PRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSD 483
SL ++ P SP PE P +SPL SSTS ++S + + SSS S
Sbjct: 789 SLLQSSHESPQSP--PEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSS 846
Query: 484 PTDRAEVEKDSGHGSTSVD--SEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQ 536
P + S STS+ SE S P SS+ S S+ ++S+
Sbjct: 847 PESPLQSPVISFSSSTSLSPFSEESSSPVDEYTSSSDTLLESDSLTDSESLIESE 901
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 34.7 bits (78), Expect = 0.39
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 30/167 (17%)
Query: 398 EKQDQSPSLRTGEEKKDVSISR---------LREAFSLRHTTENKPHSPKTPEPRRSPLG 448
E+++Q R EE++ +R +RE +S + + SP P R LG
Sbjct: 176 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 235
Query: 449 -----------QKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHG 497
++R +LS ISD E+ S+ G + E E++ G
Sbjct: 236 DGRKPVKEEKMEERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 293
Query: 498 STSVDS------EGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEK 538
STS +S E +TGS +SE A+ + S+E + E+
Sbjct: 294 STSEESEEEEEEEEEEEEETGS--NSEEASEQSAEEVSEEEMSEDEE 338
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 34.7 bits (78), Expect = 0.39
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 30/167 (17%)
Query: 398 EKQDQSPSLRTGEEKKDVSISR---------LREAFSLRHTTENKPHSPKTPEPRRSPLG 448
E+++Q R EE++ +R +RE +S + + SP P R LG
Sbjct: 185 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 244
Query: 449 -----------QKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHG 497
++R +LS ISD E+ S+ G + E E++ G
Sbjct: 245 DGRKPVKEEKMEERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 302
Query: 498 STSVDS------EGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEK 538
STS +S E +TGS +SE A+ + S+E + E+
Sbjct: 303 STSEESEEEEEEEEEEEEETGS--NSEEASEQSAEEVSEEEMSEDEE 347
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 34.7 bits (78), Expect = 0.39
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 30/167 (17%)
Query: 398 EKQDQSPSLRTGEEKKDVSISR---------LREAFSLRHTTENKPHSPKTPEPRRSPLG 448
E+++Q R EE++ +R +RE +S + + SP P R LG
Sbjct: 153 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 212
Query: 449 -----------QKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHG 497
++R +LS ISD E+ S+ G + E E++ G
Sbjct: 213 DGRKPVKEEKMEERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 270
Query: 498 STSVDS------EGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEK 538
STS +S E +TGS +SE A+ + S+E + E+
Sbjct: 271 STSEESEEEEEEEEEEEEETGS--NSEEASEQSAEEVSEEEMSEDEE 315
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 34.7 bits (78), Expect = 0.39
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 30/167 (17%)
Query: 398 EKQDQSPSLRTGEEKKDVSISR---------LREAFSLRHTTENKPHSPKTPEPRRSPLG 448
E+++Q R EE++ +R +RE +S + + SP P R LG
Sbjct: 142 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 201
Query: 449 -----------QKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHG 497
++R +LS ISD E+ S+ G + E E++ G
Sbjct: 202 DGRKPVKEEKMEERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 259
Query: 498 STSVDS------EGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEK 538
STS +S E +TGS +SE A+ + S+E + E+
Sbjct: 260 STSEESEEEEEEEEEEEEETGS--NSEEASEQSAEEVSEEEMSEDEE 304
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 34.7 bits (78), Expect = 0.39
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 30/167 (17%)
Query: 398 EKQDQSPSLRTGEEKKDVSISR---------LREAFSLRHTTENKPHSPKTPEPRRSPLG 448
E+++Q R EE++ +R +RE +S + + SP P R LG
Sbjct: 187 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 246
Query: 449 -----------QKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHG 497
++R +LS ISD E+ S+ G + E E++ G
Sbjct: 247 DGRKPVKEEKMEERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 304
Query: 498 STSVDS------EGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEK 538
STS +S E +TGS +SE A+ + S+E + E+
Sbjct: 305 STSEESEEEEEEEEEEEEETGS--NSEEASEQSAEEVSEEEMSEDEE 349
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 34.7 bits (78), Expect = 0.39
Identities = 37/155 (23%), Positives = 61/155 (39%), Gaps = 16/155 (10%)
Query: 454 LSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGS 513
+SS S A ++G P+ + + P + +K GS D E F D G
Sbjct: 216 MSSDASDASGEEGGRVPKAKKKA-------PLAKGGRKKKKKKGS---DDEAFEDSDDGD 265
Query: 514 HCSSEYAASSPGDRGSQEHVDSQEKAPETD------DSFSDVDCHSNQEDTGCKFRVLPQ 567
E S G SQE +S+ KAP+ + D SD S +E + + +
Sbjct: 266 FEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEE 325
Query: 568 PTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSA 602
TP K+ +K+ S + ++++ SA
Sbjct: 326 EKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA 360
>gi|61743930 zinc finger and BTB domain containing 41 [Homo sapiens]
Length = 909
Score = 34.7 bits (78), Expect = 0.39
Identities = 44/184 (23%), Positives = 71/184 (38%), Gaps = 27/184 (14%)
Query: 377 LLDVEGNLIKMHAADLEKPMVEKQDQSPSLR--TGEEKKDVSISRLREAFSLRHTTENKP 434
++D L + A + EK +L TG + F + + EN
Sbjct: 167 IIDAVKLLNNENVAPFHSELTEKSSPEETLNELTGRLSNNHQCKFCSRHFCYKKSLEN-- 224
Query: 435 HSPKTPEPRRSPLGQKRG--MLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEK 492
H KT R LG+K G ML S S S + P K D ++ E+
Sbjct: 225 HLAKTH--RSLLLGKKHGLKMLERSFSARRSKRNRKCPVKF-----------DDTSDDEQ 271
Query: 493 DSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCH 552
+SG GS +++ E F + + S D GS+ + + E E D +SD++
Sbjct: 272 ESGDGSDNLNQENFDKEKSDRNDSE--------DPGSEYNAEEDELEEEMSDEYSDIEEQ 323
Query: 553 SNQE 556
S ++
Sbjct: 324 SEKD 327
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 34.3 bits (77), Expect = 0.51
Identities = 57/275 (20%), Positives = 95/275 (34%), Gaps = 47/275 (17%)
Query: 432 NKPHSPKTPEPRRSPLGQKR-GMLSSSTSGAISDKGVLRPQKEAVS---------SSH-- 479
N+ PK E + Q+R G +S + A S+ G + E +S S H
Sbjct: 1753 NRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHED 1812
Query: 480 ---------GPSDP--TDRAE-VEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDR 527
G DP +D AE +E G +SEG P+ + P
Sbjct: 1813 NLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESE 1872
Query: 528 GSQEHVDSQEKAPETDD-SFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEI-- 584
+ E PE++D + + E G + P+ A P T+ + E
Sbjct: 1873 DVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAE---APEAEKEAQPETESVEALETEG 1929
Query: 585 ----------LSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHH 634
++ + Q S+V + + ++ P + +L ++
Sbjct: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL-----EVEV 1984
Query: 635 EAQQSEGE--QNYRKFRAKICPGENQAAEDELRKE 667
E Q++EGE A GE Q AE+E + E
Sbjct: 1985 ETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPE 2019
>gi|24308382 leukocyte receptor cluster member 8 [Homo sapiens]
Length = 800
Score = 34.3 bits (77), Expect = 0.51
Identities = 34/151 (22%), Positives = 59/151 (39%), Gaps = 16/151 (10%)
Query: 407 RTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKG 466
RT + K+V +RL++ + +P T EP +KR +SS
Sbjct: 312 RTEKLLKEVLQARLQDGSAYTIDWSREPLPGLTREPVAESPKKKRWEAASS--------- 362
Query: 467 VLRPQKEAVSSSHGPSDPTDRAE-----VEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAA 521
L P + A S++ G P+ R + G+ T + + D S S++ +
Sbjct: 363 -LHPPRGAGSATRGGGAPSQRGTPGAGGAGRARGNSFTKFGNRNVFMKDNSSSSSTD-SR 420
Query: 522 SSPGDRGSQEHVDSQEKAPETDDSFSDVDCH 552
S R H + ++D S+S +CH
Sbjct: 421 SRSSSRSPTRHFRRSDSHSDSDSSYSGNECH 451
>gi|169173184 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1230
Score = 33.9 bits (76), Expect = 0.67
Identities = 30/84 (35%), Positives = 35/84 (41%), Gaps = 14/84 (16%)
Query: 454 LSSSTSGAI--SDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVD------SEG 505
+S S SGA SD G P VS+S T RA DSG S+S G
Sbjct: 233 ISPSASGASTSSDSGWASPSASWVSTS------TSRASTSSDSGWASSSASWDSITSDSG 286
Query: 506 FSIPDTGSHCSSEYAASSPGDRGS 529
+ P SS AS+P D GS
Sbjct: 287 WVCPSASWASSSASWASAPSDSGS 310
Score = 30.8 bits (68), Expect = 5.6
Identities = 29/94 (30%), Positives = 35/94 (37%), Gaps = 17/94 (18%)
Query: 452 GMLSSSTSGAI--SDKGVLRPQKEAVS---------SSHGPSDPTDRAEVEKDSGHGSTS 500
G S S SGA SD G P S S+ G S P+D + STS
Sbjct: 99 GWASPSASGASIPSDSGWASPSVSGASIPSAFWASPSASGASTPSDSGWASPSASWASTS 158
Query: 501 VD------SEGFSIPDTGSHCSSEYAASSPGDRG 528
D S ++ P SS AS+P D G
Sbjct: 159 SDSGWASPSASWTSPSASCASSSASGASTPSDSG 192
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,833,312
Number of Sequences: 37866
Number of extensions: 1511070
Number of successful extensions: 5423
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 5246
Number of HSP's gapped (non-prelim): 269
length of query: 862
length of database: 18,247,518
effective HSP length: 111
effective length of query: 751
effective length of database: 14,044,392
effective search space: 10547338392
effective search space used: 10547338392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.