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Search of human proteins with 4505757
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
(388 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 791 0.0
gi|119372302 pepsinogen 4, group I [Homo sapiens] 389 e-108
gi|119372298 pepsinogen 3, group I [Homo sapiens] 389 e-108
gi|23943854 pepsinogen 5, group I [Homo sapiens] 386 e-107
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 353 2e-97
gi|4503143 cathepsin D preproprotein [Homo sapiens] 289 3e-78
gi|4758754 napsin A preproprotein [Homo sapiens] 250 1e-66
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 248 5e-66
gi|4506475 renin preproprotein [Homo sapiens] 234 8e-62
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 123 3e-28
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 119 6e-27
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 119 6e-27
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 90 3e-18
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 90 3e-18
gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo s... 85 1e-16
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 74 3e-13
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 68 2e-11
gi|26667257 eyes absent 4 isoform d [Homo sapiens] 37 0.030
gi|98991763 eyes absent 4 isoform b [Homo sapiens] 37 0.030
gi|98991760 eyes absent 4 isoform a [Homo sapiens] 37 0.030
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 29 8.3
>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
Length = 388
Score = 791 bits (2043), Expect = 0.0
Identities = 388/388 (100%), Positives = 388/388 (100%)
Query: 1 MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLS 60
MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLS
Sbjct: 1 MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLS 60
Query: 61 VTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSES 120
VTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSES
Sbjct: 61 VTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSES 120
Query: 121 STYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIM 180
STYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIM
Sbjct: 121 STYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIM 180
Query: 181 GLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIY 240
GLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIY
Sbjct: 181 GLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIY 240
Query: 241 WAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQE 300
WAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQE
Sbjct: 241 WAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQE 300
Query: 301 DEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPL 360
DEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPL
Sbjct: 301 DEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPL 360
Query: 361 WILGDVFLRSYYSVYDLGNNRVGFATAA 388
WILGDVFLRSYYSVYDLGNNRVGFATAA
Sbjct: 361 WILGDVFLRSYYSVYDLGNNRVGFATAA 388
>gi|119372302 pepsinogen 4, group I [Homo sapiens]
Length = 388
Score = 389 bits (998), Expect = e-108
Identities = 197/392 (50%), Positives = 265/392 (67%), Gaps = 8/392 (2%)
Query: 1 MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYR---FG 57
MKW+++ L + L E + KVPL + KS+R T+ E+GLL +FL+ H +PA KY
Sbjct: 1 MKWLLL-LGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEA 59
Query: 58 DLSVTYEPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFN 116
V +P+ Y+D YFG I IGTP Q+F V+FDTGSSNLWVPSVYC S ACT+H+RFN
Sbjct: 60 PTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFN 119
Query: 117 PSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
P +SSTY + +T S+ YG+GS+TG GYDT+ V I NQ FGLSE EPG+ YA F
Sbjct: 120 PEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
Query: 177 DGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYT 236
DGI+GLAYP++S AT + +G ++ +FSVYLS SG V+FGG+DSS YT
Sbjct: 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLS-ADDQSGSVVIFGGIDSSYYT 238
Query: 237 GQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQAT 296
G + W PVT E YWQI ++ + G+A C+EGCQAIVDTGTSLLT P ++ +
Sbjct: 239 GSLNWVPVTVEGYWQITVDSITMNGEAIA-CAEGCQAIVDTGTSLLTGPTSPIANIQSDI 297
Query: 297 GAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQN 356
GA E+ G +V+C++I +LP + F INGV++P+PPS+YIL + G C G + L +++
Sbjct: 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTES 357
Query: 357 GQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
G+ LWILGDVF+R Y++V+D NN+VG A A
Sbjct: 358 GE-LWILGDVFIRQYFTVFDRANNQVGLAPVA 388
>gi|119372298 pepsinogen 3, group I [Homo sapiens]
Length = 388
Score = 389 bits (998), Expect = e-108
Identities = 197/392 (50%), Positives = 265/392 (67%), Gaps = 8/392 (2%)
Query: 1 MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYR---FG 57
MKW+++ L + L E + KVPL + KS+R T+ E+GLL +FL+ H +PA KY
Sbjct: 1 MKWLLL-LGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKA 59
Query: 58 DLSVTYEPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFN 116
V +P+ Y+D YFG I IGTP Q+F V+FDTGSSNLWVPSVYC S ACT+H+RFN
Sbjct: 60 PTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFN 119
Query: 117 PSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
P +SSTY + +T S+ YG+GS+TG GYDT+ V I NQ FGLSE EPG+ YA F
Sbjct: 120 PEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
Query: 177 DGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYT 236
DGI+GLAYP++S AT + +G ++ +FSVYLS SG V+FGG+DSS YT
Sbjct: 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLS-ADDQSGSVVIFGGIDSSYYT 238
Query: 237 GQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQAT 296
G + W PVT E YWQI ++ + G+A C+EGCQAIVDTGTSLLT P ++ +
Sbjct: 239 GSLNWVPVTVEGYWQITVDSITMNGEAIA-CAEGCQAIVDTGTSLLTGPTSPIANIQSDI 297
Query: 297 GAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQN 356
GA E+ G +V+C++I +LP + F INGV++P+PPS+YIL + G C G + L +++
Sbjct: 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTES 357
Query: 357 GQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
G+ LWILGDVF+R Y++V+D NN+VG A A
Sbjct: 358 GE-LWILGDVFIRQYFTVFDRANNQVGLAPVA 388
>gi|23943854 pepsinogen 5, group I [Homo sapiens]
Length = 388
Score = 386 bits (991), Expect = e-107
Identities = 195/392 (49%), Positives = 264/392 (67%), Gaps = 8/392 (2%)
Query: 1 MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYR---FG 57
MKW+++ L + L E + KVPL + KS+R T+ E+GLL +FL+ H +PA KY
Sbjct: 1 MKWLLL-LGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEA 59
Query: 58 DLSVTYEPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFN 116
V +P+ Y+D YFG I IGTP Q+F V+FDTGSSNLWVPSVYC S ACT+H+RFN
Sbjct: 60 PTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFN 119
Query: 117 PSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
P +SSTY + +T S+ YG+GS+TG GYDT+ V I NQ FGLSE EPG+ YA F
Sbjct: 120 PEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
Query: 177 DGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYT 236
DGI+GLAYP++S AT + +G ++ +FSVYLS SG V+FGG+DSS YT
Sbjct: 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLS-ADDKSGSVVIFGGIDSSYYT 238
Query: 237 GQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQAT 296
G + W PVT E YWQI ++ + G+ C+EGCQAIVDTGTSLLT P ++ +
Sbjct: 239 GSLNWVPVTVEGYWQITVDSITMNGETIA-CAEGCQAIVDTGTSLLTGPTSPIANIQSDI 297
Query: 297 GAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQN 356
GA E+ G +V+C++I +LP + F INGV++P+PPS+YIL + G C G + + +++
Sbjct: 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTES 357
Query: 357 GQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
G+ LWILGDVF+R Y++V+D NN+VG A A
Sbjct: 358 GE-LWILGDVFIRQYFTVFDRANNQVGLAPVA 388
>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
Length = 396
Score = 353 bits (905), Expect = 2e-97
Identities = 183/393 (46%), Positives = 259/393 (65%), Gaps = 12/393 (3%)
Query: 4 MVVVLVCLQLLEA--AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSV 61
++++LV L+L EA ++ +VPL++ S+++ ++ + L EF ++H D +
Sbjct: 5 LLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQ 64
Query: 62 TY-EPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSE 119
+ EP+ Y+D YFG ISIG+PPQNF V+FDTGSSNLWVPSVYC S AC +HSRF PS+
Sbjct: 65 SAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQ 124
Query: 120 SSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGI 179
SSTYS GQ+FS+QYG+GSL+G G D ++V+ + V Q+FG S EPG FV A+FDGI
Sbjct: 125 SSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGI 184
Query: 180 MGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYL-SNQQGSSGGAVVFGGVDSSLYTGQ 238
+GL YP+L+V T M+ + + P+FSVY+ SN +G +G ++FGG D S ++G
Sbjct: 185 LGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGS 244
Query: 239 IYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGA 298
+ W PVT++ YWQI ++ +GG +CSEGCQAIVDTGTSL+T P + L A GA
Sbjct: 245 LNWVPVTKQAYWQIALDNIQVGGTVM-FCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGA 303
Query: 299 QEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYIL----SNNGYCTVGVEPTYLSS 354
+ G++ V C ++ +P +TF INGV + L P++Y L +C+ G + +
Sbjct: 304 APVD-GEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHP 362
Query: 355 QNGQPLWILGDVFLRSYYSVYDLGNNRVGFATA 387
G PLWILGDVF+R +YSV+D GNNRVG A A
Sbjct: 363 PAG-PLWILGDVFIRQFYSVFDRGNNRVGLAPA 394
>gi|4503143 cathepsin D preproprotein [Homo sapiens]
Length = 412
Score = 289 bits (739), Expect = 3e-78
Identities = 166/408 (40%), Positives = 233/408 (57%), Gaps = 31/408 (7%)
Query: 6 VVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEP 65
+ L L +A+V++PL KF SIR TM E G E L P KY +VT P
Sbjct: 9 LALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAK--GPVSKYSQAVPAVTEGP 66
Query: 66 MA-----YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPS 118
+ YMDA Y+GEI IGTPPQ F V+FDTGSSNLWVPS++C+ AC H ++N
Sbjct: 67 IPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSD 126
Query: 119 ESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQ-----------SIQVPNQEFGLSENEP 167
+SSTY NG +F + YGSGSL+G+ DT++V ++V Q FG + +P
Sbjct: 127 KSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQP 186
Query: 168 GTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLS-NQQGSSGGAVV 226
G F+ A+FDGI+G+AYP +SV+ ++Q+ + +FS YLS + GG ++
Sbjct: 187 GITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELM 246
Query: 227 FGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASG--WCSEGCQAIVDTGTSLLTV 284
GG DS Y G + + VT++ YWQ+ +++ + ASG C EGC+AIVDTGTSL+
Sbjct: 247 LGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEV---ASGLTLCKEGCEAIVDTGTSLMVG 303
Query: 285 PQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYIL----SNN 340
P + L +A GA G++++ C + LP++T + G + L P Y L +
Sbjct: 304 PVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGK 363
Query: 341 GYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
C G + +G PLWILGDVF+ YY+V+D NNRVGFA AA
Sbjct: 364 TLCLSGFMGMDIPPPSG-PLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
>gi|4758754 napsin A preproprotein [Homo sapiens]
Length = 420
Score = 250 bits (639), Expect = 1e-66
Identities = 143/342 (41%), Positives = 198/342 (57%), Gaps = 13/342 (3%)
Query: 57 GDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSR 114
GD + Y D YFGEI +GTPPQNF V FDTGSSNLWVPS C S C H R
Sbjct: 62 GDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHR 121
Query: 115 FNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYA 174
F+P SS++ NG F++QYG+G + G D LT+ I+ + FG + EP F +A
Sbjct: 122 FDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFA 181
Query: 175 QFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLS-NQQGSSGGAVVFGGVDSS 233
FDGI+GL +P LSV+ M +V++G L PVFS YL+ + + GG +V GG D +
Sbjct: 182 HFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPA 241
Query: 234 LYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALL 293
Y + + PVT YWQI +E +G + C++GC AI+DTGTSL+T P + + AL
Sbjct: 242 HYIPPLTFVPVTVPAYWQIHMERVKVGPGLT-LCAKGCAAILDTGTSLITGPTEEIRALH 300
Query: 294 QATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYIL--SNNG--YCTVGVEP 349
A G G++++ C+ I LP+++F++ GV F L Y++ + NG C G +
Sbjct: 301 AAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQA 360
Query: 350 TYLSSQNGQPLWILGDVFLRSYYSVYDLG----NNRVGFATA 387
+ G P WILGDVFL +Y +V+D G + RVG A A
Sbjct: 361 LDVPPPAG-PFWILGDVFLGTYVAVFDRGDMKSSARVGLARA 401
>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
Length = 363
Score = 248 bits (634), Expect = 5e-66
Identities = 126/300 (42%), Positives = 190/300 (63%), Gaps = 5/300 (1%)
Query: 4 MVVVLVCLQLLEA--AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSV 61
++++LV L+L EA ++ +VPL++ S+++ ++ + L EF ++H D +
Sbjct: 5 LLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQ 64
Query: 62 TY-EPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSE 119
+ EP+ Y+D YFG ISIG+PPQNF V+FDTGSSNLWVPSVYC S AC +HSRF PS+
Sbjct: 65 SAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQ 124
Query: 120 SSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGI 179
SSTYS GQ+FS+QYG+GSL+G G D ++V+ + V Q+FG S EPG FV A+FDGI
Sbjct: 125 SSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGI 184
Query: 180 MGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYL-SNQQGSSGGAVVFGGVDSSLYTGQ 238
+GL YP+L+V T M+ + + P+FSVY+ SN +G +G ++FGG D S ++G
Sbjct: 185 LGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGS 244
Query: 239 IYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGA 298
+ W PVT++ YWQI ++ L C + ++ +P Y ++ ++ + A
Sbjct: 245 LNWVPVTKQAYWQIALDNMLWSVPTLTSCRMSPSPLTESPIPSAQLPTPYWTSWMECSSA 304
>gi|4506475 renin preproprotein [Homo sapiens]
Length = 406
Score = 234 bits (598), Expect = 8e-62
Identities = 132/377 (35%), Positives = 204/377 (54%), Gaps = 13/377 (3%)
Query: 20 KVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISI 79
++ LK+ SIRE++KE+G+ L P + G+ + + YMD Y+GEI I
Sbjct: 33 RIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGI 92
Query: 80 GTPPQNFLVLFDTGSSNLWVPSVYCQS--QACTSHSRFNPSESSTYSTNGQTFSLQYGSG 137
GTPPQ F V+FDTGSSN+WVPS C AC H F+ S+SS+Y NG +L+Y +G
Sbjct: 93 GTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTG 152
Query: 138 SLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQ 197
+++GF D +TV I V Q FG P F+ A+FDG++G+ + ++ T
Sbjct: 153 TVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFD 211
Query: 198 GMVQEGALTSPVFSVYL---SNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGI 254
++ +G L VFS Y S S GG +V GG D Y G ++ + + WQI +
Sbjct: 212 NIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQM 271
Query: 255 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 314
+ + G ++ C +GC A+VDTG S ++ + L++A GA++ + ++V CN
Sbjct: 272 KGVSV-GSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEGP 329
Query: 315 NLPSLTFIINGVEFPLPPSSYIL----SNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRS 370
LP ++F + G E+ L + Y+ S+ CT+ + + G P W LG F+R
Sbjct: 330 TLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTG-PTWALGATFIRK 388
Query: 371 YYSVYDLGNNRVGFATA 387
+Y+ +D NNR+GFA A
Sbjct: 389 FYTEFDRRNNRIGFALA 405
>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
[Homo sapiens]
Length = 468
Score = 123 bits (308), Expect = 3e-28
Identities = 99/332 (29%), Positives = 156/332 (46%), Gaps = 59/332 (17%)
Query: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSR----FNPSESSTYSTNGQ 128
Y+ E+ IGTPPQ +L DTGSSN V A T HS F+ SSTY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV--------AGTPHSYIDTYFDTERSSTYRSKGF 143
Query: 129 TFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYA--QFDGIMGLAYPA 186
+++Y GS TGF G D +T+ + ++ NF +++GI+GLAY
Sbjct: 144 DVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYAT 203
Query: 187 LSVDEAT--TAMQGMVQEGALTSPVFSVYLSNQ------QGSSGGAVVFGGVDSSLYTGQ 238
L+ ++ T +V + + + VFS+ + G++GG++V GG++ SLY G
Sbjct: 204 LAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGD 262
Query: 239 IYWAPVTQELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQA 295
I++ P+ +E Y+QI I + IGGQ+ C E +AIVD+GT+LL +PQ+ A+++A
Sbjct: 263 IWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEA 322
Query: 296 TGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQ 355
Y IQ + F + PS+ L
Sbjct: 323 VARASLLY---------IQPMMGAGLNYECYRFGISPSTNAL------------------ 355
Query: 356 NGQPLWILGDVFLRSYYSVYDLGNNRVGFATA 387
++G + +Y ++D RVGFA +
Sbjct: 356 ------VIGATVMEGFYVIFDRAQKRVGFAAS 381
>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
[Homo sapiens]
Length = 518
Score = 119 bits (297), Expect = 6e-27
Identities = 84/240 (35%), Positives = 131/240 (54%), Gaps = 26/240 (10%)
Query: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSR----FNPSESSTYSTNGQ 128
Y+ E+ IGTPPQ +L DTGSSN V A T HS F+ SSTY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV--------AGTPHSYIDTYFDTERSSTYRSKGF 143
Query: 129 TFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYA--QFDGIMGLAYPA 186
+++Y GS TGF G D +T+ + ++ NF +++GI+GLAY
Sbjct: 144 DVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYAT 203
Query: 187 LSVDEAT--TAMQGMVQEGALTSPVFSVYLSNQ------QGSSGGAVVFGGVDSSLYTGQ 238
L+ ++ T +V + + + VFS+ + G++GG++V GG++ SLY G
Sbjct: 204 LAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGD 262
Query: 239 IYWAPVTQELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQA 295
I++ P+ +E Y+QI I + IGGQ+ C E +AIVD+GT+LL +PQ+ A+++A
Sbjct: 263 IWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEA 322
>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
[Homo sapiens]
Length = 396
Score = 119 bits (297), Expect = 6e-27
Identities = 84/240 (35%), Positives = 131/240 (54%), Gaps = 26/240 (10%)
Query: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSR----FNPSESSTYSTNGQ 128
Y+ E+ IGTPPQ +L DTGSSN V A T HS F+ SSTY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV--------AGTPHSYIDTYFDTERSSTYRSKGF 143
Query: 129 TFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYA--QFDGIMGLAYPA 186
+++Y GS TGF G D +T+ + ++ NF +++GI+GLAY
Sbjct: 144 DVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYAT 203
Query: 187 LSVDEAT--TAMQGMVQEGALTSPVFSVYLSNQ------QGSSGGAVVFGGVDSSLYTGQ 238
L+ ++ T +V + + + VFS+ + G++GG++V GG++ SLY G
Sbjct: 204 LAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGD 262
Query: 239 IYWAPVTQELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQA 295
I++ P+ +E Y+QI I + IGGQ+ C E +AIVD+GT+LL +PQ+ A+++A
Sbjct: 263 IWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEA 322
>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
[Homo sapiens]
Length = 476
Score = 90.1 bits (222), Expect = 3e-18
Identities = 85/344 (24%), Positives = 150/344 (43%), Gaps = 52/344 (15%)
Query: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSL 132
Y+ E+++G+PPQ +L DTGSSN V + + H + SSTY + +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Query: 133 QYGSGSLTGFFGYDTLTVQ---SIQVPNQEFGLSENEP----GTNFVYAQFDGIMGLAYP 185
Y G G G D +++ ++ V ++E++ G+N+ +GI+GLAY
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNW-----EGILGLAYA 185
Query: 186 ALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVT 245
++ L F + S S GG+++ GG+D SLYTG +++ P+
Sbjct: 186 EIA---------------RLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIR 230
Query: 246 QELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQATGAQEDE 302
+E Y+++ I I GQ C E ++IVD+GT+ L +P++ A +++ A
Sbjct: 231 REWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASST 290
Query: 303 --------YGQFLV---------NCNSIQNLPSLTFIIN-GVEFPLPPSSYILSNNGYCT 344
G+ LV N + +L + + N + P Y+ T
Sbjct: 291 EKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVAT 350
Query: 345 VGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
+ + ++G V + +Y V+D R+GFA +A
Sbjct: 351 SQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 394
>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
[Homo sapiens]
Length = 501
Score = 90.1 bits (222), Expect = 3e-18
Identities = 88/355 (24%), Positives = 159/355 (44%), Gaps = 49/355 (13%)
Query: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSL 132
Y+ E+++G+PPQ +L DTGSSN V + + H + SSTY + +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Query: 133 QYGSGSLTGFFGYDTLTVQ---SIQVPNQEFGLSENEP----GTNFVYAQFDGIMGLAYP 185
Y G G G D +++ ++ V ++E++ G+N+ +GI+GLAY
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNW-----EGILGLAYA 185
Query: 186 ALSV--DEATTAMQGMVQEGALTSPVFSVYL---------SNQQGSSGGAVVFGGVDSSL 234
++ D +V++ + + +FS+ L S S GG+++ GG+D SL
Sbjct: 186 EIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSL 244
Query: 235 YTGQIYWAPVTQELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSA 291
YTG +++ P+ +E Y+++ I I GQ C E ++IVD+GT+ L +P++ A
Sbjct: 245 YTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEA 304
Query: 292 LLQATGAQEDE--------YGQFLV---------NCNSIQNLPSLTFIIN-GVEFPLPPS 333
+++ A G+ LV N + +L + + N + P
Sbjct: 305 AVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQ 364
Query: 334 SYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
Y+ T + + ++G V + +Y V+D R+GFA +A
Sbjct: 365 QYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 419
>gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo
sapiens]
Length = 87
Score = 85.1 bits (209), Expect = 1e-16
Identities = 38/71 (53%), Positives = 53/71 (74%)
Query: 267 CSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGV 326
C+EGCQAIVDTGTSLLT P ++ + GA E+ G +V+C++I +LP + F INGV
Sbjct: 8 CAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGV 67
Query: 327 EFPLPPSSYIL 337
++P+PPS+YIL
Sbjct: 68 QYPVPPSAYIL 78
>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
[Homo sapiens]
Length = 457
Score = 73.6 bits (179), Expect = 3e-13
Identities = 83/338 (24%), Positives = 140/338 (41%), Gaps = 59/338 (17%)
Query: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSL 132
Y+ E+++G+PPQ +L DTGSSN V + + H + SSTY + +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Query: 133 QYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAY-PALSVDE 191
Y G G G D +P+ EP FD ++ + P L
Sbjct: 131 PYTQGKWEGELGTD--------LPDDSL-----EPF-------FDSLVKQTHVPNLF--- 167
Query: 192 ATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQ 251
++Q L F + S S GG+++ GG+D SLYTG +++ P+ +E Y++
Sbjct: 168 ---SLQ-------LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYE 217
Query: 252 IGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQATGAQEDE------ 302
+ I I GQ C E ++IVD+GT+ L +P++ A +++ A
Sbjct: 218 VIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDG 277
Query: 303 --YGQFLV---------NCNSIQNLPSLTFIIN-GVEFPLPPSSYILSNNGYCTVGVEPT 350
G+ LV N + +L + + N + P Y+ T +
Sbjct: 278 FWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCY 337
Query: 351 YLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
+ ++G V + +Y V+D R+GFA +A
Sbjct: 338 KFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 375
>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
[Homo sapiens]
Length = 432
Score = 67.8 bits (164), Expect = 2e-11
Identities = 80/337 (23%), Positives = 133/337 (39%), Gaps = 82/337 (24%)
Query: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSL 132
Y+ E+++G+PPQ +L DTGSSN V + + H + SSTY L
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYR------DL 124
Query: 133 QYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEA 192
+ G + VP + G E E GT D + G +P
Sbjct: 125 RKG-----------------VYVPYTQ-GKWEGELGT-------DLLCGAGFP------- 152
Query: 193 TTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQI 252
+ S S GG+++ GG+D SLYTG +++ P+ +E Y+++
Sbjct: 153 -------------------LNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEV 193
Query: 253 GIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQATGAQEDE------- 302
I I GQ C E ++IVD+GT+ L +P++ A +++ A
Sbjct: 194 IIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGF 253
Query: 303 -YGQFLV---------NCNSIQNLPSLTFIIN-GVEFPLPPSSYILSNNGYCTVGVEPTY 351
G+ LV N + +L + + N + P Y+ T +
Sbjct: 254 WLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK 313
Query: 352 LSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
+ ++G V + +Y V+D R+GFA +A
Sbjct: 314 FAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 350
>gi|26667257 eyes absent 4 isoform d [Homo sapiens]
Length = 639
Score = 37.0 bits (84), Expect = 0.030
Identities = 40/156 (25%), Positives = 57/156 (36%), Gaps = 4/156 (2%)
Query: 50 PAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQAC 109
PA K G LS T P+ +Y S P Q GSS ++Y +
Sbjct: 200 PAIKTESG-LSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVS 258
Query: 110 TSHSRFNPSESS--TYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEP 167
S + F+ S+ +Y+ GQ QY S S G + T + L E+ P
Sbjct: 259 NS-TNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTPSSTSTYQLQESLP 317
Query: 168 GTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEG 203
G +FD + + P +DE T G G
Sbjct: 318 GLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRG 353
>gi|98991763 eyes absent 4 isoform b [Homo sapiens]
Length = 616
Score = 37.0 bits (84), Expect = 0.030
Identities = 40/156 (25%), Positives = 57/156 (36%), Gaps = 4/156 (2%)
Query: 50 PAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQAC 109
PA K G LS T P+ +Y S P Q GSS ++Y +
Sbjct: 177 PAIKTESG-LSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVS 235
Query: 110 TSHSRFNPSESS--TYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEP 167
S + F+ S+ +Y+ GQ QY S S G + T + L E+ P
Sbjct: 236 NS-TNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTPSSTSTYQLQESLP 294
Query: 168 GTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEG 203
G +FD + + P +DE T G G
Sbjct: 295 GLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRG 330
>gi|98991760 eyes absent 4 isoform a [Homo sapiens]
Length = 639
Score = 37.0 bits (84), Expect = 0.030
Identities = 40/156 (25%), Positives = 57/156 (36%), Gaps = 4/156 (2%)
Query: 50 PAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQAC 109
PA K G LS T P+ +Y S P Q GSS ++Y +
Sbjct: 200 PAIKTESG-LSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVS 258
Query: 110 TSHSRFNPSESS--TYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEP 167
S + F+ S+ +Y+ GQ QY S S G + T + L E+ P
Sbjct: 259 NS-TNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTPSSTSTYQLQESLP 317
Query: 168 GTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEG 203
G +FD + + P +DE T G G
Sbjct: 318 GLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRG 353
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 28.9 bits (63), Expect = 8.3
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 5/56 (8%)
Query: 195 AMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYW 250
A Q + ++TS V ++Y + GS AV F + +G+I+W+ TQ W
Sbjct: 1441 ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSI-----SGRIFWSDATQGKTW 1491
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,740,181
Number of Sequences: 37866
Number of extensions: 655297
Number of successful extensions: 1454
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1370
Number of HSP's gapped (non-prelim): 29
length of query: 388
length of database: 18,247,518
effective HSP length: 104
effective length of query: 284
effective length of database: 14,309,454
effective search space: 4063884936
effective search space used: 4063884936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.