Guide to the Human Genome
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Search of human proteins with 4505577

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
         (969 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505577 paired basic amino acid cleaving system 4 isoform a p...  2066   0.0  
gi|20336180 paired basic amino acid cleaving system 4 isoform b ...  2031   0.0  
gi|20336182 paired basic amino acid cleaving system 4 isoform g ...  1915   0.0  
gi|20336184 paired basic amino acid cleaving system 4 isoform h ...  1880   0.0  
gi|20336188 paired basic amino acid cleaving system 4 isoform e ...  1294   0.0  
gi|27894285 paired basic amino acid cleaving system 4 isoform f ...  1294   0.0  
gi|20336190 paired basic amino acid cleaving system 4 isoform d ...  1294   0.0  
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro...  1092   0.0  
gi|20336186 paired basic amino acid cleaving system 4 isoform c ...   992   0.0  
gi|4505579 furin preproprotein [Homo sapiens]                         668   0.0  
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ...   607   e-173
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro...   600   e-171
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ...   504   e-142
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro...   462   e-130
gi|239755070 PREDICTED: similar to proprotein convertase subtili...   141   3e-33
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ...   141   3e-33
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ...   141   3e-33
gi|108773804 Fraser syndrome 1 [Homo sapiens]                         129   2e-29
gi|116734855 cysteine-rich with EGF-like domains 1 isoform 3 [Ho...    68   5e-11
gi|72534728 cysteine-rich with EGF-like domains 1 isoform 1 [Hom...    68   5e-11
gi|22095397 cysteine-rich with EGF-like domains 1 isoform 2 [Hom...    68   5e-11
gi|18490982 R-spondin 3 [Homo sapiens]                                 65   4e-10
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]                  63   2e-09
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo...    62   3e-09
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo...    62   3e-09
gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo...    62   3e-09
gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo...    62   3e-09
gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Ho...    61   4e-09
gi|29725609 epidermal growth factor receptor isoform a precursor...    61   6e-09
gi|41327736 epidermal growth factor receptor isoform d precursor...    61   6e-09

>gi|4505577 paired basic amino acid cleaving system 4 isoform a
           preproprotein [Homo sapiens]
          Length = 969

 Score = 2066 bits (5352), Expect = 0.0
 Identities = 969/969 (100%), Positives = 969/969 (100%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480

Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
           VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540

Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
           HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600

Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
           QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660

Query: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720
           KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL
Sbjct: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720

Query: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780
           GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
Sbjct: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780

Query: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840
           VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
Sbjct: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840

Query: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900
           ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
Sbjct: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900

Query: 901 CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF 960
           CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF
Sbjct: 901 CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF 960

Query: 961 CCRTCLLAG 969
           CCRTCLLAG
Sbjct: 961 CCRTCLLAG 969


>gi|20336180 paired basic amino acid cleaving system 4 isoform b
           preproprotein [Homo sapiens]
          Length = 956

 Score = 2031 bits (5261), Expect = 0.0
 Identities = 955/969 (98%), Positives = 955/969 (98%), Gaps = 13/969 (1%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480

Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
           VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540

Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
           HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600

Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
           QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660

Query: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720
           KAALSPSQVEVPEDEEDY             T VCHPECGDKGCDGPNADQCLNCVHFSL
Sbjct: 661 KAALSPSQVEVPEDEEDY-------------TGVCHPECGDKGCDGPNADQCLNCVHFSL 707

Query: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780
           GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
Sbjct: 708 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 767

Query: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840
           VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
Sbjct: 768 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 827

Query: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900
           ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
Sbjct: 828 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 887

Query: 901 CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF 960
           CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF
Sbjct: 888 CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF 947

Query: 961 CCRTCLLAG 969
           CCRTCLLAG
Sbjct: 948 CCRTCLLAG 956


>gi|20336182 paired basic amino acid cleaving system 4 isoform g
           preproprotein [Homo sapiens]
          Length = 975

 Score = 1915 bits (4960), Expect = 0.0
 Identities = 900/900 (100%), Positives = 900/900 (100%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480

Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
           VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540

Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
           HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600

Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
           QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660

Query: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720
           KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL
Sbjct: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720

Query: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780
           GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
Sbjct: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780

Query: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840
           VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
Sbjct: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840

Query: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900
           ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
Sbjct: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 47/140 (33%), Positives = 61/140 (43%), Gaps = 14/140 (10%)

Query: 800 CHPSC-KKCVDEP--EKCTVCKEGFSLAR----GSCIPDCEPGTYFDSELIRCGECHHTC 852
           CHP C  K  D P  ++C  C   FSL        C+  C  G + D+   RC  CH  C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVH-FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGC 753

Query: 853 GTCVGPGREECIHCAKNFHFHDWK--CVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG 910
            TC      +C+ C + F+ H     CV  C  GFY +E      K C +C  +C  C  
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES----QKNCLKCHPSCKKCVD 809

Query: 911 SSRNCSRCKTGFTQLGTSCI 930
               C+ CK GF+    SCI
Sbjct: 810 EPEKCTVCKEGFSLARGSCI 829


>gi|20336184 paired basic amino acid cleaving system 4 isoform h
           preproprotein [Homo sapiens]
          Length = 962

 Score = 1880 bits (4869), Expect = 0.0
 Identities = 886/900 (98%), Positives = 886/900 (98%), Gaps = 13/900 (1%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480

Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
           VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540

Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
           HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600

Query: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660
           QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP 660

Query: 661 KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL 720
           KAALSPSQVEVPEDEEDY             T VCHPECGDKGCDGPNADQCLNCVHFSL
Sbjct: 661 KAALSPSQVEVPEDEEDY-------------TGVCHPECGDKGCDGPNADQCLNCVHFSL 707

Query: 721 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 780
           GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
Sbjct: 708 GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC 767

Query: 781 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 840
           VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
Sbjct: 768 VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS 827

Query: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 900
           ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
Sbjct: 828 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR 887



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 47/140 (33%), Positives = 61/140 (43%), Gaps = 14/140 (10%)

Query: 800 CHPSC-KKCVDEP--EKCTVCKEGFSLAR----GSCIPDCEPGTYFDSELIRCGECHHTC 852
           CHP C  K  D P  ++C  C   FSL        C+  C  G + D+   RC  CH  C
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVH-FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGC 740

Query: 853 GTCVGPGREECIHCAKNFHFHDWK--CVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG 910
            TC      +C+ C + F+ H     CV  C  GFY +E      K C +C  +C  C  
Sbjct: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADES----QKNCLKCHPSCKKCVD 796

Query: 911 SSRNCSRCKTGFTQLGTSCI 930
               C+ CK GF+    SCI
Sbjct: 797 EPEKCTVCKEGFSLARGSCI 816


>gi|20336188 paired basic amino acid cleaving system 4 isoform e
           preproprotein [Homo sapiens]
          Length = 623

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 621/622 (99%), Positives = 621/622 (99%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480

Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
           VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540

Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
           HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600

Query: 601 QWTLEIQDLPSQVRNPEKQGKL 622
           QWTLEIQDLPSQVRNPEKQG L
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGNL 622


>gi|27894285 paired basic amino acid cleaving system 4 isoform f
           preproprotein [Homo sapiens]
          Length = 664

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 621/623 (99%), Positives = 622/623 (99%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480

Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
           VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540

Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
           HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600

Query: 601 QWTLEIQDLPSQVRNPEKQGKLK 623
           QWTLEIQDLPSQVRNPEKQG L+
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGDLE 623


>gi|20336190 paired basic amino acid cleaving system 4 isoform d
           preproprotein [Homo sapiens]
          Length = 652

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 621/623 (99%), Positives = 622/623 (99%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL 480

Query: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540
           VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
Sbjct: 481 VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE 540

Query: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600
           HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
Sbjct: 541 HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG 600

Query: 601 QWTLEIQDLPSQVRNPEKQGKLK 623
           QWTLEIQDLPSQVRNPEKQG L+
Sbjct: 601 QWTLEIQDLPSQVRNPEKQGDLE 623


>gi|20336246 proprotein convertase subtilisin/kexin type 5
           preproprotein [Homo sapiens]
          Length = 913

 Score = 1092 bits (2824), Expect = 0.0
 Identities = 524/942 (55%), Positives = 654/942 (69%), Gaps = 40/942 (4%)

Query: 38  GPGFRPLAPRPWRWLLLLALPAACSAPPPRP-VYTNHWAVQVLGGPAEADRVAAAHGYLN 96
           G G R   P     L +LAL   C  P  R  VYTNHWAV++ GG  EA+R+A+ +G++N
Sbjct: 2   GWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFIN 61

Query: 97  LGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVR-SDP 155
           +GQIG L+DYYHFYHS+T KRS +SSRG H+F+ M+P+V+W+QQQ VK+R KR    S  
Sbjct: 62  IGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRA 121

Query: 156 QALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL 215
           Q+ YFNDP W +MWY+HC D    C+S+MN++ AWKRGYTGKN+VVTILDDGIER HPDL
Sbjct: 122 QSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDL 181

Query: 216 APNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGG 275
             NYD+ AS DVNGND DP PRYDASNENKHGTRCAGEVAA+ANNS+C VGIA+NAKIGG
Sbjct: 182 MQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGG 241

Query: 276 IRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQ 335
           +RMLDGDVTD+VEAKS+   P ++ IYSASWGPDDDGKTVDGP  L +QAFE G++ GR+
Sbjct: 242 VRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRR 301

Query: 336 GLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSS 395
           GLGS+FVWASGNGGR  D+CSCDGYTNSIYTIS+SS  E+G KPWYLEEC+STLATTYSS
Sbjct: 302 GLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSS 361

Query: 396 GAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRP 455
           G  Y++KI+TTDLRQRCTD HTGTS SAPM AGIIALALEAN  LTWRDVQH++V+TSR 
Sbjct: 362 GESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRA 421

Query: 456 AHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPL 515
            HL A+DWK N AG KVSH YGFGL+DAEA+V+EA+KWT VP QH+CV ++D++ ++I  
Sbjct: 422 GHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRP 481

Query: 516 VQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRL 575
              +R+    S C+++ ++ V YLEHVVVR +I+HPRRGDL IYL SPSGT+SQLLA RL
Sbjct: 482 NSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRL 541

Query: 576 LDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEH 635
            D S EGF NWEFMT+HCWGE+A G W LE+ D PSQ+RN +  GKLKEWSL+LYGT+  
Sbjct: 542 FDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ 601

Query: 636 PYHTFSAHQSRSRMLELSAPELEPPKA-ALSPSQVEVPEDEEDYTAQSTPGSANILQTSV 694
           PY                +P  E PK      S+VE P D  DY  +   G         
Sbjct: 602 PY----------------SPTNEFPKVERFRYSRVEDPTD--DYGTEDYAGP-------- 635

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           C PEC + GCDGP  D C +C+H+       +R CVS CP G++     +RCR+C   CE
Sbjct: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCE 694

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 814
           +C      QC+SC+ G++ ++E N+CVT CP G Y D  +  C KC  +CK C  E   C
Sbjct: 695 SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT-EFHNC 753

Query: 815 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 874
           T C++G SL    C   CE G YF+ +   C  CH  C TC G G + CI+C + +   D
Sbjct: 754 TECRDGLSLQGSRCSVSCEDGRYFNGQ--DCQPCHRFCATCAGAGADGCINCTEGYFMED 811

Query: 875 WKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSS-RNCSRCKTGF------TQLGT 927
            +CV +C   +Y +      +K C++CD +CL+C G   +NC+ C +G+       Q+G 
Sbjct: 812 GRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGA 871

Query: 928 SCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG 969
            C      S A+  FC +VK N LC+RK+  Q CC+TC   G
Sbjct: 872 ICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG 913


>gi|20336186 paired basic amino acid cleaving system 4 isoform c
           preproprotein [Homo sapiens]
          Length = 487

 Score =  992 bits (2564), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60
           MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
Sbjct: 1   MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA 60

Query: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120
           CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
Sbjct: 61  CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL 120

Query: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180
           SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
Sbjct: 121 SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC 180

Query: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240
           RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
Sbjct: 181 RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA 240

Query: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300
           SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
Sbjct: 241 SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID 300

Query: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360
           IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
Sbjct: 301 IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY 360

Query: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420
           TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
Sbjct: 361 TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS 420

Query: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHK 471
           VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHK
Sbjct: 421 VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHK 471


>gi|4505579 furin preproprotein [Homo sapiens]
          Length = 794

 Score =  668 bits (1723), Expect = 0.0
 Identities = 362/724 (50%), Positives = 451/724 (62%), Gaps = 68/724 (9%)

Query: 47  RPWRWLLLLA---LPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNL 103
           RPW   ++ A   L    +    + V+TN WAV++ GGPA A+ VA  HG+LNLGQI   
Sbjct: 4   RPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--F 61

Query: 104 EDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDP 163
            DYYHF+H    KRS    R  H+ L+ +PQV+WL+QQ  KRR KR V  +P      DP
Sbjct: 62  GDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEP-----TDP 116

Query: 164 IWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYA 223
            +   WYL     +   + ++NV+AAW +GYTG  +VV+ILDDGIE+NHPDLA NYD  A
Sbjct: 117 KFPQQWYL-----SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171

Query: 224 SYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDV 283
           S+DVN  D DP PRY   N+N+HGTRCAGEVAA ANN  C VG+AYNA+IGG+RMLDG+V
Sbjct: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231

Query: 284 TDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343
           TD VEA+SLG+ PN+I IYSASWGP+DDGKTVDGP RLA++AF  G+ +GR GLGSIFVW
Sbjct: 232 TDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291

Query: 344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKI 403
           ASGNGGRE D C+CDGYTNSIYT+S+SSAT+ G  PWY E C+STLATTYSSG   E++I
Sbjct: 292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQI 351

Query: 404 VTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDW 463
           VTTDLRQ+CT+ HTGTS SAP+ AGIIAL LEAN  LTWRD+QHL+V+TS+PAHL A+DW
Sbjct: 352 VTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDW 411

Query: 464 KVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTA 523
             NG G KVSH YG+GL+DA A+V  A+ WT V  Q  C+      P+ I     +R T 
Sbjct: 412 ATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKT- 470

Query: 524 LTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGF 583
             +AC    +  +  LEH   R ++S+ RRGDL I+LVSP GT+S LLA R  D S +GF
Sbjct: 471 -VTACLGEPN-HITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528

Query: 584 TNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAH 643
            +W FMT H W E   G+W LEI++  S+  N    G L +++L+LYGT           
Sbjct: 529 NDWAFMTTHSWDEDPSGEWVLEIEN-TSEANN---YGTLTKFTLVLYGT----------- 573

Query: 644 QSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKG 703
                     APE  P            PE     T  S+       +    H +   + 
Sbjct: 574 ----------APEGLPVP----------PESSGCKTLTSSQACVVCEEGFSLHQKSCVQH 613

Query: 704 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 763
           C    A Q L+  + +   V+T R  V               C  CH  C TC   A T 
Sbjct: 614 CPPGFAPQVLDTHYSTENDVETIRASV---------------CAPCHASCATCQGPALTD 658

Query: 764 CLSC 767
           CLSC
Sbjct: 659 CLSC 662



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 14/75 (18%)

Query: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPG-----------TYFDSELIR---CGECHHT 851
           K +   + C VC+EGFSL + SC+  C PG           T  D E IR   C  CH +
Sbjct: 588 KTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHAS 647

Query: 852 CGTCVGPGREECIHC 866
           C TC GP   +C+ C
Sbjct: 648 CATCQGPALTDCLSC 662



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 18/70 (25%)

Query: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF--------YADESQKN------C 797
           GC+T +S  A  C+ C  GF  HQ+  +CV  CP GF        Y+ E+         C
Sbjct: 586 GCKTLTSSQA--CVVCEEGFSLHQK--SCVQHCPPGFAPQVLDTHYSTENDVETIRASVC 641

Query: 798 LKCHPSCKKC 807
             CH SC  C
Sbjct: 642 APCHASCATC 651



 Score = 37.4 bits (85), Expect = 0.069
 Identities = 18/69 (26%), Positives = 29/69 (42%), Gaps = 11/69 (15%)

Query: 861 EECIHCAKNFHFHDWKCVPACGEGFYPE----------EMPGLPHKVCRRCDENCLSCAG 910
           + C+ C + F  H   CV  C  GF P+          ++  +   VC  C  +C +C G
Sbjct: 594 QACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQG 653

Query: 911 SS-RNCSRC 918
            +  +C  C
Sbjct: 654 PALTDCLSC 662


>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
           sapiens]
          Length = 755

 Score =  607 bits (1565), Expect = e-173
 Identities = 336/758 (44%), Positives = 442/758 (58%), Gaps = 93/758 (12%)

Query: 42  RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
           RP     W R +L LAL  P A    P R P+Y + WAVQV  G  E +R+A   G++NL
Sbjct: 2   RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61

Query: 98  GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
           G I     Y+H  H    ++S     G    L+ +P+V+W QQQ ++RRVKR V      
Sbjct: 62  GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115

Query: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
           +   DP +S  WY+     NS  + ++++  AW +G +G+ +VV++LDDGIE++HPDL  
Sbjct: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170

Query: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
           NYD  ASYD N  D DP PRY  S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230

Query: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
           MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF  G+ KGR GL
Sbjct: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290

Query: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
           G++F+WASGNGG   D C+CDGYTNSI+T+SV S T+ G  PWY E CASTL TTYSSG 
Sbjct: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350

Query: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
             + +IVTTDL   CTD HTGTS SAP+ AG+IALALEAN  LTWRD+QHL+V+ S+PAH
Sbjct: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410

Query: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
           L+A DW+ NG G +VSH YG+GL+DA  LV  A+ W     Q  C      RP   P++ 
Sbjct: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468

Query: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
           ++      SACA  H+  R   LEHV  + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526

Query: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHP 636
           D+S EG+ NW FM+ H W E  +G WTL +++           G L  ++L+LYGTAE  
Sbjct: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNT----GTLYRYTLLLYGTAE-- 580

Query: 637 YHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCH 696
                         +++A     P      S   V  D E                 +C 
Sbjct: 581 --------------DMTA----RPTGPQVTSSACVQRDTE----------------GLC- 605

Query: 697 PECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDT-------------AA 743
                + CDGP          + LG +     C++ CP  +F  T             A 
Sbjct: 606 -----QACDGP---------AYILGQL-----CLAYCPPRFFNHTRLVTAGPGHTAAPAL 646

Query: 744 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCV 781
           R C  CH  C TC   +   C SC       Q+  +C+
Sbjct: 647 RVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684



 Score = 38.9 bits (89), Expect = 0.024
 Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 15/108 (13%)

Query: 753 CETCSSRA---ATQCLS-CRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKC- 807
           C+ C   A      CL+ C   F++H  +   VT  P G  A  + + C  CH SC  C 
Sbjct: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRL---VTAGP-GHTAAPALRVCSSCHASCYTCR 660

Query: 808 VDEPEKCTVCKEGFSL--ARGSCIPDCEPGTYFDSELIRCGEC-HHTC 852
              P  CT C    +L   +GSC+    P T      +R   C HH C
Sbjct: 661 GGSPRDCTSCPPSSTLDQQQGSCM---GPTTPDSRPRLRAAACPHHRC 705


>gi|20336242 proprotein convertase subtilisin/kexin type 1
           preproprotein [Homo sapiens]
          Length = 753

 Score =  600 bits (1548), Expect = e-171
 Identities = 305/593 (51%), Positives = 397/593 (66%), Gaps = 10/593 (1%)

Query: 51  WLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFY 110
           ++L  A  A  SA   R  + N WA ++ GGP  A  +A   GY  LGQIG+LE++Y F 
Sbjct: 13  FVLFCAWCALNSAKAKRQ-FVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFK 71

Query: 111 HSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWY 170
           H    +RS  S+      L  D +V W +QQ  K R KR    D     FNDP+W+  WY
Sbjct: 72  HKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWY 131

Query: 171 LHCGDKNSRC-RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNG 229
           L      +   + +++V   W++G TGK VV+T+LDDG+E NH D+  NYD  ASYD N 
Sbjct: 132 LQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFND 191

Query: 230 NDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEA 289
           ND+DP PRYD +NENKHGTRCAGE+A  ANN  C VG+AYN+K+GGIRMLDG VTD +EA
Sbjct: 192 NDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEA 251

Query: 290 KSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGG 349
            S+G  P ++DIYSASWGP+DDGKTV+GPGRLA++AFEYG+K+GRQG GSIFVWASGNGG
Sbjct: 252 SSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGG 311

Query: 350 REGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLR 409
           R+GD C CDGYT+SIYTIS+SSA++ G  PWY E+C+STLAT+YSSG + +++I + DL 
Sbjct: 312 RQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLH 371

Query: 410 QRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKAS-DWKVNGA 468
             CT+ HTGTS SAP+ AGI ALALEAN  LTWRD+QHL+V TS    L  +  WK NGA
Sbjct: 372 NDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGA 431

Query: 469 GHKVSHFYGFGLVDAEALV--VEAKKWTAVPSQHMCVAA-SDKRPRSIPLVQVLRTTALT 525
           G  V+  +GFGL++A+ALV   + + W +VP +  CV   +D  PR++     +     T
Sbjct: 432 GLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPT 491

Query: 526 SACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTN 585
            AC E  +  +  LEHV    +I + RRGDL + L S +GT + LLA+R  D S  GF N
Sbjct: 492 RAC-EGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKN 550

Query: 586 WEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYH 638
           W+FM+VH WGE   G WTL I D+  +++N   +G++  W LIL+GT+  P H
Sbjct: 551 WDFMSVHTWGENPIGTWTLRITDMSGRIQN---EGRIVNWKLILHGTSSQPEH 600


>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
           sapiens]
          Length = 638

 Score =  504 bits (1298), Expect = e-142
 Identities = 284/605 (46%), Positives = 371/605 (61%), Gaps = 16/605 (2%)

Query: 63  APPPRPVYTNHWAVQV-LGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLS 121
           A   RPV+TNH+ V++  GG  +A +VAA HG+  + ++   E  YHFYH+   K     
Sbjct: 23  ASAERPVFTNHFLVELHKGGEDKARQVAAEHGF-GVRKLPFAEGLYHFYHNGLAKAKRRR 81

Query: 122 SRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA-LYFNDPIWSNMWYL-HCGDKNSR 179
           S      L  DP+VK   QQE   R KR  R   +  +  NDP+++  WYL + G  +  
Sbjct: 82  SLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGT 141

Query: 180 CRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD 239
              ++NV  AW+ GYTGK V + I+DDGI+  HPDLA NY++ ASYD + ND  P PRY 
Sbjct: 142 PGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYT 201

Query: 240 ASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGD-VTDVVEAKSLGIRPNY 298
               N HGTRCAGEV+A+ANN+ C VG+AYN+K+ GIRMLD   +TD++EA S+   P  
Sbjct: 202 DDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQL 261

Query: 299 IDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCD 358
           IDIYSASWGP D+GKTVDGP  L  QA   G+ KGR G GSI+VWASG+GG   D C+CD
Sbjct: 262 IDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDD-CNCD 320

Query: 359 GYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFY--ERKIVTTDLRQRCTDGH 416
           GY +S++TIS++SA  +G    Y E C+STLA+T+S+G     E  + TTDL   CT  H
Sbjct: 321 GYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRH 380

Query: 417 TGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSR--PAHLKASDWKVNGAGHKVSH 474
           +GTS +AP  AG+ ALALEAN  LTWRD+QHL V TS+    H +   W+ NG G + +H
Sbjct: 381 SGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNH 440

Query: 475 FYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQ 534
            +G+G++DA A+V  AK W  VP +  CV  S + P  IP    L  T  T AC E  + 
Sbjct: 441 LFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDAC-EGKEN 499

Query: 535 RVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL-DLSNEGFTNWEFMTVHC 593
            V YLEHV    +++  RRGDL I + SP GTKS LL++R   D S  GF  W FMT H 
Sbjct: 500 FVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHT 559

Query: 594 WGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELS 653
           WGE A G WTLE+      V +  ++G LKEW+L+L+GT   PY        +S++    
Sbjct: 560 WGEDARGTWTLEL----GFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSK 615

Query: 654 APELE 658
             ELE
Sbjct: 616 KEELE 620


>gi|20336248 proprotein convertase subtilisin/kexin type 7
           preproprotein [Homo sapiens]
          Length = 785

 Score =  462 bits (1188), Expect = e-130
 Identities = 263/622 (42%), Positives = 354/622 (56%), Gaps = 31/622 (4%)

Query: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131

Query: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181

Query: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241

Query: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301

Query: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361

Query: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421

Query: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481

Query: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541

Query: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+  +   
Sbjct: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598

Query: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673
             + G L++W L LYG+           + R R+LE  +S   L    A   P  +++PE
Sbjct: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654

Query: 674 DEEDYTAQSTPGSANILQTSVC 695
            E+ YT   TP +   L    C
Sbjct: 655 -EDGYTI--TPNTLKTLVLVGC 673


>gi|239755070 PREDICTED: similar to proprotein convertase
           subtilisin/kexin type 5 [Homo sapiens]
          Length = 853

 Score =  141 bits (355), Expect = 3e-33
 Identities = 85/275 (30%), Positives = 119/275 (43%), Gaps = 25/275 (9%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH +C +  C GP AD C  C+  S   V     C+  CP G + +   + CR CHK C 
Sbjct: 364 CHKDCLE--CSGPKADDCELCLESSW--VLYDGLCLEECPAGTYYEKQTKECRDCHKSCL 419

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVT--LCPAGFYADESQKNCLKCHPSCKKCVDEPE 812
           TCSS     C +C++G   +    +C+    C    Y DE    C  CH  C  C+   E
Sbjct: 420 TCSSSGT--CTTCQKGLIMNPR-GSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAE 476

Query: 813 -KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 871
            +C  C     L   +C+ DC  G Y D +  RC  CH +C TC G    +C  C   + 
Sbjct: 477 DQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 536

Query: 872 FHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRCKTGFTQLGTSCI 930
               +C+  C EG+Y +   G     C RC+ +C  C G    +C  C   F  L +   
Sbjct: 537 QLGKECLLQCREGYYADNSTGR----CERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGE 592

Query: 931 TNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTC 965
            + +C   D  + E  +S + CER      C  TC
Sbjct: 593 CHRSC--PDHYYVE--QSTQTCER------CHPTC 617



 Score =  131 bits (330), Expect = 3e-30
 Identities = 66/226 (29%), Positives = 100/226 (44%), Gaps = 23/226 (10%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH  C  + C+G ++ QC +C     G  +  ++C+  C  GY+ D +  RC RC++ C+
Sbjct: 513 CHSSC--RTCEGRHSRQCHSC---RPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE-K 813
            C     T CLSC R F+  +    C   CP  +Y ++S + C +CHP+C +C  +    
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627

Query: 814 CTVCKEGFSLARGSCIPDCEPGTY--FDSELIRCGECHHTCGTCVGPGREECIHCAKN-- 869
           C  C   + L  G C  DC  G Y   + E   C +CH +C  C GPG + C  C  N  
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLV 687

Query: 870 FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNC 915
            H  +  C+  C     P               + C  C  ++  C
Sbjct: 688 LHMDESHCLHCCNTSDPPSA-------------QECCDCQDTTDEC 720



 Score =  117 bits (292), Expect = 7e-26
 Identities = 66/228 (28%), Positives = 92/228 (40%), Gaps = 20/228 (8%)

Query: 701 DKGCDGPNADQCLNCVH--FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSS 758
           D  C   + + C  C    F LG       CV  C  G++GD     C  CH+ CETC+ 
Sbjct: 79  DSNCSSCDQNGCYWCEEGFFLLGG-----SCVRKCGPGFYGDQEMGECESCHRACETCTG 133

Query: 759 RAATQCLSCRRGFYHHQEMNTCVTLC-PAGFYADESQKNCLKCHPSCKKCVDEPEKCTVC 817
               +C SC+ G    + M    T     G + ++  +    CH SCK C      CT C
Sbjct: 134 PGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSC 193

Query: 818 KEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKN----FHFH 873
            +G  L   +C+  C  GT+       C  C   C  C   G + C  C          H
Sbjct: 194 PKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC--SGADLCKKCQMQPGHPLFLH 251

Query: 874 DWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTG 921
           + +C   C EG Y E+       +C RC   C +C G++ NC  C+ G
Sbjct: 252 EGRCYSKCPEGSYAED------GICERCSSPCRTCEGNATNCHSCEGG 293



 Score =  110 bits (275), Expect = 6e-24
 Identities = 78/245 (31%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 728 KCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAG 787
           +C S CP G + +     C RC   C TC   A T C SC  G   H     C   CP  
Sbjct: 254 RCYSKCPEGSYAEDGI--CERCSSPCRTCEGNA-TNCHSCEGGHVLHH--GVCQENCPER 308

Query: 788 FYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGE 847
             A E    C  C   C+ C+ E + C  C   F L    C   C  G Y DS    C  
Sbjct: 309 HVAVEGV--CKHCPEMCQDCIHE-KTCKECMPEFFLHDDMCHQSCPRGFYADSH--HCVP 363

Query: 848 CHHTCGTCVGPGREECIHCAK-NFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCL 906
           CH  C  C GP  ++C  C + ++  +D  C+  C  G Y E+      K CR C ++CL
Sbjct: 364 CHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKQT----KECRDCHKSCL 419

Query: 907 SCAGSSRNCSRCKTGFTQLGT-SCITNHTCSNADETFCEMVKSNRLCERKLF-----IQF 960
           +C+ SS  C+ C+ G       SC+ N  CS   E + E     + C  K F      + 
Sbjct: 420 TCS-SSGTCTTCQKGLIMNPRGSCMANEKCS-PSEYWDEDAPGCKPCHVKCFHCMGPAED 477

Query: 961 CCRTC 965
            C+TC
Sbjct: 478 QCQTC 482



 Score =  103 bits (258), Expect = 6e-22
 Identities = 61/204 (29%), Positives = 88/204 (43%), Gaps = 28/204 (13%)

Query: 765 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 824
           L C   F HH     C   CP   Y++  +  C  C  +C  C  +   C  C+EGF L 
Sbjct: 50  LKCGNRFDHH-----CYKTCPEKTYSEAVE--CKACDSNCSSC--DQNGCYWCEEGFFLL 100

Query: 825 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPAC--- 881
            GSC+  C PG Y D E+  C  CH  C TC GPG +EC  C +        CV A    
Sbjct: 101 GGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQ 160

Query: 882 GEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCIT---------- 931
            EG +  ++     +  + C  +C +C GS+  C+ C  G   L  +C++          
Sbjct: 161 EEGKFWNDI----LRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSV 216

Query: 932 -NHTCSNADETFCEMVKSNRLCER 954
            + +C N  E  C +     LC++
Sbjct: 217 RSGSCENCTEA-CAICSGADLCKK 239


>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
           sapiens]
          Length = 853

 Score =  141 bits (355), Expect = 3e-33
 Identities = 85/275 (30%), Positives = 119/275 (43%), Gaps = 25/275 (9%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH +C +  C GP AD C  C+  S   V     C+  CP G + +   + CR CHK C 
Sbjct: 364 CHKDCLE--CSGPKADDCELCLESSW--VLYDGLCLEECPAGTYYEKETKECRDCHKSCL 419

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVT--LCPAGFYADESQKNCLKCHPSCKKCVDEPE 812
           TCSS     C +C++G   +    +C+    C    Y DE    C  CH  C  C+   E
Sbjct: 420 TCSSSGT--CTTCQKGLIMNPR-GSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAE 476

Query: 813 -KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 871
            +C  C     L   +C+ DC  G Y D +  RC  CH +C TC G    +C  C   + 
Sbjct: 477 DQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 536

Query: 872 FHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRCKTGFTQLGTSCI 930
               +C+  C EG+Y +   G     C RC+ +C  C G    +C  C   F  L +   
Sbjct: 537 QLGKECLLQCREGYYADNSTGR----CERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGE 592

Query: 931 TNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTC 965
            + +C   D  + E  +S + CER      C  TC
Sbjct: 593 CHRSC--PDHYYVE--QSTQTCER------CHPTC 617



 Score =  133 bits (334), Expect = 9e-31
 Identities = 67/226 (29%), Positives = 100/226 (44%), Gaps = 23/226 (10%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH  C  + C+G ++ QC +C     G  +  ++C+  C  GY+ D +  RC RC++ C+
Sbjct: 513 CHSSC--RTCEGRHSRQCHSC---RPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE-K 813
            C     T CLSC R F+  +    C   CP  +Y ++S + C +CHP+C +C  +    
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627

Query: 814 CTVCKEGFSLARGSCIPDCEPGTY--FDSELIRCGECHHTCGTCVGPGREECIHCAKN-- 869
           C  C   + L  G C  DC  G Y   + E   C +CH +C  C GPG + C  C  N  
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLV 687

Query: 870 FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNC 915
            H  D  C+  C     P               + C  C  ++  C
Sbjct: 688 LHMDDSHCLHCCNTSDPPSA-------------QECCDCQDTTDEC 720



 Score =  116 bits (291), Expect = 9e-26
 Identities = 66/228 (28%), Positives = 92/228 (40%), Gaps = 20/228 (8%)

Query: 701 DKGCDGPNADQCLNCVH--FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSS 758
           D  C   + + C  C    F LG       CV  C  G++GD     C  CH+ CETC+ 
Sbjct: 79  DSNCGSCDQNGCYWCEEGFFLLGG-----SCVRKCGPGFYGDQEMGECESCHRACETCTG 133

Query: 759 RAATQCLSCRRGFYHHQEMNTCVTLC-PAGFYADESQKNCLKCHPSCKKCVDEPEKCTVC 817
               +C SC+ G    + M    T     G + ++  +    CH SCK C      CT C
Sbjct: 134 PGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSC 193

Query: 818 KEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKN----FHFH 873
            +G  L   +C+  C  GT+       C  C   C  C   G + C  C          H
Sbjct: 194 PKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC--SGADLCKKCQMQPGHPLFLH 251

Query: 874 DWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTG 921
           + +C   C EG Y E+       +C RC   C +C G++ NC  C+ G
Sbjct: 252 EGRCYSKCPEGSYAED------GICERCSSPCRTCEGNATNCHSCEGG 293



 Score =  108 bits (269), Expect = 3e-23
 Identities = 77/245 (31%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 728 KCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAG 787
           +C S CP G + +     C RC   C TC   A T C SC  G   H     C   CP  
Sbjct: 254 RCYSKCPEGSYAEDGI--CERCSSPCRTCEGNA-TNCHSCEGGHVLHH--GVCQENCPER 308

Query: 788 FYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGE 847
             A +    C  C   C+ C+ E + C  C   F L    C   C  G Y DS    C  
Sbjct: 309 HVAVKGV--CKHCPEMCQDCIHE-KTCKECTPEFFLHDDMCHQSCPRGFYADSR--HCVP 363

Query: 848 CHHTCGTCVGPGREECIHCAK-NFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCL 906
           CH  C  C GP  ++C  C + ++  +D  C+  C  G Y E+      K CR C ++CL
Sbjct: 364 CHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEK----ETKECRDCHKSCL 419

Query: 907 SCAGSSRNCSRCKTGFTQLGT-SCITNHTCSNADETFCEMVKSNRLCERKLF-----IQF 960
           +C+ SS  C+ C+ G       SC+ N  CS   E + E     + C  K F      + 
Sbjct: 420 TCS-SSGTCTTCQKGLIMNPRGSCMANEKCS-PSEYWDEDAPGCKPCHVKCFHCMGPAED 477

Query: 961 CCRTC 965
            C+TC
Sbjct: 478 QCQTC 482



 Score =  103 bits (256), Expect = 1e-21
 Identities = 61/204 (29%), Positives = 88/204 (43%), Gaps = 28/204 (13%)

Query: 765 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 824
           L C   F HH     C   CP   Y++  +  C  C  +C  C  +   C  C+EGF L 
Sbjct: 50  LKCGNRFDHH-----CYKTCPEKTYSEAVE--CKACDSNCGSC--DQNGCYWCEEGFFLL 100

Query: 825 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPAC--- 881
            GSC+  C PG Y D E+  C  CH  C TC GPG +EC  C +        CV A    
Sbjct: 101 GGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQ 160

Query: 882 GEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCIT---------- 931
            EG +  ++     +  + C  +C +C GS+  C+ C  G   L  +C++          
Sbjct: 161 EEGKFWNDI----LRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSV 216

Query: 932 -NHTCSNADETFCEMVKSNRLCER 954
            + +C N  E  C +     LC++
Sbjct: 217 RSGSCENCTEA-CAICSGADLCKK 239



 Score =  100 bits (250), Expect = 5e-21
 Identities = 65/227 (28%), Positives = 97/227 (42%), Gaps = 23/227 (10%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH  C  K C+G +A  C +C     G+   ++ CVS CP G +    +  C  C + C 
Sbjct: 176 CHSSC--KTCNG-SATLCTSCPK---GAYLLAQACVSSCPQGTWPSVRSGSCENCTEACA 229

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNT--CVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE 812
            CS   A  C  C+    H   ++   C + CP G YA++    C +C   C+ C     
Sbjct: 230 ICSG--ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGI--CERCSSPCRTCEGNAT 285

Query: 813 KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHF 872
            C  C+ G  L  G C  +C P  +   + + C  C   C  C+    + C  C   F  
Sbjct: 286 NCHSCEGGHVLHHGVCQENC-PERHVAVKGV-CKHCPEMCQDCIH--EKTCKECTPEFFL 341

Query: 873 HDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRC 918
           HD  C  +C  GFY +       + C  C ++CL C+G  + +C  C
Sbjct: 342 HDDMCHQSCPRGFYADS------RHCVPCHKDCLECSGPKADDCELC 382


>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
           sapiens]
          Length = 853

 Score =  141 bits (355), Expect = 3e-33
 Identities = 85/275 (30%), Positives = 119/275 (43%), Gaps = 25/275 (9%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH +C +  C GP AD C  C+  S   V     C+  CP G + +   + CR CHK C 
Sbjct: 364 CHKDCLE--CSGPKADDCELCLESSW--VLYDGLCLEECPAGTYYEKETKECRDCHKSCL 419

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVT--LCPAGFYADESQKNCLKCHPSCKKCVDEPE 812
           TCSS     C +C++G   +    +C+    C    Y DE    C  CH  C  C+   E
Sbjct: 420 TCSSSGT--CTTCQKGLIMNPR-GSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAE 476

Query: 813 -KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 871
            +C  C     L   +C+ DC  G Y D +  RC  CH +C TC G    +C  C   + 
Sbjct: 477 DQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 536

Query: 872 FHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRCKTGFTQLGTSCI 930
               +C+  C EG+Y +   G     C RC+ +C  C G    +C  C   F  L +   
Sbjct: 537 QLGKECLLQCREGYYADNSTGR----CERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGE 592

Query: 931 TNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTC 965
            + +C   D  + E  +S + CER      C  TC
Sbjct: 593 CHRSC--PDHYYVE--QSTQTCER------CHPTC 617



 Score =  133 bits (334), Expect = 9e-31
 Identities = 67/226 (29%), Positives = 100/226 (44%), Gaps = 23/226 (10%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH  C  + C+G ++ QC +C     G  +  ++C+  C  GY+ D +  RC RC++ C+
Sbjct: 513 CHSSC--RTCEGRHSRQCHSC---RPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE-K 813
            C     T CLSC R F+  +    C   CP  +Y ++S + C +CHP+C +C  +    
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627

Query: 814 CTVCKEGFSLARGSCIPDCEPGTY--FDSELIRCGECHHTCGTCVGPGREECIHCAKN-- 869
           C  C   + L  G C  DC  G Y   + E   C +CH +C  C GPG + C  C  N  
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLV 687

Query: 870 FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNC 915
            H  D  C+  C     P               + C  C  ++  C
Sbjct: 688 LHMDDSHCLHCCNTSDPPSA-------------QECCDCQDTTDEC 720



 Score =  116 bits (291), Expect = 9e-26
 Identities = 66/228 (28%), Positives = 92/228 (40%), Gaps = 20/228 (8%)

Query: 701 DKGCDGPNADQCLNCVH--FSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSS 758
           D  C   + + C  C    F LG       CV  C  G++GD     C  CH+ CETC+ 
Sbjct: 79  DSNCGSCDQNGCYWCEEGFFLLGG-----SCVRKCGPGFYGDQEMGECESCHRACETCTG 133

Query: 759 RAATQCLSCRRGFYHHQEMNTCVTLC-PAGFYADESQKNCLKCHPSCKKCVDEPEKCTVC 817
               +C SC+ G    + M    T     G + ++  +    CH SCK C      CT C
Sbjct: 134 PGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSC 193

Query: 818 KEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKN----FHFH 873
            +G  L   +C+  C  GT+       C  C   C  C   G + C  C          H
Sbjct: 194 PKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAIC--SGADLCKKCQMQPGHPLFLH 251

Query: 874 DWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTG 921
           + +C   C EG Y E+       +C RC   C +C G++ NC  C+ G
Sbjct: 252 EGRCYSKCPEGSYAED------GICERCSSPCRTCEGNATNCHSCEGG 293



 Score =  108 bits (269), Expect = 3e-23
 Identities = 77/245 (31%), Positives = 103/245 (42%), Gaps = 23/245 (9%)

Query: 728 KCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAG 787
           +C S CP G + +     C RC   C TC   A T C SC  G   H     C   CP  
Sbjct: 254 RCYSKCPEGSYAEDGI--CERCSSPCRTCEGNA-TNCHSCEGGHVLHH--GVCQENCPER 308

Query: 788 FYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGE 847
             A +    C  C   C+ C+ E + C  C   F L    C   C  G Y DS    C  
Sbjct: 309 HVAVKGV--CKHCPEMCQDCIHE-KTCKECTPEFFLHDDMCHQSCPRGFYADSR--HCVP 363

Query: 848 CHHTCGTCVGPGREECIHCAK-NFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCL 906
           CH  C  C GP  ++C  C + ++  +D  C+  C  G Y E+      K CR C ++CL
Sbjct: 364 CHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEK----ETKECRDCHKSCL 419

Query: 907 SCAGSSRNCSRCKTGFTQLGT-SCITNHTCSNADETFCEMVKSNRLCERKLF-----IQF 960
           +C+ SS  C+ C+ G       SC+ N  CS   E + E     + C  K F      + 
Sbjct: 420 TCS-SSGTCTTCQKGLIMNPRGSCMANEKCS-PSEYWDEDAPGCKPCHVKCFHCMGPAED 477

Query: 961 CCRTC 965
            C+TC
Sbjct: 478 QCQTC 482



 Score =  105 bits (262), Expect = 2e-22
 Identities = 62/204 (30%), Positives = 89/204 (43%), Gaps = 28/204 (13%)

Query: 765 LSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLA 824
           L C   F HH     C   CP   Y++E +  C  C  +C  C  +   C  C+EGF L 
Sbjct: 50  LKCGNRFDHH-----CYKTCPEKTYSEEVE--CKACDSNCGSC--DQNGCYWCEEGFFLL 100

Query: 825 RGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPAC--- 881
            GSC+  C PG Y D E+  C  CH  C TC GPG +EC  C +        CV A    
Sbjct: 101 GGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQ 160

Query: 882 GEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCIT---------- 931
            EG +  ++     +  + C  +C +C GS+  C+ C  G   L  +C++          
Sbjct: 161 EEGKFWNDI----LRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSV 216

Query: 932 -NHTCSNADETFCEMVKSNRLCER 954
            + +C N  E  C +     LC++
Sbjct: 217 RSGSCENCTEA-CAICSGADLCKK 239



 Score =  100 bits (250), Expect = 5e-21
 Identities = 65/227 (28%), Positives = 97/227 (42%), Gaps = 23/227 (10%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH  C  K C+G +A  C +C     G+   ++ CVS CP G +    +  C  C + C 
Sbjct: 176 CHSSC--KTCNG-SATLCTSCPK---GAYLLAQACVSSCPQGTWPSVRSGSCENCTEACA 229

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNT--CVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE 812
            CS   A  C  C+    H   ++   C + CP G YA++    C +C   C+ C     
Sbjct: 230 ICSG--ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGI--CERCSSPCRTCEGNAT 285

Query: 813 KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHF 872
            C  C+ G  L  G C  +C P  +   + + C  C   C  C+    + C  C   F  
Sbjct: 286 NCHSCEGGHVLHHGVCQENC-PERHVAVKGV-CKHCPEMCQDCIH--EKTCKECTPEFFL 341

Query: 873 HDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRC 918
           HD  C  +C  GFY +       + C  C ++CL C+G  + +C  C
Sbjct: 342 HDDMCHQSCPRGFYADS------RHCVPCHKDCLECSGPKADDCELC 382


>gi|108773804 Fraser syndrome 1 [Homo sapiens]
          Length = 4011

 Score =  129 bits (323), Expect = 2e-29
 Identities = 86/292 (29%), Positives = 114/292 (39%), Gaps = 37/292 (12%)

Query: 695  CHPECGDKGCDGPNADQ-CLNC--VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK 751
            CH  C     D  N    CL C   H+ L        CV  CP GY+ +  A  C++CH 
Sbjct: 809  CHHLCQHCAADLHNTGSICLRCQNAHYLL----LGDHCVPDCPSGYYAERGA--CKKCHS 862

Query: 752  GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEP 811
             C TC  R    C SC           TC T C  G Y D++   C  C+  C  C D  
Sbjct: 863  SCRTCQGRGPFSCSSCDTNLVL-SHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSC-DSQ 919

Query: 812  EKCTVCKEGFS-LARGSC-IPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKN 869
              CT C++    L  G C    C P  Y D     C EC  +C  C GP + +C+ C   
Sbjct: 920  ASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDG 979

Query: 870  FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSC 929
            +   D  CV  C   FY +        +C +CD  CL C G    C+RCK  F  L   C
Sbjct: 980  YVLQDGACVEQCLSSFYQDS------GLC-KCDSYCLQCQG-PHECTRCKGPFLLLEAQC 1031

Query: 930  I-----------TNHTCSNADETFCEMVKSNR--LCERKLFIQ--FCCRTCL 966
            +             H C+   +   +    +R  LC+   F++   C   C+
Sbjct: 1032 VQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVYNCV 1083



 Score =  127 bits (318), Expect = 7e-29
 Identities = 70/226 (30%), Positives = 95/226 (42%), Gaps = 20/226 (8%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           C P+C             L C       +    +CV  C  G++ D  +  C  CH+ C 
Sbjct: 468 CQPQCS-------TCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 814
            C       CL+CR    H      C + C  GFY    Q  C  C  SC  C     +C
Sbjct: 519 GCWGPTEKHCLACRDPL-HVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCGPSSPRC 575

Query: 815 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 874
             C E   L  G C+ +C PG Y+     RC  CH++C +C GP    C  C+       
Sbjct: 576 LTCTEKTVLHDGKCMSEC-PGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634

Query: 875 WKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRCK 919
             C+P CGEGFY +      H VC+ C  +CL+C G +  +C+ CK
Sbjct: 635 GHCLPRCGEGFYSD------HGVCKACHSSCLACMGPAPSHCTGCK 674



 Score =  125 bits (315), Expect = 1e-28
 Identities = 83/289 (28%), Positives = 121/289 (41%), Gaps = 48/289 (16%)

Query: 688 NILQTSVCHPECG-------------DKGCD--GPNADQCLNCVHFSLGSVKTSRKCVSV 732
           ++L+   C   CG             D+ CD  GP++ +CL C      +V    KC+S 
Sbjct: 536 HVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTE---KTVLHDGKCMSE 592

Query: 733 CPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADE 792
           CP GY+ D A  RC+ CH  C +CS    + C +C       Q    C+  C  GFY+D 
Sbjct: 593 CPGGYYAD-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ--GHCLPRCGEGFYSDH 649

Query: 793 SQKNCLKCHPSCKKCVDE-PEKCTVCK---EGFSLAR--------GSCIPDCEPGTYFDS 840
               C  CH SC  C+   P  CT CK   EG  + +        G C+  C    Y +S
Sbjct: 650 GV--CKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLES 707

Query: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLP-HKVCR 899
             I C  CH +C  C G     C  C  +    D +C+  C +G++ +E      H  CR
Sbjct: 708 TGI-CEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCR 766

Query: 900 RC----DENCLSC-------AGSSRNCSRCKTGFTQLGTSCITNHTCSN 937
           +C    + +C+SC        G+ R   R +     +G     +H C +
Sbjct: 767 QCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQH 815



 Score =  107 bits (266), Expect = 7e-23
 Identities = 76/284 (26%), Positives = 112/284 (39%), Gaps = 42/284 (14%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKT--------SRKCVSVCPLGYFGDTAARRC 746
           CH  C    C GP    C  C     G            S +C++ C   ++ ++    C
Sbjct: 655 CHSSC--LACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGI-C 711

Query: 747 RRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKK 806
             CH+ C  C+ ++   C  C  G  H      C++ CP G++  E   +C +CHP+C++
Sbjct: 712 EACHQSCFRCAGKSPHNCTDC--GPSHVLLDGQCLSQCPDGYFHQEG--SCTECHPTCRQ 767

Query: 807 CVDEPEK-CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE--- 862
           C    E  C  C    SL  G+C   C    + +  +  C +CHH C  C          
Sbjct: 768 CHGPLESDCISCYPHISLTNGNCRTSCREEQFLNL-VGYCADCHHLCQHCAADLHNTGSI 826

Query: 863 CIHCAKNFHF--HDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSR-NCSRCK 919
           C+ C +N H+      CVP C  G+Y E         C++C  +C +C G    +CS C 
Sbjct: 827 CLRC-QNAHYLLLGDHCVPDCPSGYYAE------RGACKKCHSSCRTCQGRGPFSCSSCD 879

Query: 920 TG--FTQLGTSCIT---------NHTCSNADETFCEMVKSNRLC 952
           T    +  GT   T         NH C   + T C    S   C
Sbjct: 880 TNLVLSHTGTCSTTCFPGHYLDDNHVCQPCN-THCGSCDSQASC 922



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 56/192 (29%), Positives = 72/192 (37%), Gaps = 15/192 (7%)

Query: 695  CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKC-VSVCPLGYFGDTAARRCRRCHKGC 753
            C+  CG   CD   +  C +C       V    +C    C   Y+ D +   C+ C   C
Sbjct: 909  CNTHCGS--CDSQAS--CTSCR--DPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSC 962

Query: 754  ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEK 813
              CS    T CL C  G+        CV  C + FY D       KC   C +C   P +
Sbjct: 963  SACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDSG---LCKCDSYCLQC-QGPHE 1016

Query: 814  CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFH 873
            CT CK  F L    C+ +C  G + D    +C  C   C  C    R+ C  C   F   
Sbjct: 1017 CTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHLCDHGFFLK 1074

Query: 874  DWKCVPACGEGF 885
               CV  C  GF
Sbjct: 1075 SGLCVYNCVPGF 1086



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 51/188 (27%), Positives = 66/188 (35%), Gaps = 61/188 (32%)

Query: 784 CPAGFYADESQKNC------LKCHPSCKKCVDEPEKCTVCKE----------------GF 821
           CP G  A E +  C      + CHP C  C   P+ C +C++                GF
Sbjct: 399 CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGF 458

Query: 822 SLA------------------------------RGSCIPDCEPGTYFDSELIRCGECHHT 851
             A                               G C+P C  G Y D     C  CH +
Sbjct: 459 YQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRH--SCAVCHES 516

Query: 852 CGTCVGPGREECIHCAKNFH-FHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG 910
           C  C GP  + C+ C    H   D  C  +CG+GFY  +        C  CD++C SC  
Sbjct: 517 CAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQ------GTCSACDQSCDSCGP 570

Query: 911 SSRNCSRC 918
           SS  C  C
Sbjct: 571 SSPRCLTC 578



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 42/148 (28%), Positives = 62/148 (41%), Gaps = 11/148 (7%)

Query: 704  CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 763
            C GP    CL C+    G V     CV  C   ++ D+    C+ C   C  C  +   +
Sbjct: 965  CSGPLKTDCLQCMD---GYVLQDGACVEQCLSSFYQDSGL--CK-CDSYCLQC--QGPHE 1016

Query: 764  CLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSL 823
            C  C+  F   +    CV  C  G++AD ++  C  C   C +C    ++C +C  GF L
Sbjct: 1017 CTRCKGPFLLLEAQ--CVQECGKGYFADHAKHKCTACPQGCLQC-SHRDRCHLCDHGFFL 1073

Query: 824  ARGSCIPDCEPGTYFDSELIRCGECHHT 851
              G C+ +C PG    +    C    HT
Sbjct: 1074 KSGLCVYNCVPGFSVHTSNETCSGKIHT 1101


>gi|116734855 cysteine-rich with EGF-like domains 1 isoform 3 [Homo
           sapiens]
          Length = 420

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 51/198 (25%), Positives = 72/198 (36%), Gaps = 39/198 (19%)

Query: 784 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGT------- 836
           CPAG +      +CL C    ++      +C    EG     GS   DC+ G        
Sbjct: 143 CPAGTFGP----SCLPCPGGTERPCGGYGQC----EGEGTRGGSGHCDCQAGYGGEACGQ 194

Query: 837 ----YFDSEL----IRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPA-------- 880
               YF++E     + C  C   C  C GP    C+ C K +  H  KCV          
Sbjct: 195 CGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGA 254

Query: 881 -CGEGFYPEEMPGLPHKVCRRCDENCLSCAGSS-RNCSRCKTGFTQLGTSCITNHTCSN- 937
            CG   +     G     CR C + CL C G+    C +C  G+ Q+G+ C+    C   
Sbjct: 255 NCGADQFCVNTEG--SYECRDCAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECETE 312

Query: 938 ---ADETFCEMVKSNRLC 952
               +   CE  +    C
Sbjct: 313 VCPGENKQCENTEGGYRC 330



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/116 (27%), Positives = 45/116 (38%), Gaps = 15/116 (12%)

Query: 733 CPLGYFG---DTAARRCRRCHKGCETCSSRAATQCLSCRRGF-YHH------QEMNTCVT 782
           C LGYF    + +   C  C   C  CS    + CL C++G+  HH       E  T   
Sbjct: 195 CGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGA 254

Query: 783 LCPAGFYA--DESQKNCLKCHPSCKKCVDE-PEKCTVCKEGFSLARGSC--IPDCE 833
            C A  +    E    C  C  +C  C+   P +C  C  G+      C  + +CE
Sbjct: 255 NCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECE 310



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 40/161 (24%), Positives = 56/161 (34%), Gaps = 28/161 (17%)

Query: 686 SANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFG------ 739
           +A+ L  S C   C    C GP    CL C     G      KCV +   G  G      
Sbjct: 205 NASHLVCSACFGPCAR--CSGPEESNCLQC---KKGWALHHLKCVDIDECGTEGANCGAD 259

Query: 740 -----DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ 794
                   +  CR C K C  C      +C  C  G+   Q  + C+ +       DE +
Sbjct: 260 QFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSPGY--QQVGSKCLDV-------DECE 310

Query: 795 KNCLKCHPSCKKCVD-EPEKCTVCKEGFSLARGSCIPDCEP 834
                C    K+C + E     +C EG+    G C+ +  P
Sbjct: 311 TEV--CPGENKQCENTEGGYRCICAEGYKQMEGICVKEQIP 349


>gi|72534728 cysteine-rich with EGF-like domains 1 isoform 1 [Homo
           sapiens]
          Length = 422

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 51/198 (25%), Positives = 72/198 (36%), Gaps = 39/198 (19%)

Query: 784 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGT------- 836
           CPAG +      +CL C    ++      +C    EG     GS   DC+ G        
Sbjct: 143 CPAGTFGP----SCLPCPGGTERPCGGYGQC----EGEGTRGGSGHCDCQAGYGGEACGQ 194

Query: 837 ----YFDSEL----IRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPA-------- 880
               YF++E     + C  C   C  C GP    C+ C K +  H  KCV          
Sbjct: 195 CGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGA 254

Query: 881 -CGEGFYPEEMPGLPHKVCRRCDENCLSCAGSS-RNCSRCKTGFTQLGTSCITNHTCSN- 937
            CG   +     G     CR C + CL C G+    C +C  G+ Q+G+ C+    C   
Sbjct: 255 NCGADQFCVNTEG--SYECRDCAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECETE 312

Query: 938 ---ADETFCEMVKSNRLC 952
               +   CE  +    C
Sbjct: 313 VCPGENKQCENTEGGYRC 330



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 45/174 (25%), Positives = 64/174 (36%), Gaps = 34/174 (19%)

Query: 733 CPLGYFG---DTAARRCRRCHKGCETCSSRAATQCLSCRRGF-YHH------QEMNTCVT 782
           C LGYF    + +   C  C   C  CS    + CL C++G+  HH       E  T   
Sbjct: 195 CGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGA 254

Query: 783 LCPAGFYA--DESQKNCLKCHPSCKKCVDE-PEKCTVCKEGFSLARGSC--IPDCE---- 833
            C A  +    E    C  C  +C  C+   P +C  C  G+      C  + +CE    
Sbjct: 255 NCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECETEVC 314

Query: 834 PGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYP 887
           PG           +C +T       G   CI CA+ +   +  CV     G +P
Sbjct: 315 PG--------ENKQCENT------EGGYRCI-CAEGYKQMEGICVKEQIPGAFP 353



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 41/164 (25%), Positives = 58/164 (35%), Gaps = 28/164 (17%)

Query: 686 SANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFG------ 739
           +A+ L  S C   C    C GP    CL C     G      KCV +   G  G      
Sbjct: 205 NASHLVCSACFGPCAR--CSGPEESNCLQC---KKGWALHHLKCVDIDECGTEGANCGAD 259

Query: 740 -----DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ 794
                   +  CR C K C  C      +C  C  G+   Q  + C+ +       DE +
Sbjct: 260 QFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSPGY--QQVGSKCLDV-------DECE 310

Query: 795 KNCLKCHPSCKKCVD-EPEKCTVCKEGFSLARGSCIPDCEPGTY 837
                C    K+C + E     +C EG+    G C+ +  PG +
Sbjct: 311 TEV--CPGENKQCENTEGGYRCICAEGYKQMEGICVKEQIPGAF 352


>gi|22095397 cysteine-rich with EGF-like domains 1 isoform 2 [Homo
           sapiens]
          Length = 420

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 51/198 (25%), Positives = 72/198 (36%), Gaps = 39/198 (19%)

Query: 784 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGT------- 836
           CPAG +      +CL C    ++      +C    EG     GS   DC+ G        
Sbjct: 143 CPAGTFGP----SCLPCPGGTERPCGGYGQC----EGEGTRGGSGHCDCQAGYGGEACGQ 194

Query: 837 ----YFDSEL----IRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPA-------- 880
               YF++E     + C  C   C  C GP    C+ C K +  H  KCV          
Sbjct: 195 CGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGA 254

Query: 881 -CGEGFYPEEMPGLPHKVCRRCDENCLSCAGSS-RNCSRCKTGFTQLGTSCITNHTCSN- 937
            CG   +     G     CR C + CL C G+    C +C  G+ Q+G+ C+    C   
Sbjct: 255 NCGADQFCVNTEG--SYECRDCAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECETE 312

Query: 938 ---ADETFCEMVKSNRLC 952
               +   CE  +    C
Sbjct: 313 VCPGENKQCENTEGGYRC 330



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/116 (27%), Positives = 45/116 (38%), Gaps = 15/116 (12%)

Query: 733 CPLGYFG---DTAARRCRRCHKGCETCSSRAATQCLSCRRGF-YHH------QEMNTCVT 782
           C LGYF    + +   C  C   C  CS    + CL C++G+  HH       E  T   
Sbjct: 195 CGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGA 254

Query: 783 LCPAGFYA--DESQKNCLKCHPSCKKCVDE-PEKCTVCKEGFSLARGSC--IPDCE 833
            C A  +    E    C  C  +C  C+   P +C  C  G+      C  + +CE
Sbjct: 255 NCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECE 310



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 40/161 (24%), Positives = 56/161 (34%), Gaps = 28/161 (17%)

Query: 686 SANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFG------ 739
           +A+ L  S C   C    C GP    CL C     G      KCV +   G  G      
Sbjct: 205 NASHLVCSACFGPCAR--CSGPEESNCLQC---KKGWALHHLKCVDIDECGTEGANCGAD 259

Query: 740 -----DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ 794
                   +  CR C K C  C      +C  C  G+   Q  + C+ +       DE +
Sbjct: 260 QFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSPGY--QQVGSKCLDV-------DECE 310

Query: 795 KNCLKCHPSCKKCVD-EPEKCTVCKEGFSLARGSCIPDCEP 834
                C    K+C + E     +C EG+    G C+ +  P
Sbjct: 311 TEV--CPGENKQCENTEGGYRCICAEGYKQMEGICVKEQIP 349


>gi|18490982 R-spondin 3 [Homo sapiens]
          Length = 272

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 40/133 (30%), Positives = 54/133 (40%), Gaps = 22/133 (16%)

Query: 737 YFGDTAARRCRR-----------CHKGCETCSSRAATQCLSCRRGFYHHQE------MNT 779
           Y G   A R RR           C  GC TCS      CLSC+   +   E      +  
Sbjct: 18  YIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNG--CLSCKPRLFFALERIGMKQIGV 75

Query: 780 CVTLCPAGFYADESQ--KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTY 837
           C++ CP+G+Y         C KC   C  C ++   CT CK GF L  G C+ +C  G  
Sbjct: 76  CLSSCPSGYYGTRYPDINKCTKCKADCDTCFNK-NFCTKCKSGFYLHLGKCLDNCPEGLE 134

Query: 838 FDSELIRCGECHH 850
            ++  + C    H
Sbjct: 135 ANNHTMECVSIVH 147



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 17/115 (14%)

Query: 696 HPECGDKGCDGPNA-----DQCLNC---VHFSLGSV--KTSRKCVSVCPLGYFGD--TAA 743
           HP    +GC G  A     + CL+C   + F+L  +  K    C+S CP GY+G      
Sbjct: 34  HPNVS-QGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI 92

Query: 744 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCL 798
            +C +C   C+TC ++    C  C+ GFY H  +  C+  CP G  A+     C+
Sbjct: 93  NKCTKCKADCDTCFNK--NFCTKCKSGFYLH--LGKCLDNCPEGLEANNHTMECV 143



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 13/95 (13%)

Query: 800 CHPSCKKCVDEPEKCTVCKEG--FSLAR------GSCIPDCEPGTYFDS--ELIRCGECH 849
           C   C  C D    C  CK    F+L R      G C+  C  G Y     ++ +C +C 
Sbjct: 41  CQGGCATCSDY-NGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCK 99

Query: 850 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 884
             C TC    +  C  C   F+ H  KC+  C EG
Sbjct: 100 ADCDTCFN--KNFCTKCKSGFYLHLGKCLDNCPEG 132



 Score = 38.9 bits (89), Expect = 0.024
 Identities = 28/119 (23%), Positives = 44/119 (36%), Gaps = 22/119 (18%)

Query: 848 CHHTCGTCVGPGREECIHCAKNFHFHDWK--------CVPACGEGFYPEEMPGLPHKVCR 899
           C   C TC       C+ C     F   +        C+ +C  G+Y    P +    C 
Sbjct: 41  CQGGCATC--SDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDI--NKCT 96

Query: 900 RCDENCLSCAGSSRNCSRCKTGFTQLGTSCI---------TNHTCSNADETFCEMVKSN 949
           +C  +C +C   +  C++CK+GF      C+          NHT        CE+ + N
Sbjct: 97  KCKADCDTCFNKNF-CTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWN 154


>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
          Length = 1342

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 44/158 (27%), Positives = 63/158 (39%), Gaps = 26/158 (16%)

Query: 672 PEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVS 731
           P +E      + P    + +  VC P C   GC GP   QCL+C ++S G V     CV+
Sbjct: 477 PTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGV-----CVT 531

Query: 732 VCPL--GYFGDTA-ARRCRRCHKGCE------TCSSRAATQCLSCRRGFYHHQEMNTCVT 782
            C    G   + A    C  CH  C+      TC+   +  C  C     H ++   CV+
Sbjct: 532 HCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCA----HFRDGPHCVS 587

Query: 783 LCPAG--------FYADESQKNCLKCHPSCKKCVDEPE 812
            CP G        +   + Q  C  CH +C +    PE
Sbjct: 588 SCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPE 625



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 48/168 (28%), Positives = 63/168 (37%), Gaps = 37/168 (22%)

Query: 772 YHHQEMNTCVTLCPAGFYAD----ESQKNCLK----CHPSCKK--CVDE-PEKCTVCKEG 820
           YHH    T V   P     D      +++C+     C P C    C    P +C  C+  
Sbjct: 464 YHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCR-- 521

Query: 821 FSLARGS-CIPDC-----EPGTYFDSELIRCGECHHTC------GTCVGPGREECIHCAK 868
            + +RG  C+  C     EP  +  +    C  CH  C       TC G G + C  CA 
Sbjct: 522 -NYSRGGVCVTHCNFLNGEPREF--AHEAECFSCHPECQPMEGTATCNGSGSDTCAQCA- 577

Query: 869 NFHFHDW-KCVPACGEGFYPEEMPGLPH----KVCRRCDENCL-SCAG 910
             HF D   CV +C  G    + P   +      CR C ENC   C G
Sbjct: 578 --HFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKG 623



 Score = 38.5 bits (88), Expect = 0.031
 Identities = 40/144 (27%), Positives = 49/144 (34%), Gaps = 43/144 (29%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC--PLGYFGDTAARRCRRCHKG 752
           CH EC   GC GP    C  C HF+      S  CV  C  PL Y            +K 
Sbjct: 227 CHDECAG-GCSGPQDTDCFACRHFN-----DSGACVPRCPQPLVY------------NKL 268

Query: 753 CETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPE 812
                    T+          +Q    CV  CP  F  D  Q +C++  P        P+
Sbjct: 269 TFQLEPNPHTK----------YQYGGVCVASCPHNFVVD--QTSCVRACP--------PD 308

Query: 813 KCTVCKEGFSLAR---GSCIPDCE 833
           K  V K G  +     G C   CE
Sbjct: 309 KMEVDKNGLKMCEPCGGLCPKACE 332



 Score = 37.4 bits (85), Expect = 0.069
 Identities = 26/78 (33%), Positives = 32/78 (41%), Gaps = 16/78 (20%)

Query: 845 CGECHHTC-GTCVGPGREECIHCAKNFHFHDWKCVPAC-GEGFYPEEMPGLPHKVCRRCD 902
           C  CH  C G C GPG E+C    K        C P C G  F P      P++ C   D
Sbjct: 183 CPPCHEVCKGRCWGPGSEDCQTLTKTI------CAPQCNGHCFGPN-----PNQCCH--D 229

Query: 903 ENCLSCAG-SSRNCSRCK 919
           E    C+G    +C  C+
Sbjct: 230 ECAGGCSGPQDTDCFACR 247


>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
           4 isoform JM-a/CVT-2 precursor [Homo sapiens]
          Length = 1292

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 42/138 (30%), Positives = 54/138 (39%), Gaps = 31/138 (22%)

Query: 694 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD-----------TA 742
           VC+  C   GC GP  DQCL+C  FS G     R C+  C L Y G+             
Sbjct: 502 VCNHLCSSDGCWGPGPDQCLSCRRFSRG-----RICIESCNL-YDGEFREFENGSICVEC 555

Query: 743 ARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF---------YADES 793
             +C +   G  TC       C  C     H ++   CV  CP G          YAD  
Sbjct: 556 DPQCEKMEDGLLTCHGPGPDNCTKCS----HFKDGPNCVEKCPDGLQGANSFIFKYAD-P 610

Query: 794 QKNCLKCHPSCKKCVDEP 811
            + C  CHP+C +  + P
Sbjct: 611 DRECHPCHPNCTQGCNGP 628



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 38/125 (30%), Positives = 48/125 (38%), Gaps = 28/125 (22%)

Query: 811 PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIR------CGECHHTCG-------TCVG 857
           P++C  C+  FS  R  CI  C     +D E         C EC   C        TC G
Sbjct: 517 PDQCLSCRR-FSRGR-ICIESCN---LYDGEFREFENGSICVECDPQCEKMEDGLLTCHG 571

Query: 858 PGREECIHCAKNFHFHDW-KCVPACGEGFYPEE----MPGLPHKVCRRCDENCL-SCAG- 910
           PG + C  C+   HF D   CV  C +G             P + C  C  NC   C G 
Sbjct: 572 PGPDNCTKCS---HFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGP 628

Query: 911 SSRNC 915
           +S +C
Sbjct: 629 TSHDC 633



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 30/117 (25%), Positives = 43/117 (36%), Gaps = 13/117 (11%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH EC   GC GP    C  C++F+      S  CV+ CP  +  +    +         
Sbjct: 230 CHRECAG-GCSGPKDTDCFACMNFN-----DSGACVTQCPQTFVYNPTTFQLEHNFNAKY 283

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ--KNCLKCHPSCKKCVD 809
           T  +    +   C   F    + ++CV  CP+     E    K C  C   C K  D
Sbjct: 284 TYGAFCVKK---CPHNFV--VDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACD 335



 Score = 37.7 bits (86), Expect = 0.052
 Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 17/83 (20%)

Query: 848 CHHTCGT--CVGPGREECIHCAKNFHFHDWKCVPACG--EGFYPEEMPGLPHKVCRRCDE 903
           C+H C +  C GPG ++C+ C +        C+ +C   +G + E   G    +C  CD 
Sbjct: 503 CNHLCSSDGCWGPGPDQCLSCRR--FSRGRICIESCNLYDGEFREFENG---SICVECDP 557

Query: 904 NC-------LSCAG-SSRNCSRC 918
            C       L+C G    NC++C
Sbjct: 558 QCEKMEDGLLTCHGPGPDNCTKC 580



 Score = 33.9 bits (76), Expect = 0.76
 Identities = 38/163 (23%), Positives = 51/163 (31%), Gaps = 21/163 (12%)

Query: 746 CRRCHKGCE-TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSC 804
           C RCHK C   C       C +  R          C   C    Y      +C  CH  C
Sbjct: 186 CGRCHKSCTGRCWGPTENHCQTLTR--------TVCAEQCDGRCYG-PYVSDC--CHREC 234

Query: 805 KKCVDEPE--KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE 862
                 P+   C  C   F+   G+C+  C     ++       +  H        G   
Sbjct: 235 AGGCSGPKDTDCFACM-NFN-DSGACVTQCPQTFVYNPTTF---QLEHNFNAKYTYGAFC 289

Query: 863 CIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENC 905
              C  NF      CV AC       E  G+  K+C+ C + C
Sbjct: 290 VKKCPHNFVVDSSSCVRACPSSKMEVEENGI--KMCKPCTDIC 330


>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
           isoform JM-a/CVT-1 precursor [Homo sapiens]
          Length = 1308

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 42/138 (30%), Positives = 54/138 (39%), Gaps = 31/138 (22%)

Query: 694 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD-----------TA 742
           VC+  C   GC GP  DQCL+C  FS G     R C+  C L Y G+             
Sbjct: 502 VCNHLCSSDGCWGPGPDQCLSCRRFSRG-----RICIESCNL-YDGEFREFENGSICVEC 555

Query: 743 ARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF---------YADES 793
             +C +   G  TC       C  C     H ++   CV  CP G          YAD  
Sbjct: 556 DPQCEKMEDGLLTCHGPGPDNCTKCS----HFKDGPNCVEKCPDGLQGANSFIFKYAD-P 610

Query: 794 QKNCLKCHPSCKKCVDEP 811
            + C  CHP+C +  + P
Sbjct: 611 DRECHPCHPNCTQGCNGP 628



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 38/125 (30%), Positives = 48/125 (38%), Gaps = 28/125 (22%)

Query: 811 PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIR------CGECHHTCG-------TCVG 857
           P++C  C+  FS  R  CI  C     +D E         C EC   C        TC G
Sbjct: 517 PDQCLSCRR-FSRGR-ICIESCN---LYDGEFREFENGSICVECDPQCEKMEDGLLTCHG 571

Query: 858 PGREECIHCAKNFHFHDW-KCVPACGEGFYPEE----MPGLPHKVCRRCDENCL-SCAG- 910
           PG + C  C+   HF D   CV  C +G             P + C  C  NC   C G 
Sbjct: 572 PGPDNCTKCS---HFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGP 628

Query: 911 SSRNC 915
           +S +C
Sbjct: 629 TSHDC 633



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 30/117 (25%), Positives = 43/117 (36%), Gaps = 13/117 (11%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           CH EC   GC GP    C  C++F+      S  CV+ CP  +  +    +         
Sbjct: 230 CHRECAG-GCSGPKDTDCFACMNFN-----DSGACVTQCPQTFVYNPTTFQLEHNFNAKY 283

Query: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ--KNCLKCHPSCKKCVD 809
           T  +    +   C   F    + ++CV  CP+     E    K C  C   C K  D
Sbjct: 284 TYGAFCVKK---CPHNFV--VDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACD 335



 Score = 37.7 bits (86), Expect = 0.052
 Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 17/83 (20%)

Query: 848 CHHTCGT--CVGPGREECIHCAKNFHFHDWKCVPACG--EGFYPEEMPGLPHKVCRRCDE 903
           C+H C +  C GPG ++C+ C +        C+ +C   +G + E   G    +C  CD 
Sbjct: 503 CNHLCSSDGCWGPGPDQCLSCRR--FSRGRICIESCNLYDGEFREFENG---SICVECDP 557

Query: 904 NC-------LSCAG-SSRNCSRC 918
            C       L+C G    NC++C
Sbjct: 558 QCEKMEDGLLTCHGPGPDNCTKC 580



 Score = 33.9 bits (76), Expect = 0.76
 Identities = 38/163 (23%), Positives = 51/163 (31%), Gaps = 21/163 (12%)

Query: 746 CRRCHKGCE-TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSC 804
           C RCHK C   C       C +  R          C   C    Y      +C  CH  C
Sbjct: 186 CGRCHKSCTGRCWGPTENHCQTLTR--------TVCAEQCDGRCYG-PYVSDC--CHREC 234

Query: 805 KKCVDEPE--KCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE 862
                 P+   C  C   F+   G+C+  C     ++       +  H        G   
Sbjct: 235 AGGCSGPKDTDCFACM-NFN-DSGACVTQCPQTFVYNPTTF---QLEHNFNAKYTYGAFC 289

Query: 863 CIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENC 905
              C  NF      CV AC       E  G+  K+C+ C + C
Sbjct: 290 VKKCPHNFVVDSSSCVRACPSSKMEVEENGI--KMCKPCTDIC 330


>gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo
           sapiens]
          Length = 870

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 49/162 (30%), Positives = 62/162 (38%), Gaps = 20/162 (12%)

Query: 729 CVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF 788
           C   CP G++G    RRC +C KG + C+  A  +CL+C  G+        C   C  GF
Sbjct: 269 CREPCPAGFYGLGCRRRCGQC-KGQQPCTV-AEGRCLTCEPGW----NGTKCDQPCATGF 322

Query: 789 YADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC--- 845
           Y +     C  C      C     KCT C  G+   R  C   C  GTY +     C   
Sbjct: 323 YGEGCSHRCPPCRDG-HACNHVTGKCTRCNAGWIGDR--CETKCSNGTYGEDCAFVCADC 379

Query: 846 --GECHHTCGTCV---GPGREEC-IHCAKNFHFHDWKCVPAC 881
             G C    G C+   G     C + C    H  D  C  AC
Sbjct: 380 GSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGAD--CAQAC 419



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 42/169 (24%), Positives = 62/169 (36%), Gaps = 25/169 (14%)

Query: 695 CHPECGDKGCDGPNA-----DQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRC 749
           C   CG   C G         +CL C     G+     KC   C  G++G+  + RC  C
Sbjct: 282 CRRRCGQ--CKGQQPCTVAEGRCLTCEPGWNGT-----KCDQPCATGFYGEGCSHRCPPC 334

Query: 750 HKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVD 809
             G   C +    +C  C  G+      + C T C  G Y ++    C  C      C  
Sbjct: 335 RDG-HAC-NHVTGKCTRCNAGWIG----DRCETKCSNGTYGEDCAFVCADC--GSGHCDF 386

Query: 810 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHH-TCGTCVG 857
           +  +C +C  G  +    C   C PG +  ++  +   CH  TC    G
Sbjct: 387 QSGRC-LCSPG--VHGPHCNVTCPPGLH-GADCAQACSCHEDTCDPVTG 431


>gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo
           sapiens]
          Length = 865

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 49/162 (30%), Positives = 62/162 (38%), Gaps = 20/162 (12%)

Query: 729 CVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF 788
           C   CP G++G    RRC +C KG + C+  A  +CL+C  G+        C   C  GF
Sbjct: 269 CREPCPAGFYGLGCRRRCGQC-KGQQPCTV-AEGRCLTCEPGW----NGTKCDQPCATGF 322

Query: 789 YADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC--- 845
           Y +     C  C      C     KCT C  G+   R  C   C  GTY +     C   
Sbjct: 323 YGEGCSHRCPPCRDG-HACNHVTGKCTRCNAGWIGDR--CETKCSNGTYGEDCAFVCADC 379

Query: 846 --GECHHTCGTCV---GPGREEC-IHCAKNFHFHDWKCVPAC 881
             G C    G C+   G     C + C    H  D  C  AC
Sbjct: 380 GSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGAD--CAQAC 419



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 42/169 (24%), Positives = 62/169 (36%), Gaps = 25/169 (14%)

Query: 695 CHPECGDKGCDGPNA-----DQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRC 749
           C   CG   C G         +CL C     G+     KC   C  G++G+  + RC  C
Sbjct: 282 CRRRCGQ--CKGQQPCTVAEGRCLTCEPGWNGT-----KCDQPCATGFYGEGCSHRCPPC 334

Query: 750 HKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVD 809
             G   C +    +C  C  G+      + C T C  G Y ++    C  C      C  
Sbjct: 335 RDG-HAC-NHVTGKCTRCNAGWIG----DRCETKCSNGTYGEDCAFVCADC--GSGHCDF 386

Query: 810 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHH-TCGTCVG 857
           +  +C +C  G  +    C   C PG +  ++  +   CH  TC    G
Sbjct: 387 QSGRC-LCSPG--VHGPHCNVTCPPGLH-GADCAQACSCHEDTCDPVTG 431


>gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Homo
           sapiens]
          Length = 353

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 56/233 (24%), Positives = 80/233 (34%), Gaps = 47/233 (20%)

Query: 723 VKTSRKCVSVCPLGYFGDTAARRCRRCHKG----------CETCSSRAATQCLSCRRGFY 772
           VKT + C   C  G +G      C  C  G          C    SR       C  G+ 
Sbjct: 121 VKTLKVC---CSPGTYGPD----CLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGY- 172

Query: 773 HHQEMNTCVTLCPAGFYA---DESQKNCLKCHPSCKKCVDEPEK-CTVCKEGFSLARGSC 828
                    T C  G+++   +E+   C  C  SCK C     + C  C+ G+ L  G+C
Sbjct: 173 ----QGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGAC 228

Query: 829 I---------PDCEPGTYFDSE--LIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKC 877
           +         P C    +  +      C EC  +C  C G G   C  C   +     +C
Sbjct: 229 VDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQC 288

Query: 878 VPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCI 930
                      +   L  K C R +ENC +  GS      C  GF +   +C+
Sbjct: 289 ADV--------DECSLAEKTCVRKNENCYNTPGS--YVCVCPDGFEETEDACV 331



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 49/200 (24%), Positives = 69/200 (34%), Gaps = 36/200 (18%)

Query: 777 MNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSC-------- 828
           + T    C  G Y  +    CL C    ++       C+   +G     GSC        
Sbjct: 121 VKTLKVCCSPGTYGPD----CLACQGGSQRPCSGNGHCS--GDGSRQGDGSCRCHMGYQG 174

Query: 829 --IPDCEPGTYFDSELIR----CGECHHTCGTCVGPGREECIHCAKNFHFHDWKCV---- 878
               DC  G YF S        C  C  +C TC G    +C  C   +   +  CV    
Sbjct: 175 PLCTDCMDG-YFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDE 233

Query: 879 -----PACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSR-NCSRCKTGFTQLGTSCITN 932
                P C    + +   G     C  CD +C+ C G    NC  C +G+ +    C   
Sbjct: 234 CAAEPPPCSAAQFCKNANG--SYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADV 291

Query: 933 HTCSNADETFCEMVKSNRLC 952
             CS A++T    V+ N  C
Sbjct: 292 DECSLAEKT---CVRKNENC 308



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 12/132 (9%)

Query: 832 CEPGTYFDSELIRCGECHHTC---GTCVGPG-REECIHCAKNFHFHDWKCVPACGEGFYP 887
           C PGTY    L   G     C   G C G G R+    C  +  +    C   C +G++ 
Sbjct: 128 CSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTD-CMDGYF- 185

Query: 888 EEMPGLPHKVCRRCDENCLSCAG-SSRNCSRCKTGFTQLGTSCITNHTCSN-----ADET 941
             +    H +C  CDE+C +C+G ++R+C  C+ G+     +C+    C+      +   
Sbjct: 186 SSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQ 245

Query: 942 FCEMVKSNRLCE 953
           FC+    +  CE
Sbjct: 246 FCKNANGSYTCE 257



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 34/152 (22%), Positives = 48/152 (31%), Gaps = 24/152 (15%)

Query: 693 SVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSV---------CPLGYFGDTA- 742
           + C   C  K C G     C  C    +G V     CV V         C    F   A 
Sbjct: 197 TACDESC--KTCSGLTNRDCGEC---EVGWVLDEGACVDVDECAAEPPPCSAAQFCKNAN 251

Query: 743 -ARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCH 801
            +  C  C   C  C+      C  C  G+         V  C        ++K C++ +
Sbjct: 252 GSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSL------AEKTCVRKN 305

Query: 802 PSCKKCVDEPEKCTVCKEGFSLARGSCIPDCE 833
            +C           VC +GF     +C+P  E
Sbjct: 306 ENCYNTPGS--YVCVCPDGFEETEDACVPPAE 335


>gi|29725609 epidermal growth factor receptor isoform a precursor
           [Homo sapiens]
          Length = 1210

 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)

Query: 694 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 749
           VCH  C  +GC GP    C++C + S G     R+CV  C L   G+         C +C
Sbjct: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558

Query: 750 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 793
           H  C       TC+ R    C+ C     H+ +   CV  CPAG           YAD  
Sbjct: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614

Query: 794 QKNCLKCHPSC 804
              C  CHP+C
Sbjct: 615 HV-CHLCHPNC 624



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 39/133 (29%), Positives = 51/133 (38%), Gaps = 30/133 (22%)

Query: 800 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 850
           CH  C        EP  C  C+   +++RG  C+  C     EP  + ++    C +CH 
Sbjct: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560

Query: 851 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPEEMPGL-----PHKVC 898
            C       TC G G + CI CA   H+ D   CV  C  G   E    +        VC
Sbjct: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617

Query: 899 RRCDENC-LSCAG 910
             C  NC   C G
Sbjct: 618 HLCHPNCTYGCTG 630



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 753
           CH +C   GC GP    CL C  F     +    C   C PL  +  T      +     
Sbjct: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281

Query: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 806
           E   S  AT    C R  Y   +  +CV  C A  Y   ++  + C KC   C+K
Sbjct: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           C P C +  C G   + C       L  +  +++C   C      D        CH  C 
Sbjct: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237

Query: 755 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 805
             C+    + CL CR+     ++  TC   C       P  +  D + +       +C K
Sbjct: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293

Query: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 863
           KC   P    V         GSC+  C   +Y   E     +    C  C GP R+ C
Sbjct: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337



 Score = 30.4 bits (67), Expect = 8.4
 Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)

Query: 796 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 846
           +C KC PSC    C     +  +K T  +C +  S   RG    DC              
Sbjct: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231

Query: 847 ECHHTCGT-CVGPGREECIHCAK 868
            CH+ C   C GP   +C+ C K
Sbjct: 232 -CHNQCAAGCTGPRESDCLVCRK 253


>gi|41327736 epidermal growth factor receptor isoform d precursor
           [Homo sapiens]
          Length = 705

 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)

Query: 694 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 749
           VCH  C  +GC GP    C++C + S G     R+CV  C L   G+         C +C
Sbjct: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558

Query: 750 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 793
           H  C       TC+ R    C+ C     H+ +   CV  CPAG           YAD  
Sbjct: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614

Query: 794 QKNCLKCHPSC 804
              C  CHP+C
Sbjct: 615 HV-CHLCHPNC 624



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 37/127 (29%), Positives = 49/127 (38%), Gaps = 29/127 (22%)

Query: 800 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 850
           CH  C        EP  C  C+   +++RG  C+  C     EP  + ++    C +CH 
Sbjct: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560

Query: 851 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPEEMPGL-----PHKVC 898
            C       TC G G + CI CA   H+ D   CV  C  G   E    +        VC
Sbjct: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617

Query: 899 RRCDENC 905
             C  NC
Sbjct: 618 HLCHPNC 624



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 753
           CH +C   GC GP    CL C  F     +    C   C PL  +  T      +     
Sbjct: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281

Query: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 806
           E   S  AT    C R  Y   +  +CV  C A  Y   ++  + C KC   C+K
Sbjct: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)

Query: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
           C P C +  C G   + C       L  +  +++C   C      D        CH  C 
Sbjct: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237

Query: 755 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 805
             C+    + CL CR+     ++  TC   C       P  +  D + +       +C K
Sbjct: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293

Query: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 863
           KC   P    V         GSC+  C   +Y   E     +    C  C GP R+ C
Sbjct: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337



 Score = 30.4 bits (67), Expect = 8.4
 Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)

Query: 796 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 846
           +C KC PSC    C     +  +K T  +C +  S   RG    DC              
Sbjct: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231

Query: 847 ECHHTCGT-CVGPGREECIHCAK 868
            CH+ C   C GP   +C+ C K
Sbjct: 232 -CHNQCAAGCTGPRESDCLVCRK 253


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,903,189
Number of Sequences: 37866
Number of extensions: 2532480
Number of successful extensions: 25723
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 229
Number of HSP's successfully gapped in prelim test: 468
Number of HSP's that attempted gapping in prelim test: 19844
Number of HSP's gapped (non-prelim): 4884
length of query: 969
length of database: 18,247,518
effective HSP length: 112
effective length of query: 857
effective length of database: 14,006,526
effective search space: 12003592782
effective search space used: 12003592782
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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