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Search of human proteins with 4505319
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505319 protein phosphatase 1, regulatory (inhibitor)
subunit 12B isoform a [Homo sapiens]
(982 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 1924 0.0
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 1890 0.0
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 869 0.0
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 869 0.0
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun... 758 0.0
gi|14195597 protein phosphatase 1, regulatory (inhibitor) subuni... 401 e-111
gi|14195599 protein phosphatase 1, regulatory (inhibitor) subuni... 366 e-101
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 332 1e-90
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni... 206 9e-53
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1... 198 2e-50
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 127 4e-29
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 110 5e-24
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 106 9e-23
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 106 9e-23
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 106 9e-23
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 106 9e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 106 1e-22
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 102 2e-21
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 101 3e-21
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 101 3e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 98 4e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 96 2e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 96 2e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 96 2e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 96 2e-19
gi|56090539 dysferlin-interacting protein 1 [Homo sapiens] 96 2e-19
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 96 2e-19
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 95 4e-19
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 95 4e-19
gi|18079216 CASK interacting protein 1 [Homo sapiens] 94 5e-19
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform a [Homo sapiens]
Length = 982
Score = 1924 bits (4985), Expect = 0.0
Identities = 982/982 (100%), Positives = 982/982 (100%)
Query: 1 MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA
Sbjct: 1 MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60
Query: 61 VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120
VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ
Sbjct: 61 VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120
Query: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
Query: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG
Sbjct: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
Query: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL
Sbjct: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
Query: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360
LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS
Sbjct: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360
Query: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420
SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS
Sbjct: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420
Query: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480
SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL
Sbjct: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480
Query: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540
LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI
Sbjct: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540
Query: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600
PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV
Sbjct: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600
Query: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660
LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT
Sbjct: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660
Query: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720
FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR
Sbjct: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720
Query: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN
Sbjct: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
Query: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840
EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG
Sbjct: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840
Query: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900
GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL
Sbjct: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900
Query: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELK 960
QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELK
Sbjct: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELK 960
Query: 961 SDNQRLKDENGALIRVISKLSK 982
SDNQRLKDENGALIRVISKLSK
Sbjct: 961 SDNQRLKDENGALIRVISKLSK 982
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform b [Homo sapiens]
Length = 998
Score = 1890 bits (4895), Expect = 0.0
Identities = 967/988 (97%), Positives = 975/988 (98%), Gaps = 6/988 (0%)
Query: 1 MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA
Sbjct: 1 MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60
Query: 61 VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120
VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ
Sbjct: 61 VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120
Query: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
Query: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG
Sbjct: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
Query: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL
Sbjct: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
Query: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360
LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS
Sbjct: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360
Query: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420
SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS
Sbjct: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420
Query: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480
SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL
Sbjct: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480
Query: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540
LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI
Sbjct: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540
Query: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600
PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV
Sbjct: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600
Query: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660
LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT
Sbjct: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660
Query: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720
FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR
Sbjct: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720
Query: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN
Sbjct: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
Query: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840
EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG
Sbjct: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840
Query: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900
GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL
Sbjct: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900
Query: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTE-- 958
QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK L +
Sbjct: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLK 960
Query: 959 ----LKSDNQRLKDENGALIRVISKLSK 982
LK N++L+ EN AL RV+++LS+
Sbjct: 961 QIQTLKQMNEQLQAENRALTRVVARLSE 988
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 869 bits (2245), Expect = 0.0
Identities = 518/1053 (49%), Positives = 678/1053 (64%), Gaps = 113/1053 (10%)
Query: 15 ARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEV 74
A+ +R EQL+RW GS T+ EP P+ +R +V+F+DGAVFLAACSSGDTDEV
Sbjct: 6 AKQKRNEQLKRWIGSETDLEP---------PVVKRQKTKVKFDDGAVFLAACSSGDTDEV 56
Query: 75 RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
KLL RGADIN NVDGLTALHQACID+N+DMVKFLVEN AN+NQ DNEGW PLHAAASC
Sbjct: 57 LKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASC 116
Query: 135 GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
GYL+IAE+ I GA VG VNSEG+ P D+AEE AM++LL +V +QG+D+E +RKEEE+
Sbjct: 117 GYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERI 176
Query: 195 MLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPL 254
ML+DARQWLNSG I DVR A+SG TALHVAAAKGY+EVL+LLIQAGY++N++DYDGWTPL
Sbjct: 177 MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPL 236
Query: 255 HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK-E 313
HAAAHWG +EAC IL + LCDM++ NK+GQT FDVADE ++ +LE LQKKQN+L SEK +
Sbjct: 237 HAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRD 296
Query: 314 TRNKLIES--DLNSKIQSGFFKNKEKMLYEE----------ETPKSQEMEEENKESSSSS 361
++ LIES ++++ FKNKE ++ E E K E EE K+ SS S
Sbjct: 297 KKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356
Query: 362 SEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSA---SSARR 418
SEE+E +D SE+ET+K KP A V ++N+ S + + P ++ A S ++
Sbjct: 357 SEEDEEDDSESEAETDK---TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKK 413
Query: 419 F---SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSS-IYRSSSS 474
F ++ + K EE KDESP++WRLGLRKTGS+ L+E+ S+E +++ ++ + RS+SS
Sbjct: 414 FPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASS 473
Query: 475 PRISALLDNKDKERENK----SYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQL 530
PR+S+ LDNK+KE+++K +Y++ PR+L STSDIEEKENR+S+ +L S SYTR+
Sbjct: 474 PRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSS-SLRTSSSYTRRK 532
Query: 531 WRDEAKGN-------------------------EIPQTIAPSTY-------------VST 552
W D+ K N +P T + T ST
Sbjct: 533 WEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTST 592
Query: 553 YLKRTPHKSQADTT--------AEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSIT 604
K T S A T AE + + S P V T P+ N +T L+ T
Sbjct: 593 TTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV-TIPVAPTVVNAAASTTTLTTT 651
Query: 605 --GT-DSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTF 661
GT S+ E RE+RRSYLTPVRDEE+ES RKARSRQARQ+RRSTQGVTLTDLQEAE+T
Sbjct: 652 TAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTI 711
Query: 662 SRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRL 721
RSR+ R +++ EK + + + ++ E + E +Q + R+ DE +R
Sbjct: 712 GRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYR- 770
Query: 722 RCPAQPDKPTTPASP-STSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
P TTP+S ST SLY SS L NR + +S + T E + +
Sbjct: 771 --PVSTSSSTTPSSSLSTMSSSLYASSQL---NRPNSLVGITSAYSRGITKENEREGEKR 825
Query: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETWHE 832
EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET +
Sbjct: 826 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885
Query: 833 RLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYESA 889
+SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 886 SISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQI 939
Query: 890 LTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEM 949
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++SEM
Sbjct: 940 LAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRISEM 997
Query: 950 EEEMKVLTELKSDNQRLKDENGALIRVISKLSK 982
EEE+K+L +LK+DNQRLKDENGALIRVISKLSK
Sbjct: 998 EEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
isoform a [Homo sapiens]
Length = 1030
Score = 869 bits (2245), Expect = 0.0
Identities = 518/1053 (49%), Positives = 678/1053 (64%), Gaps = 113/1053 (10%)
Query: 15 ARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEV 74
A+ +R EQL+RW GS T+ EP P+ +R +V+F+DGAVFLAACSSGDTDEV
Sbjct: 6 AKQKRNEQLKRWIGSETDLEP---------PVVKRQKTKVKFDDGAVFLAACSSGDTDEV 56
Query: 75 RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
KLL RGADIN NVDGLTALHQACID+N+DMVKFLVEN AN+NQ DNEGW PLHAAASC
Sbjct: 57 LKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASC 116
Query: 135 GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
GYL+IAE+ I GA VG VNSEG+ P D+AEE AM++LL +V +QG+D+E +RKEEE+
Sbjct: 117 GYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERI 176
Query: 195 MLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPL 254
ML+DARQWLNSG I DVR A+SG TALHVAAAKGY+EVL+LLIQAGY++N++DYDGWTPL
Sbjct: 177 MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPL 236
Query: 255 HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK-E 313
HAAAHWG +EAC IL + LCDM++ NK+GQT FDVADE ++ +LE LQKKQN+L SEK +
Sbjct: 237 HAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRD 296
Query: 314 TRNKLIES--DLNSKIQSGFFKNKEKMLYEE----------ETPKSQEMEEENKESSSSS 361
++ LIES ++++ FKNKE ++ E E K E EE K+ SS S
Sbjct: 297 KKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356
Query: 362 SEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSA---SSARR 418
SEE+E +D SE+ET+K KP A V ++N+ S + + P ++ A S ++
Sbjct: 357 SEEDEEDDSESEAETDK---TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKK 413
Query: 419 F---SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSS-IYRSSSS 474
F ++ + K EE KDESP++WRLGLRKTGS+ L+E+ S+E +++ ++ + RS+SS
Sbjct: 414 FPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASS 473
Query: 475 PRISALLDNKDKERENK----SYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQL 530
PR+S+ LDNK+KE+++K +Y++ PR+L STSDIEEKENR+S+ +L S SYTR+
Sbjct: 474 PRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSS-SLRTSSSYTRRK 532
Query: 531 WRDEAKGN-------------------------EIPQTIAPSTY-------------VST 552
W D+ K N +P T + T ST
Sbjct: 533 WEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTST 592
Query: 553 YLKRTPHKSQADTT--------AEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSIT 604
K T S A T AE + + S P V T P+ N +T L+ T
Sbjct: 593 TTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV-TIPVAPTVVNAAASTTTLTTT 651
Query: 605 --GT-DSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTF 661
GT S+ E RE+RRSYLTPVRDEE+ES RKARSRQARQ+RRSTQGVTLTDLQEAE+T
Sbjct: 652 TAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTI 711
Query: 662 SRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRL 721
RSR+ R +++ EK + + + ++ E + E +Q + R+ DE +R
Sbjct: 712 GRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYR- 770
Query: 722 RCPAQPDKPTTPASP-STSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
P TTP+S ST SLY SS L NR + +S + T E + +
Sbjct: 771 --PVSTSSSTTPSSSLSTMSSSLYASSQL---NRPNSLVGITSAYSRGITKENEREGEKR 825
Query: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETWHE 832
EE E S+ SIRERRRP+E+RR TG++FWT+D DE T+ KET +
Sbjct: 826 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885
Query: 833 RLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYESA 889
+SR E T+S S GDR + R + L +SR+E+D + D+KKLYE
Sbjct: 886 SISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQI 939
Query: 890 LTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEM 949
L EN+KLK +L + +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++SEM
Sbjct: 940 LAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRISEM 997
Query: 950 EEEMKVLTELKSDNQRLKDENGALIRVISKLSK 982
EEE+K+L +LK+DNQRLKDENGALIRVISKLSK
Sbjct: 998 EEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform b [Homo sapiens]
Length = 943
Score = 758 bits (1958), Expect = 0.0
Identities = 460/962 (47%), Positives = 609/962 (63%), Gaps = 104/962 (10%)
Query: 106 MVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAE 165
MVKFLVEN AN+NQ DNEGW PLHAAASCGYL+IAE+ I GA VG VNSEG+ P D+AE
Sbjct: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
Query: 166 EPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225
E AM++LL +V +QG+D+E +RKEEE+ ML+DARQWLNSG I DVR A+SG TALHVAA
Sbjct: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
AKGY+EVL+LLIQAGY++N++DYDGWTPLHAAAHWG +EAC IL + LCDM++ NK+GQT
Sbjct: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
Query: 286 PFDVADEGLVEHLELLQKKQNVLRSEK-ETRNKLIES--DLNSKIQSGFFKNKEKMLYEE 342
FDVADE ++ +LE LQKKQN+L SEK + ++ LIES ++++ FKNKE ++ E
Sbjct: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
Query: 343 ----------ETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN 392
E K E EE K+ SS SSEE+E +D SE+ET+K KP A V ++N
Sbjct: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDK---TKPLASVTNAN 297
Query: 393 SESKSSITEQIPAPAQNTFSA---SSARRF---SSGLFNKPEEPKDESPSSWRLGLRKTG 446
+ S + + P ++ A S ++F ++ + K EE KDESP++WRLGLRKTG
Sbjct: 298 TSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTG 357
Query: 447 SHNMLSEVANSREPIRDRGSS-IYRSSSSPRISALLDNKDKERENK----SYISSLAPRK 501
S+ L+E+ S+E +++ ++ + RS+SSPR+S+ LDNK+KE+++K +Y++ PR+
Sbjct: 358 SYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRR 417
Query: 502 LNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGN----------------------- 538
L STSDIEEKENR+S+ +L S SYTR+ W D+ K N
Sbjct: 418 LASTSDIEEKENRDSS-SLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLI 476
Query: 539 --EIPQTIAPSTY-------------VSTYLKRTPHKSQADTT--------AEKTADNVS 575
+P T + T ST K T S A T AE + +
Sbjct: 477 SSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK 536
Query: 576 SSTPLCVITNRPLPSTANGVTATPVLSIT--GT-DSSVEAREKRRSYLTPVRDEEAESLR 632
S P V T P+ N +T L+ T GT S+ E RE+RRSYLTPVRDEE+ES R
Sbjct: 537 DSVPTAV-TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQR 595
Query: 633 KARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHE 692
KARSRQARQ+RRSTQGVTLTDLQEAE+T RSR+ R +++ EK + + + ++ E
Sbjct: 596 KARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEE 655
Query: 693 PSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASP-STSRPSLYTSSHLLW 751
+ E +Q + R+ DE +R P TTP+S ST SLY SS L
Sbjct: 656 KKESETSREDEYKQKYSRTYDETYQRYR---PVSTSSSTTPSSSLSTMSSSLYASSQL-- 710
Query: 752 TNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGIN 811
NR + +S + T E + + EE E S+ SIRERRRP+E+RR TG++
Sbjct: 711 -NRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVS 769
Query: 812 FWTKDEDE--------TDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAR 863
FWT+D DE T+ KET + +SR E T+S S GDR + R
Sbjct: 770 FWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYE------TSSTSAGDRYDSLLGRSGS 823
Query: 864 EARL---ATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQ 920
+ L +SR+E+D + D+KKLYE L EN+KLK +L + +EL D+K +LEK A Q
Sbjct: 824 YSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEK-ATQ 882
Query: 921 KQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIRVISKL 980
+QE+ +DR S+LEMEKRERRALER++SEMEEE+K+L +LK+DNQRLKDENGALIRVISKL
Sbjct: 883 RQERFADR-SLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKL 941
Query: 981 SK 982
SK
Sbjct: 942 SK 943
Score = 59.3 bits (142), Expect = 2e-08
Identities = 43/173 (24%), Positives = 82/173 (47%), Gaps = 17/173 (9%)
Query: 33 QEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGL 92
Q R+G + R+ R+ D +L +SG ++VR + G
Sbjct: 69 QNEVNRQGVDIEA-ARKEEERIMLRDARQWL---NSGHINDVRHAKSGG----------- 113
Query: 93 TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
TALH A +++K L++ +VN +D +GWTPLHAAA G +++ + +
Sbjct: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173
Query: 153 VNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNS 205
VN G+ D+A+E + LE+++K+ L +++++ +++ N+
Sbjct: 174 VNKVGQTAFDVADEDILG--YLEELQKKQNLLHSEKRDKKSPLIESTANMDNN 224
>gi|14195597 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform c [Homo sapiens]
Length = 208
Score = 401 bits (1030), Expect = e-111
Identities = 208/208 (100%), Positives = 208/208 (100%)
Query: 775 MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 834
MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL
Sbjct: 1 MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 60
Query: 835 SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 894
SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ
Sbjct: 61 SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 120
Query: 895 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 954
KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK
Sbjct: 121 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 180
Query: 955 VLTELKSDNQRLKDENGALIRVISKLSK 982
VLTELKSDNQRLKDENGALIRVISKLSK
Sbjct: 181 VLTELKSDNQRLKDENGALIRVISKLSK 208
>gi|14195599 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform d [Homo sapiens]
Length = 224
Score = 366 bits (940), Expect = e-101
Identities = 193/214 (90%), Positives = 201/214 (93%), Gaps = 6/214 (2%)
Query: 775 MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 834
MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL
Sbjct: 1 MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 60
Query: 835 SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 894
SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ
Sbjct: 61 SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 120
Query: 895 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 954
KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK
Sbjct: 121 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 180
Query: 955 VLTE------LKSDNQRLKDENGALIRVISKLSK 982
L + LK N++L+ EN AL RV+++LS+
Sbjct: 181 NLHQLKQIQTLKQMNEQLQAENRALTRVVARLSE 214
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 332 bits (851), Expect = 1e-90
Identities = 246/732 (33%), Positives = 350/732 (47%), Gaps = 95/732 (12%)
Query: 9 GKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68
G A +AR RR EQLR+W R GA P RR VRFE A FLAAC+
Sbjct: 12 GAAAAAARERRREQLRQW---------GARAGAEPGPGERRART-VRFERAAEFLAACAG 61
Query: 69 GDTDEVRKLLARGAD------------------INTVNVDGLTALHQACIDENLDMVKFL 110
GD DE R L+ R AD +++ N DG++ALHQACIDENL++V+FL
Sbjct: 62 GDLDEAR-LMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFL 120
Query: 111 VENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMK 170
VE A VNQ DNEGWTPLH AASCGYL+IA Y ++HGA++ VNS+G++P DLAE AM+
Sbjct: 121 VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME 180
Query: 171 DLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
LL ++ ++G+D+E +++ EE+ +L D R WLN G + + R R+GA+ALHVAAAKGY
Sbjct: 181 GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI 240
Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
EV+RLL+QAGY+ ++D DGWTPLHAAAHWGV++AC +LAE MD GQ P D+A
Sbjct: 241 EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
Query: 291 DEGLVEHLELLQKKQNVLRSEKE---TRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKS 347
DE ++ LE L +KQ LR++KE +R + ++ +SK + ++ L E
Sbjct: 301 DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHR----RSSVCRLSSREKISL 356
Query: 348 QEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPA 407
Q++ +E + + ++ EDE E TE P PA
Sbjct: 357 QDLSKERRPGGAGGPPIQD-EDEGEEGPTE--------------------------PPPA 389
Query: 408 QNTFSASSARRFSSGLFNKPEEP--KDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRG 465
+ + SS P+ P +E+P S R GL KTGS L R G
Sbjct: 390 E----PRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGP-PERRTAEGAPG 444
Query: 466 SSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGS 525
+ + RS+SS + + R + I+ KL S + E + + S
Sbjct: 445 AGLQRSASSSWLEGTSTQAKELR--LARITPTPSPKLPEPSVLSEVTKPPPC---LENSS 499
Query: 526 YTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITN 585
++ E+ P ST + Q E++ + + L +
Sbjct: 500 PPSRIPEPESPAK--PNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSR 557
Query: 586 RPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRS 645
R + GVT T + EK L P R + + S R
Sbjct: 558 R----STQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPD 613
Query: 646 TQGVTLTDLQEAERTFSRSRAERQAQE-QPREKPTDTEGLEGSPEKHEPSAVPATEAGEG 704
QG +E + R + +E +P ++ ++ LEG P
Sbjct: 614 GQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSAR------------- 660
Query: 705 QQPWGRSLDEEP 716
+Q W R L+ EP
Sbjct: 661 RQRWQRDLNPEP 672
Score = 120 bits (301), Expect = 6e-27
Identities = 121/417 (29%), Positives = 184/417 (44%), Gaps = 48/417 (11%)
Query: 589 PSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQG 648
P T NGV++ P S EA RR L A RR+ +G
Sbjct: 391 PRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGA---------LGPPERRTAEG 441
Query: 649 VTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPW 708
LQ + + QA+E + T T SP+ EPS + E +P
Sbjct: 442 APGAGLQRSASSSWLEGTSTQAKELRLARITPTP----SPKLPEPSVL-----SEVTKP- 491
Query: 709 GRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSES------ 762
L+ R+ P P KP P + ST+ P+ S + + V D ES
Sbjct: 492 PPCLENSSPPSRIPEPESPAKPNVPTA-STAPPA--DSRDRRRSYQMPVRDEESESQRKA 548
Query: 763 -------SETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKE---RRRGTGINF 812
S +T T ++ + E E S+ RRP+ +
Sbjct: 549 RSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQR 608
Query: 813 WTKDEDETDGSEEVKETWHERLSRLESG---GSNPTTSDSYGDRASAR----ARREAREA 865
+ + G + +E H ++ + G G +D + ++ ARR+ +
Sbjct: 609 AEAPDGQGPGPQAARE--HRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQR 666
Query: 866 RLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKT 925
L E+ + ++ LY EN++L+ L E L LA +K +LE+ A Q+QE+
Sbjct: 667 DLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELER-ATQRQERF 725
Query: 926 SDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIRVISKLSK 982
++R ++LE+E+ ERRALERK +E+EEE+K L++L++DNQRLKDEN ALIRVISKLSK
Sbjct: 726 AERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK 782
>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
16A [Homo sapiens]
Length = 528
Score = 206 bits (524), Expect = 9e-53
Identities = 132/404 (32%), Positives = 207/404 (51%), Gaps = 18/404 (4%)
Query: 10 KRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSP----RVRFEDGAVFLAA 65
+R + A+ RRA+Q++ W + E+E ++G G +P S +V F V L A
Sbjct: 21 ERLKHAQKRRAQQVKMW--AQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEA 78
Query: 66 CSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGW 125
+ D +EVR+ L G + N DGLTALHQ CID+ +MV+ L+E AN+N D+E W
Sbjct: 79 AARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW 138
Query: 126 TPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI--- 182
TPLHAAA+CG+L++ E I GA++ VN++G +P DL ++ D L + +GI
Sbjct: 139 TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQD 198
Query: 183 DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARS-GATALHVAAAKGYSEVLRLLIQAGY 241
+E +R E +ML D R L +G D+ GAT LHVAAA G+SE LL++
Sbjct: 199 SIEAARAVPELRMLDDIRSRLQAG--ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRA 256
Query: 242 ELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA--DEGLVEHLE 299
L+ +D DGW PLHAAA+WG +L D++ ++ + +TP DV +E + LE
Sbjct: 257 SLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLE 316
Query: 300 LLQKKQNVLRSEKETRNKL----IESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENK 355
L K +LR++ R+ L + K+ + LY ++ + + ++
Sbjct: 317 LKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPP 376
Query: 356 ESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSI 399
+S E+ + +E + PE H+ S +
Sbjct: 377 PTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV 420
>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
[Homo sapiens]
Length = 567
Score = 198 bits (504), Expect = 2e-50
Identities = 127/387 (32%), Positives = 197/387 (50%), Gaps = 17/387 (4%)
Query: 10 KRAESARMRRAEQLRRWRGSLTEQEPAER-RGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68
+R +A+ RRA+QL++W + EQ+ R R R+ T +V FE L A
Sbjct: 21 ERLRAAQKRRAQQLKKW--AQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLR 78
Query: 69 GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
D +EVR L + N DGLTALHQ CID ++VK L+ + ANVN +DNE WTPL
Sbjct: 79 NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLE--- 185
HAAA+CG++N+ + + +GA + VNS+G +P DL E+ D++ + QGI E
Sbjct: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN 198
Query: 186 QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV 245
+ R EQQM+ D + +G+ D A+ GAT LH+A A GY LL+ G ++V
Sbjct: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAAELLLDHGVRVDV 257
Query: 246 QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEG--LVEHLELLQK 303
+D+DGW PLHAAA WG + +L + R + + P D+ +E V LEL K
Sbjct: 258 KDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHK 317
Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFK--------NKEKMLYEEETPKSQEMEEENK 355
+++S+ ++ L ++ + + N + YE E Q E++
Sbjct: 318 HDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQRSAAEDQ 377
Query: 356 ESSSSSSEEEEGEDEASESETEKEADK 382
+S+ + + E + + +K
Sbjct: 378 RTSTYNGDIRETRTDQENKDPNPRLEK 404
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 127 bits (320), Expect = 4e-29
Identities = 88/297 (29%), Positives = 145/297 (48%), Gaps = 10/297 (3%)
Query: 9 GKRAESARMRRAEQLRRWRGSLTEQEPAERRGAG-RQPLTRRGSPRVRFEDGAVFLAACS 67
G+R + R EQ++ + E+E A ++ G + L +P+V F + A
Sbjct: 14 GQRQRLVKRMRCEQIKAYY----EREKAFQKQEGFLKRLKHAKNPKVHFNLTDMLQDAII 69
Query: 68 SGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTP 127
+ EV +LL GAD +T+ G + LH +N + + L++ NVN QD + WTP
Sbjct: 70 HHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTP 129
Query: 128 LHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA-EEPAMKDLLLEQVKKQGID--- 183
+H A +C +I + GA+V + + G +P D A E +LL + + G+D
Sbjct: 130 MHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTS 189
Query: 184 LEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYEL 243
L Q + + ML D + +L+SG + + G T LH+A A GY EV+ L+++ G +L
Sbjct: 190 LRQMKLQRPMSMLTDVKHFLSSGGNVNEKN-DEGVTLLHMACASGYKEVVSLILEHGGDL 248
Query: 244 NVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
N+ D WTPLH AA +G +L + + N + D+A +E + L
Sbjct: 249 NIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLL 305
Score = 73.9 bits (180), Expect = 7e-13
Identities = 39/118 (33%), Positives = 66/118 (55%), Gaps = 4/118 (3%)
Query: 73 EVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAA 132
+V+ L+ G ++N N +G+T LH AC ++V ++E+ ++N D++ WTPLH AA
Sbjct: 204 DVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAA 263
Query: 133 SCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKE 190
G N+ + + H A+ +VN E SD+A ++++LL K I E+ KE
Sbjct: 264 KYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLL----KAEIAWEEKMKE 317
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 110 bits (276), Expect = 5e-24
Identities = 73/236 (30%), Positives = 117/236 (49%), Gaps = 10/236 (4%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
L A D LLA GAD N V+ DG LH A + + + L+++ A V+ Q+
Sbjct: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI 182
EGWTPLH AA + N+A ++ A + +EG+ P +A L++ + QG
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVS-LVKLLTSQGA 518
Query: 183 DLEQSRKE--------EEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLR 234
+L+ ++ E+ ++ + L SG + D +SG LH AAA+G + +
Sbjct: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALD-QSGYGPLHTAAARGKYLICK 577
Query: 235 LLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
+L++ G L + + GWTPLH AA+ G E +LAE+ +M + TP +A
Sbjct: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Score = 78.2 bits (191), Expect = 4e-14
Identities = 65/227 (28%), Positives = 98/227 (43%), Gaps = 16/227 (7%)
Query: 75 RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
R L++R AD N +G T LH A ++ +VK L A ++ Q TPLH A
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
Query: 135 GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
G + ++ + GA ++ G P A K L+ + + + G LE +
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG-KYLICKMLLRYGASLELPTHQGWTP 596
Query: 195 MLQDARQWLNSGKIEDVR-----QARSGA------TALHVAAAKGYSEVLRLLIQAGYEL 243
+ A + G +E + A GA T LH+AA G V+ L+Q G +
Sbjct: 597 LHLAAYK----GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Query: 244 NVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
N + GWTPLH A + L E ++ RNK+G TP +A
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLA 699
Score = 70.5 bits (171), Expect = 7e-12
Identities = 57/213 (26%), Positives = 93/213 (43%), Gaps = 28/213 (13%)
Query: 92 LTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVG 151
+T LH +++ V+ L+ + +V+ Q G+TPL AA ++ + HGA
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 152 IVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDV 211
V+ +G P A + G D AR L+ G D
Sbjct: 423 RVDEDGWAPLHFAAQ-------------NGDD-------------GTARLLLDHGACVDA 456
Query: 212 RQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAE 271
Q R G T LH+AA + V RLL+ + N+ + +G TPLH AA++G +L
Sbjct: 457 -QEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515
Query: 272 ALCDMDIRNKLGQTPFDVA-DEGLVEHLELLQK 303
++D + + +TP +A + G V ++ L K
Sbjct: 516 QGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Score = 68.2 bits (165), Expect = 4e-11
Identities = 65/269 (24%), Positives = 120/269 (44%), Gaps = 19/269 (7%)
Query: 46 LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
++R+ P + +G L A G V+ L ++GA+++ + T LH A +
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
++ L+++ A + D G+ PLH AA+ G I + + +GAS+ + +G P LA
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
Query: 165 EEPAMKD---LLLEQVKKQGI-------DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQA 214
+ LL E G L + + E+ ++ L G + +
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL---LQCGADPNAAE- 656
Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
+SG T LH+A + + L++ ++ ++ GWTP H AA G +L EA
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716
Query: 275 DMDIRNKLGQTPFDVA----DEGLVEHLE 299
+D+++ + TP +A +G++ LE
Sbjct: 717 QLDVQDGVSCTPLQLALRSRKQGIMSFLE 745
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 106 bits (265), Expect = 9e-23
Identities = 94/317 (29%), Positives = 153/317 (48%), Gaps = 18/317 (5%)
Query: 6 HLGGKRAESARMR----RAEQL-RRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
H+ KR + ++ R Q+ + R LT A R G + + L RG+P + R +
Sbjct: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
Query: 58 DGAVFLAACSSGDTDE-VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G L + GD E V+ LL A ++ V +D LTALH A + + K L++ RAN
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
N + G+TPLH A + + E + +GAS+ + G P +A +++L
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Query: 177 VKK-QGIDLEQSRKEEEQQMLQDARQ------WLNSGKIEDVRQARSGATALHVAAAKGY 229
++ D+ R E M A Q L +G + D R AR T LH+A+ G
Sbjct: 430 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-AREEQTPLHIASRLGK 488
Query: 230 SEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
+E+++LL+Q + +G+TPLH +A G + S+L EA + K G TP V
Sbjct: 489 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548
Query: 290 ADE-GLVEHLELLQKKQ 305
A + G ++ +LL +++
Sbjct: 549 AAKYGSLDVAKLLLQRR 565
Score = 103 bits (258), Expect = 6e-22
Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 51/291 (17%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G V++LL RG+ +++ G TALH A + ++VK LV+ AN+N Q G
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD---LLLEQVKKQG 181
+TPL+ AA ++++ +Y + +GA+ +G P +A + +LLE K
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169
Query: 182 IDLE----QSRKEEEQQ---MLQD----------------------------------AR 200
+ L +RK++ + +LQ+ A
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229
Query: 201 QWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHW 260
LN G D AR+G T LHVA+ +G + +++LL+ G +++ + DG TPLH AA
Sbjct: 230 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
Query: 261 GVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE----LLQKKQNV 307
G + +L E + R K G +P +A +G +H+E LLQ K V
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--DHVECVKHLLQHKAPV 337
Score = 95.1 bits (235), Expect = 3e-19
Identities = 69/237 (29%), Positives = 110/237 (46%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL + A+ N ++G T LH AC + +++ LV+ A++ G
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
TP+H AA G+LNI + +GAS + N GE +A +++ ++ L
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA--L 468
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAAAKGYSEVL 233
+R EEQ L A + GK E V+ +G T LH++A +G +V
Sbjct: 469 VDARAREEQTPLHIASRL---GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
+L++AG ++ G+TPLH AA +G + +L + D K G TP VA
Sbjct: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582
Score = 92.8 bits (229), Expect = 1e-18
Identities = 109/451 (24%), Positives = 185/451 (41%), Gaps = 66/451 (14%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G D + LL R A ++ +GLT LH A +N + L+E A+ + G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA + IA +N+GA IV +G P LA + D++ + K G ++
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 667
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
S K SG T+LH+AA + V +L + G + +
Sbjct: 668 HMSTK--------------------------SGLTSLHLAAQEDKVNVADILTKHGADQD 701
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
G+TPL A H+G + + L + +++ + K G TP A +G + +L
Sbjct: 702 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL-- 759
Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSE 363
Q+ + T N + ++ + K++ EE T + + E++K + +
Sbjct: 760 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 819
Query: 364 E------EEGEDEAS---------ESETEKEADKKPEA-------FVNHSNSESKSSITE 401
E EEG+D + E E D P + ++ +S +S
Sbjct: 820 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 879
Query: 402 QIPAPAQNTFSASSARRFSSGLFNKPEEP--------KDESPSSWRLGLRKTGSHNMLSE 453
+ +T S +S R S+ + + P K+ +S+RL G+ N L
Sbjct: 880 SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRL---SWGTEN-LDN 935
Query: 454 VANSREPIRDRGSS--IYRSSSSPRISALLD 482
VA S PI +S + R +SS +S ++D
Sbjct: 936 VALSSSPIHSGRASPCLERDNSSFLVSFMVD 966
Score = 82.0 bits (201), Expect = 2e-15
Identities = 62/222 (27%), Positives = 90/222 (40%), Gaps = 27/222 (12%)
Query: 69 GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
G D LL GA + G T LH A +LD+ K L++ RA + G TPL
Sbjct: 520 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 579
Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSR 188
H AA +A + GAS G P +A
Sbjct: 580 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA------------------------ 615
Query: 189 KEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
++ +Q A LN G ++ + G T LH+A+ +G+++++ LL+ G +++
Sbjct: 616 --AKKNQMQIASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672
Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
G T LH AA IL + D D KLG TP VA
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714
Score = 80.9 bits (198), Expect = 5e-15
Identities = 63/239 (26%), Positives = 103/239 (43%), Gaps = 20/239 (8%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G+ + LL RGA ++ +G+T LH A N +MVK L++ ++ + +G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE----PAMKDLLLEQVKKQ 180
TPLH AA G+ + E + GA + G P +A + +K LL +
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Query: 181 GIDLE---------QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
+ L+ ++L D R N+ +A +G T LH+A K +
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA-------RALNGFTPLHIACKKNRIK 391
Query: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
V+ LL++ G + G TP+H AA G +L + D+ N G+T +A
Sbjct: 392 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
Score = 45.8 bits (107), Expect = 2e-04
Identities = 24/79 (30%), Positives = 40/79 (50%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ AC G+ V LL +GA++N +G T LHQA + ++ L+++ A N
Sbjct: 712 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 771
Query: 123 EGWTPLHAAASCGYLNIAE 141
G T L A GY+++ +
Sbjct: 772 NGNTALAIAKRLGYISVVD 790
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 106 bits (265), Expect = 9e-23
Identities = 94/317 (29%), Positives = 153/317 (48%), Gaps = 18/317 (5%)
Query: 6 HLGGKRAESARMR----RAEQL-RRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
H+ KR + ++ R Q+ + R LT A R G + + L RG+P + R +
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 58 DGAVFLAACSSGDTDE-VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G L + GD E V+ LL A ++ V +D LTALH A + + K L++ RAN
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
N + G+TPLH A + + E + +GAS+ + G P +A +++L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 177 VKK-QGIDLEQSRKEEEQQMLQDARQ------WLNSGKIEDVRQARSGATALHVAAAKGY 229
++ D+ R E M A Q L +G + D R AR T LH+A+ G
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-AREEQTPLHIASRLGK 509
Query: 230 SEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
+E+++LL+Q + +G+TPLH +A G + S+L EA + K G TP V
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
Query: 290 ADE-GLVEHLELLQKKQ 305
A + G ++ +LL +++
Sbjct: 570 AAKYGSLDVAKLLLQRR 586
Score = 103 bits (258), Expect = 6e-22
Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 51/291 (17%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G V++LL RG+ +++ G TALH A + ++VK LV+ AN+N Q G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD---LLLEQVKKQG 181
+TPL+ AA ++++ +Y + +GA+ +G P +A + +LLE K
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 182 IDLE----QSRKEEEQQ---MLQD----------------------------------AR 200
+ L +RK++ + +LQ+ A
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 201 QWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHW 260
LN G D AR+G T LHVA+ +G + +++LL+ G +++ + DG TPLH AA
Sbjct: 251 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309
Query: 261 GVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE----LLQKKQNV 307
G + +L E + R K G +P +A +G +H+E LLQ K V
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--DHVECVKHLLQHKAPV 358
Score = 95.1 bits (235), Expect = 3e-19
Identities = 69/237 (29%), Positives = 110/237 (46%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL + A+ N ++G T LH AC + +++ LV+ A++ G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
TP+H AA G+LNI + +GAS + N GE +A +++ ++ L
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA--L 489
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAAAKGYSEVL 233
+R EEQ L A + GK E V+ +G T LH++A +G +V
Sbjct: 490 VDARAREEQTPLHIASRL---GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
+L++AG ++ G+TPLH AA +G + +L + D K G TP VA
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Score = 89.0 bits (219), Expect = 2e-17
Identities = 103/428 (24%), Positives = 173/428 (40%), Gaps = 64/428 (14%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G D + LL R A ++ +GLT LH A +N + L+E A+ + G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA + IA +N+GA IV +G P LA + D++ + K G ++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 688
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
S K SG T+LH+AA + V +L + G + +
Sbjct: 689 HMSTK--------------------------SGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
G+TPL A H+G + + L + +++ + K G TP A +G + +L
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL-- 780
Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSE 363
Q+ + T N + ++ + K++ EE T + + E++K + +
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840
Query: 364 E------EEGEDEAS---------ESETEKEADKKPEA-------FVNHSNSESKSSITE 401
E EEG+D + E E D P + ++ +S +S
Sbjct: 841 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900
Query: 402 QIPAPAQNTFSASSARRFSSGLFNKPEEP--------KDESPSSWRLGLRKTGSHNMLSE 453
+ +T S +S R S+ + + P K+ +S+RL G+ N L
Sbjct: 901 SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRL---SWGTEN-LDN 956
Query: 454 VANSREPI 461
VA S PI
Sbjct: 957 VALSSSPI 964
Score = 82.0 bits (201), Expect = 2e-15
Identities = 62/222 (27%), Positives = 90/222 (40%), Gaps = 27/222 (12%)
Query: 69 GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
G D LL GA + G T LH A +LD+ K L++ RA + G TPL
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSR 188
H AA +A + GAS G P +A
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA------------------------ 636
Query: 189 KEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
++ +Q A LN G ++ + G T LH+A+ +G+++++ LL+ G +++
Sbjct: 637 --AKKNQMQIASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
G T LH AA IL + D D KLG TP VA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Score = 80.9 bits (198), Expect = 5e-15
Identities = 63/239 (26%), Positives = 103/239 (43%), Gaps = 20/239 (8%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G+ + LL RGA ++ +G+T LH A N +MVK L++ ++ + +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE----PAMKDLLLEQVKKQ 180
TPLH AA G+ + E + GA + G P +A + +K LL +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 181 GIDLE---------QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
+ L+ ++L D R N+ +A +G T LH+A K +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA-------RALNGFTPLHIACKKNRIK 412
Query: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
V+ LL++ G + G TP+H AA G +L + D+ N G+T +A
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Score = 45.8 bits (107), Expect = 2e-04
Identities = 24/79 (30%), Positives = 40/79 (50%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ AC G+ V LL +GA++N +G T LHQA + ++ L+++ A N
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792
Query: 123 EGWTPLHAAASCGYLNIAE 141
G T L A GY+++ +
Sbjct: 793 NGNTALAIAKRLGYISVVD 811
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 106 bits (265), Expect = 9e-23
Identities = 94/317 (29%), Positives = 153/317 (48%), Gaps = 18/317 (5%)
Query: 6 HLGGKRAESARMR----RAEQL-RRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
H+ KR + ++ R Q+ + R LT A R G + + L RG+P + R +
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 58 DGAVFLAACSSGDTDE-VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G L + GD E V+ LL A ++ V +D LTALH A + + K L++ RAN
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
N + G+TPLH A + + E + +GAS+ + G P +A +++L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 177 VKK-QGIDLEQSRKEEEQQMLQDARQ------WLNSGKIEDVRQARSGATALHVAAAKGY 229
++ D+ R E M A Q L +G + D R AR T LH+A+ G
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-AREEQTPLHIASRLGK 509
Query: 230 SEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
+E+++LL+Q + +G+TPLH +A G + S+L EA + K G TP V
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569
Query: 290 ADE-GLVEHLELLQKKQ 305
A + G ++ +LL +++
Sbjct: 570 AAKYGSLDVAKLLLQRR 586
Score = 103 bits (258), Expect = 6e-22
Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 51/291 (17%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G V++LL RG+ +++ G TALH A + ++VK LV+ AN+N Q G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD---LLLEQVKKQG 181
+TPL+ AA ++++ +Y + +GA+ +G P +A + +LLE K
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 182 IDLE----QSRKEEEQQ---MLQD----------------------------------AR 200
+ L +RK++ + +LQ+ A
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 201 QWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHW 260
LN G D AR+G T LHVA+ +G + +++LL+ G +++ + DG TPLH AA
Sbjct: 251 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309
Query: 261 GVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE----LLQKKQNV 307
G + +L E + R K G +P +A +G +H+E LLQ K V
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--DHVECVKHLLQHKAPV 358
Score = 95.1 bits (235), Expect = 3e-19
Identities = 69/237 (29%), Positives = 110/237 (46%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL + A+ N ++G T LH AC + +++ LV+ A++ G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
TP+H AA G+LNI + +GAS + N GE +A +++ ++ L
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA--L 489
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAAAKGYSEVL 233
+R EEQ L A + GK E V+ +G T LH++A +G +V
Sbjct: 490 VDARAREEQTPLHIASRL---GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
+L++AG ++ G+TPLH AA +G + +L + D K G TP VA
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Score = 89.0 bits (219), Expect = 2e-17
Identities = 103/428 (24%), Positives = 173/428 (40%), Gaps = 64/428 (14%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G D + LL R A ++ +GLT LH A +N + L+E A+ + G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA + IA +N+GA IV +G P LA + D++ + K G ++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 688
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
S K SG T+LH+AA + V +L + G + +
Sbjct: 689 HMSTK--------------------------SGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
G+TPL A H+G + + L + +++ + K G TP A +G + +L
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL-- 780
Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSE 363
Q+ + T N + ++ + K++ EE T + + E++K + +
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840
Query: 364 E------EEGEDEAS---------ESETEKEADKKPEA-------FVNHSNSESKSSITE 401
E EEG+D + E E D P + ++ +S +S
Sbjct: 841 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900
Query: 402 QIPAPAQNTFSASSARRFSSGLFNKPEEP--------KDESPSSWRLGLRKTGSHNMLSE 453
+ +T S +S R S+ + + P K+ +S+RL G+ N L
Sbjct: 901 SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRL---SWGTEN-LDN 956
Query: 454 VANSREPI 461
VA S PI
Sbjct: 957 VALSSSPI 964
Score = 82.0 bits (201), Expect = 2e-15
Identities = 62/222 (27%), Positives = 90/222 (40%), Gaps = 27/222 (12%)
Query: 69 GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
G D LL GA + G T LH A +LD+ K L++ RA + G TPL
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSR 188
H AA +A + GAS G P +A
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA------------------------ 636
Query: 189 KEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
++ +Q A LN G ++ + G T LH+A+ +G+++++ LL+ G +++
Sbjct: 637 --AKKNQMQIASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
G T LH AA IL + D D KLG TP VA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Score = 80.9 bits (198), Expect = 5e-15
Identities = 63/239 (26%), Positives = 103/239 (43%), Gaps = 20/239 (8%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G+ + LL RGA ++ +G+T LH A N +MVK L++ ++ + +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE----PAMKDLLLEQVKKQ 180
TPLH AA G+ + E + GA + G P +A + +K LL +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 181 GIDLE---------QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
+ L+ ++L D R N+ +A +G T LH+A K +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA-------RALNGFTPLHIACKKNRIK 412
Query: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
V+ LL++ G + G TP+H AA G +L + D+ N G+T +A
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Score = 51.2 bits (121), Expect = 5e-06
Identities = 80/378 (21%), Positives = 148/378 (39%), Gaps = 33/378 (8%)
Query: 349 EMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQ 408
+M E+ +E S EE++ E +E + + ++ + + I + A
Sbjct: 2721 KMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGHGCEAM 2780
Query: 409 NTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSE-----VANSREPIRD 463
+ +SSA SSGL + + DE P ++ L G+H +E V+ + P D
Sbjct: 2781 SP--SSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAESPQAD 2838
Query: 464 RGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRS 523
S + SSSS + + K+ + E+ S SS+ ++ T + E ++ +
Sbjct: 2839 CPSESFSSSSSLPHCLVSEGKELD-EDISATSSIQKTEVTKTDETFENLPKDCP---SQD 2894
Query: 524 GSYTRQLWR--------DEAKGNEI--PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADN 573
S T Q R D A+ +EI PQ +P V + + +S+ T A T
Sbjct: 2895 SSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSF 2954
Query: 574 VSSSTPLCVITNR----PLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAE 629
SS IT+ + S+++G + + G D +E++++ + D +
Sbjct: 2955 HSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLW-EMQSDSVSS 3013
Query: 630 SLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQE-QPREKPTDTEGL---- 684
S S V +T ++S R + +A E + +E+ GL
Sbjct: 3014 SFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDR 3073
Query: 685 --EGSPEKHEPSAVPATE 700
+G+ P+ P E
Sbjct: 3074 QSQGTTPDTTPARTPTEE 3091
Score = 45.8 bits (107), Expect = 2e-04
Identities = 24/79 (30%), Positives = 40/79 (50%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ AC G+ V LL +GA++N +G T LHQA + ++ L+++ A N
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792
Query: 123 EGWTPLHAAASCGYLNIAE 141
G T L A GY+++ +
Sbjct: 793 NGNTALAIAKRLGYISVVD 811
Score = 42.4 bits (98), Expect = 0.002
Identities = 124/669 (18%), Positives = 241/669 (36%), Gaps = 113/669 (16%)
Query: 299 ELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESS 358
E L+K +LRS TR++ S +QS +++ ++ EE S E EE ++ +
Sbjct: 1557 EDLEKVNEILRSGTCTRDE-------SSVQSS--RSERGLVEEEWVIVSDEEIEEARQKA 1607
Query: 359 SSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARR 418
E + + E + + +K VN+ + + + +P T + ++
Sbjct: 1608 PLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVP--LPKEQLQTVQDKAGKK 1665
Query: 419 FSSGLFNKPEE------PKDESPSSWR-----LGLRKTGSHNMLSEVANSREPIRDRGSS 467
+ + E P DE+ S+ + LG++K + +E + +
Sbjct: 1666 CEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKL-------KEKQKQKEEG 1718
Query: 468 IYRSSSSPRISALLDNKDKERENKSYISSLAPRKL---NSTSDIEEKENRESAVNLVRSG 524
+ S+ + K E+ LAP L +TS + E+ S + V++
Sbjct: 1719 LQASAEKAELK-----KGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKA- 1772
Query: 525 SYTRQLWRDEAKG-NEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVI 583
++ DE KG +++P + V PH + + + K+ + S
Sbjct: 1773 --LQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSL--KSERHAPGSPSPKTE 1828
Query: 584 TNRPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTR 643
+ L S+A PV S ++ ++ S ++P E S + S+ + +
Sbjct: 1829 RHSTLSSSAKTERHPPV--------SPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSP 1880
Query: 644 RSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLE--GSPEKHEPSAVPATEA 701
S T E S ++ ER P K + G EKH P + TE
Sbjct: 1881 VSPSTKT-----ERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEK 1935
Query: 702 GEGQQPWGRSLDEEPIC-------HRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNR 754
P GR+ +P+ H P+ + P SP++ + + + +
Sbjct: 1936 RLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMK 1995
Query: 755 FSVPDSESSETTTNT---TTAKEMDKNENEEADLDEQSSKRLSIRERRRPK--------- 802
+ S+ T +AK+ E + ++++ L+ RE ++ +
Sbjct: 1996 AFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQR 2055
Query: 803 -------ERRRGTGI-NFWTKDEDETDGSEEV--------KETWHERLSRLESGGSNPTT 846
E +RG + + K ED G E+V ++ E S ES
Sbjct: 2056 LPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKM 2115
Query: 847 SDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQK-----LKTKLQ 901
+D GD L + ++ D+ ++ + L +N K L + +
Sbjct: 2116 ADEQGD---------------MDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETE 2160
Query: 902 EAQLELADI 910
+AQL L +
Sbjct: 2161 KAQLHLDQV 2169
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 106 bits (265), Expect = 9e-23
Identities = 68/237 (28%), Positives = 113/237 (47%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL + A+ N ++G T LH AC + +++ L+++ A++ G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
TP+H AA G++NI ++HGAS N GE +A + ++ + + G +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE-VVRYLVQDGAQV 492
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQ-----------ARSGATALHVAAAKGYSEVL 233
E K+++ + AR GK + V+Q SG T LH++A +G+ +V
Sbjct: 493 EAKAKDDQTPLHISAR----LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
L+ G L++ G+TPLH AA +G E ++L + D K G TP VA
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA 605
Score = 101 bits (252), Expect = 3e-21
Identities = 78/274 (28%), Positives = 130/274 (47%), Gaps = 39/274 (14%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + V +LL R A+++ G TALH A + ++VK LV N ANVN Q G
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNG 140
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA---MKDLLLEQVKKQG 181
+TPL+ AA +L + ++ +++GAS + +G P +A + + LLLE K
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGK 200
Query: 182 IDLE----QSRKEEEQQ---MLQD--------------------------ARQWLNSGKI 208
+ L +RK++ + +LQ+ A LN
Sbjct: 201 VRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAA 260
Query: 209 EDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSI 268
D AR+ T LHVA+ +G + +++LL+ G +++ + DG TPLH A G ++ +
Sbjct: 261 VDF-TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319
Query: 269 LAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQ 302
L + + + K G +P +A +G +HL +Q
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMATQG--DHLNCVQ 351
Score = 98.2 bits (243), Expect = 3e-20
Identities = 70/264 (26%), Positives = 123/264 (46%), Gaps = 8/264 (3%)
Query: 32 EQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDG 91
E+EP ++R ++ R+ + + A +L A +G ++ + G DIN N +G
Sbjct: 19 EEEPEKKRKHRKRSRDRKK----KSDANASYLRAARAGHLEKALDYIKNGVDINICNQNG 74
Query: 92 LTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVG 151
L ALH A + ++++V L++ ANV+ +G T LH A+ G + + + +GA+V
Sbjct: 75 LNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN 134
Query: 152 IVNSEGEVPSDLAEEP---AMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKI 208
+ G P +A + + LL+ Q + E LQ + S +
Sbjct: 135 AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG-FTPLAVALQQGHDQVVSLLL 193
Query: 209 EDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSI 268
E+ + + ALH+AA K ++ LL+Q +V+ G+TPLH AAH+G ++
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATL 253
Query: 269 LAEALCDMDIRNKLGQTPFDVADE 292
L +D + TP VA +
Sbjct: 254 LLNRAAAVDFTARNDITPLHVASK 277
Score = 95.1 bits (235), Expect = 3e-19
Identities = 88/320 (27%), Positives = 144/320 (45%), Gaps = 26/320 (8%)
Query: 6 HLGGKRAESARM-----RRAEQLRRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
H+ KR + + R A+ + R LT R G + + L R +P + + +
Sbjct: 273 HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
Query: 58 DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G L + GD + V+ LL ++ V D LTALH A + + K L++ +AN
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
N + G+TPLH A + + E + HGAS+ V G P +A + ++ Q
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN-IVSQ 451
Query: 177 VKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAA 225
+ G + E + AR SG+ E VR +A+ T LH++A
Sbjct: 452 LMHHGASPNTTNVRGETALHMAAR----SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507
Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
G +++++ L+Q G N G+TPLH +A G ++ + L + + I K G T
Sbjct: 508 RLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFT 567
Query: 286 PFDVADE-GLVEHLELLQKK 304
P VA + G +E LL +K
Sbjct: 568 PLHVAAKYGKLEVANLLLQK 587
Score = 89.0 bits (219), Expect = 2e-17
Identities = 70/253 (27%), Positives = 103/253 (40%), Gaps = 35/253 (13%)
Query: 38 RRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQ 97
+ GA Q +T G + A G + V +L+ GA NT NV G TALH
Sbjct: 421 KHGASIQAVTESGLTPIH--------VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472
Query: 98 ACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEG 157
A ++V++LV++ A V + + TPLH +A G +I + + GAS + G
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
Query: 158 EVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSG 217
P L+ +D+ A L+ G + + G
Sbjct: 533 YTPLHLSAREGHEDV--------------------------AAFLLDHGASLSI-TTKKG 565
Query: 218 ATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMD 277
T LHVAA G EV LL+Q + G TPLH AAH+ ++ +L +
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625
Query: 278 IRNKLGQTPFDVA 290
K G TP +A
Sbjct: 626 AAAKNGYTPLHIA 638
Score = 88.2 bits (217), Expect = 3e-17
Identities = 64/231 (27%), Positives = 106/231 (45%), Gaps = 14/231 (6%)
Query: 69 GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
G D V++LL +GA N G T LH + + + D+ FL+++ A+++ +G+TPL
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA---EEPAMKDLLLEQ-------VK 178
H AA G L +A + AS G P +A + + LLL+Q K
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629
Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
L + K+ + + A L G + R G ++H+AA +G+ +++ LL+
Sbjct: 630 NGYTPLHIAAKKNQMDI---ATTLLEYGADANA-VTRQGIASVHLAAQEGHVDMVSLLLG 685
Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
+N+ + G TPLH AA +L +D + K+G TP V
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736
Score = 73.6 bits (179), Expect = 9e-13
Identities = 60/217 (27%), Positives = 88/217 (40%), Gaps = 28/217 (12%)
Query: 46 LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
L + SP ++G L A D LL GAD N V G+ ++H A + ++
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
DMV L+ ANVN + G TPLH AA +N+AE +N GA V G P +
Sbjct: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
+K L+ S K + ++G T LH A
Sbjct: 738 -------CHYGNIKIVNFLLQHSAKVN--------------------AKTKNGYTPLHQA 770
Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG 261
A +G++ ++ +L+Q N +G T L A G
Sbjct: 771 AQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 807
Score = 68.2 bits (165), Expect = 4e-11
Identities = 39/121 (32%), Positives = 55/121 (45%), Gaps = 8/121 (6%)
Query: 40 GAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQAC 99
GA +TR+G V A G D V LL R A++N N GLT LH A
Sbjct: 654 GADANAVTRQGIASVHL--------AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705
Query: 100 IDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEV 159
++ +++ + LV A+V+ Q G+TPLH G + I + + H A V G
Sbjct: 706 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYT 765
Query: 160 P 160
P
Sbjct: 766 P 766
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 106 bits (264), Expect = 1e-22
Identities = 94/326 (28%), Positives = 155/326 (47%), Gaps = 16/326 (4%)
Query: 64 AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE 123
AA S+G + V+ LL G +I+ +NV G TALH AC + +V L++ ANVNQ +N
Sbjct: 187 AAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
Query: 124 GWTPLH-AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI 182
G+TPLH AAAS E +N+GA V I + +G+ P + + + + + G
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG-RFTRSQTLIQNGG 305
Query: 183 DLEQSRKEEEQQMLQDARQ----WLNSGKIEDVRQARSGATA---LHVAAAKGYSEVLRL 235
+++ K+ + AR +N+ + A+ G + LH+AA +S+ R
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
L+ +G+E++ D G T LHAAA G E +L + D ++K G+TP A
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 296 EHL--ELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEE 353
H L+ NV ++ R + L+ S +NK + + + E E
Sbjct: 426 FHCIETLVTTGANVNETDDWGR-----TALHYAAASDMDRNKTILGNAHDNSEELERARE 480
Query: 354 NKESSSSSSEEEEGEDEASESETEKE 379
KE ++ E +++A+ S +KE
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKE 506
Score = 95.9 bits (237), Expect = 2e-19
Identities = 74/245 (30%), Positives = 126/245 (51%), Gaps = 12/245 (4%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A + +D RKLL+ G +I+T + G T LH A N++ +K L + A+ +++D G
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAM--KDLLLEQVKKQGI 182
TPLH AA+ + + E + GA+V + G A M +L
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
Query: 183 DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ---A 239
+LE++R+ +E++ L + +R + G ++H AAA G+ + L LL++ +
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDANPSIRD-KEGYNSIHYAAAYGHRQCLELLLERTNS 532
Query: 240 GYELNVQDYDGWT--PLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVE 296
G+E + G T PLH AA+ G +A +L ++L D+DIR++ G+T D+A +G E
Sbjct: 533 GFE---ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTE 589
Query: 297 HLELL 301
+E L
Sbjct: 590 CVEAL 594
Score = 94.7 bits (234), Expect = 4e-19
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 28/227 (12%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A +G + V LLA+GA+IN + ALH A +LD+V L+ + A V +D +G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLHAAAS G +N+ ++ +N G + +N G +A +D ++ ++ G ++
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG-QDAVVNELIDYGANV 240
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV-LRLLIQAGYEL 243
Q +G T LH AAA + + L LL+ G ++
Sbjct: 241 NQPN--------------------------NNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 244 NVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
N+Q DG +PLH A G L + ++D +K G TP VA
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVA 321
Score = 75.1 bits (183), Expect = 3e-13
Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 33/225 (14%)
Query: 69 GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
GD + + L+ GA +N + LT LH+A + + V+ L+++ A+VN +D TPL
Sbjct: 27 GDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPL 86
Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVP---SDLAEEPAMKDLLLEQVKKQGIDLE 185
H AA+ + AE I +SV + + G + L M +LLL +G ++
Sbjct: 87 HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL----AKGANIN 142
Query: 186 QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV 245
K++ + ALH AA G+ +V+ LLI G E+
Sbjct: 143 AFDKKDRR--------------------------ALHWAAYMGHLDVVALLINHGAEVTC 176
Query: 246 QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
+D G+TPLHAAA G L ++D N G T +A
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
Score = 65.1 bits (157), Expect = 3e-10
Identities = 57/232 (24%), Positives = 105/232 (45%), Gaps = 13/232 (5%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A +S + V+ L+ AD+N + + T LH A ++ + + ++ ++VN D G
Sbjct: 56 AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
T LH AA G++ + + GA++ + + A D++ + G ++
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI-NHGAEV 174
Query: 185 EQSRKE--------EEQQMLQDARQWLNSG-KIEDVRQARSGATALHVAAAKGYSEVLRL 235
K+ + + LN G +I+++ G TALH+A G V+
Sbjct: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINV--YGNTALHIACYNGQDAVVNE 232
Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEAC-SILAEALCDMDIRNKLGQTP 286
LI G +N + +G+TPLH AA C +L D++I++K G++P
Sbjct: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284
Score = 61.2 bits (147), Expect = 4e-09
Identities = 70/283 (24%), Positives = 119/283 (42%), Gaps = 41/283 (14%)
Query: 64 AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE 123
AA + G+ + ++ L + GAD + + G T LH A + + ++ LV ANVN+ D+
Sbjct: 386 AAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDW 445
Query: 124 GWTPLHAAASCGYLN----------------------------IAEYFINHGASVGIVNS 155
G T LH AA+ E+ + + A+ I +
Sbjct: 446 GRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDK 505
Query: 156 EGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQA- 214
EG A + L +++ E+S + L A + +E + Q+
Sbjct: 506 EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSL 565
Query: 215 -------RSGATALHVAAAKGYSEVLRLLIQAGYELNVQD-YDGWTPLHAAAHWGVKEAC 266
G TAL +AA KG++E + LI G + V+D TPLHA+ G
Sbjct: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625
Query: 267 SILAEALCD---MDIRNKLGQTPFDVA-DEGLVEHLELLQKKQ 305
+L E + +D+++ GQTP +A G ++ + LL +K+
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Score = 58.9 bits (141), Expect = 2e-08
Identities = 64/241 (26%), Positives = 109/241 (45%), Gaps = 15/241 (6%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ A + G D V LL + A+++TV++ G TALH+ + + + V+ L+E ++ +D+
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGAS---VGIVNSEGEVPSDLA----EEPAMKDLLLE 175
G TPLH AA+ G+ + S +++G P A E ++ LL +
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Query: 176 QVKKQGI-----DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
+ ++ I L + + ++S I R + G T L AA +
Sbjct: 770 KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDS-SIVSCRDDK-GRTPLRAAAFADHV 827
Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILA-EALCDMDIRNKLGQTPFDV 289
E L+LL++ +N D G T L AA G A IL A D+ +++K TP +
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887
Query: 290 A 290
A
Sbjct: 888 A 888
Score = 54.7 bits (130), Expect = 4e-07
Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 13/223 (5%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN-E 123
A +G + LL D++ + G TAL A + + V+ L+ A++ +DN
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 124 GWTPLHAAASCGY---LNIAEYFINHGASVGIVNSEGEVPSDLA----EEPAMKDLLLEQ 176
TPLHA+ G+ L + ++ +V + +++G+ P LA A+ LL ++
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 177 VKKQGIDLEQSRKEEEQQML--QDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLR 234
+D+ M ++ Q L ++ + + G T LH AAA+G++ L
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
Query: 235 LLIQAGY---ELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
L+Q + +D G+TPLH A + G + +L E C
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
Score = 54.3 bits (129), Expect = 5e-07
Identities = 35/85 (41%), Positives = 47/85 (55%), Gaps = 1/85 (1%)
Query: 207 KIEDVRQARSGA-TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEA 265
K EDV S T LHVAA G +E++ LLI +G +N +D TPLH A +EA
Sbjct: 5 KTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEA 64
Query: 266 CSILAEALCDMDIRNKLGQTPFDVA 290
+L + D++ R+K QTP VA
Sbjct: 65 VQVLIKHSADVNARDKNWQTPLHVA 89
Score = 43.9 bits (102), Expect = 7e-04
Identities = 62/246 (25%), Positives = 92/246 (37%), Gaps = 36/246 (14%)
Query: 64 AACSSGDTDEVRKLLARGADINTVNVD---GLTALHQACIDENLDMVKFLVENRANVNQQ 120
A+ +G T +R LL + V+V G T L A ++D V L+E ANV+
Sbjct: 615 ASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTV 674
Query: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
D G T LH G+ + + S+ +S G P A L E
Sbjct: 675 DILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE----- 729
Query: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
L Q EE +D G T LH A G + +L++
Sbjct: 730 ---LLQMALSEEDCCFKD----------------NQGYTPLHWACYNGNENCIEVLLE-- 768
Query: 241 YELNVQDYDG--WTPLHAAAHWGVKEACSILAEALCD--MDIRNKLGQTPFDVADEGLVE 296
+ + + G +TPLH A S+L A+ + R+ G+TP A +
Sbjct: 769 -QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA--AFAD 825
Query: 297 HLELLQ 302
H+E LQ
Sbjct: 826 HVECLQ 831
Score = 37.4 bits (85), Expect = 0.070
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 2/104 (1%)
Query: 55 RFEDGAVFLAACSSGDTDEVRKLLAR-GADINTVNVDGLTALHQACIDENLDMVKFLVEN 113
R + G L A + D E +LL R A +N V+ G TAL A + V LV +
Sbjct: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
Query: 114 -RANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSE 156
+A++ +D + TPLH A S G+ A ++ ++N +
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 102 bits (253), Expect = 2e-21
Identities = 87/292 (29%), Positives = 129/292 (44%), Gaps = 37/292 (12%)
Query: 44 QPLTRRGSPRVRFED----GAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQAC 99
Q L +RGS R+ +D AV+ AA G D ++ L ++ + G ALH A
Sbjct: 396 QLLIKRGS-RIDVQDKGGSNAVYWAA-RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 100 IDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEV 159
+ D+ + L +N N QD E TPLH AA GY ++A+ G +V I N EGE
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGET 513
Query: 160 PSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGAT 219
P A D++ E + + G DL K+ G
Sbjct: 514 PLLTASARGYHDIV-ECLAEHGADLNACDKD--------------------------GHI 546
Query: 220 ALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIR 279
ALH+A + EV++ L+ G ++ QD G TPLH A G L EA C++DI
Sbjct: 547 ALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDIS 606
Query: 280 NKLGQTPFDVADEG----LVEHLELLQKKQNVLRSEKETRNKLIESDLNSKI 327
NK G+TP +A +V +L L+ L ++ +T L S+ + +
Sbjct: 607 NKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHV 658
Score = 78.2 bits (191), Expect = 4e-14
Identities = 57/197 (28%), Positives = 90/197 (45%), Gaps = 29/197 (14%)
Query: 92 LTALHQACIDENLDMVKFLVENRAN--VNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
+ A+ A D+N+ ++ L+ + +N VNQ + G PL AA CG + I + I G+
Sbjct: 345 MKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSR 404
Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
+ + + G A D L ++L+ K
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDTL---------------------------KFLSENKCP 437
Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
+ +SG ALHVAA G+++V +LL G N+QD + TPLH AA G L
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497
Query: 270 AEALCDMDIRNKLGQTP 286
EA C+++I+N+ G+TP
Sbjct: 498 CEAGCNVNIKNREGETP 514
Score = 64.3 bits (155), Expect = 5e-10
Identities = 40/126 (31%), Positives = 69/126 (54%), Gaps = 5/126 (3%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
++ LL++G ++ + G T LH AC D N+ +V L E N++ + G TPLH AA+
Sbjct: 560 IKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAAN 619
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--LLEQVKK---QGIDLEQSR 188
G L++ Y GASV + ++G+ DLA + + LL +++K +G+ ++Q R
Sbjct: 620 NGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLR 679
Query: 189 KEEEQQ 194
+ Q
Sbjct: 680 PTQNLQ 685
Score = 48.5 bits (114), Expect = 3e-05
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 5/110 (4%)
Query: 210 DVRQA-RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSI 268
DV Q + G L +AA G ++L+LLI+ G ++VQD G ++ AA G +
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 269 LAEALCDMDIRNKLGQTPFDVADE-GLVEHLELL---QKKQNVLRSEKET 314
L+E C +D+++K G+ VA G + +LL N+ E+ET
Sbjct: 431 LSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET 480
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 101 bits (252), Expect = 3e-21
Identities = 78/258 (30%), Positives = 127/258 (49%), Gaps = 30/258 (11%)
Query: 63 LAACSSGDTDEVRKLLAR-------------GADINTVNVDGLTALHQACIDENLDMVKF 109
+ A +GD V+KL+A+ ++N + DG +ALH A + +L+++
Sbjct: 8 ILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIAL 67
Query: 110 LVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAM 169
L+E +A V+ +D+ G PLH AA G L + A+V + +G++P LA +
Sbjct: 68 LLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGH 127
Query: 170 KDL------------LLEQVKKQGIDL--EQSRKEEEQQMLQD-ARQWLNSGKIEDVRQA 214
++ L+ + KK +DL E R + Q +L L G+ +D
Sbjct: 128 YEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDP 187
Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
+ T LH+AA G+ EV+R L++AG E+N Q G T LH AA +G E +L E
Sbjct: 188 -NYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGV 245
Query: 275 DMDIRNKLGQTPFDVADE 292
D++IRN QT D+ ++
Sbjct: 246 DVNIRNTYNQTALDIVNQ 263
Score = 79.0 bits (193), Expect = 2e-14
Identities = 69/241 (28%), Positives = 112/241 (46%), Gaps = 26/241 (10%)
Query: 54 VRFEDGAVFLA---ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFL 110
V ++D F A A G + + LL A ++ + +G+ LH A L+ V+ L
Sbjct: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
Query: 111 VENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMK 170
+ A VN +G PLH AA G+ ++E + H ++ +VN + P DLA E
Sbjct: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRL 161
Query: 171 DL------------LLEQVKKQGID------LEQSRKEEEQQMLQDARQWLNSGKIEDVR 212
+ LLE K D L + K ++++ RQ L +G IE R
Sbjct: 162 KVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI---RQLLRAG-IEINR 217
Query: 213 QARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEA 272
Q ++G TALH AA G +EV+RLL++ G ++N+++ T L + +A + +
Sbjct: 218 QTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQL 276
Query: 273 L 273
L
Sbjct: 277 L 277
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 101 bits (252), Expect = 3e-21
Identities = 81/278 (29%), Positives = 129/278 (46%), Gaps = 49/278 (17%)
Query: 77 LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
LL +GA+IN + LT LH A + D+V+ +V++ A VN DN G T LH AA CG+
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445
Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQML 196
L +++G I++ +G + E ++Q+ ++GI L S E ++Q+L
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNEN------VQQLLQEGISLGNS--EADRQLL 497
Query: 197 QDAR-------------QWLNSGKIE---------------------------DVR-QAR 215
+ A+ Q +N IE DV + +
Sbjct: 498 EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 557
Query: 216 SGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCD 275
G LH A + G+ EV LL++ G +NV D +TPLH AA G E C +L + D
Sbjct: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD 617
Query: 276 MDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKE 313
+N+ G TP D+ +G + +LL+ +L + K+
Sbjct: 618 PTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655
Score = 99.0 bits (245), Expect = 2e-20
Identities = 87/290 (30%), Positives = 132/290 (45%), Gaps = 32/290 (11%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G D V LL GA++ + GL LH AC + ++V L+ + A+ N +DN
Sbjct: 65 AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWN 124
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA G +++ + HGA I N++G DLA +P+ K +L + KK + L
Sbjct: 125 YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-DPSAKAVLTGEYKKDEL-L 182
Query: 185 EQSRKEEEQQML------------QDARQ--------WLNSGKI--------EDVRQARS 216
E +R E++M+ D R+ N KI DV
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242
Query: 217 G-ATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCD 275
G LH A + G+ EV LL++ G +N D +TPLH AA E CS+L D
Sbjct: 243 GDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302
Query: 276 MDIRNKLGQTPFDVA-DEGLVEHLELLQKKQNVLRSEKETRNKLIESDLN 324
+ N ++ D+A L E L K ++L++ +E I+ L+
Sbjct: 303 PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLS 352
Score = 94.7 bits (234), Expect = 4e-19
Identities = 78/245 (31%), Positives = 112/245 (45%), Gaps = 31/245 (12%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V LL GAD++ + GL LH AC + ++ + LV++ A VN D +TPLH AA+
Sbjct: 542 VEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAE--EPAMKDLL--------------LEQV 177
G I + + HGA N +G P DL + + ++DLL L +V
Sbjct: 602 KGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARV 661
Query: 178 KK------------QGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVR-QARSGATALHVA 224
KK QG L+ A L G DV Q + G LH A
Sbjct: 662 KKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG--ADVNAQDKGGLIPLHNA 719
Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQ 284
A+ G+ +V LLI+ +N D +TPLH AA G + C++L D ++N+ GQ
Sbjct: 720 ASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ 779
Query: 285 TPFDV 289
TP D+
Sbjct: 780 TPLDL 784
Score = 87.4 bits (215), Expect = 6e-17
Identities = 60/215 (27%), Positives = 108/215 (50%), Gaps = 9/215 (4%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V+ LL GAD++ + L LH AC + ++ + LV++ A VN D +TPLH AAS
Sbjct: 227 VQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAAS 286
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQ 193
+ + +++GA ++N + DLA P +K+ L + K G L Q+ +E +
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFK--GHSLLQAAREADV 344
Query: 194 QMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGY---SEVLRLLIQAGYELNVQDYDG 250
++ S ++ + + ++ TALH AAA Y ++ LL++ G +N + +
Sbjct: 345 TRIKKHL----SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEF 400
Query: 251 WTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
TPLH A+ + ++ + ++ + LGQT
Sbjct: 401 LTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQT 435
Score = 63.9 bits (154), Expect = 7e-10
Identities = 35/97 (36%), Positives = 48/97 (49%)
Query: 77 LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
LL GAD+N + GL LH A ++D+ L++ A VN D +TPLH AA G
Sbjct: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757
Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLL 173
+ + HGA + N EG+ P DL + LL
Sbjct: 758 TQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 46.6 bits (109), Expect = 1e-04
Identities = 51/168 (30%), Positives = 74/168 (44%), Gaps = 36/168 (21%)
Query: 95 LHQACIDENLDMVKFLVENRANVNQQDNEGW--TPLHAAASCGYLNIAEYFINHGASVGI 152
L +AC + +++ VK LV VN +D G TPLH AA G ++ EY + +GA+V
Sbjct: 28 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 153 VNSEGEVPSDLA---EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
+ G +P A + +LLL + G D +AR N
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLL----RHGAD-------------PNARDNWN----- 124
Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAA 257
T LH AA KG +V +L+Q G E +++ DG T L A
Sbjct: 125 --------YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 45.1 bits (105), Expect = 3e-04
Identities = 39/147 (26%), Positives = 69/147 (46%), Gaps = 4/147 (2%)
Query: 207 KIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEAC 266
K+ A +T LH AA G +V+ L+Q G + +D G PLH A +G E
Sbjct: 48 KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVV 107
Query: 267 SILAEALCDMDIRNKLGQTPF-DVADEGLVE-HLELLQKKQNVLRSEKETRNKLIESDLN 324
++L D + R+ TP + A +G ++ + LLQ + R L +D +
Sbjct: 108 NLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS 167
Query: 325 SK-IQSGFFKNKEKMLYEEETPKSQEM 350
+K + +G +K K+++L + ++M
Sbjct: 168 AKAVLTGEYK-KDELLESARSGNEEKM 193
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 97.8 bits (242), Expect = 4e-20
Identities = 72/238 (30%), Positives = 120/238 (50%), Gaps = 7/238 (2%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G D V LL GA+++ + GL LH AC + ++V L+ A+ N +DN
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA G +++ + HGA I N++G+ DLA +P+ K +L + KK + L
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA-DPSAKAVLTGEYKKDEL-L 340
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
E +R E++++ + D R+ +T LH+AA +++LL+Q G +++
Sbjct: 341 EAARSGNEEKLMALLTPLNVNCHASDGRK----STPLHLAAGYNRVRIVQLLLQHGADVH 396
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELL 301
+D G PLH A +G E +L + ++ + TP + A + VE LL
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
Score = 97.8 bits (242), Expect = 4e-20
Identities = 72/229 (31%), Positives = 118/229 (51%), Gaps = 11/229 (4%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V+ LL GAD++ + GL LH AC + ++ + L+++ A VN D +TPLH AAS
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQ 193
+ + ++HGA +VN G+ D+A P +++ L + K G L Q+ +E +
Sbjct: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFK--GHSLLQAAREAD- 501
Query: 194 QMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGY---SEVLRLLIQAGYELNVQDYDG 250
L ++ L + +I + +Q +S TALH A A + +V LL++ G +N ++ D
Sbjct: 502 --LAKVKKTL-ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDF 558
Query: 251 WTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE 299
TPLH AA + +L + M+ + LGQT A L HL+
Sbjct: 559 MTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA--ALAGHLQ 605
Score = 97.4 bits (241), Expect = 6e-20
Identities = 74/244 (30%), Positives = 113/244 (46%), Gaps = 27/244 (11%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V LL GAD++ + GL LH AC + ++ + LV + A+VN D +TPLH AA+
Sbjct: 700 VEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAA 759
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE--PAMKDL------LLEQVKKQGIDLE 185
G I + + HGA N +G P DL +E ++DL LL+ KK +
Sbjct: 760 KGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARV 819
Query: 186 QSRKEEEQQMLQDAR-------------------QWLNSGKIEDVRQARSGATALHVAAA 226
Q E +D + ++L + Q + G LH AA+
Sbjct: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAAS 879
Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
G+ ++ LLI+ +N D +TPLH AA G + C++L D ++N+ GQTP
Sbjct: 880 YGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939
Query: 287 FDVA 290
D+A
Sbjct: 940 LDLA 943
Score = 93.6 bits (231), Expect = 8e-19
Identities = 76/271 (28%), Positives = 129/271 (47%), Gaps = 35/271 (12%)
Query: 77 LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
LL +GA++N N D +T LH A + D+++ L ++ A +N D G T LH AA G+
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ--VKKQGID---LEQSRKEE 191
L +++G+ I++ +G + + E A++ +L E ++ +D LE S+ +
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNE-AVQQILSESTPIRTSDVDYRLLEASKAGD 662
Query: 192 EQQMLQ-DARQWLNSGKIE---------------------------DVR-QARSGATALH 222
+ + Q + Q +N +E DV + + G LH
Sbjct: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
Query: 223 VAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKL 282
A + G+ EV LL++ G +NV D +TPLH AA G E C +L + D +N+
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782
Query: 283 GQTPFDVADEGLVEHLELLQKKQNVLRSEKE 313
G TP D+ EG + +LL+ +L + K+
Sbjct: 783 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKK 813
Score = 66.2 bits (160), Expect = 1e-10
Identities = 35/106 (33%), Positives = 54/106 (50%)
Query: 77 LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
LL GAD+N + GL LH A ++D+ L++ VN D +TPLH AA G
Sbjct: 856 LLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR 915
Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI 182
+ + HGA + N EG+ P DLA ++ LL++ + + +
Sbjct: 916 TQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEAL 961
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/111 (34%), Positives = 57/111 (51%), Gaps = 3/111 (2%)
Query: 217 GATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDM 276
G LH A + G++EV+ LL+ G + N +D +TPLH AA G + C +L + D
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
Query: 277 DIRNKLGQTPFDVADEGLVEHLELLQKKQNVL---RSEKETRNKLIESDLN 324
+IRN G++ D+AD L KK +L RS E + + + LN
Sbjct: 309 NIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLN 359
Score = 53.9 bits (128), Expect = 7e-07
Identities = 51/212 (24%), Positives = 74/212 (34%), Gaps = 38/212 (17%)
Query: 46 LTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLD 105
L P + DG L GDTD L A ++ L + + C EN+
Sbjct: 770 LKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI- 828
Query: 106 MVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAE 165
N TPLH AA L +AEY + HGA V + G +P A
Sbjct: 829 ----------NCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAA 878
Query: 166 EPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225
D+ +K + +W T LH AA
Sbjct: 879 SYGHVDIAALLIK-------------YNTCVNATDKW--------------AFTPLHEAA 911
Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAA 257
KG +++ LL+ G + +++ +G TPL A
Sbjct: 912 QKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 41.2 bits (95), Expect = 0.005
Identities = 34/122 (27%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 218 ATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMD 277
++ LH AA G +V+ L+Q G ++ +D G PLH A +G E S+L D +
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276
Query: 278 IRNKLGQTPF-DVADEGLVE-HLELLQKKQNVLRSEKETRNKLIESDLNSK-IQSGFFKN 334
R+ TP + A +G ++ + LLQ + + ++ L +D ++K + +G +K
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
Query: 335 KE 336
E
Sbjct: 337 DE 338
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A +G + VR+L+ GA++N + G T L+ A + +L++VKFL+EN AN N +G
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
+TPL A G+ N+ + IN+G + N + + L + D+L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202
Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
K G E L A+ LN G + ++G T LH+A+ +G ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257
Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
L+ G ++ + D TPLH AA G IL + + + K G +P +A +G
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315
Query: 296 EHLELLQ 302
+HL+ ++
Sbjct: 316 DHLDCVR 322
Score = 92.8 bits (229), Expect = 1e-18
Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V+ LL RGA N NV T LH A + ++ K+L++N+A VN + + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
G+ N+ + + + A+ + + G P +A + +L ++K+ ++K
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
E + +DA ++ ++ V+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
+G T LH+AA + EV R L+Q G N + G TPLH AA G E ++L
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
+ ++ NK G TP VA EG V ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 92.4 bits (228), Expect = 2e-18
Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)
Query: 6 HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
H+ +R +R R Q+ + + LT A R G R + L G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 58 DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G + + GD D VR LL A+I+ + +D LT LH A + + K L++ A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
N + G+TPLH A ++ + E + GAS+ V G P S + P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
L ++G S + E + AR ++L K + +A+ T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
G++ +++LL++ N+ G TPLH AA G E L E K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 286 PFDVADE-GLVEHLELLQKK 304
P VA + G V ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558
Score = 92.4 bits (228), Expect = 2e-18
Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G LL R A N +GLT LH A NLD+VK L+ + + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA + +A + +G S + +G P LA + +++ + KQ
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
+G + + +SG T LH+ A +G+ V +LI+ G ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
G+TPLH A+H+G + L + D++ + KLG +P A +G + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
N + S+ T + + + + +K +M + E + +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
+ E+E +E S +E + D E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842
Score = 90.5 bits (223), Expect = 7e-18
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)
Query: 57 EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+D A G T+ V+ LL A+ N G T LH A + +++ V L+E A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
+G+TPLH AA G + +AE + A G P +A D++
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
+ + G L + K+ + ++ + Q+ S E V+ G T LH+AA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644
Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
+G++E++ LL+ N+ + G TPLH A G +L + +D ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
VA G ++ ++ L + Q ++ + KL S L+ Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL +GA N+ ++G T LH AC ++ +++ L++ A+++ G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
TPLH A+ G+L I + + GAS + N + E P +A ++ LL+ K
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462
Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
++ +++Q L A + ++ ++ + + +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
L++ G+TPLH AA +G +L E + K G TP VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.8 bits (203), Expect = 1e-15
Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)
Query: 62 FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
FL A SG+ D+ L G DINT N +GL LH A + ++ MV L+ +
Sbjct: 16 FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
+G T LH AA G + +N+GA+V + +G P +A + + LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
Q + E LQ + + + I + + ALH+AA + +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
+V G+TPLH AAH+ +L ++ + G TP +A G V
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
+ LL + ++ ET+ K + L+ ++G + E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292
Score = 77.8 bits (190), Expect = 5e-14
Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)
Query: 46 LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
L R GSP +G L A + R LL G N +V G+T LH A + +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
+MV L+ +AN N + G TPLH A G++ +A+ I HG V G P +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
L+ ++L + + + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741
Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
A +G+++++ LL++ G N DG TPL A G +L + L
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
R +T ++ D E EL+ K S + + +L++ L+ ++S
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861
Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
+ E +S+E E+ +KE S E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)
Query: 90 DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
D T+ +A NLD + N ++N + G LH A+ G++ + ++
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66
Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
K+++LE K+
Sbjct: 67 --------------------KEIILETTTKK----------------------------- 77
Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
G TALH+AA G EV+R L+ G +N Q G+TPL+ AA E L
Sbjct: 78 -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
E + ++ + G TP VA E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A +G + VR+L+ GA++N + G T L+ A + +L++VKFL+EN AN N +G
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
+TPL A G+ N+ + IN+G + N + + L + D+L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202
Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
K G E L A+ LN G + ++G T LH+A+ +G ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257
Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
L+ G ++ + D TPLH AA G IL + + + K G +P +A +G
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315
Query: 296 EHLELLQ 302
+HL+ ++
Sbjct: 316 DHLDCVR 322
Score = 92.8 bits (229), Expect = 1e-18
Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V+ LL RGA N NV T LH A + ++ K+L++N+A VN + + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
G+ N+ + + + A+ + + G P +A + +L ++K+ ++K
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
E + +DA ++ ++ V+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
+G T LH+AA + EV R L+Q G N + G TPLH AA G E ++L
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
+ ++ NK G TP VA EG V ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 92.4 bits (228), Expect = 2e-18
Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)
Query: 6 HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
H+ +R +R R Q+ + + LT A R G R + L G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 58 DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G + + GD D VR LL A+I+ + +D LT LH A + + K L++ A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
N + G+TPLH A ++ + E + GAS+ V G P S + P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
L ++G S + E + AR ++L K + +A+ T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
G++ +++LL++ N+ G TPLH AA G E L E K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 286 PFDVADE-GLVEHLELLQKK 304
P VA + G V ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558
Score = 92.4 bits (228), Expect = 2e-18
Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G LL R A N +GLT LH A NLD+VK L+ + + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA + +A + +G S + +G P LA + +++ + KQ
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
+G + + +SG T LH+ A +G+ V +LI+ G ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
G+TPLH A+H+G + L + D++ + KLG +P A +G + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
N + S+ T + + + + +K +M + E + +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
+ E+E +E S +E + D E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842
Score = 90.5 bits (223), Expect = 7e-18
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)
Query: 57 EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+D A G T+ V+ LL A+ N G T LH A + +++ V L+E A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
+G+TPLH AA G + +AE + A G P +A D++
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
+ + G L + K+ + ++ + Q+ S E V+ G T LH+AA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644
Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
+G++E++ LL+ N+ + G TPLH A G +L + +D ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
VA G ++ ++ L + Q ++ + KL S L+ Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL +GA N+ ++G T LH AC ++ +++ L++ A+++ G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
TPLH A+ G+L I + + GAS + N + E P +A ++ LL+ K
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462
Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
++ +++Q L A + ++ ++ + + +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
L++ G+TPLH AA +G +L E + K G TP VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.8 bits (203), Expect = 1e-15
Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)
Query: 62 FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
FL A SG+ D+ L G DINT N +GL LH A + ++ MV L+ +
Sbjct: 16 FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
+G T LH AA G + +N+GA+V + +G P +A + + LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
Q + E LQ + + + I + + ALH+AA + +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
+V G+TPLH AAH+ +L ++ + G TP +A G V
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
+ LL + ++ ET+ K + L+ ++G + E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292
Score = 77.8 bits (190), Expect = 5e-14
Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)
Query: 46 LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
L R GSP +G L A + R LL G N +V G+T LH A + +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
+MV L+ +AN N + G TPLH A G++ +A+ I HG V G P +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
L+ ++L + + + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741
Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
A +G+++++ LL++ G N DG TPL A G +L + L
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
R +T ++ D E EL+ K S + + +L++ L+ ++S
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861
Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
+ E +S+E E+ +KE S E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)
Query: 90 DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
D T+ +A NLD + N ++N + G LH A+ G++ + ++
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66
Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
K+++LE K+
Sbjct: 67 --------------------KEIILETTTKK----------------------------- 77
Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
G TALH+AA G EV+R L+ G +N Q G+TPL+ AA E L
Sbjct: 78 -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
E + ++ + G TP VA E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A +G + VR+L+ GA++N + G T L+ A + +L++VKFL+EN AN N +G
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
+TPL A G+ N+ + IN+G + N + + L + D+L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202
Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
K G E L A+ LN G + ++G T LH+A+ +G ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257
Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
L+ G ++ + D TPLH AA G IL + + + K G +P +A +G
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315
Query: 296 EHLELLQ 302
+HL+ ++
Sbjct: 316 DHLDCVR 322
Score = 92.8 bits (229), Expect = 1e-18
Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V+ LL RGA N NV T LH A + ++ K+L++N+A VN + + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
G+ N+ + + + A+ + + G P +A + +L ++K+ ++K
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
E + +DA ++ ++ V+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
+G T LH+AA + EV R L+Q G N + G TPLH AA G E ++L
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
+ ++ NK G TP VA EG V ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 92.4 bits (228), Expect = 2e-18
Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)
Query: 6 HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
H+ +R +R R Q+ + + LT A R G R + L G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 58 DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G + + GD D VR LL A+I+ + +D LT LH A + + K L++ A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
N + G+TPLH A ++ + E + GAS+ V G P S + P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
L ++G S + E + AR ++L K + +A+ T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
G++ +++LL++ N+ G TPLH AA G E L E K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 286 PFDVADE-GLVEHLELLQKK 304
P VA + G V ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558
Score = 92.4 bits (228), Expect = 2e-18
Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G LL R A N +GLT LH A NLD+VK L+ + + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA + +A + +G S + +G P LA + +++ + KQ
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
+G + + +SG T LH+ A +G+ V +LI+ G ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
G+TPLH A+H+G + L + D++ + KLG +P A +G + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
N + S+ T + + + + +K +M + E + +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
+ E+E +E S +E + D E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842
Score = 90.5 bits (223), Expect = 7e-18
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)
Query: 57 EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+D A G T+ V+ LL A+ N G T LH A + +++ V L+E A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
+G+TPLH AA G + +AE + A G P +A D++
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
+ + G L + K+ + ++ + Q+ S E V+ G T LH+AA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644
Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
+G++E++ LL+ N+ + G TPLH A G +L + +D ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
VA G ++ ++ L + Q ++ + KL S L+ Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL +GA N+ ++G T LH AC ++ +++ L++ A+++ G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
TPLH A+ G+L I + + GAS + N + E P +A ++ LL+ K
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462
Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
++ +++Q L A + ++ ++ + + +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
L++ G+TPLH AA +G +L E + K G TP VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.8 bits (203), Expect = 1e-15
Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)
Query: 62 FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
FL A SG+ D+ L G DINT N +GL LH A + ++ MV L+ +
Sbjct: 16 FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
+G T LH AA G + +N+GA+V + +G P +A + + LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
Q + E LQ + + + I + + ALH+AA + +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
+V G+TPLH AAH+ +L ++ + G TP +A G V
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
+ LL + ++ ET+ K + L+ ++G + E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292
Score = 77.8 bits (190), Expect = 5e-14
Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)
Query: 46 LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
L R GSP +G L A + R LL G N +V G+T LH A + +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
+MV L+ +AN N + G TPLH A G++ +A+ I HG V G P +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
L+ ++L + + + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741
Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
A +G+++++ LL++ G N DG TPL A G +L + L
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
R +T ++ D E EL+ K S + + +L++ L+ ++S
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861
Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
+ E +S+E E+ +KE S E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)
Query: 90 DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
D T+ +A NLD + N ++N + G LH A+ G++ + ++
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66
Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
K+++LE K+
Sbjct: 67 --------------------KEIILETTTKK----------------------------- 77
Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
G TALH+AA G EV+R L+ G +N Q G+TPL+ AA E L
Sbjct: 78 -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
E + ++ + G TP VA E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A +G + VR+L+ GA++N + G T L+ A + +L++VKFL+EN AN N +G
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
+TPL A G+ N+ + IN+G + N + + L + D+L
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202
Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
K G E L A+ LN G + ++G T LH+A+ +G ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257
Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
L+ G ++ + D TPLH AA G IL + + + K G +P +A +G
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315
Query: 296 EHLELLQ 302
+HL+ ++
Sbjct: 316 DHLDCVR 322
Score = 92.8 bits (229), Expect = 1e-18
Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)
Query: 74 VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
V+ LL RGA N NV T LH A + ++ K+L++N+A VN + + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
G+ N+ + + + A+ + + G P +A + +L ++K+ ++K
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
E + +DA ++ ++ V+ A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
+G T LH+AA + EV R L+Q G N + G TPLH AA G E ++L
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
+ ++ NK G TP VA EG V ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 92.4 bits (228), Expect = 2e-18
Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)
Query: 6 HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
H+ +R +R R Q+ + + LT A R G R + L G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 58 DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+G + + GD D VR LL A+I+ + +D LT LH A + + K L++ A
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
N + G+TPLH A ++ + E + GAS+ V G P S + P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
L ++G S + E + AR ++L K + +A+ T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
G++ +++LL++ N+ G TPLH AA G E L E K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538
Query: 286 PFDVADE-GLVEHLELLQKK 304
P VA + G V ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558
Score = 92.4 bits (228), Expect = 2e-18
Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G LL R A N +GLT LH A NLD+VK L+ + + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
+TPLH AA + +A + +G S + +G P LA + +++ + KQ
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
+G + + +SG T LH+ A +G+ V +LI+ G ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
G+TPLH A+H+G + L + D++ + KLG +P A +G + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
N + S+ T + + + + +K +M + E + +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815
Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
+ E+E +E S +E + D E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842
Score = 90.5 bits (223), Expect = 7e-18
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)
Query: 57 EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
+D A G T+ V+ LL A+ N G T LH A + +++ V L+E A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
+G+TPLH AA G + +AE + A G P +A D++
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
+ + G L + K+ + ++ + Q+ S E V+ G T LH+AA
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644
Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
+G++E++ LL+ N+ + G TPLH A G +L + +D ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
VA G ++ ++ L + Q ++ + KL S L+ Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + LL +GA N+ ++G T LH AC ++ +++ L++ A+++ G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
TPLH A+ G+L I + + GAS + N + E P +A ++ LL+ K
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462
Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
++ +++Q L A + ++ ++ + + +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
L++ G+TPLH AA +G +L E + K G TP VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.8 bits (203), Expect = 1e-15
Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)
Query: 62 FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
FL A SG+ D+ L G DINT N +GL LH A + ++ MV L+ +
Sbjct: 16 FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
+G T LH AA G + +N+GA+V + +G P +A + + LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
Q + E LQ + + + I + + ALH+AA + +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
+V G+TPLH AAH+ +L ++ + G TP +A G V
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
+ LL + ++ ET+ K + L+ ++G + E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292
Score = 77.8 bits (190), Expect = 5e-14
Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)
Query: 46 LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
L R GSP +G L A + R LL G N +V G+T LH A + +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648
Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
+MV L+ +AN N + G TPLH A G++ +A+ I HG V G P +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
L+ ++L + + + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741
Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
A +G+++++ LL++ G N DG TPL A G +L + L
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
R +T ++ D E EL+ K S + + +L++ L+ ++S
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861
Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
+ E +S+E E+ +KE S E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901
Score = 50.4 bits (119), Expect = 8e-06
Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)
Query: 90 DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
D T+ +A NLD + N ++N + G LH A+ G++ + ++
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66
Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
K+++LE K+
Sbjct: 67 --------------------KEIILETTTKK----------------------------- 77
Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
G TALH+AA G EV+R L+ G +N Q G+TPL+ AA E L
Sbjct: 78 -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
E + ++ + G TP VA E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
>gi|56090539 dysferlin-interacting protein 1 [Homo sapiens]
Length = 154
Score = 95.5 bits (236), Expect = 2e-19
Identities = 56/140 (40%), Positives = 83/140 (59%), Gaps = 8/140 (5%)
Query: 35 PAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLL-ARGADINTVNVDGLT 93
P +RR R+ L R VRF + +FL GD ++V + + R + T++ GL
Sbjct: 13 PRQRR---RRMLADRS---VRFPNDVLFLDHIRQGDLEQVGRFIRTRKVSLATIHPSGLA 66
Query: 94 ALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIV 153
ALH+A + NL+ VK LV+ A+++Q+D GWTPLH A S GY +IA Y I+ GA
Sbjct: 67 ALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDIARYLISLGADRDAT 126
Query: 154 NSEGEVPSDLAEEPAMKDLL 173
N +G++PSDL +P K+L+
Sbjct: 127 NDDGDLPSDLI-DPDYKELV 145
Score = 57.8 bits (138), Expect = 5e-08
Identities = 33/107 (30%), Positives = 51/107 (47%)
Query: 196 LQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLH 255
L+ +++ + K+ SG ALH A G E ++LL++ G +++ +D GWTPLH
Sbjct: 43 LEQVGRFIRTRKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLH 102
Query: 256 AAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQ 302
A G + L D D N G P D+ D E +EL +
Sbjct: 103 IACSDGYPDIARYLISLGADRDATNDDGDLPSDLIDPDYKELVELFK 149
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 95.5 bits (236), Expect = 2e-19
Identities = 89/330 (26%), Positives = 139/330 (42%), Gaps = 37/330 (11%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A + G V+ LL G D++ + TALH+A + N +++ L+ +++QD +G
Sbjct: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
T LH A+ G+ A+ + GA+V N G LA + +
Sbjct: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHS-------------- 154
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
Q R L +G D++ +G T LHVAA + ++RLL+ A ++
Sbjct: 155 ------------QSTRVLLLAGSRADLKN-NAGDTCLHVAARYNHLSIIRLLLTAFCSVH 201
Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEHLELLQK 303
++ G T LH AA K+ IL EA D I N GQTP + A E LL K
Sbjct: 202 EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261
Query: 304 KQNVL-----RSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQE----MEEEN 354
VL RS ++ R +L E + + + +TP S++ EE
Sbjct: 262 APQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAR 321
Query: 355 KESSSSSSEEEEGEDEASESETEKEADKKP 384
+E S+S E +D +S + A P
Sbjct: 322 EEFLSASPEPRAKDDRRRKSRPKVSAFSDP 351
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 94.7 bits (234), Expect = 4e-19
Identities = 134/598 (22%), Positives = 237/598 (39%), Gaps = 99/598 (16%)
Query: 63 LAACSSGDTDEVRKLLARGADINT-VNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
+ A +G V+ LL G+DIN + + TAL AC ++V L++ +ANV +
Sbjct: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254
Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQG 181
G TPL AAS GY + ++ GA V + P+ +D L +G
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADV-----------NAPPVPSSRDTALTIAADKG 1303
Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGY 241
+ ++ G DVR + G T L +A+ G+ +V++LL+QAG
Sbjct: 1304 -------------HYKFCELLIHRGAHIDVRN-KKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 242 ELNVQDYDGWTPLHAAAHWG--------VKEA--------CSILAEALCDMDIRNKLGQ- 284
+++ D TPL +A G VKE C + D ++ K Q
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQC 1409
Query: 285 --TPFDVADEGLVE---HLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
T D+ E + +L K+ ++ +S +E+R + + + + + K K+K
Sbjct: 1410 VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE----KRKKK-- 1463
Query: 340 YEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN---SESK 396
+EE + QE +EENK +S E+E E+E ++ + E+E +P + + S +
Sbjct: 1464 -KEEQKRKQEEDEENKPKENSELPEDEDEEE-NDEDVEQEVPIEPPSATTTTTIGISATS 1521
Query: 397 SSITEQIPAPAQNTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVAN 456
++ T N + S R NK + K+ P++ L H L++
Sbjct: 1522 ATFTNVFGKKRANVVTTPSTNR-----KNKKNKTKETPPTA---HLILPEQHMSLAQQKA 1573
Query: 457 SREPI--RDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKE-- 512
+ I RG +S S DN D N S ++LN D+ +
Sbjct: 1574 DKNKINGEPRGGGAGGNSDS-------DNLDSTDCNSESSSGGKSQELNFVMDVNSSKYP 1626
Query: 513 -----NRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTA 567
++E + S + TR +G P +++ S Y + L + + + T+
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTR------LEGEVTPNSLSTS-YKTVSLPLSSPNIKLNLTS 1679
Query: 568 EKTADNVSSSTPLCVITNRPLPSTAN---------GVTATPVLSITGTDSSVEAREKR 616
K V ++ L A+ G T + +TG V+ ++ +
Sbjct: 1680 PKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDK 1737
Score = 90.5 bits (223), Expect = 7e-18
Identities = 70/216 (32%), Positives = 109/216 (50%), Gaps = 11/216 (5%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+AA S G D V+ LL AD+N+ + G TAL AC +D+VK L+ AN+ +
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSE-GEVPSDLAEEPAMKDLLLEQVKKQG 181
G TPL AAS G++ +A ++HGA + ++E E LA D ++ + + G
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD-MVRFLLEAG 395
Query: 182 IDLEQSRKEEEQQMLQD--------ARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVL 233
D E E +++ AR L+SG ++ A S + L +AA G+ E+
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM-PADSFESPLTLAACGGHVELA 454
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
LLI+ G L + +G+TPL AA G +E ++L
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490
Score = 84.7 bits (208), Expect = 4e-16
Identities = 100/423 (23%), Positives = 172/423 (40%), Gaps = 56/423 (13%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE- 123
ACS G + V LLARGA+ NV T L A ++++K L+ A +N +
Sbjct: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188
Query: 124 -GWTPLHAAASCGYLNIAEYFINHGASV--------------GIVNSEGEVPSDLAEEPA 168
G +PL AA G++ + ++ G+ + EV S L + A
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248
Query: 169 MKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKG 228
+ + ++ E ++L D +N+ + R TAL +AA KG
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-----TALTIAADKG 1303
Query: 229 YSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFD 288
+ + LLI G ++V++ G TPL A++ G + +L +A D+D + TP
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363
Query: 289 VA-DEGLVEHLELLQKKQNVLRSEKETR---------------NKLIESDLNSKIQSGFF 332
A +G V+ ++ L K+ N S+ E ++ +E+ + +K Q
Sbjct: 1364 SAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAE 1423
Query: 333 KNKEK--MLYEEETPKSQE---------MEEENKESSSSSSEEEEGEDEASESETEKEAD 381
NK +L E + KS+E E+ KE EE++ + E E KE
Sbjct: 1424 ANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENS 1483
Query: 382 KKPEAFVNHSNSESKSSITEQIP-----APAQNTFSASSARRFSSGLFNKPEEPKDESPS 436
+ PE + E+ + +++P A T S+ + +F K +PS
Sbjct: 1484 ELPE---DEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPS 1540
Query: 437 SWR 439
+ R
Sbjct: 1541 TNR 1543
Score = 78.6 bits (192), Expect = 3e-14
Identities = 82/295 (27%), Positives = 131/295 (44%), Gaps = 45/295 (15%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
ACS GD + VRKLL G +N +G + L AC ++ + L+ ANV + N+G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 125 -WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGID 183
TPL AA+S GYL+I + + H A V ++ G A D +++ + +G +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD-IVKVLLNEGAN 330
Query: 184 LEQSRKE--------------EEQQMLQDARQWLNS----------------GKIEDVR- 212
+E + E ++L D +N+ G ++ VR
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 213 QARSGA----------TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGV 262
+GA TAL A G+ EV RLL+ +G ++N+ +PL AA G
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
Query: 263 KEACSILAEALCDMDIRNKLGQTP-FDVADEGLVEHLE-LLQKKQNVLRSEKETR 315
E ++L E +++ N G TP + A EG E + LL + N+ +ET+
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Score = 66.2 bits (160), Expect = 1e-10
Identities = 59/211 (27%), Positives = 97/211 (45%), Gaps = 20/211 (9%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ AC G + R LL GA +N + L A ++++ L+E AN+ + ++
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA-------MKDLLLE 175
EG+TPL AA G+ + + GA+ +N++ E + A A + D L+
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGAN---INAQTEETQETALTLACCGGFSEVADFLI- 525
Query: 176 QVKKQGIDLEQS-----RKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
K G D+E + ++ L+ + L SG A +G TAL A G++
Sbjct: 526 ---KAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA-TGDTALTYACENGHT 581
Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWG 261
+V +L+QAG +L + G TPL AA G
Sbjct: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAG 612
Score = 61.2 bits (147), Expect = 4e-09
Identities = 52/212 (24%), Positives = 99/212 (46%), Gaps = 12/212 (5%)
Query: 93 TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
TAL AC + ++V L+ A + +D +G+TPL AA+ G++ + E ++ G +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 153 VNSE-GEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDA--------RQWL 203
+ + P LA ++ +++ + +G + E + + A + L
Sbjct: 1117 QSERTKDTPLSLACSGGRQE-VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 204 NSG-KIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ-DYDGWTPLHAAAHWG 261
N+G +I ++ G + L +AA G+ ++LL+ G ++N Q + + T L A G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 262 VKEACSILAEALCDMDIRNKLGQTPFDVADEG 293
E S+L + +++ R K G TP A G
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1267
Score = 54.7 bits (130), Expect = 4e-07
Identities = 54/202 (26%), Positives = 93/202 (46%), Gaps = 28/202 (13%)
Query: 72 DEVRKLLARGADINTVNVDGLT--ALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLH 129
DE L R N+ N + +L +AC D +++ V+ L++ +VN+ EG + L
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
Query: 130 AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK 189
A S GY +A+ + A+V ++G++ +A A L+ VK
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA---ASSGGYLDIVK----------- 289
Query: 190 EEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYD 249
+L DA +NS Q+ +G TAL A A G+ +++++L+ G + + +
Sbjct: 290 ---LLLLHDAD--VNS-------QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337
Query: 250 GWTPLHAAAHWGVKEACSILAE 271
G TPL AA G E +L +
Sbjct: 338 GHTPLMEAASAGHVEVARVLLD 359
Score = 53.1 bits (126), Expect = 1e-06
Identities = 29/88 (32%), Positives = 48/88 (54%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ A G + V+ LLA GA+++ G TAL AC + + D+ L++ A++ +
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASV 150
G TPL AA G+L ++ I+ GA+V
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANV 627
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 1/85 (1%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD-NE 123
AC +G TD LL GAD+ + G T L +A +L V+FL+ ANVN+ N
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 124 GWTPLHAAASCGYLNIAEYFINHGA 148
T + A + G+L + E + HGA
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGA 659
Score = 46.2 bits (108), Expect = 1e-04
Identities = 92/413 (22%), Positives = 151/413 (36%), Gaps = 94/413 (22%)
Query: 58 DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
D A+ +AA G L+ RGA I+ N G T L A + D+V+ LV+ A+V
Sbjct: 1293 DTALTIAA-DKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Query: 118 NQQDNEGWTPLHAAASCGYLNIAEYFIN---------------------------HGASV 150
+ DN TPL +A G++ + +Y + H
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVE 1411
Query: 151 GIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIED 210
IV ++ + AE +LL++ +DLE+SR+E +Q L R+ + +
Sbjct: 1412 TIVKAKDQ---QAAEANKNASILLKE-----LDLEKSREESRKQALAAKREKRKEKRKKK 1463
Query: 211 VRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAH----------- 259
+ + K SE L E N +D + P+ +
Sbjct: 1464 KEEQKRKQEEDEENKPKENSE---LPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISAT 1520
Query: 260 -------WGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK 312
+G K A + + + +NK +TP +H+ L Q+K + +
Sbjct: 1521 SATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKING 1580
Query: 313 ETR----------NKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS-- 360
E R + L +D NS+ SG KSQE+ +SS
Sbjct: 1581 EPRGGGAGGNSDSDNLDSTDCNSESSSG--------------GKSQELNFVMDVNSSKYP 1626
Query: 361 ----SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQN 409
S+EE+ S+++T E + P NS S S T +P + N
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTRLEGEVTP-------NSLSTSYKTVSLPLSSPN 1672
Score = 31.6 bits (70), Expect = 3.8
Identities = 21/60 (35%), Positives = 29/60 (48%)
Query: 58 DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
D V AC+ G V LLA GAD DG T L +A + ++V +L++ NV
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 94.7 bits (234), Expect = 4e-19
Identities = 134/598 (22%), Positives = 237/598 (39%), Gaps = 99/598 (16%)
Query: 63 LAACSSGDTDEVRKLLARGADINT-VNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
+ A +G V+ LL G+DIN + + TAL AC ++V L++ +ANV +
Sbjct: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254
Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQG 181
G TPL AAS GY + ++ GA V + P+ +D L +G
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADV-----------NAPPVPSSRDTALTIAADKG 1303
Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGY 241
+ ++ G DVR + G T L +A+ G+ +V++LL+QAG
Sbjct: 1304 -------------HYKFCELLIHRGAHIDVRN-KKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 242 ELNVQDYDGWTPLHAAAHWG--------VKEA--------CSILAEALCDMDIRNKLGQ- 284
+++ D TPL +A G VKE C + D ++ K Q
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQC 1409
Query: 285 --TPFDVADEGLVE---HLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
T D+ E + +L K+ ++ +S +E+R + + + + + K K+K
Sbjct: 1410 VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE----KRKKK-- 1463
Query: 340 YEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN---SESK 396
+EE + QE +EENK +S E+E E+E ++ + E+E +P + + S +
Sbjct: 1464 -KEEQKRKQEEDEENKPKENSELPEDEDEEE-NDEDVEQEVPIEPPSATTTTTIGISATS 1521
Query: 397 SSITEQIPAPAQNTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVAN 456
++ T N + S R NK + K+ P++ L H L++
Sbjct: 1522 ATFTNVFGKKRANVVTTPSTNR-----KNKKNKTKETPPTA---HLILPEQHMSLAQQKA 1573
Query: 457 SREPI--RDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKE-- 512
+ I RG +S S DN D N S ++LN D+ +
Sbjct: 1574 DKNKINGEPRGGGAGGNSDS-------DNLDSTDCNSESSSGGKSQELNFVMDVNSSKYP 1626
Query: 513 -----NRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTA 567
++E + S + TR +G P +++ S Y + L + + + T+
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTR------LEGEVTPNSLSTS-YKTVSLPLSSPNIKLNLTS 1679
Query: 568 EKTADNVSSSTPLCVITNRPLPSTAN---------GVTATPVLSITGTDSSVEAREKR 616
K V ++ L A+ G T + +TG V+ ++ +
Sbjct: 1680 PKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDK 1737
Score = 90.5 bits (223), Expect = 7e-18
Identities = 70/216 (32%), Positives = 109/216 (50%), Gaps = 11/216 (5%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+AA S G D V+ LL AD+N+ + G TAL AC +D+VK L+ AN+ +
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSE-GEVPSDLAEEPAMKDLLLEQVKKQG 181
G TPL AAS G++ +A ++HGA + ++E E LA D ++ + + G
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD-MVRFLLEAG 395
Query: 182 IDLEQSRKEEEQQMLQD--------ARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVL 233
D E E +++ AR L+SG ++ A S + L +AA G+ E+
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM-PADSFESPLTLAACGGHVELA 454
Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
LLI+ G L + +G+TPL AA G +E ++L
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490
Score = 84.7 bits (208), Expect = 4e-16
Identities = 100/423 (23%), Positives = 172/423 (40%), Gaps = 56/423 (13%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE- 123
ACS G + V LLARGA+ NV T L A ++++K L+ A +N +
Sbjct: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188
Query: 124 -GWTPLHAAASCGYLNIAEYFINHGASV--------------GIVNSEGEVPSDLAEEPA 168
G +PL AA G++ + ++ G+ + EV S L + A
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248
Query: 169 MKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKG 228
+ + ++ E ++L D +N+ + R TAL +AA KG
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-----TALTIAADKG 1303
Query: 229 YSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFD 288
+ + LLI G ++V++ G TPL A++ G + +L +A D+D + TP
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363
Query: 289 VA-DEGLVEHLELLQKKQNVLRSEKETR---------------NKLIESDLNSKIQSGFF 332
A +G V+ ++ L K+ N S+ E ++ +E+ + +K Q
Sbjct: 1364 SAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAE 1423
Query: 333 KNKEK--MLYEEETPKSQE---------MEEENKESSSSSSEEEEGEDEASESETEKEAD 381
NK +L E + KS+E E+ KE EE++ + E E KE
Sbjct: 1424 ANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENS 1483
Query: 382 KKPEAFVNHSNSESKSSITEQIP-----APAQNTFSASSARRFSSGLFNKPEEPKDESPS 436
+ PE + E+ + +++P A T S+ + +F K +PS
Sbjct: 1484 ELPE---DEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPS 1540
Query: 437 SWR 439
+ R
Sbjct: 1541 TNR 1543
Score = 78.6 bits (192), Expect = 3e-14
Identities = 82/295 (27%), Positives = 131/295 (44%), Gaps = 45/295 (15%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
ACS GD + VRKLL G +N +G + L AC ++ + L+ ANV + N+G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 125 -WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGID 183
TPL AA+S GYL+I + + H A V ++ G A D +++ + +G +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD-IVKVLLNEGAN 330
Query: 184 LEQSRKE--------------EEQQMLQDARQWLNS----------------GKIEDVR- 212
+E + E ++L D +N+ G ++ VR
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 213 QARSGA----------TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGV 262
+GA TAL A G+ EV RLL+ +G ++N+ +PL AA G
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
Query: 263 KEACSILAEALCDMDIRNKLGQTP-FDVADEGLVEHLE-LLQKKQNVLRSEKETR 315
E ++L E +++ N G TP + A EG E + LL + N+ +ET+
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Score = 66.2 bits (160), Expect = 1e-10
Identities = 59/211 (27%), Positives = 97/211 (45%), Gaps = 20/211 (9%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ AC G + R LL GA +N + L A ++++ L+E AN+ + ++
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA-------MKDLLLE 175
EG+TPL AA G+ + + GA+ +N++ E + A A + D L+
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGAN---INAQTEETQETALTLACCGGFSEVADFLI- 525
Query: 176 QVKKQGIDLEQS-----RKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
K G D+E + ++ L+ + L SG A +G TAL A G++
Sbjct: 526 ---KAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA-TGDTALTYACENGHT 581
Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWG 261
+V +L+QAG +L + G TPL AA G
Sbjct: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAG 612
Score = 61.2 bits (147), Expect = 4e-09
Identities = 52/212 (24%), Positives = 99/212 (46%), Gaps = 12/212 (5%)
Query: 93 TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
TAL AC + ++V L+ A + +D +G+TPL AA+ G++ + E ++ G +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 153 VNSE-GEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDA--------RQWL 203
+ + P LA ++ +++ + +G + E + + A + L
Sbjct: 1117 QSERTKDTPLSLACSGGRQE-VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 204 NSG-KIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ-DYDGWTPLHAAAHWG 261
N+G +I ++ G + L +AA G+ ++LL+ G ++N Q + + T L A G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 262 VKEACSILAEALCDMDIRNKLGQTPFDVADEG 293
E S+L + +++ R K G TP A G
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1267
Score = 54.7 bits (130), Expect = 4e-07
Identities = 54/202 (26%), Positives = 93/202 (46%), Gaps = 28/202 (13%)
Query: 72 DEVRKLLARGADINTVNVDGLT--ALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLH 129
DE L R N+ N + +L +AC D +++ V+ L++ +VN+ EG + L
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
Query: 130 AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK 189
A S GY +A+ + A+V ++G++ +A A L+ VK
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA---ASSGGYLDIVK----------- 289
Query: 190 EEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYD 249
+L DA +NS Q+ +G TAL A A G+ +++++L+ G + + +
Sbjct: 290 ---LLLLHDAD--VNS-------QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337
Query: 250 GWTPLHAAAHWGVKEACSILAE 271
G TPL AA G E +L +
Sbjct: 338 GHTPLMEAASAGHVEVARVLLD 359
Score = 53.1 bits (126), Expect = 1e-06
Identities = 29/88 (32%), Positives = 48/88 (54%)
Query: 63 LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
+ A G + V+ LLA GA+++ G TAL AC + + D+ L++ A++ +
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599
Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASV 150
G TPL AA G+L ++ I+ GA+V
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANV 627
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 1/85 (1%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD-NE 123
AC +G TD LL GAD+ + G T L +A +L V+FL+ ANVN+ N
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 124 GWTPLHAAASCGYLNIAEYFINHGA 148
T + A + G+L + E + HGA
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGA 659
Score = 46.2 bits (108), Expect = 1e-04
Identities = 92/413 (22%), Positives = 151/413 (36%), Gaps = 94/413 (22%)
Query: 58 DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
D A+ +AA G L+ RGA I+ N G T L A + D+V+ LV+ A+V
Sbjct: 1293 DTALTIAA-DKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Query: 118 NQQDNEGWTPLHAAASCGYLNIAEYFIN---------------------------HGASV 150
+ DN TPL +A G++ + +Y + H
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVE 1411
Query: 151 GIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIED 210
IV ++ + AE +LL++ +DLE+SR+E +Q L R+ + +
Sbjct: 1412 TIVKAKDQ---QAAEANKNASILLKE-----LDLEKSREESRKQALAAKREKRKEKRKKK 1463
Query: 211 VRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAH----------- 259
+ + K SE L E N +D + P+ +
Sbjct: 1464 KEEQKRKQEEDEENKPKENSE---LPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISAT 1520
Query: 260 -------WGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK 312
+G K A + + + +NK +TP +H+ L Q+K + +
Sbjct: 1521 SATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKING 1580
Query: 313 ETR----------NKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS-- 360
E R + L +D NS+ SG KSQE+ +SS
Sbjct: 1581 EPRGGGAGGNSDSDNLDSTDCNSESSSG--------------GKSQELNFVMDVNSSKYP 1626
Query: 361 ----SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQN 409
S+EE+ S+++T E + P NS S S T +P + N
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTRLEGEVTP-------NSLSTSYKTVSLPLSSPN 1672
Score = 31.6 bits (70), Expect = 3.8
Identities = 21/60 (35%), Positives = 29/60 (48%)
Query: 58 DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
D V AC+ G V LLA GAD DG T L +A + ++V +L++ NV
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 94.4 bits (233), Expect = 5e-19
Identities = 66/224 (29%), Positives = 113/224 (50%), Gaps = 15/224 (6%)
Query: 83 DINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY 142
++N + DG +ALH A ++ N +++ L+E +A V+ +DN+G PLH AA G +
Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
Query: 143 FINHGASVGIVNSEGEVPSDLAEEPAMKDL--LLEQVKKQGIDLEQSRKEEEQQMLQDAR 200
+ G++V I + EG +P LA + D+ +L Q + ++ S K + R
Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
Query: 201 -----QWLNSGKIEDVRQAR-------SGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
L+S + + R +G + LH+AA G+ +++RLL+QAG ++N Q
Sbjct: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220
Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADE 292
G T LH AA G E +L ++ + +RN QT D+ +
Sbjct: 221 SG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQ 263
Score = 58.9 bits (141), Expect = 2e-08
Identities = 57/219 (26%), Positives = 97/219 (44%), Gaps = 24/219 (10%)
Query: 65 ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
A G + ++ +L G+ +N + +G LH A + D+ + L+++++N DN G
Sbjct: 89 AAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSG 148
Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
TPL A G + + + ++ ++ P D A +P L K ID+
Sbjct: 149 KTPLDLACEFGRVGVVQLLLSSNMCAALLEPR---PGD-ATDPNGTSPLHLAAKNGHIDI 204
Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
R L +G I+ RQ +SG TALH AA G +EV+RLL+ +G +
Sbjct: 205 --------------IRLLLQAG-IDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH 248
Query: 245 VQDYDGWTPLHAAAHWGVKEAC----SILAEALCDMDIR 279
V++ T L + +A +L EA + +R
Sbjct: 249 VRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.123 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,093,698
Number of Sequences: 37866
Number of extensions: 1888543
Number of successful extensions: 34976
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 826
Number of HSP's successfully gapped in prelim test: 1188
Number of HSP's that attempted gapping in prelim test: 14441
Number of HSP's gapped (non-prelim): 13138
length of query: 982
length of database: 18,247,518
effective HSP length: 112
effective length of query: 870
effective length of database: 14,006,526
effective search space: 12185677620
effective search space used: 12185677620
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.