Search of human proteins with 4504821

Search of human proteins with 4504821

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504821 potassium voltage-gated channel, shaker-related
subfamily, member 6 [Homo sapiens]
         (529 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504821 potassium voltage-gated channel, shaker-related subfa...  1070   0.0  
gi|88758565 potassium voltage-gated channel, shaker-related subf...   634   0.0  
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   623   e-178
gi|25952087 potassium voltage-gated channel, shaker-related subf...   612   e-175
gi|119395748 potassium voltage-gated channel subfamily A member ...   605   e-173
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   602   e-172
gi|25952092 potassium voltage-gated channel, shaker-related subf...   566   e-161
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   544   e-155
gi|24497460 Shaw-related voltage-gated potassium channel protein...   270   3e-72
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   259   4e-69
gi|163792201 Shaw-related voltage-gated potassium channel protei...   259   4e-69
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   256   5e-68
gi|88758576 Shaw-related voltage-gated potassium channel protein...   254   1e-67
gi|24497462 Shaw-related voltage-gated potassium channel protein...   254   1e-67
gi|24497464 Shaw-related voltage-gated potassium channel protein...   254   1e-67
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   253   2e-67
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   252   5e-67
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   247   2e-65
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   245   6e-65
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   245   6e-65
gi|21217561 Shaw-related voltage-gated potassium channel protein...   242   7e-64
gi|21217563 Shaw-related voltage-gated potassium channel protein...   242   7e-64
gi|24497458 Shaw-related voltage-gated potassium channel protein...   242   7e-64
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   223   4e-58
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   219   5e-57
gi|20070166 potassium voltage-gated channel, subfamily F, member...   211   2e-54
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   203   3e-52
gi|27436988 potassium voltage-gated channel, subfamily G, member...   202   6e-52
gi|19071574 potassium voltage-gated channel, subfamily G, member...   199   5e-51
gi|27436993 potassium voltage-gated channel, subfamily G, member...   190   2e-48

>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 529/529 (100%), Positives = 529/529 (100%)

Query: 1   MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS 60
           MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS
Sbjct: 1   MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS 60

Query: 61  LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE 120
           LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE
Sbjct: 61  LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE 120

Query: 121 IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS 180
           IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS
Sbjct: 121 IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS 180

Query: 181 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP 240
           VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP
Sbjct: 181 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP 240

Query: 241 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 300
           GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID
Sbjct: 241 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 300

Query: 301 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 360
           LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK
Sbjct: 301 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 360

Query: 361 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM 420
           GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM
Sbjct: 361 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM 420

Query: 421 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV 480
           TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV
Sbjct: 421 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV 480

Query: 481 TCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV 529
           TCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV
Sbjct: 481 TCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV 529


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  634 bits (1635), Expect = 0.0
 Identities = 340/481 (70%), Positives = 369/481 (76%), Gaps = 60/481 (12%)

Query: 19  EGEQQDAGDFPEAGG--GGGC-----------------CSSERLVINISGLRFETQLRTL 59
           E E  D G  P  GG  GGGC                 C  ER+VINISGLRFETQL+TL
Sbjct: 63  EPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTL 122

Query: 60  SLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLE 119
             FP+TLLGDP RR+R+FDPLRNEYFFDRNRPSFDAILYYYQSGGR+RRPVNVP+DIF E
Sbjct: 123 CQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSE 182

Query: 120 EIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIV 179
           EIRFYQLG+EA+  FREDEG L    E+E+PLP + FQRQVWLLFEYPESSGPARGIAIV
Sbjct: 183 EIRFYQLGEEAMEKFREDEGFL---REEERPLPRRDFQRQVWLLFEYPESSGPARGIAIV 239

Query: 180 SVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGIT 239
           SVLVILISIVIFCLETLP+FR +          +  P S      E              
Sbjct: 240 SVLVILISIVIFCLETLPEFRDE----------KDYPASTSQDSFE-------------- 275

Query: 240 PGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNII 299
                 G S+S S  G S F+DPFF+VETLCI+WF+FELLVRF ACPSK  F RNIMN+I
Sbjct: 276 ----AAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLI 331

Query: 300 DLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHS 359
           D+VAI PYFITLGTEL ++Q           NGQQAMSLAILRVIRLVRVFRIFKLSRHS
Sbjct: 332 DIVAIIPYFITLGTELAERQ----------GNGQQAMSLAILRVIRLVRVFRIFKLSRHS 381

Query: 360 KGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVT 419
           KGLQILG+TL+ASMRELGLLIFFLFIGVILFSSAVYFAEADD  S F SIPDAFWWAVVT
Sbjct: 382 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVT 441

Query: 420 MTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTH 479
           MTTVGYGDM+P+T+GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE EEQ QY H
Sbjct: 442 MTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMH 501

Query: 480 V 480
           V
Sbjct: 502 V 502


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  623 bits (1606), Expect = e-178
 Identities = 347/528 (65%), Positives = 390/528 (73%), Gaps = 63/528 (11%)

Query: 20  GEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDP 79
           G  QD  D PEA     CC  ER+VINISGLRFETQL+TL+ FP+TLLGDP +R+R+FDP
Sbjct: 17  GHPQDTYD-PEADHE--CC--ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDP 71

Query: 80  LRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEG 139
           LRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIF EEIRFY+LG+EA+  FREDEG
Sbjct: 72  LRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEG 131

Query: 140 CLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQF 199
            + E   +E+PLP   FQRQVWLLFEYPESSGPAR IAIVSV+VILISIV FCLETLP F
Sbjct: 132 YIKE---EERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIF 188

Query: 200 RVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFF 259
           R                      E E+      TFH         T  +S++     + F
Sbjct: 189 R---------------------DENEDMHGSGVTFH---------TYSNSTIGYQQSTSF 218

Query: 260 TDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQ 319
           TDPFF+VETLCI+WF+FE LVRF ACPSK  FF NIMNIID+VAI PYFITLGTEL ++ 
Sbjct: 219 TDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKP 278

Query: 320 EQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLL 379
           E         Q GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG+TL+ASMRELGLL
Sbjct: 279 ED-------AQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLL 331

Query: 380 IFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVG 439
           IFFLFIGVILFSSAVYFAEAD+ +S FPSIPDAFWWAVV+MTTVGYGDM P T+GGKIVG
Sbjct: 332 IFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVG 391

Query: 440 SLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVT-CGQ--PAPDLRATDNG- 495
           SLCAIAGVLTIALPVPVIVSNFNYFYHRETE EEQ QY  VT C +   +PDL+ + +  
Sbjct: 392 SLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSAS 451

Query: 496 -LGKPDFPE-------ANRERRPSYLPTPHRAYAE------KRMLTEV 529
            + K D+ E       +N + R   L T +   A        +MLT+V
Sbjct: 452 TISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 499


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  612 bits (1579), Expect = e-175
 Identities = 324/460 (70%), Positives = 357/460 (77%), Gaps = 25/460 (5%)

Query: 18  PEGEQQDA----GDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRR 73
           PE E+++     G   +   G      +R+ INISGLRFETQL TL+ FP+TLLGDP +R
Sbjct: 93  PEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKR 152

Query: 74  VRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAA 133
           +R+FDPLRNEYFFDRNRPSFD ILYYYQSGGRLRRPVNV LD+F +EIRFYQLGDEA+  
Sbjct: 153 LRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMER 212

Query: 134 FREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCL 193
           FREDEG + E   +EKPLP   FQRQVWL+FEYPESSG AR IAIVSVLVILISI+ FCL
Sbjct: 213 FREDEGFIKE---EEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCL 269

Query: 194 ETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLST 253
           ETLP+FR +        + R  P            + S         G M      +++ 
Sbjct: 270 ETLPEFRDERE------LLRHPPAPHQPPAPAPGANGS---------GVMAPPSGPTVAP 314

Query: 254 LGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGT 313
           L      DPFF+VET C++WFTFELLVRF ACPSK  F RNIMNIID+VAIFPYFITLGT
Sbjct: 315 LLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGT 374

Query: 314 ELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM 373
           EL    EQQP  GGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM
Sbjct: 375 ELA---EQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM 431

Query: 374 RELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTV 433
           RELGLLIFFLFIGVILFSSAVYFAEAD+  + F SIPDAFWWAVVTMTTVGYGDM P+TV
Sbjct: 432 RELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITV 491

Query: 434 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEE 473
           GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET+ EE
Sbjct: 492 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEE 531


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  605 bits (1561), Expect = e-173
 Identities = 323/503 (64%), Positives = 376/503 (74%), Gaps = 54/503 (10%)

Query: 14  EVRGPEGEQQDAGDFPEAGGGGG--CCSSERLVINISGLRFETQLRTLSLFPDTLLGDPG 71
           E     G  QD G +P         CC  ER+VINISGLRFETQL+TL+ FP+TLLG+P 
Sbjct: 11  EASAAPGHPQD-GSYPRQADHDDHECC--ERVVINISGLRFETQLKTLAQFPNTLLGNPK 67

Query: 72  RRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEAL 131
           +R+R+FDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLD+F EEI+FY+LG+EA+
Sbjct: 68  KRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAM 127

Query: 132 AAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIF 191
             FREDEG + E   +E+PLP + +QRQVWLLFEYPESSGPAR IAIVSV+VILISIVIF
Sbjct: 128 EKFREDEGFIKE---EERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIF 184

Query: 192 CLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSL 251
           CLETLP+ +                         +D+D + T H             ++ 
Sbjct: 185 CLETLPELK-------------------------DDKDFTGTVHRI----------DNTT 209

Query: 252 STLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITL 311
                + FTDPFF+VETLCI+WF+FEL+VRF ACPSK  FF+NIMN ID+VAI PYFITL
Sbjct: 210 VIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITL 269

Query: 312 GTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQA 371
           GTE+ +Q+        G Q G+QA SLAILRVIRLVRVFRIFKLSRHSKGLQILG+TL+A
Sbjct: 270 GTEIAEQE--------GNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 321

Query: 372 SMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPM 431
           SMRELGLLIFFLFIGVILFSSAVYFAEA++ +S F SIPDAFWWAVV+MTTVGYGDMYP+
Sbjct: 322 SMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPV 381

Query: 432 TVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPD--- 488
           T+GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE EEQ Q  HV+    A D   
Sbjct: 382 TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDL 441

Query: 489 LRATDNGLGKPDFPEANRERRPS 511
            R + + + K ++ E   +   S
Sbjct: 442 SRRSSSTMSKSEYMEIEEDMNNS 464


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  602 bits (1551), Expect = e-172
 Identities = 319/464 (68%), Positives = 360/464 (77%), Gaps = 45/464 (9%)

Query: 29  PEAGGGGG--------CCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPL 80
           P+  GGGG        CC  ER+VIN+SGLRFETQ++TL+ FP+TLLGDP +R ++FDPL
Sbjct: 158 PQDEGGGGYSSVRYSDCC--ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPL 215

Query: 81  RNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGC 140
           RNEYFFDRNRPSFDAILYYYQSGGRL+RPVNVP DIF EE++FYQLG+EAL  FREDEG 
Sbjct: 216 RNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGF 275

Query: 141 LPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFR 200
           + E  E+++ LP   F++Q+WLLFEYPESS PARGIAIVSVLVILISIVIFCLETLP+FR
Sbjct: 276 VRE--EEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFR 333

Query: 201 VDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFT 260
            D           V  +S G               HG   G +    +  L   G + F 
Sbjct: 334 DDR--------DLVMALSAGG--------------HG---GLLNDTSAPHLENSGHTIFN 368

Query: 261 DPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQE 320
           DPFF+VET+CIVWF+FE +VR  ACPS+  FF+NIMNIID+V+I PYFITLGT+L QQQ 
Sbjct: 369 DPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQ- 427

Query: 321 QQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLI 380
                GGG    QQAMS AILR+IRLVRVFRIFKLSRHSKGLQILG TL+ASMRELGLLI
Sbjct: 428 -----GGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLI 482

Query: 381 FFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGS 440
           FFLFIGVILFSSAVYFAEAD+  + F SIPDAFWWAVVTMTTVGYGDM P+TVGGKIVGS
Sbjct: 483 FFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGS 542

Query: 441 LCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTH--VTC 482
           LCAIAGVLTIALPVPVIVSNFNYFYHRETE EEQ Q T   V+C
Sbjct: 543 LCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSC 586


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  567 bits (1460), Expect = e-161
 Identities = 308/495 (62%), Positives = 351/495 (70%), Gaps = 49/495 (9%)

Query: 36  GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA 95
           GCC  ERLV+N++GLRFET+ RTL  FPDTLLGDP RR RF+D  R EYFFDR+RPSFDA
Sbjct: 10  GCC--ERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDA 67

Query: 96  ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGC-LPEGGEDEKPLPSQ 154
           +LYYYQSGGRLRRP +VPLD+FLEE+ FY LG  ALA  REDEGC +P     E+PLP +
Sbjct: 68  VLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPP----ERPLPRR 123

Query: 155 PFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRV 214
            F RQ+WLLFE+PESS  AR +A+VSVLVIL+SIV+FCLETLP FR D  G      +  
Sbjct: 124 AFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAA 183

Query: 215 SPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWF 274
            P                 F   +       G    L       F DPFF+VETLCI WF
Sbjct: 184 GP-----------------FPAPLNGSSQMPGNPPRLP------FNDPFFVVETLCICWF 220

Query: 275 TFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQ 334
           +FELLVR   CPSK  FF+N+MN+ID VAI PYF+ LGTEL +Q+            GQQ
Sbjct: 221 SFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGV----------GQQ 270

Query: 335 AMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAV 394
           AMSLAILRVIRLVRVFRIFKLSRHSKGLQILG+TL+ASMRELGLLIFFLFIGV+LFSSAV
Sbjct: 271 AMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAV 330

Query: 395 YFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPV 454
           YFAE D  DS F SIP++FWWAVVTMTTVGYGDM P+TVGGKIVGSLCAIAGVLTI+LPV
Sbjct: 331 YFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPV 390

Query: 455 PVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLP 514
           PVIVSNF+YFYHRETE EE G ++HV      P     + GL   + PE         LP
Sbjct: 391 PVIVSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPE---------LP 441

Query: 515 TPHRAYAEKRMLTEV 529
            P  A   K ++TEV
Sbjct: 442 PPLWAPPGKHLVTEV 456


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  544 bits (1402), Expect = e-155
 Identities = 284/435 (65%), Positives = 329/435 (75%), Gaps = 46/435 (10%)

Query: 40  SERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYY 99
           ++R++INI+GLRFETQLRTLS FP+TLLGD  +R++FFD +RNEYFFDRNRPSFD ILYY
Sbjct: 85  NQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYY 144

Query: 100 YQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQ 159
           YQSGG++RRP NVP+DIF +EI FY+LG EA+  FREDEG + +    E  LP+    RQ
Sbjct: 145 YQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKD---PETLLPTNDIHRQ 201

Query: 160 VWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSR 219
            WLLFEYPESS  AR +A+VSVLV++ISI IFCLETLP+FR D                 
Sbjct: 202 FWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFRED----------------- 244

Query: 220 GSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELL 279
             +E +   D +                  S + L  + FTDPFF+VE+ CIVWFTFEL+
Sbjct: 245 --RELKVVRDPNLNM---------------SKTVLSQTMFTDPFFMVESTCIVWFTFELV 287

Query: 280 VRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLA 339
           +RF  CPSK  FFRNIMNIID+++I PYF TL TELVQ+ E          + QQ MSLA
Sbjct: 288 LRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEP---------SAQQNMSLA 338

Query: 340 ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEA 399
           ILR+IRLVRVFRIFKLSRHSKGLQILG+TL+ASMRELGLLIFFLFIGVILFSSAVYFAE 
Sbjct: 339 ILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEV 398

Query: 400 DDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVS 459
           D+ +S F SIPD FWWAVVTMTTVGYGDM P T GGKIVG+LCAIAGVLTIALPVPVIVS
Sbjct: 399 DEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVS 458

Query: 460 NFNYFYHRETEQEEQ 474
           NFNYFYHRETE EE+
Sbjct: 459 NFNYFYHRETENEEK 473


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  270 bits (689), Expect = 3e-72
 Identities = 197/534 (36%), Positives = 265/534 (49%), Gaps = 128/534 (23%)

Query: 12  PGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLG--- 68
           PG+ R        A      GGGGG   S ++VIN+ G+R ET   TL   P T L    
Sbjct: 61  PGDRRAEPCPGLPAAAMGRHGGGGG--DSGKIVINVGGVRHETYRSTLRTLPGTRLAGLT 118

Query: 69  DPGRRVRF-FDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL- 126
           +P    RF +DP  +E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ + 
Sbjct: 119 EPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELGFWGID 177

Query: 127 -----------------GDEALAAFR---------------------EDE-----GCLPE 143
                             +EAL +F                      +DE     G L  
Sbjct: 178 ETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDG 237

Query: 144 GGEDEKPLPSQP----------------------FQRQVWLLFEYPESSGPARGIAIVSV 181
            G + K L  Q                       +Q +VW LFE P SS  AR +A  S+
Sbjct: 238 AGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASL 297

Query: 182 LVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPG 241
             ILISI  FCLET   F       +N  V++ SP+     E              IT  
Sbjct: 298 FFILISITTFCLETHEGF----IHISNKTVTQASPIPGAPPE-------------NITNV 340

Query: 242 EMGTGGSSSLSTLGGSFFTDPFF-LVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 300
           E+                T+PF   VE +C+VWFTFE L+R + CP K  F ++ +NIID
Sbjct: 341 EVE---------------TEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIID 385

Query: 301 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 360
            VAI P+++ +G   +  +  +               L  LRV+R VR+ RIFKL+RH  
Sbjct: 386 CVAILPFYLEVGLSGLSSKAAKDV-------------LGFLRVVRFVRILRIFKLTRHFV 432

Query: 361 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE---ADDDDSL------FPSIPD 411
           GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE   AD DD L      F +IP 
Sbjct: 433 GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPI 492

Query: 412 AFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 465
            FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 493 GFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  259 bits (662), Expect = 4e-69
 Identities = 175/487 (35%), Positives = 249/487 (51%), Gaps = 111/487 (22%)

Query: 40  SERLVINISGLRFETQLRTLSLFPDTLLG---DPGRRVRF-FDPLRNEYFFDRNRPSFDA 95
           SER+VIN+ G R +T   TL   P T L    +P     F +DP  +E+FFDR+   F  
Sbjct: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAH 66

Query: 96  ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL------------------GDEALAAF--- 134
           IL YY++G +L  P +V   ++ EE+ F+ +                   +EAL +F   
Sbjct: 67  ILNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGA 125

Query: 135 --------REDEGCLPEG-GEDEKPLPSQ----------------PFQRQVWLLFEYPES 169
                    + +G    G GEDE  +  +                 +Q ++W LFE P S
Sbjct: 126 PLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYS 185

Query: 170 SGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSR--VSPVSRGSQEEEED 227
           S  AR +A  S+  IL+SI  FCLET  +F        N  V++  +  V  G+Q     
Sbjct: 186 SRYARYVAFASLFFILVSITTFCLETHERF--------NPIVNKTEIENVRNGTQVRYYR 237

Query: 228 EDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPS 287
           E ++  F                               +E +C+VWFTFE L+R   CP+
Sbjct: 238 EAETEAF----------------------------LTYIEGVCVVWFTFEFLMRVIFCPN 269

Query: 288 KPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLV 347
           K  F +N +NIID VAI P+++ +G   +  +  +   G              LRV+R V
Sbjct: 270 KVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG-------------FLRVVRFV 316

Query: 348 RVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE--------- 398
           R+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE         
Sbjct: 317 RILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDP 376

Query: 399 ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIV 458
           +  + + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA+PVPVIV
Sbjct: 377 SASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIV 436

Query: 459 SNFNYFY 465
           +NF  +Y
Sbjct: 437 NNFGMYY 443


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  259 bits (662), Expect = 4e-69
 Identities = 175/487 (35%), Positives = 249/487 (51%), Gaps = 111/487 (22%)

Query: 40  SERLVINISGLRFETQLRTLSLFPDTLLG---DPGRRVRF-FDPLRNEYFFDRNRPSFDA 95
           SER+VIN+ G R +T   TL   P T L    +P     F +DP  +E+FFDR+   F  
Sbjct: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAH 66

Query: 96  ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL------------------GDEALAAF--- 134
           IL YY++G +L  P +V   ++ EE+ F+ +                   +EAL +F   
Sbjct: 67  ILNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGA 125

Query: 135 --------REDEGCLPEG-GEDEKPLPSQ----------------PFQRQVWLLFEYPES 169
                    + +G    G GEDE  +  +                 +Q ++W LFE P S
Sbjct: 126 PLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYS 185

Query: 170 SGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSR--VSPVSRGSQEEEED 227
           S  AR +A  S+  IL+SI  FCLET  +F        N  V++  +  V  G+Q     
Sbjct: 186 SRYARYVAFASLFFILVSITTFCLETHERF--------NPIVNKTEIENVRNGTQVRYYR 237

Query: 228 EDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPS 287
           E ++  F                               +E +C+VWFTFE L+R   CP+
Sbjct: 238 EAETEAF----------------------------LTYIEGVCVVWFTFEFLMRVIFCPN 269

Query: 288 KPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLV 347
           K  F +N +NIID VAI P+++ +G   +  +  +   G              LRV+R V
Sbjct: 270 KVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG-------------FLRVVRFV 316

Query: 348 RVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE--------- 398
           R+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE         
Sbjct: 317 RILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDP 376

Query: 399 ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIV 458
           +  + + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA+PVPVIV
Sbjct: 377 SASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIV 436

Query: 459 SNFNYFY 465
           +NF  +Y
Sbjct: 437 NNFGMYY 443


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  256 bits (653), Expect = 5e-68
 Identities = 171/462 (37%), Positives = 236/462 (51%), Gaps = 81/462 (17%)

Query: 29  PEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDR 88
           P A G       E LV+N+SG RFET   TL  +PDTLLG   +   F+D    EYFFDR
Sbjct: 28  PPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDR 86

Query: 89  NRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL-----GDEALAAFR-------- 135
           +   F  +L +Y++G RL  P    +  F EE+ FY L     GD  L  +R        
Sbjct: 87  DPDMFRHVLNFYRTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAE 145

Query: 136 ---EDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFC 192
              EDE     G     P  S   QR +W  FE P +S  A     V+   I +S++   
Sbjct: 146 RLAEDEEAEQAGDGPALPAGSSLRQR-LWRAFENPHTSTAALVFYYVTGFFIAVSVIANV 204

Query: 193 LETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLS 252
           +ET+P                     RGS      E                        
Sbjct: 205 VETIP--------------------CRGSARRSSREQPC--------------------- 223

Query: 253 TLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLG 312
              G  F   FF ++T C++ FT E L+R  A PS+  F R++M++ID+VAI PY+I L 
Sbjct: 224 ---GERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGL- 279

Query: 313 TELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQAS 372
             LV + +    SG                 +R+ RVFRIFK SRHS+GL+ILG TL++ 
Sbjct: 280 --LVPKNDD--VSGA-------------FVTLRVFRVFRIFKFSRHSQGLRILGYTLKSC 322

Query: 373 MRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMT 432
             ELG L+F L + +I+F++ +++AE   + + F SIP AFW+ +VTMTT+GYGDM P T
Sbjct: 323 ASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPST 382

Query: 433 VGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQ 474
           + GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 383 IAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 424


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  254 bits (649), Expect = 1e-67
 Identities = 173/494 (35%), Positives = 245/494 (49%), Gaps = 115/494 (23%)

Query: 39  SSERLVINISGLRFETQLRTLSLFPDTLLG---DP---GRRVRFFDPLRN---------E 83
           +SE+++IN+ G R ET   TL   P T L    DP   GR       + +         E
Sbjct: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCE 93

Query: 84  YFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL----------------- 126
           +FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                 
Sbjct: 94  FFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152

Query: 127 -GDEALAAFREDEGC------LPEGGEDEKPLPSQP-------------------FQRQV 160
             +EAL  F   +G         E G+DE+ L  Q                    +Q ++
Sbjct: 153 DAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRM 212

Query: 161 WLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRG 220
           W LFE P SS  AR +A  S+  IL+SI  FCLET   F +D    N   + RV  ++  
Sbjct: 213 WALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDR---NVTEILRVGNITSV 269

Query: 221 SQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLV 280
               E + +   T+                               +E +C++WFT E LV
Sbjct: 270 HFRREVETEPILTY-------------------------------IEGVCVLWFTLEFLV 298

Query: 281 RFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAI 340
           R   CP    F +N++NIID VAI P+++ +G   +  +  +   G              
Sbjct: 299 RIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLG-------------F 345

Query: 341 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEA- 399
           LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE  
Sbjct: 346 LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERI 405

Query: 400 --------DDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIA 451
                    +D + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA
Sbjct: 406 GARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIA 465

Query: 452 LPVPVIVSNFNYFY 465
           +PVPVIV+NF  +Y
Sbjct: 466 MPVPVIVNNFGMYY 479


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  254 bits (649), Expect = 1e-67
 Identities = 173/494 (35%), Positives = 245/494 (49%), Gaps = 115/494 (23%)

Query: 39  SSERLVINISGLRFETQLRTLSLFPDTLLG---DP---GRRVRFFDPLRN---------E 83
           +SE+++IN+ G R ET   TL   P T L    DP   GR       + +         E
Sbjct: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCE 93

Query: 84  YFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL----------------- 126
           +FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                 
Sbjct: 94  FFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152

Query: 127 -GDEALAAFREDEGC------LPEGGEDEKPLPSQP-------------------FQRQV 160
             +EAL  F   +G         E G+DE+ L  Q                    +Q ++
Sbjct: 153 DAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRM 212

Query: 161 WLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRG 220
           W LFE P SS  AR +A  S+  IL+SI  FCLET   F +D    N   + RV  ++  
Sbjct: 213 WALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDR---NVTEILRVGNITSV 269

Query: 221 SQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLV 280
               E + +   T+                               +E +C++WFT E LV
Sbjct: 270 HFRREVETEPILTY-------------------------------IEGVCVLWFTLEFLV 298

Query: 281 RFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAI 340
           R   CP    F +N++NIID VAI P+++ +G   +  +  +   G              
Sbjct: 299 RIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLG-------------F 345

Query: 341 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEA- 399
           LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE  
Sbjct: 346 LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERI 405

Query: 400 --------DDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIA 451
                    +D + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA
Sbjct: 406 GARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIA 465

Query: 452 LPVPVIVSNFNYFY 465
           +PVPVIV+NF  +Y
Sbjct: 466 MPVPVIVNNFGMYY 479


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  254 bits (649), Expect = 1e-67
 Identities = 173/494 (35%), Positives = 245/494 (49%), Gaps = 115/494 (23%)

Query: 39  SSERLVINISGLRFETQLRTLSLFPDTLLG---DP---GRRVRFFDPLRN---------E 83
           +SE+++IN+ G R ET   TL   P T L    DP   GR       + +         E
Sbjct: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCE 93

Query: 84  YFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL----------------- 126
           +FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                 
Sbjct: 94  FFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152

Query: 127 -GDEALAAFREDEGC------LPEGGEDEKPLPSQP-------------------FQRQV 160
             +EAL  F   +G         E G+DE+ L  Q                    +Q ++
Sbjct: 153 DAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRM 212

Query: 161 WLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRG 220
           W LFE P SS  AR +A  S+  IL+SI  FCLET   F +D    N   + RV  ++  
Sbjct: 213 WALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDR---NVTEILRVGNITSV 269

Query: 221 SQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLV 280
               E + +   T+                               +E +C++WFT E LV
Sbjct: 270 HFRREVETEPILTY-------------------------------IEGVCVLWFTLEFLV 298

Query: 281 RFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAI 340
           R   CP    F +N++NIID VAI P+++ +G   +  +  +   G              
Sbjct: 299 RIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLG-------------F 345

Query: 341 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEA- 399
           LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE  
Sbjct: 346 LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERI 405

Query: 400 --------DDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIA 451
                    +D + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA
Sbjct: 406 GARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIA 465

Query: 452 LPVPVIVSNFNYFY 465
           +PVPVIV+NF  +Y
Sbjct: 466 MPVPVIVNNFGMYY 479


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  253 bits (647), Expect = 2e-67
 Identities = 166/461 (36%), Positives = 236/461 (51%), Gaps = 89/461 (19%)

Query: 40  SERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLR----------NEYFFDRN 89
           S R+ +N+ GL  E   RTL   P T LG   R     D L           NEYFFDR+
Sbjct: 30  SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL-RDCNTHDSLLEVCDDYSLDDNEYFFDRH 88

Query: 90  RPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAF--------------- 134
             +F +IL +Y++G RL     +    F +E+ ++ + +  L +                
Sbjct: 89  PGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEE 147

Query: 135 --REDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFC 192
             RE E      GE+         ++++W L E P SS  A+ +AI+S++ I++S +   
Sbjct: 148 LKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALS 207

Query: 193 LETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLS 252
           L TLP+ +                                                 SL 
Sbjct: 208 LNTLPELQ-------------------------------------------------SLD 218

Query: 253 TLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLG 312
             G S        VE +CI WFT E L+RF + P K  FF+  +N IDL+AI PY++T+ 
Sbjct: 219 EFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIF 278

Query: 313 TELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQAS 372
                +   Q       QN ++     ++++ R++R+ RI KL+RHS GLQ LG TL+ S
Sbjct: 279 LTESNKSVLQ------FQNVRR-----VVQIFRIMRILRILKLARHSTGLQSLGFTLRRS 327

Query: 373 MRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMT 432
             ELGLLI FL +G+++FSS V+FAE D+DD+ F SIP +FWWA +TMTTVGYGD+YP T
Sbjct: 328 YNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKT 387

Query: 433 VGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEE 473
           + GKIVG LC IAGVL IALP+P+IV+NF+ FY  +  QE+
Sbjct: 388 LLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 428


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  252 bits (644), Expect = 5e-67
 Identities = 167/460 (36%), Positives = 240/460 (52%), Gaps = 87/460 (18%)

Query: 40  SERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPL----------RNEYFFDRN 89
           S R+ IN+ GL  E   RTL   P T LG   R     + L           NEYFFDR+
Sbjct: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKL-RDCNTHESLLEVCDDYNLNENEYFFDRH 92

Query: 90  RPSFDAILYYYQSGGRLRRPVNVPL------------DIFLE---EIRFYQLGDEALAAF 134
             +F +IL +Y++G          L            +I+LE   + R++Q  ++     
Sbjct: 93  PGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEEL 152

Query: 135 REDEGCLPEGGEDEKPLPSQPFQRQ-VWLLFEYPESSGPARGIAIVSVLVILISIVIFCL 193
           R +   + E   +E      P +R+ +W L E P SS  A+ +AIVS+L I++S +   L
Sbjct: 153 RREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSL 212

Query: 194 ETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLST 253
            TLP+ +                      +E    +D+    H                 
Sbjct: 213 NTLPELQ--------------------ETDEFGQLNDNRQLAH----------------- 235

Query: 254 LGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGT 313
                       VE +CI WFT E L+RF + P+K  FF+  +N+IDL+AI PY++T+  
Sbjct: 236 ------------VEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFL 283

Query: 314 ELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM 373
               +   Q       QN ++     ++++ R++R+ RI KL+RHS GLQ LG TL+ S 
Sbjct: 284 TESNKSVLQ------FQNVRR-----VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSY 332

Query: 374 RELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTV 433
            ELGLLI FL +G+++FSS V+FAE D+D + F SIP +FWWA +TMTTVGYGD+YP T+
Sbjct: 333 NELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTL 392

Query: 434 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEE 473
            GKIVG LC IAGVL IALP+P+IV+NF+ FY  +  QE+
Sbjct: 393 LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 432


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  247 bits (631), Expect = 2e-65
 Identities = 157/445 (35%), Positives = 234/445 (52%), Gaps = 78/445 (17%)

Query: 43  LVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQS 102
           +V+N+SG RF+T   TL  +PDTLLG   R   F+ P   +YFFDR+   F  IL +Y++
Sbjct: 43  IVLNVSGTRFQTWQDTLERYPDTLLGSSERDF-FYHPETQQYFFDRDPDIFRHILNFYRT 101

Query: 103 GGRLRRPVNVPLDIFLEEIRFYQLGDEALA--AFREDEGCLPEGGE-----------DEK 149
           G +L  P +  +  + EE+ F+ L  E +    + E +    E  E            E 
Sbjct: 102 G-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160

Query: 150 PLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNG 209
            LP+   +++VW  FE P +S  A     V+   I +S++   +ET+P        G++ 
Sbjct: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPC-------GSSP 213

Query: 210 GVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETL 269
           G  +  P                                       G  +   FF ++T 
Sbjct: 214 GHIKELPC--------------------------------------GERYAVAFFCLDTA 235

Query: 270 CIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGG 329
           C++ FT E L+R +A PS+  F R++M+IID+VAI PY+I L        + +  SG   
Sbjct: 236 CVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGL-----VMTDNEDVSGA-- 288

Query: 330 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVIL 389
                         +R+ RVFRIFK SRHS+GL+ILG TL++   ELG L+F L + +I+
Sbjct: 289 -----------FVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIII 337

Query: 390 FSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLT 449
           F++ +++AE     S F SIP AFW+ +VTMTT+GYGDM P T+ GKI GS+C+++GVL 
Sbjct: 338 FATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLV 397

Query: 450 IALPVPVIVSNFNYFYHRETEQEEQ 474
           IALPVPVIVSNF+  YH+    +++
Sbjct: 398 IALPVPVIVSNFSRIYHQNQRADKR 422


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  245 bits (626), Expect = 6e-65
 Identities = 156/446 (34%), Positives = 234/446 (52%), Gaps = 78/446 (17%)

Query: 41  ERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYY 100
           E +V+N+SG RF+T   TL  +PDTLLG   +   FF+    EYFFDR+   F  +L +Y
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFY 98

Query: 101 QSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAF---------REDEGCLPEGGEDE--- 148
           ++G +L  P    +  + +E+ FY +  E +            RE+   L +  + E   
Sbjct: 99  RTG-KLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQ 157

Query: 149 KPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNN 208
           + +PS  F++ +W  FE P +S  A     V+   I +S++   +ET+P   V G     
Sbjct: 158 ESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPG----- 212

Query: 209 GGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVET 268
              S+  P                                       G  ++  FF ++T
Sbjct: 213 ---SKELPC--------------------------------------GERYSVAFFCLDT 231

Query: 269 LCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGG 328
            C++ FT E L+R  A PS+  F R++M+IID+VAI PY+I L          +  SG  
Sbjct: 232 ACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGL-----VMTNNEDVSGA- 285

Query: 329 GQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVI 388
                          +R+ RVFRIFK SRHS+GL+ILG TL++   ELG L+F L + +I
Sbjct: 286 ------------FVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAII 333

Query: 389 LFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVL 448
           +F++ +++AE     S F SIP +FW+ +VTMTT+GYGDM P T+ GKI GS+C+++GVL
Sbjct: 334 IFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVL 393

Query: 449 TIALPVPVIVSNFNYFYHRETEQEEQ 474
            IALPVPVIVSNF+  YH+    +++
Sbjct: 394 VIALPVPVIVSNFSRIYHQNQRADKR 419


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  245 bits (626), Expect = 6e-65
 Identities = 156/446 (34%), Positives = 234/446 (52%), Gaps = 78/446 (17%)

Query: 41  ERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYY 100
           E +V+N+SG RF+T   TL  +PDTLLG   +   FF+    EYFFDR+   F  +L +Y
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFY 98

Query: 101 QSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAF---------REDEGCLPEGGEDE--- 148
           ++G +L  P    +  + +E+ FY +  E +            RE+   L +  + E   
Sbjct: 99  RTG-KLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQ 157

Query: 149 KPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNN 208
           + +PS  F++ +W  FE P +S  A     V+   I +S++   +ET+P   V G     
Sbjct: 158 ESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPG----- 212

Query: 209 GGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVET 268
              S+  P                                       G  ++  FF ++T
Sbjct: 213 ---SKELPC--------------------------------------GERYSVAFFCLDT 231

Query: 269 LCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGG 328
            C++ FT E L+R  A PS+  F R++M+IID+VAI PY+I L          +  SG  
Sbjct: 232 ACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGL-----VMTNNEDVSGA- 285

Query: 329 GQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVI 388
                          +R+ RVFRIFK SRHS+GL+ILG TL++   ELG L+F L + +I
Sbjct: 286 ------------FVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAII 333

Query: 389 LFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVL 448
           +F++ +++AE     S F SIP +FW+ +VTMTT+GYGDM P T+ GKI GS+C+++GVL
Sbjct: 334 IFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVL 393

Query: 449 TIALPVPVIVSNFNYFYHRETEQEEQ 474
            IALPVPVIVSNF+  YH+    +++
Sbjct: 394 VIALPVPVIVSNFSRIYHQNQRADKR 419


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  242 bits (617), Expect = 7e-64
 Identities = 161/435 (37%), Positives = 222/435 (51%), Gaps = 107/435 (24%)

Query: 83  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLG--------------- 127
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 128 ----------------------DEALAAFR---EDEGCLPEGGEDEKPLPSQPFQRQVWL 162
                                 DE LAA R   ED   L  GG D K    +  Q ++W 
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGL--GGPDGKSGRWRRLQPRMWA 217

Query: 163 LFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQ 222
           LFE P SS  AR IA  S+  IL+SI  FCLET   F +          ++  PV  G+ 
Sbjct: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVK--------NKTEPVINGTS 269

Query: 223 ---EEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELL 279
              + E + D + T+                               VE +C+VWFTFE L
Sbjct: 270 VVLQYEIETDPALTY-------------------------------VEGVCVVWFTFEFL 298

Query: 280 VRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLA 339
           VR    P+K  F +N++NIID VAI P+++ +G   +  +  +   G             
Sbjct: 299 VRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG------------- 345

Query: 340 ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE- 398
            LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE 
Sbjct: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405

Query: 399 --------ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTI 450
                   +  + + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTI
Sbjct: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465

Query: 451 ALPVPVIVSNFNYFY 465
           A+PVPVIV+NF  +Y
Sbjct: 466 AMPVPVIVNNFGMYY 480


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  242 bits (617), Expect = 7e-64
 Identities = 161/435 (37%), Positives = 222/435 (51%), Gaps = 107/435 (24%)

Query: 83  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLG--------------- 127
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 128 ----------------------DEALAAFR---EDEGCLPEGGEDEKPLPSQPFQRQVWL 162
                                 DE LAA R   ED   L  GG D K    +  Q ++W 
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGL--GGPDGKSGRWRRLQPRMWA 217

Query: 163 LFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQ 222
           LFE P SS  AR IA  S+  IL+SI  FCLET   F +          ++  PV  G+ 
Sbjct: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVK--------NKTEPVINGTS 269

Query: 223 ---EEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELL 279
              + E + D + T+                               VE +C+VWFTFE L
Sbjct: 270 VVLQYEIETDPALTY-------------------------------VEGVCVVWFTFEFL 298

Query: 280 VRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLA 339
           VR    P+K  F +N++NIID VAI P+++ +G   +  +  +   G             
Sbjct: 299 VRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG------------- 345

Query: 340 ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE- 398
            LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE 
Sbjct: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405

Query: 399 --------ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTI 450
                   +  + + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTI
Sbjct: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465

Query: 451 ALPVPVIVSNFNYFY 465
           A+PVPVIV+NF  +Y
Sbjct: 466 AMPVPVIVNNFGMYY 480


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  242 bits (617), Expect = 7e-64
 Identities = 161/435 (37%), Positives = 222/435 (51%), Gaps = 107/435 (24%)

Query: 83  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLG--------------- 127
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 128 ----------------------DEALAAFR---EDEGCLPEGGEDEKPLPSQPFQRQVWL 162
                                 DE LAA R   ED   L  GG D K    +  Q ++W 
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGL--GGPDGKSGRWRRLQPRMWA 217

Query: 163 LFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQ 222
           LFE P SS  AR IA  S+  IL+SI  FCLET   F +          ++  PV  G+ 
Sbjct: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVK--------NKTEPVINGTS 269

Query: 223 ---EEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELL 279
              + E + D + T+                               VE +C+VWFTFE L
Sbjct: 270 VVLQYEIETDPALTY-------------------------------VEGVCVVWFTFEFL 298

Query: 280 VRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLA 339
           VR    P+K  F +N++NIID VAI P+++ +G   +  +  +   G             
Sbjct: 299 VRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG------------- 345

Query: 340 ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE- 398
            LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE 
Sbjct: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405

Query: 399 --------ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTI 450
                   +  + + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTI
Sbjct: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465

Query: 451 ALPVPVIVSNFNYFY 465
           A+PVPVIV+NF  +Y
Sbjct: 466 AMPVPVIVNNFGMYY 480


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  223 bits (567), Expect = 4e-58
 Identities = 153/500 (30%), Positives = 237/500 (47%), Gaps = 116/500 (23%)

Query: 45  INISGLRFETQLRTLSLFPDTLLGD----PGRRVRF-----FDPLRNEYFFDRNRPSFDA 95
           IN+ G +   +  TL  FP+T LG       R         +D ++ E++FDRN   F  
Sbjct: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80

Query: 96  ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGD--------------------EALAAFR 135
           +L++Y +G +L     + +  F +EI ++ + +                    E      
Sbjct: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139

Query: 136 EDEGCLPEGGE------DEKPLPSQP---FQRQVWLLFEYPESSGPARGIAIVSVLVILI 186
           + E       E      D      QP   F+RQ+WL  + P  S  +R  +I+S+LV++ 
Sbjct: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199

Query: 187 SIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTG 246
           SI+  CL +LP F++    GN                                PGE    
Sbjct: 200 SIITMCLNSLPDFQIPDSQGN--------------------------------PGE---- 223

Query: 247 GSSSLSTLGGSFFTDPFF-LVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIF 305
                         DP F +VE   I WFTFEL+ RF+  P    FF+N +N+IDL++I 
Sbjct: 224 --------------DPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIV 269

Query: 306 PYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQIL 365
           P++ITL   LV +     A+ G            + +V+RL+R+FRI KL+RHS GL+ L
Sbjct: 270 PFYITLVVNLVVESTPTLANLG-----------RVAQVLRLMRIFRILKLARHSTGLRSL 318

Query: 366 GKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGY 425
           G TL+ S +E+GLL+ +L +G+ +FS   Y  E ++++ L  +IP  +WWA V+MTTVGY
Sbjct: 319 GATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGL-ATIPACWWWATVSMTTVGY 377

Query: 426 GDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQP 485
           GD+ P T  GK+  S C +AG+L + LP+ +I + F++FY R+ + E             
Sbjct: 378 GDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESA----------- 426

Query: 486 APDLRATDNGLGKPDFPEAN 505
              +R+ D G G  + P  N
Sbjct: 427 ---MRSCDFGDGMKEVPSVN 443


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  219 bits (558), Expect = 5e-57
 Identities = 146/475 (30%), Positives = 236/475 (49%), Gaps = 92/475 (19%)

Query: 39  SSERLVINISGLRFETQLRTLSLFPDTLLG--------DPGRRV-RFFDPLRNEYFFDRN 89
           S E L +N+ G+R +   R L+ FP T LG        +  RR+   +D    E++FDR+
Sbjct: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRH 107

Query: 90  RPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAA-----FREDEGCLPEG 144
              F ++L++Y++G  L     + +  F +E  ++ LG+ ALAA     + E     P  
Sbjct: 108 PGFFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHA 166

Query: 145 GEDEKPLPSQP------------------------FQRQVWLLFEYPESSGPARGIAIVS 180
            +++   PS                           +R++WL  E P  S P++  + VS
Sbjct: 167 WDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVS 226

Query: 181 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP 240
           + V+L SI   C+ +LP+++           + V+ V+ G   E   +D           
Sbjct: 227 ISVVLASIAAMCIHSLPEYQA------REAAAAVAAVAAGRSPEGVRDDPVLR------- 273

Query: 241 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 300
                                    +E  CI WF+FE+  R    PS   FF + +N+ID
Sbjct: 274 ------------------------RLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLID 309

Query: 301 LVAIFPYFITL--GTELVQQQEQQPASGGGGQNGQQAMSLA-ILRVIRLVRVFRIFKLSR 357
           +V++ P+++TL  G  L            G Q G++   L  +++V RL+R+FR+ KL+R
Sbjct: 310 IVSVLPFYLTLLAGVAL------------GDQGGKEFGHLGKVVQVFRLMRIFRVLKLAR 357

Query: 358 HSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAV 417
           HS GL+ LG TL+ S RE+G+L+ +L +GV +FS   Y AE ++D   F +IP  +WW  
Sbjct: 358 HSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FNTIPACWWWGT 416

Query: 418 VTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQE 472
           V+MTTVGYGD+ P+TV GK+  S C + G+L +ALP+ +I + F++FY R+   E
Sbjct: 417 VSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALE 471


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  211 bits (536), Expect = 2e-54
 Identities = 145/477 (30%), Positives = 232/477 (48%), Gaps = 89/477 (18%)

Query: 29  PEAGGGGGCCSSE-RLVINISGLRFETQLRTLSLFPDTLLGD------PGRRVRF----- 76
           PE G      S +  +V+N+ G+R       LS +P+T L +       G    F     
Sbjct: 10  PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDD 69

Query: 77  FDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLG--------- 127
           +DP + E++FDR+  +F  ++  Y  G    +    P+  F  E+ F+++          
Sbjct: 70  YDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPI-CFKNEMDFWKVDLKFLDDCCK 128

Query: 128 -------DEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS 180
                  +E     R  +  L + G D      +  Q+ VW   E PESS PAR +A++S
Sbjct: 129 SHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLS 188

Query: 181 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP 240
            L+IL+S V+ C+ T+P+ +V    GN         V   + E  E              
Sbjct: 189 FLLILVSSVVMCMGTIPELQVLDAEGNR--------VEHPTLENVE-------------- 226

Query: 241 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 300
                                      T CI WFT E L+R  + P+K  F  + MNI+D
Sbjct: 227 ---------------------------TACIGWFTLEYLLRLFSSPNKLHFALSFMNIVD 259

Query: 301 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 360
           ++AI P++++L    +  +  +        N QQA     ++ +R++R+ RIFKL+RHS 
Sbjct: 260 VLAILPFYVSLTLTHLGARMMELT------NVQQA-----VQALRIMRIARIFKLARHSS 308

Query: 361 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM 420
           GLQ L   L+ S +ELGLL+ +L +G+ +FS+  Y  E    ++LF SIP +FWWA++TM
Sbjct: 309 GLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITM 368

Query: 421 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQY 477
           TTVGYGD+YP T  GK+  ++  + GV+ IALP+  I++NF  +Y+++   E   ++
Sbjct: 369 TTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKH 425


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  203 bits (517), Expect = 3e-52
 Identities = 141/486 (29%), Positives = 226/486 (46%), Gaps = 108/486 (22%)

Query: 41  ERLVINISGLRFETQLRTLSLFPDTLLG------DPGRRVRFFDPLR---NEYFFDRNRP 91
           E + +N+ G +      TL  FP T LG           +   D       EY+FDRN  
Sbjct: 15  ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPS 74

Query: 92  SFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGD---EALAAFREDE---------- 138
            F  +L +Y +G +L     + +  F +EI ++ + +   ++  + R  E          
Sbjct: 75  LFRYVLNFYYTG-KLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDW 133

Query: 139 ----------GCLPEGGEDEKPLPS------QPFQRQVWLLFEYPESSGPARGIAIVSVL 182
                         E    EK L           ++++W+  E P     A+ IAI S+ 
Sbjct: 134 DQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLS 193

Query: 183 VILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGE 242
           V+L SIV  C+ ++ +F                      Q E+ + DD            
Sbjct: 194 VVLASIVAMCVHSMSEF----------------------QNEDGEVDDP----------- 220

Query: 243 MGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLV 302
                      L G         VE  CI WFT EL VR +A P +  F++N +NIID V
Sbjct: 221 ----------VLEG---------VEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFV 261

Query: 303 AIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL 362
           +I P++ TL  +  +++ +   + G            +++++RL+R+FRI KL+RHS GL
Sbjct: 262 SIIPFYATLAVDTKEEESEDIENMG-----------KVVQILRLMRIFRILKLARHSVGL 310

Query: 363 QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTT 422
           + LG TL+ S  E+GLL+ FL +G+ +FS  +Y  E DD  S   SIP  +WWA ++MTT
Sbjct: 311 RSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTT 370

Query: 423 VGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTC 482
           VGYGD +P+T+ GK++ S C I G+L +ALP+ +I + F+ +Y ++ + +         C
Sbjct: 371 VGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVD------QC 424

Query: 483 GQPAPD 488
            + AP+
Sbjct: 425 SEDAPE 430


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  202 bits (514), Expect = 6e-52
 Identities = 147/466 (31%), Positives = 221/466 (47%), Gaps = 87/466 (18%)

Query: 42  RLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLR---------NEYFFDRNRPS 92
           R++IN+ G+++     TL  FP T LG       F D L          NE+FFDRN  +
Sbjct: 64  RIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGA 123

Query: 93  FDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAF------------------ 134
           F  IL + ++G +LR    +    F EE+ ++ + ++ L                     
Sbjct: 124 FGTILTFLRAG-KLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVER 182

Query: 135 -REDEGCLPEGGEDEKPLPSQP----FQRQVWLLFEYPESSGPARGIAIVSVLVILISIV 189
             ED+    EG + E P   +       R++  + E P S  P +  A +SVL + ++ V
Sbjct: 183 EEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAV 242

Query: 190 IFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSS 249
              + TLP  R                      EEEE    S   H+             
Sbjct: 243 NLSVSTLPSLR----------------------EEEEQGHCSQMCHN------------- 267

Query: 250 SLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFI 309
                         F+VE++C+ WF+ E L+R    PSK AF R+ + +IDLVAI PY+I
Sbjct: 268 -------------VFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYI 314

Query: 310 TLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTL 369
           TL  +      ++P   G G +    + L +LRV+R +R+  + +L+RHS GLQ LG T 
Sbjct: 315 TLLVDGAAAGRRKP---GAGNSYLDKVGL-VLRVLRALRILYVMRLARHSLGLQTLGLTA 370

Query: 370 QASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSL-FPSIPDAFWWAVVTMTTVGYGDM 428
           +   RE GLL+ FL + + LF+  +Y  E +  DS  F SIP  +WWAV+TMTTVGYGDM
Sbjct: 371 RRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDM 430

Query: 429 YPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQ 474
            P +  G++V     ++G+L +A PV  I   F+  Y  E +QE++
Sbjct: 431 VPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSY-LELKQEQE 475


>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
           isoform 1 [Homo sapiens]
          Length = 436

 Score =  199 bits (506), Expect = 5e-51
 Identities = 140/466 (30%), Positives = 222/466 (47%), Gaps = 87/466 (18%)

Query: 36  GCCSSERLVINISGLRFETQLRTLSLFP----DTLLGDPGRRVRF-----FDPLRNEYFF 86
           G   +  +V+N+ G R+      L  FP      L G    R        +D  RNEYFF
Sbjct: 4   GRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFF 63

Query: 87  DRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFY-----------------QLGDE 129
           DR+  +F  IL Y +  G+LR    +    F  E+ ++                 ++ D 
Sbjct: 64  DRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDT 123

Query: 130 ALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWL-----LFEYPESSGPARGIAIVSVLVI 184
                 ++ G L  G ++ +P  ++    + WL      FE P SS  A+ +A VSV+ +
Sbjct: 124 YTFYSADEPGVL--GRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFV 181

Query: 185 LISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMG 244
           ++S+V+ C  TLP +R                    +  +    DD   +  G  PG   
Sbjct: 182 IVSMVVLCASTLPDWR-------------------NAAADNRSLDDRSRYSAG--PGR-- 218

Query: 245 TGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAI 304
                           +P  ++E +CI WFT E +VRF    +K  F +  +NIIDL+AI
Sbjct: 219 ----------------EPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAI 262

Query: 305 FPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQI 364
            PY+I++   +             G+N Q   +   LRV+R++R+F + KL+RH  GLQ 
Sbjct: 263 TPYYISVLMTVFT-----------GENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQT 311

Query: 365 LGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE----ADDDDSLFPSIPDAFWWAVVTM 420
           LG TL+   RE+ +L+ F+ + + +FS+     E     +  +  F SIP A WW +++M
Sbjct: 312 LGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISM 371

Query: 421 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 466
           TTVGYGDMYP+TV G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 372 TTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417


>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
           isoform 2 [Homo sapiens]
          Length = 425

 Score =  190 bits (483), Expect = 2e-48
 Identities = 136/466 (29%), Positives = 216/466 (46%), Gaps = 98/466 (21%)

Query: 36  GCCSSERLVINISGLRFETQLRTLSLFP----DTLLGDPGRRVRF-----FDPLRNEYFF 86
           G   +  +V+N+ G R+      L  FP      L G    R        +D  RNEYFF
Sbjct: 4   GRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFF 63

Query: 87  DRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFY-----------------QLGDE 129
           DR+  +F  IL Y +  G+LR    +    F  E+ ++                 ++ D 
Sbjct: 64  DRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDT 123

Query: 130 ALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWL-----LFEYPESSGPARGIAIVSVLVI 184
                 ++ G L  G ++ +P  ++    + WL      FE P SS  A+ +A VSV+ +
Sbjct: 124 YTFYSADEPGVL--GRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFV 181

Query: 185 LISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMG 244
           ++S+V+ C  TLP +                   R +  +    DD              
Sbjct: 182 IVSMVVLCASTLPDW-------------------RNAAADNRSLDDRSR----------- 211

Query: 245 TGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAI 304
                               ++E +CI WFT E +VRF    +K  F +  +NIIDL+AI
Sbjct: 212 --------------------IIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAI 251

Query: 305 FPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQI 364
            PY+I++   +             G+N Q   +   LRV+R++R+F + KL+RH  GLQ 
Sbjct: 252 TPYYISVLMTVFT-----------GENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQT 300

Query: 365 LGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE----ADDDDSLFPSIPDAFWWAVVTM 420
           LG TL+   RE+ +L+ F+ + + +FS+     E     +  +  F SIP A WW +++M
Sbjct: 301 LGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISM 360

Query: 421 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 466
           TTVGYGDMYP+TV G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 361 TTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 406


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.141    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,296,344
Number of Sequences: 37866
Number of extensions: 1116757
Number of successful extensions: 4236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 3681
Number of HSP's gapped (non-prelim): 401
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.