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Search of human proteins with 4504699
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504699 inhibin beta A precursor [Homo sapiens]
(426 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504699 inhibin beta A precursor [Homo sapiens] 871 0.0
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 332 5e-91
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 199 5e-51
gi|13899338 activin beta E [Homo sapiens] 171 1e-42
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 122 5e-28
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 112 6e-25
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 109 5e-24
gi|4885259 myostatin [Homo sapiens] 108 1e-23
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 106 4e-23
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 103 2e-22
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 103 4e-22
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 103 4e-22
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 103 4e-22
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 102 5e-22
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 102 9e-22
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 102 9e-22
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 102 9e-22
gi|110349792 growth differentiation factor 1 [Homo sapiens] 101 1e-21
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 100 3e-21
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 93 5e-19
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 93 5e-19
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 92 9e-19
gi|63025222 transforming growth factor, beta 1 [Homo sapiens] 90 3e-18
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 88 1e-17
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 88 1e-17
gi|222352098 nodal precursor [Homo sapiens] 86 5e-17
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 84 2e-16
gi|7705308 growth differentiation factor 2 [Homo sapiens] 79 6e-15
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 77 2e-14
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 68 1e-11
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 871 bits (2250), Expect = 0.0
Identities = 426/426 (100%), Positives = 426/426 (100%)
Query: 1 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK 60
MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK
Sbjct: 1 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK 60
Query: 61 HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT 120
HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT
Sbjct: 61 HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT 120
Query: 121 SEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQK 180
SEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQK
Sbjct: 121 SEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQK 180
Query: 181 HPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDV 240
HPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDV
Sbjct: 181 HPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDV 240
Query: 241 RIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQS 300
RIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQS
Sbjct: 241 RIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQS 300
Query: 301 EDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG 360
EDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG
Sbjct: 301 EDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG 360
Query: 361 TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIV 420
TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIV
Sbjct: 361 TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIV 420
Query: 421 EECGCS 426
EECGCS
Sbjct: 421 EECGCS 426
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 332 bits (850), Expect = 5e-91
Identities = 177/413 (42%), Positives = 254/413 (61%), Gaps = 56/413 (13%)
Query: 22 PTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKA 81
P PGS G S C SC P+++ + +EAVK+HIL+ L ++ RP++T VPKA
Sbjct: 43 PPPGSPGGSQ-DTCTSCGGFRRPEELGRVDGDFLEAVKRHILSRLQMRGRPNITHAVPKA 101
Query: 82 ALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAES---GTARKTLHF 138
A++ A+RKLH GKV E+G VEI G + + E+ SEII+FAE+ ++R L+F
Sbjct: 102 AMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLYF 161
Query: 139 EISKEGSDLSVVERAEVWLFLK-----VPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAE 193
IS EG+ V +A +WL+LK + K +R + +V + FQ+Q H
Sbjct: 162 FISNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKV-YFQEQGH------------ 208
Query: 194 EVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGAS 253
G+R ++ EK VD ++S WH FP++ +IQ L ++G+ L++ + C+ CQE
Sbjct: 209 -----GDRWNMV--EKRVDLKRSGWHTFPLTEAIQALFERGERRLNLDVQCDSCQELAVV 261
Query: 254 LVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLE 313
V + + E+SHRPF+++QAR D HR R+RGLE
Sbjct: 262 PVFV-------------------------DPGEESHRPFVVVQARLG-DSRHRIRKRGLE 295
Query: 314 CDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVI 373
CDG+ N+CC++QFF+ F+ IGWNDWIIAP+GY+ NYCEG CP+++AG GS+ SFH+ V+
Sbjct: 296 CDGRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVV 355
Query: 374 NHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
N YRMRG +P + SCC+PTKL MSMLY+DD NI+K+D+ NMIVEECGC+
Sbjct: 356 NQYRMRGLNP-GTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 199 bits (505), Expect = 5e-51
Identities = 126/401 (31%), Positives = 197/401 (49%), Gaps = 75/401 (18%)
Query: 31 AAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKL 90
A CP+C L ++ + + +++ K+ IL+ LHL +RP + +PV +AAL A++ L
Sbjct: 22 AGGQCPACGGPTL--ELESQRELLLDLAKRSILDKLHLTQRPTLNRPVSRAALRTALQHL 79
Query: 91 HVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTA-----RKTLHFEISKEGS 145
H + + A + + EQ EII+FAE+G + R HF +
Sbjct: 80 H--------------GVPQGALLEDNREQECEIISFAETGLSTINQTRLDFHFSSDRTAG 125
Query: 146 DLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELL 205
D V ++A + F+++P KV + + G +T + L
Sbjct: 126 DREV-QQASLMFFVQLPSNTTWTLKVRVLVL-------GPHNT-------------NLTL 164
Query: 206 LSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEE 265
++ +++ S WH P+ Q QG +L++ + + Q S V+LG
Sbjct: 165 ATQYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEGQVAQSS----VILG------- 213
Query: 266 EGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQ 325
GA +HRPF+ + R H + RRG++C G +CC+++
Sbjct: 214 --------------GA------AHRPFVAARVRVGGKH--QIHRRGIDCQGGSRMCCRQE 251
Query: 326 FFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFA 385
FFV F++IGW+DWII P GY N+C G+CP HIAG G + SFH+ V+N + +
Sbjct: 252 FFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTT 311
Query: 386 NLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
SCCVPT RP+S+LYYD NI+K DI +M+VE CGCS
Sbjct: 312 GGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 171 bits (433), Expect = 1e-42
Identities = 127/420 (30%), Positives = 196/420 (46%), Gaps = 83/420 (19%)
Query: 11 LASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMV-EAVKKHILNMLHLK 69
L W +VR+ T GS CPSC + L P ++ +V E K+ IL+ LHL
Sbjct: 10 LVLLWALVRAQGT-GSV-------CPSCGGSKL---APQAERALVLELAKQQILDGLHLT 58
Query: 70 KRPDVTQPVPKAALLNAIRKLHVGKVGE-NGYVEIEDDIGRRAEMNELMEQTSEIITFAE 128
RP +T P P+AAL A+R+L G V NG +++ A + + S ++TF
Sbjct: 59 SRPRITHPPPQAALTRALRRLQPGSVAPGNG-----EEVISFATVTDSTSAYSSLLTFHL 113
Query: 129 SGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQ--QQKHPQGSL 186
S L+ A +WL + +P T + +R+F+ ++ QGS
Sbjct: 114 STPRSHHLY--------------HARLWLHV-LPTLPGT---LCLRIFRWGPRRRRQGS- 154
Query: 187 DTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQ 246
LL+E + WH + SS L + L +++ C
Sbjct: 155 ----------------RTLLAEHHIT--NLGWHTLTLPSS--GLRGEKSGVLKLQLDCRP 194
Query: 247 CQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHR 306
+ G S V ++ + G +PFL L+ R +E R
Sbjct: 195 LE--GNSTVTGQPRRLLDTAGH--------------------QQPFLELKIRANEPGAGR 232
Query: 307 RRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSL 366
RRR C+ +CC++ +V F+++GW DWI+ P GY NYC G+CP H+AG+ G +
Sbjct: 233 ARRRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAA 292
Query: 367 SFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
SFHS V + ++ ++P+ SCCVPT RP+S+LY D N++K D+ +M+VE CGCS
Sbjct: 293 SFHSAVFS--LLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS 350
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 122 bits (307), Expect = 5e-28
Identities = 106/426 (24%), Positives = 174/426 (40%), Gaps = 89/426 (20%)
Query: 33 PDCPSCALAALPKDVPNSQP--EMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKL 90
P+ AA P+SQP E++ + +L+M LK+RP ++ + + +
Sbjct: 26 PELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRR 85
Query: 91 HVGKVG-----------------------ENGYVEIEDDIG---RRAEMNELMEQTSEII 124
H G+ G E E+ + G RR N T E I
Sbjct: 86 HSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFI 145
Query: 125 TFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQG 184
T AE R+ + + G++ S R ++ +K AN ++ VT
Sbjct: 146 TSAELQVFREQMQDAL---GNNSSFHHRINIYEIIKPATAN-SKFPVT------------ 189
Query: 185 SLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIAC 244
LL ++V+ S W F V+ ++ R QG ++ +
Sbjct: 190 -------------------RLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEV 230
Query: 245 EQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHP 304
+E ++G K+ DE RP L+ + HP
Sbjct: 231 AHLEE---------------KQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHP 275
Query: 305 -HRRRRRGLECDGKVNI---CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG 360
H+R +R + + + C + +V F D+GWNDWI+AP GYHA YC GECP +A
Sbjct: 276 LHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLAD 335
Query: 361 -TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMI 419
+ ++ + T++N + K+CCVPT+L +SMLY D+ + ++ K+ Q+M+
Sbjct: 336 HLNSTNHAIVQTLVNSVNSK------IPKACCVPTELSAISMLYLDENEKVVLKNYQDMV 389
Query: 420 VEECGC 425
VE CGC
Sbjct: 390 VEGCGC 395
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 112 bits (280), Expect = 6e-25
Identities = 116/423 (27%), Positives = 181/423 (42%), Gaps = 80/423 (18%)
Query: 20 SSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPV- 78
S P P S AP+ C + + +S+ +E++K IL+ L LK+ P++++ V
Sbjct: 49 SRPAP-----SVAPEPDGCPVCVWRQ---HSRELRLESIKSQILSKLRLKEAPNISREVV 100
Query: 79 ----PKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFA-ESGTAR 133
PKA L I LH + ++ ED + E +E T +I+ A E+ A
Sbjct: 101 KQLLPKAPPLQQILDLHDF---QGDALQPEDFL----EEDEYHATTETVISMAQETDPAV 153
Query: 134 KT------LHFEISKEGSDLSVVERAEVWLFLK-VPKANRTRTKVTIRLFQQQKHPQGSL 186
+T HF S + V+ +A++W++L+ VP+ T+ L + P
Sbjct: 154 QTDGSPLCCHFHFSPKVMFTKVL-KAQLWVYLRPVPRP------ATVYLQILRLKPL--- 203
Query: 187 DTGEEAEEVGLKGERSELLLSEKV-VDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACE 245
TGE G G R + S K+ + +R W + Q +S+ + I
Sbjct: 204 -TGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAF 262
Query: 246 QCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPH 305
+ ++ LG G EG PF+ L R E+
Sbjct: 263 DPSGTDLAVTSLGP--------------GAEG-----------LHPFMEL--RVLENTKR 295
Query: 306 RRRRRGLECD--GKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSG 363
RR GL+CD + CC+ V F+ GW DWIIAP Y ANYC G+C
Sbjct: 296 SRRNLGLDCDEHSSESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQC--------- 345
Query: 364 SSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEEC 423
F + + ++ +P + CC PTK+ P++MLY++D Q II I M+V+ C
Sbjct: 346 -EYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRC 404
Query: 424 GCS 426
GCS
Sbjct: 405 GCS 407
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 109 bits (272), Expect = 5e-24
Identities = 53/143 (37%), Positives = 84/143 (58%), Gaps = 15/143 (10%)
Query: 289 HRPFLMLQARQSEDHPHRRRRRG-----LECDGKVNICCKKQFFVSFKDIGWNDWIIAPS 343
H L++ + HP R+RR L C N+C + Q F++F+D+GW+ WIIAP
Sbjct: 230 HASLLVVTLNPDQCHPSRKRRAAIPVPKLSCK---NLCHRHQLFINFRDLGWHKWIIAPK 286
Query: 344 GYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANL-KSCCVPTKLRPMSML 402
G+ ANYC GECP + ++S +S+ + H+ + ++ C+PTKL P+SML
Sbjct: 287 GFMANYCHGECPFSL------TISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISML 340
Query: 403 YYDDGQNIIKKDIQNMIVEECGC 425
Y D+ N+I + ++M+V+ECGC
Sbjct: 341 YQDNNDNVILRHYEDMVVDECGC 363
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 108 bits (269), Expect = 1e-23
Identities = 101/386 (26%), Positives = 165/386 (42%), Gaps = 65/386 (16%)
Query: 49 NSQPEMVEAVKKHILNMLHLKKRPDVTQPV-----PKAALLNAIRKLHVGKVGENGYVEI 103
N++ +EA+K IL+ L L+ P++++ V PKA L + + + ++ +
Sbjct: 47 NTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSL 106
Query: 104 EDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPK 163
EDD A ++ +E + K F+ S + VV +A++W++L+ +
Sbjct: 107 EDD-DYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVV-KAQLWIYLRPVE 164
Query: 164 ANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPV 223
T +RL + K G+ TG + ++ + + W V
Sbjct: 165 TPTTVFVQILRLIKPMK--DGTRYTGIRSLKLDM--------------NPGTGIWQSIDV 208
Query: 224 SSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADE 283
+ +Q L Q +S+L + I + E+G L + G GE G
Sbjct: 209 KTVLQNWLKQPESNLGIEI--KALDENGHDLAVTFP-------------GPGEDGLN--- 250
Query: 284 EKEQSHRPFLMLQARQSEDHPHRRRRR-GLECD--GKVNICCKKQFFVSFKDIGWNDWII 340
PFL ++ D P R RR GL+CD + CC+ V F+ GW DWII
Sbjct: 251 -------PFLEVKVT---DTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGW-DWII 299
Query: 341 APSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMS 400
AP Y ANYC GEC F + + + +P + CC PTK+ P++
Sbjct: 300 APKRYKANYCSGEC----------EFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPIN 349
Query: 401 MLYYDDGQNIIKKDIQNMIVEECGCS 426
MLY++ + II I M+V+ CGCS
Sbjct: 350 MLYFNGKEQIIYGKIPAMVVDRCGCS 375
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 106 bits (265), Expect = 4e-23
Identities = 101/407 (24%), Positives = 180/407 (44%), Gaps = 51/407 (12%)
Query: 46 DVPNSQPEMVEAVKKHILNMLHLKKRPDVTQ----PVPKAALLNAIRKL--------HVG 93
D + + + VEA++ IL+ L L P+ T P AL N+ R+L G
Sbjct: 31 DFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEG 90
Query: 94 KVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERA 153
EN E + +M + + + +E+ G K F +S + + + RA
Sbjct: 91 CTQENTESEYYAKEIHKFDMIQGLAEHNELAV-CPKGITSKVFRFNVSSVEKNRTNLFRA 149
Query: 154 EVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDA 213
E + L+VP + R + I LFQ + + + + + +
Sbjct: 150 E-FRVLRVPNPSSKRNEQRIELFQILRPDEHIA--------------KQRYIGGKNLPTR 194
Query: 214 RKSTWHVFPVSSSIQRLLDQGKSSLDVRIA----CEQCQESGASLVLLGKKKKKEEEGEG 269
+ W F V+ +++ L + +S+L + I+ C Q +G L + + + + +G
Sbjct: 195 GTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVD 254
Query: 270 KKKGGGEGGAGADEEKEQSHRPFLMLQARQSE--DHPHR---RRRRGLECD----GKVNI 320
+ G G G ++++ H P L+L D+P + R++R L+ +
Sbjct: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314
Query: 321 CCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMR 379
CC + ++ F+ D+GW W+ P GY+AN+C G CP S+ + HSTV+ Y
Sbjct: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCP-----YLRSADTTHSTVLGLYNTL 368
Query: 380 GHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 426
+P A+ CCVP L P+++LYY G+ + + NM+V+ C CS
Sbjct: 369 --NPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKCS 412
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 103 bits (258), Expect = 2e-22
Identities = 107/436 (24%), Positives = 171/436 (39%), Gaps = 56/436 (12%)
Query: 4 LWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHIL 63
LWL G L + G G P CP L A + V++ IL
Sbjct: 8 LWLLGLTLCALG--------GGGPGLRPPPGCPQRRLGARER----------RDVQREIL 49
Query: 64 NMLHLKKRPDVTQP-----VPKAALLNAIRKLHV--GKVGENGYVEIEDDIGRRAEMNEL 116
+L L RP P +P +A L + H G E+G E +GR +
Sbjct: 50 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDG-APAEQRLGRADLVMSF 108
Query: 117 MEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKA---NRTRTKVTI 173
+ K F++++ + +V A + KVP NRT
Sbjct: 109 VNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVT--AAEFRIYKVPSIHLLNRTLHVSMF 166
Query: 174 RLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQ 233
++ Q+Q + + L L + + A W V V+++ L +
Sbjct: 167 QVVQEQSNRESDL-----------------FFLDLQTLRAGDEGWLVLDVTAASDCWLLK 209
Query: 234 GKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFL 293
L +R+ E L G ++ + + + ++ RP
Sbjct: 210 RHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLR 269
Query: 294 MLQARQSEDHPHRRRRRGLECDGKVN----ICCKKQFFVSFKDIGWNDWIIAPSGYHANY 349
Q ++S + P R G+ D + + +C + + +VSF+D+GW DW+IAP GY A Y
Sbjct: 270 RRQPKKSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYY 329
Query: 350 CEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQN 409
CEGEC + S ++ + I + P A K+CC PTKL S+LYYD N
Sbjct: 330 CEGECSFPL----DSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNN 385
Query: 410 IIKKDIQNMIVEECGC 425
+I + +NM+V+ CGC
Sbjct: 386 VILRKHRNMVVKACGC 401
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 103 bits (256), Expect = 4e-22
Identities = 49/109 (44%), Positives = 64/109 (58%), Gaps = 12/109 (11%)
Query: 321 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRG 380
C K + +VSF+D+GW DWIIAP GY ANYC+GEC L+ H NH ++
Sbjct: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGEC--------SFPLNAHMNATNHAIVQT 463
Query: 381 ----HSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
+P K CC PTKL +S+LY+DD N+I K +NM+V CGC
Sbjct: 464 LVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 103 bits (256), Expect = 4e-22
Identities = 68/183 (37%), Positives = 91/183 (49%), Gaps = 13/183 (7%)
Query: 252 ASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLML-QARQSEDHPHRRRRR 310
A LV+ + ++K E +++ G AG E S P AR P RRRRR
Sbjct: 276 ALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRR 335
Query: 311 -------GLECDGKVNI-CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTS 362
G K + C KK V+FK++GW+DWIIAP Y A +CEG C +
Sbjct: 336 TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLR--- 392
Query: 363 GSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEE 422
S L + I M P + SCCVPTKL P+S+LY D G N++ K ++M+VE
Sbjct: 393 -SHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVES 451
Query: 423 CGC 425
CGC
Sbjct: 452 CGC 454
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 103 bits (256), Expect = 4e-22
Identities = 108/437 (24%), Positives = 170/437 (38%), Gaps = 58/437 (13%)
Query: 4 LWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHIL 63
LWL G L + G G P CP L A + V++ IL
Sbjct: 8 LWLLGLALCALG--------GGGPGLRPPPGCPQRRLGARER----------RDVQREIL 49
Query: 64 NMLHLKKRPDVTQP-----VPKAALLNAIRKLHV--GKVGENGYVEIEDDIGRRAEMNEL 116
+L L RP P +P +A L + H G E+G E +GR +
Sbjct: 50 AVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDG-APAERRLGRADLVMSF 108
Query: 117 MEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKA---NRTRTKVTI 173
+ K F++++ + +V A + KVP NRT
Sbjct: 109 VNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVT--AAEFRIYKVPSIHLLNRTLHVSMF 166
Query: 174 RLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQ 233
++ Q+Q + + L L + + A W V V+++ L +
Sbjct: 167 QVVQEQSNRESDL-----------------FFLDLQTLRAGDEGWLVLDVTAASDCWLLK 209
Query: 234 GKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFL 293
L +R+ E L G ++ + + + ++ RP
Sbjct: 210 RHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLR 269
Query: 294 MLQARQSEDHPHRRRRRGLECD-----GKVNICCKKQFFVSFKDIGWNDWIIAPSGYHAN 348
Q ++S + P R G+ D G+ +C + + +VSF+D+GW DW+IAP GY A
Sbjct: 270 RRQPKKSNELPQANRLPGIFDDVHGSHGR-QVCRRHELYVSFQDLGWLDWVIAPQGYSAY 328
Query: 349 YCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQ 408
YCEGEC + ++ + H M P A K+CC PTKL S+LYYD
Sbjct: 329 YCEGECSFPLDSCMNATNHAILQSLVHLMM----PDAVPKACCAPTKLSATSVLYYDSSN 384
Query: 409 NIIKKDIQNMIVEECGC 425
N+I + +NM+V+ CGC
Sbjct: 385 NVILRKHRNMVVKACGC 401
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 102 bits (255), Expect = 5e-22
Identities = 46/105 (43%), Positives = 61/105 (58%), Gaps = 4/105 (3%)
Query: 321 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRG 380
C K + +VSF+D+GW DWIIAP GY A YC+GEC + ++ + H
Sbjct: 353 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPD 412
Query: 381 HSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
H P K CC PTKL +S+LY+DD N+I K +NM+V CGC
Sbjct: 413 HVP----KPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 102 bits (253), Expect = 9e-22
Identities = 99/396 (25%), Positives = 165/396 (41%), Gaps = 63/396 (15%)
Query: 53 EMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAE 112
E++ + +L M L++RP QP A + + +R L+ + GE E
Sbjct: 52 ELLRDFEATLLQMFGLRRRP---QPSKSAVIPDYMRDLYRLQSGE--------------E 94
Query: 113 MNELMEQTSEIITFAESGTAR----KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRT 167
E + T + + E +R ++ H E E + A +LF L N
Sbjct: 95 EEEQIHSTG--LEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV 152
Query: 168 RTKVTIRLFQQQKHPQGSLDTG----------EEAEEVGLKGERSELLLSEKVVDARKST 217
+ +RLF++Q + G + EV + G LL ++V +
Sbjct: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEV-VPGHLITRLLDTRLVHHNVTR 211
Query: 218 WHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKG---- 273
W F VS ++ R + + + + I ++ + + +G G
Sbjct: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271
Query: 274 ---GGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSF 330
G G G H +A++S H +R R+ K C + +V F
Sbjct: 272 LVTFGHDGRG--------HALTRRRRAKRSPKHHSQRARK------KNKNCRRHSLYVDF 317
Query: 331 KDIGWNDWIIAPSGYHANYCEGECPSHIAG-TSGSSLSFHSTVINHYRMRGHSPFANLKS 389
D+GWNDWI+AP GY A YC G+CP +A + ++ + T++N + P K+
Sbjct: 318 SDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN--SVNSSIP----KA 371
Query: 390 CCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
CCVPT+L +SMLY D+ ++ K+ Q M+VE CGC
Sbjct: 372 CCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 102 bits (253), Expect = 9e-22
Identities = 99/396 (25%), Positives = 165/396 (41%), Gaps = 63/396 (15%)
Query: 53 EMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAE 112
E++ + +L M L++RP QP A + + +R L+ + GE E
Sbjct: 52 ELLRDFEATLLQMFGLRRRP---QPSKSAVIPDYMRDLYRLQSGE--------------E 94
Query: 113 MNELMEQTSEIITFAESGTAR----KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRT 167
E + T + + E +R ++ H E E + A +LF L N
Sbjct: 95 EEEQIHSTG--LEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV 152
Query: 168 RTKVTIRLFQQQKHPQGSLDTG----------EEAEEVGLKGERSELLLSEKVVDARKST 217
+ +RLF++Q + G + EV + G LL ++V +
Sbjct: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEV-VPGHLITRLLDTRLVHHNVTR 211
Query: 218 WHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKG---- 273
W F VS ++ R + + + + I ++ + + +G G
Sbjct: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271
Query: 274 ---GGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSF 330
G G G H +A++S H +R R+ K C + +V F
Sbjct: 272 LVTFGHDGRG--------HALTRRRRAKRSPKHHSQRARK------KNKNCRRHSLYVDF 317
Query: 331 KDIGWNDWIIAPSGYHANYCEGECPSHIAG-TSGSSLSFHSTVINHYRMRGHSPFANLKS 389
D+GWNDWI+AP GY A YC G+CP +A + ++ + T++N + P K+
Sbjct: 318 SDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN--SVNSSIP----KA 371
Query: 390 CCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
CCVPT+L +SMLY D+ ++ K+ Q M+VE CGC
Sbjct: 372 CCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 102 bits (253), Expect = 9e-22
Identities = 99/396 (25%), Positives = 165/396 (41%), Gaps = 63/396 (15%)
Query: 53 EMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAE 112
E++ + +L M L++RP QP A + + +R L+ + GE E
Sbjct: 52 ELLRDFEATLLQMFGLRRRP---QPSKSAVIPDYMRDLYRLQSGE--------------E 94
Query: 113 MNELMEQTSEIITFAESGTAR----KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRT 167
E + T + + E +R ++ H E E + A +LF L N
Sbjct: 95 EEEQIHSTG--LEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEV 152
Query: 168 RTKVTIRLFQQQKHPQGSLDTG----------EEAEEVGLKGERSELLLSEKVVDARKST 217
+ +RLF++Q + G + EV + G LL ++V +
Sbjct: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEV-VPGHLITRLLDTRLVHHNVTR 211
Query: 218 WHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKG---- 273
W F VS ++ R + + + + I ++ + + +G G
Sbjct: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271
Query: 274 ---GGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSF 330
G G G H +A++S H +R R+ K C + +V F
Sbjct: 272 LVTFGHDGRG--------HALTRRRRAKRSPKHHSQRARK------KNKNCRRHSLYVDF 317
Query: 331 KDIGWNDWIIAPSGYHANYCEGECPSHIAG-TSGSSLSFHSTVINHYRMRGHSPFANLKS 389
D+GWNDWI+AP GY A YC G+CP +A + ++ + T++N + P K+
Sbjct: 318 SDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN--SVNSSIP----KA 371
Query: 390 CCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
CCVPT+L +SMLY D+ ++ K+ Q M+VE CGC
Sbjct: 372 CCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 101 bits (252), Expect = 1e-21
Identities = 47/128 (36%), Positives = 77/128 (60%), Gaps = 7/128 (5%)
Query: 303 HPHRRRRRGLEC---DGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGEC--PSH 357
HP R RR E G C ++ +VSF+++GW+ W+IAP G+ ANYC+G+C P
Sbjct: 246 HPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVA 305
Query: 358 IAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQN 417
++G+ G H+ + M +P A CCVP +L P+S+L++D+ N++ + ++
Sbjct: 306 LSGSGGPPALNHAVL--RALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYED 363
Query: 418 MIVEECGC 425
M+V+ECGC
Sbjct: 364 MVVDECGC 371
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 100 bits (248), Expect = 3e-21
Identities = 48/109 (44%), Positives = 63/109 (57%), Gaps = 12/109 (11%)
Query: 321 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRG 380
C K + +VSF+D+GW DWIIAP GY A YCEGEC L+ + NH ++
Sbjct: 330 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGEC--------AFPLNSYMNATNHAIVQT 381
Query: 381 HSPFAN----LKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
F N K CC PT+L +S+LY+DD N+I K +NM+V CGC
Sbjct: 382 LVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 92.8 bits (229), Expect = 5e-19
Identities = 59/187 (31%), Positives = 86/187 (45%), Gaps = 22/187 (11%)
Query: 243 ACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSED 302
A Q E LV KK+ E K + G + + Q + L RQ +
Sbjct: 332 AARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKR 391
Query: 303 HPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECP----SHI 358
+ R C +K V+FKD+GW+DWIIAP Y A +CEG C SH+
Sbjct: 392 PSKNLKAR----------CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL 441
Query: 359 AGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNM 418
T+ H+ + M P + +CCVPT+L P+S+L+ D N++ K ++M
Sbjct: 442 EPTN------HAVI--QTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDM 493
Query: 419 IVEECGC 425
+VE CGC
Sbjct: 494 VVESCGC 500
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 92.8 bits (229), Expect = 5e-19
Identities = 76/259 (29%), Positives = 107/259 (41%), Gaps = 44/259 (16%)
Query: 198 KGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSS--LDVRIACEQCQESGASLV 255
+GER+ L+L + S W F V+ +I+R G S+ L+V I + + AS
Sbjct: 178 EGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSG 237
Query: 256 LL----------------------GKKKKKEEEGE--GKKKGGGEGGAGADE-EKEQSHR 290
L K++KEE E ++ G D
Sbjct: 238 RLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEE 297
Query: 291 PFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYC 350
L +++ D R RR + K N C + ++ FK+IGW+ WIIAP GY A C
Sbjct: 298 ALLQMRSNIIYDSTARIRR-----NAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYEC 352
Query: 351 EGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFAN----LKSCCVPTKLRPMSMLYYDD 406
G C L+ H T H ++ N K+CCVPTKL P+S+LY D
Sbjct: 353 RGVC--------NYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK 404
Query: 407 GQNIIKKDIQNMIVEECGC 425
G K + M V ECGC
Sbjct: 405 GVVTYKFKYEGMAVSECGC 423
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 92.0 bits (227), Expect = 9e-19
Identities = 45/109 (41%), Positives = 65/109 (59%), Gaps = 12/109 (11%)
Query: 321 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECP----SHIAGTSGSSLSFHSTVINHY 376
C +K V FK++GW+DWIIAP Y A +CEG C SH+ T+ + + T++N
Sbjct: 349 CSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQ---TLLNSM 405
Query: 377 RMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
+P A SCCVP +L P+S+LY D N++ K ++M+VE CGC
Sbjct: 406 -----APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449
>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
Length = 390
Score = 90.1 bits (222), Expect = 3e-18
Identities = 111/441 (25%), Positives = 176/441 (39%), Gaps = 74/441 (16%)
Query: 4 LWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPK-DVPNSQPEMVEAVKKHI 62
L L LL W++V TPG P+ L+ D+ + + +EA++ I
Sbjct: 6 LRLLPLLLPLLWLLVL---TPGR---------PAAGLSTCKTIDMELVKRKRIEAIRGQI 53
Query: 63 LNMLHLKKRPDVTQ----PVPKA--ALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNEL 116
L+ L L P + P+P+A AL N+ R G+ E D + +
Sbjct: 54 LSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLM 113
Query: 117 MEQTSEIITFAESGTARKTLHF---EISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTI 173
+E +EI + T + F E+ + + ++ RAE+ L R + KV
Sbjct: 114 VETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL-------RLKLKVEQ 166
Query: 174 RLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQ 233
+ QK+ S L + + + W F V+ +++ L +
Sbjct: 167 HVELYQKYSNNSW----------------RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSR 210
Query: 234 GKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFL 293
G R++ +S ++ + G G G +RPFL
Sbjct: 211 GGEIEGFRLSAHCSCDS------------RDNTLQVDINGFTTGRRGDLATIHGMNRPFL 258
Query: 294 MLQARQSEDHPH---RRRRRGLECD----GKVNICCKKQFFVSF-KDIGWNDWIIAPSGY 345
+L A E H R RR L+ + CC +Q ++ F KD+GW WI P GY
Sbjct: 259 LLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGY 317
Query: 346 HANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYD 405
HAN+C G CP S + +S V+ Y H+P A+ CCVP L P+ ++YY
Sbjct: 318 HANFCLGPCP-----YIWSLDTQYSKVLALYNQ--HNPGASAAPCCVPQALEPLPIVYY- 369
Query: 406 DGQNIIKKDIQNMIVEECGCS 426
G+ + + NMIV C CS
Sbjct: 370 VGRKPKVEQLSNMIVRSCKCS 390
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 88.2 bits (217), Expect = 1e-17
Identities = 84/312 (26%), Positives = 139/312 (44%), Gaps = 44/312 (14%)
Query: 134 KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEA 192
+ + F++S + S + +AE +F L+ PKA + I L+Q K + T
Sbjct: 156 RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQR--IELYQILKSKDLTSPT---- 209
Query: 193 EEVGLKGERSELLLSEKVVDAR-KSTWHVFPVSSSIQRLLDQGKSSLDVRIA--CEQCQE 249
+ + KVV R + W F V+ ++ L +L +I+ C C
Sbjct: 210 ----------QRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTF 259
Query: 250 SGASLVLLGKKKKKEE------EGEGKKKGGGEGGAGADEEKEQSHRPFLMLQA----RQ 299
++ ++ K ++ E +G G + + +K P L+L R
Sbjct: 260 VPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRL 319
Query: 300 SEDHPHRRRRRGLE---CDGKV-NICCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGEC 354
+RR++R L+ C V + CC + ++ FK D+GW WI P GY+AN+C G C
Sbjct: 320 ESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 378
Query: 355 PSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKD 414
P SS + HS V++ Y +P A+ CCV L P+++LYY G+ +
Sbjct: 379 P-----YLWSSDTQHSRVLSLYNT--INPEASASPCCVSQDLEPLTILYY-IGKTPKIEQ 430
Query: 415 IQNMIVEECGCS 426
+ NMIV+ C CS
Sbjct: 431 LSNMIVKSCKCS 442
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 88.2 bits (217), Expect = 1e-17
Identities = 84/312 (26%), Positives = 139/312 (44%), Gaps = 44/312 (14%)
Query: 134 KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEA 192
+ + F++S + S + +AE +F L+ PKA + I L+Q K + T
Sbjct: 128 RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQR--IELYQILKSKDLTSPT---- 181
Query: 193 EEVGLKGERSELLLSEKVVDAR-KSTWHVFPVSSSIQRLLDQGKSSLDVRIA--CEQCQE 249
+ + KVV R + W F V+ ++ L +L +I+ C C
Sbjct: 182 ----------QRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTF 231
Query: 250 SGASLVLLGKKKKKEE------EGEGKKKGGGEGGAGADEEKEQSHRPFLMLQA----RQ 299
++ ++ K ++ E +G G + + +K P L+L R
Sbjct: 232 VPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRL 291
Query: 300 SEDHPHRRRRRGLE---CDGKV-NICCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGEC 354
+RR++R L+ C V + CC + ++ FK D+GW WI P GY+AN+C G C
Sbjct: 292 ESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 350
Query: 355 PSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKD 414
P SS + HS V++ Y +P A+ CCV L P+++LYY G+ +
Sbjct: 351 P-----YLWSSDTQHSRVLSLYNT--INPEASASPCCVSQDLEPLTILYY-IGKTPKIEQ 402
Query: 415 IQNMIVEECGCS 426
+ NMIV+ C CS
Sbjct: 403 LSNMIVKSCKCS 414
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 86.3 bits (212), Expect = 5e-17
Identities = 47/123 (38%), Positives = 66/123 (53%), Gaps = 13/123 (10%)
Query: 307 RRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSL 366
+R R + +C K +F V F IGW WII P Y+A CEGECP+ +
Sbjct: 233 KRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGE------ 286
Query: 367 SFHSTVINH----YRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEE 422
FH T NH ++ + P +CC P K +P+SMLY D+G+ ++ ++MIVEE
Sbjct: 287 EFHPT--NHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGR-VLLDHHKDMIVEE 343
Query: 423 CGC 425
CGC
Sbjct: 344 CGC 346
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/167 (29%), Positives = 81/167 (48%), Gaps = 5/167 (2%)
Query: 259 KKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKV 318
KK + EE + K + + +K+Q P Q Q ++ ++ RR + +
Sbjct: 310 KKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRN 369
Query: 319 NICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRM 378
C ++ V F DIGW++WII+P + A YC G C S H+T+ + R
Sbjct: 370 --CARRYLKVDFADIGWSEWIISPKSFDAYYCSGAC--QFPMPKSLKPSNHATIQSIVRA 425
Query: 379 RGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
G P + CCVP K+ +S+L++D+ +N++ K NM VE C C
Sbjct: 426 VGVVP-GIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 79.3 bits (194), Expect = 6e-15
Identities = 54/156 (34%), Positives = 71/156 (45%), Gaps = 17/156 (10%)
Query: 271 KKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSF 330
K G E G + EE H + RR+R G + C K V+F
Sbjct: 289 KDGSTEAGESSHEEDTDGH---------VAAGSTLARRKRSA---GAGSHCQKTSLRVNF 336
Query: 331 KDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSC 390
+DIGW+ WIIAP Y A C+G C +A + + H + P K+C
Sbjct: 337 EDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKF----PTKVGKAC 392
Query: 391 CVPTKLRPMSMLYYDD-GQNIIKKDIQNMIVEECGC 425
CVPTKL P+S+LY DD G +K + M V ECGC
Sbjct: 393 CVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 77.4 bits (189), Expect = 2e-14
Identities = 42/146 (28%), Positives = 71/146 (48%), Gaps = 4/146 (2%)
Query: 280 GADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWI 339
G + +++ F+ D ++ R + D + +C ++ V F DIGWN+WI
Sbjct: 336 GRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWD-EPRVCSRRYLKVDFADIGWNEWI 394
Query: 340 IAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPM 399
I+P + A YC G C + S H+T+ + R G P + CCVP K+ +
Sbjct: 395 ISPKSFDAYYCAGACEFPMPKIVRP--SNHATIQSIVRAVGIIP-GIPEPCCVPDKMNSL 451
Query: 400 SMLYYDDGQNIIKKDIQNMIVEECGC 425
+L+ D+ +N++ K NM V+ C C
Sbjct: 452 GVLFLDENRNVVLKVYPNMSVDTCAC 477
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 68.2 bits (165), Expect = 1e-11
Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 28/169 (16%)
Query: 280 GADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKV--------------------- 318
G D+E+ S P + +A + H R RRG E
Sbjct: 290 GPDQERSLSAYP-VGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLL 348
Query: 319 --NICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHY 376
N C F +SF + W++WI+AP Y+ YC+G+CP + GS + I +
Sbjct: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
Query: 377 RMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
++ P + CVP K P+S+L + +I K+ ++MI +C C
Sbjct: 409 KLDSSVP----RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,810,920
Number of Sequences: 37866
Number of extensions: 886761
Number of successful extensions: 4828
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 4578
Number of HSP's gapped (non-prelim): 216
length of query: 426
length of database: 18,247,518
effective HSP length: 105
effective length of query: 321
effective length of database: 14,271,588
effective search space: 4581179748
effective search space used: 4581179748
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.