Search of human proteins with 4503645

Search of human proteins with 4503645

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503645 coagulation factor VII isoform a precursor [Homo
sapiens]
         (466 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503645 coagulation factor VII isoform a precursor [Homo sapi...   984   0.0  
gi|10518503 coagulation factor VII isoform b precursor [Homo sap...   922   0.0  
gi|4503625 coagulation factor X preproprotein [Homo sapiens]          355   6e-98
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         350   1e-96
gi|4506115 protein C [Homo sapiens]                                   311   1e-84
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             173   3e-43
gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [H...   172   6e-43
gi|4506153 prostasin preproprotein [Homo sapiens]                     169   4e-42
gi|4503627 coagulation factor XI precursor [Homo sapiens]             167   1e-41
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           167   2e-41
gi|223942069 enterokinase precursor [Homo sapiens]                    159   4e-39
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   159   5e-39
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   159   5e-39
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           158   9e-39
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]           154   2e-37
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         152   6e-37
gi|4504383 HGF activator preproprotein [Homo sapiens]                 152   8e-37
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       149   5e-36
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        149   5e-36
gi|110578663 hypothetical protein LOC203074 [Homo sapiens]            149   5e-36
gi|4505881 plasminogen [Homo sapiens]                                 149   7e-36
gi|4503635 coagulation factor II preproprotein [Homo sapiens]         149   7e-36
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   148   9e-36
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   148   9e-36
gi|13994276 marapsin [Homo sapiens]                                   148   1e-35
gi|11545839 protease, serine, 22 [Homo sapiens]                       147   2e-35
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          147   3e-35
gi|33695155 hepsin [Homo sapiens]                                     146   3e-35
gi|4504481 hepsin [Homo sapiens]                                      146   3e-35
gi|58218970 protease, serine, 36 [Homo sapiens]                       146   3e-35

>gi|4503645 coagulation factor VII isoform a precursor [Homo
           sapiens]
          Length = 466

 Score =  984 bits (2544), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR 60
           MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
Sbjct: 1   MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR 60

Query: 61  ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS 120
           ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
Sbjct: 61  ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS 120

Query: 121 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL 180
           CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
Sbjct: 121 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL 180

Query: 181 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG 240
           LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
Sbjct: 181 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG 240

Query: 241 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN 300
           TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
Sbjct: 241 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN 300

Query: 301 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL 360
           HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
Sbjct: 301 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL 360

Query: 361 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG 420
           NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
Sbjct: 361 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG 420

Query: 421 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 466
           IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Sbjct: 421 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 466


>gi|10518503 coagulation factor VII isoform b precursor [Homo
           sapiens]
          Length = 444

 Score =  922 bits (2384), Expect = 0.0
 Identities = 444/466 (95%), Positives = 444/466 (95%), Gaps = 22/466 (4%)

Query: 1   MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR 60
           MVSQALRLLCLLLGLQGCLAA                      VFVTQEEAHGVLHRRRR
Sbjct: 1   MVSQALRLLCLLLGLQGCLAA----------------------VFVTQEEAHGVLHRRRR 38

Query: 61  ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS 120
           ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
Sbjct: 39  ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS 98

Query: 121 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL 180
           CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
Sbjct: 99  CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL 158

Query: 181 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG 240
           LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
Sbjct: 159 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG 218

Query: 241 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN 300
           TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
Sbjct: 219 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN 278

Query: 301 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL 360
           HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
Sbjct: 279 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL 338

Query: 361 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG 420
           NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
Sbjct: 339 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG 398

Query: 421 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 466
           IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Sbjct: 399 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 444


>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
          Length = 488

 Score =  355 bits (910), Expect = 6e-98
 Identities = 181/468 (38%), Positives = 266/468 (56%), Gaps = 59/468 (12%)

Query: 44  VFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWIS 103
           +F+ +E+A+ +L R  RAN+FLEE++ G LEREC EE CS+EEARE+F+D+++T  FW  
Sbjct: 24  LFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNK 83

Query: 104 YSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCS 163
           Y DGDQC +SPCQN G CKD L  Y C CL  FEG+NCE     + +C  +NG C+Q+C 
Sbjct: 84  YKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFT--RKLCSLDNGDCDQFCH 141

Query: 164 DHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQG------------ 211
           +   +   C C  GY+L  +G +C PT  YPCGK   LE+R  S  Q             
Sbjct: 142 EEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QTLERRKRSVAQATSSSGEAPDSIT 199

Query: 212 ----------------------------------RIVGGKVCPKGECPWQVLLLVNGAQ- 236
                                             RIVGG+ C  GECPWQ LL+    + 
Sbjct: 200 WKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEG 259

Query: 237 LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVP 296
            CGGT+++  ++++AAHC  + K ++  +   G+ +  + +G E    V  VI  + +  
Sbjct: 260 FCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNTEQEEGGEAVHEVEVVIKHNRFTK 316

Query: 297 GTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALE 356
            T + DIA+LRL  P+    +V P CLPER ++E TL   +  +VSG+G+  ++G  +  
Sbjct: 317 ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTR 376

Query: 357 LMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW 416
           L +L VP +    C     K+  S  IT+ MFCAGY    +D+C+GDSGGPH T ++ T+
Sbjct: 377 LKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTY 431

Query: 417 YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAP 464
           ++TGIVSWG+GCA  G +G+YT+V+ +++W+ + M++   P     AP
Sbjct: 432 FVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAP 479


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  350 bits (899), Expect = 1e-96
 Identities = 180/442 (40%), Positives = 257/442 (58%), Gaps = 51/442 (11%)

Query: 44  VFVTQEEAHGVLHRRRRANAF-LEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWI 102
           VF+  E A+ +L+R +R N+  LEE   G+LEREC EE+CSFEEARE+F++ ERT  FW 
Sbjct: 30  VFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWK 89

Query: 103 SYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYC 162
            Y DGDQC S+PC NGGSCKD + SY C+C   FEG+NCE      + C  +NG CEQ+C
Sbjct: 90  QYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCEL----DVTCNIKNGRCEQFC 145

Query: 163 SDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQG----------- 211
            +    K  C C EGY L  +  SC P V +PCG++ + +    ++ +            
Sbjct: 146 KNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNST 205

Query: 212 --------------------RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSA 251
                               R+VGG+    G+ PWQV+L       CGG+++N  W+V+A
Sbjct: 206 EAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTA 265

Query: 252 AHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTT--NHDIALLRLH 309
           AHC   ++    +  V GEH++ E +  EQ R V ++I    Y       NHDIALL L 
Sbjct: 266 AHC---VETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELD 322

Query: 310 QPVVLTDHVVPLCLPERTFSERTLAFVRFS--LVSGWGQLLDRGATALELMVLNVPRLMT 367
           +P+VL  +V P+C+ ++   E T  F++F    VSGWG++  +G +AL L  L VP +  
Sbjct: 323 EPLVLNSYVTPICIADK---EYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDR 379

Query: 368 QDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQG 427
             CL+ ++       I   MFCAG+ +G +DSC+GDSGGPH T   GT +LTGI+SWG+ 
Sbjct: 380 ATCLRSTKFT-----IYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEE 434

Query: 428 CATVGHFGVYTRVSQYIEWLQK 449
           CA  G +G+YT+VS+Y+ W+++
Sbjct: 435 CAMKGKYGIYTKVSRYVNWIKE 456


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  311 bits (796), Expect = 1e-84
 Identities = 172/440 (39%), Positives = 250/440 (56%), Gaps = 36/440 (8%)

Query: 44  VFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWIS 103
           VF + E AH VL  R+RAN+FLEELR  SLEREC EE C FEEA+EIF++ + T  FW  
Sbjct: 26  VFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSK 85

Query: 104 YSDGDQCASSP--------CQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNEN 155
           + DGDQC   P        C   G+C D + S+ C C   +EGR C+  +   L C  +N
Sbjct: 86  HVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQ-REVSFLNCSLDN 144

Query: 156 GGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKI-PILEKRNA-------- 206
           GGC  YC +  G +R C C  GY L  D + C P V++PCG+    +EK+ +        
Sbjct: 145 GGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTED 203

Query: 207 --SKPQGRIVGGKVCPKGECPWQVLLLVNGAQL-CGGTLINTIWVVSAAHCFDKIKNWRN 263
              +   R++ GK+  +G+ PWQV+LL +  +L CG  LI+  WV++AAHC D+ K    
Sbjct: 204 QEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK--- 260

Query: 264 LIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCL 323
           L+  LGE+DL   +  E    + +V +   Y   TT++DIALL L QP  L+  +VP+CL
Sbjct: 261 LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICL 320

Query: 324 PERTFSERTLAFV-RFSLVSGWGQLLDRGATALE-----LMVLNVPRLMTQDCLQQSRKV 377
           P+   +ER L    + +LV+GWG    R   A       L  + +P +   +C +    +
Sbjct: 321 PDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNM 380

Query: 378 GDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVY 437
                ++E M CAG     +D+C+GDSGGP    + GTW+L G+VSWG+GC  + ++GVY
Sbjct: 381 -----VSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVY 435

Query: 438 TRVSQYIEWLQKLMRSEPRP 457
           T+VS+Y++W+   +R +  P
Sbjct: 436 TKVSRYLDWIHGHIRDKEAP 455


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  173 bits (438), Expect = 3e-43
 Identities = 96/253 (37%), Positives = 139/253 (54%), Gaps = 16/253 (6%)

Query: 207 SKPQGRIVGGKVCPKGECPWQVLLLVN---GAQLCGGTLINTIWVVSAAHCFDKIKN--- 260
           +K   RIVGG     GE PWQV L V       LCGG+LI   WV++AAHCFD +     
Sbjct: 385 TKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDV 444

Query: 261 WRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVP 320
           WR    +L   D+++   D    ++ ++II   Y     NHDIAL++L  P+  T+   P
Sbjct: 445 WRIYSGILNLSDITK---DTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKP 501

Query: 321 LCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDS 380
           +CLP +     T        V+GWG   ++G     L  +N+P +  ++C ++ +     
Sbjct: 502 ICLPSKG---DTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDY--- 555

Query: 381 PNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRV 440
             IT+ M CAGY +G KD+CKGDSGGP    + G W L GI SWG+GCA     GVYT+V
Sbjct: 556 -KITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKV 614

Query: 441 SQYIEWLQKLMRS 453
           ++Y++W+ +  +S
Sbjct: 615 AEYMDWILEKTQS 627


>gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [Homo
           sapiens]
          Length = 400

 Score =  172 bits (436), Expect = 6e-43
 Identities = 126/412 (30%), Positives = 189/412 (45%), Gaps = 40/412 (9%)

Query: 44  VFVTQEEAHGVLHRRRRANAFL-EELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWI 102
           VF+   +A+ VL R +RA ++L EEL  G+LE+EC EE C +EEARE+F++   T  FW 
Sbjct: 24  VFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWR 83

Query: 103 SYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNE-NGGCEQY 161
            Y  G  C S PC + GSC+D +  Y C C P +EG NCE  K++   C  E   GC+ +
Sbjct: 84  RYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNE---CHPERTDGCQHF 140

Query: 162 CSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPK 221
           C        +C C +GY L  D   C P  +  CG +   EKR                 
Sbjct: 141 CLPGQ-ESYTCSCAQGYRLGEDHKQCVPHDQCACG-VLTSEKRAPDLQ------------ 186

Query: 222 GECPWQVLLL-VNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDE 280
            + PWQV L    G   CGG +I   +V++ A C    +N      +  +   +    D 
Sbjct: 187 -DLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRN------ITVKTYFNRTSQDP 239

Query: 281 QSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSL 340
              ++  V +   Y      +D++LL L  P+      +P+C PE+ F+E  L      L
Sbjct: 240 LMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGL 299

Query: 341 VSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSC 400
           +SGW     R  T L   +   P       L +  + G   N+T  +    Y + S  + 
Sbjct: 300 LSGWA----RNGTDLGNSLTTRP-----VTLVEGEECGQVLNVT--VTTRTYCERSSVAA 348

Query: 401 KGDSGGPHAT-HYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLM 451
                G   T  +RG+W+LTG++   Q      H  + T+VS+Y  W +++M
Sbjct: 349 MHWMDGSVVTREHRGSWFLTGVLG-SQPVGGQAHMVLVTKVSRYSLWFKQIM 399


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  169 bits (429), Expect = 4e-42
 Identities = 98/271 (36%), Positives = 137/271 (50%), Gaps = 19/271 (7%)

Query: 192 EYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSA 251
           E PCG  P          Q RI GG     G+ PWQV +   G  +CGG+L++  WV+SA
Sbjct: 34  EAPCGVAP----------QARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSA 83

Query: 252 AHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQP 311
           AHCF    +       LG H L  +  D +   +  +I   +Y+   +  DIALL+L +P
Sbjct: 84  AHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRP 143

Query: 312 VVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGA--TALELMVLNVPRLM--T 367
           +  + ++ P+CLP    +  +        V+GWG +    +  T   L  L VP +   T
Sbjct: 144 ITFSRYIRPICLPA---ANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRET 200

Query: 368 QDCLQQSRKVGDSPN-ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQ 426
            +CL       + P+ + E M CAGY +G KD+C+GDSGGP +    G WYLTGIVSWG 
Sbjct: 201 CNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGD 260

Query: 427 GCATVGHFGVYTRVSQYIEWLQ-KLMRSEPR 456
            C      GVYT  S Y  W+Q K+   +PR
Sbjct: 261 ACGARNRPGVYTLASSYASWIQSKVTELQPR 291


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  167 bits (424), Expect = 1e-41
 Identities = 110/354 (31%), Positives = 169/354 (47%), Gaps = 26/354 (7%)

Query: 113 SPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSD------HT 166
           S   +G S +    S   FC  +F        ++  ++    +  C++ C++       T
Sbjct: 272 SKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFT 331

Query: 167 GTKRSCRCHEG----YSLLADGVSCTPTVEYPCG------KIPILEKRNASKPQGRIVGG 216
            T     C+EG    Y  L+   S T  +    G      ++  ++    +K + RIVGG
Sbjct: 332 YTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGG 391

Query: 217 KVCPKGECPWQVLLLVNGA---QLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDL 273
               +GE PWQV L         LCGG++I   W+++AAHCF  +++ + L    G  + 
Sbjct: 392 TASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQ 451

Query: 274 SEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTL 333
           SE   D     V ++II   Y    + +DIALL+L   V  TD   P+CLP +   +R +
Sbjct: 452 SEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSK--GDRNV 509

Query: 334 AFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYS 393
            +     V+GWG    R      L    +P +  ++C ++ R       IT  M CAGY 
Sbjct: 510 IYTD-CWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYR----GHKITHKMICAGYR 564

Query: 394 DGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWL 447
           +G KD+CKGDSGGP +  +   W+L GI SWG+GCA     GVYT V +Y++W+
Sbjct: 565 EGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  167 bits (422), Expect = 2e-41
 Identities = 112/347 (32%), Positives = 169/347 (48%), Gaps = 20/347 (5%)

Query: 115 CQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNE----NGGCEQYCSDHT--GT 168
           C     C + L    C C   F+ +   T      +C  +    NG  E+ C +    GT
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGT 533

Query: 169 KRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQV 228
             + +C +   +      C    +   G            P  RIVGG V  +GE PWQ 
Sbjct: 534 F-TFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQA 592

Query: 229 LLLVNGAQLCGGTLINTIWVVSAAHCF--DKIKNWRNLIAVLGEHDLSEHDGDEQSRRVA 286
            L V G  +CGG LI   WV++AAHCF  D + +       LG+   +     E S +V+
Sbjct: 593 SLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVS 652

Query: 287 QVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERT-FSERTLAFVRFSLVSGWG 345
           ++++   +   + ++D+ALL+L  PVV +  V P+CLP R+ F E  L       ++GWG
Sbjct: 653 RLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGL----HCWITGWG 708

Query: 346 QLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSG 405
            L + G  +  L  ++V +L+ QD   +  +      +T  M CAGY  G KD+C+GDSG
Sbjct: 709 ALREGGPISNALQKVDV-QLIPQDLCSEVYRY----QVTPRMLCAGYRKGKKDACQGDSG 763

Query: 406 GPHATH-YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLM 451
           GP       G W+L G+VSWG GC    +FGVYTR++  I W+Q+++
Sbjct: 764 GPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVV 810


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  159 bits (403), Expect = 4e-39
 Identities = 96/280 (34%), Positives = 141/280 (50%), Gaps = 11/280 (3%)

Query: 176  EGYSLLADGVSCTPT--VEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVN 233
            +G+ +L     C     +   C      +K  A     +IVGG    +G  PW V L   
Sbjct: 746  DGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYG 805

Query: 234  GAQLCGGTLINTIWVVSAAHC-FDKIKNWRNLIAVLGEHDLSEHDGDEQ-SRRVAQVIIP 291
            G  LCG +L+++ W+VSAAHC + +        A+LG H  S     +   R + +++I 
Sbjct: 806  GRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVIN 865

Query: 292  STYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRG 351
              Y     ++DIA++ L   V  TD++ P+CLPE     +     R   ++GWG ++ +G
Sbjct: 866  PHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEEN---QVFPPGRNCSIAGWGTVVYQG 922

Query: 352  ATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH 411
             TA  L   +VP L  + C QQ  +     NITE M CAGY +G  DSC+GDSGGP    
Sbjct: 923  TTANILQEADVPLLSNERCQQQMPEY----NITENMICAGYEEGGIDSCQGDSGGPLMCQ 978

Query: 412  YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLM 451
                W+L G+ S+G  CA     GVY RVS++ EW+Q  +
Sbjct: 979  ENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFL 1018


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  159 bits (402), Expect = 5e-39
 Identities = 96/252 (38%), Positives = 131/252 (51%), Gaps = 14/252 (5%)

Query: 207 SKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKN----WR 262
           S  Q RIVGG+    G  PWQV L V    +CGG++I   W+V+AAHC +K  N    W 
Sbjct: 287 SSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWT 346

Query: 263 NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLC 322
               +L +  +    G +    V +VI    Y   T N+DIAL++L +P+   D V P+C
Sbjct: 347 AFAGILRQSFMFYGAGYQ----VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVC 402

Query: 323 LPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPN 382
           LP        L   +   +SGWG   ++G T+  L    V  + TQ C   SR V D+  
Sbjct: 403 LPNPGMM---LQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC--NSRYVYDNL- 456

Query: 383 ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQ 442
           IT  M CAG+  G+ DSC+GDSGGP  T     W+L G  SWG GCA     GVY  V  
Sbjct: 457 ITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 516

Query: 443 YIEWLQKLMRSE 454
           + +W+ + MR++
Sbjct: 517 FTDWIYRQMRAD 528


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  159 bits (402), Expect = 5e-39
 Identities = 96/252 (38%), Positives = 131/252 (51%), Gaps = 14/252 (5%)

Query: 207 SKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKN----WR 262
           S  Q RIVGG+    G  PWQV L V    +CGG++I   W+V+AAHC +K  N    W 
Sbjct: 250 SSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWT 309

Query: 263 NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLC 322
               +L +  +    G +    V +VI    Y   T N+DIAL++L +P+   D V P+C
Sbjct: 310 AFAGILRQSFMFYGAGYQ----VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVC 365

Query: 323 LPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPN 382
           LP        L   +   +SGWG   ++G T+  L    V  + TQ C   SR V D+  
Sbjct: 366 LPNPGMM---LQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC--NSRYVYDNL- 419

Query: 383 ITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQ 442
           IT  M CAG+  G+ DSC+GDSGGP  T     W+L G  SWG GCA     GVY  V  
Sbjct: 420 ITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMV 479

Query: 443 YIEWLQKLMRSE 454
           + +W+ + MR++
Sbjct: 480 FTDWIYRQMRAD 491


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  158 bits (400), Expect = 9e-39
 Identities = 95/264 (35%), Positives = 139/264 (52%), Gaps = 15/264 (5%)

Query: 195 CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHC 254
           CG  P +EK        R+VGG     GE PWQV L       CG T++   W++SAAHC
Sbjct: 492 CGARPAMEKPT------RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC 545

Query: 255 FDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVL 314
           F+  K    + A LG   L    G      + +V++   Y PG  + D+A+L L  P+  
Sbjct: 546 FNHTKV-EQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAF 604

Query: 315 TDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQS 374
             ++ P+CLP    + +     R  ++SGWG   +  AT  EL+      ++ Q    ++
Sbjct: 605 NKYIQPVCLP---LAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQ----KT 657

Query: 375 RKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYR-GTWYLTGIVSWGQGCATVGH 433
             V  + ++T+ M CAG+ +G  DSC+GDSGGP A     G +YL GIVSWG GCA V  
Sbjct: 658 CSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKK 717

Query: 434 FGVYTRVSQYIEWLQKLMRSEPRP 457
            GVYTR+++   W+ ++M S+P P
Sbjct: 718 PGVYTRITRLKGWILEIMSSQPLP 741



 Score =  155 bits (391), Expect = 1e-37
 Identities = 93/257 (36%), Positives = 128/257 (49%), Gaps = 8/257 (3%)

Query: 211 GRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGE 270
           GRIVGG     GE PWQ  L  N    CG  +IN  W+VSAAHCF++ ++    +A +G 
Sbjct: 201 GRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGA 260

Query: 271 HDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSE 330
             LS  +      +V Q++    Y   T + D+A+L L  P+    H+ P+CLP  T   
Sbjct: 261 TYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAAT--- 317

Query: 331 RTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 390
                 +  L+SGWG L +      E++      L+ Q     +   G S  +T+ M CA
Sbjct: 318 HIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHS--LTDRMVCA 373

Query: 391 GYSDGSKDSCKGDSGGPHATHY-RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 449
           GY DG  DSC+GDSGGP       G ++L GIVSWG GCA     GVY RV++  +W+ +
Sbjct: 374 GYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILE 433

Query: 450 LMRSEPRPGVLLRAPFP 466
                  P     AP P
Sbjct: 434 ATTKASMPLAPTMAPAP 450



 Score =  140 bits (352), Expect = 3e-33
 Identities = 92/238 (38%), Positives = 123/238 (51%), Gaps = 12/238 (5%)

Query: 212  RIVGGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGE 270
            RIVGG    +GE PWQV L +   +  CG  L+   W++SAAHCFD   + +   A LG 
Sbjct: 826  RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885

Query: 271  HDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSE 330
              LS  +G  Q  RVA++     Y   T ++D+ALL L  PV  +  V P+CLPE   + 
Sbjct: 886  PFLSGAEG--QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEP--AP 941

Query: 331  RTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 390
            R     R  +++GWG + + G+ A +L    V  L  Q C +          I+  M CA
Sbjct: 942  RPPDGTR-CVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFY-----PVQISSRMLCA 995

Query: 391  GYSDGSKDSCKGDSGGPHATHY-RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWL 447
            G+  G  DSC GD+GGP A     G W LTG+ SWG GC      GVYTRV+    W+
Sbjct: 996  GFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053


>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  154 bits (388), Expect = 2e-37
 Identities = 93/238 (39%), Positives = 128/238 (53%), Gaps = 21/238 (8%)

Query: 212 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 271
           +IVGG +C +   P+QV L  +G   CGG+LI+  WVVSA HC+      R     LGEH
Sbjct: 23  KIVGGYICEENSVPYQVSLN-SGYHFCGGSLISEQWVVSAGHCYKSRIQVR-----LGEH 76

Query: 272 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 331
           ++   +G+EQ    A++I    Y   T ++DI L++L  P V+   V  + LP    +  
Sbjct: 77  NIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAG 136

Query: 332 TLAFVRFSLVSGWGQLLDRGATAL-ELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 390
           T      SL+SGWG  L  GA    EL  L+ P L   +C     +      IT  MFC 
Sbjct: 137 TE-----SLISGWGNTLSSGADYPDELQCLDAPVLSQAEC-----EASYPGKITNNMFCV 186

Query: 391 GYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ 448
           G+ +G KDSC+GDSGGP  ++      L GIVSWG GCA     GVYT+V  Y++W++
Sbjct: 187 GFLEGGKDSCQGDSGGPVVSNGE----LQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK 240


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  152 bits (384), Expect = 6e-37
 Identities = 90/252 (35%), Positives = 130/252 (51%), Gaps = 18/252 (7%)

Query: 211 GRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCF-----DKIKNWRNLI 265
           GRIVGG +    + PWQV L      +CGGTLI+  WV++AAHCF       ++ W+   
Sbjct: 324 GRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYA 383

Query: 266 AVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPE 325
                H L E      +  +A++II S Y     ++DIAL+RL +P+ L+ H+ P CLP 
Sbjct: 384 GTSNLHQLPE------AASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLP- 436

Query: 326 RTFSERTLAFVRFSLVSGWGQLLDRG-ATALELMVLNVPRLMTQDCLQQSRKVGDSPNIT 384
                +T +      ++G+G+  +    T+  L  + V  +  + C      V DS  +T
Sbjct: 437 --MHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC--NDYLVYDS-YLT 491

Query: 385 EYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYI 444
             M CAG   G +DSC+GDSGGP        WYL G+ SWG GC      GVYT+V++ +
Sbjct: 492 PRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVL 551

Query: 445 EWLQKLMRSEPR 456
            W+   M SE R
Sbjct: 552 PWIYSKMESEVR 563


>gi|4504383 HGF activator preproprotein [Homo sapiens]
          Length = 655

 Score =  152 bits (383), Expect = 8e-37
 Identities = 130/469 (27%), Positives = 188/469 (40%), Gaps = 100/469 (21%)

Query: 75  RECKEEQCSFEEAREIFKDA------------ERTKLF----WISYSDGDQCASSPCQNG 118
           ++C  E+C F+E R  + +             E+ + F    W   +    C SSPC NG
Sbjct: 195 KDCGTEKC-FDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNG 253

Query: 119 GSCKDQLQS--YICFCLPAFEGRNCETHKDDQLICVNENG-------------------- 156
           G+C   + +   +C C P F GR C    D++    N  G                    
Sbjct: 254 GTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSD 313

Query: 157 -------------------GCEQYCSDHTGTKR-------------------SCRCHEGY 178
                              G   YC +    +R                   +C      
Sbjct: 314 LLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRV 373

Query: 179 SLLADGVSCTPTVEYP----CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNG 234
            L  D ++  P    P    CG+    +KR   +P  RI+GG     G  PW   + + G
Sbjct: 374 QLSPDLLATLPEPASPGRQACGRRH--KKRTFLRP--RIIGGSSSLPGSHPWLAAIYI-G 428

Query: 235 AQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTY 294
              C G+L++T WVVSAAHCF       ++  VLG+H  +      Q+  + + I  + Y
Sbjct: 429 DSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLY 488

Query: 295 -VPGTTNHDIALLRLHQP----VVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLD 349
            V   ++HD+ L+RL +        +  V P+CLPE      T        ++GWG L +
Sbjct: 489 SVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPE---PGSTFPAGHKCQIAGWGHLDE 545

Query: 350 R-GATALELMVLNVPRLMTQDCLQQSRKVGD-SPNITEYMFCAGYSDGSKDSCKGDSGGP 407
                +  L    VP +    C        D SPN    M CAGY D   D+C+GDSGGP
Sbjct: 546 NVSGYSSSLREALVPLVADHKCSSPEVYGADISPN----MLCAGYFDCKSDACQGDSGGP 601

Query: 408 HATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPR 456
            A    G  YL GI+SWG GC  +   GVYTRV+ Y++W+   +R   R
Sbjct: 602 LACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRR 650



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 33/95 (34%), Positives = 43/95 (45%), Gaps = 13/95 (13%)

Query: 108 DQCASSPCQNGGSCKD--QLQSYICFCLPAFEGRNCETHKDDQLICVNEN-----GGCEQ 160
           D CAS PC NGGSC +    QSY C C  AF G++C T K     C +E       G ++
Sbjct: 162 DPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEK-----CFDETRYEYLEGGDR 216

Query: 161 YCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPC 195
           +     G    C C  G +   +G   T  +  PC
Sbjct: 217 WARVRQGHVEQCECFGGRT-WCEGTRHTACLSSPC 250


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  149 bits (376), Expect = 5e-36
 Identities = 92/238 (38%), Positives = 127/238 (53%), Gaps = 21/238 (8%)

Query: 212 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 271
           +IVGG  C +   P+QV L  +G+  CGG+LI+  WVVSAAHC+      R     LGEH
Sbjct: 80  KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKTRIQVR-----LGEH 133

Query: 272 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 331
           ++   +G+EQ    A++I    Y   T ++DI L++L  P V+   V  + LP    +  
Sbjct: 134 NIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAG 193

Query: 332 TLAFVRFSLVSGWGQLLDRGATAL-ELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 390
           T       L+SGWG  L  GA    EL  L+ P L   +C     K      IT  MFC 
Sbjct: 194 TEC-----LISGWGNTLSFGADYPDELKCLDAPVLTQAEC-----KASYPGKITNSMFCV 243

Query: 391 GYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ 448
           G+ +G KDSC+ DSGGP   + +    L G+VSWG GCA     GVYT+V  Y++W++
Sbjct: 244 GFLEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIK 297


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  149 bits (376), Expect = 5e-36
 Identities = 92/238 (38%), Positives = 127/238 (53%), Gaps = 21/238 (8%)

Query: 212 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 271
           +IVGG  C +   P+QV L  +G+  CGG+LI+  WVVSAAHC+      R     LGEH
Sbjct: 23  KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKTRIQVR-----LGEH 76

Query: 272 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 331
           ++   +G+EQ    A++I    Y   T ++DI L++L  P V+   V  + LP    +  
Sbjct: 77  NIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAG 136

Query: 332 TLAFVRFSLVSGWGQLLDRGATAL-ELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCA 390
           T       L+SGWG  L  GA    EL  L+ P L   +C     K      IT  MFC 
Sbjct: 137 TEC-----LISGWGNTLSFGADYPDELKCLDAPVLTQAEC-----KASYPGKITNSMFCV 186

Query: 391 GYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ 448
           G+ +G KDSC+ DSGGP   + +    L G+VSWG GCA     GVYT+V  Y++W++
Sbjct: 187 GFLEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIK 240


>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
          Length = 352

 Score =  149 bits (376), Expect = 5e-36
 Identities = 95/274 (34%), Positives = 139/274 (50%), Gaps = 20/274 (7%)

Query: 189 PTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWV 248
           P+    CG   I E R       RI GG     GE PWQV +       CGG+++N  W+
Sbjct: 47  PSPVSECGDRSIFEGRTR---YSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWI 103

Query: 249 VSAAHCFDKIKNW-RNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLR 307
           ++AAHC    + +   L  VLG +DL+      + + VA +I+   +     ++DIALL 
Sbjct: 104 LTAAHCLYSEELFPEELSVVLGTNDLT--SPSMEIKEVASIILHKDFKRANMDNDIALLL 161

Query: 308 LHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQ--LLDRGATALELMVLNVPRL 365
           L  P+ L D  VP+CLP    ++   A  R   V+GWGQ    D+ +   +LM   +  +
Sbjct: 162 LASPIKLDDLKVPICLP----TQPGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIM 217

Query: 366 MTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGP-HATHYRG-TWYLTGIVS 423
             ++C +        P +T+ M CAGY + S D+CKGDSGGP   T   G  WY  GI+S
Sbjct: 218 DWEECSKM------FPKLTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIIS 271

Query: 424 WGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRP 457
           WG+ C      G+YT +  Y  W++K+ + E RP
Sbjct: 272 WGKSCGEKNTPGIYTSLVNYNLWIEKVTQLEGRP 305


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  149 bits (375), Expect = 7e-36
 Identities = 92/264 (34%), Positives = 132/264 (50%), Gaps = 22/264 (8%)

Query: 193 YPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVN-GAQLCGGTLINTIWVVSA 251
           + CGK  +  K    K  GR+VGG V      PWQV L    G   CGGTLI+  WV++A
Sbjct: 565 FDCGKPQVEPK----KCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTA 620

Query: 252 AHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQP 311
           AHC +K     +   +LG H     +   Q   V+++ +  T        DIALL+L  P
Sbjct: 621 AHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPT------RKDIALLKLSSP 674

Query: 312 VVLTDHVVPLCLPERTF--SERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD 369
            V+TD V+P CLP   +  ++RT  F+     +GWG+        L L    +P +  + 
Sbjct: 675 AVITDKVIPACLPSPNYVVADRTECFI-----TGWGETQGTFGAGL-LKEAQLPVIENKV 728

Query: 370 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCA 429
           C +     G    +     CAG+  G  DSC+GDSGGP     +  + L G+ SWG GCA
Sbjct: 729 CNRYEFLNG---RVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCA 785

Query: 430 TVGHFGVYTRVSQYIEWLQKLMRS 453
                GVY RVS+++ W++ +MR+
Sbjct: 786 RPNKPGVYVRVSRFVTWIEGVMRN 809


>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
          Length = 622

 Score =  149 bits (375), Expect = 7e-36
 Identities = 99/291 (34%), Positives = 153/291 (52%), Gaps = 37/291 (12%)

Query: 192 EYPCGKIPILEKRNA----------SKPQGRIVGGKVCPKGECPWQVLLLVNGAQ--LCG 239
           E  CG  P+ EK++           S   GRIV G     G  PWQV+L     Q  LCG
Sbjct: 333 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG 392

Query: 240 GTLINTIWVVSAAHC-----FDKIKNWRNLIAVLGEHDLSEHDGD-EQSRRVAQVIIPST 293
            +LI+  WV++AAHC     +DK     +L+  +G+H  + ++ + E+   + ++ I   
Sbjct: 393 ASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPR 452

Query: 294 YV-PGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLD--- 349
           Y      + DIAL++L +PV  +D++ P+CLP+R  +   L       V+GWG L +   
Sbjct: 453 YNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWT 512

Query: 350 ----RGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYS--DGSK-DSCKG 402
               +G  ++ L V+N+P +    C   +R       IT+ MFCAGY   +G + D+C+G
Sbjct: 513 ANVGKGQPSV-LQVVNLPIVERPVCKDSTRI-----RITDNMFCAGYKPDEGKRGDACEG 566

Query: 403 DSGGPHA--THYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLM 451
           DSGGP    + +   WY  GIVSWG+GC   G +G YT V +  +W+QK++
Sbjct: 567 DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI 617



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 38/93 (40%), Positives = 51/93 (54%), Gaps = 11/93 (11%)

Query: 13  LGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGS 72
           L L GCLA   +      +            VF+  ++A  +L R RRAN FLEE+R G+
Sbjct: 7   LQLPGCLALAALCSLVHSQ-----------HVFLAPQQARSLLQRVRRANTFLEEVRKGN 55

Query: 73  LERECKEEQCSFEEAREIFKDAERTKLFWISYS 105
           LEREC EE CS+EEA E  + +  T +FW  Y+
Sbjct: 56  LERECVEETCSYEEAFEALESSTATDVFWAKYT 88


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  148 bits (374), Expect = 9e-36
 Identities = 91/259 (35%), Positives = 132/259 (50%), Gaps = 17/259 (6%)

Query: 190 TVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVV 249
           TV+  CGK  +    N      RI  G + PK   PWQ  L  +    CG TLI+  W+V
Sbjct: 170 TVQASCGKRVVPLNVN------RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLV 223

Query: 250 SAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLH 309
           +AAHCF K KN        G    ++ +     R V + II   Y      +DIA++++ 
Sbjct: 224 TAAHCFQKYKNPHQWTVSFG----TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS 279

Query: 310 QPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD 369
             V  +D +  +CLPE + S +    V    ++G+G L   G +  +L    V ++++ D
Sbjct: 280 SRVTFSDDIRQICLPEASASFQPNLTVH---ITGFGALYYGGESQNDLREARV-KIISDD 335

Query: 370 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH-YRGTWYLTGIVSWGQGC 428
             +Q +  G+  +I   MFCAGY +G  D+C+GDSGGP  T   + TWYL GIVSWG  C
Sbjct: 336 VCKQPQVYGN--DIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 393

Query: 429 ATVGHFGVYTRVSQYIEWL 447
                 GVYT+V+ Y  W+
Sbjct: 394 GQKDKPGVYTQVTYYRNWI 412


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  148 bits (374), Expect = 9e-36
 Identities = 91/259 (35%), Positives = 132/259 (50%), Gaps = 17/259 (6%)

Query: 190 TVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVV 249
           TV+  CGK  +    N      RI  G + PK   PWQ  L  +    CG TLI+  W+V
Sbjct: 173 TVQASCGKRVVPLNVN------RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLV 226

Query: 250 SAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLH 309
           +AAHCF K KN        G    ++ +     R V + II   Y      +DIA++++ 
Sbjct: 227 TAAHCFQKYKNPHQWTVSFG----TKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS 282

Query: 310 QPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD 369
             V  +D +  +CLPE + S +    V    ++G+G L   G +  +L    V ++++ D
Sbjct: 283 SRVTFSDDIRQICLPEASASFQPNLTVH---ITGFGALYYGGESQNDLREARV-KIISDD 338

Query: 370 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH-YRGTWYLTGIVSWGQGC 428
             +Q +  G+  +I   MFCAGY +G  D+C+GDSGGP  T   + TWYL GIVSWG  C
Sbjct: 339 VCKQPQVYGN--DIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 396

Query: 429 ATVGHFGVYTRVSQYIEWL 447
                 GVYT+V+ Y  W+
Sbjct: 397 GQKDKPGVYTQVTYYRNWI 415


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  148 bits (373), Expect = 1e-35
 Identities = 86/246 (34%), Positives = 125/246 (50%), Gaps = 9/246 (3%)

Query: 212 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 271
           R+VGG+   +GE PWQV +  NG+  CGG+LI   WV++AAHCF           +LG  
Sbjct: 34  RMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLLGAR 93

Query: 272 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 331
            L +        RV QV     Y    ++ D+AL+ L  PV  T++++P+CLP+ +    
Sbjct: 94  QLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSVIFE 153

Query: 332 TLAFVRFSLVSGWGQLLDRGATALE--LMVLNVPRLMTQDC---LQQSRKVGDSP-NITE 385
           T        V+GWG   +         L  L VP + T  C     +  + G  P  I  
Sbjct: 154 T---GMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKN 210

Query: 386 YMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIE 445
            M CAG+ +G KD+CKGDSGGP       +W   G++SWG+GCA     GVY RV+ +  
Sbjct: 211 DMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHN 270

Query: 446 WLQKLM 451
           W+ +++
Sbjct: 271 WIHRII 276


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  147 bits (371), Expect = 2e-35
 Identities = 99/269 (36%), Positives = 134/269 (49%), Gaps = 16/269 (5%)

Query: 208 KPQ--GRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLI 265
           KPQ   R+VGG+     E PW V +  NG   C G+L+ + WV++AAHCF    N   L 
Sbjct: 43  KPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLF 102

Query: 266 AVL-GEHDLSEHDGDEQSRRVAQVIIPSTYV-PGTTNHDIALLRLHQPVVLTDHVVPLCL 323
           +VL G   L       Q   VA V     Y        DIAL+RL + +  ++ V+P+CL
Sbjct: 103 SVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICL 162

Query: 324 PERTFSERTLAFVRFSLVSGWGQLLDRGATA--LELMVLNVPRLMTQDCLQQS-RKVGDS 380
           P+ +     L       +SGWG + D         L  L VP + ++ C     R  G  
Sbjct: 163 PDASIH---LPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQG 219

Query: 381 PNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRV 440
           P ITE M CAGY +G +D+C GDSGGP      G W L GI+SWG+GCA     GVY  +
Sbjct: 220 P-ITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISL 278

Query: 441 SQYIEWLQKL-----MRSEPRPGVLLRAP 464
           S +  W++K+     +R   + G  LRAP
Sbjct: 279 SAHRSWVEKIVQGVQLRGRAQGGGALRAP 307


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  147 bits (370), Expect = 3e-35
 Identities = 88/239 (36%), Positives = 123/239 (51%), Gaps = 11/239 (4%)

Query: 212 RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEH 271
           RI+GG    +G  PWQV L +N A  CGG+LIN +W+++AAHCF    N R+ IA  G  
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSG-- 243

Query: 272 DLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSER 331
                   +   RV  ++I + Y   T  +DIAL+RL   V  T  +  +CLP  T   +
Sbjct: 244 --ISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAAT---Q 298

Query: 332 TLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAG 391
            +     + V+GWG     G T  EL    V R+++ D          +  I   M CAG
Sbjct: 299 NIPPGSTAYVTGWGAQEYAGHTVPELRQGQV-RIISNDVCNAPHSYNGA--ILSGMLCAG 355

Query: 392 YSDGSKDSCKGDSGGPHATH-YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 449
              G  D+C+GDSGGP      R  W++ GIVSWG  C      GVYTRV+ Y++W+++
Sbjct: 356 VPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQ 414


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  146 bits (369), Expect = 3e-35
 Identities = 94/262 (35%), Positives = 134/262 (51%), Gaps = 31/262 (11%)

Query: 209 PQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDK----IKNWR-- 262
           P  RIVGG+    G  PWQV L  +GA LCGG+L++  WV++AAHCF +    +  WR  
Sbjct: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVF 218

Query: 263 -NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVP------GTTNHDIALLRLHQPVVLT 315
              +A    H L           V  V+    Y+P         ++DIAL+ L  P+ LT
Sbjct: 219 AGAVAQASPHGL--------QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270

Query: 316 DHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSR 375
           +++ P+CLP    + + L   +   V+GWG     G  A  L    VP +++ D    + 
Sbjct: 271 EYIQPVCLPA---AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVP-IISNDVCNGAD 326

Query: 376 KVGDSPNITEYMFCAGYSDGSKDSCKGDSGGP----HATHYRGTWYLTGIVSWGQGCATV 431
             G+   I   MFCAGY +G  D+C+GDSGGP     +      W L GIVSWG GCA  
Sbjct: 327 FYGN--QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALA 384

Query: 432 GHFGVYTRVSQYIEWLQKLMRS 453
              GVYT+VS + EW+ + +++
Sbjct: 385 QKPGVYTKVSDFREWIFQAIKT 406


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  146 bits (369), Expect = 3e-35
 Identities = 94/262 (35%), Positives = 134/262 (51%), Gaps = 31/262 (11%)

Query: 209 PQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDK----IKNWR-- 262
           P  RIVGG+    G  PWQV L  +GA LCGG+L++  WV++AAHCF +    +  WR  
Sbjct: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVF 218

Query: 263 -NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVP------GTTNHDIALLRLHQPVVLT 315
              +A    H L           V  V+    Y+P         ++DIAL+ L  P+ LT
Sbjct: 219 AGAVAQASPHGL--------QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270

Query: 316 DHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSR 375
           +++ P+CLP    + + L   +   V+GWG     G  A  L    VP +++ D    + 
Sbjct: 271 EYIQPVCLPA---AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVP-IISNDVCNGAD 326

Query: 376 KVGDSPNITEYMFCAGYSDGSKDSCKGDSGGP----HATHYRGTWYLTGIVSWGQGCATV 431
             G+   I   MFCAGY +G  D+C+GDSGGP     +      W L GIVSWG GCA  
Sbjct: 327 FYGN--QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALA 384

Query: 432 GHFGVYTRVSQYIEWLQKLMRS 453
              GVYT+VS + EW+ + +++
Sbjct: 385 QKPGVYTKVSDFREWIFQAIKT 406


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  146 bits (369), Expect = 3e-35
 Identities = 102/288 (35%), Positives = 137/288 (47%), Gaps = 35/288 (12%)

Query: 188 TPTVEYP----CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLI 243
           +PT E P    CG+          +P  RIVGG     G  PWQV L   G  +CGG+LI
Sbjct: 27  SPTQEEPEDLDCGR---------PEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLI 77

Query: 244 NTIWVVSAAHCF------DKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPG 297
              WV+SAAHCF      +    W  L   LG H          +R VA +++P+ Y   
Sbjct: 78  APSWVLSAAHCFMTNGTLEPAAEWSVL---LGVHSQDGPLDGAHTRAVAAIVVPANYSQV 134

Query: 298 TTNHDIALLRLHQPVVLTDHVVPLCLPERT--FSERTLAFVRFSLVSGWGQLLDRGATAL 355
               D+ALLRL  P  L   V P+CLP  +  F   T  +      +GWG + +     L
Sbjct: 135 ELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWA-----TGWGDVQEADPLPL 189

Query: 356 ELMVLNVP-RLM---TQDCL-QQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHAT 410
             ++  V  RL+   T  CL  Q      +  I   M CAGY +G +D+C+GDSGGP   
Sbjct: 190 PWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVC 249

Query: 411 HYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWL-QKLMRSEPRP 457
              G W+  GI S+G GC      GV+T V+ Y  W+ +++M SEP P
Sbjct: 250 EEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGSEPGP 297



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 63/232 (27%), Positives = 92/232 (39%), Gaps = 42/232 (18%)

Query: 216 GKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCF----------DKIKNWRNLI 265
           GK    G  PW+  ++V G++ C G L++  WV++ A CF            +  WR L+
Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385

Query: 266 AVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPE 325
                          ++ RVA+ ++           D+ALL+L  PV L+    P+CLP 
Sbjct: 386 -----------PSRPRAERVAR-LVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPH 433

Query: 326 RTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQ---DCL--QQSRKV--- 377
               E          ++ WG    RG  AL    L    L+      CL  +Q   V   
Sbjct: 434 ---PEHYFLPGSRCRLARWG----RGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLP 486

Query: 378 GDSPNITEYMFCAGYSDGSK-DSCKGDSGGPHATHYRGTWYLTGIVSWGQGC 428
           GD P    +  C  Y +  +  SC  DS         GTW+L GI  +  GC
Sbjct: 487 GDPP----HALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC 534



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 54/205 (26%), Positives = 82/205 (40%), Gaps = 22/205 (10%)

Query: 225 PWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR--NLIAVLGEHDLSE-HDGDEQ 281
           PW   + V G ++C G L+   WV++A HC  +  +     +   LG    S    G + 
Sbjct: 602 PWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQV 661

Query: 282 SRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLV 341
           SR V  + +P           +ALL L   V  +   +P+CL           +     V
Sbjct: 662 SRLVISIRLPQHL---GLRPPLALLELSSRVEPSPSALPICLHPAGIPPGASCW-----V 713

Query: 342 SGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCK 401
            GW +  DR   A  + +L   R+   DCL Q    G  P  T    C  Y++G ++ C+
Sbjct: 714 LGWKEPQDRVPVAAAVSIL-TQRIC--DCLYQ----GILPPGT---LCVLYAEGQENRCE 763

Query: 402 GDSGGPHATHY-RGTWYLTGIVSWG 425
             S  P       G+W L G+   G
Sbjct: 764 MTSAPPLLCQMTEGSWILVGMAVQG 788


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.448 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,670,301
Number of Sequences: 37866
Number of extensions: 1016588
Number of successful extensions: 4156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 2241
Number of HSP's gapped (non-prelim): 1270
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.